U.S. patent application number 11/008743 was filed with the patent office on 2006-09-07 for derivatives of glp-1 analogs.
Invention is credited to Soren Erik Bjorn, Per Olaf Huusfeldt, Niels C. Kaarsholm, Liselotte Bjerre Knudsen, Kjeld Madsen, Per Franklin Nielsen, Helle Birk Olsen, Freddy Zimmerdahl Pedersen.
Application Number | 20060199763 11/008743 |
Document ID | / |
Family ID | 29220163 |
Filed Date | 2006-09-07 |
United States Patent
Application |
20060199763 |
Kind Code |
A1 |
Knudsen; Liselotte Bjerre ;
et al. |
September 7, 2006 |
Derivatives of GLP-1 analogs
Abstract
The present invention relates to a pharmaceutical composition
comprising a GLP-1 derivative having a lipophilic substituent; and
a surfactant.
Inventors: |
Knudsen; Liselotte Bjerre;
(Valby, DK) ; Huusfeldt; Per Olaf; (Kobenhavn K,
DK) ; Nielsen; Per Franklin; (Vaerlose, DK) ;
Kaarsholm; Niels C.; (Vanlose, DK) ; Olsen; Helle
Birk; (Allerod, DK) ; Bjorn; Soren Erik;
(Lyngby, DK) ; Pedersen; Freddy Zimmerdahl;
(Vaerlose, DK) ; Madsen; Kjeld; (Vaerlose,
DK) |
Correspondence
Address: |
Reza Green, Esq.;Novo Nordisk Pharmaceuticals, Inc.
100 College Road West
Princeton
NJ
08540
US
|
Family ID: |
29220163 |
Appl. No.: |
11/008743 |
Filed: |
December 9, 2004 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
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10285079 |
Aug 19, 2002 |
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11008743 |
Dec 9, 2004 |
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09398111 |
Sep 16, 1999 |
6458924 |
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10285079 |
Aug 19, 2002 |
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09265141 |
Mar 8, 1999 |
6384016 |
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09398111 |
Sep 16, 1999 |
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09258750 |
Feb 26, 1999 |
6268343 |
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09398111 |
Sep 16, 1999 |
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09038432 |
Mar 11, 1998 |
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09258750 |
Feb 26, 1999 |
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08918810 |
Aug 26, 1997 |
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09038432 |
Mar 11, 1998 |
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PCT/DK97/00340 |
Aug 22, 1997 |
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09038432 |
Mar 11, 1998 |
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60035904 |
Jan 24, 1997 |
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60036226 |
Jan 25, 1997 |
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60036255 |
Jan 24, 1997 |
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Current U.S.
Class: |
514/7.2 ;
514/11.7; 514/340; 514/369; 514/6.9 |
Current CPC
Class: |
A61K 38/28 20130101;
C07K 14/605 20130101; C11D 3/168 20130101; A61K 31/426 20130101;
A61K 45/06 20130101; C11D 3/0063 20130101; A61K 38/26 20130101;
A61K 2300/00 20130101; A61K 2300/00 20130101; A61K 31/4439
20130101; A61K 2300/00 20130101; A61K 2300/00 20130101; A61K
31/4439 20130101; A61K 2300/00 20130101; A61K 31/426 20130101; A61K
47/24 20130101; A61K 38/28 20130101; A61K 38/26 20130101; A61K
38/2264 20130101; A61K 38/2264 20130101 |
Class at
Publication: |
514/012 ;
514/369; 514/340 |
International
Class: |
A61K 38/22 20060101
A61K038/22; A61K 31/4439 20060101 A61K031/4439; A61K 31/426
20060101 A61K031/426 |
Foreign Application Data
Date |
Code |
Application Number |
Aug 30, 1996 |
DK |
0931/96 |
Nov 8, 1996 |
DK |
1259/96 |
Dec 20, 1996 |
DK |
1470/96 |
Feb 27, 1998 |
DK |
0263/98 |
Feb 27, 1998 |
DK |
0264/98 |
Feb 27, 1998 |
DK |
0268/98 |
Mar 13, 1998 |
EP |
98610006.3 |
Apr 8, 1998 |
DK |
PA 1998 00507 |
Feb 27, 1998 |
DK |
0272/98 |
Feb 27, 1998 |
DK |
0274/98 |
Apr 8, 1998 |
DK |
0508/98 |
Apr 8, 1998 |
DK |
0509/98 |
Claims
1. A method of treating non-insulin dependent diabetes mellitus
(NIDDM) comprising coadministering a GLP-1 molecule or an analog or
derivative thereof and a thiazolidinedione compound.
2. The method of claim 1, wherein the thiazolidinedione is
troglitazone.
3. The method of claim 1, wherein the thiazolidinedione is
ciglitazone.
4. The method of claim 1 wherein the GLP-1 molecule is GLP-1(7-36)
or GLP-1(7-37).
5. The method of claim 1 wherein the GLP-1 molecule is an analog or
derivative of
His.sup.7-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-
-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg.sup.36-X,
where X is NH.sub.2 or Gly.
6. The method of claim 5 wherein the GLP-1 molecule to be
administered is provided in a concentration of at least about 2
mg/ml.
7. The method of claim 5 wherein the GLP-1 molecule to be
administered is provided in a concentration of at least about 5
mg/ml.
8. The method of claim 5 wherein the GLP-1 molecule is to be
administered is provided in a concentration of at least about 10
mg/ml.
9. The method of claim 5 wherein the GLP-1 molecule to be
administered is provided in a concentration of at least about 2 to
about 100 mg/ml.
10. The method of claim 5 wherein the GLP-1 molecule to be
administered is provided in a concentration of at least about 5 to
about 100 mg/ml.
11. The method of claim 5 wherein the GLP-1 molecule to be
administered is provided in a concentration of at least about 10 to
about 100 mg/ml.
12. The method of claim 5, wherein the GLP-1 molecule is a GLP-1
derivative.
13. The method of claim 5, wherein the GLP-1 molecule is a GLP-1
analog.
14. The method of claim 4 wherein the GLP-1 molecule comprises
Valine, Glycine, or Threonine at position 8.
15. The method of claim 1, wherein the composition is administered
as a controlled release preparation.
16. A pharmaceutical composition comprising a GLP-1 molecule or an
analog or derivative thereof and a thiazolidinedione compound.
17. The pharmaceutical composition of claim 16 wherein the
thiazolidinedione is troglitazone.
18. The pharmaceutical composition of claim 16 wherein the
thiazolidinedione is ciglitazone.
19. The pharmaceutical composition of claim 16 wherein the GLP-1
molecule is GLP-1(7-36) or GLP-1(7-37).
20. The pharmaceutical composition of claim 16 wherein the GLP-1
molecule is an analog or derivative of
His.sup.7-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-
-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg.sup.36-X,
where X is NH.sub.2 or Gly.
21. The pharmaceutical composition of claim 20 wherein the GLP-1
molecule is a GLP-1 derivative.
22. The pharmaceutical composition of claim 20 wherein the GLP-1
molecule is a GLP-1 analog.
23. The pharmaceutical composition of claim 19 wherein the GLP-1
molecule comprises Valine, Glycine, or Threonine at position 8.
24. A composition of matter comprising: (i) a container suitable
for holding a liquid preparation to be infused in a patient; (ii) a
liquid preparation comprising a GLP-1 molecule or an analog or
derivative thereof, and a pharmaceutically acceptable carrier such
that the GLP-1 molecule or analog or derivative is present in a
concentration of at least about 2 mg/ml; and (iii) instructions on
infusing a patient with said preparation, said patient suffering
from non-insulin dependent diabetes mellitus (NIDDM), such that
said patient receives an infusion of the preparation.
25. A composition of claim 24, wherein the concentration of GLP-1
molecule or analog or derivative is at least about 5 mg/ml.
26. A composition of claim 24, wherein the concentration of GLP-1
molecule or analog or derivative is at least about 10 mg/ml.
27. A composition of claim 24, wherein the concentration of GLP-1
molecule or analog or derivative is about 2 to about 100 mg/ml.
28. A composition of claim 24, wherein the GLP-1 molecule is
GLP-1(7-36) or GLP-1(7-37).
29. A composition of claim 24, wherein the GLP-1 molecule is an
analog or derivative of
His.sup.7-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-
-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg.sup.36-X,
where X is NH.sub.2 or Gly.
30. A composition of claim 28, wherein the GLP-1 molecule comprises
Valine, Glycine or Threonine at position 8.
31. A composition of claim 24, further comprising a second
preparation comprising a thiazolidinedione compound.
32. A composition of claim 31, wherein the thiazolidinedione is
troglitazone.
33. A composition of claim 31, wherein the thiazolidinedione is
ciglitazone.
34. A composition of claim 31, wherein the GLP-1 molecule is
GLP-1(7-36) or GLP-1(7-37).
35. A composition of claim 31, wherein the GLP-1 molecule is an
analog or derivative of
His.sup.7-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-
-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg.sup.36-X,
where X is NH.sub.2 or Gly.
36. A composition of claim 34, wherein the GLP-1 molecule comprises
Valine, Glycine or Threonine at position 8.
37. A composition of claim 31, wherein the concentration of GLP-1
molecule or analog or derivative is at least about 2 mg/ml.
38. A composition of claim 31, wherein the concentration of GLP-1
molecule or analog or derivative is at about 2 to about 100 mg/ml.
Description
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This application is a continuation of Ser. No. 10/285,079,
filed Aug. 19, 2002, now pending, which is a continuation of Ser.
No. 09/398,111, filed Sep. 16, 1999, now U.S. Pat. No. 6,458,924,
which is a continuation-in-part of Ser. No. 09/265,141 filed Mar.
8, 1999 and of Ser. No. 09/258,750 filed Feb. 26, 1999, now U.S.
Pat. No. 6,268,343, which is a continuation-in-part of Ser. No.
09/038,432 filed Mar. 11, 1998, now abandoned, which is a
continuation-in-part of Ser. No. 08/918,810 filed Aug. 26, 1997,
now abandoned, and of PCT application serial no. PCT/DK97/00340
filed Aug. 22, 1997, and claims priority of U.S. provisional
application Ser. Nos. 60/035,904, 60/036,226, 60/036,255,
60/078,422, 60/082,478, 60/082,479, 60/082,480, 60/082,802, and
60/084,357 filed Jan. 24, 1997, Jan. 24, 1997, Jan. 24, 1997, Mar.
18, 1998, Apr. 21, 1998, Apr. 21, 1998, Apr. 21, 1998, Apr. 23,
1998, and May 5, 1998, respectively, and of Danish application
serial nos. 0931/96, 1259/96, 1470/96, 0263/98, 0264/98, 0268/98,
0272/98, 0274/98, 0508/98, 0509/98 and PA 1998 00507 filed Aug. 30,
1996, Nov. 8, 1996, Dec. 20, 1996, Feb. 27, 1998, Feb. 27, 1998,
Feb. 27, 1998, Feb. 27, 1998, Feb. 27, 1998, Apr. 8, 1998, Apr. 8,
1998 and Apr. 8, 1998, respectively, and of European application
no. 98610006.3 filed Mar. 13, 1998, the contents of each of which
is fully incorporated herein by reference.
FIELD OF THE INVENTION
[0002] The present invention relates to novel derivatives of human
glucagon-like peptide-1 (GLP-1) and fragments and/or analogues
thereof which have a protracted profile of action and to methods of
making and using them.
BACKGROUND OF THE INVENTION
[0003] Peptides are widely used in medical practice, and since they
can be produced by recombinant DNA technology it can be expected
that their importance will increase also in the years to come. When
native peptides or analogues thereof are used in therapy it is
generally found that they have a high clearance. A high clearance
of a therapeutic agent is inconvenient in cases where it is desired
to maintain a high blood level thereof over a prolonged period of
time since repeated administrations will then be necessary.
Examples of peptides which have a high clearance are: ACTH,
corticotropin-releasing factor, angiotensin, calcitonin, insulin,
glucagon, glucagon-like peptide-1, glucagon-like peptide-2,
insulin-like growth factor-1, insulin-like growth factor-2, gastric
inhibitory peptide, growth hormone-releasing factor, pituitary
adenylate cyclase activating peptide, secretin, enterogastrin,
somatostatin, somatotropin, somatomedin, parathyroid hormone,
thrombopoietin, erythropoietin, hypothalamic releasing factors,
prolactin, thyroid stimulating hormones, endorphins, enkephalins,
vasopressin, oxytocin, opiods and analogues thereof, superoxide
dismutase, interferon, asparaginase, arginase, arginine deaminase,
adenosine deaminase and ribonuclease. In some cases it is possible
to influence the release profile of peptides by applying suitable
pharmaceutical compositions, but this approach has various
shortcomings and is not generally applicable.
[0004] The hormones regulating insulin secretion belong to the
so-called enteroinsular axis, designating a group of hormones,
released from the gastrointestinal mucosa in response to the
presence and absorption of nutrients in the gut, which promote an
early and potentiated release of insulin. The enhancing effect on
insulin secretion, the so-called incretin effect, is probably
essential for a normal glucose tolerance. Many of the
gastrointestinal hormones, including gastrin and secretin
(cholecystokinin is not insulinotropic in man), are insulinotropic,
but the only physiologically important ones, those that are
responsible for the incretin effect, are the glucose-dependent
insulinotropic polypeptide, GIP, and glucagon-like peptide-1
(GLP-1). Because of its insulinotropic effect, GIP, isolated in
1973 (1) immediately attracted considerable interest among
diabetologists. However, numerous investigations carried out during
the following years clearly indicated that a defective secretion of
GIP was not involved in the pathogenesis of insulin dependent
diabetes mellitus (IDDM) or non insulin-dependent diabetes mellitus
(NIDDM) (2). Furthermore, as an insulinotropic hormone, GIP was
found to be almost ineffective in NIDDM (2). The other incretin
hormone, GLP-1 is the most potent insulinotropic substance known
(3). Unlike GIP, it is surprisingly effective in stimulating
insulin secretion in NIDDM patients. In addition, and in contrast
to the other insulinotropic hormones (perhaps with the exception of
secretin) it also potently inhibits glucagon secretion. Because of
these actions it has pronounced blood glucose lowering effects
particularly in patients with NIDDM.
[0005] GLP-1, a product of the proglucagon (4), is one of the
youngest members of the secretin-VIP family of peptides, but is
already established as an important gut hormone with regulatory
function in glucose metabolism and gastrointestinal secretion and
metabolism (5). The glucagon gene is processed differently in the
pancreas and in the intestine. In the pancreas (9), the processing
leads to the formation and parallel secretion of 1) glucagon
itself, occupying positions 33-61 of proglucagon (PG); 2) an
N-terminal peptide of 30 amino acids (PG (1-30)) often called
glicentin-related pancreatic peptide, GRPP (10, 11); 3) a
hexapeptide corresponding to PG (64-69); 4) and, finally, the
so-called major proglucagon fragment (PG (72-158)), in which the
two glucagon-like sequences are buried (9). Glucagon seems to be
the only biologically active product. In contrast, in the
intestinal mucosa, it is glucagon that is buried in a larger
molecule, while the two glucagon-like peptides are formed
separately (8). The following products are formed and secreted in
parallel: 1) glicentin, corresponding to PG (1-69), with the
glucagon sequence occupying residues Nos. 33-61 (12); 2)
GLP-1(7-36)amide (PG (78-107))amide (13), not as originally
believed PG (72-107)amide or 108, which is inactive). Small amounts
of C-terminally glycine-extended but equally bioactive GLP-1(7-37),
(PG (78-108)) are also formed (14); 3) intervening peptide-2 (PG
(111-122)amide) (15); and 4) GLP-2 (PG (126-158)) (15, 16). A
fraction of glicentin is cleaved further into GRPP (PG (1-30)) and
oxyntomodulin (PG (33-69)) (17, 18). Of these peptides, GLP-1, has
the most conspicuous biological activities.
[0006] Being secreted in parallel with glicentin/enteroglucagon, it
follows that the many studies of enteroglucagon secretion (6, 7) to
some extent also apply to GLP-1 secretion, but GLP-1 is metabolised
more quickly with a plasma half-life in humans of 2 min (19).
Carbohydrate or fat-rich meals stimulate secretion (20), presumably
as a result of direct interaction of yet unabsorbed nutrients with
the microvilli of the open-type L-cells of the gut mucosa.
Endocrine or neural mechanisms promoting GLP-1 secretion may exist
but have not yet been demonstrated in humans.
[0007] The incretin function of GLP-1(29-31) has been clearly
illustrated in experiments with the GLP-1 receptor antagonist,
exendin 9-39, which dramatically reduces the incretin effect
elicited by oral glucose in rats (21, 22). The hormone interacts
directly with the ?-cells via the GLP-1 receptor (23) which belongs
to the glucagon/VIP/calcitonin family of G-protein-coupled
7-transmembrane spanning receptors. The importance of the GLP-1
receptor in regulating insulin secretion was illustrated in recent
experiments in which a targeted disruption of the GLP-1 receptor
gene was carried out in mice. Animals homozygous for the disruption
had greatly deteriorated glucose tolerance and fasting
hyperglycaemia, and even heterozygous animals were glucose
intolerant (24). The signal transduction mechanism (25) primarily
involves activation of adenylate cyclase, but elevations of
intracellular Ca.sup.2+ are also essential (25, 26). The action of
the hormone is best described as a potentiation of glucose
stimulated insulin release (25), but the mechanism that couples
glucose and GLP-1 stimulation is not known. It may involve a
calcium-induced calcium release (26, 27). As already mentioned, the
insulinotropic action of GLP-1 is preserved in diabetic ?-cells.
The relation of the latter to its ability to convey "glucose
competence" to isolated insulin-secreting cells (26, 28), which
respond poorly to glucose or GLP-1 alone, but fully to a
combination of the two, is also not known. Equally importantly,
however, the hormone also potently inhibits glucagon secretion
(29). The mechanism is not known, but seems to be paracrine, via
neighbouring insulin or somatostatin cells (25). Also the
glucagonostatic action is glucose-dependent, so that the inhibitory
effect decreases as blood glucose decreases. Because of this dual
effect, if the plasma GLP-1 concentrations increase either by
increased secretion or by exogenous infusion the molar ratio of
insulin to glucagon in the blood that reaches the liver via the
portal circulation is greatly increased, whereby hepatic glucose
production decreases (30). As a result blood glucose concentrations
decrease. Because of the glucose dependency of the insulinotropic
and glucagonostatic actions, the glucose lowering effect is
self-limiting, and the hormone, therefore, does not cause
hypoglycaemia regardless of dose (31). The effects are preserved in
patients with diabetes mellitus (32), in whom infusions of slightly
supraphysiological doses of GLP-1 may completely normalise blood
glucose values in spite of poor metabolic control and secondary
failure to sulphonylurea (33). The importance of the
glucagonostatic effect is illustrated by the finding that GLP-1
also lowers blood glucose in type-I diabetic patients without
residual ?-cell secretory capacity (34).
[0008] In addition to its effects on the pancreatic islets, GLP-1
has powerful actions on the gastrointestinal tract. Infused in
physiological amounts, GLP-1 potently inhibits pentagastrin-induced
as well as meal-induced gastric acid secretion (35, 36). It also
inhibits gastric emptying rate and pancreatic enzyme secretion
(36). Similar inhibitory effects on gastric and pancreatic
secretion and motility may be elicited in humans upon perfusion of
the ileum with carbohydrate- or lipid-containing solutions (37,
38). Concomitantly, GLP-1 secretion is greatly stimulated, and it
has been speculated that GLP-1 may be at least partly responsible
for this so-called "ileal-brake" effect (38). In fact, recent
studies suggest that, physiologically, the ileal-brake effects of
GLP-1 may be more important than its effects on the pancreatic
islets. Thus, in dose response studies GLP-1 influences gastric
emptying rate at infusion rates at least as low as those required
to influence islet secretion (39).
[0009] GLP-1 seems to have an effect on food intake.
Intraventricular administration of GLP-1 profoundly inhibits food
intake in rats (40, 42). This effect seems to be highly specific.
Thus, N-terminally extended GLP-1 (PG 72-107)amide is inactive and
appropriate doses of the GLP-1 antagonist, exendin 9-39, abolish
the effects of GLP-1(41). Acute, peripheral administration of GLP-1
does not inhibit food intake acutely in rats (41, 42). However, it
remains possible that GLP-1 secreted from the intestinal L-cells
may also act as a satiety signal.
[0010] Not only the insulinotropic effects but also the effects of
GLP-1 on the gastrointestinal tract are preserved in diabetic
patients (43), and may help curtailing meal-induced glucose
excursions, but, more importantly, may also influence food intake.
Administered intravenously, continuously for one week, GLP-1 at 4
ng/kg/min has been demonstrated to dramatically improve glycaemic
control in NIDDM patients without significant side effects (44).
The peptide is fully active after subcutaneous administration (45),
but is rapidly degraded mainly due to degradation by dipeptidyl
peptidase IV-like enzymes (46, 47).
[0011] The amino acid sequence of GLP-1 is given i.a. by Schmidt et
al. (Diabetologia 28 704-707 (1985). Human GLP-1 is a 37 amino acid
residue peptide originating from preproglucagon which is
synthesised, i.a. in the L-cells in the distal ileum, in the
pancreas and in the brain. Processing of preproglucagon to
GLP-1(7-36)amide, GLP-1(7-37) and GLP-2 occurs mainly in the
L-cells. Although the interesting pharmacological properties of
GLP-1(7-37) and analogues thereof have attracted much attention in
recent years only little is known about the structure of these
molecules. The secondary structure of GLP-1 in micelles has been
described by Thorton et al. (Biochemistry 33 3532-3539 (1994)), but
in normal solution, GLP-1 is considered a very flexible molecule.
Surprisingly, we found that derivatisation of this relatively small
and very flexible molecule resulted in compounds whose plasma
profile were highly protracted and still had retained activity.
[0012] GLP-1 and analogues of GLP-1 and fragments thereof are
useful i.a. in the treatment of Type 1 and Type 2 diabetes and
obesity.
[0013] WO 87/06941 discloses GLP-1 fragments, including
GLP-1(7-37), and functional derivatives thereof and to their use as
an insulinotropic agent.
[0014] WO 90/11296 discloses GLP-1 fragments, including
GLP-1(7-36), and functional derivatives thereof which have an
insulinotropic activity which exceeds the insulinotropic activity
of GLP-1(1-36) or GLP-1(1-37) and to their use as insulinotropic
agents.
[0015] The amino acid sequence of GLP-1(7-36) and GLP-1(7-37) is
(SEQ ID NO:1): TABLE-US-00001 7 8 9 10 11 12 13 14 15 16 17
His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser- 18 19 20 21 22 23 24
25 26 27 28 Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe- 29 30 31
32 33 34 35 36 Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-X (I)
wherein X is NH.sub.2 for GLP-1(7-36) and X is Gly for
GLP-1(7-37).
[0016] WO 91/11457 discloses analogues of the active GLP-1 peptides
7-34, 7-35, 7-36, and 7-37 which can also be useful as GLP-1
moieties.
[0017] EP 0708179-A2 (Eli Lilly & Co.) discloses GLP-1
analogues and derivatives that include an N-terminal imidazole
group and optionally an unbranched C.sub.6-C.sub.10 acyl group in
attached to the lysine residue in position 34.
[0018] EP 0699686-A2 (Eli Lilly & Co.) discloses certain
N-terminal truncated fragments of GLP-1 that are reported to be
biologically active.
[0019] Unfortunately, the high clearance limits the usefulness of
these compounds. Thus there still is a need for improvements in
this field.
[0020] Accordingly, it is an object of the present invention to
provide derivatives of GLP-1 and analogues thereof which have a
protracted profile of action relative to GLP-1(7-37).
[0021] It is a further object of the invention to provide
derivatives of GLP-1 and analogues thereof which have a lower
clearance than GLP-1(7-37).
[0022] It is a further object of the invention to provide a
pharmaceutical composition with improved solubility and
stability.
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Harling H, & Hoist J J: Naturally occurring products of
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Rabenhoj L, Kofod H, Hoist J J: Carboxypeptidase-B-like processing
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biological effects of GLP-1 7-36 amide and GLP-1 7-37 in healthy
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Goke R, Goke B. Reduction of the incretin effect in rats by the
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Auerbach A B, Joyner A L, Drucker D J. Diabetes in mice with
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biology of the incretin hormones glucagon-like peptide-I (GLP-1)
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S, Bokvist K, Renstrom E, Frokjaer-Jensen J, Wulff B S, Rorsman P.
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mellitus. J Clin Invest 1993; 91:301-307. [0055] 33. Nauck M A,
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amide) in type 2-diabetic patients. Diabetologia 1993; 36:741-744.
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Holst J J. GLP-1 (glucagon-like peptide-1) and truncated GLP-1,
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Schjoldager B, Mortensen P E, Myhre J, Christiansen J, Holst J J.
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humans? Digestion 1993; 54: 385-386. [0061] 39. Nauck M, Ettler R,
Niedereichholz U, Orskov C, Holst J J, Schmiegel W. Inhibition of
gastric emptying by GLP-1(7-36 amide) or (7-37): effects on
postprandial glycaemia and insulin secretion. Abstract. Gut 1995;
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Zimmermann J P, Schusdziarra V, Classen M. Glucagon-like peptide
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Orskov C, Holst J J, Nauck M. Inhibition of gastric emptying by
glucagon-like peptide-1 (7-36 amide) in patients with
type-2-diabetes mellitus. Diabetologia 1994; 37, suppl.1: A118.
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infusion of GLP-1(7-37) improves glycaemic control in NIDDM.
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Holst J J, Nauck M A. Pharmacokinetic, insulinotropic, and
glucagonostatic properties of GLP-1 [7-36 amide] after subcutaneous
injection in healthy volunteers. Dose-response relationships.
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Holst J J. Degradation of glucagon-like peptide-1 by human plasma
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administered glucagon-like peptide-1 are rapidly degraded from the
amino terminus in type II diabetic patients and in healthy
subjects. Diabetes 44: 1126-1131.
SUMMARY OF THE INVENTION
[0070] The present invention relates to a pharmaceutical
composition with improved solubility and stability comprising
derivatives of GLP-1(1-45) and analogs and/or fragments thereof.
The GLP-1 derivatives of the present invention have interesting
pharmacological properites, in particular they have a more
protracted profile of action than the parent peptides. The GLP-1
derivatives of the present invention also have insulinotropic
activity, ability to decrease glucagon, ability to suppress gastric
motility, ability to restore glucose competency to beta-cells,
and/or ability to suppress appetite/reduce weight.
BRIEF DESCRIPTION OF THE FIGURES
[0071] FIG. 1 shows the results of Circular Dichroism (CD) at 222
nm as a function of peptide concentration for native GLP-1(7-37)
and various GLP-1 derivatives of the present invention.
DETAILED DESCRIPTION OF THE INVENTION
[0072] A simple system is used to describe fragments and analogues
of GLP-1. For example, Gly.sup.8-GLP-1(7-37) designates a peptide
which relates to GLP-1 by the deletion of the amino acid residues
at positions. 1 to 6 and substituting the naturally occurring amino
acid residue in position 8 (Ala) by Gly. Similarly,
Lys.sup.34(N.sup.?-tetradecanoyl)-GLP-1(7-37) designates
GLP-1(7-37) wherein the ?-amino group of the Lys residue in
position 34 has been tetradecanoylated. Where reference in this
text is made to C-terminally extended GLP-1 analogues, the amino
acid residue in position 38 is Arg unless otherwise indicated, the
amino acid residue in position 39 is also Arg unless otherwise
indicated and the optional amino acid residue in position 40 is Asp
unless otherwise indicated. Also, if a C-terminally extended
analogue extends to position 41, 42, 43, 44 or 45, the amino acid
sequence of this extension is as in the corresponding sequence in
human preproglucagon unless otherwise indicated.
GLP-1 Analogs
[0073] The term "an analogue" is defined herein as a peptide
wherein one or more amino acid residues of the parent peptide have
been substituted by another amino acid residue. In a preferred
embodiment, the total number of different amino acids between the
GLP-1 derivative and the corresponding native form of GLP-1 is up
to fifteen, preferably up to ten amino acid residues, and most
preferably up to six amino acid residues.
[0074] The total number of different amino acids between the
derivative of the GLP-1 analog and the corresponding native form of
GLP-1 preferably does not exceed six. Preferably, the number of
different amino acids is five. More preferably, the number of
different amino acids is four. Even more preferably, the number of
different amino acids is three. Even more preferably, the number of
different amino acids is two. Most preferably, the number of
different amino acids is one. In order to determine the number of
different amino acids, one should compare the amino acid sequence
of the GLP-1 derivative of the present invention with the
corresponding native GLP-1. For example, there are two different
amino acids between the derivative
Gly.sup.8Arg.sup.26Lys.sup.34(N.sup.?-(7-deoxycholoyl))-GLP-1(7-40)
and the corresponding native GLP-1 (i.e., GLP-1(7-40)). The
differences are located at positions 8 and 26. Similarly, there is
only one different amino acid between the derivative
Lys.sup.26(N.sup.?-(7-deoxycholoyl))Arg.sup.34-GLP-1(7-40) and the
corresponding native GLP-1. The difference is located at position
34.
[0075] In a preferred embodiment, the present invention relates to
a GLP-1 derivative wherein the parent peptide is GLP-1(1-45) or an
analogue thereof. In a further preferred embodiment, the parent
peptide is GLP-1(1-35), GLP-1(1-36), GLP-1(1-36)amide, GLP-1(1-37),
GLP-1(1-38), GLP-1(1-39), GLP-1(140), GLP-1(1-41) or an analogue
thereof.
[0076] In a preferred embodiment, the present invention relates to
derivatives of GLP-1 analogues of formula I (SEQ ID NO:2):
TABLE-US-00002 7 8 9 10 11 12 13 14 15 16 17
Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa- 18 19 20 21 22 23 24
25 26 27 28 Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Phe- 29 30 31
32 33 34 35 36 37 38 Ile-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa 39 40
41 42 43 44 45 Xaa-Xaa-Xaa-Xaa-Xaa-Xaa-Xaa (I)
wherein
[0077] Xaa at position 7 is His, a modified amino acid or is
deleted,
[0078] Xaa at position 8 is Ala, Gly, Ser, Thr, Leu, Ile, Val, Glu,
Asp, or Lys, or is deleted,
[0079] Xaa at position 9 is Glu, Asp, or Lys, or is deleted,
[0080] Xaa at position 10 is Gly or is deleted,
[0081] Xaa at position 11 is Thr, Ala, Gly, Ser, Leu, Ile, Val,
Glu, Asp, or Lys, or is deleted,
[0082] Xaa at position 12 is Phe or is deleted,
[0083] Xaa at position 13 is Thr or is deleted,
[0084] Xaa at position 14 is Ser, Ala, Gly, Thr, Leu, Ile, Val,
Glu, Asp, or Lys, or is deleted,
[0085] Xaa at position 15 is Asp or is deleted,
[0086] Xaa at position 16 is Val, Ala, Gly, Ser, Thr, Leu, Ile,
Tyr, Glu, Asp, or Lys, or is deleted,
[0087] Xaa at position 17 is Ser, Ala, Gly, Thr, Leu, Ile, Val,
Glu, Asp, or Lys, or is deleted,
[0088] Xaa at position 18 is Ser, Ala, Gly, Thr, Leu, Ile, Val,
Glu, Asp, or Lys,
[0089] Xaa at position 19 is Tyr, Phe, Trp, Glu, Asp, or Lys,
[0090] Xaa at position 20 is Leu, Ala, Gly, Ser, Thr, Leu, Ile,
Val, Glu, Asp, or Lys,
[0091] Xaa at position 21 is Glu, Asp, or Lys,
[0092] Xaa at position 22 is Gly, Ala, Ser, Thr, Leu, Ile, Val,
Glu, Asp, or Lys,
[0093] Xaa at position 23 is Gln, Asn, Arg, Glu, Asp, or Lys,
[0094] Xaa at position 24 is Ala, Gly, Ser, Thr, Leu, Ile, Val,
Arg, Glu, Asp, or Lys,
[0095] Xaa at position 25 is Ala, Gly, Ser, Thr, Leu, Ile, Val,
Glu, Asp, or Lys,
[0096] Xaa at position 26 is Lys, Arg, Gln, Glu, Asp, or His,
[0097] Xaa at position 27 is Glu, Asp, or Lys,
[0098] Xaa at position 30 is Ala, Gly, Ser, Thr, Leu, Ile, Val,
Glu, Asp, or Lys,
[0099] Xaa at position 31 is Trp, Phe, Tyr, Glu, Asp, or Lys,
[0100] Xaa at position 32 is Leu, Gly, Ala, Ser, Thr, Ile, Val,
Glu, Asp, or Lys,
[0101] Xaa at position 33 is Val, Gly, Ala, Ser, Thr, Leu, Ile,
Glu, Asp, or Lys,
[0102] Xaa at position 34 is Lys, Arg, Glu, Asp, or His,
[0103] Xaa at position 35 is Gly, Ala, Ser, Thr, Leu, Ile, Val,
Glu, Asp, or Lys,
[0104] Xaa at position 36 is Arg, Lys, Glu, Asp, or His,
[0105] Xaa at position 37 is Gly, Ala, Ser, Thr, Leu, Ile, Val,
Glu, Asp, or Lys, or is deleted,
[0106] Xaa at position 38 is Arg, Lys, Glu, Asp, or His, or is
deleted,
[0107] Xaa at position 39 is Arg, Lys, Glu, Asp, or His, or is
deleted,
[0108] Xaa at position 40 is Asp, Glu, or Lys, or is deleted,
[0109] Xaa at position 41 is Phe, Trp, Tyr, Glu, Asp, or Lys, or is
deleted,
[0110] Xaa at position 42 is Pro, Lys, Glu, or Asp, or is
deleted,
[0111] Xaa at position 43 is Glu, Asp, or Lys, or is deleted,
[0112] Xaa at position 44 is Glu, Asp, or Lys, or is deleted,
and
[0113] Xaa at position 45 is Val, Glu, Asp, or Lys, or is deleted,
or
(a) a C-1-6-ester thereof, (b) amide, C-1-6-alkylamide, or
C-1-6-dialkylamide thereof and/or (c) a pharmaceutically acceptable
salt thereof,
[0114] provided that when the amino acid at position 37, 38, 39,
40, 41, 42, 43 or 44 is deleted, then each amino acid downstream of
the amino acid is also deleted and when the amino acid at position
8, 9, 10, 11, 12, 13, 14, 15, 16 or 17 is deleted then each amino
acid upstream of the amino acid is also deleted.
[0115] The term "modified amino acid" is defined herein as A is:
##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are independently H,
lower alkyl, optionally substituted phenyl, NH.sub.2, NH--CO-(lower
alkyl), --OH, lower alkoxy, halogen, SO.sub.2-- (lower alkyl) or
CF.sub.3, wherein said phenyl is optionally substituted with at
least one group selected from NH.sub.2, --OH, lower alkyl or lower
alkoxy having 1-6 carbon atoms, halogen, SO.sub.2-(lower alkyl),
NH--CO-(lower alkyl) or CF.sub.3, or R.sup.1 and R.sup.2 may
together form a bond; and Y is a five or six membered ring system
selected from the group consisting of: ##STR2## wherein Z is N, O
or S, and said ring system is optionally substituted with one or
more functional groups selected from the group consisting of
NH.sub.2, NO.sub.2, OH, lower alkyl, lower alkoxy, halogen,
CF.sub.3 and aryl (i.e., optionally substituted phenyl, as define
above), provided that A is not histidine;
[0116] The terms "lower alkyl" and "lower alkoxy" refer to an alkyl
or alkoxy group, respectively, having 1-6 carbon atoms.
[0117] In a preferred embodiment, A is: ##STR3##
[0118] In another preferred embodiment, A is: ##STR4##
[0119] In another prefer-red embodiment, A is: ##STR5##
[0120] In another preferred embodiment, A is: ##STR6##
[0121] In another preferred embodiment, A is: ##STR7##
[0122] In another preferred embodiment, A is
4-imidazopropionyl.
[0123] In another preferred embodiment, A is 4-imidazoacetyl.
[0124] In another preferred embodiment, A is
4-imidazo-.alpha.,.alpha.-dimethyl-acetyl.
[0125] The GLP-1 derivatives of the present invention preferably
have only one or two Lys wherein the .epsilon.-amino group of one
or both Lys is substituted with a lipophilic substituent.
Preferably, the GLP-1 derivatives of the present invention have
only one Lys. In a more preferred embodiment, there is only one Lys
which is located at the carboxy terminus of the derivative of the
GLP-1 analogs. In an even more preferred embodiment, the GLP-1
derivatives of the present invention have only one Lys and Glu or
Asp is adjacent to Lys.
[0126] In a preferred embodiment, the amino acids at positions
37-45 are absent.
[0127] In another preferred embodiment, the amino acids at
positions 38-45 are absent.
[0128] In another preferred embodiment, the amino acids at
positions 39-45 are absent.
[0129] In another preferred embodiment, the amino acid at position
7 is deleted.
[0130] In another preferred embodiment, the amino acids at
positions 7 and 8 are deleted.
[0131] In another preferred embodiment, the amino acids at
positions 7-9 are deleted.
[0132] In another preferred embodiment, the amino acids at
positions 7-10 are deleted.
[0133] In another preferred embodiment, the amino acids at
positions 7-11 are deleted.
[0134] In another preferred embodiment, the amino acids at
positions 7-12 are deleted.
[0135] In another preferred embodiment, the amino acids at
positions 7-13 are deleted.
[0136] In another preferred embodiment, the amino acids at
positions 7-14 are deleted.
[0137] In another preferred embodiment, the amino acids at
positions 7-15 are deleted.
[0138] In another preferred embodiment, the amino acids at
positions 7-16 are deleted.
[0139] In another preferred embodiment, the amino acids at
positions 7-17 are deleted.
[0140] In another preferred embodiment, Xaa at position 7 is
His.
[0141] In another preferred embodiment, Xaa at position 8 is Ala,
Gly, Ser, Thr, or Val.
[0142] In another preferred embodiment, Xaa at position 9 is
Glu.
[0143] In another preferred embodiment, Xaa at position 10 is
Gly.
[0144] In another preferred embodiment, Xaa at position 11 is
Thr.
[0145] In another preferred embodiment, Xaa at position 12 is
Phe.
[0146] In another preferred embodiment, Xaa at position 13 is
Thr.
[0147] In another preferred embodiment, Xaa at position 14 is
Ser.
[0148] In another preferred embodiment, Xaa at position 15 is
Asp.
[0149] In another preferred embodiment, Xaa at position 16 is
Val.
[0150] In another preferred embodiment, Xaa at position 17 is
Ser.
[0151] In another preferred embodiment, Xaa at position 18 is Ser,
Lys, Glu, or Asp.
[0152] In another preferred embodiment, Xaa at position 19 is Tyr,
Lys, Glu, or Asp.
[0153] In another preferred embodiment, Xaa at position 20 is Leu,
Lys, Glu, or Asp.
[0154] In another preferred embodiment, Xaa at position 21 is Glu,
Lys, or Asp.
[0155] In another preferred embodiment, Xaa at position 22 is Gly,
Glu, Asp, or Lys.
[0156] In another preferred embodiment, Xaa at position 23 is Gln,
Glu, Asp, or Lys.
[0157] In another preferred embodiment, Xaa at position 24 is Ala,
Glu, Asp, or Lys.
[0158] In another preferred embodiment, Xaa at position 25 is Ala,
Glu, Asp, or Lys.
[0159] In another preferred embodiment, Xaa at position 26 is Lys,
Glu, Asp, or Arg.
[0160] In another preferred embodiment, Xaa at position 27 is Glu,
Asp, or Lys.
[0161] In another preferred embodiment, Xaa at position 30 is Ala,
Glu, Asp, or Lys.
[0162] In another preferred embodiment, Xaa at position 31 is Trp,
Glu, Asp, or Lys.
[0163] In another preferred embodiment, Xaa at position 32 is Leu,
Glu, Asp, or Lys.
[0164] In another preferred embodiment, Xaa at position 33 is Val,
Glu, Asp, or Lys.
[0165] In another preferred embodiment, Xaa at position 34 is Lys,
Arg, Glu, or Asp.
[0166] In another preferred embodiment, Xaa at position 35 is Gly,
Glu, Asp, or Lys.
[0167] In another preferred embodiment, Xaa at position 36 is Arg,
Lys, Glu, or Asp.
[0168] In another preferred embodiment, Xaa at position 37 is Gly,
Glu, Asp, or Lys.
[0169] In another preferred embodiment, Xaa at position 38 is Arg
or Lys, or is deleted.
[0170] In another preferred embodiment, Xaa at position 39 is
deleted.
[0171] In another preferred embodiment, Xaa at position 40 is
deleted.
[0172] In another preferred embodiment, Xaa at position 41 is
deleted.
[0173] In another preferred embodiment, Xaa at position 42 is
deleted.
[0174] In another preferred embodiment, Xaa at position 43 is
deleted.
[0175] In another preferred embodiment, Xaa at position 44 is
deleted.
[0176] In another preferred embodiment, Xaa at position 45 is
deleted.
[0177] In another preferred embodiment, Xaa at position 26 is Arg,
each of Xaa at positions 37-45 is deleted, and each of the other
Xaa is the amino acid in native GLP-1(7-36).
[0178] In another preferred embodiment, Xaa at position 26 is Arg,
each of Xaa at positions 38-45 is deleted, and each of the other
Xaa is the amino acid in native GLP-1(7-37).
[0179] In another preferred embodiment, Xaa at position 26 is Arg,
each of Xaa at positions 39-45 is deleted, and each of the other
Xaa is the amino acid in native GLP-1(7-38).
[0180] In another preferred embodiment, Xaa at position 34 is Arg,
each of Xaa at positions 37-45 is deleted, and each of the other
Xaa is the amino acid in native GLP-1(7-36).
[0181] In another preferred embodiment, Xaa at position 34 is Arg,
each of Xaa at positions 38-45 is deleted, and each of the other
Xaa is the amino acid in native GLP-1(7-37).
[0182] In another preferred embodiment, Xaa at position 34 is Arg,
each of Xaa at positions 39-45 is deleted, and each of the other
Xaa is the amino acid in native GLP-1(7-38).
[0183] In another preferred embodiment, Xaa at positions 26 and 34
is Arg, Xaa at position 36 is Lys, each of Xaa at positions 37-45
is deleted, and each of the other Xaa is the amino acid in native
GLP-1(7-36).
[0184] In another preferred embodiment, Xaa at positions 26 and 34
is Arg, Xaa at position 36 is Lys, each of Xaa at positions 38-45
is deleted, and each of the other Xaa is the amino acid in native
GLP-1(7-37).
[0185] In another preferred embodiment, Xaa at positions 26 and 34
is Arg, Xaa at position 36 is Lys, each of Xaa at positions 39-45
is deleted, and each of the other Xaa is the amino acid in native
GLP-1(7-38).
[0186] In another preferred embodiment, Xaa at positions 26 and 34
is Arg, Xaa at position 38 is Lys, each of Xaa at positions 39-45
is deleted, and each of the other Xaa is the amino acid in native
GLP-1(7-38).
[0187] In another preferred embodiment, Xaa at position 8 is Thr,
Ser, Gly or Val, Xaa at position 37 is Asp or Glu, Xaa at position
36 is Lys, each of Xaa at positions 38-45 is deleted, and each of
the other Xaa is the amino acid in native GLP-1(7-37).
[0188] In another preferred embodiment, Xaa at position 8 is Thr,
Ser, Gly or Val, Xaa at position 37 is Asp or Glu, Xaa at position
36 is Lys, each of Xaa at positions 39-45 is deleted, and each of
the other Xaa is the amino acid in native GLP-1(7-38).
[0189] In another preferred embodiment, Xaa at position 8 is Thr,
Ser, Gly or Val, Xaa at position 36 is Lys, each of Xaa at
positions 37-45 is deleted, and each of the other Xaa is the amino
acid in native GLP-1(7-36).
[0190] In another preferred embodiment, Xaa at position 8 is Thr,
Ser, Gly or Val, Xaa at position 36 is Lys, each of Xaa at
positions 38-45 is deleted, and each of the other Xaa is the amino
acid in native GLP-1(7-37).
[0191] In another preferred embodiment, Xaa at position 8 is Thr,
Ser, Gly or Val, Xaa at position 36 is Lys, each of Xaa at
positions 39-45 is deleted, and each of the other Xaa is the amino
acid in native GLP-1(7-38).
[0192] In another preferred embodiment, Xaa at position 8 is Thr,
Ser, Gly or Val, Xaa at position 37 is Glu or Asp, Xaa at position
38 is Lys, each of Xaa at positions 39-45 is deleted, and each of
the other Xaa is the amino acid in native GLP-1(7-38).
[0193] In another preferred embodiment, Xaa at position 8 is Thr,
Ser, Gly or Val, Xaa at position 38 is Lys, each of Xaa at
positions 39-45 is deleted, and each of the other Xaa is the amino
acid in native GLP-1(7-38).
[0194] In another preferred embodiment, Xaa at position 18, 23 or
27 is Lys, and Xaa at positions 26 and 34 is Arg, each of Xaa at
positions 37-45 is deleted, and each of the other Xaa is the amino
acid in native GLP-1(7-36).
[0195] In another preferred embodiment, Xaa at position 18, 23 or
27 is Lys, and Xaa at positions 26 and 34 is Arg, each of Xaa at
positions 38-45 is deleted, and each of the other Xaa is the amino
acid in native GLP-1(7-37).
[0196] In another preferred embodiment, Xaa at position 18, 23 or
27 is Lys, and Xaa at positions 26 and 34 is Arg, each of Xaa at
positions 39-45 is deleted, and each of the other Xaa is the amino
acid in native GLP-1(7-38).
[0197] In another preferred embodiment, Xaa at position 8 is Thr,
Ser, Gly, or Val, Xaa at position 18, 23 or 27 is Lys, and Xaa at
position 26 and 34 is Arg, each of Xaa at positions 37-45 is
deleted, and each of the other Xaa is the amino acid in native
GLP-1(7-36).
[0198] In another preferred embodiment, Xaa at position 8 is Thr,
Ser, Gly, or Val, Xaa at position 18, 23 or 27 is Lys, and Xaa at
position 26 and 34 is Arg, each of Xaa at positions 38-45 is
deleted, and each of the other Xaa is the amino acid in native
GLP-1(7-37).
[0199] In another preferred embodiment, Xaa at position 8 is Thr,
Ser, Gly, or Val, Xaa at position 18, 23 or 27 is Lys, and Xaa at
position 26 and 34 is Arg, each of Xaa at positions 39-45 is
deleted, and each of the other Xaa is the amino acid in native
GLP-1(7-38).
[0200] In another preferred embodiment, Xaa at position 7 is a
modified amino acid or is deleted, Xaa at position 26 is Arg, each
of Xaa at positions 37-45 is deleted, and each of the other Xaa is
the amino acid in native GLP-1(8-36).
[0201] In another preferred embodiment, Xaa at position 7 is a
modified amino acid or is deleted, Xaa at position 26 is Arg, each
of Xaa at positions 38-45 is deleted, and each of the other Xaa is
the amino acid in native GLP-1(8-37).
[0202] In another preferred embodiment, Xaa at position 7 is a
modified amino acid or is deleted, Xaa at position 26 is Arg, each
of Xaa at positions 39-45 is deleted, and each of the other Xaa is
the amino acid in native GLP-1(8-38).
[0203] In another preferred embodiment, Xaa at position 7 is a
modified amino acid or is deleted, Xaa at position 34 is Arg, each
of Xaa at positions 37-45 is deleted, and each of the other Xaa is
the amino acid in native GLP-1(8-36).
[0204] In another preferred embodiment, Xaa at position 7 is a
modified amino acid or is deleted, Xaa at position 34 is Arg, each
of Xaa at positions 38-45 is deleted, and each of the other Xaa is
the amino acid in native GLP-1(8-37).
[0205] In another preferred embodiment, Xaa at position 7 is a
modified amino acid or is deleted, Xaa at position 34 is Arg, each
of Xaa at positions 39-45 is deleted, and each of the other Xaa is
the amino acid in native GLP-1(8-38).
[0206] In another preferred embodiment, Xaa at position 7 is a
modified amino acid or is deleted, Xaa at positions 26 and 34 is
Arg, Xaa at position 36 is Lys, each of Xaa at positions 37-45 is
deleted, and each of the other Xaa is the amino acid in native
GLP-1(8-36).
[0207] In another preferred embodiment, Xaa at position 7 is a
modified amino acid or is deleted, Xaa at positions 26 and 34 is
Arg, Xaa at position 36 is Lys, each of Xaa at positions 38-45 is
deleted, and each of the other Xaa is the amino acid in native
GLP-1(8-37).
[0208] In another preferred embodiment, Xaa at position 7 is a
modified amino acid or is deleted, Xaa at positions 26 and 34 is
Arg, Xaa at position 36 is Lys, each of Xaa at positions 39-45 is
deleted, and each of the other Xaa is the amino acid in native
GLP-1(8-38).
[0209] In another preferred embodiment, Xaa at position 7 is a
modified amino acid or is deleted, Xaa at positions 26 and 34 is
Arg, Xaa at position 38 is Lys, each of Xaa at positions 39-45 is
deleted, and each of the other Xaa is the amino acid in native
GLP-1(8-38).
[0210] In another preferred embodiment, Xaa at position 7 is a
modified amino acid or is deleted, Xaa at position 8 is Thr, Ser,
Gly or Val, Xaa at position 37 is Glu, Xaa at position 36 is Lys,
each of Xaa at positions 38-45 is deleted, and each of the other
Xaa is the amino acid in native GLP-1(8-37).
[0211] In another preferred embodiment, Xaa at position 7 is a
modified amino acid or is deleted, Xaa at position 8 is Thr, Ser,
Gly or Val, Xaa at position 37 is Glu, Xaa at position 36 is Lys,
each of Xaa at positions 39-45 is deleted, and each of the other
Xaa is the amino acid in native GLP-1(8-38).
[0212] In another preferred embodiment, Xaa at position 7 is a
modified amino acid or is deleted, Xaa at position 8 is Thr, Ser,
Gly or Val, Xaa at position 37 is Glu, Xaa at position 38 is Lys,
each of Xaa at positions 39-45 is deleted, and each of the other
Xaa is the amino acid in native GLP-1(8-38).
[0213] In another preferred embodiment, Xaa at position 7 is a
modified amino acid or is deleted, Xaa at position 18, 23 or 27 is
Lys, and Xaa at positions 26 and 34 is Arg, each of Xaa at
positions 37-45 is deleted, and each of the other Xaa is the amino
acid in native GLP-1(8-36).
[0214] In another preferred embodiment, Xaa at position 7 is a
modified amino acid or is deleted, Xaa at position 18, 23 or 27 is
Lys, and Xaa at positions 26 and 34 is Arg, each of Xaa at
positions 38-45 is deleted, and each of the other Xaa is the amino
acid in native GLP-1(8-37).
[0215] In another preferred embodiment, Xaa at position 7 is a
modified amino acid or is deleted, Xaa at position 18, 23 or 27 is
Lys, and Xaa at positions 26 and 34 is Arg, each of Xaa at
positions 39-45 is deleted, and each of the other Xaa is the amino
acid in native GLP-1(8-38).
[0216] In another preferred embodiment, Xaa at position 7 is a
modified amino acid or is deleted, Xaa at position 8 is Thr, Ser,
Gly, or Val, Xaa at position 18, 23 or 27 is Lys, and Xaa at
position 26 and 34 is Arg, each of Xaa at positions 37-45 is
deleted, and each of the other Xaa is the amino acid in native
GLP-1(8-36).
[0217] In another preferred embodiment, Xaa at position 7 is a
modified amino acid or is deleted, Xaa at position 8 is Thr, Ser,
Gly, or Val, Xaa at position 18, 23 or 27 is Lys, and Xaa at
position 26 and 34 is Arg, each of Xaa at positions 38-45 is
deleted, and each of the other Xaa is the amino acid in native
GLP-1(8-37).
[0218] In another preferred embodiment, Xaa at position 7 is a
modified amino acid or is deleted, Xaa at position 8 is Thr, Ser,
Gly, or Val, Xaa at position 18, 23 or 27 is Lys, and Xaa at
position 26 and 34 is Arg, each of Xaa at positions 39-45 is
deleted, and each of the other Xaa is the amino acid in native
GLP-1(8-38).
Derivatives
[0219] The term "derivative" is defined as a modification of one or
more amino acid residues of a peptide by chemical means, either
with or without an enzyme, e.g., by alkylation, acylation, ester
formation, or amide formation.
[0220] Lipophilic Substituents
[0221] To obtain a satisfactory protracted profile of action of the
GLP-1 derivative, one or more lipophilic substituents are attached
to a GLP-1 moiety. The lipophilic substituents preferably comprises
4-40 carbon atoms, in particular 8-25 carbon atoms. The lipophilic
substituent may be attached to an amino group of the GLP-1 moiety
by means of a carboxyl group of the lipophilic substituent which
forms an amide bond with an amino group of the amino acid residue
to which it is attached. Preferably, the GLP-1 derivatives have
three, more preferably two, and most preferably one lipophilic
substituent.
[0222] In a preferred embodiment, the present invention relates to
a GLP-1 derivative wherein at least one amino acid residue of the
parent peptide has a lipophilic substituent attached with the
proviso that if only one lipophilic substituent is present and this
substituent is attached to the N-terminal or to the C-terminal
amino acid residue of the parent peptide then this substituent is
an alkyl group or a group which has an ?-carboxylic acid group.
[0223] In another preferred embodiment, the present invention
relates to a GLP-1 derivative having only one lipophilic
substituent which substituent is an alkyl group or a group which
has an ?-carboxylic acid group and is attached to the N-terminal
amino acid residue of the parent peptide.
[0224] In another preferred embodiment, the present invention
relates to a GLP-1 derivative having only one lipophilic
substituent which substituent is an alkyl group or a group which
has an ?-carboxylic acid group and is attached to the C-terminal
amino acid residue of the parent peptide.
[0225] In another preferred embodiment, the present invention
relates to a GLP-1 derivative having only one lipophilic
substituent which substituent can be attached to any one amino acid
residue which is not the N-terminal or C-terminal amino acid
residue of the parent peptide.
[0226] In another preferred embodiment, the present invention
relates to a GLP-1 derivative wherein two lipophilic substituents
are present, one being attached to the N-terminal amino acid
residue while the other is attached to the C-terminal amino acid
residue.
[0227] In another preferred embodiment, the present invention
relates to a GLP-1 derivative wherein two lipophilic substituents
are present, one being attached to the N-terminal amino acid
residue while the other is attached to an amino acid residue which
is not N-terminal or the C-terminal amino acid residue.
[0228] In another preferred embodiment, the present invention
relates to a GLP-1 derivative wherein two lipophilic substituents
are present, one being attached to the C-terminal amino acid
residue while the other is attached to an amino acid residue which
is not the N-terminal or the C-terminal amino acid residue.
[0229] A lipophilic substituent may be attached to an amino acid
residue in such a way that a carboxyl group of the lipophilic
substituent forms an amide bond with an amino group of the amino
acid residue. Alternatively, a lipophilic substituent may be
attached to an amino acid residue in such a way that an amino group
of the lipophilic substituent forms an amide bond with a carboxyl
group of the amino acid residue.
[0230] In a further preferred embodiment, the present invention
relates to a GLP-1 derivative wherein a lipophilic substituent is
attached to the parent peptide by means of a spacer. For example,
the lipophilic substituent may be attached to the GLP-1 moiety by
means of a spacer in such a way that a carboxyl group of the spacer
forms an amide bond with an amino group of the GLP-1 moiety.
[0231] In a most preferred embodiment, the lipophilic substituent
is attached--optionally via a spacer--to the ?-amino group of a Lys
residue contained in the parent peptide.
[0232] In a preferred embodiment, the spacer is an ?,?-amino acid.
Examples of suitable spacers are succinic acid, Lys, Glu or Asp, or
a dipeptide such as Gly-Lys. When the spacer is succinic acid, one
carboxyl group thereof may form an amide bond with an amino group
of the amino acid residue, and the other carboxyl group thereof may
form an amide bond with an amino group of the lipophilic
substituent. When the spacer is Lys, Glu or Asp, the carboxyl group
thereof may form an amide bond with an amino group of the amino
acid residue, and the amino group thereof may form an amide bond
with a carboxyl group of the lipophilic substituent. When Lys is
used as the spacer, a further spacer may in some instances be
inserted between the ?-amino group of Lys and the lipophilic
substituent. In one preferred embodiment, such a further spacer is
succinic acid which forms an amide bond with the ?-amino group of
Lys and with an amino group present in the lipophilic substituent.
In another preferred embodiment such a further spacer is Glu or Asp
which forms an amide bond with the ?-amino group of Lys and another
amide bond with a carboxyl group present in the lipophilic
substituent, that is, the lipophilic substituent is a
N.sup.?-acylated lysine residue. Other preferred spacers are
N.sup.?-(?-L-glutamyl), N.sup.?-(?-L-asparagyl), N.sup.?-glycyl,
and N.sup.?-(?-(?-aminobutanoyl).
[0233] In another preferred embodiment of the present invention,
the lipophilic substituent has a group which can be negatively
charged. One preferred such group is a carboxylic acid group.
[0234] In a further preferred embodiment, the lipophilic
substituent comprises from 4 to 40 carbon atoms, more preferred
from 8 to 25 carbon atoms.
[0235] In a further preferred embodiment, the lipophilic
substituent is attached to the parent peptide by means of a spacer
which is an unbranched alkane ?,?-dicarboxylic acid group having
from 1 to 7 methylene groups, preferably two methylene groups which
spacer forms a bridge between an amino group of the parent peptide
and an amino group of the lipophilic substituent.
[0236] In a further preferred embodiment, the lipophilic
substituent is attached to the parent peptide by means of a spacer
which is an amino acid residue except Cys, or a dipeptide such as
Gly-Lys. The expression "a dipeptide such as Gly-Lys" is defined
herein as a dipeptide wherein the C-terminal amino acid residue is
Lys, His or Trp, preferably Lys, and wherein the N-terminal amino
acid residue is selected from the group comprising Ala, Arg, Asp,
Asn, Gly, Glu, Gln, Ile, Leu, Val, Phe and Pro.
[0237] In a further preferred embodiment, the lipophilic
substituent is attached to the parent peptide by means of a spacer
which is an amino acid residue except Cys, or is a dipeptide such
as Gly-Lys and wherein a carboxyl group of the parent peptide forms
an amide bond with an amino group of a Lys residue or a dipeptide
containing a Lys residue, and the other amino group of the Lys
residue or a dipeptide containing a Lys residue forms an amide bond
with a carboxyl group of the lipophilic substituent.
[0238] In a further preferred embodiment, the lipophilic
substituent is attached to the parent peptide by means of a spacer
which is an amino acid residue except Cys, or is a dipeptide such
as Gly-Lys and wherein an amino group of the parent peptide forms
an amide bond with a carboxylic group of the amino acid residue or
dipeptide spacer, and an amino group of the amino acid residue or
dipeptide spacer forms an amide bond with a carboxyl group of the
lipophilic substituent.
[0239] In a further preferred embodiment, the lipophilic
substituent is attached to the parent peptide by means of a spacer
which is an amino acid residue except Cys, or is a dipeptide such
as Gly-Lys and wherein a carboxyl group of the parent peptide forms
an amide bond with an amino group of the amino acid residue spacer
or dipeptide spacer, and the carboxyl group of the amino acid
residue spacer or dipeptide spacer forms an amide bond with an
amino group of the lipophilic substituent.
[0240] In a further preferred embodiment, the lipophilic
substituent is attached to the parent peptide by means of a spacer
which is an amino acid residue except Cys, or is a dipeptide such
as Gly-Lys, and wherein a carboxyl group of the parent peptide
forms an amide bond with an amino group of a spacer which is Asp or
Glu, or a dipeptide spacer containing an Asp or Glu residue, and a
carboxyl group of the spacer forms an amide bond with an amino
group of the lipophilic substituent.
[0241] In a further preferred embodiment, the lipophilic
substituent is a partially or completely hydrogenated
cyclopentanophenathrene skeleton.
[0242] In a further preferred embodiment, the lipophilic
substituent is a straight-chain or branched alkyl group. In a
further preferred embodiment, the lipophilic substituent is the
acyl group of a straight-chain or branched fatty acid.
[0243] In a further preferred embodiment, the lipophilic
substituent is an acyl group of the formula
CH.sub.3(CH.sub.2).sub.nCO--, wherein n is an integer from 4 to 38,
preferably an integer from 4 to 24, more preferrably
CH.sub.3(CH.sub.2).sub.6CO--, CH.sub.3(CH.sub.2).sub.8CO--,
CH.sub.3(CH.sub.2).sub.10CO--, CH.sub.3(CH.sub.2).sub.12CO--,
CH.sub.3(CH.sub.2).sub.14CO--, CH.sub.3(CH.sub.2).sub.16CO--,
CH.sub.3(CH.sub.2).sub.18CO--, CH.sub.3(CH.sub.2).sub.20CO-- or
CH.sub.3(CH.sub.2).sub.22CO--.
[0244] In a further preferred embodiment, the lipophilic
substituent is an acyl group of a straight-chain or branched alkane
?,?-dicarboxylic acid.
[0245] In a further preferred embodiment, the lipophilic
substituent is an acyl group of the formula
HOOC(CH.sub.2).sub.mCO--, wherein m is an integer from 4 to 38,
preferably an integer from 4 to 24, more preferably
HOOC(CH.sub.2).sub.14CO--, HOOC(CH.sub.2).sub.16CO--,
HOOC(CH.sub.2).sub.18CO--, HOOC(CH.sub.2).sub.20CO-- or
HOOC(CH.sub.2).sub.22CO--.
[0246] In a further preferred embodiment, the lipophilic
substituent is a group of the formula
CH.sub.3(CH.sub.2).sub.p((CH.sub.2).sub.qCOOH)CHNH--CO(CH.sub.2).sub.2CO--
-, wherein p and q are integers and p+q is an integer of from 8 to
33, preferably from 12 to 28.
[0247] In a further preferred embodiment, the lipophilic
substituent is a group of the formula
CH.sub.3(CH.sub.2).sub.rCO--NHCH(COOH)(CH.sub.2).sub.2CO--, wherein
r is an integer of from 10 to 24.
[0248] In a further preferred embodiment, the lipophilic
substituent is a group of the formula
CH.sub.3(CH.sub.2).sub.sCO--NHCH((CH.sub.2).sub.2COOH)CO--, wherein
s is an integer of from 8 to 24.
[0249] In a further preferred embodiment, the lipophilic
substituent is a group of the formula COOH(CH.sub.2).sub.tCO--
wherein t is an integer of from 8 to 24.
[0250] In a further preferred embodiment, the lipophilic
substituent is a group of the formula
--NHCH(COOH)(CH.sub.2).sub.4NH--CO(CH.sub.2).sub.uCH.sub.3, wherein
u is an integer of from 8 to 18.
[0251] In a further preferred embodiment, the lipophilic
substituent is a group of the formula
CH.sub.3(CH.sub.2).sub.vCO--NH--(CH.sub.2).sub.z--CO, wherein n is
an integer of from 8 to 24 and z is an integer of from 1 to 6.
[0252] In a further preferred embodiment, the lipophilic
substituent is a group of the formula
--NHCH(COOH)(CH.sub.2).sub.4NH--COCH((CH.sub.2).sub.2COOH)NH--CO(CH.sub.2-
).sub.wCH.sub.3, wherein w is an integer of from 10 to 16.
[0253] In a further preferred embodiment, the lipophilic
substituent is a group of the formula
--NHCH(COOH)(CH.sub.2).sub.4NH--CO(CH.sub.2).sub.2CH(COOH)NH--CO(CH.sub.2-
).sub.xCH.sub.3, wherein x is an integer of from 10 to 16.
[0254] In a further preferred embodiment, the lipophilic
substituent is a group of the formula
--NHCH(COOH)(CH.sub.2).sub.4NH--CO(CH.sub.2).sub.2CH(COOH)NHCO(CH.sub.2).-
sub.yCH.sub.3, wherein y is zero or an integer of from 1 to 22.
[0255] In a further preferred embodiment, the lipophilic
substituent contains a group that can be negatively charged. Such a
lipophilic substituent can for example be a substituent which has a
carboxyl group.
[0256] Other Derivatives
[0257] The derivatives of GLP-1 analogues of the present invention
may be in the form of one or more of (a) a C-1-6-ester, (b) an
amide, C-1-6-alkylamide, or C-1-6-dialkylamide, and (c) a
pharmaceutical salt. In a preferred embodiment, the derivatives of
GLP-1 analogues are in the form of an acid addition salt or a
carboxylate salt, most preferably in the form of an acid addition
salt.
[0258] Preferred Derivatives of GLP-1 Analogues of the Present
Invention
[0259] In a preferred embodiment, a parent peptide for a derivative
of the invention is
[0260] Arg.sup.26-GLP-1(7-37); Arg.sup.34-GLP-1(7-37);
Lys.sup.36-GLP-1(7-37); Arg.sup.26,34Lys.sup.36-GLP-1(7-37);
Arg.sup.26,34Lys.sup.38GLP-1(7-38); Arg.sup.26,34Lys.sup.39
GLP-1(7-39); Arg.sup.26,34Lys.sup.40-GLP-1(7-40);
Arg.sup.26Lys.sup.36-GLP-1(7-37); Arg.sup.34Lys.sup.36-GLP-1(7-37);
Arg.sup.26Lys.sup.39-GLP-1(7-39); Arg.sup.34Lys.sup.40-GLP-1(7-40);
Arg.sup.26,34Lys.sup.36,39-GLP-1(7-39);
Arg.sup.26,34Lys.sup.36,40-GLP-1(7-40);
Gly.sup.8Arg.sup.26-GLP-1(7-37); Gly.sup.8Arg.sup.34-GLP-1(7-37);
Gly.sup.8Lys.sup.36-GLP-1(7-37);
Gly.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(7-37);
Gly.sup.8Arg.sup.26,34Lys.sup.39-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.40-GLP-1(7-40);
Gly.sup.8Arg.sup.26Lys.sup.36-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.36-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.39-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.40-GLP-1(7-40);
Gly.sup.8Arg.sup.26,34Lys.sup.36,39-GLP-1(7-39); or
Gly.sup.8Arg.sup.26,34Lys.sup.36,40-GLP-1(7-40).
[0261] In a further preferred embodiment, the parent peptide is
[0262] Arg.sup.26,34Lys.sup.38GLP-1(7-38);
Arg.sup.26,34Lys.sup.39GLP-1(7-39);
Arg.sup.26,34Lys.sup.40GLP-1(740);
Arg.sup.26,34Lys.sup.41GLP-1(7-41);
Arg.sup.26,34Lys.sup.42GLP-1(7-42);
Arg.sup.26,34Lys.sup.43GLP-1(7-43); Arg.sup.26,34Lys44GLP-1(7-44);
Arg.sup.26,34Lys.sup.45GLP-1(7-45);
Arg.sup.26,34Lys.sup.38GLP-1(1-38);
Arg.sup.26,34Lys.sup.39GLP-1(1-39);
Arg.sup.26,34Lys.sup.40GLP-1(1-40);
Arg.sup.26,34Lys.sup.41GLP-1(1-41);
Arg.sup.26,34Lys.sup.42GLP-1(1-42);
Arg.sup.26,34Lys.sup.43GLP-1(1-43);
Arg.sup.26,34Lys.sup.44GLP-1(1-44);
Arg.sup.26,34Lys.sup.45GLP-1(1-45);
Arg.sup.26,34Lys.sup.38GLP-1(2-38);
Arg.sup.26,34Lys.sup.39GLP-1(2-39);
Arg.sup.26,34Lys.sup.40GLP-1(2-40);
Arg.sup.26,34Lys.sup.41GLP-1(2-41); Arg.sup.26,34Lys.sup.42
GLP-1(2-42); Arg.sup.26,34Lys.sup.43GLP-1(2-43);
Arg.sup.26,34Lys.sup.44GLP-1(2-44);
Arg.sup.26,34Lys.sup.45GLP-1(2-45);
Arg.sup.26,34Lys.sup.38GLP-1(3-38);
Arg.sup.26,34Lys.sup.39GLP-1(3-39);
Arg.sup.26,34Lys.sup.40GLP-1(3-40);
Arg.sup.26,34Lys.sup.41GLP-1(3-41);
Arg.sup.26,34Lys.sup.42GLP-1(3-42);
Arg.sup.26,34Lys.sup.43GLP-1(3-43);
Arg.sup.26,34Lys.sup.44GLP-1(3-44);
Arg.sup.26,34Lys.sup.45GLP-1(3-45);
Arg.sup.26,34Lys.sup.38GLP-1(4-38);
Arg.sup.26,34Lys.sup.39GLP-1(4-39);
Arg.sup.26,34Lys.sup.40GLP-1(4-40);
Arg.sup.26,34Lys.sup.41GLP-1(4-41);
Arg.sup.26,34Lys.sup.42GLP-1(4-42);
Arg.sup.26,34Lys.sup.43GLP-1(3-43);
Arg.sup.26,34Lys.sup.44GLP-1(4-44);
Arg.sup.26,34Lys.sup.45GLP-1(4-45);
Arg.sup.26,34Lys.sup.38GLP-1(5-38);
Arg.sup.26,34Lys.sup.39GLP-1(5-39);
Arg.sup.26,34Lys.sub.40GLP-1(5-40);
Arg.sup.26,34Lys.sup.41GLP-1(5-41);
Arg.sup.26,34Lys.sup.42GLP-1(5-42);
Arg.sup.26,34Lys.sup.43GLP-1(5-43);
Arg.sup.26,34Lys.sup.44GLP-1(5-44);
Arg.sup.26,34Lys.sup.45GLP-1(5-45); Arg.sup.26,34
Lys.sup.38GLP-1(6-38); Arg.sup.26,34Lys.sup.39GLP-1(6-39);
Arg.sup.26,34Lys.sup.40GLP-1(6-40);
Arg.sup.26,34Lys.sup.41GLP-1(6-41); Arg.sup.26,34Lys.sup.42
GLP-1(6-42); Arg.sup.26,34Lys.sup.43GLP-1(6-43);
Arg.sup.26,34Lys.sup.44GLP-1(6-44); Arg.sup.26,34Lys.sup.45
GLP-1(6-45); Arg.sup.26Lys.sup.38GLP-1(1-38);
Arg.sup.34Lys.sup.38GLP-1(1-38); Arg.sup.26,34
Lys.sup.36,38GLP-1(1-38); Arg.sup.26Lys.sup.38GLP-1(7-38);
Arg.sup.34Lys.sup.38GLP-1(7-38);
Arg.sup.26,34Lys.sup.36,38GLP-1(7-38);
Arg.sup.26,34Lys.sup.38GLP-1(7-38); Arg.sup.26Lys.sup.39GLP-1(1-39)
Arg.sup.34Lys.sup.39GLP-1(1-39);
Arg.sup.26,34Lys.sup.36,39GLP-1(1-39);
Arg.sup.26Lys.sup.39GLP-1(7-39); Arg.sup.34Lys.sup.39GLP-1(7-39) or
Arg.sup.26,34Lys.sup.36,39GLP-1(7-39).
[0263] In a further preferred embodiment, the present invention
relates to a GLP-1 derivative wherein the parent peptide is
Arg.sup.26-GLP-1(7-37), Arg.sup.34-GLP-1(7-37),
Lys.sup.36GLP-1(7-37), Arg.sup.26,34Lys.sup.36-GLP-1(7-37),
Arg.sup.26Lys.sup.36-GLP-1(7-37), Arg.sup.34Lys.sup.36-GLP-1(7-37),
Gly.sup.8Arg.sup.26-GLP-1(7-37), Gly.sup.8Arg.sup.34-GLP-1(7-37),
Gly.sup.8Lys.sup.36-GLP-1(7-37),
Gly.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(7-37),
Gly.sup.8Arg.sup.26Lys.sup.36-GLP-1(7-37) or
Gly.sup.8Arg.sup.34Lys.sup.36-GLP-1(7-37).
[0264] In a further preferred embodiment, the present invention
relates to a GLP-1 derivative wherein the parent peptide is
Arg.sup.26Lys.sup.38-GLP-1(7-38),
Arg.sup.26,34Lys.sup.38-GLP-1(7-38),
Arg.sup.26,34Lys.sup.36,38-GLP-1(7-38),
Gly.sup.8Arg.sup.26Lys.sup.38-GLP-1(7-38) or
Gly.sup.8Arg.sup.26,34Lys.sup.36,38-GLP-1(7-38).
[0265] In a further preferred embodiment, the present invention
relates to a GLP-1 derivative wherein the parent peptide is
Arg.sup.26Lys.sup.39-GLP-1(7-39),
Arg.sup.26,34Lys.sup.36,39-GLP-1(7-39),
Gly.sup.8Arg.sup.26Lys.sup.39-GLP-1(7-39) or
Gly.sup.8Arg.sup.26,34Lys.sup.36,39-GLP-1(7-39).
[0266] In a further preferred embodiment, the present invention
relates to a GLP-1 derivative wherein the parent peptide is
Arg.sup.34Lys.sup.40-GLP-1(7-40),
Arg.sup.26,34Lys.sup.36,40-GLP-1(7-40),
Gly.sup.8Arg.sup.34Lys.sup.40-GLP-1(7-40) or
Gly.sup.8Arg.sup.26,34Lys.sup.36,40-GLP-1(7-40).
