U.S. patent application number 11/443904 was filed with the patent office on 2006-09-21 for ldl receptor signaling pathways. This patent application is currently assigned to Board of Regents, The University of Texas System. Invention is credited to Michael Gotthardt, Joachim Herz.
Application Number | 20060211039 11/443904 |
Document ID | / |
Family ID | 24247558 |
Filed Date | 2006-09-21 |
United States Patent Application | 20060211039 |
Kind Code | A1 |
Herz; Joachim ; et al. | September 21, 2006 |
The invention provides methods and compositions for inducing and detecting signal transduction through LDL receptors, including specifically detecting a stress that alters a functional interaction of a low density lipoprotein (LDL) receptor binding polypeptide with an LDL receptor interaction domain, by (a) introducing a predetermined stress into a system which provides a physical interaction of an LDL receptor binding polypeptide with an LDL receptor intracellular binding polypeptide interaction domain, whereby the system provides a stress-biased interaction of the binding polypeptide and the interaction domain, wherein the absence of the stress, the system provides a unbiased interaction of the binding polypeptide and the interaction domain; and (b) detecting the stress-biased interaction of the binding polypeptide and the interaction domain, wherein the binding polypeptide is selected from SEMCAP-1, JIP-1, PSD-95, JIP-2, Talin, OMP25, CAPON, PIP4,5 kinase, Na channel brain 3, Mint1, ICAP-1 and APC subunit10.
Inventors: | Herz; Joachim; (Dallas, TX) ; Gotthardt; Michael; (Dallas, TX) |
Correspondence Address: |
RICHARD ARON OSMAN;SCIENCE AND TECHNOLOGY LAW GROUP 242 AVE VISTA DEL OCEANO SAN CLEMEMTE CA 92672 US |
Assignee: | Board of Regents, The University of
Texas System |
Family ID: | 24247558 |
Appl. No.: | 11/443904 |
Filed: | May 30, 2006 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
10211962 | Aug 1, 2002 | 7056688 | ||
11443904 | May 30, 2006 | |||
09562737 | May 1, 2000 | 6428967 | ||
10211962 | Aug 1, 2002 | |||
Current U.S. Class: | 435/6.12 ; 435/6.13; 435/7.1 |
Current CPC Class: | G01N 33/566 20130101; G01N 33/92 20130101 |
Class at Publication: | 435/006 ; 435/007.1 |
International Class: | C12Q 1/68 20060101 C12Q001/68; G01N 33/53 20060101 G01N033/53 |
Sequence CWU 1
1
132 1 333 PRT Artificial Sequence Description of Artificial
Sequence Synthetic Sequence 1 Met Pro Leu Gly Leu Gly Arg Arg Lys
Lys Ala Pro Pro Leu Val Glu 1 5 10 15 Asn Glu Glu Ala Glu Pro Ser
Arg Ser Gly Leu Gly Val Gly Glu Pro 20 25 30 Gly Pro Leu Gly Gly
Ser Ala Ala Gly Glu Ser Gln Met Gly Leu Pro 35 40 45 Pro Pro Pro
Ala Ala Leu Arg Pro Arg Leu Val Phe His Thr Gln Leu 50 55 60 Ala
His Gly Ser Pro Thr Gly Arg Ile Glu Gly Phe Thr Asn Val Lys 65 70
75 80 Glu Leu Tyr Gly Lys Ile Ala Glu Ala Phe Arg Leu Pro Ala Ala
Glu 85 90 95 Val Met Phe Cys Thr Leu Asn Thr His Lys Val Asp Met
Asp Lys Leu 100 105 110 Leu Gly Gly Gln Ile Gly Leu Glu Asp Phe Ile
Phe Ala His Val Lys 115 120 125 Gly Gln Arg Lys Glu Val Glu Val Phe
Lys Ser Glu Glu Ala Leu Gly 130 135 140 Leu Thr Ile Thr Asp Asn Gly
Ala Gly Tyr Ala Phe Ile Lys Arg Ile 145 150 155 160 Lys Glu Gly Ser
Val Ile Asp His Ile Gln Leu Ile Ser Val Gly Asp 165 170 175 Met Ile
Glu Ala Ile Asn Gly Gln Ser Leu Leu Gly Cys Arg His Tyr 180 185 190
Glu Val Ala Arg Leu Leu Lys Glu Leu Pro Arg Gly Arg Thr Phe Thr 195
200 205 Leu Lys Leu Thr Glu Pro Arg Lys Ala Phe Asp Met Ile Ser Gln
Arg 210 215 220 Ser Ala Gly Gly His Pro Gly Ser Gly Pro Gln Leu Gly
Thr Gly Arg 225 230 235 240 Gly Thr Leu Arg Leu Arg Ser Arg Gly Pro
Ala Thr Val Glu Asp Leu 245 250 255 Pro Ser Ala Phe Glu Glu Lys Ala
Ile Glu Lys Val Asp Asp Leu Leu 260 265 270 Glu Ser Tyr Met Gly Ile
Arg Asp Thr Glu Leu Ala Ala Thr Met Val 275 280 285 Glu Leu Gly Lys
Asp Lys Arg Asn Pro Asp Glu Leu Ala Glu Ala Leu 290 295 300 Asp Glu
Arg Leu Gly Asp Phe Ala Phe Pro Asp Glu Phe Val Phe Asp 305 310 315
320 Val Trp Gly Ala Ile Gly Asp Ala Lys Val Gly Arg Tyr 325 330 2
333 PRT Artificial Sequence Description of Artificial Sequence
Synthetic Sequence 2 Met Ala Leu Gly Leu Gly Arg Arg Lys Lys Ala
Asp Pro Leu Val Glu 1 5 10 15 Asn Glu Glu Ala Glu Glu Ser Arg Ser
Gly Leu Gly Val Gly Glu Phe 20 25 30 Gly Pro Leu Gly Gly Ser Ala
Ala Gly Gly Ser Gln Met Gly Leu Pro 35 40 45 Pro Pro Pro His Ala
Leu Arg Pro Arg Leu Val Phe His Ile Gln Leu 50 55 60 Ala His Gly
Ser Pro Thr Gly Lys Ile Glu Gly Phe Thr Asn Val Lys 65 70 75 80 Glu
Met Tyr Gly Lys Ile Ala Glu Ala Phe Arg Asn Pro Ala Ala Glu 85 90
95 Val Met Phe Cys Thr Gln Asn Thr His Lys Val Asp Met Asp Lys Ser
100 105 110 Leu Gly Gly Gln Ile Gly Leu Glu Asp Thr Ile Phe Ala His
Val Lys 115 120 125 Gly Gln Arg Val Glu Val Glu Val Phe Lys Ser Glu
Glu Trp Leu Gly 130 135 140 Leu Thr Ile Thr Asp Asn Gly Tyr Gly Tyr
Ala Phe Ile Lys Arg Ile 145 150 155 160 Lys Ala Gly Ser Val Ile Asp
His Ile Gln Leu Asp Ser Val Gly Asp 165 170 175 Met Ile Glu Ala Ile
Glu Gly Gln Ser Leu Leu Gly Cys Arg His Phe 180 185 190 Glu Val Ala
Arg Leu Leu Lys Glu Leu Gly Arg Gly Arg Thr Phe Thr 195 200 205 Leu
Lys Leu His Glu Pro Arg Lys Ala Phe Asp Met Ile Ile Gln Arg 210 215
220 Ser Ala Gly Gly His Pro Gly Lys Gly Pro Gln Leu Gly Thr Gly Arg
225 230 235 240 Gly Leu Leu Arg Leu Arg Ser Arg Gly Pro Ala Met Val
Glu Asp Leu 245 250 255 Pro Ser Ala Phe Glu Asn Lys Ala Ile Glu Lys
Val Asp Asp Leu Gln 260 265 270 Glu Ser Tyr Met Gly Ile Arg Asp Thr
Arg Leu Ala Ala Thr Met Val 275 280 285 Glu Leu Gly Ser Asp Lys Arg
Asn Pro Asp Glu Leu Ala Thr Ala Leu 290 295 300 Asp Glu Arg Leu Gly
Asp Phe Val Phe Pro Asp Glu Phe Val Phe Asp 305 310 315 320 Val Tyr
Gly Ala Ile Gly Asp Ala Lys Val Gly Ala Tyr 325 330 3 333 PRT
Artificial Sequence Description of Artificial Sequence Synthetic
Sequence 3 Met Pro Ala Gly Leu Gly Arg Arg Lys Lys Ala Pro Asp Leu
Val Glu 1 5 10 15 Asn Glu Glu Ala Glu Pro Glu Arg Ser Gly Leu Gly
Val Gly Glu Pro 20 25 30 Phe Pro Leu Gly Gly Ser Ala Ala Gly Glu
Gly Gln Met Gly Leu Pro 35 40 45 Pro Pro Pro Ala His Leu Arg Pro
Arg Leu Val Phe His Thr Ile Leu 50 55 60 Ala His Gly Ser Pro Thr
Gly Arg Lys Glu Gly Phe Thr Asn Val Lys 65 70 75 80 Glu Leu Leu Gly
Lys Ile Ala Glu Ala Phe Arg Leu Met Ala Ala Glu 85 90 95 Val Met
Phe Cys Thr Leu Gln Thr His Lys Val Asp Met Asp Lys Leu 100 105 110
Arg Gly Gly Gln Ile Gly Leu Glu Asp Phe Ser Phe Ala His Val Lys 115
120 125 Gly Gln Arg Lys Thr Val Glu Val Phe Lys Ser Glu Glu Ala Val
Gly 130 135 140 Leu Thr Ile Thr Asp Asn Gly Ala Trp Tyr Ala Phe Ile
Lys Arg Ile 145 150 155 160 Lys Glu Tyr Ser Val Ile Asp His Ile Gln
Leu Ile Ala Val Gly Asp 165 170 175 Met Ile Glu Ala Ile Asn Asp Gln
Ser Leu Leu Gly Cys Arg His Tyr 180 185 190 Phe Val Ala Arg Leu Leu
Lys Glu Leu Pro Gly Gly Arg Thr Phe Thr 195 200 205 Leu Lys Leu Thr
His Pro Arg Lys Ala Phe Asp Met Ile Ser Ile Arg 210 215 220 Ser Ala
Gly Gly His Pro Gly Ser Lys Pro Gln Leu Gly Thr Gly Arg 225 230 235
240 Gly Thr Leu Arg Leu Arg Ser Arg Gly Pro Ala Thr Met Glu Asp Leu
245 250 255 Pro Ser Ala Phe Glu Glu Asn Ala Ile Glu Lys Val Asp Asp
Leu Leu 260 265 270 Gln Ser Tyr Met Gly Ile Arg Asp Thr Glu Arg Ala
Ala Thr Met Val 275 280 285 Glu Leu Gly Lys Ser Lys Arg Asn Pro Asp
Glu Leu Ala Glu Thr Leu 290 295 300 Asp Glu Arg Leu Gly Asp Phe Ala
Val Pro Asp Glu Phe Val Phe Asp 305 310 315 320 Val Trp Trp Ala Ile
Gly Asp Ala Lys Val Gly Arg Ala 325 330 4 333 PRT Artificial
Sequence Description of Artificial Sequence Synthetic Sequence 4
Met Pro Leu Ala Leu Gly Arg Arg Lys Lys Ala Pro Pro Asp Val Glu 1 5
10 15 Asn Glu Glu Ala Glu Pro Ser Glu Ser Gly Leu Gly Val Gly Glu
Pro 20 25 30 Gly Phe Leu Gly Gly Ser Ala Ala Gly Glu Ser Gly Met
Gly Leu Pro 35 40 45 Pro Pro Pro Ala Ala His Arg Pro Arg Leu Val
Phe His Thr Gln Ile 50 55 60 Ala His Gly Ser Pro Thr Gly Arg Ile
Lys Gly Phe Thr Asn Val Lys 65 70 75 80 Glu Leu Tyr Leu Lys Ile Ala
Glu Ala Phe Arg Leu Pro Met Ala Glu 85 90 95 Val Met Phe Cys Thr
Leu Asn Asn His Lys Val Asp Met Asp Lys Leu 100 105 110 Leu Gln Gly
Gln Ile Gly Leu Glu Asp Phe Ile Arg Ala His Val Lys 115 120 125 Gly
Gln Arg Lys Glu Ser Glu Val Phe Lys Ser Glu Glu Ala Leu Thr 130 135
140 Leu Thr Ile Thr Asp Asn Gly Ala Gly Val Ala Phe Ile Lys Arg Ile
145 150 155 160 Lys Glu Gly Trp Val Ile Asp His Ile Gln Leu Ile Ser
Tyr Gly Asp 165 170 175 Met Ile Glu Ala Ile Asn Gly Ala Ser Leu Leu
Gly Cys Arg His Tyr 180 185 190 Glu Asp Ala Arg Leu Leu Lys Glu Leu
Pro Arg Glu Arg Thr Phe Thr 195 200 205 Leu Lys Leu Thr Glu Phe Arg
Lys Ala Phe Asp Met Ile Ser Gln Gly 210 215 220 Ser Ala Gly Gly His
Pro Gly Ser Gly His Gln Leu Gly Thr Gly Arg 225 230 235 240 Gly Thr
Leu Ile Leu Arg Ser Arg Gly Pro Ala Thr Val Lys Asp Leu 245 250 255
Pro Ser Ala Phe Glu Glu Lys Leu Ile Glu Lys Val Asp Asp Leu Leu 260
265 270 Glu Met Tyr Met Gly Ile Arg Asp Thr Glu Leu Asn Ala Thr Met
Val 275 280 285 Glu Leu Gly Lys Asp Gln Arg Asn Pro Asp Glu Leu Ala
Glu Ala Arg 290 295 300 Asp Glu Arg Leu Gly Asp Phe Ala Phe Ser Asp
Glu Phe Val Phe Asp 305 310 315 320 Val Trp Gly Thr Ile Gly Asp Ala
Lys Val Gly Arg Tyr 325 330 5 333 PRT Artificial Sequence
Description of Artificial Sequence Synthetic Sequence 5 Met Pro Leu
Gly Ala Gly Arg Arg Lys Lys Ala Pro Pro Leu Asp Glu 1 5 10 15 Asn
Glu Glu Ala Glu Pro Ser Arg Glu Gly Leu Gly Val Gly Glu Pro 20 25
30 Gly Pro Phe Gly Gly Ser Ala Ala Gly Glu Ser Gln Gly Gly Leu Pro
35 40 45 Pro Pro Pro Ala Ala Leu His Pro Arg Leu Val Phe His Thr
Gln Leu 50 55 60 Ile His Gly Ser Pro Thr Gly Arg Ile Glu Lys Phe
Thr Asn Val Lys 65 70 75 80 Glu Leu Tyr Gly Leu Ile Ala Glu Ala Phe
Arg Leu Pro Ala Met Glu 85 90 95 Val Met Phe Cys Thr Leu Asn Thr
Asn Lys Val Asp Met Asp Lys Leu 100 105 110 Leu Gly Gln Gln Ile Gly
Leu Glu Asp Phe Ile Phe Arg His Val Lys 115 120 125 Gly Gln Arg Lys
Glu Val Ser Val Phe Lys Ser Glu Glu Ala Leu Gly 130 135 140 Thr Thr
Ile Thr Asp Asn Gly Ala Gly Tyr Val Phe Ile Lys Arg Ile 145 150 155
160 Lys Glu Gly Ser Trp Ile Asp His Ile Gln Leu Ile Ser Val Tyr Asp
165 170 175 Met Ile Glu Ala Ile Asn Gly Gln Ala Leu Leu Gly Cys Arg
His Tyr 180 185 190 Glu Val Asp Arg Leu Leu Lys Glu Leu Pro Arg Gly
Glu Thr Phe Thr 195 200 205 Leu Lys Leu Thr Glu Pro Phe Lys Ala Phe
Asp Met Ile Ser Gln Arg 210 215 220 Gly Ala Gly Gly His Pro Gly Ser
Gly Pro His Leu Gly Thr Gly Arg 225 230 235 240 Gly Thr Leu Arg Ile
Arg Ser Arg Gly Pro Ala Thr Val Glu Lys Leu 245 250 255 Pro Ser Ala
Phe Glu Glu Lys Ala Leu Glu Lys Val Asp Asp Leu Leu 260 265 270 Glu
Ser Met Met Gly Ile Arg Asp Thr Glu Leu Ala Asn Thr Met Val 275 280
285 Glu Leu Gly Lys Asp Lys Gln Asn Pro Asp Glu Leu Ala Glu Ala Leu
290 295 300 Arg Glu Arg Leu Gly Asp Phe Ala Phe Pro Ser Glu Phe Val
Phe Asp 305 310 315 320 Val Trp Gly Ala Thr Gly Asp Ala Lys Val Gly
Arg Tyr 325 330 6 333 PRT Artificial Sequence Description of
Artificial Sequence Synthetic Sequence 6 Met Pro Leu Gly Leu Ala
Arg Arg Lys Lys Ala Pro Pro Leu Val Asp 1 5 10 15 Asn Glu Glu Ala
Glu Pro Ser Arg Ser Glu Leu Gly Val Gly Glu Pro 20 25 30 Gly Pro
Leu Phe Gly Ser Ala Ala Gly Glu Ser Gln Met His Leu Pro 35 40 45
Pro Pro Pro Ala Ala Leu Arg Ile Arg Leu Val Phe His Thr Gln Leu 50
55 60 Ala Lys Gly Ser Pro Thr Gly Arg Ile Glu Gly Leu Thr Asn Val
Lys 65 70 75 80 Glu Leu Tyr Gly Lys Met Ala Glu Ala Phe Arg Leu Pro
Ala Ala Asn 85 90 95 Val Met Phe Cys Thr Leu Asn Thr His Gln Val
Asp Met Asp Lys Leu 100 105 110 Leu Gly Gly Arg Ile Gly Leu Glu Asp
Phe Ile Phe Ala Ser Val Lys 115 120 125 Gly Gln Arg Lys Glu Val Glu
Thr Phe Lys Ser Glu Glu Ala Leu Gly 130 135 140 Leu Val Ile Thr Asp
Asn Gly Ala Gly Tyr Ala Trp Ile Lys Arg Ile 145 150 155 160 Lys Glu
Gly Ser Val Tyr Asp His Ile Gln Leu Ile Ser Val Gly Ala 165 170 175
Met Ile Glu Ala Ile Asn Gly Gln Ser Asp Leu Gly Cys Arg His Tyr 180
185 190 Glu Val Ala Glu Leu Leu Lys Glu Leu Pro Arg Gly Arg Phe Phe
Thr 195 200 205 Leu Lys Leu Thr Glu Pro Arg Gly Ala Phe Asp Met Ile
Ser Gln Arg 210 215 220 Ser His Gly Gly His Pro Gly Ser Gly Pro Gln
Ile Gly Thr Gly Arg 225 230 235 240 Gly Thr Leu Arg Leu Lys Ser Arg
Gly Pro Ala Thr Val Glu Asp Met 245 250 255 Pro Ser Ala Phe Glu Glu
Lys Ala Ile Asn Lys Val Asp Asp Leu Leu 260 265 270 Glu Ser Tyr Gln
Gly Ile Arg Asp Thr Glu Leu Ala Ala Arg Met Val 275 280 285 Glu Leu
Gly Lys Asp Lys Arg Ser Pro Asp Glu Leu Ala Glu Ala Leu 290 295 300
Asp Thr Arg Leu Gly Asp Phe Ala Phe Pro Asp Val Phe Val Phe Asp 305
310 315 320 Val Trp Gly Ala Ile Trp Asp Ala Lys Val Gly Arg Tyr 325
330 7 333 PRT Artificial Sequence Description of Artificial
Sequence Synthetic Sequence 7 Met Pro Leu Gly Leu Gly Ala Arg Lys
Lys Ala Pro Pro Leu Val Glu 1 5 10 15 Asp Glu Glu Ala Glu Pro Ser
Arg Ser Gly Glu Gly Val Gly Glu Pro 20 25 30 Gly Pro Leu Gly Phe
Ser Ala Ala Gly Glu Ser Gln Met Gly Gly Pro 35 40 45 Pro Pro Pro
Ala Ala Leu Arg Pro His Leu Val Phe His Thr Gln Leu 50 55 60 Ala
His Ile Ser Pro Thr Gly Arg Ile Glu Gly Phe Lys Asn Val Lys 65 70
75 80 Glu Leu Tyr Gly Lys Ile Leu Glu Ala Phe Arg Leu Pro Ala Ala
Glu 85 90 95 Met Met Phe Cys Thr Leu Asn Thr His Lys Asn Asp Met
Asp Lys Leu 100 105 110 Leu Gly Gly Gln Gln Gly Leu Glu Asp Phe Ile
Phe Ala His Arg Lys 115 120 125 Gly Gln Arg Lys Glu Val Glu Val Ser
Lys Ser Glu Glu Ala Leu Gly 130 135 140 Leu Thr Thr Thr Asp Asn Gly
Ala Gly Tyr Ala Phe Val Lys Arg Ile 145 150 155 160 Lys Glu Gly Ser
Val Ile Trp His Ile Gln Leu Ile Ser Val Gly Asp 165 170 175 Tyr Ile
Glu Ala Ile Asn Gly Gln Ser Leu Ala Gly Cys Arg His Tyr 180 185 190
Glu Val Ala Arg Asp Leu Lys Glu Leu Pro Arg Gly Arg Thr Glu Thr 195
200 205 Leu Lys Leu Thr Glu Pro Arg Lys Phe Phe Asp Met Ile Ser Gln
Arg 210 215 220 Ser Ala His Gly His Pro Gly Ser Gly Pro Gln Leu Ile
Thr Gly Arg 225 230 235 240 Gly Thr Leu Arg Leu Arg Lys Arg Gly Pro
Ala Thr Val Glu Asp Leu 245 250 255 Leu Ser Ala Phe Glu Glu Lys Ala
Ile Glu Met Val Asp Asp Leu Leu 260 265 270 Glu Ser Tyr Met Asn Ile
Arg Asp Thr Glu Leu Ala Ala Thr Gln Val 275 280 285 Glu Leu Gly Lys
Asp Lys Arg Asn Arg Asp Glu Leu Ala Glu Ala Leu 290 295 300 Asp Glu
Ser Leu Gly Asp Phe Ala Phe Pro Asp Glu Thr Val Phe Asp 305 310 315
320 Val Trp Gly Ala Ile Gly Val Ala Lys Val Gly Arg Tyr 325 330 8
333 PRT Artificial Sequence Description of Artificial Sequence
Synthetic Sequence 8 Met Pro Leu Gly Leu Gly Arg Ala Lys Lys Ala
Pro Pro Leu Val Glu 1 5 10 15 Asn Asp Glu Ala Glu Pro Ser Arg
Ser Gly Leu Glu Val Gly Glu Pro 20 25 30 Gly Pro Leu Gly Gly Phe
Ala Ala Gly Glu Ser Gln Met Gly Leu Gly 35 40 45 Pro Pro Pro Ala
Ala Leu Arg Pro Arg His Val Phe His Thr Gln Leu 50 55 60 Ala His
Gly Ile Pro Thr Gly Arg Ile Glu Gly Phe Thr Lys Val Lys 65 70 75 80
Glu Leu Tyr Gly Lys Ile Ala Leu Ala Phe Arg Leu Pro Ala Ala Glu 85
90 95 Val Asn Phe Cys Thr Leu Asn Thr His Lys Val Gln Met Asp Lys
Leu 100 105 110 Leu Gly Gly Gln Ile Arg Leu Glu Asp Phe Ile Phe Ala
His Val Ser 115 120 125 Gly Gln Arg Lys Glu Val Glu Val Phe Thr Ser
Glu Glu Ala Leu Gly 130 135 140 Leu Thr Ile Val Asp Asn Gly Ala Gly
Tyr Ala Phe Ile Trp Arg Ile 145 150 155 160 Lys Glu Gly Ser Val Ile
Asp Tyr Ile Gln Leu Ile Ser Val Gly Asp 165 170 175 Met Ala Glu Ala
Ile Asn Gly Gln Ser Leu Leu Asp Cys Arg His Tyr 180 185 190 Glu Val
Ala Arg Leu Glu Lys Glu Leu Pro Arg Gly Arg Thr Phe Phe 195 200 205
Leu Lys Leu Thr Glu Pro Arg Lys Ala Gly Asp Met Ile Ser Gln Arg 210
215 220 Ser Ala Gly His His Pro Gly Ser Gly Pro Gln Leu Gly Ile Gly
Arg 225 230 235 240 Gly Thr Leu Arg Leu Arg Ser Lys Gly Pro Ala Thr
Val Glu Asp Leu 245 250 255 Pro Leu Ala Phe Glu Glu Lys Ala Ile Glu
Lys Met Asp Asp Leu Leu 260 265 270 Glu Ser Tyr Met Gly Asn Arg Asp
Thr Glu Leu Ala Ala Thr Met Gln 275 280 285 Glu Leu Gly Lys Asp Lys
Arg Asn Pro Arg Glu Leu Ala Glu Ala Leu 290 295 300 Asp Glu Arg Ser
Gly Asp Phe Ala Phe Pro Asp Glu Phe Thr Phe Asp 305 310 315 320 Val
Trp Gly Ala Ile Gly Asp Val Lys Val Gly Arg Tyr 325 330 9 333 PRT
Artificial Sequence Description of Artificial Sequence Synthetic
Sequence 9 Met Pro Leu Gly Leu Gly Arg Arg Ala Lys Ala Pro Pro Leu
Val Glu 1 5 10 15 Asn Glu Asp Ala Glu Pro Ser Arg Ser Gly Leu Gly
Glu Gly Glu Pro 20 25 30 Gly Pro Leu Gly Gly Ser Phe Ala Gly Glu
Ser Gln Met Gly Leu Pro 35 40 45 Gly Pro Pro Ala Ala Leu Arg Pro
Arg Leu His Phe His Thr Gln Leu 50 55 60 Ala His Gly Ser Ile Thr
Gly Arg Ile Glu Gly Phe Thr Asn Lys Lys 65 70 75 80 Glu Leu Tyr Gly
Lys Ile Ala Glu Leu Phe Arg Leu Pro Ala Ala Glu 85 90 95 Val Met
Met Cys Thr Leu Asn Thr His Lys Val Asp Asn Asp Lys Leu 100 105 110
Leu Gly Gly Gln Ile Gly Gln Glu Asp Phe Ile Phe Ala His Val Lys 115
120 125 Arg Gln Arg Lys Glu Val Glu Val Phe Lys Thr Glu Glu Ala Leu
Gly 130 135 140 Leu Thr Ile Thr Val Asn Gly Ala Gly Tyr Ala Phe Ile
Lys Trp Ile 145 150 155 160 Lys Glu Gly Ser Val Ile Asp His Tyr Gln
Leu Ile Ser Val Gly Asp 165 170 175 Met Ile Ala Ala Ile Asn Gly Gln
Ser Leu Leu Gly Asp Arg His Tyr 180 185 190 Glu Val Ala Arg Leu Leu
Glu Glu Leu Pro Arg Gly Arg Thr Phe Thr 195 200 205 Phe Lys Leu Thr
Glu Pro Arg Lys Ala Phe Gly Met Ile Ser Gln Arg 210 215 220 Ser Ala
Gly Gly Ile Pro Gly Ser Gly Pro Gln Leu Gly Thr Lys Arg 225 230 235
240 Gly Thr Leu Arg Leu Arg Ser Arg Leu Pro Ala Thr Val Glu Asp Leu
245 250 255 Pro Ser Met Phe Glu Glu Lys Ala Ile Glu Lys Val Asn Asp
Leu Leu 260 265 270 Glu Ser Tyr Met Gly Ile Gln Asp Thr Glu Leu Ala
Ala Thr Met Val 275 280 285 Arg Leu Gly Lys Asp Lys Arg Asn Pro Asp
Ser Leu Ala Glu Ala Leu 290 295 300 Asp Glu Arg Leu Thr Asp Phe Ala
Phe Pro Asp Glu Phe Val Val Asp 305 310 315 320 Val Trp Gly Ala Ile
Gly Asp Ala Trp Val Gly Arg Tyr 325 330 10 333 PRT Artificial
Sequence Description of Artificial Sequence Synthetic Sequence 10
Met Pro Leu Gly Leu Gly Arg Arg Lys Ala Ala Pro Pro Leu Val Glu 1 5
10 15 Asn Glu Glu Asp Glu Pro Ser Arg Ser Gly Leu Gly Val Glu Glu
Pro 20 25 30 Gly Pro Leu Gly Gly Ser Ala Phe Gly Glu Ser Gln Met
Gly Leu Pro 35 40 45 Pro Gly Pro Ala Ala Leu Arg Pro Arg Leu Val
His His Thr Gln Leu 50 55 60 Ala His Gly Ser Pro Ile Gly Arg Ile
Glu Gly Phe Thr Asn Val Leu 65 70 75 80 Glu Leu Tyr Gly Lys Ile Ala
Glu Ala Met Arg Leu Pro Ala Ala Glu 85 90 95 Val Met Phe Asn Thr
Leu Asn Thr His Lys Val Asp Met Gln Lys Leu 100 105 110 Leu Gly Gly
Gln Ile Gly Leu Arg Asp Phe Ile Phe Ala His Val Lys 115 120 125 Gly
Ser Arg Lys Glu Val Glu Val Phe Lys Ser Thr Glu Ala Leu Gly 130 135
140 Leu Thr Ile Thr Asp Val Gly Ala Gly Tyr Ala Phe Ile Lys Arg Trp
145 150 155 160 Lys Glu Gly Ser Val Ile Asp His Ile Tyr Leu Ile Ser
Val Gly Asp 165 170 175 Met Ile Glu Asp Ile Asn Gly Gln Ser Leu Leu
Gly Cys Glu His Tyr 180 185 190 Glu Val Ala Arg Leu Leu Lys Phe Leu
Pro Arg Gly Arg Thr Phe Thr 195 200 205 Leu Gly Leu Thr Glu Pro Arg
Lys Ala Phe Asp His Ile Ser Gln Arg 210 215 220 Ser Ala Gly Gly His
Ile Gly Ser Gly Pro Gln Leu Gly Thr Gly Lys 225 230 235 240 Gly Thr
Leu Arg Leu Arg Ser Arg Gly Leu Ala Thr Val Glu Asp Leu 245 250 255
Pro Ser Ala Met Glu Glu Lys Ala Ile Glu Lys Val Asp Asn Leu Leu 260
265 270 Glu Ser Tyr Met Gly Ile Arg Gln Thr Glu Leu Ala Ala Thr Met
Val 275 280 285 Glu Arg Gly Lys Asp Lys Arg Asn Pro Asp Glu Ser Ala
Glu Ala Leu 290 295 300 Asp Glu Arg Leu Gly Thr Phe Ala Phe Pro Asp
Glu Phe Val Phe Val 305 310 315 320 Val Trp Gly Ala Ile Gly Asp Ala
Lys Trp Gly Arg Tyr 325 330 11 659 PRT Artificial Sequence
Description of Artificial Sequence Synthetic Sequence 11 Met Ala
Glu Arg Glu Ser Gly Leu Gly Gly Gly Ala Ala Ser Pro Pro 1 5 10 15
Ala Ala Ser Pro Phe Leu Gly Leu His Ile Ala Ser Pro Pro Asn Phe 20
25 30 Arg Leu Thr His Asp Ile Ser Leu Glu Glu Phe Glu Asp Glu Asp
Leu 35 40 45 Ser Glu Ile Thr Asp Glu Cys Gly Ile Ser Leu Gln Cys
Lys Asp Thr 50 55 60 Leu Ser Leu Arg Pro Pro Arg Ala Gly Leu Leu
Ser Ala Gly Ser Ser 65 70 75 80 Gly Ser Ala Gly Ser Arg Leu Gln Ala
Glu Met Leu Gln Met Asp Leu 85 90 95 Ile Asp Ala Ala Gly Asp Thr
Pro Gly Ala Glu Asp Asp Glu Glu Glu 100 105 110 Glu Asp Asp Glu Leu
Ala Ala Gln Arg Pro Gly Val Gly Pro Pro Lys 115 120 125 Ala Glu Ser
Asn Gln Asp Pro Ala Pro Arg Ser Gln Gly Gln Gly Pro 130 135 140 Gly
Thr Gly Ser Gly Asp Thr Tyr Arg Pro Lys Arg Pro Thr Thr Leu 145 150
155 160 Asn Leu Phe Pro Gln Val Pro Arg Ser Gln Asp Thr Leu Asn Asn
Asn 165 170 175 Ser Leu Gly Lys Lys His Ser Trp Gln Asp Arg Val Ser
Arg Ser Ser 180 185 190 Ser Pro Leu Lys Thr Gly Glu Gln Thr Pro Pro
His Glu His Ile Cys 195 200 205 Leu Ser Asp Glu Leu Pro Pro Gln Gly
Ser Pro Val Pro Thr Gln Asp 210 215 220 Arg Gly Thr Ser Thr Asp Ser
Pro Cys Arg Arg Ser Ala Ala Thr Gln 225 230 235 240 Met Ala Pro Pro
Ser Gly Pro Pro Ala Thr Ala Pro Gly Gly Arg Gly 245 250 255 His Ser
His Arg Asp Arg Ile His Tyr Gln Ala Asp Val Arg Leu Glu 260 265 270
Ala Thr Glu Glu Ile Tyr Leu Thr Pro Val Gln Arg Pro Pro Asp Pro 275
280 285 Ala Glu Pro Thr Ser Thr Phe Met Pro Pro Thr Glu Ser Arg Met
Ser 290 295 300 Val Ser Ser Asp Pro Asp Pro Ala Ala Tyr Ser Val Thr
Ala Gly Arg 305 310 315 320 Pro His Pro Ser Ile Ser Glu Glu Asp Glu
Gly Phe Asp Cys Leu Ser 325 330 335 Ser Pro Glu Arg Ala Glu Pro Pro
Gly Gly Gly Trp Arg Gly Ser Leu 340 345 350 Gly Glu Pro Pro Pro Pro
Pro Arg Ala Ser Leu Ser Ser Asp Thr Ser 355 360 365 Ala Leu Ser Tyr
Asp Ser Val Lys Tyr Thr Leu Val Val Asp Glu His 370 375 380 Ala Gln
Leu Glu Leu Val Ser Leu Arg Pro Cys Phe Gly Asp Tyr Ser 385 390 395
400 Asp Glu Ser Asp Ser Ala Thr Val Tyr Asp Asn Cys Ala Ser Ala Ser
405 410 415 Ser Pro Tyr Glu Ser Ala Ile Gly Glu Glu Tyr Glu Glu Ala
Pro Gln 420 425 430 Pro Arg Pro Pro Thr Cys Leu Ser Glu Asp Ser Thr
Pro Asp Glu Pro 435 440 445 Asp Val Phe Ser Lys Lys Phe Leu Asn Val
Phe Met Ser Gly Arg Ser 450 455 460 Arg Ser Ser Ser Ala Glu Ser Phe
Gly Leu Phe Ser Cys Val Ile Asn 465 470 475 480 Gly Glu Glu His Glu
Gln Thr His Arg Ala Ile Phe Arg Phe Val Pro 485 490 495 Arg His Glu
Asp Glu Leu Glu Leu Glu Val Asp Asp Pro Leu Leu Val 500 505 510 Glu
Leu Gln Ala Glu Asp Tyr Trp Tyr Glu Ala Tyr Asn Met Arg Thr 515 520
525 Gly Ala Arg Gly Val Phe Pro Ala Tyr Tyr Ala Ile Glu Val Thr Lys
530 535 540 Glu Pro Glu His Met Ala Ala Leu Ala Lys Asn Ser Cys Val
Leu Glu 545 550 555 560 Ile Ser Val Arg Gly Val Lys Ile Gly Val Lys
Ala Asp Asp Ala Leu 565 570 575 Glu Ala Lys Gly Asn Lys Cys Ser His
Phe Phe Gln Leu Lys Asn Ile 580 585 590 Ser Phe Cys Gly Tyr His Pro
Lys Asn Asn Lys Tyr Phe Gly Phe Ile 595 600 605 Thr Lys His Pro Ala
Asp His Arg Phe Ala Cys His Val Phe Val Ser 610 615 620 Glu Asp Ser
Thr Lys Ala Leu Ala Glu Ser Val Gly Arg Ala Phe Gln 625 630 635 640
Gln Phe Tyr Lys Gln Phe Val Glu Tyr Thr Cys Pro Thr Glu Asp Ile 645
650 655 Tyr Leu Glu 12 659 PRT Artificial Sequence Description of
Artificial Sequence Synthetic Sequence 12 Met Asp Glu Arg Glu Ser
Gly Leu Gly Gly Gly Glu Ala Ser Pro Pro 1 5 10 15 Ala Ala Ser Pro
Phe Phe Gly Leu His Ile Ala Ser Pro Pro Asn Gly 20 25 30 Arg Leu
Thr His Asp Ile Ser Leu Glu His Phe Glu Asp Glu Asp Leu 35 40 45
Ser Glu Ile Ile Asp Glu Cys Gly Ile Ser Leu Gln Cys Leu Asp Thr 50
55 60 Leu Ser Leu Arg Pro Pro Arg Met Gly Leu Leu Ser Ala Gly Ser
Ser 65 70 75 80 Gly Asn Ala Gly Ser Arg Leu Gln Ala Glu Met Gln Gln
Met Asp Leu 85 90 95 Ile Asp Ala Ala Gly Arg Thr Pro Gly Ala Glu
Asp Asp Glu Glu Ser 100 105 110 Glu Asp Asp Glu Leu Ala Ala Gln Arg
Thr Gly Val Gly Pro Pro Lys 115 120 125 Ala Glu Ser Val Gln Asp Pro
Ala Pro Arg Ser Gln Gly Trp Gly Pro 130 135 140 Gly Thr Gly Ser Gly
Asp Thr Ala Arg Pro Lys Arg Pro Thr Thr Leu 145 150 155 160 Asn Asp
Phe Pro Gln Val Pro Arg Ser Gln Asp Glu Leu Asn Asn Asn 165 170 175
Ser Leu Gly Lys Lys Phe Ser Trp Gln Asp Arg Val Ser Arg Ser Gly 180
185 190 Ser Pro Leu Lys Thr Gly Glu Gln Thr His Pro His Glu His Ile
Cys 195 200 205 Leu Ser Asp Ile Leu Pro Pro Gln Gly Ser Pro Val Pro
Lys Gln Asp 210 215 220 Arg Gly Thr Ser Thr Asp Ser Leu Cys Arg Arg
Ser Ala Ala Thr Gln 225 230 235 240 Met Met Pro Pro Ser Gly Pro Pro
Ala Thr Ala Asn Gly Gly Arg Gly 245 250 255 His Ser His Arg Asp Gln
Ile His Tyr Gln Ala Asp Val Arg Leu Arg 260 265 270 Ala Thr Glu Glu
Ile Tyr Leu Thr Pro Ser Gln Arg Pro Pro Asp Pro 275 280 285 Ala Glu
Pro Val Ser Thr Phe Met Pro Pro Thr Glu Ser Trp Met Ser 290 295 300
Val Ser Ser Asp Pro Asp Pro Tyr Ala Tyr Ser Val Thr Ala Gly Arg 305
310 315 320 Pro Ala Pro Ser Ile Ser Glu Glu Asp Glu Gly Asp Asp Cys
Leu Ser 325 330 335 Ser Pro Glu Arg Ala Phe Pro Pro Gly Gly Gly Trp
Arg Gly Ser Gly 340 345 350 Gly Glu Pro Pro Pro Pro Pro Arg Ala His
Leu Ser Ser Asp Thr Ser 355 360 365 Ala Leu Ser Ile Asp Ser Val Lys
Tyr Thr Leu Val Val Lys Glu His 370 375 380 Ala Gln Leu Glu Leu Val
Ser Met Arg Pro Cys Phe Gly Asp Tyr Ser 385 390 395 400 Asp Asn Ser
Asp Ser Ala Thr Val Tyr Asp Asn Gln Ala Ser Ala Ser 405 410 415 Ser
Pro Tyr Glu Ser Arg Ile Gly Glu Glu Tyr Glu Glu Ala Pro Ser 420 425
430 Pro Arg Pro Pro Thr Cys Leu Ser Glu Thr Ser Thr Pro Asp Glu Pro
435 440 445 Asp Val Phe Val Lys Lys Phe Leu Asn Val Phe Met Ser Trp
Arg Ser 450 455 460 Arg Ser Ser Ser Ala Glu Ser Tyr Gly Leu Phe Ser
Cys Val Ile Asn 465 470 475 480 Gly Ala Glu His Glu Gln Thr His Arg
Ala Ile Asp Arg Phe Val Pro 485 490 495 Arg His Glu Asp Glu Glu Glu
Leu Glu Val Asp Asp Pro Leu Leu Phe 500 505 510 Glu Leu Gln Ala Glu
Asp Tyr Trp Tyr Gly Ala Tyr Asn Met Arg Thr 515 520 525 Gly Ala Arg
His Val Phe Pro Ala Tyr Tyr Ala Ile Glu Ile Thr Lys 530 535 540 Glu
Pro Glu His Met Ala Ala Lys Ala Lys Asn Ser Cys Val Leu Glu 545 550
555 560 Ile Leu Val Arg Gly Val Lys Ile Gly Val Lys Met Asp Asp Ala
Leu 565 570 575 Glu Ala Lys Gly Asn Asn Cys Ser His Phe Phe Gln Leu
Lys Asn Gln 580 585 590 Ser Phe Cys Gly Tyr His Pro Lys Asn Arg Lys
Tyr Phe Gly Phe Ile 595 600 605 Thr Lys His Ser Ala Asp His Arg Phe
Ala Cys His Val Thr Val Ser 610 615 620 Glu Asp Ser Thr Lys Ala Leu
Val Glu Ser Val Gly Arg Ala Phe Gln 625 630 635 640 Gln Trp Tyr Lys
Gln Phe Val Glu Tyr Thr Cys Tyr Thr Glu Asp Ile 645 650 655 Tyr Leu
Glu 13 659 PRT Artificial Sequence Description of Artificial
Sequence Synthetic Sequence 13 Met Ala Ala Arg Glu Ser Gly Leu Gly
Gly Gly Ala Asp Ser Pro Pro 1 5 10 15 Ala Ala Ser Pro Phe Leu Glu
Leu His Ile Ala Ser Pro Pro Asn Phe 20 25 30 Phe Leu Thr His Asp
Ile Ser Leu Glu Glu Gly Glu Asp Glu Asp Leu 35 40 45 Ser Glu Ile
Thr His Glu Cys Gly Ile Ser Leu Gln Cys Lys Ile Thr 50 55 60 Leu
Ser Leu Arg Pro Pro Arg Ala Lys Leu Leu Ser Ala Gly Ser Ser 65 70
75 80 Gly Ser Leu Gly Ser Arg Leu Gln Ala Glu Met Leu Met Met Asp
Leu 85
90 95 Ile Asp Ala Ala Gly Asp Asn Pro Gly Ala Glu Asp Asp Glu Glu
Glu 100 105 110 Gln Asp Asp Glu Leu Ala Ala Gln Arg Pro Arg Val Gly
Pro Pro Lys 115 120 125 Ala Glu Ser Asn Ser Asp Pro Ala Pro Arg Ser
Gln Gly Gln Thr Pro 130 135 140 Gly Thr Gly Ser Gly Asp Thr Tyr Val
Pro Lys Arg Pro Thr Thr Leu 145 150 155 160 Asn Leu Trp Pro Gln Val
Pro Arg Ser Gln Asp Thr Tyr Asn Asn Asn 165 170 175 Ser Leu Gly Lys
Lys His Ala Trp Gln Asp Arg Val Ser Arg Ser Ser 180 185 190 Asp Pro
Leu Lys Thr Gly Glu Gln Thr Pro Glu His Glu His Ile Cys 195 200 205
Leu Ser Asp Glu Phe Pro Pro Gln Gly Ser Pro Val Pro Thr Gly Asp 210
215 220 Arg Gly Thr Ser Thr Asp Ser Pro His Arg Arg Ser Ala Ala Thr
Gln 225 230 235 240 Met Ala Ile Pro Ser Gly Pro Pro Ala Thr Ala Pro
Lys Gly Arg Gly 245 250 255 His Ser His Arg Asp Arg Leu His Tyr Gln
Ala Asp Val Arg Leu Glu 260 265 270 Met Thr Glu Glu Ile Tyr Leu Thr
Pro Val Asn Arg Pro Pro Asp Pro 275 280 285 Ala Glu Pro Thr Gln Thr
Phe Met Pro Pro Thr Glu Ser Arg Arg Ser 290 295 300 Val Ser Ser Asp
Pro Asp Pro Ala Ser Tyr Ser Val Thr Ala Gly Arg 305 310 315 320 Pro
His Thr Ser Ile Ser Glu Glu Asp Glu Gly Phe Val Cys Leu Ser 325 330
335 Ser Pro Glu Arg Ala Glu Trp Pro Gly Gly Gly Trp Arg Gly Ser Leu
340 345 350 Tyr Glu Pro Pro Pro Pro Pro Arg Ala Ser Ala Ser Ser Asp
Thr Ser 355 360 365 Ala Leu Ser Tyr Asp Ser Val Lys Tyr Thr Leu Val
Val Asp Phe His 370 375 380 Ala Gln Leu Glu Leu Val Ser Leu Gly Pro
Cys Phe Gly Asp Tyr Ser 385 390 395 400 Asp Glu His Asp Ser Ala Thr
Val Tyr Asp Asn Cys Ile Ser Ala Ser 405 410 415 Ser Pro Tyr Glu Ser
Ala Lys Gly Glu Glu Tyr Glu Glu Ala Pro Gln 420 425 430 Leu Arg Pro
Pro Thr Cys Leu Ser Glu Asp Met Thr Pro Asp Glu Pro 435 440 445 Asp
Val Phe Ser Asn Lys Phe Leu Asn Val Phe Met Ser Gly Gln Ser 450 455
460 Arg Ser Ser Ser Ala Glu Ser Phe Arg Leu Phe Ser Cys Val Ile Asn
465 470 475 480 Gly Glu Ser His Glu Gln Thr His Arg Ala Ile Phe Thr
Phe Val Pro 485 490 495 Arg His Glu Asp Glu Leu Val Leu Glu Val Asp
Asp Pro Leu Leu Val 500 505 510 Trp Leu Gln Ala Glu Asp Tyr Trp Tyr
Glu Tyr Tyr Asn Met Arg Thr 515 520 525 Gly Ala Arg Gly Ala Phe Pro
Ala Tyr Tyr Ala Ile Glu Val Asp Lys 530 535 540 Glu Pro Glu His Met
Ala Ala Leu Glu Lys Asn Ser Cys Val Leu Glu 545 550 555 560 Ile Ser
Phe Arg Gly Val Lys Ile Gly Val Lys Ala Gly Asp Ala Leu 565 570 575
Glu Ala Lys Gly Asn Lys His Ser His Phe Phe Gln Leu Lys Asn Ile 580
585 590 Ile Phe Cys Gly Tyr His Pro Lys Asn Asn Leu Tyr Phe Gly Phe
Ile 595 600 605 Thr Lys His Pro Met Asp His Arg Phe Ala Cys His Val
Phe Asn Ser 610 615 620 Glu Asp Ser Thr Lys Ala Leu Ala Gln Ser Val
Gly Arg Ala Phe Gln 625 630 635 640 Gln Phe Arg Lys Gln Phe Val Glu
Tyr Thr Cys Pro Ser Glu Asp Ile 645 650 655 Tyr Leu Glu 14 659 PRT
Artificial Sequence Description of Artificial Sequence Synthetic
Sequence 14 Met Ala Glu Ala Glu Ser Gly Leu Gly Gly Gly Ala Ala Asp
Pro Pro 1 5 10 15 Ala Ala Ser Pro Phe Leu Gly Glu His Ile Ala Ser
Pro Pro Asn Phe 20 25 30 Arg Phe Thr His Asp Ile Ser Leu Glu Glu
Phe Gly Asp Glu Asp Leu 35 40 45 Ser Glu Ile Thr Asp His Cys Gly
Ile Ser Leu Gln Cys Lys Asp Ile 50 55 60 Leu Ser Leu Arg Pro Pro
Arg Ala Gly Lys Leu Ser Ala Gly Ser Ser 65 70 75 80 Gly Ser Ala Leu
Ser Arg Leu Gln Ala Glu Met Leu Gln Asn Asp Leu 85 90 95 Ile Asp
Ala Ala Gly Asp Thr Gln Gly Ala Glu Asp Asp Glu Glu Glu 100 105 110
Glu Arg Asp Glu Leu Ala Ala Gln Arg Pro Gly Ser Gly Pro Pro Lys 115
120 125 Ala Glu Ser Asn Gln Thr Pro Ala Pro Arg Ser Gln Gly Gln Gly
Val 130 135 140 Gly Thr Gly Ser Gly Asp Thr Tyr Arg Trp Lys Arg Pro
Thr Thr Leu 145 150 155 160 Asn Leu Phe Tyr Gln Val Pro Arg Ser Gln
Asp Thr Leu Ala Asn Asn 165 170 175 Ser Leu Gly Lys Lys His Ser Asp
Gln Asp Arg Val Ser Arg Ser Ser 180 185 190 Ser Glu Leu Lys Thr Gly
Glu Gln Thr Pro Pro Phe Glu His Ile Cys 195 200 205 Leu Ser Asp Glu
Leu Gly Pro Gln Gly Ser Pro Val Pro Thr Gln His 210 215 220 Arg Gly
Thr Ser Thr Asp Ser Pro Cys Ile Arg Ser Ala Ala Thr Gln 225 230 235
240 Met Ala Pro Lys Ser Gly Pro Pro Ala Thr Ala Pro Gly Leu Arg Gly
245 250 255 His Ser His Arg Asp Arg Ile Met Tyr Gln Ala Asp Val Arg
Leu Glu 260 265 270 Ala Asn Glu Glu Ile Tyr Leu Thr Pro Val Gln Gln
Pro Pro Asp Pro 275 280 285 Ala Glu Pro Thr Ser Arg Phe Met Pro Pro
Thr Glu Ser Arg Met Thr 290 295 300 Val Ser Ser Asp Pro Asp Pro Ala
Ala Trp Ser Val Thr Ala Gly Arg 305 310 315 320 Pro His Pro Tyr Ile
Ser Glu Glu Asp Glu Gly Phe Asp Ala Leu Ser 325 330 335 Ser Pro Glu
Arg Ala Glu Pro Asp Gly Gly Gly Trp Arg Gly Ser Leu 340 345 350 Gly
Phe Pro Pro Pro Pro Pro Arg Ala Ser Leu Gly Ser Asp Thr Ser 355 360
365 Ala Leu Ser Tyr Asp His Val Lys Tyr Thr Leu Val Val Asp Glu Ile
370 375 380 Ala Gln Leu Glu Leu Val Ser Leu Arg Lys Cys Phe Gly Asp
Tyr Ser 385 390 395 400 Asp Glu Ser Leu Ser Ala Thr Val Tyr Asp Asn
Cys Ala Met Ala Ser 405 410 415 Ser Pro Tyr Glu Ser Ala Ile Asn Glu
Glu Tyr Glu Glu Ala Pro Gln 420 425 430 Pro Gln Pro Pro Thr Cys Leu
Ser Glu Asp Ser Arg Pro Asp Glu Pro 435 440 445 Asp Val Phe Ser Lys
Ser Phe Leu Asn Val Phe Met Ser Gly Arg Thr 450 455 460 Arg Ser Ser
Ser Ala Glu Ser Phe Gly Val Phe Ser Cys Val Ile Asn 465 470 475 480
Gly Glu Glu Trp Glu Gln Thr His Arg Ala Ile Phe Arg Tyr Val Pro 485
490 495 Arg His Glu Asp Glu Leu Glu Ala Glu Val Asp Asp Pro Leu Leu
Val 500 505 510 Glu Asp Gln Ala Glu Asp Tyr Trp Tyr Glu Ala Glu Asn
Met Arg Thr 515 520 525 Gly Ala Arg Gly Val Gly Pro Ala Tyr Tyr Ala
Ile Glu Val Thr His 530 535 540 Glu Pro Glu His Met Ala Ala Leu Ala
Ile Asn Ser Cys Val Leu Glu 545 550 555 560 Ile Ser Val Lys Gly Val
Lys Ile Gly Val Lys Ala Asp Leu Ala Leu 565 570 575 Glu Ala Lys Gly
Asn Lys Cys Met His Phe Phe Gln Leu Lys Asn Ile 580 585 590 Ser Asn
Cys Gly Tyr His Pro Lys Asn Asn Lys Gln Phe Gly Phe Ile 595 600 605
Thr Lys His Pro Ala Arg His Arg Phe Ala Cys His Val Phe Val Thr 610
615 620 Glu Asp Ser Thr Lys Ala Leu Ala Glu Val Val Gly Arg Ala Phe
Gln 625 630 635 640 Gln Phe Tyr Trp Gln Phe Val Glu Tyr Thr Cys Pro
Thr Tyr Asp Ile 645 650 655 Tyr Leu Glu 15 659 PRT Artificial
Sequence Description of Artificial Sequence Synthetic Sequence 15
Met Ala Glu Arg Ala Ser Gly Leu Gly Gly Gly Ala Ala Ser Asp Pro 1 5
10 15 Ala Ala Ser Pro Phe Leu Gly Leu Glu Ile Ala Ser Pro Pro Asn
Phe 20 25 30 Arg Leu Phe His Asp Ile Ser Leu Glu Glu Phe Glu Gly
Glu Asp Leu 35 40 45 Ser Glu Ile Thr Asp Glu His Gly Ile Ser Leu
Gln Cys Lys Asp Thr 50 55 60 Ile Ser Leu Arg Pro Pro Arg Ala Gly
Leu Lys Ser Ala Gly Ser Ser 65 70 75 80 Gly Ser Ala Gly Leu Arg Leu
Gln Ala Glu Met Leu Gln Met Met Leu 85 90 95 Ile Asp Ala Ala Gly
Asp Thr Pro Asn Ala Glu Asp Asp Glu Glu Glu 100 105 110 Glu Asp Gln
Glu Leu Ala Ala Gln Arg Pro Gly Val Arg Pro Pro Lys 115 120 125 Ala
Glu Ser Asn Gln Asp Ser Ala Pro Arg Ser Gln Gly Gln Gly Pro 130 135
140 Thr Thr Gly Ser Gly Asp Thr Tyr Arg Pro Val Arg Pro Thr Thr Leu
145 150 155 160 Asn Leu Phe Pro Trp Val Pro Arg Ser Gln Asp Thr Leu
Asn Tyr Asn 165 170 175 Ser Leu Gly Lys Lys His Ser Trp Ala Asp Arg
Val Ser Arg Ser Ser 180 185 190 Ser Pro Asp Lys Thr Gly Glu Gln Thr
Pro Pro His Phe His Ile Cys 195 200 205 Leu Ser Asp Glu Leu Pro Gly
Gln Gly Ser Pro Val Pro Thr Gln Asp 210 215 220 His Gly Thr Ser Thr
Asp Ser Pro Cys Arg Ile Ser Ala Ala Thr Gln 225 230 235 240 Met Ala
Pro Pro Lys Gly Pro Pro Ala Thr Ala Pro Gly Gly Leu Gly 245 250 255
His Ser His Arg Asp Arg Ile His Met Gln Ala Asp Val Arg Leu Glu 260
265 270 Ala Thr Asn Glu Ile Tyr Leu Thr Pro Val Gln Arg Gln Pro Asp
Pro 275 280 285 Ala Glu Pro Thr Ser Thr Arg Met Pro Pro Thr Glu Ser
Arg Met Ser 290 295 300 Ser Ser Ser Asp Pro Asp Pro Ala Ala Tyr Thr
Val Thr Ala Gly Arg 305 310 315 320 Pro His Pro Ser Val Ser Glu Glu
Asp Glu Gly Phe Asp Cys Trp Ser 325 330 335 Ser Pro Glu Arg Ala Glu
Pro Pro Tyr Gly Gly Trp Arg Gly Ser Leu 340 345 350 Gly Glu Ala Pro
Pro Pro Pro Arg Ala Ser Leu Ser Asp Asp Thr Ser 355 360 365 Ala Leu
Ser Tyr Asp Ser Glu Lys Tyr Thr Leu Val Val Asp Glu His 370 375 380
Phe Gln Leu Glu Leu Val Ser Leu Arg Pro Gly Phe Gly Asp Tyr Ser 385
390 395 400 Asp Glu Ser Asp His Ala Thr Val Tyr Asp Asn Cys Ala Ser
Ile Ser 405 410 415 Ser Pro Tyr Glu Ser Ala Ile Gly Lys Glu Tyr Glu
Glu Ala Pro Gln 420 425 430 Pro Arg Leu Pro Thr Cys Leu Ser Glu Asp
Ser Thr Met Asp Glu Pro 435 440 445 Asp Val Phe Ser Lys Lys Asn Leu
Asn Val Phe Met Ser Gly Arg Ser 450 455 460 Gln Ser Ser Ser Ala Glu
Ser Phe Gly Leu Arg Ser Cys Val Ile Asn 465 470 475 480 Gly Glu Glu
His Ser Gln Thr His Arg Ala Ile Phe Arg Phe Thr Pro 485 490 495 Arg
His Glu Asp Glu Leu Glu Leu Val Val Asp Asp Pro Leu Leu Val 500 505
510 Glu Leu Trp Ala Glu Asp Tyr Trp Tyr Glu Ala Tyr Tyr Met Arg Thr
515 520 525 Gly Ala Arg Gly Val Phe Ala Ala Tyr Tyr Ala Ile Glu Val
Thr Lys 530 535 540 Asp Pro Glu His Met Ala Ala Leu Ala Lys Glu Ser
Cys Val Leu Glu 545 550 555 560 Ile Ser Val Arg Phe Val Lys Ile Gly
Val Lys Ala Asp Asp Gly Leu 565 570 575 Glu Ala Lys Gly Asn Lys Cys
Ser Ile Phe Phe Gln Leu Lys Asn Ile 580 585 590 Ser Phe Lys Gly Tyr
His Pro Lys Asn Asn Lys Tyr Leu Gly Phe Ile 595 600 605 Thr Lys His
Pro Ala Asp Met Arg Phe Ala Cys His Val Phe Val Ser 610 615 620 Asn
Asp Ser Thr Lys Ala Leu Ala Glu Ser Gln Gly Arg Ala Phe Gln 625 630
635 640 Gln Phe Tyr Lys Arg Phe Val Glu Tyr Thr Cys Pro Thr Glu Ser
Ile 645 650 655 Tyr Leu Glu 16 659 PRT Artificial Sequence
Description of Artificial Sequence Synthetic Sequence 16 Met Ala
Glu Arg Glu Ala Gly Leu Gly Gly Gly Ala Ala Ser Pro Asp 1 5 10 15
Ala Ala Ser Pro Phe Leu Gly Leu His Glu Ala Ser Pro Pro Asn Phe 20
25 30 Arg Leu Thr Phe Asp Ile Ser Leu Glu Glu Phe Glu Asp Gly Asp
Leu 35 40 45 Ser Glu Ile Thr Asp Glu Cys His Ile Ser Leu Gln Cys
Lys Asp Thr 50 55 60 Leu Ile Leu Arg Pro Pro Arg Ala Gly Leu Leu
Lys Ala Gly Ser Ser 65 70 75 80 Gly Ser Ala Gly Ser Leu Leu Gln Ala
Glu Met Leu Gln Met Asp Met 85 90 95 Ile Asp Ala Ala Gly Asp Thr
Pro Gly Asn Glu Asp Asp Glu Glu Glu 100 105 110 Glu Asp Asp Gln Leu
Ala Ala Gln Arg Pro Gly Val Gly Arg Pro Lys 115 120 125 Ala Glu Ser
Asn Gln Asp Pro Ser Pro Arg Ser Gln Gly Gln Gly Pro 130 135 140 Gly
Val Gly Ser Gly Asp Thr Tyr Arg Pro Lys Trp Pro Thr Thr Leu 145 150
155 160 Asn Leu Phe Pro Gln Tyr Pro Arg Ser Gln Asp Thr Leu Asn Asn
Ala 165 170 175 Ser Leu Gly Lys Lys His Ser Trp Gln Asp Arg Val Ser
Arg Ser Ser 180 185 190 Ser Pro Leu Glu Thr Gly Glu Gln Thr Pro Pro
His Glu Phe Ile Cys 195 200 205 Leu Ser Asp Glu Leu Pro Pro Gly Gly
Ser Pro Val Pro Thr Gln Asp 210 215 220 Arg His Thr Ser Thr Asp Ser
Pro Cys Arg Arg Ile Ala Ala Thr Gln 225 230 235 240 Met Ala Pro Pro
Ser Lys Pro Pro Ala Thr Ala Pro Gly Gly Arg Leu 245 250 255 His Ser
His Arg Asp Arg Ile His Tyr Met Ala Asp Val Arg Leu Glu 260 265 270
Ala Thr Glu Asn Ile Tyr Leu Thr Pro Val Gln Arg Pro Gln Asp Pro 275
280 285 Ala Glu Pro Thr Ser Thr Phe Arg Pro Pro Thr Glu Ser Arg Met
Ser 290 295 300 Val Thr Ser Asp Pro Asp Pro Ala Ala Tyr Ser Trp Thr
Ala Gly Arg 305 310 315 320 Pro His Pro Ser Ile Tyr Glu Glu Asp Glu
Gly Phe Asp Cys Leu Ala 325 330 335 Ser Pro Glu Arg Ala Glu Pro Pro
Gly Asp Gly Trp Arg Gly Ser Leu 340 345 350 Gly Glu Pro Glu Pro Pro
Pro Arg Ala Ser Leu Ser Ser Phe Thr Ser 355 360 365 Ala Leu Ser Tyr
Asp Ser Val Gly Tyr Thr Leu Val Val Asp Glu His 370 375 380 Ala His
Leu Glu Leu Val Ser Leu Arg Pro Cys Ile Gly Asp Tyr Ser 385 390 395
400 Asp Glu Ser Asp Ser Lys Thr Val Tyr Asp Asn Cys Ala Ser Ala Leu
405 410 415 Ser Pro Tyr Glu Ser Ala Ile Gly Glu Met Tyr Glu Glu Ala
Pro Gln 420 425 430 Pro Arg Pro Asn Thr Cys Leu Ser Glu Asp Ser Thr
Pro Gln Glu Pro 435 440 445 Asp Val Phe Ser Lys Lys Phe Arg Asn Val
Phe Met Ser Gly Arg Ser 450 455 460 Arg Thr Ser Ser Ala Glu Ser Phe
Gly Leu Phe Val Cys Val Ile Asn 465 470 475 480 Gly Glu Glu His Glu
Trp Thr His Arg Ala Ile Phe Arg Phe Val Tyr 485 490 495 Arg His Glu
Asp Glu Leu Glu Leu Glu Ala Asp Asp Pro Leu Leu Val 500 505 510 Glu
Leu Gln Asp Glu Asp Tyr Trp Tyr Glu Ala Tyr Asn Glu Arg Thr 515 520
525
Gly Ala Arg Gly Val Phe Pro Phe Tyr Tyr Ala Ile Glu Val Thr Lys 530
535 540 Glu Gly Glu His Met Ala Ala Leu Ala Lys Asn His Cys Val Leu
Glu 545 550 555 560 Ile Ser Val Arg Gly Ile Lys Ile Gly Val Lys Ala
Asp Asp Ala Lys 565 570 575 Glu Ala Lys Gly Asn Lys Cys Ser His Leu
Phe Gln Leu Lys Asn Ile 580 585 590 Ser Phe Cys Met Tyr His Pro Lys
Asn Asn Lys Tyr Phe Asn Phe Ile 595 600 605 Thr Lys His Pro Ala Asp
His Gln Phe Ala Cys His Val Phe Val Ser 610 615 620 Glu Arg Ser Thr
Lys Ala Leu Ala Glu Ser Val Ser Arg Ala Phe Gln 625 630 635 640 Gln
Phe Tyr Lys Gln Thr Val Glu Tyr Thr Cys Pro Thr Glu Asp Val 645 650
655 Tyr Leu Glu 17 659 PRT Artificial Sequence Description of
Artificial Sequence Synthetic Sequence 17 Met Ala Glu Arg Glu Ser
Ala Leu Gly Gly Gly Ala Ala Ser Pro Pro 1 5 10 15 Asp Ala Ser Pro
Phe Leu Gly Leu His Ile Glu Ser Pro Pro Asn Phe 20 25 30 Arg Leu
Thr His Phe Ile Ser Leu Glu Glu Phe Glu Asp Glu Gly Leu 35 40 45
Ser Glu Ile Thr Asp Glu Cys Gly His Ser Leu Gln Cys Lys Asp Thr 50
55 60 Leu Ser Ile Arg Pro Pro Arg Ala Gly Leu Leu Ser Lys Gly Ser
Ser 65 70 75 80 Gly Ser Ala Gly Ser Arg Met Gln Ala Glu Met Leu Gln
Met Asp Leu 85 90 95 Asn Asp Ala Ala Gly Asp Thr Pro Gly Ala Gln
Asp Asp Glu Glu Glu 100 105 110 Glu Asp Asp Glu Arg Ala Ala Gln Arg
Pro Gly Val Gly Pro Ser Lys 115 120 125 Ala Glu Ser Asn Gln Asp Pro
Ala Thr Arg Ser Gln Gly Gln Gly Pro 130 135 140 Gly Thr Val Ser Gly
Asp Thr Tyr Arg Pro Lys Arg Trp Thr Thr Leu 145 150 155 160 Asn Leu
Phe Pro Gln Val Tyr Arg Ser Gln Asp Thr Leu Asn Asn Asn 165 170 175
Ala Leu Gly Lys Lys His Ser Trp Gln Asp Asp Val Ser Arg Ser Ser 180
185 190 Ser Pro Leu Lys Glu Gly Glu Gln Thr Pro Pro His Glu His Phe
Cys 195 200 205 Leu Ser Asp Glu Leu Pro Pro Gln His Ser Pro Val Pro
Thr Gln Asp 210 215 220 Arg Gly Ile Ser Thr Asp Ser Pro Cys Arg Arg
Ser Lys Ala Thr Gln 225 230 235 240 Met Ala Pro Pro Ser Gly Leu Pro
Ala Thr Ala Pro Gly Gly Arg Gly 245 250 255 Met Ser His Arg Asp Arg
Ile His Tyr Gln Asn Asp Val Arg Leu Glu 260 265 270 Ala Thr Glu Glu
Gln Tyr Leu Thr Pro Val Gln Arg Pro Pro Arg Pro 275 280 285 Ala Glu
Pro Thr Ser Thr Phe Met Ser Pro Thr Glu Ser Arg Met Ser 290 295 300
Val Ser Thr Asp Pro Asp Pro Ala Ala Tyr Ser Val Val Ala Gly Arg 305
310 315 320 Pro His Pro Ser Ile Ser Trp Glu Asp Glu Gly Phe Asp Cys
Leu Ser 325 330 335 Tyr Pro Glu Arg Ala Glu Pro Pro Gly Gly Ala Trp
Arg Gly Ser Leu 340 345 350 Gly Glu Pro Pro Asp Pro Pro Arg Ala Ser
Leu Ser Ser Asp Glu Ser 355 360 365 Ala Leu Ser Tyr Asp Ser Val Lys
Phe Thr Leu Val Val Asp Glu His 370 375 380 Ala Gln Gly Glu Leu Val
Ser Leu Arg Pro Cys Phe His Asp Tyr Ser 385 390 395 400 Asp Glu Ser
Asp Ser Ala Ile Val Tyr Asp Asn Cys Ala Ser Ala Ser 405 410 415 Lys
Pro Tyr Glu Ser Ala Ile Gly Glu Glu Leu Glu Glu Ala Pro Gln 420 425
430 Pro Arg Pro Pro Met Cys Leu Ser Glu Asp Ser Thr Pro Asp Asn Pro
435 440 445 Asp Val Phe Ser Lys Lys Phe Leu Gln Val Phe Met Ser Gly
Arg Ser 450 455 460 Arg Ser Arg Ser Ala Glu Ser Phe Gly Leu Phe Ser
Ser Val Ile Asn 465 470 475 480 Gly Glu Glu His Glu Gln Val His Arg
Ala Ile Phe Arg Phe Val Pro 485 490 495 Trp His Glu Asp Glu Leu Glu
Leu Glu Val Tyr Asp Pro Leu Leu Val 500 505 510 Glu Leu Gln Ala Ala
Asp Tyr Trp Tyr Glu Ala Tyr Asn Met Asp Thr 515 520 525 Gly Ala Arg
Gly Val Phe Pro Ala Glu Tyr Ala Ile Glu Val Thr Lys 530 535 540 Glu
Pro Phe His Met Ala Ala Leu Ala Lys Asn Ser Gly Val Leu Glu 545 550
555 560 Ile Ser Val Arg Gly Val His Ile Gly Val Lys Ala Asp Asp Ala
Leu 565 570 575 Ile Ala Lys Gly Asn Lys Cys Ser His Phe Lys Gln Leu
Lys Asn Ile 580 585 590 Ser Phe Cys Gly Leu His Pro Lys Asn Asn Lys
Tyr Phe Gly Met Ile 595 600 605 Thr Lys His Pro Ala Asp His Arg Asn
Ala Cys His Val Phe Val Ser 610 615 620 Glu Asp Gln Thr Lys Ala Leu
Ala Glu Ser Val Gly Ser Ala Phe Gln 625 630 635 640 Gln Phe Tyr Lys
Gln Phe Thr Glu Tyr Thr Cys Pro Thr Glu Asp Ile 645 650 655 Val Leu
