U.S. patent application number 11/181409 was filed with the patent office on 2007-01-18 for cyclosporin compositions.
This patent application is currently assigned to Allergan, Inc.. Invention is credited to James N. Chang, Bruce A. Firestone, Orest Olejnik.
Application Number | 20070015691 11/181409 |
Document ID | / |
Family ID | 37662335 |
Filed Date | 2007-01-18 |
United States Patent
Application |
20070015691 |
Kind Code |
A1 |
Chang; James N. ; et
al. |
January 18, 2007 |
Cyclosporin compositions
Abstract
A composition is disclosed herein comprising from about 0.001%
to about 0.4% cyclosporin A, castor oil, and a surfactant selected
from the group consisting of alcohol ethoxylates, alcohols, alkyl
glycosides, alkyl polyglycosides, alkylphenol ethoxylates, amine
oxides, block polymers, carboxylated alcohol or alkylphenol
ethoxylates, carboxylic acids/fatty acids, cellulose derivatives,
ethoxylated alcohols, ethoxylated alkylphenols, ethoxylated aryl
phenols, ethoxylated fatty acids, ethoxylated fatty acids,
ethoxylated fatty esters and oils, fatty alcohols, fatty esters,
glycol esters, lanolin-based derivatives, lecithin and lecithin
derivatives, lignin and lignin derivatives, methyl esters,
monoglycerides and derivatives , phosphalipids, polyacrylic acids,
polyethylene glycols, polyethylene oxide-polypropylene oxide
copolymers, polyethylene oxides, polymeric surfactants,
polypropylene oxides, propoxylated alcohols, propoxylated alkyl
phenols, propoxylated fatty acids, protein-based surfactants,
sarcosine derivatives, silicone-based surfactants, sorbitan
derivatives, stearates, sucrose and glucose esters and derivatives,
and combinations thereof.
Inventors: |
Chang; James N.; (Newport
Beach, CA) ; Olejnik; Orest; (Coto De Caza, CA)
; Firestone; Bruce A.; (Irvine, CA) |
Correspondence
Address: |
ALLERGAN, INC.
2525 DUPONT DRIVE, T2-7H
IRVINE
CA
92612-1599
US
|
Assignee: |
Allergan, Inc.
|
Family ID: |
37662335 |
Appl. No.: |
11/181409 |
Filed: |
July 13, 2005 |
Current U.S.
Class: |
514/20.5 ;
424/731 |
Current CPC
Class: |
A61K 47/34 20130101;
A61K 47/32 20130101; A61K 9/107 20130101; A61K 47/44 20130101; A61P
27/02 20180101; A61K 9/0048 20130101; A61K 47/38 20130101; A61K
38/13 20130101 |
Class at
Publication: |
514/011 ;
424/731 |
International
Class: |
A61K 38/13 20070101
A61K038/13; A61K 36/47 20060101 A61K036/47 |
Claims
1. A composition comprising from about 0.001% to about 0.4%
cyclosporin A, castor oil, and a surfactant selected from the group
consisting of alcohol ethoxylates, alcohols, alkyl glycosides,
alkyl polyglycosides, alkylphenol ethoxylates, amine oxides, block
polymers, carboxylated alcohol or alkylphenol ethoxylates,
carboxylic acids/fatty acids, cellulose derivatives, ethoxylated
alcohols, ethoxylated alkylphenols, ethoxylated aryl phenols,
ethoxylated fatty acids, ethoxylated fatty acids, ethoxylated fatty
esters and oils, fatty alcohols, fatty esters, glycol esters,
lanolin-based derivatives, lecithin and lecithin derivatives,
lignin and lignin derivatives, methyl esters, monoglycerides and
derivatives, phosphalipids, polyacrylic acids, polyethylene
glycols, polyethylene oxide-polypropylene oxide copolymers,
polyethylene oxides, polymeric surfactants, polypropylene oxides,
propoxylated alcohols, propoxylated alkyl phenols, propoxylated
fatty acids, protein-based surfactants, sarcosine derivatives,
silicone-based surfactants, stearates, sucrose and glucose esters
and derivatives, and combinations thereof, wherein the surfactant
is not a sorbitan derivative wherein said composition is an
ophthalmically acceptable emulsion.
2. The composition of claim 1 comprising from about 0.005% to about
0.05% cyclosporin A.
3. The composition of claim 2 comprising about 0.05% cyclosporin
A.
4. (Canceled)
5. The composition of claim 2 comprising from about 0.005% to about
0.05% cyclosporin A, castor oil, and a stearate.
6. The composition of claim 2 comprising from about 0.005% to about
0.05% cyclosporin A, castor oil, and glyceryl stearate.
7. The composition of claim 2 comprising from about 0.005% to about
0.05% cyclosporin A, castor oil, and isopropyl stearate.
8. The composition of claim 2 comprising from about 0.005% to about
0.05% cyclosporin A, castor oil, and polyethylene glycol.
9. The composition of claim 2 comprising from about 0.005% to about
0.05% cyclosporin A, castor oil, and polyethylene oxide.
10. The composition of claim 2 comprising from about 0.005% to
about 0.05% cyclosporin A, castor oil, and a polyethylene
oxide-polypropylene oxide copolymer.
11. The composition of claim 2 comprising from about 0.005% to
about 0.05% cyclosporin A, castor oil, and an alcohol
ethoxylate.
12. The composition of claim 2 comprising from about 0.005% to
about 0.05% cyclosporin A, castor oil, and an alkylphenol
ethoxylate.
13. The composition of claim 2 comprising from about 0.005% to
about 0.05% cyclosporin A, castor oil, and an alkyl glycoside.
14. The composition of claim 2 comprising from about 0.005% to
about 0.05% cyclosporin A, castor oil, and alkyl polyglycoside.
15. The composition of claim 2 comprising from about 0.005% to
about 0.05% cyclosporin A, castor oil, and a fatty alcohol.
16. The composition of claim 2 comprising from about 0.005% to
about 0.05% cyclosporin A, castor oil, and hydroxypropylmethyl
cellulose.
17. The composition of claim 2 comprising from about 0.005% to
about 0.05% cyclosporin A, castor oil, and carboxymethyl
cellulose.
18. The composition of claim 2 comprising from about 0.005% to
about 0.05% cyclosporin A, castor oil, and a polyacrylic acid.
19. The composition of claim 2 comprising from about 0.005% to
about 0.05% cyclosporin A, castor oil, and a Carbomer.
20. The composition of claim 2 comprising from about 0.005% to
about 0.05% cyclosporin A, castor oil, and a phosphalipid.
21. A composition comprising from about 0.001% to about 0.4%
cyclosporin A, castor oil, and an ethoxylated fatty acid
surfactant, wherein said composition is an ophthalmically
acceptable emulsion.
22. The composition of claim 34 comprising from about 0.005% to
about 0.05% cyclosporin A.
23. The composition of claim 22 comprising about 0.05% cyclosporin
A.
24. The composition of claim 22 wherein the ethoxylated fatty acid
surfactant is Aldo PGHMS.RTM..
25. The composition of claim 22 wherein the ethoxylated fatty acid
surfactant is Alkamuls TO-15/HR.RTM..
26. The composition of claim 22 wherein the ethoxylated fatty acid
surfactant is Armotan AL-69-66.RTM..
27. The composition of claim 22 wherein the ethoxylated fatty acid
surfactant is Cerasynt 840.RTM., Cerasynt 945.RTM., or a
combination thereof.
28. The composition of claim 22 wherein the ethoxylated fatty acid
surfactant is Crystal Inhibitor No. 5.RTM..
29. The composition of claim 22 wherein the ethoxylated fatty acid
surfactant is DeThox Acid L-9.RTM., DeThox Acid S-8.RTM., or a
combination thereof.
30. The composition of claim 22 wherein the ethoxylated fatty acid
surfactant is Ethofat 242/25.RTM..
31. The composition of claim 22 wherein the ethoxylated fatty acid
surfactant is Hydropalat 65.RTM..
32. The composition of claim 22 wherein the ethoxylated fatty acid
surfactant is selected from Lipo EGMS.RTM., Lipopeg 2 DL.RTM.,
Lipopeg 4 DL.RTM., Lipopeg 4-L.RTM., Lipopeg 39-S.RTM., Lipopeg
4-S.RTM., Lipopeg 10-S.RTM., Lipopeg 100-S.RTM., Lipopeg 6000
DS.RTM., and combinations thereof.
33. The composition of claim 22 wherein the ethoxylated fatty acid
surfactant is selected from Lumulse 40-L.RTM., Lumulse 40-S.RTM.,
Lumulse 42-L.RTM., Lumulse 42-S.RTM., Lumulse 100-S.RTM.,Lumulse
602-S.RTM., and combinations thereof.
34. A composition comprising from about 0.001% to about 0.4%
cyclosporin A, castor oil, and an ethoxylated fatty acid
surfactant, wherein said composition is an ophthalmically
acceptable emulsion, and PEG 200 monolaurate, PEG 200 dilaurate,
PEG 400 monolaurate, PEG 400 dilaurate, PEG 600 mololaurate, PEG
600 dilaurate, PEG 200 monooleate, PEG 200 dioleate, PEG 400
monooleate, PEG 400 dioleate, PEG 600 monooleate, PEG 600 dioleate,
PEG 200 monotallate, PEG 200 ditallate, PEG 400 monotallate, PEG
400 ditallate, PEG 600 monotallate, PEG 600 ditallate, and
combinations thereof.
35. The composition of claim 22 wherein the ethoxylated fatty acid
surfactant is Mapeg S-40K.RTM..
36. The composition of claim 22 wherein the ethoxylated fatty acid
surfactant is Marlowet OTS.RTM..
37. The composition of claim 22 wherein the ethoxylated fatty acid
surfactant is Naturechem PGR.RTM..
38. The composition of claim 22 wherein the ethoxylated fatty acid
surfactant is PG No. 4.RTM..
39. The composition of claim 22 wherein the ethoxylated fatty acid
surfactant is Renex 20.RTM..
40. The composition of claim 22 wherein the ethoxylated fatty acid
surfactant is Ritox 52.RTM., Ritox 53.RTM., Ritox 59.RTM., or a
combination thereof.
41. The composition of claim 22 wherein the ethoxylated fatty acid
surfactant is Surfax 8916/A.RTM..
42. The composition of claim 22 wherein the ethoxylated fatty acid
surfactant is Tego Acid S 40 P.RTM..
43. The composition of claim 22 wherein the ethoxylated fatty acid
surfactant is Tego Acid S 100 P.RTM..
44. The composition of claim 22 wherein the ethoxylated fatty acid
surfactant is Tween 20.RTM..
45. The composition of claim 22 wherein the ethoxylated fatty acid
surfactant is Volpo 131.RTM..
46. The composition of claim 34 wherein the ethoxylated fatty acid
surfactant is PEG 200 monolaurate.
47. The composition of claim 34 wherein the ethoxylated fatty acid
surfactant is PEG 200 dilaurate.
48. The composition of claim 34 wherein the ethoxylated fatty acid
surfactant is PEG 400 monolaurate.
49. The composition of claim 34 wherein the ethoxylated fatty acid
surfactant is PEG 400 dilaurate.
50. The composition of claim 34 wherein the ethoxylated fatty acid
surfactant is PEG 600 mololaurate.
51. The composition of claim 34 wherein the ethoxylated fatty acid
surfactant is PEG 600 dilaurate.
52. The composition of claim 34 wherein the ethoxylated fatty acid
surfactant is PEG 200 monooleate.
53. The composition of claim 34 wherein the ethoxylated fatty acid
surfactant is PEG 200 dioleate.
54. The composition of claim 34 wherein the ethoxylated fatty acid
surfactant is PEG 400 monooleate.
55. The composition of claim 34 wherein the ethoxylated fatty acid
surfactant is PEG 400 dioleate.
56. The composition of claim 34 wherein the ethoxylated fatty acid
surfactant is PEG 600 monooleate.
57. The composition of claim 34 wherein the ethoxylated fatty acid
surfactant is PEG 600 dioleate.
58. The composition of claim 34 wherein the ethoxylated fatty acid
surfactant is PEG 200 monotallate.
59. The composition of claim 34 wherein the ethoxylated fatty acid
surfactant is PEG 200 ditallate.
60. The composition of claim 34 wherein the ethoxylated fatty acid
surfactant is PEG 400 monotallate.
61. The composition of claim 34 wherein the ethoxylated fatty acid
surfactant is PEG 400 ditallate.
62. The composition of claim 34 wherein the ethoxylated fatty acid
surfactant is PEG 600 monotallate.
63. The composition of claim 34 wherein the ethoxylated fatty acid
surfactant is PEG 600 ditallate.
Description
BACKGROUND
DESCRIPTION OF THE RELEVENT ART
[0001] Cyclosporins are a group of nonpolar cyclic oligopeptides
with known immunosuppressant activity. In addition, as set forth in
U.S. Pat. No. 4,839,342, cyclosporin (sometimes referred to in the
literature as "cyclosporine") has been found as effective in
treating immune medicated keratoconjunctivitis sicca (KCS or dry
eye disease) in a patient suffering therefrom.
[0002] As hereinabove noted, cyclosporin comprises a group of
cyclic oligopeptides and the major component thereof is cyclosporin
A (C.sub.62H.sub.111N.sub.11O.sub.12) which has been identified
along with several other minor metabolites, cyclosporin B through
I. In addition, a number of synthetic analogs have been
prepared.
[0003] In general, commercially available cyclosporins may contain
a mixture of several individual cyclosporins which all share a
cyclic peptide structure consisting of eleven amino acid residues
with a total molecular weight of about 1,200, but with different
substituents or configurations of some of the amino acids.
[0004] The activity of cyclosporins, as hereinabove noted, is as an
immunosuppressant and in the enhancement or restoring of lacrimal
gland tearing.
[0005] Unfortunately, the solubility of cyclosporin in water is
extremely low and as elaborated in U.S. Pat. No. 5,051,402, it has
been considered not merely difficult but practically impossible to
prepare a pharmaceutical composition containing cyclosporin
dissolved in an aqueous medium.
[0006] As reported, the solubility of cyclosporin in water is
between about 20 .mu.g/ml to 30 .mu.g/ml for cyclosporin A. Hence,
heretofore prepared formulations incorporating cyclosporin have
been prepared as oily solutions containing ethanol. However, these
preparations limit the bioavailability to oral preparations and
this is believed to be due to the separation of cyclosporin as a
solid immediately after it comes into contact with water, such as
in the mouth or eye of a patient.
[0007] Surface active agents such as polyoxyethylated castor oil
have been utilized as solubilizers to inject preparations in order
to prevent cyclosporin from separating. However, this also may give
rise to safety problems (see U.S. Pat. No. 5,051,402).
[0008] U.S. Pat. No. 5,474,979 discloses a pharmaceutical
composition in the form of a nonirritating emulsion which includes
at least one cyclosporin in admixture with a higher fatty acid
glyceride and polysorbate 80. More particularly, the cyclosporin
may be cyclosporin A and the higher fatty acid glyceride may be
castor oil.
[0009] U.S. Pat. No. 6,582,718 discloses an ophthalmic composition
particularly in the form of eye-drops suitable for the treatment of
diseases of the eye and surrounding areas. The composition contains
a cyclosporin and a surfactant selected from polyoxyethylene fatty
acid esters, polyoxyethylene alkylphenyl ethers and polyoxyethylene
alkyl ethers, or mixtures thereof.