[0267] In a further preferred embodiment, the present invention
relates to a GLP-1 derivative wherein the parent peptide is:
[0268] Arg.sup.26-GLP-1(7-36); Arg.sup.34-GLP-1(7-36);
Arg.sup.26,34Lys.sup.36-GLP-1(7-36); Arg.sup.26-GLP-1(7-36)amide;
Arg.sup.34-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.36-GLP-1(7-36)amide; Arg.sup.26-GLP-1(7-37);
Arg.sup.34-GLP-1(7-37); Arg.sup.26,34Lys.sup.36-GLP-1(7-37);
Arg.sup.26-GLP-1(7-38); Arg.sup.34-GLP-1(7-38);
Arg.sup.26,34Lys.sup.38GLP-1(7-38); Arg.sup.26-GLP-1(7-39);
Arg.sup.34-GLP-1(7-39); Arg.sup.26,34Lys.sup.39-GLP-1(7-39);
[0269] Gly.sup.8Arg.sup.26-GLP-1(7-36);
Gly.sup.8Arg.sup.34-GLP-1(7-36);
Gly.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(7-36);
Gly.sup.8Arg.sup.26-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.34-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26-GLP-1(7-37); Gly.sup.8Arg.sup.34-GLP-1(7-37);
Gly.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(7-37);
Gly.sup.8Arg.sup.26-GLP-1(7-38); Gly.sup.8Arg.sup.34-GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.38GLP-1(7-38);
Gly.sup.8Arg.sup.26-GLP-1(7-39); Gly.sup.8Arg.sup.34-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.39-GLP-1(7-39);
[0270] Val.sup.8Arg.sup.26-GLP-1(7-36);
Val.sup.8Arg.sup.34-GLP-1(7-36);
Val.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(7-36);
Val.sup.8Arg.sup.26-GLP-1(7-36)amide;
Val.sup.8Arg.sup.34-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26-GLP-1(7-37); Val.sup.8Arg.sup.34-GLP-1(7-37);
Val.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(7-37);
Val.sup.8Arg.sup.26-GLP-1(7-38); Val.sup.8Arg.sup.34-GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.38GLP-1(7-38);
Val.sup.8Arg.sup.26-GLP-1(7-39); Val.sup.8Arg.sup.34-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.39-GLP-1(7-39);
[0271] Ser.sup.8Arg.sup.26-GLP-1(7-36);
Ser.sup.8Arg.sup.34-GLP-1(7-36);
Ser.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(7-36);
Ser.sup.8Arg.sup.26-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.34-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26-GLP-1(7-37); Ser.sup.8Arg.sup.34-GLP-1(7-37);
Ser.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(7-37);
Ser.sup.8Arg.sup.26-GLP-1(7-38); Ser.sup.8Arg.sup.34-GLP-1(7-38);
Ser.sup.8Arg.sup.26,34Lys.sup.38 GLP-1(7-38);
Ser.sup.8Arg.sup.26-GLP-1(7-39); Ser.sup.8Arg.sup.34-GLP-1(7-39);
Ser.sup.8Arg.sup.26,34Lys.sup.39-GLP-1(7-39);
[0272] Thr.sup.8Arg.sup.26-GLP-1(7-36);
Thr.sup.8Arg.sup.34-GLP-1(7-36);
Thr.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(7-36);
Thr.sup.8Arg.sup.26-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.34-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.26-GLP-1(7-37); Thr.sup.8Arg.sup.34-GLP-1(7-37);
Thr.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(7-37);
Thr.sup.8Arg.sup.26-GLP-1(7-38); Thr.sup.8Arg.sup.34-GLP-1(7-38);
Thr.sup.8Arg.sup.26,34Lys.sup.38GLP-1(7-38);
Thr.sup.8Arg.sup.26-GLP-1(7-39); Thr.sup.8Arg.sup.34-GLP-1(7-39);
Thr.sup.8Arg.sup.26,34Lys.sup.39-GLP-1(7-39);
[0273] Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36);
Val.sup.8Glu.sup.35 Arg.sup.26,34Lys.sup.36-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37GLP-1(7-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34 Lys.sup.39-GLP-1(7-39);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37GLP-1(7-37);
Val.sup.8Glu.sup.37 Arg.sup.26,34Lys.sup.38 GLP-1(7-38);
Val.sup.8Glu.sup.38 Arg.sup.26,34Lys.sup.39-GLP-1(7-39);
[0274] Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37GLP-1(7-37); Val.sup.8
Asp.sup.37 Arg.sup.26,34Lys.sup.38 GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-GLP-1(7-39);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37GLP-1(7-37);
Val.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-GLP-1(7-39);
[0275] Ser.sup.8Glu.sup.35 Arg.sup.26,34Lys.sup.36-GLP-1(7-36);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34 Lys.sup.39-GLP-1(7-39);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-GLP-1(7-39);
[0276] Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36 Arg.sup.26,34Lys.sup.37GLP-1(7-37);
Ser.sup.8Asp.sup.37 Arg.sup.26,34Lys.sup.38GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-GLP-1(7-39);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37GLP-1(7-37);
Ser.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-GLP-1(7-39);
[0277] Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37GLP-1(7-37);
Thr.sup.8Glu.sup.37 Arg.sup.26,34Lys.sup.38GLP-1(7-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-GLP-1(7-39);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37 GLP-1(7-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38GLP-1(7-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-GLP-1(7-39);
[0278] Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-GLP-1(7-39);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-GLP-1(7-39);
[0279] Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38GLP-1(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-GLP-1(7-39);
Gly.sup.8Glu.sup.35Arg.sup.26,34 Lys.sup.36-GLP-1(7-36);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34 Lys.sup.38GLP-1(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-GLP-1(7-39);
[0280] Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37GLP-1(7-38);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38GLP-1(7-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-GLP-1(7-39);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37GLP-1(7-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38GLP-1(7-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-GLP-1(7-39);
[0281] Arg.sup.26,34Lys.sup.18-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-GLP-1(7-36)amide; Arg.sup.26,34
Lys.sup.18GLP-1(7-37); Arg.sup.26,34Lys.sup.18GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18GLP-1(7-38);
[0282] Arg.sup.26,34Lys.sup.23-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-GLP-1(7-36)amide; Arg.sup.26,34Lys.sup.23
GLP-1(7-37); Arg.sup.26,34Lys.sup.23GLP-1(7-38);
Gly.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23-GLP-1(7-36);
Gly.sup.8Asp.sup.22Arg.sup.26,34Lys.sup.23-GLP-1(7-36);
Gly.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.22Arg.sup.26,34 Lys.sup.23-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23GLP-1(7-37);
Gly.sup.8Asp.sup.24Arg.sup.26,34 Lys.sup.23GLP-1(7-38);
Gly.sup.8Asp.sup.22Arg.sup.26,34Lys.sup.23GLP-1(7-38);
[0283] Arg.sup.26,34Lys.sup.27-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-GLP-1(7-36)amide; Arg.sup.26,34Lys.sup.27
GLP-1(7-37); Arg.sup.26,34Lys.sup.27GLP-1(7-38);
Gly.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27-GLP-1(7-36);
Gly.sup.8Asp.sup.26Arg.sup.26,34Lys.sup.27-GLP-1(7-36);
Gly.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.26Arg.sup.26,34Lys.sup.27-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27GLP-1(7-37);
Gly.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27GLP-1(7-38);
Gly.sup.8Asp.sup.26Arg.sup.26,34Lys.sup.27GLP-1(7-38);
[0284] Arg.sup.26,34Lys.sup.18-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18GLP-1(7-37);
Arg.sup.26,34Lys.sup.18GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18GLP-1(7-38);
[0285] Arg.sup.26,34Lys.sup.23-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23GLP-1(7-37);
Arg.sup.26,34Lys.sup.23GLP-1(7-38);
Val.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23-GLP-1(7-36);
Val.sup.8Asp.sup.22Arg.sup.26,34Lys.sup.23-GLP-1(7-36);
Val.sub.8Asp.sup.24Arg.sup.26,34Lys.sup.23-GLP-1(7-36)amide;
Val.sup.8Asp.sup.22Arg.sup.26,34Lys.sup.23-GLP-1(7-36)amide;
Val.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23GLP-1(7-37);
Val.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23GLP-1(7-38);
Val.sup.8Asp.sup.22Arg.sup.26,34Lys.sup.23GLP-1(7-38);
[0286] Arg.sup.26,34Lys.sup.27-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27GLP-1(7-37);
Arg.sup.26,34Lys.sup.27GLP-1(7-38);
Val.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27-GLP-1(7-36);
Val.sup.8Asp.sup.26Arg.sup.26,34Lys.sup.27-GLP-1(7-36);
Val.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27-GLP-1(7-36)amide;
Val.sup.8Asp.sup.26Arg.sup.26,34Lys.sup.27-GLP-1(7-36)amide;
Val.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27GLP-1(7-37);
Val.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27GLP-1(7-38);
Val.sup.8Asp.sup.26Arg.sup.26,34Lys.sup.27GLP-1(7-38);
[0287] Arg.sup.26,34Lys.sup.18-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18GLP-1(7-37);
Arg.sup.26,34Lys.sup.18GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18GLP-1(7-38);
[0288] Arg.sup.26,34Lys.sup.23-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23GLP-1(7-37);
Arg.sup.26,34Lys.sup.23GLP-1(7-38);
Ser.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23-GLP-1(7-36);
Ser.sup.8Asp.sup.22Arg.sup.26,34Lys.sup.23-GLP-1(7-36);
Ser.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.22Arg.sup.26,34Lys.sup.23-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23GLP-1(7-37);
Ser.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23GLP-1(7-38);
Ser.sup.8Asp.sup.22Arg.sup.26,34 Lys.sup.23GLP-1(7-38);
[0289] Arg.sup.26,34Lys.sup.27-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27GLP-1(7-37);
Arg.sup.26,34Lys.sup.27GLP-1(7-38);
Ser.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27-GLP-1(7-36);
Ser.sup.8Asp.sup.26Arg.sup.26,34Lys.sup.27-GLP-1(7-36);
Ser.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.26 Arg.sup.26,34Lys.sup.27-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27GLP-1(7-37);
Ser.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27GLP-1(7-38);
Ser.sup.8Asp.sup.26Arg.sup.26,34Lys.sup.27GLP-1(7-38);
[0290] Arg.sup.26,34Lys.sup.18-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18GLP-1(7-37);
Arg.sup.26,34Lys.sup.18GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18GLP-1(7-38);
[0291] Arg.sup.26,34Lys.sup.23GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23GLP-1(7-37);
Arg.sup.26,34Lys.sup.23GLP-1(7-38);
Thr.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23-GLP-1(7-36);
Thr.sup.8Asp.sup.22Arg.sup.26,34Lys.sup.23-GLP-1(7-36);
Thr.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.22Arg.sup.26,34Lys.sup.23-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23GLP-1(7-37);
Thr.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23GLP-1(7-38);
Thr.sup.8Asp.sup.22Arg.sup.26,34Lys.sup.23GLP-1(7-38);
[0292] Arg.sup.26,34Lys.sup.27GLP-1(7-36);
Arg.sup.26,34Lys.sup.37-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27GLP-1(7-37);
Arg.sup.26,34Lys.sup.27GLP-1(7-38);
Thr.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27-GLP-1(7-36);
Thr.sup.8Asp.sup.26Arg.sup.26,34Lys.sup.27-GLP-1(7-36);
Thr.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.26Arg.sup.26,34Lys.sup.27-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27GLP-1(7-37);
Thr.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27GLP-1(7-38); or
Thr.sup.8Asp.sup.26Arg.sup.26,34Lys.sup.27GLP-1(7-38).
[0293] In a further preferred embodiment, the present invention
relates to a GLP-1 derivative wherein the parent peptide is:
Arg.sup.26Lys.sup.36-GLP-1(7-36); Arg.sup.34Lys.sup.36-GLP-1(7-36);
Arg.sup.26Lys.sup.36-GLP-1(7-37); Arg.sup.34Lys.sup.36-GLP-1(7-37);
Arg.sup.26Lys.sup.37-GLP-1(7-37); Arg.sup.34Lys.sup.37-GLP-1(7-37);
Arg.sup.26Lys.sup.39-GLP-1(7-39); Arg.sup.34Lys.sup.39-GLP-1(7-39);
Arg.sup.26,34Lys.sup.36,39-GLP-1(7-39);
Arg.sup.26Lys.sup.18-GLP-1(7-36); Arg.sup.34Lys.sup.18-GLP-1(7-36);
Arg.sup.26Lys.sup.18GLP-1(7-37); Arg.sup.34Lys.sup.18GLP-1(7-37);
Arg.sup.26Lys.sup.18GLP-1(7-38); Arg.sup.34Lys.sup.18GLP-1(7-38);
Arg.sup.26Lys.sup.18GLP-1(7-39);
Arg.sup.34Lys.sup.18GLP-1(7-39);
Arg.sup.26Lys.sup.23-GLP-1(7-36); Arg.sup.34Lys.sup.23-GLP-1(7-36);
Arg.sup.26Lys.sup.23 GLP-1(7-37); Arg.sup.34Lys.sup.23 GLP-1(7-37);
Arg.sup.26Lys.sup.23GLP-1(7-38); Arg.sup.34Lys.sup.23GLP-1(7-38);
Arg.sup.26Lys.sup.23GLP-1(7-39);
Arg.sup.34Lys.sup.23GLP-1(7-39);
Arg.sup.26Lys.sup.27-GLP-1(7-36); Arg.sup.34Lys.sup.27-GLP-1(7-36);
Arg.sup.26Lys.sup.27GLP-1(7-37); Arg.sup.34Lys.sup.27GLP-1(7-37);
Arg.sup.26Lys.sup.27GLP-1(7-38); Arg.sup.34Lys.sup.27GLP-1(7-38);
Arg.sup.26Lys.sup.27GLP-1(7-39);
Arg.sup.34Lys.sup.27GLP-1(7-39);
[0294] Arg.sup.26,34Lys.sup.18,36-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18GLP-1(7-37);
Arg.sup.26,34Lys.sup.18,37GLP-1(7-37);
Arg.sup.26,34Lys.sup.18,38GLP-1(7-38);
Arg.sup.26,34Lys.sup.18,39GLP-1(7-39);
Arg.sup.26,34Lys.sup.23,36-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23GLP-1(7-37); Arg.sup.26,34Lys.sup.23,37
GLP-1(7-37); Arg.sup.26,34Lys.sup.23,38GLP-1(7-38);
Arg.sup.26,34Lys.sup.23,39GLP-1(7-39);
Arg.sup.26,34Lys.sup.27,36-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27GLP-1(7-37);
Arg.sup.26,34Lys.sup.27,37GLP-1(7-37);
Arg.sup.26,34Lys.sup.27,38GLP-1(7-38);
Arg.sup.26,34Lys.sup.27,39GLP-1(7-39); Gly.sup.8GLP-1(7-36);
Gly.sup.8GLP-1(7-37); Gly.sup.8GLP-1(7-38);
Gly.sup.8GLP-1(7-39);
[0295] Gly.sup.8Arg.sup.26Lys.sup.36-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.36-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.36-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.36-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.37-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.37-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.39-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys39-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.36,39-GLP-1(7-39);
Gly.sup.8Arg.sup.26Lys.sup.18-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.18-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.18GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.18GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.18GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.18GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.18GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.18GLP-1(7-39);
Gly.sup.8Arg.sup.26Lys.sup.18-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.23-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.23GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.23GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.23GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.23GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.23GLP-1(7-39); Gly.sup.8Arg.sup.34
Lys.sup.23GLP-1(7-39);
Gly.sup.8Arg.sup.26Lys.sup.27-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.27-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.27GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.27GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.27GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.27GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.27GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.27GLP-1(7-39);
[0296] Gly.sup.8Arg.sup.26,34Lys.sup.18,36-GLP-1(7-36);
Gly.sup.8Arg.sup.26,34Lys.sup.18GLP-1(7-37); Gly.sup.8Arg.sup.26,34
Lys.sup.18,37GLP-1(7-37);
Gly.sup.8Arg.sup.26,34Lys.sup.18,38GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.18,39GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.23,36-GLP-1(7-36);
Gly.sup.8Arg.sup.26,34Lys.sup.23GLP-1(7-37);
Gly.sup.8Arg.sup.26,34Lys23,37GLP-1(7-37);
Gly.sup.8Arg.sup.26,34Lys.sup.23,38GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.23,39GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.27,36-GLP-1(7-36);
Gly.sup.8Arg.sup.26,34Lys.sup.27GLP-1(7-37);
Gly.sup.8Arg.sup.26,34Lys.sup.27,37GLP-1(7-37);
Gly.sup.8Arg.sup.26,34Lys.sup.27,38GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.27,39GLP-1(7-39);
Val.sup.8GLP-1(7-36); Val.sup.8GLP-1(7-37); Val.sup.8GLP-1(7-38);
Val.sup.8GLP-1(7-39);
[0297] Val.sub.8Arg.sup.26Lys.sup.36-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.36-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.36-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.36 GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.37-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.37-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.39-GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.39-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.36,39-GLP-1(7-39);
Val.sup.8Arg.sup.26Lys.sup.18-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.18GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.18(7-37);
Val.sup.8Arg.sup.34Lys.sup.18-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.18GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.18GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.18-GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.18GLP-1(7-39);
Val.sup.8Arg.sup.26Lys.sup.23GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.23GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.23GLP-1 (7-37);
Val.sup.8Arg.sup.34Lys.sup.23GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.23GLP-1(7-38); Val.sup.8Arg.sup.34
Lys.sup.23GLP-1(7-38); Val.sup.8Arg.sup.26Lys.sup.23GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.23GLP-1(7-39);
Val.sup.8Arg.sup.26Lys.sup.27-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.27-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.27GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.27GLP-1(7-37); Val.sup.8Arg.sup.26
Lys.sup.27GLP-1(7-38); Val.sup.8Arg.sup.34Lys.sup.27GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.27GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.27GLP-1(7-39);
[0298] Val.sup.8Arg.sup.26,34Lys.sup.18,36-GLP-1(7-36);
Val.sup.8Arg.sup.26,34Lys.sup.18-GLP-1(7-37);
Val.sup.8Arg.sup.26,34Lys.sup.18,37GLP-1(7-37);
Val.sup.8Arg.sup.26,34Lys.sup.18,38GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.18,39GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.23,36GLP-1(7-36);
Val.sup.8Arg.sup.26,34Lys.sup.23 GLP-1(7-37);
Val.sup.8Arg.sup.26,34Lys.sup.23,37 GLP-1(7-37);
Val.sup.8Arg.sup.26,34Lys.sup.23,38GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.23,39GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.27,36-GLP-1(7-36);
Val.sup.8Arg.sup.26,34Lys.sup.27GLP-1(7-37);
Val.sup.8Arg.sup.26,34Lys.sup.27,37GLP-1(7-37);
Val.sup.8Arg.sup.26,34Lys.sup.27,38GLP-1(7-38); or
Val.sup.8Arg.sup.26,34Lys.sup.27,39GLP-1(7-39).
[0299] In a further preferred embodiment, the parent peptide
is:
[0300] Arg.sup.26-GLP-1(7-37); Arg.sup.34-GLP-1(7-37);
Lys.sup.36-GLP-1(7-37); Arg.sup.26,34Lys.sup.36-GLP-1(7-37);
Arg.sup.26,34Lys.sup.38GLP-1(7-38);
Arg.sup.26,34Lys.sup.39GLP-1(7-39);
Arg.sup.26,34Lys.sup.40-GLP-1(7-40);
Arg.sup.26Lys.sup.36GLP-1(7-37); Arg.sup.34Lys.sup.36-GLP-1(7-37);
Arg.sup.26Lys.sup.39-GLP-1(7-39); Arg.sup.34Lys.sup.40-GLP-1(7-40);
Arg.sup.26,34Lys.sup.36,39-GLP-1(7-39);
Arg.sup.26,34Lys.sup.36,40-GLP-1(7-40);
Gly.sup.8Arg.sup.26-GLP-1(7-37); Gly.sup.8Arg.sup.34-GLP-1(7-37);
Gly.sup.8Lys.sup.36-GLP-1(7-37);
Gly.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(7-37);
Gly.sup.8Arg.sup.26,34Lys.sup.39--GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.40-GLP-1(7-40);
Gly.sup.8Arg.sup.26Lys.sup.36-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.36-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.39-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.40-GLP-1(7-40);
Gly.sup.8Arg.sup.26,34Lys.sup.36,39-GLP-1(7-39); or
Gly.sup.8Arg.sup.26,34Lys36,40 GLP-1(7-40).
[0301] In a further preferred embodiment, the parent peptide
is:
[0302] Arg.sup.26,34Lys.sup.38GLP-1(7-38);
Arg.sup.26,34Lys.sup.39GLP-1(7-39);
Arg.sup.26,34Lys.sup.40GLP-1(7-40);
Arg.sup.26,34Lys.sup.41GLP-1(7-41);
Arg.sup.26,34Lys.sup.42GLP-1(7-42);
Arg.sup.26,34Lys.sup.43GLP-1(7-43);
Arg.sup.26,34Lys.sup.44GLP-1(7-44);
Arg.sup.26,34Lys.sup.45GLP-1(7-45);
Arg.sup.26Lys.sup.38GLP-1(7-38); Arg.sup.34Lys.sup.38GLP-1(7-38);
Arg.sup.26,34Lys.sup.36,38GLP-1(7-38);
Arg.sup.26,34Lys.sup.38GLP-1(7-38);
Arg.sup.26Lys.sup.39GLP-1(7-39); Arg.sup.34Lys.sup.39GLP-1(7-39);
or Arg.sup.26,34Lys.sup.36,39GLP-1(7-39).
[0303] In a further preferred embodiment, the parent peptide is
Arg.sup.26GLP-1(7-37), Arg.sup.34-GLP-1(7-37),
Lys.sup.36GLP-1(7-37) Arg.sup.26,34Lys.sup.36-GLP-1(7-37),
Arg.sup.26Lys.sup.36-GLP-1(7-37), Arg.sup.34Lys.sup.36-GLP-1(7-37)
Gly.sup.8Arg.sup.26-GLP-1(7-37), Gly.sup.8Arg.sup.34-GLP-1(7-37),
Gly.sup.8Lys.sup.36-GLP-1(7-37),
Gly.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(7-37),
Gly.sup.8Arg.sup.26Lys.sup.36-GLP-1(7-37) or
Gly.sup.8Arg.sup.34Lys.sup.36-GLP-1(7-37).
[0304] In a further preferred embodiment, the parent peptide is
Arg.sup.26Lys.sup.39-GLP-1(7-39),
Arg.sup.26,34Lys.sup.38-GLP-1(7-38),
Arg.sup.26,34Lys.sup.36,38-GLP-1(7-38)
Gly.sup.8Arg.sup.26Lys.sup.38 GLP-1(7-38) or
Gly.sup.8Arg.sup.26,34Lys.sup.36,38-GLP-1(7-38).
[0305] In a further preferred embodiment, the parent peptide is
Arg.sup.26Lys.sup.39-GLP-1(7-39),
Arg.sup.26,34Lys.sup.36,39-GLP-1(7-39),
Gly.sup.8Arg.sup.26Lys.sup.39-GLP-1(7-39) or
Gly.sup.8Arg.sup.26,34Lys.sup.36,39-GLP-1(7-39).
[0306] In a further preferred embodiment, the parent peptide is
Arg.sup.34Lys.sup.40-GLP-1(7-40),
Arg.sup.26,34Lys.sup.36,40GLP-1(7-40),
Gly.sup.8Arg.sup.34Lys.sup.40-GLP-1(7-40) or
Gly.sup.8Arg.sup.26,34Lys.sup.36,40-GLP-1(7-40).
[0307] In a further preferred embodiment, the parent peptide
is:
[0308] Arg.sup.26-GLP-1(7-36); Arg.sup.34-GLP-1(7-36);
Arg.sup.26,34Lys.sup.36GLP-1(7-36); Arg.sup.26-GLP-1(7-36)amide;
Arg.sup.34-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.36-GLP-1(7-36)amide; Arg.sup.26-GLP-1(7-37);
Arg.sup.34-GLP-1(7-37); Arg.sup.26,34Lys.sup.36-GLP-1(7-37);
Arg.sup.26-GLP-1(7-38); Arg.sup.34-GLP-1(7-38);
Arg.sup.26,34Lys.sup.38GLP-1(7-38); Arg.sup.26-GLP-1(7-39);
Arg.sup.34-GLP-1(7-39); Arg.sup.26,34Lys.sup.39-GLP-1(7-39);
Gly.sup.8Arg.sup.26-GLP-1(7-36); Gly.sup.8Arg.sup.34-GLP-1(7-36);
Gly.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(7-36);
Gly.sup.8Arg.sup.26-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.34-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26-GLP-1(7-37); Gly.sup.8Arg.sup.34GLP-1(7-37);
Gly.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(7-37);
Gly.sup.8Arg.sup.26-GLP-1(7-38); Gly.sup.8Arg.sup.34-GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.38GLP-1(7-38);
Gly.sup.8Arg.sup.26-GLP-1(7-39);
[0309] Gly.sup.8Arg.sup.34-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.39-GLP-1(7-39);
Val.sup.8Arg.sup.26-GLP-1(7-36); Val.sup.8Arg.sup.34-GLP-1(7-36);
Val.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(7-36);
Val.sup.8Arg.sup.26-GLP-1(7-36)amide;
Val.sup.8Arg.sup.34-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26-GLP-1(7-37); Val.sup.8Arg.sup.34-GLP-1(7-37);
Val.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(7-37);
Val.sup.8Arg.sup.26-GLP-1(7-38); Val.sup.8Arg.sup.34-GLP-1(7-38);
Val.sub.8Arg.sup.26,34Lys.sup.38GLP-1(7-38);
Val.sup.8Arg.sup.26-GLP-1(7-39); Val.sup.8Arg.sup.34-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.39-GLP-1(7-39);
Ser.sup.8Arg.sup.26-GLP-1(7-36); Ser.sup.8Arg.sup.34-GLP-1(7-36);
Ser.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(7-36);
Ser.sup.8Arg.sup.26-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.34-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26-GLP-1(7-37); Ser.sup.8Arg.sup.34-GLP-1(7-37);
Ser.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(7-37);
Ser.sup.8Arg.sup.26-GLP-1(7-38); Ser.sup.8Arg.sup.34-GLP-1(7-38);
Ser.sup.8Arg.sup.26,34Lys.sup.38GLP-1(7-38);
Ser.sup.8Arg.sup.26-GLP-1(7-39);
Ser.sup.8Arg.sup.26,34Lys.sup.39-GLP-1(7-39);
Thr.sup.8Arg.sup.26-GLP-1(7-36); Thr.sup.8 Arg.sup.34-GLP-1(7-36);
Thr.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(7-36);
Thr.sup.8Arg.sup.26-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.34-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.26-GLP-1(7-37); Thr.sup.8Arg.sup.34-GLP-1(7-37);
Thr.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(7-37);
Thr.sup.8Arg.sup.26-GLP-1(7-38); Thr.sup.8Arg.sup.34-GLP-1(7-38);
Thr.sup.8Arg.sup.26,34Lys.sup.38GLP-1(7-38);
Thr.sup.8Arg.sup.26-GLP-1(7-39); Thr.sup.8Arg.sup.34-GLP-1(7-39);
Thr.sup.8Arg.sup.26,34Lys.sup.39-GLP-1(7-39);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34GLP-1(7-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-GLP-1(7-39);
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.36-GLP-1(7-36);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37GLP-1(7-37);
Val.sup.8Glu.sup.37Arg.sup.26,34 Lys.sup.38GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-GLP-1(7-39);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37GLP-1(7-37);
Val.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-GLP-1(7-39);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37GLP-1(7-37);
Val.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-GLP-1(7-39);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-GLP-1(7-39);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-GLP-1(7-39);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37GLP-1(7-37);
Ser.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37GLP-1(7-37);
Ser.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-GLP-1(7-39);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36);
Thr.sup.8Glu.sup.35Arg.sup.26,34 Lys.sup.36-GLP-1(7-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37GLP-1(7-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38GLP-1(7-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-GLP-1(7-39);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-GLP-1(7-39);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.26,34Lys.sup.37GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-GLP-1(7-39);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-GLP-1(7-39);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38GLP-1(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39);
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.36-GLP-1(7-36);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38GLP-1(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-GLP-1(7-39);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37GLP-1(7-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38GLP-1(7-38);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.39-GLP-1(7-39);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(7-36);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37GLP-1(7-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38GLP-1(7-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-GLP-1(7-39);
Arg.sup.23,34Lys.sup.18-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18GLP-1(7-37);
Arg.sup.26,34Lys.sup.18GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18GLP-1(7-7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18 GLP-1(7-38);
Arg.sup.26,34Lys.sup.23-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23GLP-1(7-37);
Arg.sup.26,34Lys.sup.23GLP-1(7-38);
Gly.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23-GLP-1(7-36);
Gly.sup.8Asp.sup.22Arg.sup.26,34Lys.sup.23-GLP-1(7-36);
Gly.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23GLP-1(7-36)amide;
Gly.sup.8Asp.sup.22Arg.sup.26,34Lys.sup.23GLP-1(7-36)amide;
Gly.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23GLP-1(7-37);
Gly.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23GLP-1(7-38);
Gly.sup.8Asp.sup.22Arg.sup.26,34Lys.sup.23GLP-1(7-38)
Arg.sup.26,34Lys.sup.27-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27GLP-1(7-38);
Gly.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27-GLP-1(7-36);
Gly.sup.8Asp.sup.26Arg.sup.26,34Lys.sup.27-GLP-1(7-36);
Gly.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.26Arg.sup.26,34Lys.sup.27-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27GLP-1(7-37);
Gly.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27GLP-1(7-38);
Gly.sup.8Asp.sup.26Arg.sup.26,34Lys.sup.27GLP-1(7-38);
Arg.sup.26,34Lys.sup.18-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18GLP-1(7-37);
Arg.sup.26,34Lys.sup.18GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18GLP-1(7-38);
Arg.sup.26,34Lys.sup.23-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23GLP-1(7-37);
Arg.sup.26,34Lys.sup.23GLP-1(7-38);
Val.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23-GLP-1(7-36);
Val.sup.8Asp.sup.22Arg.sup.26,34Lys.sup.23-GLP-1(7-36);
Val.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23-GLP-1(7-36)amide;
Val.sup.8Asp.sup.22Arg.sup.26,34Lys.sup.23-GLP-1(7-36)amide;
Val.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23GLP-1(7-37);
Val.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23GLP-1(7-38);
Val.sup.8Asp.sup.22Arg.sup.26,34Lys.sup.23GLP-1(7-38);
Arg.sup.26,34Lys.sup.27-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27GLP-1(7-37);
Arg.sup.26,34Lys.sup.27GLP-1(7-38);
Val.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27-GLP-1(7-36);
Val.sup.8Asp.sup.26Arg.sup.26,34Lys.sup.27-GLP-1(7-36);
Val.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27GLP-1(7-36)amide;
Val.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27GLP-1(7-36)amide;
Val.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27GLP-1(7-37);
Val.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27GLP-1(7-38);
Val.sup.8Asp.sup.26Arg.sup.26,34Lys.sup.27GLP-1(7-38);
Arg.sup.26,34Lys.sup.18GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18GLP-1(7-37);
Arg.sup.26,34Lys.sup.18GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34 Lys.sup.18GLP-1(7-38);
Arg.sup.26,34Lys.sup.23-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23GLP-1(7-37);
Arg.sup.26,34Lys.sup.23GLP-1(7-38);
Ser.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23-GLP-1(7-36);
Ser.sup.8Asp.sup.22Arg.sup.26,34Lys.sup.23-GLP-1(7-36);
Ser.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.22Arg.sup.26,34Lys.sup.23-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23GLP-1(7-37);
Ser.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23GLP-1(7-38);
Ser.sup.8Asp.sup.22Arg.sup.26,34Lys.sup.23GLP-1(7-38);
Arg.sup.26,34Lys.sup.27-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27GLP-1(7-37);
Arg.sup.26,34Lys.sup.27GLP-1(7-38);
Ser.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27-GLP-2(7-36);
Ser.sup.8Asp.sup.26Arg.sup.26,34Lys.sup.27-GLP-1(7-36);
Ser.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.26Arg.sup.26,34Lys.sup.27-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27GLP-1(7-37);
Ser.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27GLP-1(7-38);
Ser.sup.8Asp.sup.26Arg.sup.26,34Lys.sup.27GLP-1(7-38);
Arg.sup.26,34Lys.sup.18-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18GLP-1(7-37);
Arg.sup.26,34Lys.sup.18GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18GLP-1(7-38);
Arg.sup.26,34Lys.sup.23-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23GLP-1(7-37);
Arg.sup.26,34Lys.sup.23GLP-1(7-38);
Thr.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23-GLP-1(7-36);
Thr.sup.8Asp.sup.22Arg.sup.26,34Lys.sup.23-GLP-1(7-36);
Thr.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.22Arg.sup.26,34Lys.sup.23GLP-1(7-36)amide;
Thr.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23GLP-1(7-37);
Thr.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23GLP-1(7-38);
Thr.sup.8Asp.sup.22Arg.sup.26,34Lys.sup.23GLP-1(7-38);
Arg.sup.26,34Lys.sup.27-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27GLP-1(7-37);
Arg.sup.26,34Lys.sup.27GLP-1(7-38);
Thr.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27-GLP-1(7-36);
Thr.sup.8Asp.sup.26,34Arg.sup.26,34Lys.sup.27-GLP-1(7-36);
Thr.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.26Arg.sup.26,34Lys.sup.27-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27GLP-1(7-37);
Thr.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27GLP-1(7-38); or
Thr.sup.8Asp.sup.26Arg.sup.26,34Lys.sup.27GLP-1(7-38).
[0310] In a further preferred embodiment, the present invention
relates to a GLP-1 derivative wherein the parent peptide is:
[0311] Arg.sup.26Lys.sup.36-GLP-1(7-36);
Arg.sup.34Lys.sup.36-GLP-1(7-36); Arg.sup.26Lys.sup.36-GLP-1(7-37);
Arg.sup.34Lys.sup.36-GLP-1(7-37); Arg.sup.26Lys.sup.37-GLP-1(7-37);
Arg.sup.34Lys.sup.37-GLP-1(7-37); Arg.sup.26Lys.sup.39-GLP-1(7-39);
Arg.sup.34Lys.sup.39-GLP-1(7-39);
Arg.sup.26,34Lys.sup.36,39-GLP-1(7-39);
Arg.sup.26Lys.sup.18-GLP-1(7-36); Arg.sup.34Lys.sup.18-GLP-1(7-36);
Arg.sup.26Lys.sup.18GLP-1(7-37); Arg.sup.34Lys.sup.18GLP-1(7-37);
Arg.sup.26Lys.sup.18GLP-1(7-38); Arg.sup.34Lys.sup.18GLP-1(7-38);
Arg.sup.26Lys.sup.18GLP-1(7-39); Arg.sup.34Lys.sup.18GLP-1(7-39);
Arg.sup.26Lys.sup.23-GLP-1(7-36); Arg.sup.34Lys.sup.23-GLP-1(7-36);
Arg.sup.26Lys.sup.23GLP-1(7-37); Arg.sup.34Lys.sup.23GLP-1(7-37);
Arg.sup.26Lys.sup.23GLP-1(7-38); Arg.sup.34Lys.sup.23GLP-1(7-38);
Arg.sup.26Lys.sup.23GLP-1(7-39); Arg.sup.34Lys.sup.23GLP-1(7-39);
Arg.sup.26Lys.sup.27-GLP-1(7-36); Arg.sup.34Lys.sup.27-GLP-1(7-36);
Arg.sup.26Lys.sup.27GLP-1(7-37); Arg.sup.34Lys.sup.27GLP-1(7-37);
Arg.sup.34Lys.sup.27GLP-1(7-38); Arg.sup.34Lys.sup.27GLP-1(7-38);
Arg.sup.26Lys.sup.27GLP-1(7-39); Arg.sup.34Lys.sup.27GLP-2(7-39);
Arg.sup.26,34Lys.sup.18,36-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18GLP-1(7-37);
Arg.sup.26,34Lys.sup.18,37GLP-1(7-37);
Arg.sup.26,34Lys.sup.18,38GLP-1(7-38);
Arg.sup.26,34Lys.sup.18,39GLP-1(7-39);
Arg.sup.26,34Lys.sup.23,36-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23GLP-1(7-37);
Arg.sup.26,34Lys.sup.23,37GLP-1(7-37); Arg.sup.26,34
Lys.sup.23,38GLP-1(7-38); Arg.sup.26,34Lys.sup.23,39GLP-1(7-39);
Arg.sup.26,34Lys.sup.27,38GLP-1(7-36);
Arg.sup.26,34Lys.sup.27GLP-1(7-37);
Arg.sup.26,34Lys.sup.27,37GLP-1(7-37);
Arg.sup.26,34Lys.sup.27,38GLP-1(7-38);
Arg.sup.26,34Lys.sup.27,39GLP-1(7-39); Gly.sup.8GLP-1(7-36);
Gly.sup.8GLP-1(7-37); Gly.sup.8GLP-1(7-38); Gly.sup.8GLP-1(7-39);
Gly.sup.8Arg.sup.26Lys.sup.36-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.36-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.36 GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.36 GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.37-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.37 GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.39-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.39-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.36,39-GLP-1(7-39);
Gly.sup.8Arg.sup.26Lys.sup.18-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.18-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.18GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.18GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.18GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.18GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.18GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.18GLP-1(7-39);
Gly.sup.8Arg.sup.26Lys.sup.23-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.23-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.23GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.23GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.23GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.23GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.23GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.23GLP-1(7-39);
Gly.sup.8Arg.sup.26Lys.sup.27-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.27-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.27GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.27GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.27GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.27GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.27GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.27GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.18,36GLP-1(7-36);
Gly.sup.8Arg.sup.26,34Lys.sup.18GLP-1(7-37);
Gly.sup.8Arg.sup.26,34Lys.sup.18,37GLP-1(7-37);
Gly.sup.8Arg.sup.26,34Lys.sup.18,38 GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.18,39GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.23,26-GLP-1(7-36);
Gly.sup.8Arg.sup.26,34Lys.sup.23GLP-1(7-37);
Gly.sup.8Arg.sup.26,34Lys.sup.23,37GLP-1(7-37);
Gly.sup.8Arg.sup.26,34Lys.sup.23,38GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.23,39GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.27,36-GLP-1(7-36);
Gly.sup.8Arg.sup.26,34Lys.sup.27GLP-1(7-37);
Gly.sup.8Arg.sup.26,34Lys.sup.27,37 GLP-1(7-37);
Gly.sup.8Arg.sup.26,34Lys.sup.27,38GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.27,39GLP-1(7-39);
Val.sup.8GLP-1(7-36); Val.sup.8GLP-1(7-37); Val.sup.8GLP-1(7-38);
Val.sup.8GLP-1(7-39); Val.sup.8Arg.sup.26Lys.sup.36-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.36-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.36-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.36-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.37 GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.37-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.39-GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.39-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.36,39-GLP-1(7-39);
Val.sup.8Arg.sup.26Lys.sup.18GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.18-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.18GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.18GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.18GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.18GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.18GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.18GLP-1(7-39);
Val.sup.8Arg.sup.26Lys.sup.23-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.23-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.23GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.23GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.23GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.23GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.23GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.23GLP-1(7-39);
Val.sup.8Arg.sup.26Lys.sup.27-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.27 GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.27GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.27GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.27GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.27GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.27GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.27GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.18,36-GLP-1(7-36);
Val.sup.8Arg.sup.26,34Lys.sup.18GLP-1(7-37);
Val.sup.8Arg.sup.26,34Lys.sup.18,37GLP-1(7-37);
Val.sup.8Arg.sup.26,34Lys.sup.18,38GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.18,39GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.23,36-GLP-1(7-36);
Val.sup.8Arg.sup.26,34Lys.sup.23GLP-1(7-37);
Val.sup.8Arg.sup.26,34Lys.sup.23,37GLP-1(7-37);
Val.sup.8Arg.sup.26,34Lys.sup.23,38 GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.23,39GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.27,36-GLP-1(7-36);
Val.sup.8Arg.sup.26,34Lys.sup.27GLP-1(7-37);
Val.sup.8Arg.sup.26,34Lys.sup.27,37GLP-1(7-37);
Val.sup.8Arg.sup.26,34Lys.sup.27,38GLP-1(7-38); or
Val.sup.8Arg.sup.26,34Lys.sup.27,39GLP-1(7-39).
[0312] In a further preferred embodiment, the present invention
relates to a GLP-1 derivative wherein the parent peptide is:
[0313] Arg.sup.26-GLP-1(8-37); Arg.sup.34-GLP-1(8-37);
Lys.sup.36-GLP-1(8-37); Arg.sup.26,34Lys.sup.36-GLP-1(8-37);
Arg.sup.26,34Lys.sup.38GLP-1(8-38);
Arg.sup.26,34Lys.sup.39-GLP-1(8-39);
Arg.sup.26,34Lys.sup.40-GLP-1(8-40);
Arg.sup.26Lys.sup.36-GLP-1(8-37); Arg.sup.34Lys.sup.36-GLP-1(8-37);
Arg.sup.26Lys.sup.39-GLP-1(8-39); Arg.sup.34Lys.sup.40-GLP-1(8-40);
Arg.sup.26,34Lys.sup.36,39-GLP-1(8-39);
Arg.sup.26,34Lys.sup.36,40-GLP-1(8-40);
Gly.sup.8Arg.sup.26-GLP-1(8-37); Gly.sup.8Arg.sup.34-GLP-1(8-37);
Gly.sup.8Lys.sup.36-GLP-1(8-37);
Gly.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(8-37);
Gly.sup.8Arg.sup.26,34Lys.sup.39-GLP-1(8-39);
Gly.sup.8Arg.sup.26,34Lys.sup.40-GLP-1(8-40);
Gly.sup.8Arg.sup.26Lys.sup.36-GLP-1(8-37);
Gly.sup.8Arg.sup.34Lys.sup.36-GLP-1(8-37);
Gly.sup.8Arg.sup.26Lys.sup.39-GLP-1(8-39);
Gly.sup.8Arg.sup.34Lys.sup.40-GLP-1(8-40);
Gly.sup.8Arg.sup.26,34Lys.sup.36,39-GLP-1(8-39); or
Gly.sup.8Arg.sup.26,34Lys.sup.36,40-GLP-1(8-40).
[0314] In a further preferred embodiment, the parent peptide
is:
[0315] Arg.sup.26,34Lys.sup.38GLP-1(8-38);
Arg.sup.26,34Lys.sup.39GLP-1(8-39);
Arg.sup.26,34Lys.sup.40GLP-1(8-40);
Arg.sup.26,34Lys.sup.41GLP-1(8-41);
Arg.sup.26,34Lys.sup.42GLP-1(8-42);
Arg.sup.26,34Lys.sup.43GLP-1(8-43); Arg.sup.26,34
Lys.sup.44GLP-1(8-44); Arg.sup.26,34Lys.sup.45GLP-1(8-45);
Arg.sup.26Lys.sup.38GLP-1(8-38); Arg.sup.34Lys.sup.38GLP-1(8-38);
Arg.sup.26,34Lys.sup.36,38GLP-1(8-38);
Arg.sup.26,34Lys.sup.38GLP-1(8-38);
Arg.sup.26Lys.sup.39GLP-1(8-39); Arg.sup.34Lys.sup.39GLP-1(8-39);
or Arg.sup.26,34Lys.sup.36,39GLP-1(8-39).
[0316] In a further preferred embodiment, the parent peptide is
Arg.sup.26-GLP-1(8-37), Arg.sup.34-GLP-1(8-37);
Lys.sup.36-GLP-1(8-37) Arg.sup.26,34Lys.sup.36-GLP-1(8-37),
Arg.sup.26Lys.sup.36-GLP-1(8-37) Arg.sup.34Lys.sup.36-GLP-1(8-37),
Gly.sup.8Arg.sup.26-GLP-1(8-37), Gly.sup.3Arg.sup.34-GLP-1(8-37),
Gly.sup.8Lys.sup.36-GLP-1(8-37),
Gly.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(8-37),
Gly.sup.8Arg.sup.26Lys.sup.36-GLP-1(8-37), or
Gly.sup.8Arg.sup.34Lys.sup.36-GLP-1(8-37).
[0317] In a further preferred embodiment, the parent peptide is
Arg.sup.26Lys.sup.38-GLP-1(8-38),
Arg.sup.26,34Lys.sup.38-GLP-1(8-38),
Arg.sup.26,34Lys.sup.36,38-GLP-1(8-38),
Gly.sup.8Arg.sup.26Lys.sup.38-GLP-1(8-38) or
Gly.sup.8Arg.sup.26,34Lys.sup.36,38 GLP-1(8-38).
[0318] In a further preferred embodiment, the parent peptide is
Arg.sup.26 Lys.sup.39-GLP-1(8-39),
Arg.sup.26,34Lys.sup.36,39-GLP-1(8-39),
Gly.sup.8Arg.sup.26Lys.sup.39-GLP-1(8-39) or
Gly.sup.8Arg.sup.26,34Lys.sup.36,39-GLP-1(8-39).
[0319] In a further preferred embodiment, the present invention
relates to a GLP-1 derivative wherein the parent peptide is
Arg.sup.34Lys.sup.40-GLP-1(8-40),
Arg.sup.26,34Lys.sup.36,40-GLP-1(8-40),
Gly.sup.8Arg.sup.34Lys.sup.40-GLP-1(8-40) or
Gly.sup.8Arg.sup.26,34Lys.sup.36,40-GLP-1(8-40).
[0320] In a further preferred embodiment, the present invention
relates to a GLP-1 derivative wherein the parent peptide is:
[0321] Arg.sup.26-GLP-1(8-36); Arg.sup.34-GLP-1(8-36);
Arg.sup.26,34Lys.sup.36-GLP-1(8-36); Arg.sup.26-GLP-1(8-36)amide;
Arg.sup.34-GLP-1(8-39)amide;
Arg.sup.26,34Lys.sup.36-GLP-1(8-36)amide; Arg.sup.26-GLP-1(8-37);
Arg.sup.34-GLP-1(8-37; Arg.sup.26,34Lys.sup.36-GLP-1(8-37);
Arg.sup.26-GLP-1(8-38); Arg.sup.34-GLP-1(8-38);
Arg.sup.26,34Lys.sup.38GLP-1(8-38); Arg.sup.26-GLP-1(8-39);
Arg.sup.34-GLP-1(8-39); Arg.sup.26,34Lys.sup.39-GLP-1(8-39);
Gly.sup.8Arg.sup.26-GLP-1(8-36); Gly.sup.8Arg.sup.34-GLP-1(8-36);
Gly.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(8-36);
Gly.sup.8Arg.sup.26-GLP-1(8-36)amide;
Gly.sup.8Arg.sup.34-GLP-1(8-36)amide;
Gly.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(8-36)amide;
Gly.sup.8Arg.sup.26-GLP-1(8-37); Gly.sup.8Arg.sup.34-GLP-1(8-37);
Gly.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(8-37);
Gly.sup.8Arg.sup.26-GLP-1(8-38); Gly.sup.8Arg.sup.34-GLP-1(8-38);
Gly.sub.8Arg.sup.26,34Lys.sup.38GLP-1(8-38);
Gly.sup.8Arg.sup.26-GLP-1(8-39);
[0322] Gly.sup.8Arg.sup.34-GLP-1(8-39);
Gly.sup.8Arg.sup.26,34Lys.sup.39-GLP-1(8-39);
Val.sup.8Arg.sup.26-GLP-1(8-36); Val.sup.8Arg.sup.34-GLP-1(8-36);
Val.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(8-36);
Val.sup.8Arg.sup.26-GLP-1(8-36)amide;
Val.sup.8Arg.sup.34-GLP-1(8-36)amide;
Val.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(8-36)amide;
Val.sup.8Arg.sup.26-GLP-1(8-37); Val.sup.8Arg.sup.34-GLP-1(8-37);
Val.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(8-37);
Val.sup.8Arg.sup.26-GLP-1(8-38); Val.sup.8Arg.sup.34-GLP-1(8-38);
Val.sup.8Arg.sup.26,34Lys.sup.38GLP-1(8-38);
Val.sup.8Arg.sup.26-GLP-1(8-39); Val.sup.8Arg.sup.34-GLP-1(8-39);
Val.sup.8Arg.sup.26,34Lys.sup.39-GLP-1(8-39);
Ser.sup.8Arg.sup.26-GLP-1(8-36); Ser.sup.8Arg.sup.34-GLP-1(8-36);
Ser.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(8-36);
Ser.sup.8Arg.sup.26-GLP-1(8-36)amide;
Ser.sup.8Arg.sup.34-GLP-1(8-36)amide;
Ser.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(8-36)amide;
Ser.sup.8Arg.sup.26-GLP-1(8-37); Ser.sup.8Arg.sup.34-GLP-1(8-37);
Ser.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(8-37);
Ser.sup.8Arg.sup.26-GLP-1(8-38); Ser.sup.8Arg.sup.34-GLP-1(8-38);
Ser.sup.8Arg.sup.26,34Lys.sup.38GLP-1(8-38);
Ser.sup.8Arg.sup.26-GLP-1(8-39); Ser.sup.8Arg.sup.34-GLP-1(8-39);
Ser.sup.8Arg.sup.26,34Lys.sup.39-GLP-1(8-39);
Thr.sup.8Arg.sup.26-GLP-1(8-36); Thr.sup.8Arg.sup.34-GLP-1(8-36);
Thr.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(8-36);
Thr.sup.8Arg.sup.26-GLP-1(8-36)amide;
Thr.sup.8Arg.sup.34-GLP-1(8-36)amide;
Thr.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(8-36)amide;
Thr.sup.8Arg.sup.26-GLP-1(8-37); Thr.sup.8Arg.sup.34-GLP-1(8-37);
Thr.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(8-37);
Thr.sup.8Arg.sup.26-GLP-1(8-38); Thr.sup.8Arg.sup.34-GLP-1(8-38);
Thr.sup.8Arg.sup.26,34Lys.sup.38GLP-1(8-38);
Thr.sup.8Arg.sup.26-GLP-1(8-39); Thr.sup.8Arg.sup.34-GLP-1(8-39);
Thr.sup.8Arg.sup.26,34Lys.sup.39-GLP-1(8-39);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(8-36);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(8-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37GLP-1(8-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38GLP-1(8-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-GLP-1(8-39);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(8-36);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(8-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37GLP-1(8-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38GLP-1(8-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-GLP-1(8-39);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(8-36);
Val.sup.8Glu.sup.35 Arg.sup.26,34Lys.sup.36-GLP-1(8-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37GLP-1(8-37);
Val.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38GLP-1(8-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-GLP-1(8-39);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(8-36);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(8-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37GLP-1(8-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38GLP-1(8-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-GLP-1(8-39);
Ser.sup.8Glu.sup.35Arg.sup.26,34 Lys.sup.36-GLP-1(8-36);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(8-36)amide;
Ser.sup.8Glu.sup.36 Arg.sup.26,34Lys.sup.37GLP-1(8-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38GLP-1(8-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-GLP-1(8-39);
Ser.sub.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(8-36);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(8-36)amide;
Ser.sub.8Asp.sup.36Arg.sup.26,34Lys.sup.37GLP-1(8-37);
Ser.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38GLP-1(8-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-GLP-1(8-39);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(8-36);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(8-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37GLP-1(8-37);
Ser.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38GLP-1(8-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34 Lys.sup.39-GLP-1(8-39);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(8-36);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(8-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34 Lys.sup.37GLP-1(8-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38GLP-1(8-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-GLP-1(8-39);
Thr.sup.8Glu.sup.35Arg.sup.26,34 Lys.sup.36-GLP-1(8-36);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(8-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37GLP-1(8-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38GLP-1(8-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-GLP-1(8-39);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(8-36);
Thr.sup.8Asp.sup.35Arg.sup.26,34 Lys.sup.36-GLP-1(8-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37GLP-1(8-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38GLP-1(8-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-GLP-1(8-39);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(8-36);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(8-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34 Lys.sup.37GLP-1(8-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38GLP-(8-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-GLP-1(8-39);
Gly.sup.8Glu.sup.35Arg.sup.26,34 Lys.sup.36-GLP-1(8-36);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(8-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37GLP-1(8-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38GLP-1(8-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-GLP-1(8-39);
Gly.sup.8Glu.sup.35Arg.sup.26,34 Lys.sup.36-GLP-1(8-36);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(8-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37 GLP-1(8-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38GLP-1(8-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-GLP-1(8-39);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(8-36);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(8-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37GLP-1(8-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38GLP-1(8-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-GLP-1(8-39);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(8-36);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-GLP-1(8-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37GLP-1(8-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38GLP-1(8-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-GLP-1(8-39);
Arg.sup.26,34Lys.sup.18-GLP-1(8-36);
Arg.sup.26,34Lys.sup.18-GLP-1(8-36)amide;
Arg.sup.26,34Lys.sup.18GLP-1(8-37);
Arg.sup.26,34Lys.sup.18GLP-1(8-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-GLP-1(8-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-GLP-1(8-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-GLP-1(8-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-GLP-1(8-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18GLP-1(8-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18GLP-1(8-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18GLP-1(8-38);
Arg.sup.26,34Lys.sup.23-GLP-1(8-36);
Arg.sup.26,34Lys.sup.23-GLP-1(8-36)amide;
Arg.sup.23,34Lys.sup.23GLP-1(8-37);
Arg.sup.26,34Lys.sup.23GLP-1(8-38);
Gly.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23-GLP-1(8-36);
Gly.sup.8Asp.sup.22Arg.sup.26,34Lys.sup.23-GLP-1(8-36);
Gly.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23-GLP-1(8-36)amide;
Gly.sup.8Asp.sup.22Arg.sup.26,34Lys.sup.23-GLP-1(8-36)amide;
Gly.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23GLP-1(8-37);
Gly.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23GLP-1(8-38);
Gly.sup.8Asp.sup.22Arg.sup.26,34Lys.sup.23GLP-1(8-38);
Arg.sup.26,34Lys.sup.27-GLP-1(8-36);
Arg.sup.26,34Lys.sub.27-GLP-1(8-36)amide;
Arg.sup.26,34Lys.sup.27GLP-1(8-37);
Arg.sup.26,34Lys.sup.27GLP-1(8-38);
Gly.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27-GLP-1(8-36);
Gly.sup.8Asp.sup.26Arg.sup.26,34Lys.sup.27-GLP-1(8-36);
Gly.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27-GLP-1(8-36)amide;
Gly.sup.8Asp.sup.26Arg.sup.26,34Lys.sup.27-GLP-1(8-36)amide;
Gly.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27GLP-1(8-37);
Gly.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27GLP-1(8-38);
Gly.sup.8Asp.sup.26Arg.sup.26,34Lys.sup.27GLP-1(8-38);
Arg.sup.26,34Lys.sup.18-GLP-1(8-36);
Arg.sup.26,34Lys.sup.18-GLP-1(8-36)amide;
Arg.sup.26,34Lys.sup.18GLP-1(8-37);
Arg.sup.26,34Lys.sup.18GLP-1(8-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-GLP-1(8-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-GLP-1(8-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-GLP-1(8-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-GLP-1(8-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18GLP-1(8-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18GLP-1(8-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18GLP-1(8-38);
Arg.sup.26,34Lys.sup.23-GLP-1(8-36);
Arg.sup.26,34Lys.sup.23-GLP-1(8-36)amide;
Arg.sup.26,34Lys.sup.23GLP-1(8-37);
Arg.sup.26,34Lys.sup.23GLP-1(8-38);
Val.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23-GLP-1(8-36);
Val.sup.8Asp.sup.22Arg.sup.26,34Lys.sup.23-GLP-1(8-36);
Val.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23-GLP-1(8-36)amide;
Val.sup.8Asp.sup.22Arg.sup.26,34Lys.sup.23-GLP-1(8-36)amide;
Val.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23GLP-1(8-37);
Val.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23GLP-1(8-38);
Val.sup.8Asp.sup.22Arg.sup.26,34Lys.sup.23GLP-1(8-38);
Arg.sup.26,34Lys.sup.27-GLP-1(8-36);
Arg.sup.26,34Lys.sup.27-GLP-1(8-36)amide;
Arg.sup.26,34Lys.sup.27GLP-1(8-37);
Arg.sup.26,34Lys.sup.27GLP-1(8-38);
Val.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27-GLP-1(8-36);
Val.sup.8Asp.sup.26Arg.sup.26,34Lys.sup.27-GLP-1(8-36);
Val.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27-GLP-1(8-36)amide;
Val.sup.8Asp.sup.26Arg.sup.26,34Lys.sup.27-GLP-1(8-36)amide;
Val.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27GLP-1(8-37);
Val.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27GLP-1(8-38);
Val.sup.8Asp.sup.26Arg.sup.26,34Lys.sup.27GLP-1(8-38);
Arg.sup.26,34Lys.sup.18-GLP-1(8-36);
Arg.sup.26,34Lys.sup.18-GLP-1(8-36)amide;
Arg.sup.26,34Lys.sup.18GLP-1(8-37);
Arg.sup.26,34Lys.sup.18GLP-1(8-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-GLP-1(8-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-GLP-1(8-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-GLP-1(8-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-GLP-1(8-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18GLP-1(8-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18GLP-1(8-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18GLP-1(8-38);
Arg.sup.26,34Lys.sup.23-GLP-1(8-36);
Arg.sup.26,34Lys.sup.23-GLP-1(8-36)amide;
Arg.sup.26,34Lys.sup.23GLP-1(8-37);
Arg.sup.26,34Lys.sup.23GLP-1(8-38);
Ser.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23-GLP-1(8-36);
Ser.sup.8Asp.sup.24Arg.sup.26,34 Lys.sup.23-GLP-1(8-36);
Ser.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23-GLP-1(8-36)amide;
Ser.sup.8Asp.sup.22Arg.sup.26,34Lys.sup.23-GLP-1(8-36)amide;
Ser.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23 GLP-1(8-37);
Ser.sub.8Asp.sup.24Arg.sup.26,34Lys.sup.23GLP-1(8-38);
Ser.sub.8Asp.sup.22Arg.sup.26,34Lys.sup.23GLP-1(8-38);
Arg.sup.26,34Lys.sup.27-GLP-1(8-36);
Arg.sup.26,34Lys.sup.27-GLP-1(8-36)amide;
Arg.sup.26,34Lys.sup.27GLP-1(8-37);
Arg.sup.26,34Lys.sup.27GLP-1(8-38);
Ser.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27-GLP-1(8-36);
Ser.sup.8Asp.sup.26Arg.sup.26,34Lys.sup.27-GLP-1(8-36);
Ser.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27-GLP-1(8-36)amide;
Ser.sup.8Asp.sup.26Arg.sup.26,34Lys.sup.27-GLP-1(8-36)amide;
Ser.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27GLP-1(8-37);
Ser.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27GLP-1(8-38);
Ser.sup.8Asp.sup.26Arg.sup.26,34Lys.sup.27GLP-1(8-38);
Arg.sup.26,34Lys.sup.18-GLP-1(8-36);
Arg.sup.26,34Lys.sup.18-GLP-1(8-36)amide;
Arg.sup.26,34Lys.sup.18GLP-1(8-37);
Arg.sup.26,34Lys.sup.18GLP-1(8-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-GLP-1(8-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-GLP-1(8-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-GLP-1(8-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.8-GLP-1(8-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18GLP-1(8-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18GLP-1(8-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18GLP-1(8-38);
Arg.sup.26,34Lys.sup.23-GLP-1(8-36);
Arg.sup.26,34Lys.sup.23-GLP-1(8-36)amide;
Arg.sup.26,34Lys.sup.23GLP-1(8-37);
Arg.sup.26,34Lys.sup.23GLP-1(8-38);
Thr.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23-GLP-1(8-36);
Thr.sup.8Asp.sup.22Arg.sup.26,34Lys.sup.23-GLP-1(8-36);
Thr.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23-GLP-1(8-36)amide;
Thr.sup.8Asp.sup.22Arg.sup.26,34Lys.sup.23-GLP-1(8-36)amide;
Thr.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23GLP-1(8-37);
Thr.sup.8Asp.sup.24Arg.sup.26,34Lys.sup.23GLP-1(8-38);
Thr.sup.8Asp.sup.22Arg.sup.26,34Lys.sup.23GLP-1(8-38);
Arg.sup.26,34Lys.sup.27-GLP-1(8-36);
Arg.sup.26,34Lys.sup.27-GLP-1(8-36)amide;
Arg.sup.26,34Lys.sup.27GLP-1(8-37);
Arg.sup.26,34Lys.sup.27GLP-1(8-38);
Thr.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27-GLP-1(8-36);
Thr.sup.8Asp.sup.26Arg.sup.26,34Lys.sup.27-GLP-1(8-36);
Thr.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27-GLP-1(8-36)amide;
Thr.sup.8Asp.sup.26Arg.sup.26,34Lys.sup.27-GLP-1(8-36)amide;
Thr.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27GLP-1(8-37);
Thr.sup.8Asp.sup.28Arg.sup.26,34Lys.sup.27GLP-1(8-38); or
Thr.sup.8Asp.sup.26Arg.sup.26,34Lys.sup.27GLP-1(8-38).
[0323] In a further preferred embodiment, the present invention
relates to a GLP-1 derivative wherein the parent peptide is:
[0324] Arg.sup.26Lys.sup.36-GLP-1(8-36);
Arg.sup.34Lys.sup.36-GLP-1(8-36); Arg.sup.26Lys.sup.36-GLP-1(8-37);
Arg.sup.34Lys.sup.36-GLP-1(8-37); Arg.sup.26Lys.sup.37-GLP-1(8-37);
Arg.sup.34Lys.sup.37-GLP-1(8-37); Arg.sup.26Lys.sup.39-GLP-1(8-39);
Arg.sup.34Lys.sup.39-GLP-1(8-39);
Arg.sup.26,34Lys.sup.36,39-GLP-1(8-39);
Arg.sup.26Lys.sup.18-GLP-1(8-36); Arg.sup.34Lys.sup.18GLP-1(8-36);
Arg.sup.26Lys.sup.18GLP-1(8-37); Arg.sup.34Lys.sup.18GLP-1(8-37);
Arg.sup.26Lys.sup.18GLP-1(8-38); Arg.sup.34Lys.sup.18GLP-1(8-38);
Arg.sup.26Lys.sup.18GLP-1(8-39); Arg.sup.34Lys.sup.18GLP-1(8-39);
Arg.sup.26Lys.sup.23-GLP-1(8-36); Arg.sup.34Lys.sup.23-GLP-1(8-36);
Arg.sup.26Lys.sup.23GLP-1(8-37); Arg.sup.34Lys.sup.23GLP-1(8-37);
Arg.sup.26Lys.sup.23GLP-1(8-38); Arg.sup.34Lys.sup.23GLP-1(8-38);
Arg.sup.26Lys.sup.23GLP-1(8-39); Arg.sup.34Lys.sup.23GLP-1(8-39);
Arg.sup.26Lys.sup.27-GLP-1(8-38); Arg.sup.34Lys.sup.27GLP-1(8-36);
Arg.sup.26Lys.sup.27GLP-1(8-37); Arg.sup.34Lys.sup.27GLP-1(8-37);
Arg.sup.26Lys.sup.27-GLP-1(8-38); Arg.sup.34Lys.sup.27GLP-1(8-38);
Arg.sup.26Lys.sup.27GLP-1(8-39); Arg.sup.34Lys.sup.27GLP-1(8-39);
Arg.sup.26,34Lys.sup.18,36-GLP-1(8-36);
Arg.sup.26,34Lys.sup.18GLP-1(8-37);
Arg.sup.26,34Lys.sup.18,37GLP-1(8-37);
Arg.sup.26,34Lys.sup.18,38GLP-1(8-38);
Arg.sup.26,34Lys.sup.18,39GLP-1(8-39);
Arg.sup.26,34Lys.sup.23,36-GLP-1(8-36);
Arg.sup.26,34Lys.sup.23GLP-1(8-37); Arg.sup.26,34
Lys.sup.23,37GLP-1(837); Arg.sup.26,34Lys.sup.23,38GLP-1(8-38);
Arg.sup.26,34Lys.sup.23,39GLP-1(8-39);
Arg.sup.26,34Lys.sup.27,36-GLP 1(8-36);
Arg.sup.26,34Lys.sup.27GLP-1(8-37);
Arg.sup.26,34Lys.sup.27,37GLP-1(8-37);
Arg.sup.26,34Lys.sup.27,38GLP-1(8-38);
Arg.sup.26,34Lys.sup.27,39GLP-1(8-39); Gly.sup.8GLP-1(8-36);
Gly.sup.8GLP-1(8-37); Gly.sup.8GLP-1(8-38); Gly.sup.8GLP-1(8-39);
Gly.sup.8Arg.sup.26Lys.sup.36-GLP-1(8-36);
Gly.sup.8Arg.sup.34Lys.sup.36-GLP-1(8-36);
Gly.sup.8Arg.sup.26Lys.sup.36 GLP-1(8-37);
Gly.sup.8Arg.sup.34Lys.sup.36-GLP-1(8-37);
Gly.sup.8Arg.sup.26Lys.sup.37-GLP-1(8-37);
Gly.sup.8Arg.sup.34Lys.sup.37-GLP-1(8-37);
Gly.sup.8Arg.sup.26Lys.sup.39-GLP-1(8-39);
Gly.sup.8Arg.sup.34Lys.sup.39-GLP-1(8-39);
Gly.sup.8Arg.sup.26,34Lys.sup.36,39-GLP-1(8-39);
Gly.sup.8Arg.sup.26Lys.sup.18-GLP-1(8-36);
Gly.sup.8Arg.sup.34Lys.sup.18-GLP-1(8-36);
Gly.sup.8Arg.sup.26Lys.sup.18GLP-1(8-37);
Gly.sup.8Arg.sup.34Lys.sup.18GLP-1(8-37);
Gly.sup.8Arg.sup.26Lys.sup.18GLP-1(8-38);
Gly.sup.8Arg.sup.34Lys.sup.18GLP-1(8-38);
Gly.sup.8Arg.sup.26Lys.sup.18GLP-1(8-39);
Gly.sup.8Arg.sup.34Lys.sup.18GLP-1(8-39);
Gly.sup.8Arg.sup.26Lys.sup.23-GLP-1(8-36);
Gly.sup.8Arg.sup.34Lys.sup.23-GLP-1(8-36);
Gly.sup.8Arg.sup.26Lys.sup.23GLP-1(8-37);
Gly.sup.8Arg.sup.34Lys.sup.23GLP-1(8-37);
Gly.sup.8Arg.sup.26Lys.sup.23GLP-1(8-38);
Gly.sup.8Arg.sup.34Lys.sup.23GLP-1(8-38);
Gly.sup.8Arg.sup.26Lys.sup.23GLP-1(8-39);
Gly.sup.8Arg.sup.34Lys.sup.23GLP-1(8-39);
Gly.sup.8Arg.sup.26Lys.sup.27-GLP-1(8-36);
Gly.sup.8Arg.sup.34Lys.sup.27-GLP-1(8-36);
Gly.sup.8Arg.sup.26Lys.sup.27GLP-1(8-37);
Gly.sup.8Arg.sup.34Lys.sup.27GLP-1(8-37);
Gly.sup.8Arg.sup.26Lys.sup.27GLP-1(8-38);
Gly.sup.8Arg.sup.34Lys.sup.27GLP-1(8-38);
Gly.sup.8Arg.sup.26Lys.sup.27GLP-1(8-39);
Gly.sup.8Arg.sup.34Lys.sup.27GLP-1(8-39);
Gly.sup.8Arg.sup.26,34Lys.sup.18,36-GLP-1(8-36);
Gly.sup.8Arg.sup.26,34Lys.sup.18GLP-1(8-37);
Gly.sup.8Arg.sup.26,34Lys.sup.18,37GLP-1(8-37);
Gly.sup.8Arg.sup.26,34Lys.sup.18,38GLP-1(8-38);
Gly.sup.8Arg.sup.26,34Lys.sup.18,39GLP-1(8-39);
Gly.sup.8Arg.sup.23,36Lys.sup.23,36-GLP-1(8-36);
Gly.sup.8Arg.sup.26,34Lys.sup.23GLP-1(8-37);
Gly.sup.8Arg.sup.26,34Lys.sup.23,37GLP-1(8-37);
Gly.sup.8Arg.sup.26,34Lys.sup.23,38GLP-1(8-38);
Gly.sup.8Arg.sup.26,34Lys.sup.23,39GLP-1(8-39);
Gly.sup.8Arg.sup.26,34Lys.sup.27,36-GLP-1(8-36);
Gly.sup.8Arg.sup.26,34Lys.sup.27GLP-1(8-37);
Gly.sup.8Arg.sup.26,34Lys.sup.27,37GLP-1(8-37);
Gly.sup.8Arg.sup.26,34Lys.sup.27,38GLP-1(8-38);
Gly.sup.8Arg.sup.26,34Lys.sup.27,39GLP-1(8-39);
Val.sup.8GLP-1(8-36); Val.sup.8GLP-1(8-37); Val.sup.8GLP-1(8-38);
Val.sup.8GLP-1(8-39); Val.sup.8Arg.sup.26Lys.sup.36GLP-1(8-36);
Val.sup.8Arg.sup.34Lys.sup.36GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.36-GLP-1(8-37);
Val.sup.8Arg.sup.34Lys.sup.36-GLP-1(8-37);
Val.sup.8Arg.sup.26Lys.sup.37-GLP-1(8-37);
Val.sup.8Arg.sup.34Lys.sup.37-GLP-1(8-37);
Val.sup.8Arg.sup.26Lys.sup.39-GLP-1(8-39);
Val.sup.8Arg.sup.34Lys.sup.39-GLP-1(8-39);
Val.sup.8Arg.sup.26,34Lys.sup.36,39-GLP-1(8-39);
Val.sup.8Arg.sup.26Lys.sup.18-GLP-1(8-36);
Val.sup.8Arg.sup.34Lys.sup.18-GLP-1(8-36);
Val.sup.8Arg.sup.26Lys.sup.18GLP-1(8-37);
Val.sup.8Arg.sup.34Lys.sup.18GLP-1(8-37);
Val.sup.8Arg.sup.26Lys.sup.18GLP-1(8-38);
Val.sup.8Arg.sup.34Lys.sup.18GLP-1(8-38);
Val.sup.8Arg.sup.26Lys.sup.18GLP-1(8-39);
Val.sup.8Arg.sup.34Lys.sup.18GLP-1(8-39);
Val.sup.8Arg.sup.26Lys.sup.23-GLP-1(8-36);
Val.sup.8Arg.sup.34Lys.sup.23-GLP-1(8-36);
Val.sup.8Arg.sup.26Lys.sup.23GLP-1(8-37);
Val.sup.8Arg.sup.34Lys.sup.23GLP-1(8-37);
Val.sup.8Arg.sup.26Lys.sup.23GLP-1(8-38);
Val.sup.8Arg.sup.34Lys.sup.23GLP-1(8-38);
Val.sup.8Arg.sup.26Lys.sup.23GLP-1(8-39);
Val.sup.8Arg.sup.34Lys.sup.23GLP-1(8-39);
Val.sup.8Arg.sup.26Lys.sup.27 GLP-1(8-36);
Val.sup.8Arg.sup.34Lys.sup.27-GLP-1(8-36);
Val.sup.8Arg.sup.26Lys.sup.27GLP-1(8-37);
Val.sup.8Arg.sup.34Lys.sup.27GLP-1(8-37);
Val.sup.8Arg.sup.26Lys.sup.27GLP-1(8-38);
Val.sup.8Arg.sup.34Lys.sup.27GLP-1(8-38);
Val.sup.8Arg.sup.26Lys.sup.27GLP-1(8-39);
Val.sup.8Arg.sup.34Lys.sup.27GLP-1(8-39);
Val.sup.8Arg.sup.26,34Lys.sup.18,36-GLP-1(8-36);
Val.sup.8Arg.sup.26,34Lys.sup.18GLP-1(8-37);
Val.sup.8Arg.sup.26,34Lys.sup.18,37GLP-1(8-37);
Val.sup.8Arg.sup.26,34Lys.sup.18,38GLP-1(8-38);
Val.sup.8Arg.sup.26,34Lys.sup.18,39GLP-1(8-39);
Val.sup.8Arg.sup.26,34Lys.sup.23,36-GLP-1(8-36);
Val.sup.8Arg.sup.26,34Lys.sup.23GLP-1(8-37);
Val.sup.8Arg.sup.26,34Lys.sup.23,37GLP-1(8-37);
Val.sup.8Arg.sup.26,34Lys.sup.23,38GLP-1(8-38);
Val.sup.8Arg.sup.26,34Lys.sup.23,39GLP-1(8-39);
Val.sup.8Arg.sup.26,34Lys.sup.27,36-GLP-1(8-36);
Val.sup.8Arg.sup.26,34Lys.sup.27GLP-1(8-37);
Val.sup.8Arg.sup.26,34Lys.sup.27,37GLP-1(8-37);
Val.sup.8Arg.sup.26,34Lys.sup.27,38GLP-1(8-38); or
Val.sup.8Arg.sup.26,34Lys.sup.27,39GLP-1(8-39).
[0325] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26 (N.sup.?-tetradecanoyl)-GLP-1(7-37).
[0326] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.34(N.sup.?-tetradecanoyl)-GLP-1(7-37).
[0327] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26,34-bis(N.sup.?-tetradecanoyl)-GLP-1(7-37).
[0328] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-tetradecanoyl)-GLP-1(7-37).
[0329] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.34(N.sup.?-tetradecanoyl)-GLP-1(7-37).
[0330] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26,34-bis(N.sup.?-tetradecanoyl)-GLP-1(7-37).
[0331] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26Lys.sup.34(N.sup.?-tetradecanoyl)-GLP-1(7-37).
[0332] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-tetradecanoyl)-GLP-1(7-38).
[0333] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.34(N.sup.?-tetradecanoyl)-GLP-1(7-38).
[0334] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26,34-bis(N.sup.?-tetradecanoyl)-GLP-1(7-38).
[0335] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-tetradecanoyl)-GLP-1(7-38).
[0336] In a further preferred embodiment, the GLP-1 derivative is
Gly.sub.8Lys.sup.34(N.sup.?-tetradecanoyl)-GLP-1(7-38).
[0337] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26,34-bis(N.sup.?-tetradecanoyl)-GLP-1(7-38).
[0338] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26Lys.sup.34(N.sup.?-tetradecanoyl)-GLP-1(7-38).
[0339] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-tetradecanoyl)-GLP-1(7-39).
[0340] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.34(N.sup.?-tetradecanoyl)-GLP-1(7-39).
[0341] In a farther preferred embodiment, the GLP-1 derivative is
Lys.sup.26,34-bis(N.sup.?-tetradecanoyl)-GLP-1(7-39).
[0342] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-tetradecanoyl)-GLP-1(7-39).
[0343] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.34(N.sup.?-tetradecanoyl)-GLP-1(7-39).
[0344] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26,34-bis(N.sup.?-tetradecanoyl)-GLP-1(7-39).
[0345] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26Lys.sup.34(N.sup.?-tetradecanoyl)-GLP-1(7-39).
[0346] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-tetradecanoyl)-GLP-1(7-40).
[0347] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.34(N.sup.?-tetradecanoyl)-GLP-1(7-40).
[0348] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26,34-bis(N.sup.?-tetradecanoyl)-GLP-1(7-40).
[0349] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-tetradecanoyl)-GLP-1(7-40).
[0350] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.34(N.sup.?-tetradecanoyl)-GLP-1(7-40).
[0351] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26,34-bis(N.sup.?-tetradecanoyl)-GLP-1(7-40).
[0352] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26Lys.sup.34(N.sup.?-tetradecanoyl)-GLP-1(7-40).