Glu 18 659 PRT Artificial Sequence Description of Artificial
Sequence Synthetic Sequence 18 Met Ala Glu Arg Glu Ser Gly Ala Gly
Gly Gly Ala Ala Ser Pro Pro 1 5 10 15 Ala Asp Ser Pro Phe Leu Gly
Leu His Ile Ala Glu Pro Pro Asn Phe 20 25 30 Arg Leu Thr His Asp
Phe Ser Leu Glu Glu Phe Glu Asp Glu Asp Gly 35 40 45 Ser Glu Ile
Thr Asp Glu Cys Gly Ile His Leu Gln Cys Lys Asp Thr 50 55 60 Leu
Ser Leu Ile Pro Pro Arg Ala Gly Leu Leu Ser Ala Lys Ser Ser 65 70
75 80 Gly Ser Ala Gly Ser Arg Leu Leu Ala Glu Met Leu Gln Met Asp
Leu 85 90 95 Ile Met Ala Ala Gly Asp Thr Pro Gly Ala Glu Asn Asp
Glu Glu Glu 100 105 110 Glu Asp Asp Glu Leu Gln Ala Gln Arg Pro Gly
Val Gly Pro Pro Arg 115 120 125 Ala Glu Ser Asn Gln Asp Pro Ala Pro
Ser Ser Gln Gly Gln Gly Pro 130 135 140 Gly Thr Gly Thr Gly Asp Thr
Tyr Arg Pro Lys Arg Pro Val Thr Leu 145 150 155 160 Asn Leu Phe Pro
Gln Val Pro Trp Ser Gln Asp Thr Leu Asn Asn Asn 165 170 175 Ser Tyr
Gly Lys Lys His Ser Trp Gln Asp Arg Ala Ser Arg Ser Ser 180 185 190
Ser Pro Leu Lys Thr Asp Glu Gln Thr Pro Pro His Glu His Ile Glu 195
200 205 Leu Ser Asp Glu Leu Pro Pro Gln Gly Phe Pro Val Pro Thr Gln
Asp 210 215 220 Arg Gly Thr Gly Thr Asp Ser Pro Cys Arg Arg Ser Ala
His Thr Gln 225 230 235 240 Met Ala Pro Pro Ser Gly Pro Ile Ala Thr
Ala Pro Gly Gly Arg Gly 245 250 255 His Lys His Arg Asp Arg Ile His
Tyr Gln Ala Leu Val Arg Leu Glu 260 265 270 Ala Thr Glu Glu Ile Met
Leu Thr Pro Val Gln Arg Pro Pro Asp Asn 275 280 285 Ala Glu Pro Thr
Ser Thr Phe Met Pro Gln Thr Glu Ser Arg Met Ser 290 295 300 Val Ser
Ser Arg Pro Asp Pro Ala Ala Tyr Ser Val Thr Ser Gly Arg 305 310 315
320 Pro His Pro Ser Ile Ser Glu Thr Asp Glu Gly Phe Asp Cys Leu Ser
325 330 335 Ser Val Glu Arg Ala Glu Pro Pro Gly Gly Gly Tyr Arg Gly
Ser Leu 340 345 350 Gly Glu Pro Pro Pro Ala Pro Arg Ala Ser Leu Ser
Ser Asp Thr Asp 355 360 365 Ala Leu Ser Tyr Asp Ser Val Lys Tyr Glu
Leu Val Val Asp Glu His 370 375 380 Ala Gln Leu Phe Leu Val Ser Leu
Arg Pro Cys Phe Gly Gly Tyr Ser 385 390 395 400 Asp Glu Ser Asp Ser
Ala Thr His Tyr Asp Asn Cys Ala Ser Ala Ser 405 410 415 Ser Ile Tyr
Glu Ser Ala Ile Gly Glu Glu Tyr Lys Glu Ala Pro Gln 420 425 430 Pro
Arg Pro Pro Thr Leu Leu Ser Glu Asp Ser Thr Pro Asp Glu Met 435 440
445 Asp Val Phe Ser Lys Lys Phe Leu Asn Asn Phe Met Ser Gly Arg Ser
450 455 460 Arg Ser Ser Gln Ala Glu Ser Phe Gly Leu Phe Ser Cys Arg
Ile Asn 465 470 475 480 Gly Glu Glu His Glu Gln Thr Ser Arg Ala Ile
Phe Arg Phe Val Pro 485 490 495 Arg Thr Glu Asp Glu Leu Glu Leu Glu
Val Asp Val Pro Leu Leu Val 500 505 510 Glu Leu Gln Ala Glu Trp Tyr
Trp Tyr Glu Ala Tyr Asn Met Arg Tyr 515 520 525 Gly Ala Arg Gly Val
Phe Pro Ala Tyr Ala Ala Ile Glu Val Thr Lys 530 535 540 Glu Pro Glu
Asp Met Ala Ala Leu Ala Lys Asn Ser Cys Glu Leu Glu 545 550 555 560
Ile Ser Val Arg Gly Val Lys Phe Gly Val Lys Ala Asp Asp Ala Leu 565
570 575 Glu Gly Lys Gly Asn Lys Cys Ser His Phe Phe His Leu Lys Asn
Ile 580 585 590 Ser Phe Cys Gly Tyr Ile Pro Lys Asn Asn Lys Tyr Phe
Gly Phe Lys 595 600 605 Thr Lys His Pro Ala Asp His Arg Phe Leu Cys
His Val Phe Val Ser 610 615 620 Glu Asp Ser Met Lys Ala Leu Ala Glu
Ser Val Gly Arg Asn Phe Gln 625 630 635 640 Gln Phe Tyr Lys Gln Phe
Val Gln Tyr Thr Cys Pro Thr Glu Asp Ile 645 650 655 Tyr Arg Glu 19
659 PRT Artificial Sequence Description of Artificial Sequence
Synthetic Sequence 19 Met Ala Glu Arg Glu Ser Gly Leu Ala Gly Gly
Ala Ala Ser Pro Pro 1 5 10 15 Ala Ala Asp Pro Phe Leu Gly Leu His
Ile Ala Ser Glu Pro Asn Phe 20 25 30 Arg Leu Thr His Asp Ile Phe
Leu Glu Glu Phe Glu Asp Glu Asp Leu 35 40 45 Gly Glu Ile Thr Asp
Glu Cys Gly Ile Ser His Gln Cys Lys Asp Thr 50 55 60 Leu Ser Leu
Arg Ile Pro Arg Ala Gly Leu Leu Ser Ala Gly Lys Ser 65 70 75 80 Gly
Ser Ala Gly Ser Arg Leu Gln Leu Glu Met Leu Gln Met Asp Leu 85 90
95 Ile Asp Met Ala Gly Asp Thr Pro Gly Ala Glu Asp Asn Glu Glu Glu
100 105 110 Glu Asp Asp Glu Leu Ala Gln Gln Arg Pro Gly Val Gly Pro
Pro Lys 115 120 125 Arg Glu Ser Asn Gln Asp Pro Ala Pro Arg Thr Gln
Gly Gln Gly Pro 130 135 140 Gly Thr Gly Ser Val Asp Thr Tyr Arg Pro
Lys Arg Pro Thr Trp Leu 145 150 155 160 Asn Leu Phe Pro Gln Val Pro
Arg Tyr Gln Asp Thr Leu Asn Asn Asn 165 170 175 Ser Leu Ala Lys Lys
His Ser Trp Gln Asp Arg Val Asp Arg Ser Ser 180 185 190 Ser Pro Leu
Lys Thr Gly Phe Gln Thr Pro Pro His Glu His Ile Cys 195 200 205 Gly
Ser Asp Glu Leu Pro Pro Gln Gly Ser His Val Pro Thr Gln Asp 210 215
220 Arg Gly Thr Ser Ile Asp Ser Pro Cys Arg Arg Ser Ala Ala Lys Gln
225 230 235 240 Met Ala Pro Pro Ser Gly Pro Pro Leu Thr Ala Pro Gly
Gly Arg Gly 245 250 255 His Ser Met Arg Asp Arg Ile His Tyr Gln Ala
Asp Asn Arg Leu Glu 260 265 270 Ala Thr Glu Glu Ile Tyr Gln Thr Pro
Val Gln Arg Pro Pro Asp Pro 275 280 285 Arg Glu Pro Thr Ser Thr Phe
Met Pro Pro Ser Glu Ser Arg Met Ser 290 295 300 Val Ser Ser Asp Thr
Asp Pro Ala Ala Tyr Ser Val Thr Ala Val Arg 305 310 315 320 Pro His
Pro Ser Ile Ser Glu Glu Trp Glu Gly Phe Asp Cys Leu Ser 325 330 335
Ser Pro Tyr Arg Ala Glu Pro Pro Gly Gly Gly Trp Ala Gly Ser Leu 340
345 350 Gly Glu Pro Pro Pro Pro Asp Arg Ala Ser Leu Ser Ser Asp Thr
Ser 355 360 365 Glu Leu Ser Tyr Asp Ser Val Lys Tyr Thr Phe Val Val
Asp Glu His 370 375 380 Ala Gln Leu Glu Gly Val Ser Leu Arg Pro Cys
Phe Gly Asp His Ser 385 390 395 400 Asp Glu Ser Asp Ser Ala Thr Val
Ile Asp Asn Cys Ala Ser Ala Ser 405 410 415 Ser Pro Lys Glu Ser Ala
Ile Gly Glu Glu Tyr Glu Leu Ala Pro Gln 420 425 430 Pro Arg Pro Pro
Thr Cys Met Ser Glu Asp Ser Thr Pro Asp Glu Pro 435 440 445 Asn Val
Phe Ser Lys Lys Phe Leu Asn Val Gln Met Ser Gly Arg Ser 450 455 460
Arg Ser Ser Ser Arg Glu Ser Phe Gly Leu Phe Ser Cys Val Ser Asn 465
470 475 480 Gly Glu Glu His Glu Gln Thr His Thr Ala Ile Phe Arg Phe
Val Pro 485 490 495 Arg His Val Asp Glu Leu Glu Leu Glu Val Asp Asp
Trp Leu Leu Val 500 505 510 Glu Leu Gln Ala Glu Asp Ala Trp Tyr Glu
Ala Tyr Asn Met Arg Thr 515 520 525 Asp Ala Arg Gly Val Phe Pro Ala
Tyr Tyr Glu Ile Glu Val Thr Lys 530 535 540 Glu Pro Glu His Phe Ala
Ala Leu Ala Lys Asn Ser Cys Val Gly Glu 545 550 555 560 Ile Ser Val
Arg Gly Val Lys Ile His Val Lys Ala Asp Asp Ala Leu 565 570 575 Glu
Ala Ile Gly Asn Lys Cys Ser His Phe Phe Gln Lys Lys Asn Ile 580 585
590 Ser Phe Cys Gly Tyr His Leu Lys Asn Asn Lys Tyr Phe Gly Phe Ile
595 600 605 Met Lys His Pro Ala Asp His Arg Phe Ala Asn His Val Phe
Val Ser 610 615 620 Glu Asp Ser Thr Gln Ala Leu Ala Glu Ser Val Gly
Arg Ala Arg Gln 625 630 635 640 Gln Phe Tyr Lys Gln Phe Val Glu Ser
Thr Cys Pro Thr Glu Asp Ile 645 650 655 Tyr Leu Thr 20 659 PRT
Artificial Sequence Description of Artificial Sequence Synthetic
Sequence 20 Met Ala Glu Arg Glu Ser Gly Leu Gly Ala Gly Ala Ala Ser
Pro Pro 1 5 10 15 Ala Ala Ser Asp Phe Leu Gly Leu His Ile Ala Ser
Pro Glu Asn Phe 20 25 30 Arg Leu Thr His Asp Ile Ser Phe Glu Glu
Phe Glu Asp Glu Asp Leu 35 40 45 Ser Gly Ile Thr Asp Glu Cys Gly
Ile Ser Leu His Cys Lys Asp Thr 50 55 60 Leu Ser Leu Arg Pro Ile
Arg Ala Gly Leu Leu Ser Ala Gly Ser Lys 65 70 75 80 Gly Ser Ala Gly
Ser Arg Leu Gln Ala Leu Met Leu Gln Met Asp Leu 85 90 95 Ile Asp
Ala Met Gly Asp Thr Pro Gly Ala Glu Asp Asp Asn Glu Glu 100 105 110
Glu Asp Asp Glu Leu Ala Ala Arg Arg Pro Gly Val Gly Pro Pro Lys 115
120 125 Ala Ser Ser Asn Gln Asp Pro Ala Pro Arg Ser Thr Gly Gln Gly
Pro 130 135 140 Gly Thr Gly Ser Gly Val Thr Tyr Arg Pro Lys Arg Pro
Thr Thr Trp 145 150 155 160 Asn Leu Phe Pro Gln Val Pro Arg Ser Tyr
Asp Thr Leu Asn Asn Asn 165 170 175 Ser Leu Gly Ala Lys His Ser Trp
Gln Asp Arg Val Ser Asp Ser Ser 180 185 190 Ser Pro Leu Lys Thr Gly
Glu Glu Thr Pro Pro His Glu His Ile Cys 195 200 205 Leu Phe Asp Glu
Leu Pro Pro Gln Gly Ser Pro Gly Pro Thr Gln Asp 210 215 220 Arg Gly
Thr Ser Thr His Ser Pro Cys Arg Arg Ser Ala Ala Thr Ile 225 230 235
240 Met Ala Pro Pro Ser Gly Pro Pro Ala Lys Ala Pro Gly Gly Arg Gly
245 250 255 His Ser His Leu Asp Arg Ile His Tyr Gln Ala Asp Val Met
Leu Glu 260 265 270 Ala Thr Glu Glu Ile Tyr Leu Asn Pro Val Gln Arg
Pro Pro Asp Pro 275 280 285 Ala Gln Pro Thr Ser Thr Phe
Met Pro Pro Thr Arg Ser Arg Met Ser 290 295 300 Val Ser Ser Asp Pro
Ser Pro Ala Ala Tyr Ser Val Thr Ala Gly Thr 305 310 315 320 Pro His
Pro Ser Ile Ser Glu Glu Asp Val Gly Phe Asp Cys Leu Ser 325 330 335
Ser Pro Glu Trp Ala Glu Pro Pro Gly Gly Gly Trp Arg Tyr Ser Leu 340
345 350 Gly Glu Pro Pro Pro Pro Pro Ala Ala Ser Leu Ser Ser Asp Thr
Ser 355 360 365 Ala Asp Ser Tyr Asp Ser Val Lys Tyr Thr Leu Glu Val
Asp Glu His 370 375 380 Ala Gln Leu Glu Leu Phe Ser Leu Arg Pro Cys
Phe Gly Asp Tyr Gly 385 390 395 400 Asp Glu Ser Asp Ser Ala Thr Val
Tyr His Asn Cys Ala Ser Ala Ser 405 410 415 Ser Pro Tyr Ile Ser Ala
Ile Gly Glu Glu Tyr Glu Glu Lys Pro Gln 420 425 430 Pro Arg Pro Pro
Thr Cys Leu Leu Glu Asp Ser Thr Pro Asp Glu Pro 435 440 445 Asp Met
Phe Ser Lys Lys Phe Leu Asn Val Phe Asn Ser Gly Arg Ser 450 455 460
Arg Ser Ser Ser Ala Gln Ser Phe Gly Leu Phe Ser Cys Val Ile Arg 465
470 475 480 Gly Glu Glu His Glu Gln Thr His Arg Ser Ile Phe Arg Phe
Val Pro 485 490 495 Arg His Glu Thr Glu Leu Glu Leu Glu Val Asp Asp
Pro Val Leu Val 500 505 510 Glu Leu Gln Ala Glu Asp Tyr Tyr Tyr Glu
Ala Tyr Asn Met Arg Thr 515 520 525 Gly Asp Arg Gly Val Phe Pro Ala
Tyr Tyr Ala Glu Glu Val Thr Lys 530 535 540 Glu Pro Glu His Met Phe
Ala Leu Ala Lys Asn Ser Cys Val Leu Gly 545 550 555 560 Ile Ser Val
Arg Gly Val Lys Ile Gly His Lys Ala Asp Asp Ala Leu 565 570 575 Glu
Ala Lys Ile Asn Lys Cys Ser His Phe Phe Gln Leu Leu Asn Ile 580 585
590 Ser Phe Cys Gly Tyr His Pro Met Asn Asn Lys Tyr Phe Gly Phe Ile
595 600 605 Thr Asn His Pro Ala Asp His Arg Phe Ala Cys Gln Val Phe
Val Ser 610 615 620 Glu Asp Ser Thr Lys Arg Leu Ala Glu Ser Val Gly
Arg Ala Phe Ser 625 630 635 640 Gln Phe Tyr Lys Gln Phe Val Glu Tyr
Val Cys Pro Thr Glu Asp Ile 645 650 655 Tyr Leu Glu 21 724 PRT
Artificial Sequence Description of Artificial Sequence Synthetic
Sequence 21 Met Asp Cys Leu Cys Ile Val Thr Thr Lys Lys Tyr Arg Tyr
Gln Asp 1 5 10 15 Glu Asp Thr Pro Pro Leu Glu His Ser Pro Ala His
Leu Pro Asn Gln 20 25 30 Ala Asn Ser Pro Pro Val Ile Val Asn Thr
Asp Thr Leu Glu Ala Pro 35 40 45 Gly Tyr Glu Leu Gln Val Asn Gly
Thr Glu Gly Glu Met Glu Tyr Glu 50 55 60 Glu Ile Thr Leu Glu Arg
Gly Asn Ser Gly Leu Gly Phe Ser Ile Ala 65 70 75 80 Gly Gly Thr Asp
Asn Pro His Ile Gly Asp Asp Pro Ser Ile Phe Ile 85 90 95 Thr Lys
Ile Ile Pro Gly Gly Ala Ala Ala Gln Asp Gly Arg Leu Arg 100 105 110
Val Asn Asp Ser Ile Leu Phe Val Asn Glu Val Asp Val Arg Glu Val 115
120 125 Thr His Ser Ala Ala Val Glu Ala Leu Lys Glu Ala Gly Ser Ile
Val 130 135 140 Arg Leu Tyr Val Met Arg Arg Lys Pro Pro Ala Glu Lys
Ile Ile Glu 145 150 155 160 Ile Lys Leu Ile Lys Gly Pro Lys Gly Leu
Gly Phe Ser Ile Ala Gly 165 170 175 Gly Val Gly Asn Gln His Ile Pro
Gly Asp Asn Ser Ile Tyr Val Thr 180 185 190 Lys Ile Ile Glu Gly Gly
Ala Ala His Lys Asp Gly Arg Leu Gln Ile 195 200 205 Gly Asp Lys Ile
Leu Ala Val Asn Ser Val Gly Leu Glu Asp Val Met 210 215 220 His Glu
Asp Ala Val Ala Ala Leu Lys Asn Thr Tyr Asp Val Val Tyr 225 230 235
240 Leu Lys Val Ala Lys Pro Ser Asn Ala Tyr Leu Ser Asp Ser Tyr Ala
245 250 255 Pro Pro Asp Ile Thr Thr Ser Tyr Ser Gln His Leu Asp Asn
Glu Ile 260 265 270 Ser His Ser Ser Tyr Leu Gly Thr Asp Tyr Pro Thr
Ala Met Thr Pro 275 280 285 Thr Ser Pro Arg Arg Tyr Ser Pro Val Ala
Lys Asp Leu Leu Gly Glu 290 295 300 Glu Asp Ile Pro Arg Glu Pro Arg
Arg Ile Val Ile His Arg Gly Ser 305 310 315 320 Thr Gly Leu Gly Phe
Asn Ile Val Gly Gly Glu Asp Gly Glu Gly Ile 325 330 335 Phe Ile Ser
Phe Ile Leu Ala Gly Gly Pro Ala Asp Leu Ser Gly Glu 340 345 350 Leu
Arg Lys Gly Asp Gln Ile Leu Ser Val Asn Gly Val Asp Leu Arg 355 360
365 Asn Ala Ser His Glu Gln Ala Ala Ile Ala Leu Lys Asn Ala Gly Gln
370 375 380 Thr Val Thr Ile Ile Ala Gln Tyr Lys Pro Glu Glu Tyr Ser
Arg Phe 385 390 395 400 Glu Ala Lys Ile His Asp Leu Arg Glu Gln Leu
Met Asn Ser Ser Leu 405 410 415 Gly Ser Gly Thr Ala Ser Leu Arg Ser
Asn Pro Lys Arg Gly Phe Tyr 420 425 430 Ile Arg Ala Leu Phe Asp Tyr
Asp Lys Thr Lys Asp Cys Gly Phe Leu 435 440 445 Ser Gln Ala Leu Ser
Phe His Phe Gly Asp Val Leu His Val Ile Asp 450 455 460 Ala Ser Asp
Glu Glu Trp Trp Gln Ala Arg Arg Val His Ser Asp Ser 465 470 475 480
Glu Thr Asp Asp Ile Gly Phe Ile Pro Ser Lys Arg Arg Val Glu Arg 485
490 495 Arg Glu Trp Ser Arg Leu Lys Ala Lys Asp Trp Gly Ser Ser Ser
Gly 500 505 510 Ser Gln Gly Arg Glu Asp Ser Val Leu Ser Tyr Glu Thr
Val Thr Gln 515 520 525 Met Glu Val His Tyr Ala Arg Pro Ile Ile Ile
Leu Gly Pro Thr Lys 530 535 540 Asp Arg Ala Asn Asp Asp Leu Leu Ser
Glu Phe Pro Asp Lys Phe Gly 545 550 555 560 Ser Cys Val Pro His Thr
Thr Arg Pro Lys Arg Glu Tyr Glu Ile Asp 565 570 575 Gly Arg Asp Tyr
His Phe Val Ser Ser Arg Glu Lys Met Glu Lys Asp 580 585 590 Ile Gln
Ala His Lys Phe Ile Glu Ala Gly Gln Tyr Asn Ser His Leu 595 600 605
Tyr Gly Thr Ser Val Gln Ser Val Arg Glu Val Ala Glu Gln Gly Lys 610
615 620 His Cys Ile Leu Asp Val Ser Ala Asn Ala Val Arg Arg Leu Gln
Ala 625 630 635 640 Ala His Leu His Pro Ile Ala Ile Phe Ile Arg Pro
Arg Ser Leu Glu 645 650 655 Asn Val Leu Glu Ile Asn Lys Arg Ile Thr
Glu Glu Gln Ala Arg Lys 660 665 670 Ala Phe Asp Arg Ala Thr Lys Leu
Glu Gln Glu Phe Thr Glu Cys Phe 675 680 685 Ser Ala Ile Val Glu Gly
Asp Ser Phe Glu Glu Ile Tyr His Lys Val 690 695 700 Lys Arg Val Ile
Glu Asp Leu Ser Gly Pro Tyr Ile Trp Val Pro Ala 705 710 715 720 Arg
Glu Arg Leu 22 724 PRT Artificial Sequence Description of
Artificial Sequence Synthetic Sequence 22 Met Ala Cys Leu Cys Ile
Val Thr Thr Lys Lys Asp Arg Tyr Gln Asp 1 5 10 15 Glu Asp Thr Pro
Pro Glu Glu His Ser Pro Ala His Leu Pro Asn Phe 20 25 30 Ala Asn
Ser Pro Pro Val Ile Val Asn Gly Asp Thr Leu Glu Ala Pro 35 40 45
Gly Tyr Glu His Gln Val Asn Gly Thr Glu Gly Glu Met Ile Tyr Glu 50
55 60 Glu Ile Thr Leu Glu Arg Gly Lys Ser Gly Leu Gly Phe Ser Ile
Ala 65 70 75 80 Gly Leu Thr Asp Asn Pro His Ile Gly Asp Asp Met Ser
Ile Phe Ile 85 90 95 Thr Lys Ile Ile Pro Asn Gly Ala Ala Ala Gln
Asp Gly Arg Leu Gln 100 105 110 Val Asn Asp Ser Ile Leu Phe Val Asn
Arg Val Asp Val Arg Glu Val 115 120 125 Thr His Ser Ser Ala Val Glu
Ala Leu Lys Glu Ala Gly Thr Ile Val 130 135 140 Arg Leu Tyr Val Met
Arg Arg Val Pro Pro Ala Glu Lys Ile Ile Glu 145 150 155 160 Ile Trp
Leu Ile Lys Gly Pro Lys Gly Leu Gly Tyr Ser Ile Ala Gly 165 170 175
Gly Val Gly Asn Gln Ala Ile Pro Gly Asp Asn Ser Ile Tyr Val Asp 180
185 190 Lys Ile Ile Glu Gly Gly Ala Ala His Glu Asp Gly Arg Leu Gln
Ile 195 200 205 Gly Asp Lys Phe Leu Ala Val Asn Ser Val Gly Leu Glu
Gly Val Met 210 215 220 His Glu Asp Ala Val Ala Ala His Lys Asn Thr
Tyr Asp Val Val Tyr 225 230 235 240 Leu Ile Val Ala Lys Pro Ser Asn
Ala Tyr Leu Lys Asp Ser Tyr Ala 245 250 255 Pro Pro Asp Ile Thr Leu
Ser Tyr Ser Gln His Leu Asp Asn Glu Met 260 265 270 Ser His Ser Ser
Tyr Leu Gly Thr Asp Asn Pro Thr Ala Met Thr Pro 275 280 285 Thr Ser
Pro Gln Arg Tyr Ser Pro Val Ala Lys Asp Leu Arg Gly Glu 290 295 300
Glu Asp Ile Pro Arg Glu Pro Ser Arg Ile Val Ile His Arg Gly Ser 305
310 315 320 Thr Thr Leu Gly Phe Asn Ile Val Gly Gly Glu Val Gly Glu
Gly Ile 325 330 335 Phe Ile Ser Phe Ile Trp Ala Gly Gly Pro Ala Asp
Leu Ser Gly Tyr 340 345 350 Leu Arg Lys Gly Asp Gln Ile Leu Ser Ala
Asn Gly Val Asp Leu Arg 355 360 365 Asn Ala Ser Asp Glu Gln Ala Ala
Ile Ala Leu Lys Asn Glu Gly Gln 370 375 380 Thr Val Thr Ile Ile Ala
Gln Phe Lys Pro Glu Glu Tyr Ser Arg Phe 385 390 395 400 Glu Gly Lys
Ile His Asp Leu Arg Glu Gln Leu His Asn Ser Ser Leu 405 410 415 Gly
Ser Gly Thr Ala Ile Leu Arg Ser Asn Pro Lys Arg Gly Phe Lys 420 425
430 Ile Arg Ala Leu Phe Asp Tyr Asp Lys Leu Lys Asp Cys Gly Phe Leu
435 440 445 Ser Gln Ala Met Ser Phe His Phe Gly Asp Val Leu His Asn
Ile Asp 450 455 460 Ala Ser Asp Glu Glu Trp Trp Arg Ala Arg Arg Val
His Ser Asp Ser 465 470 475 480 Glu Ser Asp Asp Ile Gly Phe Ile Pro
Ser Lys Thr Arg Val Glu Arg 485 490 495 Arg Glu Trp Ser Arg Val Lys
Ala Lys Asp Trp Gly Ser Ser Ser Trp 500 505 510 Ser Gln Gly Arg Glu
Asp Ser Val Leu Tyr Tyr Glu Thr Val Thr Gln 515 520 525 Met Glu Val
Ala Tyr Ala Arg Pro Ile Ile Ile Leu Gly Asp Thr Lys 530 535 540 Asp
Arg Ala Asn Asp Asp Leu Glu Ser Glu Phe Pro Asp Lys Phe Gly 545 550
555 560 Ser Phe Val Pro His Thr Thr Arg Pro Lys Arg Gly Tyr Glu Ile
Asp 565 570 575 Gly Arg Asp Tyr His His Val Ser Ser Arg Glu Lys Met
Glu Lys Ile 580 585 590 Ile Gln Ala His Lys Phe Ile Glu Ala Lys Gln
Tyr Asn Ser His Leu 595 600 605 Tyr Gly Thr Leu Val Gln Ser Val Arg
Glu Val Ala Glu Met Gly Lys 610 615 620 His Cys Ile Leu Asp Val Ser
Asn Asn Ala Val Arg Arg Leu Gln Ala 625 630 635 640 Ala Gln Leu His
Pro Ile Ala Ile Phe Ile Arg Arg Arg Ser Leu Glu 645 650 655 Asn Val
Leu Glu Ile Ser Lys Arg Ile Thr Glu Glu Gln Ala Arg Thr 660 665 670
Ala Phe Asp Arg Ala Thr Lys Leu Glu Val Glu Phe Thr Glu Cys Phe 675
680 685 Ser Ala Ile Trp Glu Gly Asp Ser Phe Glu Glu Ile Tyr Tyr Lys
Val 690 695 700 Lys Arg Val Ile Glu Asp Leu Ala Gly Pro Tyr Ile Trp
Val Pro Ala 705 710 715 720 Arg Asp Arg Leu 23 724 PRT Artificial
Sequence Description of Artificial Sequence Synthetic Sequence 23
Met Asp Ala Leu Cys Ile Val Thr Thr Lys Lys Tyr Asp Tyr Gln Asp 1 5
10 15 Glu Asp Thr Pro Pro Leu Phe His Ser Pro Ala His Leu Pro Asn
Gln 20 25 30 Gly Asn Ser Pro Pro Val Ile Val Asn Thr His Thr Leu
Glu Ala Pro 35 40 45 Gly Tyr Glu Leu Ile Val Asn Gly Thr Glu Gly
Glu Met Glu Lys Glu 50 55 60 Glu Ile Thr Leu Glu Arg Gly Asn Leu
Gly Leu Gly Phe Ser Ile Ala 65 70 75 80 Gly Gly Met Asp Asn Pro His
Ile Gly Asp Asp Pro Asn Ile Phe Ile 85 90 95 Thr Lys Ile Ile Pro
Gly Gln Ala Ala Ala Gln Asp Gly Arg Leu Arg 100 105 110 Arg Asn Asp
Ser Ile Leu Phe Val Asn Glu Ser Asp Val Arg Glu Val 115 120 125 Thr
His Ser Ala Thr Val Glu Ala Leu Lys Glu Ala Gly Ser Val Val 130 135
140 Arg Leu Tyr Val Met Arg Arg Lys Trp Pro Ala Glu Lys Ile Ile Glu
145 150 155 160 Ile Lys Tyr Ile Lys Gly Pro Lys Gly Leu Gly Phe Ala
Ile Ala Gly 165 170 175 Gly Val Gly Asn Gln His Asp Pro Gly Asp Asn
Ser Ile Tyr Val Thr 180 185 190 Glu Ile Ile Glu Gly Gly Ala Ala His
Lys Phe Gly Arg Leu Gln Ile 195 200 205 Gly Asp Lys Ile Gly Ala Val
Asn Ser Val Gly Leu Glu Asp His Met 210 215 220 His Glu Asp Ala Val
Ala Ala Leu Ile Asn Thr Tyr Asp Val Val Tyr 225 230 235 240 Leu Lys
Lys Ala Lys Pro Ser Asn Ala Tyr Leu Ser Leu Ser Tyr Ala 245 250 255
Pro Pro Asp Ile Thr Thr Met Tyr Ser Gln His Leu Asp Asn Glu Ile 260
265 270 Asn His Ser Ser Tyr Leu Gly Thr Asp Tyr Gln Thr Ala Met Thr
Pro 275 280 285 Thr Ser Pro Arg Ser Tyr Ser Pro Val Ala Lys Asp Leu
Leu Thr Glu 290 295 300 Glu Asp Ile Pro Arg Glu Pro Arg Val Ile Val
Ile His Arg Gly Ser 305 310 315 320 Thr Gly Trp Gly Phe Asn Ile Val
Gly Gly Glu Asp Tyr Glu Gly Ile 325 330 335 Phe Ile Ser Phe Ile Leu
Asp Gly Gly Pro Ala Asp Leu Ser Gly Glu 340 345 350 Glu Arg Lys Gly
Asp Gln Ile Leu Ser Val Phe Gly Val Asp Leu Arg 355 360 365 Asn Ala
Ser His Gly Gln Ala Ala Ile Ala Leu Lys Asn Ala His Gln 370 375 380
Thr Val Thr Ile Ile Ala Gln Tyr Ile Pro Glu Glu Tyr Ser Arg Phe 385
390 395 400 Glu Ala Leu Ile His Asp Leu Arg Glu Gln Leu Met Met Ser
Ser Leu 405 410 415 Gly Ser Gly Thr Ala Ser Asn Arg Ser Asn Pro Lys
Arg Gly Phe Tyr 420 425 430 Gln Arg Ala Leu Phe Asp Tyr Asp Lys Thr
Arg Asp Cys Gly Phe Leu 435 440 445 Ser Gln Ala Leu Thr Phe His Phe
Gly Asp Val Leu His Val Val Asp 450 455 460 Ala Ser Asp Glu Glu Trp
Trp Gln Trp Arg Arg Val His Ser Asp Ser 465 470 475 480 Glu Thr Tyr
Asp Ile Gly Phe Ile Pro Ser Lys Arg Ala Val Glu Arg 485 490 495 Arg
Glu Trp Ser Arg Leu Asp Ala Lys Asp Trp Gly Ser Ser Ser Gly 500 505
510 Glu Gln Gly Arg Glu Asp Ser Val Leu Ser Phe Glu Thr Val Thr Gln
515 520 525 Met Glu Val His Gly Ala Arg Pro Ile Ile Ile Leu Gly Pro
His Lys 530 535 540 Asp Arg Ala Asn Asp Asp Leu Leu Ile Glu Phe Pro
Asp Lys Phe Gly 545 550 555 560 Ser Cys Lys Pro His Thr Thr Arg Pro
Lys Arg Glu Leu Glu Ile Asp 565 570 575 Gly Arg Asp Tyr His Phe Met
Ser Ser Arg Glu Lys Met Glu Lys Asp 580 585 590 Asn Gln Ala His Lys
Phe Ile Glu Ala Gly Arg Tyr Asn Ser
His Leu 595 600 605 Tyr Gly Thr Ser Ser Gln Ser Val Arg Glu Val Ala
Glu Gln Thr Lys 610 615 620 His Cys Ile Leu Asp Val Ser Ala Val Ala
Val Arg Arg Leu Gln Ala 625 630 635 640 Ala His Trp His Pro Ile Ala
Ile Phe Ile Arg Pro Tyr Ser Leu Glu 645 650 655 Asn Val Leu Glu Ile
Asn Ala Arg Ile Thr Glu Glu Gln Ala Arg Lys 660 665 670 Asp Phe Asp
Arg Ala Thr Lys Leu Glu Gln Phe Phe Thr Glu Cys Phe 675 680 685 Ser
Ala Ile Val Gly Gly Asp Ser Phe Glu Glu Ile Tyr His His Val 690 695
700 Lys Arg Val Ile Glu Asp Leu Ser Ile Pro Tyr Ile Trp Val Pro Ala
705 710 715 720 Arg Glu Lys Leu 24 724 PRT Artificial Sequence
Description of Artificial Sequence Synthetic Sequence 24 Met Asp
Cys Ala Cys Ile Val Thr Thr Lys Lys Tyr Arg Asp Gln Asp 1 5 10 15
Glu Asp Thr Pro Pro Leu Glu Glu Ser Pro Ala His Leu Pro Asn Gln 20
25 30 Ala Phe Ser Pro Pro Val Ile Val Asn Thr Asp Gly Leu Glu Ala
Pro 35 40 45 Gly Tyr Glu Leu Gln His Asn Gly Thr Glu Gly Glu Met
Glu Tyr Ile 50 55 60 Glu Ile Thr Leu Glu Arg Gly Asn Ser Lys Leu
Gly Phe Ser Ile Ala 65 70 75 80 Gly Gly Thr Leu Asn Pro His Ile Gly
Asp Asp Pro Ser Met Phe Ile 85 90 95 Thr Lys Ile Ile Pro Gly Gly
Asn Ala Ala Gln Asp Gly Arg Leu Arg 100 105 110 Val Gln Asp Ser Ile
Leu Phe Val Asn Glu Val Arg Val Arg Glu Val 115 120 125 Thr His Ser
Ala Ala Ser Glu Ala Leu Lys Glu Ala Gly Ser Ile Thr 130 135 140 Arg
Leu Tyr Val Met Arg Arg Lys Pro Val Ala Glu Lys Ile Ile Glu 145 150
155 160 Ile Lys Leu Trp Lys Gly Pro Lys Gly Leu Gly Phe Ser Tyr Ala
Gly 165 170 175 Gly Val Gly Asn Gln His Ile Ala Gly Asp Asn Ser Ile
Tyr Val Thr 180 185 190 Lys Asp Ile Glu Gly Gly Ala Ala His Lys Asp
Glu Arg Leu Gln Ile 195 200 205 Gly Asp Lys Ile Leu Phe Val Asn Ser
Val Gly Leu Glu Asp Val Gly 210 215 220 His Glu Asp Ala Val Ala Ala
Leu Lys His Thr Tyr Asp Val Val Tyr 225 230 235 240 Leu Lys Val Ile
Lys Pro Ser Asn Ala Tyr Leu Ser Asp Lys Tyr Ala 245 250 255 Pro Pro
Asp Ile Thr Thr Ser Leu Ser Gln His Leu Asp Asn Glu Ile 260 265 270
Ser Met Ser Ser Tyr Leu Gly Thr Asp Tyr Pro Asn Ala Met Thr Pro 275
280 285 Thr Ser Pro Arg Arg Gln Ser Pro Val Ala Lys Asp Leu Leu Gly
Arg 290 295 300 Glu Asp Ile Pro Arg Glu Pro Arg Arg Ser Val Ile His
Arg Gly Ser 305 310 315 320 Thr Gly Leu Thr Phe Asn Ile Val Gly Gly
Glu Asp Gly Val Gly Ile 325 330 335 Phe Ile Ser Phe Ile Leu Ala Trp
Gly Pro Ala Asp Leu Ser Gly Glu 340 345 350 Leu Tyr Lys Gly Asp Gln
Ile Leu Ser Val Asn Ala Val Asp Leu Arg 355 360 365 Asn Ala Ser His
Glu Asp Ala Ala Ile Ala Leu Lys Asn Ala Gly Glu 370 375 380 Thr Val
Thr Ile Ile Ala Gln Tyr Lys Phe Glu Glu Tyr Ser Arg Phe 385 390 395
400 Glu Ala Lys Gly His Asp Leu Arg Glu Gln Leu Met Asn His Ser Leu
405 410 415 Gly Ser Gly Thr Ala Ser Leu Ile Ser Asn Pro Lys Arg Gly
Phe Tyr 420 425 430 Ile Lys Ala Leu Phe Asp Tyr Asp Lys Thr Lys Leu
Cys Gly Phe Leu 435 440 445 Ser Gln Ala Leu Ser Met His Phe Gly Asp
Val Leu His Val Ile Asn 450 455 460 Ala Ser Asp Glu Glu Trp Trp Gln
Ala Gln Arg Val His Ser Asp Ser 465 470 475 480 Glu Thr Asp Arg Ile
Gly Phe Ile Pro Ser Lys Arg Arg Ser Glu Arg 485 490 495 Arg Glu Trp
Ser Arg Leu Lys Thr Lys Asp Trp Gly Ser Ser Ser Gly 500 505 510 Ser
Val Gly Arg Glu Asp Ser Val Leu Ser Tyr Trp Thr Val Thr Gln 515 520
525 Met Glu Val His Tyr Tyr Arg Pro Ile Ile Ile Leu Gly Pro Thr Ala
530 535 540 Asp Arg Ala Asn Asp Asp Leu Leu Ser Asp Phe Pro Asp Lys
Phe Gly 545 550 555 560 Ser Cys Val Glu His Thr Thr Arg Pro Lys Arg
Glu Tyr Phe Ile Asp 565 570 575 Gly Arg Asp Tyr His Phe Val Gly Ser
Arg Glu Lys Met Glu Lys Asp 580 585 590 Ile His Ala His Lys Phe Ile
Glu Ala Gly Gln Ile Asn Ser His Leu 595 600 605 Tyr Gly Thr Ser Val
Lys Ser Val Arg Glu Val Ala Glu Gln Gly Leu 610 615 620 His Cys Ile
Leu Asp Val Ser Ala Asn Met Val Arg Arg Leu Gln Ala 625 630 635 640
Ala His Leu Asn Pro Ile Ala Ile Phe Ile Arg Pro Arg Gln Leu Glu 645
650 655 Asn Val Leu Glu Ile Asn Lys Ser Ile Thr Glu Glu Gln Ala Arg
Lys 660 665 670 Ala Thr Asp Arg Ala Thr Lys Leu Glu Gln Glu Val Thr
Glu Cys Phe 675 680 685 Ser Ala Ile Val Glu Trp Asp Ser Phe Glu Glu
Ile Tyr His Lys Tyr 690 695 700 Lys Arg Val Ile Glu Asp Leu Ser Gly
Ala Tyr Ile Trp Val Pro Ala 705 710 715 720 Arg Glu Arg Asp 25 724
PRT Artificial Sequence Description of Artificial Sequence
Synthetic Sequence 25 Met Asp Cys Leu Ala Ile Val Thr Thr Lys Lys
Tyr Arg Tyr Asp Asp 1 5 10 15 Glu Asp Thr Pro Pro Leu Glu His Glu
Pro Ala His Leu Pro Asn Gln 20 25 30 Ala Asn Phe Pro Pro Val Ile
Val Asn Thr Asp Thr Gly Glu Ala Pro 35 40 45 Gly Tyr Glu Leu Gln
Val His Gly Thr Glu Gly Glu Met Glu Tyr Glu 50 55 60 Ile Ile Thr
Leu Glu Arg Gly Asn Ser Gly Lys Gly Phe Ser Ile Ala 65 70 75 80 Gly
Gly Thr Asp Leu Pro His Ile Gly Asp Asp Pro Ser Ile Met Ile 85 90
95 Thr Lys Ile Ile Pro Gly Gly Ala Asn Ala Gln Asp Gly Arg Leu Arg
100 105 110 Val Asn Gln Ser Ile Leu Phe Val Asn Glu Val Asp Arg Arg
Glu Val 115 120 125 Thr His Ser Ala Ala Val Ser Ala Leu Lys Glu Ala
Gly Ser Ile Val 130 135 140 Thr Leu Tyr Val Met Arg Arg Lys Pro Pro
Val Glu Lys Ile Ile Glu 145 150 155 160 Ile Lys Leu Ile Trp Gly Pro
Lys Gly Leu Gly Phe Ser Ile Tyr Gly 165 170 175 Gly Val Gly Asn Gln
His Ile Pro Ala Asp Asn Ser Ile Tyr Val Thr 180 185 190 Lys Ile Asp
Glu Gly Gly Ala Ala His Lys Asp Gly Glu Leu Gln Ile 195 200 205 Gly
Asp Lys Ile Leu Ala Phe Asn Ser Val Gly Leu Glu Asp Val Met 210 215
220 Gly Glu Asp Ala Val Ala Ala Leu Lys Asn His Tyr Asp Val Val Tyr
225 230 235 240 Leu Lys Val Ala Ile Pro Ser Asn Ala Tyr Leu Ser Asp
Ser Lys Ala 245 250 255 Pro Pro Asp Ile Thr Thr Ser Tyr Leu Gln His
Leu Asp Asn Glu Ile 260 265 270 Ser His Met Ser Tyr Leu Gly Thr Asp
Tyr Pro Thr Asn Met Thr Pro 275 280 285 Thr Ser Pro Arg Arg Tyr Gln
Pro Val Ala Lys Asp Leu Leu Gly Glu 290 295 300 Arg Asp Ile Pro Arg
Glu Pro Arg Arg Ile Ser Ile His Arg Gly Ser 305 310 315 320 Thr Gly
Leu Gly Thr Asn Ile Val Gly Gly Glu Asp Gly Glu Val Ile 325 330 335
Phe Ile Ser Phe Ile Leu Ala Gly Trp Pro Ala Asp Leu Ser Gly Glu 340
345 350 Leu Arg Tyr Gly Asp Gln Ile Leu Ser Val Asn Gly Ala Asp Leu
Arg 355 360 365 Asn Ala Ser His Glu Gln Asp Ala Ile Ala Leu Lys Asn
Ala Gly Gln 370 375 380 Glu Val Thr Ile Ile Ala Gln Tyr Lys Pro Phe
Glu Tyr Ser Arg Phe 385 390 395 400 Glu Ala Lys Ile Gly Asp Leu Arg
Glu Gln Leu Met Asn Ser His Leu 405 410 415 Gly Ser Gly Thr Ala Ser
Leu Arg Ile Asn Pro Lys Arg Gly Phe Tyr 420 425 430 Ile Arg Lys Leu
Phe Asp Tyr Asp Lys Thr Lys Asp Leu Gly Phe Leu 435 440 445 Ser Gln
Ala Leu Ser Phe Met Phe Gly Asp Val Leu His Val Ile Asp 450 455 460
Asn Ser Asp Glu Glu Trp Trp Gln Ala Arg Gln Val His Ser Asp Ser 465
470 475 480 Glu Thr Asp Asp Arg Gly Phe Ile Pro Ser Lys Arg Arg Val
Ser Arg 485 490 495 Arg Glu Trp Ser Arg Leu Lys Ala Thr Asp Trp Gly
Ser Ser Ser Gly 500 505 510 Ser Gln Val Arg Glu Asp Ser Val Leu Ser
Tyr Glu Trp Val Thr Gln 515 520 525 Met Glu Val His Tyr Ala Tyr Pro
Ile Ile Ile Leu Gly Pro Thr Lys 530 535 540 Ala Arg Ala Asn Asp Asp
Leu Leu Ser Glu Asp Pro Asp Lys Phe Gly 545 550 555 560 Ser Cys Val
Pro Glu Thr Thr Arg Pro Lys Arg Glu Tyr Glu Phe Asp 565 570 575 Gly
Arg Asp Tyr His Phe Val Ser Gly Arg Glu Lys Met Glu Lys Asp 580 585
590 Ile Gln His His Lys Phe Ile Glu Ala Gly Gln Tyr Ile Ser His Leu
595 600 605 Tyr Gly Thr Ser Val Gln Lys Val Arg Glu Val Ala Glu Gln
Gly Lys 610 615 620 Leu Cys Ile Leu Asp Val Ser Ala Asn Ala Met Arg
Arg Leu Gln Ala 625 630 635 640 Ala His Leu His Asn Ile Ala Ile Phe
Ile Arg Pro Arg Ser Gln Glu 645 650 655 Asn Val Leu Glu Ile Asn Lys
Arg Arg Thr Glu Glu Gln Ala Arg Lys 660 665 670 Ala Phe Ser Arg Ala
Thr Lys Leu Glu Gln Glu Phe Thr Glu Cys Phe 675 680 685 Ser Ala Ile
Val Glu Gly Val Ser Phe Glu Glu Ile Tyr His Lys Val 690 695 700 Trp
Arg Val Ile Glu Asp Leu Ser Gly Pro Ala Ile Trp Val Pro Ala 705 710
715 720 Arg Glu Arg Leu 26 724 PRT Artificial Sequence Description
of Artificial Sequence Synthetic Sequence 26 Met Asp Cys Leu Cys
Ala Val Thr Thr Lys Lys Tyr Arg Tyr Gln Asp 1 5 10 15 Glu Asp Thr
Pro Pro Leu Glu His Ser Glu Ala His Leu Pro Asn Gln 20 25 30 Ala
Asn Ser Phe Pro Val Ile Val Asn Thr Asp Thr Leu Gly Ala Pro 35 40
45 Gly Tyr Glu Leu Gln Val Asn His Thr Glu Gly Glu Met Glu Tyr Glu
50 55 60 Glu Lys Thr Leu Glu Arg Gly Asn Ser Gly Leu Leu Phe Ser
Ile Ala 65 70 75 80 Gly Gly Thr Asp Asn Met His Ile Gly Asp Asp Pro
Ser Ile Phe Asn 85 90 95 Thr Lys Ile Ile Pro Gly Gly Ala Ala Gln
Gln Asp Gly Arg Leu Arg 100 105 110 Val Asn Asp Arg Ile Leu Phe Val
Asn Glu Val Asp Val Ser Glu Val 115 120 125 Thr His Ser Ala Ala Val
Glu Thr Leu Lys Glu Ala Gly Ser Ile Val 130 135 140 Arg Val Tyr Val
Met Arg Arg Lys Pro Pro Ala Trp Lys Ile Ile Glu 145 150 155 160 Ile
Lys Leu Ile Lys Tyr Pro Lys Gly Leu Gly Phe Ser Ile Ala Ala 165 170
175 Gly Val Gly Asn Gln His Ile Pro Gly Glu Asn Ser Ile Tyr Val Thr
180 185 190 Lys Ile Ile Phe Gly Gly Ala Ala His Lys Asp Gly Arg Gly
Gln Ile 195 200 205 Gly Asp Lys Ile Leu Ala Val His Ser Val Gly Leu
Glu Asp Val Met 210 215 220 His Ile Asp Ala Val Ala Ala Leu Lys Asn
Thr Lys Asp Val Val Tyr 225 230 235 240 Leu Lys Val Ala Lys Leu Ser
Asn Ala Tyr Leu Ser Asp Ser Tyr Met 245 250 255 Pro Pro Asp Ile Thr
Thr Ser Tyr Ser Asn His Leu Asp Asn Glu Ile 260 265 270 Ser His Ser
Gln Tyr Leu Gly Thr Asp Tyr Pro Thr Ala Arg Thr Pro 275 280 285 Thr
Ser Pro Arg Arg Tyr Ser Ser Val Ala Lys Asp Leu Leu Gly Glu 290 295
300 Glu Thr Ile Pro Arg Glu Pro Arg Arg Ile Val Val His Arg Gly Ser
305 310 315 320 Thr Gly Leu Gly Phe Trp Ile Val Gly Gly Glu Asp Gly
Glu Gly Tyr 325 330 335 Phe Ile Ser Phe Ile Leu Ala Gly Gly Ala Ala
Asp Leu Ser Gly Glu 340 345 350 Leu Arg Lys Asp Asp Gln Ile Leu Ser
Val Asn Gly Val Glu Leu Arg 355 360 365 Asn Ala Ser His Glu Gln Ala
Phe Ile Ala Leu Lys Asn Ala Gly Gln 370 375 380 Thr Gly Thr Ile Ile
Ala Gln Tyr Lys Pro Glu His Tyr Ser Arg Phe 385 390 395 400 Glu Ala
Lys Ile His Ile Leu Arg Glu Gln Leu Met Asn Ser Ser Lys 405 410 415
Gly Ser Gly Thr Ala Ser Leu Arg Ser Leu Pro Lys Arg Gly Phe Tyr 420
425 430 Ile Arg Ala Met Phe Asp Tyr Asp Lys Thr Lys Asp Cys Asn Phe
Leu 435 440 445 Ser Gln Ala Leu Ser Phe His Gln Gly Asp Val Leu His
Val Ile Asp 450 455 460 Ala Arg Asp Glu Glu Trp Trp Gln Ala Arg Arg
Ser His Ser Asp Ser 465 470 475 480 Glu Thr Asp Asp Ile Thr Phe Ile
Pro Ser Lys Arg Arg Val Glu Val 485 490 495 Arg Glu Trp Ser Arg Leu
Lys Ala Lys Trp Trp Gly Ser Ser Ser Gly 500 505 510 Ser Gln Gly Tyr
Glu Asp Ser Val Leu Ser Tyr Glu Thr Ala Thr Gln 515 520 525 Met Glu
Val His Tyr Ala Arg Asp Ile Ile Ile Leu Gly Pro Thr Lys 530 535 540
Asp Glu Ala Asn Asp Asp Leu Leu Ser Glu Phe Phe Asp Lys Phe Gly 545
550 555 560 Ser Cys Val Pro His Gly Thr Arg Pro Lys Arg Glu Tyr Glu
Ile His 565 570 575 Gly Arg Asp Tyr His Phe Val Ser Ser Ile Glu Lys
Met Glu Lys Asp 580 585 590 Ile Gln Ala Lys Lys Phe Ile Glu Ala Gly
Gln Tyr Asn Leu His Leu 595 600 605 Tyr Gly Thr Ser Val Gln Ser Met
Arg Glu Val Ala Glu Gln Gly Lys 610 615 620 His Asn Ile Leu Asp Val
Ser Ala Asn Ala Val Gln Arg Leu Gln Ala 625 630 635 640 Ala His Leu
His Pro Arg Ala Ile Phe Ile Arg Pro Arg Ser Leu Ser 645 650 655 Asn
Val Leu Glu Ile Asn Lys Arg Ile Val Glu Glu Gln Ala Arg Lys 660 665
670 Ala Phe Asp Trp Ala Thr Lys Leu Glu Gln Glu Phe Thr Tyr Cys Phe
675 680 685 Ser Ala Ile Val Glu Gly Asp Ala Phe Glu Glu Ile Tyr His
Lys Val 690 695 700 Lys Asp Val Ile Glu Asp Leu Ser Gly Pro Tyr Glu
Trp Val Pro Ala 705 710 715 720 Arg Glu Arg Leu 27 724 PRT
Artificial Sequence Description of Artificial Sequence Synthetic
Sequence 27 Met Asp Cys Leu Cys Ile Ala Thr Thr Lys Lys Tyr Arg Tyr
Gln Asp 1 5 10 15 Asp Asp Thr Pro Pro Leu Glu His Ser Pro Glu His
Leu Pro Asn Gln 20 25 30 Ala Asn Ser Pro Phe Val Ile Val Asn Thr
Asp Thr Leu Glu Gly Pro 35 40 45 Gly Tyr Glu Leu Gln Val Asn Gly
His Glu Gly Glu Met Glu Tyr Glu 50 55 60 Glu Ile Ile Leu Glu Arg
Gly Asn Ser Gly Leu Gly Lys Ser Ile Ala 65 70 75 80 Gly Gly Thr Asp
Asn Pro Leu Ile Gly Asp Asp Pro Ser Ile Phe Ile 85 90 95 Met Lys
Ile Ile Pro Gly Gly Ala Ala Ala Asn Asp Gly Arg Leu Arg 100
105 110 Val Asn Asp Ser Gln Leu Phe Val Asn Glu Val Asp Val Arg Arg
Val 115 120 125 Thr His Ser Ala Ala Val Glu Ala Ser Lys Glu Ala Gly
Ser Ile Val 130 135 140 Arg Leu Thr Val Met Arg Arg Lys Pro Pro Ala
Glu Val Ile Ile Glu 145 150 155 160 Ile Lys Leu Ile Lys Gly Trp Lys
Gly Leu Gly Phe Ser Ile Ala Gly 165 170 175 Tyr Val Gly Asn Gln His
Ile Pro Gly Asp Ala Ser Ile Tyr Val Thr 180 185 190 Lys Ile Ile Glu
Asp Gly Ala Ala His Lys Asp Gly Arg Leu Glu Ile 195 200 205 Gly Asp
Lys Ile Leu Ala Val Asn Phe Val Gly Leu Glu Asp Val Met 210 215 220
His Glu Gly Ala Val Ala Ala Leu Lys Asn Thr Tyr His Val Val Tyr 225
230 235 240 Leu Lys Val Ala Lys Pro Ile Asn Ala Tyr Leu Ser Asp Ser
Tyr Ala 245 250 255 Lys Pro Asp Ile Thr Thr Ser Tyr Ser Gln Leu Leu
Asp Asn Glu Ile 260 265 270 Ser His Ser Ser Met Leu Gly Thr Asp Tyr
Pro Thr Ala Met Asn Pro 275 280 285 Thr Ser Pro Arg Arg Tyr Ser Pro
Gln Ala Lys Asp Leu Leu Gly Glu 290 295 300 Glu Asp Arg Pro Arg Glu
Pro Arg Arg Ile Val Ile Ser Arg Gly Ser 305 310 315 320 Thr Gly Leu
Gly Phe Asn Thr Val Gly Gly Glu Asp Gly Glu Gly Ile 325 330 335 Val
Ile Ser Phe Ile Leu Ala Gly Gly Pro Trp Asp Leu Ser Gly Glu 340 345
350 Leu Arg Lys Gly Tyr Gln Ile Leu Ser Val Asn Gly Val Asp Ala Arg
355 360 365 Asn Ala Ser His Glu Gln Ala Ala Asp Ala Leu Lys Asn Ala
Gly Gln 370 375 380 Thr Val Glu Ile Ile Ala Gln Tyr Lys Pro Glu Glu
Phe Ser Arg Phe 385 390 395 400 Glu Ala Lys Ile His Asp Gly Arg Glu
Gln Leu Met Asn Ser Ser Leu 405 410 415 His Ser Gly Thr Ala Ser Leu
Arg Ser Asn Ile Lys Arg Gly Phe Tyr 420 425 430 Ile Arg Ala Leu Lys
Asp Tyr Asp Lys Thr Lys Asp Cys Gly Leu Leu 435 440 445 Ser Gln Ala
Leu Ser Phe His Phe Met Asp Val Leu His Val Ile Asp 450 455 460 Ala
Ser Asn Glu Glu Trp Trp Gln Ala Arg Arg Val Gln Ser Asp Ser 465 470
475 480 Glu Thr Asp Asp Ile Gly Arg Ile Pro Ser Lys Arg Arg Val Glu
Arg 485 490 495 Ser Glu Trp Ser Arg Leu Lys Ala Lys Asp Thr Gly Ser
Ser Ser Gly 500 505 510 Ser Gln Gly Arg Val Asp Ser Val Leu Ser Tyr
Glu Thr Val Trp Gln 515 520 525 Met Glu Val His Tyr Ala Arg Pro Tyr
Ile Ile Leu Gly Pro Thr Lys 530 535 540 Asp Arg Asp Asn Asp Asp Leu
Leu Ser Glu Phe Pro Glu Lys Phe Gly 545 550 555 560 Ser Cys Val Pro
His Thr Phe Arg Pro Lys Arg Glu Tyr Glu Ile Asp 565 570 575 His Arg
Asp Tyr His Phe Val Ser Ser Arg Ile Lys Met Glu Lys Asp 580 585 590
Ile Gln Ala His Leu Phe Ile Glu Ala Gly Gln Tyr Asn Ser Met Leu 595
600 605 Tyr Gly Thr Ser Val Gln Ser Val Asn Glu Val Ala Glu Gln Gly
Lys 610 615 620 His Cys Gln Leu Asp Val Ser Ala Asn Ala Val Arg Ser
Leu Gln Ala 625 630 635 640 Ala His Leu His Pro Ile Thr Ile Phe Ile
Arg Pro Arg Ser Leu Glu 645 650 655 Val Val Leu Glu Ile Asn Lys Arg
Ile Thr Trp Glu Gln Ala Arg Lys 660 665 670 Ala Phe Asp Arg Tyr Thr
Lys Leu Glu Gln Glu Phe Thr Glu Ala Phe 675 680 685 Ser Ala Ile Val
Glu Gly Asp Ser Asp Glu Glu Ile Tyr His Lys Val 690 695 700 Lys Arg
Glu Ile Glu Asp Leu Ser Gly Pro Tyr Ile Phe Val Pro Ala 705 710 715
720 Arg Glu Arg Leu 28 724 PRT Artificial Sequence Description of
Artificial Sequence Synthetic Sequence 28 Met Asp Cys Leu Cys Ile
Val Ala Thr Lys Lys Tyr Arg Tyr Gln Asp 1 5 10 15 Glu Glu Thr Pro
Pro Leu Glu His Ser Pro Ala Phe Leu Pro Asn Gln 20 25 30 Ala Asn
Ser Pro Pro Gly Ile Val Asn Thr Asp Thr Leu Glu Ala His 35 40 45
Gly Tyr Glu Leu Gln Val Asn Gly Thr Ile Gly Glu Met Glu Tyr Glu 50
55 60 Glu Ile Thr Lys Glu Arg Gly Asn Ser Gly Leu Gly Phe Leu Ile
Ala 65 70 75 80 Gly Gly Thr Asp Asn Pro His Met Gly Asp Asp Pro Ser
Ile Phe Ile 85 90 95 Thr Asn Ile Ile Pro Gly Gly Ala Ala Ala Gln
Gln Gly Arg Leu Arg 100 105 110 Val Asn Asp Ser Ile Arg Phe Val Asn
Glu Val Asp Val Arg Glu Ser 115 120 125 Thr His Ser Ala Ala Val Glu
Ala Leu Thr Glu Ala Gly Ser Ile Val 130 135 140 Arg Leu Tyr Trp Met
Arg Arg Lys Pro Pro Ala Glu Lys Tyr Ile Glu 145 150 155 160 Ile Lys
Leu Ile Lys Gly Pro Ala Gly Leu Gly Phe Ser Ile Ala Gly 165 170 175
Gly Asp Gly Asn Gln His Ile Pro Gly Asp Asn Glu Ile Tyr Val Thr 180
185 190 Lys Ile Ile Glu Gly Phe Ala Ala His Lys Asp Gly Arg Leu Gln
Gly 195 200 205 Gly Asp Lys Ile Leu Ala Val Asn Ser His Gly Leu Glu
Asp Val Met 210 215 220 His Glu Asp Ile Val Ala Ala Leu Lys Asn Thr
Tyr Asp Lys Val Tyr 225 230 235 240 Leu Lys Val Ala Lys Pro Ser Leu
Ala Tyr Leu Ser Asp Ser Tyr Ala 245 250 255 Pro Met Asp Ile Thr Thr
Ser Tyr Ser Gln His Asn Asp Asn Glu Ile 260 265 270 Ser His Ser Ser
Tyr Gln Gly Thr Asp Tyr Pro Thr Ala Met Thr Arg 275 280 285 Thr Ser
Pro Arg Arg Tyr Ser Pro Val Ser Lys Asp Leu Leu Gly Glu 290 295 300
Glu Asp Ile Thr Arg Glu Pro Arg Arg Ile Val Ile His Val Gly Ser 305
310 315 320 Thr Gly Leu Gly Phe Asn Ile Trp Gly Gly Glu Asp Gly Glu
Gly Ile 325 330 335 Phe Tyr Ser Phe Ile Leu Ala Gly Gly Pro Ala Ala
Leu Ser Gly Glu 340 345 350 Leu Arg Lys Gly Asp Asp Ile Leu Ser Val
Asn Gly Val Asp Leu Glu 355 360 365 Asn Ala Ser His Glu Gln Ala Ala
Ile Phe Leu Lys Asn Ala Gly Gln 370 375 380 Thr Val Thr Gly Ile Ala
Gln Tyr Lys Pro Glu Glu Tyr His Arg Phe 385 390 395 400 Glu Ala Lys
Ile His Asp Leu Ile Glu Gln Leu Met Asn Ser Ser Leu 405 410 415 Gly
Lys Gly Thr Ala Ser Leu Arg Ser Asn Pro Leu Arg Gly Phe Tyr 420 425
430 Ile Arg Ala Leu Phe Met Tyr Asp Lys Thr Lys Asp Cys Gly Phe Asn
435 440 445 Ser Gln Ala Leu Ser Phe His Phe Gly Gln Val Leu His Val
Ile Asp 450 455 460 Ala Ser Asp Arg Glu Trp Trp Gln Ala Arg Arg Val
His Thr Asp Ser 465 470 475 480 Glu Thr Asp Asp Ile Gly Phe Val Pro
Ser Lys Arg Arg Val Glu Arg 485 490 495 Arg Trp Trp Ser Arg Leu Lys
Ala Lys Asp Trp Tyr Ser Ser Ser Gly 500 505 510 Ser Gln Gly Arg Glu
Ala Ser Val Leu Ser Tyr Glu Thr Val Thr Asp 515 520 525 Met Glu Val
His Tyr Ala Arg Pro Ile Glu Ile Leu Gly Pro Thr Lys 530 535 540 Asp
Arg Ala Phe Asp Asp Leu Leu Ser Glu Phe Pro Asp Gly Phe Gly 545 550
555 560 Ser Cys Val Pro His Thr Thr His Pro Lys Arg Glu Tyr Glu Ile
Asp 565 570 575 Gly Ile Asp Tyr His Phe Val Ser Ser Arg Glu Lys Met
Glu Lys Asp 580 585 590 Ile Gln Ala His Lys Leu Ile Glu Ala Gly Gln
Tyr Asn Ser His Met 595 600 605 Tyr Gly Thr Ser Val Gln Ser Val Arg
Asn Val Ala Glu Gln Gly Lys 610 615 620 His Cys Ile Gln Asp Val Ser
Ala Asn Ala Val Arg Arg Arg Gln Ala 625 630 635 640 Ala His Leu His
Pro Ile Ala Ser Phe Ile Arg Pro Arg Ser Leu Glu 645 650 655 Asn Thr
Leu Glu Ile Asn Lys Arg Ile Thr Glu Val Gln Ala Arg Lys 660 665 670
Ala Phe Asp Arg Ala Trp Lys Leu Glu Gln Glu Phe Thr Glu Cys Tyr 675
680 685 Ser Ala Ile Val Glu Gly Asp Ser Phe Ala Glu Ile Tyr His Lys
Val 690 695 700 Lys Arg Val Asp Glu Asp Leu Ser Gly Pro Tyr Ile Trp
Glu Pro Ala 705 710 715 720 Arg Glu Arg Leu 29 724 PRT Artificial
Sequence Description of Artificial Sequence Synthetic Sequence 29
Met Asp Cys Leu Cys Ile Val Thr Ala Lys Lys Tyr Arg Tyr Gln Asp 1 5
10 15 Glu Asp Asp Pro Pro Leu Glu His Ser Pro Ala His Glu Pro Asn
Gln 20 25 30 Ala Asn Ser Pro Pro Val Phe Val Asn Thr Asp Thr Leu
Glu Ala Pro 35 40 45 His Tyr Glu Leu Gln Val Asn Gly Thr Glu Ile
Glu Met Glu Tyr Glu 50 55 60 Glu Ile Thr Leu Lys Arg Gly Asn Ser
Gly Leu Gly Phe Ser Leu Ala 65 70 75 80 Gly Gly Thr Asp Asn Pro His
Ile Met Asp Asp Pro Ser Ile Phe Ile 85 90 95 Thr Lys Asn Ile Pro
Gly Gly Ala Ala Ala Gln Asp Gln Arg Leu Arg 100 105 110 Val Asn Asp
Ser Ile Leu Arg Val Asn Glu Val Asp Val Arg Glu Val 115 120 125 Ser
His Ser Ala Ala Val Glu Ala Leu Lys Thr Ala Gly Ser Ile Val 130 135
140 Arg Leu Tyr Val Val Arg Arg Lys Pro Pro Ala Glu Lys Ile Trp Glu
145 150 155 160 Ile Lys Leu Ile Lys Gly Pro Lys Tyr Leu Gly Phe Ser
Ile Ala Gly 165 170 175 Gly Val Ala Asn Gln His Ile Pro Gly Asp Asn
Ser Asp Tyr Val Thr 180 185 190 Lys Ile Ile Glu Gly Gly Glu Ala His
Lys Asp Gly Arg Leu Gln Ile 195 200 205 Phe Asp Lys Ile Leu Ala Val
Asn Ser Val His Leu Glu Asp Val Met 210 215 220 His Glu Asp Ala Ile
Ala Ala Leu Lys Asn Thr Tyr Asp Val Lys Tyr 225 230 235 240 Leu Lys
Val Ala Lys Pro Ser Asn Leu Tyr Leu Ser Asp Ser Tyr Ala 245 250 255
Pro Pro Met Ile Thr Thr Ser Tyr Ser Gln His Leu Asn Asn Glu Ile 260
265 270 Ser His Ser Ser Tyr Leu Gln Thr Asp Tyr Pro Thr Ala Met Thr
Pro 275 280 285 Arg Ser Pro Arg Arg Tyr Ser Pro Val Ala Ser Asp Leu
Leu Gly Glu 290 295 300 Glu Asp Ile Pro Thr Glu Pro Arg Arg Ile Val
Ile His Arg Val Ser 305 310 315 320 Thr Gly Leu Gly Phe Asn Ile Val
Trp Gly Glu Asp Gly Glu Gly Ile 325 330 335 Phe Ile Tyr Phe Ile Leu
Ala Gly Gly Pro Ala Asp Ala Ser Gly Glu 340 345 350 Leu Arg Lys Gly
Asp Gln Asp Leu Ser Val Asn Gly Val Asp Leu Arg 355 360 365 Glu Ala
Ser His Glu Gln Ala Ala Ile Ala Phe Lys Asn Ala Gly Gln 370 375 380
Thr Val Thr Ile Gly Ala Gln Tyr Lys Pro Glu Glu Tyr Ser His Phe 385
390 395 400 Glu Ala Lys Ile His Asp Leu Arg Ile Gln Leu Met Asn Ser
Ser Leu 405 410 415 Gly Ser Lys Thr Ala Ser Leu Arg Ser Asn Pro Lys
Leu Gly Phe Tyr 420 425 430 Ile Arg Ala Leu Phe Asp Met Asp Lys Thr
Lys Asp Cys Gly Phe Leu 435 440 445 Asn Gln Ala Leu Ser Phe His Phe
Gly Asp Gln Leu His Val Ile Asp 450 455 460 Ala Ser Asp Glu Arg Trp
Trp Gln Ala Arg Arg Val His Ser Ser Ser 465 470 475 480 Glu Thr Asp
Asp Ile Gly Phe Ile Thr Ser Lys Arg Arg Val Glu Arg 485 490 495 Arg
Glu Val Ser Arg Leu Lys Ala Lys Asp Trp Gly Trp Ser Ser Gly 500 505
510 Ser Gln Gly Arg Glu Asp Tyr Val Leu Ser Tyr Glu Thr Val Thr Gln
515 520 525 Ala Glu Val His Tyr Ala Arg Pro Ile Ile Asp Leu Gly Pro
Thr Lys 530 535 540 Asp Arg Ala Asn Glu Asp Leu Leu Ser Glu Phe Pro
Asp Lys Gly Gly 545 550 555 560 Ser Cys Val Pro His Thr Thr Arg His
Lys Arg Glu Tyr Glu Ile Asp 565 570 575 Gly Arg Ile Tyr His Phe Val
Ser Ser Arg Glu Lys Lys Glu Lys Asp 580 585 590 Ile Gln Ala His Lys
Phe Leu Glu Ala Gly Gln Tyr Asn Ser His Leu 595 600 605 Met Gly Thr
Ser Val Gln Ser Val Arg Glu Asn Ala Glu Gln Gly Lys 610 615 620 His
Cys Ile Leu Gln Val Ser Ala Asn Ala Val Arg Arg Leu Arg Ala 625 630
635 640 Ala His Leu His Pro Ile Ala Ile Ser Ile Arg Pro Arg Ser Leu
Glu 645 650 655 Asn Val Thr Glu Ile Asn Lys Arg Ile Thr Glu Glu Val
Ala Arg Lys 660 665 670 Ala Phe Asp Arg Ala Thr Trp Leu Glu Gln Glu
Phe Thr Glu Cys Phe 675 680 685 Tyr Ala Ile Val Glu Gly Asp Ser Phe
Glu Ala Ile Tyr His Lys Val 690 695 700 Lys Arg Val Ile Asp Asp Leu