[0010] Copending U.S. patent application No. 60/503,137, filed Sep.
15, 2003, and U.S. patent application No. 10/865,638, filed Jun. 9,
2004 also disclose compositions of interest.
DESCRIPTION OF THE INVENTION
[0011] A composition is disclosed herein comprising from about
0.001% to about 0.4% cyclosporin A, castor oil, and a surfactant
selected from the group consisting of alcohol ethoxylates,
alcohols, alkyl glycosides, alkyl polyglycosides, alkylphenol
ethoxylates, amine oxides, block polymers, carboxylated alcohol or
alkylphenol ethoxylates, carboxylic acids/fatty acids, cellulose
derivatives, ethoxylated alcohols, ethoxylated alkylphenols,
ethoxylated aryl phenols, ethoxylated fatty acids, ethoxylated
fatty acids, ethoxylated fatty esters and oils, fatty alcohols,
fatty esters, glycol esters, lanolin-based derivatives, lecithin
and lecithin derivatives, lignin and lignin derivatives, methyl
esters, monoglycerides and derivatives , phosphalipids, polyacrylic
acids, polyethylene glycols, polyethylene oxide-polypropylene oxide
copolymers, polyethylene oxides, polymeric surfactants,
polypropylene oxides, propoxylated alcohols, propoxylated alkyl
phenols, propoxylated fatty acids, protein-based surfactants,
sarcosine derivatives, silicone-based surfactants, sorbitan
derivatives, stearates, sucrose and glucose esters and derivatives,
and combinations thereof.
[0012] In certain embodiments, the composition is an ophthalmically
acceptable emulsion.
[0013] In one embodiment, the concentration of cyclosporin A is
from about 0.001% to about 0.1%.
[0014] While not intending to limit the scope of the invention in
any way, one type of useful surfactant is a sorbitan ester.
Examples include, but are not limited to, Polysorbate 20,
Polysorbate 40, Polysorbate 60, and Polysorbate 80.
[0015] While not intending to limit the scope of the invention in
any way, another type of useful surfactant is a stearate. Examples
include, but are not limited to, glyceryl stearate, isopropyl
stearate, polyoxyl stearate, propylene glycol stearate, and sucrose
stearate.
[0016] While not intending to limit the scope of the invention in
any way, another useful surfactant is polyethylene glycol.
[0017] While not intending to limit the scope of the invention in
any way. Other useful surfactants comprise polyethylene oxide or
polypropylene oxide. Examples, include, but are not limited to,
polyethylene oxides, polypropylene oxides, polyethylene oxide,
polypropylene oxide copolymers, alcohol ethoxylates, and
alkylphenol ethoxylates.
[0018] While not intending to limit the scope of the invention in
any way, another useful type of surfactant is an alkyl
glycoside.
[0019] While not intending to limit the scope of the invention in
any way, another useful type of surfactant is an alkyl
polyglycoside.
[0020] While not intending to limit the scope of the invention in
any way, another useful type of surfactant is a fatty alcohol.
[0021] While not intending to limit the scope of the invention in
any way, another useful type of surfactant is a cellulose
derivative, including, but not limited to, hydroxypropylmethyl
cellulose (HPMC) and carboxymethyl cellulose (CMC).
[0022] While not intending to limit the scope of the invention in
any way, another useful type of surfactant is a polyacrylic acid,
including, but not limited to, a Carbomer.
[0023] While not intending to limit the scope of the invention in
any way, another useful type of surfactant is a phosphalipid,
including, but not limited to, phosphatidyl chloline and
phosphatidyl serine.
[0024] Other useful surfactants include, but are not limited
to:
Alcohols, including but not limited to,
[0025] Diglycerol.RTM., which is available from Solvay Chemicals,
Inc.; [0026] Hetoxide GT-80.RTM., which is available from
Global-Seven, Inc.; [0027] Lexemul BEO.RTM., which is available
from Inolex Chemical Co.; [0028] Polyglycerol-3.RTM., which is
available from Solvay Chemicals, Inc.; [0029] Redicote E
Series.RTM., which is available from Akzo Nobel Surface Chemistry
LLC; [0030] Simulsol OX 1005L.RTM., which is available from Seppic
Inc.; [0031] Stanfax 567.RTM., which is available from Para-Chem
Standard Div.; [0032] TA-1618.RTM., which is available from Procter
& Gamble; [0033] Witconol H-31A.RTM., which is available from
Akzo Nobel Surface Chemistry LLC; and Standard Div.; Amine Oxides,
including but not limited to, [0034] AO-405.RTM., which is
available from Tomah Products.RTM., Inc.; [0035] AO-455.RTM., which
is available from Tomah Products.RTM., Inc.; [0036] AO 728
Special.RTM., which is available from Tomah Products.RTM., Inc.;
[0037] Barlox 12.RTM., which is available from Lonza Inc.; [0038]
Barlox 14.RTM., which is available from Lonza Inc.; [0039]
Burcoxide Lo.RTM., which is available from Burlington Chemical
Co..RTM., Inc.; [0040] Caloxamine LO.RTM., which is available from
Pilot Chemical Co.; [0041] Chemoxide CAW.RTM., which is available
from Chemron Corp.; [0042] Chemoxide LM-30.RTM., which is available
from Chemron Corp.; [0043] Chemoxide LO.RTM., which is available
from Chemron Corp.; [0044] Chemoxide MO.RTM., which is available
from Chemron Corp.; [0045] Colalux CAO-35.RTM., which is available
from Colonial Chemical Co.; [0046] Colalux LO.RTM., which is
available from Colonial Chemical Co.; [0047] DeMox CAPO.RTM., which
is available from DeForest Enterprises, Inc.; [0048] DeMox
CSG-30.RTM., which is available from DeForest Enterprises, Inc.;
[0049] DeMox LAO.RTM., which is available from DeForest
Enterprises, Inc.; [0050] Emcol L.RTM., which is available from
Crompton Corp.; [0051] Empigen OB.RTM., which is available from
Huntsman LLC; [0052] Empigen OS/A.RTM., which is available from
Huntsman LLC; [0053] Foamox CDO.RTM., which is available from Alzo
International, Inc.; [0054] Foamox DMM.RTM., which is available
from Alzo International, Inc.; [0055] Foamox DMS.RTM., which is
available from Alzo International, Inc.; [0056] Genaminox KC.RTM.,
which is available from Clariant Corporation; [0057] Genaminox
LA.RTM., which is available from Clariant Corporation; [0058]
Hartofoam SAO.RTM., which is available from Hart Chemical Corp.;
[0059] Hartox DMCD.RTM., which is available from Hart Chemical
Corp.; [0060] Lipowax DAT.RTM., ,which is available from Lipo
Chemicals, inc.; [0061] Lipowax PB Pastilles.RTM., which is
available from Lipo Chemicals, Inc.; [0062] Mackamine C8.RTM.,
which is available from The McIntyre Group; [0063] Mackamine
C10.RTM., which is available from The McIntyre Group; [0064]
Mackamine C14.RTM., which is available from The McIntyre Group;
[0065] Mackamine CAO.RTM., which is available from The McIntyre
Group; [0066] Mackamine CO.RTM., which is available from The
McIntyre Group; [0067] Mackamine LO.RTM., which is available from
The McIntyre Group; [0068] Mackamine 02.RTM., which is available
from The McIntyre Group; [0069] Mackamine SAO.RTM., which is
available from The McIntyre Group; [0070] Mackamine SO.RTM., which
is available from The McIntyre Group; [0071] Mazox KCAO.RTM., which
is available from BASF Corp.; [0072] Monalac MO.RTM., which is
available from Uniqema; [0073] Norfox LDA.RTM., which is available
from Norman, Fox & Co.; [0074] Rhodamox LC.RTM., which is
available from Rhodia, Inc.; [0075] Schercamox C-AA.RTM., which is
available from Noveon.RTM., Inc.; [0076] Schercamox DMA.RTM., which
is available from Noveon.RTM., Inc.; [0077] Schercamox DML.RTM.,
which is available from Noveon.RTM., Inc.; [0078] Schercamox
DMM.RTM., which is available from Noveon.RTM., Inc.; [0079]
Schercamox DMS.RTM., which is available from Noveon.RTM., Inc.;
[0080] Tegotens DC.RTM., which is available from Goldschmidt
Chemical Corp.; [0081] Tomah AO-14-2.RTM., which is available from
Tomah Products.RTM., Inc.; and [0082] Triaminox CDC.RTM., which is
available from Tri-Tex Co..RTM., Inc.; Block Polymers, including
but not limited to, [0083] AL 2070.RTM., which is available from
Uniqema; [0084] Antarox 17-R-2.RTM., which is available from
Rhodia, Inc.; [0085] Antarox 25-R-2.RTM., which is available from
Rhodia, Inc.; [0086] Antarox 31-R-1.RTM., which is available from
Rhodia, Inc.; [0087] Antarox P-84.RTM., which is available from
Rhodia, Inc.; [0088] Antarox P-104/H.RTM., which is available from
Rhodia, Inc.; [0089] Arnox BP-Series.RTM., which is available from
Crompton Corp.; [0090] Chemonic 435.RTM., which is available from
Chemron Corp.; [0091] Chemonic D-25.RTM., which is available from
Chemron Corp.; [0092] Chemonic PL Series.RTM., which is available
from Chemron Corp.; [0093] Ethox L-121.RTM., which is available
from Ethox Chemicals, LLC; [0094] Ethox L-122.RTM., which is
available from Ethox Chemicals, LLC; [0095] Genapol PF-10.RTM.,
which is available from Clariant Corporation; [0096] Genapol
PF-20.RTM., which is available from Clariant Corporation; [0097]
Genapol PF-40A.RTM., which is available from Clariant Corporation;
[0098] Norfox 2-LF.RTM., which is available from Norman, Fox &
Co.; [0099] Pluronic, which is available from BASF; [0100] Simulsol
NW 342.RTM., which is available from Seppic Inc.; [0101] T-Det
BP-1.RTM., which is available from Harcros Chemicals Inc.; [0102]
T-Det XD.RTM., which is available from Harcros Chemicals Inc.;
[0103] T-Det XH.RTM., which is available from Harcros Chemicals
Inc.; [0104] Triton CF-32.RTM., which is available from Dow
Chemical Company; [0105] Witconol 171.RTM., which is available from
Akzo Nobel Surface Chemistry LLC; [0106] Witconol 324.RTM., which
is available from Akzo Nobel Surface Chemistry LLC; [0107] Witconol
324D.RTM., which is available from Akzo Nobel Surface Chemistry
LLC; and [0108] Witconol PD-2000.RTM., which is available from Akzo
Nobel Surface Chemistry LLC; Carboxylated Alcohol or Alkylphenol
Ethoxylates, including but not limited to,
[0109] Emcol CN-6.RTM., which is available from Crompton Corp.;
[0110] Ethcarb.RTM., which is available from Ethox Chemicals, LLC;
[0111] Gemtex WNT-Conc.RTM., which is available from Finetex Inc.;
[0112] Incrodet TD7-C.RTM., which is available from Croda Inc.;
[0113] Marlinat CM 105/80.RTM., which is available from Sasol North
America Inc.; [0114] Marlowet 1072.RTM., which is available from
Sasol North America Inc.; [0115] Marlowet 4530.RTM., which is
available from Sasol North America Inc.; [0116] Marlowet 4530
LF.RTM., which is available from Sasol North America Inc.; [0117]
Marlowet 4534.RTM., which is available from Sasol North America
Inc.; [0118] Marlowet 4538.RTM., which is available from Sasol
North America Inc.; [0119] Marlowet 4539.RTM., which is available
from Sasol North America Inc.; [0120] Marlowet 4539 LF.RTM., which
is available from Sasol North America Inc.; [0121] Marlowet
4541.RTM., which is available from Sasol North America Inc.; [0122]
Miranate LEC-80.RTM., which is available from Rhodia, Inc.; [0123]
Sandopan B.RTM., which is available from Clariant Corporation;
[0124] Sandopan B Modified.RTM., which is available from Clariant
Corporation; [0125] Sandopan LS-24 Gel.RTM., which is available
from Clariant Corporation; and [0126] Surfine T-A.RTM., which is
available from Finetex Inc.; Carboxylic Acids/Fatty Acids,
including but not limited to, [0127] Colaterge RAM.RTM., which is
available from Colonial Chemical Co.; [0128] Colatrope INC.RTM.,
which is available from Colonial Chemical Co.; [0129] Crodacid
B.RTM., which is available from Croda Inc.; [0130] DeTrope
CA-100.RTM., which is available from DeForest Enterprises, Inc.;
[0131] Latol MTO.RTM., which is available from Georgia-Pacific
Corp.; [0132] Lumulse CC-33 K.RTM., which is available from Lambent
Technologies Corp.; [0133] Mulls 2218.RTM., which is available from
Bernel Chemical Co..RTM., Inc.; [0134] OL-600.RTM., which is
available from Procter & Gamble; [0135] OL-800.RTM., which is
available from Procter & Gamble; [0136] R-910.RTM., which is
available from Procter & Gamble; [0137] S-210.RTM., which is
available from Procter & Gamble; [0138] Sandopan DTC Acid.RTM.,
which is available from Clariant Corporation; [0139] Sandopan LS 24
N.RTM., which is available from Clariant Corporation; and [0140]
Sandopan MA-18.RTM., which is available from Clariant Corporation;
Ethoxylated Alcohols, including but not limited to, [0141] Adsee
799.RTM., which is available from Akzo Nobel Surface Chemistry LLC;
[0142] Adsee 799.RTM., which is available from Crompton Corp.;
[0143] Alfonic 610-3.5.RTM., which is available from Sasol North
America Inc.; [0144] Alfonic 810-2.RTM., which is available from
Sasol North America Inc.; [0145] Alfonic 810-6.RTM., which is
available from Sasol North America Inc.; [0146] Alfonic
1012-3.RTM., which is available from Sasol North America Inc.;
[0147] Alfonic 1012-5.RTM., which is available from Sasol North
America Inc.; [0148] Alfonic 1216CO-1.5.RTM., which is available
from Sasol North America Inc.; [0149] Alfonic 1216C0-7.RTM., which