[0353] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-tetradecanoyl)-GLP-1(7-36).
[0354] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.34(N.sup.?-tetradecanoyl)-GLP-1(7-36).
[0355] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26,34-bis(N.sup.?-tetradecanoyl)-GLP-1(7-36).
[0356] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-tetradecanoyl)-GLP-1 (7-36).
[0357] In a farther preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.34(N.sup.?-tetradecanoyl)-GLP-1(7-36).
[0358] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26,34-bis(N.sup.?-tetradecanoyl)-GLP-1(7-36).
[0359] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26Lys.sup.34(N.sup.?-tetradecanoyl)-GLP-1(7-36).
[0360] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-tetradecanoyl)-GLP-1(7-35).
[0361] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.34(N.sup.?-tetradecanoyl)-GLP-1(7-35).
[0362] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26,34-bis(N.sup.?-tetradecanoyl)-GLP-1(7-35).
[0363] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-tetradecanoyl)-GLP-1(7-35).
[0364] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.34(N.sup.?-tetradecanoyl)-GLP-1(7-35).
[0365] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26,34-bis(N.sup.?-tetradecanoyl)-GLP-1(7-35).
[0366] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26Lys.sup.34(N.sup.?-tetradecanoyl)-GLP-1(7-35).
[0367] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-tetradecanoyl)-GLP-1(7-36)amide.
[0368] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.34(N.sup.?-tetradecanoyl)-GLP-1(7-36)amide.
[0369] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26,34-bis(N.sup.?-tetradecanoyl)-GLP-1(7-36)amide.
[0370] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-tetradecanoyl)-GLP-1(7-36)amide.
[0371] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.34(N.sup.?-tetradecanoyl)-GLP-1(7-36)amide.
[0372] In a farther preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26,34-bis(N.sup.?-tetradecanoyl)-GLP-1(7-36)amide.
[0373] In a farther preferred embodiment, the GLP-1 derivative is
Arg.sup.26Lys.sup.34 (N.sup.?-tetradecanoyl)-GLP-1(7-36)amide.
[0374] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Arg.sup.26Lys.sup.34(N.sup.?-tetradecanoyl)-GLP-1(7-37).
[0375] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-tetradecanoyl)Arg.sup.34-GLP-1(7-37).
[0376] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-tetradecanoyl)Arg.sup.34-GLP-1(7-37).
[0377] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26,34Lys.sup.36(N.sup.?-tetradecanoyl)-GLP-1(7-37).
[0378] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Arg.sup.26Lys.sup.36(N.sup.?-tetradecanoyl)-GLP-1(7-37).
[0379] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Arg.sup.26Lys.sup.34(N.sup.?-tetradecanoyl)-GLP-1(7-38).
[0380] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-tetradecanoyl)Arg.sup.34GLP-1(7-38).
[0381] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-tetradecanoyl)Arg.sup.34-GLP-1(7-38).
[0382] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26,34Lys.sup.36(N.sup.?-tetradecanoyl)-GLP-1(7-38).
[0383] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26,34Lys.sup.38(N.sup.?-tetradecanoyl)-GLP-1(7-38).
[0384] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Arg.sup.26,34Lys.sup.36(N.sup.?-tetradecanoyl)-GLP-1(7-38).
[0385] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Arg.sup.26Lys.sup.34(N.sup.?-tetradecanoyl)-GLP-1(7-39).
[0386] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-tetradecanoyl)Arg.sup.34-GLP-1(7-39).
[0387] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-tetradecanoyl)Arg.sup.34-GLP-1(7-39).
[0388] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26,34Lys.sup.36(N.sup.?-tetradecanoyl)-GLP-1(7-39).
[0389] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Arg.sup.26,34Lys.sup.36(N.sup.?-tetradecanoyl)-GLP-1(7-39).
[0390] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Arg.sup.26Lys.sup.34(N.sup.?-tetradecanoyl)-GLP-1(7-40).
[0391] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26 (N.sup.?-tetradecanoyl)Arg.sup.34-GLP-1(7-40).
[0392] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-tetradecanoyl)Arg.sup.34-GLP-1(7-40).
[0393] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26,34Lys.sup.36(N.sup.?-tetradecanoyl)-GLP-1(7-40).
[0394] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Arg.sup.26,34Lys.sup.36(N.sup.?-tetradecanoyl)-GLP-1(7-40).
[0395] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-37).
[0396] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.34(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-37).
[0397] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26,34-bis(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-37).
[0398] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-37).
[0399] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.34(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-37).
[0400] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26,34-bis(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-37).
[0401] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-38).
[0402] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.34(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-38).
[0403] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26,34-bis(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-38).
[0404] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-38).
[0405] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.34(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-38).
[0406] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26,34-bis(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-38).
[0407] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-39).
[0408] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.34(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-39).
[0409] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26,34-bis(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-39).
[0410] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-39).
[0411] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.34(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-39).
[0412] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26,34-bis(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-39).
[0413] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-40).
[0414] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.34(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-40).
[0415] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26,34-bis(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-40).
[0416] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-40).
[0417] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.34(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-40).
[0418] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26,34-bis(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-40).
[0419] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-36).
[0420] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.34(_-(?-carboxynonadecanoyl))-GLP-1(7-36).
[0421] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26,34-bis(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-36).
[0422] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-36).
[0423] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.34(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-36).
[0424] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26,34-bis(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-36).
[0425] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-36)amide.
[0426] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.34(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-36)amide.
[0427] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26,34-bis(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-36)amide.
[0428] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-36)amide.
[0429] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.34(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-36)amide.
[0430] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26,34-bis(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-36)am-
ide.
[0431] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-35).
[0432] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.34(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-35).
[0433] In a farther preferred embodiment, the GLP-1 derivative is
Lys.sup.26,34-bis(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-35).
[0434] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-35).
[0435] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.34(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-35).
[0436] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26,34-bis(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-35).
[0437] In a farther preferred embodiment, the GLP-1 derivative is
Arg.sup.26Lys.sup.34(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-37).
[0438] In a farther preferred embodiment, the GLP-1 derivative is
Gly.sup.8Arg.sup.26Lys.sup.34(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-37-
).
[0439] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-(?-carboxynonadecanoyl))Arg.sup.34-GLP-1(7-37).
[0440] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(?-carboxynonadecanoyl))Arg.sup.34-GLP-1(7-37-
).
[0441] In a farther preferred embodiment, the GLP-1 derivative is
Arg.sup.26,34Lys.sup.36(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-37).
[0442] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Arg.sup.26,34Lys.sup.36(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-
-37).
[0443] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26Lys.sup.34(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-38).
[0444] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Arg.sup.26Lys.sup.34(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-38-
).
[0445] In a farther preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-(?-carboxynonadecanoyl))Arg.sup.34-GLP-1(7-38).
[0446] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(?-carboxynonadecanoyl))Arg.sup.34-GLP-1(7-38-
).
[0447] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26,34Lys.sup.36(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-38).
[0448] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26,34Lys.sup.38(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-38).
[0449] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Arg.sup.26,34Lys.sup.36(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-
-38).
[0450] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26Lys.sup.34(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-39).
[0451] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Arg.sup.26Lys.sup.34(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-39-
).
[0452] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-(?-carboxynonadecanoyl))Arg.sup.34-GLP-1(7-39).
[0453] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(?-carboxynonadecanoyl))Arg.sup.34-GLP-1(7-39-
).
[0454] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26,34Lys.sup.36(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-39).
[0455] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Arg.sup.26,34Lys.sup.36(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-
-39).
[0456] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26Lys.sup.34(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-40).
[0457] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Arg.sup.26Lys.sup.34(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-40-
).
[0458] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26
(N.sup.?-(?-carboxynonadecanoyl))Arg.sup.34-GLP-1(7-40).
[0459] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(?-carboxynonadecanoyl))Arg.sup.34-GLP-1(7-40-
).
[0460] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26,34Lys.sup.36(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-40).
[0461] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Arg.sup.26,34Lys.sup.36(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-
-40).
[0462] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-(7-deoxycholoyl))-GLP-1(7-37).
[0463] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.34(N.sup.?-(7-deoxycholoyl))-GLP-1(7-37).
[0464] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26,34-bis(N.sup.?-(7-deoxycholoyl))-GLP-1(7-37).
[0465] In a farther preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(7-deoxycholoyl))-GLP-1(7-37).
[0466] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.34(N.sup.?-(7-deoxycholoyl))-GLP-1(7-37).
[0467] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26,34-bis(N.sup.?-(7-deoxycholoyl))-GLP-1(7-37).
[0468] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26Lys.sup.34(N.sup.?-(7-deoxycholoyl))-GLP-1(7-37).
[0469] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-(7-deoxycholoyl))-GLP-1(7-38).
[0470] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.34(N.sup.?-(7-deoxycholoyl))-GLP-1(7-38).
[0471] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26,34-bis(N.sup.?-(7-deoxycholoyl))-GLP-1(7-38).
[0472] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(7-deoxycholoyl))-GLP-1(7-38).
[0473] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.34(N.sup.?-(7-deoxycholoyl))-GLP-1(7-38).
[0474] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26,34-bis(N.sup.?-(7-deoxycholoyl))-GLP-1(7-38).
[0475] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26Lys.sup.34(N.sup.?-(7-deoxycholoyl))-GLP-1(7-38).
[0476] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26 (N.sup.?-(7-deoxycholoyl))-GLP-1(7-39).
[0477] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.34(N.sup.?-(7-deoxycholoyl))-GLP-1(7-39).
[0478] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26,34-bis(N.sup.?-(7-deoxycholoyl))-GLP-1(7-39).
[0479] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(7-deoxycholoyl))-GLP-1(7-39).
[0480] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.34(N.sup.?-(7-deoxycholoyl))-GLP-1(7-39).
[0481] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26,34-bis(N.sup.?-(7-deoxycholoyl))-GLP-1(7-39).
[0482] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26Lys.sup.34(N.sup.?-(7-deoxycholoyl))-GLP-1(7-39).
[0483] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-(7-deoxycholoyl))-GLP-1(7-40).
[0484] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.34(N.sup.?-(7-deoxycholoyl))-GLP-1(7-40).
[0485] In a farther preferred embodiment, the GLP-1 derivative is
Lys.sup.26,34-bis(N.sup.?-(7-deoxycholoyl))-GLP-1(7-40).
[0486] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(7-deoxycholoyl))-GLP-1(7-40).
[0487] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.34(N.sup.?-(7-deoxycholoyl))-GLP-1(7-40).
[0488] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26,34-bis(N.sup.?
(7-deoxycholoyl))-GLP-1(7-40).
[0489] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26Lys.sup.34(N.sup.?-(7-deoxycholoyl))-GLP-1(7-40).
[0490] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-(7-deoxycholoyl))-GLP-1(7-36).
[0491] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.34(N.sup.?-(7-deoxycholoyl))-GLP-1(7-36).
[0492] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26,34-bis(N.sup.?-(7-deoxycholoyl))-GLP-1(7-36).
[0493] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(7-deoxycholoyl))-GLP-1(7-36).
[0494] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.34(N.sup.?-(7-deoxycholoyl))-GLP-1(7-36).
[0495] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26,34-bis(N.sup.?-(7-deoxycholoyl))-GLP-1(7-36).
[0496] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26Lys.sup.34(N.sup.?-(7-deoxycholoyl))-GLP-1(7-36).
[0497] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-(7-deoxycholoyl))-GLP-1(7-35).
[0498] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.34(N.sup.?-(7-deoxycholoyl))-GLP-1(7-35).
[0499] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26,34-bis(N.sup.?-(7-deoxycholoyl))-GLP-1(7-35).
[0500] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(7-deoxycholoyl))-GLP-1(7-35).
[0501] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.34(N.sup.?-(7-deoxycholoyl))-GLP-1(7-35).
[0502] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26,34-bis(N.sup.?-(7-deoxycholoyl))-GLP-1(7-35).
[0503] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26Lys.sup.34(N.sup.?-(7-deoxycholoyl))-GLP-1(7-35).
[0504] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-(7-deoxycholoyl))-GLP-1(7-36)amide.
[0505] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.34(N.sup.?-(7-deoxycholoyl))-GLP-1(7-36)amide.
[0506] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26,34-bis(N.sup.?-(7-deoxycholoyl))-GLP-1(7-36)amide.
[0507] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(7-deoxycholoyl))-GLP-1(7-36)amide.
[0508] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.34(N.sup.?-(7-deoxycholoyl))-GLP-1(7-36)amide.
[0509] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26,34-bis(N.sup.?-(7-deoxycholoyl))-GLP-1(7-36)amide.
[0510] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26Lys.sup.34(N.sup.?-(7-deoxycholoyl))-GLP-1(7-36)amide.
[0511] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Arg.sup.26Lys.sup.34(N.sup.?-(7-deoxycholoyl))-GLP-1(7-37).
[0512] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-(7-deoxycholoyl))Arg.sup.34-GLP-1(7-37).
[0513] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(7-deoxycholoyl))Arg.sup.34-GLP-1(7-37).
[0514] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26,34Lys.sup.36(N.sup.?-(7-deoxycholoyl))-GLP-1(7-37).
[0515] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Arg.sup.26,34Lys.sup.36(N.sup.?-(7-deoxycholoyl))-GLP-1(7-37).
[0516] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-(choloyl))-GLP-1(7-37).
[0517] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.34(N.sup.?-(choloyl))-GLP-1(7-37).
[0518] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26,34-bis(N.sup.?-(choloyl))-GLP-1(7-37).
[0519] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(choloyl))-GLP-1(7-37).
[0520] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.34(N.sup.?-(choloyl))-GLP-1(7-37).
[0521] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26,34-bis(N.sup.?-(choloyl))-GLP-1(7-37).
[0522] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26Lys.sup.34(N.sup.?-(choloyl))-GLP-1(7-37).
[0523] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Arg.sup.26Lys.sup.34(N.sup.?-(7-deoxycholoyl))-GLP-1(7-38).
[0524] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-(7-deoxycholoyl))Arg.sup.34-GLP-1(7-38).
[0525] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(7-deoxycholoyl))Arg.sup.34-GLP-1(7-38).
[0526] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26,34Lys.sup.36(N.sup.?-(7-deoxycholoyl))-GLP-1(7-38).
[0527] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26,34Lys.sup.38(N.sup.?-(7-deoxycholoyl))-GLP-1(7-38).
[0528] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Arg.sup.26,34Lys.sup.36(N.sup.?-(7-deoxycholoyl))-GLP-1(7-38).
[0529] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-(choloyl))-GLP-1(7-38).
[0530] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.34 (N.sup.?-(choloyl))-GLP-1(7-38).
[0531] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26,34-bis(N.sup.?-(choloyl))-GLP-1(7-38).
[0532] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(choloyl))-GLP-1(7-38).
[0533] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.34(N.sup.?-(choloyl))-GLP-1(7-38).
[0534] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26,34-bis(N.sup.?-(choloyl))-GLP-1(7-38).
[0535] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26Lys.sup.34(N.sup.?-(choloyl))-GLP-1(7-38).
[0536] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Arg.sup.26Lys.sup.34(N.sup.?-(7-deoxycholoyl))-GLP-1(7-39).
[0537] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-(7-deoxycholoyl))Arg.sup.34-GLP-1(7-39).
[0538] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(7-deoxycholoyl))Arg.sup.34-GLP-1(7-39).
[0539] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26,34Lys.sup.36(N.sup.?-(7-deoxycholoyl))-GLP-1(7-39).
[0540] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Arg.sup.26,34Lys.sup.36(N.sup.?-(7-deoxycholoyl))-GLP-1(7-39).
[0541] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-(choloyl))-GLP-1(7-39).
[0542] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.34(N.sup.?-(choloyl))-GLP-1(7-39).
[0543] In a farther preferred embodiment, the GLP-1 derivative is
Lys.sup.26,34-bis(N.sup.?-(choloyl))-GLP-1(7-39).
[0544] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(choloyl))-GLP-1(7-39).
[0545] In a farther preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.34(N.sup.?-(choloyl))-GLP-1(7-39).
[0546] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26,34-bis(N.sup.?-(choloyl))-GLP-1(7-39).
[0547] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26Lys.sup.34(N.sup.?-(choloyl))-GLP-1(7-39).
[0548] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Arg.sup.26Lys.sup.34(N.sup.?-(7-deoxycholoyl))-GLP-1(7-40).
[0549] In a farther preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-(7-deoxycholoyl))Arg.sup.34-GLP-1(7-40).
[0550] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(7-deoxycholoyl))Arg.sup.34-GLP-1(7-40).
[0551] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26,34Lys.sup.36(N.sup.?-(7-deoxycholoyl))-GLP-1(7-40).
[0552] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Arg.sup.26,34Lys.sup.36(N.sup.?-(7-deoxycholoyl))-GLP-1(7-40).
[0553] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26 (N.sup.?-(choloyl))-GLP-1(7-40).
[0554] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.34(N.sup.?-(choloyl))-GLP-1(7-40).
[0555] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26,34-bis(N.sup.?-(choloyl))-GLP-1(7-40).
[0556] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(choloyl))-GLP-1(7-40).
[0557] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.34(N.sup.?-(choloyl))-GLP-1(7-40).
[0558] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26,34-bis(N.sup.?-(choloyl))-GLP-1(7-40).
[0559] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26Lys.sup.34(N.sup.?-(choloyl))-GLP-1(7-40).
[0560] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-(choloyl))-GLP-1(7-36).
[0561] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.34(N.sup.?-(choloyl))-GLP-1(7-36).
[0562] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26,34-bis(N.sup.?-(choloyl))-GLP-1(7-36).
[0563] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(choloyl))-GLP-1(7-36).
[0564] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.34(N.sup.?-(choloyl))-GLP-1(7-36).
[0565] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26,34-bis(N.sup.?-(choloyl))-GLP-1(7-36).
[0566] In a farther preferred embodiment, the GLP-1 derivative is
Arg.sup.26Lys.sup.34(N.sup.?-(choloyl))-GLP-1(7-36).
[0567] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-(choloyl))-GLP-1(7-35).
[0568] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.34(N.sup.?-(choloyl))-GLP-1(7-35).
[0569] In a further preferred embodiment, the GLP-1 derivative is
Lys.sub.24,36-bis(N.sup.?-(choloyl))-GLP-1(7-35).
[0570] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(choloyl))-GLP-1(7-35).
[0571] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.34(N.sup.?-(choloyl))-GLP-1(7-35).
[0572] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26,34-bis(N.sup.?-(choloyl))-GLP-1(7-35).
[0573] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26Lys.sup.34(N.sup.?-(choloyl))-GLP-1(7-35).
[0574] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-(choloyl))-GLP-1(7-36)amide.
[0575] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.34(N.sup.?-(choloyl))-GLP-1(7-36)amide.
[0576] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26,34-bis(N.sup.?-(choloyl))-GLP-1(7-36)amide.
[0577] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(choloyl))-GLP-1(7-36)amide.
[0578] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.34(N.sup.?-(choloyl))-GLP-1(7-36)amide.
[0579] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26,34-bis(N.sup.?-(choloyl))-GLP-1(7-36)amide.
[0580] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26Lys.sup.34(N.sup.?-(choloyl))-GLP-1(7-36)amide.
[0581] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Arg.sup.26Lys.sup.34(N.sup.?-(choloyl))-GLP-1(7-37).
[0582] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-(choloyl))Arg.sup.34-GLP-1(7-37).
[0583] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(choloyl))Arg.sup.34-GLP-1(7-37).
[0584] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26,34Lys.sup.36(N.sup.?-(choloyl))-GLP-1(7-37).
[0585] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Arg.sup.26,34Lys.sup.36(N.sup.?-(choloyl))-GLP-1(7-37).
[0586] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-(lithocholoyl))-GLP-1(7-37).
[0587] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.34(N.sup.7-(lithocholoyl))-GLP-1(7-37).
[0588] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26,34-bis(N.sup.?-(lithocholoyl))-GLP-1(7-37).
[0589] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(lithocholoyl))-GLP-1(7-37).
[0590] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.34(N.sup.?-(lithocholoyl))-GLP-1(7-37).
[0591] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26,34-bis(N.sup.?-(lithocholoyl))-GLP-1(7-37).
[0592] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26Lys.sup.34(N.sup.?-(lithocholoyl))-GLP-1(7-37).
[0593] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Arg.sup.26Lys.sup.34(N.sup.?-(choloyl))-GLP-1(7-38).
[0594] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-(choloyl))Arg.sup.34-GLP-1(7-38).
[0595] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(choloyl))Arg.sup.34-GLP-1(7-38).
[0596] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26,34Lys.sup.36(N.sup.?-(choloyl))-GLP-1(7-38).
[0597] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26,34Lys.sup.38(N.sup.?-(choloyl))-GLP-1(7-38).
[0598] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Arg.sup.26,34Lys.sup.36(N.sup.?-(choloyl))-GLP-1(7-38).
[0599] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-(lithocholoyl))-GLP-1(7-38).
[0600] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.34(N.sup.?-(lithocholoyl))-GLP-1(7-38).
[0601] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26,34-bis(N.sup.?-(lithocholoyl))-GLP-1(7-38).
[0602] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(lithocholoyl))-GLP-1(7-38).
[0603] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.34(N.sup.?-(lithocholoyl))-GLP-1(7-38).
[0604] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26,34-bis(N.sup.?-(lithocholoyl))-GLP-1(7-38).
[0605] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26Lys.sup.34(N.sup.?-(lithocholoyl))-GLP-1(7-38).
[0606] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Arg.sup.26Lys.sup.34(N.sup.?-(choloyl))-GLP-1(7-39).
[0607] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-(choloyl))Arg.sup.34-GLP-1(7-39).
[0608] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(choloyl))Arg.sup.34-GLP-1(7-39).
[0609] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26,34Lys.sup.36(N.sup.?-(choloyl))-GLP-1(7-39).
[0610] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8
Arg.sup.26,34Lys.sup.36(N.sup.?-(choloyl))-GLP-1(7-39).
[0611] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-(lithocholoyl))-GLP-1(7-39).
[0612] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.34(N.sup.?-(lithocholoyl))-GLP-1(7-39).
[0613] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26,34-bis(N.sup.?-(lithocholoyl))-GLP-1(7-39).
[0614] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(lithocholoyl))-GLP-1(7-39).
[0615] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.34(N.sup.?-(lithocholoyl))-GLP-1(7-39).
[0616] In a farther preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26,34-bis(N.sup.?-(lithocholoyl))-GLP-1(7-39).
[0617] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26Lys.sup.34(N.sup.?-(lithocholoyl))-GLP-1(7-39).
[0618] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Arg.sup.26Lys.sup.34(N.sup.?-(choloyl))-GLP-1(7-40).
[0619] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-(choloyl))Arg.sup.34-GLP-1(7-40).
[0620] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(choloyl))Arg.sup.34-GLP-1(7-40).
[0621] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26,34Lys.sup.36(N.sup.?-(choloyl)) -GLP-1(7-40).
[0622] In a farther preferred embodiment, the GLP-1 derivative is
Gly.sup.8Arg.sup.26,34Lys.sup.36(N.sup.?-(choloyl))-GLP-1(7-40).
[0623] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-(lithocholoyl))-GLP-1(7-40).
[0624] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.34(N.sup.?-(lithocholoyl))-GLP-1(7-40).
[0625] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26,34-bis(N.sup.?-(lithocholoyl))-GLP-1(7-40).
[0626] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(lithocholoyl))-GLP-1(7-40).
[0627] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.34(N.sup.?-(lithocholoyl))-GLP-1(7-40).
[0628] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26,34-bis(N.sup.?-(lithocholoyl))-GLP-1(7-40).
[0629] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26Lys.sup.34(N.sup.?-(lithocholoyl))-GLP-1(7-37).
[0630] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-(lithocholoyl))-GLP-1(7-36).
[0631] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.34(N.sup.?-(lithocholoyl))-GLP-1(7-36).
[0632] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26,34-bis(N.sup.?-(lithocholoyl))-GLP-1(7-36).
[0633] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(lithocholoyl))-GLP-1(7-36).
[0634] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.34(N.sup.?-(lithocholoyl))-GLP-1(7-36).
[0635] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26,34-bis(N.sup.?-(lithocholoyl))-GLP-1(7-36).
[0636] In a farther preferred embodiment, the GLP-1 derivative is
Arg.sup.26Lys.sup.34(N.sup.?-(lithocholoyl))-GLP-1(7-36).
[0637] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-(lithocholoyl))-GLP-1(7-35).
[0638] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.34(N.sup.?-(lithocholoyl))-GLP-1(7-35).
[0639] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26,34-bis(N.sup.?-(lithocholoyl))-GLP-1(7-35).
[0640] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(lithocholoyl))-GLP-1(7-35).
[0641] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.34(N.sup.?-(lithocholoyl))-GLP-1(7-35).
[0642] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26,34-bis(N.sup.?-(lithocholoyl))-GLP-1(7-35).
[0643] In a farther preferred embodiment, the GLP-1 derivative is
Arg.sup.26Lys.sup.34(N.sup.?-(lithocholoyl))-GLP-1(7-35).
[0644] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-(lithocholoyl))-GLP-1(7-36)amide.
[0645] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.34(N.sup.?-(lithocholoyl))-GLP-1(7-36)amide.
[0646] In a farther preferred embodiment, the GLP-1 derivative is
Lys.sup.26,34-bis(N.sup.?-(lithocholoyl))-GLP-1(7-36)amide.
[0647] In a further preferred embodiment, the GLP-1 derivative is
Gly.sub.8Lys.sup.26(N.sup.?-(lithocholoyl))-GLP-1(7-36)amide.
[0648] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.34(N.sup.?-(lithocholoyl))-GLP-1(7-36)amide.
[0649] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26,34-bis(N.sup.?-(lithocholoyl))-GLP-1(7-36)amide.
[0650] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26Lys.sup.34(N.sup.?-(lithocholoyl))-GLP-1(7-36)amide.
[0651] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Arg.sup.26Lys.sup.34(N.sup.?-(lithocholoyl))-GLP-1(7-37).
[0652] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.2 (N.sup.?-(lithocholoyl))Arg.sup.34-GLP-1(7-37).
[0653] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(lithocholoyl))Arg.sup.34-GLP-1(7-37).
[0654] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26,34Lys.sup.36(N.sup.?-(lithocholoyl))-GLP-1(7-37).
[0655] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26,34Lys.sup.38(N.sup.?-(lithocholoyl))-GLP-1(7-37).
[0656] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Arg.sup.26,34Lys.sup.36
(N.sup.?-(lithocholoyl))-GLP-1(7-37).
[0657] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Arg.sup.26Lys.sup.34(N.sup.?-(lithocholoyl))-GLP-1(7-38).
[0658] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-(lithocholoyl))Arg.sup.34-GLP-1(7-38).
[0659] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(lithocholoyl))Arg.sup.34-GLP-1(7-38).
[0660] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26,34Lys.sup.36(N.sup.?-(lithocholoyl))-GLP-1(7-38).
[0661] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26,34Lys.sup.38(N.sup.?-(lithocholoyl))-GLP-1(7-38).
[0662] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Arg.sup.26,34Lys.sup.36(N.sup.?-(lithocholoyl))-GLP-1(7-38).
[0663] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Arg.sup.26Lys.sup.34(N.sup.?-(lithocholoyl))-GLP-1(7-39).
[0664] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26(N.sup.?-(lithocholoyl))Arg.sup.34-GLP-1(7-39).
[0665] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(lithocholoyl))Arg.sup.34-GLP-1(7-39).
[0666] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26,34Lys.sup.36(N.sup.?-(lithocholoyl))-GLP-1(7-39).
[0667] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Arg.sup.26,34Lys.sup.36(N.sup.?-(lithocholoyl))-GLP-1(7-39).
[0668] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Arg.sup.26Lys.sup.34(N.sup.?-(lithocholoyl))-GLP-1(7-40).
[0669] In a further preferred embodiment, the GLP-1 derivative is
Lys.sup.26 (N.sup.?-(lithocholoyl))Arg.sup.34-GLP-1(7-40).
[0670] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Lys.sup.26(N.sup.?-(lithocholoyl))Arg.sup.34-GLP-1(7-40).
[0671] In a further preferred embodiment, the GLP-1 derivative is
Arg.sup.26,34Lys.sup.36(N.sup.?-(lithocholoyl))-GLP-1(7-40).
[0672] In a further preferred embodiment, the GLP-1 derivative is
Gly.sup.8Arg.sup.26,34Lys.sup.36(N.sup.?-(lithocholoyl))-GLP-1(7-40).
[0673] Other preferred embodiments will be described using the
following abbreviations:
Glut=N.sup.?-(?-L-glutamyl)
Aspa=N.sup.?-(?-L-asparagyl)
Glyc=N.sup.?-glycyl
GAB=N.sup.?-(?-(?-aminobutanoyl)
ADod=N.sup.?-dodecanoyl
ATet=N.sup.?-tetradecanoyl
AHex=N.sup.?-hexadecanoyl
AOct=N.sup.?-octadecanoyl
ALit=N.sup.?-lithocholyl
GDod=N.sup.?-dodecanoyl
GTet=N.sup.?-tetradecanoyl
GHex=N.sup.?-hexadecanoyl
GOct=N.sup.?-octadecanoyl
GLit=N.sup.?-lithocholyl
[0674] Other preferred GLP-1 derivatives of the present invention
are:
[0675] Arg.sup.26Lys.sup.34-(Glut-ADod)-GLP-1(7-36);
Arg.sup.34Lys.sup.26-(Glut-ADod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-36);
Arg.sup.26Lys.sup.34-(Glut-ADod)-GLP-1(7-36)amide;
Arg.sup.34Lys.sup.26-(Glut-ADod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-36)amide;
Arg.sup.26Lys.sup.34-(Glut-ADod)-GLP-1(7-37);
Arg.sup.34Lys.sup.26-(Glut-ADod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-37);
Arg.sup.26Lys.sup.34-(Glut-ADod)-GLP-1(7-38);
Arg.sup.34Lys.sup.26-(Glut-ADod)-GLP-1(7-38);
Arg.sup.26,34Lys.sup.38-(Glut-ADod)-GLP-1(7-38);
Arg.sup.26Lys.sup.34-(Glut-ADod)-GLP-1(7-39);
Arg.sup.34Lys.sup.26-(Glut-ADod)-GLP-1(7-39);
Arg.sup.26,34Lys.sup.39-(Glut-ADod)-GLP-1(7-39);
[0676] Gly.sup.8Arg.sup.26Lys.sup.34-(Glut-ADod)-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.26-(Glut-ADod)-GLP-1(7-36);
Gly.sup.8Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.34-(Glut-ADod)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.34Lys.sup.26-(Glut-ADod)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26Lys.sup.34-(Glut-ADod)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26-(Glut-ADod)-GLP-1(7-37);
Gly.sup.8Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34-(Glut-ADod)-GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.26-(Glut-ADod)-GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.38-(Glut-ADod)-GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.34-(Glut-ADod)-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.26-(Glut-ADod)-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.39-(Glut-ADod)-GLP-1(7-39);
[0677] Val.sup.8Arg.sup.26Lys.sup.34-(Glut-ADod)-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.26-(Glut-ADod)-GLP-1(7-36);
Val.sup.8Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.34-(Glut-ADod)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.34Lys.sup.26-(Glut-ADod)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26Lys.sup.34-(Glut-ADod)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26-(Glut-ADod)-GLP-1(7-37);
Val.sup.8Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34(Glut-ADod)-GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.26-(Glut-ADod)-GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.38-(Glut-ADod)-GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.34-(Glut-ADod)-GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.26-(Glut-ADod)-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.39-(Glut-ADod)-GLP-1(7-39);
[0678] Ser.sup.8Arg.sup.26Lys.sup.34-(Glut-ADod)-GLP-1(7-36);
Ser.sup.8Arg.sup.34Lys.sup.26-(Glut-ADod)-GLP-1(7-36);
Ser.sup.8Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-36);
Ser.sup.8Arg.sup.26Lys.sup.34-(Glut-ADod)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.34Lys.sup.26-(Glut-ADod)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26Lys.sup.34-(Glut-ADod)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26-(Glut-ADod)-GLP-1(7-37);
Ser.sup.8Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34-(Glut-ADod)-GLP-1(7-38);
Ser.sup.8Arg.sup.34Lys.sup.26-(Glut-ADod)-GLP-1(7-38);
Ser.sup.8Arg.sup.26,34Lys.sup.38-(Glut-ADod)-GLP-1(7-38);
Ser.sup.8Arg.sup.26Lys.sup.34-(Glut-ADod)-GLP-1(7-39);
Ser.sup.8Arg.sup.34Lys.sup.26-(Glut-ADod)-GLP-1(7-39);
Ser.sup.8Arg.sup.26,34Lys.sup.39-(Glut-ADod)-GLP-1(7-39);
[0679] Thr.sup.8Arg.sup.26Lys.sup.34-(Glut-ADod)-GLP-1(7-36);
Thr.sup.8Arg.sup.34Lys.sup.26-(Glut-ADod)-GLP-1(7-36);
Thr.sup.8Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-36);
Thr.sup.8Arg.sup.26Lys.sup.34-(Glut-ADod)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.34Lys.sup.36-(Glut-ADod)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.26Lys.sup.34-(Glut-ADod)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26-(Glut-ADod)-GLP-1(7-37);
Thr.sup.8Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34-(Glut-ADod)-GLP-1(7-38);
Thr.sup.8Arg.sup.34Lys.sup.26-(Glut-ADod)-GLP-1(7-38);
Thr.sup.8Arg.sup.26,34Lys.sup.38-(Glut-ADod)-GLP-1(7-38);
Thr.sup.8Arg.sup.26Lys.sup.26-(Glut-ADod)-GLP-1(7-39);
Thr.sup.8Arg.sup.34Lys.sup.26-(Glut-ADod)-GLP-1(7-39);
Thr.sup.8Arg.sup.26,34Lys.sup.39-(Glut-ADod)-GLP-1(7-39);
[0680]
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-36)-
;
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-36);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-36);
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ADod)-GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ADod)-GLP-1(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ADod)-GLP-1(7-39);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-36);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ADod)-GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ADod)-GLP-1(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ADod)-GLP-1(7-39);
[0681]
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36(Glut-ADod)-GLP-1(7-36);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36(Glut-ADod)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ADod)-GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ADod)-GLP-1(7-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ADod)-GLP-1(7-39);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-36);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36(Glut-ADod)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ADod)-GLP-1(7-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ADod)-GLP-1(7-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ADod)-GLP-1(7-39);
[0682]
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-36)-
;
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36
Arg.sup.26,34Lys.sup.37-(Glut-ADod)-GLP-1(7-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ADod)-GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ADod)-GLP-1(7-39);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-36);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ADod)-GLP-1(7-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ADod)-GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ADod)-GLP-1(7-39);
[0683]
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-36)-
;
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ADod)-GLP-1(7-37);
Val.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ADod)-GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ADod)-GLP-1(7-39);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-36);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ADod)-GLP-1(7-37);
Val.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ADod)-GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ADod)-GLP-1(7-39);
[0684]
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-36)-
;
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ADod)-GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ADod)-GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ADod)-GLP-1(7-39);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-36);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ADod)-GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ADod)-GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ADod)-GLP-1(7-39);
[0685]
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-36)-
;
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ADod)-GLP-1(7-37);
Ser.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ADod)-GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ADod)-GLP-1(7-39);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-36);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ADod)-GLP-1(7-37);
Ser.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ADod)-GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ADod)-GLP-1(7-39);
[0686]
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-36)-
;
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ADod)-GLP-1(7-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ADod)-GLP-1(7-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ADod)-GLP-1(7-39);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-36);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ADod)-GLP-1(7-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ADod)-GLP-1(7-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ADod)-GLP-1(7-39);
[0687]
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-36)-
;
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ADod)-GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ADod)-GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ADod)-GLP-1(7-39);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-36);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ADod)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ADod)-GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ADod)-GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ADod)-GLP-1(7-39);
[0688] Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-38);
[0689] Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-38);
[0690] Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-38);
[0691] Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-38);
[0692] Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-38);
[0693] Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-38);
[0694] Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-ADod)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-36);
Ser.sup.8Asp.sup.17-Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-38);
[0695] Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-38);
[0696] Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-38);
[0697] Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-ADod)-GLP-1(7-38);
[0698] Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-ADod)-GLP-1(7-38);
[0699] Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-ADod)-GLP-1(7-38);
[0700] Arg.sup.26Lys.sup.34-(Glut-ATet)-GLP-1(7-36);
Arg.sup.34Lys.sup.26-(Glut-ATet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.36-(Glut-ATet)-GLP-1(7-36);
Arg.sup.26Lys.sup.34-(Glut-ATet)-GLP-1(7-36)amide;
Arg.sup.34Lys.sup.26-(Glut-ATet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.36-(Glut-ATet)-GLP-1(7-36)amide;
Arg.sup.26Lys.sup.34-(Glut-ATet)-GLP-1(7-37);
Arg.sup.34Lys.sup.26-(Glut-ATet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.36-(Glut-ATet)-GLP-1(7-37);
Arg.sup.26Lys.sup.34-(Glut-ATet)-GLP-1(7-38);
Arg.sup.34Lys.sup.26-(Glut-ATet)-GLP-1(7-38);
Arg.sup.26,34Lys.sup.34-(Glut-ATet)-GLP-1(7-38);
Arg.sup.26Lys.sup.34-(Glut-ATet)-GLP-1(7-39);
Arg.sup.34Lys.sup.26-(Glut-ATet)-GLP-1(7-39);
Arg.sup.26,34Lys.sup.39-(Glut-ATet)-GLP-1(7-39);
[0701] Gly.sup.8Arg.sup.26Lys.sup.34-(Glut-ATet)-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.26-(Glut-ATet)-GLP-1(7-36);
Gly.sup.8Arg.sup.26,34Lys.sup.36-(Glut-ATet)-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.34-(Glut-ATet)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.34Lys.sup.26-(Glut-ATet)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26,34Lys.sup.36-(Glut-ATet)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26Lys.sup.34-(Glut-ATet)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26-(Glut-ATet)-GLP-1(7-37);
Gly.sup.8Arg.sup.26,34Lys.sup.36-(Glut-ATet)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34-(Glut-ATet)-GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.26-(Glut-ATet)-GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.38-(Glut-ATet)-GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.34-(Glut-ATet)-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.26-(Glut-ATet)-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.39-(Glut-ATet)-GLP-1(7-39);
[0702] Val.sup.8Arg.sup.26Lys.sup.34-(Glut-ATet)-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.26-(Glut-ATet)-GLP-1(7-36);
Val.sup.8Arg.sup.26,34Lys.sup.36-(Glut-ATet)-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.34-(Glut-ATet)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.34Lys.sup.26-(Glut-ATet)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26,34Lys.sup.36-(Glut-ATet)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26Lys.sup.34-(Glut-ATet)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26-(Glut-ATet)-GLP-1(7-37);
Val.sup.8Arg.sup.26,34Lys.sup.36-(Glut-ATet)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34-(Glut-ATet)-GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.26-(Glut-ATet)-GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.38-(Glut-ATet)-GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.34-(Glut-ATet)-GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.26-(Glut-ATet)-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.39-(Glut-ATet)-GLP-1(7-39);
[0703] Ser.sup.8Arg.sup.26Lys.sup.34-(Glut-ATet)-GLP-1(7-36);
Ser.sup.8Arg.sup.34Lys.sup.26-(Glut-ATet)-GLP-1(7-36);
Ser.sup.8Arg.sup.26Lys.sup.39-(Glut-ATet)-GLP-1(7-36);
Ser.sup.8Arg.sup.26Lys.sup.34-(Glut-ATet)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26,34Lys.sup.26-(Glut-ATet)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26,34Lys.sup.36-(Glut-ATet)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26Lys.sup.34-(Glut-ATet)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26-(Glut-ATet)-GLP-1(7-37);
Ser.sup.8Arg.sup.26,34Lys.sup.36-(Glut-ATet)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34-(Glut-ATet)-GLP-1(7-38);
Ser.sup.8Arg.sup.34Lys.sup.26-(Glut-ATet)-GLP-1(7-38);
Ser.sup.8Arg.sup.26,34Lys.sup.38-(Glut-ATet)-GLP-1(7-38);
Ser.sup.8Arg.sup.26Lys.sup.34-(Glut-ATet)-GLP-1(7-39);
Ser.sup.8Arg.sup.34Lys.sup.26-(Glut-ATet)-GLP-1(7-39);
Ser.sup.8Arg.sup.26,34Lys.sup.36-Glut-ATet)-GLP-1(7-39);
[0704] Thr.sup.8Arg.sup.26Lys.sup.34-(Glut-ATet)-GLP-1(7-36);
Thr.sup.8Arg.sup.34Lys.sup.26-(Glut-ATet)-GLP-1(7-36);
Thr.sup.8Arg.sup.26,34Lys.sup.36-(Glut-ATet)-GLP-1(7-36);
Thr.sup.8Arg.sup.26,34Lys.sup.34-(Glut-ATet)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.34Lys.sup.26-(Glut-ATet)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.26,34Lys.sup.36-(Glut-ATet)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.26Lys.sup.34-(Glut-ATet)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26-(Glut-ATet)-GLP-1(7-37);
Thr.sup.8Arg.sup.26,34Lys.sup.36-(Glut-ATet)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34-(Glut-ATet)-GLP-1(7-38);
Thr.sup.8Arg.sup.34Lys.sup.26-(Glut-ATet)-GLP-1(7-38);
Thr.sup.8Arg.sup.26,34Lys.sup.38-(Glut-ATet)-GLP-1(7-38);
Thr.sup.8Arg.sup.26Lys.sup.34-(Glut-ATet)-GLP-1(7-39);
Thr.sup.8Arg.sup.34Lys.sup.26-(Glut-ATet)-GLP-1(7-39);
Thr.sup.8Arg.sup.26,34Lys.sup.39-(Glut-ATet)-GLP-1(7-39);
[0705]
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36(Glut-ATet)-GLP-1(7-36);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ATet)-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Gut-ATet)-GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ATet)
-GLP-1(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ATet)-GLP-1(7-39);
Gly.sup.8Glu.sup.35
Arg.sup.26,34Lys.sup.36-(Glut-ATet)-GLP-1(7-36);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ATet)-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ATet)-GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ATet)-GLP-1(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ATet)-GLP-1(7-39);
[0706]
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ATet)-GLP-1(7-36)-
;
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ATet)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ATet)-GLP-1(7-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ATet)-GLP-1(7-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ATet)-GLP-1(7-39);
Gly.sup.8Asp.sup.35Arg.sup.26,34
Lys.sup.36-(Glut-ATet)-GLP-1(7-36);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ATet)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ATet)-GLP-1(7-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ATet)-GLP-1(7-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ATet)-GLP-1(7-39);
[0707]
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ATet)-GLP-1(7-36)-
;
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ATet)-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ATet)-GLP-1(7-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ATet)-GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ATet)-GLP-1(7-39);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ATet)-GLP-1(7-36);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ATet)-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ATet)-GLP-1(7-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ATet)-GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ATet)-GLP-1(7-39);
[0708]
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ATet)-GLP-1(7-36)-
;
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ATet)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ATet)-GLP-1(7-37);
Val.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ATet)-GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ATet)-GLP-1(7-39);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ATet)-GLP-1(7-36);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ATet)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ATet)-GLP-1(7-37);
Val.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ATet)-GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ATet)-GLP-1(7-39);
[0709]
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ATet)-GLP-1(7-36)-
;
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ATet)-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ATet)-GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ATet)-GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ATet)-GLP-1(7-39);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ATet)-GLP-1(7-36);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ATet-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ATet)-GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ATet)-GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ATet)-GLP-1(7(39);
[0710]
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ATet)-GLP-1(7-36)-
;
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ATet)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ATet)-GLP-1(7-37);
Ser.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ATet)-GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ATet)-GLP-1(7-39);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ATet)-GLP-1(7-36);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ATet)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ATet)-GLP-1(7-37);
Ser.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ATet)-GLP-1(7-38);
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.39-(Glut-ATet)-GLP-1(7-39);
[0711]
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ATet)-GLP-1(7-36)-
;
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36(Glut-ATet)-GLP-1(7-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ATet)-GLP-1(7-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ATet)-GLP-1(7-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ATet)-GLP-1(7-39);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ATet)-GLP-1(7-36);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ATet)-GLP-1(7-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ATet)-GLP-1(7-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ATet)-GLP-1(7-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ATet)-GLP-1(7-39);
[0712]
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ATet)-GLP-1(7-36)-
;
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ATet)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ATet)-GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ATet)-GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ATet)-GLP-1(7-39);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ATet)-GLP-1(7-36);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ATet)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ATet)-GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ATet)-GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ATet)-GLP-1(7-39);
[0713] Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-38);
[0714] Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.34Lys.sup.23-(Glut-ATet)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-38);
[0715] Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Gut-ATet)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-38);
[0716] Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-38);
Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-38);
[0717] Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-38);
[0718] Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-38);
[0719] Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-38);
[0720] Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-38);
[0721] Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-ATet)-GLP-1(7-38);
[0722] Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-ATet)-GLP-1(7-38);
[0723] Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-ATet)-GLP-1(7-38);
[0724] Arg.sup.26Lys.sup.34-(Glut-AHex)-GLP-1(7-36);
Arg.sup.34Lys.sup.26-(Glut-AHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-36);
Arg.sup.26Lys.sup.34-(Glut-AHex)-GLP-1(7-36)amide; Arg.sup.34
Lys.sup.26-(Glut-AHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-36)amide;
Arg.sup.26Lys.sup.34-(Glut-AHex)-GLP-1(7-37);
Arg.sup.34Lys.sup.26-(Glut-AHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-37);
Arg.sup.26Lys.sup.34-(Glut-AHex)-GLP-1(7-38);
Arg.sup.34Lys.sup.26-(Glut-AHex)-GLP-1(7-38);
Arg.sup.26,34Lys.sup.38-(Glut-AHex)-GLP-1(7-38);
Arg.sup.26Lys.sup.34-(Glut-AHex)-GLP-1(7-39);
Arg.sup.34Lys.sup.26-(Glut-AHex)-GLP-1(7-39);
Arg.sup.26,34Lys.sup.39-(Glut-AHex)-GLP-1(7-39);
[0725] Gly.sup.8Arg.sup.26Lys.sup.34-(Glut-AHex)-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.26-(Glut-AHex)-GLP-1(7-36);
Gly.sup.8Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.34-(Glut-AHex)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.34Lys.sup.26-(Glut-AHex)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26,34Lys.sup.36(Glut-AHex)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26Lys.sup.34-(Glut-AHex)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26-(Glut-AHex)-GLP-1(7-37);
Gly.sup.8Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34-(Glut-AHex)-GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.26-(Glut-AHex)-GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.38(Glut-AHex)-GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.34-(Glut-AHex)-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.26-(Glut-AHex)-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.39-(Glut-AHex)-GLP-1(7-39);
[0726] Val.sup.8Arg.sup.26Lys.sup.34-(Glut-AHex)-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.26-(Glut-AHex)-GLP-1(7-36);
Val.sup.8Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.34-(Glut-AHex)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.34Lys.sup.26-(Glut-AHex)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26Lys.sup.34-(Glut-AHex)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26-(Glut-AHex)-GLP-1(7-37);
Val.sup.8Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34-(Glut-AHex)-GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.26-(Glut-AHex)-GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.38-(Glut-AHex)-GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.34-(Glut-AHex)-GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.26-(Glut-AHex)-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.39-(Glut-AHex)-GLP-1(7-39);
[0727] Ser.sup.8Arg.sup.26Lys.sup.34-(Glut-AHex)-GLP-1(7-36);
Ser.sup.8Arg.sup.34Lys.sup.26-(Glut-AHex)-GLP-1(7-36);
Ser.sup.8Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-36);
Ser.sup.8Arg.sup.26Lys.sup.34-(Glut-AHex)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.34Lys.sup.26-(Glut-AHex)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26Lys.sup.34-(Glut-AHex)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26-(Glut-AHex)-GLP-1(7-37);
Ser.sup.8Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34-(Glut-AHex)-GLP-1(7-38);
Ser.sup.8Arg.sup.34Lys.sup.26-(Glut-AHex)-GLP-1(7-38);
Ser.sup.8Arg.sup.26,34Lys.sup.38-(Glut-AHex)-GLP-1(7-38);
Ser.sup.8Arg.sup.26Lys.sup.34-(Glut-AHex)-GLP-1(7-39);
Ser.sup.8Arg.sup.34Lys.sup.26-(Glut-AHex)-GLP-1(7-39);
Ser.sup.8Arg.sup.26,34Lys.sup.39-(Glut-AHex)-GLP-1(7-39);
[0728] Thr.sup.8Arg.sup.26Lys.sup.34-(Glut-AHex)-GLP-1(7-36);
Thr.sup.8Arg.sup.34Lys.sup.26-(Glut-AHex)-GLP-1(7-36);
Thr.sup.8Arg.sup.26,34Lys.sup.36-(Gut-AHex)-GLP-1(7-36);
Thr.sup.8Arg.sup.26Lys.sup.34-(Glut-AHex)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.34Lys.sup.26-(Glut-AHex)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1-(7-36)amide;
Thr.sup.8Arg.sup.26Lys.sup.34-(Glut-AHex)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26-(Glut-AHex)-GLP-1(7-37);
Thr.sup.8Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34-(Glut-AHex)-GLP-1(7-38);
Thr.sup.8Arg.sup.34Lys.sup.26-(Glut-AHex)-GLP-1(7-38);
Thr.sup.8Arg.sup.26,34Lys.sup.38-(Glut-AHex)-GLP-1(7-38);
Thr.sup.8Arg.sup.26Lys.sup.34-(Glut-AHex)-GLP-1(7-39);
Thr.sup.8Arg.sup.34Lys.sup.26-(Glut-AHex)-GLP-1(7-39);
Thr.sup.8Arg.sup.26,34Lys.sup.39-(Glut-AHex)-GLP-1(7-39);
[0729]
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-36)-
;
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glut-AHex)-GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glut-AHex)-GLP-1(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.37-(Glut-AHex)-GLP-1(7-39);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-36);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glut-AHex)-GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glut-AHex)-GLP-1-(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.37-(Glut-AHex)-GLP-1(7-39);
[0730]
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-36)-
;
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glut-AHex)-GLP-1(7-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glut-AHex)-GLP-1(7-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glut-AHex)-GLP-1(7-39);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-36);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glut-AHex)-GLP-1(7-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glut-AHex)-GLP-1(7-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glut-AHex)-GLP-1(7-39);
[0731]
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-36)-
;
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glut-AHex)-GLP-1(7-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glut-AHex)-GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glut-AHex)-GLP-1(7-39);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-36);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glut-AHex)-GLP-1(7-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glut-AHex)-GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glut-AHex)-GLP-1(7-39);
[0732]
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-36)-
;
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glut-AHex)-GLP-1(7-37);
Val.sup.8Asp.sup.37
Arg.sup.26,34Lys.sup.38-(Glut-AHex)-GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glut-AHex)-GLP-1(7-39);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-36);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glut-AHex)-GLP-1(7-37);
Val.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glut-AHex)-GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glut-AHex)-GLP-1(7-39);
[0733]
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-36)-
;
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glut-AHex)-GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glut-AHex)-GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glut-AHex)-GLP-1(7-39);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-36);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glut-AHex)-GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glut-AHex)-GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glut-AHex)-GLP-1(7-39);
[0734]
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-36)-
;
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glut-AHex)-GLP-1(7-37);
Ser.sup.8Arg.sup.26,34Lys.sup.38-(Glut-AHex)-GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glut-AHex)-GLP-1(7-39);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-36);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36(Glut-AHex)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glut-AHex)-GLP-1(7-37);
Ser.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glut-AHex)-GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glut
AHex)-GLP-1(7-39);
[0735]
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-36)-
;
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glut-AHex)-GLP-1(7-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glut-AHex)-GLP-1(7-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glut-AHex)-GLP-1(7-39);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-36);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glut-AHex)-GLP-1(7-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glut-AHex)-GLP-1(7-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glut-AHex)-GLP-1(7-39);
[0736]
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-36)-
;
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glut-AHex)-GLP-1(7-37);
Thr.sup.8Asp.sup.37
Arg.sup.26,34Lys.sup.38-(Glut-AHex)-GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glut-AHex)-GLP-1(7-39);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-36);
Th.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AHex)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glut-AHex)-GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glut-AHex)-GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glut-AHex)-GLP-1(7-39);
[0737] Arg.sup.26,34Lys.sup.18-(Glut-AHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Glut-AHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Glut-AHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Glut-AHex)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-AHex)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-AHex)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-AHex)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-AHex)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-AHex)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-AHex)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-AHex)-GLP-1(7-38);
[0738] Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-AHex)GLP-1(7-36)amide;
Gly.sub.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-38);
[0739] Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34
Lys.sup.27-(Glut-AHex)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-38);
[0740] Arg.sup.26,34Lys.sup.18-(Glut-AHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Glut-AHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Gut-AH x)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Glut-AHex)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-AHex)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-AHex)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-AHex)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-AHex)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-AHex)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-AHex)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-AHex)-GLP-1(7-38);
[0741] Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-38);
[0742] Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-38);
[0743] Arg.sup.26,34Lys.sup.18-(Glut-AHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Glut-AHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Glut-AHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Glut-AHex)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18(Glut-AHex)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-AHex)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-AHex)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18(Glut-AHex)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-AHex)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-AHex)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-AHex)-GLP-1(7-38);
[0744] Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-38);
[0745] Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-38);
[0746] Arg.sup.26,34Lys.sup.18-(Glut-AHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Glut-AHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Glut-AHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Glut-AHex)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-AHex)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-Alex)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-AHex)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-AHex)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-AHex)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-AHex)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-AHex)-GLP-1(7-38);
[0747] Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-AHex)-GLP-1(7-38);
[0748] Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-AHex)-GLP-1(7-38);
[0749] Arg.sup.26Lys.sup.34-(Glut-AOct)-GLP-1(7-36);
Arg.sup.34Lys.sup.26-(Glut-AOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-36);
Arg.sup.26Lys.sup.34-(Glut-AOct)-GLP-1(7-36)amide;
Arg.sup.34Lys.sup.26-(Glut-AOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-36)amide;
Arg.sup.26Lys.sup.34-(Glut-AOct)-GLP-1(7-37);
Arg.sup.34Lys.sup.26-(Glut-AOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-37);
Arg.sup.26Lys.sup.34-(Glut-AOct)-GLP-1(7-38);
Arg.sup.34Lys.sup.26-(Glut-AOct)-GLP-1(7-38);
Arg.sup.26,34Lys.sup.38-(Glut-AOct)-GLP-1(7-38);
Arg.sup.26Lys.sup.34-(Glut-AOct)-GLP-1(7-39);
Arg.sup.34Lys.sup.26-(Glut-AOct)-GLP-1(7-39);
Arg.sup.26,34Lys.sup.39-(Glut-AOct)-GLP-1(7-39);
[0750] Gly.sup.8Arg.sup.26Lys.sup.34-(Glut-AOct)-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.26-(Glut-AOct)-GLP-1(7-36);
Gly.sup.8Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.34-(Glut-AOct)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.34Lys.sup.26-(Glut-AOct)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26Lys.sup.34-(Glut-AOct)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26-(Glut-AOct)-GLP-1(7-37);
Gly.sup.8Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34(Glut-AOct)-GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.26-(Glut-AOct)-GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.38-(Glut-AOct)-GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.34-(Glut-AOct)-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.26-(Glut-AOct)-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.39(Glut-AOct)-GLP-(7-39);
[0751] Val.sup.8Arg.sup.26Lys.sup.34-(Glut-AOct)-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.26-(Glut-AOct)-GLP-1(7-36);
Val.sup.8Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.34-(Glut-AOct)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.34Lys.sup.26-(Glut-AOct)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26 Lys.sup.34-(Glut-AOct)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26-(Glut-AOct)-GLP-1(7-37);
Val.sup.8Arg.sup.26,34Lys.sup.36 (Glut-AOct)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34-(Glut-AOct)-GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.26-(Glut-AOct)-GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.38-(Glut-AOct)-GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.34-(Glut-AOct)-GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.26-(Glut-AOct)-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.39-(Glut-AOct)-GLP-1(7-39);
[0752] Ser.sup.8Arg.sup.26Lys.sup.34-(Glut-AOct)-GLP-1(7-36);
Ser.sup.8Arg.sup.34Lys.sup.26-(Glut-AOct)-GLP-1(7-36);
Ser.sup.8Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-36);
Ser.sup.8Arg.sup.26Lys.sup.34-(Glut-AOct)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.34Lys.sup.26-(Glut-AOct)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26Lys.sup.34-(Glut-AOct)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26-(Glut-AOct)-GLP-1(7-37);
Ser.sup.8Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34-(Glut-AOct)-GLP-1(7-38);
Ser.sup.8Arg.sup.34Lys.sup.26-(Glut-AOct)-GLP-1(7-38);
Ser.sup.8Arg.sup.26,34Lys.sup.38-(Glut-AOct)-GLP-1(7-38);
Ser.sup.8Arg.sup.26Lys.sup.34-(Glut-AOct)-GLP-1(7-39);
Ser.sup.8Arg.sup.34Lys.sup.26-(Glut-AOct)-GLP-1(7-39);
Ser.sup.8Arg.sup.26,34Lys.sup.39-(Glut-AOct)-GLP-1(7-39);
[0753] Thr.sup.8Arg.sup.26Lys.sup.34-(Glut-AOct)-GLP-1(7-36);
Thr.sup.8Arg.sup.34Lys.sup.26-(Glut-AOct)-GLP-1(7-36);
Thr.sup.8Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-36);
Thr.sup.8Arg.sup.26Lys.sup.34-(Glut-AOct)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.34Lys.sup.26-(Glut-AOct)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.26Lys.sup.34-(Glut-AOct)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26-(Glut-AOct)-GLP-1(7-37);
Thr.sup.8Arg.sup.26,34Lys.sup.36(Glut-AOct)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34-(Glut-AOct)-GLP-1(7-38);
Thr.sup.8Arg.sup.34Lys.sup.26-(Glut-AOct)-GLP-1(7-38);
Thr.sup.8Arg.sup.26,34Lys.sup.38-(Glut-AOct)-GLP-1(7-38);
Thr.sup.8Arg.sup.26Lys.sup.34-(Glut-AOct)-GLP-1(7-39);
Thr.sup.8Arg.sup.34Lys.sup.26-(Glut-AOct)-GLP-1(7-39);
Thr.sup.8Arg.sup.26,34Lys.sup.39-(Glut-AOct)-GLP-1(7-39);
[0754]
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-36)-
;
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glut-AOct)-GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glut-AOct)-GLP-1(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glut-AOct)-GLP-1(7-39);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-36);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glut-AOct)-GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glut-AOct)-GLP-1(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glut-AOct)-GLP-1(7-39);
[0755]
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-36)-
;
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glut-AOct)-GLP-1(7-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glut-AOct)-GLP-1(7-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glut-AOct)-GLP-1(7-39);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-36);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glut-AOct)-GLP-1(7-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glut-AOct)-GLP-1(7-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glut-AOct)-GLP-1(7-39);
[0756]
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-36)-
;
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glut-AOct)-GLP-1(7-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.8-(Glut-AOct)-GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glut-AOct)-GLP-1(7-39);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-36);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glut-AOct)-GLP-1(7-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glut-AOct)-GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glut-AOct)-GLP-1(7-39);
[0757]
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-36)-
;
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glut-AOct)-GLP-1(7-37);
Val.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glut-AOct)-GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glut-AOct)-GLP-1(7-39);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-36);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glut-AOct)-GLP-1(7-37);
Val.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glut-AOct)-GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glut-AOct)-GLP-1(7-39);
[0758]
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-36)-
;
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glut-AOct)-GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glut-AOct)-GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glut-AOct)-GLP-1(7-39);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-36);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glut-AOct)-GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glut-AOct)-GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glut-AOct)-GLP-1(7-39);
[0759]
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-36)-
;
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glut-AOct)-GLP-1(7-37);
Ser.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glut-AOct)-GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glut-AOct)-GLP-1(7-39);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-36);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glut-AOct)-GLP-1(7-37);
Ser.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glut-AOct)-GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glut-AOct)-GLP-1(7-39);
[0760]
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-36)-
;
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glut-AOct)-GLP-1(7-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glut-AOct)-GLP-1(7-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glut-AOct)-GLP-1(7-39);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-36);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glut-AOct)-GLP-1(7-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glut-AOct)-GLP-1(7-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glut-AOct)-GLP-1(7-39);
[0761]
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-36)-
;
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glut-AOct)-GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glut-AOct)-GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glut-AOct)-GLP-1(7-39);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-36);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-AOct)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glut-AOct)-GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glut-AOct)-GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glut-AOct)-GLP-1(7-39);
[0762] Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18(Glut-AOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-38);
[0763] Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-38);
Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-38);
[0764] Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-38);
[0765] Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-38);
[0766] Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-38);
[0767] Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-38);
[0768] Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-38);
[0769] Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-38);
[0770] Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-AOct)-GLP-1(7-38);
[0771] Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.33-(Glut-AOct)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-AOct)-GLP-1(7-38);
[0772] Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-AOct)-GLP-1(7-38);
[0773] Arg.sup.26Lys.sup.34-(Glut-ALit)-GLP-1(7-36);
Arg.sup.34Lys.sup.26-(Glut-ALit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-36);
Arg.sup.26Lys.sup.34-(Glut-ALit)-GLP-1(7-36)amide;
Arg.sup.34Lys.sup.26-(Glut-ALit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-36)amide;
Arg.sup.26Lys.sup.34-(Glut-ALit)-GLP-1(7-37);
Arg.sup.34Lys.sup.26-(Glut-ALit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-37);
Arg.sup.26Lys.sup.34-(Glut-ALit)-GLP-1(7-38);
Arg.sup.34Lys.sup.26-(Glut-ALit)-GLP-1(7-38);
Arg.sup.26,34Lys.sup.38-(Glut-ALit)-GLP-1(7-38);
Arg.sup.26Lys.sup.34-(Glut-ALit)-GLP-1(7-39);
Arg.sup.34Lys.sup.26-(Glut-ALit)-GLP-1(7-39);
Arg.sup.26,34Lys.sup.39-(Glut-ALit)-GLP-1(7-39);
[0774] Gly.sup.8Arg.sup.26Lys.sup.34-(Glut-ALit)-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.26-(Glut-ALit)-GLP-1(7-36);
Gly.sup.8Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.34-(Glut-ALit)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.34Lys.sup.26-(Glut-ALit)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26Lys.sup.34-(Glut-ALit)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26-(Glut-ALit)-GLP-1(7-37);
Gly.sup.8Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34-(Glut-ALit)-GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.26-(Glut-ALit)-GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.38-(Glut-ALit)-GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.34-(Glut-ALit)-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.26-(Glut-ALit)-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.39-(Glut-ALit)-GLP-1(7-39);
[0775] Val.sup.8Arg.sup.26Lys.sup.34-(Glut-ALit)-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.26-(Glut-ALit)-GLP-1(7-36);
Val.sup.8Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.34-(Glut-ALit)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.34Lys.sup.26-(Glut-ALit)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26Lys.sup.34-(Glut-ALit)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26-(Glut-ALit)-GLP-1(7-37);
