U.S. patent application number 11/394556 was filed with the patent office on 2006-12-07 for stent, method for processing stent, and method of stenting a patient.
Invention is credited to Wolfgang Daum, Axel Winkel.
Application Number | 20060276876 11/394556 |
Document ID | / |
Family ID | 7954090 |
Filed Date | 2006-12-07 |
United States Patent
Application |
20060276876 |
Kind Code |
A1 |
Daum; Wolfgang ; et
al. |
December 7, 2006 |
Stent, method for processing stent, and method of stenting a
patient
Abstract
The subject invention pertains instruments for use in nuclear
spin tomography comprising a metal alloy comprising aluminum,
vanadium, and titanium. In a specific embodiment, the subject
invention relates to cardiovascular stents which can exhibit a low
incidence of artifacts and are viewable in a nuclear spin
tomography unit. The subject invention also pertains to a method
for processing instruments for use in nuclear spin tomography. Spin
processing can comprise application of a wet chemical etching
solution. In a specific embodiment, the wet chemical etching
solution can comprise three parts hydrochloric acid and two parts
saltpeter acid.
Inventors: |
Daum; Wolfgang; (Groton,
MA) ; Winkel; Axel; (Schwerin, DE) |
Correspondence
Address: |
SALIWANCHIK LLOYD & SALIWANCHIK;A PROFESSIONAL ASSOCIATION
PO BOX 142950
GAINESVILLE
FL
32614-2950
US
|
Family ID: |
7954090 |
Appl. No.: |
11/394556 |
Filed: |
March 31, 2006 |
Related U.S. Patent Documents
|
|
|
|
|
|
Application
Number |
Filing Date |
Patent Number |
|
|
10851931 |
May 21, 2004 |
|
|
|
11394556 |
Mar 31, 2006 |
|
|
|
10091988 |
Mar 5, 2002 |
6780338 |
|
|
10851931 |
May 21, 2004 |
|
|
|
Current U.S.
Class: |
623/1.15 ;
600/420; 623/921 |
Current CPC
Class: |
Y10S 148/051 20130101;
A61L 31/022 20130101; Y10S 623/901 20130101; A61F 2/82 20130101;
A61F 2/86 20130101; Y10T 29/49034 20150115 |
Class at
Publication: |
623/001.15 ;
600/420; 623/921 |
International
Class: |
A61F 2/82 20060101
A61F002/82; A61B 6/12 20060101 A61B006/12 |
Foreign Application Data
Date |
Code |
Application Number |
Mar 9, 2001 |
DE |
20104145.6 |
Claims
1-5. (canceled)
6. A method for control of in-stent-restenosis, comprising:
positioning a stent in a vessel, wherein the stent comprises
TIA13V2.5; and viewing in-stent-restenosis within an inner lumen of
the stent with nuclear spin tomography, wherein the TIA13V2.5
exhibits a low incidence of artifacts in nuclear spin tomography,
wherein viewing in-stent-restenosis within the inner lumen of the
stent with nuclear spin tomography is useful for control of
in-stent-restenosis.
7. The method according to claim 6, wherein the stent consists
essentially entirely of TIA13V2.5.
8. The method according to claim 6, wherein TIA13V2.5 has the
following composition by weight: up to 0.08% C; up to 0.03%
N.sub.2; up to 0.15% O.sub.2; 2.0% to 3.0% V; 2.5% to 3.5% Al; up
to 0.25% Fe; up to 0.015% H.sub.2; and the balance Ti.
9. The method according to claim 7, wherein TIA13V2.5 has the
following composition by weight: up to 0.08% C; up to 0.03%
N.sub.2; up to 0.15% O.sub.2; 2.0% to 3.0% V; 2.5% to 3.5% Al; up
to 0.25% Fe; up to 0.015% H.sub.2; and the balance Ti.
10. A method for control of in-stent-restenosis, comprising:
positioning a stent in a vessel, wherein the stent comprises
TIA16V4; and viewing in-stent-restenosis within an inner lumen of
the stent with nuclear spin tomography, wherein the TIA16V4
exhibits a low incidence of artifacts in nuclear spin tomography,
wherein viewing in-stent-restenosis within the inner lumen of the
stent with nuclear spin tomography is useful for control of
in-stent-restenosis.
11. The method according to claim 10, wherein the stent is
expandable with a balloon catheter.
12. The method according to claim 10, wherein the stent consists
essentially entirely of TIA16V4.
13. The method according to claim 10, wherein the TIA16V4 has the
following composition by weight: up to 0.08% C; up to 0.05%
N.sub.2; up to 0.2% O.sub.2; 3.5% to 4.5% V; 5.5% to 6.75% Al; up
to 0.4% Fe; up to 0.015% H.sub.2; and the balance Ti.
14. The method according to claim 12, wherein the TIA16V4 has the
following composition by weight: up to 0.08% C; up to 0.05%
N.sub.2; up to 0.2% O.sub.2; 3.5% to 4.5% V; 5.5% to 6.75% Al; up
to 0.4% Fe; up to 0.015% H.sub.2; and the balance Ti.
15. A method of stenting a patient, comprising: stenting a patient
with a stent, wherein the stent comprises: TIA13V2.5, wherein the
TIA13V2.5 exhibits a low incidence of artifacts in nuclear spin
tomography.