is available from Sasol North America Inc.; [0150] Alfonic
1412-3.RTM., which is available from Sasol North America Inc.;
[0151] Alfonic 1412-7.RTM., which is available from Sasol North
America Inc.; [0152] Arlasolve 200.RTM., which is available from
Uniqema; [0153] Arlasolve 200 Liquid.RTM., which is available from
Uniqema; [0154] Armix 180-C.RTM., which is available from Crompton
Corp.; [0155] Armix 183.RTM., which is available from Crompton
Corp.; [0156] Armul 2404.RTM., which is available from Akzo Nobel
Surface Chemistry LLC; [0157] Armul 2404.RTM., which is available
from Crompton Corp.; [0158] Atlas EMJ-C.RTM., which is available
from Atlas Refinery Inc.; [0159] Atlas G-2109.RTM., which is
available from Uniqema; [0160] Atlas G-3886.RTM., which is
available from Uniqema; [0161] Atlas G-3890.RTM., which is
available from Uniqema; [0162] Bio Soft E-200.RTM., which is
available from Stepan Canada Inc.; [0163] Bio Soft E-300.RTM.,
which is available from Stepan Canada Inc.; [0164] Bio Soft
E-400.RTM., which is available from Stepan Canada Inc.; [0165] Bio
Soft EN 600.RTM., which is available from Stepan Canada Inc.;
[0166] Bio Soft TD-400.RTM., which is available from Stepan Canada
Inc.; [0167] Bio Soft TD-630.RTM., which is available from Stepan
Canada Inc.; [0168] Brij 30.RTM., which is available from Uniqema;
[0169] Brij 52.RTM., which is available from Uniqema; [0170] Brij
56.RTM., which is available from Uniqema; [0171] Brij 58.RTM.,
which is available from Uniqema; [0172] Brij 72.RTM., which is
available from Uniqema; [0173] Brij 76.RTM., which is available
from Uniqema; [0174] Brij 78.RTM., which is available from Uniqema;
[0175] Brij 93.RTM., which is available from Uniqema; [0176] Brij
97.RTM., which is available from Uniqema; [0177] Brij 98.RTM.,
which is available from Uniqema; [0178] Brij 700.RTM., which is
available from Uniqema; [0179] Brij 700 S.RTM., which is available
from Uniqema; [0180] Brij 721.RTM., which is available from
Uniqema; [0181] Brij 721 S.RTM., which is available from Uniqema;
[0182] Burcoterge CDG.RTM., which is available from Burlington
Chemical Co..RTM., Inc.; [0183] Canasol AT 600.RTM., which is
available from Canamex Quimicos S.A de C.v; [0184] Canasol AT
800.RTM., which is available from Canamex Quimicos S.A de C.v;
[0185] Canasol AT 1200.RTM., which is available from Canamex
Quimicos S.A de C.v; [0186] Canasol BJ 35.RTM., which is available
from Canamex Quimicos S.A de C.v; [0187] Canasol BJ 36.RTM., which
is available from Canamex Quimicos S.A de C.v; [0188] Canasol BJ
52.RTM., which is available from Canamex Quimicos S.A de C.v;
[0189] Canasol BJ 58.RTM., which is available from Canamex Quimicos
S.A de C.v; [0190] Canasol BJ 72.RTM., which is available from
Canamex Quimicos S.A de C.v; [0191] Canasol BJ 78.RTM., which is
available from Canamex Quimicos S.A de C.v; [0192] Canasol BJ
98.RTM., which is available from Canamex Quimicos S.A de C.v;
[0193] Canasol BJ 307.RTM., which is available from Canamex
Quimicos S.A de C.v; [0194] Cerfak 1400.RTM., which is available
from Houghton International Inc.; [0195] Cetomacrogol 1000 BP.RTM.,
which is available from Croda Inc.; [0196] Chemonic C-2.RTM., which
is available from Chemron Corp.; [0197] Chemonic C-10.RTM., which
is available from Chemron Corp.; [0198] Chemonic C-20.RTM., which
is available from Chemron Corp.; [0199] Chemonic CT-12.RTM., which
is available from Chemron Corp.; [0200] Chemonic CT-20.RTM., which
is available from Chemron Corp.; [0201] Chemonic CT-30.RTM., which
is available from Chemron Corp.; [0202] Chemonic CT-55.RTM., which
is available from Chemron Corp.; [0203] Chemonic G-7.RTM., which is
available from Chemron Corp.; [0204] Chemonic G-26.RTM., which is
available from Chemron Corp.; [0205] Chemonic L-4.RTM., which is
available from Chemron Corp.; [0206] Chemonic L-7.RTM., which is
available from Chemron Corp.; [0207] Chemonic L-12.RTM., which is
available from Chemron Corp.; [0208] Chemonic L-23.RTM., which is
available from Chemron Corp.; [0209] Chemonic O-2.RTM., which is
available from Chemron Corp.; [0210] Chemonic O-5.RTM., which is
available from Chemron Corp.; [0211] Chemonic O-10.RTM., which is
available from Chemron Corp.; [0212] Chemonic O-20.RTM., which is
available from Chemron Corp.; [0213] Chemonic S-2.RTM., which is
available from Chemron Corp.; [0214] Chemonic S-10.RTM., which is
available from Chemron Corp.; [0215] Chemonic S-20.RTM.; which is
available from Chemron Corp.; [0216] Colamulse FE.RTM., which is
available from Colonial Chemical Co.; [0217] Cremophor A 20.RTM.,
which is available from BASF Corp.; [0218] Cremophor SA 2.RTM.,
which is available from BASF Corp.; [0219] Dehydol 100.RTM., which
is available from Cognis Canada Corp.; [0220] Dehydol O-4.RTM.,
which is available from Cognis Canada Corp.; [0221] Delonic
C-18.RTM., which is available from DeForest Enterprises, Inc.;
[0222] DeSonic 6T.RTM., which is available from Crompton Corp.;
[0223] DeSonic 9D.RTM., which is available from Crompton Corp.;
[0224] DeSonic 9T.RTM., which is available from Crompton Corp.;
[0225] DeSonic 12D.RTM., which is available from Crompton Corp.;
[0226] DeSonic 12T.RTM., which is available from Crompton Corp.;
[0227] DeSonic 15T.RTM., which is available from Crompton Corp.;
[0228] DeSonic TDA-9.RTM., which is available from Crompton Corp.;
[0229] DeThox GLG-7.RTM., which is available from DeForest
Enterprises, Inc.; [0230] DeThox GLG-26.RTM., which is available
from DeForest Enterprises, Inc.; [0231] DeThox LA-4.RTM., which is
available from DeForest Enterprises, Inc.; [0232] DeThox
LA-23.RTM., which is available from DeForest Enterprises, Inc.;
[0233] DeThox SA-80.RTM., which is available from DeForest
Enterprises, Inc.; [0234] Disponil O5.RTM., which is available from
Cognis Corporation; [0235] Eccoterge EO-41B.RTM., which is
available from Eastern Color & Chemical Co.; [0236] Empilan
KA2.5/90.RTM., which is available from Huntsman LLC; [0237] Empilan
KA5/90.RTM., which is available from Huntsman LLC; [0238] Empilan
KM-20.RTM., which is available from Huntsman LLC; [0239] Empilan
KM-50.RTM., which is available from Huntsman LLC; [0240] Empilan
L-23.RTM., which is available from Huntsman LLC; [0241] Ethylan
25-3.RTM., which is available from Akzo Nobel Surface Chemistry
LLC; [0242] Ethylan 1204.RTM., which is available from Akzo Nobel
Surface Chemistry LLC; [0243] Ethylan DA-4.RTM., which is available
from Akzo Nobel Surface Chemistry LLC; [0244] Ethylan LA-230.RTM.,
which is available from Akzo Nobel Surface Chemistry LLC; [0245]
Ethylan SN.RTM., which is available from Akzo Nobel Surface
Chemistry LLC; [0246] Ethylan TD-60.RTM., which is available from
Akzo Nobel Surface Chemistry LLC; [0247] Ethylan TD-100.RTM., which
is available from Akzo Nobel Surface Chemistry LLC; [0248] Ethylan
TD-1407.RTM., which is available from Akzo Nobel Surface Chemistry
LLC; [0249] Eumulgin B1.RTM., which is available from Cognis Canada
Corp.; [0250] Eumulgin B2.RTM., which is available from Cognis
Canada Corp.; [0251] Eumulgin B3.RTM., which is available from
Cognis Canada Corp.; [0252] Eumulgin O-10.RTM., which is available
from Cognis Canada Corp.; [0253] Flo Mo 80/20.RTM., which is
available from Crompton Corp.; [0254] Flo Mo Low Foam.RTM., which
is available from Crompton Corp.; [0255] Forlan C-24.RTM., which is
available from RITA Corp.; [0256] Genapol 1454.RTM., which is
available from Clariant Corporation; [0257] Genapol BA-020.RTM.,
which is available from Clariant Corporation; [0258] Genapol
BA-040.RTM., which is available from Clariant Corporation; [0259]
Genapol C-100.RTM., which is available from Clariant Corporation;
[0260] Genapol DA 060.RTM., which is available from Clariant
Corporation; [0261] Genapol HS 020.RTM., which is available from
Clariant Corporation; [0262] Genapol HS 200.RTM., which is
available from Clariant Corporation; [0263] Genapol ID-040.RTM.,
which is available from Clariant Corporation; [0264] Genapol
ID-060.RTM., which is available from Clariant Corporation; [0265]
Genapol ID-090.RTM., which is available from Clariant Corporation;
[0266] Genapol LA 010.RTM., which is available from Clariant
Corporation; [0267] Genapol LA 020.RTM., which is available from
Clariant Corporation; [0268] Genapol LA 030.RTM., which is
available from Clariant Corporation; [0269] Genapol LA 040.RTM.,
which is available from Clariant Corporation; [0270] Genapol LA
050.RTM., which is available from Clariant Corporation; [0271]
Genapol LA 060.RTM., which is available from Clariant Corporation;
[0272] Genapol LA 070.RTM., which is available from Clariant
Corporation; [0273] Genapol LA 070S.RTM., which is available from
Clariant Corporation; [0274] Genapol LA 230.RTM., which is
available from Clariant Corporation; [0275] Genapol O020.RTM.,
which is available from Clariant Corporation; [0276] Genapol
O050.RTM., which is available from Clariant Corporation; [0277]
Genapol O100.RTM., which is available from Clariant Corporation;
[0278] Genapol O200.RTM., which is available from Clariant
Corporation; [0279] Genapol SA 030.RTM., which is available from
Clariant Corporation; [0280] Genapol SA 120.RTM., which is
available from Clariant Corporation; [0281] Genapol T-020.RTM.,
which is available from Clariant Corporation; [0282] Genapol
UD-030.RTM., which is available from Clariant Corporation; [0283]
Genapol UD-050.RTM., which is available from Clariant Corporation;
[0284] Genapol UD-070.RTM., which is available from Clariant
Corporation; [0285] Genapol UD-079.RTM., which is available from
Clariant Corporation; [0286] Genapol UD-080.RTM., which is
available from Clariant Corporation; [0287] Genapol UD-110.RTM.,
which is available from Clariant Corporation; [0288] Genapol X
030.RTM., which is available from Clariant Corporation; [0289]
Genapol X 050.RTM., which is available from Clariant Corporation;
[0290] Genapol X 060.RTM., which is available from Clariant
Corporation; [0291] Genapol X 070.RTM., which is available from
Clariant Corporation; [0292] Genapol X 080.RTM., which is available
from Clariant Corporation; [0293] Genapol X 100.RTM., which is
available from Clariant Corporation; [0294] Genapol X159.RTM.,
which is available from Clariant Corporation; [0295] Generol 122
E5.RTM., which is available from Cognis Canada Corp.; [0296]
Generol 122 E25.RTM., which is available from Cognis Canada Corp.;
[0297] Hostacerin T-3.RTM., which is available from Clariant
Corporation; [0298] Iconol LF 110.RTM., which is available from
BASF Corp.; [0299] Incropol CS-20.RTM., which is available from
Croda Inc.; [0300] Lexemul CS-20.RTM., which is available from
Inolex Chemical Co.; [0301] Liponic EG-1.RTM., which is available
from Lipo Chemicals, Inc.; [0302] Lipowax D.RTM., which is
available from Lipo Chemicals, Inc.; [0303] Lipowax G.RTM., which
is available from Lipo Chemicals, Inc.; [0304] Lipowax NI.RTM.,
which is available from Lipo Chemicals, Inc.; [0305] Lipowax
P.RTM., which is available from Lipo Chemicals, Inc.; [0306]
Lipowax P-31.RTM., which is available from Lipo Chemicals, Inc.;
[0307] Lipowax PR.RTM., which is available from Lipo Chemicals,
Inc.; [0308] Lumulse CS-20.RTM., which is available from Lambent
Technologies Corp.; [0309] Macol CSA-20.RTM., which is available
from BASF Corp.; [0310] Marlox B 24/50.RTM., which is available
from Sasol North America Inc.; [0311] Mazawet 77.RTM., which is
available from BASF Corp.; [0312] Norfox 1713.RTM., which is
available from Norman, Fox
& Co.; [0313] Norfox 2579.RTM., which is available from Norman,
Fox & Co.; [0314] Norfox Lo Foam.RTM., which is available from
Norman, Fox & Co.; [0315] Promulgen D.RTM., which is available
from Amerchol Corp.; [0316] Promulgen G.RTM., which is available
from Amerchol Corp.; [0317] Renex 30.RTM., which is available from
Uniqema; [0318] Renex 36.RTM., which is available from Uniqema;
[0319] Rhodasurf A 24.RTM., which is available from Rhodia, Inc.;
[0320] RhodasunA AAE-10.RTM., which is available from Rhodia, Inc.;
[0321] Rhodasun BEH-25.RTM., which is available from Rhodia, Inc.;
[0322] Rhodasurf BEH-40.RTM., which is available from Rhodia, Inc.;
[0323] Rhodasurf DA 530.RTM., which is available from Rhodia, Inc.;
[0324] Rhodasurf DA 630.RTM., which is available from Rhodia, Inc.;
[0325] Rhodasurf DA 639.RTM., which is available from Rhodia, Inc.;
[0326] Rhodasurf LAN-23.RTM., which is available from Rhodia, Inc.;
[0327] Rhodasurf ON-870.RTM., which is available from Rhodia, Inc.;
[0328] Rhodasurf ON-877.RTM., which is available from Rhodia, Inc.;
[0329] Rhodasun TB-970 FLK.RTM., which is available from Rhodia,
Inc.; [0330] Ritacet-20.RTM., which is available from RITA Corp.;
[0331] Ritachol 1000.RTM., which is available from RITA Corp.;
[0332] Ritachol 2000.RTM., which is available from RITA Corp.;
[0333] Ritachol 5000.RTM., which is available from RITA Corp.;.