Ser Gly Pro Tyr Ile Trp Val Glu Ala 705 710 715 720 Arg Glu Arg Leu
30 724 PRT Artificial Sequence Description of Artificial Sequence
Synthetic Sequence 30 Met Asp Cys Leu Cys Ile Val Thr Thr Ala Lys
Tyr Arg Tyr Gln Asp 1 5 10 15 Glu Asp Thr Asp Pro Leu Glu His Ser
Pro Ala His Leu Glu Asn Gln 20 25 30 Ala Asn Ser Pro Pro Val Ile
Phe Asn Thr Asp Thr Leu Glu Ala Pro 35 40 45 Gly Gly Glu Leu Gln
Val Asn Gly Thr Glu Gly His Met Glu Tyr Glu 50 55 60 Glu Ile Thr
Leu Glu Ile Gly Asn Ser Gly Leu Gly Phe Ser Ile Lys 65 70 75 80 Gly
Gly Thr Asp Asn Pro His Ile Gly Leu Asp Pro Ser Ile Phe Ile 85 90
95 Thr Lys Ile Met Pro Gly Gly Ala Ala Ala Gln Asp Gly Asn Leu Arg
100 105 110 Val Asn Asp Ser Ile Leu Phe Gln Asn Glu Val Asp Val Arg
Glu Val 115 120 125 Thr Arg Ser Ala Ala Val Glu Ala Leu Lys Glu Ser
Gly Ser Ile Val 130 135 140 Arg Leu Tyr Val Met Thr Arg Lys Pro Pro
Ala Glu Lys Ile Ile Val 145 150 155 160 Ile Lys Leu Ile Lys Gly Pro
Lys Gly Trp Gly Phe Ser Ile Ala Gly 165 170 175 Gly Val Gly Tyr Gln
His Ile Pro Gly Asp Asn Ser Ile Ala Val Thr 180 185 190 Lys Ile Ile
Glu Gly Gly Ala Asp His Lys Asp Gly Arg Leu Gln Ile 195 200 205 Gly
Glu Lys Ile Leu Ala Val Asn Ser Val Gly Phe Glu Asp Val Met 210 215
220 His Glu Asp Ala Val Gly Ala Leu Lys Asn Thr Tyr Asp Val Val His
225 230 235 240 Leu Lys Val Ala Lys Pro Ser Asn Ala Ile Leu Ser Asp
Ser Tyr Ala 245 250 255 Pro Pro Asp Lys Thr Thr Ser Tyr Ser Gln His
Leu Asp Leu Glu Ile 260 265 270 Ser His Ser Ser Tyr Leu Gly Met Asp
Tyr Pro Thr Ala Met Thr Pro 275 280 285 Thr Asn Pro Arg Arg Tyr Ser
Pro Val Ala Lys Gln Leu Leu Gly Glu 290 295 300 Glu Asp Ile Pro Arg
Arg Pro Arg Arg Ile Val Ile His Arg Gly Thr 305 310 315 320 Thr Gly
Leu Gly Phe Asn Ile Val Gly Val Glu Asp Gly Glu Gly Ile 325 330 335
Phe Ile Ser Trp Ile Leu Ala Gly Gly Pro Ala Asp Leu Tyr Gly Glu 340
345 350
Leu Arg Lys Gly Asp Gln Ile Ala Ser Val Asn Gly Val Asp Leu Arg 355
360 365 Asn Asp Ser His Glu Gln Ala Ala Ile Ala Leu Glu Asn Ala Gly
Gln 370 375 380 Thr Val Thr Ile Ile Phe Gln Tyr Lys Pro Glu Glu Tyr
Ser Arg Gly 385 390 395 400 Glu Ala Lys Ile His Asp Leu Arg Glu His
Leu Met Asn Ser Ser Leu 405 410 415 Gly Ser Gly Ile Ala Ser Leu Arg
Ser Asn Pro Lys Arg Lys Phe Tyr 420 425 430 Ile Arg Ala Leu Phe Asp
Tyr Leu Lys Thr Lys Asp Cys Gly Phe Leu 435 440 445 Ser Met Ala Leu
Ser Phe His Phe Gly Asp Val Asn His Val Ile Asp 450 455 460 Ala Ser
Asp Glu Glu Gln Trp Gln Ala Arg Arg Val His Ser Asp Arg 465 470 475
480 Glu Thr Asp Asp Ile Gly Phe Ile Pro Thr Lys Arg Arg Val Glu Arg
485 490 495 Arg Glu Trp Val Arg Leu Lys Ala Lys Asp Trp Gly Ser Trp
Ser Gly 500 505 510 Ser Gln Gly Arg Glu Asp Ser Tyr Leu Ser Tyr Glu
Thr Val Thr Gln 515 520 525 Met Ala Val His Tyr Ala Arg Pro Ile Ile
Ile Asp Gly Pro Thr Lys 530 535 540 Asp Arg Ala Asn Asp Glu Leu Leu
Ser Glu Phe Pro Asp Lys Phe Phe 545 550 555 560 Ser Cys Val Pro His
Thr Thr Arg Pro Gly Arg Glu Tyr Glu Ile Asp 565 570 575 Gly Arg Asp
His His Phe Val Ser Ser Arg Glu Lys Met Ile Lys Asp 580 585 590 Ile
Gln Ala His Lys Phe Ile Lys Ala Gly Gln Tyr Asn Ser His Leu 595 600
605 Tyr Leu Thr Ser Val Gln Ser Val Arg Glu Val Met Glu Gln Gly Lys
610 615 620 His Cys Ile Leu Asp Asn Ser Ala Asn Ala Val Arg Arg Leu
Gln Gln 625 630 635 640 Ala His Leu His Pro Ile Ala Ile Phe Arg Arg
Pro Arg Ser Leu Glu 645 650 655 Asn Val Leu Ser Ile Asn Lys Arg Ile
Thr Glu Glu Gln Thr Arg Lys 660 665 670 Ala Phe Asp Arg Ala Thr Lys
Val Glu Gln Glu Phe Thr Glu Cys Phe 675 680 685 Ser Trp Ile Val Glu
Gly Asp Ser Phe Glu Glu Tyr Tyr His Lys Val 690 695 700 Lys Arg Val
Ile Glu Ala Leu Ser Gly Pro Tyr Ile Trp Val Pro Asp 705 710 715 720
Arg Glu Arg Leu 31 830 PRT Artificial Sequence Description of
Artificial Sequence Synthetic Sequence 31 Met Ala Asp Arg Ala Glu
Met Phe Ser Leu Ser Thr Phe His Ser Leu 1 5 10 15 Ser Pro Pro Gly
Cys Arg Pro Pro Gln Asp Ile Ser Leu Glu Glu Phe 20 25 30 Asp Asp
Glu Asp Leu Ser Glu Ile Thr Asp Asp Cys Gly Leu Gly Leu 35 40 45
Ser Tyr Asp Ser Asp His Cys Glu Lys Asp Ser Leu Ser Leu Gly Arg 50
55 60 Ser Glu Gln Pro His Pro Ile Cys Ser Phe Gln Asp Asp Phe Gln
Glu 65 70 75 80 Phe Glu Met Ile Asp Asp His Gln Gly Gly Gly His Glu
Glu Glu Glu 85 90 95 Glu Glu Glu Glu Glu Glu Glu Asp Gly Asp Arg
Gln Gly Lys Ala Gly 100 105 110 Gly Gly Pro Gly Ser Gln Ala Leu Ala
Gly Asp Ser Leu Ile Pro Ser 115 120 125 Pro Ser Leu Glu Glu Ser His
Lys Leu Arg Pro Thr Thr Leu His Leu 130 135 140 Thr Thr Leu Gly Ala
Gln Asp Ser Leu Asn Asn Asn Asn Gly Gly Phe 145 150 155 160 Thr Ser
Ala Pro Pro Ser Ser Trp Gln Glu Thr Val Leu Arg Ser Pro 165 170 175
Ala Gln Glu Pro Leu Lys Glu Leu Pro Ala Pro Leu Leu Pro Ala Glu 180
185 190 Glu Glu Arg His Glu Val Gln Ser Leu Ala Arg Pro Gly Cys Asp
Cys 195 200 205 Glu Gly Asn Gln Pro Pro Glu Pro Pro Ala Ser Ser Gly
Gly Ala Ser 210 215 220 Pro Ser Ser Asp Pro Gly Ile Glu Ala Asp Leu
Arg Ser His Ser Ser 225 230 235 240 Gly Gly His Glu Gly Arg Arg Ser
Ser Gln Glu Leu Ser Ser Pro Gly 245 250 255 Ser Asp Ser Glu Asp Ala
Gly Gly Ala Arg Leu Gly Arg Met Ile Ser 260 265 270 Ser Ile Ser Glu
Thr Glu Leu Glu Leu Ser Ser Asp Gly Gly Ser Ser 275 280 285 Ser Gly
Arg Ser Ser His Leu Thr Asn Ser Ile Glu Glu Ala Ser Ser 290 295 300
Pro Ala Ser Glu Pro Glu Pro Glu Pro Glu Pro Leu His Glu Pro Pro 305
310 315 320 Arg Arg Pro Ala Phe Leu Pro Val Gly Gln Asp Asp Thr Asn
Ser Glu 325 330 335 Tyr Glu Ser Gly Ser Glu Ser Glu Pro Asp Leu Ser
Glu Asp Ala Asp 340 345 350 Ser Pro Trp Leu Leu Ser Asn Leu Val Ser
Arg Met Ile Ser Glu Gly 355 360 365 Ser Ser Pro Ile Arg Cys Pro Gly
Gln Cys Leu Ser Pro Ala Pro Arg 370 375 380 Leu Pro Glu Glu Ala Ala
Ser Gln Ala Asn Ser Val Pro Gln Asp Cys 385 390 395 400 Gln Asp Pro
Glu Ala Gly Pro His Val Glu Leu Val Asp Met Asp Thr 405 410 415 Leu
Cys Gly Pro Pro Pro Pro Ala Pro Ala Ala Pro Arg Leu Gly Pro 420 425
430 Ala Gln Pro Gly Pro Cys Leu Phe Leu Ser Asn Pro Thr Arg Asp Thr
435 440 445 Ile Thr Pro Leu Trp Ala Thr Pro Gly Arg Thr Ala Arg Pro
Gly Arg 450 455 460 Ser Cys Ser Ala Ala Cys Ser Glu Glu Glu Glu Glu
Asp Glu Glu Glu 465 470 475 480 Asp Glu Glu Asp Glu Glu Asp Ala Glu
Asp Ser Val Val Pro Pro Gly 485 490 495 Ser Arg Thr Thr Gly Ser Thr
Ala Pro Leu Asp Ala Ser Leu Val Tyr 500 505 510 Asp Ala Val Lys Tyr
Thr Leu Val Val Asp Glu His Thr Gln Leu Glu 515 520 525 Leu Val Ser
Leu Arg Arg Cys Ala Gly Leu Gly Asn Asp Ser Glu Glu 530 535 540 Asp
Ser Ser Cys Glu Ala Ser Glu Glu Glu Ala Gly Ala Thr Leu Leu 545 550
555 560 Gly Ser Asp Gln Val Pro Glu Asp Ala Ser Pro Asp Ser Pro Asp
Leu 565 570 575 Thr Phe Ser Lys Lys Phe Leu Asn Val Phe Val Asn Ser
Thr Ser Arg 580 585 590 Ser Ser Ser Thr Glu Ser Phe Gly Leu Phe Ser
Cys Val Xaa Asn Gly 595 600 605 Glu Glu Arg Glu Gln Thr His Arg Ala
Val Phe Arg Phe Ile Pro Arg 610 615 620 His Pro Asp Glu Leu Glu Leu
Asp Val Asp Asp Pro Val Leu Val Glu 625 630 635 640 Ala Glu Glu Asp
Asp Phe Trp Phe Arg Gly Phe Asn Met Arg Thr Gly 645 650 655 Glu Arg
Gly Val Phe Pro Ala Phe Tyr Ala His Ala Val Pro Gly Pro 660 665 670
Ala Lys Asp Leu Leu Gly Ser Lys Arg Ser Pro Cys Trp Val Asp Arg 675
680 685 Phe Asp Val Gln Phe Leu Gly Ser Val Glu Val Pro Cys His Gln
Gly 690 695 700 Asn Gly Ile Leu Cys Ala Ala Met Gln Lys Ile Ala Thr
Ala Arg Lys 705 710 715 720 Leu Thr Val His Leu Arg Pro Pro Ala Ser
Cys Asp Leu Glu Ile Ser 725 730 735 Leu Arg Gly Val Lys Leu Ser Leu
Ser Gly Gly Gly Pro Glu Phe Gln 740 745 750 Arg Cys Ser His Phe Phe
Gln Met Lys Asn Ile Ser Phe Cys Gly Cys 755 760 765 His Pro Arg Asn
Ser Cys Tyr Phe Gly Phe Ile Thr Lys His Pro Leu 770 775 780 Leu Ser
Arg Phe Ala Cys His Val Phe Val Ser Gln Glu Ser Met Arg 785 790 795
800 Pro Val Ala Arg Ser Val Gly Arg Ala Phe Leu Glu Tyr Tyr Gln Glu
805 810 815 His Leu Ala Phe Ala Cys Pro Thr Glu Asp Ile Tyr Leu Glu
820 825 830 32 830 PRT Artificial Sequence Description of
Artificial Sequence Synthetic Sequence 32 Met Asp Asp Arg Ala Glu
Met Phe Ser Leu Ser Glu Phe His Ser Leu 1 5 10 15 Ser Pro Pro Gly
Cys Phe Pro Pro Gln Asp Ile Ser Leu Glu Glu Gly 20 25 30 Asp Asp
Glu Asp Leu Ser Glu Ile Thr His Asp Cys Gly Leu Gly Leu 35 40 45
Ser Tyr Asp Ile Asp His Cys Glu Lys Asp Ser Leu Ser Lys Gly Arg 50
55 60 Ser Glu Gln Pro His Pro Ile Leu Ser Phe Gln Asp Asp Phe Gln
Glu 65 70 75 80 Phe Met Met Ile Asp Asp His Gln Gly Gly Gly Asn Glu
Glu Glu Glu 85 90 95 Glu Glu Glu Glu Glu Gln Glu Asp Gly Asp Arg
Gln Gly Lys Ala Arg 100 105 110 Gly Gly Pro Gly Ser Gln Ala Leu Ala
Ser Asp Ser Leu Ile Pro Ser 115 120 125 Pro Ser Leu Thr Glu Ser His
Lys Leu Arg Pro Thr Thr Val His Leu 130 135 140 Thr Thr Leu Gly Ala
Gln Asp Trp Leu Asn Asn Asn Asn Gly Gly Phe 145 150 155 160 Thr Tyr
Ala Pro Pro Ser Ser Trp Gln Glu Thr Ala Leu Arg Ser Pro 165 170 175
Ala Gln Glu Pro Leu Asp Glu Leu Pro Ala Pro Leu Leu Pro Ala Phe 180
185 190 Glu Glu Arg His Glu Val Gln Ser Leu Gly Arg Pro Gly Cys Asp
Cys 195 200 205 Glu Gly Asn His Pro Pro Glu Pro Pro Ala Ser Ser Gly
Ile Ala Ser 210 215 220 Pro Ser Ser Asp Pro Gly Ile Lys Ala Asp Leu
Arg Ser His Ser Ser 225 230 235 240 Gly Leu His Glu Gly Arg Arg Ser
Ser Gln Glu Met Ser Ser Pro Gly 245 250 255 Ser Asp Ser Glu Asp Asn
Gly Gly Ala Arg Leu Gly Arg Met Ile Gln 260 265 270 Ser Ile Ser Glu
Thr Glu Leu Glu Leu Arg Ser Asp Gly Gly Ser Ser 275 280 285 Ser Gly
Arg Thr Ser His Leu Thr Asn Ser Ile Glu Glu Val Ser Ser 290 295 300
Pro Ala Ser Glu Pro Glu Pro Trp Pro Glu Pro Leu His Glu Pro Pro 305
310 315 320 Arg Tyr Pro Ala Phe Leu Pro Val Gly Gln Asp Ala Thr Asn
Ser Glu 325 330 335 Tyr Glu Ser Gly Ser Asp Ser Glu Pro Asp Leu Ser
Glu Asp Ala Glu 340 345 350 Ser Pro Trp Leu Leu Ser Asn Leu Val Phe
Arg Met Ile Ser Glu Gly 355 360 365 Ser Ser Pro Gly Arg Cys Pro Gly
Gln Cys Leu Ser Pro His Pro Arg 370 375 380 Leu Pro Glu Glu Ala Ala
Ser Ile Ala Asn Ser Val Pro Gln Asp Cys 385 390 395 400 Gln Lys Pro
Glu Ala Gly Pro His Val Glu Leu Leu Asp Met Asp Thr 405 410 415 Leu
Cys Gly Pro Pro Met Pro Ala Pro Ala Ala Pro Arg Leu Gly Asn 420 425
430 Ala Gln Pro Gly Pro Cys Leu Phe Leu Gln Asn Pro Thr Arg Asp Thr
435 440 445 Ile Thr Pro Arg Trp Ala Thr Pro Gly Arg Thr Ala Arg Ser
Gly Arg 450 455 460 Ser Cys Ser Ala Ala Cys Ser Thr Glu Glu Glu Glu
Asp Glu Glu Glu 465 470 475 480 Asp Val Glu Asp Glu Glu Asp Ala Glu
Asp Ser Trp Val Pro Pro Gly 485 490 495 Ser Arg Thr Thr Gly Tyr Thr
Ala Pro Leu Asp Ala Ser Leu Val Ala 500 505 510 Asp Ala Val Lys Tyr
Thr Leu Val Val Glu Glu His Thr Gln Leu Glu 515 520 525 Leu Val Ser
Phe Arg Arg Cys Ala Gly Leu Gly Asn Asp Gly Glu Glu 530 535 540 Asp
Ser Ser Cys Glu Ala Ser His Glu Glu Ala Gly Ala Thr Leu Leu 545 550
555 560 Gly Ile Asp Gln Val Pro Glu Asp Ala Ser Pro Lys Ser Pro Asp
Leu 565 570 575 Thr Phe Ser Lys Lys Leu Leu Asn Val Phe Val Asn Ser
Thr Ser Met 580 585 590 Ser Ser Ser Thr Glu Ser Phe Gly Leu Asn Ser
Cys Val Xaa Asn Gly 595 600 605 Glu Glu Arg Gln Gln Thr His Arg Ala
Val Phe Arg Phe Arg Pro Arg 610 615 620 His Pro Asp Glu Leu Glu Leu
Ser Val Asp Asp Pro Val Leu Val Glu 625 630 635 640 Ala Thr Glu Asp
Asp Phe Trp Phe Arg Gly Phe Val Met Arg Thr Gly 645 650 655 Glu Arg
Gly Val Phe Trp Ala Phe Tyr Ala His Ala Val Pro Gly Tyr 660 665 670
Ala Lys Asp Leu Leu Gly Ser Lys Arg Ala Pro Cys Trp Val Asp Arg 675
680 685 Phe Asp Val Asp Phe Leu Gly Ser Val Glu Val Pro Cys Glu Gln
Gly 690 695 700 Asn Gly Ile Leu Cys Ala Ala Phe Gln Lys Ile Ala Thr
Ala Arg Lys 705 710 715 720 Leu Gly Val His Leu Arg Pro Pro Ala Ser
Cys His Leu Glu Ile Ser 725 730 735 Leu Arg Gly Val Lys Ile Ser Leu
Ser Gly Gly Gly Pro Glu Phe Lys 740 745 750 Arg Cys Ser His Phe Phe
Gln Met Lys Leu Ile Ser Phe Cys Gly Cys 755 760 765 His Pro Arg Met
Ser Cys Tyr Phe Gly Phe Ile Thr Lys Asn Pro Leu 770 775 780 Leu Ser
Arg Phe Ala Cys His Gln Phe Val Ser Gln Glu Ser Met Arg 785 790 795
800 Pro Arg Ala Arg Ser Val Gly Arg Ala Phe Leu Ser Tyr Tyr Gln Glu
805 810 815 His Leu Ala Phe Ala Thr Pro Thr Glu Asp Ile Tyr Leu Glu
820 825 830 33 830 PRT Artificial Sequence Description of
Artificial Sequence Synthetic Sequence 33 Met Ala Ala Arg Ala Glu
Met Phe Ser Leu Ser Thr Asp His Ser Leu 1 5 10 15 Ser Pro Pro Gly
Cys Arg Glu Pro Gln Asp Ile Ser Leu Glu Glu Phe 20 25 30 Phe Asp
Glu Asp Leu Ser Glu Ile Thr Asp Gly Cys Gly Leu Gly Leu 35 40 45
Ser Tyr Asp Ser His His Cys Glu Lys Asp Ser Leu Ser Leu Ile Arg 50
55 60 Ser Glu Gln Pro His Pro Ile Cys Lys Phe Gln Asp Asp Phe Gln
Glu 65 70 75 80 Phe Glu Leu Ile Asp Asp His Gln Gly Gly Gly His Met
Glu Glu Glu 85 90 95 Glu Glu Glu Glu Glu Glu Asn Asp Gly Asp Arg
Gln Gly Lys Ala Gly 100 105 110 Gln Gly Pro Gly Ser Gln Ala Leu Ala
Gly Arg Ser Leu Ile Pro Ser 115 120 125 Pro Ser Leu Glu Ser Ser His
Lys Leu Arg Pro Thr Thr Leu Thr Leu 130 135 140 Thr Thr Leu Gly Ala
Gln Asp Ser Val Asn Asn Asn Asn Gly Gly Phe 145 150 155 160 Thr Ser
Trp Pro Pro Ser Ser Trp Gln Glu Thr Val Tyr Arg Ser Pro 165 170 175
Ala Gln Glu Pro Leu Lys Ala Leu Pro Ala Pro Leu Leu Pro Ala Glu 180
185 190 Asp Glu Arg His Glu Val Gln Ser Leu Ala Glu Pro Gly Cys Asp
Cys 195 200 205 Glu Gly Asn Gln Phe Pro Glu Pro Pro Ala Ser Ser Gly
Gly Gly Ser 210 215 220 Pro Ser Ser Asp Pro Gly Ile Glu His Asp Leu
Arg Ser His Ser Ser 225 230 235 240 Gly Gly Ile Glu Gly Arg Arg Ser
Ser Gln Glu Leu Lys Ser Pro Gly 245 250 255 Ser Asp Ser Glu Asp Ala
Leu Gly Ala Arg Leu Gly Arg Met Ile Ser 260 265 270 Met Ile Ser Glu
Thr Glu Leu Glu Leu Ser Asn Asp Gly Gly Ser Ser 275 280 285 Ser Gly
Arg Ser Gln His Leu Thr Asn Ser Ile Glu Glu Ala Arg Ser 290 295 300
Pro Ala Ser Glu Pro Glu Pro Glu Ser Glu Pro Leu His Glu Pro Pro 305
310 315 320 Arg Arg Thr Ala Phe Leu Pro Val Gly Gln Asp Asp Val Asn
Ser Glu 325 330 335 Tyr Glu Ser Gly Ser Glu Trp Glu Pro Asp Leu Ser
Glu Asp Ala Asp 340 345 350 Tyr Pro Trp Leu Leu Ser Asn Leu Val Ser
Ala Met Ile Ser Glu Gly 355 360 365 Ser Ser Pro Ile Asp Cys Pro Gly
Gln Cys Leu Ser Pro Ala Glu Arg 370
375 380 Leu Pro Glu Glu Ala Ala Ser Gln Phe Asn Ser Val Pro Gln Asp
Cys 385 390 395 400 Gln Asp Gly Glu Ala Gly Pro His Val Glu Leu Val
His Met Asp Thr 405 410 415 Leu Cys Gly Pro Pro Pro Ile Ala Pro Ala
Ala Pro Arg Leu Gly Pro 420 425 430 Lys Gln Pro Gly Pro Cys Leu Phe
Leu Ser Leu Pro Thr Arg Asp Thr 435 440 445 Ile Thr Pro Leu Met Ala
Thr Pro Gly Arg Thr Ala Arg Pro Asn Arg 450 455 460 Ser Cys Ser Ala
Ala Cys Ser Glu Gln Glu Glu Glu Asp Glu Glu Glu 465 470 475 480 Asp
Glu Arg Asp Glu Glu Asp Ala Glu Asp Ser Val Ser Pro Pro Gly 485 490
495 Ser Arg Thr Thr Gly Ser Val Ala Pro Leu Asp Ala Ser Leu Val Tyr
500 505 510 Trp Ala Val Lys Tyr Thr Leu Val Val Asp Tyr His Thr Gln
Leu Glu 515 520 525 Leu Val Ser Leu Ala Arg Cys Ala Gly Leu Gly Asn
Asp Ser Asp Glu 530 535 540 Asp Ser Ser Cys Glu Ala Ser Glu Phe Glu
Ala Gly Ala Thr Leu Leu 545 550 555 560 Gly Ser Gly Gln Val Pro Glu
Asp Ala Ser Pro Asp His Pro Asp Leu 565 570 575 Thr Phe Ser Lys Lys
Phe Ile Asn Val Phe Val Asn Ser Thr Ser Arg 580 585 590 Lys Ser Ser
Thr Glu Ser Phe Gly Leu Phe Leu Cys Val Xaa Asn Gly 595 600 605 Glu
Glu Arg Glu Met Thr His Arg Ala Val Phe Arg Phe Ile Asn Arg 610 615
620 His Pro Asp Glu Leu Glu Leu Asp Gln Asp Asp Pro Val Leu Val Glu
625 630 635 640 Ala Glu Arg Asp Asp Phe Trp Phe Arg Gly Phe Asn Ser
Arg Thr Gly 645 650 655 Glu Arg Gly Val Phe Pro Thr Phe Tyr Ala His
Ala Val Pro Gly Pro 660 665 670 Val Lys Asp Leu Leu Gly Ser Lys Arg
Ser Trp Cys Trp Val Asp Arg 675 680 685 Phe Asp Val Gln Tyr Leu Gly
Ser Val Glu Val Pro Cys His Ala Gly 690 695 700 Asn Gly Ile Leu Cys
Ala Ala Met Asp Lys Ile Ala Thr Ala Arg Lys 705 710 715 720 Leu Thr
Glu His Leu Arg Pro Pro Ala Ser Cys Asp Phe Glu Ile Ser 725 730 735
Leu Arg Gly Val Lys Leu Gly Leu Ser Gly Gly Gly Pro Glu Phe Gln 740
745 750 His Cys Ser His Phe Phe Gln Met Lys Asn Lys Ser Phe Cys Gly
Cys 755 760 765 His Pro Arg Asn Leu Cys Tyr Phe Gly Phe Ile Thr Lys
His Met Leu 770 775 780 Leu Ser Arg Phe Ala Cys His Val Asn Val Ser
Gln Glu Ser Met Arg 785 790 795 800 Pro Val Gln Arg Ser Val Gly Arg
Ala Phe Leu Glu Arg Tyr Gln Glu 805 810 815 His Leu Ala Phe Ala Cys
Ser Thr Glu Asp Ile Tyr Leu Glu 820 825 830 34 830 PRT Artificial
Sequence Description of Artificial Sequence Synthetic Sequence 34
Met Ala Asp Ala Ala Glu Met Phe Ser Leu Ser Thr Phe Asp Ser Leu 1 5
10 15 Ser Pro Pro Gly Cys Arg Pro Glu Gln Asp Ile Ser Leu Glu Glu
Phe 20 25 30 Asp Phe Glu Asp Leu Ser Glu Ile Thr Asp Asp Gly Gly
Leu Gly Leu 35 40 45 Ser Tyr Asp Ser Asp His Cys Glu Lys Asp Ser
Leu Ser Leu Gly Ile 50 55 60 Ser Glu Gln Pro His Pro Ile Cys Ser
Lys Gln Asp Asp Phe Gln Glu 65 70 75 80 Phe Glu Met Leu Asp Asp His
Gln Gly Gly Gly His Glu Met Glu Glu 85 90 95 Glu Glu Glu Glu Glu
Glu Glu Asn Gly Asp Arg Gln Gly Lys Ala Gly 100 105 110 Gly Gln Pro
Gly Ser Gln Ala Leu Ala Gly Asp Arg Leu Ile Pro Ser 115 120 125 Pro
Ser Leu Glu Glu Thr His Lys Leu Arg Pro Thr Thr Leu His Val 130 135
140 Thr Thr Leu Gly Ala Gln Asp Ser Leu Trp Asn Asn Asn Gly Gly Phe
145 150 155 160 Thr Ser Ala Tyr Pro Ser Ser Trp Gln Glu Thr Val Leu
Ala Ser Pro 165 170 175 Ala Gln Glu Pro Leu Lys Glu Asp Pro Ala Pro
Leu Leu Pro Ala Glu 180 185 190 Glu Phe Arg His Glu Val Gln Ser Leu
Ala Arg Gly Gly Cys Asp Cys 195 200 205 Glu Gly Asn Gln Pro His Glu
Pro Pro Ala Ser Ser Gly Gly Ala Ile 210 215 220 Pro Ser Ser Asp Pro
Gly Ile Glu Ala Lys Leu Arg Ser His Ser Ser 225 230 235 240 Gly Gly
His Leu Gly Arg Arg Ser Ser Gln Glu Leu Ser Met Pro Gly 245 250 255
Ser Asp Ser Glu Asp Ala Gly Asn Ala Arg Leu Gly Arg Met Ile Ser 260
265 270 Ser Gln Ser Glu Thr Glu Leu Glu Leu Ser Ser Arg Gly Gly Ser
Ser 275 280 285 Ser Gly Arg Ser Ser Ser Leu Thr Asn Ser Ile Glu Glu
Ala Ser Thr 290 295 300 Pro Ala Ser Glu Pro Glu Pro Glu Pro Val Pro
Leu His Glu Pro Pro 305 310 315 320 Arg Arg Pro Trp Phe Leu Pro Val
Gly Gln Asp Asp Thr Tyr Ser Glu 325 330 335 Tyr Glu Ser Gly Ser Glu
Ser Ala Pro Asp Leu Ser Glu Asp Ala Asp 340 345 350 Ser Asp Trp Leu
Leu Ser Asn Leu Val Ser Arg Glu Ile Ser Glu Gly 355 360 365 Ser Ser
Pro Ile Arg Phe Pro Gly Gln Cys Leu Ser Pro Ala Pro Gly 370 375 380
Leu Pro Glu Glu Ala Ala Ser Gln Ala His Ser Val Pro Gln Asp Cys 385
390 395 400 Gln Asp Pro Ile Ala Gly Pro His Val Glu Leu Val Asp Lys
Asp Thr 405 410 415 Leu Cys Gly Pro Pro Pro Pro Leu Pro Ala Ala Pro
Arg Leu Gly Pro 420 425 430 Ala Met Pro Gly Pro Cys Leu Phe Leu Ser
Asn Asn Thr Arg Asp Thr 435 440 445 Ile Thr Pro Leu Trp Gln Thr Pro
Gly Arg Thr Ala Arg Pro Gly Ser 450 455 460 Ser Cys Ser Ala Ala Cys
Ser Glu Glu Thr Glu Glu Asp Glu Glu Glu 465 470 475 480 Asp Glu Glu
Val Glu Glu Asp Ala Glu Asp Ser Val Val Trp Pro Gly 485 490 495 Ser
Arg Thr Thr Gly Ser Thr Tyr Pro Leu Asp Ala Ser Leu Val Tyr 500 505
510 Asp Asp Val Lys Tyr Thr Leu Val Val Asp Glu Glu Thr Gln Leu Glu
515 520 525 Leu Val Ser Leu Arg Gly Cys Ala Gly Leu Gly Asn Asp Ser
Glu His 530 535 540 Asp Ser Ser Cys Glu Ala Ser Glu Glu Ile Ala Gly
Ala Thr Leu Leu 545 550 555 560 Gly Ser Asp Lys Val Pro Glu Asp Ala
Ser Pro Asp Ser Leu Asp Leu 565 570 575 Thr Phe Ser Lys Lys Phe Leu
Met Val Phe Val Asn Ser Thr Ser Arg 580 585 590 Ser Asn Ser Thr Glu
Ser Phe Gly Leu Phe Ser Gln Val Xaa Asn Gly 595 600 605 Glu Glu Arg
Glu Gln Arg His Arg Ala Val Phe Arg Phe Ile Pro Ser 610 615 620 His
Pro Asp Glu Leu Glu Leu Asp Val Thr Asp Pro Val Leu Val Glu 625 630
635 640 Ala Glu Glu Val Asp Phe Trp Phe Arg Gly Phe Asn Met Trp Thr
Gly 645 650 655 Glu Arg Gly Val Phe Pro Ala Tyr Tyr Ala His Ala Val
Pro Gly Pro 660 665 670 Ala Ala Asp Leu Leu Gly Ser Lys Arg Ser Pro
Asp Trp Val Asp Arg 675 680 685 Phe Asp Val Gln Phe Glu Gly Ser Val
Glu Val Pro Cys His Gln Phe 690 695 700 Asn Gly Ile Leu Cys Ala Ala
Met Gln Gly Ile Ala Thr Ala Arg Lys 705 710 715 720 Leu Thr Val Ile
Leu Arg Pro Pro Ala Ser Cys Asp Leu Lys Ile Ser 725 730 735 Leu Arg
Gly Val Lys Leu Ser Met Ser Gly Gly Gly Pro Glu Phe Gln 740 745 750
Arg Asn Ser His Phe Phe Gln Met Lys Asn Ile Gln Phe Cys Gly Cys 755
760 765 His Pro Arg Asn Ser Arg Tyr Phe Gly Phe Ile Thr Lys His Pro
Ser 770 775 780 Leu Ser Arg Phe Ala Cys His Val Phe Thr Ser Gln Glu
Ser Met Arg 785 790 795 800 Pro Val Ala Val Ser Val Gly Arg Ala Phe
Leu Glu Tyr Trp Gln Glu 805 810 815 His Leu Ala Phe Ala Cys Pro Tyr
Glu Asp Ile Tyr Leu Glu 820 825 830 35 830 PRT Artificial Sequence
Description of Artificial Sequence Synthetic Sequence 35 Met Ala
Asp Arg Asp Glu Met Phe Ser Leu Ser Thr Phe His Glu Leu 1 5 10 15
Ser Pro Pro Gly Cys Arg Pro Pro Phe Asp Ile Ser Leu Glu Glu Phe 20
25 30 Asp Asp Gly Asp Leu Ser Glu Ile Thr Asp Asp Cys His Leu Gly
Leu 35 40 45 Ser Tyr Asp Ser Asp His Ile Glu Lys Asp Ser Leu Ser
Leu Gly Arg 50 55 60 Lys Glu Gln Pro His Pro Ile Cys Ser Phe Leu
Asp Asp Phe Gln Glu 65 70 75 80 Phe Glu Met Ile Met Asp His Gln Gly
Gly Gly His Glu Glu Asn Glu 85 90 95 Glu Glu Glu Glu Glu Glu Glu
Asp Gln Asp Arg Gln Gly Lys Ala Gly 100 105 110 Gly Gly Arg Gly Ser
Gln Ala Leu Ala Gly Asp Ser Ser Ile Pro Ser 115 120 125 Pro Ser Leu
Glu Glu Ser Thr Lys Leu Arg Pro Thr Thr Leu His Leu 130 135 140 Val
Thr Leu Gly Ala Gln Asp Ser Leu Asn Trp Asn Asn Gly Gly Phe 145 150
155 160 Thr Ser Ala Pro Tyr Ser Ser Trp Gln Glu Thr Val Leu Arg Ala
Pro 165 170 175 Ala Gln Glu Pro Leu Lys Glu Leu Asp Ala Pro Leu Leu
Pro Ala Glu 180 185 190 Glu Glu Glu His Glu Val Gln Ser Leu Ala Arg
Pro Phe Cys Asp Cys 195 200 205 Glu Gly Asn Gln Pro Pro Gly Pro Pro
Ala Ser Ser Gly Gly Ala Ser 210 215 220 His Ser Ser Asp Pro Gly Ile
Glu Ala Asp Ile Arg Ser His Ser Ser 225 230 235 240 Gly Gly His Glu
Lys Arg Arg Ser Ser Gln Glu Leu Ser Ser Leu Gly 245 250 255 Ser Asp
Ser Glu Asp Ala Gly Gly Met Arg Leu Gly Arg Met Ile Ser 260 265 270
Ser Ile Asn Glu Thr Glu Leu Glu Leu Ser Ser Asp Gln Gly Ser Ser 275
280 285 Ser Gly Arg Ser Ser His Arg Thr Asn Ser Ile Glu Glu Ala Ser
Ser 290 295 300 Ser Ala Ser Glu Pro Glu Pro Glu Pro Glu Thr Leu His
Glu Pro Pro 305 310 315 320 Arg Arg Pro Ala Val Leu Pro Val Gly Gln
Asp Asp Thr Asn Trp Glu 325 330 335 Tyr Glu Ser Gly Ser Glu Ser Glu
Tyr Asp Leu Ser Glu Asp Ala Asp 340 345 350 Ser Pro Ala Leu Leu Ser
Asn Leu Val Ser Arg Met Asp Ser Glu Gly 355 360 365 Ser Ser Pro Ile
Arg Cys Glu Gly Gln Cys Leu Ser Pro Ala Pro Arg 370 375 380 Phe Pro
Glu Glu Ala Ala Ser Gln Ala Asn Gly Val Pro Gln Asp Cys 385 390 395
400 Gln Asp Pro Glu His Gly Pro His Val Glu Leu Val Asp Met Ile Thr
405 410 415 Leu Cys Gly Pro Pro Pro Pro Ala Lys Ala Ala Pro Arg Leu
Gly Pro 420 425 430 Ala Gln Leu Gly Pro Cys Leu Phe Leu Ser Asn Pro
Met Arg Asp Thr 435 440 445 Ile Thr Pro Leu Trp Ala Asn Pro Gly Arg
Thr Ala Arg Pro Gly Arg 450 455 460 Gln Cys Ser Ala Ala Cys Ser Glu
Glu Glu Arg Glu Asp Glu Glu Glu 465 470 475 480 Asp Glu Glu Asp Ser
Glu Asp Ala Glu Asp Ser Val Val Pro Thr Gly 485 490 495 Ser Arg Thr
Thr Gly Ser Thr Ala Val Leu Asp Ala Ser Leu Val Tyr 500 505 510 Asp
Ala Trp Lys Tyr Thr Leu Val Val Asp Glu His Tyr Gln Leu Glu 515 520
525 Leu Val Ser Leu Arg Arg Ala Ala Gly Leu Gly Asn Asp Ser Glu Glu
530 535 540 Glu Ser Ser Cys Glu Ala Ser Glu Glu Glu Phe Gly Ala Thr
Leu Leu 545 550 555 560 Gly Ser Asp Gln Gly Pro Glu Asp Ala Ser Pro
Asp Ser Pro His Leu 565 570 575 Thr Phe Ser Lys Lys Phe Leu Asn Ile
Phe Val Asn Ser Thr Ser Arg 580 585 590 Ser Ser Lys Thr Glu Ser Phe
Gly Leu Phe Ser Cys Leu Xaa Asn Gly 595 600 605 Glu Glu Arg Glu Gln
Thr Met Arg Ala Val Phe Arg Phe Ile Pro Arg 610 615 620 Asn Pro Asp
Glu Leu Glu Leu Asp Val Asp Gln Pro Val Leu Val Glu 625 630 635 640
Ala Glu Glu Asp Arg Phe Trp Phe Arg Gly Phe Asn Met Arg Ser Gly 645
650 655 Glu Arg Gly Val Phe Pro Ala Phe Thr Ala His Ala Val Pro Gly
Pro 660 665 670 Ala Lys Val Leu Leu Gly Ser Lys Arg Ser Pro Cys Tyr
Val Asp Arg 675 680 685 Phe Asp Val Gln Phe Leu Ala Ser Val Glu Val
Pro Cys His Gln Gly 690 695 700 Asp Gly Ile Leu Cys Ala Ala Met Gln
Lys Glu Ala Thr Ala Arg Lys 705 710 715 720 Leu Thr Val His Phe Arg
Pro Pro Ala Ser Cys Asp Leu Glu Gly Ser 725 730 735 Leu Arg Gly Val
Lys Leu Ser Leu His Gly Gly Gly Pro Glu Phe Gln 740 745 750 Arg Cys
Ile His Phe Phe Gln Met Lys Asn Ile Ser Lys Cys Gly Cys 755 760 765
His Pro Arg Asn Ser Cys Leu Phe Gly Phe Ile Thr Lys His Pro Leu 770
775 780 Met Ser Arg Phe Ala Cys His Val Phe Val Asn Gln Glu Ser Met
Arg 785 790 795 800 Pro Val Ala Arg Gln Val Gly Arg Ala Phe Leu Glu
Tyr Tyr Arg Glu 805 810 815 His Leu Ala Phe Ala Cys Pro Thr Ser Asp
Ile Tyr Leu Glu 820 825 830 36 830 PRT Artificial Sequence
Description of Artificial Sequence Synthetic Sequence 36 Met Ala
Asp Arg Ala Ala Met Phe Ser Leu Ser Thr Phe His Ser Asp 1 5 10 15
Ser Pro Pro Gly Cys Arg Pro Pro Gln Glu Ile Ser Leu Glu Glu Phe 20
25 30 Asp Asp Glu Phe Leu Ser Glu Ile Thr Asp Asp Cys Gly Gly Gly
Leu 35 40 45 Ser Tyr Asp Ser Asp His Cys His Lys Asp Ser Leu Ser
Leu Gly Arg 50 55 60 Ser Ile Gln Pro His Pro Ile Cys Ser Phe Gln
Lys Asp Phe Gln Glu 65 70 75 80 Phe Glu Met Ile Asp Leu His Gln Gly
Gly Gly His Glu Glu Glu Met 85 90 95 Glu Glu Glu Glu Glu Glu Glu
Asp Gly Asn Arg Gln Gly Lys Ala Gly 100 105 110 Gly Gly Pro Gln Ser
Gln Ala Leu Ala Gly Asp Ser Leu Arg Pro Ser 115 120 125 Pro Ser Leu
Glu Glu Ser His Ser Leu Arg Pro Thr Thr Leu His Leu 130 135 140 Thr
Val Leu Gly Ala Gln Asp Ser Leu Asn Asn Trp Asn Gly Gly Phe 145 150
155 160 Thr Ser Ala Pro Pro Tyr Ser Trp Gln Glu Thr Val Leu Arg Ser
Ala 165 170 175 Ala Gln Glu Pro Leu Lys Glu Leu Pro Asp Pro Leu Leu
Pro Ala Glu 180 185 190 Glu Glu Arg Glu Glu Val Gln Ser Leu Ala Arg
Pro Gly Phe Asp Cys 195 200 205 Glu Gly Asn Gln Pro Pro Glu Gly Pro
Ala Ser Ser Gly Gly Ala Ser 210 215 220 Pro His Ser Asp Pro Gly Ile
Glu Ala Asp Leu Ile Ser His Ser Ser 225 230 235 240 Gly Gly His Glu
Gly Lys Arg Ser Ser Gln Glu Leu Ser Ser Pro Leu 245 250 255 Ser Asp
Ser Glu Asp Ala Gly Gly Ala Met Leu Gly Arg Met Ile Ser 260 265 270
Ser Ile Ser Asn Thr Glu Leu Glu Leu Ser Ser Asp Gly Gln Ser Ser 275
280 285 Ser Gly Arg Ser Ser His Leu Arg Asn Ser Ile Glu Glu Ala
Ser
Ser 290 295 300 Pro Ser Ser Glu Pro Glu Pro Glu Pro Glu Pro Thr His
Glu Pro Pro 305 310 315 320 Arg Arg Pro Ala Phe Val Pro Val Gly Gln
Asp Asp Thr Asn Ser Trp 325 330 335 Tyr Glu Ser Gly Ser Glu Ser Glu
Pro Tyr Leu Ser Glu Asp Ala Asp 340 345 350 Ser Pro Trp Ala Leu Ser
Asn Leu Val Ser Arg Met Ile Asp Glu Gly 355 360 365 Ser Ser Pro Ile
Arg Cys Pro Glu Gln Cys Leu Ser Pro Ala Pro Arg 370 375 380 Leu Phe
Glu Glu Ala Ala Ser Gln Ala Asn Ser Gly Pro Gln Asp Cys 385 390 395
400 Gln Asp Pro Glu Ala His Pro His Val Glu Leu Val Asp Met Asp Ile
405 410 415 Leu Cys Gly Pro Pro Pro Pro Ala Pro Lys Ala Pro Arg Leu
Gly Pro 420 425 430 Ala Gln Pro Leu Pro Cys Leu Phe Leu Ser Asn Pro
Thr Met Asp Thr 435 440 445 Ile Thr Pro Leu Trp Ala Thr Asn Gly Arg
Thr Ala Arg Pro Gly Arg 450 455 460 Ser Gln Ser Ala Ala Cys Ser Glu
Glu Glu Glu Arg Asp Glu Glu Glu 465 470 475 480 Asp Glu Glu Asp Glu
Ser Asp Ala Glu Asp Ser Val Val Pro Pro Thr 485 490 495 Ser Arg Thr
Thr Gly Ser Thr Ala Pro Val Asp Ala Ser Leu Val Tyr 500 505 510 Asp
Ala Val Trp Tyr Thr Leu Val Val Asp Glu His Thr Tyr Leu Glu 515 520
525 Leu Val Ser Leu Arg Arg Cys Asp Gly Leu Gly Asn Asp Ser Glu Glu
530 535 540 Asp Glu Ser Cys Glu Ala Ser Glu Glu Glu Ala Phe Ala Thr
Leu Leu 545 550 555 560 Gly Ser Asp Gln Val Gly Glu Asp Ala Ser Pro
Asp Ser Pro Asp His 565 570 575 Thr Phe Ser Lys Lys Phe Leu Asn Val
Ile Val Asn Ser Thr Ser Arg 580 585 590 Ser Ser Ser Lys Glu Ser Phe
Gly Leu Phe Ser Cys Val Leu Asn Gly 595 600 605 Glu Glu Arg Glu Gln
Thr His Met Ala Val Phe Arg Phe Ile Pro Arg 610 615 620 His Asn Asp
Glu Leu Glu Leu Asp Val Asp Asp Gln Val Leu Val Glu 625 630 635 640
Ala Glu Glu Asp Asp Arg Trp Phe Arg Gly Phe Asn Met Arg Thr Ser 645
650 655 Glu Arg Gly Val Phe Pro Ala Phe Tyr Thr His Ala Val Pro Gly
Pro 660 665 670 Ala Lys Asp Val Leu Gly Ser Lys Arg Ser Pro Cys Trp
Trp Asp Arg 675 680 685 Phe Asp Val Gln Phe Leu Gly Tyr Val Glu Val
Pro Cys His Gln Gly 690 695 700 Asn Ala Ile Leu Cys Ala Ala Met Gln
Lys Ile Asp Thr Ala Arg Lys 705 710 715 720 Leu Thr Val His Leu Glu
Pro Pro Ala Ser Cys Asp Leu Glu Ile Phe 725 730 735 Leu Arg Gly Val
Lys Leu Ser Leu Ser His Gly Gly Pro Glu Phe Gln 740 745 750 Arg Cys
Ser Ile Phe Phe Gln Met Lys Asn Ile Ser Phe Lys Gly Cys 755 760 765
His Pro Arg Asn Ser Cys Tyr Leu Gly Phe Ile Thr Lys His Pro Leu 770
775 780 Leu Met Arg Phe Ala Cys His Val Phe Val Ser Asn Glu Ser Met
Arg 785 790 795 800 Pro Val Ala Arg Ser Gln Gly Arg Ala Phe Leu Glu
Tyr Tyr Gln Arg 805 810 815 His Leu Ala Phe Ala Cys Pro Thr Glu Ser
Ile Tyr Leu Glu 820 825 830 37 830 PRT Artificial Sequence
Description of Artificial Sequence Synthetic Sequence 37 Met Ala
Asp Arg Ala Glu Ala Phe Ser Leu Ser Thr Phe His Ser Leu 1 5 10 15
Asp Pro Pro Gly Cys Arg Pro Pro Gln Asp Glu Ser Leu Glu Glu Phe 20
25 30 Asp Asp Glu Asp Phe Ser Glu Ile Thr Asp Asp Cys Gly Leu His
Leu 35 40 45 Ser Tyr Asp Ser Asp His Cys Glu Ile Asp Ser Leu Ser
Leu Gly Arg 50 55 60 Ser Glu Lys Pro His Pro Ile Cys Ser Phe Gln
Asp Leu Phe Gln Glu 65 70 75 80 Phe Glu Met Ile Asp Asp Met Gln Gly
Gly Gly His Glu Glu Glu Glu 85 90 95 Asn Glu Glu Glu Glu Glu Glu
Asp Gly Asp Gln Gln Gly Lys Ala Gly 100 105 110 Gly Gly Pro Gly Arg
Gln Ala Leu Ala Gly Asp Ser Leu Ile Ser Ser 115 120 125 Pro Ser Leu
Glu Glu Ser His Lys Thr Arg Pro Thr Thr Leu His Leu 130 135 140 Thr
Thr Val Gly Ala Gln Asp Ser Leu Asn Asn Asn Trp Gly Gly Phe 145 150
155 160 Thr Ser Ala Pro Pro Ser Tyr Trp Gln Glu Thr Val Leu Arg Ser
Pro 165 170 175 Asp Gln Glu Pro Leu Lys Glu Leu Pro Ala Glu Leu Leu
Pro Ala Glu 180 185 190 Glu Glu Arg His Phe Val Gln Ser Leu Ala Arg
Pro Gly Cys Gly Cys 195 200 205 Glu Gly Asn Gln Pro Pro Glu Pro His
Ala Ser Ser Gly Gly Ala Ser 210 215 220 Pro Ser Ile Asp Pro Gly Ile
Glu Ala Asp Leu Arg Lys His Ser Ser 225 230 235 240 Gly Gly His Glu
Gly Arg Leu Ser Ser Gln Glu Leu Ser Ser Pro Gly 245 250 255 Met Asp
Ser Glu Asp Ala Gly Gly Ala Arg Asn Gly Arg Met Ile Ser 260 265 270
Ser Ile Ser Glu Gln Glu Leu Glu Leu Ser Ser Asp Gly Gly Arg Ser 275
280 285 Ser Gly Arg Ser Ser His Leu Thr Ser Ser Ile Glu Glu Ala Ser
Ser 290 295 300 Pro Ala Thr Glu Pro Glu Pro Glu Pro Glu Pro Leu Val
Glu Pro Pro 305 310 315 320 Arg Arg Pro Ala Phe Leu Trp Val Gly Gln
Asp Asp Thr Asn Ser Glu 325 330 335 Ala Glu Ser Gly Ser Glu Ser Glu
Pro Asp Asp Ser Glu Asp Ala Asp 340 345 350 Ser Pro Trp Leu Glu Ser
Asn Leu Val Ser Arg Met Ile Ser Phe Gly 355 360 365 Ser Ser Pro Ile
Arg Cys Pro Gly Gly Cys Leu Ser Pro Ala Pro Arg 370 375 380 Leu Pro
His Glu Ala Ala Ser Gln Ala Asn Ser Val Ile Gln Asp Cys 385 390 395
400 Gln Asp Pro Glu Ala Gly Lys His Val Glu Leu Val Asp Met Asp Thr
405 410 415 Met Cys Gly Pro Pro Pro Pro Ala Pro Ala Asn Pro Arg Leu
Gly Pro 420 425 430 Ala Gln Pro Gly Gln Cys Leu Phe Leu Ser Asn Pro
Thr Arg Arg Thr 435 440 445 Ile Thr Pro Leu Trp Ala Thr Pro Ser Arg
Thr Ala Arg Pro Gly Arg 450 455 460 Ser Cys Thr Ala Ala Cys Ser Glu
Glu Glu Glu Glu Val Glu Glu Glu 465 470 475 480 Asp Glu Glu Asp Glu
Glu Trp Ala Glu Asp Ser Val Val Pro Pro Gly 485 490 495 Tyr Arg Thr
Thr Gly Ser Thr Ala Pro Leu Ala Ala Ser Leu Val Tyr 500 505 510 Asp
Ala Val Lys Asp Thr Leu Val Val Asp Glu His Thr Gln Glu Glu 515 520
525 Leu Val Ser Leu Arg Arg Cys Ala Phe Leu Gly Asn Asp Ser Glu Glu
530 535 540 Asp Ser Gly Cys Glu Ala Ser Glu Glu Glu Ala Gly His Thr
Leu Leu 545 550 555 560 Gly Ser Asp Gln Val Pro Ile Asp Ala Ser Pro
Asp Ser Pro Asp Leu 565 570 575 Lys Phe Ser Lys Lys Phe Leu Asn Val
Phe Leu Asn Ser Thr Ser Arg 580 585 590 Ser Ser Ser Thr Met Ser Phe
Gly Leu Phe Ser Cys Val Xaa Gln Gly 595 600 605 Glu Glu Arg Glu Gln
Thr His Arg Arg Val Phe Arg Phe Ile Pro Arg 610 615 620 His Pro Ser
Glu Leu Glu Leu Asp Val Asp Asp Pro Thr Leu Val Glu 625 630 635 640
Ala Glu Glu Asp Asp Phe Val Phe Arg Gly Phe Asn Met Arg Thr Gly 645
650 655 Trp Arg Gly Val Phe Pro Ala Phe Tyr Ala Tyr Ala Val Pro Gly
Pro 660 665 670 Ala Lys Asp Leu Ala Gly Ser Lys Arg Ser Pro Cys Trp
Val Glu Arg 675 680 685 Phe Asp Val Gln Phe Leu Gly Ser Phe Glu Val
Pro Cys His Gln Gly 690 695 700 Asn Gly Gly Leu Cys Ala Ala Met Gln
Lys Ile Ala His Ala Arg Lys 705 710 715 720 Leu Thr Val His Leu Arg
Ile Pro Ala Ser Cys Asp Leu Glu Ile Ser 725 730 735 Lys Arg Gly Val
Lys Leu Ser Leu Ser Gly Leu Gly Pro Glu Phe Gln 740 745 750 Arg Cys
Ser His Met Phe Gln Met Lys Asn Ile Ser Phe Cys Asn Cys 755 760 765
His Pro Arg Asn Ser Cys Tyr Phe Gln Phe Ile Thr Lys His Pro Leu 770
775 780 Leu Ser Ser Phe Ala Cys His Val Phe Val Ser Gln Thr Ser Met
Arg 785 790 795 800 Pro Val Ala Arg Ser Val Val Arg Ala Phe Leu Glu
Tyr Tyr Gln Glu 805 810 815 Trp Leu Ala Phe Ala Cys Pro Thr Glu Asp
Tyr Tyr Leu Glu 820 825 830 38 830 PRT Artificial Sequence
Description of Artificial Sequence Synthetic Sequence 38 Met Ala
Asp Arg Ala Glu Met Ala Ser Leu Ser Thr Phe His Ser Leu 1 5 10 15
Ser Asp Pro Gly Cys Arg Pro Pro Gln Asp Ile Glu Leu Glu Glu Phe 20
25 30 Asp Asp Glu Asp Leu Phe Glu Ile Thr Asp Asp Cys Gly Leu Gly
Gly 35 40 45 Ser Tyr Asp Ser Asp His Cys Glu Lys His Ser Leu Ser
Leu Gly Arg 50 55 60 Ser Glu Gln Ile His Pro Ile Cys Ser Phe Gln
Asp Asp Lys Gln Glu 65 70 75 80 Phe Glu Met Ile Asp Asp His Leu Gly
Gly Gly His Glu Glu Glu Glu 85 90 95 Glu Met Glu Glu Glu Glu Glu
Asp Gly Asp Arg Asn Gly Lys Ala Gly 100 105 110 Gly Gly Pro Gly Ser
Gln Ala Leu Ala Gly Asp Ser Leu Ile Pro Arg 115 120 125 Pro Ser Leu
Glu Glu Ser His Lys Leu Ser Pro Thr Thr Leu His Leu 130 135 140 Thr
Thr Leu Thr Ala Gln Asp Ser Leu Asn Asn Asn Asn Val Gly Phe 145 150
155 160 Thr Ser Ala Pro Pro Ser Ser Trp Gln Glu Thr Val Leu Arg Ser
Pro 165 170 175 Ala Tyr Glu Pro Leu Lys Glu Leu Pro Ala Pro Ala Leu
Pro Ala Glu 180 185 190 Glu Glu Arg His Glu Asp Gln Ser Leu Ala Arg
Pro Gly Cys Asp Glu 195 200 205 Glu Gly Asn Gln Pro Pro Glu Pro Pro
Phe Ser Ser Gly Gly Ala Ser 210 215 220 Pro Ser Ser Gly Pro Gly Ile
Glu Ala Asp Leu Arg Ser Ile Ser Ser 225 230 235 240 Gly Gly His Glu
Gly Arg Arg Lys Ser Gln Glu Leu Ser Ser Pro Gly 245 250 255 Ser Leu
Ser Glu Asp Ala Gly Gly Ala Arg Leu Met Arg Met Ile Ser 260 265 270
Ser Ile Ser Glu Thr Asn Leu Glu Leu Ser Ser Asp Gly Gly Ser Gln 275
280 285 Ser Gly Arg Ser Ser His Leu Thr Asn Arg Ile Glu Glu Ala Ser
Ser 290 295 300 Pro Ala Ser Ser Pro Glu Pro Glu Pro Glu Pro Leu His
Thr Pro Pro 305 310 315 320 Arg Arg Pro Ala Phe Leu Pro Trp Gly Gln
Asp Asp Thr Asn Ser Glu 325 330 335 Tyr Tyr Ser Gly Ser Glu Ser Glu
Pro Asp Leu Ala Glu Asp Ala Asp 340 345 350 Ser Pro Trp Leu Leu Asp
Asn Leu Val Ser Arg Met Ile Ser Glu Glu 355 360 365 Ser Ser Pro Ile
Arg Cys Pro Gly Gln Phe Leu Ser Pro Ala Pro Arg 370 375 380 Leu Pro
Glu Gly Ala Ala Ser Gln Ala Asn Ser Val Pro His Asp Cys 385 390 395
400 Gln Asp Pro Glu Ala Gly Pro Ile Val Glu Leu Val Asp Met Asp Thr
405 410 415 Leu Lys Gly Pro Pro Pro Pro Ala Pro Ala Ala Leu Arg Leu
Gly Pro 420 425 430 Ala Gln Pro Gly Pro Met Leu Phe Leu Ser Asn Pro
Thr Arg Asp Asn 435 440 445 Ile Thr Pro Leu Trp Ala Thr Pro Gly Gln
Thr Ala Arg Pro Gly Arg 450 455 460 Ser Cys Ser Arg Ala Cys Ser Glu
Glu Glu Glu Glu Asp Ser Glu Glu 465 470 475 480 Asp Glu Glu Asp Glu
Glu Asp Thr Glu Asp Ser Val Val Pro Pro Gly 485 490 495 Ser Val Thr
Thr Gly Ser Thr Ala Pro Leu Asp Trp Ser Leu Val Tyr 500 505 510 Asp
Ala Val Lys Tyr Tyr Leu Val Val Asp Glu His Thr Gln Leu Ala 515 520
525 Leu Val Ser Leu Arg Arg Cys Ala Gly Asp Gly Asn Asp Ser Glu Glu
530 535 540 Asp Ser Ser Glu Glu Ala Ser Glu Glu Glu Ala Gly Ala Phe
Leu Leu 545 550 555 560 Gly Ser Asp Gln Val Pro Glu Gly Ala Ser Pro
Asp Ser Pro Asp Leu 565 570 575 Thr His Ser Lys Lys Phe Leu Asn Val
Phe Val Ile Ser Thr Ser Arg 580 585 590 Ser Ser Ser Thr Glu Lys Phe
Gly Leu Phe Ser Cys Val Xaa Asn Leu 595 600 605 Glu Glu Arg Glu Gln
Thr His Arg Ala Met Phe Arg Phe Ile Pro Arg 610 615 620 His Pro Asp
Asn Leu Glu Leu Asp Val Asp Asp Pro Val Gln Val Glu 625 630 635 640
Ala Glu Glu Asp Asp Phe Trp Arg Arg Gly Phe Asn Met Arg Thr Gly 645
650 655 Glu Ser Gly Val Phe Pro Ala Phe Tyr Ala His Thr Val Pro Gly
Pro 660 665 670 Ala Lys Asp Leu Leu Val Ser Lys Arg Ser Pro Cys Trp
Val Asp Trp 675 680 685 Phe Asp Val Gln Phe Leu Gly Ser Val Tyr Val
Pro Cys His Gln Gly 690 695 700 Asn Gly Ile Ala Cys Ala Ala Met Gln
Lys Ile Ala Thr Asp Arg Lys 705 710 715 720 Leu Thr Val His Leu Arg
Pro Glu Ala Ser Cys Asp Leu Glu Ile Ser 725 730 735 Leu Phe Gly Val
Lys Leu Ser Leu Ser Gly Gly His Pro Glu Phe Gln 740 745 750 Arg Cys
Ser His Phe Ile Gln Met Lys Asn Ile Ser Phe Cys Gly Lys 755 760 765
His Pro Arg Asn Ser Cys Tyr Phe Gly Leu Ile Thr Lys His Pro Leu 770
775 780 Leu Ser Arg Met Ala Cys His Val Phe Val Ser Gln Glu Asn Met
Arg 785 790 795 800 Pro Val Ala Arg Ser Val Gly Gln Ala Phe Leu Glu
Tyr Tyr Gln Glu 805 810 815 His Arg Ala Phe Ala Cys Pro Thr Glu Asp
Ile Ser Leu Glu 820 825 830 39 830 PRT Artificial Sequence
Description of Artificial Sequence Synthetic Sequence 39 Met Ala
Asp Arg Ala Glu Met Phe Ala Leu Ser Thr Phe His Ser Leu 1 5 10 15
Ser Pro Asp Gly Cys Arg Pro Pro Gln Asp Ile Ser Glu Glu Glu Phe 20
25 30 Asp Asp Glu Asp Leu Ser Phe Ile Thr Asp Asp Cys Gly Leu Gly
Leu 35 40 45 Gly Tyr Asp Ser Asp His Cys Glu Lys Asp His Leu Ser
Leu Gly Arg 50 55 60 Ser Glu Gln Pro Ile Pro Ile Cys Ser Phe Gln
Asp Asp Phe Lys Glu 65 70 75 80 Phe Glu Met Ile Asp Asp His Gln Leu
Gly Gly His Glu Glu Glu Glu 85 90 95 Glu Glu Met Glu Glu Glu Glu
Asp Gly Asp Arg Gln Asn Lys Ala Gly 100 105 110 Gly Gly Pro Gly Ser
Gln Gln Leu Ala Gly Asp Ser Leu Ile Pro Ser 115 120 125 Arg Ser Leu
Glu Glu Ser His Lys Leu Arg Ser Thr Thr Leu His Leu 130 135 140 Thr
Thr Leu Gly Thr Gln Asp Ser Leu Asn Asn Asn Asn Gly Val Phe 145 150
155 160 Thr Ser Ala Pro Pro Ser Ser Trp Trp Glu Thr Val Leu Arg Ser
Pro 165 170 175 Ala Gln Tyr Pro Leu Lys Glu Leu Pro Ala Pro Leu Ala
Pro Ala Glu 180 185 190 Glu Glu Arg His Glu Val Asp Ser Leu Ala Arg
Pro Gly Cys Asp Cys 195 200 205 Phe Gly Asn Gln Pro Pro Glu Pro Pro
Ala Gly
Ser Gly Gly Ala Ser 210 215 220 Pro Ser Ser Asp His Gly Ile Glu Ala
Asp Leu Arg Ser His Ile Ser 225 230 235 240 Gly Gly His Glu Gly Arg
Arg Ser Lys Gln Glu Leu Ser Ser Pro Gly 245 250 255 Ser Asp Leu Glu
Asp Ala Gly Gly Ala Arg Leu Gly Met Met Ile Ser 260 265 270 Ser Ile
Ser Glu Thr Glu Asn Glu Leu Ser Ser Asp Gly Gly Ser Ser 275 280 285
Gln Gly Arg Ser Ser His Leu Thr Asn Ser Arg Glu Glu Ala Ser Ser 290
295 300 Pro Ala Ser Glu Ser Glu Pro Glu Pro Glu Pro Leu His Glu Thr
Pro 305 310 315 320 Arg Arg Pro Ala Phe Leu Pro Val Val Gln Asp Asp
Thr Asn Ser Glu 325 330 335 Tyr Glu Trp Gly Ser Glu Ser Glu Pro Asp
Leu Ser Tyr Asp Ala Asp 340 345 350 Ser Pro Trp Leu Leu Ser Ala Leu
Val Ser Arg Met Ile Ser Glu Gly 355 360 365 Asp Ser Pro Ile Arg Cys
Pro Gly Gln Cys Glu Ser Pro Ala Pro Arg 370 375 380 Leu Pro Glu Glu
Phe Ala Ser Gln Ala Asn Ser Val Pro Gln Gly Cys 385 390 395 400 Gln
Asp Pro Glu Ala Gly Pro His His Glu Leu Val Asp Met Asp Thr 405 410
415 Leu Cys Ile Pro Pro Pro Pro Ala Pro Ala Ala Pro Lys Leu Gly Pro
420 425 430 Ala Gln Pro Gly Pro Cys Met Phe Leu Ser Asn Pro Thr Arg
Asp Thr 435 440 445 Asn Thr Pro Leu Trp Ala Thr Pro Gly Arg Gln Ala
Arg Pro Gly Arg 450 455 460 Ser Cys Ser Ala Arg Cys Ser Glu Glu Glu
Glu Glu Asp Glu Ser Glu 465 470 475 480 Asp Glu Glu Asp Glu Glu Asp
Ala Thr Asp Ser Val Val Pro Pro Gly 485 490 495 Ser Arg Val Thr Gly
Ser Thr Ala Pro Leu Asp Ala Trp Leu Val Tyr 500 505 510 Asp Ala Val
Lys Tyr Thr Tyr Val Val Asp Glu His Thr Gln Leu Glu 515 520 525 Ala
Val Ser Leu Arg Arg Cys Ala Gly Leu Asp Asn Asp Ser Glu Glu 530 535
540 Asp Ser Ser Cys Phe Ala Ser Glu Glu Glu Ala Gly Ala Thr Gly Leu
545 550 555 560 Gly Ser Asp Gln Val Pro Glu Asp His Ser Pro Asp Ser
Pro Asp Leu 565 570 575 Thr Phe Ile Lys Lys Phe Leu Asn Val Phe Val
Asn Lys Thr Ser Arg 580 585 590 Ser Ser Ser Thr Glu Ser Leu Gly Leu
Phe Ser Cys Val Xaa Asn Gly 595 600 605 Met Glu Arg Glu Gln Thr His
Arg Ala Val Asn Arg Phe Ile Pro Arg 610 615 620 His Pro Asp Glu Gln
Glu Leu Asp Val Asp Asp Pro Val Leu Arg Glu 625 630 635 640 Ala Glu
Glu Asp Asp Phe Trp Phe Ser Gly Phe Asn Met Arg Thr Gly 645 650 655
Glu Arg Thr Val Phe Pro Ala Phe Tyr Ala His Ala Trp Pro Gly Pro 660
665 670 Ala Lys Asp Leu Leu Gly Tyr Lys Arg Ser Pro Cys Trp Val Asp
Arg 675 680 685 Ala Asp Val Gln Phe Leu Gly Ser Val Glu Asp Pro Cys
His Gln Gly 690 695 700 Asn Gly Ile Leu Glu Ala Ala Met Gln Lys Ile
Ala Thr Ala Phe Lys 705 710 715 720 Leu Thr Val His Leu Arg Pro Pro
Gly Ser Cys Asp Leu Glu Ile Ser 725 730 735 Leu Arg His Val Lys Leu
Ser Leu Ser Gly Gly Gly Ile Glu Phe Gln 740 745 750 Arg Cys Ser His
Phe Phe Lys Met Lys Asn Ile Ser Phe Cys Gly Cys 755 760 765 Leu Pro
Arg Asn Ser Cys Tyr Phe Gly Phe Met Thr Lys His Pro Leu 770 775 780
Leu Ser Arg Phe Asn Cys His Val Phe Val Ser Gln Glu Ser Gln Arg 785
790 795 800 Pro Val Ala Arg Ser Val Gly Arg Arg Phe Leu Glu Tyr Tyr
Gln Glu 805 810 815 His Leu Ser Phe Ala Cys Pro Thr Glu Asp Ile Tyr
Thr Glu 820 825 830 40 829 PRT Artificial Sequence Description of
Artificial Sequence Synthetic Sequence 40 Met Ala Asp Arg Ala Glu
Met Phe Ser Ala Ser Thr Phe His Ser Leu 1 5 10 15 Ser Pro Pro Asp
Cys Arg Pro Pro Gln Asp Ile Ser Leu Phe Glu Phe 20 25 30 Asp Asp
Glu Asp Leu Ser Glu Gly Thr Asp Asp Cys Gly Leu Gly Leu 35 40 45
Ser His Asp Ser Asp His Cys Glu Lys Asp Ser Ile Ser Leu Gly Arg 50
55 60 Ser Glu Gln Pro His Lys Ile Cys Ser Phe Gln Asp Asp Phe Gln
Leu 65 70 75 80 Phe Glu Met Ile Asp Asp His Gln Gly Met Gly His Glu
Glu Glu Glu 85 90 95 Glu Glu Glu Asn Glu Glu Glu Asp Gly Asp Arg
Gln Gly Gln Ala Gly 100 105 110 Gly Gly Pro Gly Ser Gln Ala Arg Ala
Gly Asp Ser Leu Ile Pro Ser 115 120 125 Pro Thr Leu Glu Glu Ser His
Lys Leu Arg Pro Val Thr Leu His Leu 130 135 140 Thr Thr Leu Gly Ala
Trp Asp Ser Leu Asn Asn Asn Asn Gly Gly Tyr 145 150 155 160 Thr Ser
Ala Pro Pro Ser Ser Trp Gln Ala Thr Val Leu Arg Ser Pro 165 170 175
Ala Gln Glu Asp Leu Lys Glu Leu Pro Ala Pro Leu Leu Glu Ala Glu 180
185 190 Glu Glu Arg His Glu Val Gln Phe Leu Ala Arg Pro Gly Cys Asp
Cys 195 200 205 Glu His Asn Gln Pro Pro Glu Pro Pro Ala Ser Ile Gly
Gly Ala Ser 210 215 220 Pro Ser Ser Asp Pro Lys Ile Glu Ala Asp Leu
Arg Ser His Ser Leu 225 230 235 240 Gly Gly His Glu Gly Arg Arg Ser
Ser Met Glu Leu Ser Ser Pro Gly 245 250 255 Ser Asp Ser Asn Asp Ala
Gly Gly Ala Arg Leu Gly Arg Gln Ile Ser 260 265 270 Ser Ile Ser Glu
Thr Glu Leu Arg Leu Ser Ser Asp Gly Gly Ser Ser 275 280 285 Ser Ser
Arg Ser Ser His Leu Thr Asn Ser Ile Thr Glu Ala Ser Ser 290 295 300