Val.sup.8Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34-(Glut-ALit)-GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.26-(Glut-ALit)-GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.38-(Glut-ALit)-GLP-1-(7-38);
Val.sup.8Arg.sup.26Lys.sup.34-(Glut-ALit)-GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.26-(Glut-ALit)-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.39-(Glut-ALit)-GLP-1(7-39);
[0776] Ser.sup.8Arg.sup.26Lys.sup.34-(Glut-ALit)-GLP-1(7-36);
Ser.sup.8Arg.sup.34Lys.sup.26-(Glut-ALit)-GLP-1(7-36);
Ser.sup.8Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-36);
Ser.sup.8Arg.sup.26Lys.sup.34-(Glut-ALit)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.34Lys.sup.26-(Glut-ALit)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26Lys.sup.34-(Glut-ALit)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26-(Glut-ALit)-GLP-1(7-37);
Ser.sup.8Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34-(Glut-ALit)-GLP-1(7-38);
Ser.sup.8Arg.sup.34Lys.sup.26-(Glut-ALit)-GLP-1(7-38);
Ser.sup.8Arg.sup.26,34Lys.sup.38-(Glut-ALit)-GLP-1(7-38);
Ser.sup.8Arg.sup.26Lys.sup.34-(Glut-ALit)-GLP-1(7-39);
Ser.sup.8Arg.sup.34Lys.sup.26-(Glut-ALit)-GLP-1(7-39);
Ser.sup.8Arg.sup.26,34Lys.sup.39-(Glut-ALit)-GLP-1(7-39);
[0777] Thr.sup.8Arg.sup.26Lys.sup.34-(Glut-ALit)-GLP-1(7-36);
Thr.sup.8Arg.sup.34Lys.sup.26-(Glut-ALit)-GLP-1(7-36);
Thr.sup.8Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-36);
Thr.sup.8Arg.sup.26Lys.sup.34-(Glut-ALit)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.34Lys.sup.26-(Glut-ALit)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.26Lys.sup.34-(Glut-ALit)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26-(Glut-ALit)-GLP-1(7-37);
Thr.sup.8Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34-(Glut-ALit)-GLP-1(7-38);
Thr.sup.8Arg.sup.34Lys.sup.26-(Glut-ALit)-GLP-1(7-38);
Thr.sup.8Arg.sup.26,34Lys.sup.38-(Glut-ALit)-GLP-1(7-38);
Thr.sup.8Arg.sup.26Lys.sup.34-(Glut-ALit)-GLP-1(7-39);
Thr.sup.8Arg.sup.34Lys.sup.26-(Glut-ALit)-GLP-1(7-39);
Thr.sup.8Arg.sup.26,34Lys.sup.39-(Glut-ALit)-GLP-1(7-39);
[0778]
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-36)-
;
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ALit)-GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ALit)-GLP-1(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ALit)-GLP-1(7-39);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-36);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ALit)-GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ALit)-GLP-1(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ALit)-GLP-1(7-39);
[0779]
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-36)-
;
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ALit)-GLP-1(7-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ALit)-GLP-1(7-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ALit)-GLP-1(7-39);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-36);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ALit)-GLP-1(7-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ALit)-GLP-1(7-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ALit)-GLP-1(7-39);
[0780]
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-36)-
;
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ALit)-GLP-1(7-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ALit)-GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ALit)-GLP-1(7-39);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-36);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ALit)-GLP-1(7-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ALit)-GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ALit)-GLP-1(7-39);
[0781]
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-36)-
;
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ALit)-GLP-1(7-37);
Val.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ALit)-GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ALit)-GLP-1(7-39);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-36);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ALit)-GLP-1(7-37);
Val.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ALit)-GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ALit)-GLP-1(7-39);
[0782]
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-36)-
;
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ALit)-GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ALit)-L-GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ALit)-GLP-1(7-39);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-36);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ALit)-GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ALit)-GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ALit)-GLP-1(7-39);
[0783]
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-36)-
;
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ALit)-GLP-1(7-37);
Ser.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ALit)-GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ALit)-GLP-1(7-39);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-36);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ALit)-GLP-1(7-37);
Ser.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ALit)-GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ALit)-GLP-1(7-39);
[0784]
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-36)-
;
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ALit)-GLP-1(7-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ALit)-GLP-1(7-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ALit)-GLP-1(7-39);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-36);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ALit)-GLP-1(7-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ALit)-GLP-1(7-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ALit)-GLP-1(7-39);
[0785]
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-36)-
;
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.39-(Glut-ALit)-GLP-1(7-39);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.38-(Glut-ALit)-GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ALit)-GLP-1(7-39);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-36);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glut-ALit)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glut-ALit)-GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glut-ALit)-GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glut-ALit)-GLP-1(7-39);
[0786] Arg.sup.26,34Lys.sup.18-(Glut-ALit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Glut-ALit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Glut-ALit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Glut-ALit)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ALit)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-ALit)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ALit)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-ALit)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ALit)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ALit)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-ALit)-GLP-1(7-38);
[0787] Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-38);
[0788] Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27(Glut-ALit)-GLP-1(7-38);
[0789] Arg.sup.26,34Lys.sup.18-(Glut-ALit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Glut-ALit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Glut-ALit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Glut-ALit)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18(Glut-ALit)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-ALit)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ALit)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-ALit)-(Glut-ALit)-GLP-1(-
7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ALit)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ALit)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-ALit)-GLP-1(7-38);
[0790] Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-38);
[0791] Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-38);
[0792] Arg.sup.26,34Lys.sup.18-(Glut-ALit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Glut-ALit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Glut-ALit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.1-(Glut-ALit)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34
Lys.sup.18-(Glut-ALit)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-ALit)-GLP-1(7-36);
Ser.sup.8Asp.sup.9Arg.sup.26,34Lys.sup.18-(Glut-ALit)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-ALit)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ALit)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ALit)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-ALit)-GLP-1(7-38);
[0793] Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-36)
Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-38);
[0794] Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-38);
[0795] Arg.sup.26,34Lys.sup.18-(Glut-ALit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Glut-ALit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Glut-ALit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Glut-ALit)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ALit)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-ALit)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ALit)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-ALit)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ALit)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glut-ALit)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glut-ALit)-GLP-1(7-38);
[0796] Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glut-ALit)-GLP-1(7-38);
[0797] Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glut-ALit)-GLP-1(7-38);
[0798] Arg.sup.26Lys.sup.34-(Aspa-ADod)-GLP-1(7-36);
Arg.sup.34Lys.sup.26-(Aspa-ADod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-36);
Arg.sup.26Lys.sup.341-(Aspa-ADod)-GLP-1(7-36)amide;
Arg.sup.34Lys.sup.26-(Aspa-ADod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-36)amide;
Arg.sup.26Lys.sup.34-(Aspa-ADod)-GLP-1(7-37);
Arg.sup.34Lys.sup.26-(Aspa-ADod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-37);
Arg.sup.26Lys.sup.34-(Aspa-ADod)-GLP-1(7-38);
Arg.sup.34Lys.sup.26-(Aspa-ADod)-GLP-1(7-38);
Arg.sup.26,34Lys.sup.38-(Aspa-ADod)-GLP-1(7-38);
Arg.sup.26Lys.sup.34-(Aspa-ADod)-GLP-1(7-39);
Arg.sup.34Lys.sup.26-(Aspa-ADod)-GLP-1(7-39);
Arg.sup.26,34Lys.sup.39-(Aspa-ADod)-GLP-1(7-39);
[0799] Gly.sup.8Arg.sup.26Lys.sup.34-(Aspa-ADod)-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.26-(Aspa-ADod)-GLP-1(7-36);
Gly.sup.8Arg.sup.26,34 Lys.sup.36-(Aspa-ADod)-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.34-(Aspa-ADod)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.34Lys.sup.26-(Aspa-ADod)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26Lys.sup.34-(Aspa-ADod)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26-(Aspa-ADod)-GLP-1(7-37);
Gly.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34-(Aspa-ADod)-GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.26-(Aspa-ADod)-GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.38-(Aspa-ADod)-GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.34-(Aspa-ADod)-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.26-(Aspa-ADod)-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.39-(Aspa-ADod)-GLP-1(7-39);
[0800] Val.sup.8Arg.sup.26Lys.sup.34-(Aspa-ADod)-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.26-(Aspa-ADod)-GLP-1(7-36);
Val.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.34-(Aspa-ADod)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.34Lys.sup.26-(Aspa-ADod)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26Lys.sup.34-(Aspa-ADod)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26-(Aspa-ADod)-GLP-1(7-37);
Val.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34-(Aspa-ADod)-GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.26-(Aspa-ADod)-GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.38-(Aspa-ADod)-GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.34-(Aspa-ADod)-GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.26-(Aspa-ADod)-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.39-(Aspa-ADod)-GLP-1(7-39);
[0801] Ser.sup.8Arg.sup.26Lys.sup.34-(Aspa-ADod)-GLP-1(7-36);
Ser.sup.8Arg.sup.34Lys.sup.26-(Aspa-ADod)-GLP-1(7-36);
Ser.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-36);
Ser.sup.8Arg.sup.26Lys.sup.34-(Aspa-ADod)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.34Lys.sup.26-(Aspa-ADod)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26Lys.sup.34-(Aspa-ADod)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26-(Aspa-ADod)-GLP-1(7-37);
Ser.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-37)
Ser.sup.8Arg.sup.26Lys.sup.34-(Aspa-ADod)-GLP-1(7-38);
Ser.sup.8Arg.sup.34Lys.sup.26-(Aspa-ADod)-GLP-1(7-38);
Ser.sup.8Arg.sup.26,34Lys.sup.38-(Aspa-ADod)-GLP-1(7-38);
Ser.sup.8Arg.sup.26Lys.sup.34-(Aspa-ADod)-GLP-1(7-39);
Ser.sup.8Arg.sup.34Lys.sup.26-(Aspa-ADod)-GLP-1(7-39);
Ser.sup.8Arg.sup.26,34Lys.sup.39-(Aspa-ADod)-GLP-1(7-39);
[0802] Thr.sup.8Arg.sup.26 Lys.sup.34-(Aspa-ADod)-GLP-1(7-36);
Thr.sup.8Arg.sup.34Lys.sup.26-(Aspa-ADod)-GLP-1(7-36);
Thr.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-36);
Thr.sup.8Arg.sup.26Lys.sup.34-(Aspa-ADod)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.34Lys.sup.26-(Aspa-ADod)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.26Lys.sup.34-(Aspa-ADod)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26-(Aspa-ADod)-GLP-1(7-37);
Thr.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34-(Aspa-ADod)-GLP-1(7-38);
Thr.sup.8Arg.sup.34Lys.sup.26-(Aspa-ADod)-GLP-1(7-38);
Thr.sup.8Arg.sup.26,34Lys.sup.38-(Aspa-ADod)-GLP-1(7-38);
Thr.sup.8Arg.sup.26Lys.sup.34-(Aspa-ADod)-GLP-1(7-39);
Thr.sup.8Arg.sup.34Lys.sup.26-(Aspa-ADod)-GLP-1(7-39);
Thr.sup.8Arg.sup.26,34Lys.sup.39-(Aspa-ADod)-GLP-1(7-39);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-36);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ADod)-GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ADod)-GLP-1(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ADod)-GLP-1(7-39);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-36);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ADod)-GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ADod)-GLP-1(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ADod)-GLP-1(7-39);
[0803]
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-36)-
;
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36(Aspa-ADod)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ADod)-GLP-1(7-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ADod)-GLP-1(7-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ADod)-GLP-1(7-39);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-36);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ADod)-GLP-1(7-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ADod)-GLP-1(7-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ADod)-GLP-1(7-39);
[0804]
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-36)-
;
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ADod)-GLP-1(7-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ADod)-GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ADod)-GLP-1(7-39);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-36);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37(Aspa-ADod)-GLP-1(7-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ADod)-GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34
Lys.sup.39-(Aspa-ADod)-GLP-1(7-39);
[0805]
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-36)-
;
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ADod)-GLP-1(7-37);
Val.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ADod)-GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ADod)-GLP-1(7-39);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36(Aspa-ADod)-GLP-1(7-36);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ADod)-GLP-1(7-37);
Val.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ADod)-GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ADod)-GLP-1(7-39);
[0806]
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-36)-
;
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ADod)-GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ADod)-GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ADod)-GLP-1(7-39);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-36);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ADod)-GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ADod)-GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ADod)-GLP-1(7-39);
[0807]
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-36)-
;
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ADod)-GLP-1(7-37);
Ser.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ADod)-GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ADod)-GLP-1(7-39);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-36);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ADod)-GLP-1(7-37);
Ser.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ADod)-GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ADod)-GLP-1(7-39);
[0808]
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-36)-
;
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ADod)-GLP-1(7-37);
Thr.sup.8Glu.sup.3Arg.sup.26,34Lys.sup.38-(Aspa-ADod)-GLP-1(7-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ADod)-GLP-1(7-39);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-36);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ADod)-GLP-1(7-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34
Lys.sup.38-(Aspa-ADod)-GLP-1(7-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ADod)-GLP-1(7-39);
[0809]
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-36)-
;
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ADod)-GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ADod)-GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ADod)-GLP-1(7-39);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-36);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ADod)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ADod)-GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ADod)-GLP-1(7-38);
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.39-(Aspa-ADod)-GLP-1(7-39);
[0810] Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-38);
[0811] Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-38);
[0812] Arg.sup.26,34Lys.sup.27-(Aspa-ADod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Aspa-ADod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Aspa-ADod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Aspa-ADod)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ADod)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-ADod)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ADod)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-ADod)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ADod)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ADod)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-ADod)-GLP-1(7-38);
[0813] Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-38);
[0814] Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-38);
[0815] Arg.sup.26,34Lys.sup.27-(Aspa-ADod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Aspa-ADod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Aspa-ADod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Aspa-ADod)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ADod)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-ADod)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ADod)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-ADod)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ADod)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ADod)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-ADod)-GLP-1(7-38);
[0816] Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-38);
[0817] Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17
Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-38);
[0818] Arg.sup.26,34Lys.sup.27-(Aspa-ADod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27(Aspa-ADod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Aspa-ADod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Aspa-ADod)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ADod)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-ADod)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ADod)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-ADod)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ADod)-GLP-1(7-37);
Ser.sup.1Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ADod)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34
Lys.sup.27-(Aspa-ADod)-GLP-1(7-38);
[0819] Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-ADod)-GLP-1(7-38);
[0820] Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-ADod)-GLP-1(7-38);
[0821] Arg.sup.26,34Lys.sup.27-(Aspa-ADod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Aspa-ADod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Aspa-ADod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Aspa-ADod)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ADod)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-ADod)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ADod)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-ADod)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ADod)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ADod)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-ADod)-GLP-1(7-38);
[0822] Arg.sup.26Lys.sup.34-(Aspa-ATet)-GLP-1(7-36);
Arg.sup.34Lys.sup.26-(Aspa-ATet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1(7-36);
Arg.sup.26Lys.sup.34-(Aspa-ATet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.26-(Aspa-ATet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1(7-36)amide;
Arg.sup.26Lys.sup.34-(Aspa-ATet)-GLP-1(7-37);
Arg.sup.34Lys.sup.26-(Aspa-ATet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1(7-37);
Arg.sup.26Lys.sup.34-(Aspa-ATet)-GLP-1(7-38);
Arg.sup.34Lys.sup.26-(Aspa-ATet)-GLP-1(7-38);
Arg.sup.26,34Lys.sup.38-(Aspa-ATet)-GLP-1(7-38);
Arg.sup.26Lys.sup.34-(Aspa-ATet)-GLP-1(7-39);
Arg.sup.34Lys.sup.26-(Aspa-ATet)-GLP-1(7-39);
Arg.sup.26,34Lys.sup.39-(Aspa-ATet)-GLP-1(7-39);
[0823] Gly.sup.8Arg.sup.26Lys.sup.34-(Aspa-ATet)-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.26-(Aspa-ATet)-GLP-1(7-36);
Gly.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.34-(Aspa-ATet)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.34Lys.sup.26-(Aspa-ATet)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26Lys.sup.34-(Aspa-ATet)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26-(Aspa-ATet)-GLP-1(7-37);
Gly.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34-(Aspa-ATet)-GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.26-(Aspa-ATet)-GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.38-(Aspa-ATet)-GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.34-(Aspa-ATet)-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.26-(Aspa-ATet)-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.39-(Aspa-ATet)-GLP-1(7-39);
[0824] Val.sup.8Arg.sup.26Lys.sup.34-(Aspa-ATet)-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.26-(Aspa-ATet)-GLP-1(7-36);
Val.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.34-(Aspa-ATet)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.34Lys.sup.26-(Aspa-ATet)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26Lys.sup.34-(Aspa-ATet)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26-(Aspa-ATet)-GLP-1(7-37);
Val.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34-(Aspa-ATet)-GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.26-(Aspa-ATet)-GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.38-(Aspa-ATet)-GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.34-(Aspa-ATet)-GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.26-(Aspa-ATet)-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.39-(Aspa-ATet)-GLP-1(7-39);
[0825] Ser.sup.8Arg.sup.26Lys.sup.34-(Aspa-ATet)-GLP-1(7-36);
Ser.sup.8Arg.sup.34Lys.sup.26-(Aspa-ATet)-GLP-1(7-36);
Ser.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1(7-36);
Ser.sup.8Arg.sup.26Lys.sup.34-(Aspa-ATet)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.34Lys.sup.26-(Aspa-ATet)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26Lys.sup.34-(Aspa-ATet)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26-(Aspa-ATet)-GLP-1(7-37);
Ser.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34-(Aspa-ATet)-GLP-1(7-38);
Ser.sup.8Arg.sup.34Lys.sup.26-(Aspa-ATet)-GLP-1(7-38);
Ser.sup.8Arg.sup.26,34Lys.sup.38-(Aspa-ATet)-GLP-1(7-38);
Ser.sup.8Arg.sup.26Lys.sup.34-(Aspa-ATet)-GLP-1(7-39);
Ser.sup.8Arg.sup.34Lys.sup.26-(Aspa-ATet)-GLP-1(7-39);
Ser.sup.8Arg.sup.26,34Lys.sup.39-(Aspa-ATet)-GLP-1(7-39);
[0826] Thr.sup.8Arg.sup.26Lys.sup.34-(Aspa-ATet)-GLP-1(7-36);
Thr.sup.8Arg.sup.34Lys.sup.26-(Aspa-ATet)-GLP-1(7-36);
Thr.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1(7-36);
Thr.sup.8Arg.sup.26Lys.sup.34-(Aspa-ATet)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.34Lys.sup.26-(Aspa-ATet)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.26Lys.sup.34-(Aspa-ATet)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26-(Aspa-ATet)-GLP-1(7-37);
Thr.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34-(Aspa-ATet)-GLP-1(7-38);
Thr.sup.8Arg.sup.34Lys.sup.26-(Aspa-ATet)-GLP-1(7-38);
Thr.sup.8Arg.sup.26,34Lys.sup.38-(Aspa-ATet)-GLP-1(7-38);
Thr.sup.8Arg.sup.26Lys.sup.34-(Aspa-ATet)-GLP-1(7-39);
Thr.sup.8Arg.sup.34Lys.sup.26-(Aspa-ATet)-GLP-1(7-39);
Thr.sup.8Arg.sup.26,34Lys.sup.39-(Aspa-ATet)-GLP-1(7-39);
[0827]
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1(7-36)-
;
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ATet)-GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ATet)-GLP-1(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ATet)-GLP-1(7-39);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1(7-36);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36(Aspa-ATet)-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ATet)-GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ATet)-GLP-1(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39(Aspa-ATet)
GLP-1(7-39);
[0828]
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1((7-36-
);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36(Aspa-ATet)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ATet)-GLP-1(7-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ATet)-GLP-1(7-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ATet)-GLP-1(7-39);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1(7-36);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36(Aspa-ATet)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ATet)-GLP-1(7-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ATet)-GLP-1(7-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ATet)-GLP-1(7-39);
[0829]
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1(7-36)-
;
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ATet)-GLP-1(7-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ATet)-GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ATet)-GLP-1(7-39);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36(Aspa-ATet)-GLP-1(7-36);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ATet)-GLP-1(7-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ATet)-GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ATet)-GLP-1(7-39);
[0830]
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1(7-36)-
;
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ATet)-GLP-1(7-37);
Val.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ATet)-GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ATet)-GLP-1(7-39);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1(7-36);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ATet)-GLP-1(7-37);
Val.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ATet)-GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ATet)-GLP-1(7-39);
[0831]
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1(7-36)-
;
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ATet)-GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sub.38-(Aspa-ATet)-GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ATet)-GLP-1(7-39);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1(7-36);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ATet)-GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ATet)-GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ATet)-GLP-1(7-39);
[0832]
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1(7-36)-
;
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ATet)-GLP-1(7-37);
Ser.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ATet)-GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ATet)-GLP-1(7-39);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1(7-36);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ATet)-GLP-1(7-37);
Ser.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ATet)-GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ATet)-GLP-1(7-39);
[0833]
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1(7-36)-
;
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1(7-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ATet)-GLP-1(7-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ATet)-GLP-1(7-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ATet)-GLP-1(7-39);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1(7-36);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1(7-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ATet)-GLP-1(7-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ATet)-GLP-1(7-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ATet)-GLP-1(7-39);
[0834]
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1(7-36)-
;
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ATet)-GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ATet)-GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ATet)-GLP-1(7-39);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1(7-36);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ATet)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ATet)-GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ATet)-GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ATet)-GLP-1(7-39);
[0835] Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-38);
[0836] Arg.sup.26,34Lys.sup.23-(Aspa-ATet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23(Aspa-ATet)-GLP-1(7-36)amide
Arg.sup.26,34Lys.sup.23-(Aspa-ATet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Aspa-ATet)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ATet)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-ATet)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ATet)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-ATet)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ATet)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ATet)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-ATet)-GLP-1(7-38);
[0837] Arg.sup.26,34Lys.sup.27-(Aspa-ATet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Aspa-ATet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Aspa-ATet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Aspa-ATet)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ATet)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-ATet)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ATet)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-ATet)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ATet)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ATet)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-ATet)-GLP-1(7-38);
[0838] Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-38);
[0839] Arg.sup.26,34Lys.sup.23-(Aspa-ATet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Aspa-ATet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Aspa-ATet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Aspa-ATet)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ATet)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-ATet)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ATet)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-ATet)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ATet)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ATet)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-ATet)-GLP-1(7-38);
[0840] Arg.sup.26,34Lys.sup.27-(Aspa-ATet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Aspa-ATet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Aspa-ATet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Aspa-ATet)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ATet)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-ATet)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ATet)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-ATet)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ATet)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ATet)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-ATet)-GLP-1(7-38);
[0841] Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-38);
[0842] Arg.sup.26,34Lys.sup.23-(Aspa-ATet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Aspa-ATet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Aspa-ATet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Aspa-ATet)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ATet)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-ATet)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ATet)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.3-(Aspa-ATet)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ATet)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ATet)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-ATet)-GLP-1(7-38);
[0843] Arg.sup.26,34Lys.sup.27-(Aspa-ATet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Aspa-ATet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Aspa-ATet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Aspa-ATet)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ATet)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34
Lys.sup.27-(Aspa-ATet)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ATet)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-ATet)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ATet)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ATet)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-ATet)-GLP-1(7-38);
[0844] Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-ATet)-GLP-1(7-38);
[0845] Arg.sup.26,34Lys.sup.23-(Aspa-ATet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Aspa-ATet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Aspa-ATet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Aspa-ATet)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ATet)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-ATet)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ATet)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-ATet)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ATet)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ATet)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-ATet)-GLP-1(7-38);
[0846] Arg.sup.26,34Lys.sup.27-(Aspa-ATet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Aspa-ATet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Aspa-ATet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Aspa-ATet)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ATet)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34
Lys.sup.27-(Aspa-ATet)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ATet)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-ATet)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ATet)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ATet)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-ATet)-GLP-1(7-38);
[0847] Arg.sup.26Lys.sup.34-(Aspa-AHex)-GLP-1(7-36);
Arg.sup.34Lys.sup.26-(Aspa-AHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-36);
Arg.sup.26Lys.sup.34-(Aspa-AHex)-GLP-1(7-36)amide;
Arg.sup.34Lys.sup.26-(Aspa-AHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-36)amide;
Arg.sup.26Lys.sup.34-(Aspa-AHex)-GLP-1(7-37);
Arg.sup.34Lys.sup.26-(Aspa-AHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-37);
Arg.sup.26Lys.sup.34-(Aspa-AHex)-GLP-1(7-38);
Arg.sup.34Lys.sup.26-(Aspa-AHex)-GLP-1(7-38);
Arg.sup.26,34Lys.sup.38-(Aspa-AHex)-GLP-1(7-38);
Arg.sup.26Lys.sup.34-(Aspa-AHex)-GLP-1(7-39);
Arg.sup.34Lys.sup.26-(Aspa-AHex)-GLP-1(7-39);
Arg.sup.26,34Lys.sup.39-(Aspa-AHex)-GLP-1(7-39);
[0848] Gly.sup.8Arg.sup.26Lys.sup.34-(Aspa-AHex)-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.26-(Aspa-AHex)-GLP-1(7-36);
Gly.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.34-(Aspa-AHex)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.34Lys.sup.26-(Aspa-AHex)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26Lys.sup.34-(Aspa-AHex)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26-(Aspa-AHex)-GLP-1(7-37);
Gly.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34-(Aspa-AHex)-GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.26-(Aspa-AHex)-GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.38-(Aspa-AHex)-GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.34-(Aspa-AHex)-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.26-(Aspa-AHex)-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.39-(Aspa-AHex)-GLP-1(7-39);
[0849] Val.sup.8Arg.sup.26Lys.sup.34-(Aspa-AHex)-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.26-(Aspa-AHex)-GLP-1(7-36);
Val.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.34-(Aspa-AHex)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.34Lys.sup.26-(Aspa-AHex)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26Lys.sup.34-(Aspa-AHex)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26-(Aspa-AHex)-GLP-1(7-37);
Val.sup.8Arg.sup.26,36Lys.sup.36-(Aspa-AHex)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34-(Aspa-AHex)-GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.26-(Aspa-AHex)-GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.38-(Aspa-AHex)-GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.34-(Aspa-AHex)-GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.26-(Aspa-AHex)-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.39-(Aspa-AHex)-GLP-1(7-39);
[0850] Ser.sup.8Arg.sup.26Lys.sup.34-(Aspa-AHex)-GLP-1(7-36);
Ser.sup.8Arg.sup.34Lys.sup.26-(Aspa-AHex)-GLP-1(7-36);
Ser.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-36);
Ser.sup.8Arg.sup.26Lys.sup.34-(Aspa-AHex)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.34Lys.sup.26-(Aspa-AHex)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26Lys.sup.34-(Aspa-AHex)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26-(Aspa-AHex)-GLP-1(7-37);
Ser.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34-(Aspa-AHex)-GLP-1(7-38);
Ser.sup.8Arg.sup.34Lys.sup.26-(Aspa-AHex)-GLP-1(7-38);
Ser.sup.8Arg.sup.26,34Lys.sup.38-(Aspa-AHex)-GLP-1(7-38);
Ser.sup.8Arg.sup.26Lys.sup.34-(Aspa-AHex)-GLP-1(7-39);
Ser.sup.8Arg.sup.34Lys.sup.26-(Aspa-AHex)-GLP-1(7-39);
Ser.sup.8Arg.sup.26,34Lys.sup.39(Aspa-AHex)-GLP-1(7-39);
[0851] Thr.sup.8Arg.sup.26Lys.sup.34-(Aspa-AHex)-GLP-1(7-36);
Thr.sup.8Arg.sup.34Lys.sup.26-(Aspa-AHex)-GLP-1(7-36);
Thr.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-36);
Thr.sup.8Arg.sup.26Lys.sup.34-(Aspa-AHex)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.34Lys.sup.26-(Aspa-AHex)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.26Lys.sup.34(Aspa-AHex)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26(Aspa-AHex)-GLP-1(7-37);
Thr.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34(Aspa-AHex)-GLP-1(7-38);
Thr.sup.8Arg.sup.34Lys.sup.26-(Aspa-AHex)-GLP-1(7-38);
Thr.sup.8Arg.sup.26,34Lys.sup.38(Aspa-AHex)-GLP-1(7-38);
Thr.sup.8Arg.sup.26Lys.sup.34-(Aspa-AHex)-GLP-1(7-39);
Thr.sup.8Arg.sup.34Lys.sup.26-(Aspa-AHex)-GLP-1(7-39);
Thr.sup.8Arg.sup.26,34Lys.sup.39-(Aspa-AHex)-GLP-1(7-39);
[0852]
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-36)-
;
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-AHex)-GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-AHex)-GLP-1(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-AHex)-GLP-(1(7-39);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-36);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37(Aspa-AHex)-GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38(Aspa-AHex)-GLP-1(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-AHex)-GLP-1(7-39);
[0853]
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-36)-
;
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-AHex)-GLP-1(7-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-AHex)-GLP-1(7-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-AHex)-GLP-1(7-39);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-36);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-AHex)-GLP-1(7-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-AHex)-GLP-1(7-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-AHex)-GLP-1(7-39);
[0854]
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-36)-
;
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-AHex)-GLP-1(7-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-AHex)-GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-AHex)-GLP-1(7-39);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-36);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-AHex)-GLP-1(7-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-AHex)-GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-AHex)-GLP-1(7-39);
[0855]
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-36)-
;
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-AHex)-GLP-1(7-37);
Val.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-AHex)-GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-AHex)-GLP-1(7-39);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-36);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-AHex)-GLP-1(7-37);
Val.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-AHex)-GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-AHex)-GLP-1(7-39);
[0856]
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-36)-
;
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-AHex)-GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-AHex)-GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-AHex)-GLP-1(7-39);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-36);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-AHex)-GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-AHex)-GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-AHex)-GLP-1(7-39);
[0857]
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-36)-
;
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-AHex)-GLP-1(7-37);
Ser.sup.8Arg.sup.26,34Lys.sup.38-(Aspa-AHex)-GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-AHex)-GLP-1(7-39);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-36);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-AHex)-GLP-1(7-37);
Ser.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-AHex)-GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-AHex)-GLP-1(7-39);
[0858]
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-36)-
;
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-AHex)-GLP-1(7-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-AHex)-GLP-1(7-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-AHex)-GLP-1(7-39);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-36);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-AHex)-GLP-1(7-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-AHex)-GLP-1(7-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-AHex)-GLP-1(7-39);
[0859]
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-36)-
;
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-AHex)-GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-AHex)-GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-AHex)-GLP-1(7-39);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-36);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AHex)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-AHex)-GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-AHex)-GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-AHex)-GLP-1(7-39);
[0860] Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-38);
[0861] Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-38);
[0862] Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-38);
[0863] Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-38);
[0864] Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-38);
[0865] Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-38);
[0866] Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-38);
[0867] Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-38);
[0868] Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-38);
[0869] Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-AHex)-GLP-1(7-38);
[0870] Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-AHex)-GLP-1(7-38);
[0871] Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-AHex)-GLP-1(7-38);
[0872] Arg.sup.26Lys.sup.34-(Aspa-AOct)-GLP-1(7-36);
Arg.sup.34Lys.sup.26-(Aspa-AOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-36);
Arg.sup.26Lys.sup.34-(Aspa-AOct)-GLP-1(7-36)amide;
Arg.sup.34Lys.sup.26-(Aspa-AOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-36)amide;
Arg.sup.26Lys.sup.34-(Aspa-AOct)-GLP-1(7-37);
Arg.sup.34Lys.sup.26-(Aspa-AOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-37);
Arg.sup.26Lys.sup.34-(Aspa-AOct)-GLP-1(7-38);
Arg.sup.34Lys.sup.26-(Aspa-AOct)-GLP-1(7-38);
Arg.sup.26,34Lys.sup.38-(Aspa-AOct)-GLP-1(7-38);
Arg.sup.26Lys.sup.34-(Aspa-AOct)-GLP-1(7-39);
Arg.sup.34Lys.sup.26-(Aspa-AOct)-GLP-1(7-39);
Arg.sup.26,34Lys.sup.39-(Aspa-AOct)-GLP-1(7-39);
[0873] Gly.sup.8Arg.sup.26Lys.sup.34-(Aspa-AOct)-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.26-(Aspa-AOct)-GLP-1(7-36);
Gly.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.34-(Aspa-AOct)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.34Lys.sup.26-(Aspa-AOct)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26Lys.sup.34-(Aspa-AOct)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26-(Aspa-AOct)-GLP-1(7-37);
Gly.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34-(Aspa-AOct)-GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.26-(Aspa-AOct)-GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.38-(Aspa-AOct)-GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.34-(Aspa-AOct)-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.26-(Aspa-AOct)-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.39-(Aspa-AOct)-GLP-1(7-39);
[0874] Val.sup.8Arg.sup.26Lys.sup.34-(Aspa-AOct)-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.26-(Aspa-AOct)-GLP-1(7-36);
Val.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.34-(Aspa-AOct)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.34Lys.sup.26-(Aspa-AOct)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26Lys.sup.34-(Aspa-AOct)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26-(Aspa-AOct)-GLP-1(7-37);
Val.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34(Aspa-AOct)-GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.26-(Aspa-AOct)-GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.38-(Aspa-AOct)-GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.34-(Aspa-AOct)-GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.26-(Aspa-AOct)-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.39-(Aspa-AOct)-GLP-1(7-39);
[0875] Ser.sup.8Arg.sup.26Lys.sup.34-(Aspa-AOct)-GLP-1(7-36);
Ser.sup.8Arg.sup.34Lys.sup.26-(Aspa-AOct)-GLP-1(7-36);
Ser.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-36);
Ser.sup.8Arg.sup.26Lys.sup.34-(Aspa-AOct)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.34Lys.sup.26-(Aspa-AOct)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26,34 Lys.sup.36-(Aspa-AOct)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26Lys.sup.34-(Aspa-AOct)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26-(Aspa-AOct)-GLP-1(7-37);
Ser.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34-(Aspa-AOct)-GLP-1(7-38);
Ser.sup.8Arg.sup.34Lys.sup.26-(Aspa-AOct)-GLP-1(7-38);
Ser.sup.8Arg.sup.26,34Lys.sup.38-(Aspa-AOct)-GLP-1(7-38);
Ser.sup.8Arg.sup.26Lys.sup.34-(Aspa-AOct)-GLP-1(7-39);
Ser.sup.8Arg.sup.34Lys.sup.26-(Aspa-AOct)-GLP-1(7-39);
Ser.sup.8Arg.sup.26,34Lys.sup.39-(Aspa-AOct)-GLP-1(7-39);
[0876] Thr.sup.8Arg.sup.26Lys.sup.34-(Aspa-AOct)-GLP-1(7-36);
Thr.sup.8Arg.sup.34Lys.sup.26-(Aspa-AOct)-GLP-1(7-36);
Thr.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-36);
Thr.sup.8Arg.sup.26Lys.sup.34-(Aspa-AOct)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.34Lys.sup.26-(Aspa-AOct)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26Lys.sup.34-(Aspa-AOct)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26-(Aspa-AOct)-GLP-1(7-37);
Thr.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34-(Aspa-AOct)-GLP-1(7-38);
Thr.sup.8Arg.sup.34Lys.sup.26-(Aspa-AOct)-GLP-1(7-38);
Thr.sup.8Arg.sup.26,34Lys.sup.38-(Aspa-AOct)-GLP-1(7-38);
Thr.sup.8Arg.sup.26Lys.sup.34-(Aspa-AOct)-GLP-1(7-39);
Thr.sup.8Arg.sup.34Lys.sup.26-(Aspa-AOct)-GLP-1(7-39);
Thr.sup.8Arg.sup.26,34Lys.sup.39-(Aspa-AOct)-GLP-1(7-39);
[0877]
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-36)-
;
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-AOct)-GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-AOct)-GLP-1(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-AOct)-GLP-1(7-39);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-36);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-AOct)-GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-AOct)-GLP-1(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-AOct)-GLP-1(7-39);
[0878]
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-36)-
;
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-AOct)-GLP-1(7-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-AOct)-GLP-1(7-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-AOct)-GLP-1(7-39);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-36);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-AOct)-GLP-1(7-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-AOct)-GLP-1(7-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-AOct)-GLP-1(7-39);
[0879]
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-36)-
;
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-AOct)-GLP-1(7-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-AOct)-GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-AOct)-GLP-1(7-39);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-36);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-AOct)-GLP-1(7-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-AOct)-GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-AOct)-GLP-1(7-39);
[0880]
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-36)-
;
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-AOct)-GLP-1(7-37);
Val.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-AOct)-GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-AOct)-GLP-1(7-39);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-36);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-AOct)-GLP-1(7-37);
Val.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-AOct)-GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-AOct)-GLP-1(7-39);
[0881]
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-36)-
;
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-AOct)-GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-AOct)-GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-AOct)-GLP-1(7-39);
Ser.sup.8Glu.sup.35Arg.sup.26,34
Lys.sup.36-(Aspa-AOct)-GLP-1(7-36);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-AOct)-GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-AOct)-GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-AOct)-GLP-1(7-39);
[0882]
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-36)-
;
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34
Lys.sup.37-(Aspa-AOct)-GLP-1(7-37);
Ser.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-AOct)-GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-AOct)-GLP-1(7-39);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-36);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-AOct)-GLP-1(7-37);
Ser.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-AOct)-GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-AOct)-GLP-1(7-39);
[0883]
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-36)-
;
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-AOct)-GLP-1(7-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-AOct)-GLP-1(7-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-AOct)-GLP-1(7-39);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-36);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-AOct)-GLP-1(7-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.3-(Aspa-AOct)-GLP-1(7-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-AOct)-GLP-1(7-39);
[0884]
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-36)-
;
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-AOct)-GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-AOct)-GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-AOct)-GLP-1(7-39);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-AOct)-GLP-1(7-36);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36(Aspa-AOct)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-AOct)-GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-AOct)-GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-AOct)-GLP-1(7-39);
[0885] Arg.sup.26,34Lys.sup.18-(Aspa-AOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Aspa-AOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Aspa-AOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Aspa-AOct)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-AOct)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-AOct)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-AOct)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-AOct)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18(Aspa-AOct)-GLP-(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-AOct)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-AOct)-GLP-1(7-38);
[0886] Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-38);
[0887] Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-38);
[0888] Arg.sup.26,34Lys.sup.18-(Aspa-AOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Aspa-AOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18(Aspa-AOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Aspa-AOct)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-AOct)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-AOct)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-AOct)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-AOct)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-AOct)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-AOct)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-AOct)-GLP-1(7-38);
[0889] Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-38);
[0890] Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-38);
[0891] Arg.sup.26,34Lys.sup.18-(Aspa-AOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Aspa-AOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Aspa-AOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18(Aspa-AOct)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-AOct)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-AOct)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-AOct)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-AOct)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-AOct)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-AOct)-GLP-1(7-38);
Ser.sup.8Asp.sup.7Arg.sup.26,34Lys.sup.18-(Aspa-AOct)-GLP-1(7-38);
[0892] Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-38);
[0893] Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-38);
[0894] Arg.sup.26,34Lys.sup.18-(Aspa-AOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Aspa-AOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Aspa-AOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Aspa-AOct)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-AOct)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-AOct)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-AOct)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-AOct)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-AOct)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-AOct)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-AOct)-GLP-1(7-38);
[0895] Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-AOct)-GLP-1(7-38);
[0896] Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-AOct)-GLP-1(7-38);
[0897] Arg.sup.26Lys.sup.34-(Aspa-ALit)-GLP-1(7-36);
Arg.sup.34Lys.sup.26-(Aspa-ALit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-36);
Arg.sup.26Lys.sup.34-(Aspa-ALit)-GLP-1(7-36)amide;
Arg.sup.34Lys.sup.26-GLP-ALit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-36)amide;
Arg.sup.26Lys.sup.34(Aspa-ALit)-GLP-1(7-37);
Arg.sup.34Lys.sup.26-(Aspa-ALit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-37);
Arg.sup.26Lys.sup.34-(Aspa-ALit)-GLP-1(7-38);
Arg.sup.34Lys.sup.26-(Aspa-ALit)-GLP-1(7-38);
Arg.sup.26,34Lys.sup.38-(Aspa-ALit)-GLP-1(7-38);
Arg.sup.26Lys.sup.34-(Aspa-ALit)-GLP-1(7-39);
Arg.sup.34Lys.sup.26-(Aspa-ALit)-GLP-1(7-39);
Arg.sup.26,34Lys.sup.39-(Aspa-ALit)-GLP-1(7-39);
[0898] Gly.sup.8Arg.sup.26Lys.sup.34-(Aspa-ALit)-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.26-(Aspa-ALit)-GLP-1(7-36);
Gly.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.34-(Aspa-ALit)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.34Lys.sup.26-(Aspa-ALit)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26Lys.sup.34-(Aspa-ALit)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26-(Aspa-ALit)-GLP-1(7-37);
Gly.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34-(Aspa-ALit)-GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.26-(Aspa-ALit)-GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.38-(Aspa-ALit)-GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.34-(Aspa-ALit)-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.26-(Aspa-ALit)-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.39-(Aspa-ALit)-GLP-1(7-39);
[0899] Val.sup.8Arg.sup.26Lys.sup.34-(Aspa-ALit)-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.26-(Aspa-ALit)-GLP-1(7-36);
Val.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.34-(Aspa-ALit)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.34Lys.sup.26-(Aspa-ALit)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26Lys.sup.34-(Aspa-ALit)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26-(Aspa-ALit)-GLP-1(7-37);
Val.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34-(Aspa-ALit)-GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.26-(Aspa-ALit)-GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.38-(Aspa-ALit)-GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.34-(Aspa-ALit)-GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.26-(Aspa-ALit)-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.39-(Aspa-ALit)-GLP-1(7-39);
[0900] Ser.sup.8Arg.sup.26Lys.sup.34-(Aspa-ALit)-GLP-1(7-36);
Ser.sup.8Arg.sup.34Lys.sup.26-(Aspa-ALit)-GLP-1(7-36);
Ser.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-36);
Ser.sup.8Arg.sup.26Lys.sup.34-(Aspa-ALit)-GLP-1(7-36)amide
Ser.sup.8Arg.sup.34Lys.sup.26-(Aspa-ALit)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26Lys.sup.34-(Aspa-ALit)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26-(Aspa-ALit)-GLP-1(7-37);
Ser.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34-(Aspa-ALit)-GLP-1(7-38);
Ser.sup.8Arg.sup.34Lys.sup.26-(Aspa-ALit)-GLP-1(7-38);
Ser.sup.8Arg.sup.26,34Lys.sup.38-(Aspa-ALit)-GLP-1(7-38);
Ser.sup.8Arg.sup.26Lys.sup.34-(Aspa-ALit)-GLP-1(7-39);
Ser.sup.8Arg.sup.34Lys.sup.26-(Aspa-ALit)-GLP-1(7-39);
Ser.sup.8Arg.sup.26,34Lys.sup.39-(Aspa-ALit)-GLP-1(7-39);
[0901] Thr.sup.8Arg.sup.26Lys.sup.34-(Aspa-ALit)-GLP-1(7-36);
Thr.sup.8Arg.sup.34Lys.sup.26-(Aspa-ALit)-GLP-1(7-36);
Thr.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-36);
Thr.sup.8Arg.sup.26Lys.sup.34-(Aspa-ALit)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.34Lys.sup.26-(Aspa-ALit)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.26Lys.sup.34-(Aspa-ALit)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26-(Aspa-ALit)-GLP-1(7-37);
Thr.sup.8Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34-(Aspa-ALit)-GLP-1(7-38);
Thr.sup.8Arg.sup.34Lys.sup.26-(Aspa-ALit)-GLP-1(7-38);
Thr.sup.8Arg.sup.26,34Lys.sup.38-(Aspa-ALit)-GLP-1(7-38);
Thr.sup.8Arg.sup.26Lys.sup.34-(Aspa-ALit)-GLP-1(7-39);
Thr.sup.8Arg.sup.34Lys.sup.26-(Aspa-ALit)-GLP-1(7-39);
Thr.sup.8Arg.sup.26,34Lys.sup.39-(Aspa-ALit)-GLP-1(7-39);
[0902]
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-36)-
;
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ALit)-GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ALit)-GLP-1(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ALit)-GLP-1(7-39);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-36);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ALit)-GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ALit)-GLP-1(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ALit)-GLP-1(7-39);
[0903]
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-36)-
;
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ALit)-GLP-1(7-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ALit)-GLP-1(7-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ALit)-GLP-1(7-39);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-36);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ALit)-GLP-1(7-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ALit)-GLP-1(7-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ALit)-GLP-1(7-39);
[0904]
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-36)-
;
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ALit)-GLP-1(7-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ALit)-GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ALit)-GLP-1(7-39);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-36);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ALit)-GLP-1(7-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ALit)-GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ALit)-GLP-1(7-39);
[0905]
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-36)-
;
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ALit)-GLP-1(7-37);
Val.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ALit)-GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ALit)-GLP-1(7-39);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-36);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ALit)-GLP-1(7-37);
Val.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ALit)-GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ALit)-GLP-1(7-39);
[0906]
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-36)-
;
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ALit)-GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ALit)-GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ALit)-GLP-1(7-39);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-36);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ALit)-GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ALit)-GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ALit)-GLP-1(7-39);
[0907]
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-36)-
;
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ALit)-GLP-1(7-37);
Ser.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ALit)-GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ALit)-GLP-1(7-39);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-36);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ALit)-GLP-1(7-37);
Ser.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ALit)-GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ALit)-GLP-1(7-39);
[0908]
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-36)-
;
Thr.sup.8(Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-36)amide-
;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ALit)-GLP-1(7-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ALit)-GLP-1(7-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ALit)-GLP-1(7-39);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-36);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ALit)-GLP-1(7-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ALit)-GLP-1(7-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ALit)-GLP-1(7-39);
[0909]
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-36)-
;
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ALit)-GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ALit)-GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ALit)-GLP-1(7-39);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-36);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Aspa-ALit)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Aspa-ALit)-GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Aspa-ALit)-GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Aspa-ALit)-GLP-1(7-39);
[0910] Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-38);
[0911] Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-38);
[0912] Arg.sup.26,34Lys.sup.27-(Aspa-ALit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Aspa-ALit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Aspa-ALit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Aspa-ALit)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ALit)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-ALit)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ALit)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-ALit)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ALit)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ALit)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-ALit)-GLP-1(7-38);
[0913] Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-38);
[0914] Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-38);
[0915] Arg.sup.26,34Lys.sup.27-(Aspa-ALit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Aspa-ALit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Aspa-ALit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Aspa-ALit)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ALit)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-ALit)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ALit)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.37-(Aspa-ALit)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ALit)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ALit)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-ALit)-GLP-1(7-38);
[0916] Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-38);
[0917] Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-38);
[0918] Arg.sup.26,34Lys.sup.27-(Aspa-ALit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Aspa-ALit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Aspa-ALit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27(Aspa-ALit)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ALit)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-ALit)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ALit)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-ALit)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ALit)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ALit)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-ALit)-GLP-1(7-38);
[0919] Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Aspa-ALit)-GLP-1(7-38);
[0920] Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34
Lys.sup.23-(Aspa-ALit)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Aspa-ALit)-GLP-1(7-38);
[0921] Arg.sup.26,34Lys.sup.27-(Aspa-ALit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Aspa-ALit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Aspa-ALit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Aspa-ALit)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ALit)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34
Lys.sup.27-(Aspa-ALit)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ALit)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-ALit)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ALit)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Aspa-ALit)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Aspa-ALit)-GLP-1(7-38);
[0922] Arg.sup.26Lys.sup.34-(Glyc-ADod)-GLP-1(7-36);
Arg.sup.34Lys.sup.26-(Glyc-ADod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-36);
Arg.sup.26Lys.sup.34-(Glyc-ADod)-GLP-1(7-36)amide;
Arg.sup.34Lys.sup.26(Glyc-ADod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-36)amide;
Arg.sup.26Lys.sup.34-(Glyc-ADod)-GLP-1(7-37);
Arg.sup.34Lys.sup.26-(Glyc-ADod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-37);
Arg.sup.26Lys.sup.34-(Glyc-ADod)-GLP-1(7-38);
Arg.sup.34Lys.sup.26-(Glyc-ADod)-GLP-1(7-38);
Arg.sup.26,34Lys.sup.38-(Glyc-ADod)-GLP-1(7-38);
Arg.sup.26Lys.sup.34-(Glyc-ADod)-GLP-1(7-39);
Arg.sup.34Lys.sup.26-(Glyc-ADod)-GLP-1(7-39);
Arg.sup.26,34Lys.sup.39(Glyc-ADod)-GLP-1(7-39);
[0923] Gly.sup.8Arg.sup.26Lys.sup.34(Glyc-ADod)-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.26(Glyc-ADod)-GLP-1(7-36);
Gly.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.34(Glyc-ADod)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.34Lys.sup.26-(Glyc-ADod)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26Lys.sup.34-(Glyc-ADod)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26-(Glyc-ADod)-GLP-1(7-37);
Gly.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34-(Glyc-ADod)-GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.26-(Glyc-ADod)-GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.38-(Glyc-ADod)-GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.34-(Glyc-ADod)-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.26-(Glyc-ADod)-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.39-(Glyc-ADod)-GLP-1(7-39);
[0924] Val.sup.8Arg.sup.26Lys.sup.34-(Glyc-ADod)-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.26-(Glyc-ADod)-GLP-1(7-36);
Val.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.34-(Glyc-ADod)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.34Lys.sup.26-(Glyc-ADod)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26Lys.sup.34-(Glyc-ADod)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26-(Glyc-ADod)-GLP-1(7-37);
Val.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34-(Glyc-ADod)-GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.26-(Glyc-ADod)-GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.38-(Glyc-ADod)-GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.34-(Glyc-ADod)-GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.26-(Glyc-ADod)-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.39-(Glyc-ADod)-GLP-1(7-39);
[0925] Ser.sup.8Arg.sup.26Lys.sup.34-(Glyc-ADod)-GLP-1(7-36);
Ser.sup.8Arg.sup.34Lys.sup.26-(Glyc-ADod)-GLP-1(7-36);
Ser.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-36);
Ser.sup.8Arg.sup.26Lys.sup.34-(Glyc-ADod)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.34Lys.sup.26-(Glyc-ADod)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26Lys.sup.34-(Glyc-ADod)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26-(Glyc-ADod)-GLP-1(7-37);
Ser.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34-(Glyc-ADod)-GLP-1(7-38);
Ser.sup.8Arg.sup.34Lys.sup.26-(Glyc-ADod)-GLP-1(7-38);
Ser.sup.8Arg.sup.26,34Lys.sup.38-(Glyc-ADod)-GLP-1(7-38);
Ser.sup.8Arg.sup.26Lys.sup.34-(Glyc-ADod)-GLP-1(7-39);
Ser.sup.8Arg.sup.34Lys.sup.26-(Glyc-ADod)-GLP-1(7-39);
Ser.sup.8Arg.sup.26,34Lys.sup.39-(Glyc-ADod)-GLP-1(7-39);
[0926] Thr.sup.8Arg.sup.26Lys.sup.34-(Glyc-ADod)-GLP-1(7-36);
Thr.sup.8Arg.sup.34Lys.sup.26-(Glyc-ADod)-GLP-1(7-36);
Thr.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-36);
Thr.sup.8Arg.sup.26Lys.sup.34-(Glyc-ADod)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.34Lys.sup.26-(Glyc-ADod)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.26,34Lys.sup.36(Glyc-ADod)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.26Lys.sup.34-(Glyc-ADod)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26-(Glyc-ADod)-GLP-1(7-37);
Thr.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34-(Glyc-ADod)-GLP-1(7-38);
Thr.sup.8Arg.sup.34Lys.sup.26-(Glyc-ADod)-GLP-1(7-38);
Thr.sup.8Arg.sup.26,34Lys.sup.38-(Glyc-ADod)-GLP-1(7-38);
Thr.sup.8Arg.sup.26Lys.sup.34-(Glyc-ADod)-GLP-1(7-39);
Thr.sup.8Arg.sup.34Lys.sup.26(Glyc-ADod)-GLP-1(7-39);
Thr.sup.8Arg.sup.26,34Lys.sup.39-(Glyc-ADod)-GLP-1(7-39);
[0927]
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36(Glyc-ADod)-GLP-1(7-36);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ADod)-GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ADod)-GLP-1(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ADod)-GLP-1(7-39);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-36);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ADod)-GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ADod)-GLP-1(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ADod)-GLP-1(7-39);
[0928]
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-36)-
;
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ADod)-GLP-1(7-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ADod)-GLP-1(7-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ADod)-GLP-1(7-39);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-36);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ADod)-GLP-1(7-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ADod)-GLP-1(7-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ADod)-GLP-1(7-39);
[0929]
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-36)-
;
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ADod)-GLP-1(7-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ADod)-GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ADod)-GLP-1(7-39);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-36);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ADod)-GLP-1(7-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ADod)-GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ADod)-GLP-1(7-39);
[0930]
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-36)-
;
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ADod)-GLP-1(7-37);
Val.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ADod)-GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ADod)-GLP-1(7-39);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-36);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ADod)-GLP-1(7-37);
Val.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ADod)-GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ADod)-GLP-1(7-39);
[0931]
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-36)-
;
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ADod)-GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ADod)-GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ADod)-GLP-1(7-39);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-36);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ADod)-GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ADod)-GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ADod)-GLP-1(7-39);
[0932]
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-36)-
;
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ADod)-GLP-1(7-37);
Ser.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ADod)-GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ADod)-GLP-1(7-39);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-36);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ADod)-GLP-1(7-37);
Ser.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ADod)-GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ADod)-GLP-1(7-39);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-36);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ADod)-GLP-1(7-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ADod)-GLP-1(7-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ADod)-GLP-1(7-39);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-36);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ADod)-GLP-1(7-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ADod)-GLP-1(7-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ADod)-GLP-1(7-39);
[0933]
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-36)-
;
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ADod)-GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ADod)-GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ADod)-GLP-1(7-39);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-36);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ADod)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ADod)-GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ADod)-GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ADod)-GLP-1(7-39);
[0934] Arg.sup.26,34Lys.sup.18-(Glyc-ADod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Glyc-ADod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Glyc-ADod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Glyc-ADod)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ADod)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-ADod)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ADod)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-ADod)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ADod)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ADod)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-ADod)-GLP-1(7-38);
[0935] Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-38);
[0936] Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-38);
[0937] Arg.sup.26,34Lys.sup.18-(Glyc-ADod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Glyc-ADod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Glyc-ADod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Glyc-ADod)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ADod)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-ADod)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ADod)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-ADod)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ADod)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ADod)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-ADod)-GLP-1(7-38);
[0938] Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-38);
[0939] Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-38);
[0940] Arg.sup.26,34Lys.sup.18(Glyc-ADod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Glyc-ADod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Glyc-ADod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Glyc-ADod)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ADod)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-ADod)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ADod)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-ADod)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ADod)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ADod)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-ADod)-GLP-1(7-38);