[0334] Ritox 35.RTM., which is available from RITA Corp.; [0335]
Sunfonic DA-4.RTM., which is available from Huntsman LLC; [0336]
Surfonic DA-6.RTM., which is available from Huntsman LLC; [0337]
Surfonic L46-7.RTM., which is available from Huntsman LLC; [0338]
Surfonic POA.RTM., which is available from Huntsman LLC; [0339]
Synthrapol KB.RTM., which is available from Uniqema; [0340]
Teginacid.RTM., which is available from Goldschmidt Chemical Corp.;
[0341] Teginacid C.RTM., which is available from Goldschmidt
Chemical Corp.; [0342] Tegotens EC 11.RTM., which is available from
Goldschmidt Chemical Corp.; [0343] Tinegal NA.RTM., which is
available from Ciba Specialty Chemicals Corp.; [0344] Tomadol
400.RTM., which is available from Tomah Products.RTM., Inc.; [0345]
Tomadol 600.RTM., which is available from Tomah Products.RTM.,
Inc.; [0346] Tomadol 900.RTM., which is available from Tomah
Products.RTM., Inc.; [0347] Uniperol O.RTM., which is available
from BASF Corp.; [0348] Witconol SN Series.RTM., which is available
from Crompton Corp.; Ethoxylated Alkylphenols, including but not
limited to, [0349] Antarox LF-222.RTM., which is available from
Rhodia, Inc.; [0350] Atlox 775.RTM., which is available from
Uniqema; [0351] Caloxylate N-9.RTM., which is available from Pilot
Chemical Co.; [0352] Canasol NF-1000.RTM., which is available from
Canamex Quimicos S.A de C.v; [0353] Canasol NF-3000.RTM., which is
available from Canamex Quimicos S.A de C.v; [0354] Canasol
NF-3070.RTM., which is available from Canamex Quimicos S.A de C.v;
[0355] Canasol OF 1670.RTM., which is available from Canamex
Quimicos S.A de C.v; [0356] Canasol OF 2570.RTM., which is
available from Canamex Quimicos S.A de C.v; [0357] Canasol OF
4070.RTM., which is available from Canamex Quimicos S.A de C.v;
[0358] Chemax DNP-8.RTM., which is available from Chemax
Performance Solutions; [0359] Chemax DNP-18.RTM., which is
available from Chemax Performance Solutions; [0360] Chemax
DNP-150/50.RTM., which is available from Chemax Performance
Solutions; [0361] DeSonic 1.5N.RTM., which is available from
Crompton Corp.; [0362] DeSonic 4N.RTM., which is available from
Crompton Corp.; [0363] DeSonic 5N.RTM., which is available from
Crompton Corp.; [0364] DeSonic 6D.RTM., which is available from
Crompton Corp.; [0365] DeSonic 6N.RTM., which is available from
Crompton Corp.; [0366] DeSonic 7N.RTM., which is available from
Crompton Corp.; [0367] DeSonic 9N.RTM., which is available from
Crompton Corp.; [0368] DeSonic 10D.RTM., which is available from
Crompton Corp.; [0369] DeSonic 11N.RTM., which is available from
Crompton Corp.; [0370] DeSonic 12N.RTM., which is available from
Crompton Corp.; [0371] DeSonic 15N.RTM., which is available from
Crompton Corp.; [0372] DeSonic 20N.RTM., which is available from
Crompton Corp.; [0373] Eccoscour RC.RTM., which is available from
Eastern Color & Chemical Co.; [0374] Eccoterge EO-10.RTM.,
which is available from Eastern Color & Chemical Co.; [0375]
Emulsifier 632/90% .RTM., which is available from Ethox Chemicals,
LLC; [0376] Geronol AG-821.RTM., which is available from Rhodia,
Inc.; [0377] Gradonic N-95.RTM., which is available from Graden
Chemical Co. Inc.; [0378] Hetoxide NP-4.RTM., which is available
from Global-Seven, Inc.; [0379] Hetoxide NP-30.RTM., which is
available from Global-Seven, Inc.; [0380] Hostapal N-100.RTM.,
which is available from Clariant Corporation; [0381] Hostapal
N-110.RTM., which is available from Clariant Corporation; [0382]
Igepal CTA-639W.RTM., which is available from Rhodia, Inc.; [0383]
Igepal DAP-9.RTM., which is available from Rhodia, Inc.; [0384]
Igepal OD-410.RTM., which is available from Rhodia, Inc.; [0385]
Igepal SS-837.RTM., which is available from Rhodia, Inc.; [0386]
Lipocol NP-9 USP.RTM., which is available from Lipo Chemicals,
Inc.; [0387] Macol DNP-10.RTM., which is available from BASF Corp.;
[0388] Marlophen NP 5.RTM., which is available from Sasol North
America Inc.; [0389] Marlophen P 1.RTM., which is available from
Sasol North America Inc.; [0390] Surfonic NB.RTM., which is
available from Huntsman LLC; [0391] Surfonic OPB-307.RTM., which is
available from Huntsman LLC; [0392] Surfonic OPB-407.RTM., which is
available from Huntsman LLC; [0393] Syn Fac 334.RTM., which is
available from Milliken Chemical; [0394] Syn Fac 8216.RTM., which
is available from Milliken Chemical; [0395] Triton N-57.RTM., which
is available from Dow Chemical Company; [0396] Trycol 6956.RTM.,
which is available from Cognis Corporation; [0397] Trycol
6961.RTM., which is available from Cognis Corporation; [0398]
Trycol 6964.RTM., which is available from Cognis Corporation;
[0399] Trycol 6969.RTM., which is available from Cognis
Corporation; [0400] Trycol 6974.RTM., which is available from
Cognis Corporation; [0401] Witbreak DRB-127.RTM., which is
available from Akzo Nobel Surface Chemistry LLC; [0402] Witbreak
DRB-127.RTM., which is available from Crompton Corp.; and [0403]
Witconol NP Series.RTM., which is available from Akzo Nobel Surface
Chemistry LLC; Ethoxylated Aryl Phenols, including but not limited
to, [0404] Soprophor BSU.RTM., which is available from Rhodia,
Inc.; [0405] Soprophor CY/8.RTM., which is available from Rhodia,
Inc.; [0406] Soprophor S/25.RTM., which is available from Rhodia,
Inc.; [0407] Witconol NIO.RTM., which is available from Akzo Nobel
Surface Chemistry LLC; [0408] Witconol NIW.RTM., which is available
from Akzo Nobel Surface Chemistry LLC; and [0409] Witconol
S-100.RTM., which is available from Akzo Nobel Surface Chemistry
LLC; Ethoxylated Fatty Acids, including but not limited to, [0410]
Aldo PGHMS.RTM., which is available from Lonza Inc.; [0411]
Alkamuls TO-15/HR.RTM., which is available from Rhodia, Inc.;
[0412] Armotan AL-69-66.RTM., which is available from Akzo Nobel
Surface Chemistry LLC; [0413] Cerasynt 840.RTM., which is available
from International Specialty Products/IS; [0414] Cerasynt 945.RTM.,
which is available from International Specialty Products/IS; [0415]
Crystal Inhibitor No. 5.RTM., which is available from Harcros
Chemicals Inc.; [0416] DeThox Acid L-9.RTM., which is available
from DeForest Enterprises, Inc.; [0417] DeThox Acid S-8.RTM., which
is available from DeForest Enterprises, Inc.; [0418] Ethofat
242/25.RTM., which is available from Akzo Nobel Surface Chemistry
LLC; [0419] Hydropalat 65.RTM., which is available from Cognis
Corporation; [0420] Lipo EGMS.RTM., which is available from Lipo
Chemicals, Inc.; [0421] Lipopeg 2 DL.RTM., which is available from
Lipo Chemicals, Inc.; [0422] Lipopeg 4 DL.RTM., which is available
from Lipo Chemicals, Inc.; [0423] Lipopeg 4-L.RTM., which is
available from Lipo Chemicals, Inc.; [0424] Lipopeg 39-S.RTM.,
which is available from Lipo Chemicals, Inc.; [0425] Lipopeg
4-S.RTM., which is available from Lipo Chemicals, Inc.; [0426]
Lipopeg 10-S.RTM., which is available from Lipo Chemicals, Inc.;
[0427] Lipopeg 100-S.RTM., which is available from Lipo Chemicals,
Inc.; [0428] Lipopeg 6000 DS.RTM., which is available from Lipo
Chemicals, Inc.; [0429] Lumulse 40-L.RTM., which is available from
Lambent Technologies Corp.; [0430] Lumulse 40-S.RTM., which is
available from Lambent Technologies Corp.; [0431] Lumulse
42-L.RTM., which is available from Lambent Technologies Corp.;
[0432] Lumulse 42-S.RTM., which is available from Lambent
Technologies Corp.; [0433] Lumulse 100-S.RTM., which is available
from Lambent Technologies Corp.; [0434] Lumulse 602-S.RTM., which
is available from Lambent Technologies Corp.; [0435] Magrabar
PGE-20-0.RTM., which is available from Magrabar Chemical Corp.;
[0436] Magrabar PGE-20L.RTM., which is available from Magrabar
Chemical Corp.; [0437] Magrabar PGE-20T.RTM., which is available
from Magrabar Chemical Corp.; [0438] Magrabar PGE-22-0.RTM., which
is available from Magrabar Chemical Corp.; [0439] Magrabar
PGE-22L.RTM., which is available from Magrabar Chemical Corp.;
[0440] Magrabar PGE-22T.RTM., which is available from Magrabar
Chemical Corp.; [0441] Magrabar PGE-40-0.RTM., which is available
from Magrabar Chemical Corp.; [0442] Magrabar PGE-40L.RTM., which
is available from Magrabar Chemical Corp.; [0443] Magrabar
PGE-40T.RTM., which is available from Magrabar Chemical Corp.;
[0444] Magrabar PGE-42-0.RTM., which is available from Magrabar
Chemical Corp.; [0445] Magrabar PGE-42L.RTM., which is available
from Magrabar Chemical Corp.; [0446] Magrabar PGE-42T.RTM., which
is available from Magrabar Chemical Corp.; [0447] Magrabar
PGE-60-0.RTM., which is available from Magrabar Chemical Corp.;
[0448] Magrabar PGE-60L.RTM., which is available from Magrabar
Chemical Corp.; [0449] Magrabar PGE-60T.RTM., which is available
from Magrabar Chemical Corp.; [0450] Magrabar PGE-62-0.RTM., which
is available from Magrabar Chemical Corp.; [0451] Magrabar
PGE-62L.RTM., which is available from Magrabar Chemical Corp.;
[0452] Magrabar PGE-62T.RTM., which is available from Magrabar
Chemical Corp.; [0453] Mapeg S-40K.RTM., which is available from
BASF Corp.; [0454] Marlowet OTS.RTM., which is available from Sasol
North America Inc.; [0455] Naturechem PGR.RTM., which is available
from CasChem.RTM., Inc.; [0456] PG No. 4.RTM., which is available
from Hart Chemical Corp.; [0457] Renex 20.RTM., which is available
from Uniqema; [0458] Ritox 52.RTM., which is available from RITA
Corp.; [0459] Ritox 53.RTM., which is available from RITA Corp.;
[0460] Ritox 59.RTM., which is available from RITA Corp.; [0461]
Surfax 8916/A.RTM., which is available from Houghton International
Inc.; [0462] Tego Acid S 40 P.RTM., which is available from
Goldschmidt Chemical Corp.; [0463] Tego Acid S 100 P.RTM., which is
available from Goldschmidt Chemical Corp.; [0464] Tween 20.RTM.,
which is available from Uniqema; and [0465] Volpo 131.RTM., which
is available from Croda Inc.; Ethoxylated Fatty Esters or Oils
(Animal & Veg.), including but not limited to, [0466] Acconon
6-C10.RTM., which is available from Abitec Corporation; [0467]
Acconon CC-6.RTM., which is available from Abitec Corporation;
[0468] Acconon CO-7.RTM., which is available from Abitec
Corporation; [0469] Aldosperse 40/60 FG.RTM., which is available
from Lonza Inc.; [0470] Aldosperse ML-23.RTM., which is available
from Lonza Inc.; [0471] Aldosperse MS-20 FG.RTM., which is
available from Lonza Inc.; [0472] Alkamuls EL-620.RTM., which is
available from Rhodia, Inc.; [0473] Alkamuls EL-719.RTM., which is
available from Rhodia, Inc.; [0474] Alkamuls EL-985.RTM., which is
available from Rhodia, Inc.; [0475] Arlatone G.RTM., which is
available from Uniqema; [0476] Arlatone T.RTM., which is available
from Uniqema; [0477] Atlas G-1045A.RTM., which is available from
Uniqema; [0478] Atlas G-1086.RTM., which is available from Uniqema;
[0479] Atlas G-1087.RTM., which is available from Uniqema; [0480]
Atlas G-1089.RTM., which is available from Uniqema; [0481] Atlas
G-1096.RTM., which is available from Uniqema; [0482] Atlas
G-1292.RTM., which is available from Uniqema; [0483] Atlas
G-1293.RTM., which is available from Uniqema; [0484] Atlas
G-1300.RTM., which is available from Uniqema; [0485] Atlas
G-7076.RTM., which is available from Uniqema; [0486] Capmul
EMG.RTM., which is available from Abitec Corporation; [0487]
Chemonic CO-40.RTM., which is available from Chemron Corp.; [0488]
Chemonic LI-3.RTM., which is available from Chemron Corp.; [0489]
Chemonic LI-7.RTM., which is available from Chemron Corp.; [0490]
Cirrasol GM.RTM., which is available from Uniqema; [0491] Cremophor
CO 40.RTM., which is available from BASF Corp.; [0492] Cremophor CO
410.RTM., which is available from BASF Corp.; [0493] Cremophor
EL.RTM., which is available from BASF Corp.; [0494] Cremophor
GC7.RTM., which is available from BASF Corp.; [0495] Cremophor
RH-40.RTM., which is available from BASF Corp.; [0496] Crovol
A-40.RTM., which is available from Croda Inc.; [0497] Crovol
A-70.RTM., which is available from Croda Inc.; [0498] Crovol
M-70.RTM., which is available from Croda Inc.; [0499] Crovol
PK-70.RTM., which is available from Croda Inc.; [0500] Cutina
E-24.RTM., which is available from Cognis Canada Corp.; [0501]
Dacospin 12-R.RTM., which is available from Cognis Corporation;
[0502] Dehymuls HRE-7.RTM., which is available from Cognis
Corporation; [0503] DeSonic 30C.RTM., which is available from
Crompton Corp.; [0504] DeSonic 36C.RTM., which is available from
Crompton Corp.; [0505] DeSonic 40C.RTM., which is available from
Crompton Corp.; [0506] Durfax 60.RTM., which is available from
Loders Croklaan U.S.A.; [0507] Durfax 65.RTM., which is available
from Loders Croklaan U.S.A.; [0508] Durfax 80.RTM., which is
available from Loders Croklaan U.S.A.; [0509] Durfax EOM.RTM.,
which is available from Loders Croklaan U.S.A.; [0510] Eccoterge
NF-2.RTM., which is available from Eastern Color & Chemical
Co.; [0511] Emulpon CO-360.RTM., which is available from Akzo Nobel
Surface Chemistry LLC; [0512] Emulpon CO-550.RTM., which is
available from Akzo Nobel Surface Chemistry LLC; [0513] Emulsogen
EL.RTM., which is available from Clariant Corporation; [0514]
Emulsogen HCO 040.RTM., which is available from Clariant
Corporation; [0515] Emulsogen HCO 060.RTM., which is available from
Clariant Corporation;
[0516] Emulsynt 1055.RTM., which is available from International
Specialty Products/IS; [0517] Ethox 3095.RTM., which is available
from Ethox Chemicals, LLC; [0518] Eumulgin RO-40.RTM., which is
available from Cognis Canada Corp.; [0519] Genapol G-260.RTM.,
which is available from Clariant Corporation; [0520] Glycosperse
L-20.RTM., which is available from Lonza Inc.; [0521] Glycosperse
O-5.RTM., which is available from Lonza Inc.; [0522] Glycosperse
O-20.RTM., which is available from Lonza Inc.; [0523] Glycosperse
O-20 FG.RTM., which is available from Lonza Inc.; [0524]
Glycosperse S-20.RTM., which is available from Lonza Inc.; [0525]
Glycosperse S-20 FG.RTM., which is available from Lonza Inc.;