Pro Ala Ser Glu Pro Val Pro Glu Pro Glu Pro Leu His Glu Pro Trp 305
310 315 320 Arg Arg Pro Ala Phe Leu Pro Val Gly Tyr Asp Asp Thr Asn
Ser Glu 325 330 335 Tyr Glu Ser Ala Ser Glu Ser Glu Pro Asp Leu Ser
Glu Glu Ala Asp 340 345 350 Ser Pro Trp Leu Leu Ser Asn Phe Val Ser
Arg Met Ile Ser Glu Gly 355 360 365 Ser Gly Pro Ile Arg Cys Pro Gly
Gln Cys Leu His Pro Ala Pro Arg 370 375 380 Leu Pro Glu Glu Ala Lys
Ser Gln Ala Asn Ser Val Pro Gln Asp Leu 385 390 395 400 Gln Asp Pro
Glu Ala Gly Pro His Val Met Leu Val Asp Met Asp Thr 405 410 415 Leu
Cys Gly Asn Pro Pro Pro Ala Pro Ala Ala Pro Arg Gln Gly Pro 420 425
430 Ala Gln Pro Gly Pro Cys Leu Arg Leu Ser Asn Pro Thr Arg Asp Thr
435 440 445 Ile Ser Pro Leu Trp Ala Thr Pro Gly Arg Thr Thr Arg Pro
Gly Arg 450 455 460 Ser Cys Ser Ala Ala Val Ser Glu Glu Glu Glu Glu
Asp Glu Glu Trp 465 470 475 480 Asp Glu Glu Asp Glu Glu Asp Ala Glu
Tyr Ser Val Val Pro Pro Gly 485 490 495 Ser Arg Thr Ala Gly Ser Thr
Ala Pro Leu Asp Ala Ser Asp Val Tyr 500 505 510 Asp Ala Val Lys Tyr
Thr Leu Glu Val Asp Glu His Thr Gln Leu Glu 515 520 525 Leu Phe Ser
Leu Arg Arg Cys Ala Gly Leu Gly Gly Asp Ser Glu Glu 530 535 540 Asp
Ser Ser Cys Glu His Ser Glu Glu Glu Ala Gly Ala Thr Leu Ile 545 550
555 560 Gly Ser Asp Gln Val Pro Glu Asp Ala Lys Pro Asp Ser Pro Asp
Leu 565 570 575 Thr Phe Ser Leu Lys Phe Leu Asn Val Phe Val Asn Ser
Met Ser Arg 580 585 590 Ser Ser Ser Thr Glu Ser Phe Asn Leu Phe Ser
Cys Val Xaa Asn Gly 595 600 605 Glu Gln Arg Glu Gln Thr His Arg Ala
Val Phe Ser Phe Ile Pro Arg 610 615 620 His Pro Asp Glu Leu Thr Leu
Asp Val Asp Asp Pro Val Leu Val Val 625 630 635 640 Ala Glu Glu Asp
Asp Phe Trp Phe Arg Trp Phe Asn Met Arg Thr Gly 645 650 655 Glu Arg
Gly Tyr Phe Pro Ala Phe Tyr Ala His Ala Val Ala Gly Pro 660 665 670
Ala Lys Asp Leu Leu Gly Ser Asp Arg Ser Pro Cys Trp Val Asp Arg 675
680 685 Phe Glu Val Gln Phe Leu Gly Ser Val Glu Val Phe Cys His Gln
Gly 690 695 700 Asn Gly Ile Leu Cys Gly Ala Met Gln Lys Ile Ala Thr
Ala Arg His 705 710 715 720 Leu Thr Val His Leu Arg Pro Pro Ala Ile
Cys Asp Leu Glu Ile Ser 725 730 735 Leu Arg Gly Lys Leu Ser Leu Ser
Gly Gly Gly Pro Lys Phe Gln Arg 740 745 750 Cys Ser His Phe Phe Gln
Leu Lys Asn Ile Ser Phe Cys Gly Cys His 755 760 765 Met Arg Asn Ser
Cys Tyr Phe Gly Phe Ile Asn Lys His Pro Leu Leu 770 775 780 Ser Arg
Phe Ala Gln His Val Phe Val Ser Gln Glu Ser Met Ser Pro 785 790 795
800 Val Ala Arg Ser Val Gly Arg Ala Thr Leu Glu Tyr Tyr Gln Glu His
805 810 815 Leu Ala Val Ala Cys Pro Thr Glu Asp Ile Tyr Leu Trp 820
825 41 1024 PRT Artificial Sequence Description of Artificial
Sequence Synthetic Sequence 41 Met Val Ala Leu Ser Leu Lys Ile Ser
Ile Gly Asn Val Val Lys Thr 1 5 10 15 Met Gln Phe Glu Pro Ser Thr
Met Val Tyr Asp Ala Cys Arg Ile Ile 20 25 30 Arg Glu Arg Ile Pro
Glu Ala Pro Ala Gly Pro Pro Ser Asp Phe Gly 35 40 45 Leu Phe Leu
Ser Asp Asp Asp Pro Lys Lys Gly Ile Trp Leu Glu Ala 50 55 60 Gly
Lys Ala Leu Asp Tyr Tyr Met Leu Arg Asn Gly Asp Thr Met Glu 65 70
75 80 Tyr Arg Lys Lys Gln Arg Pro Leu Lys Ile Arg Met Leu Asp Gly
Thr 85 90 95 Val Lys Thr Ile Met Val Asp Asp Ser Lys Thr Val Thr
Asp Met Leu 100 105 110 Met Thr Ile Cys Ala Arg Ile Gly Ile Thr Asn
His Asp Glu Tyr Ser 115 120 125 Leu Val Arg Glu Leu Met Glu Glu Lys
Lys Glu Glu Ile Thr Gly Thr 130 135 140 Leu Arg Lys Asp Lys Thr Leu
Leu Arg Asp Glu Lys Lys Met Glu Lys 145 150 155 160 Leu Lys Gln Lys
Leu His Thr Asp Asp Glu Leu Asn Trp Leu Asp His 165 170 175 Gly Arg
Thr Leu Arg Glu Gln Gly Val Glu Glu His Glu Thr Leu Leu 180 185 190
Leu Arg Arg Lys Phe Phe Tyr Ser Asp Gln Asn Val Asp Ser Arg Asp 195
200 205 Pro Val Gln Leu Asn Leu Leu Tyr Val Gln Ala Arg Asp Asp Ile
Leu 210 215 220 Asn Gly Ser His Pro Val Ser Phe Asp Lys Ala Cys Glu
Phe Ala Gly 225 230 235 240 Phe Gln Cys Gln Ile Gln Phe Gly Pro His
Asn Glu Gln Lys His Lys 245 250 255 Ala Gly Phe Leu Asp Leu Lys Asp
Phe Leu Pro Lys Glu Tyr Val Lys 260 265 270 Gln Lys Gly Glu Arg Lys
Ile Phe Gln Ala His Lys Asn Cys Gly Gln 275 280 285 Met Ser Glu Ile
Glu Ala Lys Val Arg Tyr Val Lys Leu Ala Arg Ser 290 295 300 Leu Lys
Thr Tyr Gly Val Ser Phe Phe Leu Val Lys Glu Lys Met Lys 305 310 315
320 Gly Lys Asn Lys Leu Val Pro Arg Leu Leu Gly Ile Thr Lys Glu Cys
325 330 335 Val Met Arg Val Asp Glu Lys Thr Lys Glu Val Ile Gln Glu
Trp Asn 340 345 350 Leu Thr Asn Ile Lys Arg Trp Ala Ala Ser Pro Lys
Ser Phe Thr Leu 355 360 365 Asp Phe Gly Asp Tyr Gln Asp Gly Tyr Tyr
Ser Val Gln Thr Thr Glu 370 375 380 Gly Glu Gln Ile Ala Gln Leu Ile
Ala Gly Tyr Ile Asp Ile Ile Leu 385 390 395 400 Lys Lys Lys Lys Ser
Lys Asp His Phe Gly Leu Glu Gly Asp Glu Glu 405 410 415 Ser Thr Met
Leu Glu Asp Ser Val Ser Pro Lys Lys Ser Thr Val Leu 420 425 430 Gln
Gln Gln Tyr Asn Arg Val Gly Lys Val Glu His Gly Ser Val Ala 435 440
445 Leu Pro Ala Ile Met Arg Ser Gly Ala Ser Gly Pro Glu Asn Phe Gln
450 455 460 Val Gly Ser Met Pro Pro Ala Gln Gln Gln Ile Thr Ser Gly
Gln Met 465 470 475 480 His Arg Gly His Met Pro Pro Leu Thr Ser Ala
Gln Gln Ala Leu Thr 485 490 495 Gly Thr Ile Asn Ser Ser Met Gln Ala
Val Gln Ala Ala Gln Ala Thr 500 505 510 Leu Asp Asp Phe Asp Thr Leu
Pro Pro Leu Gly Gln Asp Ala Ala Ser 515 520 525 Lys Ala Trp Arg Lys
Asn Lys Met Asp Glu Ser Lys His Glu Ile His 530 535 540 Ser Gln Val
Asp Ala Ile Thr Ala Gly Thr Ala Ser Val Val Asn Leu 545 550 555 560
Thr Ala Gly Asp Pro Ala Glu Thr Asp Tyr Thr Ala Val Gly Cys Ala 565
570 575 Val Thr Thr Ile Ser Ser Asn Leu Thr Glu Met Ser Arg Gly Val
Lys 580 585 590 Leu Leu Ala Ala Leu Leu Glu Asp Glu Gly Gly Ser Gly
Arg Pro Leu 595 600 605 Leu Gln Ala Ala Lys Gly Leu Ala Gly Ala Val
Ser Glu Leu Leu Arg 610 615 620 Ser Ala Gln Pro Ala Ser Ala Glu Pro
Arg Gln Asn Leu Leu Gln Ala 625 630 635 640 Ala Gly Asn Val Gly Gln
Ala Ser Gly Glu Leu Leu Gln Gln Ile Gly 645 650 655 Glu Ser Asp Thr
Asp Pro His Phe Gln Asp Ala Leu Met Gln Leu Ala 660 665 670 Lys Ala
Val Ala Ser Ala Ala Ala Ala Leu Val Leu Lys Ala Lys Ser 675 680 685
Val Ala Gln Arg Thr Glu Asp Ser Gly Leu Gln Thr Gln Val Ile Ala 690
695 700 Ala Ala Thr Gln Cys Ala Leu Ser Thr Ser Gln Leu Val Ala Cys
Thr 705 710 715 720 Lys Val Val Ala Pro Thr Ile Ser Ser Pro Val Cys
Gln Glu Gln Leu 725 730 735 Val Glu Ala Gly Arg Leu Val Ala Lys Ala
Val Glu Gly Cys Val Ser 740 745 750 Ala Ser Gln Ala Ala Thr Glu Asp
Gly Gln Leu Leu Arg Gly Val Gly 755 760 765 Ala Ala Ala Thr Ala Val
Thr Gln Ala Leu Asn Glu Leu Leu Gln His 770 775 780 Val Lys Ala His
Ala Thr Gly Ala Gly Pro Ala Gly Arg Tyr Asp Gln 785 790 795 800 Ala
Thr Asp Thr Ile Leu Thr Val Thr Glu Asn Ile Phe Ser Ser Met 805 810
815 Gly Asp Ala Gly Glu Met Val Gly Gln Ala Arg Ile Leu Ala Gln Ala
820 825 830 Thr Ser Asp Leu Val Asn Ala Ile Lys Ala Asp Ala Glu Gly
Glu Ser 835 840 845 Asp Leu Glu Asn Ser Arg Lys Leu Leu Ser Ala Ala
Lys Ile Leu Ala 850 855 860 Asp Ala Thr Ala Lys Met Val Glu Ala Ala
Lys Gly Ala Ala Ala His 865 870 875 880 Pro Asp Ser Glu Glu Gln Gln
Gln Arg Leu Arg Glu Ala Ala Glu Gly 885 890 895 Leu Arg Met Ala Thr
Asn Ala Ala Ala Gln Asn Ala Ile Lys Lys Lys 900 905 910 Leu Val Gln
Arg Leu Glu His Ala Ala Lys Gln Ala Ala Ala Ser Ala 915 920 925 Thr
Gln Thr Ile Ala Ala Ala Gln His Ala Ala Ser Thr Pro Lys Ala 930 935
940 Ser Ala Gly Pro Gln Pro Leu Leu Val Gln Ser Cys Lys Ala Val Ala
945 950 955 960 Glu Gln Ile Pro Leu Leu Val Gln Gly Val Arg Gly Ser
Gln Ala Gln 965 970 975 Pro
Asp Ser Pro Ser Ala Gln Leu Ala Leu Ile Ala Ala Ser Gln Ser 980 985
990 Phe Leu Gln Pro Gly Gly Lys Met Val Ala Ala Ala Lys Ala Ser Val
995 1000 1005 Pro Thr Ile Gln Asp Gln Ala Ser Ala Met Gln Leu Ser
Gln Cys Ala 1010 1015 1020 42 1024 PRT Artificial Sequence
Description of Artificial Sequence Synthetic Sequence 42 Met Ala
Ala Leu Ser Leu Lys Ile Ser Ile Gly Asp Val Val Lys Thr 1 5 10 15
Met Gln Phe Glu Pro Glu Thr Met Val Tyr Asp Ala Cys Arg Ile Phe 20
25 30 Arg Glu Arg Ile Pro Glu Ala Pro Ala His Pro Pro Ser Asp Phe
Gly 35 40 45 Leu Phe Leu Ile Asp Asp Asp Pro Lys Lys Gly Ile Trp
Lys Glu Ala 50 55 60 Gly Lys Ala Leu Asp Tyr Tyr Leu Leu Arg Asn
Gly Asp Thr Met Glu 65 70 75 80 Tyr Met Lys Lys Gln Arg Pro Leu Lys
Ile Arg Asn Leu Asp Gly Thr 85 90 95 Val Lys Thr Ile Met Gln Asp
Asp Ser Lys Thr Val Thr Asp Met Arg 100 105 110 Met Thr Ile Cys Ala
Arg Ile Gly Ile Ser Asn His Asp Glu Tyr Ser 115 120 125 Leu Val Arg
Thr Leu Met Glu Glu Lys Lys Glu Glu Ile Val Gly Thr 130 135 140 Leu
Arg Lys Asp Lys Thr Leu Trp Arg Asp Glu Lys Lys Met Glu Lys 145 150
155 160 Leu Tyr Gln Lys Leu His Thr Asp Asp Glu Leu Ala Trp Leu Asp
His 165 170 175 Gly Arg Thr Leu Arg Asp Gln Gly Val Glu Glu His Glu
Thr Leu Glu 180 185 190 Leu Arg Arg Lys Phe Phe Tyr Ser Asp Phe Asn
Val Asp Ser Arg Asp 195 200 205 Pro Val Gln Gly Asn Leu Leu Tyr Val
Gln Ala Arg Asp His Ile Leu 210 215 220 Asn Gly Ser His Pro Val Ser
Ile Asp Lys Ala Cys Glu Phe Ala Gly 225 230 235 240 Phe Lys Cys Gln
Ile Gln Phe Gly Pro His Asn Leu Gln Lys His Lys 245 250 255 Ala Gly
Phe Leu Asp Met Lys Asp Phe Leu Pro Lys Glu Tyr Val Asn 260 265 270
Gln Lys Gly Glu Arg Lys Ile Phe Gln Gln His Lys Asn Cys Gly Gln 275
280 285 Met Ser Glu Arg Glu Ala Lys Val Arg Tyr Val Lys Leu Ser Arg
Ser 290 295 300 Leu Lys Thr Tyr Gly Val Ser Thr Phe Leu Val Lys Glu
Lys Met Lys 305 310 315 320 Gly Val Asn Lys Leu Val Pro Arg Leu Leu
Gly Trp Thr Lys Glu Cys 325 330 335 Val Met Arg Val Asp Tyr Lys Thr
Lys Glu Val Ile Gln Glu Trp Ala 340 345 350 Leu Thr Asn Ile Lys Arg
Trp Ala Ala Asp Pro Lys Ser Phe Thr Leu 355 360 365 Asp Phe Gly Glu
Tyr Gln Asp Gly Tyr Tyr Ser Val Gln Phe Thr Glu 370 375 380 Gly Glu
Gln Ile Ala Gln Leu Gly Ala Gly Tyr Ile Asp Ile Ile Leu 385 390 395
400 Lys His Lys Lys Ser Lys Asp His Phe Gly Leu Ile Gly Asp Glu Glu
405 410 415 Ser Thr Met Leu Glu Lys Ser Val Ser Pro Lys Lys Ser Thr
Val Met 420 425 430 Gln Gln Gln Tyr Asn Arg Val Gly Lys Asn Glu His
Gly Ser Val Ala 435 440 445 Leu Pro Ala Gln Met Arg Ser Gly Ala Ser
Gly Pro Glu Arg Phe Gln 450 455 460 Val Gly Ser Met Pro Pro Ala Ser
Gln Gln Ile Thr Ser Gly Gln Met 465 470 475 480 His Thr Gly His Met
Pro Pro Leu Thr Ser Ala Val Gln Ala Leu Thr 485 490 495 Gly Thr Ile
Asn Ser Trp Met Gln Ala Val Gln Ala Ala Gln Ala Tyr 500 505 510 Leu
Asp Asp Phe Asp Thr Leu Pro Pro Ala Gly Gln Asp Ala Ala Ser 515 520
525 Lys Ala Trp Asp Lys Asn Lys Met Asp Glu Ser Lys His Phe Ile His
530 535 540 Ser Gln Val Asp Ala Ile Thr Gly Gly Thr Ala Ser Val Val
Asn Leu 545 550 555 560 Thr His Gly Asp Pro Ala Glu Thr Asp Tyr Thr
Ile Val Gly Cys Ala 565 570 575 Val Thr Thr Ile Ser Lys Asn Leu Thr
Glu Met Ser Arg Gly Val Leu 580 585 590 Leu Leu Ala Ala Leu Leu Glu
Asp Glu Met Gly Ser Gly Arg Pro Leu 595 600 605 Leu Gln Ala Asn Lys
Gly Leu Ala Gly Ala Val Ser Glu Gln Leu Arg 610 615 620 Ser Ala Gln
Pro Ala Ser Ala Arg Pro Arg Gln Asn Leu Leu Gln Ala 625 630 635 640
Ala Ser Asn Val Gly Gln Ala Ser Gly Glu Leu Thr Gln Gln Ile Gly 645
650 655 Glu Ser Asp Thr Asp Val His Phe Gln Asp Ala Leu Met Gln Leu
Trp 660 665 670 Lys Ala Val Ala Ser Ala Ala Ala Ala Tyr Val Leu Lys
Ala Lys Ser 675 680 685 Val Ala Gln Ala Thr Glu Asp Ser Gly Leu Gln
Thr Gln Asp Ile Ala 690 695 700 Ala Ala Thr Gln Cys Ala Leu Glu Thr
Ser Gln Leu Val Ala Cys Thr 705 710 715 720 Lys Phe Val Ala Pro Thr
Ile Ser Ser Pro Val Gly Gln Glu Gln Leu 725 730 735 Val Glu Ala Gly
Arg His Val Ala Lys Ala Val Glu Gly Cys Val Ile 740 745 750 Ala Ser
Gln Ala Ala Thr Glu Asp Gly Lys Leu Leu Arg Gly Val Gly 755 760 765
Ala Ala Ala Leu Ala Val Thr Gln Ala Leu Asn Glu Leu Met Gln His 770
775 780 Val Lys Ala His Ala Thr Gly Asn Gly Pro Ala Gly Arg Tyr Asp
Gln 785 790 795 800 Ala Gln Asp Thr Ile Leu Thr Val Thr Glu Asn Arg
Phe Ser Ser Met 805 810 815 Gly Asp Ala Gly Glu Ser Val Gly Gln Ala
Arg Ile Leu Ala Gln Thr 820 825 830 Thr Ser Asp Leu Val Asn Ala Ile
Lys Val Asp Ala Glu Gly Glu Ser 835 840 845 Asp Leu Glu Trp Ser Arg
Lys Leu Leu Ser Ala Ala Lys Tyr Leu Ala 850 855 860 Asp Ala Thr Ala
Lys Met Val Ala Ala Ala Lys Gly Ala Ala Ala His 865 870 875 880 Pro
Glu Ser Glu Glu Gln Gln Gln Arg Leu Arg Phe Ala Ala Glu Gly 885 890
895 Leu Arg Met Ala Thr Gly Ala Ala Ala Gln Asn Ala Ile Lys Lys His
900 905 910 Leu Val Gln Arg Leu Glu His Ala Ala Ile Gln Ala Ala Ala
Ser Ala 915 920 925 Thr Gln Thr Lys Ala Ala Ala Gln His Ala Ala Ser
Thr Leu Lys Ala 930 935 940 Ser Ala Gly Pro Gln Pro Leu Met Val Gln
Ser Cys Lys Ala Val Ala 945 950 955 960 Glu Asn Ile Pro Leu Leu Val
Gln Gly Val Arg Gln Ser Gln Ala Gln 965 970 975 Pro Asp Ser Pro Ser
Arg Gln Leu Ala Leu Ile Ala Ala Ser Gln Thr 980 985 990 Phe Leu Gln
Pro Gly Gly Lys Met Val Val Ala Ala Lys Ala Ser Val 995 1000 1005
Pro Thr Ile Trp Asp Gln Ala Ser Ala Met Gln Leu Ser Tyr Cys Ala
1010 1015 1020 43 1024 PRT Artificial Sequence Description of
Artificial Sequence Synthetic Sequence 43 Met Val Asp Leu Ser Leu
Lys Ile Ser Ile Gly Asn Glu Val Lys Thr 1 5 10 15 Met Gln Phe Glu
Pro Ser Phe Met Val Tyr Asp Ala Cys Arg Ile Ile 20 25 30 Gly Glu
Arg Ile Pro Glu Ala Pro Ala Gly His Pro Ser Asp Phe Gly 35 40 45
Leu Phe Leu Ser Ile Asp Asp Pro Lys Lys Gly Ile Trp Leu Lys Ala 50
55 60 Gly Lys Ala Leu Asp Tyr Tyr Met Met Arg Asn Gly Asp Thr Met
Glu 65 70 75 80 Tyr Arg Asn Lys Gln Arg Pro Leu Lys Ile Arg Met Gln
Asp Gly Thr 85 90 95 Val Lys Thr Ile Met Val Arg Asp Ser Lys Thr
Val Thr Asp Met Leu 100 105 110 Ser Thr Ile Cys Ala Arg Ile Gly Ile
Thr Thr His Asp Glu Tyr Ser 115 120 125 Leu Val Arg Glu Val Met Glu
Glu Lys Lys Glu Glu Ile Thr Trp Thr 130 135 140 Leu Arg Lys Asp Lys
Thr Leu Leu Tyr Asp Glu Lys Lys Met Glu Lys 145 150 155 160 Leu Lys
Ala Lys Leu His Thr Asp Asp Glu Leu Asn Asp Leu Asp His 165 170 175
Gly Arg Thr Leu Arg Glu Glu Gly Val Glu Glu His Glu Thr Leu Leu 180
185 190 Phe Arg Arg Lys Phe Phe Tyr Ser Asp Gln Gly Val Asp Ser Arg
Asp 195 200 205 Pro Val Gln Leu His Leu Leu Tyr Val Gln Ala Arg Asp
Asp Lys Leu 210 215 220 Asn Gly Ser His Pro Val Ser Phe Leu Lys Ala
Cys Glu Phe Ala Gly 225 230 235 240 Phe Gln Met Gln Ile Gln Phe Gly
Pro His Asn Glu Asn Lys His Lys 245 250 255 Ala Gly Phe Leu Asp Leu
Gln Asp Phe Leu Pro Lys Glu Tyr Val Lys 260 265 270 Arg Lys Gly Glu
Arg Lys Ile Phe Gln Ala Ser Lys Asn Cys Gly Gln 275 280 285 Met Ser
Glu Ile Thr Ala Lys Val Arg Tyr Val Lys Leu Ala Val Ser 290 295 300
Leu Lys Thr Tyr Gly Val Ser Phe Trp Leu Val Lys Glu Lys Met Lys 305
310 315 320 Gly Lys Tyr Lys Leu Val Pro Arg Leu Leu Gly Ile Ala Lys
Glu Cys 325 330 335 Val Met Arg Val Asp Glu Asp Thr Lys Glu Val Ile
Gln Glu Trp Asn 340 345 350 Glu Thr Asn Ile Lys Arg Trp Ala Ala Ser
Phe Lys Ser Phe Thr Leu 355 360 365 Asp Phe Gly Asp Gly Gln Asp Gly
Tyr Tyr Ser Val Gln Thr His Glu 370 375 380 Gly Glu Gln Ile Ala Gln
Leu Ile Ile Gly Tyr Ile Asp Ile Ile Leu 385 390 395 400 Lys Lys Leu
Lys Ser Lys Asp His Phe Gly Leu Glu Met Asp Glu Glu 405 410 415 Ser
Thr Met Leu Glu Asp Asn Val Ser Pro Lys Lys Ser Thr Val Leu 420 425
430 Arg Gln Gln Tyr Asn Arg Val Gly Lys Val Ser His Gly Ser Val Ala
435 440 445 Leu Pro Ala Ile Thr Arg Ser Gly Ala Ser Gly Pro Glu Asn
Val Gln 450 455 460 Val Gly Ser Met Pro Pro Ala Gln Trp Gln Ile Thr
Ser Gly Gln Met 465 470 475 480 His Arg Tyr His Met Pro Pro Leu Thr
Ser Ala Gln Ala Ala Leu Thr 485 490 495 Gly Thr Ile Asn Ser Ser Asp
Gln Ala Val Gln Ala Ala Gln Ala Thr 500 505 510 Glu Asp Asp Phe Asp
Thr Leu Pro Pro Leu Phe Gln Asp Ala Ala Ser 515 520 525 Lys Ala Trp
Arg Gly Asn Lys Met Asp Glu Ser Lys His Glu His His 530 535 540 Ser
Gln Val Asp Ala Ile Thr Ala Ile Thr Ala Ser Val Val Asn Leu 545 550
555 560 Thr Ala Lys Asp Pro Ala Glu Thr Asp Tyr Thr Ala Leu Gly Cys
Ala 565 570 575 Val Thr Thr Ile Ser Ser Met Leu Thr Glu Met Ser Arg
Gly Val Lys 580 585 590 Asn Leu Ala Ala Leu Leu Glu Asp Glu Gly Gln
Ser Gly Arg Pro Leu 595 600 605 Leu Gln Ala Ala Arg Gly Leu Ala Gly
Ala Val Ser Glu Leu Ser Arg 610 615 620 Ser Ala Gln Pro Ala Ser Ala
Glu Thr Arg Gln Asn Leu Leu Gln Ala 625 630 635 640 Ala Gly Val Val
Gly Gln Ala Ser Gly Glu Leu Leu Trp Gln Ile Gly 645 650 655 Glu Ser
Asp Thr Asp Pro Tyr Phe Gln Asp Ala Leu Met Gln Leu Ala 660 665 670
Asp Ala Val Ala Ser Ala Ala Ala Ala Leu Glu Leu Lys Ala Lys Ser 675
680 685 Val Ala Gln Arg Phe Glu Asp Ser Gly Leu Gln Thr Gln Val Gly
Ala 690 695 700 Ala Ala Thr Gln Cys Ala Leu Ser His Ser Gln Leu Val
Ala Cys Thr 705 710 715 720 Lys Val Ile Ala Pro Thr Ile Ser Ser Pro
Val Cys Lys Glu Gln Leu 725 730 735 Val Glu Ala Gly Arg Leu Leu Ala
Lys Ala Val Glu Gly Cys Val Ser 740 745 750 Met Ser Gln Ala Ala Thr
Glu Asp Gly Gln Asn Leu Arg Gly Val Gly 755 760 765 Ala Ala Ala Thr
Gln Val Thr Gln Ala Leu Asn Glu Leu Leu Arg His 770 775 780 Val Lys
Ala His Ala Thr Gly Ala Ser Pro Ala Gly Arg Tyr Asp Gln 785 790 795
800 Ala Thr Thr Thr Ile Leu Thr Val Thr Glu Asn Ile Val Ser Ser Met
805 810 815 Gly Asp Ala Gly Glu Met Trp Gly Gln Ala Arg Ile Leu Ala
Gln Ala 820 825 830 Tyr Ser Asp Leu Val Asn Ala Ile Lys Ala Ala Ala
Glu Gly Glu Ser 835 840 845 Asp Leu Glu Asn Asp Arg Lys Leu Leu Ser
Ala Ala Lys Ile Glu Ala 850 855 860 Asp Ala Thr Ala Lys Met Val Glu
Phe Ala Lys Gly Ala Ala Ala His 865 870 875 880 Pro Asp Gly Glu Glu
Gln Gln Gln Arg Leu Arg Glu His Ala Glu Gly 885 890 895 Leu Arg Met
Ala Thr Asn Ile Ala Ala Gln Asn Ala Ile Lys Lys Lys 900 905 910 Lys
Val Gln Arg Leu Glu His Ala Ala Lys Leu Ala Ala Ala Ser Ala 915 920
925 Thr Gln Thr Ile Met Ala Ala Gln His Ala Ala Ser Thr Pro Asn Ala
930 935 940 Ser Ala Gly Pro Gln Pro Leu Leu Gln Gln Ser Cys Lys Ala
Val Ala 945 950 955 960 Glu Gln Arg Pro Leu Leu Val Gln Gly Val Arg
Gly Thr Gln Ala Gln 965 970 975 Pro Asp Ser Pro Ser Ala Val Leu Ala
Leu Ile Ala Ala Ser Gln Ser 980 985 990 Trp Leu Gln Pro Gly Gly Lys
Met Val Ala Tyr Ala Lys Ala Ser Val 995 1000 1005 Pro Thr Ile Gln
Ala Gln Ala Ser Ala Met Gln Leu Ser Gln Asp Ala 1010 1015 1020 44
1024 PRT Artificial Sequence Description of Artificial Sequence
Synthetic Sequence 44 Met Val Ala Ala Ser Leu Lys Ile Ser Ile Gly
Asn Val Asp Lys Thr 1 5 10 15 Met Gln Phe Glu Pro Ser Thr Glu Val
Tyr Asp Ala Cys Arg Ile Ile 20 25 30 Arg Phe Arg Ile Pro Glu Ala
Pro Ala Gly Pro Gly Ser Asp Phe Gly 35 40 45 Leu Phe Leu Ser Asp
His Asp Pro Lys Lys Gly Ile Trp Leu Glu Ile 50 55 60 Gly Lys Ala
Leu Asp Tyr Tyr Met Leu Lys Asn Gly Asp Thr Met Glu 65 70 75 80 Tyr
Arg Lys Leu Gln Arg Pro Leu Lys Ile Arg Met Leu Met Gly Thr 85 90
95 Val Lys Thr Ile Met Val Asp Asn Ser Lys Thr Val Thr Asp Met Leu
100 105 110 Met Gln Ile Cys Ala Arg Ile Gly Ile Thr Asn Arg Asp Glu
Tyr Ser 115 120 125 Leu Val Arg Glu Leu Ser Glu Glu Lys Lys Glu Glu
Ile Thr Gly Val 130 135 140 Leu Arg Lys Asp Lys Thr Leu Leu Arg Trp
Glu Lys Lys Met Glu Lys 145 150 155 160 Leu Lys Gln Tyr Leu His Thr
Asp Asp Glu Leu Asn Trp Ala Asp His 165 170 175 Gly Arg Thr Leu Arg
Glu Gln Asp Val Glu Glu His Glu Thr Leu Leu 180 185 190 Leu Glu Arg
Lys Phe Phe Tyr Ser Asp Gln Asn Phe Asp Ser Arg Asp 195 200 205 Pro
Val Gln Leu Asn Gly Leu Tyr Val Gln Ala Arg Asp Asp Ile His 210 215
220 Asn Gly Ser His Pro Val Ser Phe Asp Ile Ala Cys Glu Phe Ala Gly
225 230 235 240 Phe Gln Cys Lys Ile Gln Phe Gly Pro His Asn Glu Gln
Leu His Lys 245 250 255 Ala Gly Phe Leu Asp Leu Lys Met Phe Leu Pro
Lys Glu Tyr Val Lys 260 265 270 Gln Asn Gly Glu Arg Lys Ile Phe Gln
Ala His Gln Asn Cys Gly Gln 275 280 285 Met Ser Glu Ile Glu Arg Lys
Val Arg Tyr Val Lys Leu Ala Arg Thr 290 295 300 Leu Lys Thr Tyr Gly
Val Ser Phe Phe Val Val Lys Glu Lys Met Lys 305 310 315 320 Gly
Lys
Asn Trp Leu Val Pro Arg Leu Leu Gly Ile Thr Tyr Glu Cys 325 330 335
Val Met Arg Val Asp Glu Lys Ala Lys Glu Val Ile Gln Glu Trp Asn 340
345 350 Leu Asp Asn Ile Lys Arg Trp Ala Ala Ser Pro Glu Ser Phe Thr
Leu 355 360 365 Asp Phe Gly Asp Tyr Phe Asp Gly Tyr Tyr Ser Val Gln
Thr Thr Gly 370 375 380 Gly Glu Gln Ile Ala Gln Leu Ile Ala His Tyr
Ile Asp Ile Ile Leu 385 390 395 400 Lys Lys Lys Ile Ser Lys Asp His
Phe Gly Leu Glu Gly Lys Glu Glu 405 410 415 Ser Thr Met Leu Glu Asp
Ser Leu Ser Pro Lys Lys Ser Thr Val Leu 420 425 430 Gln Met Gln Tyr
Asn Arg Val Gly Lys Val Glu Asn Gly Ser Val Ala 435 440 445 Leu Pro
Ala Ile Met Gln Ser Gly Ala Ser Gly Pro Glu Asn Phe Arg 450 455 460
Val Gly Ser Met Pro Pro Ala Gln Gln Ser Ile Thr Ser Gly Gln Met 465
470 475 480 His Arg Gly Thr Met Pro Pro Leu Thr Ser Ala Gln Gln Val
Leu Thr 485 490 495 Gly Thr Ile Asn Ser Ser Met Trp Ala Val Gln Ala
Ala Gln Ala Thr 500 505 510 Leu Tyr Asp Phe Asp Thr Leu Pro Pro Leu
Gly Ala Asp Ala Ala Ser 515 520 525 Lys Ala Trp Arg Lys Asp Lys Met
Asp Glu Ser Lys His Glu Ile Glu 530 535 540 Ser Gln Val Asp Ala Ile
Thr Ala Gly Phe Ala Ser Val Val Asn Leu 545 550 555 560 Thr Ala Gly
Gly Pro Ala Glu Thr Asp Tyr Thr Ala Val His Cys Ala 565 570 575 Val
Thr Thr Ile Ser Ser Asn Ile Thr Glu Met Ser Arg Gly Val Lys 580 585
590 Leu Lys Ala Ala Leu Leu Glu Asp Glu Gly Gly Leu Gly Arg Pro Leu
595 600 605 Leu Gln Ala Ala Lys Met Leu Ala Gly Ala Val Ser Glu Leu
Leu Asn 610 615 620 Ser Ala Gln Pro Ala Ser Ala Glu Pro Gln Gln Asn
Leu Leu Gln Ala 625 630 635 640 Ala Gly Asn Arg Gly Gln Ala Ser Gly
Glu Leu Leu Gln Ser Ile Gly 645 650 655 Glu Ser Asp Thr Asp Pro His
Thr Gln Asp Ala Leu Met Gln Leu Ala 660 665 670 Lys Val Val Ala Ser
Ala Ala Ala Ala Leu Val Trp Lys Ala Lys Ser 675 680 685 Val Ala Gln
Arg Thr Tyr Asp Ser Gly Leu Gln Thr Gln Val Ile Asp 690 695 700 Ala
Ala Thr Gln Cys Ala Leu Ser Thr Glu Gln Leu Val Ala Cys Thr 705 710
715 720 Lys Val Val Phe Pro Thr Ile Ser Ser Pro Val Cys Gln Gly Gln
Leu 725 730 735 Val Glu Ala Gly Arg Leu Val His Lys Ala Val Glu Gly
Cys Val Ser 740 745 750 Ala Ile Gln Ala Ala Thr Glu Asp Gly Gln Leu
Lys Arg Gly Val Gly 755 760 765 Ala Ala Ala Thr Ala Leu Thr Gln Ala
Leu Asn Glu Leu Leu Gln Met 770 775 780 Val Lys Ala His Ala Thr Gly
Ala Gly Asn Ala Gly Arg Tyr Asp Gln 785 790 795 800 Ala Thr Asp Gln
Ile Leu Thr Val Thr Glu Asn Ile Phe Arg Ser Met 805 810 815 Gly Asp
Ala Gly Glu Met Val Ser Gln Ala Arg Ile Leu Ala Gln Ala 820 825 830
Thr Thr Asp Leu Val Asn Ala Ile Lys Ala Asp Val Glu Gly Glu Ser 835
840 845 Asp Leu Glu Asn Ser Trp Lys Leu Leu Ser Ala Ala Lys Ile Leu
Tyr 850 855 860 Asp Ala Thr Ala Lys Met Val Glu Ala Asp Lys Gly Ala
Ala Ala His 865 870 875 880 Pro Asp Ser Phe Glu Gln Gln Gln Arg Leu
Arg Glu Ala Gly Glu Gly 885 890 895 Leu Arg Met Ala Thr Asn Ala His
Ala Gln Asn Ala Ile Lys Lys Lys 900 905 910 Leu Ile Gln Arg Leu Glu
His Ala Ala Lys Gln Lys Ala Ala Ser Ala 915 920 925 Thr Gln Thr Ile
Ala Met Ala Gln His Ala Ala Ser Thr Pro Lys Asn 930 935 940 Ser Ala
Gly Pro Gln Pro Leu Leu Val Arg Ser Cys Lys Ala Val Ala 945 950 955
960 Glu Gln Ile Ser Leu Leu Val Gln Gly Val Arg Gly Ser Thr Ala Gln
965 970 975 Pro Asp Ser Pro Ser Ala Gln Val Ala Leu Ile Ala Ala Ser
Gln Ser 980 985 990 Phe Trp Gln Pro Gly Gly Lys Met Val Ala Ala Tyr
Lys Ala Ser Val 995 1000 1005 Pro Thr Ile Gln Asp Ala Ala Ser Ala
Met Gln Leu Ser Gln Cys Asp 1010 1015 1020 45 1024 PRT Artificial
Sequence Description of Artificial Sequence Synthetic Sequence 45
Met Val Ala Leu Ala Leu Lys Ile Ser Ile Gly Asn Val Val Asp Thr 1 5
10 15 Met Gln Phe Glu Pro Ser Thr Met Glu Tyr Asp Ala Cys Arg Ile
Ile 20 25 30 Arg Glu Phe Ile Pro Glu Ala Pro Ala Gly Pro Pro Gly
Asp Phe Gly 35 40 45 Leu Phe Leu Ser Asp Asp His Pro Lys Lys Gly
Ile Trp Leu Glu Ala 50 55 60 Ile Lys Ala Leu Asp Tyr Tyr Met Leu
Arg Lys Gly Asp Thr Met Glu 65 70 75 80 Tyr Arg Lys Lys Leu Arg Pro
Leu Lys Ile Arg Met Leu Asp Met Thr 85 90 95 Val Lys Thr Ile Met
Val Asp Asp Asn Lys Thr Val Thr Asp Met Leu 100 105 110 Met Thr Gln
Cys Ala Arg Ile Gly Ile Thr Asn His Arg Glu Tyr Ser 115 120 125 Leu
Val Arg Glu Leu Met Ser Glu Lys Lys Glu Glu Ile Thr Gly Thr 130 135
140 Thr Arg Lys Asp Lys Thr Leu Leu Arg Asp Val Lys Lys Met Glu Lys
145 150 155 160 Leu Lys Gln Lys Trp His Thr Asp Asp Glu Leu Asn Trp
Leu Tyr His 165 170 175 Gly Arg Thr Leu Arg Glu Gln Gly Ala Glu Glu
His Glu Thr Leu Leu 180 185 190 Leu Arg Asp Lys Phe Phe Tyr Ser Asp
Gln Asn Val Glu Ser Arg Asp 195 200 205 Pro Val Gln Leu Asn Leu Phe
Tyr Val Gln Ala Arg Asp Asp Ile Leu 210 215 220 Gly Gly Ser His Pro
Val Ser Phe Asp Lys His Cys Glu Phe Ala Gly 225 230 235 240 Phe Gln
Cys Gln Lys Gln Phe Gly Pro His Asn Glu Gln Lys Leu Lys 245 250 255
Ala Gly Phe Leu Asp Leu Lys Asp Met Leu Pro Lys Glu Tyr Val Lys 260
265 270 Gln Lys Asn Glu Arg Lys Ile Phe Gln Ala His Lys Gln Cys Gly
Gln 275 280 285 Met Ser Glu Ile Glu Ala Arg Val Arg Tyr Val Lys Leu
Ala Arg Ser 290 295 300 Ser Lys Thr Tyr Gly Val Ser Phe Phe Leu Thr
Lys Glu Lys Met Lys 305 310 315 320 Gly Lys Asn Lys Val Val Pro Arg
Leu Leu Gly Ile Thr Lys Trp Cys 325 330 335 Val Met Arg Val Asp Glu
Lys Thr Tyr Glu Val Ile Gln Glu Trp Asn 340 345 350 Leu Thr Ala Ile
Lys Arg Trp Ala Ala Ser Pro Lys Asp Phe Thr Leu 355 360 365 Asp Phe
Gly Asp Tyr Gln Glu Gly Tyr Tyr Ser Val Gln Thr Thr Glu 370 375 380
Phe Glu Gln Ile Ala Gln Leu Ile Ala Gly Gly Ile Asp Ile Ile Leu 385
390 395 400 Lys Lys Lys Lys His Lys Asp His Phe Gly Leu Glu Gly Asp
Ile Glu 405 410 415 Ser Thr Met Leu Glu Asp Ser Val Lys Pro Lys Lys
Ser Thr Val Leu 420 425 430 Gln Gln Leu Tyr Asn Arg Val Gly Lys Val
Glu His Met Ser Val Ala 435 440 445 Leu Pro Ala Ile Met Arg Asn Gly
Ala Ser Gly Pro Glu Asn Phe Gln 450 455 460 Gln Gly Ser Met Pro Pro
Ala Gln Gln Gln Arg Thr Ser Gly Gln Met 465 470 475 480 His Arg Gly
His Ser Pro Pro Leu Thr Ser Ala Gln Gln Ala Thr Thr 485 490 495 Gly
Thr Ile Asn Ser Ser Met Gln Val Val Gln Ala Ala Gln Ala Thr 500 505
510 Leu Asp Trp Phe Asp Thr Leu Pro Pro Leu Gly Gln Tyr Ala Ala Ser
515 520 525 Lys Ala Trp Arg Lys Asn Ala Met Asp Glu Ser Lys His Glu
Ile His 530 535 540 Asp Gln Val Asp Ala Ile Thr Ala Gly Thr Glu Ser
Val Val Asn Leu 545 550 555 560 Thr Ala Gly Asp Phe Ala Glu Thr Asp
Tyr Thr Ala Val Gly Gly Ala 565 570 575 Val Thr Thr Ile Ser Ser Asn
Leu His Glu Met Ser Arg Gly Val Lys 580 585 590 Leu Leu Ile Ala Leu
Leu Glu Asp Glu Gly Gly Ser Lys Arg Pro Leu 595 600 605 Leu Gln Ala
Ala Lys Gly Met Ala Gly Ala Val Ser Glu Leu Leu Arg 610 615 620 Asn
Ala Gln Pro Ala Ser Ala Glu Pro Arg Arg Asn Leu Leu Gln Ala 625 630
635 640 Ala Gly Asn Val Ser Gln Ala Ser Gly Glu Leu Leu Gln Gln Thr
Gly 645 650 655 Glu Ser Asp Thr Asp Pro His Phe Val Asp Ala Leu Met
Gln Leu Ala 660 665 670 Lys Ala Trp Ala Ser Ala Ala Ala Ala Leu Val
Leu Tyr Ala Lys Ser 675 680 685 Val Ala Gln Arg Thr Glu Ala Ser Gly
Leu Gln Thr Gln Val Ile Ala 690 695 700 Asp Ala Thr Gln Cys Ala Leu
Ser Thr Ser Glu Leu Val Ala Cys Thr 705 710 715 720 Lys Val Val Ala
Phe Thr Ile Ser Ser Pro Val Cys Gln Glu Gly Leu 725 730 735 Val Glu
Ala Gly Arg Leu Val Ala His Ala Val Glu Gly Cys Val Ser 740 745 750
Ala Ser Ile Ala Ala Thr Glu Asp Gly Gln Leu Leu Lys Gly Val Gly 755
760 765 Ala Ala Ala Thr Ala Val Leu Gln Ala Leu Asn Glu Leu Leu Gln
His 770 775 780 Met Lys Ala His Ala Thr Gly Ala Gly Pro Asn Gly Arg
Tyr Asp Gln 785 790 795 800 Ala Thr Asp Thr Gln Leu Thr Val Thr Glu
Asn Ile Phe Ser Arg Met 805 810 815 Gly Asp Ala Gly Glu Met Val Gly
Ser Ala Arg Ile Leu Ala Gln Ala 820 825 830 Thr Ser Thr Leu Val Asn
Ala Ile Lys Ala Asp Ala Val Gly Glu Ser 835 840 845 Asp Leu Glu Asn
Ser Arg Trp Leu Leu Ser Ala Ala Lys Ile Leu Ala 850 855 860 Tyr Ala
Thr Ala Lys Met Val Glu Ala Ala Ala Gly Ala Ala Ala His 865 870 875
880 Pro Asp Ser Glu Asp Gln Gln Gln Arg Leu Arg Glu Ala Ala Phe Gly
885 890 895 Leu Arg Met Ala Thr Asn Ala Ala Gly Gln Asn Ala Ile Lys
Lys Lys 900 905 910 Leu Val His Arg Leu Glu His Ala Ala Lys Gln Ala
Ile Ala Ser Ala 915 920 925 Thr Gln Thr Ile Ala Ala Lys Gln His Ala
Ala Ser Thr Pro Lys Ala 930 935 940 Leu Ala Gly Pro Gln Pro Leu Leu
Val Gln Met Cys Lys Ala Val Ala 945 950 955 960 Glu Gln Ile Pro Asn
Leu Val Gln Gly Val Arg Gly Ser Gln Gln Gln 965 970 975 Pro Asp Ser
Pro Ser Ala Gln Leu Arg Leu Ile Ala Ala Ser Gln Ser 980 985 990 Phe
Leu Ser Pro Gly Gly Lys Met Val Ala Ala Ala Thr Ala Ser Val 995
1000 1005 Pro Thr Ile Gln Asp Gln Val Ser Ala Met Gln Leu Ser Gln
Cys Ala 1010 1015 1020 46 1024 PRT Artificial Sequence Description
of Artificial Sequence Synthetic Sequence 46 Met Val Ala Leu Ser
Ala Lys Ile Ser Ile Gly Asn Val Val Lys Asp 1 5 10 15 Met Gln Phe
Glu Pro Ser Thr Met Val Glu Asp Ala Cys Arg Ile Ile 20 25 30 Arg
Glu Arg Phe Pro Glu Ala Pro Ala Gly Pro Pro Ser Gly Phe Gly 35 40
45 Leu Phe Leu Ser Asp Asp Asp His Lys Lys Gly Ile Trp Leu Glu Ala
50 55 60 Gly Ile Ala Leu Asp Tyr Tyr Met Leu Arg Asn Lys Asp Thr
Met Glu 65 70 75 80 Tyr Arg Lys Lys Gln Leu Pro Leu Lys Ile Arg Met
Leu Asp Gly Met 85 90 95 Val Lys Thr Ile Met Val Asp Asp Ser Asn
Thr Val Thr Asp Met Leu 100 105 110 Met Thr Ile Gln Ala Arg Ile Gly
Ile Thr Asn His Asp Arg Tyr Ser 115 120 125 Leu Val Arg Glu Leu Met
Glu Ser Lys Lys Glu Glu Ile Thr Gly Thr 130 135 140 Leu Thr Lys Asp
Lys Thr Leu Leu Arg Asp Glu Val Lys Met Glu Lys 145 150 155 160 Leu
Lys Gln Lys Leu Trp Thr Asp Asp Glu Leu Asn Trp Leu Asp Tyr 165 170
175 Gly Arg Thr Leu Arg Glu Gln Gly Val Ala Glu His Glu Thr Leu Leu
180 185 190 Leu Arg Arg Asp Phe Phe Tyr Ser Asp Gln Asn Val Asp Glu
Arg Asp 195 200 205 Pro Val Gln Leu Asn Leu Leu Phe Val Gln Ala Arg
Asp Asp Ile Leu 210 215 220 Asn His Ser His Pro Val Ser Phe Asp Lys
Ala Ile Glu Phe Ala Gly 225 230 235 240 Phe Gln Cys Gln Ile Lys Phe
Gly Pro His Asn Glu Gln Lys His Leu 245 250 255 Ala Gly Phe Leu Asp
Leu Lys Asp Phe Met Pro Lys Glu Tyr Val Lys 260 265 270 Gln Lys Gly
Asn Arg Lys Ile Phe Gln Ala His Lys Asn Gln Gly Gln 275 280 285 Met
Ser Glu Ile Glu Ala Lys Arg Arg Tyr Val Lys Leu Ala Arg Ser 290 295
300 Leu Ser Thr Tyr Gly Val Ser Phe Phe Leu Val Thr Glu Lys Met Lys
305 310 315 320 Gly Lys Asn Lys Leu Trp Pro Arg Leu Leu Gly Ile Thr
Lys Glu Tyr 325 330 335 Val Met Arg Val Asp Glu Lys Thr Lys Ala Val
Ile Gln Glu Trp Asn 340 345 350 Leu Thr Asn Asp Lys Arg Trp Ala Ala
Ser Pro Lys Ser Glu Thr Leu 355 360 365 Asp Phe Gly Asp Tyr Gln Asp
Phe Tyr Tyr Ser Val Gln Thr Thr Glu 370 375 380 Gly Gly Gln Ile Ala
Gln Leu Ile Ala Gly Tyr His Asp Ile Ile Leu 385 390 395 400 Lys Lys
Lys Lys Ser Ile Asp His Phe Gly Leu Glu Gly Asp Glu Lys 405 410 415
Ser Thr Met Leu Glu Asp Ser Val Ser Leu Lys Lys Ser Thr Val Leu 420
425 430 Gln Gln Gln Met Asn Arg Val Gly Lys Val Glu His Gly Asn Val
Ala 435 440 445 Leu Pro Ala Ile Met Arg Ser Gln Ala Ser Gly Pro Glu
Asn Phe Gln 450 455 460 Val Arg Ser Met Pro Pro Ala Gln Gln Gln Ile
Ser Ser Gly Gln Met 465 470 475 480 His Arg Gly His Met Thr Pro Leu
Thr Ser Ala Gln Gln Ala Leu Val 485 490 495 Gly Thr Ile Asn Ser Ser
Met Gln Ala Trp Gln Ala Ala Gln Ala Thr 500 505 510 Leu Asp Asp Tyr
Asp Thr Leu Pro Pro Leu Gly Gln Asp Asp Ala Ser 515 520 525 Lys Ala
Trp Arg Lys Asn Lys Glu Asp Glu Ser Lys His Glu Ile His 530 535 540
Ser Phe Val Asp Ala Ile Thr Ala Gly Thr Ala Gly Val Val Asn Leu 545
550 555 560 Thr Ala Gly Asp Pro His Glu Thr Asp Tyr Thr Ala Val Gly
Cys Ile 565 570 575 Val Thr Thr Ile Ser Ser Asn Leu Thr Lys Met Ser
Arg Gly Val Lys 580 585 590 Leu Leu Ala Leu Leu Leu Glu Asp Glu Gly
Gly Ser Gly Met Pro Leu 595 600 605 Leu Gln Ala Ala Lys Gly Leu Asn
Gly Ala Val Ser Glu Leu Leu Arg 610 615 620 Ser Gln Gln Pro Ala Ser
Ala Glu Pro Arg Gln Arg Leu Leu Gln Ala 625 630 635 640 Ala Gly Asn
Val Gly Ser Ala Ser Gly Glu Leu Leu Gln Gln Ile Thr 645 650 655 Glu
Ser Asp Thr Asp Pro His Phe Gln Val Ala Leu Met Gln Leu Ala 660 665
670 Lys Ala Val Trp Ser Ala Ala Ala Ala Leu Val Leu Lys Tyr Lys Ser
675 680 685 Val Ala Gln Arg Thr Glu Asp Ala Gly Leu Gln Thr Gln Val
Ile Ala 690 695
700 Ala Asp Thr Gln Cys Ala Leu Ser Thr Ser Gln Glu Val Ala Cys Thr
705 710 715 720 Lys Val Val Ala Pro Phe Ile Ser Ser Pro Val Cys Gln
Glu Gln Gly 725 730 735 Val Glu Ala Gly Arg Leu Val Ala Lys His Val
Glu Gly Cys Val Ser 740 745 750 Ala Ser Gln Ile Ala Thr Glu Asp Gly
Gln Leu Leu Arg Lys Val Gly 755 760 765 Ala Ala Ala Thr Ala Val Thr
Leu Ala Leu Asn Glu Leu Leu Gln His 770 775 780 Val Met Ala His Ala
Thr Gly Ala Gly Pro Ala Asn Arg Tyr Asp Gln 785 790 795 800 Ala Thr
Asp Thr Ile Gln Thr Val Thr Glu Asn Ile Phe Ser Ser Arg 805 810 815
Gly Asp Ala Gly Glu Met Val Gly Gln Ser Arg Ile Leu Ala Gln Ala 820
825 830 Thr Ser Asp Thr Val Asn Ala Ile Lys Ala Asp Ala Glu Val Glu
Ser 835 840 845 Asp Leu Glu Asn Ser Arg Lys Trp Leu Ser Ala Ala Lys
Ile Leu Ala 850 855 860 Asp Tyr Thr Ala Lys Met Val Glu Ala Ala Lys
Ala Ala Ala Ala His 865 870 875 880 Pro Asp Ser Glu Glu Asp Gln Gln
Arg Leu Arg Glu Ala Ala Glu Glu 885 890 895 Leu Arg Met Ala Thr Asn
Ala Ala Ala Phe Asn Ala Ile Lys Lys Lys 900 905 910 Leu Val Gln Gly
Leu Glu His Ala Ala Lys Gln Ala Ala His Ser Ala 915 920 925 Thr Gln
Thr Ile Ala Ala Ala Ile His Ala Ala Ser Thr Pro Lys Ala 930 935 940
Ser Lys Gly Pro Gln Pro Leu Leu Val Gln Ser Leu Lys Ala Val Ala 945
950 955 960 Glu Gln Ile Pro Leu Met Val Gln Gly Val Arg Gly Ser Gln
Ala Asn 965 970 975 Pro Asp Ser Pro Ser Ala Gln Leu Ala Gln Ile Ala
Ala Ser Gln Ser 980 985 990 Phe Leu Gln Arg Gly Gly Lys Met Val Ala
Ala Ala Lys Ser Ser Val 995 1000 1005 Pro Thr Ile Gln Asp Gln Ala
Thr Ala Met Gln Leu Ser Gln Cys Ala 1010 1015 1020 47 1024 PRT
Artificial Sequence Description of Artificial Sequence Synthetic
Sequence 47 Met Val Ala Leu Ser Leu Ala Ile Ser Ile Gly Asn Val Val
Lys Thr 1 5 10 15 Asp Gln Phe Glu Pro Ser Thr Met Val Tyr Glu Ala
Cys Arg Ile Ile 20 25 30 Arg Glu Arg Ile Phe Glu Ala Pro Ala Gly
Pro Pro Ser Asp Gly Gly 35 40 45 Leu Phe Leu Ser Asp Asp Asp Pro
His Lys Gly Ile Trp Leu Glu Ala 50 55 60 Gly Lys Ile Leu Asp Tyr
Tyr Met Leu Arg Asn Gly Lys Thr Met Glu 65 70 75 80 Tyr Arg Lys Lys
Gln Arg Leu Leu Lys Ile Arg Met Leu Asp Gly Thr 85 90 95 Met Lys
Thr Ile Met Val Asp Asp Ser Lys Asn Val Thr Asp Met Leu 100 105 110
Met Thr Ile Cys Gln Arg Ile Gly Ile Thr Asn His Asp Glu Arg Ser 115
120 125 Leu Val Arg Glu Leu Met Glu Glu Ser Lys Glu Glu Ile Thr Gly
Thr 130 135 140 Leu Arg Thr Asp Lys Thr Leu Leu Arg Asp Glu Lys Val
Met Glu Lys 145 150 155 160 Leu Lys Gln Lys Leu His Trp Asp Asp Glu
Leu Asn Trp Leu Asp His 165 170 175 Tyr Arg Thr Leu Arg Glu Gln Gly
Val Glu Ala His Glu Thr Leu Leu 180 185 190 Leu Arg Arg Lys Asp Phe
Tyr Ser Asp Gln Asn Val Asp Ser Glu Asp 195 200 205 Pro Val Gln Leu
Asn Leu Leu Tyr Phe Gln Ala Arg Asp Asp Ile Leu 210 215 220 Asn Gly
Gly His Pro Val Ser Phe Asp Lys Ala Cys His Phe Ala Gly 225 230 235
240 Phe Gln Cys Gln Ile Gln Ile Gly Pro His Asn Glu Gln Lys His Lys
245 250 255 Lys Gly Phe Leu Asp Leu Lys Asp Phe Leu Leu Lys Glu Tyr
Val Lys 260 265 270 Gln Lys Gly Glu Met Lys Ile Phe Gln Ala His Lys
Asn Cys Asn Gln 275 280 285 Met Ser Glu Ile Glu Ala Lys Val Gln Tyr
Val Lys Leu Ala Arg Ser 290 295 300 Leu Lys Arg Tyr Gly Val Ser Phe
Phe Leu Val Lys Ser Lys Met Lys 305 310 315 320 Gly Lys Asn Lys Leu
Val Thr Arg Leu Leu Gly Ile Thr Lys Glu Cys 325 330 335 Trp Met Arg
Val Asp Glu Lys Thr Lys Glu Tyr Ile Gln Glu Trp Asn 340 345 350 Leu
Thr Asn Ile Ala Arg Trp Ala Ala Ser Pro Lys Ser Phe Asp Leu 355 360
365 Asp Phe Gly Asp Tyr Gln Asp Gly Glu Tyr Ser Val Gln Thr Thr Glu
370 375 380 Gly Glu Phe Ile Ala Gln Leu Ile Ala Gly Tyr Ile Gly Ile
Ile Leu 385 390 395 400 Lys Lys Lys Lys Ser Lys His His Phe Gly Leu
Glu Gly Asp Glu Glu 405 410 415 Ile Thr Met Leu Glu Asp Ser Val Ser
Pro Lys Lys Ser Thr Val Leu 420 425 430 Gln Gln Gln Tyr Leu Arg Val
Gly Lys Val Glu His Gly Ser Met Ala 435 440 445 Leu Pro Ala Ile Met
Arg Ser Gly Asn Ser Gly Pro Glu Asn Phe Gln 450 455 460 Val Gly Gln
Met Pro Pro Ala Gln Gln Gln Ile Thr Arg Gly Gln Met 465 470 475 480
His Arg Gly His Met Pro Ser Leu Thr Ser Ala Gln Gln Ala Leu Thr 485
490 495 Thr Thr Ile Asn Ser Ser Met Gln Ala Val Val Ala Ala Gln Ala
Thr 500 505 510 Leu Asp Asp Phe Trp Thr Leu Pro Pro Leu Gly Gln Asp
Ala Tyr Ser 515 520 525 Lys Ala Trp Arg Lys Asn Lys Met Ala Glu Ser
Lys His Glu Ile His 530 535 540 Ser Gln Asp Asp Ala Ile Thr Ala Gly
Thr Ala Ser Glu Val Asn Leu 545 550 555 560 Thr Ala Gly Asp Pro Ala
Phe Thr Asp Tyr Thr Ala Val Gly Cys Ala 565 570 575 Gly Thr Thr Ile
Ser Ser Asn Leu Thr Glu His Ser Arg Gly Val Lys 580 585 590 Leu Leu
Ala Ala Ile Leu Glu Asp Glu Gly Gly Ser Gly Arg Lys Leu 595 600 605
Leu Gln Ala Ala Lys Gly Leu Ala Leu Ala Val Ser Glu Leu Leu Arg 610
615 620 Ser Ala Met Pro Ala Ser Ala Glu Pro Arg Gln Asn Asn Leu Gln
Ala 625 630 635 640 Ala Gly Asn Val Gly Gln Gln Ser Gly Glu Leu Leu
Gln Gln Ile Gly 645 650 655 Arg Ser Asp Thr Asp Pro His Phe Gln Asp
Ser Leu Met Gln Leu Ala 660 665 670 Lys Ala Val Ala Thr Ala Ala Ala
Ala Leu Val Leu Lys Ala Val Ser 675 680 685 Val Ala Gln Arg Thr Glu
Asp Ser Trp Leu Gln Thr Gln Val Ile Ala 690 695 700 Ala Ala Tyr Gln
Cys Ala Leu Ser Thr Ser Gln Leu Ala Ala Cys Thr 705 710 715 720 Lys
Val Val Ala Pro Thr Asp Ser Ser Pro Val Cys Gln Glu Gln Leu 725 730
735 Glu Glu Ala Gly Arg Leu Val Ala Lys Ala Phe Glu Gly Cys Val Ser
740 745 750 Ala Ser Gln Ala Gly Thr Glu Asp Gly Gln Leu Leu Arg Gly
His Gly 755 760 765 Ala Ala Ala Thr Ala Val Thr Gln Ile Leu Asn Glu
Leu Leu Gln His 770 775 780 Val Lys Lys His Ala Thr Gly Ala Gly Pro
Ala Gly Leu Tyr Asp Gln 785 790 795 800 Ala Thr Asp Thr Ile Leu Met
Val Thr Glu Asn Ile Phe Ser Ser Met 805 810 815 Asn Asp Ala Gly Glu
Met Val Gly Gln Ala Gln Ile Leu Ala Gln Ala 820 825 830 Thr Ser Asp
Leu Arg Asn Ala Ile Lys Ala Asp Ala Glu Gly Ser Ser 835 840 845 Asp
Leu Glu Asn Ser Arg Lys Leu Thr Ser Ala Ala Lys Ile Leu Ala 850 855
860 Asp Ala Val Ala Lys Met Val Glu Ala Ala Lys Gly Trp Ala Ala His
865 870 875 880 Pro Asp Ser Glu Glu Gln Tyr Gln Arg Leu Arg Glu Ala
Ala Glu Gly 885 890 895 Ala Arg Met Ala Thr Asn Ala Ala Ala Gln Asp
Ala Ile Lys Lys Lys 900 905 910 Leu Val Gln Arg Glu Glu His Ala Ala
Lys Gln Ala Ala Ala Phe Ala 915 920 925 Thr Gln Thr Ile Ala Ala Ala
Gln Gly Ala Ala Ser Thr Pro Lys Ala 930 935 940 Ser Ala His Pro Gln
Pro Leu Leu Val Gln Ser Cys Ile Ala Val Ala 945 950 955 960 Glu Gln
Ile Pro Leu Leu Lys Gln Gly Val Arg Gly Ser Gln Ala Gln 965 970 975
Leu Asp Ser Pro Ser Ala Gln Leu Ala Leu Met Ala Ala Ser Gln Ser 980
985 990 Phe Leu Gln Pro Asn Gly Lys Met Val Ala Ala Ala Lys Ala Gln
Val 995 1000 1005 Pro Thr Ile Gln Asp Gln Ala Ser Arg Met Gln Leu
Ser Gln Cys Ala 1010 1015 1020 48 1024 PRT Artificial Sequence
Description of Artificial Sequence Synthetic Sequence 48 Met Val
Ala Leu Ser Leu Lys Ala Ser Ile Gly Asn Val Val Lys Thr 1 5 10 15
Met Asp Phe Glu Pro Ser Thr Met Val Tyr Asp Glu Cys Arg Ile Ile 20
25 30 Arg Glu Arg Ile Pro Phe Ala Pro Ala Gly Pro Pro Ser Asp Phe
Gly 35 40 45 Leu Phe Leu Ser Asp Asp Asp Pro Lys His Gly Ile Trp
Leu Glu Ala 50 55 60 Gly Lys Ala Ile Asp Tyr Tyr Met Leu Arg Asn
Gly Asp Lys Met Glu 65 70 75 80 Tyr Arg Lys Lys Gln Arg Pro Met Lys
Ile Arg Met Leu Asp Gly Thr 85 90 95 Val Asn Thr Ile Met Val Asp
Asp Ser Lys Thr Gln Thr Asp Met Leu 100 105 110 Met Thr Ile Cys Ala
Ser Ile Gly Ile Thr Asn His Asp Glu Tyr Thr 115 120 125 Leu Val Arg
Glu Leu Met Glu Glu Lys Val Glu Glu Ile Thr Gly Thr 130 135 140 Leu
Arg Lys Trp Lys Thr Leu Leu Arg Asp Glu Lys Lys Tyr Glu Lys 145 150
155 160 Leu Lys Gln Lys Leu His Thr Ala Asp Glu Leu Asn Trp Leu Asp
His 165 170 175 Gly Asp Thr Leu Arg Glu Gln Gly Val Glu Glu Glu Glu
Thr Leu Leu 180 185 190 Leu Arg Arg Lys Phe Phe Tyr Ser Asp Gln Asn
Val Asp Ser Arg Gly 195 200 205 Pro Val Gln Leu Asn Leu Leu Tyr Val
His Ala Arg Asp Asp Ile Leu 210 215 220 Asn Gly Ser Ile Pro Val Ser
Phe Asp Lys Ala Cys Glu Lys Ala Gly 225 230 235 240 Phe Gln Cys Gln
Ile Gln Phe Leu Pro His Asn Glu Gln Lys His Lys 245 250 255 Ala Met
Phe Leu Asp Leu Lys Asp Phe Leu Pro Asn Glu Tyr Val Lys 260 265 270
Gln Lys Gly Glu Arg Gln Ile Phe Gln Ala His Lys Asn Cys Gly Arg 275
280 285 Met Ser Glu Ile Glu Ala Lys Val Arg Ser Val Lys Leu Ala Arg
Ser 290 295 300 Leu Lys Thr Thr Gly Val Ser Phe Phe Leu Val Lys Glu
Val Met Lys 305 310 315 320 Gly Lys Asn Lys Leu Val Pro Trp Leu Leu
Gly Ile Thr Lys Glu Cys 325 330 335 Val Tyr Arg Val Asp Glu Lys Thr
Lys Glu Val Ala Gln Glu Trp Asn 340 345 350 Leu Thr Asn Ile Lys Asp
Trp Ala Ala Ser Pro Lys Ser Phe Thr Glu 355 360 365 Asp Phe Gly Asp
Tyr Gln Asp Gly Tyr Phe Ser Val Gln Thr Thr Glu 370 375 380 Gly Glu
Gln Gly Ala Gln Leu Ile Ala Gly Tyr Ile Asp His Ile Leu 385 390 395
400 Lys Lys Lys Lys Ser Lys Asp Ile Phe Gly Leu Glu Gly Asp Glu Glu
405 410 415 Ser Lys Met Leu Glu Asp Ser Val Ser Pro Lys Leu Ser Thr
Val Leu 420 425 430 Gln Gln Gln Tyr Asn Met Val Gly Lys Val Glu His
Gly Ser Val Asn 435 440 445 Leu Pro Ala Ile Met Arg Ser Gly Ala Gln
Gly Pro Glu Asn Phe Gln 450 455 460 Val Gly Ser Arg Pro Pro Ala Gln
Gln Gln Ile Thr Ser Ser Gln Met 465 470 475 480 His Arg Gly His Met
Pro Pro Thr Thr Ser Ala Gln Gln Ala Leu Thr 485 490 495 Gly Val Ile
Asn Ser Ser Met Gln Ala Val Gln Trp Ala Gln Ala Thr 500 505 510 Leu
Asp Asp Phe Asp Tyr Leu Pro Pro Leu Gly Gln Asp Ala Ala Ala 515 520
525 Lys Ala Trp Arg Lys Asn Lys Met Asp Asp Ser Lys His Glu Ile His
530 535 540 Ser Gln Val Glu Ala Ile Thr Ala Gly Thr Ala Ser Val Phe
Asn Leu 545 550 555 560 Thr Ala Gly Asp Pro Ala Glu Gly Asp Tyr Thr
Ala Val Gly Cys Ala 565 570 575 Val His Thr Ile Ser Ser Asn Leu Thr
Glu Met Ile Arg Gly Val Lys 580 585 590 Leu Leu Ala Ala Leu Lys Glu
Asp Glu Gly Gly Ser Gly Arg Pro Met 595 600 605 Leu Gln Ala Ala Lys
Gly Leu Ala Gly Asn Val Ser Glu Leu Leu Arg 610 615 620 Ser Ala Gln
Gln Ala Ser Ala Glu Pro Arg Gln Asn Leu Arg Gln Ala 625 630 635 640
Ala Gly Asn Val Gly Gln Ala Ser Gly Glu Leu Leu Gln Gln Ile Gly 645
650 655 Glu Thr Asp Thr Asp Pro His Phe Gln Asp Ala Val Met Gln Leu
Ala 660 665 670 Lys Ala Val Ala Ser Trp Ala Ala Ala Leu Val Leu Lys
Ala Lys Tyr 675 680 685 Val Ala Gln Arg Thr Glu Asp Ser Gly Ala Gln
Thr Gln Val Ile Ala 690 695 700 Ala Ala Thr Asp Cys Ala Leu Ser Thr
Ser Gln Leu Val Glu Cys Thr 705 710 715 720 Lys Val Val Ala Pro Thr
Ile Phe Ser Pro Val Cys Gln Glu Gln Leu 725 730 735 Val Gly Ala Gly
Arg Leu Val Ala Lys Ala Val His Gly Cys Val Ser 740 745 750 Ala Ser
Gln Ala Ala Ile Glu Asp Gly Gln Leu Leu Arg Gly Val Lys 755 760 765
Ala Ala Ala Thr Ala Val Thr Gln Ala Met Asn Glu Leu Leu Gln His 770
775 780 Val Lys Ala Asn Ala Thr Gly Ala Gly Pro Ala Gly Arg Gln Asp
Gln 785 790 795 800 Ala Thr Asp Thr Ile Leu Thr Arg Thr Glu Asn Ile
Phe Ser Ser Met 805 810 815 Gly Ser Ala Gly Glu Met Val Gly Gln Ala
Arg Thr Leu Ala Gln Ala 820 825 830 Thr Ser Asp Leu Val Val Ala Ile