16. The method according to claim 15, wherein the stent consists
essentially entirely of TIA13V2.5.
17. The method according to claim 15, wherein TIA13V2.5 has the
following composition by weight: up to 0.08% C; up to 0.03%
N.sub.2; up to 0.15% O.sub.2; 2.0% to 3.0% V; 2.5% to 3.5% Al; up
to 0.25% Fe; less than 0.015% H.sub.2; and the balance Ti.
18. The method according to claim 16, wherein TIA13V2.5 has the
following composition by weight: up to 0.08% C; up to 0.03%
N.sub.2; up to 0.15% O.sub.2; 2.0% to 3.0% V; 2.5% to 3.5% Al; up
to 0.25% Fe; up to 0.015% H.sub.2; and the balance Ti.
19. A method of stenting a patient, comprising: stenting a patient
with a stent, wherein the stent comprises TIA16V4, wherein the
TIA16V4 exhibits a low incidence of artifacts in nuclear spin
tomography.
20. The method according to claim 19, wherein the stent is
expandable with a balloon catheter.
21. The method according to claim 19, wherein the stent consists
essentially entirely of TIA16V4.
22. The method according to claim 19, wherein the TIA16V4 has the
following composition by weight: up to 0.08% C; up to 0.05%
N.sub.2; up to 0.2% O.sub.2; 3.5% to 4.5% V; 5.5% to 6.75% Al; up
to 0.4% Fe; up to 0.015% H.sub.2; and the balance Ti.
23. The method according to claim 21, wherein the TIA16V4 has the
following composition by weight: up to 0.08% C; up to 0.05%
N.sub.2; up to 0.2% O.sub.2; 3.5% to 4.5% V; 5.5% to 6.75% Al; up
to 0.4% Fe; up to 0.015% H.sub.2; and the balance Ti.
24. A method of stenting a patient, comprising: stenting a patient
with a stent processed with tools containing magnetizing
components, wherein prior to stenting the patient exposing the
surface of the stent processed with tools containing magnetizing
components to an etching solution that etches the magnetizing
components, wherein exposing the surface of the stent processed
with tools containing magnetizing components reduces surface
magnetism of the stent, wherein reducing surface magnetism of the
stent reduces the occurrence of artifacts from the stent in nuclear
spin tomography.
25. The method according to claim 24, wherein the etching solution
etches iron impurities.
26. The method according to claim 25, wherein the etching solution
comprises: 3 parts hydrochloric acid; and 2 parts saltpeter
acid.
27. The method according to claim 26, wherein the etching solution
further comprises water.
Description
CROSS-REFERENCE TO RELATED APPLICATION
[0001] This application is a divisional application of U.S. patent
application Ser. No. 10/851,931, filed May 21, 2004, which is a
divisional application of U.S. patent application Ser. No.
10/091,988, filed Mar. 5, 2002, now U.S. Pat. No. 6,780,338, which
claims the benefit of German Application Serial No. 20104145.6,
filed Mar. 9, 2001, all of which are hereby incorporated by
reference herein in their entirety, including any figures, tables,
or drawings.
DESCRIPTION
[0002] This invention relates to the use of a material in claim 1
and a process in claims 3 and 5. In today's stent technology it is
desirable to use cardiovascular stents that are able to adequately
prop open the vessel, that can be accurately positioned and that,
and this is new--can be viewed with nuclear spin tomography.
Traditional stents are made of stainless steel and show distinct
image distortions, so called artifacts. These artifacts occur when
materials with high magnetic susceptibility are used.
[0003] A goal of the invention is to show means by which the
occurrence of artifacts in combination with the stents and nuclear
spin tomography can be avoided.
[0004] The solution is recapitulated in claims 1 through 5.
[0005] An alloy of 3 percent aluminum by weight and 2.5 percent
vanadium by weight, with the remainder being titanium, known as
material TIA13V2.5 or material No. 3.7194 or 253.7195 (ASTM Grade
9), shows especially few image artifacts and has sufficient
hardness to be suitable for interventional instruments used in
nuclear spin tomography.
[0006] The above named alloy according to ASTM Grade 9 is harder
than an alloy according to ASTM Grade 5 or ISO 3.765 or 3.7165.
This would have the following components: 90% titanium, 6%
aluminum, and 4% vanadium. The material is more flexible than the
so-called ASTM grade 9 material and is therefore more suitable for
expanding a stent with the help of a balloon catheter.
[0007] Materials that are made to be artifact free but created with
tools containing magnetizing components after processing show an
increase in screen artifacts which rubbed off the tools. A
reduction of surface magnetism can be achieved through dipping in
etching solutions which etches the materials the tools are made of.
The rub-off from the tools is eliminated by the wet chemical
etching solution. Such an etching solution that removes the iron
impurities consists for example of 3 parts hydrochloric acid and 2
parts saltpeter acid and can be further reduced with additional
parts water in the etching process.
[0008] Stents manufactured in the manner here described can be
ideally observed in nuclear spin tomography units in magnetic flux
density >1.0 Testa. It was possible, for example with an
unexpanded stent having a diameter of 1 mm, that was balloon
expanded to a diameter of 4 mm, to clearly see all the stent
struts, the so-called strats. It was also possible to get a good
look inside the expanded stent. So-called in-stent-restenose in the
interior of the stent can be seen when a stent has been treated in
this manner.
* * * * *