[0941] Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-38);
[0942] Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-38);
[0943] Arg.sup.26,34Lys.sup.18(Glyc-ADod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Glyc-ADod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Glyc-ADod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Glyc-ADod)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ADod)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-ADod)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-((Glyc-ADod)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-ADod)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ADod)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ADod)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-ADod)-GLP-1(7-38);
[0944] Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-ADod)-GLP-1(7-38);
[0945] Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-ADod)-GLP-1(7-38);
[0946] Arg.sup.26Lys.sup.34-(Glyc-ATet)-GLP-1(7-36);
Arg.sup.34Lys.sup.26-(Glyc-ATet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-36);
Arg.sup.26Lys.sup.34-(Glyc-ATet)-GLP-1(7-36)amide;
Arg.sup.34Lys.sup.26-(Glyc-ATet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-36)amide;
Arg.sup.26Lys.sup.34-(Glyc-ATet)-GLP-1(7-37);
Arg.sup.34Lys.sup.26-(Glyc-ATet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-37);
Arg.sup.26Lys.sup.34-(Glyc-ATet)-GLP-1(7-38);
Arg.sup.34Lys.sup.26-(Glyc-ATet)-GLP-1(7-38);
Arg.sup.26,34Lys.sup.38-(Glyc-ATet)-GLP-1(7-38);
Arg.sup.26Lys.sup.34-(Glyc-ATet)-GLP-1(7-39);
Arg.sup.34Lys.sup.26-(Glyc-ATet)-GLP-1(7-39);
Arg.sup.26,34Lys.sup.39-(Glyc-ATet)-GLP-1(7-39);
[0947] Gly.sup.8Arg.sup.26Lys.sup.34-(Glyc-ATet)-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.26-(Glyc-ATet)-GLP-1(7-36);
Gly.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.34-(Glyc-ATet)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.34Lys.sup.26-(Glyc-ATet)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26Lys.sup.34-(Glyc-ATet)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26-(Glyc-ATet)-GLP-1(7-37);
Gly.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34-(Glyc-ATet)-GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.26-(Glyc-ATet)-GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.38-(Glyc-ATet)-GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.34-(Glyc-ATet)-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.26-(Glyc-ATet)-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.39-(Glyc-ATet)-GLP-1(7-39);
[0948] Val.sup.8Arg.sup.26Lys.sup.34-(Glyc-ATet)-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.26-(Glyc-ATet)-GLP-1(7-36);
Val.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.34-(Glyc-ATet)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.34Lys.sup.26-(Glyc-ATet)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26Lys.sup.34-(Glyc-ATet)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26-(Glyc-ATet)-GLP-1(7-37);
Val.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34(Glyc-ATet)-GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.26-(Glyc-ATet)-GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.38-(Glyc-ATet)-GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.34-(Glyc-ATet)-GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.26-(Glyc-ATet)-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.39-(Glyc-ATet)-GLP-1(7-39);
[0949] Ser.sup.8Arg.sup.26Lys.sup.34-(Glyc-ATet)-GLP-1(7-36);
Ser.sup.8Arg.sup.34Lys.sup.26-(Glyc-ATet)-GLP-1(7-36);
Ser.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-36);
Ser.sup.8Arg.sup.26Lys.sup.34-(Glyc-ATet)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.34Lys.sup.26-(Glyc-ATet)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26Lys.sup.34-(Glyc-ATet)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26-(Glyc-ATet)-GLP-1(7-37);
Ser.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34-(Glyc-ATet)-GLP-1(7-38);
Ser.sup.8Arg.sup.14Lys.sup.26-(Glyc-ATet)-GLP-1(7-38);
Ser.sup.8Arg.sup.26,34Lys.sup.38-(Glyc-ATet)-GL-1-(7-38);
Ser.sup.8Arg.sup.26Lys.sup.34-(Glyc-ATet)-GLP-1(7-39);
Ser.sup.8Arg.sup.34Lys.sup.26-(Glyc-ATet)-GLP-1(7-39);
Ser.sup.8Arg.sup.26,34Lys.sup.39-(Glyc-ATet)-GLP-1(7-39);
[0950] Thr.sup.8Arg.sup.26Lys.sup.34-(Glyc-ATet)-GLP-1(7-36);
Thr.sup.8Arg.sup.34Lys.sup.26-(Glyc-ATet)-GLP-1(7-36);
Thr.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-36);
Thr.sup.8Arg.sup.26Lys.sup.34-(Glyc-ATet)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.34Lys.sup.26-(Glyc-ATet)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.26Lys.sup.34(Glyc-ATet)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26-(Glyc-ATet)-GLP-1(7-37);
Thr.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34(Glyc-ATet)-GLP-1(7-38);
Thr.sup.8Arg.sup.34Lys.sup.26-(Glyc-ATet)-GLP-1(7-38); The
Arg.sup.26,34Lys.sup.38-(Glyc-ATet)-GLP-1(7-38);
Thr.sup.8Arg.sup.26Lys.sup.34-(Glyc-ATet)-GLP-1(7-39);
Thr.sup.8Arg.sup.34Lys.sup.26(Glyc-ATet)-GLP-1(7-39);
Thr.sup.8Arg.sup.26,34Lys.sup.39-(Glyc-ATet)-GLP-1(7-39);
[0951]
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-36)-
;
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ATet)-GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ATet)-GLP-1(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ATet)-GLP-1(7-39);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-36);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ATet)-GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ATet)-GLP-1(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ATet)-GLP-1(7-39);
[0952]
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-36)-
;
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ATet)-GLP-1(7-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ATet)-GLP-1(7-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ATet)-GLP-1(7-39);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-36);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ATet)-GLP-1(7-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ATet)-GLP-1(7-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ATet)-GLP-1(7-39);
[0953]
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-36)-
;
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ATet)-GLP-1(7-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ATet)-GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ATet)-GLP-1(7-39);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-36);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ATet)-GLP-1(7-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ATet)-GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ATet)-GLP-1(7-39);
[0954]
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-36)-
;
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ATet)-GLP-1(7-37);
Val.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ATet)-GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ATet)-GLP-1(7-39);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-36);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ATet)-GLP-1(7-37);
Val.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ATet)-GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39(Glyc-ATet)-GLP-1(7-39);
[0955]
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-36)-
;
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ATet)-GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ATet)-GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ATet)-GLP-1(7-39);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-36);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ATet)-GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ATet)-GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ATet)-GLP-1(7-39);
[0956]
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-36)-
;
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ATet)-GLP-1(7-37);
Ser.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ATet)-GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ATet)-GLP-1(7-39);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-36);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ATet)-GLP-1(7-37);
Ser.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ATet)-GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ATet)-GLP-1(7-39);
[0957]
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-36)-
;
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ATet)-GLP-1(7-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ATet)-GLP-1(7-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ATet)-GLP-1(7-39);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-36);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ATet)-GLP-1(7-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ATet)-GLP-1(7-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ATet)-GLP-1(7-39);
[0958]
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-36)-
;
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ATet)-GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ATet)-GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ATet)-GLP-1(7-39);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-36);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ATet)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ATet)-GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ATet)-GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ATet)-GLP-1(7-39);
[0959] Arg.sup.26,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-38);
[0960] Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-37);
Gly.sup.8Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-38);
[0961] Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-38);
[0962] Arg.sup.26,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-38);
[0963] Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-38);
[0964] Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-38);
[0965] Arg.sup.26,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-38);
[0966] Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-38);
[0967] Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-38);
[0968] Arg.sup.26,34Lys.sup.18(Glyc-ATet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.23,34Lys.sup.18-(Glyc-ATet)-GLP-1(7-38);
[0969] Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-38);
Th.sup.8Asp.sup.19Arg26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-21(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-ATet)-GLP-1(7-38);
[0970] Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-ATet)-GLP-1(7-38);
[0971] Arg.sup.26Lys.sup.34-(Glyc-AHex)-GLP-1(7-36);
Arg.sup.34Lys.sup.26(Glyc-AHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-36);
Arg.sup.26Lys.sup.34-(Glyc-AHex)-GLP-1(7-36)amide;
Arg.sup.34Lys.sup.26-(Glyc-AHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-36)amide;
Arg.sup.26Lys.sup.34(Glyc-AHex)-GLP-1(7-37);
Arg.sup.34Lys.sup.26-(Glyc-AHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-37);
Arg.sup.26Lys.sup.34(Glyc-AHex)-GLP-1(7-38);
Arg.sup.34Lys.sup.26-(Glyc-AHex)-GLP-1(7-38);
Arg.sup.26,34Lys.sup.38-(Glyc-AHex)-GLP-1(7-38);
Arg.sup.26Lys.sup.34-(Glyc-AHex)-GLP-1(7-39);
Arg.sup.34Lys.sup.26-(Glyc-AHex).sup.-GLP-1(7-39);
Arg.sup.26,34Lys.sup.39-(Glyc-AHex)-GLP-1(7-39);
[0972] Gly.sup.8Arg.sup.26Lys.sup.34-(Glyc-AHex)-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.26-(Glyc-AHex)-GLP-1(7-36);
Gly.sup.8Arg.sup.26,34Lys.sup.36(Glyc-AHex)-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.34-(Glyc-AHex)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.34Lys.sup.26-(Glyc-AHex)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26Lys.sup.34-(Glyc-AHex)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26-(Glyc-AHex)-GLP-1(7-37);
Gly.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34-(Glyc-AHex)-GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.26-(Glyc-AHex)-GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.38-(Glyc-AHex)-GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.34-(Glyc-AHex)-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.26-(Glyc-AHex)-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.39-(Glyc-AHex)-GLP-1(7-39);
[0973] Val.sup.8Arg.sup.26Lys.sup.34-(Glyc-AHex)-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.26-(Glyc-AHex)-GLP-1(7-36);
Val.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.34-(Glyc-AHex)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.34Lys.sup.26-(Glyc-AHex)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26Lys.sup.34-(Glyc-AHex)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26-(Glyc-AHex)-GLP-1(7-37);
Val.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34-(Glyc-AHex)-GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.26-(Glyc-AHex)-GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.38-(Glyc-AHex)-GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.34-(Glyc-AHex)-GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.26-(Glyc-AHex)-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.39-(Glyc-AHex)-GLP-1(7-39);
[0974] Ser.sup.8Arg.sup.26Lys.sup.34-(Glyc-AHex)-GLP-1(7-36);
Ser.sup.8Arg.sup.34Lys.sup.26-(Glyc-AHex)-GLP-1(7-36);
Ser.sup.8Arg.sup.26,34 Lys.sup.36-(Glyc-AHex)-GLP-1(7-36);
Ser.sup.8Arg.sup.26Lys.sup.34-(Glyc-AHex)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.34Lys.sup.26-(Glyc-AHex)-GLP-1(7-36);
Ser.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-AHex-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26Lys.sup.34-(Glyc-AHex)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26-(Glyc-AHex)-GLP-1(7-37);
Ser.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34-(Glyc-AHex)-GLP-1(7-38);
Ser.sup.8Arg.sup.34Lys.sup.26-(Glyc-AHex)-GLP-1(7-38);
Ser.sup.8Arg.sup.26,34Lys.sup.38-(Glyc-AHex)-GLP-1(7-38);
Ser.sup.8Arg.sup.26Lys.sup.34-(Glyc-AHex)-GLP-1(7-39);
Ser.sup.8Arg.sup.34Lys.sup.26-(Glyc-AHex)-GLP-1(7-39);
Ser.sup.8Arg.sup.26,34Lys.sup.39-(Glyc-AHex)-GLP-1(7-39);
[0975] Thr.sup.8Arg.sup.26Lys.sup.34-(Glyc-AHex)-GLP-1(7-36);
Thr.sup.8Arg.sup.34Lys.sup.26-(Glyc-AHex)-GLP-1(7-36);
Thr.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-36);
Thr.sup.8Arg.sup.26Lys.sup.34-(Glyc-AHex)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.34Lys.sup.26-(Glyc-AHex)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.26,34 Lys.sup.36-(Glyc-AHex)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.26Lys.sup.34-(Glyc-AHex)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26-(Glyc-AHex)-GLP-1(7-37);
Thr.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34-(Glyc-AHex)-GLP-1(7-38);
Thr.sup.8Arg.sup.34Lys.sup.26-(Glyc-AHex)-GLP-1(7-38);
Thr.sup.8Arg.sup.26,34Lys.sup.38-(Glyc-AHex)-GLP-1(7-38);
Thr.sup.8Arg.sup.26Lys.sup.34-(Glyc-AHex)-GLP-1(7-39);
Thr.sup.8Arg.sup.34Lys.sup.26-(Glyc-AHex)-GLP-1(7-39);
Thr.sup.8Arg.sup.26,34Lys.sup.39-(Glyc-AHex)-GLP-1(7-39);
[0976]
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-36)-
;
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-AHex)-GLP-1(7-37);
Gly.sup.8Glu.sup.37(Arg.sup.26,34Lys.sup.38-(Glyc-AHex)-GLP-1(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-AHex)-GLP-1(7-39);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-36);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-AHex)-GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-AHex)-GLP-1(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-AHex)-GLP-1(7-39);
[0977]
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-36)-
;
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-AHex)-GLP-1(7-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-AHex)-GLP-1(7-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-AHex)-GLP-1(7-39);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-36);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-AHex)-GLP-1(7-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-AHex)-GLP-1(7-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-AHex)-GLP-1(7-39);
[0978]
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-36)-
;
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-AHex)-GLP-1(7-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-AHex)-GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-AHex)-GLP-1(7-39);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-36);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-AHex)-GLP-1(7-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-AHex)-GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-AHex)-GLP-1(7-39);
[0979]
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-36)-
;
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-AHex)-GLP-1(7-37);
Val.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-AHex)-GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-AHex)-GLP-1(7-39);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-36);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-AHex)-GLP-1(7-37);
Val.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-AHex)-GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-AHex)-GLP-1(7-39);
[0980]
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-36)-
;
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-AHex)-GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-AHex)-GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-AHex)-GLP-1(7-39);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-36);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-AHex)-GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-AHex)-GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-AHex)-GLP-1(7-39);
[0981]
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-36)-
;
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-AHex)-GLP-1(7-37);
Ser.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-AHex)-GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-AHex)-GLP-1(7-39);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-36);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-AHex)-GLP-1(7-37);
Ser.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-AHex)-GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-AHex)-GLP-1(7-39);
[0982]
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-36)-
;
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-AHex)-GLP-1(7-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-AHex)-GLP-1(7-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-AHex)-GLP-1(7-39);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-36);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-AHex)-GLP-1(7-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-AHex)-GLP-1(7-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-AHex)-GLP-1(7-39);
[0983]
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-36)-
;
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-AHex)-GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-AHex)-GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-AHex)-GLP-1(7-39);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-36);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AHex)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-AHex)-GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-AHex)-GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-AHex)-GLP-1(7-39);
[0984] Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-38);
[0985] Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-38);
[0986] Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-38);
[0987] Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-36)amide;
Val.sup.8-Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-38);
[0988] Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-38);
[0989] Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-38);
[0990] Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-38);
[0991] Arg.sup.26,34Lys.sup.23(Glyc-AHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-37);
Ser.sup.8Asp19Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-38);
[0992] Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-38);
[0993] Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-37);
Th.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-AHex)-GLP-1(7-38);
[0994] Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-AHex)-GLP-1(7-38);
[0995] Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-AHex)-GLP-1(7-38);
[0996] Arg.sup.26Lys.sup.34-(Glyc-AOct)-GLP-1(7-36);
Arg.sup.34Lys.sup.26-(Glyc-AOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-36);
Arg.sup.26Lys.sup.34-(Glyc-AOct)-GLP-1(7-36)amide;
Arg.sup.34Lys.sup.26-(Glyc-AOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-36)amide;
Arg.sup.26Lys.sup.34-(Glyc-AOct)-GLP-1(7-37);
Arg.sup.34Lys.sup.26-(Glyc-AOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-37);
Arg.sup.26Lys.sup.34-(Glyc-AOct)-GLP-1(7-38);
Arg.sup.34Lys.sup.26-(Glyc-AOct)-GLP-1(7-38);
Arg.sup.26,34Lys.sup.38-(Glyc-AOct)-GLP-1(7-38);
Arg.sup.26Lys.sup.34-(Glyc-AOct)-GLP-1(7-39);
Arg.sup.34Lys.sup.26-(Glyc-AOct)-GLP-1(7-39);
Arg.sup.26,34Lys.sup.39-(Glyc-AOct)-GLP-1(7-39);
[0997] Gly.sup.8Arg.sup.26Lys.sup.34-(Glyc-AOct)-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.26-(Glyc-AOct)-GLP-1(7-36);
Gly.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.34-(Glyc-AOct)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.34Lys.sup.26-(Glyc-AOct)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26Lys.sup.34-(Glyc-AOct)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26-(Glyc-AOct)-GLP-1(7-37);
Gly.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34-(Glyc-AOct)-GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.26-(Glyc-AOct)-GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.38-(Glyc-AOct)-GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.34-(Glyc-AOct)-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.26-(Glyc-AOct)-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.39-(Glyc-AOct)-GLP-1(7-39);
[0998] Val.sup.8Arg.sup.26Lys.sup.34-(Glyc-AOct)-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.26-(Glyc-AOct)-GLP-1(7-36);
Val.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.34-(Glyc-AOct)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.34Lys.sup.26-(Glyc-AOct)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26Lys.sup.34-(Glyc-AOct)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26-(Glyc-AOct)-GLP-1(7-37);
Val.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34-(Glyc-AOct)-GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.26-(Glyc-AOct)-GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.38-(Glyc-AOct)-GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.34-(Glyc-AOct)-GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.26-(Glyc-AOct)-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.39-(Glyc-AOct)-GLP-1(7-39);
[0999] Ser.sup.8Arg.sup.26Lys.sup.34-(Glyc-AOct)-GLP-1(7-36);
Ser.sup.8Arg.sup.34Lys.sup.26-(Glyc-AOct)-GLP-1(7-36);
Ser.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-36);
Ser.sup.8Arg.sup.26Lys.sup.34(Glyc-AOct)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.34Lys.sup.26-(Glyc-AOct)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26Lys.sup.34-(Glyc-AOct)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26-(Glyc-AOct)-GLP-1(7-37);
Ser.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34-(Glyc-AOct)-GLP-1(7-38);
Ser.sup.8Arg.sup.34Lys.sup.26-(Glyc-AOct)-GLP-1(7-38);
Ser.sup.8Arg.sup.26,34Lys.sup.38-(Glyc-AOct)-GLP-1(7-38);
Ser.sup.8Arg.sup.26Lys.sup.34-(Glyc-AOct)-GLP-1(7-39);
Ser.sup.8Arg.sup.34Lys.sup.26-(Glyc-AOct)-GLP-1(7-39);
Ser.sup.8Arg.sup.26,34Lys.sup.39-(Glyc-AOct)-GLP-1(7-39);
[1000] Thr.sup.8Arg.sup.26Lys.sup.34-(Glyc-AOct)-GLP-1(7-36);
Thr.sup.8Arg.sup.34Lys.sup.26-(Glyc-AOct)-GLP-1(7-36);
Thr.sup.8Arg.sup.26Lys.sup.36-(Glyc-AOct)-GLP-1(7-36);
Thr.sup.8Arg.sup.26Lys.sup.34-(Glyc-AOct)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.34Lys.sup.26-(Glyc-AOct)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.26Lys.sup.34-(Glyc-AOct)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26-(Glyc-AOct)-GLP-1(7-37);
Thr.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34-(Glyc-AOct)-GLP-1(7-38);
Thr.sup.8Arg.sup.34Lys.sup.26-(Glyc-AOct)-GLP-1(7-38);
Thr.sup.8Arg.sup.26,34Lys.sup.38-(Glyc-AOct)-GLP-1(7-38);
Thr.sup.8Arg.sup.26Lys.sup.34-(Glyc-AOct)-GLP-1(7-39);
Thr.sup.8Arg.sup.34Lys.sup.26-(Glyc-AOct)-GLP-1(7-39);
Thr.sup.8Arg.sup.26,34Lys.sup.39-(Glyc-AOct)-GLP-1(7-39);
[1001]
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-36)-
;
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-AOct)-GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-AOct)-GLP-1(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-AOct)-GLP-1(7-39);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-36);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-AOct)-GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-AOct)-GLP-1(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-AOct)-GLP-(7-39);
[1002]
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-36)-
;
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-AOct)-GLP-1(7-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-AOct)-GLP-1(7-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-AOct)-GLP-1(7-39);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-36);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36(Glyc-AOct)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-AOct)-GLP-1(7-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-AOct)-GLP-1(7-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-AOct)-GLP-1(7-39);
[1003]
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-36)-
;
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-AOct)-GLP-1(7-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-AOct)-GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-AOct)-GLP-1(7-39);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-36);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-AOct)-GLP-1(7-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-AOct)-GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-AOct)-GLP-1(7-39);
[1004]
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-36)-
;
Val.sup.8Asp.sup.35Arg26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-AOct)-GLP-1(7-37);
Val.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-AOct)-GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-AOct)-GLP-1(7-39);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-36);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36
(Glyc-AOct)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-AOct)-GLP-1(7-37);
Val.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-AOct)-GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-AOct)-GLP-1(7-39);
[1005]
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-36)-
;
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-AOct)-GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-AOct)-GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-AOct)-GLP-1(7-39);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-36);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-AOct)-GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-AOct)-GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-AOct)-GLP-1(7-39);
[1006]
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-36)-
;
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-AOct)-GLP-1(7-37);
Ser.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-AOct)-GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39(Glyc-AOct)-GLP-1(7-39);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-36);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-AOct)-GLP-1(7-37);
Ser.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-AOct)-GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-AOct)-GLP-1(7-39);
[1007]
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-36)-
;
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-AOct)-GLP-1(7-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-AOct)-GLP-1(7-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-AOct)-GLP-1(7-39);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-36);
Th.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36(Glyc-AOct)-GLP-1(7-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-AOct)-GLP-1(7-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-AOct)-GLP-1(7-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-AOct)-GLP-1(7-39);
[1008]
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-36)-
;
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-AOct)-GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-AOct)-GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-AOct)-GLP-1(7-39);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-36);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-AOct)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-AOct)-GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-AOct)-GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-AOct)-GLP-1(7-39);
[1009] Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-1(7-38);
[1010] Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-38);
[1011] Arg.sup.26,34Lys.sup.27(Glyc-AOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-38);
[1012] Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-1(7-38);
[1013] Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-38);
[1014] Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-38);
[1015] Arg.sup.26,34Lys.sup.18(Glyc-AOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-1(7-38);
[1016] Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-38);
[1017] Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-38);
[1018] Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-AOct)-GLP-1(7-38);
[1019] Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-AOct)-GLP-1(7-38);
[1020] Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-AOct)-GLP-1(7-38);
[1021] Arg.sup.26Lys.sup.34-(Glyc-ALit)-GLP-1(7-36);
Arg.sup.34Lys.sup.26-(Glyc-ALit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-36);
Arg.sup.26Lys.sup.34-(Glyc-ALit)-GLP-1(7-36)amide;
Arg.sup.34Lys.sup.26-(Glyc-ALit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-36)amide;
Arg.sup.26Lys.sup.34-(Glyc-ALit)-GLP-1(7-37);
Arg.sup.34Lys.sup.26-(Glyc-ALit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-37);
Arg.sup.26Lys.sup.34-(Glyc-ALit)-GLP-1(7-38);
Arg.sup.34Lys.sup.26-(Glyc-ALit)-GLP-1(7-38);
Arg.sup.26,34Lys.sup.38-(Glyc-ALit)-GLP-1(7-38);
Arg.sup.26Lys.sup.34-(Glyc-ALit)-GLP-1(7-39);
Arg.sup.34Lys.sup.26-(Glyc-ALit)-GLP-1(7-39);
Arg.sup.26,34Lys.sup.39-(Glyc-ALit)-GLP-1(7-39);
[1022] Gly.sup.8Arg.sup.26Lys.sup.34-(Glyc-ALit)-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.26-(Glyc-ALit)-GLP-1(7-36);
Gly.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.34-(Glyc-ALit)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.34Lys.sup.26-(Glyc-ALit)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26Lys.sup.34-(Glyc-ALit)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26-(Glyc-ALit)-GLP-1(7-37);
Gly.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34-(Glyc-ALit)-GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.26-(Glyc-ALit)-GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.38-(Glyc-ALit)-GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.34-(Glyc-ALit)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26-(Glyc-ALit)-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.39-(Glyc-ALit)-GLP-1(7-39);
[1023] Val.sup.8Arg.sup.26Lys.sup.34-(Glyc-ALit)-GLP-1(7-36); );
Val.sup.8Arg.sup.34Lys.sup.26-(Glyc-ALit)-GLP-1(7-36);
Val.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26Lys.sup.34(Glyc-ALit)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.34Lys.sup.26-(Glyc-ALit)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26Lys.sup.34-(Glyc-ALit)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26-(Glyc-ALit)-GLP-1(7-37);
Val.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-Lit)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34-(Glyc-ALit)-GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.26-(Glyc-ALit)-GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.38-(Glyc-ALit)-GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.34-(Glyc-ALit)-GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.26-(Glyc-ALit)-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.39-(Glyc-ALit)-GLP-1(7-39);
[1024] Ser.sup.8Arg.sup.26Lys.sup.34-(Glyc-ALit)-GLP-1(7-36);
Ser.sup.8Arg.sup.34Lys.sup.26-(Glyc-ALit)-GLP-1(7-36);
Ser.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-36);
Ser.sup.8Arg.sup.26Lys.sup.34-(Glyc-ALit)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.34Lys.sup.26-(Glyc-ALit)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1 (7-36)amide;
Ser.sup.8Arg.sup.26Lys.sup.34-ALit)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26-(Glyc-ALit)-GLP-1(7-37);
Ser.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34-(Glyc-ALit)-GLP-1(7-38);
Ser.sup.8Arg.sup.34Lys.sup.26-(Glyc-ALit)-GLP-1(7-38);
Ser.sup.8Arg.sup.26,34Lys.sup.38-(Glyc-ALit)-GLP-1(7-38);
Ser.sup.8Arg.sup.26Lys.sup.34-(Glyc-ALit)-GLP-1(7-39);
Ser.sup.8Arg.sup.34Lys.sup.26-(Glyc-ALit)-GLP-1(7-39);
Ser.sup.8Arg.sup.26,34Lys.sup.39-(Glyc-ALit)-GLP-1(7-39);
[1025] Thr.sup.8Arg.sup.26Lys.sup.34-(Glyc-ALit)-GLP-1(7-36);
Thr.sup.8Arg.sup.34Lys.sup.26-(Glyc-ALit)-GLP-1(7-36);
Thr.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-36);
Thr.sup.8Arg.sup.26Lys.sup.34-(Glyc-ALit)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.34Lys.sup.26-(Glyc-ALit)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.26Lys.sup.34-(Glyc-ALit)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26-(Glyc-ALit)-GLP-1(7-37);
Thr.sup.8Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-37);
Thr.sup.8Arg.sup.8Arg.sup.26Lys.sup.34-(Glyc-ALit)-GLP-1(7-38);
Thr.sup.8Arg.sup.34Lys.sup.26-(Glyc-ALit)-GLP-1(7-38);
Thr.sup.8Arg.sup.26,34Lys.sup.38-(Glyc-ALit)-GLP-1(7-38);
Thr.sup.8Arg.sup.26Lys.sup.34-(Glyc-ALit)-GLP-1(7-39);
Thr.sup.8Arg.sup.34Lys.sup.26-(Glyc-ALit)-GLP-1(7-39);
Thr.sup.8Arg.sup.26,34Lys.sup.39-(Glyc-ALit)-GLP-1(7-39);
[1026]
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-36)-
;
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ALit)-GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ALit)-GLP-1(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ALit)-GLP-1(7-39);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-36);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ALit)-GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ALit)-GLP-1(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ALit)-GLP-1(7-39);
[1027]
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-36)-
;
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ALit)-GLP-1(7-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ALit)-GLP-1(7-38);
Gly.sub.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ALit)-GLP-1(7-39);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-36);
Gly.sup.8Asp.sup.35Arg.sup.26,34Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1-
(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ALit)-GLP-1(7-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ALit)-GLP-1(7-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ALit)-GLP-1(7-39);
[1028]
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-36)-
;
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ALit)-GLP-1(7-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ALit)-GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ALit)-GLP-1(7-39);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-36);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ALit)-GLP-1(7-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ALit)-GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ALit)-GLP-1(7-39);
[1029]
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-36)-
;
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ALit)-GLP-1(7-37);
Val.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ALit)-GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ALit)-GLP-1(7-39);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-36);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ALit)-GLP-1(7-37);
Val.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ALit)-GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ALit)-GLP-1(7-39);
[1030]
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-36)-
;
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ALit)-GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ALit)-GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ALit)-GLP-1(7-39);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-36);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ALit)-GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ALit)-GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ALit)-GLP-1(7-39);
[1031]
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-36)-
;
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ALit)-GLP-1(7-37);
Ser.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ALit)-GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ALit)-GLP-1(7-39);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-36);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ALit)-GLP-1(7-37);
Ser.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ALit)-GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ALit)-GLP-1(7-39);
[1032]
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-36)-
;
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ALit)-GLP-1(7-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ALit)-GLP-1(7-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ALit)-GLP-1(7-39);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-36);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ALit)-GLP-1(7-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ALit)-GLP-1(7-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ALit)-GLP-1(7-39);
[1033]
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-36)-
;
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ALit)-GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.28-(Glyc-ALit)-GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ALit)-GLP-1(7-39);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-36);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(Glyc-ALit)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(Glyc-ALit)-GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(Glyc-ALit)-GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(Glyc-ALit)-GLP-1(7-39);
[1034] Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-38);
[1035] Arg.sup.26,34Lys.sup.23-(Glyc-ALit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Glyc-ALit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Glyc-ALit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Glyc-ALit)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ALit)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-ALit)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ALit)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-ALit)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ALit)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ALit)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-ALit)-GLP-1(7-38);
[1036] Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-38);
Gly.sub.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-38);
[1037] Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-38);
[1038] Arg.sup.26,34Lys.sup.23-(Glyc-ALit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Glyc-ALit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Glyc-ALit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Glyc-ALit)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ALit)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-ALit)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ALit)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-ALit)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ALit)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ALit)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-ALit)-GLP-1(7-38);
[1039] Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-38);
[1040] Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-38);
[1041] Arg.sup.26,34Lys.sup.23-(Glyc-ALit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Glyc-ALit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(Glyc-ALit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Glyc-ALit)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ALit)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-ALit)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ALit)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-ALit)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ALit)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ALit)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-ALit)-GLP-1(7-38);
[1042] Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-38);
[1043] Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(Glyc-ALit)-GLP-1(7-38);
[1044] Arg.sup.26,34Lys.sup.23-(Glyc-ALit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(Glyc-ALit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23(Glyc-ALit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(Glyc-ALit)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ALit)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-ALit)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ALit)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23(Glyc-ALit)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ALit)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(Glyc-ALit)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(Glyc-ALit)-GLP-1(7-38);
[1045] Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(Glyc-ALit)-GLP-1(7-38);
[1046] Arg.sup.26Lys.sup.34-(GAB-GDod)-GLP-1(7-36);
Arg.sup.34Lys.sup.26-(GAB-GDod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-36);
Arg.sup.26Lys.sup.34-(GAB-GDod)-GLP-1(7-36)amide;
Arg.sup.34Lys.sup.26-(GAB-GDod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-36)amide;
Arg.sup.26Lys.sup.34-(GAB-GDod)-GLP-1(7-37);
Arg.sup.34Lys.sup.26-(GAB-GDod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-37);
Arg.sup.26Lys.sup.34-(GAB-GDod)-GLP-1(7-38);
Arg.sup.34Lys.sup.26-(GAB-GDod)-GLP-1(7-38);
Arg.sup.26,34Lys.sup.38-(GAB-GDod)-GLP-1(7-38);
Arg.sup.26Lys.sup.34-(GAB-GDod)-GLP-1(7-39);
Arg.sup.34Lys.sup.26-(GAB-GDod)-GLP-1(7-39);
Arg.sup.26,34Lys.sup.39-(GAB-GDod)-GLP-1(7-39);
[1047] Gly.sup.8Arg.sup.26Lys.sup.34-(GAB-GDod)-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.26-(GAB-GDod)-GLP-1(7-36);
Gly.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.34-(GAB-GDod)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.34Lys.sup.26-(GAB-GDod)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26Lys.sup.34-(GAB-GDod)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26-(GAB-GDod)-GLP-1(7-37);
Gly.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34-(GAB-GDod)-GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.26-(GAB-GDod)-GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.38-(GAB-GDod)-GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.34-(GAB-GDod)-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.26-(GAB-GDod)-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.39-(GAB-GDod)-GLP-1(7-39);
[1048] Val.sup.8Arg.sup.26Lys.sup.34-(GAB-GDod)-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.26-(GAB-GDod)-GLP-1(7-36);
Val.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.34-(GAB-GDod)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.34Lys.sup.26-(GAB-GDod)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26Lys.sup.34-(GAB-GDod)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26-(GAB-GDod)-GLP-1(7-37);
Val.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34-(GAB-GDod)-GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.26-(GAB-GDod)-GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.38-(GAB-GDod)-GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.34-(GAB-GDod)-GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.26-(GAB-GDod)-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.39-(GAB-GDod)-GLP-1(7-39);
[1049] Ser.sup.8Arg.sup.26Lys.sup.34-(GAB-GDod)-GLP-1(7-36);
Ser.sup.8Arg.sup.34Lys.sup.26-(GAB-GDod)-GLP-1(7-36);
Ser.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-36);
Ser.sup.8Arg.sup.26Lys.sup.34-(GAB-GDod)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.34Lys.sup.26-(GAB-GDod)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26Lys.sup.34-(GAB-GDod)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26-(GAB-GDod)-GLP-1(7-37);
Ser.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34-(GAB-GDod)-GLP-1(7-38);
Ser.sup.8Arg.sup.34Lys.sup.26-(GAB-GDod)-GLP-1(7-38);
Ser.sup.8Arg.sup.26,34Lys.sup.38-(GAB-GDod)-GLP-1(7-38);
Ser.sup.8Arg.sup.26Lys.sup.34-(GAB-GDod)-GLP-1(7-39);
Ser.sup.8Arg.sup.34Lys.sup.26-(GAB-GDod)-GLP-1(7-39);
Ser.sup.8Arg.sup.26,34Lys.sup.39-(GAB-GDod)-GLP-1(7-39);
[1050] Thr.sup.8Arg.sup.26Lys.sup.34-(GAB-GDod)-GLP-1(7-36);
Thr.sup.8Arg.sup.34Lys.sup.26-(GAB-GDod)-GLP-1(7-36);
Thr.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-36);
Thr.sup.8Arg.sup.26Lys.sup.34-(GAB-GDod)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.34Lys.sup.26-(GAB-GDod)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.26Lys.sup.34-(GAB-GDod)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26-(GAB-GDod)-GLP-1(7-37);
Thr.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34(GAB-GDod)-GLP-1(7-38);
Thr.sup.8Arg.sup.34Lys.sup.26-(GAB-GDod)-GLP-1(7-38);
Th.sup.8Arg.sup.26,34Lys.sup.38-(GAB-GDod)-GLP-1(7-38);
Thr.sup.8Arg.sup.26Lys.sup.34-(GAB-GDod)-GLP-1(7-39);
Thr.sup.8Arg.sup.34Lys.sup.26(GAB-GDod)-GLP-1(7-39);
Thr.sup.8Arg.sup.26,34Lys.sup.39-(GAB-GDod)-GLP-1(7-39);
[1051] Gly.sup.8Glu.sup.35Arg.sup.34,26-(GAB-GDod)-GLP-1(7-36);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-GAB-GDod)-GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GDod)-GLP-1(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GDod)-GLP-1(7-39);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-36);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37(GAB-GDod)-GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GDod)-GLP-1(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GDod)-GLP-1(7-39);
[1052]
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-36);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GDod)-GLP-1(7-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GDod)-GLP-1(7-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GDod)-GLP-1(7-39);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-36);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GDod)-GLP-1(7-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GDod)-GLP-1(7-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GDod)-GLP-1(7-39);
[1053]
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-36);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GDod)-GLP-1(7-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GDod)-GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GDod)-GLP-1(7-39);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-36);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GDod)-GLP-1(7-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GDod)-GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GDod)-GLP-1(7-39);
[1054]
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-36);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GDod)-GLP-1(7-37);
Val.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GDod)-GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GDod)-GLP-1(7-39);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-36);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GDod)-GLP-1(7-37);
Val.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GDod)-GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GDod)-GLP-1(7-39);
[1055]
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-36);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GDod)-GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GDod)-GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GDod)-GLP-1(7-39);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-36);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GDod)-GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GDod)-GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GDod)-GLP-1(7-39);
[1056]
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-36);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GDod)-GLP-1(7-37);
Ser.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GDod)-GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GDod)-GLP-1(7-39);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-36);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GDod)-GLP-1(7-37);
Ser.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GDod)-GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GDod)-GLP-1(7-39);
[1057]
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-36);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GDod)-GLP-1(7-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GDod)-GLP-1(7-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GDod)-GLP-1(7-39);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-36);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GDod)-GLP-1(7-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GDod)-GLP-1(7-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GDod)-GLP-1(7-39);
[1058]
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-36);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GDod)-GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GDod)-GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GDod)-GLP-1(7-39);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-36);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GDod)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GDod)-GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GDod)-GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GDod)-GLP-1(7-39);
[1059] Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-38);
[1060] Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-38);
[1061] Arg.sup.26,34Lys.sup.27-(GAB-GDod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(GAB-GDod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27(GAB-GDod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(GAB-GDod)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GDod)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GDod)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GDod)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GDod)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GDod)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GDod)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GDod)-GLP-1(7-38);
[1062] Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-38);
[1063] Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-38);
[1064] Arg.sup.26,34Lys.sup.27-(GAB-GDod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(GAB-GDod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(GAB-GDod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(GAB-GDod)-LP-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GDod)-GLP-1-(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GDod)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GDod)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GDod)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GDod)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GDod)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GDod)-GLP-1(7-38);
[1065] Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-38);
[1066] Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-38);
[1067] Arg.sup.26,34Lys.sup.27-(GAB-GDod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(GAB-GDod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(GAB-GDod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(GAB-GDod)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GDod)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GDod)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GDod)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GDod)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GDod)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GDod)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GDod)-GLP-1(7-38);
[1068] Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GDod)-GLP-1(7-38);
[1069] Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GDod)-GLP-1(7-38);
[1070] Arg.sup.26,34Lys.sup.27-(GAB-GDod)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(GAB-GDod)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(GAB-GDod)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(GAB-GDod)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GDod)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GDod)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GDod)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GDod)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GDod)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GDod)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GDod)-GLP-1(7-38);
[1071] Arg.sup.26Lys.sup.34-(GAB-GTet)-GLP-1(7-36);
Arg.sup.34Lys.sup.26-(GAB-GTet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-36);
Arg.sup.26Lys.sup.34-(GAB-GTet)-GLP-1(7-36)amide;
Arg.sup.34Lys.sup.26-(GAB-GTet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-36)amide;
Arg.sup.26Lys.sup.34-(GAB-GTet)-GLP-1(7-37);
Arg.sup.34Lys.sup.26-(GAB-GTet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-37);
Arg.sup.26Lys.sup.34-(GAB-GTet)-GLP-1(7-38);
Arg.sup.34Lys.sup.26-(GAB-GTet)-GLP-1(7-38);
Arg.sup.26,34Lys.sup.38-(GAB-GTet)-GLP-1(7-38);
Arg.sup.26Lys.sup.34-(GAB-GTet)-GLP-1(7-39);
Arg.sup.34Lys.sup.26-(GAB-GTet)-GLP-1(7-39);
Arg.sup.26,34Lys.sup.39-(GAB-GTet)-GLP-1(7-39);
[1072] Gly.sup.8Arg.sup.26Lys.sup.34-(GAB-GTet)-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.26-(GAB-GTet)-GLP-1(7-36);
Gly.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.34-(GAB-GTet)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.34Lys.sup.26-(GAB-GTet)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26Lys.sup.34-(GAB-GTet)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26-(GAB-GTet)-GLP-1(7-37);
Gly.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34-(GAB-GTet)-GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.26-(GAB-GTet)-GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.38-(GAB-GTet)-GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.34-(GAB-GTet)-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.26-(GAB-GTet)-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.39-(GAB-GTet)-GLP-1(7-39);
[1073] Val.sup.8Arg.sup.26Lys.sup.34-(GAB-GTet)-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.26-(GAB-GTet)-GLP-1(7-36);
Val.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.34-(GAB-GTet)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.34Lys.sup.26-(GAB-GTet)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26Lys.sup.34-(GAB-GTet)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26-(GAB-GTet)-GLP-1(7-37);
Val.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34-(GAB-GTet)-GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.26-(GAB-GTet)-GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.38-(GAB-GTet)-GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.34-(GAB-GTet)-GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.26-(GAB-GTet)-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.39-(GAB-GTet)-GLP-1(7-39);
[1074] Ser.sup.8Arg.sup.26Lys.sup.34-(GAB-GTet)-GLP-1(7-36);
Ser.sup.8Arg.sup.34Lys.sup.26-(GAB-GTet)-GLP-1(7-36);
Ser.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-36);
Ser.sup.8Arg.sup.26Lys.sup.34-(GAB-GTet)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.34Lys.sup.26-(GAB-GTet)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26Lys.sup.34-(GAB-GTet)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26-(GAB-GTet)-GLP-1(7-37);
Ser.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34-(GAB-GTet)-GLP-1(7-38);
Ser.sup.8Arg.sup.34Lys.sup.26-(GAB-GTet)-GLP-1(7-38;
Ser.sup.8Arg.sup.26,34Lys.sup.38-(GAB-GTet)-GLP-1(7-38);
Ser.sup.8Arg.sup.26Lys.sup.34-(GAB-GTet)-GLP-1(7-39);
Ser.sup.8Arg.sup.34Lys.sup.26-(GAB-GTet)-GLP-1(7-39);
Ser.sup.8Arg.sup.26,34Lys.sup.39-(GAB-GTet)-GLP-1(7-39);
[1075] Thr.sup.8Arg.sup.26Lys.sup.34-(GAB-GTet)-GLP-1(7-36);
Thr.sup.8Arg.sup.34Lys.sup.26-(GAB-GTet)-GLP-1(7-36);
Thr.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-36);
Thr.sup.8Arg.sup.26Lys.sup.34-(GAB-GTet)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.34Lys.sup.26-(GAB-GTet)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.26Lys.sup.34-(GAB-GTet)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26-(GAB-GTet)-GLP-1(7-37);
Thr.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34-(GAB-GTet)-GLP-1(7-38);
Thr.sup.8Arg.sup.34Lys.sup.26-(GAB-GTet)-GLP-1(7-38);
Thr.sup.8Arg.sup.26,34Lys.sup.38-(GAB-GTet)-GLP-1(7-38);
Thr.sup.8Arg.sup.26Lys.sup.34-(GAB-GTet)-GLP-1(7-39);
Thr.sup.8Arg.sup.34Lys.sup.26-(GAB-GTet)-GLP-1(7-39);
Thr.sup.8Arg.sup.26,34Lys.sup.39-(GAB-GTet)-GLP-1(7-39);
[1076]
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-36);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GTet)-GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GTet)-GLP-1(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GTet)-GLP-1(7-39);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-36);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GTet)-GLP-1(7-37);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.38-(GAB-GTet)-GLP-1(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GTet)-GLP-1(7-39);
[1077]
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-36);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GTet)-GLP-1(7-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GTet)-GLP-1(7-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GTet)-GLP-1(7-39);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-36);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GTet)-GLP-1(7-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GTet)-GLP-1(7-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GTet)-GLP-1(7-39);
[1078]
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-36);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GTet)-GLP-1(7-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GTet)-GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GTet)-GLP-1(7-39);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-36);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GTet)-GLP-1(7-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GTet)-GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GTet)-GLP-1(7-39);
[1079]
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-36);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GTet)-GLP-1(7-37);
Val.sup.8Asp.sup.37 Arg.sup.26,34Lys.sup.38-(GAB-GTet)-GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GTet)-GLP-1(7-39);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-36);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GTet)-GLP-1(7-37);
Val.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GTet)-GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GTet)-GLP-1(7-39);
[1080]
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-36);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GTet)-GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GTet)-GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GTet)-GLP-1(7-39);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-36);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GTet)-GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GTet)-GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GTet)-GLP-1(7-39);
[1081]
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-36);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GTet)-GLP-1(7-37);
Ser.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GTet)-GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GTet)-GLP-1(7-39);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-36);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GTet)-GLP-1(7-37);
Ser.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GTet)-GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GTet)-GLP-1(7-39);
[1082]
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-36);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GTet)-GLP-1(7-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GTet)-GLP-1(7-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GTet)-GLP-1(7-39);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-36);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GTet)-GLP-1(7-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GTet)-GLP-1(7-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GTet)-GLP-1(7-39);
[1083]
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-36);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GTet)-GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GTet)-GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GTet)-GLP-1(7-39);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-36);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GTet)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GTet)-GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GTet)-GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GTet)-GLP-1(7-39);
[1084] Arg.sup.26,34Lys.sup.18(GAB-GTet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(GAB-GTet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(GAB-GTet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(GAB-GTet)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GTet)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GTet)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GTet)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GTet)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GTet)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GTet)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GTet)-GLP-1(7-38);
[1085] Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-38);
[1086] Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-38);
[1087] Arg.sup.26,34Lys.sup.8-(GAB-GTet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(GAB-GTet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(GAB-GTet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(GAB-GTet)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GTet)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GTet)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GTet)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GTet)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GTet)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GTet)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GTet)-GLP-1(7-38);
[1088] Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-38);
[1089] Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-38);
[1090] Arg.sup.26,34Lys.sup.18-(GAB-GTet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(GAB-GTet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(GAB-GTet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(GAB-GTet)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GTet)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GTet)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GTet)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GTet)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GTet)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GTet)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GTet)-GLP-1(7-38);
[1091] Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-38);
[1092] Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-38);
[1093] Arg.sup.26,34Lys.sup.18-(GAB-GTet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(GAB-GTet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(GAB-GTet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(GAB-GTet)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GTet)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GTet)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GTet)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GTet)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GTet)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GTet)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GTet)-GLP-1(7-38);
[1094] Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GTet)-GLP-1(7-38);
[1095] Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GTet)-GLP-1(7-38);
[1096] Arg.sup.26Lys.sup.34-(GAB-GHex)-GLP-1(7-36);
Arg.sup.34Lys.sup.26-(GAB-GHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-36);
Arg.sup.26Lys.sup.34-(GAB-GHex)-GLP-1(7-36)amide;
Arg.sup.34Lys.sup.26-(GAB-GHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-36)amide;
Arg.sup.26Lys.sup.34-(GAB-GHex)-GLP-1(7-37);
Arg.sup.34Lys.sup.26-(GAB-GHex-GLP-1(7-37);
Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-37);
Arg.sup.26Lys.sup.34-(GAB-GHex)-GLP-1(7-38);
Arg.sup.34Lys.sup.26-(GAB-GHex)-GLP-1(7-38);
Arg.sup.26,34Lys.sup.38-(GAB-GHex)-GLP-1(7-38);
Arg.sup.26Lys.sup.34-(GAB-GHex)-GLP-1(7-39);
Arg.sup.34Lys.sup.26-(GAB-GHex)-GLP-1(7-39);
Arg.sup.26,34Lys.sup.39-(GAB-GHex)-GLP-1(7-39);
[1097] Gly.sup.8Arg.sup.26Lys.sup.34-(GAB-GHex)-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.26-(GAB-GHex)-GLP-1(7-36);
Gly.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.34-(GAB-GHex)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.34Lys.sup.26-(GAB-GHex)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26Lys.sup.34-(GAB-GHex)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26-(GAB-GHex)-GLP-1(7-37);
Gly.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34-(GAB-GHex)-GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.26-(GAB-GHex)-GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.38-(GAB-GHex)-GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.34-(GAB-GHex)-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.26-(GAB-GHex)-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.39-(GAB-GHex)-GLP-1(7-39);
[1098] Val.sup.8Arg.sup.26Lys.sup.34-(GAB-GHex)-GLP-8(7-36);
Val.sup.8Arg.sup.34Lys.sup.26(GAB-GHex)-GLP-1(7-36);
Val.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.34-(GAB-GHex)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.34Lys.sup.26-(GAB-GHex)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26Lys.sup.34-(GAB-GHex)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26-(GAB-GHex)-GLP-1(7-37);
Val.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34-(GAB-GHex)-GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.26-(GAB-GHex)-GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.38-(GAB-GHex)-GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.34-(GAB-GHex)-GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.26-(GAB-GHex)-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.39-(GAB-GHex)-GLP-1(7-39);
[1099] Ser.sup.8Arg.sup.26Lys.sup.34-(GAB-GHex)-GLP-1(7-36);
Ser.sup.8Arg.sup.34Lys.sup.26-(GAB-GHex)-GLP-1(7-36);
Ser.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-36);
Ser.sup.8Arg.sup.26Lys.sup.34-(GAB-GHex)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.34Lys.sup.26-(GAB-GHex)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26Lys.sup.34-(GAB-GHex)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26-(GAB-GHex)-GLP-1(7-37);
Ser.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34-(GAB-GHex)-GLP-1(7-38);
Ser.sup.8Arg.sup.34Lys.sup.26-(GAB-GHex)-GLP-1(7-38);
Ser.sup.8Arg.sup.26,34Lys.sup.38-(GAB-GHex)-GLP-1(7-38);
Ser.sup.8Arg.sup.26Lys.sup.34-(GAB-GHex)-GLP-1(7-39);
Ser.sup.8Arg.sup.34Lys.sup.26-(GAB-GHex)-GLP-1(7-39);
Ser.sup.8Arg.sup.26,34Lys.sup.39-(GAB-GHex)-GLP-1(7-39);
[1100] Thr.sup.8Arg.sup.26Lys.sup.34-(GAB-GHex)-GLP-1(7-36);
Thr.sup.8Arg.sup.34Lys.sup.26-(GAB-GHex)-GLP-1(7-36);
Thr.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-36);
Thr.sup.8Arg.sup.26Lys.sup.34-(GAB-GHex)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.34Lys.sup.26-(GAB-GHex)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.26,34Lys.sup.36(GAB-GHex)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.26Lys.sup.34-(GAB-GHex)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26-(GAB-GHex)-GLP-1(7-37);
Thr.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34(GAB-GHex)-GLP-1(7-38);
Thr.sup.8Arg.sup.34Lys.sup.26-(GAB-GHex)-GLP-1(7-38);
Thr.sup.8Arg.sup.26,34Lys.sup.38-(GAB-GHex)-GLP-1(7-38);
Thr.sup.8Arg.sup.26Lys.sup.34-(GAB-GHex)-GLP-1(7-39);
Thr.sup.8Arg.sup.34Lys.sup.26-(GAB-GHex)-GLP-1(7-39);
Thr.sup.8Arg.sup.26,34Lys.sup.39-(GAB-GHex)-GLP-1(7-39);
[1101]
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-318(7-36-
);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GHex)-GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38(GAB-GHex)-GLP-1(7-38);
Gly.sup.8Gly.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GHex)-GLP-1(7-39);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-36);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GHex)-GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.3-(GAB-GHex)-GLP-1(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GHex)-GLP-1(7-39);
[1102]
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-36);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GHex)-GLP-1(7-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GHex)-GLP-1(7-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GHex)-GLP-1(7-39);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-36);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GHex)-GLP-1(7-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GHex)-GLP-1(7-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GHex)-GLP-1(7-39);
[1103]
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-36);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GHex)-GLP-1(7-37);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GHex)-GLP-1(7-39);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-36);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36(GAB-GHex)-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GHex)-GLP-1(7-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GHex)-GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GHex)-GLP-1(7-39);
[1104]
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-36);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GHex)-GLP-1(7-37);
Val.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GHex)-GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GHex)-GLP-1(7-39);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-36);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GHex)-GLP-1(7-37);
Val.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GHex)-GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GHex)-GLP-1(7-39);
[1105]
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-36);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GHex)-GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GHex)-GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GHex)-GLP-1(7-39);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-36);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GHex)-GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GHex)-GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GHex)-GLP-1(7-39);
[1106]
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-36);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GHex)-GLP-1(7-37);
Ser.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GHex)-GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GHex)-GLP-1(7-39);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-36);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GHex)-GLP-1(7-37);
Ser.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GHex)-GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GHex)-GLP-1(7-39);
[1107]
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-36);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GHex)-GLP-1(7-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GHex)-GLP-1(7-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GHex)-GLP-1(7-39);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-36);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36(GAB-GHex)-GLP-1(7-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GHex)-GLP-1(7-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GHex)-GLP-1(7-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GHex)1-GLP-1(7-39);
[1108]
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-36);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34 Lys.sup.37-(GAB-GHex)-GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(GAB-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GHex)-GLP-1(7-39);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GHex)-GLP-1(7-39);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GHex)-GLP-1(7-36);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36(AB-GHex)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GHex)-GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GHex)-GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GHex)-GLP-1(7-39);
[1109] Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-38);
[1110] Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-38);
[1111] Arg.sup.26,34Lys.sup.27-(GAB-GHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(GAB-GHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(GAB-GHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(GAB-GHex)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GHex)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GHex)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GHex)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GHex)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GHex)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GHex)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GHex)-GLP-1(7-38);
[1112] Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-38);
[1113] Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-38);
[1114] Arg.sup.26,34Lys.sup.27-(GAB-GHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(GAB-GHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(GAB-GHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(GAB-GHex)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GHex)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GHex)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GHex)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GHex)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GHex)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GHex)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GHex)-GLP-1(7-38);
[1115] Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-38);
[1116] Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-38);
[1117] Arg.sup.26,34Lys.sup.27-(GAB-GHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(GAB-GHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(GAB-GHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(GAB-GHex)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GHex)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GHex)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GHex)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GHex)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GHex)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GHex)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27(GAB-GHex)-GLP-1(7-38);
[1118] Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18A-(GAB-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GHex)-GLP-1(7-38);
[1119] Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GHex)-GLP-1(7-38);
[1120] Arg.sup.26,34Lys.sup.27(GAB-GHex)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(GAB-GHex)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(GAB-GHex)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(GAB-GHex)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GHex)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GHex)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.21,34Lys.sup.27-(GAB-GHex)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GHex)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GHex)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GHex)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GHex)-GLP-1(7-38);
[1121] Arg.sup.26Lys.sup.34-(GAB-GOct)-GLP-1(7-36);
Arg.sup.34Lys.sup.26-(GAB-GOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-36);
Arg.sup.26Lys.sup.34-(GAB-GOct)-GLP-1(7-36)amide;
Arg.sup.34Lys.sup.26(GAB-GOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-36)amide;
Arg.sup.26Lys.sup.34-(GAB-GOct)-GLP-1(7-37);
Arg.sup.34Lys.sup.26-(GAB-GOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-37);
Arg.sup.26Lys.sup.34-(GAB-GOct)-GLP-1(7-38);
Arg.sup.34Lys.sup.26-(GAB-GOct)-GLP-1(7-38);
Arg.sup.26,34Lys.sup.38-(GAB-GOct)-GLP-1(7-38);
Arg.sup.26Lys.sup.34-(GAB-GOct)-GLP-1(7-39);
Arg.sup.34Lys.sup.26-(GAB-GOct)-GLP-1(7-39);
Arg.sup.26,34Lys.sup.39-(GAB-GOct)-GLP-1(7-39);
[1122] Gly.sup.8Arg.sup.26Lys.sup.34-(GAB-GOct)-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.26-(GAB-GOct)-GLP-1(7-36);
Gly.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.34-(GAB-GOct)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.34Lys.sup.26-GLP-(GAB-GOct)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26Lys.sup.34-(GAB-GOct)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26-(GAB-GOct)-GLP-1(7-37);
Gly.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34-(GAB-GOct)-GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.26-(GAB-GOct)-GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.38-(GAB-GOct)-GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.34-(GAB-GOct)-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.26-(GAB-GOct)-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.39-(GAB-GOct)-GLP-1(7-39);
[1123] Val.sup.8Arg.sup.26Lys.sup.34-(GAB-GOct)-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.26-(GAB-GOct)-GLP-1(7-36);
Val.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.34-(GAB-GOct)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.34Lys.sup.26-(GAB-GOct)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26Lys.sup.34-(GAB-GOct)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26-(GAB-GOct)-GLP-1(7-37);
Val.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34-(GAB-GOct)-GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.26-(GAB-GOct)-GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.38-(GAB-GOct)-GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.34-(GAB-GOct)-GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.26-(GAB-GOct)-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.39-(GAB-GOct)-GLP-1(7-39);
[1124] Ser.sup.8Arg.sup.26Lys.sup.34-(GAB-GOct)-GLP-1(7-36);
Ser.sup.8Arg.sup.34Lys.sup.26-(GAB-GOct)-GLP-1(7-36);
Ser.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-36);
Ser.sup.8Arg.sup.26Lys.sup.34-(GAB-GOct)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.34Lys.sup.26-(GAB-GOct)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26Lys.sup.34-(GAB-GOct)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26-(GAB-GOct)-GLP-1(7-37);