Lys Ala Asp Ala Glu Gly Glu Trp 835 840 845 Asp Leu Glu Asn Ser Arg
Lys Leu Leu Tyr Ala Ala Lys Ile Leu Ala 850 855 860 Asp Ala Thr Asp
Lys Met Val Glu Ala Ala Lys Gly Ala Glu Ala His 865 870 875 880 Pro
Asp Ser Glu Glu Gln Gln Phe Arg Leu Arg Glu Ala Ala Glu Gly 885 890
895 Leu Gly Met Ala Thr Asn Ala Ala Ala Gln Asn His Ile Lys Lys Lys
900 905 910 Leu Val Gln Arg Leu Ile His Ala Ala Lys Gln Ala Ala Ala
Ser Lys 915 920 925 Thr Gln Thr Ile Ala Ala Ala Gln His Leu Ala Ser
Thr Pro Lys Ala 930 935 940 Ser Ala Gly Met Gln Pro Leu Leu Val Gln
Ser Cys Lys Asn Val Ala 945 950 955 960 Glu Gln Ile Pro Leu Leu Val
Arg Gly Val Arg Gly Ser Gln Ala Gln 965 970 975 Pro Ser Ser Pro Ser
Ala Gln Leu Ala Leu Ile Thr Ala Ser Gln Ser 980 985 990 Phe Leu Gln
Pro Gly Val Lys Met Val Ala Ala Ala Lys Ala Ser Trp 995 1000 1005
Pro Thr Ile Gln Asp Gln Ala Ser Ala Tyr Gln Leu Ser Gln Cys Ala
1010 1015 1020 49 1024 PRT Artificial Sequence Description of
Artificial Sequence Synthetic Sequence 49 Met Val Ala Leu Ser Leu
Lys Ile Ala Ile Gly Asn Val Val Lys Thr 1 5 10 15 Met Gln Asp Glu
Pro Ser Thr Met Val Tyr Asp Ala Glu Arg Ile Ile 20 25 30 Arg Glu
Arg Ile Pro Glu Phe Pro Ala Gly Pro Pro Ser Asp Phe Gly 35 40
45 Gly Phe Leu Ser Asp Asp Asp Pro Lys Lys His Ile Trp Leu Glu Ala
50 55 60 Gly Lys Ala Leu Ile Tyr Tyr Met Leu Arg Asn Gly Asp Thr
Lys Glu 65 70 75 80 Tyr Arg Lys Lys Gln Arg Pro Leu Leu Ile Arg Met
Leu Asp Gly Thr 85 90 95 Val Lys Met Ile Met Val Asp Asp Ser Lys
Thr Val Asn Asp Met Leu 100 105 110 Met Thr Ile Cys Ala Arg Gln Gly
Ile Thr Asn His Asp Glu Tyr Ser 115 120 125 Arg Val Arg Glu Leu Met
Glu Glu Lys Lys Ser Glu Ile Thr Gly Thr 130 135 140 Leu Arg Lys Asp
Thr Thr Leu Leu Arg Asp Glu Lys Lys Met Val Lys 145 150 155 160 Leu
Lys Gln Lys Leu His Thr Asp Trp Glu Leu Asn Trp Leu Asp His 165 170
175 Gly Arg Tyr Leu Arg Glu Gln Gly Val Glu Glu His Ala Thr Leu Leu
180 185 190 Leu Arg Arg Lys Phe Phe Asp Ser Asp Gln Asn Val Asp Ser
Arg Asp 195 200 205 Glu Val Gln Leu Asn Leu Leu Tyr Val Gln Phe Arg
Asp Asp Ile Leu 210 215 220 Asn Gly Ser His Gly Val Ser Phe Asp Lys
Ala Cys Glu Phe His Gly 225 230 235 240 Phe Gln Cys Gln Ile Gln Phe
Gly Ile His Asn Glu Gln Lys His Lys 245 250 255 Ala Gly Lys Leu Asp
Leu Lys Asp Phe Leu Pro Lys Leu Tyr Val Lys 260 265 270 Gln Lys Gly
Glu Arg Lys Met Phe Gln Ala His Lys Asn Cys Gly Gln 275 280 285 Asn
Ser Glu Ile Glu Ala Lys Val Arg Tyr Gln Lys Leu Ala Arg Ser 290 295
300 Leu Lys Thr Tyr Arg Val Ser Phe Phe Leu Val Lys Glu Lys Ser Lys
305 310 315 320 Gly Lys Asn Lys Leu Val Pro Arg Thr Leu Gly Ile Thr
Lys Glu Cys 325 330 335 Val Met Val Val Asp Glu Lys Thr Lys Glu Val
Ile Trp Glu Trp Asn 340 345 350 Leu Thr Asn Ile Lys Arg Tyr Ala Ala
Ser Pro Lys Ser Phe Thr Leu 355 360 365 Ala Phe Gly Asp Tyr Gln Asp
Gly Tyr Tyr Asp Val Gln Thr Thr Glu 370 375 380 Gly Glu Gln Ile Glu
Gln Leu Ile Ala Gly Tyr Ile Asp Ile Phe Leu 385 390 395 400 Lys Lys
Lys Lys Ser Lys Asp His Gly Gly Leu Glu Gly Asp Glu Glu 405 410 415
Ser Thr His Leu Glu Asp Ser Val Ser Pro Lys Lys Ile Thr Val Leu 420
425 430 Gln Gln Gln Tyr Asn Arg Lys Gly Lys Val Glu His Gly Ser Val
Ala 435 440 445 Met Pro Ala Ile Met Arg Ser Gly Ala Ser Asn Pro Glu
Asn Phe Gln 450 455 460 Val Gly Ser Met Gln Pro Ala Gln Gln Gln Ile
Thr Ser Gly Arg Met 465 470 475 480 His Arg Gly His Met Pro Pro Leu
Ser Ser Ala Gln Gln Ala Leu Thr 485 490 495 Gly Thr Thr Asn Ser Ser
Met Gln Ala Val Gln Ala Val Gln Ala Thr 500 505 510 Leu Asp Asp Phe
Asp Thr Trp Pro Pro Leu Gly Gln Asp Ala Ala Ser 515 520 525 Tyr Ala
Trp Arg Lys Asn Lys Met Asp Glu Ala Lys His Glu Ile His 530 535 540
Ser Gln Val Asp Asp Ile Thr Ala Gly Thr Ala Ser Val Val Glu Leu 545
550 555 560 Thr Ala Gly Asp Pro Ala Glu Thr Phe Tyr Thr Ala Val Gly
Cys Ala 565 570 575 Val Thr Gly Ile Ser Ser Asn Leu Thr Glu Met Ser
His Gly Val Lys 580 585 590 Leu Leu Ala Ala Leu Leu Ile Asp Glu Gly
Gly Ser Gly Arg Pro Leu 595 600 605 Lys Gln Ala Ala Lys Gly Leu Ala
Gly Ala Leu Ser Glu Leu Leu Arg 610 615 620 Ser Ala Gln Pro Met Ser
Ala Glu Pro Arg Gln Asn Leu Leu Asn Ala 625 630 635 640 Ala Gly Asn
Val Gly Gln Ala Ser Gln Glu Leu Leu Gln Gln Ile Gly 645 650 655 Glu
Ser Arg Thr Asp Pro His Phe Gln Asp Ala Leu Ser Gln Leu Ala 660 665
670 Lys Ala Val Ala Ser Ala Thr Ala Ala Leu Val Leu Lys Ala Lys Ser
675 680 685 Trp Ala Gln Arg Thr Glu Asp Ser Gly Leu Tyr Thr Gln Val
Ile Ala 690 695 700 Ala Ala Thr Gln Ala Ala Leu Ser Thr Ser Gln Leu
Val Ala Asp Thr 705 710 715 720 Lys Val Val Ala Pro Thr Ile Ser Glu
Pro Val Cys Gln Glu Gln Leu 725 730 735 Val Glu Phe Gly Arg Leu Val
Ala Lys Ala Val Glu His Cys Val Ser 740 745 750 Ala Ser Gln Ala Ala
Thr Ile Asp Gly Gln Leu Leu Arg Gly Val Gly 755 760 765 Lys Ala Ala
Thr Ala Val Thr Gln Ala Leu Leu Glu Leu Leu Gln His 770 775 780 Val
Lys Ala His Met Thr Gly Ala Gly Pro Ala Gly Arg Tyr Asn Gln 785 790
795 800 Ala Thr Asp Thr Ile Leu Thr Val Gln Glu Asn Ile Phe Ser Ser
Met 805 810 815 Gly Asp Arg Gly Glu Met Val Gly Gln Ala Arg Ile Ser
Ala Gln Ala 820 825 830 Thr Ser Asp Leu Val Asn Thr Ile Lys Ala Asp
Ala Glu Gly Glu Ser 835 840 845 Val Leu Glu Asn Ser Arg Lys Leu Leu
Ser Trp Ala Lys Ile Leu Ala 850 855 860 Asp Ala Thr Ala Tyr Met Val
Glu Ala Ala Lys Gly Ala Ala Asp His 865 870 875 880 Pro Asp Ser Glu
Glu Gln Gln Gln Glu Leu Arg Glu Ala Ala Glu Gly 885 890 895 Leu Arg
Phe Ala Thr Asn Ala Ala Ala Gln Asn Ala Gly Lys Lys Lys 900 905 910
Leu Val Gln Arg Leu Glu Ile Ala Ala Lys Gln Ala Ala Ala Ser Ala 915
920 925 Lys Gln Thr Ile Ala Ala Ala Gln His Ala Leu Ser Thr Pro Lys
Ala 930 935 940 Ser Ala Gly Pro Met Pro Leu Leu Val Gln Ser Cys Lys
Ala Asn Ala 945 950 955 960 Glu Gln Ile Pro Leu Leu Val Gln Gln Val
Arg Gly Ser Gln Ala Gln 965 970 975 Pro Asp Arg Pro Ser Ala Gln Leu
Ala Leu Ile Ala Ser Ser Gln Ser 980 985 990 Phe Leu Gln Pro Gly Gly
Thr Met Val Ala Ala Ala Lys Ala Ser Val 995 1000 1005 Val Thr Ile
Gln Asp Gln Ala Ser Ala Met Trp Leu Ser Gln Cys Ala 1010 1015 1020
50 1024 PRT Artificial Sequence Description of Artificial Sequence
Synthetic Sequence 50 Met Val Ala Leu Ser Leu Lys Ile Ser Ala Gly
Asn Val Val Lys Thr 1 5 10 15 Met Gln Phe Asp Pro Ser Thr Met Val
Tyr Asp Ala Cys Glu Ile Ile 20 25 30 Arg Glu Arg Ile Pro Glu Ala
Phe Ala Gly Pro Pro Ser Asp Phe Gly 35 40 45 Leu Gly Leu Ser Asp
Asp Asp Pro Lys Lys Gly His Trp Leu Glu Ala 50 55 60 Gly Lys Ala
Leu Asp Ile Tyr Met Leu Arg Asn Gly Asp Thr Met Lys 65 70 75 80 Tyr
Arg Lys Lys Gln Arg Pro Leu Lys Leu Arg Met Leu Asp Gly Thr 85 90
95 Val Lys Thr Met Met Val Asp Asp Ser Lys Thr Val Thr Asn Met Leu
100 105 110 Met Thr Ile Cys Ala Arg Ile Gln Ile Thr Asn His Asp Glu
Tyr Ser 115 120 125 Leu Arg Arg Glu Leu Met Glu Glu Lys Lys Glu Ser
Ile Thr Gly Thr 130 135 140 Leu Arg Lys Asp Lys Val Leu Leu Arg Asp
Glu Lys Lys Met Glu Trp 145 150 155 160 Leu Lys Gln Lys Leu His Thr
Asp Asp Tyr Leu Asn Trp Leu Asp His 165 170 175 Gly Arg Thr Ala Arg
Glu Gln Gly Val Glu Glu His Glu Asp Leu Leu 180 185 190 Leu Arg Arg
Lys Phe Phe Tyr Glu Asp Gln Asn Val Asp Ser Arg Asp 195 200 205 Pro
Phe Gln Leu Asn Leu Leu Tyr Val Gln Ala Gly Asp Asp Ile Leu 210 215
220 Asn Gly Ser His Pro His Ser Phe Asp Lys Ala Cys Glu Phe Ala Ile
225 230 235 240 Phe Gln Cys Gln Ile Gln Phe Gly Pro Lys Asn Glu Gln
Lys His Lys 245 250 255 Ala Gly Phe Met Asp Leu Lys Asp Phe Leu Pro
Lys Glu Asn Val Lys 260 265 270 Gln Lys Gly Glu Arg Lys Ile Gln Gln
Ala His Lys Asn Cys Gly Gln 275 280 285 Met Arg Glu Ile Glu Ala Lys
Val Arg Tyr Val Ser Leu Ala Arg Ser 290 295 300 Leu Lys Thr Tyr Gly
Thr Ser Phe Phe Leu Val Lys Glu Lys Met Val 305 310 315 320 Gly Lys
Asn Lys Leu Val Pro Arg Leu Trp Gly Ile Thr Lys Glu Cys 325 330 335
Val Met Arg Tyr Asp Glu Lys Thr Lys Glu Val Ile Gln Ala Trp Asn 340
345 350 Leu Thr Asn Ile Lys Arg Trp Asp Ala Ser Pro Lys Ser Phe Thr
Leu 355 360 365 Asp Glu Gly Asp Tyr Gln Asp Gly Tyr Tyr Ser Phe Gln
Thr Thr Glu 370 375 380 Gly Glu Gln Ile Ala Gly Leu Ile Ala Gly Tyr
Ile Asp Ile Ile His 385 390 395 400 Lys Lys Lys Lys Ser Lys Asp His
Phe Ile Leu Glu Gly Asp Glu Glu 405 410 415 Ser Thr Met Lys Glu Asp
Ser Val Ser Pro Lys Lys Ser Leu Val Leu 420 425 430 Gln Gln Gln Tyr
Asn Arg Val Met Lys Val Glu His Gly Ser Val Ala 435 440 445 Leu Asn
Ala Ile Met Arg Ser Gly Ala Ser Gly Gln Glu Asn Phe Gln 450 455 460
Val Gly Ser Met Pro Arg Ala Gln Gln Gln Ile Thr Ser Gly Gln Ser 465
470 475 480 His Arg Gly His Met Pro Pro Leu Thr Thr Ala Gln Gln Ala
Leu Thr 485 490 495 Gly Thr Ile Val Ser Ser Met Gln Ala Val Gln Ala
Ala Trp Ala Thr 500 505 510 Leu Asp Asp Phe Asp Thr Leu Tyr Pro Leu
Gly Gln Asp Ala Ala Ser 515 520 525 Lys Asp Trp Arg Lys Asn Lys Met
Asp Glu Ser Glu His Glu Ile His 530 535 540 Ser Gln Val Asp Ala Phe
Thr Ala Gly Thr Ala Ser Val Val Asn Gly 545 550 555 560 Thr Ala Gly
Asp Pro Ala Glu Thr Asp His Thr Ala Val Gly Cys Ala 565 570 575 Val
Thr Thr Lys Ser Ser Asn Leu Thr Glu Met Ser Arg Leu Val Lys 580 585
590 Leu Leu Ala Ala Leu Leu Glu Met Glu Gly Gly Ser Gly Arg Pro Leu
595 600 605 Leu Asn Ala Ala Lys Gly Leu Ala Gly Ala Val Gln Glu Leu
Leu Arg 610 615 620 Ser Ala Gln Pro Ala Arg Ala Glu Pro Arg Gln Asn
Leu Leu Gln Ser 625 630 635 640 Ala Gly Asn Val Gly Gln Ala Ser Gly
Thr Leu Leu Gln Gln Ile Gly 645 650 655 Glu Ser Asp Val Asp Pro His
Phe Gln Asp Ala Leu Met Trp Leu Ala 660 665 670 Lys Ala Val Ala Ser
Ala Ala Tyr Ala Leu Val Leu Lys Ala Lys Ser 675 680 685 Val Asp Gln
Arg Thr Glu Asp Ser Gly Leu Gln Glu Gln Val Ile Ala 690 695 700 Ala
Ala Thr Gln Cys Phe Leu Ser Thr Ser Gln Leu Val Ala Cys Gly 705 710
715 720 Lys Val Val Ala Pro Thr Ile Ser Ser His Val Cys Gln Glu Gln
Leu 725 730 735 Val Glu Ala Ile Arg Leu Val Ala Lys Ala Val Glu Gly
Lys Val Ser 740 745 750 Ala Ser Gln Ala Ala Thr Glu Leu Gly Gln Leu
Leu Arg Gly Val Gly 755 760 765 Ala Met Ala Thr Ala Val Thr Gln Ala
Leu Asn Asn Leu Leu Gln His 770 775 780 Val Lys Ala His Ala Gln Gly
Ala Gly Pro Ala Gly Arg Tyr Asp Arg 785 790 795 800 Ala Thr Asp Thr
Ile Leu Thr Val Thr Ser Asn Ile Phe Ser Ser Met 805 810 815 Gly Asp
Ala Thr Glu Met Val Gly Gln Ala Arg Ile Leu Val Gln Ala 820 825 830
Thr Ser Asp Leu Val Asn Ala Trp Lys Ala Asp Ala Glu Gly Glu Ser 835
840 845 Asp Tyr Glu Asn Ser Arg Lys Leu Leu Ser Ala Asp Lys Ile Leu
Ala 850 855 860 Asp Ala Thr Ala Lys Glu Val Glu Ala Ala Lys Gly Ala
Ala Ala Phe 865 870 875 880 Pro Asp Ser Glu Glu Gln Gln Gln Arg Gly
Arg Glu Ala Ala Glu Gly 885 890 895 Leu Arg Met His Thr Asn Ala Ala
Ala Gln Asn Ala Ile Ile Lys Lys 900 905 910 Leu Val Gln Arg Leu Glu
His Lys Ala Lys Gln Ala Ala Ala Ser Ala 915 920 925 Thr Leu Thr Ile
Ala Ala Ala Gln His Ala Ala Met Thr Pro Lys Ala 930 935 940 Ser Ala
Gly Pro Gln Asn Leu Leu Val Gln Ser Cys Lys Ala Val Gln 945 950 955
960 Glu Gln Ile Pro Leu Leu Val Gln Gly Arg Arg Gly Ser Gln Ala Gln
965 970 975 Pro Asp Ser Ser Ser Ala Gln Leu Ala Leu Ile Ala Ala Thr
Gln Ser 980 985 990 Phe Leu Gln Pro Gly Gly Lys Val Val Ala Ala Ala
Lys Ala Ser Val 995 1000 1005 Pro Trp Ile Gln Asp Gln Ala Ser Ala
Met Gln Tyr Ser Gln Cys Ala 1010 1015 1020 51 206 PRT Artificial
Sequence Description of Artificial Sequence Synthetic Sequence 51
Met Phe Leu Arg Gly Tyr Lys Arg Glu Gly Gln Val Arg Lys His Arg 1 5
10 15 Lys Ser Val Ala His Gly Gly Gly Leu Trp Gly Asn Cys Lys Ser
Tyr 20 25 30 Ala Gly Glu Ala Ala Arg Ser Leu Ile His Leu His Leu
Arg Arg Ala 35 40 45 Pro Ala Asp Pro Gly Phe Pro Pro Gly Glu Gln
Ser Asp Met Asn Gly 50 55 60 Arg Val Asp Tyr Leu Val Ser Glu Glu
Glu Ile Asn Leu Thr Arg Gly 65 70 75 80 Pro Ser Gly Leu Gly Phe Asn
Ile Val Gly Gly Thr Asp Gln Gln Tyr 85 90 95 Val Ser Asn Asp Ser
Gly Ile Tyr Val Ser Arg Ile Lys Glu Asp Gly 100 105 110 Ala Ala Ala
Arg Asp Gly Arg Leu Gln Glu Gly Asp Lys Ile Leu Ser 115 120 125 Val
Asn Gly Gln Asp Leu Lys Asn Leu Leu His Gln Asp Ala Val Asp 130 135
140 Leu Phe Arg Asn Ala Gly Tyr Ala Val Ser Leu Arg Val Gln His Arg
145 150 155 160 Leu Pro Val Gln Asn Gly Pro Ile Val His Arg Gly Asp
Gly Glu Pro 165 170 175 Ser Gly Val Pro Val Ala Val Val Leu Leu Pro
Val Phe Ala Leu Thr 180 185 190 Leu Val Ala Val Trp Ala Phe Val Arg
Tyr Arg Lys Gln Leu 195 200 205 52 206 PRT Artificial Sequence
Description of Artificial Sequence Synthetic Sequence 52 Met Ala
Leu Arg Gly Tyr Lys Arg Glu Gly Gln Asp Arg Lys His Arg 1 5 10 15
Lys Ser Val Ala His Glu Gly Gly Leu Trp Gly Asn Cys Lys Ser Phe 20
25 30 Ala Gly Glu Ala Ala Arg Ser Leu Ile Gly Leu His Leu Arg Arg
Ala 35 40 45 Pro Ala Asp His Gly Phe Pro Pro Gly Glu Gln Ser Asp
Ile Asn Gly 50 55 60 Arg Val Asp Tyr Leu Val Ser Lys Glu Glu Ile
Asn Leu Thr Arg Gly 65 70 75 80 Pro Leu Gly Leu Gly Phe Asn Ile Val
Gly Gly Met Asp Gln Gln Tyr 85 90 95 Val Ser Asn Asp Ser Asn Ile
Tyr Val Ser Arg Ile Lys Glu Asp Gln 100 105 110 Ala Ala Ala Arg Asp
Gly Arg Leu Gln Arg Gly Asp Lys Ile Leu Ser 115 120 125 Val Asn Gly
Ser Asp Leu Lys Asn Leu Leu His Gln Asp Thr Val Asp 130 135 140 Leu
Phe Arg Asn Ala Gly Tyr Val Val Ser Leu Arg Val Gln His Arg 145 150
155 160 Leu Trp Val Gln Asn Gly Pro Ile Val His Arg Tyr Asp Gly Glu
Pro 165 170 175 Ser Gly Val Pro Val Asp Val Val Leu Leu Pro Val Phe
Ala Leu Glu 180 185 190 Leu Val Ala Val Trp Ala Phe Val Arg Phe Arg
Lys Gln Leu 195 200 205 53 206
PRT Artificial Sequence Description of Artificial Sequence
Synthetic Sequence 53 Met Phe Ala Arg Gly Tyr Lys Arg Glu Gly Gln
Val Asp Lys His Arg 1 5 10 15 Lys Ser Val Ala His Gly Asp Gly Leu
Trp Gly Asn Cys Lys Ser Tyr 20 25 30 Phe Gly Glu Ala Ala Arg Ser
Leu Ile His Gly His Leu Arg Arg Ala 35 40 45 Pro Ala Asp Pro His
Phe Pro Pro Gly Glu Gln Ser Asp Met Ile Gly 50 55 60 Arg Val Asp
Tyr Leu Val Ser Glu Lys Glu Ile Asn Leu Thr Arg Gly 65 70 75 80 Pro
Ser Leu Leu Gly Phe Asn Ile Val Gly Gly Thr Met Gln Gln Tyr 85 90
95 Val Ser Asn Asp Ser Gly Asn Tyr Val Ser Arg Ile Lys Glu Asp Gly
100 105 110 Gln Ala Ala Arg Asp Gly Arg Leu Gln Glu Arg Asp Lys Ile
Leu Ser 115 120 125 Val Asn Gly Gln Ser Leu Lys Asn Leu Leu His Gln
Asp Ala Thr Asp 130 135 140 Leu Phe Arg Asn Ala Gly Tyr Ala Trp Ser
Leu Arg Val Gln His Arg 145 150 155 160 Leu Pro Tyr Gln Asn Gly Pro
Ile Val His Arg Gly Ala Gly Glu Pro 165 170 175 Ser Gly Val Pro Val
Ala Asp Val Leu Leu Pro Val Phe Ala Leu Thr 180 185 190 Glu Val Ala
Val Trp Ala Phe Val Arg Tyr Phe Lys Gln Leu 195 200 205 54 206 PRT
Artificial Sequence Description of Artificial Sequence Synthetic
Sequence 54 Met Phe Leu Ala Gly Tyr Lys Arg Glu Gly Gln Val Arg Asp
His Arg 1 5 10 15 Lys Ser Val Ala His Gly Gly Asp Leu Trp Gly Asn
Cys Lys Ser Tyr 20 25 30 Ala Phe Glu Ala Ala Arg Ser Leu Ile His
Leu Gly Leu Arg Arg Ala 35 40 45 Pro Ala Asp Pro Gly His Pro Pro
Gly Glu Gln Ser Asp Met Asn Ile 50 55 60 Arg Val Asp Tyr Leu Val
Ser Glu Glu Lys Ile Asn Leu Thr Arg Gly 65 70 75 80 Pro Ser Gly Met
Gly Phe Asn Ile Val Gly Gly Thr Asp Asn Gln Tyr 85 90 95 Val Ser
Asn Asp Ser Gly Ile Gln Val Ser Arg Ile Lys Glu Asp Gly 100 105 110
Ala Arg Ala Arg Asp Gly Arg Leu Gln Glu Gly Ser Lys Ile Leu Ser 115
120 125 Val Asn Gly Gln Asp Thr Lys Asn Leu Leu His Gln Asp Ala Val
Val 130 135 140 Leu Phe Arg Asn Ala Gly Tyr Ala Val Trp Leu Arg Val
Gln His Arg 145 150 155 160 Leu Pro Val Tyr Asn Gly Pro Ile Val His
Arg Gly Asp Ala Glu Pro 165 170 175 Ser Gly Val Pro Val Ala Val Asp
Leu Leu Pro Val Phe Ala Leu Thr 180 185 190 Leu Glu Ala Val Trp Ala
Phe Val Arg Tyr Arg Phe Gln Leu 195 200 205 55 206 PRT Artificial
Sequence Description of Artificial Sequence Synthetic Sequence 55
Met Phe Leu Arg Ala Tyr Lys Arg Glu Gly Gln Val Arg Lys Asp Arg 1 5
10 15 Lys Ser Val Ala His Gly Gly Gly Glu Trp Gly Asn Cys Lys Ser
Tyr 20 25 30 Ala Gly Phe Ala Ala Arg Ser Leu Ile His Leu His Gly
Arg Arg Ala 35 40 45 Pro Ala Asp Pro Gly Phe His Pro Gly Glu Gln
Ser Asp Met Asn Gly 50 55 60 Ile Val Asp Tyr Leu Val Ser Glu Glu
Glu Lys Asn Leu Thr Arg Gly 65 70 75 80 Pro Ser Gly Leu Leu Phe Asn
Ile Val Gly Gly Thr Asp Gln Met Tyr 85 90 95 Val Ser Asn Asp Ser
Gly Ile Tyr Asn Ser Arg Ile Lys Glu Asp Gly 100 105 110 Ala Ala Gln
Arg Asp Gly Arg Leu Gln Glu Gly Asp Arg Ile Leu Ser 115 120 125 Val
Asn Gly Gln Asp Leu Ser Asn Leu Leu His Gln Asp Ala Val Asp 130 135
140 Thr Phe Arg Asn Ala Gly Tyr Ala Val Ser Val Arg Val Gln His Arg
145 150 155 160 Leu Pro Val Gln Trp Gly Pro Ile Val His Arg Gly Asp
Gly Tyr Pro 165 170 175 Ser Gly Val Pro Val Ala Val Val Ala Leu Pro
Val Phe Ala Leu Thr 180 185 190 Leu Val Asp Val Trp Ala Phe Val Arg
Tyr Arg Lys Glu Leu 195 200 205 56 206 PRT Artificial Sequence
Description of Artificial Sequence Synthetic Sequence 56 Met Phe
Leu Arg Gly Ala Lys Arg Glu Gly Gln Val Arg Lys His Asp 1 5 10 15
Lys Ser Val Ala His Gly Gly Gly Leu Glu Gly Asn Cys Lys Ser Tyr 20
25 30 Ala Gly Glu Phe Ala Arg Ser Leu Ile His Leu His Leu Gly Arg
Ala 35 40 45 Pro Ala Asp Pro Gly Phe Pro His Gly Glu Gln Ser Asp
Met Asn Gly 50 55 60 Arg Ile Asp Tyr Leu Val Ser Glu Glu Glu Ile
Lys Leu Thr Arg Gly 65 70 75 80 Pro Ser Gly Leu Gly Leu Asn Ile Val
Gly Gly Thr Asp Gln Gln Met 85 90 95 Val Ser Asn Asp Ser Gly Ile
Tyr Val Asn Arg Ile Lys Glu Asp Gly 100 105 110 Ala Ala Ala Gln Asp
Gly Arg Leu Gln Glu Gly Asp Lys Arg Leu Ser 115 120 125 Val Asn Gly
Gln Asp Leu Lys Ser Leu Leu His Gln Asp Ala Val Asp 130 135 140 Leu
Thr Arg Asn Ala Gly Tyr Ala Val Ser Leu Val Val Gln His Arg 145 150
155 160 Leu Pro Val Gln Asn Trp Pro Ile Val His Arg Gly Asp Gly Glu
Tyr 165 170 175 Ser Gly Val Pro Val Ala Val Val Leu Ala Pro Val Phe
Ala Leu Thr 180 185 190 Leu Val Ala Asp Trp Ala Phe Val Arg Tyr Arg
Lys Gln Glu 195 200 205 57 206 PRT Artificial Sequence Description
of Artificial Sequence Synthetic Sequence 57 Met Phe Leu Arg Gly
Tyr Ala Arg Glu Gly Gln Val Arg Lys His Arg 1 5 10 15 Asp Ser Val
Ala His Gly Gly Gly Leu Trp Glu Asn Cys Lys Ser Tyr 20 25 30 Ala
Gly Glu Ala Phe Arg Ser Leu Ile His Leu His Leu Arg Gly Ala 35 40
45 Pro Ala Asp Pro Gly Phe Pro Pro His Glu Gln Ser Asp Met Asn Gly
50 55 60 Arg Val Ile Tyr Leu Val Ser Glu Glu Glu Ile Asn Lys Thr
Arg Gly 65 70 75 80 Pro Ser Gly Leu Gly Phe Leu Ile Val Gly Gly Thr
Asp Gln Gln Tyr 85 90 95 Met Ser Asn Asp Ser Gly Ile Tyr Val Ser
Asn Ile Lys Glu Asp Gly 100 105 110 Ala Ala Ala Arg Gln Gly Arg Leu
Gln Glu Gly Asp Lys Ile Arg Ser 115 120 125 Val Asn Gly Gln Asp Leu
Lys Asn Ser Leu His Gln Asp Ala Val Asp 130 135 140 Leu Phe Thr Asn
Ala Gly Tyr Ala Val Ser Leu Arg Trp Gln His Arg 145 150 155 160 Leu
Pro Val Gln Asn Gly Tyr Ile Val His Arg Gly Asp Gly Glu Pro 165 170
175 Ala Gly Val Pro Val Ala Val Val Leu Leu Asp Val Phe Ala Leu Thr
180 185 190 Leu Val Ala Val Glu Ala Phe Val Arg Tyr Arg Lys Gln Leu
195 200 205 58 206 PRT Artificial Sequence Description of
Artificial Sequence Synthetic Sequence 58 Met Phe Leu Arg Gly Tyr
Lys Ala Glu Gly Gln Val Arg Lys His Arg 1 5 10 15 Lys Asp Val Ala
His Gly Gly Gly Leu Trp Gly Glu Cys Lys Ser Tyr 20 25 30 Ala Gly
Glu Ala Ala Phe Ser Leu Ile His Leu His Leu Arg Arg Gly 35 40 45
Pro Ala Asp Pro Gly Phe Pro Pro Gly His Gln Ser Asp Met Asn Gly 50
55 60 Arg Val Asp Ile Leu Val Ser Glu Glu Glu Ile Asn Leu Lys Arg
Gly 65 70 75 80 Pro Ser Gly Leu Gly Phe Asn Leu Val Gly Gly Thr Asp
Gln Gln Tyr 85 90 95 Val Met Asn Asp Ser Gly Ile Tyr Val Ser Arg
Asn Lys Glu Asp Gly 100 105 110 Ala Ala Ala Arg Asp Gln Arg Leu Gln
Glu Gly Asp Lys Ile Leu Arg 115 120 125 Val Asn Gly Gln Asp Leu Lys
Asn Leu Ser His Gln Asp Ala Val Asp 130 135 140 Leu Phe Arg Thr Ala
Gly Tyr Ala Val Ser Leu Arg Val Val His Arg 145 150 155 160 Leu Pro
Val Gln Asn Gly Pro Trp Val His Arg Gly Asp Gly Glu Pro 165 170 175
Ser Tyr Val Pro Val Ala Val Val Leu Leu Pro Ala Phe Ala Leu Thr 180
185 190 Leu Val Ala Val Trp Asp Phe Val Arg Tyr Arg Lys Gln Leu 195
200 205 59 206 PRT Artificial Sequence Description of Artificial
Sequence Synthetic Sequence 59 Met Phe Leu Arg Gly Tyr Lys Arg Ala
Gly Gln Val Arg Lys His Arg 1 5 10 15 Lys Ser Asp Ala His Gly Gly
Gly Leu Trp Gly Asn Glu Lys Ser Tyr 20 25 30 Ala Gly Glu Ala Ala
Arg Phe Leu Ile His Leu His Leu Arg Arg Ala 35 40 45 Gly Ala Asp
Pro Gly Phe Pro Pro Gly Glu His Ser Asp Met Asn Gly 50 55 60 Arg
Val Asp Tyr Ile Val Ser Glu Glu Glu Ile Asn Leu Thr Lys Gly 65 70
75 80 Pro Ser Gly Leu Gly Phe Asn Ile Leu Gly Gly Thr Asp Gln Gln
Tyr 85 90 95 Val Ser Met Asp Ser Gly Ile Tyr Val Ser Arg Ile Asn
Glu Asp Gly 100 105 110 Ala Ala Ala Arg Asp Gly Gln Leu Gln Glu Gly
Asp Lys Ile Leu Ser 115 120 125 Arg Asn Gly Gln Asp Leu Lys Asn Leu
Leu Ser Gln Asp Ala Val Asp 130 135 140 Leu Phe Arg Asn Thr Gly Tyr
Ala Val Ser Leu Arg Val Gln Val Arg 145 150 155 160 Leu Pro Val Gln
Asn Gly Pro Ile Trp His Arg Gly Asp Gly Glu Pro 165 170 175 Ser Gly
Tyr Pro Val Ala Val Val Leu Leu Pro Val Ala Ala Leu Thr 180 185 190
Leu Val Ala Val Trp Ala Asp Val Arg Tyr Arg Lys Gln Leu 195 200 205
60 206 PRT Artificial Sequence Description of Artificial Sequence
Synthetic Sequence 60 Met Phe Leu Arg Gly Tyr Lys Arg Glu Ala Gln
Val Arg Lys His Arg 1 5 10 15 Lys Ser Val Asp His Gly Gly Gly Leu
Trp Gly Asn Cys Glu Ser Tyr 20 25 30 Ala Gly Glu Ala Ala Arg Ser
Phe Ile His Leu His Leu Arg Arg Ala 35 40 45 Pro Gly Asp Pro Gly
Phe Pro Pro Gly Glu Gln His Asp Met Asn Gly 50 55 60 Arg Val Asp
Tyr Leu Ile Ser Glu Glu Glu Ile Asn Leu Thr Arg Lys 65 70 75 80 Pro
Ser Gly Leu Gly Phe Asn Ile Val Leu Gly Thr Asp Gln Gln Tyr 85 90
95 Val Ser Asn Met Ser Gly Ile Tyr Val Ser Arg Ile Lys Asn Asp Gly
100 105 110 Ala Ala Ala Arg Asp Gly Arg Gln Gln Glu Gly Asp Lys Ile
Leu Ser 115 120 125 Val Arg Gly Gln Asp Leu Lys Asn Leu Leu His Ser
Asp Ala Val Asp 130 135 140 Leu Phe Arg Asn Ala Thr Tyr Ala Val Ser
Leu Arg Val Gln His Val 145 150 155 160 Leu Pro Val Gln Asn Gly Pro
Ile Val Trp Arg Gly Asp Gly Glu Pro 165 170 175 Ser Gly Val Tyr Val
Ala Val Val Leu Leu Pro Val Phe Asp Leu Thr 180 185 190 Leu Val Ala
Val Trp Ala Phe Glu Arg Tyr Arg Lys Gln Leu 195 200 205 61 503 PRT
Artificial Sequence Description of Artificial Sequence Synthetic
Sequence 61 Met Pro Ser Lys Thr Lys Tyr Asn Leu Val Asp Asp Gly His
Asp Leu 1 5 10 15 Arg Ile Pro Leu His Asn Glu Asp Ala Phe Gln His
Gly Ile Ser Phe 20 25 30 Glu Ala Lys Tyr Val Gly Ser Leu Asp Val
Pro Arg Pro Asn Ser Arg 35 40 45 Val Glu Ile Val Ala Ala Met Arg
Arg Ile Arg Tyr Glu Phe Lys Ala 50 55 60 Lys Asn Ile Lys Lys Lys
Lys Val Ser Ile Met Val Ser Val Asp Gly 65 70 75 80 Val Lys Val Ile
Leu Lys Lys Lys Lys Lys Lys Lys Glu Trp Thr Trp 85 90 95 Asp Glu
Ser Lys Met Leu Val Met Gln Asp Pro Ile Tyr Arg Ile Phe 100 105 110
Tyr Val Ser His Asp Ser Gln Asp Leu Lys Ile Phe Ser Tyr Ile Ala 115
120 125 Arg Asp Gly Ala Ser Asn Ile Phe Arg Cys Asn Val Phe Lys Ser
Lys 130 135 140 Lys Lys Ser Gln Ala Met Arg Ile Val Arg Thr Val Gly
Gln Ala Phe 145 150 155 160 Glu Val Cys His Lys Leu Ser Leu Gln His
Thr Gln Gln Asn Ala Asp 165 170 175 Gly Gln Glu Asp Gly Glu Ser Glu
Arg Asn Ser Asp Gly Ser Gly Asp 180 185 190 Pro Gly Arg Gln Leu Thr
Gly Ala Glu Arg Val Ser Thr Ala Thr Ala 195 200 205 Glu Glu Thr Asp
Ile Asp Ala Val Glu Val Pro Leu Pro Gly Asn Asp 210 215 220 Ile Leu
Glu Phe Ser Arg Gly Val Thr Asp Leu Asp Ala Ile Gly Lys 225 230 235
240 Asp Gly Gly Ser His Ile Asp Thr Thr Val Ser Pro His Pro Gln Glu
245 250 255 Pro Met Leu Ala Ala Ser Pro Arg Met Leu Leu Pro Ser Ser
Ser Ser 260 265 270 Ser Lys Pro Pro Gly Leu Gly Thr Gly Thr Pro Leu
Ser Thr His His 275 280 285 Gln Met Gln Leu Leu Gln Gln Leu Leu Gln
Gln Gln Gln Gln Gln Thr 290 295 300 Gln Val Ala Val Ala Gln Val His
Leu Leu Lys Asp Gln Leu Ala Ala 305 310 315 320 Glu Ala Ala Ala Arg
Leu Glu Ala Gln Ala Arg Val His Gln Leu Leu 325 330 335 Leu Gln Asn
Lys Asp Met Leu Gln His Ile Ser Leu Leu Val Lys Gln 340 345 350 Val
Gln Glu Leu Glu Leu Lys Leu Ser Gly Gln Ser Thr Met Gly Ser 355 360
365 Gln Asp Ser Leu Leu Glu Ile Thr Phe Arg Ser Gly Ala Leu Pro Val
370 375 380 Leu Cys Glu Ser Thr Thr Pro Lys Pro Glu Asp Leu His Ser
Pro Leu 385 390 395 400 Leu Gly Ala Gly Leu Ala Asp Phe Ala His Pro
Val Gly Ser Pro Leu 405 410 415 Gly Arg Arg Asp Cys Leu Val Lys Leu
Glu Cys Phe Arg Phe Leu Pro 420 425 430 Ala Glu Asp Asn Gln Pro Met
Ala Gln Gly Glu Pro Leu Leu Gly Gly 435 440 445 Leu Glu Leu Ile Lys
Phe Arg Glu Ser Gly Ile Ala Ser Glu Tyr Glu 450 455 460 Ser Asn Thr
Asp Glu Ser Glu Glu Arg Asp Ser Trp Ser Gln Glu Glu 465 470 475 480
Leu Pro Arg Leu Leu Asn Val Leu Gln Arg Gln Glu Leu Gly Asp Ser 485
490 495 Leu Asp Asp Glu Ile Ala Val 500 62 503 PRT Artificial
Sequence Description of Artificial Sequence Synthetic Sequence 62
Met Ala Ser Lys Thr Lys Tyr Asn Leu Val Asp Glu Gly His Asp Leu 1 5
10 15 Arg Ile Pro Leu His Phe Glu Asp Ala Phe Gln His Gly Ile Ser
Gly 20 25 30 Glu Ala Lys Tyr Val Gly Ser Leu Asp His Pro Arg Pro
Asn Ser Arg 35 40 45 Val Glu Ile Ile Ala Ala Met Arg Arg Ile Arg
Tyr Glu Lys Lys Ala 50 55 60 Lys Asn Ile Lys Lys Lys Lys Leu Ser
Ile Met Val Ser Val Asp Gly 65 70 75 80 Val Met Val Ile Leu Lys Lys
Lys Lys Lys Lys Asn Glu Trp Thr Trp 85 90 95 Asp Glu Ser Lys Met
Gln Val Met Gln Asp Pro Ile Tyr Arg Ile Arg 100 105 110 Tyr Val Ser
His Asp Ser Gln Asp Leu Ser Ile Phe Ser Tyr Ile Ala 115 120 125 Arg
Asp Gly Thr Ser Asn Ile Phe Arg Cys Asn Val Phe Val Ser Lys 130 135
140 Lys Lys Ser Gln Ala Met Arg Trp Val Arg Thr Val Gly Gln Ala Phe
145 150 155 160 Glu Tyr Cys His Lys Leu Ser Leu Gln His Thr Ala Gln
Asn
Ala Asp 165 170 175 Gly Gln Glu Asp Gly Asp Ser Glu Arg Asn Ser Asp
Gly Ser Gly Glu 180 185 190 Pro Gly Arg Gln Leu Thr Gly Ala Glu Phe
Val Ser Thr Ala Thr Ala 195 200 205 Glu Glu Thr Gly Ile Asp Ala Val
Glu Val Pro Leu Pro His Asn Asp 210 215 220 Ile Leu Glu Phe Ser Arg
Gly Ile Thr Asp Leu Asp Ala Ile Gly Lys 225 230 235 240 Asp Lys Gly
Ser His Ile Asp Thr Thr Val Ser Leu His Pro Gln Glu 245 250 255 Pro
Met Leu Ala Ala Met Pro Arg Met Leu Leu Pro Ser Ser Ser Asn 260 265
270 Ser Lys Pro Pro Gly Leu Gly Thr Gly Gln Pro Leu Ser Thr His His
275 280 285 Gln Met Gln Arg Leu Gln Gln Leu Leu Gln Gln Gln Gln Ser
Gln Thr 290 295 300 Gln Val Ala Val Ala Gln Val Thr Leu Leu Lys Asp
Gln Leu Ala Ala 305 310 315 320 Glu Val Ala Ala Arg Leu Glu Ala Gln
Ala Arg Trp His Gln Leu Leu 325 330 335 Leu Gln Asn Lys Asp Tyr Leu
Gln His Ile Ser Leu Leu Val Lys Ala 340 345 350 Val Gln Glu Leu Glu
Leu Lys Leu Ser Asp Gln Ser Thr Met Gly Ser 355 360 365 Gln Asp Ser
Glu Leu Glu Ile Thr Phe Arg Ser Gly Ala Phe Pro Val 370 375 380 Leu
Cys Glu Ser Thr Thr Pro Gly Pro Glu Asp Leu His Ser Pro Leu 385 390
395 400 Leu His Ala Gly Leu Ala Asp Phe Ala His Pro Ile Gly Ser Pro
Leu 405 410 415 Gly Arg Arg Asp Cys Lys Val Lys Leu Glu Cys Phe Arg
Phe Leu Leu 420 425 430 Ala Glu Asp Asn Gln Pro Met Ala Gln Met Glu
Pro Leu Leu Gly Gly 435 440 445 Leu Glu Leu Asn Lys Phe Arg Glu Ser
Gly Ile Ala Ser Gln Tyr Glu 450 455 460 Ser Asn Thr Asp Glu Ser Glu
Arg Arg Asp Ser Trp Ser Gln Glu Glu 465 470 475 480 Leu Ser Arg Leu
Leu Asn Val Leu Gln Arg Gln Thr Leu Gly Asp Ser 485 490 495 Leu Asp
Asp Glu Ile Val Val 500 63 503 PRT Artificial Sequence Description
of Artificial Sequence Synthetic Sequence 63 Met Pro Ala Lys Thr
Lys Tyr Asn Leu Val Asp Asp Asp His Asp Leu 1 5 10 15 Arg Ile Pro
Leu His Asn Phe Asp Ala Phe Gln His Gly Ile Ser Phe 20 25 30 Gly
Ala Lys Tyr Val Gly Ser Leu Asp Val His Arg Pro Asn Ser Arg 35 40
45 Val Glu Ile Val Ile Ala Met Arg Arg Ile Arg Tyr Glu Phe Leu Ala
50 55 60 Lys Asn Ile Lys Lys Lys Lys Val Met Ile Met Val Ser Val
Asp Gly 65 70 75 80 Val Lys Asn Ile Leu Lys Lys Lys Lys Lys Lys Lys
Gln Trp Thr Trp 85 90 95 Asp Glu Ser Lys Met Leu Arg Met Gln Asp
Pro Ile Tyr Arg Ile Phe 100 105 110 Ser Val Ser His Asp Ser Gln Asp
Leu Lys Thr Phe Ser Tyr Ile Ala 115 120 125 Arg Asp Gly Ala Val Asn
Ile Phe Arg Cys Asn Val Phe Lys Trp Lys 130 135 140 Lys Lys Ser Gln
Ala Met Arg Ile Tyr Arg Thr Val Gly Gln Ala Phe 145 150 155 160 Glu
Val Ala His Lys Leu Ser Leu Gln His Thr Gln Asp Asn Ala Asp 165 170
175 Gly Gln Glu Asp Gly Glu Glu Glu Arg Asn Ser Asp Gly Ser Gly Asp
180 185 190 Phe Gly Arg Gln Leu Thr Gly Ala Glu Arg Gly Ser Thr Ala
Thr Ala 195 200 205 Glu Glu Thr Asp His Asp Ala Val Glu Val Pro Leu
Pro Gly Ile Asp 210 215 220 Ile Leu Glu Phe Ser Arg Gly Val Lys Asp
Leu Asp Ala Ile Gly Lys 225 230 235 240 Asp Gly Leu Ser His Ile Asp
Thr Thr Val Ser Pro Met Pro Gln Glu 245 250 255 Pro Met Leu Ala Ala
Ser Asn Arg Met Leu Leu Pro Ser Ser Ser Ser 260 265 270 Gln Lys Pro
Pro Gly Leu Gly Thr Gly Thr Arg Leu Ser Thr His His 275 280 285 Gln
Met Gln Leu Ser Gln Gln Leu Leu Gln Gln Gln Gln Gln Thr Thr 290 295
300 Gln Val Ala Val Ala Gln Val His Val Leu Lys Asp Gln Leu Ala Ala
305 310 315 320 Glu Ala Trp Ala Arg Leu Glu Ala Gln Ala Arg Val Tyr
Gln Leu Leu 325 330 335 Leu Gln Asn Lys Asp Met Ala Gln His Ile Ser
Leu Leu Val Lys Gln 340 345 350 Asp Gln Glu Leu Glu Leu Lys Leu Ser
Gly Glu Ser Thr Met Gly Ser 355 360 365 Gln Asp Ser Leu Phe Glu Ile
Thr Phe Arg Ser Gly Ala Leu Gly Val 370 375 380 Leu Cys Glu Ser Thr
Thr Pro Lys His Glu Asp Leu His Ser Pro Leu 385 390 395 400 Leu Gly
Ile Gly Leu Ala Asp Phe Ala His Pro Val Lys Ser Pro Leu 405 410 415
Gly Arg Arg Asp Cys Leu Leu Lys Leu Glu Cys Phe Arg Phe Leu Pro 420
425 430 Met Glu Asp Asn Gln Pro Met Ala Gln Gly Asn Pro Leu Leu Gly
Gly 435 440 445 Leu Glu Leu Ile Gln Phe Arg Glu Ser Gly Ile Ala Ser
Glu Arg Glu 450 455 460 Ser Asn Thr Asp Glu Ser Glu Glu Ser Asp Ser
Trp Ser Gln Glu Glu 465 470 475 480 Leu Pro Thr Leu Leu Asn Val Leu
Gln Arg Gln Glu Val Gly Asp Ser 485 490 495 Leu Asp Asp Glu Ile Ala
Trp 500 64 503 PRT Artificial Sequence Description of Artificial
Sequence Synthetic Sequence 64 Met Pro Ser Ala Thr Lys Tyr Asn Leu
Val Asp Asp Gly Asp Asp Leu 1 5 10 15 Arg Ile Pro Leu His Asn Glu
Glu Ala Phe Gln His Gly Ile Ser Phe 20 25 30 Glu Phe Lys Tyr Val
Gly Ser Leu Asp Val Pro Gly Pro Asn Ser Arg 35 40 45 Val Glu Ile
Val Ala His Met Arg Arg Ile Arg Tyr Glu Phe Lys Ile 50 55 60 Lys
Asn Ile Lys Lys Lys Lys Val Ser Lys Met Val Ser Val Asp Gly 65 70
75 80 Val Lys Val Leu Leu Lys Lys Lys Lys Lys Lys Lys Glu Met Thr
Trp 85 90 95 Asp Glu Ser Lys Met Leu Val Asn Gln Asp Pro Ile Tyr
Arg Ile Phe 100 105 110 Tyr Gln Ser His Asp Ser Gln Asp Leu Lys Ile
Arg Ser Tyr Ile Ala 115 120 125 Arg Asp Gly Ala Ser Ser Ile Phe Arg
Cys Asn Val Phe Lys Ser Thr 130 135 140 Lys Lys Ser Gln Ala Met Arg
Ile Val Val Thr Val Gly Gln Ala Phe 145 150 155 160 Glu Val Cys Trp
Lys Leu Ser Leu Gln His Thr Gln Gln Tyr Ala Asp 165 170 175 Gly Gln
Glu Asp Gly Glu Ser Ala Arg Asn Ser Asp Gly Ser Gly Asp 180 185 190
Pro Asp Arg Gln Leu Thr Gly Ala Glu Arg Val Glu Thr Ala Thr Ala 195
200 205 Glu Glu Thr Asp Ile Phe Ala Val Glu Val Pro Leu Pro Gly Asn
Gly 210 215 220 Ile Leu Glu Phe Ser Arg Gly Val Thr His Leu Asp Ala
Ile Gly Lys 225 230 235 240 Asp Gly Gly Ile His Ile Asp Thr Thr Val
Ser Pro His Lys Gln Glu 245 250 255 Pro Met Leu Ala Ala Ser Pro Leu
Met Leu Leu Pro Ser Ser Ser Ser 260 265 270 Ser Met Pro Pro Gly Leu
Gly Thr Gly Thr Pro Asn Ser Thr His His 275 280 285 Gln Met Gln Leu
Leu Arg Gln Leu Leu Gln Gln Gln Gln Gln Gln Ser 290 295 300 Gln Val
Ala Val Ala Gln Val His Leu Thr Lys Asp Gln Leu Ala Ala 305 310 315
320 Glu Ala Ala Val Arg Leu Glu Ala Gln Ala Arg Val His Trp Leu Leu
325 330 335 Leu Gln Asn Lys Asp Met Leu Tyr His Ile Ser Leu Leu Val
Lys Gln 340 345 350 Val Ala Glu Leu Glu Leu Lys Leu Ser Gly Gln Asp
Thr Met Gly Ser 355 360 365 Gln Asp Ser Leu Leu Phe Ile Thr Phe Arg
Ser Gly Ala Leu Pro Gly 370 375 380 Leu Cys Glu Ser Thr Thr Pro Lys
Pro His Asp Leu His Ser Pro Leu 385 390 395 400 Leu Gly Ala Ile Leu
Ala Asp Phe Ala His Pro Val Gly Lys Pro Leu 405 410 415 Gly Arg Arg
Asp Cys Leu Val Leu Leu Glu Cys Phe Arg Phe Leu Pro 420 425 430 Ala
Met Asp Asn Gln Pro Met Ala Gln Gly Glu Asn Leu Leu Gly Gly 435 440
445 Leu Glu Leu Ile Lys Gln Arg Glu Ser Gly Ile Ala Ser Glu Tyr Arg
450 455 460 Ser Asn Thr Asp Glu Ser Glu Glu Arg Ser Ser Trp Ser Gln
Glu Glu 465 470 475 480 Leu Pro Arg Thr Leu Asn Val Leu Gln Arg Gln
Glu Leu Val Asp Ser 485 490 495 Leu Asp Asp Glu Ile Ala Val 500 65
503 PRT Artificial Sequence Description of Artificial Sequence
Synthetic Sequence 65 Met Pro Ser Lys Ala Lys Tyr Asn Leu Val Asp
Asp Gly His Glu Leu 1 5 10 15 Arg Ile Pro Leu His Asn Glu Asp Phe
Phe Gln His Gly Ile Ser Phe 20 25 30 Glu Ala Gly Tyr Val Gly Ser
Leu Asp Val Pro Arg His Asn Ser Arg 35 40 45 Val Glu Ile Val Ala
Ala Ile Arg Arg Ile Arg Tyr Glu Phe Lys Ala 50 55 60 Leu Asn Ile
Lys Lys Lys Lys Val Ser Ile Asn Val Ser Val Asp Gly 65 70 75 80 Val
Lys Val Ile Gln Lys Lys Lys Lys Lys Lys Lys Glu Trp Arg Trp 85 90
95 Asp Glu Ser Lys Met Leu Val Met Ser Asp Pro Ile Tyr Arg Ile Phe
100 105 110 Tyr Val Thr His Asp Ser Gln Asp Leu Lys Ile Phe Val Tyr
Ile Ala 115 120 125 Arg Asp Gly Ala Ser Asn Trp Phe Arg Cys Asn Val
Phe Lys Ser Lys 130 135 140 Tyr Lys Ser Gln Ala Met Arg Ile Val Arg
Ala Val Gly Gln Ala Phe 145 150 155 160 Glu Val Cys His Asp Leu Ser
Leu Gln His Thr Gln Gln Asn Glu Asp 165 170 175 Gly Gln Glu Asp Gly
Glu Ser Glu Phe Asn Ser Asp Gly Ser Gly Asp 180 185 190 Pro Gly Gly
Gln Leu Thr Gly Ala Glu Arg Val Ser His Ala Thr Ala 195 200 205 Glu
Glu Thr Asp Ile Asp Ile Val Glu Val Pro Leu Pro Gly Asn Asp 210 215
220 Lys Leu Glu Phe Ser Arg Gly Val Thr Asp Met Asp Ala Ile Gly Lys
225 230 235 240 Asp Gly Gly Ser Asn Ile Asp Thr Thr Val Ser Pro His
Pro Arg Glu 245 250 255 Pro Met Leu Ala Ala Ser Pro Arg Ser Leu Leu
Pro Ser Ser Ser Ser 260 265 270 Ser Lys Thr Pro Gly Leu Gly Thr Gly
Thr Pro Leu Val Thr His His 275 280 285 Gln Met Gln Leu Leu Gln Trp
Leu Leu Gln Gln Gln Gln Gln Gln Thr 290 295 300 Tyr Val Ala Val Ala
Gln Val His Leu Leu Ala Asp Gln Leu Ala Ala 305 310 315 320 Glu Ala
Ala Ala Asp Leu Glu Ala Gln Ala Arg Val His Gln Glu Leu 325 330 335
Leu Gln Asn Lys Asp Met Leu Gln Phe Ile Ser Leu Leu Val Lys Gln 340
345 350 Val Gln Gly Leu Glu Leu Lys Leu Ser Gly Gln Ser His Met Gly
Ser 355 360 365 Gln Asp Ser Leu Leu Glu Lys Thr Phe Arg Ser Gly Ala
Leu Pro Val 370 375 380 Met Cys Glu Ser Thr Thr Pro Lys Pro Glu Asn
Leu His Ser Pro Leu 385 390 395 400 Leu Gly Ala Gly Gln Ala Asp Phe
Ala His Pro Val Gly Ser Arg Leu 405 410 415 Gly Arg Arg Asp Cys Leu
Val Lys Ser Glu Cys Phe Arg Phe Leu Pro 420 425 430 Ala Glu Thr Asn
Gln Pro Met Ala Gln Gly Glu Pro Val Leu Gly Gly 435 440 445 Leu Glu
Leu Ile Lys Phe Trp Glu Ser Gly Ile Ala Ser Glu Tyr Glu 450 455 460
Tyr Asn Thr Asp Glu Ser Glu Glu Arg Asp Ala Trp Ser Gln Glu Glu 465
470 475 480 Leu Pro Arg Leu Asp Asn Val Leu Gln Arg Gln Glu Leu Gly
Glu Ser 485 490 495 Leu Asp Asp Glu Ile Ala Val 500 66 503 PRT
Artificial Sequence Description of Artificial Sequence Synthetic
Sequence 66 Met Pro Ser Lys Thr Ala Tyr Asn Leu Val Asp Asp Gly His
Asp Asp 1 5 10 15 Arg Ile Pro Leu His Asn Glu Asp Ala Glu Gln His
Gly Ile Ser Phe 20 25 30 Glu Ala Lys Phe Val Gly Ser Leu Asp Val
Pro Arg Pro Gly Ser Arg 35 40 45 Val Glu Ile Val Ala Ala Met His
Arg Ile Arg Tyr Glu Phe Lys Ala 50 55 60 Lys Ile Ile Lys Lys Lys
Lys Val Ser Ile Met Lys Ser Val Asp Gly 65 70 75 80 Val Lys Val Ile
Leu Leu Lys Lys Lys Lys Lys Lys Glu Trp Thr Met 85 90 95 Asp Glu
Ser Lys Met Leu Val Met Gln Asn Pro Ile Tyr Arg Ile Phe 100 105 110
Tyr Val Ser Gln Asp Ser Gln Asp Leu Lys Ile Phe Ser Arg Ile Ala 115
120 125 Arg Asp Gly Ala Ser Asn Ile Ser Arg Cys Asn Val Phe Lys Ser
Lys 130 135 140 Lys Thr Ser Gln Ala Met Arg Ile Val Arg Thr Trp Gly
Gln Ala Phe 145 150 155 160 Glu Val Cys His Lys Tyr Ser Leu Gln His
Thr Gln Gln Asn Ala Ala 165 170 175 Gly Gln Glu Asp Gly Glu Ser Glu
Arg Asp Ser Asp Gly Ser Gly Asp 180 185 190 Pro Gly Arg Glu Leu Thr
Gly Ala Glu Arg Val Ser Thr Phe Thr Ala 195 200 205 Glu Glu Thr Asp
Ile Asp Ala Gly Glu Val Pro Leu Pro Gly Asn Asp 210 215 220 Ile His
Glu Phe Ser Arg Gly Val Thr Asp Leu Ile Ala Ile Gly Lys 225 230 235
240 Asp Gly Gly Ser His Lys Asp Thr Thr Val Ser Pro His Pro Gln Leu
245 250 255 Pro Met Leu Ala Ala Ser Pro Arg Met Met Leu Pro Ser Ser
Ser Ser 260 265 270 Ser Lys Pro Asn Gly Leu Gly Thr Gly Thr Pro Leu
Ser Gln His His 275 280 285 Gln Met Gln Leu Leu Gln Gln Arg Leu Gln
Gln Gln Gln Gln Gln Thr 290 295 300 Gln Ser Ala Val Ala Gln Val His
Leu Leu Lys Thr Gln Leu Ala Ala 305 310 315 320 Glu Ala Ala Ala Arg
Val Glu Ala Gln Ala Arg Val His Gln Leu Trp 325 330 335 Leu Gln Asn
Lys Asp Met Leu Gln His Tyr Ser Leu Leu Val Lys Gln 340 345 350 Val
Gln Glu Ala Glu Leu Lys Leu Ser Gly Gln Ser Thr Asp Gly Ser 355 360
365 Gln Asp Ser Leu Leu Glu Ile Glu Phe Arg Ser Gly Ala Leu Pro Val
370 375 380 Leu Phe Glu Ser Thr Thr Pro Lys Pro Glu Asp Gly His Ser
Pro Leu 385 390 395 400 Leu Gly Ala Gly Leu His Asp Phe Ala His Pro
Val Gly Ser Pro Ile 405 410 415 Gly Arg Arg Asp Cys Leu Val Lys Leu
Lys Cys Phe Arg Phe Leu Pro 420 425 430 Ala Glu Asp Leu Gln Pro Met
Ala Gln Gly Glu Pro Leu Met Gly Gly 435 440 445 Leu Glu Leu Ile Lys
Phe Arg Asn Ser Gly Ile Ala Ser Glu Tyr Glu 450 455 460 Ser Gln Thr
Asp Glu Ser Glu Glu Arg Asp Ser Arg Ser Gln Glu Glu 465 470 475 480
Leu Pro Arg Leu Leu Ser Val Leu Gln Arg Gln Glu Leu Gly Asp Thr 485
490 495 Leu Asp Asp Glu Ile Ala Val 500 67 503 PRT Artificial
Sequence Description of Artificial Sequence Synthetic Sequence 67
Met Pro Ser Lys Thr Lys Ala Asn Leu Val Asp Asp Gly His Asp Leu 1 5
10 15 Asp Ile Pro Leu His Asn Glu Asp Ala Phe Glu His Gly Ile Ser
Phe 20 25 30 Glu Ala Lys Tyr Phe Gly Ser Leu Asp Val Pro Arg Pro
Asn Gly
Arg 35 40 45 Val Glu Ile Val Ala Ala Met Arg His Ile Arg Tyr Glu
Phe Lys Ala 50 55 60 Lys Asn Lys Lys Lys Lys Lys Val Ser Ile Met
Val Leu Val Asp Gly 65 70 75 80 Val Lys Val Ile Leu Lys Met Lys Lys
Lys Lys Lys Glu Trp Thr Trp 85 90 95 Asn Glu Ser Lys Met Leu Val
Met Gln Asp Gln Ile Tyr Arg Ile Phe 100 105 110 Tyr Val Ser His Arg
Ser Gln Asp Leu Lys Ile Phe Ser Tyr Ser Ala 115 120 125 Arg Asp Gly
Ala Ser Asn Ile Phe Thr Cys Asn Val Phe Lys Ser Lys 130 135 140 Lys
Lys Val Gln Ala Met Arg Ile Val Arg Thr Val Trp Gln Ala Phe 145 150
155 160 Glu Val Cys His Lys Leu Tyr Leu Gln His Thr Gln Gln Asn Ala
Asp 165 170 175 Ala Gln Glu Asp Gly Glu Ser Glu Arg Asn Asp Asp Gly
Ser Gly Asp 180 185 190 Pro Gly Arg Gln Glu Thr Gly Ala Glu Arg Val
Ser Thr Ala Phe Ala 195 200 205 Glu Glu Thr Asp Ile Asp Ala Val Gly
Val Pro Leu Pro Gly Asn Asp 210 215 220 Ile Leu His Phe Ser Arg Gly
Val Thr Asp Leu Asp Ile Ile Gly Lys 225 230 235 240 Asp Gly Gly Ser
His Ile Lys Thr Thr Val Ser Pro His Pro Gln Glu 245 250 255 Leu Met
Leu Ala Ala Ser Pro Arg Met Leu Met Pro Ser Ser Ser Ser 260 265 270
Ser Lys Pro Pro Asn Leu Gly Thr Gly Thr Pro Leu Ser Thr Gln His 275
280 285 Gln Met Gln Leu Leu Gln Gln Leu Arg Gln Gln Gln Gln Gln Gln
Thr 290 295 300 Gln Val Ser Val Ala Gln Val His Leu Leu Lys Asp Thr
Leu Ala Ala 305 310 315 320 Glu Ala Ala Ala Arg Leu Val Ala Gln Ala
Arg Val His Gln Leu Leu 325 330 335 Trp Gln Asn Lys Asp Met Leu Gln
His Ile Tyr Leu Leu Val Lys Gln 340 345 350 Val Gln Glu Leu Ala Leu
Lys Leu Ser Gly Gln Ser Thr Met Asp Ser 355 360 365 Gln Asp Ser Leu
Leu Glu Ile Thr Glu Arg Ser Gly Ala Leu Pro Val 370 375 380 Leu Cys
Phe Ser Thr Thr Pro Lys Pro Glu Asp Leu Gly Ser Pro Leu 385 390 395
400 Leu Gly Ala Gly Leu Ala His Phe Ala His Pro Val Gly Ser Pro Leu
405 410 415 Ile Arg Arg Asp Cys Leu Val Lys Leu Glu Lys Phe Arg Phe
Leu Pro 420 425 430 Ala Glu Asp Asn Leu Pro Met Ala Gln Gly Glu Pro
Leu Leu Met Gly 435 440 445 Leu Glu Leu Ile Lys Phe Arg Glu Asn Gly
Ile Ala Ser Glu Tyr Glu 450 455 460 Ser Asn Gln Asp Glu Ser Glu Glu
Arg Asp Ser Trp Arg Gln Glu Glu 465 470 475 480 Leu Pro Arg Leu Leu
Asn Ser Leu Gln Arg Gln Glu Leu Gly Asp Ser 485 490 495 Thr Asp Asp
Glu Ile Ala Val 500 68 503 PRT Artificial Sequence Description of
Artificial Sequence Synthetic Sequence 68 Met Pro Ser Lys Thr Lys
Tyr Ala Leu Val Asp Asp Gly His Asp Leu 1 5 10 15 Arg Asp Pro Leu
His Asn Glu Asp Ala Phe Gln His Gly Ile Ser Phe 20 25 30 Glu Ala
Lys Tyr Val Glu Ser Leu Asp Val Pro Arg Pro Asn Ser Phe 35 40 45
Val Glu Ile Val Ala Ala Met Arg Arg Gly Arg Tyr Glu Phe Lys Ala 50
55 60 Lys Asn Ile His Lys Lys Lys Val Ser Ile Met Val Ser Ile Asp
Gly 65 70 75 80 Val Lys Val Ile Leu Lys Lys Leu Lys Lys Lys Lys Glu
Trp Thr Trp 85 90 95 Asp Met Ser Lys Met Leu Val Met Gln Asp Pro
Asn Tyr Arg Ile Phe 100 105 110 Tyr Val Ser His Asp Gln Gln Asp Leu
Lys Ile Phe Ser Tyr Ile Arg 115 120 125 Arg Asp Gly Ala Ser Asn Ile
Phe Arg Ser Asn Val Phe Lys Ser Lys 130 135 140 Lys Lys Ser Thr Ala
Met Arg Ile Val Arg Thr Val Gly Val Ala Phe 145 150 155 160 Glu Val
Cys His Lys Leu Ser Trp Gln His Thr Gln Gln Asn Ala Asp 165 170 175
Gly Tyr Glu Asp Gly Glu Ser Glu Arg Asn Ser Ala Gly Ser Gly Asp 180
185 190 Pro Gly Arg Gln Leu Asp Gly Ala Glu Arg Val Ser Thr Ala Thr
Glu 195 200 205 Glu Glu Thr Asp Ile Asp Ala Val Glu Phe Pro Leu Pro
Gly Asn Asp 210 215 220 Ile Leu Glu Gly Ser Arg Gly Val Thr Asp Leu
Asp Ala His Gly Lys 225 230 235 240 Asp Gly Gly Ser His Ile Asp Ile
Thr Val Ser Pro His Pro Gln Glu 245 250 255 Pro Lys Leu Ala Ala Ser
Pro Arg Met Leu Leu Leu Ser Ser Ser Ser 260 265 270 Ser Lys Pro Pro
Gly Met Gly Thr Gly Thr Pro Leu Ser Thr His Asn 275 280 285 Gln Met
Gln Leu Leu Gln Gln Leu Leu Arg Gln Gln Gln Gln Gln Thr 290 295 300
Gln Val Ala Ser Ala Gln Val His Leu Leu Lys Asp Gln Thr Ala Ala 305
310 315 320 Glu Ala Ala Ala Arg Leu Glu Val Gln Ala Arg Val His Gln
Leu Leu 325 330 335 Leu Trp Asn Lys Asp Met Leu Gln His Ile Ser Tyr
Leu Val Lys Gln 340 345 350 Val Gln Glu Leu Glu Ala Lys Leu Ser Gly
Gln Ser Thr Met Gly Asp 355 360 365 Gln Asp Ser Leu Leu Glu Ile Thr
Phe Glu Ser Gly Ala Leu Pro Val 370 375 380 Leu Cys Glu Phe Thr Thr
Pro Lys Pro Glu Asp Leu His Gly Pro Leu 385 390 395 400 Leu Gly Ala
Gly Leu Ala Asp His Ala His Pro Val Gly Ser Pro Leu 405 410 415 Gly
Ile Arg Asp Cys Leu Val Lys Leu Glu Cys Lys Arg Phe Leu Pro 420 425
430 Ala Glu Asp Asn Gln Leu Met Ala Gln Gly Glu Pro Leu Leu Gly Met
435 440 445 Leu Glu Leu Ile Lys Phe Arg Glu Ser Asn Ile Ala Ser Glu
Tyr Glu 450 455 460 Ser Asn Thr Gln Glu Ser Glu Glu Arg Asp Ser Trp
Ser Arg Glu Glu 465 470 475 480 Leu Pro Arg Leu Leu Asn Val Ser Gln
Arg Gln Glu Leu Gly Asp Ser 485 490 495 Leu Thr Asp Glu Ile Ala Val
500 69 503 PRT Artificial Sequence Description of Artificial
Sequence Synthetic Sequence 69 Met Pro Ser Lys Thr Lys Tyr Asn Ala
Val Asp Asp Gly His Asp Leu 1 5 10 15 Arg Ile Asp Leu His Asn Glu
Asp Ala Phe Gln His Glu Ile Ser Phe 20 25 30 Glu Ala Lys Tyr Val