[0526] Glycosperse TS-20.RTM., which is available from Lonza Inc.;
[0527] Glycosperse TS-20 FG.RTM., which is available from Lonza
Inc.; [0528] Hetan SL.RTM., which is available from Global-Seven,
Inc.; [0529] Hetan SO.RTM., which is available from Global-Seven,
Inc.; [0530] Hetan SS.RTM., which is available from Global-Seven,
Inc.; [0531] Hetoxide C-2.RTM., which is available from
Global-Seven, Inc.; [0532] Hetoxide C-9.RTM., which is available
from Global-Seven, Inc.; [0533] Hetoxide C-15.RTM., which is
available from Global-Seven, Inc.; [0534] Hetoxide C-25.RTM., which
is available from Global-Seven, Inc.; [0535] Hetoxide C-40.RTM.,
which is available from Global-Seven, Inc.; [0536] Hetoxide
C-200.RTM., which is available from Global-Seven, Inc.; [0537]
Hetoxide C-200-50% .RTM., which is available from Global-Seven,
Inc.; [0538] Hetoxide GC-30.RTM., which is available from
Global-Seven, Inc.; [0539] Hetoxide HC-60.RTM., which is available
from Global-Seven, Inc.; [0540] Ice No. 2.RTM., which is available
from Loders Croklaan U.S.A.; [0541] Incrocas 30/40.RTM., which is
available from Croda Inc.; [0542] Lexol EC.RTM., which is available
from Inolex Chemical Co.; [0543] Lexol EO.RTM., which is available
from Inolex Chemical Co.; [0544] Lipocol HCO-40.RTM., which is
available from Lipo Chemicals, Inc.; [0545] Lipocol HCO-60.RTM.,
which is available from Lipo Chemicals, Inc.; [0546] Lipocol O-3
Special.RTM., which is available from Lipo Chemicals, Inc.; [0547]
Lipopeg 2-L.RTM., which is available from Lipo Chemicals, Inc.;
[0548] Lipopeg 4-DO.RTM., which is available from Lipo Chemicals,
Inc.; [0549] Lipopeg 4-DS.RTM., which is available from Lipo
Chemicals, Inc.; [0550] Lipovol GTB.RTM., which is available from
Lipo Chemicals, Inc.; [0551] Lonzest SML-20.RTM., which is
available from Lonza Inc.; [0552] Lonzest SMO-20.RTM., which is
available from Lonza Inc.; [0553] Lonzest SMS-20.RTM., which is
available from Lonza Inc.; [0554] Lonzest STO-20.RTM., which is
available from Lonza Inc.; [0555] Lonzest STS-20.RTM., which is
available from Lonza Inc.; [0556] Lumulse GR-40.RTM., which is
available from Lambent Technologies Corp.; [0557] Lumulse
GRH-40.RTM., which is available from Lambent Technologies Corp.;
[0558] Lumulse POE (7) GML.RTM., which is available from Lambent
Technologies Corp.; [0559] Lumulse POE (12) Glyc.RTM., which is
available from Lambent Technologies Corp.; [0560] Lumulse POE (40)
MS KP.RTM., which is available from Lambent Technologies Corp.;
[0561] Marlowet 4750.RTM., which is available from Sasol North
America Inc.; [0562] Marlowet LVS.RTM., which is available from
Sasol North America Inc.; [0563] Marlowet R 11.RTM., which is
available from Sasol North America Inc.; [0564] Marlowet R 40.RTM.,
which is available from Sasol North America Inc.; [0565] Mazol 80
MGK.RTM., which is available from BASF Corp.; [0566] Nonionic
Emulsifier T-9.RTM., which is available from Werner G. Smith Inc.;
[0567] Oronal LCG.RTM., which is available from Seppic Inc.; [0568]
Polyderm PPI-CO-200.RTM., which is available from Alzo
International, Inc.; [0569] Polyderm PPI-CO-40.RTM., which is
available from Alzo International, Inc.; [0570] Rewoderm LI
520-70.RTM., which is available from Goldschmidt Chemical Corp.;
[0571] Ritapeg 150 DS.RTM., which is available from RITA Corp.;
[0572] Softigen 767.RTM., which is available from Sasol North
America Inc.; [0573] Surfactol 318.RTM., which is available from
CasChem.RTM., Inc.; [0574] Surfactol 365.RTM., which is available
from CasChem.RTM., Inc.; [0575] Syn Lube 107.RTM., which is
available from Milliken Chemical; [0576] Syn Lube 728.RTM., which
is available from Milliken Chemical; [0577] Syn Lube 1632H.RTM.,
which is available from Milliken Chemical; [0578] Syn Lube
6277-A.RTM., which is available from Milliken Chemical; [0579]
T-Det C-20.RTM., which is available from Harcros Chemicals Inc.;
[0580] T-Det C-40.RTM., which is available from Harcros Chemicals
Inc.; [0581] Tally 100 Plus.RTM., which is available from Loders
Croklaan U.S.A.; and [0582] Uniperol EL.RTM., which is available
from BASF Corp.; Fatty Esters, including but not limited to, [0583]
Actralube-Syn 147.RTM., which is available from Georgia-Pacific
Corp.; [0584] Atlas G-1556.RTM., which is available from Uniqema;
[0585] Atlas G-1564.RTM., which is available from Uniqema; [0586]
Atlasol Base Oil S.RTM., which is available from Atlas Refinery
Inc.; [0587] Base ML.RTM., which is available from Keil Chemical;
[0588] Base MT.RTM., which is available from Keil Chemical; [0589]
Cerasynt 303.RTM., which is available from International Specialty
Products/IS; [0590] Dermol 1012.RTM., which is available from Alzo
International, Inc.; [0591] Kemester 4000.RTM., which is available
from Crompton Corp.; [0592] Lactipol S.RTM., which is available
from Canamex Quimicos S.A de C.v; [0593] Magrabar PGO.RTM., which
is available from Magrabar Chemical Corp.; [0594] Mayco Base
BFC.RTM., which is available from Dover Chemical Corp.; [0595]
Methyl Linoleates, which is available from Hart Chemical Corp.;
[0596] Pationic 122A.RTM., which is available from RITA Corp.;
[0597] Pationic 138C.RTM., which is available from RITA Corp.;
[0598] Pationic CSL.RTM., which is available from RITA Corp.;
[0599] Pationic ISL.RTM., which is available from RITA Corp.;
[0600] Pationic SBL.RTM., which is available from RITA Corp.;
[0601] Pationic SSL.RTM., which is available from RITA Corp.;
[0602] Ritasol.RTM., which is available from RITA Corp.; [0603]
Tego Alkanol CS 20.RTM., which is available from Goldschmidt
Chemical Corp.; [0604] Tego Alkanol L23 P.RTM., which is available
from Goldschmidt Chemical Corp.; [0605] Tego Alkanol S2.RTM., which
is available from Goldschmidt Chemical Corp.; [0606] Tego Alkanol
S20 P.RTM., which is available from Goldschrhidt Chemical Corp.;
and [0607] Triemulsifier 600 MS.RTM., which is available from
Tri-Tex Co..RTM., Inc.; Glycerol Esters, including but not limited
to, [0608] Agro #9 Wint SBO.RTM., which is available from Lambent
Technologies Corp.; [0609] Ahcovel Base 700.RTM., which is
available from Uniqema; [0610] Aldo HMS FG.RTM., which is available
from Lonza Inc.; [0611] Aldo MLD.RTM., which is available from
Lonza Inc.; [0612] Aldo MLD FG.RTM., which is available from Lonza
Inc.; [0613] Aldo MO FG.RTM., which is available from Lonza Inc.;
[0614] Aldo MS.RTM., which is available from Lonza Inc.; [0615]
Aldo MS FG.RTM., which is available from Lonza Inc.; [0616] Aldo MS
LG FG.RTM., which is available from Lonza Inc.; [0617] Aldo
MSD.RTM., which is available from Lonza Inc.; [0618] Aldo MSD
FG.RTM., which is available from Lonza Inc.; [0619] Aldosperse O-20
FG.RTM., which is available from Lonza Inc.; [0620] Aldosperse
TS-20 FG.RTM., which is available from Lonza Inc.; [0621]
Aldosperse TS-40 FG.RTM., which is available from Lonza Inc.;
[0622] Arlacel 165.RTM., which is available from Uniqema; [0623]
Arlacel 186.RTM., which is available from Uniqema; [0624] Capmul
GMO.RTM., which is available from Abitec Corporation; [0625] Capmul
GMS.RTM., which is available from Abitec Corporation; [0626] Caprol
3GO.RTM., which is available from Abitec Corporation; [0627] Caprol
3GVS.RTM., which is available from Abitec Corporation; [0628]
Caprol 6G2S.RTM., which is available from Abitec Corporation;
[0629] Caprol 10G40.RTM., which is available from Abitec
Corporation; [0630] Caprol 10G100.RTM., which is available from
Abitec Corporation; [0631] Caprol ET.RTM., which is available from
Abitec Corporation; [0632] Caprol PGE860.RTM., which is available
from Abitec Corporation; [0633] Cerasynt 945.RTM., which is
available from International Specialty Products/IS; [0634] Cerasynt
GMS.RTM., which is available from International Specialty
Products/IS; [0635] Cerasynt Q.RTM., which is available from
International Specialty Products/IS; [0636] Cerasynt SD.RTM., which
is available from International Specialty Products/IS; [0637]
Cerasynt WM.RTM., which is available from International Specialty
Products/IS; [0638] Chemsperse 14.RTM., which is available from
Chemron Corp.; [0639] Cremophor GO-32.RTM., which is available from
BASF Corp.; [0640] Cremophor GS11.RTM., which is available from
BASF Corp.; [0641] Cremophor GS-32.RTM., which is available from
BASF Corp.; [0642] Cutina KD-16.RTM., which is available from
Cognis Canada Corp.; [0643] Dehymuls PGPH.RTM., which is available
from Cognis Corporation; [0644] Dermol DGDIS.RTM., which is
available from Alzo International, Inc.; [0645] Dermol DGMIS.RTM.,
which is available from Alzo International, Inc.; [0646] Dermol
G-76.RTM., which is available from Alzo International, Inc.; [0647]
Dermol G-7DI.RTM., which is available from Alzo International,
Inc.; [0648] Dermol NGDI.RTM., which is available from Alzo
International, Inc.; [0649] Dermolan GLH.RTM., which is available
from Alzo International, Inc.; [0650] Drewmulse GMO.RTM., which is
available from Stepan Company; [0651] Drewpol 3-5-M.RTM., which is
available from Stepan Company; [0652] Durlac 100 W.RTM., which is
available from Loders Croklaan U.S.A.; [0653] Dur-Lo.RTM., which is
available from Loders Croklaan U.S.A.; [0654] Dynasan 118.RTM.,
which is available from Sasol North America Inc.; [0655]
EC-25.RTM., which is available from Loders Croklaan U.S.A.; [0656]
EM 40.RTM., which is available from Keil Chemical; [0657] Emerest
2400.RTM., which is available from Cognis Corporation; [0658]
Emerest 2452.RTM., which is available from Cognis Corporation;
[0659] Empilan G-26.RTM., which is available from Huntsman LLC;
[0660] Genapol TSM.RTM., which is available from Clariant
Corporation; [0661] Hostacerin DGI.RTM., which is available from
Clariant Corporation; [0662] Hostacerin DGL.RTM., which is
available from Clariant Corporation; [0663] Hostacerin DGMS.RTM.,
which is available from Clariant Corporation; [0664] Hostacerin
DGSB.RTM., which is available from Clariant Corporation; [0665] Ice
No. 2.RTM., which is available from Loders Croklaan U.S.A.; lmwitor
742.RTM., which is available from Sasol North America Inc.; [0666]
Imwitor 780 K.RTM., which is available from Sasol North America
Inc.; [0667] Imwitor 960 Flakes.RTM., which is available from Sasol
North America Inc.; [0668] Isolan GI 34.RTM., which is available
from Goldschmidt Chemical Corp.; [0669] Isolan GO 33.RTM., which is
available from Goldschmidt Chemical Corp.; [0670] Kemester
1000.RTM., which is available from Crompton Corp.; [0671] Kemester
2000.RTM., which is available from Crompton; [0672] Kemester
2000.RTM., which is available from Crompton Corp.; [0673] Kemester
6000SE.RTM., which is available from Crompton Corp.; [0674]
Lamecreme DGE 18.RTM., which is available from Cognis Corporation;
[0675] Lexemul 515.RTM., which is available from Inolex Chemical
Co.; [0676] Lexemul 561.RTM., which is available from Inolex
Chemical Co.; [0677] Lexemul AR.RTM., which is available from
Inolex Chemical Co.; [0678] Lexemul AS.RTM., which is available
from Inolex Chemical Co.; [0679] Lexemul GDL.RTM., which is
available from Inolex Chemical Co.; [0680] Lexemul T.RTM., which is
available from Inolex Chemical Co.; [0681] Lipomulse 165.RTM.,
which is available from Lipo Chemicals, Inc.; [0682] Lumulse GML
K.RTM., which is available from Lambent Technologies Corp.; [0683]
Lumulse GMO K.RTM., which is available from Lambent Technologies
Corp.; [0684] Lumulse GMR K.RTM., which is available from Lambent
Technologies Corp.; [0685] Lumulse GMT K.RTM., which is available
from Lambent Technologies Corp.; [0686] Magrabar GMC.RTM., which is
available from Magrabar Chemical Corp.; [0687] Magrabar
GMO-CK.RTM., which is available from Magrabar Chemical Corp.;
[0688] Magrabar MDG-5050.RTM., which is available from Magrabar
Chemical Corp.; [0689] Magrabar PGO-315.RTM., which is available
from Magrabar Chemical Corp.; [0690] Magrabar PGO-1010.RTM., which
is available from Magrabar Chemical Corp.; [0691] Mazol 300K.RTM.,
which is available from BASF Corp.; [0692] Mazol GMO-K.RTM., which
is available from BASF Corp.; [0693] Mazol GMS-K.RTM., which is
available from BASF Corp.; [0694] Mazol PG031-K.RTM., which is
available from BASF Corp.; [0695] Miglyol 812.RTM., which is
available from Sasol North America Inc.; [0696] Norfox 165C.RTM.,
which is available from Norman, Fox & Co.; [0697] Schercemol
GMIS.RTM., which is available from Noveons, Inc.; [0698]
Tegin.RTM., which is available from Goldschmidt Chemical Corp.;
[0699] Tegin 4100 Pellets.RTM., which is available from Goldschmidt
Chemical Corp.; [0700] Tegin M Pellets.RTM., which is available
from Goldschmidt Chemical Corp.; [0701] Tegin OV.RTM., which is
available from Goldschmidt Chemical Corp.; [0702] Teginacid H.RTM.,
which is available from Goldschmidt Chemical Corp.; [0703] Tego
Cosmo P813.RTM., which is available from Goldschmidt Chemical
Corp.; [0704] Wickenol 535.RTM., which is available from Alzo
International, Inc.; [0705] Witconol 14.RTM., which is available
from Akzo Nobel Surface Chemistry LLC; [0706] Witconol 14.RTM.,
which is available from Crompton Corp.; [0707] Witconol 14F.RTM.,
which is available from Crompton Corp.; [0708] Witconol 18L.RTM.,
which is available from Crompton Corp.; [0709] Witconol GOT.RTM.,
which is available from Crompton Corp.; [0710] Witconol MST.RTM.,
which is available from Crompton Corp.; and [0711] Witconol
RHT.RTM., which is available from Crompton Corp.; Glycol Esters,
including but not limited to, [0712] Alkamuls 600 DO.RTM., which is
available from Rhodia, Inc.; [0713] Alkamuls SEG.RTM., which is
available from Rhodia, Inc.; [0714] Atlas EM-2.RTM., which is
available from Atlas Refinery Inc.; [0715] Cerasynt IP.RTM., which
is available from International Specialty Products/IS; [0716]
Cerasynt M.RTM., which is available from International Specialty
Products/IS; [0717] Cerasynt MN.RTM., which is available from