Ser.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34-(GAB-GOct)-GLP-1(7-38);
Ser.sup.8Arg.sup.34Lys.sup.26-(GAB-GOct)-GLP-1(7-38);
Ser.sup.8Arg.sup.26,34Lys.sup.38-(GAB-GOct)-GLP-1(7-38);
Ser.sup.8Arg.sup.26Lys.sup.34-(GAB-GOct)-GLP-1(7-39);
Ser.sup.8Arg.sup.34Lys.sup.26-(GAB-GOct)-GLP-1(7-39);
Ser.sup.8Arg.sup.26,34Lys.sup.39(GAB-GOct)-GLP-1(7-39);
[1125] Thr.sup.8Arg.sup.26Lys.sup.34-(GAB-GOct)-GLP-1(7-36);
Thr.sup.8Arg.sup.34Lys.sup.26-(GAB-GOct)-GLP-1(7-36);
Thr.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-36);
Thr.sup.8Arg.sup.26Lys.sup.34-(GAB-GOct)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.34Lys.sup.26-(GAB-GOct)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.26Lys.sup.34(GAB-GOct)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26-(GAB-GOct)-GLP-1(7-37);
Thr.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34-(GAB-GOct)-GLP-1(7-38);
Thr.sup.8Arg.sup.34Lys.sup.26-(GAB-GOct)-GLP-1(7-38);
Thr.sup.8Arg.sup.26,34Lys.sup.38-(GAB-GOct)-GLP-1(7-38);
Thr.sup.8Arg.sup.26Lys.sup.34-(GAB-GOct)-GLP-1(7-39);
Thr.sup.8Arg.sup.34Lys.sup.26-(GAB-GOct)-GLP-1(7-39);
Thr.sup.8Arg.sup.26,34Lys.sup.39-(GAB-GOct)-GLP-1(7-39);
[1126]
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-36);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GOct)-GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GOct)-GLP-1(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GOct)-GLP-1(7-39);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-36);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GOct)-GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GOct)-GLP-1(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GOct)-GLP-1(7-39);
[1127]
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-36);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GOct)-GLP-1(7-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GOct)-GLP-1(7-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GOct)-GLP-1(7-39);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-36);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36(GAB-GOct)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GOct)-GLP-1(7-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GOct)-GLP-1(7-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GOct)-GLP-1(7-39);
[1128]
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-36);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GOct)-GLP-1(7-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GOct)-GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GOct)-GLP-1(7-39);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-36);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GOct)-GLP-1(7-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GOct)-GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GOct)-GLP-1(7-39);
[1129]
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-36);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GOct)-GLP-1(7-37);
Val.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GOct)-GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GOct)-GLP-1(7-39);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-36);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36
(GAB-GOct)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GOct)-GLP-1(7-37);
Val.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GOct)-GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GOct)-GLP-1(7-39);
[1130]
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-36);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GOct)-GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GOct)-GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GOct)-GLP-1(7-39);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-36);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GOct)-GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GOct)-GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GOct)-GLP-1(7-39);
[1131]
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-36);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GOct)-GLP-1(7-37);
Ser.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GOct)-GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GOct)-GLP-1(7-39);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-36);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GOct)-GLP-1(7-37);
Ser.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GOct)-GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GOct)-GLP-1(7-39);
[1132]
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-36);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GOct)-GLP-1(7-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GOct)-GLP-1(7-38);
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.39-(GAB-GOct)-GLP-1(7-39);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-36);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36(GAB-GOct)-GLP-1(7-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GOct)-GLP-1(7-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GOct)-GLP-1(7-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GOct)-GLP-1(7-39);
[1133]
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-36);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GOct)-GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GOct)-GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GOct)-GLP-1(7-39);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-36);
Th.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GOct)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GOct)-GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GOct)-GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GOct)-GLP-1(7-39);
[1134] Arg.sup.26,34Lys.sup.18-(GAB-GOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(GAB-GOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(GAB-GOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(GAB-GOct)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GOct)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GOct)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GOct)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GOct)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GOct)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GOct)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GOct)-GLP-1(7-38);
[1135] Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-38);
[1136] Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-38);
[1137] Arg.sup.26,34Lys.sup.18-(GAB-GOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(GAB-GOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(GAB-GOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(GAB-GOct)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GOct)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GOct)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18(GAB-GOct)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GOct)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GOct)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GOct)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GOct)-GLP-1(7-38);
[1138] Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-38);
[1139] Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-38);
[1140] Arg.sup.26,34Lys.sup.18-(GAB-GOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(GAB-GOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(GAB-GOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(GAB-GOct)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GOct)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GOct)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GOct)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GOct)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GOct)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GOct)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GOct)-GLP-1(7-38);
[1141] Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-38);
[1142] Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-38);
[1143] Arg.sup.26,34Lys.sup.18(GAB-GOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(GAB-GOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(GAB-GOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(GAB-GOct)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GOct)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GOct)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GOct)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GOct)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GOct)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GOct)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GOct)-GLP-1(7-38);
[1144] Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GOct)-GLP-1(7-38);
[1145] Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GOct)-GLP-1(7-38);
[1146] Arg.sup.26Lys.sup.34-(GAB-GLit)-GLP-1(7-36);
Arg.sup.34Lys.sup.26-(GAB-GLit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-36);
Arg.sup.26Lys.sup.34-(GAB-GLit)-GLP-1(7-36)amide;
Arg.sup.34Lys.sup.26-(GAB-GLit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-36)amide;
Arg.sup.26Lys.sup.34-(GAB-GLit)-GLP-1(7-37);
Arg.sup.34Lys.sup.26-(GAB-GLit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-37);
Arg.sup.26Lys.sup.34-(GAB-GLit)-GLP-1(7-38);
Arg.sup.34Lys.sup.26-(GAB-GLit)-GLP-1(7-38);
Arg.sup.26,34Lys.sup.38-(GAB-GLit)-GLP-1(7-38);
Arg.sup.26Lys.sup.34-(GAB-GLit)-GLP-1(7-39);
Arg.sup.34Lys.sup.26-(GAB-GLit)-GLP-1(7-39);
Arg.sup.26,34Lys.sup.39-(GAB-GLit)-GLP-1(7-39);
[1147] Gly.sup.8Arg.sup.26Lys.sup.34-(GAB-GLit)-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.26-(GAB-GLit)-GLP-1(7-36);
Gly.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.34-(GAB-GLit)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.34Lys.sup.26-(GAB-GLit)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-36)amide;
Gly.sup.8Arg.sup.26Lys.sup.34-(GAB-GLit)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26-(GAB-GLit)-GLP-1(7-37);
Gly.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34-(GAB-GLit)-GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.26-(GAB-GLit)-GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.38-(GAB-GLit)-GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.34-(GAB-GLit)-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.26-(GAB-GLit)-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.39-(GAB-GLit)-GLP-1(7-39);
[1148] Val.sup.8Arg.sup.26Lys.sup.34-(GAB-GLit)-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.26-(GAB-GLit)-GLP-1(7-36);
Val.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.34-(GAB-GLit)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.34Lys.sup.26-(GAB-GLit)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-36)amide;
Val.sup.8Arg.sup.26Lys.sup.34-(GAB-GLit)-GLP-1(7-367);
Val.sup.8Arg.sup.34Lys.sup.26-(GAB-GLit)-GLP-1(7-37);
Val.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34-(GAB-GLit)-GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.26-(GAB-GLit)-GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.38-(GAB-GLit)-GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.34-(GAB-GLit)-GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.26-(GAB-GLit)-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.39-(GAB-GLit)-GLP-1(7-39);
[1149] Ser.sup.8Arg.sup.26Lys.sup.34-(GAB-GLit)-GLP-1(7-36);
Ser.sup.8Arg.sup.34Lys.sup.26-(GAB-GLit)-GLP-1(7-36);
Ser.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-36);
Ser.sup.8Arg.sup.26Lys.sup.34(GAB-GLit)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.34Lys.sup.26-(GAB-GLit)-GLP-1(7-36) amide;
Ser.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-36)amide;
Ser.sup.8Arg.sup.26Lys.sup.34-(GAB-GLit)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26-(GAB-GLit)-GLP-1(7-37);
Ser.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34-(GAB-GLit)-GLP-1(7-38);
Ser.sup.8Arg.sup.34Lys.sup.26-(GAB-GLit)-GLP-1(7-38);
Ser.sup.8Arg.sup.26,34Lys.sup.38-(GAB-GLit)-GLP-1(7-38);
Ser.sup.8Arg.sup.26Lys.sup.34-(GAB-GLit)-GLP-1(7-39);
Ser.sup.8Arg.sup.34Lys.sup.26-(GAB-GLit)-GLP-1(7-39);
Ser.sup.8Arg.sup.26,34Lys.sup.39-(GAB-GLit)-GLP-1(7-39);
[1150] Thr.sup.8Arg.sup.26Lys.sup.34-(GAB-GLit)-GLP-1(7-36);
Thr.sup.8Arg.sup.34Lys.sup.26-(GAB-GLit)-GLP-1(7-36);
Thr.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-36);
Thr.sup.8Arg.sup.26Lys.sup.34-(GAB-GLit)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.34Lys.sup.26-(GAB-GLit)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-36)amide;
Thr.sup.8Arg.sup.26Lys.sup.34-(GAB-GLit)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26-(GAB-GLit)-GLP-1(7-37);
Thr.sup.8Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34-(GAB-GLit)-GLP-1(7-38);
Thr.sup.8Arg.sup.34Lys.sup.26-(GAB-GLit)-GLP-1(7-38);
Thr.sup.8Arg.sup.26,34Lys.sup.38-(GAB-GLit)-GLP-1(7-38);
Thr.sup.8Arg.sup.26Lys.sup.34-(GAB-GLit)-GLP-1(7-39);
Thr.sup.8Arg.sup.34Lys.sup.26-(GAB-GLit)-GLP-1(7-39);
Thr.sup.8Arg.sup.26,34Lys.sup.39-(GAB-GLit)-GLP-1(7-39);
[1151]
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-36);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GLit)-GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GLit)-GLP-1(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GLit)-GLP-1(7-39);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-36);
Gly.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-36)amide;
Gly.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GLit)-GLP-1(7-37);
Gly.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GLit)-GLP-1(7-38);
Gly.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GLit)-GLP-1(7-39);
[1152]
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-36);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GLit)-GLP-1(7-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GLit)-GLP-1(7-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GLit)-GLP-1(7-39);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-36);
Gly.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GLit)-GLP-1(7-37);
Gly.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GLit)-GLP-1(7-38);
Gly.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GLit)-GLP-1(7-39);
[1153]
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-36);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GLit)-GLP-1(7-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GLit)-GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GLit)-GLP-1(7-39);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-36);
Val.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-36)amide;
Val.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GLit)-GLP-1(7-37);
Val.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GLit)-GLP-1(7-38);
Val.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GLit)-GLP-1(7-39);
[1154]
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-36);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GLit)-GLP-1(7-37);
Val.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GLit)-GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GLit)-GLP-1(7-39);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-36);
Val.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GLit)-GLP-1(7-37);
Val.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GLit)-GLP-1(7-38);
Val.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GLit)-GLP-1(7-39);
[1155]
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-36);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GLit)-GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GLit)-GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GLit)-GLP-1(7-39);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-36);
Ser.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-36)amide;
Ser.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GLit)-GLP-1(7-37);
Ser.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GLit)-GLP-1(7-38);
Ser.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GLit)-GLP-1(7-39);
[1156]
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-36);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GLit)-GLP-1(7-37);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.38-(GAB-GLit)-GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GLit)-GLP-1(7-39);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-36);
Ser.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GLit)-GLP-1(7-37);
Ser.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GLit)-GLP-1(7-38);
Ser.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GLit)-GLP-1(7-39);
[1157]
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-36);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GLit)-GLP-1(7-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GLit)-GLP-1(7-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GLit)-GLP-1(7-39);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-36);
Thr.sup.8Glu.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-36)amide;
Thr.sup.8Glu.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GLit)-GLP-1(7-37);
Thr.sup.8Glu.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GLit)-GLP-1(7-38);
Thr.sup.8Glu.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GLit)-GLP-1(7-39);
[1158]
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-36);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GLit)-GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GLit)-GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GLit)-GLP-1(7-39);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-36);
Thr.sup.8Asp.sup.35Arg.sup.26,34Lys.sup.36-(GAB-GLit)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.36Arg.sup.26,34Lys.sup.37-(GAB-GLit)-GLP-1(7-37);
Thr.sup.8Asp.sup.37Arg.sup.26,34Lys.sup.38-(GAB-GLit)-GLP-1(7-38);
Thr.sup.8Asp.sup.38Arg.sup.26,34Lys.sup.39-(GAB-GLit)-GLP-1(7-39);
[1159] Arg.sup.26,34Lys.sup.18(GAB-GLit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(GAB-GLit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18(GAB-GLit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(GAB-GLit)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GLit)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GLit)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GLit)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GLit)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GLit)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GLit)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GLit)-GLP-1(7-38);
[1160] Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-38);
Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-38);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-36);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-36);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-36)amide;
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-37);
Gly.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-38);
Gly.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-38);
[1161] Arg.sup.26,34Lys.sup.18-(GAB-GLit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(GAB-GLit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(GAB-GLit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(GAB-GLit)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GLit)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GLit)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GLit)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GLit)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GLit)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GLit)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GLit)-GLP-1(7-38);
[1162] Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-38);
[1163] Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-38);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-36);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-36);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-36)amide;
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-37);
Val.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-38);
Val.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-38);
[1164] Arg.sup.26,34Lys.sup.18-(GAB-GLit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(GAB-GLit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(GAB-GLit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(GAB-GLit)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GLit)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GLit)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GLit)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GLit)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GLit)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GLit)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GLit)-GLP-1(7-38);
[1165] Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.23,34Lys.sup.23-(GAB-GLit)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-38);
[1166] Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-38);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-36);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-36);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-36)amide;
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-37);
Ser.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-38);
Ser.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-38);
[1167] Arg.sup.26,34Lys.sup.18-(GAB-GLit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.18-(GAB-GLit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.18-(GAB-GLit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.18-(GAB-GLit)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GLit)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GLit)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GLit)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GLit)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GLit)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.18-(GAB-GLit)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.18-(GAB-GLit)-GLP-1(7-38);
[1168] Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.23-(GAB-GLit)-GLP-1(7-38);
[1169] Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-36)amide;
Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-37);
Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-38);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-36);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-36);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-36)amide;
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-37);
Thr.sup.8Asp.sup.19Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-38);
Thr.sup.8Asp.sup.17Arg.sup.26,34Lys.sup.27-(GAB-GLit)-GLP-1(7-38);
[1170] Other preferred derivatives of GLP-1 analogs of the present
invention are:
[1171] Lys.sup.26,34-bis-(Glut-ADod)-GLP-1(7-36);
Lys.sup.26,34-bis-(Glut-ADod)-GLP-1(7-37);
Lys.sup.26,34-bis-(Glut-ADod)-GLP-1(7-38);
Lys.sup.26,34-bis-(Glut-ADod)-GLP-1(7-39)
Arg.sup.26Lys.sup.34,36-bis-(Glut-ADod)-GLP-1(7-36);
Arg.sup.34Lys.sup.26,36-bis-(Glut-ADod)-GLP-1(7-36);
Arg.sup.26Lys.sup.34,36-bis-(Glut-ADod)-GLP-1(7-37);
Arg.sup.34Lys.sup.26,36-bis-(Glut-ADod)-GLP-1(7-37);
Arg.sup.26Lys.sup.34,37-bis-(Glut-ADod)-GLP-1(7-37);
Arg.sup.34Lys.sup.26,37-bis-(Glut-ADod)-GLP-1(7-37);
Arg.sup.26Lys.sup.34,39-bis-(Glut-ADod)-GLP-1(7-39);
Arg.sup.34Lys.sup.26,39-bis-(Glut-ADod)-GLP-1(7-39);
Arg.sup.26,34Lys.sup.36,39-bis-(Glut-ADod)-GLP-1(7-39);
[1172] Arg.sup.26Lys.sup.18,34-bis-(Glut-ADod)-GLP-1(7-36);
Arg.sup.34Lys.sup.18,26-bis-(Glut-ADod)-GLP-1(7-36);
Arg.sup.26Lys.sup.18,34-bis-(Glut-ADod)-GLP-1(7-37);
Arg.sup.34Lys.sup.18,26-bis-(Glut-ADod)-GLP-1(7-37);
Arg.sup.26Lys.sup.18,34-bis-(Glut-ADod)-GLP-1(7-38);
Arg.sup.34Lys.sup.18,26-bis-(Glut-ADod)-GLP-1(7-38);
Arg.sup.26Lys.sup.18,34-bis-(Glut-ADod)-GLP-1(7-39);
Arg.sup.34Lys.sup.18,26-bis-(Glut-ADod)-GLP-1(7-39);
Arg.sup.26Lys.sup.23,34-bis-(Glut-ADod)-GLP-1(7-36);
Arg.sup.34Lys.sup.23,26-bis-(Glut-ADod)-GLP-1(7-36);
Arg.sup.26Lys.sup.23,34-bis-(Glut-ADod)-GLP-1(7-37);
Arg.sup.34Lys.sup.23,26-bis-(Glut-ADod)-GLP-1(7-37);
Arg.sup.26Lys.sup.23,34-bis-(Glut-ADod)-GLP-1(7-38);
Arg.sup.34Lys.sup.23,26-bis-(Glut-ADod)-GLP-1(7-38);
Arg.sup.26Lys.sup.23,34-bis-(Glut-ADod)-GLP-1(7-39);
Arg.sup.34Lys.sup.23,26-bis-(Glut-ADod)-GLP-1(7-39);
Arg.sup.26Lys.sup.27,34-bis-(Glut-ADod)-GLP-1(7-36);
Arg.sup.34Lys.sup.27,26-bis-(Glut-ADod)-GLP-1(7-36);
Arg.sup.26Lys.sup.27,34-bis-(Glut-ADod)-GLP-1(7-37);
Arg.sup.34Lys.sup.27,26 bis-(Glut-ADod)-GLP-1(7-37);
Arg.sup.26Lys.sup.27,34-bis-(Glut-ADod)-GLP-1(7-38);
Arg.sup.34Lys.sup.27,26-bis-(Glut-ADod)-GLP-1(7-38);
Arg.sup.26Lys.sup.27,34-bis-(Glut-ADod)-GLP-1(7-39);
Arg.sup.34Lys.sup.27,26-bis-(Glut-ADod)-GLP-1(7-39);
Gly.sup.8Lys.sup.26,34-bis-(Glut-ADod)-GLP-1(7-36);
Gly.sup.8Lys.sup.26,34--bis-(Gut-ADod)-GLP-1(7-37);
Gly.sup.8Lys.sup.26,34-bis-(Glut-ADod)-GLP-1(7-38);
Gly.sup.8Lys.sup.26,34-bis-(Glut-ADod)-GLP-1(7-39)
Gly.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glut-ADod)-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glut-ADod)-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glut-ADod)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glut-ADod)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34,37-bis-(Glut-ADod)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26,37-bis-(Glut-ADod)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34,38-bis-(Glut-ADod)-GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.26,38-bis-(Glut-ADod)-GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Glut-ADod)-GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.34,39-bis-(Glut-ADod)-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.26,39-bis-(Glut-ADod)-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Glut-ADod)-GLP-1(7-39);
[1173] Val.sup.8Lys.sup.26,34-bis-(Glut-ADod)-GLP-1(7-36);
Val.sup.8Lys.sup.26,34-bis-(Glut-ADod)-GLP-1(7-37);
Val.sup.8Lys.sup.26,34-bis-(Glut-ADod)-GLP-1(7-38);
Val.sup.8Lys.sup.26,34-bis-(Glut-ADod)-GLP-1(7-39)
Val.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glut-ADod)-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glut-ADod)-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glut-ADod)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glut-ADod)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34,37-bis-(Glut-ADod)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26,37-bis-(Glut-ADod)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34,38-bis-(Glut-ADod)-GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.26,38-bis-(Glut-ADod)-GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Glut-ADod)-GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.34,39-bis-(Glut-ADod)-GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.26,39-bis-(Glut-ADod)-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Glut-ADod)-GLP-1(7-39);
[1174] Ser.sup.8Lys.sup.26,34-bis-(Glut-ADod)-GLP-1(7-36);
Ser.sup.8Lys.sup.26,34-bis-(Glut-ADod)-GLP-1(7-37);
Ser.sup.8Lys.sup.26,34-bis-(Glut-ADod)-GLP-1(7-38);
Ser.sup.8Lys.sup.26,34-bis-(Glut-ADod)-GLP-1(7-39)
Ser.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glut-ADod)-GLP-1(7-36);
Ser.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glut-ADod)-GLP-1(7-36);
Ser.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glut-ADod)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glut-ADod)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34,37-bis-(Glut-ADod)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26,37-bis-(Glut-ADod)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34,38-bis-(Glut-ADod)-GLP-1(7-38);
Ser.sup.8Arg.sup.34Lys.sup.26,38-bis-(Glut-ADod)-GLP-1(7-38);
Ser.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Glut-ADod)-GLP-1(7-38);
Ser.sup.8Arg.sup.26Lys.sup.34,39-bis-(Glut-ADod)-GLP-1(7-39);
Ser.sup.8Arg.sup.34Lys.sup.26,39-bis-(Glut-ADod)-GLP-1(7-39);
Ser.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Glut-ADod)-GLP-1(7-39);
[1175] Thr.sup.8Lys.sup.26,34-bis-(Glut-ADod)-GLP-1(7-36);
Thr.sup.8Lys.sup.26,34-bis-(Glut-ADod)-GLP-1(7-37);
Thr.sup.8Lys.sup.26,34-bis-(Glut-ADod)-GLP-1(7-38);
Thr.sup.8Lys.sup.26,34-bis-(Glut-ADod)-GLP-1(7-39)
Thr.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glut-ADod)-GLP-1(7-36);
Thr.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glut-ADod)-GLP-1(7-36);
Thr.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glut-ADod)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glut-ADod)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34,37-bis-(Glut-ADod)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26,37-bis-(Glut-ADod)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34,38-bis-(Glut-ADod)-GLP-1(7-38);
Thr.sup.8Arg.sup.34Lys.sup.26,38-bis-(Glut-ADod)-GLP-1(7-38);
Thr.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Glut-ADod)-GLP-1(7-38);
Thr.sup.8Arg.sup.26Lys.sup.34,39-bis-(Glut-ADod)-GLP-1(7-39);
Thr.sup.8Arg.sup.34Lys.sup.26,39-bis-(Glut-ADod)-GLP-1(7-39);
Thr.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Glut-ADod)-GLP-1(7-39);
Lys.sup.26,34-bis-(Glut-ATet)-GLP-1(7-36);
Lys.sup.26,34-bis-(Glut-ATet)-GLP-1(7-37);
Lys.sup.26,34-bis-(Glut-ATet)-GLP-1(7-38);
Lys.sup.26,34-bis-(Glut-ATet)-GLP-1(7-39)
[1176] Arg.sup.26Lys.sup.34,36-bis-(Glut-ATet)-GLP-1(7-36);
Arg.sup.34Lys.sup.26,36-bis-(Glut-ATet)-GLP-1(7-36);
Arg.sup.26Lys.sup.34,36-bis-(Glut-ATet)-GLP-1(7-37);
Arg.sup.34Lys.sup.26,36-bis-(Glut-ATet)-GLP-1(7-37);
Arg.sup.26Lys.sup.34,37-bis-(Glut-ATet)-GLP-1(7-37);
Arg.sup.34Lys.sup.26,37-bis-(Glut-ATet)-GLP-1(7-37);
Arg.sup.26Lys.sup.34,39-bis-(Glut-ATet)-GLP-1(7-39);
Arg.sup.34Lys.sup.26,39-bis-(Glut-ATet)-GLP-1(7-39);
Arg.sup.26,34Lys.sup.36,39-bis-(Glut-ATet)-GLP-1(7-39);
[1177] Arg.sup.26Lys.sup.18,34-bis-(Glut-ATet)-GLP-1(7-36);
Arg.sup.34Lys.sup.18,26-bis-(Glut-ATet)-GLP-1(7-36);
Arg.sup.26Lys.sup.18,34-bis-(Glut-ATet)-GLP-1(7-37);
Arg.sup.34Lys.sup.18,26-bis-(Glut-ATet)-GLP-1(7-37);
Arg.sup.26Lys.sup.18,34-bis-(Glut-ATet)-GLP-1(7-38);
Arg.sup.34Lys.sup.18,26-bis-(Glut-ATet)-GLP-1(7-38);
Arg.sup.26Lys.sup.18,34-bis-(Glut-ATet)-GLP-1(7-39);
Arg.sup.34Lys.sup.18,26-bis-(Glut-ATet)-GLP-1(7-39);
Arg.sup.26Lys.sup.23,34-bis-(Glut-ATet)-GLP-1(7-36);
Arg.sup.34Lys.sup.23,26-bis-(Glut-ATet)-GLP-1(7-36);
Arg.sup.26Lys.sup.23,34-bis-(Glut-ATet)-GLP-1(7-37);
Arg.sup.34Lys.sup.23,26-bis-(Glut-ATet)-GLP-1(7-37);
Arg.sup.26Lys.sup.23,34-bis-(Glut-ATet)-GLP-1(7-38);
Arg.sup.34Lys.sup.23,26-bis-(Glut-ATet)-GLP-1(7-38);
Arg.sup.26Lys.sup.23,34-bis-(Glut-ATet)-GLP-1(7-39);
Arg.sup.34Lys.sup.23,26-bis-(Glut-ATet)-GLP-1(7-39);
Arg.sup.26Lys.sup.27,34-bis-(Glut-ATet)-GLP-1(7-36);
Arg.sup.34Lys.sup.27,26-bis-(Glut-ATet)-GLP-1(7-36);
Arg.sup.26Lys.sup.27,34-bis-(Glut-ATet)-GLP-1(7-37);
Arg.sup.34Lys.sup.27,26-bis-(Glut-ATet)-GLP-1(7-37);
Arg.sup.26Lys.sup.27,34-bis-(Glut-ATet)-GLP-1(7-38);
Arg.sup.34Lys.sup.27,26-bis-(Glut-ATet)-GLP-1(7-38);
Arg.sup.26Lys.sup.27,34-bis-(Glut-ATet)-GLP-1(7-39);
Arg.sup.34Lys.sup.27,26-bis-(Glut-ATet)-GLP-1(7-39);
Gly.sup.8Lys.sup.26,34-bis-(Glut-ATet)-GLP-1(7-36);
Gly.sup.8Lys.sup.26,34-bis-(Glut-ATet)-GLP-1(7-37)
Gly.sup.8Lys.sup.26,34-bis-(Glut-ATet)-GLP-1(7-38);
Gly.sup.8Lys.sup.26,34-bis-(Glut-ATet)-GLP-1(7-39)
Gly.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glut-ATet)-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glut-ATet)-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glut-ATet)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glut-ATet)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34,37-bis-(Glut-ATet)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26,37-bis-(Glut-ATet)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34,38-bis-(Glut-ATet)-GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.26,38-bis-(Glut-ATet)-GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Glut-ATet)-GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.34,39-bis-(Glut-ATet)-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.26,39-bis-(Glut-ATet)-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Glut-ATet)-GLP-1(7-39);
[1178] Val.sup.8Lys.sup.26,34-bis-(Glut-ATet)-GLP-1(7-36);
Val.sup.8Lys.sup.26,34-bis-(Glut-ATet)-GLP-1(7-37);
Val.sup.8Lys.sup.26,34-bis-(Glut-ATet)-GLP-1(7-38);
Val.sup.8Lys.sup.26,34-bis-(Glut-ATet)-GLP-1(7-39)
Val.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glut-ATet)-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glut-ATet)-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glut-ATet)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glut-ATet)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34,37-bis-(Glut-ATet)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26,37-bis-(Glut-ATet)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34,38-bis-(Glut-ATet)-GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.26,38-bis-(Glut-ATet)-GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Glut-ATet)-GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.34,39-bis-(Glut-ATet)-GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.26,39-bis-(Glut-ATet)-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Glut-ATet)-GLP-1(7-39);
Ser.sup.8Lys.sup.26,34-bis-(Glut-ATet)-GLP-1(7-36);
Ser.sup.8Lys.sup.26,34-bis-(Glut-ATet)-GLP-1(7-37);
Ser.sup.8Lys.sup.26,34-bis-(Glut-ATet)-GLP-1(7-38);
Ser.sup.8Lys.sup.26,34-bis-(Glut-ATet)-GLP-1(7-39)
Ser.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glut-ATet)-GLP-1(7-36);
Ser.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glut-ATet)-GLP-1(7-36);
Ser.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glut-ATet)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glut-ATet)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34,37-bis-(Glut-ATet)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26,37-bis-(Glut-ATet)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34,38-bis-(Glut-ATet)-GLP-1(7-38);
Ser.sup.8Arg.sup.34Lys.sup.26,38-bis-(Glut-ATet)-GLP-1(7-38);
Ser.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Glut-ATet)-GLP-1(7-38);
Ser.sup.8Arg.sup.26Lys.sup.34,39-bis-(Glut-ATet)-GLP-1(7-39);
Ser.sup.8Arg.sup.34Lys.sup.26,39-bis-(Glut-ATet)-GLP-1(7-39);
Ser.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Glut-ATet)-GLP-1(7-39);
Thr.sup.8Lys.sup.26,34-bis-(Glut-ATet)-GLP-1(7-36);
Thr.sup.8Lys.sup.26,34-bis-(Glut-ATet)-GLP-1(7-37);
Thr.sup.8Lys.sup.26,34-bis-(Glut-ATet)-GLP-1(7-38);
Thr.sup.8Lys.sup.26,34-bis-(Glut-ATet)-GLP-1(7-39)
Thr.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glut-ATet)-GLP-1(7-36);
Thr.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glut-ATet)-GLP-1(7-36);
Thr.sup.8Arg.sup.26Lys.sup.34,36-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glut-ATet)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34,37-bis-(Glut-ATet)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26,37-bis-(Glut-ATet)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34,38-bis-(Glut-ATet)-GLP-1(7-38);
Thr.sup.8Arg.sup.34Lys.sup.26,38-bis-(Glut-ATet)-GLP-1(7-38);
Thr.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Glut-ATet)-GLP-1(7-38);
Thr.sup.8Arg.sup.26Lys.sup.34,39-bis-(Glut-ATet)-GLP-1(7-39);
Thr.sup.8Arg.sup.34Lys.sup.26,39-bis-(Glut-ATet)-GLP-1(7-39);
Thr.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Glut-ATet)-GLP-1(7-39);
Lys.sup.26,34-bis-(Glut-AHex)-GLP-1(7-36);
Lys.sup.26,34-bis-(Glut-AHex)-GLP-1(7-37);
Lys.sup.26,34-bis-(Glut-AHex)-GLP-1(7-38);
Lys.sup.26,34-bis-(Glut-AHex)-GLP-1(7-39)
Arg.sup.26Lys.sup.34,36-bis-(Glut-AHex)-GLP-1(7-36);
Arg.sup.34Lys.sup.26,36-bis-(Glut-AHex)-GLP-1(7-36);
Arg.sup.26Lys.sup.34,36-bis-(Glut-AHex)-GLP-1(7-37);
Arg.sup.34Lys.sup.26,36-bis-(Glut-AHex)-GLP-1(7-37)
Arg.sup.26Lys.sup.34,37-bis-(Glut-AHex)-GLP-1(7-37);
Arg.sup.34Lys.sup.26,37-bis-(Glut-AHex)-GLP-1(7-37);
Arg.sup.26Lys.sup.34,39-bis-(Glut-AHex)-GLP-1(7-39);
Arg.sup.34Lys.sup.26,39-bis-(Glut-AHex)-GLP-1(7-39);
Arg.sup.26,34Lys.sup.34,39-bis-(Glut-AHex)-GLP-1(7-39);
[1179] Arg.sup.26Lys.sup.18,34-bis-(Glut-AHex)-GLP-1(7-36);
Arg.sup.34Lys.sup.18,26-bis-(Glut-AHex)-GLP-1(7-36);
Arg.sup.26Lys.sup.18,34-bis-(Glut-AHex)-GLP-1(7-37);
Arg.sup.34Lys.sup.18,26-bis-(Glut-AHex)-GLP-1(7-37);
Arg.sup.26Lys.sup.18,34-bis-(Glut-AHex)-GLP-1(7-38);
Arg.sup.34Lys.sup.18,26-bis-(Glut-AHex)-GLP-1(7-38);
Arg.sup.26Lys.sup.18,34-bis-(Glut-AHex)-GLP-1(7-39);
Arg.sup.34Lys.sup.18,26-bis-(Glut-AHex)-GLP-1(7-39);
Arg.sup.26Lys.sup.23,34-bis-(Glut-AHex)-GLP-1(7-36);
Arg.sup.34Lys.sup.23,26-bis-(Glut-AHex)-GLP-1(7-36);
Arg.sup.26Lys.sup.23,34-bis-(Glut-AHex)-GLP-1(7-37);
Arg.sup.34Lys.sup.23,26-bis-(Glut-AHex)-GLP-1(7-37);
Arg.sup.26Lys.sup.23,34-bis-(Glut-AHex)-GLP-1(7-38);
Arg.sup.34Lys.sup.23,26-bis-(Glut-AHex)-GLP-1(7-38);
Arg.sup.26Lys.sup.23,34-bis-(Glut-AHex)-GLP-1(7-39);
Arg.sup.34Lys.sup.23,26-bis-(Glut-AHex)-GLP-1(7-39);
Arg.sup.26Lys.sup.27,34-bis-(Glut-AHex)-GLP-1(7-36);
Arg.sup.34Lys.sup.27,26-bis-(Glut-AHex)-GLP-1(7-36);
Arg.sup.26Lys.sup.27,34-bis-(Glut-AHex)-GLP-1(7-37);
Arg.sup.34Lys.sup.27,26-bis-(Glut-AHex)-GLP-1(7-37);
Arg.sup.26Lys.sup.27,34-bis-(Glut-AHex)-GLP-1(7-38);
Arg.sup.34Lys.sup.27,26-bis-(Glut-AHex)-GLP-1(7-38);
Arg.sup.26Lys.sup.27,34-bis-(Glut-AHex)-GLP-1(7-39);
Arg.sup.34Lys.sup.27,26-bis-(Glut-AHex)-GLP-1(7-39);
Gly.sup.8Lys.sup.26,34-bis-(Glut-AHex)-GLP-1(7-36);
Gly.sup.8Lys.sup.26,34-bis-(Glut-Alex)-GLP-1(7-37);
Gly.sup.8Lys.sup.26,34-bis-(Glut-AHex)-GLP-1(7-38);
Gly.sup.8Lys.sup.26,34-bis-(Glut-AHex)-GLP-1(7-39)
Gly.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glut-AHex)-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glut-AHex)-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glut-AHex)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glut-AHex)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34,37-bis-(Glut-AHex)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26,37-bis-(Glut-AHex)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34,38-bis-(Glut-AHex)-GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.26,38-bis-(Glut-AHex)-GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Glut-AHex)-GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.34,39-bis-(Glut-AHex)-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.26,39-bis-(Glut-AHex)-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Glut-AHex)-GLP-1(7-39);
[1180] Val.sup.8Lys.sup.26,34-bis-(Glut-AHex)-GLP-1(7-36);
Val.sup.8Lys.sup.26,34-bis-(Glut-AHex)-GLP-1(7-37);
Val.sup.8Lys.sup.26,34-bis-(Glut-AHex)-GLP-1(7-38);
Val.sup.8Lys.sup.26,34-bis-(Glut-AHex)-GLP-1(7-39)
Val.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glut-AHex)-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glut-AHex)-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glut-AHex)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glut-AHex)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34,37-bis-(Glut-AHex)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26,37-bis-(Glut-A-Hex)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34,38-bis-(Glut-AHex)-GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.26,38-bis-(Glut-AHex)-GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Glut-AHex)-GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.34,39-bis-(Glut-AHex)-GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.26,39-bis-(Glut-AHex)-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Glut-AHex)-GLP-1(7-39);
[1181] Ser.sup.8Lys.sup.26,34-bis-(Glut-AHex)-GLP-1(7-36);
Ser.sup.8Lys.sup.26,34-bis-(Glut-AHex)-GLP-1(7-37);
Ser.sup.8Lys.sup.26,34-bis-(Glut-AHex)-GLP-1(7-38);
Ser.sup.8Lys.sup.26,34-bis-(Glut-AHex)-GLP-1(7-39)
Ser.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glut-AHex)-GLP-1(7-36);
Ser.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glut-AHex)-GLP-1(7-36);
Ser.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glut-AHex)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glut-AHex)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34,37-bis-(Glut-AHex)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26,37-bis-(Glut-AHex)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34,38-bis-(Glut-AHex)-GLP-1(7-38);
Ser.sup.8Arg.sup.34Lys.sup.26,38-bis-(Glut-AHex)-GLP-1(7-38);
Ser.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Glut-AHex)-GLP-1(7-38);
Ser.sup.8Arg.sup.26Lys.sup.34,39-bis-(Glut-AHex)-GLP-1(7-39);
Ser.sup.8Arg.sup.34Lys.sup.26,39-bis-(Glut-AHex)-GLP-1(7-39);
Ser.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Glut-AHex)-GLP-1(7-39);
[1182] Thr.sup.8Lys.sup.26,34-bis-(Glut-AHex)-GLP-1(7-36);
Thr.sup.8Lys.sup.26,34-bis-(Glut-AHex)-GLP-1(7-37);
Thr.sup.8Lys.sup.26,34-bis-(Glut-AHex)-GLP-1(7-38);
Thr.sup.8Lys.sup.26,34-bis-(Glut-AHex)-GLP-1(7-39)
Thr.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glut-AHex)-GLP-1(7-36);
Thr.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glut-AHex)-GLP-1(7-36);
Thr.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glut-AHex)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glut-AHex)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34,37-bis-(Glut-AHex)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26,37-bis-(Glut-AHex)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34,38-bis-(Glut-AHex)-GLP-1(7-38);
Thr.sup.8Arg.sup.34Lys.sup.26,38-bis-(Glut-AHex)-GLP-1(7-38);
Thr.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Glut-AHex)-GLP-1(7-38);
Thr.sup.8Arg.sup.26Lys.sup.34,39-bis-(Glut-AHex)-GLP-1(7-39);
Thr.sup.8Arg.sup.34Lys.sup.26,39-bis-(Glut-AHex)-GLP-1(7-39);
Thr.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Glut-AHex)-GLP-1(7-39);
[1183] Lys.sup.26,34-bis-(Glut-AOct)-GLP-1(7-36);
Lys.sup.26,34-bis-(Glut-AOct)-GLP-1(7-37);
Lys.sup.26,34-bis-(Glut-AOct)-GLP-1(7-38);
Lys.sup.26,34-bis-(Glut-AOct)-GLP-1(7-39)
Arg.sup.26Lys.sup.34,36-bis-(Glut-AOct)-GLP-1(7-36);
Arg.sup.34Lys.sup.26,36-bis-(Glut-AOct)-GLP-1(7-36);
Arg.sup.26Lys.sup.34,36-bis-(Glut-AOct)-GLP-1(7-37);
Arg.sup.34Lys.sup.26,36-bis-(Glut-AOct)-GLP-1(7-37);
Arg.sup.26Lys.sup.34,37-bis-(Glut-AOct)-GLP-1(7-37);
Arg.sup.34Lys.sup.26,37-bis-(Glut-AOct)-GLP-1(7-37);
Arg.sup.26Lys.sup.34,39-bis-(Glut-AOct)-GLP-1(7-39);
Arg.sup.34Lys.sup.26,39-bis-(Glut-AOct)-GLP-1(7-39);
Arg.sup.26,34Lys.sup.36,39-bis-(Glut-AOct)-GLP-1(7-39);
[1184] Arg.sup.26Lys.sup.18,34-bis-(Glut-AOct)-GLP-1(7-36);
Arg.sup.34Lys.sup.18,26-bis-(Glut-AOct)-GLP-1(7-36);
Arg.sup.26Lys.sup.18,34-bis-(Glut-AOct)-GLP-1(7-37);
Arg.sup.34Lys.sup.18,26-bis-(Glut-AOct)-GLP-1(7-37);
Arg.sup.26Lys.sup.18,34-bis-(Glut-AOct)-GLP-1(7-38);
Arg.sup.34Lys.sup.18,26-bis-(Glut-AOct)-GLP-1(7-38);
Arg.sup.26Lys.sup.18,34-bis-(Glut-AOct)-GLP-1(7-39);
Arg.sup.34Lys.sup.18,26-bis-(Glut-AOct)-GLP-1(7-39);
Arg.sup.26Lys.sup.23,34-bis-(Glut-AOct)-GLP-1(7-36);
Arg.sup.34Lys.sup.23,26-bis-(Glut-AOct)-GLP-1(7-36);
Arg.sup.26Lys.sup.23,34-bis-(Glut-AOct)-GLP-1(7-37);
Arg.sup.34Lys.sup.23,26-bis-(Glut-AOct)-GLP-1(7-37);
Arg.sup.26Lys.sup.23,34-bis-(Glut-AOct)-GLP-1(7-38);
Arg.sup.34Lys.sup.23,26-bis-(Glut-AOct)-GLP-1(7-38);
Arg.sup.26Lys.sup.23,34-bis-(Glut-AOct)-GLP-1(7-39);
Arg.sup.34Lys.sup.23,26-bis-(Glut-AOct)-GLP-1(7-39);
Arg.sup.26Lys.sup.27,34-bis-(Glut-AOct)-GLP-1(7-36);
Arg.sup.34Lys.sup.27,26-bis-(Glut-AOct)-GLP-1(7-36);
Arg.sup.26Lys.sup.27,34-bis-(Glut-AOct)-GLP-1(7-37);
Arg.sup.34Lys.sup.27,26-bis-(Glut-AOct)-GLP-1(7-37);
Arg.sup.26Lys.sup.27,34-bis-(Glut-AOct)-GLP-1(7-38);
Arg.sup.34Lys.sup.27,26-bis-(Glut-AOct)-GLP-1(7-38);
Arg.sup.26Lys.sup.27,34-bis-(Glut-AOct)-GLP-1(7-39);
Arg.sup.34Lys.sup.27,26-bis-(Glut-AOct)-GLP-1(7-39);
Gly.sup.8Lys.sup.26,34-bis-(Glut-AOct)-GLP-1(7-36);
Gly.sup.8Lys.sup.26,34-bis-(Glut-AOct)-GLP-1(7-37);
Gly.sup.8Lys.sup.26,34-bis-(Glut-AOct)-GLP-1(7-38);
Gly.sup.8Lys.sup.26,34-bis-(Glut-AOct)-GLP-1(7-39)
Gly.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glut-AOct)-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glut-AOct)-GLP-1(7-36)
Gly.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glut-AOct)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glut-AOct)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34,37-bis-(Glut-AOct)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26,37-bis-(Glut-AOct)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34,38-bis-(Glut-AOct)-GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.26,38-bis-(Glut-AOct)-GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Glut-AOct)-GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glut-AOct)-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.26,39-bis-(Glut-AOct)-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Glut-AOct)-GLP-1(7-39);
[1185] Val.sup.8Lys.sup.26,34-bis-(Glut-AOct)-GLP-1(7-36);
Val.sup.8Lys.sup.26,34-bis-(Glut-AOct)-GLP-1(7-37);
Val.sup.8Lys.sup.26,34-bis-(Glut-AOct)-GLP-1(7-38);
Val.sup.8Lys.sup.26,34-bis-(Glut-AOct)-GLP-1(7-39)
Val.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glut-AOct)-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glut-AOct)-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glut-AOct)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glut-AOct)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34,37-bis-(Glut-AOct)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26,37-bis-(Glut-AOct)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34,38-bis-(Glut-AOct)-GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.26,38-bis-(Glut-AOct)-GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Glut-AOct)-GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.34,39-bis-(Glut-AOct)-GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.26,39-bis-(Glut-AOct)-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Glut-AOct)-GLP-1(7-39);
[1186] Ser.sup.8Lys.sup.26,34-bis-(Glut-AOct)-GLP-1(7-36);
Ser.sup.8Lys.sup.26,34-bis-(Glut-AOct)-GLP-1(7-37);
Ser.sup.8Lys.sup.26,34-bis-(Glut-AOct)-GLP-1(7-38);
Ser.sup.8Lys.sup.26,34-bis-(Glut-AOct)-GLP-1(7-39)
Ser.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glut-AOct)-GLP-1(7-36);
Ser.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glut-AOct)-GLP-1(7-36);
Ser.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glut-AOct)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glut-AOct)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34,37-bis-(Glut-AOct)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26,37-bis-(Glut-AOct)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34,38-bis-(Glut-AOct)-GLP-1(7-38);
Ser.sup.8Arg.sup.34Lys.sup.26,38-bis-(Glut-AOct)-GLP-1(7-38);
Ser.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Glut-AOct)-GLP-1(7-38);
Ser.sup.8Arg.sup.26Lys.sup.34,39-bis-(Glut-AOct)-GLP-1(7-39);
Ser.sup.8Arg.sup.34Lys.sup.26,39-bis-(Glut-AOct)-GLP-1(7-39);
Ser.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Glut-AOct)-GLP-1(7-39);
Thr.sup.8Lys.sup.26,34-bis-(Glut-AOct)-GLP-1(7-36);
Thr.sup.8Lys.sup.26,34-bis-(Glut-AOct)-GLP-1(7-37);
Thr.sup.8Lys.sup.26,34-bis-(Glut-AOct)-GLP-1(7-38);
Thr.sup.8Lys.sup.26,34-bis-(Glut-AOct)-GLP-1(7-39)
Thr.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glut-AOct)-GLP-1(7-36);
Thr.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glut-AOct)-GLP-1(7-36);
Thr.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glut-AOct)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glut-AOct)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34,37-bis-(Glut-AOct)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26,37-bis-(Glut-AOct)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34,38-bis-(Glut-AOct)-GLP-1(7-38);
Thr.sup.8Arg.sup.34Lys.sup.26,38-bis-(Glut-AOct)-GLP-1(7-38);
Thr.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Glut-AOct)-GLP-1(7-38);
Thr.sup.8Arg.sup.26Lys.sup.34,39-bis-(Glut-AOct)-GLP-1(7-39);
Thr.sup.8Arg.sup.34Lys.sup.26,39-bis-(Glut-AOct)-GLP-1(7-39);
Thr.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Glut-A
Oct)-GLP-1(7-39);
[1187] Lys.sup.26,34-bis-(Glut-ALit)-GLP-1(7-36);
Lys.sup.26,34-bis-(Glut-ALit)-GLP-1(7-37);
Lys.sup.26,34-bis-(Glut-ALit)-GLP-1(7-38);
Lys.sup.26,34-bis-(Glut-ALit)-GLP-1(7-39)
Arg.sup.26Lys.sup.34,36-bis-(Glut-ALit)-GLP-1(7-36);
Arg.sup.34Lys.sup.26,36-bis-(Glut-ALit)-GLP-1(7-36);
Arg.sup.26Lys.sup.34,36-bis-(Glut-ALit)-GLP-1(7-37);
Arg.sup.34Lys.sup.26,36-bis-(Glut-ALit)-GLP-1(7-37);
Arg.sup.26Lys.sup.34,37-bis-(Glut-ALit)-GLP-1(7-37);
Arg.sup.34Lys.sup.26,37-bis-(Glut-ALit)-GLP-1(7-37);
Arg.sup.26Lys.sup.34,39-bis-(Glut-ALit)-GLP-1(7-39);
Arg.sup.34Lys.sup.26,39-bis-(Glut-ALit)-GLP-1(7-39);
Arg.sup.26,34Lys.sup.36,39-bis-(Glut-ALit)-GLP-1(7-39);
[1188] Arg.sup.26Lys.sup.18,34-bis-(Glut-ALit)-GLP-1(7-36);
Arg.sup.34Lys.sup.18,26-bis-(Glut-ALit)-GLP-1(7-36);
Arg.sup.26Lys.sup.18,34-bis-(Glut-ALit)-GLP-1(7-37);
Arg.sup.34Lys.sup.18,26-bis-(Glut-ALit)-GLP-1(7-37);
Arg.sup.26Lys.sup.18,34-bis-(Glut-ALit)-GLP-1(7-38);
Arg.sup.34Lys.sup.18,26-bis-(Glut-ALit)-GLP-1(7-38);
Arg.sup.26Lys.sup.18,34-bis-(Glut-ALit)-GLP-1(7-39);
Arg.sup.34Lys.sup.18,26-bis-(Glut-ALit)-GLP-1(7-39);
Arg.sup.26Lys.sup.18,34-bis-(Glut-ALit)-GLP-1(7-39);
Arg.sup.34Lys.sup.18,26-bis-(Glut-ALit)-GLP-1(7-39);
Arg.sup.26Lys.sup.23,34-bis-(Glut-ALit)-GLP-1(7-36);
Arg.sup.34Lys.sup.23,26-bis-(Glut-ALit)-GLP-1(7-36);
Arg.sup.26Lys.sup.23,34-bis-(Glut-ALit)-GLP-1(7-37);
Arg.sup.34Lys.sup.23,26-bis-(Glut-ALit)-GLP-1(7-37);
Arg.sup.26Lys.sup.23,34-bis-(Glut-ALit)-GLP-1(7-38);
Arg.sup.34Lys.sup.23,26-bis-(Glut-ALit)-GLP-1(7-38);
Arg.sup.26Lys.sup.23,34-bis-(Glut-ALit)-GLP-1(7-39);
Arg.sup.34Lys.sup.23,26-bis-(Glut-ALit)-GLP-1(7-39);
Arg.sup.26Lys.sup.27,34-bis-(Glut-ALit)-GLP-1(7-36);
Arg.sup.34Lys.sup.27,26-bis-(Glut-ALit)-GLP-1(7-36);
Arg.sup.26Lys.sup.27,34-bis-(Glut-ALit)-GLP-1(7-37);
Arg.sup.34Lys.sup.27,26-bis-(Glut-ALit)-GLP-1(7-37);
Arg.sup.26Lys.sup.27,34-bis-(Glut-ALit)-GLP-1(7-38);
Arg.sup.34Lys.sup.27,26-bis-(Glut-ALit)-GLP-1(7-38);
Arg.sup.26Lys.sup.27,34-bis-(Glut-ALit)-GLP-1(7-39);
Arg.sup.34Lys.sup.27,26-bis-(Glut-ALit)-GLP-1(7-39);
Gly.sup.8Lys.sup.26,34-bis-(Glut-ALit)-GLP-1(7-36);
Gly.sup.8Arg.sup.26,34-bis-(Glut-ALit)-GLP-1(7-37);
Gly.sup.8Lys.sup.26,34-bis-(Glut-ALit)-GLP-1(7-38);
Gly.sup.8Lys.sup.26,34-bis-(Glut-ALit)-GLP-1(7-39)
Gly.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glut-ALit)-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glut-ALit)-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glut-ALit)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glut-ALit)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34,37-bis-(Glut-ALit)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26,37-bis-(Glut-ALit)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34,38-bis-(Glut-ALit)-GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.26,38-bis-(Glut-ALit)-GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.34,38-bis-(Glut-ALit)-GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.34,39-bis-(Glut-ALit)-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.26,39-bis-(Glut-ALit)-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Glut-ALit)-GLP-1(7-39);
Val.sup.8Lys.sup.26,34-bis-(Glut-ALit)-GLP-1(7-36);
Val.sup.8Lys.sup.26,34-bis-(Glut-ALit)-1(7-37);
Val.sup.8Lys.sup.26,34-bis-(Glut-ALit)-GLP-1(7-38);
Val.sup.8Lys.sup.26,34-bis-(Glut-ALit)-GLP-1(7-39)
Val.sup.8Arg.sup.26 Lys.sup.34,36-bis-(Glut-ALit)-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glut-ALit)-GLP-1(7-36);
Val.sup.8Arg.sup.26 Lys.sup.34,36-bis-(Glut-ALit)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glut-ALit)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34,37-bis-(Glut-ALit)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26,37-bis-(Glut-ALit)-GLP-1(7-37);
Val.sup.8Arg.sup.34,38-bis-(Glut-ALit)-GLP-1(7-38);
Val.sup.87Arg.sup.34Lys.sup.26,38-bis-(Glut-ALit)-GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.26,39-bis-(Glut-ALit)-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Glut-ALit)-GLP-1(7-39);
Ser.sup.8Lys.sup.26,34-bis-(Glut-ALit)-GLP-1(7-36);
Ser.sup.8Lys.sup.26,34-bis-(Glut-ALit)-GLP-1(7-37);
Ser.sup.8Lys.sup.26,34-bis-(Glut-ALit)-GLP-1(7-38);
Ser.sup.8Lys.sup.26,34-bis-(Glut-ALit)-GLP-1(7-39)
Ser.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glut-ALit)-GLP-1(7-36);
Ser.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glut-ALit)-GLP-1(7-36);
Ser.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glut-ALit)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glut-ALit)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34,37-bis-(Glut-ALit)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26,37-bis-(Glut-ALit)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34,38-bis-(Glut-ALit)-GLP-1(7-38);
Ser.sup.8Arg.sup.34Lys.sup.26,38-bis-(Glut-ALit)-GLP-1(7-38);
Ser.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Glut-ALit)-GLP-1(7-38);
Ser.sup.8Arg.sup.26Lys.sup.34,39-bis-(Glut-ALit)-GLP-1(7-39);
Ser.sup.8Arg.sup.34Lys.sup.26,39-bis-(Glut-ALit)-GLP-1(7-39);
Ser.sup.8Arg.sup.26,34 Lys.sup.36,39-bis-(Glut-ALit)-GLP-1(7-39);
Thr.sup.8Lys.sup.26,34-bis-(Glut-ALit)-GLP-1(7-36);
Thr.sup.8Lys.sup.26,34-bis-(Glut-ALit)-GLP-1(7-37);
Thr.sup.8Lys.sup.26,34-bis-(Glut-ALit)-GLP-1(7-38);
Thr.sup.8Lys.sup.26,34-bis-(Glut-ALit)-GLP-1(7-39)
Thr.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glut-ALit)-GLP-1(7-36);
Thr.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glut-ALit)-GLP-1(7-36);
Thr.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glut-ALit)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glut-ALit)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34,37-bis-(Glut-ALit)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26,37-bis-(Glut-ALit)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34,38-bis-(Glut-ALit)-GLP-1(7-38);
Thr.sup.8Arg.sup.34Lys.sup.26,38-bis-(Glut-ALit)-GLP-1(7-38);
Thr.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Glut-ALit)-GLP-1(7-38);
Thr.sup.8Arg.sup.26Lys.sup.34,39-bis-(Glut-ALit)-GLP-1(7-39);
Thr.sup.8Arg.sup.34Lys.sup.26,39-bis-(Glut-ALit)-GLP-1(7-39);
Thr.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Glut-ALit)-GLP-1(7-39);
Lys.sup.26,34-bis-(Aspa-ADod)-GLP-1(7-36);
Lys.sup.26,34-bis-(Aspa-ADod)-GLP-1(7-37);
Lys.sup.26,34-bis-(Aspa-ADod)-GLP-1(7-38);
Lys.sup.26,34-bis-(Aspa-ADod)-GLP-1(7-39)
Arg.sup.26Lys.sup.34,36-bis-(Asp-ADod)-GLP-1(7-36);
Arg.sup.34Lys.sup.26,36-bis-(Aspa-ADod)-GLP-1(7-36);
Arg.sup.26Lys.sup.34,36-bis-(Aspa-ADod)-GLP-1(7-37);
Arg.sup.34Lys.sup.26,36-bis-(Aspa-ADod)-GLP-1(7-37);
Arg.sup.26Lys.sup.34,37-bis-(Aspa-ADod)-GLP-1(7-37);
Arg.sup.34Lys.sup.26,37-bis-(Aspa-ADod)-GLP-1(7-37);
Arg.sup.26Lys.sup.34,39-bis-(Aspa-ADod)-GLP-1(7-39);
Arg.sup.34Lys.sup.26,39-bis-(Aspa-ADod)-GLP-1(7-39);
Arg.sup.26,34Lys.sup.36,39-bis-(Aspa-ADod)-GLP-1(7-39);
Arg.sup.26Lys.sup.18,34-bis-(Aspa-ADod)-GLP-1(7-36);
Arg.sup.34Lys.sup.18,26-bis-(Aspa-ADod)-GLP-1(7-36);
Arg.sup.26Lys.sup.18,34-bis-(Aspa-ADod)-GLP-1(7-37);
Arg.sup.34Lys.sup.18,26-bis-(Aspa-ADod)-GLP-1(7-37);
Arg.sup.26Lys.sup.18,34-bis-(Aspa-ADod)-GLP-1(7-38);
Arg.sup.34Lys.sup.18,26-bis-(Aspa-ADod)-GLP-1(7-38);
Arg.sup.26Lys.sup.18,34-bis-(Aspa-ADod)-GLP-1(7-39);
Arg.sup.34Lys.sup.18,26-bis-(Aspa-ADod)-GLP-1(7-39);
Arg.sup.26Lys.sup.23,34-bis-(Aspa-ADod)-GLP-1(7-36);
Arg.sup.34Lys.sup.23,26-bis-(Aspa-ADod)-GLP-1(7-36);
Arg.sup.26Lys.sup.23,34-bis-(Aspa-ADod)-GLP-1(7-37);
Arg.sup.34Lys.sup.23,26-bis-(Aspa-ADod)-GLP-1(7-37);
Arg.sup.26Lys.sup.23,34-bis-(Aspa-ADod)-GLP-1(7-38);
Arg.sup.34Lys.sup.23,26-bis-(Aspa-ADod)-GLP-1(7-38);
Arg.sup.26Lys.sup.23,34-bis-(Aspa-ADod)-GLP-1(7-39);
Arg.sup.34Lys.sup.23,26-bis-(Aspa-ADod)-GLP-1(7-39);
Arg.sup.26Lys.sup.27,34-bis-(Aspa-ADod)-GLP-1(7-36);
Arg.sup.34Lys.sup.27,26-bis-(Aspa-ADod)-GLP-1(7-36);
Arg.sup.26Lys.sup.27,34-bis-(Aspa-ADod)-GLP-1(7-37);
Arg.sup.34Lys.sup.27,26-bis-(Aspa-ADod)-GLP-1(7-37);
Arg.sup.26Lys.sup.27,34-bis-(Aspa-ADod)-GLP-1(7-38);
Arg.sup.34Lys.sup.27,26-bis-(Aspa-ADod)-GLP-1(7-38);
Arg.sup.26Lys.sup.27,34-bis-(Aspa-ADod)-GLP-1(7-39);
Arg.sup.34Lys.sup.27,26-bis-(Aspa-ADod)-GLP-1(7-39);
Gly.sup.8Lys.sup.26,34-bis-(Aspa-ADod)-GLP-1(7-36);
Gly.sup.8Lys.sup.26,34-bis-(Aspa-ADod)-GLP-1(7-37);
Gly.sup.8Lys.sup.26,34-bis-(Aspa-ADod)-GLP-1(7-38);
Gly.sup.8Lys.sup.26,34-bis-(Aspa-ADod)-GLP-1(7-39)
Gly.sup.8Arg.sup.26Lys.sup.34,36-bis-(Aspa-ADod)-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.26,36-bis-(Aspa-ADod)-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.34,36-bis-(Aspa-ADod)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26,36-bis-(Aspa-ADod)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34,37-bis-(Aspa-ADod)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26,37-bis-(Aspa-ADod)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34,38-bis-(Aspa-ADod)-GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.26,38-bis-(Aspa-ADod)-GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Aspa-ADod)-GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.34,39-bis-(Aspa-ADod)-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.26,39-bis-(Aspa-ADod)-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Aspa-ADod)-GLP-1(7-39);
[1189] Val.sup.8Lys.sup.26,34-bis-(Aspa-ADod)-GLP-1(7-36);
Val.sup.8Lys.sup.26,34-bis-(Aspa-ADod)-GLP-1(7-37);
Val.sup.8Lys.sup.26,34-bis-(Aspa-ADod)-GLP-1(7-38);
Val.sup.8Lys.sup.26,34-bis-(Aspa-ADod)-GLP-1(7-39)
Val.sup.8Arg.sup.26Lys.sup.34,36-bis-(Aspa-ADod)-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.26,36-bis-(Aspa-ADod)-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.34,36-bis-(Aspa-ADod)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26,36-bis-(Aspa-ADod)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34,37-bis-(Aspa-ADod)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26,37-bis-(Aspa-ADod)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34,38-bis-(Aspa-ADod)-GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.26,38-bis-(Aspa-ADod)-GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Aspa-ADod)-GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.34,39-bis-(Aspa-ADod)-GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.26,39-bis-(Aspa-ADod)-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Aspa-ADod)-GLP-1(7-39);
[1190] Ser.sup.8Lys.sup.26,34-bis-(Aspa-ADod)-GLP-1(7-36);
Ser.sup.8Lys.sup.26,34-bis-(Aspa-ADod)-GLP-1(7-37);
Ser.sup.8Lys.sup.26,34-bis-(Aspa-ADod)-GLP-1(7-38);
Ser.sup.8Lys.sup.26,34-bis-(Aspa-ADod)-GLP-1(7-39)
Ser.sup.8Arg.sup.26Lys.sup.34,36-bis-(Aspa-ADod)-GLP-1(7-36);
Ser.sup.8Arg.sup.34Lys.sup.26,36-bis-(Aspa-ADod)-GLP-1(7-36);
Ser.sup.8Arg.sup.26Lys.sup.34,36-bis-(Aspa-ADod)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26,36-bis-(Aspa-ADod)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34,37-bis-(Aspa-ADod)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26,37-bis-(Aspa-ADod)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34,38-bis-(Aspa-ADod)-GLP-1(7-38);
Ser.sup.8Arg.sup.34Lys.sup.26,38-bis-(Aspa-ADod)-GLP-1(7-38);
Ser.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Aspa-ADod)-GLP-1(7-38);
Ser.sup.8Arg.sup.26Lys.sup.34,39-bis-(Aspa-ADod)-GLP-1(7-39);
Ser.sup.8Arg.sup.34Lys.sup.26,39-bis-(Aspa-ADod)-GLP-1(7-39);
Ser.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Aspa-ADod)-GLP-1(7-39);
[1191] Thr.sup.8Lys.sup.26,34-bis-(Aspa-ADod)-GLP-1(7-36);
Thr.sup.8Lys.sup.26,34-bis-(Aspa-ADod)-GLP-1(7-37);
Thr.sup.8Lys.sup.26,34-bis-(Aspa-ADod)-GLP-1(7-38);
Thr.sup.8Lys.sup.26,34-bis-(Aspa-ADod)-GLP-1(7-39)
Thr.sup.8Arg.sup.26Lys.sup.34,36-bis-(Aspa-ADod)-GLP-1(7-36);
Thr.sup.8Arg.sup.34Lys.sup.26,36-bis-(Aspa-ADod)-GLP-1(7-36);
Thr.sup.8Arg.sup.26Lys.sup.34,36-bis-(Aspa-ADod)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26,36-bis-(Aspa-ADod)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34,37-bis-(Aspa-ADod)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26,37-bis-(Aspa-ADod)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34,38-bis-(Aspa-ADod)-GLP-1(7-38);
Thr.sup.8Arg.sup.34Lys.sup.26,38-bis-(Aspa-ADod)-GLP-1(7-38);
Thr.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Aspa-ADod)-GLP-1(7-38);
Thr.sup.8Arg.sup.26Lys.sup.34,39-bis-(Aspa-ADod)-GLP-1(7-39);
Thr.sup.8Arg.sup.34Lys.sup.26,39-bis-(Aspa-ADod)-GLP-1(7-39);
Thr.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Aspa-ADod)-GLP-1(7-39);
[1192] Lys.sup.26,34-bis-(Aspa-ATet)-GLP-1(7-36);
Lys.sup.26,34-bis-(Aspa-ATet)-GLP-1(7-37);
Lys.sup.26,34-bis-(Aspa-ATet)-GLP-1(7-38);
Lys.sup.26,34-bis-(Aspa-ATet)-GLP-1(7-39)
Arg.sup.26Lys.sup.34,36-bis-(Aspa-ATet)-GLP-1(7-36);
Arg.sup.34Lys.sup.26,36-bis-(Aspa-ATet)-GLP-1(7-36);
Arg.sup.26Lys.sup.34,36-bis-(Aspa-ATet)-GLP-1(7-37);
Arg.sup.34Lys.sup.26,36-bis-(Aspa-ATet)-GLP-1(7-37);
Arg.sup.26Lys.sup.34,37-bis-(Aspa-ATet)-GLP-1(7-37);
Arg.sup.34Lys.sup.26,37-bis-(Aspa-ATet)-GLP-1(7-37);
Arg.sup.26Lys.sup.34,39-bis-(Aspa-ATet)-GLP-1(7-39);
Arg.sup.34Lys.sup.26,39-bis-(Aspa-ATet)-GLP-1(7-39);
Arg.sup.26,34Lys.sup.36,39-bis-(Aspa-ATet)-GLP-1(7-39);
[1193] Arg.sup.26Lys.sup.18,34-bis-(Aspa-ATet)-GLP-1(7-36);
Arg.sup.34Lys.sup.18,26-bis-(Aspa-ATet)-GLP-1(7-36);
Arg.sup.26Lys.sup.18,34-bis-(Aspa-ATet)-GLP-1(7-37);
Arg.sup.34Lys.sup.18,26-bis-(Aspa-ATet)-GLP-1(7-37);
Arg.sup.26Lys.sup.18,34-bis-(Aspa-ATet)-GLP-1(7-38);
Arg.sup.34Lys.sup.18,26-bis-(Aspa-ATet)-GLP-1(7-38);
Arg.sup.26Lys.sup.18,34-bis-(Aspa-ATet)-GLP-1(7-39);
Arg.sup.34Lys.sup.18,26-bis-(Aspa-ATet)-GLP-1(7-39);
Arg.sup.26Lys.sup.23,34-bis-(Aspa-ATet)-GLP-1(7-36);
Arg.sup.34Lys.sup.23,26-bis-(Aspa-ATet)-GLP-1(7-36);
Arg.sup.26Lys.sup.23,34-bis-(Aspa-ATet)-GLP-1(7-37);
Arg.sup.34Lys.sup.23,26-bis-(Aspa-ATet)-GLP-1(7-37);
Arg.sup.26Lys.sup.23,34-bis-(Aspa-ATet)-GLP-1(7-38);
Arg.sup.34Lys.sup.23,36-bis-(Aspa-ATet)-GLP-1(7-38);
Arg.sup.26Lys.sup.23,34-bis-(Aspa-ATet)-GLP-1(7-39);
Arg.sup.34Lys.sup.23,26-bis-(Aspa-ATet)-GLP-1(7-39);
Arg.sup.26Lys.sup.27,34-bis-(Aspa-ATet)-GLP-1(7-36);
Arg.sup.34Lys.sup.27,26-bis-(Aspa-ATet)-GLP-1(7-36);
Arg.sup.26Lys.sup.27,34-bis-(Aspa-ATet)-GLP-1(7-37);
Arg.sup.34Lys.sup.27,26-bis-(Aspa-ATet)-GLP-1(7-37);
Arg.sup.26Lys27,34-bis-(Aspa-ATet)-GLP-1(7-38);
Arg.sup.34Lys.sup.27,26-bis-(Aspa-ATet)-GLP-1(7-38);
Arg.sup.26Lys.sup.27,34-bis-(Aspa-ATet)-GLP-1(7-39);
Arg.sup.34Lys.sup.27,26-bis-(Aspa-ATet)-GLP-1(7-39);
Gly.sup.8Lys.sup.26,34 bis-(Aspa-ATet)-GLP-1(7-36);
Gly.sup.8Lys.sup.26,34-bis-(Aspa-ATet)-GLP-1(7-37);
Gly.sup.8Lys.sup.26,34-bis-(Aspa-ATet)-GLP-1(7-38);
Gly.sup.8Lys.sup.26,34-bis-(Aspa-ATet)-GLP-1(7-39)
Gly.sup.8Arg.sup.26Lys.sup.34,36-bis-(Aspa-ATet)-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.26,36-bis-(Aspa-ATet)-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.34,36-bis-(Aspa-ATet)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26,36-bis-(Aspa-ATet)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34,37-bis-(Aspa-ATet)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26,37-bis-(Aspa-ATet)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34,38-bis-(Aspa-ATet)-GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.26,38-bis-(Aspa-ATet)-GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.34,38-bis-(Aspa-ATet)-GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.34,39-bis-(Aspa-ATet)-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.26,39-bis-(Aspa-ATet)-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Aspa-ATet)-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.26,39-bis-(Aspa-ATet)-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Aspa-ATet)-GLP-1(7-39);
[1194] Val.sup.8Lys.sup.26,34-bis-(Aspa-ATet)-GLP-1(7-36);
Val.sup.8Lys.sup.26,34-bis-(Aspa-ATet)-GLP-1(7-37);
Val.sup.8Lys.sup.26,34-bis-(Aspa-ATet)-GLP-1(7-38);
Val.sup.8Lys.sup.26,34-bis-(Aspa-ATet)-GLP-1(7-39)
Val.sup.8Arg.sup.26Lys.sup.34,36-bis-(Aspa-ATet)-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.26,36-bis-(Aspa-ATet)-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.34,36-bis-(Aspa-ATet)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26,36-bis-(Aspa-ATet)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34,37-bis-(Aspa-ATet)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26,37-bis-(Aspa-ATet)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34,38-bis-(Aspa-ATet)-GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.26,38-bis-(Aspa-ATet)-GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Aspa-ATet)-GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.34,39-bis-(Aspa-ATet)-GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.26,39-bis-(Aspa-ATet)-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Aspa-ATet)-GLP
1(7-39);
[1195] Ser.sup.8Lys.sup.26,34-bis-(Aspa-ATet)-GLP-1(7-36);
Ser.sup.8Lys.sup.26,34-bis-(Aspa-ATet)-GLP-1(7-37);
Ser.sup.8Lys.sup.26,34-bis-(Aspa-ATet)-GLP-1(7-38);
Ser.sup.8Lys.sup.26,34-bis-(Aspa-ATet)-GLP-1(7-39)
Ser.sup.8Arg.sup.26Lys.sup.34,36-bis-(Aspa-ATet)-GLP-1(7-36);
Ser.sup.8Arg.sup.34Lys.sup.26,36-bis-(Aspa-ATet)-GLP-1(7-36);
Ser.sup.8Arg.sup.26Lys.sup.34,36-bis-(Aspa-ATet)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26,36-bis-(Aspa-ATet)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34,37-bis-(Aspa-ATet)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26,37-bis-(Aspa-ATet)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34,38-bis-(Aspa-ATet)-GLP-1(7-38);
Ser.sup.8Arg.sup.34Lys.sup.26,38-bis-(Aspa-ATet)-GLP-1(7-38);
Ser.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Aspa-ATet)-GLP-1(7-38);
Ser.sup.8Arg.sup.26Lys.sup.34,39-bis-(Aspa-ATet)-GLP-1(7-39);
Ser.sup.8Arg.sup.34Lys.sup.26,39-bis-(Aspa-ATet)-GLP-1(7-39);
Ser.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Aspa-ATet)-GLP-1(7-39);
[1196] Thr.sup.8Lys.sup.26,34-bis-(Aspa-ATet)-GLP-1(7-36);
Thr.sup.8Lys.sup.26,34-bis-(Aspa-ATet)-GLP-1(7-37);
Thr.sup.8Lys.sup.26,34-bis-(Aspa-ATet)-GLP-1(7-38);
Thr.sup.8Lys.sup.26,34-bis-(Aspa-ATet)-GLP-1(7-39)
Thr.sup.8Arg.sup.26Lys.sup.34,36-bis-(Aspa-ATet)-GLP-1(7-36);
Thr.sup.8Arg.sup.34Lys.sup.26,36-bis-(Aspa-ATet)-GLP-1(7-36);
Thr.sup.8Arg.sup.26Lys.sup.34,36-bis-(Aspa-ATet)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26,36-bis-(Aspa-ATet)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34,37-bis-(Aspa-ATet)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26,37-bis-(Aspa-ATet)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34,38-bis-(Aspa-ATet)-GLP-1(7-38);
Thr.sup.8Arg.sup.34Lys.sup.26,38-bis-(Aspa-ATet)-GLP-1(7-38);
Thr.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Aspa-ATet)-GLP-1(7-38);
Thr.sup.8Arg.sup.26Lys.sup.34,39-bis-(Aspa-ATet)-GLP-1(7-39);
Thr.sup.8Arg.sup.34Lys.sup.26,39-bis-(Aspa-ATet)-GLP-1(7-39);
Thr.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Aspa-ATet)-GLP-1(7-39);
[1197] Lys.sup.26,34-bis-(Aspa-AHex)-GLP-1(7-36);
Lys.sup.26,34-bis-(Aspa-AHex)-GLP-1(7-37);
Lys.sup.26,34-bis-(Aspa-AHex)-GLP-1(7-38);
Lys.sup.26,34-bis-(Aspa-AHex)-GLP-1(7-39)
Arg.sup.26Lys.sup.34,36-bis-(Aspa-AHex)-GLP-1(7-36);
Arg.sup.34Lys.sup.26,36-bis-(Aspa-AHex)-GLP-1(7-36);
Arg.sup.26Lys.sup.34,36-bis-(Aspa-AHex)-GLP-1(7-37);
Arg.sup.34Lys.sup.26,36-bis-(Aspa-AHex)-GLP-1(7-37);
Arg.sup.26Lys.sup.34,37-bis-(Aspa-AHex)-GLP-1(7-37);
Arg.sup.34Lys.sup.26,37-bis-(Aspa-AHex)-GLP-1(7-37);
Arg.sup.26Lys.sup.34,39-bis-(Aspa-AHex)-GLP-1(7-39);
Arg.sup.34Lys.sup.26,39-bis-(Aspa-AHex)-GLP-1(7-39);
Arg.sup.26,34Lys.sup.36,39-bis-(Aspa-AHex)-GLP-1(7-39);
[1198] Arg.sup.26Lys.sup.18,34-bis-(Aspa-AHex)-GLP-1(7-36);
Arg.sup.34Lys.sup.18,26-bis-(Aspa-AHex)-GLP-1(7-36);
Arg.sup.26Lys.sup.18,34-bis-(Aspa-AHex)-GLP-1(7-37);
Arg.sup.34Lys.sup.18,26-bis-(Aspa-AHex)-GLP-1(7-37);
Arg.sup.26Lys.sup.18,34-bis-(Aspa-AHex)-GLP-1(7-38);
Arg.sup.34Lys.sup.18,26-bis-(Aspa-AHex)-GLP-1(7-38);
Arg.sup.26Lys.sup.18,34-bis-(Aspa-AHex)-GLP-1(7-39);
Arg.sup.34Lys.sup.18,26-bis-(Aspa-AHex)-GLP-1(7-39);
Arg.sup.26Lys.sup.23,34-bis-(Aspa-AHex)-GLP-1(7-36);
Arg.sup.34Lys.sup.23,26-bis-(Aspa-AHex)-GLP-1(7-36);
Arg.sup.26Lys.sup.23,34-bis-(Aspa-AHex)-GLP-1(7-37);
Arg.sup.34Lys.sup.23,26-bis-(Aspa-AHex)-GLP-1(7-37);
Arg.sup.26Lys.sup.23,34-bis-(Aspa-AHex)-GLP-1(7-38);
Arg.sup.34Lys.sup.23,26-bis-(Aspa-AHex)-GLP-1(7-38);
Arg.sup.26Lys.sup.23,34-bis-(Aspa-AHex)-GLP-1(7-39);
Arg.sup.34Lys.sup.23,26-bis-(Aspa-AHex)-GLP-1(7-39);
Arg.sup.26Lys.sup.27,34-bis-(Aspa-AHex)-GLP-1(7-36);
Arg.sup.34Lys.sup.27,26-bis-(Aspa-AHex)-GLP-1(7-36);
Arg.sup.26Lys.sup.27,34-bis-(Aspa-AHex)-GLP-1(7-37);
Arg.sup.34Lys.sup.21,26-bis-(Aspa-AHex)-GLP-1(7-37);
Arg.sup.26Lys.sup.27,34-bis-(Aspa-AHex)-GLP-1(7-38);
Arg.sup.34Lys.sup.27,26-bis-(Aspa-AHex)-GLP-1(7-38);
Arg.sup.26Lys.sup.27,34-bis-(Aspa-AHex)-GLP-1(7-39);
Arg.sup.34Lys.sup.27,26-bis-(Aspa-AHex)-GLP-1(7-39);
Gly.sup.8Lys.sup.26,34-bis-(Aspa-AHex)-GLP-1(7-36);
Gly.sup.8Lys.sup.26,34-bis-(Aspa-AHex)-GLP-1(7-37);
Gly.sup.8Lys.sup.26,34-bis-(Aspa-AHex)-GLP-1(7-38);
Gly.sup.8Lys.sup.26,34-bis-(Aspa-AHex)-GLP-1(7-39)
Gly.sup.8Arg.sup.26Lys.sup.34,36-bis-(Aspa-AHex)-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.26,36-bis-(Aspa-AHex)-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.34,36-bis-(Aspa-AHex)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26,36-bis-(Aspa-AHex)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34,37-bis-(Aspa-AHex)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26,37-bis-(Aspa-AHex)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34,38-bis-(Aspa-AHex)-GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.26,38-bis-(Aspa-AHex)-GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Aspa-AHex)-GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.34,39-bis-(Aspa-AHex)-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.26,39-bis-(Aspa-AHex)-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Aspa-AHex)-GLP-1(7-39);
[1199] Val.sup.8Lys.sup.26,34-bis-(Aspa-AHex)-GLP-1(7-36);
Val.sup.8Lys.sup.26,34-bis-(Aspa-AHex)-GLP-1(7-37);
Val.sup.8Lys.sup.26,34-bis-(Aspa-AHex)-GLP-1(7-38);
Val.sup.8Lys.sup.26,34-bis-(Aspa-AHex)-GLP-1(7-39)
Val.sup.8Arg.sup.26Lys.sup.34,36-bis-(Aspa-AHex)-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.26,36-bis-(Aspa-AHex)-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.34,36-bis-(Aspa-AHex)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26,36-bis-(Aspa-AHex)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34,37-bis-(Aspa-AHex)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26,37-bis-(Aspa-AHex)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34,38-bis-(Aspa-AHex)-GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.26,38-bis-(Aspa-AHex)-GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Aspa-AHex)-GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.34,39-bis-(Aspa-AHex)-GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.26,39-bis-(Aspa-AHex)-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Aspa-AHex)-GLP-1(7-39);
[1200] Ser.sup.8Lys.sup.26,34-bis-(Aspa-AHex)-GLP-1(7-36);
Ser.sup.8Lys.sup.26,34-bis-(Aspa-AHex)-GLP-1(7-37);
Ser.sup.8Lys.sup.26,34-bis-(Aspa-AHex)-GLP-1(7-38);
Ser.sup.8Lys.sup.26,34-bis-(Aspa-AHex)-GLP-1(7-39)
Ser.sup.8Arg.sup.26Lys.sup.34,36-bis-(Aspa-AHex)-GLP-1(7-36);
Ser.sup.8Arg.sup.34Lys.sup.26,36-bis-(Aspa-AHex)-GLP-1(7-36);
Ser.sup.8Arg.sup.26Lys.sup.34,36-bis-(Aspa-AHex)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26,36-bis-(Aspa-AHex)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34,37-bis-(Aspa-AHex)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26,37-bis-(Aspa-AHex)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34,38-bis-(Aspa-AHex)-GLP-1(7-38);
Ser.sup.8Arg.sup.34Lys.sup.26,38-bis-(Aspa-AHex)-GLP-1(7-38);
Ser.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Aspa-AHex)-GLP-1(7-38);
Ser.sup.8Arg.sup.26Lys.sup.34,39-bis-(Aspa-AHex)-GLP-1(7-39);
Ser.sup.8Arg.sup.34Lys.sup.26,39-bis-(Aspa-AHex)-GLP-1(7-39);
Ser.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Aspa-AHex)-GLP-1(7-39);
[1201] Thr.sup.8Lys.sup.26,34-bis-(Aspa-AHex)-GLP-1(7-36);
Thr.sup.8Lys.sup.26,34-bis-(Aspa-AHex)-GLP-1(7-37);
Thr.sup.8Lys.sup.26,34-bis-(Aspa-AHex)-GLP-1(7-38);
Thr.sup.8Lys.sup.26,34-bis-(Aspa-AHex)-GLP-1(7-39)
Thr.sup.8Arg.sup.26Lys.sup.34,36-bis-(Aspa-AHex)-GLP-1(7-36);
Thr.sup.8Arg.sup.34Lys.sup.26,36-bis-(Aspa-AHex)-GLP-1(7-36);
Thr.sup.8Arg.sup.26Lys.sup.34,36-bis-(Aspa-AHex)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26,36-bis-(Aspa-AHex)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34,37-bis-(Aspa-AHex)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26,37-bis-(Aspa-AHex)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34,38-bis-(Aspa-AHex)-GLP-1(7-38);
Thr.sup.8Arg.sup.34Lys.sup.26,38-bis-(Aspa-AHex)-GLP-1(7-38);
Thr.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Aspa-AHex)-GLP-1(7-38);
Thr.sup.8Arg.sup.26Lys.sup.34,39-bis-(Aspa-AHex)-GLP-1(7-39);
Thr.sup.8Arg.sup.34Lys.sup.26,39-bis-(Aspa-AHex)-GLP-1(7-39);
Thr.sup.8Arg.sup.26,34Lys.sup.26,39-bis-(Aspa-AHex)-GLP-1(7-39);
[1202] Lys.sup.26,34-bis-(Aspa-AOct)-GLP-1(7-36);
Lys.sup.26,34-bis-(Aspa-AOct)-GLP-1(7-37);
Lys.sup.2-bis-(Aspa-AOct)-GLP-1(7-38);
Lys.sup.26,34-bis-(Aspa-AOct)-GLP-1(7-39)
Arg.sup.26Lys.sup.34,36-bis-(Aspa-AOct)-GLP-1(7-36);
Arg.sup.34Lys.sup.26,36-bis-(Aspa-AOct)-GLP-1(7-36);
Arg.sup.26Lys.sup.34,36-bis-(Aspa-AOct)-GLP-1(7-37);
Arg.sup.34Lys.sup.26,36-bis-(Aspa-AOct)-GLP-1(7-37);
Arg.sup.26Lys.sup.34,37-bis-(Aspa-AOct)-GLP-1(7-37);
Arg.sup.34Lys.sup.26,37-bis-(Aspa-AOct)-GLP-1(7-37);
Arg.sup.26Lys.sup.34,39-bis-(Aspa-AOct)-GLP-1(7-39);
Arg.sup.34Lys.sup.26,39-bis-(Aspa-AOct)-GLP-1(7-39);
Arg.sup.26,34Lys.sup.36,39-bis-(Aspa-AOct)-GLP-1(7-39);
[1203] Arg.sup.26Lys.sup.18,34-bis-(Aspa-AOct)-GLP-1(7-36);
Arg.sup.34Lys.sup.18,26-bis-(Aspa-AOct)-GLP-1(7-36);
Arg.sup.26Lys.sup.18,34-bis-(Aspa-AOct)-GLP-1(7-37);
Arg.sup.34Lys.sup.18,26-bis-(Aspa-AOct)-GLP-1(7-37);
Arg.sup.26Lys.sup.18,34-bis-(Aspa-AOct)-GLP-1(7-38);
Arg.sup.34Lys.sup.18,26-bis-(Aspa-AOct)-GLP-1(7-38);
Arg.sup.26Lys.sup.18,34-bis-(Aspa-AOct)-GLP-1(7-39);
Arg.sup.34Lys.sup.18,26-bis-(Aspa-AOct)-GLP-1(7-39);
Arg.sup.26Lys.sup.23,34-bis-(Aspa-AOct)-GLP-1(7-36);
Arg.sup.34Lys.sup.23,26-bis-(Aspa-AOct)-GLP-1(7-36);
Arg.sup.26Lys.sup.23,34-bis-(Aspa-AOct)-GLP-1(7-37);
Arg.sup.34Lys.sup.23,26-bis-(Aspa-AOct)-GLP-1(7-37);
Arg.sup.26Lys.sup.23,34-bis-(Aspa-AOct)-GLP-1(7-38);
Arg.sup.34Lys.sup.23,26-bis-(Aspa-AOct)-GLP-1(7-38);
Arg.sup.26Lys.sup.23,34-bis-(Aspa-AOct)-GLP-1(7-39);
Arg.sup.34Lys.sup.23,26-bis-(Aspa-AOct)-GLP-1(7-39);
Arg.sup.26Lys.sup.27,34-bis-(Aspa-AOct)-GLP-1(7-36);
Arg.sup.34Lys.sup.27,26-bis-(Aspa-AOct)-GLP-1(7-36);
Arg.sup.26Lys.sup.27,34-bis-(Aspa-AOct)-GLP-1(7-37);
Arg.sup.34Lys.sup.27,26-bis-(Aspa-AOct)-GLP-1(7-37);
Arg.sup.26Lys.sup.27,34-bis-(Aspa-AOct)-GLP-1(7-38);
Arg.sup.34Lys.sup.27,26-bis-(Aspa-AOct)-GLP-1(7-38);
Arg.sup.26Lys.sup.27,34-bis-(Aspa-AOct)-GLP-1(7-39);
Arg.sup.34Lys.sup.27,26-bis-(Aspa-AOct)-GLP-1(7-39);
Gly.sup.8Lys.sup.26,34-bis-(Aspa-AOct)-GLP-1(7-36);
Gly.sup.8Lys.sup.26,34-bis-(Aspa-AOct)-GLP-1(7-37);
Gly.sup.8Lys.sup.26,34-bis-(Aspa-AOct)-GLP-1(7-38);
Gly.sup.8Lys.sup.26,34-bis-(Aspa-AOct)-GLP-1(7-39)
Gly.sup.8Arg.sup.26Lys.sup.34,36-bis-(Aspa-AOct)-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys26,36-bis-(Aspa-AOct)-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.34,36-bis-(Aspa-AOct)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26,36-bis-(Aspa-AOct)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34,37-bis-(Aspa-AOct)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26,37-bis-(Aspa-AOct)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34,38-bis-(Aspa-AOct)-GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.26,38-bis-(Aspa-AOct)-GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Aspa-AOct)-GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.34,39-bis-(Aspa-AOct)-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.26,39-bis-(Aspa-AOct)-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Aspa-A
Oct)-GLP-1(7-39);
[1204] Val.sup.8Lys.sup.26,34-bis-(Aspa-AOct)-GLP-1(7-36);
Val.sup.8Lys.sup.26,34-bis-(Aspa-AOct)-GLP-1(7-37);
Val.sup.8Lys.sup.26,34-bis-(Aspa-AOct)-GLP-1(7-38);
Val.sup.8Lys.sup.26,34-bis-(Aspa-AOct)-GLP-1(7-39)
Val.sup.8Arg.sup.26Lys.sup.34,36-bis-(Aspa-AOct)-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.26,36-bis-(Aspa-AOct)-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.34,36-bis-(Aspa-AOct)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26,36-bis-(Aspa-AOct)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34,37-bis-(Aspa-AOct)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26,37-bis-(Aspa-AOct)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34,38-bis-(Aspa-AOct)-GLP-1(7-38);
Val.sub.8Arg.sup.34Lys.sup.26,38-bis-(Aspa-AOct)-GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Aspa-AOct)-GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.34,39-bis-(Aspa-AOct)-GLP-1(7-39;
Val.sup.8Arg.sup.34Lys.sup.26,39-bis-(Aspa-AOct)-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Aspa-AOct)-GLP-1(7-39);
[1205] Ser.sup.8Lys.sup.26,34-bis-(Aspa-AOct)-GLP-1(7-36);
Ser.sup.8Lys.sup.26,36-bis-(Aspa-AOct)-GLP-1(7-37);
Ser.sup.8Lys.sup.26,34-bis-(Aspa-AOct)-GLP-1(7-38);
Ser.sup.8Lys.sup.26,34-bis-(Aspa-AOct)-GLP-1(7-39);
Ser.sup.8Arg.sup.26Lys.sup.34,36-bis-(Aspa-AOct)-GLP-1(7-36);
Ser.sup.8Arg.sup.34Lys.sup.26,36-bis-(Aspa-AOct)-GLP-1(7-36);
Ser.sup.8Arg.sup.26Lys.sup.36,36-bis-(Aspa-AOct)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26,34-bis-(Aspa-AOct)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34,37-bis-(Aspa-AOct)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26,37-bis-(Aspa-AOct)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34,38-bis-(Aspa-AOct)-GLP-1(7-38);
Ser.sup.8Arg.sup.34Lys.sup.26,38-bis-(Aspa-AOct)-GLP-1(7-38);
Ser.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Aspa-AOct)-GLP-1(7-38);
Ser.sup.8Arg.sup.26Lys.sup.34,39-bis-(Aspa-AOct)-GLP-1(7-39);
Ser.sup.8Arg.sup.34Lys.sup.26,39-bis-(Aspa-AOct)-GLP-1(7-39);
Ser.sup.8Arg.sup.26,34Lys.sup.1,3-bis-(Aspa-AOct)-GLP-1(7-39);
[1206] Thr.sup.8Lys.sup.26,34-bis-(Aspa-AOct)-GLP-1(7-36);
Thr.sup.8Lys.sup.26,34-bis-(Aspa-AOct)-GLP-1(7-37);
Thr.sup.8Lys.sup.26,34-bis-(Aspa-AOct)-GLP-1(7-38);
Thr.sup.8Lys.sup.26,34-bis-(Aspa-AOct)-GLP-1(7-39)
Thr.sup.8Arg.sup.26Lys.sup.34,36-bis-(Aspa-AOct)-GLP-1(7-36);
Thr.sup.8Arg.sup.34Lys.sup.26,36-bis-(Aspa-AOct)-GLP-1(7-36);
Thr.sup.8Arg.sup.26Lys.sup.34,36-bis-(Aspa-AOct)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26,36-bis-(Aspa-AOct)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34,37-bis-(Aspa-AOct)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26,37-bis-(Aspa-AOct)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34,38-bis-(Aspa-AOct)-GLP-1(7-38);
Thr.sup.8Arg.sup.34Lys.sup.26,37-bis-(Aspa-AOct)-GLP-1(7-37);
Thr.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Aspa-AOct)-GLP-1(7-38);
Thr.sup.8Arg.sup.26Lys.sup.34,39-bis-(Aspa-AOct)-GLP-1(7-39);
Thr.sup.8Arg.sup.34Lys.sup.26,39-bis-(Aspa-AOct)-GLP-1(7-39);
Thr.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Aspa-AOct)-GLP-1(7-39);
[1207] Lys.sup.26,34-bis-(Aspa-ALit)-GLP-1(7-36);
Lys.sup.26,34-bis-(Aspa-ALit)-GLP-1(7-37);
Lys.sup.26,34-bis-(Aspa-ALit)-GLP-1(7-38);
Lys.sup.26,34-bis-(Aspa-ALit)-GLP-1(7-39)
Arg.sup.26Lys.sup.34,36-bis-(Aspa-ALit)-GLP-1(7-36);
Arg.sup.34Lys.sup.26,36-bis-(Aspa-ALit)-GLP-1(7-36);
Arg.sup.26Lys.sup.34,36-bis-(Aspa-ALit)-GLP-1(7-37);
Arg.sup.34Lys.sup.26,36-bis-(Aspa-ALit)-GLP-1(7-37);
Arg.sup.26Lys.sup.34,37-bis-(Aspa-ALit)-GLP-1(7-37);
Arg.sup.34Lys.sup.26,37-bis-(Aspa-ALit)-GLP-1(7-37);
Arg.sup.26Lys.sup.34,39-bis-(Aspa-ALit)-GLP-1(7-39);