Gly Phe Leu Asp Val Pro Arg Pro Asn Ser Arg 35 40 45 Gly Glu Ile
Val Ala Ala Met Arg Arg Ile His Tyr Glu Phe Lys Ala 50 55 60 Lys
Asn Ile Lys Ile Lys Lys Val Ser Ile Met Val Ser Val Lys Gly 65 70
75 80 Val Lys Val Ile Leu Lys Lys Lys Leu Lys Lys Lys Glu Trp Thr
Trp 85 90 95 Asp Glu Met Lys Met Leu Val Met Gln Asp Pro Ile Asn
Arg Ile Phe 100 105 110 Tyr Val Ser His Asp Ser Gln Asp Leu Lys Ile
Phe Ser Tyr Ile Ala 115 120 125 Ser Asp Gly Ala Ser Asn Ile Phe Arg
Cys Thr Val Phe Lys Ser Lys 130 135 140 Lys Lys Ser Gln Val Met Arg
Ile Val Arg Thr Val Gly Gln Trp Phe 145 150 155 160 Glu Val Cys His
Lys Leu Ser Leu Tyr His Thr Gln Gln Asn Ala Asp 165 170 175 Gly Gln
Ala Asp Gly Glu Ser Glu Arg Asn Ser Asp Asp Ser Gly Asp 180 185 190
Pro Gly Arg Gln Leu Thr Glu Ala Glu Arg Val Ser Thr Ala Thr Ala 195
200 205 Phe Glu Thr Asp Ile Asp Ala Val Glu Val Gly Leu Pro Gly Asn
Asp 210 215 220 Ile Leu Glu Phe His Arg Gly Val Thr Asp Leu Asp Ala
Ile Ile Lys 225 230 235 240 Asp Gly Gly Ser His Ile Asp Thr Lys Val
Ser Pro His Pro Gln Glu 245 250 255 Pro Met Met Ala Ala Ser Pro Arg
Met Leu Leu Pro Asn Ser Ser Ser 260 265 270 Ser Lys Pro Pro Gly Leu
Gln Thr Gly Thr Pro Leu Ser Thr His His 275 280 285 Arg Met Gln Leu
Leu Gln Gln Leu Leu Gln Ser Gln Gln Gln Gln Thr 290 295 300 Gln Val
Ala Val Thr Gln Val His Leu Leu Lys Asp Gln Leu Val Ala 305 310 315
320 Glu Ala Ala Ala Arg Leu Glu Ala Trp Ala Arg Val His Gln Leu Leu
325 330 335 Leu Gln Tyr Lys Asp Met Leu Gln His Ile Ser Leu Ala Val
Lys Gln 340 345 350 Val Gln Glu Leu Glu Leu Asp Leu Ser Gly Gln Ser
Thr Met Gly Ser 355 360 365 Glu Asp Ser Leu Leu Glu Ile Thr Phe Arg
Phe Gly Ala Leu Pro Val 370 375 380 Leu Cys Glu Ser Gly Thr Pro Lys
Pro Glu Asp Leu His Ser His Leu 385 390 395 400 Leu Gly Ala Gly Leu
Ala Asp Phe Ile His Pro Val Gly Ser Pro Leu 405 410 415 Gly Arg Lys
Asp Cys Leu Val Lys Leu Glu Cys Phe Leu Phe Leu Pro 420 425 430 Ala
Glu Asp Asn Gln Pro Asn Ala Gln Gly Glu Pro Leu Leu Gly Gly 435 440
445 Gln Glu Leu Ile Lys Phe Arg Glu Ser Gly Arg Ala Ser Glu Tyr Glu
450 455 460 Ser Asn Thr Asp Ser Ser Glu Glu Arg Asp Ser Trp Ser Gln
Thr Glu 465 470 475 480 Leu Pro Arg Leu Leu Asn Val Leu Val Arg Gln
Glu Leu Gly Asp Ser 485 490 495 Leu Asp Trp Glu Ile Ala Val 500 70
503 PRT Artificial Sequence Description of Artificial Sequence
Synthetic Sequence 70 Met Pro Ser Lys Thr Lys Tyr Asn Leu Ala Asp
Asp Gly His Asp Leu 1 5 10 15 Arg Ile Pro Asp His Asn Glu Asp Ala
Phe Gln His Gly Glu Ser Phe 20 25 30 Glu Ala Lys Tyr Val Gly Ser
Phe Asp Val Pro Arg Pro Asn Ser Arg 35 40 45 Val Gly Ile Val Ala
Ala Met Arg Arg Ile Arg His Glu Phe Lys Ala 50 55 60 Lys Asn Ile
Lys Lys Ile Lys Val Ser Ile Met Val Ser Val Asp Lys 65 70 75 80 Val
Lys Val Ile Leu Lys Lys Lys Lys Leu Lys Lys Glu Trp Thr Trp 85 90
95 Asp Glu Ser Met Met Leu Val Met Gln Asp Pro Ile Tyr Asn Ile Phe
100 105 110 Tyr Val Ser His Asp Ser Gln Gln Leu Lys Ile Phe Ser Tyr
Ile Ala 115 120 125 Arg Arg Gly Ala Ser Asn Ile Phe Arg Cys Asn Ser
Phe Lys Ser Lys 130 135 140 Lys Lys Ser Gln Ala Thr Arg Ile Val Arg
Thr Val Gly Gln Ala Val 145 150 155 160 Glu Val Cys His Lys Leu Ser
Leu Gln Trp Thr Gln Gln Asn Ala Asp 165 170 175 Gly Gln Glu Tyr Gly
Glu Ser Glu Arg Asn Ser Asp Gly Ala Gly Asp 180 185 190 Pro Gly Arg
Gln Leu Thr Gly Asp Glu Arg Val Ser Thr Ala Thr Ala 195 200 205 Glu
Phe Thr Asp Ile Asp Ala Val Glu Val Pro Gly Pro Gly Asn Asp 210 215
220 Ile Leu Glu Phe Ser His Gly Val Thr Asp Leu Asp Ala Ile Gly Ile
225 230 235 240 Asp Gly Gly Ser His Ile Asp Thr Thr Lys Ser Pro His
Pro Gln Glu 245 250 255 Pro Met Leu Leu Ala Ser Pro Arg Met Leu Leu
Pro Ser Met Ser Ser 260 265 270 Ser Lys Pro Pro Gly Leu Gly Asn Gly
Thr Pro Leu Ser Thr His His 275 280 285 Gln Gln Gln Leu Leu Gln Gln
Leu Leu Gln Gln Arg Gln Gln Gln Thr 290 295 300 Gln Val Ala Val Ala
Ser Val His Leu Leu Lys Asp Gln Leu Ala Thr 305 310 315 320 Glu Ala
Ala Ala Arg Leu Glu Ala Gln Val Arg Val His Gln Leu Leu 325 330 335
Leu Gln Asn Trp Asp Met Leu Gln His Ile Ser Leu Leu Tyr Lys Gln 340
345 350 Val Gln Glu Leu Glu Leu Lys Ala Ser Gly Gln Ser Thr Met Gly
Ser 355 360 365 Gln Glu Ser Leu Leu Glu Ile Thr Phe Arg Ser Phe Ala
Leu Pro Val 370 375 380 Leu Cys Glu Ser Thr Gly Pro Lys Pro Glu Asp
Leu His Ser Pro His 385 390 395 400 Leu Gly Ala Gly Leu Ala Asp Phe
Ala Ile Pro Val Gly Ser Pro Leu 405 410 415 Gly Arg Arg Lys Cys Leu
Val Lys Leu Glu Cys Phe Arg Leu Leu Pro 420 425 430 Ala Glu Asp Asn
Gln Pro Met Met Gln Gly Glu Pro Leu Leu Gly Gly 435 440 445 Leu Asn
Leu Ile Lys Phe Arg Glu Ser Gly Ile Gln Ser Glu Tyr Glu 450 455 460
Ser Asn Thr Asp Glu Arg Glu Glu Arg Asp Ser Trp Ser Gln Glu Ser 465
470 475 480 Leu Pro Arg Leu Leu Asn Val Leu Gln Thr Gln Glu Leu Gly
Asp Ser 485 490 495 Leu Asp Asp Val Ile Ala Val 500 71 163 PRT
Artificial Sequence Description of Artificial Sequence Synthetic
Sequence 71 Glu Phe Ala Ala Ala Ser Thr Gln Pro Ala Glu Leu Ala Ser
Leu Gly 1 5 10 15 Glu Ser Gln Ser Arg Glu Ser Leu Ser Phe Thr Ser
Pro Ser Thr Ser 20 25 30 Ser Glu Val Tyr Lys Ile Lys Phe Ile Phe
Pro Asn Gly Asp Thr Tyr 35 40 45 Asp Gly Asp Cys Thr Arg Thr Thr
Ser Gly Ile Cys Glu Arg Asn Gly 50 55 60 Thr Gly Thr His Thr Thr
Pro Asn Gly Ile Val Tyr Thr Gly Ser Trp 65 70 75 80 Lys Asp Asp Lys
Met Asn Gly Phe Gly Arg Leu Glu His Phe Ser Gly 85 90 95 Ala Val
Tyr Glu Gly Gln Phe Lys Asp Asn Met Phe His Gly Leu Gly 100 105 110
Thr Tyr Thr Phe Pro Thr Gly Ala Lys Tyr Thr Gly Asn Phe Asn Glu 115
120 125 Asn Arg Val Glu Gly Glu Gly Glu Tyr Thr Asp Thr Gln Gly Leu
Gln 130 135 140 Trp Cys Gly Asn Phe His Phe Thr Ala Ala Pro Gly Leu
Lys Leu Lys 145 150 155 160 Leu Tyr Met 72 163 PRT Artificial
Sequence Description of Artificial Sequence Synthetic Sequence 72
Glu Ala Ala Ala Ala Ser Thr Gln Pro Ala Glu Asp Ala Ser Leu Gly 1 5
10 15 Glu Ser Gln Ser Arg Phe Ser Leu Ser Phe Thr Ser Pro Ser Thr
Gly 20 25 30 Ser Glu Val Tyr Lys Ile Lys Phe Ile His Pro Asn Gly
Asp Thr Tyr 35 40 45 Asp Gly Asp Ile Thr Arg Thr Thr Ser Gly Ile
Cys Glu Lys Asn Gly 50 55 60 Thr Gly Thr His Thr Thr Pro Leu Gly
Ile Val Tyr Thr Gly Ser Trp 65 70 75 80 Lys Met Asp Lys Met Asn Gly
Phe Gly Arg Leu Asn His Phe Ser Gly 85 90 95 Ala Val Tyr Glu Gly
Arg Phe Lys Asp Asn Met Phe His Gly Leu Ser 100 105 110 Thr Tyr Thr
Phe Pro Thr Gly Ala Lys Thr Thr Gly Asn Phe Asn Glu 115 120 125 Asn
Arg Val Val Gly Glu Gly Glu Tyr Thr Asp Thr Gln Trp Leu Gln 130 135
140 Trp Cys Gly Asn Phe His Phe Tyr Ala Ala Pro Gly Leu Lys Leu Lys
145 150 155 160 Leu Ala Met 73 163 PRT Artificial Sequence
Description of Artificial Sequence Synthetic Sequence 73 Glu Phe
Asp Ala Ala Ser Thr Gln Pro Ala Glu Leu Glu Ser Leu Gly 1 5 10 15
Glu Ser Gln Ser Arg Glu Phe Leu Ser Phe Thr Ser Pro Ser Thr Ser 20
25 30 Gly Glu Val Tyr Lys Ile Lys Phe Ile Phe His Asn Gly Asp Thr
Tyr 35 40 45 Asp Gly Asp Cys Ile Arg Thr Thr Ser Gly Ile Cys Glu
Arg Lys Gly 50 55 60 Thr Gly Thr His Thr Thr Pro Asn Leu Ile Val
Tyr Thr Gly Ser Trp 65 70 75
80 Lys Asp Met Lys Met Asn Gly Phe Gly Arg Leu Glu Asn Phe Ser Gly
85 90 95 Ala Val Tyr Glu Gly Gln Gln Lys Asp Asn Met Phe His Gly
Leu Gly 100 105 110 Arg Tyr Thr Phe Pro Thr Gly Ala Lys Tyr Ser Gly
Asn Phe Asn Glu 115 120 125 Asn Arg Val Glu Thr Glu Gly Glu Tyr Thr
Asp Thr Gln Gly Val Gln 130 135 140 Trp Cys Gly Asn Phe His Phe Thr
Trp Ala Pro Gly Leu Lys Leu Lys 145 150 155 160 Leu Tyr Tyr 74 163
PRT Artificial Sequence Description of Artificial Sequence
Synthetic Sequence 74 Glu Phe Ala Asp Ala Ser Thr Gln Pro Ala Glu
Leu Ala Glu Leu Gly 1 5 10 15 Glu Ser Gln Ser Arg Glu Ser Phe Ser
Phe Thr Ser Pro Ser Thr Ser 20 25 30 Ser Gly Val Tyr Lys Ile Lys
Phe Ile Phe Pro His Gly Asp Thr Tyr 35 40 45 Asp Gly Asp Cys Thr
Ile Thr Thr Ser Gly Ile Cys Glu Arg Asn Lys 50 55 60 Thr Gly Thr
His Thr Thr Pro Asn Gly Leu Val Tyr Thr Gly Ser Trp 65 70 75 80 Lys
Asp Asp Met Met Asn Gly Phe Gly Arg Leu Glu His Asn Ser Gly 85 90
95 Ala Val Tyr Glu Gly Gln Phe Gln Asp Asn Met Phe His Gly Leu Gly
100 105 110 Thr Arg Thr Phe Pro Thr Gly Ala Lys Tyr Thr Ser Asn Phe
Asn Glu 115 120 125 Asn Arg Val Glu Gly Thr Gly Glu Tyr Thr Asp Thr
Gln Gly Leu Val 130 135 140 Trp Cys Gly Asn Phe His Phe Thr Ala Trp
Pro Gly Leu Lys Leu Lys 145 150 155 160 Leu Tyr Met 75 163 PRT
Artificial Sequence Description of Artificial Sequence Synthetic
Sequence 75 Glu Phe Ala Ala Asp Ser Thr Gln Pro Ala Glu Leu Ala Ser
Glu Gly 1 5 10 15 Glu Ser Gln Ser Arg Glu Ser Leu Phe Phe Thr Ser
Pro Ser Thr Ser 20 25 30 Ser Glu Gly Tyr Lys Ile Lys Phe Ile Phe
Pro Asn His Asp Thr Tyr 35 40 45 Asp Gly Asp Cys Thr Arg Ile Thr
Ser Gly Ile Cys Glu Arg Asn Gly 50 55 60 Lys Gly Thr His Thr Thr
Pro Asn Gly Ile Leu Tyr Thr Gly Ser Trp 65 70 75 80 Lys Asp Asp Lys
Asn Asn Gly Phe Gly Arg Leu Glu His Phe Gln Gly 85 90 95 Ala Val
Tyr Glu Gly Gln Phe Lys Arg Asn Met Phe His Gly Leu Gly 100 105 110
Thr Tyr Ser Phe Pro Thr Gly Ala Lys Tyr Thr Gly Thr Phe Asn Glu 115
120 125 Asn Arg Val Glu Gly Glu Val Glu Tyr Thr Asp Thr Gln Gly Leu
Gln 130 135 140 Tyr Cys Gly Asn Phe His Phe Thr Ala Ala Ala Gly Leu
Lys Leu Lys 145 150 155 160 Leu Tyr Met 76 163 PRT Artificial
Sequence Description of Artificial Sequence Synthetic Sequence 76
Glu Phe Ala Ala Ala Ala Thr Gln Pro Ala Glu Leu Ala Ser Leu Asp 1 5
10 15 Glu Ser Gln Ser Arg Glu Ser Leu Ser Glu Thr Ser Pro Ser Thr
Ser 20 25 30 Ser Glu Val Phe Lys Ile Lys Phe Ile Phe Pro Asn Gly
Gly Thr Tyr 35 40 45 Asp Gly Asp Cys Thr Arg Thr His Ser Gly Ile
Cys Glu Arg Asn Gly 50 55 60 Thr Ile Thr His Thr Thr Pro Asn Gly
Ile Val Lys Thr Gly Ser Trp 65 70 75 80 Lys Asp Asp Lys Met Leu Gly
Phe Gly Arg Leu Glu His Phe Ser Met 85 90 95 Ala Val Tyr Glu Gly
Gln Phe Lys Asp Gln Met Phe His Gly Leu Gly 100 105 110 Thr Tyr Thr
Arg Pro Thr Gly Ala Lys Tyr Thr Gly Asn Ser Asn Glu 115 120 125 Asn
Arg Val Glu Gly Glu Gly Thr Tyr Thr Asp Thr Gln Gly Leu Gln 130 135
140 Trp Val Gly Asn Phe His Phe Thr Ala Ala Pro Trp Leu Lys Leu Lys
145 150 155 160 Leu Tyr Met 77 163 PRT Artificial Sequence
Description of Artificial Sequence Synthetic Sequence 77 Glu Phe
Ala Ala Ala Ser Ala Gln Pro Ala Glu Leu Ala Ser Leu Gly 1 5 10 15
Asp Ser Gln Ser Arg Glu Ser Leu Ser Phe Glu Ser Pro Ser Thr Ser 20
25 30 Ser Glu Val Tyr Phe Ile Lys Phe Ile Phe Pro Asn Gly Asp Gly
Tyr 35 40 45 Asp Gly Asp Cys Thr Arg Thr Thr His Gly Ile Cys Glu
Arg Asn Gly 50 55 60 Thr Gly Ile His Thr Thr Pro Asn Gly Ile Val
Tyr Lys Gly Ser Trp 65 70 75 80 Lys Asp Asp Lys Met Asn Leu Phe Gly
Arg Leu Glu His Phe Ser Gly 85 90 95 Met Val Tyr Glu Gly Gln Phe
Lys Asp Asn Asn Phe His Gly Leu Gly 100 105 110 Thr Tyr Thr Phe Gln
Thr Gly Ala Lys Tyr Thr Gly Asn Phe Arg Glu 115 120 125 Asn Arg Val
Glu Gly Glu Gly Glu Ser Thr Asp Thr Gln Gly Leu Gln 130 135 140 Trp
Cys Thr Asn Phe His Phe Thr Ala Ala Pro Gly Val Lys Leu Lys 145 150
155 160 Leu Tyr Met 78 163 PRT Artificial Sequence Description of
Artificial Sequence Synthetic Sequence 78 Glu Phe Ala Ala Ala Ser
Thr Ala Pro Ala Glu Leu Ala Ser Leu Gly 1 5 10 15 Glu Asp Gln Ser
Arg Glu Ser Leu Ser Phe Thr Glu Pro Ser Thr Ser 20 25 30 Ser Glu
Val Tyr Lys Phe Lys Phe Ile Phe Pro Asn Gly Asp Thr Gly 35 40 45
Asp Gly Asp Cys Thr Arg Thr Thr Ser His Ile Cys Glu Arg Asn Gly 50
55 60 Thr Gly Thr Ile Thr Thr Pro Asn Gly Ile Val Tyr Thr Lys Ser
Trp 65 70 75 80 Lys Asp Asp Lys Met Asn Gly Leu Gly Arg Leu Glu His
Phe Ser Gly 85 90 95 Ala Met Tyr Glu Gly Gln Phe Lys Asp Asn Met
Asn His Gly Leu Gly 100 105 110 Thr Tyr Thr Phe Pro Gln Gly Ala Lys
Tyr Thr Gly Asn Phe Asn Arg 115 120 125 Asn Arg Val Glu Gly Glu Gly
Glu Tyr Ser Asp Thr Gln Gly Leu Gln 130 135 140 Trp Cys Gly Thr Phe
His Phe Thr Ala Ala Pro Gly Leu Val Leu Lys 145 150 155 160 Leu Tyr
Met 79 163 PRT Artificial Sequence Description of Artificial
Sequence Synthetic Sequence 79 Glu Phe Ala Ala Ala Ser Thr Gln Ala
Ala Glu Leu Ala Ser Leu Gly 1 5 10 15 Glu Ser Asp Ser Arg Glu Ser
Leu Ser Phe Thr Ser Glu Ser Thr Ser 20 25 30 Ser Glu Val Tyr Lys
Ile Phe Phe Ile Phe Pro Asn Gly Asp Thr Tyr 35 40 45 Gly Gly Asp
Cys Thr Arg Thr Thr Ser Gly Gly Cys Glu Arg Asn Gly 50 55 60 Thr
Gly Thr His Ile Thr Pro Asn Gly Ile Val Tyr Thr Gly Lys Trp 65 70
75 80 Lys Asp Asp Lys Met Asn Gly Phe Leu Arg Leu Glu His Phe Ser
Gly 85 90 95 Ala Val Met Glu Gly Gln Phe Lys Asp Asn Met Phe Asn
Gly Leu Gly 100 105 110 Thr Tyr Thr Phe Pro Thr Gln Ala Lys Tyr Thr
Gly Asn Phe Asn Glu 115 120 125 Arg Arg Val Glu Gly Glu Gly Glu Tyr
Thr Ser Thr Gln Gly Leu Gln 130 135 140 Trp Cys Gly Asn Thr His Phe
Thr Ala Ala Pro Gly Leu Lys Val Lys 145 150 155 160 Leu Tyr Met 80
163 PRT Artificial Sequence Description of Artificial Sequence
Synthetic Sequence 80 Glu Phe Ala Ala Ala Ser Thr Gln Pro Asp Glu
Leu Ala Ser Leu Gly 1 5 10 15 Glu Ser Gln Glu Arg Glu Ser Leu Ser
Phe Thr Ser Pro Phe Thr Ser 20 25 30 Ser Glu Val Tyr Lys Ile Lys
Gly Ile Phe Pro Asn Gly Asp Thr Tyr 35 40 45 Asp His Asp Cys Thr
Arg Thr Thr Ser Gly Ile Ile Glu Arg Asn Gly 50 55 60 Thr Gly Thr
His Thr Lys Pro Asn Gly Ile Val Tyr Thr Gly Ser Leu 65 70 75 80 Lys
Asp Asp Lys Met Asn Gly Phe Gly Met Leu Glu His Phe Ser Gly 85 90
95 Ala Val Tyr Asn Gly Gln Phe Lys Asp Asn Met Phe His Gln Leu Gly
100 105 110 Thr Tyr Thr Phe Pro Thr Gly Arg Lys Tyr Thr Gly Asn Phe
Asn Glu 115 120 125 Asn Ser Val Glu Gly Glu Gly Glu Tyr Thr Asp Val
Gln Gly Leu Gln 130 135 140 Trp Cys Gly Asn Phe Trp Phe Thr Ala Ala
Pro Gly Leu Lys Leu Tyr 145 150 155 160 Leu Tyr Met 81 1024 PRT
Artificial Sequence Description of Artificial Sequence Synthetic
Sequence 81 Met Ala Gln Ala Leu Leu Val Pro Pro Gly Pro Glu Ser Phe
Arg Leu 1 5 10 15 Phe Thr Arg Glu Ser Leu Ala Ala Ile Glu Lys Arg
Ala Ala Glu Glu 20 25 30 Lys Ala Lys Lys Pro Lys Lys Glu Gln Asp
Ile Asp Asp Glu Asn Lys 35 40 45 Pro Lys Pro Asn Ser Asp Leu Glu
Ala Gly Lys Asn Leu Pro Phe Ile 50 55 60 Tyr Gly Asp Ile Pro Pro
Glu Met Val Ser Glu Pro Leu Glu Asp Leu 65 70 75 80 Asp Pro Tyr Tyr
Val Ser Lys Lys Thr Phe Val Val Leu Asn Lys Gly 85 90 95 Lys Ala
Ile Phe Arg Phe Ser Ala Thr Ser Ala Leu Tyr Ile Leu Thr 100 105 110
Pro Leu Asn Pro Val Arg Lys Ile Ala Ile Lys Ile Leu Val His Ser 115
120 125 Leu Phe Ser Met Leu Ile Met Cys Thr Ile Leu Thr Asn Cys Val
Phe 130 135 140 Met Thr Leu Ser Asn Pro Pro Asp Trp Thr Lys Asn Val
Glu Tyr Thr 145 150 155 160 Phe Thr Gly Ile Tyr Thr Phe Glu Ser Leu
Ile Lys Ile Leu Ala Arg 165 170 175 Gly Phe Cys Leu Glu Asp Phe Thr
Phe Leu Arg Asp Pro Trp Asn Trp 180 185 190 Leu Asp Phe Ser Val Ile
Val Met Ala Tyr Val Thr Glu Phe Val Asp 195 200 205 Leu Gly Asn Val
Ser Ala Leu Arg Thr Phe Arg Val Leu Arg Ala Leu 210 215 220 Lys Thr
Ile Ser Val Ile Pro Gly Leu Lys Thr Ile Val Gly Ala Leu 225 230 235
240 Ile Gln Ser Val Lys Lys Leu Ser Asp Val Met Ile Leu Thr Val Phe
245 250 255 Cys Leu Ser Val Phe Ala Leu Ile Gly Leu Gln Leu Phe Met
Gly Asn 260 265 270 Leu Arg Asn Lys Cys Ser Gln Trp Pro Pro Ser Asp
Ser Ala Phe Glu 275 280 285 Thr Asn Thr Thr Ser Tyr Phe Asn Gly Thr
Met Asp Ser Asn Gly Thr 290 295 300 Phe Val Asn Val Thr Met Ser Thr
Phe Asn Trp Lys Asp Tyr Ile Ala 305 310 315 320 Asp Asp Ser His Phe
Tyr Val Leu Asp Gly Gln Lys Asp Pro Leu Leu 325 330 335 Cys Gly Asn
Gly Ser Asp Ala Gly Gln Cys Pro Glu Gly Tyr Ile Cys 340 345 350 Val
Lys Ala Gly Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Phe Asp Thr 355 360
365 Phe Ser Trp Ala Phe Leu Ser Leu Phe Arg Leu Met Thr Gln Asp Tyr
370 375 380 Trp Glu Asn Leu Tyr Gln Leu Thr Leu Arg Ala Ala Gly Lys
Thr Tyr 385 390 395 400 Met Ile Phe Phe Val Leu Val Ile Phe Leu Gly
Ser Phe Tyr Leu Val 405 410 415 Asn Leu Ile Leu Ala Val Val Ala Met
Ala Tyr Glu Glu Gln Asn Gln 420 425 430 Ala Thr Leu Glu Glu Ala Glu
Gln Lys Glu Ala Glu Phe Gln Gln Met 435 440 445 Leu Glu Gln Leu Lys
Lys Gln Gln Glu Glu Ala Gln Ala Val Ala Ala 450 455 460 Ala Ser Ala
Ala Ser Arg Asp Phe Ser Gly Ile Gly Gly Leu Gly Glu 465 470 475 480
Leu Leu Glu Ser Ser Ser Glu Ala Ser Lys Leu Ser Ser Lys Ser Ala 485
490 495 Lys Glu Trp Arg Asn Arg Arg Lys Lys Arg Arg Gln Arg Glu His
Leu 500 505 510 Glu Gly Asn His Arg Ala Asp Gly Asp Arg Phe Pro Lys
Ser Glu Ser 515 520 525 Glu Asp Ser Val Lys Arg Arg Ser Phe Leu Leu
Ser Leu Asp Gly Asn 530 535 540 Pro Leu Thr Gly Asp Lys Lys Leu Cys
Ser Pro His Gln Ser Leu Leu 545 550 555 560 Ser Ile Arg Gly Ser Leu
Phe Ser Pro Arg Arg Asn Ser Lys Thr Ser 565 570 575 Ile Phe Ser Phe
Arg Gly Arg Ala Lys Asp Val Gly Ser Glu Asn Asp 580 585 590 Phe Ala
Asp Asp Glu His Ser Thr Phe Glu Asp Ser Glu Ser Arg Arg 595 600 605
Asp Ser Leu Phe Val Pro His Arg Pro Gly Glu Arg Arg Asn Ser Asn 610
615 620 Gly Thr Thr Thr Glu Thr Glu Val Arg Lys Arg Arg Leu Ser Ser
Tyr 625 630 635 640 Gln Ile Ser Met Glu Met Leu Glu Asp Ser Ser Gly
Arg Gln Arg Ser 645 650 655 Met Ser Ile Ala Ser Ile Leu Thr Asn Thr
Met Glu Glu Leu Glu Glu 660 665 670 Ser Arg Gln Lys Cys Pro Pro Cys
Trp Tyr Arg Phe Ala Asn Val Phe 675 680 685 Leu Ile Trp Asp Cys Cys
Asp Ala Trp Leu Lys Val Lys His Leu Val 690 695 700 Asn Leu Ile Val
Met Asp Pro Phe Val Asp Leu Ala Ile Thr Ile Cys 705 710 715 720 Ile
Val Leu Asn Thr Leu Phe Met Ala Met Glu His Tyr Pro Met Thr 725 730
735 Gln Gln Phe Ser Ser Val Leu Thr Val Gly Asn Leu Val Phe Thr Gly
740 745 750 Ile Phe Thr Ala Glu Met Val Leu Lys Ile Ile Ala Met Asp
Pro Tyr 755 760 765 Tyr Tyr Phe Gln Glu Gly Trp Asn Ile Phe Asp Gly
Ile Ile Val Ser 770 775 780 Leu Ser Leu Met Glu Leu Gly Leu Ala Asn
Val Glu Gly Leu Ser Val 785 790 795 800 Leu Arg Ser Phe Arg Leu Leu
Arg Val Phe Lys Leu Ala Lys Ser Trp 805 810 815 Pro Thr Leu Asn Met
Leu Ile Lys Ile Ile Gly Asn Ser Val Gly Ala 820 825 830 Leu Gly Asn
Leu Thr Leu Val Leu Ala Ile Ile Val Phe Ile Phe Ala 835 840 845 Val
Val Gly Met Gln Leu Phe Gly Lys Ser Tyr Lys Glu Cys Val Cys 850 855
860 Lys Ile Asn Val Asp Cys Lys Leu Pro Arg Trp His Met Asn Asp Phe
865 870 875 880 Phe His Ser Phe Leu Ile Val Phe Arg Val Leu Cys Gly
Glu Trp Ile 885 890 895 Glu Thr Met Trp Asp Cys Met Glu Val Ala Gly
Gln Thr Met Cys Leu 900 905 910 Ile Val Phe Met Leu Val Met Val Ile
Gly Asn Leu Val Val Leu Asn 915 920 925 Leu Phe Leu Ala Leu Leu Leu
Ser Ser Phe Ser Ser Asp Asn Leu Ala 930 935 940 Ala Thr Asp Asp Asp
Asn Glu Met Asn Asn Leu Gln Ile Ala Val Gly 945 950 955 960 Arg Met
Gln Lys Gly Ile Asp Phe Val Lys Asn Lys Ile Arg Glu Cys 965 970 975
Phe Arg Lys Ala Phe Phe Arg Lys Pro Lys Val Ile Glu Ile Gln Glu 980
985 990 Gly Asn Lys Ile Asp Ser Cys Met Ser Asn Asn Thr Gly Ile Glu
Ile 995 1000 1005 Ser Lys Glu Leu Asn Tyr Leu Lys Asp Gly Asn Gly
Thr Thr Ser Gly 1010 1015 1020 82 1024 PRT Artificial Sequence
Description of Artificial Sequence Synthetic Sequence 82 Met Asp
Gln Ala Leu Leu Val Pro Pro Gly Pro Phe Ser Phe Arg Leu 1 5 10 15
Phe Thr Arg Glu Ser Gly Ala Ala Ile Glu Lys Arg Ala Ala Glu His 20
25 30 Lys Ala Lys Lys Pro Lys Lys Glu Gln Ile Ile Asp Asp Glu Asn
Lys 35 40 45 Pro Lys Pro Lys Ser Asp Leu Glu Ala Gly Lys Asn Leu
Leu Phe Ile 50 55 60 Tyr Gly Asp Ile Pro Pro Glu Asn Val Ser Glu
Pro Leu Glu Asp Leu 65 70 75 80 Asp Gln Tyr Tyr Val Ser Lys Lys Thr
Phe Val Arg Leu Asn Lys Gly
85 90 95 Lys Ala Ile Phe Arg Ser Ser Ala Thr Ser Ala Leu Tyr Ile
Leu Val 100 105 110 Pro Leu Asn Pro Val Arg Lys Ile Ala Trp Lys Ile
Leu Val His Ser 115 120 125 Leu Phe Ser Tyr Leu Ile Met Cys Thr Ile
Leu Thr Asn Ala Val Phe 130 135 140 Met Thr Leu Ser Asn Pro Pro Glu
Trp Thr Lys Asn Val Glu Tyr Thr 145 150 155 160 Phe Phe Gly Ile Tyr
Thr Phe Glu Ser Leu Ile Gly Ile Leu Ala Arg 165 170 175 Gly Phe Cys
Leu Glu His Phe Thr Phe Leu Arg Asp Pro Trp Asn Ile 180 185 190 Leu
Asp Phe Ser Val Ile Val Met Ala Lys Val Thr Glu Phe Val Asp 195 200
205 Leu Gly Asn Leu Ser Ala Leu Arg Thr Phe Arg Val Leu Met Ala Leu
210 215 220 Lys Thr Ile Ser Val Ile Pro Asn Leu Lys Thr Ile Val Gly
Ala Leu 225 230 235 240 Ile Arg Ser Val Lys Lys Leu Ser Asp Val Met
Ser Leu Thr Val Phe 245 250 255 Cys Leu Ser Val Phe Thr Leu Ile Gly
Leu Gln Leu Phe Met Gly Val 260 265 270 Leu Arg Asn Lys Cys Ser Gln
Trp Pro Trp Ser Asp Ser Ala Phe Glu 275 280 285 Thr Asn Thr Tyr Ser
Tyr Phe Asn Gly Thr Met Asp Ser Ala Gly Thr 290 295 300 Phe Val Asn
Val Thr Met Ser Asp Phe Asn Trp Lys Asp Tyr Ile Ala 305 310 315 320
Asp Glu Ser His Phe Tyr Val Leu Asp Gly Gln Phe Asp Pro Leu Leu 325
330 335 Cys Gly Asn Gly Ser Gly Ala Gly Gln Cys Pro Glu Gly Tyr Ile
His 340 345 350 Val Lys Ala Gly Arg Asn Pro Asn Tyr Ile Tyr Thr Ser
Phe Asp Thr 355 360 365 Phe Ser Trp Lys Phe Leu Ser Leu Phe Arg Leu
Met Thr Leu Asp Tyr 370 375 380 Trp Glu Asn Leu Tyr Gln Leu Met Leu
Arg Ala Ala Gly Lys Thr Tyr 385 390 395 400 Met Asn Phe Phe Val Leu
Val Ile Phe Leu Gly Gln Phe Tyr Leu Val 405 410 415 Asn Leu Ile Leu
Ala Arg Val Ala Met Ala Tyr Glu Glu Gln Asn Ser 420 425 430 Ala Thr
Leu Glu Glu Ala Glu Gln Lys Thr Ala Glu Phe Gln Gln Met 435 440 445
Leu Glu Gln Val Lys Lys Gln Gln Glu Glu Ala Gln Ala Trp Ala Ala 450
455 460 Ala Ser Ala Ala Ser Arg Asp Tyr Ser Gly Ile Gly Gly Leu Gly
Glu 465 470 475 480 Leu Ala Glu Ser Ser Ser Glu Ala Ser Lys Leu Asp
Ser Lys Ser Ala 485 490 495 Lys Glu Trp Arg Asn Glu Arg Lys Lys Arg
Arg Gln Arg Glu His Phe 500 505 510 Glu Gly Asn His Arg Ala Asp Gly
Asp Gly Phe Pro Lys Ser Glu Ser 515 520 525 Glu Asp Ser His Lys Arg
Arg Ser Phe Leu Leu Ser Leu Ile Gly Asn 530 535 540 Pro Leu Thr Gly
Asp Lys Lys Lys Cys Ser Pro His Gln Ser Leu Leu 545 550 555 560 Ser
Leu Arg Gly Ser Leu Phe Ser Pro Arg Arg Met Ser Lys Thr Ser 565 570
575 Ile Phe Ser Phe Arg Asn Arg Ala Lys Asp Val Gly Ser Glu Asn Gln
580 585 590 Phe Ala Asp Asp Glu His Ser Thr Phe Arg Asp Ser Glu Ser
Arg Arg 595 600 605 Asp Ser Leu Ser Val Pro His Arg Pro Gly Glu Arg
Arg Thr Ser Asn 610 615 620 Gly Thr Thr Thr Glu Thr Glu Trp Arg Lys
Arg Arg Leu Ser Ser Tyr 625 630 635 640 Gln Tyr Ser Met Glu Met Leu
Glu Asp Ser Ser Ala Arg Gln Arg Ser 645 650 655 Met Ser Ile Ala Ser
Asp Leu Thr Asn Thr Met Glu Glu Leu Glu Phe 660 665 670 Ser Arg Gln
Lys Cys Pro Pro Cys Trp Gly Arg Phe Ala Asn Val Phe 675 680 685 Leu
Ile Trp His Cys Cys Asp Ala Trp Leu Lys Val Lys Ile Leu Val 690 695
700 Asn Leu Ile Val Met Asp Pro Lys Val Asp Leu Ala Ile Thr Ile Cys
705 710 715 720 Ile Leu Leu Asn Thr Leu Phe Met Ala Met Glu Met Tyr
Pro Met Thr 725 730 735 Gln Gln Phe Ser Ser Asn Leu Thr Val Gly Asn
Leu Val Phe Thr Gln 740 745 750 Ile Phe Thr Ala Glu Met Val Leu Lys
Arg Ile Ala Met Asp Pro Tyr 755 760 765 Tyr Tyr Phe Ser Glu Gly Trp
Asn Ile Phe Asp Gly Ile Thr Val Ser 770 775 780 Leu Ser Leu Met Glu
Leu Gly Val Ala Asn Val Glu Gly Leu Ser Val 785 790 795 800 Leu Trp
Ser Phe Arg Leu Leu Arg Val Phe Lys Tyr Ala Lys Ser Trp 805 810 815
Pro Thr Leu Asn Met Ala Ile Lys Ile Ile Gly Asn Ser Val Gly Asp 820
825 830 Leu Gly Asn Leu Thr Leu Val Leu Ala Glu Ile Val Phe Ile Phe
Ala 835 840 845 Val Val Gly Phe Gln Leu Phe Gly Lys Ser Tyr Lys Glu
Gly Val Cys 850 855 860 Lys Ile Asn Val Asp Cys Lys His Pro Arg Trp
His Met Asn Asp Phe 865 870 875 880 Phe Ile Ser Phe Leu Ile Val Phe
Arg Val Leu Lys Gly Glu Trp Ile 885 890 895 Glu Thr Met Trp Asp Leu
Met Glu Val Ala Gly Gln Thr Met Cys Met 900 905 910 Ile Val Phe Met
Leu Val Met Val Ile Asn Asn Leu Val Val Leu Asn 915 920 925 Leu Phe
Leu Gln Leu Leu Leu Ser Ser Phe Ser Ser Asp Arg Leu Ala 930 935 940
Ala Thr Asp Asp Asp Asn Glu Ser Asn Asn Leu Gln Ile Ala Val Gly 945
950 955 960 Arg Thr Gln Lys Gly Ile Asp Phe Val Lys Asn Val Ile Arg
Glu Cys 965 970 975 Phe Arg Lys Ala Phe Trp Arg Lys Pro Lys Val Ile
Glu Ile Gln Tyr 980 985 990 Gly Asn Lys Ile Asp Ser Cys Met Ser Ala
Asn Thr Gly Ile Glu Ile 995 1000 1005 Ser Lys Glu Asp Asn Tyr Leu
Lys Asp Gly Asn Gly Thr Glu Ser Gly 1010 1015 1020 83 1024 PRT
Artificial Sequence Description of Artificial Sequence Synthetic
Sequence 83 Met Ala Ala Ala Leu Leu Val Pro Pro Gly Pro Glu Asp Phe
Arg Leu 1 5 10 15 Phe Thr Arg Glu Ser Leu Glu Ala Ile Glu Lys Arg
Ala Ala Glu Glu 20 25 30 Phe Ala Lys Lys Pro Lys Lys Glu Gln Asp
Gly Asp Asp Glu Asn Lys 35 40 45 Pro Lys Pro Asn His Asp Leu Glu
Ala Gly Lys Asn Leu Pro Ile Ile 50 55 60 Tyr Gly Asp Ile Pro Pro
Glu Met Lys Ser Glu Pro Leu Glu Asp Leu 65 70 75 80 Asp Pro Leu Tyr
Val Ser Lys Lys Thr Phe Val Val Met Asn Lys Gly 85 90 95 Lys Ala
Ile Phe Arg Phe Asn Ala Thr Ser Ala Leu Tyr Ile Leu Thr 100 105 110
Gln Leu Asn Pro Val Arg Lys Ile Ala Ile Arg Ile Leu Val His Ser 115
120 125 Leu Phe Ser Met Ser Ile Met Cys Thr Ile Leu Thr Asn Cys Thr
Phe 130 135 140 Met Thr Leu Ser Asn Pro Pro Asp Val Thr Lys Asn Val
Glu Tyr Thr 145 150 155 160 Phe Thr Trp Ile Tyr Thr Phe Glu Ser Leu
Ile Lys Tyr Leu Ala Arg 165 170 175 Gly Phe Cys Leu Glu Asp Ala Thr
Phe Leu Arg Asp Pro Trp Asn Trp 180 185 190 Asp Asp Phe Ser Val Ile
Val Met Ala Tyr Glu Thr Glu Phe Val Asp 195 200 205 Leu Gly Asn Val
Phe Ala Leu Arg Thr Phe Arg Val Leu Arg Gly Leu 210 215 220 Lys Thr
Ile Ser Val Ile Pro Gly His Lys Thr Ile Val Gly Ala Leu 225 230 235
240 Ile Gln Ile Val Lys Lys Leu Ser Asp Val Met Ile Lys Thr Val Phe
245 250 255 Cys Leu Ser Val Phe Ala Met Ile Gly Leu Gln Leu Phe Met
Gly Asn 260 265 270 Asn Arg Asn Lys Cys Ser Gln Trp Pro Pro Gln Asp
Ser Ala Phe Glu 275 280 285 Thr Asn Thr Thr Arg Tyr Phe Asn Gly Thr
Met Asp Ser Asn Ser Thr 290 295 300 Phe Val Asn Val Thr Met Ser Thr
Thr Asn Trp Lys Asp Tyr Ile Ala 305 310 315 320 Asp Asp Val His Phe
Tyr Val Leu Asp Gly Gln Lys Trp Pro Leu Leu 325 330 335 Cys Gly Asn
Gly Ser Asp Tyr Gly Gln Cys Pro Glu Gly Tyr Ile Cys 340 345 350 Val
Lys Ala Gly Arg Asn Pro Asn Tyr Gly Trp Thr Ser Phe Asp Thr 355 360
365 Phe Ser Trp Ala Tyr Leu Ser Leu Phe Arg Leu Met Thr Gln Ala Tyr
370 375 380 Trp Glu Asn Leu Tyr Gln Leu Thr Asp Arg Ala Ala Gly Lys
Thr Tyr 385 390 395 400 Met Ile Glu Phe Val Leu Val Ile Phe Leu Gly
Ser Phe Tyr Leu Val 405 410 415 Asn Leu Ile Leu Ala Val Gly Ala Met
Ala Tyr Glu Glu Gln Asn Gln 420 425 430 His Thr Leu Glu Glu Ala Glu
Gln Lys Glu Ile Glu Phe Gln Gln Met 435 440 445 Leu Glu Gln Leu Leu
Lys Gln Gln Glu Glu Ala Gln Ala Val Met Ala 450 455 460 Ala Ser Ala
Ala Ser Arg Asp Phe Asn Gly Ile Gly Gly Leu Gly Glu 465 470 475 480
Leu Leu Gln Ser Ser Ser Glu Ala Ser Lys Leu Ser Arg Lys Ser Ala 485
490 495 Lys Glu Trp Arg Asn Arg Ser Lys Lys Arg Arg Gln Arg Glu His
Leu 500 505 510 Thr Gly Asn His Arg Ala Asp Gly Asp Arg Val Pro Lys
Ser Glu Ser 515 520 525 Glu Asp Ser Val Trp Arg Arg Ser Phe Leu Leu
Ser Leu Asp Tyr Asn 530 535 540 Pro Leu Thr Gly Asp Lys Lys Leu Ala
Ser Pro His Gln Ser Leu Leu 545 550 555 560 Ser Ile Asp Gly Ser Leu
Phe Ser Pro Arg Arg Asn Glu Lys Thr Ser 565 570 575 Ile Phe Ser Phe
Arg Gly Phe Ala Lys Asp Val Gly Ser Glu Asn Asp 580 585 590 Gly Ala
Asp Asp Glu His Ser Thr Phe Glu His Ser Glu Ser Arg Arg 595 600 605
Asp Ser Leu Phe Ile Pro His Arg Pro Gly Glu Arg Arg Asn Lys Asn 610
615 620 Gly Thr Thr Thr Glu Thr Glu Val Leu Lys Arg Arg Leu Ser Ser
Tyr 625 630 635 640 Gln Ile Met Met Glu Met Leu Glu Asp Ser Ser Gly
Asn Gln Arg Ser 645 650 655 Met Ser Ile Ala Ser Ile Gln Thr Asn Thr
Met Glu Glu Leu Glu Glu 660 665 670 Arg Arg Gln Lys Cys Pro Pro Cys
Trp Tyr Ser Phe Ala Asn Val Phe 675 680 685 Leu Ile Trp Asp Thr Cys
Asp Ala Trp Leu Lys Val Lys His Val Val 690 695 700 Asn Leu Ile Val
Met Asp Pro Phe Trp Asp Leu Ala Ile Thr Ile Cys 705 710 715 720 Ile
Val Tyr Asn Thr Leu Phe Met Ala Met Glu His Ala Pro Met Thr 725 730
735 Gln Gln Phe Ser Ser Val Asp Thr Val Gly Asn Leu Val Phe Thr Gly
740 745 750 Glu Phe Thr Ala Glu Met Val Leu Lys Ile Phe Ala Met Asp
Pro Tyr 755 760 765 Tyr Tyr Phe Gln Gly Gly Trp Asn Ile Phe Asp Gly
Ile Ile His Ser 770 775 780 Leu Ser Leu Met Glu Leu Gly Leu Ile Asn
Val Glu Gly Leu Ser Val 785 790 795 800 Leu Arg Lys Phe Arg Leu Leu
Arg Val Phe Lys Leu Leu Lys Ser Trp 805 810 815 Pro Thr Leu Asn Met
Leu Met Lys Ile Ile Gly Asn Ser Val Gly Ala 820 825 830 Asn Gly Asn
Leu Thr Leu Val Leu Ala Ile Gln Val Phe Ile Phe Ala 835 840 845 Val
Val Gly Met Arg Leu Phe Gly Lys Ser Tyr Lys Glu Cys Ser Cys 850 855
860 Lys Ile Asn Val Asp Cys Lys Leu Thr Arg Trp His Met Asn Asp Phe
865 870 875 880 Phe His Val Phe Leu Ile Val Phe Arg Val Leu Cys Trp
Glu Trp Ile 885 890 895 Glu Thr Met Trp Asp Cys Tyr Glu Val Ala Gly
Gln Thr Met Cys Leu 900 905 910 Ala Val Phe Met Leu Val Met Val Ile
Gly Asp Leu Val Val Leu Asn 915 920 925 Leu Phe Leu Ala Glu Leu Leu
Ser Ser Phe Ser Ser Asp Asn Phe Ala 930 935 940 Ala Thr Asp Asp Asp
Asn Glu Met Gly Asn Leu Gln Ile Ala Val Gly 945 950 955 960 Arg Met
His Lys Gly Ile Asp Phe Val Lys Asn Lys Lys Arg Glu Cys 965 970 975
Phe Arg Lys Ala Phe Phe Leu Lys Pro Lys Val Ile Glu Ile Gln Glu 980
985 990 Met Asn Lys Ile Asp Ser Cys Met Ser Asn Gln Thr Gly Ile Glu
Ile 995 1000 1005 Ser Lys Glu Leu Arg Tyr Leu Lys Asp Gly Asn Gly
Thr Thr Thr Gly 1010 1015 1020 84 1024 PRT Artificial Sequence
Description of Artificial Sequence Synthetic Sequence 84 Met Ala
Gln Asp Leu Leu Val Pro Pro Gly Pro Glu Ser Glu Arg Leu 1 5 10 15
Phe Thr Arg Glu Ser Leu Ala Phe Ile Glu Lys Arg Ala Ala Glu Glu 20
25 30 Lys Gly Lys Lys Pro Lys Lys Glu Gln Asp Ile His Asp Glu Asn
Lys 35 40 45 Pro Lys Pro Asn Ser Ile Leu Glu Ala Gly Lys Asn Leu
Pro Phe Lys 50 55 60 Tyr Gly Asp Ile Pro Pro Glu Met Val Leu Glu
Pro Leu Glu Asp Leu 65 70 75 80 Asp Pro Tyr Met Val Ser Lys Lys Thr
Phe Val Val Leu Gln Lys Gly 85 90 95 Lys Ala Ile Phe Arg Phe Ser
Arg Thr Ser Ala Leu Tyr Ile Leu Thr 100 105 110 Pro Ser Asn Pro Val
Arg Lys Ile Ala Ile Lys Thr Leu Val His Ser 115 120 125 Leu Phe Ser
Met Leu Val Met Cys Thr Ile Leu Thr Asn Cys Val Trp 130 135 140 Met
Thr Leu Ser Asn Pro Pro Asp Trp Tyr Lys Asn Val Glu Tyr Thr 145 150
155 160 Phe Thr Gly Ala Tyr Thr Phe Glu Ser Leu Ile Lys Ile Asp Ala
Arg 165 170 175 Gly Phe Cys Leu Glu Asp Phe Glu Phe Leu Arg Asp Pro
Trp Asn Trp 180 185 190 Leu Phe Phe Ser Val Ile Val Met Ala Tyr Val
Gly Glu Phe Val Asp 195 200 205 Leu Gly Asn Val Ser His Leu Arg Thr
Phe Arg Val Leu Arg Ala Ile 210 215 220 Lys Thr Ile Ser Val Ile Pro
Gly Leu Leu Thr Ile Val Gly Ala Leu 225 230 235 240 Ile Gln Ser Met
Lys Lys Leu Ser Asp Val Met Ile Leu Asn Val Phe 245 250 255 Cys Leu
Ser Val Phe Ala Leu Gln Gly Leu Gln Leu Phe Met Gly Asn 260 265 270
Leu Ser Asn Lys Cys Ser Gln Trp Pro Pro Ser Thr Ser Ala Phe Glu 275
280 285 Thr Asn Thr Thr Ser Val Phe Asn Gly Thr Met Asp Ser Asn Gly
Trp 290 295 300 Phe Val Asn Val Thr Met Ser Thr Phe Tyr Trp Lys Asp
Tyr Ile Ala 305 310 315 320 Asp Asp Ser Ala Phe Tyr Val Leu Asp Gly
Gln Lys Asp Asp Leu Leu 325 330 335 Cys Gly Asn Gly Ser Asp Ala Glu
Gln Cys Pro Glu Gly Tyr Ile Cys 340 345 350 Val Phe Ala Gly Arg Asn
Pro Asn Tyr Gly Tyr Gly Ser Phe Asp Thr 355 360 365 Phe Ser Trp Ala
Phe His Ser Leu Phe Arg Leu Met Thr Gln Asp Ile 370 375 380 Trp Glu
Asn Leu Tyr Gln Leu Thr Leu Lys Ala Ala Gly Lys Thr Tyr 385 390 395
400 Met Ile Phe Leu Val Leu Val Ile Phe Leu Gly Ser Phe Met Leu Val
405 410 415 Asn Leu Ile Leu Ala Val Val Asn Met Ala Tyr Glu Glu Gln
Asn Gln 420 425 430 Ala Gln Leu Glu Glu Ala Glu Gln Lys Glu Ala Arg
Phe Gln Gln Met 435 440 445 Leu Glu Gln Leu Lys Ser Gln Gln Glu Glu
Ala Gln Ala Val Ala Thr 450 455 460 Ala Ser Ala Ala Ser Arg Asp Phe
Ser
Val Ile Gly Gly Leu Gly Glu 465 470 475 480 Leu Leu Glu Trp Ser Ser
Glu Ala Ser Lys Leu Ser Ser Tyr Ser Ala 485 490 495 Lys Glu Trp Arg
Asn Arg Arg Ala Lys Arg Arg Gln Arg Glu His Leu 500 505 510 Glu Asp
Asn His Arg Ala Asp Gly Asp Arg Phe Glu Lys Ser Glu Ser 515 520 525
Glu Asp Ser Val Lys Phe Arg Ser Phe Leu Leu Ser Leu Asp Gly Gly 530
535 540 Pro Leu Thr Gly Asp Lys Lys Leu Cys His Pro His Gln Ser Leu
Leu 545 550 555 560 Ser Ile Arg Ile Ser Leu Phe Ser Pro Arg Arg Asn
Ser Leu Thr Ser 565 570 575 Ile Phe Ser Phe Arg Gly Arg Met Lys Asp
Val Gly Ser Glu Asn Asp 580 585 590 Phe Asn Asp Asp Glu His Ser Thr
Phe Glu Asp Gln Glu Ser Arg Arg 595 600 605 Asp Ser Leu Phe Val Arg
His Arg Pro Gly Glu Arg Arg Asn Ser Ser 610 615 620 Gly Thr Thr Thr
Glu Thr Glu Val Arg Thr Arg Arg Leu Ser Ser Tyr 625 630 635 640 Gln
Ile Ser Val Glu Met Leu Glu Asp Ser Ser Gly Arg Trp Arg Ser 645 650
655 Met Ser Ile Ala Ser Ile Leu Tyr Asn Thr Met Glu Glu Leu Glu Glu
660 665 670 Ser Ala Gln Lys Cys Pro Pro Cys Trp Tyr Arg Asp Ala Asn
Val Phe 675 680 685 Leu Ile Trp Asp Cys Glu Asp Ala Trp Leu Lys Val
Lys His Leu Phe 690 695 700 Asn Leu Ile Val Met Asp Pro Phe Val Gly
Leu Ala Ile Thr Ile Cys 705 710 715 720 Ile Val Leu His Thr Leu Phe
Met Ala Met Glu His Tyr Ile Met Thr 725 730 735 Gln Gln Phe Ser Ser
Val Leu Lys Val Gly Asn Leu Val Phe Thr Gly 740 745 750 Ile Leu Thr
Ala Glu Met Val Leu Lys Ile Ile Met Met Asp Pro Tyr 755 760 765 Tyr
Tyr Phe Gln Glu Asn Trp Asn Ile Phe Asp Gly Ile Ile Val Gln 770 775
780 Leu Ser Leu Met Glu Leu Gly Leu Ala Arg Val Glu Gly Leu Ser Val
785 790 795 800 Leu Arg Ser Ser Arg Leu Leu Arg Val Phe Lys Leu Ala
Thr Ser Trp 805 810 815 Pro Thr Leu Asn Met Leu Ile Val Ile Ile Gly
Asn Ser Val Gly Ala 820 825 830 Leu Trp Asn Leu Thr Leu Val Leu Ala
Ile Ile Tyr Phe Ile Phe Ala 835 840 845 Val Val Gly Met Gln Ala Phe
Gly Lys Ser Tyr Lys Glu Cys Val Asp 850 855 860 Lys Ile Asn Val Asp
Cys Lys Leu Pro Glu Trp His Met Asn Asp Phe 865 870 875 880 Phe His
Ser Gly Leu Ile Val Phe Arg Val Leu Cys Gly His Trp Ile 885 890 895
Glu Thr Met Trp Asp Cys Met Ile Val Ala Gly Gln Thr Met Cys Leu 900
905 910 Ile Lys Phe Met Leu Val Met Val Ile Gly Asn Met Val Val Leu
Asn 915 920 925 Leu Phe Leu Ala Leu Asn Leu Ser Ser Phe Ser Ser Asp
Asn Leu Gln 930 935 940 Ala Thr Asp Asp Asp Asn Glu Met Asn Arg Leu
Gln Ile Ala Val Gly 945 950 955 960 Arg Met Gln Ser Gly Ile Asp Phe
Val Lys Asn Lys Ile Thr Glu Cys 965 970 975 Phe Arg Lys Ala Phe Phe
Arg Val Pro Lys Val Ile Glu Ile Gln Glu 980 985 990 Gly Trp Lys Ile
Asp Ser Cys Met Ser Asn Asn Tyr Gly Ile Glu Ile 995 1000 1005 Ser
Lys Glu Leu Asn Ala Leu Lys Asp Gly Asn Gly Thr Thr Ser Asp 1010
1015 1020 85 1024 PRT Artificial Sequence Description of Artificial
Sequence Synthetic Sequence 85 Met Ala Gln Ala Ala Leu Val Pro Pro
Gly Pro Glu Ser Phe Asp Leu 1 5 10 15 Phe Thr Arg Glu Ser Leu Ala
Ala Glu Glu Lys Arg Ala Ala Glu Glu 20 25 30 Lys Ala Phe Lys Pro
Lys Lys Glu Gln Asp Ile Asp Gly Glu Asn Lys 35 40 45 Pro Lys Pro
Asn Ser Asp His Glu Ala Gly Lys Asn Leu Pro Phe Ile 50 55 60 Ile
Gly Asp Ile Pro Pro Glu Met Val Ser Lys Pro Leu Glu Asp Leu 65 70
75 80 Asp Pro Tyr Tyr Leu Ser Lys Lys Thr Phe Val Val Leu Asn Met
Gly 85 90 95 Lys Ala Ile Phe Arg Phe Ser Ala Asn Ser Ala Leu Tyr
Ile Leu Thr 100 105 110 Pro Leu Gln Pro Val Arg Lys Ile Ala Ile Lys
Ile Arg Val His Ser 115 120 125 Leu Phe Ser Met Leu Ile Ser Cys Thr
Ile Leu Thr Asn Cys Val Phe 130 135 140 Thr Thr Leu Ser Asn Pro Pro
Asp Trp Thr Val Asn Val Glu Tyr Thr 145 150 155 160 Phe Thr Gly Ile
Trp Thr Phe Glu Ser Leu Ile Lys Ile Leu Tyr Arg 165 170 175 Gly Phe
Cys Leu Glu Asp Phe Thr Ala Leu Arg Asp Pro Trp Asn Trp 180 185 190
Leu Asp Asp Ser Val Ile Val Met Ala Tyr Val Thr Glu Phe Val Asp 195
200 205 Leu Gly Asn Val Ser Ala Phe Arg Thr Phe Arg Val Leu Arg Ala
Leu 210 215 220 Gly Thr Ile Ser Val Ile Pro Gly Leu Lys His Ile Val
Gly Ala Leu 225 230 235 240 Ile Gln Ser Val Ile Lys Leu Ser Asp Val
Met Ile Leu Thr Lys Phe 245 250 255 Cys Leu Ser Val Phe Ala Leu Ile
Leu Leu Gln Leu Phe Met Gly Asn 260 265 270 Leu Arg Met Lys Cys Ser
Gln Trp Pro Pro Ser Asp Asn Ala Phe Glu 275 280 285 Thr Asn Thr Thr
Ser Tyr Gln Asn Gly Thr Met Asp Ser Asn Gly Thr 290 295 300 Arg Val
Asn Val Thr Met Ser Thr Phe Asn Ser Lys Asp Tyr Ile Ala 305 310 315
320 Asp Asp Ser His Thr Tyr Val Leu Asp Gly Gln Lys Asp Pro Val Leu
325 330 335 Cys Gly Asn Gly Ser Asp Ala Gly Trp Cys Pro Glu Gly Tyr
Ile Cys 340 345 350 Val Lys Tyr Gly Arg Asn Pro Asn Tyr Gly Tyr Thr
Ala Phe Asp Thr 355 360 365 Phe Ser Trp Ala Phe Leu Asp Leu Phe Arg
Leu Met Thr Gln Asp Tyr 370 375 380 Glu Glu Asn Leu Tyr Gln Leu Thr
Leu Arg Phe Ala Gly Lys Thr Tyr 385 390 395 400 Met Ile Phe Phe Gly
Leu Val Ile Phe Leu Gly Ser Phe Tyr His Val 405 410 415 Asn Leu Ile
Leu Ala Val Val Ala Ile Ala Tyr Glu Glu Gln Asn Gln 420 425 430 Ala
Thr Lys Glu Glu Ala Glu Gln Lys Glu Ala Glu Leu Gln Gln Met 435 440
445 Leu Glu Gln Leu Lys Lys Met Gln Glu Glu Ala Gln Ala Val Ala Ala
450 455 460 Asn Ser Ala Ala Ser Arg Asp Phe Ser Gly Gln Gly Gly Leu
Gly Glu 465 470 475 480 Leu Leu Glu Ser Arg Ser Glu Ala Ser Lys Leu
Ser Ser Lys Thr Ala 485 490 495 Lys Glu Trp Arg Asn Arg Arg Lys Val
Arg Arg Gln Arg Glu His Leu 500 505 510 Glu Gly Trp His Arg Ala Asp
Gly Asp Arg Phe Pro Tyr Ser Glu Ser 515 520 525 Glu Asp Ser Val Lys
Arg Ala Ser Phe Leu Leu Ser Leu Asp Gly Asn 530 535 540 Asp Leu Thr
Gly Asp Lys Lys Leu Cys Ser Glu His Gln Ser Leu Leu 545 550 555 560
Ser Ile Arg Gly Phe Leu Phe Ser Pro Arg Arg Asn Ser Lys Gly Ser 565
570 575 Ile Phe Ser Phe Arg Gly Arg Ala His Asp Val Gly Ser Glu Asn
Asp 580 585 590 Phe Ala Ile Asp Glu His Ser Thr Phe Glu Asp Ser Lys
Ser Arg Arg 595 600 605 Asp Ser Leu Phe Val Pro Leu Arg Pro Gly Glu
Arg Arg Asn Ser Asn 610 615 620 Met Thr Thr Thr Glu Thr Glu Val Arg
Lys Asn Arg Leu Ser Ser Tyr 625 630 635 640 Gln Ile Ser Met Gln Met
Leu Glu Asp Ser Ser Gly Arg Gln Ser Ser 645 650 655 Met Ser Ile Ala
Ser Ile Leu Thr Thr Thr Met Glu Glu Leu Glu Glu 660 665 670 Ser Arg
Val Lys Cys Pro Pro Cys Trp Tyr Arg Phe Trp Asn Val Phe 675 680 685
Leu Ile Trp Asp Cys Cys Tyr Ala Trp Leu Lys Val Lys His Leu Val 690
695 700 Ala Leu Ile Val Met Asp Pro Phe Val Asp Asp Ala Ile Thr Ile
Cys 705 710 715 720 Ile Val Leu Asn Glu Leu Phe Met Ala Met Glu His
Tyr Pro Phe Thr 725 730 735 Gln Gln Phe Ser Ser Val Leu Thr Gly Gly
Asn Leu Val Phe Thr Gly 740 745 750 Ile Phe His Ala Glu Met Val Leu
Lys Ile Ile Ala Ile Asp Pro Tyr 755 760 765 Tyr Tyr Phe Gln Glu Gly
Lys Asn Ile Phe Asp Gly Ile Ile Val Ser 770 775 780 Met Ser Leu Met
Glu Leu Gly Leu Ala Asn Asn Glu Gly Leu Ser Val 785 790 795 800 Leu
Arg Ser Phe Gln Leu Leu Arg Val Phe Lys Leu Ala Lys Arg Trp 805 810
815 Pro Thr Leu Asn Met Leu Ile Lys Ser Ile Gly Asn Ser Val Gly Ala
820 825 830 Leu Gly Thr Leu Thr Leu Val Leu Ala Ile Ile Val Val Ile
Phe Ala 835 840 845 Val Val Gly Met Gln Leu Trp Gly Lys Ser Tyr Lys
Glu Cys Val Cys 850 855 860 Tyr Ile Asn Val Asp Cys Lys Leu Pro Arg
Ala His Met Asn Asp Phe 865 870 875 880 Phe His Ser Phe Asp Ile Val
Phe Arg Val Leu Cys Gly Glu Glu Ile 885 890 895 Glu Thr Met Trp Asp
Cys Met Glu Phe Ala Gly Gln Thr Met Cys Leu 900 905 910 Ile Val Gly
Met Leu Val Met Val Ile Gly Asn Leu His Val Leu Asn 915 920 925 Leu
Phe Leu Ala Leu Leu Ile Ser Ser Phe Ser Ser Asp Asn Leu Ala 930 935
940 Lys Thr Asp Asp Asp Asn Glu Met Asn Asn Met Gln Ile Ala Val Gly
945 950 955 960 Arg Met Gln Lys Asn Ile Asp Phe Val Lys Asn Lys Ile
Arg Gln Cys 965 970 975 Phe Arg Lys Ala Phe Phe Arg Lys Arg Lys Val
Ile Glu Ile Gln Glu 980 985 990 Gly Asn Ser Ile Asp Ser Cys Met Ser
Asn Asn Thr Thr Ile Glu Ile 995 1000 1005 Ser Lys Glu Leu Asn Tyr
Val Lys Asp Gly Asn Gly Thr Thr Ser Gly 1010 1015 1020 86 1024 PRT
Artificial Sequence Description of Artificial Sequence Synthetic
Sequence 86 Met Ala Gln Ala Leu Ala Val Pro Pro Gly Pro Glu Ser Phe
Arg Asp 1 5 10 15 Phe Thr Arg Glu Ser Leu Ala Ala Ile Phe Lys Arg
Ala Ala Glu Glu 20 25 30 Lys Ala Lys Gly Pro Lys Lys Glu Gln Asp
Ile Asp Asp His Asn Lys 35 40 45 Pro Lys Pro Asn Ser Asp Leu Ile
Ala Gly Lys Asn Leu Pro Phe Ile 50 55 60 Tyr Lys Asp Ile Pro Pro
Glu Met Val Ser Glu Leu Leu Glu Asp Leu 65 70 75 80 Asp Pro Tyr Tyr
Val Met Lys Lys Thr Phe Val Val Leu Asn Lys Asn 85 90 95 Lys Ala
Ile Phe Arg Phe Ser Ala Thr Gln Ala Leu Tyr Ile Leu Thr 100 105 110
Pro Leu Asn Arg Val Arg Lys Ile Ala Ile Lys Ile Leu Ser His Ser 115
120 125 Leu Phe Ser Met Leu Ile Met Thr Thr Ile Leu Thr Asn Cys Val
Phe 130 135 140 Met Val Leu Ser Asn Pro Pro Asp Trp Thr Lys Trp Val
Glu Tyr Thr 145 150 155 160 Phe Thr Gly Ile Tyr Tyr Phe Glu Ser Leu
Ile Lys Ile Leu Ala Ala 165 170 175 Gly Phe Cys Leu Glu Asp Phe Thr
Phe Asp Arg Asp Pro Trp Asn Trp 180 185 190 Leu Asp Phe Glu Val Ile
Val Met Ala Tyr Val Thr Glu Gly Val Asp 195 200 205 Leu Gly Asn Val
Ser Ala Leu His Thr Phe Arg Val Leu Arg Ala Leu 210 215 220 Lys Ile
Ile Ser Val Ile Pro Gly Leu Lys Thr Lys Val Gly Ala Leu 225 230 235
240 Ile Gln Ser Val Lys Leu Leu Ser Asp Val Met Ile Leu Thr Val Met
245 250 255 Cys Leu Ser Val Phe Ala Leu Ile Gly Asn Gln Leu Phe Met
Gly Asn 260 265 270 Leu Arg Asn Gln Cys Ser Gln Trp Pro Pro Ser Asp
Ser Arg Phe Glu 275 280 285 Thr Asn Thr Thr Ser Tyr Phe Ser Gly Thr
Met Asp Ser Asn Gly Thr 290 295 300 Phe Thr Asn Val Thr Met Ser Thr
Phe Asn Trp Val Asp Tyr Ile Ala 305 310 315 320 Asp Asp Ser His Phe
Trp Val Leu Asp Gly Gln Lys Asp Pro Leu Tyr 325 330 335 Cys Gly Asn
Gly Ser Asp Ala Gly Gln Ala Pro Glu Gly Tyr Ile Cys 340 345 350 Val
Lys Ala Asp Arg Asn Pro Asn Tyr Gly Tyr Thr Ser Glu Asp Thr 355 360
365 Phe Ser Trp Ala Phe Leu Ser Phe Phe Arg Leu Met Thr Gln Asp Tyr
370 375 380 Trp Gly Asn Leu Tyr Gln Leu Thr Leu Arg Ala His Gly Lys
Thr Tyr 385 390 395 400 Met Ile Phe Phe Val Ile Val Ile Phe Leu Gly
Ser Phe Tyr Leu Lys 405 410 415 Asn Leu Ile Leu Ala Val Val Ala Met
Leu Tyr Glu Glu Gln Asn Gln 420 425 430 Ala Thr Leu Met Glu Ala Glu
Gln Lys Glu Ala Glu Phe Asn Gln Met 435 440 445 Leu Glu Gln Leu Lys
Lys Gln Arg Glu Glu Ala Gln Ala Val Ala Ala 450 455 460 Ala Thr Ala
Ala Ser Arg Asp Phe Ser Gly Ile Val Gly Leu Gly Glu 465 470 475 480
Leu Leu Glu Ser Ser Trp Glu Ala Ser Lys Leu Ser Ser Lys Ser Tyr 485
490 495 Lys Glu Trp Arg Asn Arg Arg Lys Lys Ala Arg Gln Arg Glu His
Leu 500 505 510 Glu Gly Asn Asp Arg Ala Asp Gly Asp Arg Phe Pro Lys
Glu Glu Ser 515 520 525 Glu Asp Ser Val Lys Arg Arg Phe Phe Leu Leu
Ser Leu Asp Gly Asn 530 535 540 Pro Gly Thr Gly Asp Lys Lys Leu Cys
Ser Pro Ile Gln Ser Leu Leu 545 550 555 560 Ser Ile Arg Gly Ser Lys
Phe Ser Pro Arg Arg Asn Ser Lys Thr Leu 565 570 575 Ile Phe Ser Phe
Arg Gly Arg Ala Lys Met Val Gly Ser Glu Asn Asp 580 585 590 Phe Ala
Asp Asn Glu His Ser Thr Phe Glu Asp Ser Glu Gln Arg Arg 595 600 605
Asp Ser Leu Phe Val Pro His Ser Pro Gly Glu Arg Arg Asn Ser Asn 610
615 620 Gly Val Thr Thr Glu Thr Glu Val Arg Lys Arg Trp Leu Ser Ser
Tyr 625 630 635 640 Gln Ile Ser Met Glu Tyr Leu Glu Asp Ser Ser Gly
Arg Gln Arg Ala 645 650 655 Met Ser Ile Ala Ser Ile Leu Thr Asn Asp
Met Glu Glu Leu Glu Glu 660 665 670 Ser Arg Gln Glu Cys Pro Pro Cys
Trp Tyr Arg Phe Ala Phe Val Phe 675 680 685 Leu Ile Trp Asp Cys Cys