International Specialty Products/IS;
[0718] Cerasynt PA.RTM., which is available from International
Specialty Products/IS; [0719] Chemsperse EGDS.RTM., which is
available from Chemron Corp.; [0720] Chemsperse EGMS.RTM., which is
available from Chemron Corp.; [0721] Colonial Monolaurin.RTM.,
which is available from Colonial Chemical Co.; [0722] DeMuls
SGE-95.RTM., which is available from DeForest Enterprises, Inc.;
[0723] Eccoterge 200.RTM., which is available from Eastern Color
& Chemical Co.; [0724] Emerest 2380.RTM., which is available
from Cognis Corporation; [0725] Ethox 2610.RTM., which is available
from Ethox Chemicals, LLC; [0726] Ethox DO-9.RTM., which is
available from Ethox Chemicals, LLC; [0727] Ethox DO-14.RTM., which
is available from Ethox Chemicals, LLC; [0728] Ethox SO-9.RTM.,
which is available from Ethox Chemicals, LLC; [0729] Fizul
MD-318.RTM., which is available from Finetex Inc.; [0730] Genapol
EGDS-VHP.RTM., which is available from Clariant Corporation; [0731]
Genapol TS Powder.RTM., which is available from Clariant
Corporation; [0732] Hostacerin WO.RTM., which is available from
Clariant Corporation; [0733] Inversol 140.RTM., which is available
from Keil Chemical; [0734] Kemester 104.RTM., which is available
from Crompton Corp.; [0735] Kemester 205.RTM., which is available
from Crompton Corp.; [0736] Kemester 226.RTM., which is available
from Crompton Corp.; [0737] Kemester 5221SE.RTM., which is
available from Crompton Corp.; [0738] Kemester EGDS.RTM., which is
available from Crompton Corp.; [0739] Lexemul EGDS.RTM., which is
available from Inolex Chemical Co.; [0740] Lexemul EGMS.RTM., which
is available from Inolex Chemical Co.; [0741] Lexemul P.RTM., which
is available from Inolex Chemical Co.; [0742] Lipo DGLS.RTM.,
Self-Emulsifying.RTM., which is available from Lipo Chemicals,
Inc.; [0743] Lipo EGDS.RTM., which is available from Lipo
Chemicals, Inc.; [0744] Lipo PGMS.RTM., which is available from
Lipo Chemicals, Inc.; [0745] Liposorb S-4.RTM., which is available
from Lipo Chemicals, Inc.; [0746] Liposorb TO-20.RTM., which is
available from Lipo Chemicals, Inc.; [0747] Lumulse PGO.RTM., which
is available from Lambent Technologies Corp.; [0748] Mackester
EGDS.RTM., which is available from The McIntyre Group; [0749]
Mackester EGMS.RTM., which is available from The McIntyre Group;
[0750] Mackester GSTP.RTM., which is available from The McIntyre
Group; [0751] Mackester Series.RTM., which is available from The
McIntyre Group; [0752] Magrabar PDG-50.RTM., which is available
from Magrabar Chemical Corp.; [0753] Mapeg 6000 DS.RTM., which is
available from BASF Corp.; [0754] Marlowet 4702.RTM., which is
available from Sasol North America Inc.; [0755] Monalube 305.RTM.,
which is available from Uniqema; [0756] Monalube 310.RTM., which is
available from Uniqema; [0757] Monalube 315.RTM., which is
available from Uniqema; [0758] Monalube 320.RTM., which is
available from Uniqema; [0759] Monalube 325.RTM., which is
available from Uniqema; [0760] Monalube 330.RTM., which is
available from Uniqema; [0761] Naturechem PGHS.RTM., which is
available from CasChem.RTM., Inc.; [0762] Polycastorol
PLO-840.RTM., which is available from Magrabar Chemical Corp.;
[0763] Polytex 10M.RTM., which is available from Lipo Chemicals,
Inc.; [0764] Ritasynt IP.RTM., which is available from RITA Corp.;
[0765] Ross Chem PEG 600 DT.RTM., which is available from Lubrizol
Foam Control Additives; [0766] Schercemol PGMS.RTM., which is
available from Noveon.RTM., Inc.; [0767] Sponto H-44C.RTM., which
is available from Crompton Corp.; [0768] Tegin G.RTM., which is
available from Goldschmidt Chemical Corp.; [0769] Witbreak
DGE-182.RTM., which is available from Akzo Nobel Surface Chemistry
LLC; [0770] Witbreak DGE-182.RTM., which is-available from Crompton
Corp.; [0771] Witbreak DRA-21.RTM., which is available from Akzo
Nobel Surface Chemistry LLC; [0772] Witbreak DRA-21.RTM., which is
available from Crompton Corp.; [0773] Witbreak DRA-50.RTM., which
is available from Akzo Nobel Surface Chemistry LLC; [0774] Witbreak
DRA-50.RTM., which is available from Crompton Corp.; [0775]
Witconol F26-46.RTM., which is available from Crompton Corp.;
[0776] Witconol H-32.RTM., which is available from Akzo Nobel
Surface Chemistry LLC; [0777] Witconol H-33.RTM., which is
available from Akzo Nobel Surface Chemistry LLC; [0778] Witconol
H-35A.RTM., which is available from Crompton Corp.; and [0779]
Witconol RHP.RTM., which is available from Crompton Corp.;
Lanolin-based Derivatives, including but not limited to, [0780]
Amerchol CAB.RTM., which is available from Amerchol Corp.; [0781]
Amerchol L-101.RTM., which is available from Amerchol Corp.; [0782]
Amerlate LFA-LO.RTM., which is available from Amerchol Corp.;
[0783] Amerlate P.RTM., which is available from Amerchol Corp.;
[0784] Barre Common Degras.RTM., which is available from RITA
Corp.; [0785] Cholesterol NF.RTM., which is available from Croda
Inc.; [0786] Crodalan AWS.RTM., which is available from Croda Inc.;
[0787] Crodalan LA.RTM., which is available from Croda Inc.; [0788]
Emery 1650.RTM., which is available from Cognis Canada Corp.;
[0789] Emery 1650.RTM., which is available from Cognis Corporation;
[0790] Emery 1740.RTM., which is available from Cognis Canada
Corp.; [0791] Emery 1740.RTM., which is available from Cognis
Corporation; [0792] Forlan 500.RTM., which is available from RITA
Corp.; [0793] Forlan L.RTM., which is available from RITA Corp.;
[0794] Laneto 50.RTM., which is available from RITA Corp.; [0795]
Laneto 100.RTM., which is available from RITA Corp.; [0796] Laneto
AWS.RTM., which is available from RITA Corp.; [0797] Lanfrax
1776.RTM., which is available from Cognis Canada Corp.; [0798]
Lanfrax 1776.RTM., which is available from Cognis Corporation;
[0799] Lanogel 21.RTM., which is available from Amerchol Corp.;
[0800] Lipolan.RTM., which is available from Lipo Chemicals, Inc.;
[0801] Lipolan 31.RTM., which is available from Lipo Chemicals,
Inc.; [0802] OHlan.RTM., which is available from Amerchol Corp.;
[0803] Polychol 5.RTM., which is available from Croda Inc.; [0804]
Polychol 15.RTM., which is available from Croda Inc.; [0805]
Ritacetyl.RTM., which is available from RITA Corp.; [0806]
Ritachol.RTM., which is available from RITA Corp.; [0807]
Ritahydrox.RTM., which is available from RITA Corp.; [0808]
Ritalafa.RTM., which is available from RITA Corp.; [0809]
Ritalan.RTM., which is available from RITA Corp.; [0810] Ritalan
AWS.RTM., which is available from RITA Corp.; [0811] Ritalan
C.RTM., which is available from RITA Corp.; [0812] Ritawax.RTM.,
which is available from RITA Corp.; [0813] Ritawax AEO.RTM., which
is available from RITA Corp.; [0814] Ritawax ALA.RTM., which is
available from RITA Corp.; [0815] Solan/Solan 50/Super Solan.RTM.,
which is available from Croda Inc.; [0816] Super
Hartolan/Hartolan.RTM., which is available from Croda Inc.; [0817]
Supersat AWS-4.RTM., which is available from RITA Corp.; and [0818]
Supersat AWS-24.RTM., which is available from RITA Corp.; Lecithin
and Lecithin Derivatives, including but not limited to, [0819]
Alcolec.RTM., which is available from American Lecithin Co.; [0820]
Lecithin.RTM., which is available from Archer Daniels Midland
Company; [0821] Lexin K.RTM., which is available from American
Lecithin Co.; and [0822] Natipide.RTM., which is available from
American Lecithin Co.; Lignin and Lignin Derivatives, including but
not limited to, [0823] Diwatex XP 9.RTM., which is available from
Borregaard Lignotech USA Inc.; [0824] Dynasperse LCD.RTM., which is
available from Borregaard Lignotech USA Inc.; [0825] Indulin
SAL.RTM., which is available from MeadWestvaco Corp.; [0826]
Indulin W-1.RTM., which is available from MeadWestvaco Corp.;
[0827] Indulin W-5.RTM., which is available from MeadWestvaco
Corp.; [0828] Lignosol FTA.RTM., which is available from Borregaard
Lignotech USA Inc.; [0829] Lignosol SFX-65.RTM., which is available
from Borregaard Lignotech USA Inc.; [0830] Marasperse 52 CP.RTM.,
which is available from Borregaard Lignotech USA Inc.; [0831]
Marasperse AG.RTM., which is available from Borregaard Lignotech
USA Inc.; [0832] Marasperse CBOS-4.RTM., which is available from
Borregaard Lignotech USA Inc.; and [0833] Ufoxane 2.RTM., which is
available from Borregaard Lignotech USA Inc.; Methyl Esters,
including but not limited to, [0834] E.B. Cleaner AK.RTM., which is
available from Eastern Color & Chemical Co.; [0835] Oleocal
ME-70.RTM., which is available from Lambent Technologies Corp.;
[0836] Oleocal ME-92.RTM., which is available from Lambent
Technologies Corp.; [0837] Oleocal ME-112.RTM., which is available
from Lambent Technologies Corp.; and [0838] Oleocal ME-130.RTM.,
which is available from Lambent Technologies Corp.; Monoglycerides
and Derivatives, including but not limited to, [0839] Dynacet
211.RTM., which is available from Sasol North America Inc.; [0840]
Hetsorb S-20.RTM., which is available from Global-Seven, Inc.;
[0841] Imwitor 191.RTM., which is available from Sasol North
America Inc.; [0842] Imwitor 370.RTM., which is available from
Sasol North America Inc.; [0843] Imwitor 375.RTM., which is
available from Sasol North America Inc.; [0844] Imwitor 900.RTM.,
which is available from Sasol North America Inc.; [0845] Imwitor
945.RTM., which is available from Sasol North America Inc.; [0846]
Imwitor 2020.RTM., which is available from Sasol North America
Inc.; [0847] Kemester 5500.RTM., which is available from Crompton
Corp.; [0848] Kemester 6000.RTM., which is available from Crompton
Corp.; [0849] Magrabar GMC.RTM., which is available from Magrabar
Chemical Corp.; [0850] Magrabar GMO-CK.RTM., which is available
from Magrabar Chemical Corp.; [0851] Magrabar GPC-10.RTM., which is
available from Magrabar Chemical Corp.; [0852] Magrabar
MDG-5050.RTM., which is available from Magrabar Chemical Corp.;
[0853] Monalube 335.RTM., which is available from Uniqema; [0854]
Monoglycerides Glyceryl Monestearate Archer Daniels Midland
Company; [0855] Rita GMS.RTM., which is available from RITA Corp.;
[0856] Ritamulse SCG.RTM., which is available from RITA Corp.;
[0857] Softigen 701.RTM., which is available from Sasol North
America Inc.; and [0858] Tally 100 Plus.RTM., which is available
from Loders Croklaan U.S.A.; Polyethylene Glycols, including but
not limited to, [0859] Emulgade PL 68/50.RTM., which is available
from Cognis Corporation; [0860] Lumulse PEG.RTM., which is
available from Lambent Technologies Corp.; [0861] Rhodasurf
PEG-400.RTM., which is available from Rhodia, Inc.; [0862]
Rhodasurf PEG-600.RTM., which is available from Rhodia, Inc.; and
[0863] Witconol PEG-400.RTM., which is available from Akzo Nobel
Surface Chemistry LLC; Polymeric Surfactants, including but not
limited to, [0864] Acritamer PNC-EG.RTM., which is available from
RITA Corp.; [0865] Ag-Rho DEP-775.RTM., which is available from
Rhodia, Inc.; [0866] APG 325N Glycoside.RTM., which is available
from Cognis Corporation; [0867] Aristoflex AVC.RTM., which is
available from Clariant Corporation; [0868] Aristoflex HMB.RTM.,
which is available from Clariant Corporation; [0869] Burco
NPS-225.RTM., which is available from Burlington Chemical Co..RTM.,
Inc.; [0870] Burco NPS-816.RTM., which is available from Burlington
Chemical Co..RTM., Inc.; [0871] Chemccinate 5603.RTM., which is
available from Chemron Corp.; [0872] Cosmedia Guar C-261N.RTM.,
which is available from Cognis Corporation; [0873] Gantrez
S-95.RTM., which is available from International Specialty
Products/IS; [0874] Glucopon 220 UP.RTM., which is available from
Cognis Corporation; [0875] Glucopon 225 DK.RTM., which is available
from Cognis Corporation; [0876] Glucopon 425 N.RTM., which is
available from Cognis Corporation; [0877] Glucopon 600 UP.RTM.,
which is available from Cognis Corporation; [0878] Glucopon 625
UP.RTM., which is available from Cognis Corporation; [0879] Pemulen
1621.RTM., which is available from Noveon.RTM., Inc.; [0880]
Pemulen 1622.RTM., which is available from Noveon.RTM., Inc.;
[0881] Pemulen TR-1.RTM., which is available from Noveon.RTM.,Inc.;
[0882] Pemulen TR-2.RTM., which is.available from Noveon.RTM.,Inc.;
[0883] Plantacare 818.RTM., which is available from Cognis
Corporation; [0884] Plantapon LGC Sorb.RTM., which is available
from Cognis Corporation; [0885] Plantaren 1200N.RTM., which is
available from Cognis Corporation; [0886] Plantaren 2000N.RTM.,
which is available from Cognis Corporation; [0887] Viscolam AT
64.RTM., which is available from RITA Corp.; [0888] Viscolam AT
64P.RTM., which is available from RITA Corp.; [0889] Viscolam AT
100.RTM., which is available from RITA Corp.; [0890] Viscolam MAC
7.RTM., which is available from RITA Corp.; [0891] Viscolam SMC
20.RTM., which is available from RITA Corp.; [0892] Witbreak
RTC-323.RTM., which is available from Crompton Corp.; and [0893]
WSI 3700.RTM., which is available from Jacam Chemicals, L.L.C.;
Propoxylated & Ethoxylated Fatty Acids, Alcohols, or Alkyl
Phenols, including but not limited to, [0894] Antarox AA-60.RTM.,
which is available from Rhodia, Inc.; [0895] Antarox LF-224.RTM.,
which is available from Rhodia, Inc.; [0896] Burcomul DFE-45.RTM.,
which is available from Burlington Chemical Co..RTM., Inc.; [0897]
Burcoterge LFE-1000.RTM., which is available from Burlington
Chemical Co..RTM., Inc.; [0898] Chemal LF-25B.RTM., which is
available from Chemax Performance Solutions; [0899] Chemal
LF-40B.RTM., which is available from Chemax Performance Solutions;
[0900] Dehypon LS-36.RTM., which is available from Cognis Canada
Corp.; [0901] Dehypon LS-36.RTM., which is available from Cognis
Corporation; [0902] Dehypon LS-54.RTM., which is available from
Cognis Canada Corp.; [0903] Dehypon LS-54.RTM., which is available
from Cognis Corporation; [0904] Delonic 100 VLF.RTM., which is
available from DeForest Enterprises, Inc.; [0905] Delonic LF-60