Arg.sup.34Lys.sup.26,39-bis-(Aspa-ALit)-GLP-1(7-39);
Arg.sup.26,34Lys.sup.36,39-bis-(Aspa-ALit)-GLP-1(7-39);
[1208] Arg.sup.26Lys.sup.18,34-bis-(Aspa-ALit)-GLP-1(7-36);
Arg.sup.34Lys.sup.18,26-bis-(Aspa-ALit)-GLP-1(7-36);
Arg.sup.26Lys.sup.18,34-bis-(Aspa-ALit)-GLP-1(7-37);
Arg.sup.34Lys.sup.18,26-bis-(Aspa-ALit)-GLP-1(7-37);
Arg.sup.26Lys.sup.18,34-bis-(Aspa-ALit)-GLP-1(7-38);
Arg.sup.34Lys.sup.18,26-bis-(Aspa-ALit)-GLP-1(7-38);
Arg.sup.26Lys.sup.18,34-bis-(Aspa-ALit)-GLP-1(7-39);
Arg.sup.34Lys.sup.18,26-bis-(Aspa-ALit)-GLP-1(7-39);
Arg.sup.26Lys.sup.23,34-bis-(Aspa-ALit)-GLP-1(7-36);
Arg.sup.34Lys.sup.23,26-bis-(Aspa-ALit)-GLP-1(7-36);
Arg.sup.26,34Lys.sup.23,34-bis-(Aspa-ALit)-GLP-1(7-37);
Arg.sup.34Lys.sup.23,26-bis-(Aspa-ALit)-GLP-1(7-37);
Arg.sup.26Lys.sup.23,34-bis-(Aspa-ALit)-GLP-1(7-38);
Arg.sup.34Lys.sup.23,26-bis-(Aspa-ALit)-GLP-1(7-38);
Arg.sup.26Lys.sup.23,34-bis-(Aspa-ALit)-GLP-1(7-39);
Arg.sup.34Lys.sup.23,26-bis-(Aspa-ALit)-GLP-1(7-39);
Arg.sup.26Lys.sup.27,34-bis-(Aspa-ALit)-GLP-1(7-36);
Arg.sup.34Lys.sup.27,26-bis-(Aspa-ALit)-GLP-1(7-36);
Arg.sup.26Lys.sup.27,34-bis-(Aspa-ALit)-GLP-1(7-37);
Arg.sup.34Lys.sup.27,26-bis-(Aspa-ALit)-GLP-1(7-37);
Arg.sup.26Lys.sup.27,34-bis-(Aspa-ALit)-GLP-1(7-38);
Arg.sup.34Lys.sup.27,26-bis-(Aspa-ALit)-GLP-1(7-38);
Arg.sup.26Lys27,34-bis-(Aspa-ALit)-GLP-1(7-39);
Arg.sup.34Lys.sup.27,26-bis-(Aspa-ALit)-GLP-1(7-39);
Gly.sup.8Lys.sup.26,34-bis-(Aspa-ALit)-GLP-1(7-36);
Gly.sup.8Lys.sup.26,34-bis-(Aspa-ALit)-GLP-1(7-37);
Gly.sup.8Lys.sup.26,34-bis-(Aspa-ALit)-GLP-1(7-38);
Gly.sup.8Lys.sup.26,34-bis-(Aspa-ALit)-GLP-1(7-39);
Gly.sup.8Arg.sup.26Lys.sup.34,36-bis-(Aspa-ALit)-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.26,36-bis-(Aspa-ALit)-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.34,36-bis-(Aspa-ALit)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26,36-bis-(Aspa-ALit)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34,37-bis-(Aspa-ALit)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26,37-bis-(Aspa-ALit)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34,38-bis-(Aspa-ALit)-GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.26,38-bis-(Aspa-ALit)-GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Aspa-ALit)-GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.34,39-bis-(Aspa-ALit)-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.26,39-bis-(Aspa-ALit)-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Aspa-ALit)-GLP-1(7-39);
[1209] Val.sup.8Lys.sup.26,34-bis-(Aspa-ALit)-GLP-1(7-36);
Val.sup.8Lys.sup.26,34-bis-(Aspa-ALit)-GLP-1(7-37);
Val.sup.8Lys.sup.26,34-bis-(Aspa-ALit)-GLP-1(7-38);
Val.sup.8Lys.sup.26,34-bis-(Aspa-ALit)-GLP-1(7-39)
Val.sup.8Arg.sup.26Lys.sup.34,36-bis-(Aspa-ALit)-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.26,36-bis-(Aspa-ALit)-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.34,36-bis-(Aspa-ALit)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26,36-bis-(Aspa-ALit)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34,37-bis-(Aspa-ALit)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26,37-bis-(Aspa-ALit)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34,38-bis-(Aspa-ALit)-GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.26,38-bis-(Aspa-ALit)-GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Aspa-ALit)-GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.34,39-bis-(Aspa-ALit)-GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.26,39-bis-(Aspa-ALit)-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Aspa-ALit)-GLP-1(7-39);
[1210] Ser.sup.8Lys.sup.26,34-bis-(Aspa-ALit)-GLP-1(7-36);
Ser.sup.8Lys.sup.26,34-bis-(Aspa-ALit)-GLP-1(7-37);
Ser.sup.8Lys.sup.26,34-bis-(Aspa-ALit)-GLP-1(7-38);
Ser.sup.8Lys26,34-bis-(Aspa-ALit)-GLP-1(7-39)
Ser.sup.8Arg.sup.26Lys.sup.34,36-bis-(Aspa-ALit)-GLP-1(7-36);
Ser.sup.8Arg.sup.34Lys.sup.26,36-bis-(Aspa-ALit)-GLP-1(7-36);
Ser.sup.8Arg.sup.26Lys.sup.34,36-bis-(Aspa-ALit)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26,36-bis-(Aspa-ALit)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34,37-bis-(Aspa-ALit)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26,37-bis-(Aspa-ALit)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34,38-bis-(Aspa-ALit)-GLP-1(7-38);
Ser.sup.8Arg.sup.34Lys.sup.26,38-bis-(Aspa-ALit)-GLP-1(7-38);
Ser.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Aspa-ALit)-GLP-1(7-38);
Ser.sup.8Arg.sup.26Lys.sup.34,39-bis-(Aspa-ALit)-GLP-1(7-39);
Ser.sup.8Arg.sup.34Lys.sup.26,39-bis-(Aspa-ALit)-GLP-1(7-39);
Ser.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Aspa-ALit)-GLP-1(7-39);
Thr.sup.8Lys.sup.26,34-bis-(Aspa-ALit)-GLP-1(7-36);
Thr.sup.8Lys.sup.26,34-bis-(Aspa-ALit)-GLP-1(7-37);
Thr.sup.8Lys.sup.26,34-bis-(Aspa-ALit)-GLP-1(7-38);
Thr.sup.8Lys.sup.26,34-bis-(Aspa-ALit)-GLP-1(7-39);
Thr.sup.8Arg.sup.26Lys.sup.34,36-bis-(Aspa-ALit)-GLP-1(7-36);
Thr.sup.8Arg.sup.34Lys.sup.26,36-bis-(Aspa-ALit)-GLP-1(7-36);
Thr.sup.8Arg.sup.26Lys.sup.34,36-bis-(Aspa-ALit)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26,36-bis-(Aspa-ALit)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34,37-bis-(Aspa-ALit)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26,37-bis-(Aspa-ALit)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34,38-bis-(Aspa-ALit)-GLP-1(7-38);
Thr.sup.8Arg.sup.34Lys.sup.26,38-bis-(Aspa-ALit)-GLP-1(7-38);
Thr.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Aspa-ALit)-GLP-1(7-38);
Thr.sup.8Arg.sup.26Lys.sup.34,39-bis-(Aspa-ALit)-GLP-1(7-39);
Thr.sup.8Arg.sup.34Lys.sup.26,39-bis-(Aspa-ALit)-GLP-1(7-39);
Thr.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Aspa-ALit)-GLP-1(7-39);
[1211] Lys.sup.26,34-bis-(Glyc-ADod)-GLP-1(7-36);
Lys.sup.26,34-bis-(Glyc-ADod)-GLP-1(7-37);
Lys.sup.26,34-bis-(Glyc-ADod)-GLP-1(7-38);
Lys.sup.26,34-bis-(Glyc-ADod)-GLP-1(7-39)
Arg.sup.26Lys.sup.34,36-bis-(Glyc-ADod)-GLP-1(7-36);
Arg.sup.34Lys.sup.26,36-bis-(Glyc-ADod)-GLP-1(7-36);
Arg.sup.26Lys.sup.34,36-bis-(Glyc-ADod)-GLP-1(7-37);
Arg.sup.34Lys.sup.26,36-bis-(Glyc-ADod)-GLP-1(7-37);
Arg.sup.26Lys.sup.34,37-bis-(Gly-ADod)-GLP-1(7-37);
Arg.sup.34Lys.sup.26,37-bis-(Glyc-ADod)-GLP-1(7-37);
Arg.sup.26Lys.sup.34,39-bis-(Glyc-ADod)-GLP-1(7-39);
Arg.sup.34Lys.sup.26,39-bis-(Glyc-ADod)-GLP-1(7-39);
Arg.sup.26,34Lys.sup.36,39-bis-(Glyc-ADod)-GLP-1(7-39);
[1212] Arg.sup.26Lys.sup.18,34-bis-(Glyc-ADod)-GLP-1(7-36);
Arg.sup.34Lys.sup.18,26-bis-(Glyc-ADod)-GLP-1(7-36);
Arg.sup.26Lys.sup.18,34-bis-(Glyc-ADod)-GLP-1(7-37);
Arg.sup.34Lys.sup.18,26-bis-(Glyc-ADod)-GLP-1(7-37);
Arg.sup.26Lys.sup.18,26-bis-(Glyc-ADod)-GLP-1(7-38);
Arg.sup.34Lys.sup.18,26-bis-(Glyc-ADod)-GLP-1(7-38);
Arg.sup.26Lys.sup.18,34-bis-(Glyc-ADod)-GLP-1(7-39);
Arg.sup.34Lys.sup.18,26-bis-(Glyc-ADod)-GLP-1(7-39);
Arg.sup.26Lys.sup.18,34-bis-(Glyc-ADod)-GLP-1(7-36);
Arg.sup.34Lys.sup.23,26-bis-(Glyc-ADod)-GLP-1(7-36);
Arg.sup.26Lys.sup.23,34-bis-(Glyc-ADod)-GLP-1(7-37);
Arg.sup.34Lys.sup.23,26-bis-(Glyc-ADod)-GLP-1(7-37);
Arg.sup.26Lys.sup.23,34-bis-(Glyc-ADod)-GLP-1(7-38);
Arg.sup.34Lys.sup.23,26-bis-(Glyc-ADod)-GLP-1(7-38);
Arg.sup.26Lys.sup.23,34-bis-(Glyc-ADod)-GLP-1(7-39);
Arg.sup.34Lys.sup.23,26-bis-(Glyc-ADod)-GLP-1(7-39);
Arg.sup.26Lys.sup.27,34-bis-(Glyc-ADod)-GLP-1(7-36);
Arg.sup.34Lys.sup.23,26-bis-(Glyc-ADod)-GLP-1(7-36);
Arg.sup.26Lys.sup.27,34-bis-(Glyc-ADod)-GLP-1(7-37);
Arg.sup.34Lys.sup.27,26-bis-(Glyc-ADod)-GLP-1(7-37);
Arg.sup.26Lys.sup.27,34-bis-(Glyc-ADod)-GLP-1(7-38);
Arg.sup.34Lys.sup.27,26-bis-(Glyc-ADod)-GLP-1(7-38);
Arg.sup.26Lys.sup.27,34-bis-(Glyc-ADod)-GLP-1(7-39);
Arg.sup.34Lys.sup.27,26-bis-(Glyc-ADod)-GLP-1(7-39);
Gly.sup.8Lys.sup.26,34-bis-(Glyc-ADod)-GLP-1(7-36);
Gly.sup.8Lys.sup.26,34-bis-(Glyc-ADod)-GLP-1(7-37);
Gly.sup.8Lys.sup.26,34-bis-(Glyc-ADod)-GLP-1(7-38);
Gly.sup.8Lys.sup.26,34-bis-(Glyc-ADod)-GLP-1(7-39)
Gly.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glyc-ADod)-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glyc-ADod)-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glyc-ADod)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glyc-ADod)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34,37-bis-(Glyc-ADod)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26,37-bis-(Glyc-ADod)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34,38-bis-(Glyc-ADod)-GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.26,38-bis-(Glyc-ADod)-GLP-1(Glyc-ADod)-GLP-1(7-
-38);
Gly.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Glyc-ADod)-GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.34,39-bis-(Glyc-ADod)-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.26,39-bis-(Glyc-ADod)-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Glyc-ADod)-GLP-1(7-39);
[1213] Val.sup.8Lys.sup.26,34-bis-(Glyc-ADod)-GLP-1(7-36);
Val.sup.8Lys.sup.26,34-bis-(Glyc-ADod)-GLP-1(7-37);
Val.sup.8Lys.sup.26,34-bis-(Glyc-ADod)-GLP-1(7-38);
Val.sup.8Lys.sup.26,34-bis-(Glyc-ADod)-GLP-1(7-39)
Val.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glyc-ADod)-GLP-1(7-36);
Val.sup.1Arg.sup.34Lys.sup.26,36-bis-(Glyc-ADod)-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.4,36-bis-(Glyc-ADod)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glyc-ADod)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34,37-bis-(Glyc-ADod)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26,37-bis-(Glyc-ADod)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34,38-bis-(Glyc-ADod)-GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.26,38-bis-(Glyc-ADod)-GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Glyc-ADod)-GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.34,39-bis-(Glyc-ADod)-GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.26,39-bis-(Glyc-ADod)-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Glyc-ADod)-GLP-1(7-39);
[1214] Ser.sup.8Lys.sup.26,34-bis-(Glyc-ADod)-GLP-1(7-36);
Ser.sup.8Lys.sup.26,34-bis-(Glyc-ADod)-GLP-1(7-37);
Ser.sup.8Lys.sup.26,34-bis-(Glyc-ADod)-GLP-1(7-38);
Ser.sup.8Lys.sup.26,34-bis-(Glyc-ADod)-GLP-1(7-39)
Ser.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glyc-ADod)-GLP-1(7-36);
Ser.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glyc-ADod)-GLP-1(7-36);
Ser.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glyc-ADod)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glyc-ADod)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34,37-bis-(Glyc-ADod)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26,37-bis-(Glyc-ADod)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34,38-bis-(Glyc-ADod)-GLP-1(7-38);
Ser.sup.8Arg.sup.34Lys.sup.26,38-bis-(Glyc-ADod)-GLP-1(7-38);
Ser.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Glyc-ADod)-GLP-1(7-38);
Ser.sup.8Arg.sup.26Lys.sup.34,39-bis-(Glyc-ADod)-GLP-1(7-39);
Ser.sup.8Arg.sup.34Lys.sup.26,39-bis-(Glyc-ADod)-GLP-1(7-39);
Ser.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Glyc-ADod)-GLP-1(7-39);
[1215] Thr.sup.8Lys.sup.26,34-bis-(Glyc-ADod)-GLP-1(7-36);
Thr.sup.8Lys.sup.26,34-bis-(Glyc-ADod)-GLP-1(7-37);
Thr.sup.8Lys.sup.26,34-bis-(Glyc-ADod)-GLP-1(7-38);
Thr.sup.8Lys.sup.26,34-bis-(Glyc-ADod)-GLP-1(7-39)
Thr.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glyc-ADod)-GLP-1(7-36);
Thr.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glyc-ADod)-GLP-1(7-36);
Thr.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glyc-ADod)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glyc-ADod)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34,37-bis-(Glyc-ADod)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26,37-bis-(Glyc-ADod)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34,38-bis-(Glyc-ADod)-GLP-1(7-38);
Thr.sup.8Arg.sup.34Lys.sup.26,38-bis-(Glyc-ADod)-GLP-1(7-38);
Thr.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Glyc-ADod)-GLP-1(7-38);
Thr.sup.8Arg.sup.26Lys.sup.34,39-bis-(Glyc-ADod)-GLP-1(7-39);
Thr.sup.8Arg.sup.34Lys.sup.26,39-bis-(Glyc-ADod)-GLP-1(7-39);
Thr.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Glyc-ADod)-GLP-1(7-39);
[1216] Lys.sup.26,34-bis-(Glyc-ATet)-GLP-1(7-36);
Lys.sup.26,34-bis-(Glyc-ATet)-GLP-1(7-37);
Lys.sup.26,34-bis-(Glyc-ATet)-GLP-1(7-38);
Lys.sup.26,34-bis-(Glyc-ATet)-GLP-1(7-39)
Arg.sup.26Lys.sup.34,36-bis-(Glyc-ATet)-GLP-1(7-36);
Arg.sup.34Lys.sup.26,36-bis-(Glyc-ATet)-GLP-1(7-36);
Arg.sup.26Lys.sup.34,36-bis-(Glyc-ATet)-GLP-1(7-37);
Arg.sup.34Lys.sup.26,36-bis-(Glyc-ATet)-GLP-1(7-37);
Arg.sup.26Lys.sup.34,37-bis-(Glyc-ATet)-GLP-1(7-37);
Arg.sup.34Lys.sup.26,37-bis-(Glyc-ATet)-GLP-1(7-37);
Arg.sup.26Lys.sup.34,39-bis-(Glyc-ATet)-GLP-1(7-39);
Arg.sup.34Lys.sup.26,39-bis-(Glyc-ATet)-GLP-1(7-39);
Arg.sup.26,34Lys.sup.36,39-bis-(Glyc-ATet)-GLP-1(7-39);
Arg.sup.26Lys.sup.18,34-bis-(Glyc-ATet)-GLP-1(7-36);
Arg.sup.34Lys.sup.18,26-bis-(Glyc-ATet)-GLP-1(7-36);
Arg.sup.26Lys.sup.18,34-bis-(Glyc-ATet)-GLP-1(7-37);
Arg.sup.34Lys.sup.18,26-bis-(Glyc-ATet)-GLP-1(7-37);
Arg.sup.26Lys.sup.18,34-bis-(Glyc-ATet)-GLP-1(7-38);
Arg.sup.34Lys.sup.18,26-bis-(Glyc-ATet)-GLP-1(7-38);
Arg.sup.26Lys.sup.18,34-bis-(Glyc-ATet)-GLP-1(7-39);
Arg.sup.34Lys.sup.18,26-bis-(Glyc-ATet)-GLP-1(7-39);
Arg.sup.26Lys.sup.23,34-bis-(Glyc-ATet)-GLP-1(7-36);
Arg.sup.34Lys.sup.23,26-bis-(Glyc-ATet)-GLP-1(7-36);
Arg.sup.26Lys.sup.23,34-bis-(Glyc-ATet)-GLP-1(7-37);
Arg.sup.34Lys.sup.23,26-bis-Glyc-ATet)-GLP-1(7-37);
Arg.sup.26Lys.sup.23,34-bis-(Glyc-ATet)-GLP-1(7-38);
Arg.sup.34Lys.sup.23,26-bis-(Glyc-ATet)-GLP-1(7-38);
Arg.sup.26Lys.sup.23,34-bis-(Glyc-ATet)-GLP-1(7-39);
Arg.sup.34Lys.sup.23,26-bis-(Glyc-ATet)-GLP-1(7-39);
Arg.sup.26Lys.sup.27,34-bis-(Glyc-ATet)-GLP-1(7-36);
Arg.sup.34Lys.sup.27,26-bis-(Glyc-ATet)-GLP-1(7-36);
Arg.sup.26Lys.sup.27,34-bis-(Glyc-ATet)-GLP-1(7-37);
Arg.sup.34Lys.sup.27,26-bis-(Glyc-ATet)-GLP-1(7-37);
Arg.sup.26Lys.sup.27,34-bis-(Glyc-ATet)-GLP-1(7-38);
Arg.sup.34Lys.sup.27,26-bis-(Glyc-ATet)-GLP-1(7-38);
Arg.sup.26Lys.sup.27,34-bis-(Glyc-ATet)-GLP-1(7-39);
Arg.sup.34Lys.sup.27,26-bis-(Glyc-ATet)-GLP-1(7-39);
Gly.sup.8Lys.sup.26,34-bis-(Glyc-ATet)-GLP-1(7-36);
Gly.sup.8Lys.sup.26,34-bis-(Glyc-ATet)-GLP-1(7-37);
Gly.sup.8Lys.sup.26,34-bis-(Glyc-ATet)-GLP-1(7-38);
Gly.sup.8Lys.sup.26,34-bis-(Glyc-ATet)-GLP-1(7-39);
Gly.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glyc-ATet)-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glyc-ATet)-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glyc-ATet)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glyc-ATet)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34,37-bis-(Glyc-ATet)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26,37-bis-(Glyc-ATet)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34,38-bis-(Glyc-ATet)-GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.26,38-bis-(Glyc-ATet)-GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Glyc-ATet)-GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.34,39-bis-(Glyc-ATet)-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.26,39-bis-(Glyc-ATet)-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Glyc-ATet)-GLP-1(7-39);
[1217] Val.sup.8Lys.sup.26,34-bis-(Glyc-ATet)-GLP-1(7-36);
Val.sup.8Lys.sup.26,34-bis-(Glyc-ATet)-GLP-1(7-37);
Val.sup.8Lys.sup.26,34-bis-(Glyc-ATet)-GLP-1(7-38);
Val.sup.8Lys.sup.26,34-bis-(Glyc-ATet)-GLP-1(7-39)
Val.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glyc-ATet)-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glyc-ATet)-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glyc-ATet)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glyc-ATet)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34,37-bis-(Glyc-ATet)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26,37-bis-(Glyc-ATet)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34,38-bis-(Glyc-ATet)-GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.26,38-bis-(Glyc-ATet)-GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Glyc-ATet)-GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.34,39-bis-(Glyc-ATet)-GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.26,39-bis-(Glyc-ATet)-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Glyc-ATet)-GLP-1(7-39);
[1218] Ser.sup.8Lys.sup.26,34-bis-(Glyc-ATet)-GLP-1(7-36);
Ser.sup.8Val.sup.26,34-bis-(Glyc-ATet)-GLP-1(7-37);
Ser.sup.8Lys.sup.26,34-bis-(Glyc-ATet)-GLP-1(7-38);
Ser.sup.8Lys.sup.26,34-bis-(Glyc-ATet)-GLP-1(7-39)
Ser.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glyc-ATet)-GLP-1(7-36);
Ser.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glyc-ATet)-GLP-1(7-36);
Ser.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glyc-ATet)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glyc-ATet)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34,37-bis-(Glyc-ATet)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26,37-bis-(Glyc-ATet)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34,38-bis-(Glyc-ATet)-GLP-1(7-38);
Ser.sup.8Arg.sup.34Lys.sup.26,38-bis-(Glyc-ATet)-GLP-1(7-38);
Ser.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Glyc-ATet)-GLP-1(7-38);
Ser.sup.8Arg.sup.26Lys.sup.34,39-bis-(Glyc-ATet)-GLP-1(7-39);
Ser.sup.8Arg.sup.34Lys.sup.26,39-bis-(Glyc-ATet)-GLP-1(7-39);
Ser.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Glyc-ATet)-GLP-1(7-39);
[1219] Thr.sup.8Lys.sup.26,34-bis-(Glyc-ATet)-GLP-1(7-36);
Thr.sup.8Lys.sup.26,34-bis-(Glyc-ATet)-GLP-1(7-37);
Thr.sup.8Lys.sup.26,34-bis-(Glyc-ATet)-GLP-1(7-38);
Thr.sup.8Lys.sup.26,34-bis-(Glyc-ATet)-GLP-1(7-39)
Thr.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glyc-ATet)-GLP-1(7-36);
Thr.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glyc-ATet)-GLP-1(7-36);
Thr.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glyc-ATet)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glyc-ATet)-GLP-1(7-37);
Thr.sup.8(Arg.sup.26Lys.sup.34,37-bis-(Glyc-ATet)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26,37-bis-(Glyc-ATet)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34,38-bis-(Glyc-ATet)-GLP-1(7-38);
Thr.sup.8Arg.sup.34Lys.sup.26,38-bis-(Glyc-ATet)-GLP-1(7-38);
Thr.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Glyc-ATet)-GLP-1(7-38);
Thr.sup.8Arg.sup.26Lys.sup.34,39-bis-(Glyc-ATet)-GLP-1(7-39);
Thr.sup.8Arg.sup.34Lys.sup.26,39-bis-(Glyc-ATet)-GLP-1(7-39);
Thr.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Glyc-ATet)-GLP-1(7-39);
[1220] Lys.sup.26,34-bis-(Glyc-AHex)-GLP-1(7-36);
Lys.sup.26,34-bis-(Glyc-AHex)-GLP-1(7-37);
Lys.sup.26,34-bis-(Glyc-AHex)-GLP-1(7-38);
Lys.sup.26,34-bis-(Glyc-AHex)-GLP-1(7-39)
Arg.sup.26Lys.sup.34,36-bis-(Glyc-AHex)-GLP-1(7-36);
Arg.sup.34Lys.sup.26,36-bis-(Glyc-AHex)-GLP-1(7-36);
Arg.sup.26Lys.sup.34,36-bis-(Glyc-AHex)-GLP-1(7-37);
Arg.sup.34Lys.sup.26,36-bis-(Glyc-AHex)-GLP-1(7-37);
Arg.sup.26Lys.sup.34,37-bis-(Glyc-AHex)-GLP-1(7-37);
Arg.sup.34Lys.sup.26,37-bis-(Glyc-AHex)-GLP-1(7-37);
Arg.sup.26Lys.sup.34,39-bis-(Glyc-AHex)-GLP-1(7-39);
Arg.sup.34Lys.sup.26,39-bis-(Glyc-AHex)-GLP-1(7-39);
Arg.sup.26,34Lys.sup.36,39-bis-(Glyc-AHex)-GLP-1(7-39);
[1221] Arg.sup.26Lys.sup.18,34-bis-(Glyc-AHex)-GLP-1(7-36);
Arg.sup.34Lys.sup.18,26-bis-(Glyc-AHex)-GLP-1(7-36);
Arg.sup.26Lys.sup.18,34-bis-(Glyc-AHex)-GLP-1(7-37);
Arg.sup.34Lys.sup.18,26-bis-(Glyc-AHex)-GLP-1(7-37);
Arg.sup.26Lys.sup.18,34-bis-(Glyc-AHex)-GLP-1(7-38);
Arg.sup.34Lys.sup.18,26-bis-(Glyc-AHex)-GLP-1(7-38);
Arg.sup.26Lys.sup.18,34-bis-(Glyc-AHex)-GLP-1(7-39);
Arg.sup.34Lys.sup.18,26-bis-(Glyc-AHex)-GLP-1(7-39);
Arg.sup.26Lys.sup.23,34-bis-(Glyc-AHex)-GLP-1(7-36);
Arg.sup.34Lys.sup.23,26-bis-(Glyc-AHex)-GLP-1(7-36);
Arg.sup.26Lys.sup.23,34-bis-(Glyc-Alex)-GLP-1(7-37);
Arg.sup.34Lys.sup.23,26-bis-(Glyc-AHex)-GLP-1(7-37);
Arg.sup.26Lys.sup.23,34-bis-(Glyc-AHex)-GLP-1(7-38);
Arg.sup.34Lys.sup.23,26-bis-(Glyc-AHex)-GLP-1(7-38);
Arg.sup.26Lys.sup.23,34-bis-(Glyc-AHex)-GLP-1(7-39);
Arg.sup.34Lys.sup.23,26-bis-(Glyc-AHex)-GLP-1(7-39);
Arg.sup.26Lys.sup.27,34-bis-(Glyc-AHex)-GLP-1(7-36);
Arg.sup.34Lys.sup.27,26-bis-(Glyc-AHex)-GLP-1(7-36);
Arg.sup.26Lys.sup.27,34-bis-(Glyc-AHex)-GLP-1(7-37);
Arg.sup.34Lys.sup.27,26-bis-(Glyc-AHex)-GLP-1(7-37);
Arg.sup.26Lys.sup.27,34-bis-(Glyc-AHex)-GLP-1(7-38);
Arg.sup.34Lys.sup.27,26-bis-(Glyc-AHex)-GLP-1(7-38);
Arg.sup.26Lys.sup.27,34-bis-(Glyc-AHex)-GLP-1(7-39);
Arg.sup.34Lys.sup.27,26-bis-(Glyc-AHex)-GLP-1(7-39);
Gly.sup.8Lys.sup.26,34-bis-(Glyc-AHex)-GLP-1(7-36);
Gly.sup.8Lys.sup.26,34-bis-(Glyc-AHex)-GLP-1(7-37);
Gly.sup.8Lys.sup.26,34-bis-(Glyc-AHex)-GLP-1(7-38);
Gly.sup.8Lys.sup.26,34-bis-(Glyc-AHex)-GLP-1(7-39)
Gly.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glyc-AHex)-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glyc-AHex)-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glyc-AHex)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glyc-AHex)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34,37-bis-(Glyc-AHex)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26,37-bis-(Glyc-AHex)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34,38-bis-(Glyc-AHex)-GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.26,38-bis-(Glyc-AHex)-GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Glyc-AHex)-GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.34,39-bis-(Glyc-AHex)-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.26,39-bis-(Glyc-AHex)-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Glyc-AHex)-GLP-1(7-39);
[1222] Val.sup.8Lys.sup.26,34-bis-(Glyc-AHex)-GLP-1(7-36);
Val.sup.8Lys.sup.26,34-bis-(Glyc-AHex)-GLP-1(7-37);
Val.sup.8Lys.sup.26,34-bis-(Glyc-AHex)-GLP-1(7-38);
Val.sup.8Lys.sup.26,34-bis-(Glyc-AHex)-GLP-1(7-39)
Val.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glyc-AHex)-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glyc-AHex)-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glyc-AHex)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glyc-AHex)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34,37-bis-(Glyc-AHex)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26,37-bis-(Glyc-AHex)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34,38-bis-(Glyc-AHex)-GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.26,38-bis-(Glyc-AHex)-GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Glyc-AHex)-GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.34,39-bis-(Glyc-AHex)-GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.26,39-bis-(Glyc-AHex)-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Glyc-AHex)-GLP-1(7-39);
[1223] Ser.sup.8Lys.sup.26,34-bis-(Glyc-AHex)-GLP-1(7-36);
Ser.sup.8Lys.sup.26,34-bis-(Glyc-AHex)-GLP-1(7-37);
Ser.sup.8Lys.sup.26,34-bis-(Glyc-AHex)-GLP-1(7-38);
Ser.sup.8Lys.sup.26,34-bis-(Glyc-AHex)-GLP-1(7-39)
Ser.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glyc-AHex)-GLP-1(7-36);
Ser.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glyc-AHex)-GLP-1(7-36);
Ser.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glyc-AHex)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glyc-AHex)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34,37-bis-(Glyc-AHex)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26,37-bis-(Glyc-AHex)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34,38-bis-(Glyc-AHex)-GLP-1(7-38);
Ser.sup.8Arg.sup.34Lys.sup.26,38-bis-(Glyc-AHex)-GLP-1(7-38);
Ser.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Glyc-AHex)-GLP-1(7-38);
Ser.sup.8Arg.sup.26Lys.sup.34,39-bis-(Glyc-AHex)-GLP-1(7-39);
Ser.sup.8Arg.sup.34Lys.sup.26,39-bis-(Glyc-AHex)-GLP-1(7-39);
Ser.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Glyc-AHex)-GLP-1(7-39);
[1224] Thr.sup.8Lys.sup.26,34-bis-(Glyc-AHex)-GLP-1(7-36);
Thr.sup.8Lys.sup.26,34-bis-(Glyc-AHex)-GLP-1(7-37);
Thr.sup.8Lys.sup.26,34-bis-(Glyc-AHex)-GLP-1(7-38);
Thr.sup.8Lys.sup.26,34-bis-(Glyc-AHex)-GLP-1(7-39)
Thr.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glyc-AHex)-GLP-1(7-36);
Thr.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glyc-AHex)-GLP-1(7-36);
Thr.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glyc-AHex)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glyc-AHex)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34,37-bis-(Glyc-AHex)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26,37-bis-(Glyc-AHex)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34,38-bis-(Glyc-AHex)-GLP-1(7-38);
Thr.sup.8Arg.sup.34Lys.sup.26,38-bis-(Glyc-AHex)-GLP-1(7-38);
Thr.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Glyc-AHex)-GLP-1(7-38);
Thr.sup.8Arg.sup.26Lys.sup.34,39-bis-(Glyc-AHex)-GLP-1(7-39);
Thr.sup.8Arg.sup.34Lys.sup.26,39-bis-(Glyc-AHex)-GLP-1(7-39);
Thr.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Glyc-AHex)-GLP-1(7-39);
[1225] Lys.sup.26,34-bis-(Glyc-AOct)-GLP-1(7-36);
Lys.sup.26,34-bis-(Glyc-AOct)-GLP-1(7-37);
Lys.sup.26,34-bis-(Glyc-AOct)-GLP-1(7-38);
Lys.sup.26,34-bis-(Glyc-AOct)-GLP-1(7-39)
Arg.sup.26Lys.sup.34,36-bis-(Glyc-AOct)-GLP-1(7-36);
Arg.sup.34Lys.sup.26,36-bis-(Glyc-AOct)-GLP-1(7-36);
Arg.sup.26Lys.sup.34,36-bis-(Glyc-AOct)-GLP-1(7-37);
Arg.sup.34Lys.sup.26,36-bis-(Glyc-AOct)-GLP-1(7-37);
Arg.sup.26Lys.sup.34,37-bis-(Glyc-AOct)-GLP-1(7-37);
Arg.sup.34Lys.sup.26,37-bis-(Glyc-AOct)-GLP-1(7-37);
Arg.sup.26Lys.sup.34,39-bis-(Glyc-AOct)-GLP-1(7-39);
Arg.sup.34Lys.sup.26,39-bis-(Glyc-AOct)-GLP-1(7-39);
Arg.sup.26,34Lys.sup.36,39-bis-(Glyc-AOct)-GLP-1(7-39);
[1226] Arg.sup.26Lys.sup.18,34-bis-(Glyc-AOct)-GLP-1(7-36);
Arg.sup.34Lys.sup.18,26-bis-(Glyc-AOct)-GLP-1(7-36);
Arg.sup.26Lys.sup.18,34-bis-(Glyc-AOct)-GLP-1(7-37);
Arg.sup.34Lys.sup.18,26-bis-(Glyc-AOct)-GLP-1(7-37);
Arg.sup.26Lys.sup.18,34-bis-(Glyc-AOct)-GLP-1(7-38);
Arg.sup.34Lys.sup.18,26-bis-(Glyc-AOct)-GLP-1(7-38);
Arg.sup.26Lys.sup.18,34-bis-(Glyc-AOct)-GLP-1(7-39);
Arg.sup.34Lys.sup.18,26-bis-(Glyc-AOct)-GLP-1(7-39);
Arg.sup.26Lys.sup.23,34-bis-(Glyc-AOct)-GLP-1(7-36);
Arg.sup.34Lys.sup.23,26-bis-(Glyc-AOct)-GLP-1(7-36);
Arg.sup.26Lys.sup.23,34-bis-(Glyc-AOct)-GLP-(7-37);
Arg.sup.34Lys.sup.23,26-bis-(Glyc-AOct)-GLP-1(7-37);
Arg.sup.26Lys.sup.23,34-bis-(Glyc-AOct)-GLP-1(7-38);
Arg.sup.34Lys.sup.23,26-bis-(Glyc-AOct)-GLP-1(7-38);
Arg.sup.26Lys.sup.23,34-bis-(Glyc-AOct)-GLP-1(7-39);
Arg.sup.34Lys.sup.23,26-bis-(Glyc-AOct)-GLP-1(7-39);
Arg.sup.26Lys.sup.27,34-bis-(Glyc-AOct)-GLP-1(7-36);
Arg.sup.34Lys.sup.27,26-bis-(Glyc-AOct)-GLP-1(7-36);
Arg.sup.26Lys.sup.27,34-bis-(Glyc-AOct)-GLP-1(7-37);
Arg.sup.34Lys.sup.27,26-bis-(Glyc-AOct)-GLP-1(7-37);
Arg.sup.26Lys.sup.27,34-bis-(Glyc-AOct)-GLP-1(7-38);
Arg.sup.34Lys.sup.27,26-bis-(Glyc-AOct)-GLP-1(7-38);
Arg.sup.26Lys.sup.27,34-bis-(Glyc-AOct)-GLP-1(7-39);
Arg.sup.34Lys.sup.27,26-bis-(Glyc-AOct)-GLP-1(7-39);
Gly.sup.8Lys.sup.26,34-bis-(Glyc-AOct)-GLP-1(7-36);
Gly.sup.8Lys.sup.26,34-bis-(Glyc-AOct)-GLP-1(7-37);
Gly.sup.8Lys.sup.26,34-bis-(Glyc-AOct)-GLP-1(7-38);
Gly.sup.8Lys.sup.26,34-bis-(Glyc-AOct)-GLP-1(7-39)
Gly.sup.1Arg.sup.26Lys.sup.34,36-bis-(Glyc-AOct)-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glyc-AOct)-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glyc-AOct)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glyc-AOct)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34,37-bis-(Glyc-AOct)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26,37-bis-(Glyc-AOct)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34,38-bis-(Glyc-AOct)-GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.26,38-bis-(Glyc-AOct)-GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Glyc-AOct)-GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.34,39-bis-(Glyc-AOct)-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.26,39-bis-(Glyc-AOct)-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Glyc-AOct)-GLP-1(7-39);
[1227] Val.sup.8Lys.sup.26,34-bis-(Glyc-AOct)-GLP-1(7-36);
Val.sup.8Lys.sup.26,34-bis-(Glyc-AOct)-GLP-1(7-37);
Val.sup.8Lys.sup.26,34-bis-(Glyc-AOct)-GLP-1(7-38);
Val.sup.8Lys.sup.26,34-bis-(Glyc-AOct)-GLP-1(7-39)
Val.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glyc-AOct)-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glyc-AOct)-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glyc-AOct)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glyc-AOct)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34,37-bis-(Glyc-AOct)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26,37-bis-(Glyc-AOct)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34,38-bis-(Glyc-AOct)-GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.26,38-bis-(Glyc-AOct)-GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Glyc-AOct)-GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.34,39-bis-(Glyc-AOct)-GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.26,39-bis-(Glyc-AOct)-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Glyc-AOct)-GLP-1(7-39);
[1228] Ser.sup.8Lys.sup.26,34-bis-(Glyc-AOct)-GLP-1(7-36);
Ser.sup.8Lys.sup.26,34-bis-(Glyc-AOct)-GLP-1(7-37);
Ser.sup.8Lys.sup.26,34-bis-(Glyc-AOct)-GLP-1(7-38);
Ser.sup.8Lys.sup.26,34-bis-(Glyc-AOct)-GLP-1(7-39)
Ser.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glyc-AOct)-GLP-1(7-36);
Ser.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glyc-AOct)-GLP-1(7-36);
Ser.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glyc-AOct)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glyc-AOct)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34,37-bis-(Glyc-AOct)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26,37-bis-(Glyc-AOct)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34,38-bis-(Glyc-AOct)-GLP-1(7-38);
Ser.sup.8Arg.sup.34Lys.sup.26,38-bis-(Glyc-AOct)-GLP-1(7-38);
Ser.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Glyc-AOct)-GLP-1(7-38);
Ser.sup.8Arg.sup.26Lys.sup.34,39-bis-(Glyc-AOct)-GLP-1(7-39);
Ser.sup.8Arg.sup.34Lys.sup.26,39-bis-(Glyc-AOct)-GLP-1(7-39);
Ser.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Glyc-AOct)-GLP-1(7-39);
[1229] Thr.sup.8Lys.sup.26,34-bis-(Glyc-AOct)-GLP-1(7-36);
Thr.sup.8Lys.sup.26,34-bis-(Glyc-AOct)-GLP-1(7-37);
Thr.sup.8Lys.sup.26,34-bis-(Glyc-AOct)-GLP-1(7-38);
Thr.sup.8Lys.sup.26,34-bis-(Glyc-AOct)-GLP-1(7-39)
Thr.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glyc-AOct)-GLP-1(7-36);
Thr.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glyc-AOct)-GLP-1(7-36);
Thr.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glyc-AOct)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glyc-AOct)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34,37-bis-(Glyc-AOct)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26,37-bis-(Glyc-AOct)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34,38-bis-(Glyc-AOct)-GLP-1(7-38);
Thr.sup.8Arg.sup.34Lys.sup.26,38-bis-(Glyc-AOct)-GLP-1(7-38);
Thr.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Glyc-AOct)-GLP-1(7-38);
Thr.sup.8Arg.sup.26Lys.sup.34,39-bis-(Glyc-AOct)-GLP-1(7-39);
Thr.sup.8Arg.sup.34Lys.sup.26,39-bis-(Glyc-AOct)-GLP-1(7-39);
Thr.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Glyc-AOct)-GLP-1(7-39);
[1230] Lys.sup.26,34-bis-(Glyc-ALit)-GLP-1(7-36);
Lys.sup.26,34-bis-(Glyc-ALit)-GLP-1(7-37);
Lys.sup.26,34-bis-(Glyc-ALit)-GLP-1(7-38);
Lys.sup.34-bis-(Glyc-ALit)-GLP-1(7-39)
Arg.sup.26Lys.sup.34,36-bis-(Glyc-ALit)-GLP-1(7-36);
Arg.sup.34Lys.sup.26,36-bis-(Glyc-ALit)-GLP-1(7-36);
Arg.sup.26Lys.sup.34,36-bis-(Glyc-ALit)-GLP-1(7-37);
Arg.sup.34Lys.sup.26,36-bis-(Glyc-ALit)-GLP-1(7-37);
Arg.sup.26Lys.sup.34,37-bis-(Glyc-ALit)-GLP-1(7-37);
Arg.sup.34Lys.sup.26,37-bis-(Glyc-ALit)-GLP-1(7-37);
Arg.sup.26Lys.sup.34,39-bis-(Glyc-ALit)-GLP-1(7-39);
Arg.sup.34Lys.sup.26,39-bis-(Glyc-ALit)-GLP-1(7-39);
Arg.sup.26,34Lys.sup.36,39-bis-(Glyc-ALit)-GLP-1(7-39);
[1231] Arg.sup.26Lys.sup.18,34-bis-(Glyc-ALit)-GLP-1(7-36);
Arg.sup.34Lys.sup.18,26-bis-(Glyc-ALit)-GLP-1(7-36);
Arg.sup.26Lys.sup.18,34-bis-(Glyc-ALit)-GLP-1(7-37);
Arg.sup.34Lys.sup.18,26-bis-(Glyc-ALit)-GLP-1(7-37);
Arg.sup.26Lys.sup.18,34-bis-(Glyc-ALit)-GLP-1(7-38);
Arg.sup.34Lys.sup.18,26-bis-(Glyc-ALit)-GLP-1(7-38);
Arg.sup.26Lys.sup.18,34-bis-(Glyc-ALit)-GLP-1(7-39);
Arg.sup.34Lys.sup.18,26-bis-(Glyc-ALit)-GLP-1(7-39);
Arg.sup.26Lys.sup.23,34-bis-(Glyc-ALit)-GLP-1(7-36);
Arg.sup.34Lys.sup.23,26-bis-(Glyc-ALit)-GLP-1(7-36);
Arg.sup.26Lys.sup.23,34-bis-(Glyc-ALit)-GLP-1(7-37);
Arg.sup.34Lys.sup.23,26-bis-(Glyc-ALit)-GLP-1(7-37);
Arg.sup.26Lys.sup.23,34-bis-(Glyc-ALit)-GLP-1(7-38);
Arg.sup.34Lys.sup.23,26-bis-(Glyc-ALit)-GLP-1(7-38);
Arg.sup.26Lys.sup.23,34-bis-(Glyc-ALit)-GLP-1(7-39);
Arg.sup.34Lys.sup.23,26-bis-(Glyc-ALit)-GLP-1(7-39);
Arg.sup.26Lys.sup.27,34-bis-(Glyc-ALit)-GLP-1(7-36);
Arg.sup.34Lys.sup.27,26-bis-(Glyc-ALit)-GLP-1(7-36);
Arg.sup.26Lys.sup.27,34-bis-(Glyc-A-Lit)-GLP-1(7-37);
Arg.sup.34Lys.sup.27,26-bis-(Glyc-ALit)-GLP-1(7-37);
Arg.sup.26Lys.sup.27,34-bis-(Glyc-ALit)-GLP-1(7-38);
Arg.sup.34Lys.sup.27,26-bis-(Glyc-ALit)-GLP-1(7-38);
Arg.sup.26Lys.sup.27,34-bis-(Glyc-ALit)-GLP-1(7-39);
Arg.sup.34Lys.sup.27,26-bis-(Glyc-ALit)-GLP-1(7-39);
Gly.sup.8Lys.sup.26,34-bis-(Glyc-ALit)-GLP-1(7-36);
Gly.sup.8Lys.sup.26,34-bis-(Glyc-ALit)-GLP-1(7-37);
Gly.sup.8Lys.sup.26,34-bis-(Glyc-ALit)-GLP-1(7-38);
Gly.sup.8Lys.sup.26,34-bis-(Glyc-ALit)-GLP-1(7-39)
Gly.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glyc-ALit)-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glyc-ALit)-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glyc-ALit)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glyc-ALit)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34,37-bis-(Glyc-ALit)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26,37-bis-(Glyc-ALit)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34,38-bis-(Glyc-ALit)-GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.26,38(38-bis-(Glyc-ALit)-GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Glyc-ALit)-GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.34,39-bis-(Glyc-ALit)-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.26,39-bis-(Glyc-ALit)-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Glyc-ALit)-GLP-1(7-39);
Val.sup.8Lys.sup.26,34-bis-(Glyc-ALit)-GLP-1(7-36);
Val.sup.8Gly.sup.26,34-bis-(Glyc-ALit)-GLP-1(7-37);
Val.sup.8Lys.sup.26,34-bis-(Glyc-ALit)-GLP-1(7-38);
Val.sup.8Lys.sup.26,34-bis-(Glyc-ALit)-GLP-1(7-39)
Val.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glyc-ALit)-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glyc-ALit)-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glyc-ALit)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glyc-ALit)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34,37-bis-(Glyc-ALit)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26,37-bis-(Glyc-ALit)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34,38-bis-(Glyc-ALit)-GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.26,38-bis-(Glyc-ALit)-GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Glyc-ALit)-GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.34,39-bis-(Glyc-ALit)-GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.26,39-bis-(Glyc-ALit)-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Glyc-ALit)-GLP-1(7-39);
Ser.sup.8Lys.sup.26,34-bis-(Glyc-ALit)-GLP-1(7-36);
Ser.sup.8Lys.sup.26,34-bis-(Glyc-ALit)-GLP-1(7-37);
Ser.sup.8Lys.sup.26,34-bis-(Glyc-ALit)-GLP-1(7-38);
Ser.sup.8Lys.sup.26,34-bis-(Glyc-ALit)-GLP-1(7-39)
Ser.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glyc-ALit)-GLP-1(7-36);
Ser.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glyc-ALit)-GLP-1(7-36);
Ser.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glyc-ALit)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glyc-ALit)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34,37-bis-(Glyc-ALit)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26,37-bis-(Glyc-ALit)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34,38-bis-(Glyc-ALit)-GLP-1(7-38);
Ser.sup.8Arg.sup.34Lys.sup.26,38-bis-(Glyc-ALit)-GLP-1(7-38);
Ser.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(Glyc-ALit)-GLP-1(7-38);
Ser.sup.8Arg.sup.26Lys.sup.34,39-bis-(Glyc-ALit)-GLP-1(7-39);
Ser.sup.8Arg.sup.34Lys.sup.26,39-bis-(Glyc-ALit)-GLP-1(7-39);
Ser.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Glyc-ALit)-GLP-1(7-39);
Thr.sup.8Lys.sup.26,34-bis-(Glyc-ALit)-GLP-1(7-36);
Thr.sup.8Lys.sup.26,34-bis-(Glyc-ALit)-GLP-1(7-37);
Thr.sup.8Lys.sup.26,34-bis-(Glyc-ALit)-GLP-1(7-38);
Thr.sup.8Lys.sup.26,34-bis-(Glyc-ALit)-GLP-1(7-39)
Thr.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glyc-ALit)-GLP-1(7-36);
Thr.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glyc-ALit)-GLP-1(7-36);
Thr.sup.8Arg.sup.26Lys.sup.34,36-bis-(Glyc-ALit)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26,36-bis-(Glyc-ALit)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34,37-bis-(Glyc-ALit)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26,37-bis-(Glyc-ALit)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34,38-bis-(Glyc-ALit)-GLP-1(7-38);
Thr.sup.8Arg.sup.34Lys.sup.26,38-bis-(Glyc-ALit)-GLP-1(7-38);
Thr.sup.8Arg.sup.26,34-Lys.sup.36,38-bis-(Glyc-ALit)-GLP-1(7-38);
Thr.sup.8Arg.sup.26Lys.sup.34,39-bis-(Glyc-ALit)-GLP-1(7-39);
Thr.sup.8Arg.sup.34Lys.sup.26,39-bis-(Glyc-ALit)-GLP-1(7-39);
Thr.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(Glyc-ALit)-GLP-1(7-39);
Lys.sup.26,34-bis-(GAB-GDod)-GLP-1(7-36);
Lys.sup.26,34-bis-(GAB-GDod)-GLP-1(7-37);
Lys.sup.26,34-bis-(GAB-GDod)-GLP-1(7-38);
Lys.sup.26,34-bis-(GAB-GDod)-GLP-1(7-39)
Arg.sup.26Lys.sup.34,36-bis-(GAB-GDod)-GLP-1(7-36);
Arg.sup.34Lys.sup.26,36-bis-(GAB-GDod)-GLP-1(7-36);
Arg.sup.26Lys.sup.34,36-bis-(GAB-GDod)-GLP-1(7-37);
Arg.sup.34Lys.sup.26,36-bis-(GAB-GDod)-GLP-1(7-37);
Arg.sup.26Lys.sup.34,37-bis-(GAB-GDod)-GLP-1(7-37);
Arg.sup.34Lys.sup.26,37-bis-(GAB-GDod)-GLP-1(7-37);
Arg.sup.26Lys.sup.34,39-bis-(GAB-GDod)-GLP-1(7-39);
Arg.sup.34Lys.sup.26,39-bis-(GAB-GDod)-GLP-1(7-39);
Arg.sup.26,34Lys.sup.36,39-bis-(GAB-GDod)-GLP-1(7-39);
[1232] Arg.sup.26Lys.sup.18,34-bis-(GAB-GDod)-GLP-1(7-36);
Arg.sup.34Lys.sup.18,26-bis-(GAB-GDod)-GLP-1(7-36);
Arg.sup.26Lys.sup.18,34-bis-(GAB-GDod)-GLP-1(7-37);
Arg.sup.34Lys.sup.18,26-bis-(GAB-GDod)-GLP-1(7-37);
Arg.sup.26Lys.sup.18,34-bis-(GAB-GDod)-GLP-1(7-38);
Arg.sup.34Lys.sup.18,26-bis-(GAB-GDod)-GLP-1(7-38);
Arg.sup.26Lys.sup.18,34-bis-(GAB-GDod)-GLP-1(7-39);
Arg.sup.34Lys.sup.18,26-bis-(GAB-GDod)-GLP-1(7-39);
Arg.sup.26Lys.sup.23,34-bis-(GAB-GDod)-GLP-1(7-36);
Arg.sup.34Lys.sup.23,26-bis-(GAB-GDod)-GLP-1(7-36);
Arg.sup.26Lys.sup.23,34-bis-(GAB-GDod)-GLP-1(7-37);
Arg.sup.34Lys.sup.23,26-bis-(GAB-GDod)-GLP-1(7-37);
Arg.sup.26Lys.sup.23,34-bis-(GAB-GDod)-GLP-1(7-38);
Arg.sup.34Lys.sup.23,26-bis-(GAB-GDod)-GLP-1(7-38);
Arg.sup.26Lys.sup.23,34-bis-(GAB-GDod)-GLP-1(7-39);
Arg.sup.34Lys.sup.23,26-bis-(GAB-GDod)-GLP-1(7-39);
Arg.sup.26Lys.sup.27,34-bis-(GAB-GDod)-GLP-1(7-36);
Arg.sup.34Lys.sup.27,26-bis-(GAB-GDod)-GLP-1(7-36);
Arg.sup.26Lys.sup.27,34-bis-(GAB-GDod)-GLP-1(7-37);
Arg.sup.34Lys.sup.27,26-bis-(GAB-GDod)-GLP-1(7-37);
Arg.sup.26Lys.sup.27,34-bis-(GAB-GDod)-GLP-1(7-38);
Arg.sup.34Lys.sup.27,26-bis-(GAB-GDod)-GLP-1(7-38);
Arg.sup.26Lys.sup.27,34-bis-(GAB-GDod)-GLP-1(7-39);
Arg.sup.34Lys.sup.27,26-bis-(GAB-GDod)-GLP-1(7-39);
Gly.sup.8Lys.sup.27,34-bis-(GAB-GDod)-GLP-1(7-36);
Gly.sup.8Lys.sup.26,34-bis-(GAB-GDod)-GLP-1(7-37);
Gly.sup.8Lys.sup.26,34-bis-(GAB-GDod)-GLP-1(7-38);
Gly.sup.8Lys.sup.26,34-bis-(GAB-GDod)-GLP-1(7-39)
Gly.sup.8Arg.sup.26Lys.sup.34,36-bis-(GAB-GDod)-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.26,34-bis-(GAB-GDod)-GLP-1(7-39);
Gly.sup.8Arg.sup.26Lys.sup.34,36-bis-(GAB-GDod)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26,36-bis-(GAB-GDod)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34,37-bis-(GAB-GDod)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26,37-bis-(GAB-GDod)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34,38-bis-(GAB-GDod)-GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.26,38-bis-(GAB-GDod)-GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(GAB-GDod)-GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.34,39-bis-(GAB-GDod)-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.26,39-bis-(GAB-GDod)-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(GAB-GDod)-GLP-1(7-39);
[1233] Val.sup.8Lys.sup.26,34-bis-(GAB-GDod)-GLP-1(7-36);
Val.sup.8Lys.sup.26,34-bis-(GAB-GDod)-GLP-1(7-37);
Val.sup.8Lys.sup.26,34-bis-(GAB-GDod)-GLP-1(7-38);
Val.sup.8Lys.sup.26,34-bis-(GAB-GDod)-GLP-1(7-39);
Val.sup.8Arg.sup.26Lys.sup.34,36-bis-(GAB-GDod)-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.26,36-bis-(GAB-GDod)-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.34,36-bis-(GAB-GDod)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26,36-bis-(GAB-GDod)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34,37-bis-(GAB-GDod)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26,37-bis-(GAB-GDod)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34,38-bis-(GAB-GDod)-GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.26,38-bis-(GAB-GDod)-GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.63,38-bis-(GAB-GDod)-GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.34,39-bis-(GAB-GDod)-GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.26,39-bis-(GAB-GDod)-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(GAB-GDod)-GLP-1(7-39);
[1234] Ser.sup.8Lys.sup.26,34-bis-(GAB-GDod)-GLP-1(7-36);
Ser.sup.8Lys.sup.26,34-bis-(GAB-GDod)-GLP-1(7-37);
Ser.sup.8Lys.sup.26,34-bis-(GAB-GDod)-GLP-1(7-38);
Ser.sup.8Lys.sup.26,34-bis-(GAB-GDod)-GLP-1(7-39)
Ser.sup.8Arg.sup.26Lys.sup.34,36-bis-(GAB-GDod)-GLP-1(7-36);
Ser.sup.8Arg.sup.34Lys.sup.26,36-bis-(GAB-GDod)-GLP-1(7-36);
Ser.sup.8Arg.sup.26Lys.sup.34,36-bis-(GAB-GDod)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26,36-bis-(GAB-GDod)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34,37-bis-(GAB-GDod)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26,37-bis-(GAB-GDod)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34,38-bis-(GAB-GDod)-GLP-1(7-38);
Ser.sup.8Arg.sup.34Lys.sup.26,38-bis-(GAB-GDod)-GLP-1(7-38);
Ser.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(GAB-GDod)-GLP-1(7-38);
Ser.sup.8Arg.sup.26Lys.sup.34,39-bis-(GAB-GDod)-GLP-1(7-39);
Ser.sup.8Arg.sup.34Lys.sup.26,39-bis-(GAB-GDod)-GLP-1(7-39);
Ser.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(GAB-GDod)-GLP-1(7-39);
[1235] Thr.sup.8Lys.sup.26,34-bis-(GAB-GDod)-GLP-1(7-36);
Thr.sup.8Lys.sup.26,34-bis-(GAB-GDod)-GLP-1(7-37);
Thr.sup.8Lys.sup.26,34-bis-(GAB-GDod)-GLP-1(7-38);
Thr.sup.8Lys.sup.26,34-bis-(GAB-GDod)-GLP-1(7-39)
Thr.sup.8Arg.sup.26Lys.sup.34,36-bis-(GAB-GDod)-GLP-1(7-36);
Thr.sup.8Arg.sup.34Lys.sup.26,36-bis-(GAB-GDod)-GLP-1(7-36);
Thr.sup.8Arg.sup.26Lys.sup.34,36-bis-(GAB-GDod)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26,36-bis-(GAB-GDod)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34,37-bis-(GAB-GDod)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26,37-bis-(GAB-GDod)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34,38-bis-(GAB-GDod)-GLP-1(7-38);
Thr.sup.8Arg.sup.34Lys.sup.26,38-bis-(GAB-GDod)-GLP-1(7-38);
Thr.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(GAB-GDod)-GLP-1(7-38);
Thr.sup.8Arg.sup.26Lys.sup.34,39-bis-(GAB-GDod)-GLP-1(7-39);
Thr.sup.8Arg.sup.34Lys.sup.26,39-bis-(GAB-GDod)-GLP-1(7-39);
Thr.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(GAB-GDod)-GLP-1(7-39);
[1236] Lys.sup.26,34-bis-(GAB-GTet)-GLP-1(7-36);
Lys.sup.26,34-bis-(GAB-GTet)-GLP-1(7-37);
Lys.sup.26,34-bis-(GAB-GTet)-GLP-1(7-38);
Lys.sup.26,34-bis-(GAB-GTet)-GLP-1(7-39)
Arg.sup.26Lys.sup.34,36-bis-(GAB-GTet)-GLP-1(7-36);
Arg.sup.34Lys.sup.26,36-bis-(GAB-GTet)-GLP-1(7-36);
Arg.sup.26Lys.sup.34,36-bis-(GAB-GTet)-GLP-1(7-37);
Arg.sup.34Lys.sup.26,36-bis-(GAB-GTet)-GLP-1(7-37);
Arg.sup.26Lys.sup.34,37-bis-(GAB-GTet)-GLP-1(7-37);
Arg.sup.34Lys.sup.26,37-bis-(GAB-GTet)-GLP-1(7-37);
Arg.sup.26Lys.sup.34,39-bis-(GAB-GTet)-GLP-1(7-39);
Arg.sup.34Lys.sup.26,39-bis-(GAB-GTet)-GLP-1(7-39);
Arg.sup.26,34Lys.sup.36,39-bis-(GAB-GTet)-GLP-1(7-39);
[1237] Arg.sup.26Lys.sup.18,34-bis-(GAB-GTet)-GLP-1(7-36);
Arg.sup.34Lys.sup.18,26-bis-(GAB-GTet)-GLP-1(7-36);
Arg.sup.26Lys.sup.18,34-bis-(GAB-GTet)-GLP-1(7-37);
Arg.sup.34Lys.sup.18,26-bis-(GAB-GTet)-GLP-1(7-37);
Arg.sup.26Lys.sup.18,34-bis-(GAB-GTet)-GLP-1(7-38);
Arg.sup.34Lys.sup.18,26-bis-(GAB-GTet)-GLP-1(7-38);
Arg.sup.26Lys.sup.18,34-bis-(GAB-GTet)-GLP-1(7-39);
Arg.sup.34Lys.sup.18,26-bis-(GAB-GTet)-GLP-1(7-39);
Arg.sup.26Lys.sup.23,34-bis-(GAB-GTet)-GLP-1(7-36);
Arg.sup.34Lys.sup.23,26-bis-(GAB-GTet)-GLP-1(7-36);
Arg.sup.26Lys.sup.23,34-bis-(GAB-GTet)-GLP-1(7-37);
Arg.sup.34Lys.sup.23,26-bis-(GAB-GTet)-GLP-1(7-37);
Arg.sup.26Lys.sup.23,34-bis-(GAB-GTet)-GLP-1(7-38);
Arg.sup.34Lys.sup.23,26-bis-GTet)-GLP-1(7-38);
Arg.sup.26Lys.sup.23,34-bis-(GAB-GTet)-GLP-1(7-39);
Arg.sup.23,26-bis-(GAB-GTet)-GLP-1(7-39);
Arg.sup.26Lys.sup.27,34-bis-(GAB-GTet)-GLP-1(7-36);
Arg.sup.34Lys.sup.27,26-bis-(GAB-GTet)-GLP-1(7-36);
Arg.sup.26Lys.sup.27,34-bis-(GAB-GTet)-GLP-1(7-37);
Arg.sup.34Lys.sup.27,26-bis-(GAB-GTet)-GLP-1(7-37);
Arg.sup.26Lys.sup.27,34-bis-(GAB-GTet)-GLP-1(7-38);
Arg.sup.34Lys.sup.27,26-bis-(GAB-G-GTet)-GLP-1(7-38);
Arg.sup.26Lys.sup.27,34-bis-(GAB-GTet)-GLP-1(7-39);
Arg.sup.34Lys.sup.27,26-bis-(GAB-GTet)-GLP-1(7-39);
Gly.sup.8Lys.sup.26,34-bis-(GAB-GTet)-GLP-1(7-36);
Gly.sup.8Lys.sup.26,34-bis-(GAB-GTet)-GLP-1(7-37);
Gly.sup.8Lys.sup.26,34-bis-(GAB-GTet)-GLP-1(7-38);
Gly.sup.8Lys.sup.26,34-bis-(GAB-GTet)-GLP-1(7-39)
Gly.sup.8Arg.sup.26Lys.sup.34,36-bis-(GAB-GTet)-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.26,36-bis-(GAB-GTet)-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.34,36-bis-(GAB-GTet)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26,36-bis-(GAB-GTet)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34,37-bis-(GAB-GTet)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26,37-bis-(GAB-GTet)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34,38-bis-(GAB-GTet)-GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.26,38-bis-(GAB-GTet)-GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(GAB-GTet)-GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.34,39-bis-(GAB-GTet)-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.26,39-bis-(GAB-GTet)-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(GAB-GTet)-GLP-1(7-39);
[1238] Val.sup.8Lys.sup.26,34-bis-(GAB-GTet)-GLP-1(7-36);
Val.sup.8Lys.sup.26,34-bis-(GAB-GTet)-GLP-1(7-37);
Val.sup.8Lys.sup.26,34-bis-(GAB-GTet)-GLP-1(7-38);
Val.sup.8Lys.sup.26,34-bis-(GAB-GTet)-GLP-1(7-39)
Val.sup.8Arg.sup.26Lys.sup.34,36-bis-(GAB-GTet)-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.26,36-bis-(GAB-GTet)-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.34,36-bis-(GAB-GTet)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26,36-bis-(GAB-GTet)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34,37-bis-(GAB-GTet)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26,37-bis-(GAB-GTet)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34,38-bis-(GAB-GTet)-GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.26,38-bis-(GAB-GTet)-GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(GAB-GTet)-GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.34,39-bis-(GAB-GTet)-GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.26,39-bis-(GAB-GTet)-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(GAB-GTet)-GLP-1(7-39);
[1239] Ser.sup.8Lys.sup.26,34-bis-(GAB-GTet)-GLP-1(7-36);
Ser.sup.8Lys.sup.26,34-bis-(GAB-GTet)-GLP-1(7-37);
Ser.sup.8Lys.sup.26,34-bis-(GAB-GTet)-GLP-1(7-38);
Ser.sup.8Lys.sup.26,34-bis-(GAB-GTet)-GLP-1(7-39)
Ser.sup.8Arg.sup.26Lys.sup.34,36-bis-(GAB-GTet)-GLP-1(7-36);
Ser.sup.8Arg.sup.34Lys.sup.26,36-bis-(GAB-GTet)-GLP-1(7-36);
Ser.sup.8Arg.sup.26Lys.sup.34,36-bis-(GAB-GTet)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26,36-bis-(GAB-GTet)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34,37-bis-(GAB-GTet)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26,37-bis-(GAB-GTet)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34,38-bis-(GAB-GTet)-GLP-1(7-38);
Ser.sup.8Arg.sup.34Lys.sup.26,38-bis-(GAB-GTet)-GLP-1(7-38);
Ser.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(GAB-GTet)-GLP-1(7-38);
Ser.sup.8Arg.sup.26Lys.sup.34,39-bis-(GAB-GTet)-GLP-1(7-39);
Ser.sup.8Arg.sup.34Lys.sup.26,39-bis-(GAB-GTet)-GLP-1(7-39);
Ser.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(GAB-GTet)-GLP-1(7-39);
[1240] Thr.sup.8Lys.sup.26,34-bis-(GAB-GTet)-GLP-1(7-36);
Thr.sup.8Lys.sup.26,34-bis-(GAB-GTet)-GLP-1(7-37);
Thr.sup.8Lys.sup.26,34-bis-(GAB-GTet)-GLP-1(7-38);
Thr.sup.8Lys.sup.26,34-bis-(GAB-GTet)-GLP-1(7-39)
Thr.sup.8Arg.sup.26Lys.sup.34,36-bis-(GAB-GTet)-GLP-1(7-36);
Thr.sup.8Arg.sup.34Lys.sup.26,36-bis-(GAB-GTet)-GLP-1(7-36);
Thr.sup.8Arg.sup.26Lys.sup.34,36-bis-(GAB-GTet)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26,36-bis-(GAB-GTet)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34,37-bis-(GAB-GTet)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26,37-bis-(GAB-GTet)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34,38-bis-(GAB-GTet)-GLP-1(7-38);
Thr.sup.8Arg.sup.34Lys.sup.26,38-bis-(GAB-GTet)-GLP-1(7-38);
Thr.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(GAB-GTet)-GLP-1(7-38);
Thr.sup.8Arg.sup.26Lys.sup.34,39-bis-(GAB-GTet)-GLP-1(7-39);
Thr.sup.8Arg.sup.34Lys.sup.26,39-bis-(GAB-GTet)-GLP-1(7-39);
Thr.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(GAB-GTet)-GLP-1(7-39);
[1241] Lys.sup.26,34-bis-(GAB-GHex)-GLP-1(7-36);
Lys.sup.26,34-bis-(GAB-GHex)-GLP-1(7-37);
Lys.sup.26,34-bis-(GAB-GHex)-GLP-1(7-38);
Lys.sup.26,34-bis-(GAB-GHex)-GLP-1(7-39)
Arg.sup.26Lys.sup.34,36-bis-(GAB-GHex)-GLP-1(7-36);
Arg.sup.34Lys.sup.26,36-bis-(GAB-GHex)-GLP-1(7-36);
Arg.sup.26Lys.sup.34,36-(GAB-GHex)-GLP-1(7-37);
Arg.sup.34Lys.sup.26,36-bis-(GAB-GHex)-GLP-1(7-37);
Arg.sup.26Lys.sup.34,37-bis-(GAB-GHex)-GLP-1(7-37);
Arg.sup.34Lys.sup.26,37-bis-(GAB-GHex)-GLP-1(7-37);
Arg.sup.26Lys.sup.34,39-bis-(GAB-GHex)-GLP-1(7-39);
Arg.sup.34Lys.sup.26,39-bis-(GAB-GHex)-GLP-1(7-39);
Arg.sup.26,34Lys.sup.36,39-bis-(GAB-GHex)-GLP-1(7-39);
[1242] Arg.sup.26Lys.sup.18,34-bis-(GAB-GHex)-GLP-1(7-36);
Arg.sup.34Lys.sup.18,26-bis-(GAB-GHex)-GLP-1(7-36);
Arg.sup.26Lys.sup.18,34-bis-(GAB-GHex)-GLP-1(7-37);
Arg.sup.34Lys.sup.18,26-bis-(GAB-GHex)-GLP-1(7-37);
Arg.sup.26Lys.sup.18,34-bis-(GAB-GHex)-GLP-1(7-38);
Arg.sup.34Lys.sup.18,26-bis-(GAB-GHex)-GLP-1(7-38);
Arg.sup.26Lys.sup.18,34-bis-(GAB-GHex)-GLP-1(7-36);
Arg.sup.34Lys.sup.18,26-bis-(GAB-GHex)-GLP-1(7-36);
Arg.sup.26Lys.sup.23,34-bis-(GAB-GHex)-GLP-1(7-36);
Arg.sup.34Lys.sup.23,26-bis-(GAB-GHex)-GLP-1(7-36);
Arg.sup.26Lys.sup.23,34-bis-(GAB-GHex)-GLP-1(7-37);
Arg.sup.34Lys.sup.23,26-bis-(GAB-GHex)-GLP-1(7-37);
Arg.sup.26Lys.sup.23,34-bis-(GAB-GHex)-GLP-1(7-38);
Arg.sup.34Lys.sup.23,26-bis-(GAB-GHex)-GLP-1(7-38)
Arg.sup.26Lys.sup.23,34-bis-(GAB-GHex)-GLP-1(7-39);
Arg.sup.34Lys.sup.23,26-bis-(GAB-GHex)-GLP-1(7-39);
Arg.sup.26Lys.sup.27,34-bis-(GAB-GHex)-GLP-1(7-36);
Arg.sup.34Lys.sup.27,26-bis-(GAB-GHex)-GLP-1(7-36);
Arg.sup.26Lys.sup.27,34-bis-(GAB-GHex)-GLP-1(7-37);
Arg.sup.34Lys.sup.27,26-bis-(GAB-GHex)-GLP-1(7-37);
Arg.sup.26Lys.sup.27,34-bis-(GAB-GHex)-GLP-1(7-38);
Arg.sup.34Lys.sup.27,26-bis-(GAB-GHex)-GLP-1(7-38);
Arg.sup.26Lys.sup.27,34-bis-(GAB-GHex)-GLP-1(7-39);
Arg.sup.34Lys.sup.27,26-bis-(GAB-GHex)-GLP-1(7-39);
Gly.sup.8Lys.sup.26,34-bis-(GAB-GHex)-GLP-1(7-36);
Gly.sup.8Lys.sup.26,34-bis-(GAB-GHex)-GLP-1(7-37);
Gly.sup.8Lys.sup.26,34-bis-(GAB-GHex)-GLP-1(7-38);
Gly.sup.8Lys.sup.26,34-bis-(GAB-GHex)-GLP-1(7-39)
Gly.sup.8Arg.sup.26Lys.sup.34,36-bis-(GAB-GHex)-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.26,36-bis-(GAB-GHex)-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.34,36-bis-(GAB-GHex)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26,36-bis-(GAB-GHex)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34,37-bis-(GAB-GHex)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26,37-bis-(GAB-GHex)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34,38-bis-(GAB-GHex)-GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.26,38-bis-(GAB-GHex)-GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(GAB-GHex)-GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.34,39-bis-(GAB-GHex)-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.26,39-bis-(GAB-GHex)-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(GAB-GHex)-GLP-1(7-39);
[1243] Val.sup.8Lys.sup.26,34-bis-(GAB-GHex)-GLP-1(7-36);
Val.sup.8Lys.sup.26,34-bis-(GAB-GHex)-GLP-1(7-37);
Val.sup.8Lys.sup.26,34-bis-(GAB-GHex)-GLP-1(7-38);
Val.sup.8Lys.sup.26,34-bis-(GAB-GHex)-GLP-1(7-39)
Val.sup.8Arg.sup.26Lys.sup.34,36-bis-(GAB-GHex)-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.26,36-bis-(GAB-GHex)-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.34,36-bis-(GAB-GHex)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26,36-bis-(GAB-GHex)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34,37-bis-(GAB-GHex)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26,37-bis-(GAB-GHex)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34,38-bis-(GAB-GHex)-GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.26,38-bis-(GAB-GHex)-GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(GAB-GHex)-GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.34,39-bis-(GAB-GHex-GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.26,39-bis-(GAB-GHex)-GLP-1(7-39);
[1244]
Val.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(GAB-GHex)-GLP-1(7-39);
Ser.sup.8Lys.sup.26,34-bis-(GAB-GHex)-GLP-1(7-36);
Ser.sup.8Lys.sup.26,34-bis-(GAB-GHex)-GLP-1(7-37);
Ser.sup.8Lys.sup.26,34-bis-(GAB-GHex)-GLP-1(7-38);
Ser.sup.8Lys.sup.26,34-bis-(GAB-GHex)-GLP-1(7-39)
Ser.sup.8Arg.sup.26Lys.sup.34,36-bis-(GAB-GHex)-GLP-1(7-36);
Ser.sup.8Arg.sup.34Lys.sup.26,36-bis-(GAB-GHex)-GLP-1(7-36);
Ser.sup.8Arg.sup.26Lys.sup.34,36-bis-(GAB-GHex)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26,36-bis-(GAB-GHex)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34,37-bis-(GAB-GHex)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26,37-bis-(GAB-GHex)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34,38-bis-(GAB-GHex)-GLP-1(7-38);
Ser.sup.8Arg.sup.34Lys.sup.26,38-bis-(GAB-GHex)-GLP-1(7-38);
Ser.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(GAB-GHex)-GLP-1(7-38);
Ser.sup.8Arg.sup.26Lys.sup.34,39-bis-(GAB-GHex)-GLP-1(7-39);
Ser.sup.8Arg.sup.34Lys.sup.26,39-bis-(GAB-GHex)-GLP-1(7-39);
Ser.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(GAB-GHex)-GLP-1(7-39);
[1245] Thr.sup.8Lys.sup.26,34-bis-(GAB-GHex)-GLP-1(7-36);
Thr.sup.8Lys.sup.26,34-bis-(GAB-GHex)-GLP-1(7-37);
Thr.sup.8Lys.sup.26,34-bis-(GAB-GHex)-GLP-1(7-38);
Thr.sup.8Lys.sup.26,34-bis-(GAB-GHex)-GLP-1(7-39)
Thr.sup.8Arg.sup.26Lys.sup.34,36-bis-(GAB-GHex)-GLP-1(7-36);
Thr.sup.8Arg.sup.34Lys.sup.26,36-bis-(GAB-GHex)-GLP-1(7-36);
Thr.sup.8Arg.sup.26Lys.sup.34,36-bis-(GAB-GHex)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26,36-bis-(GAB-GHex)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34,37-bis-(GAB-GHex)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26,37-bis-(GAB-GHex)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34,38-bis-(GAB-GHex-GLP-1(7-38);
Thr.sup.8Arg.sup.34Lys.sup.26,38-bis-(GAB-GHex)-GLP-1(7-38);
Thr.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(GAB-GHex)-GLP-1(7-38);
Thr.sup.8Arg.sup.6Lys.sup.34,39-bis-(GAB-GHex)-GLP-1(7-39);
Thr.sup.8Arg.sup.34Lys.sup.26,39-bis-(GAB-GHex)-GLP-1(7-39);
Thr.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(GAB-GHex)-GLP-1(7-39);
[1246] Lys.sup.26,34-bis-(GAB-GOct)-GLP-1(7-36);
Lys.sup.26,34-bis-(GAB-GOct)-GLP-1(7-37);
Lys.sup.26,34-bis-(GAB-GOct)-GLP-1(7-38);
Lys.sup.26,34-bis-(GAB-GOct)-GLP-1(7-39)
Arg.sup.6Lys.sup.34,36-bis-(GAB-GOct)-GLP-1(7-36);
Arg.sup.34Lys.sup.26,36-bis-(GAB-GOct)-GLP-1(7-36);
Arg.sup.26Lys.sup.34,36-bis-(GAB-GOct)-GLP-1(7-37);
Arg.sup.34Lys.sup.26,36-bis-(GAB-GOct)-GLP-1(7-37);
Arg.sup.26Lys.sup.34,37-bis-(GAB-GOct)-GLP-1(7-37);
Arg.sup.34Lys.sup.26,37-bis-(GAB-GOct)-GLP-1(7-37);
Arg.sup.26Lys.sup.34,39-bis-(GAB-GOct)-GLP-1(7-39);
Arg.sup.34Lys.sup.26,39-bis-(GAB-GOct)-GLP-1(7-39);
Arg.sup.26,34Lys.sup.36,39-bis-(GAB-GOct)-GLP-1(7-39);
[1247] Arg.sup.26Lys.sup.18,34-bis-(GAB-GOct)-GLP-1(7-36);
Arg.sup.34Lys.sup.18,26-bis-(GAB-GOct)-GLP-1(7-36);
Arg.sup.26Lys.sup.18,34-bis-(GAB-GOct)-GLP-1(7-37);
Arg.sup.34Lys.sup.18,26-bis-(GAB-GOct)-GLP-1(7-37);
Arg.sup.26Lys.sup.18,34-bis-(GAB-GOct)-GLP-1(7-38);
Arg.sup.34Lys.sup.18,26-bis-(GAB-GOct)-GLP-1(7-38);
Arg.sup.26Lys.sup.18,34-bis-(GAB-GOct)-GLP-1(7-39);
Arg.sup.34Lys.sup.18,26-bis-(GAB-GOct)-GLP-1(7-39);
Arg.sup.26Lys.sup.23,34-bis-(GAB-GOct)-GLP-1(7-36);
Arg.sup.34Lys.sup.23,26-bis-(GAB-GOct)-GLP-1(7-36);
Arg.sup.26Lys.sup.23,34-bis-(GAB-GOct)-GLP-1(7-37);
Arg.sup.34Lys.sup.23,26-bis-(GAB-GOct)-GLP-1(7-37);
Arg.sup.26Lys.sup.23,34-bis-(GAB-GOct)-GLP-1(7-38);
Arg.sup.34Lys.sup.23,26-bis-(GAB-GOct)-GLP-1(7-38);
Arg.sup.26Lys.sup.23,34-bis-(GAB-GOct)-GLP-1(7-39);
Arg.sup.34Lys.sup.23,26-bis-(GAB-GOct)-GLP-1(7-39);
Arg.sup.26Lys.sup.27,34-bis-(GAB-GOct)-GLP-1(7-36);
Arg.sup.34Lys.sup.27,26-bis-(GAB-GOct)-GLP-1(7-36);
Arg.sup.26Lys.sup.27,34-bis-(GAB-GOct)-GLP-1(7-37);
Arg.sup.34Lys.sup.27,26-bis-(GAB-GOct)-GLP-1(7-37);
Arg.sup.26Lys.sup.27,34-bis-(GAB-GOct)-GLP-1(7-38);
Arg.sup.34Lys.sup.27,26-bis-(GAB-GOct)-GLP-1(7-38);
Arg.sup.26Lys.sup.27,34-bis-(GAB-GOct)-GLP-1(7-39);
Arg.sup.34Lys.sup.27,26-bis-(GAB-GOct)-GLP-1(7-39);
Gly.sup.8-Lys.sup.26,34-bis-(GAB-GOct)-GLP-1(7-36);
Gly.sup.8Lys.sup.26,34-bis-(GAB-GOct)-GLP-1(7-37);
Gly.sup.8Lys.sup.26,34-bis-(GAB-GOct)-GLP-1(7-38);
Gly.sup.8Lys.sup.26,34-bis-(GAB-GOct)-GLP-1(7-39)
Gly.sup.8Arg.sup.26Lys.sup.34,36-bis-(GAB-GOct)-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.26,36-bis-(GAB-GOct)-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.34,36-bis-(GAB-GOct)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26,36-bis-(GAB-GOct)-GLP-1(7-37)
Gly.sup.8Arg.sup.26Lys.sup.34,37-bis-(GAB-GOct)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26,37-bis-(GAB-GOct)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34,38-bis-(GAB-GOct)-GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.26,38-bis-(GAB-GOct)-GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(GAB-GOct)-GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.34,39-bis-(GAB-GOct)-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.26,39-bis-(GAB-GOct)-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(AB-GOct)-GLP-1(7-39);
[1248] Val.sup.8Lys.sup.26,34-bis-(GAB-GOct)-GLP-1(7-36);
Val.sup.8Lys.sup.26,34-bis-(GAB-GOct)-GLP-1(7-37);
Val.sup.8Lys.sup.26,34-bis-(GAB-GOct)-GLP-1(7-38);
Val.sup.8Lys.sup.26,34-bis-(GAB-GOct)-GLP-1(7-39);
Val.sup.8Arg.sup.26Lys.sup.34,36-bis-(GAB-GOct)-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.26,36-bis-(GAB-GOct)-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.34,36-bis-(GAB-GOct)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26,36-bis-(GAB-GOct)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34,37-bis-(GAB-GOct)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26,37-bis-(GAB-GOct)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34,38-bis-(GAB-GOct)-GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.26,38-bis-(GAB-GOct)-GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(GAB-GOct)-GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.34,39-bis-(GAB-GOct)-GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.26,39-bis-(GAB-GOct)-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(GAB-GOct)-GLP-1(7-39);
[1249] Ser.sup.8Lys.sup.26,34-bis-(GAB-GOct)-GLP-1(7-36);
Ser.sup.8Lys.sup.26,34-bis-(GAB-GOct)-GLP-1(7-37);
Ser.sup.8Lys.sup.26,34-bis-(GAB-GOct)-GLP-1(7-38);
Ser.sup.8Lys.sup.26,34-bis-(GAB-GOct)-GLP-1(7-39)
Ser.sup.8Arg.sup.26Lys.sup.34,36-bis-(GAB-GOct)-GLP-1(7-36);
Ser.sup.8Arg.sup.34Lys.sup.26,36-bis-(GAB-GOct)-GLP-1(7-36);
Ser.sup.8Arg.sup.26Lys.sup.34,36-bis-(GAB-GOct)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26,36-bis-(GAB-GOct)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34,37-bis-(GAB-GOct)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26,37-bis-(GAB-GOct)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34,38-bis-(GAB-GOct)-GLP-1(7-38);
Ser.sup.8Arg.sup.34Lys.sup.26,38-bis-(GAB-GOct)-GLP-1(7-38);
Ser.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(GAB-GOct)-GLP-1(7-38);
Ser.sup.8Arg.sup.26Lys.sup.34,39-bis-(GAB-GOct)-GLP-1(7-39);
Ser.sup.8Arg.sup.34Lys.sup.26,39-bis-(GAB-GOct)-GLP-1(7-39);
Ser.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(GAB-GOct)-GLP-1(7-39);
[1250] Thr.sup.8Lys.sup.26,34-bis-(GAB-GOct)-GLP-1(7-36);
Thr.sup.8Lys.sup.26,34-bis-(GAB-GOct)-GLP-1(7-37);
Thr.sup.8Lys.sup.26,34-bis-(GAB-GOct)-GLP-1(7-38);
Thr.sup.8Lys.sup.26,34-bis-(GAB-GOct)-GLP-1(7-39)
Thr.sup.8Arg.sup.26Lys.sup.34,36-bis-(GAB-GOct)-GLP-1(7-36);
Thr.sup.8Arg.sup.34Lys.sup.26,36-bis-(GAB-GOct)-GLP-1(7-36);
Thr.sup.8Arg.sup.26Lys.sup.34,36-bis-(GAB-GOct)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26,37-bis-(GAB-GOct)-GLP-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34,37-bis-(GAB-GOct)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26,37-bis-(GAB-GOct)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34,38-bis-(GAB-GOct)-GLP-1(7-38);
Thr.sup.8Arg.sup.34Lys.sup.26,38-bis-(GAB-GOct)-GLP-1(7-38);
Thr.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(GAB-GOct)-GLP-1(7-38);
Thr.sup.8Arg.sup.26Lys.sup.34,39-bis-(GAB-GOct)-GLP-1(7-39);
Thr.sup.8Arg.sup.34Lys.sup.26,39-bis-(GAB-GOct)-GLP-1(7-39);
Thr.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(GAB-GOct)-GLP-1(7-39);
[1251] Lys.sup.26,34-bis-(GAB-GLit)-GLP-1(7-36);
Lys.sup.26,34-bis-(GAB-GLit)-GLP-1(7-37);
Lys.sup.26,34-bis-(GAB-GLit)-GLP-1(7-38);
Lys.sup.26,34-bis-(GAB-GLit)-GLP-1(7-39)
Arg.sup.26Lys.sup.34,36-bis-(GAB-GLit)-GLP-1(7-36);
Arg.sup.34Lys.sup.26,36-bis-(GAB-GLit)-GLP-1(7-36);
Arg.sup.26Lys.sup.34,36-bis-(GAB-GLit)-GLP-1(7-37);
Arg.sup.34Lys.sup.26,36-bis-(GAB-GLit)-GLP-1(7-37);
Arg.sup.26Lys.sup.34,37-bis-(GAB-GLit)-GLP-1(7-37);
Arg.sup.34Lys.sup.26,37-bis-(GAB-GLit)-GLP-1(7-37);
Arg.sup.26Lys.sup.34,39-bis-(GAB-GLit)-GLP-1(7-39);
Arg.sup.34Lys.sup.26,39-bis-(GAB-GLit)-GLP-1(7-39);
Arg.sup.26,34Lys.sup.36,39-bis-(GAB-GLit)-GLP-1(7-39);
[1252] Arg.sup.26Lys.sup.18,34-bis-(GAB-GLit)-GLP-1(7-36);
Arg.sup.34Lys.sup.18,26-bis-(GAB-GLit)-GLP-1(7-36);
Arg.sup.26Lys.sup.18,34-bis-(GAB-GLit)-GLP-1(7-37);
Arg.sup.34Lys.sup.18,26-bis-(GAB-GLit)-GLP-1(7-37);
Arg.sup.26Lys.sup.18,34-bis-(GAB-GLit)-GLP-1(7-38);
Arg.sup.34Lys.sup.18,26-bis-(GAB-GLit)-GLP-1(7-38);
Arg.sup.26Lys.sup.18,34-bis-(GAB-GLit)-GLP-1(7-39);
Arg.sup.34Lys.sup.18,26-bis-(GAB-GLit)-GLP-1(7-39);
Arg.sup.26Lys.sup.23,34-bis-(GAB-GLit)-GLP-1(7-36);
Arg.sup.34Lys.sup.23,26-bis-(GAB-GLit)-GLP-1(7-36);
Arg.sup.26Lys.sup.23,34-bis-(GAB-GLit)-GLP-1(7-37);
Arg.sup.34Lys.sup.23,26-bis-(GAB-GLit)-GLP-1(7-37);
Arg.sup.26Lys.sup.23,34-bis-(GAB-GLit)-GLP-1(7-38);
Arg.sup.34Lys.sup.23,26-bis-(GAB-GLit)-GLP-1(7-38);
Arg.sup.26Lys.sup.23,34-bis-(GAB-GLit)-GLP-1(7-39);
Arg.sup.34Lys.sup.23,26-bis-(GAB-GLit)-GLP-1(7-39);
Arg.sup.26Lys.sup.27,34-bis-(GAB-GLit)-GLP-1(7-36);
Arg.sup.34Lys.sup.27,26-bis-(GAB-GLit)-GLP-1(7-36);
Arg.sup.26Lys.sup.27,34-bis-(GAB-GLit)-GLP-1(7-37);
Arg.sup.34Lys.sup.27,26-bis-(GAB-GLit)-GLP-1(7-37);
Arg.sup.26Lys.sup.27,34-bis-(GAB-GLit)-GLP-1(7-38);
Arg.sup.34Lys.sup.27,26-bis-(GAB-GLit)-GLP-1(7-38);
Arg.sup.26Lys.sup.27,34-bis-(GAB-GLit)-GLP-1(7-39);
Arg.sup.34Lys.sup.27,26-bis-(GAB-GLit)-GLP-1(7-39);
Gly.sup.8Lys.sup.26,34-bis-(GAB-GLit)-GLP-1(7-36);
Gly.sup.8Lys.sup.26,34-bis-(GAB-GLit)-GLP-1(7-37);
Gly.sup.8Lys.sup.26,34-bis-(GAB-GLit)-GLP-1(7-38);
Gly.sup.8Lys.sup.26,34-bis-(GAB-GLit)-GLP-1(7-39)
Gly.sup.8Arg.sup.26Lys.sup.34,36-bis-(GAB-GLit)-GLP-1(7-36);
Gly.sup.8Arg.sup.34Lys.sup.26,36-bis-(GAB-GLit)-GLP-1(7-36);
Gly.sup.8Arg.sup.26Lys.sup.34,36-bis-(GAB-GLit)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26,36-bis-(GAB-GLit)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34,37-bis-(GAB-GLit)-GLP-1(7-37);
Gly.sup.8Arg.sup.34Lys.sup.26,37-bis-(GAB-GLit)-GLP-1(7-37);
Gly.sup.8Arg.sup.26Lys.sup.34,38-bis-(GAB-GLit)-GLP-1(7-38);
Gly.sup.8Arg.sup.34Lys.sup.26,38-bis-(GAB-GLit)-GLP-1(7-38);
Gly.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(GAB-GLit)-GLP-1(7-38);
Gly.sup.8Arg.sup.26Lys.sup.34,39-bis-(GAB-GLit)-GLP-1(7-39);
Gly.sup.8Arg.sup.34Lys.sup.26,39-bis-(GAB-GLit)-GLP-1(7-39);
Gly.sup.8Arg.sup.26,34Lys.sup.36,39-bis(GAB-GLit)-GLP-1(7-39);
[1253] Val.sup.8Lys.sup.26,34-bis-(GAB-GLit)-GLP-1(7-36);
Val.sup.8Lys.sup.26,34-bis-(GAB-GLit)-GLP-1(7-37);
Val.sup.8Lys.sup.26,34-bis-(GAB-GLit)-GLP-1(7-38);
Val.sup.8Lys.sup.26,34-bis-(GAB-GLit)-GLP-1(7-39)
Val.sup.8Arg.sup.26Lys.sup.34,36-bis-(GAB-GLit)-GLP-1(7-36);
Val.sup.8Arg.sup.34Lys.sup.26,36-bis-(GAB-GLit)-GLP-1(7-36);
Val.sup.8Arg.sup.26Lys.sup.34,36-bis-(GAB-GLit)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26,36-bis-(GAB-GLit)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34,37-bis-(GAB-GLit)-GLP-1(7-37);
Val.sup.8Arg.sup.34Lys.sup.26,37-bis-(GAB-GLit)-GLP-1(7-37);
Val.sup.8Arg.sup.26Lys.sup.34,38-bis-(GAB-GLit)-GLP-1(7-38);
Val.sup.8Arg.sup.34Lys.sup.26,38-bis-(GAB-GLit)-GLP-1(7-38);
Val.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(GAB-GLit)-GLP-1(7-38);
Val.sup.8Arg.sup.26Lys.sup.34,39-bis-(GAB-GLit)-GLP-1(7-39);
Val.sup.8Arg.sup.34Lys.sup.26,39-bis-(GAB-GLit)-GLP-1(7-39);
Val.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(GAB-GLit)-GLP-1(7-39);
[1254] Ser.sup.8Lys.sup.26,34-bis-(GAB-GLit)-GLP-1(7-36);
Ser.sup.8Lys.sup.26,34-bis-(GAB-GLit)-GLP-1(7-37);
Ser.sup.8Lys.sup.26,34-bis-(GAB-GLit)-GLP-1(7-38);
Ser.sup.8Lys.sup.26,34-bis-(GAB-GLit)-GLP-1(7-39)
Ser.sup.8Arg.sup.26Lys.sup.34,36-bis-(GAB-GLit)-GLP-1(7-36);
Ser.sup.8Arg.sup.34Lys.sup.26,36-bis-(GAB-GLit)-GLP-1(7-36);
Ser.sup.8Arg.sup.26Lys.sup.34,36-bis-(GAB-GLit)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26,36-bis-(GAB-GLit)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34,37-bis-(GAB-GLit)-GLP-1(7-37);
Ser.sup.8Arg.sup.34Lys.sup.26,37-bis-(GAB-GLit)-GLP-1(7-37);
Ser.sup.8Arg.sup.26Lys.sup.34,38-bis-(GAB-GLit)-GLP-1(7-38);
Ser.sup.8Arg.sup.34Lys.sup.26,38-bis-(GAB-GLit)-GLP-1(7-38);
Ser.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(GAB-GLit)-GLP-1(7-38);
Ser.sup.8Arg.sup.26Lys.sup.34,39-bis-(GAB-GLit)-GLP-1(7-39);
Ser.sup.8Arg.sup.34Lys.sup.26,39-bis-(GAB-GLit)-GLP-1(7-39);
Ser.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(GAB-GLit)-GLP-1(7-39);
[1255] Thr.sup.8Lys.sup.26,34-bis-(GAB-GLit)-GLP-1(7-36);
Thr.sup.8Lys.sup.26,34-bis-(GAB-GLit)-GLP-1(7-37);
Thr.sup.8Lys.sup.26,34-bis-(GAB-GLit)-GLP-1(7-38);
Thr.sup.8Lys.sup.26,34-bis-(GAB-GLit)-GLP-1(7-39)
Thr.sup.8Arg.sup.26Lys.sup.34,36-bis-(GAB-GLit)-GLP-1(7-36);
Thr.sup.8Arg.sup.34Lys.sup.26,36-bis-(GAB-GLit)-GLP-1(7-36);
Thr.sup.8Arg.sup.26Lys.sup.34,36-bis-(GAB-GLit)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26,36-bis-(GAB-GLit)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34,37-bis-(GAB-GLit)-GLP-1(7-37);
Thr.sup.8Arg.sup.34Lys.sup.26,37-bis-(GAB-GLit)-GLP-1(7-37);
Thr.sup.8Arg.sup.26Lys.sup.34,38-bis-(GAB-GLit)-GLP-1(7-38);
Thr.sup.8Arg.sup.34Lys.sup.26,38-bis-(GAB-GLit)-GLP-1(7-38);
Thr.sup.8Arg.sup.26,34Lys.sup.36,38-bis-(GAB-GLit)-GLP-1(7-38);
Thr.sup.8Arg.sup.26Lys.sup.34,39-bis-(GAB-GLit)-GLP-1(7-39);
Thr.sup.8Arg.sup.34Lys.sup.26,39-bis-(GAB-GLit)-GLP-1(7-39);
Thr.sup.8Arg.sup.26,34Lys.sup.36,39-bis-(GAB-GLit)-GLP-1(7-39).
Pharmaceutical Compositions
[1256] The present invention also relates to pharmaceutical
compositions comprising a GLP-1 derivative of the present invention
and a pharmaceutically acceptable vehicle or carrier.
[1257] Preferably, the pharmaceutical compositions comprise an
isotonic agent, a preservative and a buffer. Examples of isotonic
agents are sodium chloride, mannitol and glycerol. Examples of
preservatives are phenol, m-cresol, methyl p-hydroxybenzoate and
benzyl alcohol. Suitable buffers include sodium acetate and sodium
phosphate.
[1258] The pharmaceutical compositions preferably further comprise
a surfactant in order to improve the solubility and/or the
stability of the GLP-1 derivative. Individual embodiments of the
surfactant, such as a detergent, for use in the pharmaceutical
composition of the invention include ethoxylated castor oil,
polyglycolyzed glycerides, acetylated monoglycerides, sorbitan
fatty acid esters, poloxamers, such as 188 and 407, polyoxyethylene
sorbitan fatty acid esters, polyoxyethylene derivatives such as
alkylated and alkoxylated derivatives (tweens, e.g. Tween-20),
monoglycerides or ethoxylated derivatives thereof, diglycerides or
polyoxyethylene derivatives thereof, glycerol, cholic acid or
derivatives thereof, lecithins, alcohols and phospholipids,
glycerophospholipids (lecithins, kephalins, phosphatidyl serine),
glyceroglycolipids (galactopyransoide), sphingophospholipids
(sphingomyelin), and sphingoglycolipids (ceramides, gangliosides),
DSS (docusate sodium, CAS registry no [577-11-7]), docusate
calcium, CAS registry no [128-49-4]), docusate potassium, CAS
registry no [7491-09-0]), SDS (sodium dodecyl sulfate or sodium
lauryl sulfate), dipalmitoyl phosphatidic acid, sodium caprylate,
bile acids and salts thereof and glycine or taurine conjugates,
ursodeoxycholic acid, sodium cholate, sodium deoxycholate, sodium
taurocholate, sodium glycocholate,
N-Hexadecyl-N,N-dimethyl-3-ammonio-1-propanesulfonate, anionic
(alkyl-aryl-sulphonates) monovalent surfactants, palmitoyl
lysophosphatidyl-L-serine, lysophospholipids (e.g.
1-acyl-sn-glycero-3-phosphate esters of ethanolamine, choline,
serine or threonine), alkyl, alkoxyl (alkyl ester), alkoxy (alkyl
ether)-derivatives of lysophosphatidyl and phosphatidylcholines,
e.g. lauroyl and myristoyl derivatives of lysophosphatidylcholine,
dipalmitoylphosphatidylcholine, and modifications of the polar head
group, that is cholines, ethanolamines, phosphatidic acid, serines,
threonines, glycerol, inositol, and the postively charged DODAC,
DOTMA, DCP, BISHOP, lysophosphatidylserine and
lysophosphatidylthreonine, zwitterionic surfactants (e.g.
N-alkyl-N,N-dimethylammonio-1-propanesulfonates,
3-cholamido-1-propyldimethylammonio-1-propanesulfonate,
dodecylphosphocholine, myristoyl lysophosphatidylcholine, hen egg
lysolecithin), cationic surfactants (quarternary ammonium bases)
(e.g. cetyl-trimethylammonium bromide, cetylpyridinium chloride),
non-ionic surfactants, polyethyleneoxide/polypropyleneoxide block
copolymers (Pluronics/Tetronics, Triton X-100, Dodecyl
.beta.-D-glucopyranoside) or polymeric surfactants (Tween-40,
Tween-80, Brij-35). Other preferred surfactants include fusidic
acid derivatives-(e.g. sodium tauro-dihydrofusidate etc.),
long-chain fatty acids and salts thereof C6-C12 (eg. oleic acid and
caprylic acid), acylcarnitines and derivatives,
N.sup..alpha.-acylated derivatives of lysine, arginine or
histidine, or side-chain acylated derivatives of lysine or
arginine, N.sup..alpha.-acylated derivatives of dipeptides
comprising any combination of lysine, arginine or histidine and a
neutral or acidic amino acid, N.sup..alpha.-acylated derivative of
a tripeptide comprising any combination of a neutral amino acid and
two charged amino acids, or the surfactant may be selected from the
group of imidazoline derivatives.
[1259] One group of preferred surfactants consists of zwitterionic
surfactants, cationic surfactants, non-ionic surfactants and
polymeric surfactants. Another group of preferred surfactants
consists of SDS, sodium caprylate, sodium cholate, sodium
deoxycholate, sodium taurocholate and sodium glycocholate.
[1260] A further group of preferred surfactants consists of lauroyl
lysophosphatidylcholine, palmitoyl lysophosphatidyl-L-serine,
myristoyl lysophosphatidylcholine and
N-Hexadecyl-N,N-dimethyl-3-ammonio-1-propanesulfonate.
[1261] The pharmaceutical compositions preferably also comprise
zinc.
[1262] The pharmaceutial compositions preferably further comprise
another antidiabetic agent. The term "antidiabetic agent" includes
compounds for the treatment and/or prophylaxis of insulin
resistance and diseases wherein insulin resistance is the
pathophysiological mechanism.
[1263] In one embodiment of this invention, the antidiabetic agent
is an insulin, more preferably human insulin.
[1264] In another embodiment the antidiabetic agent is a
hypoglycaemic agent, preferably an oral hypoglycaemic agent. Oral
hypoglycaemic agents are preferably selected from the group
consisting of sulfonylureas, biguanides, thiazolidinediones,
glucosidase inhibitors, glucagon antagonists, GLP-1 agonists,
potasium channel openers, insulin sensitizers, hepatic enzyme
inhibitors, glucose uptake modulators, compounds modifying the
lipid metabolism, compounds lowering food intake, and agents acting
on the ATP-dependent potassium channel of the .beta.-cells.
Preferred sulfonylureas are tolbutamide, glibenclamide, glipizide
and gliclazide. A preferred biguanide is metformin. Preferred
thiazolidinediones are troglitazone and ciglitazone. A preferred
glucosidase inhibitors is acarbose. Preferred agents acting on the
ATP-dependent potassium channel of the .beta.-cells are:
glibenclamide, glipizide, gliclazide, and repaglinide.
[1265] The pharmaceutical compositions of the present invention may
further comprise another antiobesity agent.
[1266] In one embodiment of this invention, the antiobesity agent
is leptin.
[1267] In another embodiment the antiobesity agent is
amphetamin.
[1268] In another embodiment the antiobesity agent is
dexfenfluramine.
[1269] In another embodiment the antiobesity agent is
sibutramine.
[1270] In another embodiment the antiobesity agent is orlistat.
[1271] In another embodiment the antiobesity agent is selected from
a group of CART agonists, NPY antagonists, orexin antagonists,
H3-antagonists, TNF agonists, CRF agonists, CRF BP antagonists,
urocortin agonists, ?3 agonists, MSH agonists, CCK agonists,
serotonin re-uptake inhibitors, mixed serotonin and noradrenergic
compounds, 5HT agonists, bombesin agonists, galanin antagonists,
growth hormone, growth hormone releasing compounds, glucagon, TRH
agonists, uncoupling protein 2 or 3 modulators, leptin agonists, DA
agonists (Bromocriptin, Doprexin), lipase/amylase inhibitors, PPAR
modulators, PXR modulators or TR ? agonists.
[1272] The present invention also relates to pharmaceutical
compositions comprising water and a GLP-1 derivative which has a
helix content as measured by CD at 222 nm in H.sub.2O at 22.+-.2?C
exceeding 25%, preferably in the range of 25% to 50%, at a peptide
concentration of about 10 ?M. The size of the partially helical,
micelle-like aggregates may be estimated by size-exclusion
chromatography. Similarly, the apparent (critical micelle
concentrations) CMC's of the peptides may be estimated from the
concentration dependent fluorescence in the presence of appropriate
dyes (e.g. Brito, R. & Vaz, W. (1986) Anal. Biochem. 152,
250-255).
[1273] That the derivatives have a partially structured
micellar-like aggregate conformation in aqueous solutions makes
them more soluble and stable in solution as compared to the native
peptide. The increased solubility and stability can be seen by
comparing the solubility after 9 days of standing for a derivative
and native GLP-1(7-37) in a pharmaceutical formulation, e.g. 5 mM
phosphate buffer, pH 6.9 added 0.1 M NaCl.
[1274] Circular Dichroism (CD) can be used to show that the GLP-1
derivatives have a certain partially structured conformation
independent of their concentration. In contrast, for native
GLP-1(7-37) an increase in the helix content is seen with
increasing concentration, from 10-15% to 30-35% (at 500 ?M
concentration) in parallel with peptide self-association. For the
GLP-1 derivatives forming partially structured micellar-like
aggregates in aqueous solution the helix content remains constant
above 30% at concentrations of 10 ?M. The aggregated structured
conformation is an inherent property of the derivative present in
water or dilute aqueous buffer without the need for any additional
structure-inducing components.
[1275] The pharmaceutical compositions of the present invention may
be prepared by conventional techniques, e.g. as described in
Remington's Pharmaceutical Sciences, 1985 or in Remington: The
Science and Practice of Pharmacy, 19.sup.th edition, 1995.
[1276] For example, injectable compositions of the GLP-1 derivative
of the invention can be prepared using the conventional techniques
of the pharmaceutical industry which involves dissolving and mixing
the ingredients as appropriate to give the desired end product.
[1277] A composition for nasal administration of certain peptides
may, for example, be prepared as described in European Patent No.
272097 (to Novo Nordisk A/S) or in WO 93/18785.
[1278] In a preferred embodiment of the present invention, the
GLP-1 derivative is provided in the form of a composition suitable
for administration by injection. Such a composition can either be
an injectable solution ready for use or it can be an amount of a
solid composition, e.g. a lyophilised product, which has to be
dissolved in a solvent before it can be injected. The injectable
solution preferably contains not less than about 2 mg/ml,
preferably not less than about 5 mg/ml, more preferred not less
than about 10 mg/ml of the GLP-1 derivative and, preferably, not
more than about 100 mg/ml of the GLP-1 derivative.
Uses
[1279] The present invention also relates to the use of a GLP-1
derivative of the invention for the preparation of a medicament
which has a protracted profile of action relative to
GLP-1(7-37).
[1280] The present invention relates also to the use of a GLP-1
derivative of the invention for the preparation of a medicament
with protracted effect for the treatment of non-insulin dependent
diabetes mellitus.
[1281] The present invention also relates to the use of a GLP-1
derivative of the invention for the preparation of a medicament
with protracted effect for the treatment of insulin dependent
diabetes mellitus.
[1282] The present invention also relates to the use of a GLP-1
derivative of the invention for the preparation of a medicament
with protracted effect for the treatment of obesity.
[1283] The present invention also relates to the use of a GLP-1
derivative of the present invention for treating insulin
resistance.
[1284] The present invention also relates to the use of a GLP-1
derivative of the present invention for the preparation of a
medicament with protracted effect for the treatment of obesity.
[1285] The present invention relates to a method of treating
insulin dependent or non-insulin dependent diabetes mellitus in a
patient in need of such a treatment, comprising administering to
the patient a therapeutically effective amount of a GLP-1
derivative of the present invention together with a
pharmaceutically acceptable carrier.
[1286] The present invention relates to a method of treating
obesity in a patient in need of such a treatment, comprising
administering to the patient a therapeutically effective amount of
a GLP-1 derivative of the present invention together with a
pharmaceutically acceptable carrier.
[1287] The particular GLP-1 derivative to be used and the optimal
dose level for any patient will depend on the disease to be treated
and on a variety of factors including the efficacy of the specific
peptide derivative employed, the age, body weight, physical
activity, and diet of the patient, on a possible combination with
other drugs, and on the severity of the case.