Asp Gly Trp Leu Lys Val Lys His Leu Val 690 695 700 Asn His Ile Val
Met Asp Pro Phe Val Asp Leu Ile Ile Thr Ile Cys 705 710 715 720 Ile
Val Leu Asn Thr Lys Phe Met Ala Met Glu His Tyr Pro Met Leu 725 730
735 Gln Gln Phe Ser Ser Val Leu Thr Val Met Asn Leu Val Phe Thr Gly
740 745 750 Ile Phe Thr Asn Glu Met Val Leu Lys Ile Ile Ala Met Gln
Pro Tyr 755 760 765 Tyr Tyr Phe Gln Glu Gly Trp Arg Ile Phe Asp Gly
Ile Ile Val Ser 770 775 780 Leu Thr Leu Met Glu Leu Gly Leu Ala Asn
Val Val Gly Leu Ser Val 785 790 795 800 Leu Arg Ser Phe Arg Trp Leu
Arg Val Phe Lys Leu Ala Lys Ser Tyr 805 810 815 Pro Thr Leu Asn Met
Leu Ile Lys Ile Ala Gly Asn Ser Val Gly Ala 820 825 830 Leu Gly Asn
Asp Thr Leu Val Leu Ala Ile Ile Val Phe Glu Phe Ala 835 840 845
Val Val Gly Met Gln Leu Phe Phe Lys Ser Tyr Lys Glu Cys Val Cys 850
855 860 Lys Gly Asn Val Asp Cys Lys Leu Pro Arg Trp Ile Met Asn Asp
Phe 865 870 875 880 Phe His Ser Phe Leu Lys Val Phe Arg Val Leu Cys
Gly Glu Trp Leu 885 890 895 Glu Thr Met Trp Asp Cys Met Glu Val Met
Gly Gln Thr Met Cys Leu 900 905 910 Ile Val Phe Asn Leu Val Met Val
Ile Gly Asn Leu Val Gln Leu Asn 915 920 925 Leu Phe Leu Ala Leu Leu
Leu Arg Ser Phe Ser Ser Asp Asn Leu Ala 930 935 940 Ala Ser Asp Asp
Asp Asn Glu Met Asn Asn Leu Thr Ile Ala Val Gly 945 950 955 960 Arg
Met Gln Lys Gly Val Asp Phe Val Lys Asn Lys Ile Arg Glu Ala 965 970
975 Phe Arg Lys Ala Phe Phe Arg Lys Pro Asp Val Ile Glu Ile Gln Glu
980 985 990 Gly Asn Lys Glu Asp Ser Cys Met Ser Asn Asn Thr Gly Phe
Glu Ile 995 1000 1005 Ser Lys Glu Leu Asn Tyr Leu Gly Asp Gly Asn
Gly Thr Thr Ser Gly 1010 1015 1020 87 1024 PRT Artificial Sequence
Description of Artificial Sequence Synthetic Sequence 87 Met Ala
Gln Ala Leu Leu Ala Pro Pro Gly Pro Glu Ser Phe Arg Leu 1 5 10 15
Asp Thr Arg Glu Ser Leu Ala Ala Ile Glu Glu Arg Ala Ala Glu Glu 20
25 30 Lys Ala Lys Lys Phe Lys Lys Glu Gln Asp Ile Asp Asp Glu Gly
Lys 35 40 45 Pro Lys Pro Asn Ser Asp Leu Glu His Gly Lys Asn Leu
Pro Phe Ile 50 55 60 Tyr Gly Ile Ile Pro Pro Glu Met Val Ser Glu
Pro Lys Glu Asp Leu 65 70 75 80 Asp Pro Tyr Tyr Val Ser Leu Lys Thr
Phe Val Val Leu Asn Lys Gly 85 90 95 Met Ala Ile Phe Arg Phe Ser
Ala Thr Ser Asn Leu Tyr Ile Leu Thr 100 105 110 Pro Leu Asn Pro Gln
Arg Lys Ile Ala Ile Lys Ile Leu Val Arg Ser 115 120 125 Leu Phe Ser
Met Leu Ile Met Cys Ser Ile Leu Thr Asn Cys Val Phe 130 135 140 Met
Thr Thr Ser Asn Pro Pro Asp Trp Thr Lys Asn Trp Glu Tyr Thr 145 150
155 160 Phe Thr Gly Ile Tyr Thr Tyr Glu Ser Leu Ile Lys Ile Leu Ala
Arg 165 170 175 Ala Phe Cys Leu Glu Asp Phe Thr Phe Leu Asp Asp Pro
Trp Asn Trp 180 185 190 Leu Asp Phe Ser Glu Ile Val Met Ala Tyr Val
Thr Glu Phe Phe Asp 195 200 205 Leu Gly Asn Val Ser Ala Leu Arg Gly
Phe Arg Val Leu Arg Ala Leu 210 215 220 Lys Thr His Ser Val Ile Pro
Gly Leu Lys Thr Ile Ile Gly Ala Leu 225 230 235 240 Ile Gln Ser Val
Lys Lys Lys Ser Asp Val Met Ile Leu Thr Val Phe 245 250 255 Leu Leu
Ser Val Phe Ala Leu Ile Gly Leu Met Leu Phe Met Gly Asn 260 265 270
Leu Arg Asn Lys Asn Ser Gln Trp Pro Pro Ser Asp Ser Ala Gln Glu 275
280 285 Thr Asn Thr Thr Ser Tyr Phe Asn Arg Thr Met Asp Ser Asn Gly
Thr 290 295 300 Phe Val Ser Val Thr Met Ser Thr Phe Asn Trp Lys Thr
Tyr Ile Ala 305 310 315 320 Asp Asp Ser His Phe Tyr Trp Leu Asp Gly
Gln Lys Asp Pro Leu Leu 325 330 335 Tyr Gly Asn Gly Ser Asp Ala Gly
Gln Cys Ala Glu Gly Tyr Ile Cys 340 345 350 Val Lys Ala Gly Asp Asn
Pro Asn Tyr Gly Tyr Thr Ser Phe Glu Thr 355 360 365 Phe Ser Trp Ala
Phe Leu Ser Leu Gly Arg Leu Met Thr Gln Asp Tyr 370 375 380 Trp Glu
His Leu Tyr Gln Leu Thr Leu Arg Ala Ala Ile Lys Thr Tyr 385 390 395
400 Met Ile Phe Phe Val Leu Lys Ile Phe Leu Gly Ser Phe Tyr Leu Val
405 410 415 Leu Leu Ile Leu Ala Val Val Ala Met Ala Met Glu Glu Gln
Asn Gln 420 425 430 Ala Thr Leu Glu Asn Ala Glu Gln Lys Glu Ala Glu
Phe Gln Arg Met 435 440 445 Leu Glu Gln Leu Lys Lys Gln Gln Ser Glu
Ala Gln Ala Val Ala Ala 450 455 460 Ala Ser Thr Ala Ser Arg Asp Phe
Ser Gly Ile Gly Val Leu Gly Glu 465 470 475 480 Leu Leu Glu Ser Ser
Ser Trp Ala Ser Lys Leu Ser Ser Lys Ser Ala 485 490 495 Tyr Glu Trp
Arg Asn Arg Arg Lys Lys Arg Ala Gln Arg Glu His Leu 500 505 510 Glu
Gly Asn His Asp Ala Asp Gly Asp Arg Phe Pro Lys Ser Phe Ser 515 520
525 Glu Asp Ser Val Lys Arg Arg Ser Gly Leu Leu Ser Leu Asp Gly Asn
530 535 540 Pro Leu His Gly Asp Lys Lys Leu Cys Ser Pro His Ile Ser
Leu Leu 545 550 555 560 Ser Ile Arg Gly Ser Leu Lys Ser Pro Arg Arg
Asn Ser Lys Thr Ser 565 570 575 Leu Phe Ser Phe Arg Gly Arg Ala Lys
Asp Met Gly Ser Glu Asn Asp 580 585 590 Phe Ala Asp Asp Asn His Ser
Thr Phe Glu Asp Ser Glu Ser Gln Arg 595 600 605 Asp Ser Leu Phe Val
Pro His Arg Arg Gly Glu Arg Arg Asn Ser Asn 610 615 620 Gly Thr Ser
Thr Glu Thr Glu Val Arg Lys Arg Arg Thr Ser Ser Tyr 625 630 635 640
Gln Ile Ser Met Glu Met Val Glu Asp Ser Ser Gly Arg Gln Arg Ser 645
650 655 Trp Ser Ile Ala Ser Ile Leu Thr Asn Thr Tyr Glu Glu Leu Glu
Glu 660 665 670 Ser Arg Gln Lys Ala Pro Pro Cys Trp Tyr Arg Phe Ala
Asn Asp Phe 675 680 685 Leu Ile Trp Asp Cys Cys Asp Ala Glu Leu Lys
Val Lys His Leu Val 690 695 700 Asn Leu Phe Val Met Asp Pro Phe Val
Asp Leu Ala Gly Thr Ile Cys 705 710 715 720 Ile Val Leu Asn Thr Leu
His Met Ala Met Glu His Tyr Pro Met Thr 725 730 735 Ile Gln Phe Ser
Ser Val Leu Thr Val Gly Lys Leu Val Phe Thr Gly 740 745 750 Ile Phe
Thr Ala Leu Met Val Leu Lys Ile Ile Ala Met Asp Met Tyr 755 760 765
Tyr Tyr Phe Gln Glu Gly Trp Asn Asn Phe Asp Gly Ile Ile Val Ser 770
775 780 Leu Ser Gln Met Glu Leu Gly Leu Ala Asn Val Glu Arg Leu Ser
Val 785 790 795 800 Leu Arg Ser Phe Arg Leu Ser Arg Val Phe Lys Leu
Ala Lys Ser Trp 805 810 815 Thr Thr Leu Asn Met Leu Ile Lys Ile Ile
Val Asn Ser Val Gly Ala 820 825 830 Leu Gly Asn Leu Trp Leu Val Leu
Ala Ile Ile Val Phe Ile Tyr Ala 835 840 845 Val Val Gly Met Gln Leu
Phe Gly Ala Ser Tyr Lys Glu Cys Val Cys 850 855 860 Lys Ile Asp Val
Asp Cys Lys Leu Pro Arg Trp His Glu Asn Asp Phe 865 870 875 880 Phe
His Ser Phe Leu Ile Phe Phe Arg Val Leu Cys Gly Glu Trp Ile 885 890
895 Gly Thr Met Trp Asp Cys Met Glu Val Ala His Gln Thr Met Cys Leu
900 905 910 Ile Val Phe Met Ile Val Met Val Ile Gly Asn Leu Val Val
Lys Asn 915 920 925 Leu Phe Leu Ala Leu Leu Leu Ser Leu Phe Ser Ser
Asp Asn Leu Ala 930 935 940 Ala Thr Met Asp Asp Asn Glu Met Asn Asn
Leu Gln Asn Ala Val Gly 945 950 955 960 Arg Met Gln Lys Gly Ile Gln
Phe Val Lys Asn Lys Ile Arg Glu Cys 965 970 975 Arg Arg Lys Ala Phe
Phe Arg Lys Pro Lys Ser Ile Glu Ile Gln Glu 980 985 990 Gly Asn Lys
Ile Thr Ser Cys Met Ser Asn Asn Thr Gly Ile Val Ile 995 1000 1005
Ser Lys Glu Leu Asn Tyr Leu Lys Trp Gly Asn Gly Thr Thr Ser Gly
1010 1015 1020 88 1024 PRT Artificial Sequence Description of
Artificial Sequence Synthetic Sequence 88 Met Ala Gln Ala Leu Leu
Val Ala Pro Gly Pro Glu Ser Phe Arg Leu 1 5 10 15 Phe Asp Arg Glu
Ser Leu Ala Ala Ile Glu Lys Glu Ala Ala Glu Glu 20 25 30 Lys Ala
Lys Lys Pro Phe Lys Glu Gln Asp Ile Asp Asp Glu Asn Gly 35 40 45
Pro Lys Pro Asn Ser Asp Leu Glu Ala His Lys Asn Leu Pro Phe Ile 50
55 60 Tyr Gly Asp Lys Pro Pro Glu Met Val Ser Glu Pro Leu Leu Asp
Leu 65 70 75 80 Asp Pro Tyr Tyr Val Ser Lys Met Thr Phe Val Val Leu
Asn Lys Gly 85 90 95 Lys Asn Ile Phe Arg Phe Ser Ala Thr Ser Ala
Gln Tyr Ile Leu Thr 100 105 110 Pro Leu Asn Pro Val Ser Lys Ile Ala
Ile Lys Ile Leu Val His Thr 115 120 125 Leu Phe Ser Met Leu Ile Met
Cys Thr Val Leu Thr Asn Cys Val Phe 130 135 140 Met Thr Leu Trp Asn
Pro Pro Asp Trp Thr Lys Asn Val Tyr Tyr Thr 145 150 155 160 Phe Thr
Gly Ile Tyr Thr Phe Ala Ser Leu Ile Lys Ile Leu Ala Arg 165 170 175
Gly Asp Cys Leu Glu Asp Phe Thr Phe Leu Arg Glu Pro Trp Asn Trp 180
185 190 Leu Asp Phe Ser Val Phe Val Met Ala Tyr Val Thr Glu Phe Val
Gly 195 200 205 Leu Gly Asn Val Ser Ala Leu Arg Thr His Arg Val Leu
Arg Ala Leu 210 215 220 Lys Thr Ile Ile Val Ile Pro Gly Leu Lys Thr
Ile Val Lys Ala Leu 225 230 235 240 Ile Gln Ser Val Lys Lys Leu Leu
Asp Val Met Ile Leu Thr Val Phe 245 250 255 Cys Met Ser Val Phe Ala
Leu Ile Gly Leu Gln Asn Phe Met Gly Asn 260 265 270 Leu Arg Asn Lys
Cys Gln Gln Trp Pro Pro Ser Asp Ser Ala Phe Arg 275 280 285 Thr Asn
Thr Thr Ser Tyr Phe Asn Gly Ser Met Asp Ser Asn Gly Thr 290 295 300
Phe Val Asn Thr Thr Met Ser Thr Phe Asn Trp Lys Asp Val Ile Ala 305
310 315 320 Asp Asp Ser His Phe Tyr Val Trp Asp Gly Gln Lys Asp Pro
Leu Leu 325 330 335 Cys Tyr Asn Gly Ser Asp Ala Gly Gln Cys Pro Ala
Gly Tyr Ile Cys 340 345 350 Val Lys Ala Gly Arg Asp Pro Asn Tyr Gly
Tyr Thr Ser Phe Asp Glu 355 360 365 Phe Ser Trp Ala Phe Leu Ser Leu
Phe Phe Leu Met Thr Gln Asp Tyr 370 375 380 Trp Glu Asn Gly Tyr Gln
Leu Thr Leu Arg Ala Ala Gly His Thr Tyr 385 390 395 400 Met Ile Phe
Phe Val Leu Val Lys Phe Leu Gly Ser Phe Tyr Leu Val 405 410 415 Asn
Met Ile Leu Ala Val Val Ala Met Ala Tyr Asn Glu Gln Asn Gln 420 425
430 Ala Thr Leu Glu Glu Gln Glu Gln Lys Glu Ala Glu Phe Gln Gln Arg
435 440 445 Leu Glu Gln Leu Lys Lys Gln Gln Glu Ser Ala Gln Ala Val
Ala Ala 450 455 460 Ala Ser Ala Thr Ser Arg Asp Phe Ser Gly Ile Gly
Gly Val Gly Glu 465 470 475 480 Leu Leu Glu Ser Ser Ser Glu Trp Ser
Lys Leu Ser Ser Lys Ser Ala 485 490 495 Lys Tyr Trp Arg Asn Arg Arg
Lys Lys Arg Arg Ala Arg Glu His Leu 500 505 510 Glu Gly Asn His Arg
Asp Asp Gly Asp Arg Phe Pro Lys Ser Glu Glu 515 520 525 Glu Asp Ser
Val Lys Arg Arg Ser Phe Phe Leu Ser Leu Asp Gly Asn 530 535 540 Pro
Leu Thr His Asp Lys Lys Leu Cys Ser Pro His Gln Ile Leu Leu 545 550
555 560 Ser Ile Arg Gly Ser Leu Phe Lys Pro Arg Arg Asn Ser Lys Thr
Ser 565 570 575 Ile Leu Ser Phe Arg Gly Arg Ala Lys Asp Val Met Ser
Glu Asn Asp 580 585 590 Phe Ala Asp Asp Glu Asn Ser Thr Phe Glu Asp
Ser Glu Ser Arg Gln 595 600 605 Asp Ser Leu Phe Val Pro His Arg Pro
Arg Glu Arg Arg Asn Ser Asn 610 615 620 Gly Thr Thr Ser Glu Thr Glu
Val Arg Lys Arg Arg Leu Thr Ser Tyr 625 630 635 640 Gln Ile Ser Met
Glu Met Leu Val Asp Ser Ser Gly Arg Gln Arg Ser 645 650 655 Met Trp
Ile Ala Ser Ile Leu Thr Asn Thr Met Tyr Glu Leu Glu Glu 660 665 670
Ser Arg Gln Lys Cys Ala Pro Cys Trp Tyr Arg Phe Ala Asn Val Asp 675
680 685 Leu Ile Trp Asp Cys Cys Asp Ala Trp Glu Lys Val Lys His Leu
Val 690 695 700 Asn Leu Ile Phe Met Asp Pro Phe Val Asp Leu Ala Ile
Gly Ile Cys 705 710 715 720 Ile Val Leu Asn Thr Leu Phe His Ala Met
Glu His Tyr Pro Met Thr 725 730 735 Gln Ile Phe Ser Ser Val Leu Thr
Val Gly Asn Lys Val Phe Thr Gly 740 745 750 Ile Phe Thr Ala Glu Leu
Val Leu Lys Ile Ile Ala Met Asp Pro Met 755 760 765 Tyr Tyr Phe Gln
Glu Gly Trp Asn Ile Asn Asp Gly Ile Ile Val Ser 770 775 780 Leu Ser
Leu Gln Glu Leu Gly Leu Ala Asn Val Glu Gly Arg Ser Val 785 790 795
800 Leu Arg Ser Phe Arg Leu Leu Ser Val Phe Lys Leu Ala Lys Ser Trp
805 810 815 Pro Val Leu Asn Met Leu Ile Lys Ile Ile Gly Trp Ser Val
Gly Ala 820 825 830 Leu Gly Asn Leu Thr Tyr Val Leu Ala Ile Ile Val
Phe Ile Phe Asp 835 840 845 Val Val Gly Met Gln Leu Phe Gly Lys Glu
Tyr Lys Glu Cys Val Cys 850 855 860 Lys Ile Asn Phe Asp Cys Lys Leu
Pro Arg Trp His Met Gly Asp Phe 865 870 875 880 Phe His Ser Phe Leu
Ile Val His Arg Val Leu Cys Gly Glu Trp Ile 885 890 895 Glu Ile Met
Trp Asp Cys Met Glu Val Ala Gly Lys Thr Met Cys Leu 900 905 910 Ile
Val Phe Met Leu Leu Met Val Ile Gly Asn Leu Val Val Leu Met 915 920
925 Leu Phe Leu Ala Leu Leu Leu Ser Ser Asn Ser Ser Asp Asn Leu Ala
930 935 940 Ala Thr Asp Gln Asp Asn Glu Met Asn Asn Leu Gln Ile Arg
Val Gly 945 950 955 960 Arg Met Gln Lys Gly Ile Asp Ser Val Lys Asn
Lys Ile Arg Glu Cys 965 970 975 Phe Thr Lys Ala Phe Phe Arg Lys Pro
Lys Val Val Glu Ile Gln Glu 980 985 990 Gly Asn Lys Ile Asp Trp Cys
Met Ser Asn Asn Thr Gly Ile Glu Tyr 995 1000 1005 Ser Lys Glu Leu
Asn Tyr Leu Lys Asp Ala Asn Gly Thr Thr Ser Gly 1010 1015 1020 89
1024 PRT Artificial Sequence Description of Artificial Sequence
Synthetic Sequence 89 Met Ala Gln Ala Leu Leu Val Pro Ala Gly Pro
Glu Ser Phe Arg Leu 1 5 10 15 Phe Thr Asp Glu Ser Leu Ala Ala Ile
Glu Lys Arg Glu Ala Glu Glu 20 25 30 Lys Ala Lys Lys Pro Lys Phe
Glu Gln Asp Ile Asp Asp Glu Asn Lys 35 40 45 Gly Lys Pro Asn Ser
Asp Leu Glu Ala Gly His Asn Leu Pro Phe Ile 50 55 60 Tyr Gly Asp
Ile Ile Pro Glu Met Val Ser Glu Pro Leu Glu Lys Leu 65 70 75 80 Asp
Pro Tyr Tyr Val Ser Lys Lys Leu Phe Val Val Leu Asn Lys Gly 85 90
95 Lys Ala Met Phe Arg Phe Ser Ala Thr Ser Ala Leu Asn Ile Leu Thr
100 105 110 Pro Leu Asn Pro Val Arg Gln Ile Ala Ile Lys Ile Leu Val
His Ser 115 120 125 Arg Phe Ser Met Leu Ile Met Cys Thr Ile Ser Thr
Asn Cys Val Phe 130 135 140 Met Thr Leu Ser Thr Pro Pro Asp Trp Thr
Lys Asn Val Glu Val Thr 145 150 155 160 Phe Thr Gly Ile Tyr Thr Phe
Glu Trp Leu Ile Lys Ile Leu Ala Arg 165 170 175 Gly Phe Tyr Leu Glu
Asp Phe Thr Phe Leu Arg Asp Ala Trp Asn Trp 180 185 190 Leu Asp
Phe
Ser Val Ile Asp Met Ala Tyr Val Thr Glu Phe Val Asp 195 200 205 Glu
Gly Asn Val Ser Ala Leu Arg Thr Phe Phe Val Leu Arg Ala Leu 210 215
220 Lys Thr Ile Ser Gly Ile Pro Gly Leu Lys Thr Ile Val Gly His Leu
225 230 235 240 Ile Gln Ser Val Lys Lys Leu Ser Ile Val Met Ile Leu
Thr Val Phe 245 250 255 Cys Leu Lys Val Phe Ala Leu Ile Gly Leu Gln
Leu Leu Met Gly Asn 260 265 270 Leu Arg Asn Lys Cys Ser Met Trp Pro
Pro Ser Asp Ser Ala Phe Glu 275 280 285 Asn Asn Thr Thr Ser Tyr Phe
Asn Gly Thr Gln Asp Ser Asn Gly Thr 290 295 300 Phe Val Asn Val Arg
Met Ser Thr Phe Asn Trp Lys Asp Tyr Ser Ala 305 310 315 320 Asp Asp
Ser His Phe Tyr Val Leu Thr Gly Gln Lys Asp Pro Leu Leu 325 330 335
Cys Gly Val Gly Ser Asp Ala Gly Gln Cys Pro Glu Trp Tyr Ile Cys 340
345 350 Val Lys Ala Gly Arg Asn Tyr Asn Tyr Gly Tyr Thr Ser Phe Asp
Thr 355 360 365 Ala Ser Trp Ala Phe Leu Ser Leu Phe Arg Asp Met Thr
Gln Asp Tyr 370 375 380 Trp Glu Asn Leu Glu Gln Leu Thr Leu Arg Ala
Ala Gly Lys Phe Tyr 385 390 395 400 Met Ile Phe Phe Val Leu Val Ile
Gly Leu Gly Ser Phe Tyr Leu Val 405 410 415 Asn Leu His Leu Ala Val
Val Ala Met Ala Tyr Glu Ile Gln Asn Gln 420 425 430 Ala Thr Leu Glu
Glu Ala Lys Gln Lys Glu Ala Glu Phe Gln Gln Met 435 440 445 Met Glu
Gln Leu Lys Lys Gln Gln Glu Glu Asn Gln Ala Val Ala Ala 450 455 460
Ala Ser Ala Ala Gln Arg Asp Phe Ser Gly Ile Gly Gly Leu Arg Glu 465
470 475 480 Leu Leu Glu Ser Ser Ser Glu Ala Thr Lys Leu Ser Ser Lys
Ser Ala 485 490 495 Lys Glu Val Arg Asn Arg Arg Lys Lys Arg Arg Gln
Trp Glu His Leu 500 505 510 Glu Gly Asn His Arg Ala Tyr Gly Asp Arg
Phe Pro Lys Ser Glu Ser 515 520 525 Ala Asp Ser Val Lys Arg Arg Ser
Phe Leu Asp Ser Leu Asp Gly Asn 530 535 540 Pro Leu Thr Gly Glu Lys
Lys Leu Cys Ser Pro His Gln Ser Phe Leu 545 550 555 560 Ser Ile Arg
Gly Ser Leu Phe Ser Gly Arg Arg Asn Ser Lys Thr Ser 565 570 575 Ile
Phe His Phe Arg Gly Arg Ala Lys Asp Val Gly Ile Glu Asn Asp 580 585
590 Phe Ala Asp Asp Glu His Lys Thr Phe Glu Asp Ser Glu Ser Arg Arg
595 600 605 Leu Ser Leu Phe Val Pro His Arg Pro Gly Met Arg Arg Asn
Ser Asn 610 615 620 Gly Thr Thr Thr Asn Thr Glu Val Arg Lys Arg Arg
Leu Ser Gln Tyr 625 630 635 640 Gln Ile Ser Met Glu Met Leu Glu Arg
Ser Ser Gly Arg Gln Arg Ser 645 650 655 Met Ser Ser Ala Ser Ile Leu
Thr Asn Thr Met Glu Thr Leu Glu Glu 660 665 670 Ser Arg Gln Lys Cys
Pro Val Cys Trp Tyr Arg Phe Ala Asn Val Phe 675 680 685 Trp Ile Trp
Asp Cys Cys Asp Ala Trp Leu Tyr Val Lys His Leu Val 690 695 700 Asn
Leu Ile Val Ala Asp Pro Phe Val Asp Leu Ala Ile Thr Asp Cys 705 710
715 720 Ile Val Leu Asn Thr Leu Phe Met Glu Met Glu His Tyr Pro Met
Thr 725 730 735 Gln Gln Gly Ser Ser Val Leu Thr Val Gly Asn Leu His
Phe Thr Gly 740 745 750 Ile Phe Thr Ala Glu Met Ile Leu Lys Ile Ile
Ala Met Asp Pro Tyr 755 760 765 Lys Tyr Phe Gln Glu Gly Trp Asn Ile
Phe Leu Gly Ile Ile Val Ser 770 775 780 Leu Ser Leu Met Met Leu Gly
Leu Ala Asn Val Glu Gly Leu Asn Val 785 790 795 800 Leu Arg Ser Phe
Arg Leu Leu Arg Gln Phe Lys Leu Ala Lys Ser Trp 805 810 815 Pro Thr
Arg Asn Met Leu Ile Lys Ile Ile Gly Asn Thr Val Gly Ala 820 825 830
Leu Gly Asn Leu Thr Leu Trp Leu Ala Ile Ile Val Phe Ile Phe Ala 835
840 845 Tyr Val Gly Met Gln Leu Phe Gly Lys Ser Ala Lys Glu Cys Val
Cys 850 855 860 Lys Ile Asn Val Glu Cys Lys Leu Pro Arg Trp His Met
Asn Phe Phe 865 870 875 880 Phe His Ser Phe Leu Ile Val Phe Gly Val
Leu Cys Gly Glu Trp Ile 885 890 895 Glu Thr His Trp Asp Cys Met Glu
Val Ala Gly Gln Ile Met Cys Leu 900 905 910 Ile Val Phe Met Leu Val
Lys Val Ile Gly Asn Leu Val Val Leu Asn 915 920 925 Met Phe Leu Ala
Leu Leu Leu Ser Ser Phe Asn Ser Asp Asn Leu Ala 930 935 940 Ala Thr
Asp Asp Gln Asn Glu Met Asn Asn Leu Gln Ile Ala Arg Gly 945 950 955
960 Arg Met Gln Lys Gly Ile Asp Phe Ser Lys Asn Lys Ile Arg Glu Cys
965 970 975 Phe Arg Thr Ala Phe Phe Arg Lys Pro Lys Val Ile Val Ile
Gln Glu 980 985 990 Gly Asn Lys Ile Asp Ser Trp Met Ser Asn Asn Thr
Gly Ile Glu Ile 995 1000 1005 Tyr Lys Glu Leu Asn Tyr Leu Lys Asp
Gly Ala Gly Thr Thr Ser Gly 1010 1015 1020 90 1024 PRT Artificial
Sequence Description of Artificial Sequence Synthetic Sequence 90
Met Ala Gln Ala Leu Leu Val Pro Pro Ala Pro Glu Ser Phe Arg Leu 1 5
10 15 Phe Thr Arg Asp Ser Leu Ala Ala Ile Glu Lys Arg Ala Glu Glu
Glu 20 25 30 Lys Ala Lys Lys Pro Lys Lys Phe Gln Asp Ile Asp Asp
Glu Asn Lys 35 40 45 Pro Gly Pro Asn Ser Asp Leu Glu Ala Gly Lys
His Leu Pro Phe Ile 50 55 60 Tyr Gly Asp Ile Pro Ile Glu Met Val
Ser Glu Pro Leu Glu Asp Lys 65 70 75 80 Asp Pro Tyr Tyr Val Ser Lys
Lys Thr Leu Val Val Leu Asn Lys Gly 85 90 95 Lys Ala Ile Met Arg
Phe Ser Ala Thr Ser Ala Leu Tyr Asn Leu Thr 100 105 110 Pro Leu Asn
Pro Val Arg Lys Gln Ala Ile Lys Ile Leu Val His Ser 115 120 125 Leu
Arg Ser Met Leu Ile Met Cys Thr Ile Leu Ser Asn Cys Val Phe 130 135
140 Met Thr Leu Ser Asn Thr Pro Asp Trp Thr Lys Asn Val Glu Tyr Val
145 150 155 160 Phe Thr Gly Ile Tyr Thr Phe Glu Ser Trp Ile Lys Ile
Leu Ala Arg 165 170 175 Gly Phe Cys Tyr Glu Asp Phe Thr Phe Leu Arg
Asp Pro Ala Asn Trp 180 185 190 Leu Asp Phe Ser Val Ile Val Asp Ala
Tyr Val Thr Glu Phe Val Asp 195 200 205 Leu Glu Asn Val Ser Ala Leu
Arg Thr Phe Arg Phe Leu Arg Ala Leu 210 215 220 Lys Thr Ile Ser Val
Gly Pro Gly Leu Lys Thr Ile Val Gly Ala His 225 230 235 240 Ile Gln
Ser Val Lys Lys Leu Ser Asp Ile Met Ile Leu Thr Val Phe 245 250 255
Cys Leu Ser Lys Phe Ala Leu Ile Gly Leu Gln Leu Phe Leu Gly Asn 260
265 270 Leu Arg Asn Lys Cys Ser Gln Met Pro Pro Ser Asp Ser Ala Phe
Glu 275 280 285 Thr Gln Thr Thr Ser Tyr Phe Asn Gly Thr Met Arg Ser
Asn Gly Thr 290 295 300 Phe Val Asn Val Thr Ser Ser Thr Phe Asn Trp
Lys Asp Tyr Ile Thr 305 310 315 320 Asp Asp Ser His Phe Tyr Val Leu
Asp Val Gln Lys Asp Pro Leu Leu 325 330 335 Cys Gly Asn Trp Ser Asp
Ala Gly Gln Cys Pro Glu Gly Ala Ile Cys 340 345 350 Val Lys Ala Gly
Arg Asn Pro Asp Tyr Gly Tyr Thr Ser Phe Asp Thr 355 360 365 Phe Glu
Trp Ala Phe Leu Ser Leu Phe Arg Leu Phe Thr Gln Asp Tyr 370 375 380
Trp Glu Asn Leu Tyr Gly Leu Thr Leu Arg Ala Ala Gly Lys Thr His 385
390 395 400 Met Ile Phe Phe Val Leu Val Ile Phe Ile Gly Ser Phe Tyr
Leu Val 405 410 415 Asn Leu Ile Lys Ala Val Val Ala Met Ala Tyr Glu
Glu Leu Asn Gln 420 425 430 Ala Thr Leu Glu Glu Ala Glu Met Lys Glu
Ala Glu Phe Gln Gln Met 435 440 445 Leu Asn Gln Leu Lys Lys Gln Gln
Glu Glu Ala Arg Ala Val Ala Ala 450 455 460 Ala Ser Ala Ala Ser Ser
Asp Phe Ser Gly Ile Gly Gly Leu Gly Thr 465 470 475 480 Leu Leu Glu
Ser Ser Ser Glu Ala Ser Val Leu Ser Ser Lys Ser Ala 485 490 495 Lys
Glu Trp Trp Asn Arg Arg Lys Lys Arg Arg Gln Arg Tyr His Leu 500 505
510 Glu Gly Asn His Arg Ala Asp Ala Asp Arg Phe Pro Lys Ser Glu Ser
515 520 525 Glu Glu Ser Val Lys Arg Arg Ser Phe Leu Leu Phe Leu Asp
Gly Asn 530 535 540 Pro Leu Thr Gly Asp Gly Lys Leu Cys Ser Pro His
Gln Ser Leu His 545 550 555 560 Ser Ile Arg Gly Ser Leu Phe Ser Pro
Ile Arg Asn Ser Lys Thr Ser 565 570 575 Ile Phe Ser Lys Arg Gly Arg
Ala Lys Asp Val Gly Ser Leu Asn Asp 580 585 590 Phe Ala Asp Asp Glu
His Ser Met Phe Glu Asp Ser Glu Ser Arg Arg 595 600 605 Asp Asn Leu
Phe Val Pro His Arg Pro Gly Glu Gln Arg Asn Ser Asn 610 615 620 Gly
Thr Thr Thr Glu Arg Glu Val Arg Lys Arg Arg Leu Ser Ser Ser 625 630
635 640 Gln Ile Ser Met Glu Met Leu Glu Asp Thr Ser Gly Arg Gln Arg
Ser 645 650 655 Met Ser Ile Val Ser Ile Leu Thr Asn Thr Met Glu Glu
Trp Glu Glu 660 665 670 Ser Arg Gln Lys Cys Pro Pro Tyr Trp Tyr Arg
Phe Ala Asn Val Phe 675 680 685 Leu Ala Trp Asp Cys Cys Asp Ala Trp
Leu Lys Asp Lys His Leu Val 690 695 700 Asn Leu Ile Val Met Glu Pro
Phe Val Asp Leu Ala Ile Thr Ile Phe 705 710 715 720 Ile Val Leu Asn
Thr Leu Phe Met Ala Gly Glu His Tyr Pro Met Thr 725 730 735 Gln Gln
Phe His Ser Val Leu Thr Val Gly Asn Leu Val Ile Thr Gly 740 745 750
Ile Phe Thr Ala Glu Met Val Lys Lys Ile Ile Ala Met Asp Pro Tyr 755
760 765 Tyr Leu Phe Gln Glu Gly Trp Asn Ile Phe Asp Met Ile Ile Val
Ser 770 775 780 Leu Ser Leu Met Glu Asn Gly Leu Ala Asn Val Glu Gly
Leu Ser Gln 785 790 795 800 Leu Arg Ser Phe Arg Leu Leu Arg Val Arg
Lys Leu Ala Lys Ser Trp 805 810 815 Pro Thr Leu Ser Met Leu Ile Lys
Ile Ile Gly Asn Ser Thr Gly Ala 820 825 830 Leu Gly Asn Leu Thr Leu
Val Val Ala Ile Ile Val Phe Ile Phe Ala 835 840 845 Val Trp Gly Met
Gln Leu Phe Gly Lys Ser Tyr Tyr Glu Cys Val Cys 850 855 860 Lys Ile
Asn Val Asp Ala Lys Leu Pro Arg Trp His Met Asn Asp Asp 865 870 875
880 Phe His Ser Phe Leu Ile Val Phe Arg Glu Leu Cys Gly Glu Trp Ile
885 890 895 Glu Thr Met Phe Asp Cys Met Glu Val Ala Gly Gln Thr Gly
Cys Leu 900 905 910 Ile Val Phe Met Leu Val Met His Ile Gly Asn Leu
Val Val Leu Asn 915 920 925 Leu Ile Leu Ala Leu Leu Leu Ser Ser Phe
Ser Lys Asp Asn Leu Ala 930 935 940 Ala Thr Asp Asp Asp Leu Glu Met
Asn Asn Leu Gln Ile Ala Val Met 945 950 955 960 Arg Met Gln Lys Gly
Ile Asp Phe Val Asn Asn Lys Ile Arg Glu Cys 965 970 975 Phe Arg Lys
Gln Phe Phe Arg Lys Pro Lys Val Ile Glu Arg Gln Glu 980 985 990 Gly
Asn Lys Ile Asp Ser Cys Ser Ser Asn Asn Thr Gly Ile Glu Ile 995
1000 1005 Ser Thr Glu Leu Asn Tyr Leu Lys Asp Gly Asn Val Thr Thr
Ser Gly 1010 1015 1020 91 749 PRT Artificial Sequence Description
of Artificial Sequence Synthetic Sequence 91 Met Ala His Arg Lys
Leu Glu Ser Val Gly Ser Gly Met Leu Asp His 1 5 10 15 Arg Val Arg
Pro Gly Pro Val Pro His Ser Gln Glu Pro Glu Ser Glu 20 25 30 Asp
Met Glu Leu Pro Leu Glu Gly Tyr Val Pro Glu Gly Leu Glu Leu 35 40
45 Ala Ala Leu Arg Pro Glu Ser Pro Ala Pro Glu Glu Gln Glu Cys His
50 55 60 Asn His Ser Pro Asp Gly Asp Ser Ser Ser Asp Tyr Val Asn
Asn Thr 65 70 75 80 Ser Glu Glu Glu Asp Tyr Asp Glu Gly Leu Pro Glu
Glu Glu Glu Gly 85 90 95 Ile Thr Tyr Tyr Ile Arg Tyr Cys Pro Glu
Asp Asp Ser Tyr Leu Glu 100 105 110 Gly Met Asp Cys Asn Gly Glu Glu
Tyr Leu Ala His Ser Ala His Pro 115 120 125 Val Asp Thr Asp Glu Cys
Gln Glu Ala Val Glu Glu Trp Thr Asp Ser 130 135 140 Ala Gly Pro His
Pro His Gly His Glu Ala Glu Gly Ser Gln Asp Tyr 145 150 155 160 Pro
Asp Gly Gln Leu Pro Ile Pro Glu Asp Glu Pro Ser Val Leu Glu 165 170
175 Ala His Asp Gln Glu Glu Asp Gly His Tyr Cys Ala Ser Lys Glu Gly
180 185 190 Tyr Gln Asp Tyr Tyr Pro Glu Glu Ala Asn Gly Asn Thr Gly
Ala Ser 195 200 205 Pro Tyr Arg Leu Arg Arg Gly Asp Gly Asp Leu Glu
Asp Gln Glu Glu 210 215 220 Asp Ile Asp Gln Ile Val Ala Glu Ile Lys
Met Ser Leu Ser Met Thr 225 230 235 240 Ser Ile Thr Ser Ala Ser Glu
Ala Ser Pro Glu His Gly Pro Glu Pro 245 250 255 Gly Pro Glu Asp Ser
Val Glu Ala Cys Pro Pro Ile Lys Ala Ser Cys 260 265 270 Ser Pro Ser
Arg His Glu Ala Arg Pro Lys Ser Leu Asn Leu Leu Pro 275 280 285 Glu
Ala Lys His Pro Gly Asp Pro Gln Arg Gly Phe Lys Pro Lys Thr 290 295
300 Arg Thr Pro Glu Glu Arg Leu Lys Trp Pro His Glu Gln Val Cys Asn
305 310 315 320 Gly Leu Glu Gln Pro Arg Lys Gln Gln Arg Ser Asp Leu
Asn Gly Pro 325 330 335 Val Asp Asn Asn Asn Ile Pro Glu Thr Lys Lys
Val Ala Ser Phe Pro 340 345 350 Ser Phe Val Ala Val Pro Gly Pro Cys
Glu Pro Glu Asp Leu Ile Asp 355 360 365 Gly Ile Ile Phe Ala Ala Asn
Tyr Leu Gly Ser Thr Gln Leu Leu Ser 370 375 380 Glu Arg Asn Pro Ser
Lys Asn Ile Arg Met Met Gln Ala Gln Glu Ala 385 390 395 400 Val Ser
Arg Val Lys Arg Met Gln Lys Ala Ala Lys Ile Lys Lys Lys 405 410 415
Ala Asn Ser Glu Gly Asp Ala Gln Thr Leu Thr Glu Val Asp Leu Phe 420
425 430 Ile Ser Thr Gln Arg Ile Lys Val Leu Asn Ala Asp Thr Gln Glu
Thr 435 440 445 Met Met Asp His Ala Leu Arg Thr Ile Ser Tyr Ile Ala
Asp Ile Gly 450 455 460 Asn Ile Val Val Leu Met Ala Arg Arg Arg Met
Pro Arg Ser Ala Ser 465 470 475 480 Gln Asp Cys Ile Glu Thr Thr Pro
Gly Ala Gln Glu Gly Lys Lys Gln 485 490 495 Tyr Lys Met Ile Cys His
Val Phe Glu Ser Glu Asp Ala Gln Leu Ile 500 505 510 Ala Gln Ser Ile
Gly Gln Ala Phe Ser Val Ala Tyr Gln Glu Phe Leu 515 520 525 Arg Ala
Asn Gly Ile Asn Pro Glu Asp Leu Ser Gln Lys Glu Tyr Ser 530 535 540
Asp Ile Ile Asn Thr Gln Glu Met Tyr Asn Asp Asp Leu Ile His Phe 545
550 555 560 Ser Asn Ser Glu Asn Cys Lys Glu Leu Gln Leu Glu Lys His
Lys Gly 565 570
575 Glu Ile Leu Gly Val Val Val Val Glu Ser Gly Trp Gly Ser Ile Leu
580 585 590 Pro Thr Val Ile Leu Ala Asn Met Met Asn Gly Gly Pro Ala
Ala Arg 595 600 605 Ser Gly Lys Leu Ser Ile Gly Asp Gln Ile Met Ser
Ile Asn Gly Thr 610 615 620 Ser Leu Val Gly Leu Pro Leu Ala Thr Cys
Gln Gly Ile Ile Lys Gly 625 630 635 640 Leu Lys Asn Gln Thr Gln Val
Lys Leu Asn Ile Val Ser Cys Pro Pro 645 650 655 Val Thr Thr Val Leu
Ile Lys Arg Pro Asp Leu Lys Tyr Gln Leu Gly 660 665 670 Phe Ser Val
Gln Asn Gly Ile Ile Cys Ser Leu Met Arg Gly Gly Ile 675 680 685 Ala
Glu Arg Gly Gly Val Arg Val Gly His Arg Ile Ile Glu Ile Asn 690 695
700 Gly Gln Ser Val Val Ala Thr Ala His Glu Lys Ile Val Gln Ala Leu
705 710 715 720 Ser Asn Ser Val Gly Glu Ile His Met Lys Thr Met Pro
Ala Ala Met 725 730 735 Phe Arg Leu Leu Thr Gly Gln Glu Thr Pro Leu
Tyr Ile 740 745 92 749 PRT Artificial Sequence Description of
Artificial Sequence Synthetic Sequence 92 Met Asp His Arg Lys Leu
Glu Ser Val Gly Ser Glu Met Leu Asp His 1 5 10 15 Arg Val Arg Pro
Gly Phe Val Pro His Ser Gln Glu Pro Glu Ser Gly 20 25 30 Asp Met
Glu Leu Pro Leu Glu Gly Tyr His Pro Glu Gly Leu Glu Leu 35 40 45
Ala Ala Leu Ile Pro Glu Ser Pro Ala Pro Glu Glu Gln Lys Cys His 50
55 60 Asn His Ser Pro Asp Gly Asp Leu Ser Ser Asp Tyr Val Asn Asn
Thr 65 70 75 80 Ser Met Glu Glu Asp Tyr Asp Glu Gly Leu Pro Asn Glu
Glu Glu Gly 85 90 95 Ile Thr Tyr Tyr Ile Gln Tyr Cys Pro Glu Asp
Asp Ser Tyr Leu Arg 100 105 110 Gly Met Asp Cys Asn Gly Glu Glu Tyr
Ser Ala His Ser Ala His Pro 115 120 125 Val Asp Thr Thr Glu Cys Gln
Glu Ala Val Glu Glu Trp Val Asp Ser 130 135 140 Ala Gly Pro His Pro
His Gly Trp Glu Ala Glu Gly Ser Gln Asp Tyr 145 150 155 160 Pro Tyr
Gly Gln Leu Pro Ile Pro Glu Asp Glu Ala Ser Val Leu Glu 165 170 175
Ala His Asp Gln Glu Asp Asp Gly His Tyr Cys Ala Ser Lys Glu Glu 180
185 190 Tyr Gln Asp Tyr Tyr Pro Glu Glu Ala Phe Gly Asn Thr Gly Ala
Ser 195 200 205 Pro Tyr Arg Gly Arg Arg Gly Asp Gly Asp Leu Glu Asp
His Glu Glu 210 215 220 Asp Ile Asp Gln Ile Val Ala Ile Ile Lys Met
Ser Leu Ser Met Thr 225 230 235 240 Ser Lys Thr Ser Ala Ser Glu Ala
Ser Pro Glu Leu Gly Pro Glu Pro 245 250 255 Gly Pro Glu Asp Ser Met
Glu Ala Cys Pro Pro Ile Lys Ala Ser Asn 260 265 270 Ser Pro Ser Arg
His Glu Ala Arg Pro Gln Ser Leu Asn Leu Leu Pro 275 280 285 Glu Ala
Lys Arg Pro Gly Asp Pro Gln Arg Gly Phe Lys Ser Lys Thr 290 295 300
Arg Thr Pro Glu Glu Arg Leu Thr Trp Pro His Glu Gln Val Cys Asn 305
310 315 320 Gly Val Glu Gln Pro Arg Lys Gln Gln Arg Ser Trp Leu Asn
Gly Pro 325 330 335 Val Asp Asn Asn Asn Tyr Pro Glu Thr Lys Lys Val
Ala Ser Phe Ala 340 345 350 Ser Phe Val Ala Val Pro Gly Pro Cys Asp
Pro Glu Asp Leu Ile Asp 355 360 365 Gly Ile Ile Glu Ala Ala Asn Tyr
Leu Gly Ser Thr Gln Phe Leu Ser 370 375 380 Glu Arg Asn Pro Ser Lys
Asn Gly Arg Met Met Gln Ala Gln Glu Ala 385 390 395 400 Val His Arg
Val Lys Arg Met Gln Lys Ala Ala Ile Ile Lys Lys Lys 405 410 415 Ala
Asn Ser Glu Gly Lys Ala Gln Thr Leu Thr Glu Val Asp Leu Leu 420 425
430 Ile Ser Thr Gln Arg Ile Lys Val Leu Met Ala Asp Thr Gln Glu Thr
435 440 445 Met Met Asp Asn Ala Leu Arg Thr Ile Ser Tyr Ile Ala Gln
Ile Gly 450 455 460 Asn Ile Val Val Leu Met Ala Ser Arg Arg Met Pro
Arg Ser Ala Ser 465 470 475 480 Gln Thr Cys Ile Glu Thr Thr Pro Gly
Ala Gln Val Gly Lys Lys Gln 485 490 495 Tyr Lys Met Ile Cys Trp Val
Phe Glu Ser Glu Asp Ala Gln Leu Tyr 500 505 510 Ala Gln Ser Ile Gly
Gln Ala Phe Ser Ala Ala Tyr Gln Glu Phe Leu 515 520 525 Arg Ala Asn
Asp Ile Asn Pro Glu Asp Leu Ser Gln Lys Phe Tyr Ser 530 535 540 Asp
Ile Ile Asn Thr Gln Glu Gly Tyr Asn Asp Asp Leu Ile His Phe 545 550
555 560 Ser His Ser Glu Asn Cys Lys Glu Leu Gln Leu Ile Lys His Lys
Gly 565 570 575 Glu Ile Leu Gly Val Lys Val Val Glu Ser Gly Trp Gly
Ser Ile Met 580 585 590 Pro Thr Val Ile Leu Ala Asn Met Met Gln Gly
Gly Pro Ala Ala Arg 595 600 605 Ser Gly Lys Arg Ser Ile Gly Asp Gln
Ile Met Ser Ile Ser Gly Thr 610 615 620 Ser Leu Val Gly Leu Pro Leu
Thr Thr Cys Gln Gly Ile Ile Lys Gly 625 630 635 640 Leu Val Asn Gln
Thr Gln Val Lys Leu Asn Ile Trp Ser Cys Pro Pro 645 650 655 Val Thr
Thr Val Leu Tyr Lys Arg Pro Asp Leu Lys Tyr Gln Leu Ala 660 665 670
Phe Ser Val Gln Asn Gly Ile Ile Cys Asp Leu Met Arg Gly Gly Ile 675
680 685 Ala Glu Arg Glu Gly Val Arg Val Gly His Arg Ile Ile Phe Ile
Asn 690 695 700 Gly Gln Ser Val Val Ala Thr His His Glu Lys Ile Val
Gln Ala Leu 705 710 715 720 Ser Ile Ser Val Gly Glu Ile His Met Lys
Thr Lys Pro Ala Ala Met 725 730 735 Phe Arg Leu Leu Thr Leu Gln Glu
Thr Pro Leu Tyr Ile 740 745 93 749 PRT Artificial Sequence
Description of Artificial Sequence Synthetic Sequence 93 Met Ala
Ala Arg Lys Leu Glu Ser Val Gly Ser Gly Asp Leu Asp His 1 5 10 15
Arg Val Arg Pro Gly Pro Glu Pro His Ser Gln Glu Pro Glu Ser Glu 20
25 30 Phe Met Glu Leu Pro Leu Glu Gly Tyr Val Gly Glu Gly Leu Glu
Leu 35 40 45 Ala Ala Leu Arg His Glu Ser Pro Ala Pro Glu Glu Gln
Glu Ile His 50 55 60 Asn His Ser Pro Asp Gly Asp Ser Lys Ser Asp
Tyr Val Asn Asn Thr 65 70 75 80 Ser Glu Leu Glu Asp Tyr Asp Glu Gly
Leu Pro Glu Met Glu Glu Gly 85 90 95 Ile Thr Tyr Tyr Ile Arg Asn
Cys Pro Glu Asp Asp Ser Tyr Leu Glu 100 105 110 Gln Met Asp Cys Asn
Gly Glu Glu Tyr Leu Arg His Ser Ala His Pro 115 120 125 Val Asp Thr
Asp Ser Cys Gln Glu Ala Val Glu Glu Trp Thr Thr Ser 130 135 140 Ala
Gly Pro His Pro His Gly His Val Ala Glu Gly Ser Gln Asp Tyr 145 150
155 160 Pro Asp Trp Gln Leu Pro Ile Pro Glu Asp Glu Pro Tyr Val Leu
Glu 165 170 175 Ala His Asp Gln Glu Glu Ala Gly His Tyr Cys Ala Ser
Lys Glu Gly 180 185 190 Asp Gln Asp Tyr Tyr Pro Glu Glu Ala Asn Glu
Asn Thr Gly Ala Ser 195 200 205 Pro Tyr Arg Leu Phe Arg Gly Asp Gly
Asp Leu Glu Asp Gln Gly Glu 210 215 220 Asp Ile Asp Gln Ile Val Ala
Glu His Lys Met Ser Leu Ser Met Thr 225 230 235 240 Ser Ile Ile Ser
Ala Ser Glu Ala Ser Pro Glu His Lys Pro Glu Pro 245 250 255 Gly Pro
Glu Asp Ser Val Leu Ala Cys Pro Pro Ile Lys Ala Ser Cys 260 265 270
Met Pro Ser Arg His Glu Ala Arg Pro Lys Asn Leu Asn Leu Leu Pro 275
280 285 Glu Ala Lys His Gln Gly Asp Pro Gln Arg Gly Phe Lys Pro Arg
Thr 290 295 300 Arg Thr Pro Glu Glu Arg Leu Lys Ser Pro His Glu Gln
Val Cys Asn 305 310 315 320 Gly Leu Thr Gln Pro Arg Lys Gln Gln Arg
Ser Asp Val Asn Gly Pro 325 330 335 Val Asp Asn Asn Asn Ile Trp Glu
Thr Lys Lys Val Ala Ser Phe Pro 340 345 350 Tyr Phe Val Ala Val Pro
Gly Pro Cys Glu Ala Glu Asp Leu Ile Asp 355 360 365 Gly Ile Ile Phe
Asp Ala Asn Tyr Leu Gly Ser Thr Gln Leu Glu Ser 370 375 380 Glu Arg
Asn Pro Ser Lys Asn Ile Phe Met Met Gln Ala Gln Glu Ala 385 390 395
400 Val Ser Gly Val Lys Arg Met Gln Lys Ala Ala Lys His Lys Lys Lys
405 410 415 Ala Asn Ser Glu Gly Asp Ile Gln Thr Leu Thr Glu Val Asp
Leu Phe 420 425 430 Lys Ser Thr Gln Arg Ile Lys Val Leu Asn Leu Asp
Thr Gln Glu Thr 435 440 445 Met Met Asp His Met Leu Arg Thr Ile Ser
Tyr Ile Ala Asp Asn Gly 450 455 460 Asn Ile Val Val Leu Met Ala Arg
Gln Arg Met Pro Arg Ser Ala Ser 465 470 475 480 Gln Asp Arg Ile Glu
Thr Thr Pro Gly Ala Gln Glu Ser Lys Lys Gln 485 490 495 Tyr Lys Met
Ile Cys His Thr Phe Glu Ser Glu Asp Ala Gln Leu Ile 500 505 510 Val
Gln Ser Ile Gly Gln Ala Phe Ser Val Trp Tyr Gln Glu Phe Leu 515 520
525 Arg Ala Asn Gly Tyr Asn Pro Glu Asp Leu Ser Gln Lys Glu Ala Ser
530 535 540 Asp Ile Ile Asn Thr Gln Glu Met Asp Asn Asp Asp Leu Ile
His Phe 545 550 555 560 Ser Asn Glu Glu Asn Cys Lys Glu Leu Gln Leu
Glu Phe His Lys Gly 565 570 575 Glu Ile Leu Gly Val Val Gly Val Glu
Ser Gly Trp Gly Ser Ile Leu 580 585 590 His Thr Val Ile Leu Ala Asn
Met Met Asn Ile Gly Pro Ala Ala Arg 595 600 605 Ser Gly Lys Leu Lys
Ile Gly Asp Gln Ile Met Ser Ile Asn Leu Thr 610 615 620 Ser Leu Val
Gly Leu Pro Leu Ala Met Cys Gln Gly Ile Ile Lys Gly 625 630 635 640
Leu Lys Gln Gln Thr Gln Val Lys Leu Asn Ile Val Arg Cys Pro Pro 645
650 655 Val Thr Thr Val Leu Ile Ser Arg Pro Asp Leu Lys Tyr Gln Leu
Gly 660 665 670 Thr Ser Val Gln Asn Gly Ile Ile Cys Ser Val Met Arg
Gly Gly Ile 675 680 685 Ala Glu Arg Gly Trp Val Arg Val Gly His Arg
Ile Ile Glu Tyr Asn 690 695 700 Gly Gln Ser Val Val Ala Thr Ala Ala
Glu Lys Ile Val Gln Ala Leu 705 710 715 720 Ser Asn Asp Val Gly Glu
Ile His Met Lys Thr Met Glu Ala Ala Met 725 730 735 Phe Arg Leu Leu
Thr Gly Phe Glu Thr Pro Leu Tyr Ile 740 745 94 749 PRT Artificial
Sequence Description of Artificial Sequence Synthetic Sequence 94
Met Ala His Ala Lys Leu Glu Ser Val Gly Ser Gly Met Asp Asp His 1 5
10 15 Arg Val Arg Pro Gly Pro Val Glu His Ser Gln Glu Pro Glu Ser
Glu 20 25 30 Asp Phe Glu Leu Pro Leu Glu Gly Tyr Val Pro Gly Gly
Leu Glu Leu 35 40 45 Ala Ala Leu Arg Pro His Ser Pro Ala Pro Glu
Glu Gln Glu Cys Ile 50 55 60 Asn His Ser Pro Asp Gly Asp Ser Ser
Lys Asp Tyr Val Asn Asn Thr 65 70 75 80 Ser Glu Glu Leu Asp Tyr Asp
Glu Gly Leu Pro Glu Glu Met Glu Gly 85 90 95 Ile Thr Tyr Tyr Ile
Arg Tyr Asn Pro Glu Asp Asp Ser Tyr Leu Glu 100 105 110 Gly Gln Asp
Cys Asn Gly Glu Glu Tyr Leu Ala Arg Ser Ala His Pro 115 120 125 Val
Asp Thr Asp Glu Ser Gln Glu Ala Val Glu Glu Trp Thr Asp Thr 130 135
140 Ala Gly Pro His Pro His Gly His Glu Val Glu Gly Ser Gln Asp Tyr
145 150 155 160 Pro Asp Gly Trp Leu Pro Ile Pro Glu Asp Glu Pro Ser
Tyr Leu Glu 165 170 175 Ala His Asp Gln Glu Glu Asp Ala His Tyr Cys
Ala Ser Lys Glu Gly 180 185 190 Tyr Asp Asp Tyr Tyr Pro Glu Glu Ala
Asn Gly Glu Thr Gly Ala Ser 195 200 205 Pro Tyr Arg Leu Arg Phe Gly
Asp Gly Asp Leu Glu Asp Gln Glu Gly 210 215 220 Asp Ile Asp Gln Ile
Val Ala Glu Ile His Met Ser Leu Ser Met Thr 225 230 235 240 Ser Ile
Thr Ile Ala Ser Glu Ala Ser Pro Glu His Gly Lys Glu Pro 245 250 255
Gly Pro Glu Asp Ser Val Glu Leu Cys Pro Pro Ile Lys Ala Ser Cys 260
265 270 Ser Met Ser Arg His Glu Ala Arg Pro Lys Ser Asn Asn Leu Leu
Pro 275 280 285 Glu Ala Lys His Pro Gln Asp Pro Gln Arg Gly Phe Lys
Pro Lys Arg 290 295 300 Arg Thr Pro Glu Glu Arg Leu Lys Trp Ser His
Glu Gln Val Cys Asn 305 310 315 320 Gly Leu Glu Thr Pro Arg Lys Gln
Gln Arg Ser Asp Leu Val Gly Pro 325 330 335 Val Asp Asn Asn Asn Ile
Pro Trp Thr Lys Lys Val Ala Ser Phe Pro 340 345 350 Ser Tyr Val Ala
Val Pro Gly Pro Cys Glu Pro Ala Asp Leu Ile Asp 355 360 365 Gly Ile
Ile Phe Ala Asp Asn Tyr Leu Gly Ser Thr Gln Leu Leu Glu 370 375 380
Glu Arg Asn Pro Ser Lys Asn Ile Arg Phe Met Gln Ala Gln Glu Ala 385
390 395 400 Val Ser Arg Gly Lys Arg Met Gln Lys Ala Ala Lys Ile His
Lys Lys 405 410 415 Ala Asn Ser Glu Gly Asp Ala Ile Thr Leu Thr Glu
Val Asp Leu Phe 420 425 430 Ile Lys Thr Gln Arg Ile Lys Val Leu Asn
Ala Leu Thr Gln Glu Thr 435 440 445 Met Met Asp His Ala Met Arg Thr
Ile Ser Tyr Ile Ala Asp Ile Asn 450 455 460 Asn Ile Val Val Leu Met
Ala Arg Arg Gln Met Pro Arg Ser Ala Ser 465 470 475 480 Gln Asp Cys
Arg Glu Thr Thr Pro Gly Ala Gln Glu Gly Ser Lys Gln 485 490 495 Tyr
Lys Met Ile Cys His Val Thr Glu Ser Glu Asp Ala Gln Leu Ile 500 505
510 Ala Val Ser Ile Gly Gln Ala Phe Ser Val Ala Trp Gln Glu Phe Leu
515 520 525 Arg Ala Asn Gly Ile Tyr Pro Glu Asp Leu Ser Gln Lys Glu
Tyr Ala 530 535 540 Asp Ile Ile Asn Thr Gln Glu Met Tyr Asp Asp Asp
Leu Ile His Phe 545 550 555 560 Ser Asn Ser Phe Asn Cys Lys Glu Leu
Gln Leu Glu Lys Gly Lys Gly 565 570 575 Glu Ile Leu Gly Val Val Val
His Glu Ser Gly Trp Gly Ser Ile Leu 580 585 590 Pro Ile Val Ile Leu
Ala Asn Met Met Asn Gly Lys Pro Ala Ala Arg 595 600 605 Ser Gly Lys
Leu Ser Leu Gly Asp Gln Ile Met Ser Ile Asn Gly Met 610 615 620 Ser
Leu Val Gly Leu Pro Leu Ala Thr Asn Gln Gly Ile Ile Lys Gly 625 630
635 640 Leu Lys Asn Arg Thr Gln Val Lys Leu Asn Ile Val Ser Ser Pro
Pro 645 650 655 Val Thr Thr Val Leu Ile Lys Thr Pro Asp Leu Lys Tyr
Gln Leu Gly 660 665 670 Phe Val Val Gln Asn Gly Ile Ile Cys Ser Leu
Trp Arg Gly Gly Ile 675 680 685 Ala Glu Arg Gly Gly Tyr Arg Val Gly
His Arg Ile Ile Glu Ile Ala 690 695 700 Gly Gln Ser Val Val Ala Thr
Ala His Asp Lys Ile Val Gln Ala Leu 705 710 715 720 Ser Asn Ser Glu
Gly Glu Ile His Met Lys Thr Met Pro Phe Ala Met 725 730 735 Phe Arg
Leu Leu Thr Gly Gln
Gly Thr Pro Leu Tyr Ile 740 745 95 749 PRT Artificial Sequence
Description of Artificial Sequence Synthetic Sequence 95 Met Ala
His Arg Ala Leu Glu Ser Val Gly Ser Gly Met Leu Glu His 1 5 10 15
Arg Val Arg Pro Gly Pro Val Pro Phe Ser Gln Glu Pro Glu Ser Glu 20
25 30 Asp Met Gly Leu Pro Leu Glu Gly Tyr Val Pro Glu His Leu Glu
Leu 35 40 45 Ala Ala Leu Arg Pro Glu Ile Pro Ala Pro Glu Glu Gln
Glu Cys His 50 55 60 Lys His Ser Pro Asp Gly Asp Ser Ser Ser Leu
Tyr Val Asn Asn Thr 65 70 75 80 Ser Glu Glu Glu Met Tyr Asp Glu Gly
Leu Pro Glu Glu Glu Asn Gly 85 90 95 Ile Thr Tyr Tyr Ile Arg Tyr
Cys Gln Glu Asp Asp Ser Tyr Leu Glu 100 105 110 Gly Met Arg Cys Asn
Gly Glu Glu Tyr Leu Ala His Thr Ala His Pro 115 120 125 Val Asp Thr
Asp Glu Cys Val Glu Ala Val Glu Glu Trp Thr Asp Ser 130 135 140 Trp
Gly Pro His Pro His Gly His Glu Ala Tyr Gly Ser Gln Asp Tyr 145 150
155 160 Pro Asp Gly Gln Ala Pro Ile Pro Glu Asp Glu Pro Ser Val Asp
Glu 165 170 175 Ala His Asp Gln Glu Glu Asp Gly Glu Tyr Cys Ala Ser
Lys Glu Gly 180 185 190 Tyr Gln Phe Tyr Tyr Pro Glu Glu Ala Asn Gly
Asn Gly Gly Ala Ser 195 200 205 Pro Tyr Arg Leu Arg Arg His Asp Gly
Asp Leu Glu Asp Gln Glu Glu 210 215 220 Ile Ile Asp Gln Ile Val Ala
Glu Ile Lys Lys Ser Leu Ser Met Thr 225 230 235 240 Ser Ile Thr Ser
Leu Ser Glu Ala Ser Pro Glu His Gly Pro Met Pro 245 250 255 Gly Pro
Glu Asp Ser Val Glu Ala Asn Pro Pro Ile Lys Ala Ser Cys 260 265 270
Ser Pro Gln Arg His Glu Ala Arg Pro Lys Ser Leu Arg Leu Leu Pro 275
280 285 Glu Ala Lys His Pro Gly Ser Pro Gln Arg Gly Phe Lys Pro Lys
Thr 290 295 300 Thr Thr Pro Glu Glu Arg Leu Lys Trp Pro Val Glu Gln
Val Cys Asn 305 310 315 320 Gly Leu Glu Gln Trp Arg Lys Gln Gln Arg
Ser Asp Leu Asn Tyr Pro 325 330 335 Val Asp Asn Asn Asn Ile Pro Glu
Ala Lys Lys Val Ala Ser Phe Pro 340 345 350 Ser Phe Asp Ala Val Pro
Gly Pro Cys Glu Pro Glu Glu Leu Ile Asp 355 360 365 Gly Ile Ile Phe
Ala Ala Phe Tyr Leu Gly Ser Thr Gln Leu Leu Ser 370 375 380 Gly Arg
Asn Pro Ser Lys Asn Ile Arg Met His Gln Ala Gln Glu Ala 385 390 395
400 Val Ser Arg Val Ile Arg Met Gln Lys Ala Ala Lys Ile Lys Leu Lys
405 410 415 Ala Asn Ser Glu Gly Asp Ala Gln Met Leu Thr Glu Val Asp
Leu Phe 420 425 430 Ile Ser Asn Gln Arg Ile Lys Val Leu Asn Ala Asp
Gln Gln Glu Thr 435 440 445 Met Met Asp His Ala Leu Ser Thr Ile Ser
Tyr Ile Ala Asp Ile Gly 450 455 460 Thr Ile Val Val Leu Met Ala Arg
Arg Arg Val Pro Arg Ser Ala Ser 465 470 475 480 Gln Asp Cys Ile Trp
Thr Thr Pro Gly Ala Gln Glu Gly Lys Tyr Gln 485 490 495 Tyr Lys Met
Ile Cys His Val Phe Ala Ser Glu Asp Ala Gln Leu Ile 500 505 510 Ala
Gln Asp Ile Gly Gln Ala Phe Ser Val Ala Tyr Glu Glu Phe Leu 515 520
525 Arg Ala Asn Gly Ile Asn Phe Glu Asp Leu Ser Gln Lys Glu Tyr Ser
530 535 540 Gly Ile Ile Asn Thr Gln Glu Met Tyr Asn His Asp Leu Ile
His Phe 545 550 555 560 Ser Asn Ser Glu Ile Cys Lys Glu Leu Gln Leu
Glu Lys His Leu Gly 565 570 575 Glu Ile Leu Gly Val Val Val Val Met
Ser Gly Trp Gly Ser Ile Leu 580 585 590 Pro Thr Asn Ile Leu Ala Asn
Met Met Asn Gly Gly Gln Ala Ala Arg 595 600 605 Ser Gly Lys Leu Ser
Ile Arg Asp Gln Ile Met Ser Ile Asn Gly Thr 610 615 620 Thr Leu Val
Gly Leu Pro Leu Ala Thr Cys Val Gly Ile Ile Lys Gly 625 630 635 640
Leu Lys Asn Gln Trp Gln Val Lys Leu Asn Ile Val Ser Cys Tyr Pro 645
650 655 Val Thr Thr Val Leu Ile Lys Arg Ala Asp Leu Lys Tyr Gln Leu
Gly 660 665 670 Phe Ser Asp Gln Asn Gly Ile Ile Cys Ser Leu Met Glu
Gly Gly Ile 675 680 685 Ala Glu Arg Gly Gly Val Phe Val Gly His Arg
Ile Ile Glu Ile Asn 690 695 700 His Gln Ser Val Val Ala Thr Ala His
Glu Ile Ile Val Gln Ala Leu 705 710 715 720 Ser Asn Ser Val Lys Glu
Ile His Met Lys Thr Met Pro Ala Leu Met 725 730 735 Phe Arg Leu Leu
Thr Gly Gln Glu Met Pro Leu Tyr Ile 740 745 96 749 PRT Artificial
Sequence Description of Artificial Sequence Synthetic Sequence 96
Met Ala His Arg Lys Ala Glu Ser Val Gly Ser Gly Met Leu Asp Asp 1 5
10 15 Arg Val Arg Pro Gly Pro Val Pro His Glu Gln Glu Pro Glu Ser
Glu 20 25 30 Asp Met Glu Phe Pro Leu Glu Gly Tyr Val Pro Glu Gly
Gly Glu Leu 35 40 45 Ala Ala Leu Arg Pro Glu Ser His Ala Pro Glu
Glu Gln Glu Cys His 50 55 60 Asn Ile Ser Pro Asp Gly Asp Ser Ser
Ser Asp Lys Val Asn Asn Thr 65 70 75 80 Ser Glu Glu Glu Asp Leu Asp
Glu Gly Leu Pro Glu Glu Glu Glu Met 85 90 95 Ile Thr Tyr Tyr Ile
Arg Tyr Cys Pro Asn Asp Asp Ser Tyr Leu Glu 100 105 110 Gly Met Asp
Gln Asn Gly Glu Glu Tyr Leu Ala His Ser Arg His Pro 115 120 125 Val
Asp Thr Asp Glu Cys Gln Ser Ala Val Glu Glu Trp Thr Asp Ser 130 135
140 Ala Thr Pro His Pro His Gly His Glu Ala Glu Val Ser Gln Asp Tyr
145 150 155 160 Pro Asp Gly Gln Leu Trp Ile Pro Glu Asp Glu Pro Ser
Val Leu Tyr 165 170 175 Ala His Asp Gln Glu Glu Asp Gly His Ala Cys
Ala Ser Lys Glu Gly 180 185 190 Tyr Gln Asp Asp Tyr Pro Glu Glu Ala
Asn Gly Asn Thr Glu Ala Ser 195 200 205 Pro Tyr Arg Leu Arg Arg Gly
Phe Gly Asp Leu Glu Asp Gln Glu Glu 210 215 220 Asp Gly Asp Gln Ile
Val Ala Glu Ile Lys Met His Leu Ser Met Thr 225 230 235 240 Ser Ile
Thr Ser Ala Ile Glu Ala Ser Pro Glu His Gly Pro Glu Lys 245 250 255
Gly Pro Glu Asp Ser Val Glu Ala Cys Leu Pro Ile Lys Ala Ser Cys 260
265 270 Ser Pro Ser Met His Glu Ala Arg Pro Lys Ser Leu Asn Asn Leu
Pro 275 280 285 Glu Ala Lys His Pro Gly Asp Gln Gln Arg Gly Phe Lys
Pro Lys Thr 290 295 300 Arg Arg Pro Glu Glu Arg Leu Lys Trp Pro His
Ser Gln Val Cys Asn 305 310 315 320 Gly Leu Glu Gln Pro Thr Lys Gln
Gln Arg Ser Asp Leu Asn Gly Val 325 330 335 Val Asp Asn Asn Asn Ile