MOD.RTM., which is available from DeForest Enterprises, Inc.;
[0906] Empiderm B.RTM., which is available from Huntsman LLC;
[0907] Ethylan 1206.RTM., which is available from Akzo Nobel
Surface Chemistry LLC; [0908] Ethylan NS-500K.RTM., which is
available from Akzo Nobel Surface Chemistry LLC; [0909] Ethylan
NS-500LQ.RTM., which is available from Akzo Nobel Surface Chemistry
LLC; [0910] Genapol 1392.RTM., which is available from Clariant
Corporation; [0911] Genapol 2317.RTM., which is available from
Clariant Corporation; [0912] Genapol 26EP710.RTM., which is
available from Clariant Corporation; [0913] Genapol EP 1022.RTM.,
which is available from Clariant Corporation; [0914] Genapol EP
1024.RTM., which is available from Clariant Corporation;
[0915] Genapol EP 6068.RTM., which is available from Clariant
Corporation; [0916] Genapol NP915.RTM., which is available from
Clariant Corporation; [0917] Kieralon MFB.RTM., which is available
from BASF Corp.; [0918] Lumisolve CSA-80 V.RTM., which is available
from Lambent Technologies Corp.; [0919] Marlowet 5001.RTM., which
is available from Sasol North America Inc.; [0920] Marlox FK
64.RTM., which is available from Sasol North America Inc.; [0921]
Marlox MO 124.RTM., which is available from Sasol North America
Inc.; [0922] Marlox S 58.RTM., which is available from Sasol North
America Inc.; [0923] Nonatell 1003.RTM., which is available from
Tomah Products.RTM., Inc.; [0924] Nonatell 1038.RTM., which is
available from Tomah Products.RTM., Inc.; [0925] Nonatell
1052.RTM., which is available from Tomah Products.RTM., Inc.;
[0926] Nonatell 1061.RTM., which is available from Tomah
Products.RTM., Inc.; [0927] Nonatell 1075.RTM., which is available
from Tomah Products.RTM., Inc.; [0928] Nonatell 1088.RTM., which is
available from Tomah Products.RTM., Inc.; [0929] Nonatell
1123.RTM., which is available from Tomah Products.RTM., Inc.;
[0930] Nonatell 1153.RTM., which is available from Tomah
Products.RTM., Inc.; [0931] Nonatell 1161.RTM., which is available
from Tomah Products.RTM., Inc.; [0932] Nonatell 1172.RTM., which is
available from Tomah Products.RTM., Inc.; [0933] Nonatell
1181.RTM., which is available from Tomah Products.RTM., Inc.;
[0934] Norfox 36.RTM., which is available from Norman, Fox &
Co.; [0935] Procetyl AWS.RTM., which is available from Croda Inc.;
[0936] Sandoxylate SX 412.RTM. Liquid, which is available from
Clariant Corporation; [0937] Sandoxylate SX 418.RTM., which is
available from Clariant Corporation; [0938] Surfonic JL-80X.RTM.,
which is available from Huntsman LLC; [0939] Surfonic
JL-80X-B1.RTM., which is available from Huntsman LLC; [0940]
Surfonic L4-29X.RTM., which is available from Huntsman LLC; [0941]
Surfonic LF.RTM., which is available from Huntsman LLC; [0942]
T-Det A826.RTM., which is available from Harcros Chemicals Inc.;
[0943] T-Det LF-416.RTM., which is available from Harcros Chemicals
Inc.; [0944] Tergitol Min-Foam 1X.RTM., which is available from Dow
Chemical Company; [0945] Tergitol Min-Foam 2X.RTM., which is
available from Dow Chemical Company; [0946] Triton CF-21.RTM.,
which is available from Dow Chemical Company; [0947] Triton
CF-76.RTM., which is available from Dow Chemical Company; [0948]
Triton XL-80N.RTM., which is available from Dow Chemical Company;
[0949] Witconol NS-98.RTM., which is available from Akzo Nobel
Surface Chemistry LLC; [0950] Witconol NS-108LQ.RTM., which is
available from Akzo Nobel Surface Chemistry LLC; [0951] Witconol
NS-145.RTM., which is available from Akzo Nobel Surface Chemistry
LLC; and [0952] Witconol NS-179.RTM., which is available from Akzo
Nobel Surface Chemistry LLC; Protein-based Surfactants, including
but not limited to, [0953] AminoFoam W.RTM., which is available
from Croda Inc.; [0954] Amiter LGOD-2.RTM., which is available from
Ajinomoto USA, Inc.; [0955] Amiter LGS-2.RTM., which is available
from Ajinomoto USA, Inc.; [0956] Amiter LGS-5.RTM., which is
available from Ajinomoto USA, Inc.; [0957] Lamepon S.RTM., which is
available from Cognis Canada Corp.; [0958] Lamepon S.RTM., which is
available from Cognis Corporation; [0959] Maypon 4C.RTM., which is
available from Inolex Chemical Co.; [0960] May-Tein C.RTM., which
is available from Maybrook, Inc.; [0961] May-Tein CT.RTM., which is
available from Maybrook, Inc.; [0962] May-Tein KTS.RTM., which is
available from Maybrook, Inc.; [0963] May-Tein SY.RTM., which is
available from Maybrook, Inc.; [0964] Plantapon S.RTM., which is
available from Cognis Corporation; [0965] Proteol APL.RTM., which
is available from Seppic Inc.; [0966] Proteol OAT.RTM., which is
available from Seppic Inc.; [0967] Pyroter CPI-40.RTM., which is
available from Ajinomoto USA, Inc.; [0968] Pyroter GPI-25.RTM.,
which is available from Ajinomoto USA, Inc.; [0969] Supro-Tein
S.RTM., which is available from Maybrook, Inc.; and [0970]
Supro-Tein V.RTM., which is available from Maybrook, Inc.;
Sarcosine Derivatives, including but not limited to, [0971]
Crodasinic LS-30.RTM., which is available from Croda Inc.; [0972]
Vanseal CS.RTM., which is available from R. T. Vanderbilt Co. Inc.;
[0973] Vanseal LS.RTM., which is available from R. T. Vanderbilt
Co. Inc.; [0974] Vanseal MS.RTM., which is available from R. T.
Vanderbilt Co. Inc.; [0975] Vanseal NACS-30.RTM., which is
available from R. T. Vanderbilt Co. Inc.; [0976] Vanseal
NALS-95.RTM., which is available from R. T. Vanderbilt Co. Inc.;
and [0977] Vanseal OS.RTM., which is available from R. T.
Vanderbilt Co. Inc.; Silicone-based Surfactants, including but not
limited to, [0978] Abil-B-9950.RTM., which is available from
Goldschmidt Chemical Corp.; [0979] Abil Care 85.RTM., which is
available from Goldschmidt Chemical Corp.; [0980] Abil EM 90.RTM.,
which is available from Goldschmidt Chemical Corp.; [0981] Abil EM
97.RTM., which is available from Goldschmidt Chemical Corp.; [0982]
Abil WE-09.RTM., which is available from Goldschmidt Chemical
Corp.; [0983] Dow Corning 1248 Fluid.RTM., which is available from
Dow Corning Corp.; [0984] Dow Corning 3225C.RTM. Formulation Aid,
which is available from Dow Corning Corp.; [0985] Dow Corning
5200.RTM. Formulation Aid, which is available from Dow Corning
Corp.; [0986] Dow Corning Q4-3667.RTM. Fluid, which is available
from Dow Corning Corp.; [0987] Monasil PCA.RTM., which is available
from Uniqema; [0988] Monasil PDM.RTM., which is available from
Uniqema; [0989] Monasil PLN.RTM., which is available from Uniqema;
[0990] Polyderm PPI-SI-WS.RTM., which is available from Alzo
International, Inc.; [0991] Troysol 380W.RTM., which is available
from Troy Corporation; and [0992] Troysol S366.RTM., which is
available from Troy Corporation; Sorbitan Derivatives, including
but not limited to, [0993] Alkamuls SML.RTM., which is available
from Rhodia, Inc.; [0994] Alkamuls SMO.RTM., which is available
from Rhodia, Inc.; [0995] Alkamuls STO.RTM., which is available
from Rhodia, Inc.; [0996] Arlacel 20.RTM., which is available from
Uniqema; [0997] Arlacel 40.RTM., which is available from Uniqema;
[0998] Arlacel 60.RTM., which is available from Uniqema; [0999]
Arlacel 80.RTM., which is available from Uniqema; [1000] Arlacel
C.RTM., which is available from Uniqema; [1001] Armul 21.RTM.,
which is available from Crompton Corp.; [1002] Atlox 80.RTM., which
is available from Uniqema; [1003] Atlox 847.RTM., which is
available from Uniqema; [1004] Atlox 1045A.RTM., which is available
from Uniqema; [1005] Canarcel 20.RTM., which is available from
Canamex Quimicos S.A de C.v; [1006] Canarcel 60.RTM., which is
available from Canamex Quimicos S.A de C.v; [1007] Canarcel
80.RTM., which is available from Canamex Quimicos S.A de C.v;
[1008] Canarcel TW 20.RTM., which is available from Canamex
Quimicos S.A de C.v; [1009] Canarcel TW 60.RTM., which is available
from Canamex Quimicos S.A de C.v; [1010] Canarcel TW 80.RTM., which
is available from Canamex Quimicos S.A de C.v; [1011] Coladet
BSB-P.RTM., which is available from Colonial Chemical Co.; [1012]
Customulse O-20.RTM., which is available from Custom Ingredients,
Inc.; [1013] Dehymuls E.RTM., which is available from Cognis Canada
Corp.; [1014] DeSotan SMO.RTM., which is available from Crompton
Corp.; [1015] DeSotan SMO-20.RTM., which is available from Crompton
Corp.; [1016] DeSotan SMT.RTM., which is available from Crompton
Corp.; [1017] DeSotan SMT-20.RTM., which is available from Crompton
Corp.; [1018] Durfax 60.RTM., which is available from Loders
Croklaan U.S.A.; [1019] Durfax 65.RTM., which is available from
Loders Croklaan U.S.A.; [1020] Durfax 80.RTM., which is available
from Loders Croklaan U.S.A.; [1021] Durtan 60.RTM., which is
available from Loders Croklaan U.S.A.; [1022] Durtan 65.RTM., which
is available from Loders Croklaan U.S.A.; [1023] Liposorb L.RTM.,
which is available from Lipo Chemicals, Inc.; [1024] Liposorb
L-10.RTM., which is available from Lipo Chemicals, Inc.; [1025]
Liposorb L-20.RTM., which is available from Lipo Chemicals, Inc.;
[1026] Liposorb O.RTM., which is available from Lipo Chemicals,
Inc.; [1027] Liposorb O-20.RTM., which is available from Lipo
Chemicals, Inc.; [1028] Liposorb P.RTM., which is available from
Lipo Chemicals, Inc.; [1029] Liposorb P-20.RTM., which is available
from Lipo Chemicals, Inc.; [1030] Liposorb S.RTM., which is
available from Lipo Chemicals, Inc.; [1031] Liposorb S-2.RTM.,
which is available from Lipo Chemicals, Inc.; [1032] Liposorb
SQO.RTM., which is available from Lipo Chemicals, Inc.; [1033]
Liposorb TO.RTM., which is available from Lipo Chemicals, Inc.;
[1034] Liposorb TS.RTM., which is available from Lipo Chemicals,
Inc.; [1035] Liposorb TS-20.RTM., which is available from Lipo
Chemicals, Inc.; [1036] Lumisorb PS.RTM., which is available from
Lambent Technologies Corp.; [1037] Lumisorb SMO (T).RTM., which is
available from Lambent Technologies Corp.; [1038] Lumisorb SMS
K.RTM., which is available from Lambent Technologies Corp.; [1039]
Lumisorb SSO.RTM., which is available from Lambent Technologies
Corp.; [1040] Lumisorb STS K.RTM., which is available from Lambent
Technologies Corp.; [1041] Lumisorb STT.RTM., which is available
from Lambent Technologies Corp.; [1042] Magrabar SMO.RTM., which is
available from Magrabar Chemical Corp.; [1043] Magrabar
SMO-VEG.RTM., which is available from Magrabar Chemical Corp.;
[1044] Magrabar SMT.RTM., which is available from Magrabar Chemical
Corp.; [1045] Magrabar STO.RTM., which is available from Magrabar
Chemical Corp.; [1046] Miracare BC-27.RTM., which is available from
Rhodia, Inc.; [1047] Ritabate 20.RTM., which is available from RITA
Corp.; [1048] Ritabate 40.RTM., which is available from RITA Corp.;
[1049] Ritabate 60.RTM., which is available from RITA Corp.; [1050]
Ritabate 80.RTM., which is available from RITA Corp.; [1051]
T-Maz.RTM., which is available from BASF Corp.; [1052] Tego
SML.RTM., which is available from Goldschmidt Chemical Corp.;
[1053] Tego SML 20.RTM., which is available from Goldschmidt
Chemical Corp.; [1054] Tego SMO 80 V.RTM., which is available from
Goldschmidt Chemical Corp.; [1055] Tego SMO V.RTM., which is
available from Goldschmidt Chemical Corp.; [1056] Tego SMS.RTM.,
which is available from Goldschmidt Chemical Corp.; [1057] Tego STO
V.RTM., which is available from Goldschmidt Chemical Corp.; [1058]
Tween 21.RTM., which is available from Uniqema; [1059] Tween
40.RTM., which is available from Uniqema; [1060] Tween 60.RTM.,
which is available from Uniqema; [1061] Tween 60 K.RTM., which is
available from Uniqema; [1062] Tween 61.RTM., which is available
from Uniqema; [1063] Tween 65.RTM., which is available from
Uniqema; [1064] Tween 80.RTM., which is available from Uniqema;
[1065] Tween 80 K.RTM., which is available from Uniqema; [1066]
Tween 81.RTM., which is available from Uniqema; and [1067] Tween
85.RTM., which is available from Uniqema; Sucrose and Glucose
Esters and Derivatives, including but not limited to, [1068] DeSulf
GOS-P-60WCG.RTM., which is available from DeForest Enterprises,
Inc.; [1069] Glucam E-20 Distearate.RTM., which is available from
Amerchol Corp.; [1070] Glucamate DOE-120.RTM., which is available
from Amerchol Corp.; [1071] Glucamate SSE-20.RTM., which is
available from Amerchol Corp.; [1072] Glucate DO.RTM., which is
available from Amerchol Corp.; [1073] Glucate SS.RTM., which is
available from Amerchol Corp.; [1074] Glucopon 425 UP.RTM., which
is available from Cognis Corporation; [1075] Isolan IS.RTM., which
is available from Goldschmidt Chemical Corp.; [1076] Mazon 40.RTM.,
which is available from BASF Corp.; [1077] Montanov 82.RTM., which
is available from Seppic Inc.; [1078] Montanov 202.RTM., which is
available from Seppic Inc.; [1079] Montanov S.RTM., which is
available from Seppic Inc.; [1080] Rheozan.RTM., which is available
from Rhodia, Inc.; [1081] Simulsol AS 48.RTM., which is available
from Seppic Inc.; [1082] Simulsol SL 4.RTM., which is available
from Seppic Inc.; [1083] Simulsol SL 10.RTM., which is available
from Seppic Inc.; [1084] Simulsol SL 11W.RTM., which is available
from Seppic Inc.; [1085] Simulsol SL 55.RTM., which is available
from Seppic Inc.; [1086] Suga Nate 100 and 160.RTM., which is
available from Colonial Chemical Co.; [1087] Tego Care 450.RTM.,
which is available from Goldschmidt Chemical Corp.; [1088] Tego
Care CG 90.RTM., which is available from Goldschmidt Chemical
Corp.; [1089] Tego Care PS.RTM., which is available from
Goldschmidt Chemical Corp.; [1090] Tegosoft PSE 141 G.RTM., which
is available from Goldschmidt Chemical Corp.; [1091] Tegotens G
826.RTM., which is available from Goldschmidt Chemical Corp.;
[1092] Triton BG-10 (700%).RTM., which is available from Dow
Chemical Company; [1093] Triton CG-110 (60%).RTM., which is
available from Dow Chemical Company; and [1094] Wickenol 545.RTM.,
which is available from Alzo International, Inc. Pluronic from BASF
is another useful type of surfactant.