Pro Glu Thr Trp Lys Val Ala Ser Phe Pro 340 345 350 Ser Phe Val Tyr
Val Pro Gly Pro Cys Glu Pro Glu Asp Ala Ile Asp 355 360 365 Gly Ile
Ile Phe Ala Ala Asn Asp Leu Gly Ser Thr Gln Leu Leu Ser 370 375 380
Glu Glu Asn Pro Ser Lys Asn Ile Arg Met Met Phe Ala Gln Glu Ala 385
390 395 400 Val Ser Arg Val Lys Gly Met Gln Lys Ala Ala Lys Ile Lys
Lys His 405 410 415 Ala Asn Ser Glu Gly Asp Ala Gln Thr Ile Thr Glu
Val Asp Leu Phe 420 425 430 Ile Ser Thr Lys Arg Ile Lys Val Leu Asn
Ala Asp Thr Leu Glu Thr 435 440 445 Met Met Asp His Ala Leu Arg Met
Ile Ser Tyr Ile Ala Asp Ile Gly 450 455 460 Asn Asn Val Val Leu Met
Ala Arg Arg Arg Met Gln Arg Ser Ala Ser 465 470 475 480 Gln Asp Cys
Ile Glu Arg Thr Pro Gly Ala Gln Glu Gly Lys Lys Ser 485 490 495 Tyr
Lys Met Ile Cys His Val Phe Glu Thr Glu Asp Ala Gln Leu Ile 500 505
510 Ala Gln Ser Val Gly Gln Ala Phe Ser Val Ala Tyr Gln Trp Phe Leu
515 520 525 Arg Ala Asn Gly Ile Asn Pro Tyr Asp Leu Ser Gln Lys Glu
Tyr Ser 530 535 540 Asp Ala Ile Asn Thr Gln Glu Met Tyr Asn Asp Glu
Leu Ile His Phe 545 550 555 560 Ser Asn Ser Glu Asn Phe Lys Glu Leu
Gln Leu Glu Lys His Lys His 565 570 575 Glu Ile Leu Gly Val Val Val
Val Glu Ile Gly Trp Gly Ser Ile Leu 580 585 590 Pro Thr Val Lys Leu
Ala Asn Met Met Asn Gly Gly Pro Leu Ala Arg 595 600 605 Ser Gly Lys
Leu Ser Ile Gly Met Gln Ile Met Ser Ile Asn Gly Thr 610 615 620 Ser
Asn Val Gly Leu Pro Leu Ala Thr Cys Gln Gln Ile Ile Lys Gly 625 630
635 640 Leu Lys Asn Gln Thr Arg Val Lys Leu Asn Ile Val Ser Cys Pro
Ser 645 650 655 Val Thr Thr Val Leu Ile Lys Arg Pro Thr Leu Lys Tyr
Gln Leu Gly 660 665 670 Phe Ser Val Val Asn Gly Ile Ile Cys Ser Leu
Met Arg Trp Gly Ile 675 680 685 Ala Glu Arg Gly Gly Val Arg Tyr Gly
His Arg Ile Ile Glu Ile Asn 690 695 700 Gly Ala Ser Val Val Ala Thr
Ala His Glu Lys Asp Val Gln Ala Leu 705 710 715 720 Ser Asn Ser Val
Gly Phe Ile His Met Lys Thr Met Pro Ala Ala Gly 725 730 735 Phe Arg
Leu Leu Thr Gly Gln Glu Thr His Leu Tyr Ile 740 745 97 749 PRT
Artificial Sequence Description of Artificial Sequence Synthetic
Sequence 97 Met Ala His Arg Lys Leu Ala Ser Val Gly Ser Gly Met Leu
Asp His 1 5 10 15 Asp Val Arg Pro Gly Pro Val Pro His Ser Glu Glu
Pro Glu Ser Glu 20 25 30 Asp Met Glu Leu Phe Leu Glu Gly Tyr Val
Pro Glu Gly Leu Gly Leu 35 40 45 Ala Ala Leu Arg Pro Glu Ser Pro
His Pro Glu Glu Gln Glu Cys His 50 55 60 Asn His Ile Pro Asp Gly
Asp Ser Ser Ser Asp Tyr Lys Asn Asn Thr 65 70 75 80 Ser Glu Glu Glu
Asp Tyr Leu Glu Gly Leu Pro Glu Glu Glu Glu Gly 85 90 95 Met Thr
Tyr Tyr Ile Arg Tyr Cys Pro Glu Asn Asp Ser Tyr Leu Glu 100 105 110
Gly Met Asp Cys Gln Gly Glu Glu Tyr Leu Ala His Ser Ala Arg Pro 115
120 125 Val Asp Thr Asp Glu Cys Gln Glu Ser Val Glu Glu Trp Thr Asp
Ser 130 135 140 Ala Gly Thr His Pro His Gly His Glu Ala Glu Gly Val
Gln Asp Tyr 145 150 155 160 Pro Asp Gly Gln Leu Pro Trp Pro Glu Asp
Glu Pro Ser Val Leu Glu 165 170 175 Tyr His Asp Gln Glu Glu Asp Gly
His Tyr Ala Ala Ser Lys Glu Gly 180 185 190 Tyr Gln Asp Tyr Asp Pro
Glu Glu Ala Asn Gly Asn Thr Gly Glu Ser 195 200 205 Pro Tyr Arg Leu
Arg Arg Gly Asp Phe Asp Leu Glu Asp Gln Glu Glu 210 215 220 Asp Ile
Gly Gln Ile Val Ala Glu Ile Lys Met Ser His Ser Met Thr 225 230 235
240 Ser Ile Thr Ser Ala Ser Ile Ala Ser Pro Glu His Gly Pro Glu Pro
245 250 255 Lys Pro Glu Asp Ser Val Glu Ala Cys Pro Leu Ile Lys Ala
Ser Cys 260 265 270 Ser Pro Ser Arg Met Glu Ala Arg Pro Lys Ser Leu
Asn Leu Asn Pro 275 280 285 Glu Ala Lys His Pro Gly Asp Pro Arg Arg
Gly Phe Lys Pro Lys Thr 290 295 300 Arg Thr Ser Glu Glu Arg Leu Lys
Trp Pro His Glu Thr Val Cys Asn 305 310 315 320 Gly Leu Glu Gln Pro
Arg Val Gln Gln Arg Ser Asp Leu Asn Gly Pro 325 330 335 Trp Asp Asn
Asn Asn Ile Pro Glu Thr Lys Tyr Val Ala Ser Phe Pro 340 345 350 Ser
Phe Val Ala Ala Pro Gly Pro Cys Glu Pro Glu Asp Leu Asp Asp 355 360
365 Gly Ile Ile Phe Ala Ala Asn Tyr Glu Gly Ser Thr Gln Leu Leu Ser
370 375 380 Glu Arg Phe Pro Ser Lys Asn Ile Arg Met Met Gln Gly Gln
Glu Ala 385 390 395 400 Val Ser Arg Val Lys Arg His Gln Lys Ala Ala
Lys Ile Lys Lys Lys 405 410 415 Ile Asn Ser Glu Gly Asp Ala Gln Thr
Leu Lys Glu Val Asp Leu Phe 420 425 430 Ile Ser Thr Gln Leu Ile Lys
Val Leu Asn Ala Asp Thr Gln Met Thr 435 440 445 Met Met Asp His Ala
Leu Arg Thr Asn Ser Tyr Ile Ala Asp Ile Gly 450 455 460 Asn Ile Gln
Val Leu Met Ala Arg Arg Arg Met Pro Ser Ser Ala Ser 465 470 475 480
Gln Asp Cys Ile Glu Thr Val Pro Gly Ala Gln Glu Gly Lys Lys Gln 485
490 495 Trp Lys Met Ile Cys His Val Phe Glu Ser Tyr Asp Ala Gln Leu
Ile 500 505 510 Ala Gln Ser Ile Ala Gln Ala Phe Ser Val Ala Tyr Gln
Glu Asp Leu 515 520 525 Arg Ala Asn Gly Ile Asn Pro Glu Glu Leu Ser
Gln Lys Glu Tyr Ser 530 535 540 Asp Ile Phe Asn Thr Gln Glu Met Tyr
Asn Asp Asp Gly Ile His Phe 545 550 555 560 Ser Asn Ser Glu Asn Cys
His Glu Leu Gln Leu Glu Lys His Lys Gly 565 570 575 Ile Ile Leu Gly
Val Val Val Val Glu Ser Lys Trp Gly Ser Ile Leu 580 585 590 Pro Thr
Val Ile Met Ala Asn Met Met Asn Gly Gly Pro Ala Asn Arg 595 600 605
Ser Gly Lys Leu Ser Ile Gly Asp Arg Ile Met Ser Ile Asn Gly Thr 610
615 620 Ser Leu Ser Gly Leu Pro Leu Ala Thr Cys Gln Gly Thr Ile Lys
Gly 625 630 635 640 Leu Lys Asn Gln Thr Gln Trp Lys Leu Asn Ile Val
Ser Cys Pro Pro 645 650 655 Tyr Thr Thr Val Leu Ile Lys Arg Pro Asp
Ala Lys Tyr Gln Leu Gly 660 665 670 Phe Ser Val Gln Asp Gly Ile Ile
Cys Ser Leu Met Arg Gly Glu Ile 675 680 685 Ala Glu Arg Gly Gly Val
Arg Val Phe His Arg Ile Ile Glu Ile Asn 690 695 700 Gly Gln Gly Val
Val Ala Thr Ala His Glu Lys Ile His Gln Ala Leu 705 710 715 720 Ser
Asn Ser Val Gly Glu Lys His Met Lys Thr Met Pro Ala Ala Met 725 730
735 Leu Arg Leu Leu Thr Gly Gln Glu Thr Pro Met Tyr Ile 740 745 98
749 PRT Artificial Sequence Description of Artificial Sequence
Synthetic Sequence 98 Met Ala His Arg Lys Leu Glu Ala Val Gly Ser
Gly Met Leu Asp His 1 5 10 15 Arg Asp Arg Pro Gly Pro Val Pro His
Ser Gln Phe Pro Glu Ser Glu 20 25 30 Asp Met Glu Leu Pro Gly Glu
Gly Tyr Val Pro Glu Gly Leu Glu His 35 40 45 Ala Ala Leu Arg Pro
Glu Ser Pro Ala Ile Glu Glu Gln Glu Cys His 50 55 60 Asn His Ser
Lys Asp Gly Asp Ser Ser Ser Asp Tyr Val Leu Asn Thr 65 70 75 80 Ser
Glu Glu Glu Asp Tyr Asp Met Gly Leu Pro Glu Glu Glu Glu Gly 85 90
95 Ile Asn Tyr Tyr Ile Arg Tyr Cys Pro Glu Asp Gln Ser Tyr Leu Glu
100 105 110 Gly Met Asp Cys Asn Arg Glu Glu Tyr Leu Ala His Ser Ala
His Ser 115 120 125 Val Asp Thr Asp Glu Cys Gln Glu Ala Thr Glu Glu
Trp Thr Asp Ser 130 135 140 Ala Gly Pro Val
Pro His Gly His Glu Ala Glu Gly Ser Trp Asp Tyr 145 150 155 160 Pro
Asp Gly Gln Leu Pro Ile Tyr Glu Asp Glu Pro Ser Val Leu Glu 165 170
175 Ala Ala Asp Gln Glu Glu Asp Gly His Tyr Cys Asp Ser Lys Glu Gly
180 185 190 Tyr Gln Asp Tyr Tyr Glu Glu Glu Ala Asn Gly Asn Thr Gly
Ala Phe 195 200 205 Pro Tyr Arg Leu Arg Arg Gly Asp Gly Gly Leu Glu
Asp Gln Glu Glu 210 215 220 Asp Ile Asp His Ile Val Ala Glu Ile Lys
Met Ser Leu Ile Met Thr 225 230 235 240 Ser Ile Thr Ser Ala Ser Glu
Lys Ser Pro Glu His Gly Pro Glu Pro 245 250 255 Gly Leu Glu Asp Ser
Val Glu Ala Cys Pro Pro Met Lys Ala Ser Cys 260 265 270 Ser Pro Ser
Arg His Asn Ala Arg Pro Lys Ser Leu Asn Leu Leu Gln 275 280 285 Glu
Ala Lys His Pro Gly Asp Pro Gln Ser Gly Phe Lys Pro Lys Thr 290 295
300 Arg Thr Pro Thr Glu Arg Leu Lys Trp Pro His Glu Gln Trp Cys Asn
305 310 315 320 Gly Leu Glu Gln Pro Arg Lys Tyr Gln Arg Ser Asp Leu
Asn Gly Pro 325 330 335 Val Ala Asn Asn Asn Ile Pro Glu Thr Lys Lys
Asp Ala Ser Phe Pro 340 345 350 Ser Phe Val Ala Val Glu Gly Pro Cys
Glu Pro Glu Asp Leu Ile Phe 355 360 365 Gly Ile Ile Phe Ala Ala Asn
Tyr Leu His Ser Thr Gln Leu Leu Ser 370 375 380 Glu Arg Asn Ile Ser
Lys Asn Ile Arg Met Met Gln Ala Lys Glu Ala 385 390 395 400 Val Ser
Arg Val Lys Arg Met Leu Lys Ala Ala Lys Ile Lys Lys Lys 405 410 415
Ala Met Ser Glu Gly Asp Ala Gln Thr Leu Thr Asn Val Asp Leu Phe 420
425 430 Ile Ser Thr Gln Arg Gln Lys Val Leu Asn Ala Asp Thr Gln Glu
Arg 435 440 445 Met Met Asp His Ala Leu Arg Thr Ile Thr Tyr Ile Ala
Asp Ile Gly 450 455 460 Asn Ile Val Trp Leu Met Ala Arg Arg Arg Met
Pro Arg Tyr Ala Ser 465 470 475 480 Gln Asp Cys Ile Glu Thr Thr Ala
Gly Ala Gln Glu Gly Lys Lys Gln 485 490 495 Tyr Asp Met Ile Cys His
Val Phe Glu Ser Glu Glu Ala Gln Leu Ile 500 505 510 Ala Gln Ser Ile
Gly Phe Ala Phe Ser Val Ala Tyr Gln Glu Phe Gly 515 520 525 Arg Ala
Asn Gly Ile Asn Pro Glu Asp His Ser Gln Lys Glu Tyr Ser 530 535 540
Asp Ile Ile Ile Thr Gln Glu Met Tyr Asn Asp Asp Leu Lys His Phe 545
550 555 560 Ser Asn Ser Glu Asn Cys Lys Leu Leu Gln Leu Glu Lys His
Lys Gly 565 570 575 Glu Met Leu Gly Val Val Val Val Glu Ser Gly Asn
Gly Ser Ile Leu 580 585 590 Pro Thr Val Ile Leu Gln Asn Met Met Asn
Gly Gly Pro Ala Ala Ser 595 600 605 Ser Gly Lys Leu Ser Ile Gly Asp
Gln Thr Met Ser Ile Asn Gly Thr 610 615 620 Ser Leu Val Val Leu Pro
Leu Ala Thr Cys Gln Gly Ile Trp Lys Gly 625 630 635 640 Leu Lys Asn
Gln Thr Gln Val Tyr Leu Asn Ile Val Ser Cys Pro Pro 645 650 655 Val
Ala Thr Val Leu Ile Lys Arg Pro Asp Leu Asp Tyr Gln Leu Gly 660 665
670 Phe Ser Val Gln Asn Glu Ile Ile Cys Ser Leu Met Arg Gly Gly Phe
675 680 685 Ala Glu Arg Gly Gly Val Arg Val Gly Gly Arg Ile Ile Glu
Ile Asn 690 695 700 Gly Gln Ser His Val Ala Thr Ala His Glu Lys Ile
Val Ile Ala Leu 705 710 715 720 Ser Asn Ser Val Gly Glu Ile Lys Met
Lys Thr Met Pro Ala Ala Met 725 730 735 Phe Leu Leu Leu Thr Gly Gln
Glu Thr Pro Leu Met Ile 740 745 99 749 PRT Artificial Sequence
Description of Artificial Sequence Synthetic Sequence 99 Met Ala
His Arg Lys Leu Glu Ser Ala Gly Ser Gly Met Leu Asp His 1 5 10 15
Arg Val Asp Pro Gly Pro Val Pro His Ser Gln Glu Glu Glu Ser Glu 20
25 30 Asp Met Glu Leu Pro Leu Phe Gly Tyr Val Pro Glu Gly Leu Glu
Leu 35 40 45 Gly Ala Leu Arg Pro Glu Ser Pro Ala Pro His Glu Gln
Glu Cys His 50 55 60 Asn His Ser Pro Ile Gly Asp Ser Ser Ser Asp
Tyr Val Asn Lys Thr 65 70 75 80 Ser Glu Glu Glu Asp Tyr Asp Glu Leu
Leu Pro Glu Glu Glu Glu Gly 85 90 95 Ile Thr Met Tyr Ile Arg Tyr
Cys Pro Glu Asp Asp Asn Tyr Leu Glu 100 105 110 Gly Met Asp Cys Asn
Gly Gln Glu Tyr Leu Ala His Ser Ala His Pro 115 120 125 Arg Asp Thr
Asp Glu Cys Gln Glu Ala Val Ser Glu Trp Thr Asp Ser 130 135 140 Ala
Gly Pro His Thr His Gly His Glu Ala Glu Gly Ser Gln Val Tyr 145 150
155 160 Pro Asp Gly Gln Leu Pro Ile Pro Trp Asp Glu Pro Ser Val Leu
Glu 165 170 175 Ala His Tyr Gln Glu Glu Asp Gly His Tyr Cys Ala Ala
Lys Glu Gly 180 185 190 Tyr Gln Asp Tyr Tyr Pro Asp Glu Ala Asn Gly
Asn Thr Gly Ala Ser 195 200 205 Glu Tyr Arg Leu Arg Arg Gly Asp Gly
Asp Phe Glu Asp Gln Glu Glu 210 215 220 Asp Ile Asp Gln Gly Val Ala
Glu Ile Lys Met Ser Leu Ser His Thr 225 230 235 240 Ser Ile Thr Ser
Ala Ser Glu Ala Ile Pro Glu His Gly Pro Glu Pro 245 250 255 Gly Pro
Lys Asp Ser Val Glu Ala Cys Pro Pro Ile Leu Ala Ser Cys 260 265 270
Ser Pro Ser Arg His Glu Met Arg Pro Lys Ser Leu Asn Leu Leu Pro 275
280 285 Asn Ala Lys His Pro Gly Asp Pro Gln Arg Gln Phe Lys Pro Lys
Thr 290 295 300 Arg Thr Pro Glu Arg Arg Leu Lys Trp Pro His Glu Gln
Val Ser Asn 305 310 315 320 Gly Leu Glu Gln Pro Arg Lys Gln Thr Arg
Ser Asp Leu Asn Gly Pro 325 330 335 Val Asp Val Asn Asn Ile Pro Glu
Thr Lys Lys Val Trp Ser Phe Pro 340 345 350 Ser Phe Val Ala Val Pro
Tyr Pro Cys Glu Pro Glu Asp Leu Ile Asp 355 360 365 Ala Ile Ile Phe
Ala Ala Asn Tyr Leu Gly Asp Thr Gln Leu Leu Ser 370 375 380 Glu Arg
Asn Pro Glu Lys Asn Ile Arg Met Met Gln Ala Gln Phe Ala 385 390 395
400 Val Ser Arg Val Lys Arg Met Gln Gly Ala Ala Lys Ile Lys Lys Lys
405 410 415 Ala Asn His Glu Gly Asp Ala Gln Thr Leu Thr Glu Ile Asp
Leu Phe 420 425 430 Ile Ser Thr Gln Arg Ile Leu Val Leu Asn Ala Asp
Thr Gln Glu Thr 435 440 445 Asn Met Asp His Ala Leu Arg Thr Ile Ser
Gln Ile Ala Asp Ile Gly 450 455 460 Asn Ile Val Val Arg Met Ala Arg
Arg Arg Met Pro Arg Ser Ser Ser 465 470 475 480 Gln Asp Cys Ile Glu
Thr Thr Pro Thr Ala Gln Glu Gly Lys Lys Gln 485 490 495 Tyr Lys Val
Ile Cys His Val Phe Glu Ser Glu Asp Trp Gln Leu Ile 500 505 510 Ala
Gln Ser Ile Gly Gln Tyr Phe Ser Val Ala Tyr Gln Glu Phe Leu 515 520
525 Ala Ala Asn Gly Ile Asn Pro Glu Asp Leu Asp Gln Lys Glu Tyr Ser
530 535 540 Asp Ile Ile Asn Glu Gln Glu Met Tyr Asn Asp Asp Leu Ile
Phe Phe 545 550 555 560 Ser Asn Ser Glu Asn Cys Lys Glu Gly Gln Leu
Glu Lys His Lys Gly 565 570 575 Glu Ile His Gly Val Val Val Val Glu
Ser Gly Trp Ile Ser Ile Leu 580 585 590 Pro Thr Val Ile Leu Ala Lys
Met Met Asn Gly Gly Pro Ala Ala Arg 595 600 605 Leu Gly Lys Leu Ser
Ile Gly Asp Gln Ile Asn Ser Ile Asn Gly Thr 610 615 620 Ser Leu Val
Gly Gln Pro Leu Ala Thr Cys Gln Gly Ile Ile Arg Gly 625 630 635 640
Leu Lys Asn Gln Thr Gln Val Lys Ser Asn Ile Val Ser Cys Pro Pro 645
650 655 Val Thr Val Val Leu Ile Lys Arg Pro Asp Leu Lys Trp Gln Leu
Gly 660 665 670 Phe Ser Val Gln Asn Gly Tyr Ile Cys Ser Leu Met Arg
Gly Gly Ile 675 680 685 Asp Glu Arg Gly Gly Val Arg Val Gly His Glu
Ile Ile Glu Ile Asn 690 695 700 Gly Gln Ser Val Phe Ala Thr Ala His
Glu Lys Ile Val Gln Gly Leu 705 710 715 720 Ser Asn Ser Val Gly Glu
Ile His His Lys Thr Met Pro Ala Ala Met 725 730 735 Phe Arg Ile Leu
Thr Gly Gln Glu Thr Pro Leu Tyr Lys 740 745 100 749 PRT Artificial
Sequence Description of Artificial Sequence Synthetic Sequence 100
Met Ala His Arg Lys Leu Glu Ser Val Ala Ser Gly Met Leu Asp His 1 5
10 15 Arg Val Arg Asp Gly Pro Val Pro His Ser Gln Glu Pro Phe Ser
Glu 20 25 30 Asp Met Glu Leu Pro Leu Glu His Tyr Val Pro Glu Gly
Leu Glu Leu 35 40 45 Ala Ile Leu Arg Pro Glu Ser Pro Ala Pro Glu
Lys Gln Glu Cys His 50 55 60 Asn His Ser Pro Asp Leu Asp Ser Ser
Ser Asp Tyr Val Asn Asn Met 65 70 75 80 Ser Glu Glu Glu Asp Tyr Asp
Glu Gly Asn Pro Glu Glu Glu Glu Gly 85 90 95 Ile Thr Tyr Gln Ile
Arg Tyr Cys Pro Glu Asp Asp Ser Arg Leu Glu 100 105 110 Gly Met Asp
Cys Asn Gly Glu Ser Tyr Leu Ala His Ser Ala His Pro 115 120 125 Val
Thr Thr Asp Glu Cys Gln Glu Ala Val Glu Val Trp Thr Asp Ser 130 135
140 Ala Gly Pro His Pro Trp Gly His Glu Ala Glu Gly Ser Gln Asp Ala
145 150 155 160 Pro Asp Gly Gln Leu Pro Ile Pro Glu Glu Glu Pro Ser
Val Leu Glu 165 170 175 Ala His Asp Phe Glu Glu Asp Gly His Tyr Cys
Ala Ser Gly Glu Gly 180 185 190 Tyr Gln Asp Tyr Tyr Pro Glu His Ala
Asn Gly Asn Thr Gly Ala Ser 195 200 205 Pro Ile Arg Leu Arg Arg Gly
Asp Gly Asp Leu Lys Asp Gln Glu Glu 210 215 220 Asp Ile Asp Gln Ile
Leu Ala Glu Ile Lys Met Ser Leu Ser Met Met 225 230 235 240 Ser Ile
Thr Ser Ala Ser Glu Ala Ser Asn Glu His Gly Pro Glu Pro 245 250 255
Gly Pro Glu Gln Ser Val Glu Ala Cys Pro Pro Ile Lys Arg Ser Cys 260
265 270 Ser Pro Ser Arg His Glu Ala Ser Pro Lys Ser Leu Asn Leu Leu
Pro 275 280 285 Glu Thr Lys His Pro Gly Asp Pro Gln Arg Gly Val Lys
Pro Lys Thr 290 295 300 Arg Thr Pro Glu Glu Trp Leu Lys Trp Pro His
Glu Gln Val Cys Tyr 305 310 315 320 Gly Leu Glu Gln Pro Arg Lys Gln
Gln Ala Ser Asp Leu Asn Gly Pro 325 330 335 Val Asp Asn Asp Asn Ile
Pro Glu Thr Lys Lys Val Ala Glu Phe Pro 340 345 350 Ser Phe Val Ala
Val Pro Gly Phe Cys Glu Pro Glu Asp Leu Ile Asp 355 360 365 Gly Gly
Ile Phe Ala Ala Asn Tyr Leu Gly Ser His Gln Leu Leu Ser 370 375 380
Glu Arg Asn Pro Ser Ile Asn Ile Arg Met Met Gln Ala Gln Glu Lys 385
390 395 400 Val Ser Arg Val Lys Arg Met Gln Lys Leu Ala Lys Ile Lys
Lys Lys 405 410 415 Ala Asn Ser Met Gly Asp Ala Gln Thr Leu Thr Glu
Val Asn Leu Phe 420 425 430 Ile Ser Thr Gln Arg Ile Lys Gln Leu Asn
Ala Asp Thr Gln Glu Thr 435 440 445 Met Arg Asp His Ala Leu Arg Thr
Ile Ser Tyr Ser Ala Asp Ile Gly 450 455 460 Asn Ile Val Val Leu Thr
Ala Arg Arg Arg Met Pro Arg Ser Ala Val 465 470 475 480 Gln Asp Cys
Ile Glu Thr Thr Pro Gly Trp Gln Glu Gly Lys Lys Gln 485 490 495 Tyr
Lys Met Tyr Cys His Val Phe Glu Ser Glu Asp Ala Ala Leu Ile 500 505
510 Ala Gln Ser Ile Gly Gln Ala Asp Ser Val Ala Tyr Gln Glu Phe Leu
515 520 525 Arg Glu Asn Gly Ile Asn Pro Glu Asp Leu Ser Phe Lys Glu
Tyr Ser 530 535 540 Asp Ile Ile Asn Thr Gly Glu Met Tyr Asn Asp Asp
Leu Ile His His 545 550 555 560 Ser Asn Ser Glu Asn Cys Lys Glu Leu
Ile Leu Glu Lys His Lys Gly 565 570 575 Glu Ile Leu Lys Val Val Val
Val Glu Ser Gly Trp Gly Leu Ile Leu 580 585 590 Pro Thr Val Ile Leu
Ala Asn Asn Met Asn Gly Gly Pro Ala Ala Arg 595 600 605 Ser Gln Lys
Leu Ser Ile Gly Asp Gln Ile Met Arg Ile Asn Gly Thr 610 615 620 Ser
Leu Val Gly Leu Ser Leu Ala Thr Cys Gln Gly Ile Ile Lys Thr 625 630
635 640 Leu Lys Asn Gln Thr Gln Val Lys Leu Val Ile Val Ser Cys Pro
Pro 645 650 655 Val Thr Thr Trp Leu Ile Lys Arg Pro Asp Leu Lys Tyr
Tyr Leu Gly 660 665 670 Phe Ser Val Gln Asn Gly Ile Ala Cys Ser Leu
Met Arg Gly Gly Ile 675 680 685 Ala Asp Arg Gly Gly Val Arg Val Gly
His Arg Glu Ile Glu Ile Asn 690 695 700 Gly Gln Ser Val Val Phe Thr
Ala His Glu Lys Ile Val Gln Ala Gly 705 710 715 720 Ser Asn Ser Val
Gly Glu Ile His Met His Thr Met Pro Ala Ala Met 725 730 735 Phe Arg
Leu Ile Thr Gly Gln Glu Thr Pro Leu Tyr Ile 740 745 101 200 PRT
Artificial Sequence Description of Artificial Sequence Synthetic
Sequence 101 Met Phe Arg Lys Gly Lys Lys Arg His Ser Ser Ser Ser
Ser Gln Ser 1 5 10 15 Ser Glu Ile Ser Thr Lys Ser Lys Ser Val Asp
Ser Ser Leu Gly Gly 20 25 30 Leu Ser Arg Ser Ser Thr Val Ala Ser
Leu Asp Thr Asp Ser Thr Lys 35 40 45 Ser Ser Gly Gln Ser Asn Ser
Asn Leu Asp Thr Cys Ala Glu Phe Arg 50 55 60 Ile Lys Tyr Val Gly
Ala Ile Glu Lys Leu Ala Val Ser Glu Gly Lys 65 70 75 80 Ser Leu Glu
Gly Pro Leu Asp Leu Ile Asn Tyr Ile Asp Val Ala Gln 85 90 95 Gln
Asp Gly Lys Leu Pro Phe Val Pro Leu Glu Glu Glu Phe Ile Leu 100 105
110 Gly Val Ser Lys Tyr Gly Ile Lys Val Ser Thr Thr Asp Gln His Gly
115 120 125 Val Leu His Arg His Ala Leu Tyr Leu Ile Ile Arg Met Val
Cys Tyr 130 135 140 Asp Asp Gly Leu Gly Ala Gly Lys Ser Leu Leu Ala
Leu Lys Thr Thr 145 150 155 160 Asp Ala Ser Asn Glu Glu Tyr Ser Leu
Trp Val Tyr Gln Cys Asn Ser 165 170 175 Leu Glu Gln Ala Gln Ala Ile
Cys Lys Val Leu Ser Thr Ala Phe Asp 180 185 190 Ser Val Leu Thr Ser
Asp Lys Ser 195 200 102 200 PRT Artificial Sequence Description of
Artificial Sequence Synthetic Sequence 102 Met Ala Arg Lys Gly Lys
Lys Arg His Ser Ser Asp Ser Ser Gln Ser 1 5 10 15 Ser Glu Ile Ser
Thr Glu Ser Lys Ser Val Asp Ser Ser Leu Gly Phe 20 25 30 Leu Ser
Arg Ser Ser Thr Val Ala Ser Gly Asp Thr Asp Ser Thr Lys 35 40 45
Ser Ser Gly His Ser Asn Ser Asn Leu Asp Thr Cys Ala Ile Phe Arg 50
55 60 Ile Lys Tyr Val Gly Ala Ile Lys Lys Leu Ala Val Ser Glu Gly
Lys 65 70 75 80 Ser Met Glu Gly Pro Leu Asp Leu Ile Asn Tyr Asn Asp
Val Ala Gln 85 90
95 Gln Asp Gly Lys Leu Gln Phe Val Pro Leu Glu Glu Glu Phe Ile Arg
100 105 110 Gly Val Ser Lys Tyr Gly Ile Lys Val Thr Thr Thr Asp Gln
His Gly 115 120 125 Val Leu His Val His Ala Leu Tyr Leu Ile Ile Arg
Met Trp Cys Tyr 130 135 140 Asp Asp Gly Leu Gly Ala Gly Tyr Ser Leu
Leu Ala Leu Lys Thr Thr 145 150 155 160 Asp Asp Ser Asn Glu Glu Tyr
Ser Leu Trp Val Glu Gln Cys Asn Ser 165 170 175 Leu Glu Gln Ala Gln
Phe Ile Cys Lys Val Leu Ser Thr Ala Phe Gly 180 185 190 Ser Val Leu
Thr Ser Asp Lys Ser 195 200 103 200 PRT Artificial Sequence
Description of Artificial Sequence Synthetic Sequence 103 Met Phe
Ala Lys Gly Lys Lys Arg His Ser Ser Ser Asp Ser Gln Ser 1 5 10 15
Ser Glu Ile Ser Thr Lys Glu Lys Ser Val Asp Ser Ser Leu Gly Gly 20
25 30 Phe Ser Arg Ser Ser Thr Val Ala Ser Leu Gly Thr Asp Ser Thr
Lys 35 40 45 Ser Ser Gly Gln His Asn Ser Asn Leu Asp Thr Cys Ala
Glu Ile Arg 50 55 60 Ile Lys Tyr Val Gly Ala Ile Glu Leu Leu Ala
Val Ser Glu Gly Lys 65 70 75 80 Ser Leu Met Gly Pro Leu Asp Leu Ile
Asn Tyr Ile Asn Val Ala Gln 85 90 95 Gln Asp Gly Lys Leu Pro Gln
Val Pro Leu Glu Glu Glu Phe Ile Leu 100 105 110 Arg Val Ser Lys Tyr
Gly Ile Lys Val Ser Ser Thr Asp Gln His Gly 115 120 125 Val Leu His
Arg Thr Ala Leu Tyr Leu Ile Ile Arg Met Val Val Tyr 130 135 140 Asp
Asp Gly Leu Gly Ala Gly Lys Trp Leu Leu Ala Leu Lys Thr Thr 145 150
155 160 Asp Ala Tyr Asn Glu Glu Tyr Ser Leu Trp Val Tyr Ala Cys Asn
Ser 165 170 175 Leu Glu Gln Ala Gln Ala Asp Cys Lys Val Leu Ser Thr
Ala Phe Asp 180 185 190 Glu Val Leu Thr Ser Asp Lys Ser 195 200 104
200 PRT Artificial Sequence Description of Artificial Sequence
Synthetic Sequence 104 Met Phe Arg Ala Gly Lys Lys Arg His Ser Ser
Ser Ser Asp Gln Ser 1 5 10 15 Ser Glu Ile Ser Thr Lys Ser Glu Ser
Val Asp Ser Ser Leu Gly Gly 20 25 30 Leu Phe Arg Ser Ser Thr Val
Ala Ser Leu Asp Gly Asp Ser Thr Lys 35 40 45 Ser Ser Gly Gln Ser
His Ser Asn Leu Asp Thr Cys Ala Glu Phe Ile 50 55 60 Ile Lys Tyr
Val Gly Ala Ile Glu Lys Lys Ala Val Ser Glu Gly Lys 65 70 75 80 Ser
Leu Glu Leu Pro Leu Asp Leu Ile Asn Tyr Ile Asp Met Ala Gln 85 90
95 Gln Asp Gly Lys Leu Pro Phe Asn Pro Leu Glu Glu Glu Phe Ile Leu
100 105 110 Gly Gln Ser Lys Tyr Gly Ile Lys Val Ser Thr Arg Asp Gln
His Gly 115 120 125 Val Leu His Arg His Ser Leu Tyr Leu Ile Ile Arg
Met Val Cys Thr 130 135 140 Asp Asp Gly Leu Gly Ala Gly Lys Ser Val
Leu Ala Leu Lys Thr Thr 145 150 155 160 Asp Ala Ser Trp Glu Glu Tyr
Ser Leu Trp Val Tyr Gln Tyr Asn Ser 165 170 175 Leu Glu Gln Ala Gln
Ala Ile Ala Lys Val Leu Ser Thr Ala Phe Asp 180 185 190 Ser Asp Leu
Thr Ser Asp Lys Ser 195 200 105 200 PRT Artificial Sequence
Description of Artificial Sequence Synthetic Sequence 105 Met Phe
Arg Lys Ala Lys Lys Arg His Ser Ser Ser Ser Ser Asp Ser 1 5 10 15
Ser Glu Ile Ser Thr Lys Ser Lys Glu Val Asp Ser Ser Leu Gly Gly 20
25 30 Leu Ser Phe Ser Ser Thr Val Ala Ser Leu Asp Thr Gly Ser Thr
Lys 35 40 45 Ser Ser Gly Gln Ser Asn His Asn Leu Asp Thr Cys Ala
Glu Phe Arg 50 55 60 Lys Lys Tyr Val Gly Ala Ile Glu Lys Leu Leu
Val Ser Glu Gly Lys 65 70 75 80 Ser Leu Glu Gly Met Leu Asp Leu Ile
Asn Tyr Ile Asp Val Asn Gln 85 90 95 Gln Asp Gly Lys Leu Pro Phe
Val Gln Leu Glu Glu Glu Phe Ile Leu 100 105 110 Gly Val Arg Lys Tyr
Gly Ile Lys Val Ser Thr Thr Ser Gln His Gly 115 120 125 Val Leu His
Arg His Ala Thr Tyr Leu Ile Ile Arg Met Val Cys Tyr 130 135 140 Val
Asp Gly Leu Gly Ala Gly Lys Ser Leu Trp Ala Leu Lys Thr Thr 145 150
155 160 Asp Ala Ser Asn Tyr Glu Tyr Ser Leu Trp Val Tyr Gln Cys Ala
Ser 165 170 175 Leu Glu Gln Ala Gln Ala Ile Cys Asp Val Leu Ser Thr
Ala Phe Asp 180 185 190 Ser Val Glu Thr Ser Asp Lys Ser 195 200 106
200 PRT Artificial Sequence Description of Artificial Sequence
Synthetic Sequence 106 Met Phe Arg Lys Gly Ala Lys Arg His Ser Ser
Ser Ser Ser Gln Asp 1 5 10 15 Ser Glu Ile Ser Thr Lys Ser Lys Ser
Glu Asp Ser Ser Leu Gly Gly 20 25 30 Leu Ser Arg Phe Ser Thr Val
Ala Ser Leu Asp Thr Asp Gly Thr Lys 35 40 45 Ser Ser Gly Gln Ser
Asn Ser His Leu Asp Thr Cys Ala Glu Phe Arg 50 55 60 Ile Ile Tyr
Val Gly Ala Ile Glu Lys Leu Ala Lys Ser Glu Gly Lys 65 70 75 80 Ser
Leu Glu Gly Pro Met Asp Leu Ile Asn Tyr Ile Asp Val Ala Asn 85 90
95 Gln Asp Gly Lys Leu Pro Phe Val Pro Gln Glu Glu Glu Phe Ile Leu
100 105 110 Gly Val Ser Arg Tyr Gly Ile Lys Val Ser Thr Thr Asp Ser
His Gly 115 120 125 Val Leu His Arg His Ala Leu Thr Leu Ile Ile Arg
Met Val Cys Tyr 130 135 140 Asp Val Gly Leu Gly Ala Gly Lys Ser Leu
Leu Trp Leu Lys Thr Thr 145 150 155 160 Asp Ala Ser Asn Glu Tyr Tyr
Ser Leu Trp Val Tyr Gln Cys Asn Ala 165 170 175 Leu Glu Gln Ala Gln
Ala Ile Cys Lys Asp Leu Ser Thr Ala Phe Asp 180 185 190 Ser Val Leu
Glu Ser Asp Lys Ser 195 200 107 200 PRT Artificial Sequence
Description of Artificial Sequence Synthetic Sequence 107 Met Phe
Arg Lys Gly Lys Ala Arg His Ser Ser Ser Ser Ser Gln Ser 1 5 10 15
Asp Glu Ile Ser Thr Lys Ser Lys Ser Val Glu Ser Ser Leu Gly Gly 20
25 30 Leu Ser Arg Ser Phe Thr Val Ala Ser Leu Asp Thr Asp Ser Gly
Lys 35 40 45 Ser Ser Gly Gln Ser Asn Ser Asn His Asp Thr Cys Ala
Glu Phe Arg 50 55 60 Ile Lys Ile Val Gly Ala Ile Glu Lys Leu Ala
Val Lys Glu Gly Lys 65 70 75 80 Ser Leu Glu Gly Pro Leu Leu Leu Ile
Asn Tyr Ile Asp Val Ala Gln 85 90 95 Met Asp Gly Lys Leu Pro Phe
Val Pro Leu Asn Glu Glu Phe Ile Leu 100 105 110 Gly Val Ser Lys Gln
Gly Ile Lys Val Ser Thr Thr Asp Gln Arg Gly 115 120 125 Val Leu His
Arg His Ala Leu Tyr Ser Ile Ile Arg Met Val Cys Tyr 130 135 140 Asp
Asp Thr Leu Gly Ala Gly Lys Ser Leu Leu Ala Val Lys Thr Thr 145 150
155 160 Asp Ala Ser Asn Glu Glu Trp Ser Leu Trp Val Tyr Gln Cys Asn
Ser 165 170 175 Tyr Glu Gln Ala Gln Ala Ile Cys Lys Val Ala Ser Thr
Ala Phe Asp 180 185 190 Ser Val Leu Thr Asp Asp Lys Ser 195 200 108
200 PRT Artificial Sequence Description of Artificial Sequence
Synthetic Sequence 108 Met Phe Arg Lys Gly Lys Lys Ala His Ser Ser
Ser Ser Ser Gln Ser 1 5 10 15 Ser Asp Ile Ser Thr Lys Ser Lys Ser
Val Asp Glu Ser Leu Gly Gly 20 25 30 Leu Ser Arg Ser Ser Phe Val
Ala Ser Leu Asp Thr Asp Ser Thr Gly 35 40 45 Ser Ser Gly Gln Ser
Asn Ser Asn Leu His Thr Cys Ala Glu Phe Arg 50 55 60 Ile Lys Tyr
Ile Gly Ala Ile Glu Lys Leu Ala Val Ser Lys Gly Lys 65 70 75 80 Ser
Leu Glu Gly Pro Leu Asp Met Ile Asn Tyr Ile Asp Val Ala Gln 85 90
95 Gln Asn Gly Lys Leu Pro Phe Val Pro Leu Glu Gln Glu Phe Ile Leu
100 105 110 Gly Val Ser Lys Tyr Arg Ile Lys Val Ser Thr Thr Asp Gln
His Ser 115 120 125 Val Leu His Arg His Ala Leu Tyr Leu Thr Ile Arg
Met Val Cys Tyr 130 135 140 Asp Asp Gly Val Gly Ala Gly Lys Ser Leu
Leu Ala Leu Trp Thr Thr 145 150 155 160 Asp Ala Ser Asn Glu Glu Tyr
Tyr Leu Trp Val Tyr Gln Cys Asn Ser 165 170 175 Leu Ala Gln Ala Gln
Ala Ile Cys Lys Val Leu Asp Thr Ala Phe Asp 180 185 190 Ser Val Leu
Thr Ser Glu Lys Ser 195 200 109 200 PRT Artificial Sequence
Description of Artificial Sequence Synthetic Sequence 109 Met Phe
Arg Lys Gly Lys Lys Arg Ala Ser Ser Ser Ser Ser Gln Ser 1 5 10 15
Ser Glu Asp Ser Thr Lys Ser Lys Ser Val Asp Ser Glu Leu Gly Gly 20
25 30 Leu Ser Arg Ser Ser Thr Phe Ala Ser Leu Asp Thr Asp Ser Thr
Lys 35 40 45 Gly Ser Gly Gln Ser Asn Ser Asn Leu Asp His Cys Ala
Glu Phe Arg 50 55 60 Ile Lys Tyr Val Ile Ala Ile Glu Lys Leu Ala
Val Ser Glu Lys Lys 65 70 75 80 Ser Leu Glu Gly Pro Leu Asp Leu Leu
Asn Tyr Ile Asp Val Ala Gln 85 90 95 Gln Asp Met Lys Leu Pro Phe
Val Pro Leu Glu Glu Asn Phe Ile Leu 100 105 110 Gly Val Ser Lys Tyr
Gly Gln Lys Val Ser Thr Thr Asp Gln His Gly 115 120 125 Arg Leu His
Arg His Ala Leu Tyr Leu Ile Ser Arg Met Val Cys Tyr 130 135 140 Asp
Asp Gly Leu Thr Ala Gly Lys Ser Leu Leu Ala Leu Lys Val Thr 145 150
155 160 Asp Ala Ser Asn Glu Glu Tyr Ser Trp Trp Val Tyr Gln Cys Asn
Ser 165 170 175 Leu Glu Tyr Ala Gln Ala Ile Cys Lys Val Leu Ser Ala
Ala Phe Asp 180 185 190 Ser Val Leu Thr Ser Asp Asp Ser 195 200 110
200 PRT Artificial Sequence Description of Artificial Sequence
Synthetic Sequence 110 Met Phe Arg Lys Gly Lys Lys Arg His Ala Ser
Ser Ser Ser Gln Ser 1 5 10 15 Ser Glu Ile Asp Thr Lys Ser Lys Ser
Val Asp Ser Ser Glu Gly Gly 20 25 30 Leu Ser Arg Ser Ser Thr Val
Phe Ser Leu Asp Thr Asp Ser Thr Lys 35 40 45 Ser Gly Gly Gln Ser
Asn Ser Asn Leu Asp Thr His Ala Glu Phe Arg 50 55 60 Ile Lys Tyr
Val Gly Ile Ile Glu Lys Leu Ala Val Ser Glu Gly Leu 65 70 75 80 Ser
Leu Glu Gly Pro Leu Asp Leu Ile Met Tyr Ile Asp Val Ala Gln 85 90
95 Gln Asp Gly Asn Leu Pro Phe Val Pro Leu Glu Glu Glu Gln Ile Leu
100 105 110 Gly Val Ser Lys Tyr Gly Ile Arg Val Ser Thr Thr Asp Gln
His Gly 115 120 125 Val Ser His Arg His Ala Leu Tyr Leu Ile Ile Thr
Met Val Cys Tyr 130 135 140 Asp Asp Gly Leu Gly Val Gly Lys Ser Leu
Leu Ala Leu Lys Thr Trp 145 150 155 160 Asp Ala Ser Asn Glu Glu Tyr
Ser Leu Tyr Val Tyr Gln Cys Asn Ser 165 170 175 Leu Glu Gln Asp Gln
Ala Ile Cys Lys Val Leu Ser Thr Glu Phe Asp 180 185 190 Ser Val Leu
Thr Ser Asp Lys Phe 195 200 111 185 PRT Artificial Sequence
Description of Artificial Sequence Synthetic Sequence 111 Met Thr
Thr Pro Asn Lys Thr Pro Pro Gly Ala Asp Pro Lys Gln Leu 1 5 10 15
Glu Arg Thr Gly Thr Val Arg Glu Ile Gly Ser Gln Ala Val Trp Ser 20
25 30 Leu Ser Ser Cys Lys Pro Gly Phe Gly Val Asp Gln Leu Arg Asp
Asp 35 40 45 Asn Leu Glu Thr Tyr Trp Gln Ser Asp Gly Ser Gln Pro
His Leu Val 50 55 60 Asn Ile Gln Phe Arg Arg Lys Thr Thr Val Lys
Thr Leu Cys Ile Tyr 65 70 75 80 Ala Asp Tyr Lys Ser Asp Glu Ser Tyr
Thr Pro Ser Lys Ile Ser Val 85 90 95 Arg Val Gly Asn Asn Phe His
Asn Leu Gln Glu Ile Arg Gln Leu Glu 100 105 110 Leu Val Glu Pro Ser
Gly Trp Ile His Val Pro Leu Thr Asp Asn His 115 120 125 Lys Lys Pro
Thr Arg Thr Phe Met Ile Gln Ile Ala Val Leu Ala Asn 130 135 140 His
Gln Asn Gly Arg Asp Thr His Met Arg Gln Ile Lys Ile Tyr Thr 145 150
155 160 Pro Val Glu Glu Ser Ser Ile Gly Lys Phe Pro Arg Cys Thr Thr
Ile 165 170 175 Asp Phe Met Met Tyr Arg Ser Ile Arg 180 185 112 185
PRT Artificial Sequence Description of Artificial Sequence
Synthetic Sequence 112 Met Ala Thr Pro Asn Lys Thr Pro Pro Gly Ala
Glu Pro Lys Gln Leu 1 5 10 15 Glu Arg Thr Gly Thr Phe Arg Glu Ile
Gly Ser Gln Ala Val Trp Gly 20 25 30 Leu Ser Ser Cys Lys Pro Gly
Phe Gly His Asp Gln Leu Arg Asp Asp 35 40 45 Asn Leu Glu Ile Tyr
Trp Gln Ser Asp Gly Ser Gln Pro Lys Leu Val 50 55 60 Asn Ile Gln
Phe Arg Arg Lys Leu Thr Val Lys Thr Leu Cys Ile Tyr 65 70 75 80 Ala
Met Tyr Lys Ser Asp Glu Ser Tyr Thr Pro Asn Lys Ile Ser Val 85 90
95 Arg Val Gly Asn Asn Gln His Asn Leu Gln Glu Ile Arg Gln Leu Arg
100 105 110 Leu Val Glu Pro Ser Gly Trp Ile His Ser Pro Leu Thr Asp
Asn His 115 120 125 Lys Lys Pro Val Arg Thr Phe Met Ile Gln Ile Ala
Val Trp Ala Asn 130 135 140 His Gln Asn Gly Arg Asp Thr Tyr Met Arg
Gln Ile Lys Ile Tyr Thr 145 150 155 160 Pro Ala Glu Glu Ser Ser Ile
Gly Lys Phe Pro Asp Cys Thr Thr Ile 165 170 175 Asp Phe Met Met Tyr
Glu Ser Ile Arg 180 185 113 185 PRT Artificial Sequence Description
of Artificial Sequence Synthetic Sequence 113 Met Thr Ala Pro Asn
Lys Thr Pro Pro Gly Ala Asp Asp Lys Gln Leu 1 5 10 15 Glu Arg Thr
Gly Thr Val Glu Glu Ile Gly Ser Gln Ala Val Trp Ser 20 25 30 Phe
Ser Ser Cys Lys Pro Gly Phe Gly Val Gly Gln Leu Arg Asp Asp 35 40
45 Asn Leu Glu Thr His Trp Gln Ser Asp Gly Ser Gln Pro His Ile Val
50 55 60 Asn Ile Gln Phe Arg Arg Lys Thr Lys Val Lys Thr Leu Cys
Ile Tyr 65 70 75 80 Ala Asp Leu Lys Ser Asp Glu Ser Tyr Thr Pro Ser
Met Ile Ser Val 85 90 95 Arg Val Gly Asn Asn Phe Asn Asn Leu Gln
Glu Ile Arg Gln Leu Glu 100 105 110 Gln Val Glu Pro Ser Gly Trp Ile
His Val Arg Leu Thr Asp Asn His 115 120 125 Lys Lys Pro Thr Ser Thr
Phe Met Ile Gln Ile Ala Val Leu Thr Asn 130 135 140 His Gln Asn Gly
Arg Asp Thr His Val Arg Gln Ile Lys Ile Tyr Thr 145 150 155 160 Pro
Val Trp Glu Ser Ser Ile Gly Lys Phe Pro Arg Tyr Thr Thr Ile 165 170
175 Asp Phe Met Met Tyr Arg Ala Ile Arg 180 185 114 185 PRT
Artificial Sequence Description of Artificial Sequence Synthetic
Sequence 114 Met Thr Thr Ala Asn Lys Thr Pro Pro Gly Ala Asp Pro
Asp Gln Leu 1 5 10
15 Glu Arg Thr Gly Thr Val Arg Phe Ile Gly Ser Gln Ala Val Trp Ser
20 25 30 Leu Gly Ser Cys Lys Pro Gly Phe Gly Val Asp His Leu Arg
Asp Asp 35 40 45 Asn Leu Glu Thr Tyr Ile Gln Ser Asp Gly Ser Gln
Pro His Leu Lys 50 55 60 Asn Ile Gln Phe Arg Arg Lys Thr Thr Leu
Lys Thr Leu Cys Ile Tyr 65 70 75 80 Ala Asp Tyr Met Ser Asp Glu Ser
Tyr Thr Pro Ser Lys Asn Ser Val 85 90 95 Arg Val Gly Asn Asn Phe
His Gln Leu Gln Glu Ile Arg Gln Leu Glu 100 105 110 Leu Arg Glu Pro
Ser Gly Trp Ile His Val Pro Ser Thr Asp Asn His 115 120 125 Lys Lys
Pro Thr Arg Thr Phe Met Ile Gln Ile Ala Val Leu Ala Val 130 135 140
His Gln Asn Gly Arg Asp Thr His Met Trp Gln Ile Lys Ile Tyr Thr 145
150 155 160 Pro Val Glu Tyr Ser Ser Ile Gly Lys Phe Pro Arg Cys Ala
Thr Ile 165 170 175 Asp Phe Met Met Tyr Arg Ser Asp Arg 180 185 115
185 PRT Artificial Sequence Description of Artificial Sequence
Synthetic Sequence 115 Met Thr Thr Pro Ala Lys Thr Pro Pro Gly Ala
Asp Pro Lys Asp Leu 1 5 10 15 Glu Arg Thr Gly Thr Val Arg Glu Glu
Gly Ser Gln Ala Val Trp Ser 20 25 30 Leu Ser Phe Cys Lys Pro Gly
Phe Gly Val Asp Gln Gly Arg Asp Asp 35 40 45 Asn Leu Glu Thr Tyr
Trp His Ser Asp Gly Ser Gln Pro His Leu Val 50 55 60 Ile Ile Gln
Phe Arg Arg Lys Thr Thr Val Leu Thr Leu Cys Ile Tyr 65 70 75 80 Ala
Asp Tyr Lys Met Asp Glu Ser Tyr Thr Pro Ser Lys Ile Asn Val 85 90
95 Arg Val Gly Asn Asn Phe His Asn Gln Gln Glu Ile Arg Gln Leu Glu
100 105 110 Leu Val Arg Pro Ser Gly Trp Ile His Val Pro Leu Ser Asp
Asn His 115 120 125 Lys Lys Pro Thr Arg Thr Thr Met Ile Gln Ile Ala
Val Leu Ala Asn 130 135 140 Val Gln Asn Gly Arg Asp Thr His Met Arg
Trp Ile Lys Ile Tyr Thr 145 150 155 160 Pro Val Glu Glu Tyr Ser Ile
Gly Lys Phe Pro Arg Cys Thr Ala Ile 165 170 175 Asp Phe Met Met Tyr
Arg Ser Ile Asp 180 185 116 185 PRT Artificial Sequence Description
of Artificial Sequence Synthetic Sequence 116 Met Thr Thr Pro Asn
Ala Thr Pro Pro Gly Ala Asp Pro Lys Gln Asp 1 5 10 15 Glu Arg Thr
Gly Thr Val Arg Glu Ile Glu Ser Gln Ala Val Trp Ser 20 25 30 Leu
Ser Ser Phe Lys Pro Gly Phe Gly Val Asp Gln Leu Gly Asp Asp 35 40
45 Asn Leu Glu Thr Tyr Trp Gln His Asp Gly Ser Gln Pro His Leu Val
50 55 60 Asn Lys Gln Phe Arg Arg Lys Thr Thr Val Lys Leu Leu Cys
Ile Tyr 65 70 75 80 Ala Asp Tyr Lys Ser Met Glu Ser Tyr Thr Pro Ser
Lys Ile Ser Asn 85 90 95 Arg Val Gly Asn Asn Phe His Asn Leu Arg
Glu Ile Arg Gln Leu Glu 100 105 110 Leu Val Glu Ser Ser Gly Trp Ile
His Val Pro Leu Thr Thr Asn His 115 120 125 Lys Lys Pro Thr Arg Thr
Phe Val Ile Gln Ile Ala Val Leu Ala Asn 130 135 140 His Trp Asn Gly
Arg Asp Thr His Met Arg Gln Tyr Lys Ile Tyr Thr 145 150 155 160 Pro
Val Glu Glu Ser Ala Ile Gly Lys Phe Pro Arg Cys Thr Thr Asp 165 170
175 Asp Phe Met Met Tyr Arg Ser Ile Arg 180 185 117 185 PRT
Artificial Sequence Description of Artificial Sequence Synthetic
Sequence 117 Met Thr Thr Pro Asn Lys Ala Pro Pro Gly Ala Asp Pro
Lys Gln Leu 1 5 10 15 Asp Arg Thr Gly Thr Val Arg Glu Ile Gly Glu
Gln Ala Val Trp Ser 20 25 30 Leu Ser Ser Cys Phe Pro Gly Phe Gly
Val Asp Gln Leu Arg Gly Asp 35 40 45 Asn Leu Glu Thr Tyr Trp Gln
Ser His Gly Ser Gln Pro His Leu Val 50 55 60 Asn Ile Ile Phe Arg
Arg Lys Thr Thr Val Lys Thr Lys Cys Ile Tyr 65 70 75 80 Ala Asp Tyr
Lys Ser Asp Leu Ser Tyr Thr Pro Ser Lys Ile Ser Val 85 90 95 Met
Val Gly Asn Asn Phe His Asn Leu Gln Asn Ile Arg Gln Leu Glu 100 105
110 Leu Val Glu Pro Gln Gly Trp Ile His Val Pro Leu Thr Asp Arg His
115 120 125 Lys Lys Pro Thr Arg Thr Phe Met Ser Gln Ile Ala Val Leu
Ala Asn 130 135 140 His Gln Thr Gly Arg Asp Thr His Met Arg Gln Ile
Val Ile Tyr Thr 145 150 155 160 Pro Val Glu Glu Ser Ser Trp Gly Lys
Phe Pro Arg Cys Thr Thr Ile 165 170 175 Tyr Phe Met Met Tyr Arg Ser
Ile Arg 180 185 118 185 PRT Artificial Sequence Description of
Artificial Sequence Synthetic Sequence 118 Met Thr Thr Pro Asn Lys
Thr Ala Pro Gly Ala Asp Pro Lys Gln Leu 1 5 10 15 Glu Asp Thr Gly
Thr Val Arg Glu Ile Gly Ser Glu Ala Val Trp Ser 20 25 30 Leu Ser
Ser Cys Lys Phe Gly Phe Gly Val Asp Gln Leu Arg Asp Gly 35 40 45
Asn Leu Glu Thr Tyr Trp Gln Ser Asp His Ser Gln Pro His Leu Val 50
55 60 Asn Ile Gln Ile Arg Arg Lys Thr Thr Val Lys Thr Leu Lys Ile
Tyr 65 70 75 80 Ala Asp Tyr Lys Ser Asp Glu Leu Tyr Thr Pro Ser Lys
Ile Ser Val 85 90 95 Arg Met Gly Asn Asn Phe His Asn Leu Gln Glu
Asn Arg Gln Leu Glu 100 105 110 Leu Val Glu Pro Ser Gln Trp Ile His
Val Pro Leu Thr Asp Asn Arg 115 120 125 Lys Lys Pro Thr Arg Thr Phe
Met Ile Ser Ile Ala Val Leu Ala Asn 130 135 140 His Gln Asn Thr Arg
Asp Thr His Met Arg Gln Ile Lys Val Tyr Thr 145 150 155 160 Pro Val
Glu Glu Ser Ser Ile Trp Lys Phe Pro Arg Cys Thr Thr Ile 165 170 175
Asp Tyr Met Met Tyr Arg Ser Ile Arg 180 185 119 185 PRT Artificial
Sequence Description of Artificial Sequence Synthetic Sequence 119
Met Thr Thr Pro Asn Lys Thr Pro Ala Gly Ala Asp Pro Lys Gln Leu 1 5
10 15 Glu Arg Asp Gly Thr Val Arg Glu Ile Gly Ser Gln Glu Val Trp
Ser 20 25 30 Leu Ser Ser Cys Lys Pro Phe Phe Gly Val Asp Gln Leu
Arg Asp Asp 35 40 45 Gly Leu Glu Thr Tyr Trp Gln Ser Asp Gly His
Gln Pro His Leu Val 50 55 60 Asn Ile Gln Phe Ile Arg Lys Thr Thr
Val Lys Thr Leu Cys Lys Tyr 65 70 75 80 Ala Asp Tyr Lys Ser Asp Glu
Ser Leu Thr Pro Ser Lys Ile Ser Val 85 90 95 Arg Val Met Asn Asn
Phe His Asn Leu Gln Glu Ile Asn Gln Leu Glu 100 105 110 Leu Val Glu
Pro Ser Gly Gln Ile His Val Pro Leu Thr Asp Asn His 115 120 125 Arg
Lys Pro Thr Arg Thr Phe Met Ile Gln Ser Ala Val Leu Ala Asn 130 135
140 His Gln Asn Gly Thr Asp Thr His Met Arg Gln Ile Lys Ile Val Thr
145 150 155 160 Pro Val Glu Glu Ser Ser Ile Gly Trp Phe Pro Arg Cys
Thr Thr Ile 165 170 175 Asp Phe Tyr Met Tyr Arg Ser Ile Arg 180 185
120 185 PRT Artificial Sequence Description of Artificial Sequence
Synthetic Sequence 120 Met Thr Thr Pro Asn Lys Thr Pro Pro Ala Ala
Asp Pro Lys Gln Leu 1 5 10 15 Glu Arg Thr Asp Thr Val Arg Glu Ile
Gly Ser Gln Ala Glu Trp Ser 20 25 30 Leu Ser Ser Cys Lys Pro Gly
Gly Gly Val Asp Gln Leu Arg Asp Asp 35 40 45 Asn His Glu Thr Tyr
Trp Gln Ser Asp Gly Ser Ile Pro His Leu Val 50 55 60 Asn Ile Gln
Phe Arg Lys Lys Thr Thr Val Lys Thr Leu Cys Ile Leu 65 70 75 80 Ala
Asp Tyr Lys Ser Asp Glu Ser Tyr Met Pro Ser Lys Ile Ser Val 85 90
95 Arg Val Gly Gln Asn Phe His Asn Leu Gln Glu Ile Arg Arg Leu Glu
100 105 110 Leu Val Glu Pro Ser Gly Trp Ser His Val Pro Leu Thr Asp
Asn His 115 120 125 Lys Thr Pro Thr Arg Thr Phe Met Ile Gln Ile Val
Val Leu Ala Asn 130 135 140 His Gln Asn Gly Arg Trp Thr His Met Arg
Gln Ile Lys Ile Tyr Tyr 145 150 155 160 Pro Val Glu Glu Ser Ser Ile
Gly Lys Ala Pro Arg Cys Thr Thr Ile 165 170 175 Asp Phe Met Asp Tyr
Arg Ser Ile Arg 180 185 121 50 PRT human 121 Lys Asn Trp Arg Leu
Lys Asn Ile Asn Ser Ile Asn Phe Asp Asn Pro 1 5 10 15 Val Tyr Gln
Lys Thr Thr Glu Asp Glu Val His Ile Cys His Asn Gln 20 25 30 Asp
Gly Tyr Ser Tyr Pro Ser Arg Gln Met Val Ser Leu Glu Asp Asp 35 40
45 Val Ala 50 122 54 PRT mouse 122 Arg Asn Trp Gln His Lys Asn Met
Lys Ser Met Asn Phe Asp Asn Pro 1 5 10 15 Val Tyr Leu Lys Thr Thr
Glu Glu Asp Leu Ser Ile Asp Ile Gly Arg 20 25 30 His Ser Ala Ser
Val Gly His Thr Tyr Pro Ala Ile Ser Val Val Ser 35 40 45 Thr Asp
Asp Asp Leu Ala 50 123 62 PRT human 123 Thr Lys His Arg Arg Leu Gln
Ser Ser Phe Thr Ala Phe Ala Asn Ser 1 5 10 15 His Tyr Ser Ser Arg
Leu Gly Ser Ala Ile Phe Ser Ser Gly Asp Asp 20 25 30 Leu Gly Glu
Asp Asp Glu Asp Ala Pro Met Ile Thr Gly Phe Ser Asp 35 40 45 Asp
Val Pro Met Ala Ala Ala Arg Val Asp Leu Gln Pro Ser 50 55 60 124 57
PRT mouse 124 Trp Arg Asn Trp Lys Arg Lys Asn Thr Lys Ser Met Asn
Phe Asp Asn 1 5 10 15 Pro Val Tyr Arg Lys Thr Thr Glu Glu Glu Glu
Glu Asp Glu Leu His 20 25 30 Ile Gly Arg Thr Ala Gln Ile Gly His
Val Tyr Pro Ala Arg Val Ala 35 40 45 Leu Ser Leu Glu Asp Asp Gly
Leu Pro 50 55 125 116 PRT mouse 125 Trp Arg Asn Trp Lys Arg Lys Asn
Thr Lys Ser Met Asn Phe Asp Asn 1 5 10 15 Pro Val Tyr Arg Lys Thr
Thr Glu Glu Glu Glu Glu Asp Glu Leu His 20 25 30 Ile Gly Arg Thr
Ala Gln Ile Gly His Val Tyr Pro Ala Ala Ile Ser 35 40 45 Asn Tyr
Asp Arg Pro Leu Trp Ala Glu Pro Cys Leu Gly Glu Thr Arg 50 55 60
Asp Leu Glu Asp Pro Ala Pro Ala Leu Lys Glu Leu Phe Val Leu Pro 65
70 75 80 Gly Glu Pro Arg Ser Gln Leu His Gln Leu Pro Lys Asn Pro
Leu Ser 85 90 95 Glu Leu Pro Val Val Lys Cys Lys Arg Val Ala Leu
Ser Leu Glu Asp 100 105 110 Asp Gly Leu Pro 115 126 97 PRT human
126 Gly Ser Leu Leu Pro Ala Leu Pro Lys Leu Pro Ser Leu Ser Ser Leu
1 5 10 15 Val Lys Pro Ser Glu Asn Gly Asn Gly Val Thr Phe Arg Ser
Gly Ala 20 25 30 Asp Leu Asn Met Asp Ile Gly Val Ser Gly Phe Gly
Pro Glu Thr Ala 35 40 45 Ile Asp Arg Ser Met Ala Met Ser Glu Asp
Phe Val Met Glu Met Gly 50 55 60 Lys Gln Pro Ile Ile Phe Glu Asn
Pro Met Tyr Ser Ala Arg Asp Ser 65 70 75 80 Ala Val Lys Val Val Gln
Pro Ile Gln Val Thr Val Ser Glu Asn Val 85 90 95 Asp 127 204 PRT
human 127 Gly Ser Leu Leu Pro Ala Leu Pro Lys Leu Pro Ser Leu Ser
Ser Leu 1 5 10 15 Val Lys Pro Ser Glu Asn Gly Asn Gly Val Thr Phe
Arg Ser Gly Ala 20 25 30 Asp Leu Asn Met Asp Ile Gly Val Ser Gly
Phe Gly Pro Glu Thr Ala 35 40 45 Ile Asp Arg Ser Met Ala Met Ser
Glu Asp Phe Val Met Glu Met Gly 50 55 60 Lys Gln Pro Ile Ile Phe
Glu Asn Pro Met Tyr Ser Ala Arg Asp Ser 65 70 75 80 Ala Val Lys Val
Val Gln Pro Ile Gln Val Thr Val Ser Glu Asn Val 85 90 95 Asp Asn
Lys Asn Tyr Gly Ser Pro Ile Asn Pro Ser Glu Ile Val Pro 100 105 110
Glu Thr Asn Pro Thr Ser Pro Ala Ala Asp Gly Thr Gln Val Thr Lys 115
120 125 Trp Asn Leu Phe Lys Arg Lys Ser Lys Gln Thr Thr Asn Phe Glu
Asn 130 135 140 Pro Ile Tyr Ala Gln Met Glu Asn Glu Gln Lys Glu Ser
Val Ala Ala 145 150 155 160 Thr Pro Pro Pro Ser Pro Ser Leu Pro Ala
Lys Pro Lys Pro Pro Ser 165 170 175 Arg Arg Asp Pro Thr Pro Thr Tyr
Ser Ala Thr Glu Asp Thr Phe Lys 180 185 190 Asp Thr Ala Asn Leu Val
Lys Glu Asp Ser Glu Val 195 200 128 103 PRT human 128 Gly Ser Pro
Ile Asn Pro Ser Glu Ile Val Pro Glu Thr Asn Pro Thr 1 5 10 15 Ser
Pro Ala Ala Asp Gly Thr Gln Val Thr Lys Trp Asn Leu Phe Lys 20 25
30 Arg Lys Ser Lys Gln Thr Thr Asn Phe Glu Asn Pro Ile Tyr Ala Gln
35 40 45 Met Glu Asn Glu Gln Lys Glu Ser Val Ala Ala Thr Pro Pro
Pro Ser 50 55 60 Pro Ser Leu Pro Ala Lys Pro Lys Pro Pro Ser Arg
Arg Asp Pro Thr 65 70 75 80 Pro Thr Tyr Ser Ala Thr Glu Asp Thr Phe
Lys Asp Thr Ala Asn Leu 85 90 95 Val Lys Glu Asp Ser Glu Val 100
129 76 PRT human 129 Val Gln Gly Ala Lys Gly Phe Gln His Gln Arg
Met Thr Asn Gly Ala 1 5 10 15 Met Asn Val Glu Ile Gly Asn Pro Thr
Tyr Lys Met Tyr Glu Gly Gly 20 25 30 Glu Pro Asp Asp Val Gly Gly
Leu Leu Asp Ala Asp Phe Ala Leu Asp 35 40 45 Pro Asp Lys Pro Thr
Asn Phe Thr Asn Pro Val Tyr Ala Thr Leu Tyr 50 55 60 Met Gly Gly
His Gly Ser Arg His Ser Leu Ala Ser 65 70 75 130 38 PRT human 130
Val Gln Gly Ala Lys Gly Phe Gln His Gln Arg Met Thr Asn Gly Ala 1 5
10 15 Met Asn Val Glu Ile Gly Asn Pro Thr Tyr Lys Met Tyr Glu Gly
Gly 20 25 30 Glu Pro Asp Asp Val Gly 35 131 68 PRT human 131 Ser
Ala Arg Asp Ser Ala Val Lys Val Val Gln Pro Ile Gln Val Thr 1 5 10
15 Val Ser Glu Asn Val Asp Asn Lys Asn Tyr Gly Ser Pro Ile Asn Pro
20 25 30 Ser Glu Ile Val Pro Glu Thr Asn Pro Thr Ser Pro Ala Ala
Asp Gly 35 40 45 Thr Gln Val Thr Lys Trp Asn Leu Phe Lys Arg Lys
Ser Lys Gln Thr 50 55 60 Thr Asn Phe Glu 65 132 97 PRT human 132
Val Gln Gly Ala Lys Gly Phe Gln His Gln Arg Met Thr Asn Gly Ala 1 5
10 15 Met Asn Val Glu Ile Gly Asn Pro Thr Tyr Lys Met Tyr Glu Gly
Gly 20 25 30 Glu Pro Asp Asp Val Gly Gly Leu Leu Asp Ala Asp Phe
Ala Leu Asp 35 40 45 Pro Asp Lys Pro Thr Asn Phe Thr Asn Pro Val
Tyr Ala Thr Leu Tyr 50 55 60 Met Gly Gly His Gly Ser Arg His Ser
Leu Ala Ser Thr Asp Glu Lys 65 70 75 80 Arg Glu Leu Leu Gly Arg Gly
Pro Glu Asp Glu Ile Gly Asp Pro Leu 85 90 95 Ala
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