[1095] Another embodiment comprises from about 0.001% to about 0.1%
cyclosporin A, castor oil, and a sorbitan ester.
[1096] Another embodiment comprises from about 0.001% to about 0.1%
cyclosporin A, castor oil, and Polysorbate 20.
[1097] Another embodiment comprises from about 0.001% to about 0.1%
cyclosporin A, castor oil, and Polysorbate 40.
[1098] Another embodiment comprises from about 0.001% to about 0.1%
cyclosporin A, castor oil, and Polysorbate 60.
[1099] Another embodiment comprises from about 0.001% to about 0.1%
cyclosporin A, castor oil, and Polysorbate 80.
[1100] Another embodiment comprises from about 0.001% to about 0.1%
cyclosporin A, castor oil, and a stearate.
[1101] Another embodiment comprises from about 0.001% to about 0.1%
cyclosporin A, castor oil, and glyceryl stearate.
[1102] Another embodiment comprises from about 0.001% to about 0.1%
cyclosporin A, castor oil, and isopropyl stearate.
[1103] Another embodiment comprises from about 0.001% to about 0.1%
cyclosporin A, castor oil, and polyoxyl stearate.
[1104] Another embodiment comprises from about 0.001% to about 0.1%
cyclosporin A, castor oil, and propylene glycol stearate.
[1105] Another embodiment comprises from about 0.001% to about 0.1%
cyclosporin A, castor oil, and sucrose stearate.
[1106] Another embodiment comprises from about 0.001% to about 0.1%
cyclosporin A, castor oil, and polyethylene glycol.
[1107] Another embodiment comprises from about 0.001% to about 0.1%
cyclosporin A, castor oil, and polyethylene oxide.
[1108] Another embodiment comprises from about 0.001% to about 0.1%
cyclosporin A, castor oil, and polypropylene oxide.
[1109] Another embodiment comprises from about 0.001% to about 0.1%
cyclosporin A, castor oil, and a polyethylene oxide-polypropylene
oxide copolymer.
[1110] Another embodiment comprises from about 0.001% to about 0.1%
cyclosporin A, castor oil, and an alcohol ethoxylate.
[1111] Another embodiment comprises from about 0.001% to about 0.1%
cyclosporin A, castor oil, and an alkylphenol ethoxylate.
[1112] Another embodiment comprises from about 0.001% to about 0.1%
cyclosporin A, castor oil, and an alkyl glycoside.
[1113] Another embodiment comprises from about 0.001% to about 0.1%
cyclosporin A, castor oil, and alkyl polyglycoside.
[1114] Another embodiment comprises from about 0.001% to about 0.1%
cyclosporin A, castor oil, and a fatty alcohol.
[1115] Another embodiment comprises from about 0.001% to about 0.1%
cyclosporin A, castor oil, and hydroxypropylmethyl cellulose.
[1116] Another embodiment comprises from about 0.001% to about 0.1%
cyclosporin A, castor oil, and carboxymethyl cellulose.
[1117] Another embodiment comprises from about 0.001% to about 0.1%
cyclosporin A, castor oil, and a polyacrylic acid.
[1118] Another embodiment comprises from about 0.001% to about 0.1%
cyclosporin A, castor oil, and a Carbomer.
[1119] Another embodiment comprises from about 0.001% to about 0.1%
cyclosporin A, castor oil, and a phosphalipid.
[1120] Another embodiment comprises from about 0.001% to about 0.1%
cyclosporin A, castor oil, and phosphatidyl chloline.
[1121] Another embodiment comprises from about 0.001% to about 0.1%
cyclosporin A, castor oil, and phosphatidyl serine.
[1122] Another embodiment comprises from about 0.005% to about
0.05% cyclosporin A, castor oil, and a sorbitan ester.
[1123] Another embodiment comprises from about 0.005% to about
0.05% cyclosporin A, castor oil, and Polysorbate 20.
[1124] Another embodiment comprises from about 0.005% to about
0.05% cyclosporin A, castor oil, and Polysorbate 40.
[1125] Another embodiment comprises from about 0.005% to about
0.05% cyclosporin A, castor oil, and Polysorbate 60.
[1126] Another embodiment comprises from about 0.005% to about
0.05% cyclosporin A, castor oil, and Polysorbate 80.
[1127] Another embodiment comprises from about 0.005% to about
0.05% cyclosporin A, castor oil, and a stearate.
[1128] Another embodiment comprises from about 0.005% to about
0.05% cyclosporin A, castor oil, and glyceryl stearate.
[1129] Another embodiment comprises from about 0.005% to about
0.05% cyclosporin A, castor oil, and isopropyl stearate.
[1130] Another embodiment comprises from about 0.005% to about
0.05% cyclosporin A, castor oil, and polyoxyl stearate.
[1131] Another embodiment comprises from about 0.005% to about
0.05% cyclosporin A, castor oil, and propylene glycol stearate.
[1132] Another embodiment comprises from about 0.005% to about
0.05% cyclosporin A, castor oil, and sucrose stearate.
[1133] Another embodiment comprises from about 0.005% to about
0.05% cyclosporin A, castor oil, and polyethylene glycol.
[1134] Another embodiment comprises from about 0.005% to about
0.05% cyclosporin A, castor oil, and polyethylene oxide.
[1135] Another embodiment comprises from about 0.005% to about
0.05% cyclosporin A, castor oil, and polypropylene oxide.
[1136] Another embodiment comprises from about 0.005% to about
0.05% cyclosporin A, castor oil, and a polyethylene
oxide-polypropylene oxide copolymer.
[1137] Another embodiment comprises from about 0.005% to about
0.05% cyclosporin A, castor oil, and an alcohol ethoxylate.
[1138] Another embodiment comprises from about 0.005% to about
0.05% cyclosporin A, castor oil, and an alkylphenol ethoxylate.
[1139] Another embodiment comprises from about 0.005% to about
0.05% cyclosporin A, castor oil, and an alkyl glycoside.
[1140] Another embodiment comprises from about 0.005% to about
0.05% cyclosporin A, castor oil, and alkyl polyglycoside.
[1141] Another embodiment comprises from about 0.005% to about
0.05% cyclosporin A, castor oil, and a fatty alcohol.
[1142] Another embodiment comprises from about 0.005% to about
0.05% cyclosporin A, castor oil, and hydroxypropylmethyl
cellulose.
[1143] Another embodiment comprises from about 0.005% to about
0.05% cyclosporin A, castor oil, and carboxymethyl cellulose.
[1144] Another embodiment comprises from about 0.005% to about
0.05% cyclosporin A, castor oil, and a polyacrylic acid.
[1145] Another embodiment comprises from about 0.005% to about
0.05% cyclosporin A, castor oil, and a Carbomer.
[1146] Another embodiment comprises from about 0.005% to about
0.05% cyclosporin A, castor oil, and a phosphalipid.
[1147] Another embodiment comprises from about 0.005% to about
0.05% cyclosporin A, castor oil, and phosphatidyl chloline.
[1148] Another embodiment comprises from about 0.005% to about
0.05% cyclosporin A, castor oil, and phosphatidyl serine.
[1149] Another embodiment comprises about 0.05% cyclosporin A,
castor oil, and a sorbitan ester.
[1150] Another embodiment comprises about 0.05% cyclosporin A,
castor oil, and Polysorbate 20.
[1151] Another embodiment comprises about 0.05% cyclosporin A,
castor oil, and Polysorbate 40.
[1152] Another embodiment comprises about 0.05% cyclosporin A,
castor oil, and Polysorbate 60.
[1153] Another embodiment comprises about 0.05% cyclosporin A,
castor oil, and Polysorbate 80.
[1154] Another embodiment comprises about 0.05% cyclosporin A,
castor oil, and a stearate.
[1155] Another embodiment comprises about 0.05% cyclosporin A,
castor oil, and glyceryl stearate.
[1156] Another embodiment comprises about 0.05% cyclosporin A,
castor oil, and isopropyl stearate.
[1157] Another embodiment comprises about 0.05% cyclosporin A,
castor oil, and polyoxyl stearate.
[1158] Another embodiment comprises about 0.05% cyclosporin A,
castor oil, and propylene glycol stearate.
[1159] Another embodiment comprises about 0.05% cyclosporin A,
castor oil, and sucrose stearate.
[1160] Another embodiment comprises about 0.05% cyclosporin A,
castor oil, and polyethylene glycol.
[1161] Another embodiment comprises about 0.05% cyclosporin A,
castor oil, and polyethylene oxide.
[1162] Another embodiment comprises about 0.05% cyclosporin A,
castor oil, and polypropylene oxide.
[1163] Another embodiment comprises about 0.05% cyclosporin A,
castor oil, and a polyethylene oxide-polypropylene oxide
copolymer.
[1164] Another embodiment comprises about 0.05% cyclosporin A,
castor oil, and an alcohol ethoxylate.
[1165] Another embodiment comprises about 0.05% cyclosporin A,
castor oil, and an alkylphenol ethoxylate.
[1166] Another embodiment comprises about 0.05% cyclosporin A,
castor oil, and an alkyl glycoside.
[1167] Another embodiment comprises about 0.05% cyclosporin A,
castor oil, and alkyl polyglycoside.
[1168] Another embodiment comprises about 0.05% cyclosporin A,
castor oil, and a fatty alcohol.
[1169] Another embodiment comprises about 0.05% cyclosporin A,
castor oil, and hydroxypropylmethyl cellulose.
[1170] Another embodiment comprises about 0.05% cyclosporin A,
castor oil, and carboxymethyl cellulose.
[1171] Another embodiment comprises about 0.05% cyclosporin A,
castor oil, and a polyacrylic acid.
[1172] Another embodiment comprises about 0.05% cyclosporin A,
castor oil, and a Carbomer.
[1173] Another embodiment comprises about 0.05% cyclosporin A,
castor oil, and a phosphalipid.
[1174] Another embodiment comprises about 0.05% cyclosporin A,
castor oil, and phosphatidyl chloline.
[1175] Another embodiment comprises about 0.05% cyclosporin A,
castor oil, and phosphatidyl serine.
[1176] A liquid which is ophthalmically acceptable is formulated
such that it can be administered topically to the eye. The comfort
should be maximized as much as possible, although sometimes
formulation considerations (e.g. drug stability) may necessitate
less than optimal comfort. In the case that comfort cannot be
maximized, the liquid should be formulated such that the liquid is
tolerable to the patient for topical ophthalmic use. Additionally,
an ophthalmically acceptable liquid should either be packaged for
single use, or contain a preservative to prevent contamination over
multiple uses.
[1177] In accordance with the present invention, the emulsions can
be further stabilized using a polyelectrolyte, or polyelectrolytes
if more than one, from the family of cross-linked polyacrylates,
such as carbomers and Pemulen.RTM..
[1178] Pemulen.RTM. is a registered trademark of B. F. Goodrich for
polymeric emulsifiers and commercially available from B. F.
Goodrich Company, Specialty Polymers & Chemicals Division,
Cleveland, Ohio. Pemulens are Acrylates/C10-30 Alkyl Acrylate
Cross-Polymers. They are high molecular weight co-polymers of
acrylic acid and a long chain alkyl methacrylate cross-linked with
allyl ethers of pentaerythritol. They contain not less than 52.0
percent and not more than 62.0 percent of carboxylic acid groups.
The viscosity of a neutralized 1.0 percent aqueous dispersion is
between 9,500 and 26,500 centipoises.
[1179] In addition, the tonicity of the emulsions can be further
adjusted using glycerine, mannitol, or sorbitol if desired. The pH
of the emulsions can be adjusted in a conventional manner using
sodium hydroxide to a near physiological pH level and while
buffering agents are not required, suitable buffers may include
phosphates, citrates, acetates and borates.
[1180] Examples of useful formulations are shown below.
TABLE-US-00001 Ingredients 1 2 3 4 5 Cyclosporine A 0.1 0.1 0.08
0.03 0.08 Castor oil 1.00 1.2 0.50 0.50 0.50 Clove oil 0.70 Cassia
oil 0.4 0.55 Olive oil 0.35 Mineral Oil 0.80 Polysorbate-80 1.00
0.80 0.30 Diglycerol 0.70 0.20 0.80 Polyglycerol-3 Simulsol OX
1005L 0.60 Brij78 1.20 Glycerin 2.00 1.70 2.00 2.00 2.00 CMC 0.50
0.50 Pemulen TR-2 0.05 0.02 Purified Water QS QS QS QS QS Sodium
Hydroxide pH adj pH adj pH adj pH adj pH adj pH 7.2 7.5 7.1 6.8
7.4
[1181] Another useful emulsion consists of the following: 0.1%
cyclosporin A, 0.20% castor oil, 0.75% polyethylene oxide 40
stearate (Myrj 52.RTM.), 0.2% Polysrobate 80, 1.0% glycerin, 0.6%
boric acid, 0.5% carboxymethylcellulose, 100 ppm stabilized
oxychloro complex (Purites), sufficient sodium hydroxide to adjust
the pH, and the remainder water, wherein the pH is from 7.3 to
7.5.
[1182] Although there has been hereinabove described a particular
pharmaceutical composition in the form of a nonirritating emulsion
for the purpose of illustrating the manner in which the invention
may be used to advantage, it should be appreciated that the
invention is not limited thereto. Accordingly, any and all
modifications, variations, or equivalent arrangements, which may
occur to those skilled in the art, should be considered to be
within the scope of the present invention as defined in the
appended claims.
* * * * *