[1288] The pharmaceutical compositions of the present invention may
be administered parenterally to patients in need of such a
treatment. Parenteral administration may be performed by
subcutaneous, intramuscular or intravenous injection by means of a
syringe, optionally a pen-like syringe. Alternatively, parenteral
administration can be performed by means of an infusion pump. A
further option is a composition which may be a powder or a liquid
for the administration of the GLP-1 derivative in the form of a
nasal or pulmonal spray. As a still further option, the GLP-1
derivatives of the invention can also be administered
transdermally, e.g. from a patch, optionally a iontophoretic patch,
or transmucosally, e.g. bucally.
Methods of Production
[1289] The parent peptide can be produced by a method which
comprises culturing a host cell containing a DNA sequence encoding
the polypeptide and capable of expressing the polypeptide in a
suitable nutrient medium under conditions permitting the expression
of the peptide, after which the resulting peptide is recovered from
the culture.
[1290] The medium used to culture the cells may be any conventional
medium suitable for growing the host cells, such as minimal or
complex media containing appropriate supplements. Suitable media
are available from commercial suppliers or may be prepared of
published recipes (e.g. in catalogues of the American Type Culture
Collection). The peptide produced by the cells may then be
recovered from the culture medium by conventional procedures
including separating the host cells from the medium by
centrifugation or filtration, precipitating the proteinaceous
components of the supernatant or filtrate by means of a salt, e.g.
ammonium sulphate, purification by a variety of chromatographic
procedures, e.g. ion exchange chromatography, gel filtration
chromatography, affinity chromatography, or the like, dependent on
the type of peptide in question.
[1291] The DNA sequence encoding the parent peptide may suitably be
of genomic or cDNA origin, for instance obtained by preparing a
genomic or cDNA library and screening for DNA sequences coding for
all or part of the peptide by hybridisation using synthetic
oligonucleotide probes in accordance with standard techniques (see,
for example, Sambrook, J, Fritsch, E F and Maniatis, T, Molecular
Cloning: A Laboratory Manual, Cold Spring Harbor Laboratory Press,
New York, 1989). The DNA sequence encoding the peptide may also be
prepared synthetically by established standard methods, e.g. the
phosphoamidite method described by Beaucage and Caruthers,
Tetrahedron Letters 22 (1981), 1859-1869, or the method described
by Matthes et al., EMBO Journal 3 (1984), 801-805. The DNA sequence
may also be prepared by polymerase chain reaction using specific
primers, for instance as described in U.S. Pat. No. 4,683,202 or
Saiki et al., Science 239 (1988), 487-491.
[1292] The DNA sequence may be inserted into any vector which may
conveniently be subjected to recombinant DNA procedures, and the
choice of vector will often depend on the host cell into which it
is to be introduced. Thus, the vector may be an autonomously
replicating vector, i.e. a vector which exists as an
extrachromosomal entity, the replication of which is independent of
chromosomal replication, e.g. a plasmid. Alternatively, the vector
may be one which, when introduced into a host cell, is integrated
into the host cell genome and replicated together with the
chromosome(s) into which it has been integrated.
[1293] The vector is preferably an expression vector in which the
DNA sequence encoding the peptide is operably linked to additional
segments required for transcription of the DNA, such as a promoter.
The promoter may be any DNA sequence which shows transcriptional
activity in the host cell of choice and may be derived from genes
encoding proteins either homologous or heterologous to the host
cell. Examples of suitable promoters for directing the
transcription of the DNA encoding the peptide of the invention in a
variety of host cells are well known in the art, cf. for instance
Sambrook et al., supra.
[1294] The DNA sequence encoding the peptide may also, if
necessary, be operably connected to a suitable terminator,
polyadenylation signals, transcriptional enhancer sequences, and
translational enhancer sequences. The recombinant vector of the
invention may further comprise a DNA sequence enabling the vector
to replicate in the host cell in question.
[1295] The vector may also comprise a selectable marker, e.g. a
gene the product of which complements a defect in the host cell or
one which confers resistance to a drug, e.g. ampicillin, kanamycin,
tetracyclin, chloramphenicol, neomycin, hygromycin or
methotrexate.
[1296] To direct a parent peptide of the present invention into the
secretory pathway of the host cells, a secretory signal sequence
(also known as a leader sequence, prepro sequence or pre sequence)
may be provided in the recombinant vector. The secretory signal
sequence is joined to the DNA sequence encoding the peptide in the
correct reading frame. Secretory signal sequences are commonly
positioned 5' to the DNA sequence encoding the peptide. The
secretory signal sequence may be that normally associated with the
peptide or may be from a gene encoding another secreted
protein.
[1297] The procedures used to ligate the DNA sequences coding for
the present peptide, the promoter and optionally the terminator
and/or secretory signal sequence, respectively, and to insert them
into suitable vectors containing the information necessary for
replication, are well known to persons skilled in the art (cf., for
instance, Sambrook et al., supra).
[1298] The host cell into which the DNA sequence or the recombinant
vector is introduced may be any cell which is capable of producing
the present peptide and includes bacteria, yeast, fungi and higher
eukaryotic cells. Examples of suitable host cells well known and
used in the art are, without limitation, E. coli, Saccharomyces
cerevisiae, or mammalian BHK or CHO cell lines.
[1299] The GLP-1 derivatives of this invention can be used in the
treatment of various diseases. The particular GLP-1 derivative to
be used and the optimal dose level for any patient will depend on
the disease to be treated and on a variety of factors including the
efficacy of the specific peptide derivative employed, the age, body
weight, physical activity, and diet of the patient, on a possible
combination with other drugs, and on the severity of the case. It
is recommended that the dosage of the GLP-1 derivative of this
invention be determined for each individual patient by those
skilled in the art.
[1300] In particular, it is envisaged that the GLP-1 derivative
will be useful for the preparation of a medicament with a
protracted profile of action for the treatment of non-insulin
dependent diabetes mellitus and/or for the treatment of
obesity.
[1301] The present invention is further illustrated by the
following examples which, however, are not to be construed as
limiting the scope of protection. The features disclosed in the
foregoing description and in the following examples may, both
separately and in any combination thereof, be material for
realising the invention in diverse forms thereof
EXAMPLES
[1302] The following acronyms for commercially available chemicals
are used:
DMF: N,N-Dimethylformamide
DCC: N,N-Dicyclohexylcarbodiimide
NMP: N-Methyl-2-pyrrolidone
EDPA: N-Ethyl-N,N-diisopropylamine
EGTA: Ethylene glycol-bis(?-aminoethyl ether)-N,N,N',N'-tetraacetic
acid
GTP: Guanosine 5'-triphosphate
TFA: Trifluoroacetic acid
THF: Tetrahydrofuran
H-Glu(OH)--OBu.sup.t: L-Glutamic acid ?-tert-butyl ester
Cac-ONSu: Decanoic acid 2,5-dioxopyrrolidin-1-yl ester
Cap-ONSu: Octanoic acid 2,5-dioxopyrrolidin-1-yl ester
Lau-ONSu: Dodecanoic acid 2,5-dioxopyrrolidin-1-yl ester
Myr-ONSu: Tetradecanoic acid 2,5-dioxopyrrolidin-1-yl ester
Pal-ONSu: Hexadecanoic acid 2,5-dioxopyrrolidin-1-yl ester
Ste-ONSu Octadecanoic acid 2,5-dioxopyrrolidin-1-yl ester
Abbreviations:
PDMS: Plasma Desorption Mass Spectrometry
MALDI-MS: Matrix Assisted Laser Desorption/Ionisation Mass
Spectrometry
HPLC: High Performance Liquid Chromatography amu: atomic mass
units
Lit-Glu(ONSu)-OBu.sup.8: N.sup.?-Lithochoyl-L-glutamic acid
?-t-butyl ester ?-2,5-dioxopyrrolidin-1-yl ester
Cap-Glu(ONSu)-OBu.sup.t: N.sup.?-Octanoyl-L-glutamic acid ?-t-butyl
ester ?-2,5-dioxopyrrolidin-1-yl ester
Cac-Glu(ONSu)-OBu.sup.t: N.sup.?-Decanoyl-L-glutamic acid ?-t-butyl
ester ?-2,5-dioxopyrrolidin-1-yl ester
Lau-Glu(ONSu)-OBu.sup.t: N.sup.?-Dodecanoyl-L-glutamic acid
?-t-butyl ester ?-2,5-dioxopyrrolidin-1-yl ester
Myr-Glu(ONSu)-OBu.sup.t: N.sup.?-Tetradecanoyl-L-glutamic acid
?-t-butyl ester ?-2,5-dioxopyrrolidin-1-yl ester
Pal-Glu(ONSu)-OBu.sup.t: N.sup.?-Hexadecanoyl-(L)-glutamic acid
?-t-butyl-?-2,5-dioxopyrrolidin-1-yl diester
Ste-Glu(ONSu)-OBu.sup.t: N.sup.?-Octadecanoyl-(L)-glutamic acid
?-t-butyl-?-2,5-dioxopyrrolidin-1-yl diester
Lau-?-Ala-ONSu: N.sup.?-Dodecanoyl-?-alanine
2,5-dioxopyrrolidin-1-yl ester
Pal-?-Ala-ONSu: N.sup.?-Hexadecanoyl-?-alanine
2,5-dioxopyrrolidin-1-yl ester
Lau-GABA-ONSu: N.sup.?-Dodecanoyl-?-aminobutyric acid
2,5-dioxopyrrolidin-1-yl ester
Myr-GABA-ONSu: N.sup.?-Tetradecanoyl-?-aminobutyric acid
2,5-dioxopyrrolidin-1-yl ester
Pal-GABA-ONSu: N.sup.?-Hexadecanoyl-?-aminobutyric acid
2,5-dioxopyrrolidin-1-yl ester
Ste-GABA-ONSu: N.sup.?-Octadecanoyl-?-aminobutyric acid
2,5-dioxopyrrolidin-1-yl ester
Pal-Isonip-ONSu: N-Hexadecanoyl-piperidine-4-carboxylic acid
2,5-dioxopyrrolidin-1-yl ester
Pal-Glu(OBu.sup.t)-ONSu: N.sup.?-Hexadecanoyl-L-glutaric acid
?-2,5-dioxopyrrolidin-1-yl ester?-t-butyl ester
HOOC--(CH.sub.2).sub.6--COONSu: ?-Carboxyheptanoic acid
2,5-dioxopyrrolidin-1-yl ester
HOOC--(CH.sub.2).sub.10--COONSu: ?-Carboxyundecanoic acid
2,5-dioxopyrrolidin-1-yl ester
HOOC--(CH.sub.2).sub.12--COONSu: ?-Carboxytridecanoic acid
2,5-dioxopyrrolidin-1-yl ester
HOOC--(CH.sub.2).sub.14--COONSu: ?-Carboxypentadecanoic acid
2,5-dioxopyrrolidin-1-yl ester
HOOC--(CH.sub.2).sub.16--COONSu: ?-Carboxyheptadecanoic acid
2,5-dioxopyrrolidin-1-yl ester
HOOC--(CH.sub.2).sub.18-COONSu: ?-Carboxynonadecanoic acid
2,5-dioxopyrrolidin-1-yl ester
N.sup.?-alkanoyl-Glu(ONSu)-OBu.sup.t: N.sup.?-Alkanoyl-(L)-glutamic
acid ?-t-butyl-?-2,5-dioxopyrrolidin-1-yl diester
Analytical
Plasma Desorption Mass Spectrometry
Sample Preparation:
[1303] The sample is dissolved in 0.1% TFA/EtOH (1:1) at a
concentration of 1 .mu.g/.mu.l. The sample solution (5-10 .mu.l) is
placed on a nitrocellulose target (Bio-ion AB, Uppsala, Sweden) and
allowed to adsorb to the target surface for 2 minutes. The target
is subsequently rinsed with 2.times.25 .mu.l 0.1% TFA and
spin-dried. Finally, the nitrocellulose target is placed in a
target carrousel and introduced into the mass spectrometer.
MS Analysis:
[1304] PDMS analysis was carried out using a Bio-ion 20 time-of
flight instrument (Bio-ion Nordic AB, Uppsala, Sweden). An
acceleration voltage of 15 kV was applied and molecular ions formed
by bombardment of the nitrocellulose surface with 252-Cf fission
fragments were accelerated towards a stop detector. The resulting
time-of-flight spectrum was calibrated into a true mass spectrum
using the H.sup.+ and NO.sup.+ ions at m/z 1 and 30, respectively.
Mass spectra were generally accumulated for 1.0.times.10.sup.6
fission events corresponding to 15-20 minutes. Resulting assigned
masses all correspond to isotopically averaged molecular masses.
The accuracy of mass assignment is generally better than 0.1%.
MALDI-MS
[1305] MALDI-TOF MS analysis was carried out using a Voyager RP
instrument (PerSeptive Biosystems Inc., Framingham, Mass.) equipped
with delayed extraction and operated in linear mode.
Alpha-cyano-4-hydroxy-cinnamic acid was used as matrix, and mass
assignments were based on external calibration.
Example 1
Synthesis of Lys.sup.26(N.sup.?-tetradecanoyl)-GLP-1(7-37)
[1306] The title compound was synthesised from GLP-1(7-37). A
mixture of GLP-1(7-37) (25 mg, 7.45 .mu.m), EDPA (26.7 mg, 208
.mu.m), NMP (520 ?l) and water (260 ?l) was gently shaken for 5
min. at room temperature. To the resulting mixture was added a
solution of Myr-ONSu (2.5 mg, 7.67 .mu.m) in NMP (62.5 ?l), the
reaction mixture was gently shaken for 5 min. at room temperature
and then allowed to stand for 20 min. An additional amount of
Myr-ONSu (2.5 mg, 7.67 .mu.m) in NMP (62.5 ?l) was added and the
resulting mixture gently shaken for 5 min. After a total reaction
time of 40 min. the reaction was quenched by the addition of a
solution of glycine (12.5 mg, 166 .mu.mol) in 50% aqueous ethanol
(12.5 ml). The title compound was isolated from the reaction
mixture by HPLC using a cyanopropyl column (Zorbax 300SB-CN) and a
standard acetonitrile/TFA system, yield: 1.3 mg (corresponding to
4.9% of the theoretical yield). The column was heated to 65?C and
the acetonitrile gradient was 0-100% in 60 minutes. The isolated
product was analysed by PDMS and the m/z value for the protonated
molecular ion was found to be 3567.9.+-.3. The resulting molecular
weight was thus 3566.9.+-.3 amu (theoretical value: 3565.9 amu).
The position of acylation (Lys26) was verified by enzymatic
cleavage of the title compound with Staphylococcus aureus V8
protease and subsequent mass determination of the peptide fragments
by PDMS.
[1307] In addition to the title compound two other GLP-1
derivatives were isolated from the reaction mixture by using the
same chromatographic column and a more shallow gradient (35-38%
acetonitrile in 60 minutes), see Examples 2 and 3.
Example 2
Synthesis of Lys.sup.34(N.sup.?-tetradecanoyl)-GLP-1(7-37)
[1308] The title compound was isolated by HPLC from the reaction
mixture described in Example 1. PDMS analysis yielded a protonated
molecular ion at m/z 3567.7.+-.3. The molecular weight was found to
be 3566.7.+-.3 amu (theoretical value: 3565.9 amu). The acylation
site was determined on the basis of the fragmentation pattern.
Example 3
Synthesis of
Lys.sup.26,34-bis(N.sup.?-tetradecanoyl)-GLP-1(7-37)
[1309] The title compound was isolated by HPLC from the reaction
mixture described in Example 1. PDMS analysis yielded a protonated
molecular ion at m/z 3778.4.+-.3. The molecular weight was found to
be 3777.4.+-.3 amu (theoretical value: 3776.1 amu).
Example 4
Synthesis of
Lys.sup.26(N.sup.?-tetradecanoyl)Arg.sup.34-GLP-1(7-37)
[1310] The title compound was synthesised from
Arg.sup.34-GLP-1(7-37). A mixture of Arg.sup.34-GLP-1(7-37) (5 mg,
1.47 .mu.m), EDPA (5.3 mg, 41.1 .mu.m), NMP (105 ?l) and water (50
?l) was gently shaken for 5 min. at room temperature. To the
resulting mixture was added a solution of Myr-ONSu (0.71 mg, 2.2
.mu.m) in NMP (17.8 ?l), the reaction mixture was gently shaken for
5 min. at room temperature and then allowed to stand for 20 min.
After a total reaction time of 30 min. the reaction was quenched by
the addition of a solution of glycine (25 mg, 33.3 gum) in 50%
aqueous ethanol (2.5 ml). The reaction mixture was purified by HPLC
as described in Example 1. PDMS analysis yielded a protonated
molecular ion at m/z 3594.9.+-.3. The molecular weight was found to
be 3593.9.+-.3 amu (theoretical value: 3593.9 amu).
Example 5
Synthesis of
Gly.sup.8Arg.sup.26,34Lys.sup.36(N.sup.?-tetradecanoyl)-GLP-1(7-37)
[1311] The title compound was synthesised from
Gly.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(7-37) which was purchased
from QCB. A mixture of Gly.sup.8Arg.sup.26,34Lys.sup.36-GLP-1(7-37)
(1.3 mg, 0.39 .mu.m), EDPA (1.3 mg, 10 .mu.m), NMP (125 ?l) and
water (30 ?l) was gently shaken for 5 min. at room temperature. To
the resulting mixture was added a solution of Myr-ONSu (0.14 mg,
0.44 .mu.m) in NMP (3.6 ml), the reaction mixture was gently shaken
for 15 min. at room temperature. The reaction was quenched by the
addition of a solution of glycine (0.1 mg, 1.33 .mu.m) in 50%
aqueous ethanol (10 ?l). The reaction mixture was purified by HPLC,
and the title compound (60 ?g, 4%) was isolated.
Example 6
Synthesis of Arg.sup.26,34Lys.sup.36
(N.sup.?-tetradecanoyl)-GLP-1(7-37)--OH
[1312] A mixture of Arg.sup.26,34Lys.sup.36-GLP-1(7-37)--OH (5.0
mg, 1.477 .mu.mol), EDPA (5.4 mg, 41.78 .mu.mol), NMP (105 .mu.l)
and water (50 .mu.l) was gently shaken for 5 min. at room
temperature. To the resulting mixture was added a solution of
Myr-ONSu (0.721 mg, 2.215 .mu.mol) in NMP (18 .mu.l). The reaction
mixture was gently shaken for 5 min. at room temperature, and then
allowed to stand for an additional 45 min. at room temperature. The
reaction was quenched by the addition of a solution of glycine (2.5
mg, 33.3 .mu.mol) in 50% aqueous ethanol (250 .mu.l). The reaction
mixture was purified by column chromatography using a cyanopropyl
column (Zorbax 300SB-CN) and a standard acetonitrile/TFA system.
The column was heated to 65?C and the acetonitrile gradient was
0-100% in 60 minutes. The title compound (1.49 mg, 28%) was
isolated, and the product was analysed by PDMS. The m/z value for
the protonated molecular ion was found to be 3595.+-.3. The
resulting molecular weight was thus 3594.+-.3 amu (theoretical
value 3594 amu).
Example 7
Synthesis of
Lys.sup.26,34-bis(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-37)--OH
[1313] A mixture of GLP-1(7-37)--OH (70 mg, 20.85 .mu.mol), EDPA
(75.71 mg, 585.8 .mu.mol), NMP (1.47 ml) and water (700 .mu.L) was
gently shaken for 10 min. at room temperature. To the resulting
mixture was added a solution of HOOC--(CH.sub.2).sub.18--COONSu
(27.44 mg, 62.42 .mu.mol) in NMP (686 .mu.l), the reaction mixture
was gently shaken for 5 min. at room temperature, and then allowed
to stand for an additional 50 min. at room temperature. The
reaction was quenched by the addition of a solution of glycine
(34.43 mg, 458.7 .mu.mol) in 50% aqueous ethanol (3.44 ml). The
reaction mixture was purified by column chromatography using a
cyanopropyl column (Zorbax 300SB-CN) and a standard
acetonitrile/TFA system. The column was heated to 65?C and the
acetonitrile gradient was 0-100% in 60 minutes. The title compound
(8.6 mg, 10%) was isolated, and the product was analysed by PDMS.
The m/z value for the protonated molecular ion was found to be
4006.+-.3. The resulting molecular weight was thus 4005.+-.3 amu
(theoretical value 4005 amu).
Example 8
Synthesis of
Arg.sup.26,34Lys.sup.36(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-36)--OH
[1314] A mixture of Arg.sup.26,34Lys.sup.36-GLP-1(7-36)--OH (5.06
mg, 1.52 .mu.mol), EDPA (5.5 mg, 42.58 .mu.mol), NMP (106 .mu.l)
and water (100 .mu.l) was gently shaken for 5 min. at room
temperature. To the resulting mixture was added a solution of
HOOC--(CH.sub.2).sub.18-COONSu (1.33 mg, 3.04 .mu.mol) in NMP (33.2
.mu.l), the reaction mixture was gently shaken for 5 min. at room
temperature, and then allowed to stand for an additional 2.5 h at
room temperature. The reaction was quenched by the addition of a
solution of glycine (2.50 mg, 33.34 .mu.mol) in 50% aqueous ethanol
(250 .mu.l). The reaction mixture was purified by column
chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a
standard acetonitrile/TFA system. The column was heated to
65.degree. C. and the acetonitrile gradient was 0-100% in 60
minutes. The title compound (0.46 mg, 8%) was isolated, and the
product was analysed by PDMS. The m/z value for the protonated
molecular ion was found to be 3652.+-.3. The resulting molecular
weight was thus 3651.+-.3 amu (theoretical value 3651 amu).
Example 9
Synthesis of
Arg.sup.26,34Lys3(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-38)--OH
[1315] A mixture of Arg.sup.26,34Lys.sup.38-GLP-1(7-38)--OH (5.556
mg, 1.57 .mu.mol), EDPA (5.68 mg, 43.96 .mu.mol), NMP (116.6 .mu.l)
and water (50 .mu.l) was gently shaken for 10 min. at room
temperature. To the resulting mixture was added a solution
HOOC--(CH.sub.2).sub.18--COONSu (1.38 mg, 3.14 .mu.mol) in NMP
(34.5 .mu.l), the reaction mixture was gently shaken for 5 min. at
room temperature, and then allowed to stand for an additional 2.5 h
at room temperature. The reaction was quenched by the addition of a
solution of glycine (2.5 mg, 33.3 .mu.mol) in 50% aqueous ethanol
(250 .mu.l). The reaction mixture was purified by column
chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a
standard acetonitrile/TFA system. The column was heated to 65?C and
the acetonitrile gradient was 0-100% in 60 minutes. The title
compound (0.7 mg, 12%) was isolated, and the product was analysed
by PDMS. The m/z value for the protonated molecular ion was found
to be 3866.+-.3. The resulting molecular weight was thus 3865.+-.3
amu (theoretical value 3865 amu).
Example 10
Synthesis of
Arg.sup.34Lys.sup.26(N.sup.?-(?-carboxynonadecanoyl))-GLP-1(7-37)--OH
[1316] A mixture of Arg.sup.34-GLP-1(7-37)--OH (5.04 mg, 1.489
.mu.mol), EDPA (5.39 mg, 41.70 .mu.mol), NMP (105 .mu.l) and water
(50 .mu.l) was gently shaken for 10 min. at room temperature. To
the resulting mixture was added a solution
HOOC--(CH.sub.2).sub.18--COONSu (1.31 mg, 2.97 .mu.mol) in NMP
(32.8 .mu.l), the reaction mixture was gently shaken for 5 min. at
room temperature, and then allowed to stand for an additional 30
min. at room temperature. The reaction was quenched by the addition
of a solution of glycine (2.46 mg, 32.75 .mu.mol) in 50% aqueous
ethanol (246 .mu.l). The reaction mixture was purified by column
chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a
standard acetonitrile/TFA system. The column was heated to 65?C and
the acetonitrile gradient was 0-100% in 60 minutes. The title
compound (1.2 mg, 22%) was isolated, and the product was analysed
by PDMS. The m/z value for the protonated molecular ion was found
to be 3709.+-.3. The resulting molecular weight was thus 3708.+-.3
amu (theoretical value 3708 amu).
Example 11
Synthesis of Arg.sup.34Lys.sup.26
(N.sup.48-(?-carboxyheptadecanoyl))-GLP-1(7-37)--OH
[1317] A mixture of Arg.sup.34-GLP-1(7-37)--OH (5.8 mg, 1.714
.mu.mol), EDPA (6.20 mg, 47.99 .mu.mol), NMP (121.8 .mu.l) and
water (58 .mu.l) was gently shaken for 10 min. at room temperature.
To the resulting mixture was added a solution
HOOC--(CH.sub.2).sub.16--COONSu (2.11 mg, 5.142 .mu.mol) in NMP
(52.8 .mu.l), the reaction mixture was gently shaken for 5 min. at
room temperature, and then allowed to stand for an additional 2 h
at room temperature. The reaction was quenched by the addition of a
solution of glycine (2.83 mg, 37.70 .mu.mol) in 50% aqueous ethanol
(283 .mu.l). The reaction mixture was purified by column
chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a
standard acetonitrile/TFA system. The column was heated to 65?C and
the acetonitrile gradient was 0-100% in 60 minutes. The title
compound (0.81 mg, 13%) was isolated, and the product was is
analysed by PDMS. The m/z value for the protonated molecular ion
was found to be 3681.+-.3. The resulting molecular weight was thus
3680.+-.3 amu (theoretical value 3680 amu).
Example 12
Synthesis of Arg.sup.26,34Lys.sup.36
(N.sup.48-(?-carboxyheptadecanoyl))-GLP-1(7-37)--OH
[1318] A mixture of Arg.sup.26,34Lys.sup.36-GLP-1(7-37)--OH (3.51
mg, 1.036 .mu.mol), EDPA (3.75 mg, 29.03 .mu.mol), NMP (73.8 .mu.l)
and water (35 .mu.l) was gently shaken for 10 min. at room
temperature. To the resulting mixture was added a solution
HOOC--(CH.sub.2).sub.16--COONSu (1.27 mg, 3.10 .mu.mol) in NMP
(31.8 .mu.l), the reaction mixture was gently shaken for 5 min. at
room temperature, and then allowed to stand for an additional 2 h
and 10 min. at room temperature. The reaction was quenched by the
addition of a solution of glycine (1.71 mg, 22.79 .mu.mol) in 50%
aqueous ethanol (171 .mu.l). The reaction mixture was purified by
column chromatography using a cyanopropyl column (Zorbax 300SB-CN)
and a standard acetonitrile/TFA system. The column was heated to
65?C and the acetonitrile gradient was 0-100% in 60 minutes. The
title compound (0.8 mg, 21%) was isolated, and the product was
analysed by PDMS. The m/z value for the protonated molecular ion
was found to be 3682.+-.3. The resulting molecular weight was thus
3681.+-.3 amu (theoretical value 3681 amu).
Example 13
Synthesis of
Arg.sup.26,34Lys38(N.sup.?-(?-carboxyheptadecanoyl))-GLP-1(7-38)--OH
[1319] A mixture of Arg.sup.26,34Lys.sup.38-GLP-1(7-38)--OH (5.168
mg, 1.459 .mu.mol), EDPA (5.28 mg, 40.85 .mu.mol), NMP (108.6
.mu.l) and water (51.8 .mu.l) was gently shaken for 10 min. at room
temperature. To the resulting mixture was added a solution
HOOC--(CH.sub.2).sub.16--COONSu (1.80 mg, 4.37 .mu.mol) in NMP (45
.mu.l), the reaction mixture was gently shaken for 10 min. at room
temperature, and then allowed to stand for an additional 2 h and 15
min. at room temperature. The reaction was quenched by the addition
of a solution of glycine (2.41 mg, 32.09 .mu.mol) in 50% aqueous
ethanol (241 .mu.l). The reaction mixture was purified by column
chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a
standard acetonitrile/TFA system. The column was heated to 65?C and
the acetonitrile gradient was 0-100% in 60 minutes. The title
compound (0.8 mg, 14%) was isolated, and the product was analysed
by PDMS. The m/z value for the protonated molecular ion was found
to be 3838.+-.3. The resulting molecular weight was thus 3837.+-.3
amu (theoretical value 3837 amu).
Example 14
Synthesis of Arg.sup.26,34Lys.sup.36
(N.sup.?-(?-carboxyheptadecanoyl))-GLP-1(7-36)--OH
[1320] A mixture of Arg.sup.26,34Lys.sup.36-GLP-1(7-36)--OH (24.44
mg, 7.34 .mu.mol), EDPA (26.56 mg, 205.52 .mu.mol), NMP (513 .mu.l)
and water (244.4 .mu.l) was gently shaken for 5 min. at room
temperature. To the resulting mixture was added a solution
HOOC--(CH.sub.2).sub.16--COONSu (9.06 mg, 22.02 .mu.mol) in NMP
(1.21 ml), the reaction mixture was gently shaken for 5 min. at
room temperature, and then allowed to stand for an additional 30
min. at room temperature. The reaction was quenched by the addition
of a solution of glycine (12.12 mg, 161.48 .mu.mol) in 50% aqueous
ethanol (1.21 ml). The reaction mixture was purified by column
chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a
standard acetonitrile/TFA system. The column was heated to 65?C and
the acetonitrile gradient was 0-100% in 60 minutes. The title
compound (7.5 mg, 28%) was isolated, and the product was analysed
by PDMS. The m/z value for the protonated molecular ion was found
to be 3625.+-.3. The resulting molecular weight was thus 3624.+-.3
amu (theoretical value 3624 amu).
Example 15
Synthesis of Arg.sup.26,34Lys.sup.36
(N.sup.?-(?-carboxyundecanoyl))-GLP-1(7-37)--OH
[1321] A mixture of Arg.sup.26,34Lys.sup.36-GLP-1(7-37)--OH (4.2
mg, 1.24 .mu.mol), EDPA (4.49 mg, 34.72 .mu.mol), NMP (88.2 .mu.l)
and water (42 .mu.l) was gently shaken for 10 min. at room
temperature. To the resulting mixture was added a solution
HOOC--(CH.sub.2).sub.10-COONSu (1.21 mg, 3.72 .mu.mol) in NMP
(30.25 .mu.l), the reaction mixture was gently shaken for 5 min. at
room temperature, and then allowed to stand for an additional 40
min. at room temperature. The reaction was quenched by the addition
of a solution of glycine (2.04 mg, 27.28 .mu.mol) in 50% aqueous
ethanol (204 .mu.l). The reaction mixture was purified by column
chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a
standard acetonitrile/TFA system. The column was heated to 65?C and
the acetonitrile gradient was 0-100% in 60 minutes. The title
compound (0.8 mg, 18%) was isolated, and the product was analysed
by PDMS. The m/z value for the protonated molecular ion was found
to be 3598.+-.3. The resulting molecular weight was thus 3597.+-.3
amu (theoretical value 3597 amu).
Example 16
Synthesis of
Arg.sup.26,34Lys.sup.38(N.sup.?-(?-carboxyundecanoyl))-GLP-1(7-38)--OH
[1322] A mixture of Arg.sup.26,34Lys.sup.38-GLP-1(7-38)--OH (5.168
mg, 1.46 .mu.mol), EDPA (5.28 mg, 40.88 .mu.mol), NMP (108.6 .mu.l)
and water (51.7 .mu.l) was gently shaken for 10 min. at room
temperature. To the resulting mixture was added a solution
HOOC--(CH.sub.2).sub.10-COONSu (1.43 mg, 4.38 .mu.mol) in NMP (35.8
.mu.l), the reaction mixture was gently shaken for 5 min. at room
temperature, and then allowed to stand for an additional 50 min. at
room temperature. The reaction was quenched by the addition of a
solution of glycine (2.41 mg, 32.12 .mu.mol) in 50% aqueous ethanol
(241 .mu.l). The reaction mixture was purified by column
chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a
standard acetonitrile/TFA system. The column was heated to 65?C and
the acetonitrile gradient was 0-100% in 60 minutes. The title
compound (0.85 mg, 16%) was isolated, and the product was analysed
by PDMS. The m/z value for the protonated molecular ion was found
to be 3753.+-.3. The resulting molecular weight was thus 3752.+-.3
amu (theoretical value 3752 amu).
Example 17
Synthesis of
Lys.sup.26,34bis(N.sup.?-(?-carboxyundecanoyl))-GLP-1(7-37)--OH
[1323] A mixture of GLP-1(7-37)--OH (10.0 mg, 2.98 .mu.mol), EDPA
(10.8 mg, 83.43 .mu.mol), NMP (210 .mu.l) and water (100 .mu.l) was
gently shaken for 10 min. at room temperature. To the resulting
mixture was added a solution HOOC--(CH.sub.2).sub.10-COONSu (2.92
mg, 8.94 .mu.mol) in NMP (73 .mu.l), the reaction mixture was
gently shaken for 5 min. at room temperature, and then allowed to
stand for an additional 50 min. at room temperature. The reaction
was quenched by the addition of a solution of glycine (4.92 mg,
65.56 .mu.mol) in 50% aqueous ethanol (492 .mu.l). The reaction
mixture was purified by column chromatography using a cyanopropyl
column (Zorbax 300SB-CN) and a standard acetonitrile/TFA system.
The column was heated to 65?C and the acetonitrile gradient was
0-100% in 60 minutes. The title compound (1.0 mg, 9%) was isolated,
and the product was analysed by PDMS. The m/z value for the
protonated molecular ion was found to be 3781.+-.3. The resulting
molecular weight was thus 3780.+-.3 amu (theoretical value 3780
amu).
Example 18
Synthesis of Arg.sup.26,34L
(N.sup.?-(?-carboxyundecanoyl))-GLP-1(7-36)--OH
[1324] A mixture of Arg.sup.26,34Lys.sup.36-GLP-1(7-36)--OH (15.04
mg, 4.52 .mu.mol), EDPA (16.35 mg, 126.56 .mu.mol), NMP (315.8
.mu.l) and water (150.4 .mu.l) was gently shaken for 10 min. at
room temperature. To the resulting mixture was added a solution
HOOC--(CH.sub.2).sub.10-COONSu (4.44 mg, 13.56 .mu.mol) in NMP (111
.mu.l), the reaction mixture was gently shaken for 5 min. at room
temperature, and then allowed to stand for an additional 40 min. at
room temperature. The reaction was quenched by the addition of a
solution of glycine (7.5 mg, 99.44 .mu.mol) in 50% aqueous ethanol
(750 .mu.l). The reaction mixture was purified by column
chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a
standard acetonitrile/TFA system. The column was heated to 65?C and
the acetonitrile gradient was 0-100% in 60 minutes. The title
compound (3.45 mg, 22%) was isolated, and the product was analysed
by PDMS. The m/z value for the protonated molecular ion was found
to be 3540.+-.3. The resulting molecular weight was thus 3539.+-.3
amu (theoretical value 3539 amu).
Example 19
Synthesis of Arg.sup.34Lys.sup.26
(N.sup.?-(?-carboxyundecanoyl))-1GLP-1(7-37)--OH
[1325] A mixture of Arg.sup.34-GLP-1(7-37)--OH (5.87 mg, 1.73
.mu.mol), EDPA (6.27 mg, 48.57 .mu.mol), NMP (123.3 .mu.l) and
water (58.7 .mu.l) was gently shaken for 10 min. at room
temperature. To the resulting mixture was added a solution
HOOC--(CH.sub.2).sub.10--COONSu (1.70 mg, 5.20 .mu.mol) in NMP
(42.5 .mu.l), the reaction mixture was gently shaken for 5 min. at
room temperature, and then allowed to stand for an additional 40
min. at room temperature. The reaction was quenched by the addition
of a solution of glycine (2.86 mg, 286 .mu.mol) in 50% aqueous
ethanol (286 .mu.l). The reaction mixture was purified by column
chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a
standard acetonitrile/TFA system. The column was heated to 65?C and
the acetonitrile gradient was 0-100% in 60 minutes. The title
compound (1.27 mg, 20%) was isolated, and the product was analysed
by PDMS. The m/z value for the protonated molecular ion was found
to be 3597.+-.3. The resulting molecular weight was thus 3596.+-.3
amu (theoretical value 3596 amu).
Example 20
Synthesis of Arg.sup.34Lys.sup.26
(N.sup.?-(?-carboxyheptanoyl))-GLP-1(7-37)--OH
[1326] A mixture of Arg.sup.34-GLP-1(7-37)--OH (4.472 mg, 1.32
.mu.mol), EDPA (4.78 mg, 36.96 .mu.mol), NMP (94 .mu.l) and water
(44.8 .mu.l) was gently shaken for 5 min. at room temperature. To
the resulting mixture was added a solution
HOOC--(CH.sub.2).sub.6--COONSu (1.07 mg, 3.96 .mu.mol) in NMP (26.8
.mu.l), the reaction mixture was gently shaken for 5 min. at room
temperature, and then allowed to stand for an additional 1 h and 50
min. at room temperature. The reaction was quenched by the addition
of a solution of glycine (2.18 mg, 29.04 .mu.mol) in 50% aqueous
ethanol (218 .mu.l). The reaction mixture was purified by column
chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a
standard acetonitrile/TFA system. The column was heated to 65?C and
the acetonitrile gradient was 0-100% in 60 minutes. The title
compound (0.5 mg, 11%) was isolated, and the product was analysed
by PDMS. The m/z value for the protonated molecular ion was found
to be 3540.+-.3. The resulting molecular weight was thus 3539.+-.3
amu (theoretical value 3539 amu).
Example 21
Synthesis of
Arg.sup.26,34Lys.sup.38(N.sup.?-(?-carboxyheptanoyl))-GLP-1(7-38)--OH
[1327] A mixture of Arg.sup.26,34Lys.sup.38-GLP-1(7-38)--OH (5.168
mg, 1.459 .mu.mol), EDPA (5.28 mg, 40.85 .mu.mol), NMP (108.6
.mu.l) and water (51.6 .mu.l) was gently shaken for 10 min. at room
temperature. To the resulting mixture was added a solution
HOOC--(CH.sub.2).sub.6--COONSu (1.18 mg, 4.37 .mu.mol) in NMP (29.5
.mu.l), the reaction mixture was gently shaken for 5 min. at room
temperature, and then allowed to stand for an additional 1 h and 50
min. at room temperature. The reaction was quenched by the addition
of a solution of glycine (2.40 mg, 32.09 .mu.mol) in 50% aqueous
ethanol (240 .mu.l). The reaction mixture was purified by column
chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a
standard acetonitrile/TFA system. The column was heated to 65?C and
the acetonitrile gradient was 0-100% in 60 minutes. The title
compound (0.5 mg, 9%) was isolated, and the product was analysed by
PDMS. The m/z value for the protonated molecular ion was found to
be 3697.+-.3. The resulting molecular weight was thus 3695.+-.3 amu
(theoretical value 3695 amu).
Example 22
Synthesis of Arg.sup.26,34Lys.sup.36
(N.sup.?-(?-carboxyheptanoyl))-GLP-1(7-37)--OH
[1328] A mixture of Arg.sup.26,34Lys.sup.36-GLP-1(7-37)--OH (5.00
mg, 1.47 .mu.mol), EDPA (5.32 mg, 41.16 .mu.mol), NMP (105 .mu.l)
and water (50 .mu.l) was gently shaken for 5 min. at room
temperature. To the resulting mixture was added a solution
HOOC--(CH.sub.2).sub.6--COONSu (1.19 mg, 4.41 .mu.mol) in NMP (29.8
.mu.l), the reaction mixture was gently shaken for 5 min. at room
temperature, and then allowed to stand for an additional 2 h at
room temperature. The reaction was quenched by the addition of a
solution of glycine (2.42 mg, 32.34 .mu.mol) in 50% aqueous ethanol
(242 .mu.l). The reaction mixture was purified by column
chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a
standard acetonitrile/TFA system. The column was heated to 65?C and
the acetonitrile gradient was 0-100% in 60 minutes. The title
compound (0.78 mg, 15%) was isolated, and the product was analysed
by PDMS. The m/z value for the protonated molecular ion was found
to be 3542.+-.3. The resulting molecular weight was thus 3541.+-.3
amu (theoretical value 3541 amu).
Example 23
Synthesis of Arg.sup.26,34Lys.sup.36
(N.sup.?-(?-carboxyheptanoyl))-GLP-1(7-36)--OH
[1329] A mixture of Arg.sup.26,34Lys.sup.36-GLP-1(7-36)--OH (5.00
mg, 1.50 .mu.mol), EDPA (5.44 mg, 42.08 .mu.mol), NMP (210 .mu.l)
and water (50 .mu.l) was gently shaken for 5 min. at room
temperature. To the resulting mixture was added a solution
HOOC--(CH.sub.2).sub.6--COONSu (1.22 mg, 4.5 .mu.mol) in NMP (30.5
.mu.l), the reaction mixture was gently shaken for 5 min. at room
temperature, and then allowed to stand for an additional 2 h at
room temperature. The reaction was quenched by the addition of a
solution of glycine (2.47 mg, 33.0 .mu.mol) in 50% aqueous ethanol
(247 .mu.l). The reaction mixture was purified by column
chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a
standard acetonitrile/TFA system. The column was heated to 65?C and
the acetonitrile gradient was 0-100% in 60 minutes. The title
compound (0.71 mg, 14%) was isolated, and the product was analysed
by PDMS. The m/z value for the protonated molecular ion was found
to be 3484.+-.3. The resulting molecular weight was thus 3483.+-.3
amu (theoretical value 3483 amu).
Example 24
Synthesis of
Lys26,34-bis(N.sup.?-(?-carboxyheptanoyl))-GLP-1(7-37)--OH
[1330] A mixture of GLP-1(7-37)--OH (10 mg, 2.5 .mu.mol), EDPA
(10.8 mg, 83.56 .mu.mol), NMP (210 .mu.l) and water (100 .mu.l) was
gently shaken for 10 min. at room temperature. To the resulting
mixture was added a solution HOOC--(CH.sub.2).sub.6--COONSu (2.42
mg, 8.92 .mu.mol) in NMP (60.5 .mu.l), the reaction mixture was
gently shaken for 5 min. at room temperature, and then allowed to
stand for an additional 2 h and 35 min. at room temperature. The
reaction was quenched by the addition of a solution of glycine
(4.92 mg, 65.54 .mu.mol) in 50% aqueous ethanol (492 .mu.l). The
reaction mixture was purified by column chromatography using a
cyanopropyl column (Zorbax 300SB-CN) and a standard
acetonitrile/TFA system. The column was heated to 65?C and the
acetonitrile gradient was 0-100% in 60 minutes. The title compound
(2.16 mg, 24%) was isolated, and the product was analysed by PDMS.
The m/z value for the protonated molecular ion was found to be
3669.+-.3. The resulting molecular weight was thus 3668.+-.3 amu
(theoretical value 3668 amu).
Example 25
Synthesis of Arg.sup.34Lys.sup.26
(N.sup.?-(?-carboxypentadecanoyl))-GLP-1(7-37)--OH
[1331] A mixture of Arg.sup.34-GLP-1(7-37)--OH (4.472 mg, 1.321
.mu.mol), EDPA (4.78 mg, 36.99 .mu.mol), NMP (93.9 .mu.l) and water
(44.7 .mu.l) was gently shaken for 10 min. at room temperature. To
the resulting mixture was added a solution
HOOC--(CH.sub.2).sub.14--COONSu (1.519 mg, 3.963 .mu.mol) in NMP
(38 .mu.l), the reaction mixture was gently shaken for 5 min. at
room temperature, and then allowed to stand for an additional 1 h
at room temperature. The reaction was quenched by the addition of a
solution of glycine (2.18 mg, 29.06 .mu.mol) in 50% aqueous ethanol
(218 .mu.l). The reaction mixture was purified by column
chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a
standard acetonitrile/TFA system. The column was heated to 65?C and
the acetonitrile gradient was 0-100% in 60 minutes. The title
compound (0.58 mg, 12%) was isolated, and the product was analysed
by PDMS. The m/z value for the protonated molecular ion was found
to be 3654.+-.3. The resulting molecular weight was thus 3653.+-.3
amu (theoretical value 3653 amu).
Example 26
Synthesis of Arg.sup.26,34Lys.sup.36
(N.sup.?-(?-carboxyheptanoyl))-GLP-1(7-36)--OH
[1332] A mixture of Arg.sup.26,34Lys.sup.36-GLP-1(7-36)--OH (5.00
mg, 1.50 .mu.mol), EDPA (5.44 mg, 42.08 .mu.mol), NMP (210 .mu.l)
and water (50 .mu.l) was gently shaken for 5 min. at room
temperature. To the resulting mixture was added a solution
HOOC--(CH.sub.2).sub.14--COONSu (1.72 mg, 4.5 .mu.mol) in NMP (43
.mu.l), the reaction mixture was gently shaken for 5 min. at room
temperature, and then allowed to stand for an additional 1 h at
room temperature. The reaction was quenched by the addition of a
solution of glycine (2.48 mg, 33 .mu.mol) in 50% aqueous ethanol
(248 .mu.l). The reaction mixture was purified by column
chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a
standard acetonitrile/TFA system. The column was heated to 65?C and
the acetonitrile gradient was 0-100% in 60 minutes. The title
compound (0.58 mg, 11%) was isolated, and the product was analysed
by PDMS. The m/z value for the protonated molecular ion was found
to be 3596.+-.3. The resulting molecular weight was thus 3595.+-.3
amu (theoretical value 3595 amu).
Example 27
Synthesis of lithocholic acid 2,5-dioxo-pyrrolidin-1-yl ester
[1333] To a mixture of lithocholic acid (5.44 g, 14.34 mmol),
N-hydroxysuccinimide (1.78 g, 15.0 mmol), anhydrous THF (120 ml)
and anhydrous acetonitrile (30 ml), kept at to 10 ?C, was added a
solution of N,N'-dicyclohexylcarbodiimide (3.44 g, 16.67 mmol) in
anhydrous THF. The reaction mixture was stirred at ambient
temperature for 16 h, filtered and concentrated in vacuo. The
residue was dissolved in dichloromethane (450 ml), washed with a
10% aqueous Na.sub.2CO.sub.3 solution (2.times.150 ml) and water
(2.times.150 ml), and dried (MgSO.sub.4). Filtered and the filtrate
concentrated in vacuo to give a crystalline residue. The residue
was recrystallised from a mixture of dichloromethane (30 ml) and
n-heptane (30 ml to give the title compound (3.46 g, 51%) as a
crystalline solid.
Example 28
Synthesis of
Arg.sup.34Lys26(N.sup.?-lithocholyl)-GLP-1(7-37)--OH
[1334] A mixture of Arg.sup.34-GLP-1(7-37)--OH (4.472 mg, 1.32
.mu.mol), EDPA (4.78 mg, 36.96 .mu.mol), NMP (94 .mu.l) and water
(44.8 .mu.l) was gently shaken for 10 min. at room temperature. To
the resulting mixture was added a solution of lithocholic acid
2,5-dioxo-pyrrolidin-1-yl ester (1.87 mg, 3.96 .mu.mol) in NMP
(46.8 .mu.l), the reaction mixture was gently shaken for 5 min. at
room temperature, and then allowed to stand for an additional 1 h
at room temperature. The reaction was quenched by the addition of a
solution of glycine (2.18 mg, 29.04 .mu.mol) in 50% aqueous ethanol
(218 .mu.l). The reaction mixture was purified by column
chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a
standard acetonitrile/TFA system. The column was heated to 65?C and
the acetonitrile gradient was 0-100% in 60 minutes. The title
compound (1.25 mg, 25%) was isolated, and the product was analysed
by PDMS. The m/z value for the protonated molecular ion was found
to be 3744.+-.3. The resulting molecular weight was thus 3743.+-.3
amu (theoretical value 3743 amu).
Example 29
Synthesis of N.sup.?-tetradecanoyl-Glu(ONSu)-OBu.sup.t
[1335] To a suspension of H-Glu(OH)--OBu.sup.t(2.5 g, 12.3 mmol),
DMF (283 ml) and EDPA (1.58 g, 12.3 mmol) was added drop by drop a
solution of Myr-ONSu (4.0 g, 12.3 mmol) in DMF (59 ml). The
reaction mixture was stirred for 16 h at room temperature and then
concentrated in vacuo to a total volume of 20 ml. The residue was
partitioned between 5% aqueous citric acid (250 ml) and ethyl
acetate (150 ml), and the phases were separated. The organic phase
was concentrated in vacuo and the residue dissolved in DMF (40 ml).
The resulting solution was added drop by drop to a 10% aqueous
solution of citric acid (300 ml) kept at 0?C. The precipitated
compound was collected and washed with iced water and dried in a
vacuum drying oven. The dried compound was dissolved in DMF (23 ml)
and HONSu (1.5 g, 13 mmol) was added. To the resulting mixture was
added a solution of N,N'-dicyclohexylcarbodiimide (2.44 g, 11.9
mmol) in dichloromethane (47 ml). The reaction mixture was stirred
for 16 h at room temperature, and the precipitated compound was
filtered off. The precipitate was recrystallised from
n-heptane/2-propanol to give the title compound (3.03 g, 50%).
Example 30
Synthesis of
Glu.sup.22,23,30Arg.sup.26,34Lys.sup.38(N.sup.?-(?-glutamyl(N.sup.?-tetra-
decanoyl)))-GLP-1(7-38)--OH
[1336] A mixture of
Glu.sup.22,23,30Arg.sup.26,34Lys38-GLP-1(7-38)--OH (1.0 mg, 0.272
.mu.mol), EDPA (0.98 mg, 7.62 .mu.mol), NMP (70 .mu.l) and water
(70 .mu.l) was gently shaken for 5 min. at room temperature. To the
resulting mixture was added a solution of
N.sup.?-tetradecanoyl-Glu(ONSu)-OBu.sup.t, prepared as described in
Example 29, (0.41 mg, 0.816 .mu.mol) in NMP (10.4 .mu.l), the
reaction mixture was gently shaken for 5 min. at room temperature,
and then allowed to stand for an additional 45 min. at room
temperature. The reaction was quenched by the addition of a
solution of glycine (0.448 mg, 5.98 .mu.mol) in 50% aqueous ethanol
(45 .mu.l). A 0.5% aqueous solution of ammonium acetate (0.9 ml)
was added, and the resulting mixture was immobilised on a Varian
500 mg C8 Mega Bond Elut.RTM. cartridge, the immobilised compound
washed with 5% aqueous acetonitrile (10 ml), and finally liberated
from the cartridge by elution with TFA (10 ml). The eluate was
concentrated in vacuo, and the reaction mixture was purified by
column chromatography using a cyanopropyl column (Zorbax 300SB-CN)
and a standard acetonitrile/TFA system. The column was heated to
65?C and the acetonitrile gradient was 0-100% in 60 minutes. The
title compound (0.35 mg, 32%) was isolated, and the product was
analysed by PDMS. The m/z value for the protonated molecular ion
was found to be 4012.+-.3. The resulting molecular weight was thus
4011.+-.3 amu (theoretical value 4011 amu).
Example 31
Synthesis of
Glu.sup.23,26Arg.sup.34Lys.sup.38(N.sup.?-(?-glutamyl(N.sup.?-tetradecano-
yl)))-GLP-1(7-38)--OH
[1337] A mixture of
Glu.sup.23,26Arg.sup.34Lys.sup.38-GLP-1(7-38)--OH (6.07 mg, 1.727
.mu.mol), EDPA (6.25 mg, 48.36 .mu.mol), NMP (425 .mu.l) and water
(425 .mu.l) was gently shaken for 5 min. at room temperature. To
the resulting mixture was added a solution of
N.sup.?-tetradecanoyl-Glu(ONSu)-OBu.sup.t, prepared as described in
example 29, (2.65 mg, 5.18 .mu.mol) in NMP (66.3 .mu.l), the
reaction mixture was gently shaken for 5 min. at room temperature,
and then allowed to stand for an additional 45 mm. at room
temperature. The reaction was quenched by the addition of a
solution of glycine (2.85 mg, 38.0 .mu.mol) in 50% aqueous ethanol
(285 .mu.l). A 0.5% aqueous solution of ammonium acetate (5.4 ml)
was added, and the resulting mixture was immobilised on a Varian
500 mg C8 Mega Bond Elut.RTM. cartridge, the immobilised compound
washed with 5% aqueous acetonitrile (10 ml), and finally liberated
from the cartridge by elution with TFA (10 ml). The eluate was
concentrated in vacuo, and the reaction mixture was purified by
column chromatography using a cyanopropyl column (Zorbax 300SB-CN)
and a standard acetonitrile/TFA system. The column was heated to
65?C and the acetonitrile gradient was 0-100% in 60 minutes. The
title compound (0.78 mg, 12%) was isolated, and the product was
analysed by PDMS. The m/z value for the protonated molecular ion
was found to be 3854.+-.3. The resulting molecular weight was thus
3853.+-.3 amu (theoretical value 3853 amu).
Example 32
Synthesis of
Lys.sup.26,34-bis(N.sup.?-(?-carboxytridecanoyl))-GLP-1(7-37)--OH
[1338] A mixture of GLP-1(7-37)--OH (30 mg, 8.9 .mu.mol), EDPA
(32.3 mg, 250 .mu.mol), NMP (2.1 ml) and water (2.1 ml) was gently
shaken for 5 min. at room temperature. To the resulting mixture was
added a solution HOOC--(CH.sub.2).sub.12--COONSu (12.7 mg, 35.8
.mu.mol) in NMP (318 ?l), the reaction mixture was gently shaken
for 1 h and 40 min. at room temperature. The reaction was quenched
by the addition of a solution of glycine (3.4 mg, 44.7 .mu.mol) in
50% aqueous ethanol (335 .mu.l). The reaction mixture was purified
by column chromatography using a cyanopropyl column (Zorbax
300SB-CN) and a standard acetonitrile/TFA system. The column was
heated to 65?C and the acetonitrile gradient was 0-100% in 60
minutes. The title compound (10 mg, 29%) was isolated, and the
product was analysed by PDMS. The m/z value for the protonated
molecular ion was found to be 3840.+-.3. The resulting molecular
weight was thus 3839.+-.3 amu (theoretical value 3839 amu).
Example 33
Synthesis of
Lys.sup.26,34-bis(N.sup.?-(?-glutamyl(N.sup.?-tetradecanoyl)))-GLP-1(7-37-
)--OH
[1339] A mixture of GLP-1(7-37)--OH (300 mg, 79.8 .mu.mol), EDPA
(288.9 mg, 2.24 mmol), NMP (21 ml) and water (21 ml) was gently
shaken for 5 min. at room temperature. To the resulting mixture was
added a solution of N.sup.?-tetradecanoyl-Glu(ONSu)-OBu.sup.t,
prepared as described in Example 29, (163 mg, 319.3 .mu.mol) in NMP
(4.08 ml), the reaction mixture was gently shaken for 5 min. at
room temperature, and then allowed to stand for an additional 1 h
at room temperature. The reaction was quenched by the addition of a
solution of glycine (131.8 mg, 1.76 mmol) in 50% aqueous ethanol
(13.2 ml). A 0.5% aqueous solution of ammonium-acetate (250 ml) was
added, and the resulting mixture was divided into four equal
portions. Each portion was eluted onto a Varian 500 mg C8 Mega Bond
Elut.RTM. cartridge, the immobilised compound washed with 0.1%
aqueous TFA (3.5 ml), and finally liberated from the cartridge by
elution with 70% aqueous acetonitrile (4 ml). The combined eluates
were diluted with 0.1% aqueous TFA (300 ml). The precipitated
compound was collected by centrifugation, washed with 0.1% aqueous
TFA (50 ml), and finally isolated by centrifugation. To the
precipitate was added TFA (60 ml), and the resulting reaction
mixture was stirred for 1 h and 30 min. at room temperature. Excess
TFA was removed in vacuo, and the residue was poured into water (50
ml). The precipitated compound was purified by column
chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a
standard acetonitrile/TFA system. The column was heated to 65?C and
the acetonitrile gradient was 0-100% in 60 minutes. The title
compound (27.3 mg, 8%) was isolated, and the product was analysed
by PDMS. The m/z value for the protonated molecular ion was found
to be 4036.+-.3. The resulting molecular weight was thus 4035.+-.3
amu (theoretical value 4035 amu).
Example 34
Synthesis of
Arg.sup.26,34Lys.sup.38(N.sup.?-(?-carboxypentadecanoyl))-GLP-1(7-38)--OH
[1340] A mixture of Arg.sup.26,34Lys.sup.38-GLP-1(7-38)--OH (30 mg,
8.9 .mu.mol), EDPA (32.3 mg, 250 .mu.mol), NMP (2.1 ml) and water
(2.1 ml) was gently shaken for 5 min. at room temperature. To the
resulting mixture was added a solution
HOOC--(CH.sub.2).sub.14--COONSu (13.7 mg, 35.8 .mu.mol) in NMP (343
?l), the reaction mixture was gently shaken for 1 h at room
temperature. The reaction was quenched by the addition of a
solution of glycine (3.4 mg, 44.7 .mu.mol) in 50% aqueous ethanol
(335 .mu.l). The reaction mixture was purified by column
chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a
standard acetonitrile/TFA system. The column was heated to 65?C and
the acetonitrile gradient was 0-100% in 60 minutes. The title
compound (4.8 mg, 14%) was isolated, and the product was analysed
by PDMS. The m/z value for the protonated molecular ion was found
to be 3894.+-.3. The resulting molecular weight was thus 3893.+-.3
amu (theoretical value 3893 amu).
Example 35
Synthesis of N.sup.?-hexadecanoyl-Glu(ONSu)-OBu.sup.t
[1341] To a suspension of H-Glu(OH)--OBu.sup.t(4.2 g, 20.6 mmol),
DMF (500 ml) and EDPA (2.65 g, 20.6 mmol) was added drop by drop a
solution of Pal-ONSu (7.3 g, 20.6 mmol) in DMF (100 ml). The
reaction mixture was stirred for 64 h at room temperature and then
concentrated in vacuo to a total volume of 20 ml. The residue was
partitioned between 10% aqueous citric acid (300 ml) and ethyl
acetate (250 ml), and the phases were separated. The organic phase
was concentrated in vacuo and the residue dissolved in DMF (50 ml).
The resulting solution was added drop by drop to a 10% aqueous
solution of citric acid (500 ml) kept at 0?C. The precipitated
compound was collected and washed with iced water and dried in a
vacuum drying oven. The dried compound was dissolved in DMF (45 ml)
and HONSu (2.15 g, 18.7 mmol) was added. To the resulting mixture
was added a solution of N,N'-dicyclohexylcarbodiimide (3.5 g, 17
mmol) in dichloromethane (67 ml). The reaction mixture was stirred
for 16 h at room temperature, and the precipitated compound was
filtered off. The precipitate was recrystallised from
n-heptane/2-propanol to give the title compound (6.6 g, 72%).
Example 36
Synthesis of
Lys.sup.26,34-bis(N-(?-glutamyl(N.sup.?-hexadecanoyl)))-GLP-1(7-37)--OH
[1342] A mixture of GLP-1(7-37)--OH (10 mg, 2.9 .mu.mol), EDPA
(10.8 mg, 83.4 ?mol), NMP (0.7 ml) and water (0.7 ml) was gently
shaken for 5 min. at room temperature. To the resulting mixture was
added a solution of N.sup.?-hexadecanoyl-Glu(ONSu)-OBu.sup.t,
prepared as described in Example 33, (163 mg, 319.3 .mu.mol) in NMP
(4.08 ml), the reaction mixture was gently shaken 1 h and 20 min.
at room temperature. The reaction was quenched by the addition of a
solution of glycine (4.9 mg, 65.6 .mu.mol) in 50% aqueous ethanol
(492 ?l). A 0.5% aqueous solution of ammonium-acetate (9 ml) was
added, and the resulting mixture eluted onto a Varian 1 g C8 Mega
Bond Elut.RTM. cartridge, the immobilised compound washed with 5%
aqueous acetonitrile (10 ml), and finally liberated from the
cartridge by elution with TFA (10 ml). The eluate was concentrated
in vacuo, and the residue purified by column chromatography using a
cyanopropyl column (Zorbax 300SB-CN) and a standard
acetonitrile/TFA system. The column was heated to 65?C and the
acetonitrile gradient was 0-100% in 60 minutes. The title compound
(2.4 mg, 20%) was isolated, and the product was analysed by PDMS.
The m/z value for the protonated molecular ion was found to be
4092.+-.3. The resulting molecular weight was thus 409.+-.3 amu
(theoretical value 4091 amu).
Example 37
Synthesis of
Arg.sup.34Lys.sup.26(N.sup.?-(?-glutamyl(N.sup.?-hexadecanoyl)))-GLP-1(7--
37)--OH
[1343] A mixture of Arg.sup.34-GLP-1(7-37)--OH (3.7 mg, 1.1
.mu.mol), EDPA (4.0 mg, 30.8 ?mol), acetonitrile (260 ?l) and water
(260 ?l) was gently shaken for 5 min. at room temperature. To the
resulting mixture was added a solution of
N.sup.?-hexadecanoyl-Glu(ONSu)-OBu.sup.t, prepared as described in
Example 35, (1.8 mg, 3.3 .mu.mol) in acetonitrile (44.2 ?l), and
the reaction mixture was gently shaken for 1 h and 20 min. at room
temperature. The reaction was quenched by the addition of a
solution of glycine (1.8 mg, 24.2 .mu.mol) in 50% aqueous ethanol
(181 ?l). A 0.5% aqueous solution of ammonium-acetate (12 ml) and
NMP (300 ?l) were added, and the resulting mixture eluted onto a
Varian 1 g C8 Mega Bond Elut.RTM. cartridge, the immobilised
compound washed with 5% aqueous acetonitrile (10 ml), and finally
liberated from the cartridge by elution with TFA (6 ml). The eluate
was allowed to stand for 2 h at room temperature and then
concentrated in vacuo. The residue was purified by column
chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a
standard acetonitrile/TFA system. The column was heated to 65?C and
the acetonitrile gradient was 0-100% in 60 minutes. The title
compound (0.23 mg, 6%) was isolated, and the product was analysed
by PDMS. The m/z value for the protonated molecular ion was found
to be 3752.+-.3. The resulting molecular weight was thus 3751.+-.3
amu (theoretical value 3751 amu).
Example 38
Synthesis of
Arg.sup.263Lys.sup.38(N.sup.?-(?-glutamyl(N.sup.?-tetradecanoyl)))-GLP-1(-
7-38)--OH
[1344] A mixture of Arg.sup.26,34Lys.sup.38-GLP-1(7-38)--OH (14 mg,
4.0 .mu.mol), EDPA (14.3 mg, 110.6 ?mol), NMP (980 ?l) and water
(980 ?l) was gently shaken for 5 min. at room temperature. To the
resulting mixture was added a solution of
N.sup.?-tetradecanoyl-Glu(ONSu)-OBu.sup.t, prepared as described in
Example 29, (12.1 mg, 23.7 .mu.mol) in NMP (303 ?l), and the
reaction mixture was gently shaken for 2 h at room temperature. The
reaction was quenched by the addition of a solution of glycine (6.5
mg, 86.9 mmol) in 50% aqueous ethanol (652 ?l). A 0.5% aqueous
solution of ammonium-acetate (50 ml) was added, and the resulting
mixture eluted onto a Varian 1 g C8 Mega Bond Elut.RTM. cartridge,
the immobilised compound washed with 5% aqueous acetonitrile (15
ml), and finally liberated from the cartridge by elution with TFA
(6 ml). The eluate was allowed to stand for 1 h and 45 min. at room
temperature and then concentrated in vactuo. The residue was
purified by column chromatography using a cyanopropyl column
(Zorbax 300SB-CN) and a standard acetonitrile/TFA system. The
column was heated to 65?C and the acetonitrile gradient was 0-100%
in 60 minutes. The title compound (3.9 mg, 26%) was isolated, and
the product was analysed by PDMS. The m/z value for the protonated
molecular ion was found to be 3881.+-.3. The resulting molecular
weight was thus 3880.+-.3 amu (theoretical value 3880 amu).
Example 39
Synthesis of
Arg.sup.26,34Lys.sup.38(N.sup.?-(?-carboxypentadecanoyl))-GLP-1(7-38)--OH
[1345] A mixture of Arg.sup.26,34Lys.sup.38-GLP-1(7-38)--OH (14 mg,
4.0 .mu.mol), EDPA (14.3 mg, 111 .mu.mol), NMP (980 ?l) and water
(980 ?l) was gently shaken for 5 min. at room temperature. To the
resulting mixture was added a solution of
HOOC--(CH.sub.2).sub.14--COONSu (4.5 mg, 11.9 .mu.mol) in NMP (114
?l), the reaction mixture was gently shaken for 1 h and 45 min. at
room temperature. An additional solution of
HOOC--(CH.sub.2).sub.14--COONSu (4.0 mg, 10.4 mmol) in NMP (100 ?l)
was added, and the resulting mixture was gently shaken for an
additional 1 h and 30 min. at room temperature. The reaction was
quenched by the addition of a solution of glycine (1.5 mg, 19.8
.mu.mol) in 50% aqueous ethanol (148 .mu.l). The reaction mixture
was purified by column chromatography using a cyanopropyl column
(Zorbax 300SB-CN) and a standard acetonitrile/TFA system. The
column was heated to 65?C and the acetonitrile gradient was 0-100%
in 60 minutes. The title compound (3.9 mg, 26%) was isolated, and
the product was analysed by PDMS. The m/z value for the protonated
molecular ion was found to be 3809.+-.3. The resulting molecular
weight was thus 3808.+-.3 amu (theoretical value 3808 amu).
Example 40
Synthesis of
Arg.sup.26,34Lys.sup.38(N.sup.?-(?-glutamyl(N.sup.?-hexadecanoyl)))-GLP-1-
(7-38)--OH
[1346] A mixture of Arg.sup.26,34Lys.sup.38-GLP-1(7-38)--OH (14 mg,
4.0 .mu.mol), EDPA (14.3 mg, 110.6 ?mol), NMP (980 ?l) and water
(980 ?l) was gently shaken for 5 min. at room temperature. To the
resulting mixture was added a solution of
N.sup.?-hexadecanoyl-Glu(ONSu)-OBu.sup.t, prepared as described in
Example 35, (6.4 mg, 11.9 .mu.mol) in NMP (160 ?l), and the
reaction mixture was gently shaken for 1 h and 20 min. at room
temperature. The reaction was quenched by the addition of a
solution of glycine (6.5 mg, 87 mmol) in 50% aqueous ethanol (653
?l). A 0.5% aqueous solution of ammonium-acetate (50 ml) was added,
and the resulting mixture eluted onto a Varian 1 g C8 Mega Bond
Elut.RTM. cartridge, the immobilised compound washed with 5%
aqueous acetonitrile (10 ml), and finally liberated from the
cartridge by elution with TFA (6 ml). The eluate was allowed to
stand for 1 h and 30 min. at room temperature and then concentrated
in vacuo. The residue was purified by column chromatography using a
cyanopropyl column (Zorbax 300SB-CN) and a standard
acetonitrile/TFA system. The column was heated to 65?C and the
acetonitrile gradient was 0-100% in 60 minutes. The title compound
(7.2 mg, 47%) was isolated, and the product was analysed by PDMS.
The m/z value for the protonated molecular ion was found to be
3881.+-.3. The resulting molecular weight was thus 3880.+-.3 amu
(theoretical value 3880 amu).
Example 41
Synthesis of
Arg.sup.18,23,26,30,34Lys.sup.38(N.sup.?-hexadecanoyl)-GLP-1(7-38)--OH
[1347] A mixture of
Arg.sup.18,23,26,30,34Lys.sup.38-GLP-1(7-38)--OH (1.0 mg, 0.27
.mu.mol), EDPA (0.34 mg, 2.7 .mu.mol) and DMSO (600 .mu.l) was
gently shaken for 5 min. at room temperature. To the resulting
mixture was added a solution of Pal-ONSu (0.28 mg, 0.8 .mu.mol) in
NMP (7 .mu.l). The reaction mixture was gently shaken for 5 min. at
room temperature, and then allowed to stand for an additional 6 h
at room temperature. The reaction was quenched by the addition of a
solution of glycine (1.6 mg, 21.7 .mu.mol) in 50% aqueous ethanol
(163 .mu.l). The reaction mixture was purified by column
chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a
standard acetonitrile/TFA system. The column was heated to 65?C and
the acetonitrile gradient was 0-100% in 60 minutes. The title
compound (0.17 mg, 16%) was isolated, and the product was analysed
by MALDI-MS. The m/z value for the protonated molecular ion was
found to be 3961.+-.3. The resulting molecular weight was thus
3960.+-.3 amu (theoretical value 3960 amu).
Example 42
Synthesis of
Arg.sup.26,34Lys.sup.38(N.sup.?-(?-carboxytridecanoyl))-GLP-1(7-38)--OH
[1348] A mixture of Arg.sup.26,34Lys.sup.38-GLP-1(7-38)--OH (14 mg,
4.0 .mu.mol), EDPA (14.3 mg, 111 .mu.mol), NMP (980 ?l) and water
(980 ?l) was gently shaken for 5 min. at room temperature. To the
resulting mixture was added a solution of
HOOC--(CH.sub.2).sub.12--COONSu (4.2 mg, 11.9 .mu.mol) in NMP (105
?l), the reaction mixture was gently shaken for 1 h and 50 min. at
room temperature. The reaction was quenched by the addition of a
solution of glycine (6.5 mg, 87 .mu.mol) in 50% aqueous ethanol
(652 .mu.l). The reaction mixture was purified by column
chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a
standard acetonitrile/TFA system. The column was heated to 65?C and
the acetonitrile gradient was 0-100% in 60 minutes. The title
compound (5.8 mg, 39%) was isolated, and the product was analysed
by MALDI-MS. The m/z value for the protonated molecular ion was
found to be 3780.+-.3. The resulting molecular weight was thus
3779.+-.3 amu (theoretical value 3781 amu).
Example 43
Synthesis of
Arg.sup.34Lys26(N.sup.?-(?-glutamyl(N.sup.?-tetradecanoyl)))-GLP-1(7-37)--
-OH
[1349] A mixture of Arg.sup.34-GLP-1(7-37)--OH (15 mg, 4.4
.mu.mol), EDPA (16 mg, 124 ?mol), NMP (2 ml) and water (4.8 ml) was
gently shaken for 5 min. at room temperature. To the resulting
mixture was added a solution of
N.sup.?-tetradecanoyl-Glu(ONSu)-OBu.sup.t, prepared as described in
Example 29, (12.1 mg, 23.7 .mu.mol) in NMP (303 ?l), and the
reaction mixture was gently shaken for 2 h at room temperature. The
reaction was quenched by the addition of a solution of glycine (6.5
mg, 86.9 .mu.mol) in 50% aqueous ethanol (652 ?l). A 0.5% aqueous
solution of ammonium-acetate (50 ml) was added, and the resulting
mixture eluted onto a Varian 1 g C8 Mega Bond Elut.RTM. cartridge,
the immobilised compound washed with 5% aqueous acetonitrile (15
ml), and finally liberated from the cartridge by elution with TFA
(6 ml). The eluate was allowed to stand for 1 h and 45 min. at room
temperature and then concentrated in vacuo. The residue was
purified by column chromatography using a cyanopropyl column
(Zorbax 300SB-CN) and a standard acetonitrile/TFA system. The
column was heated to 65?C and the acetonitrile gradient was 0-100%
in 60 minutes. The title compound (3.9 mg, 26%) was isolated, and
the product was analysed by MALDI-MS. The m/z value for the
protonated molecular ion was found to be 3723.+-.3. The resulting
molecular weight was thus 3722.+-.3 amu (theoretical value 3723
amu).
Example 44
Synthesis of N.sup.?-octadecanoyl-Glu(ONSu)-OBu.sup.t
[1350] To a suspension of H-Glu(OH)--OBu.sup.t(2.82 g, 13.9 mmol),
DMF (370 ml) and EDPA (1.79 g, 13.9 mmol) was added drop by drop a
solution of Ste-ONSu (5.3 g, 13.9 mmol) in DMF (60 ml).
Dichloromethane (35 ml) was added, and the reaction mixture was
stirred for 24 h at room temperature and then concentrated in
vacuo. The residue was partitioned between 10% aqueous citric acid
(330 ml) and ethyl acetate (200 ml), and the phases were separated.
The organic phase was concentrated in vacuo and the residue
dissolved in DMF (60 ml). The resulting solution was added drop by
drop to a 10% aqueous solution of citric acid (400 ml) kept at 0?C.
The precipitated compound was collected and washed with iced water
and dried in a vacuum drying oven. The dried compound was dissolved
in DMF (40 ml) and HONSu (1.63 g, 14.2 mmol) was added. To the
resulting mixture was added a solution of DCC (2.66 g, 12.9 mmol)
in dichloromethane (51 ml). The reaction mixture was stirred for 64
h at room temperature, and the precipitated compound was filtered
off. The precipitate was recrystallised from n-heptane/2-propanol
to give the title compound (4.96 g, 68%).
Example 45
Synthesis of
Arg.sup.26,34Lys.sup.38(N.sup.?-(?-glutamyl(N.sup.?-octadecanoyl)))-GLP-1-
(7-38)--OH
[1351] A mixture of Arg.sup.26,34-GLP-1(7-38)--OH (28 mg, 7.9
.mu.mol), EDPA (28.6 mg, 221.5 ?mol), NMP (1.96 ml) and water (1.96
ml) was gently shaken for 5 min. at room temperature. To the
resulting mixture was added a solution of
N.sup.?-octadecanoyl-Glu(ONSu)-OBu.sup.t(17.93 g, 31.6 ?mol),
prepared as described in Example 44, in NMP (448 ?l), and the
reaction mixture was gently shaken for 2 h at room temperature. The
reaction was quenched by the addition of a solution of glycine
(13.1 mg, 174 ?mol) in 50% aqueous ethanol (1.3 ml). A 0.5% aqueous
solution of ammonium-acetate (120 ml) was added, and the resulting
mixture was divided into two equal portions. Each portion was
eluted onto a Varian 5 g C8 Mega Bond Elut.RTM. cartridge, the
immobilised compound washed with 5% aqueous acetonitrile (25 ml),
and finally liberated from the cartridge by elution TFA (25 ml).
The combined eluates were allowed to stand for 1 h and 25 min. at
room temperature and then concentrated in vacuo. The residue was
purified by column chromatography using a cyanopropyl column
(Zorbax 300SB-CN) and a standard acetonitrile/TFA system. The
column was heated to 65?C and the acetonitrile gradient was 0-100%
in 60 minutes. The title compound (3.6 mg, 11%) was isolated, and
the product was analysed by MALDI-MS. The m/z value for the
protonated molecular ion was found to be 3940.+-.3. The resulting
molecular weight was thus 3939.+-.3 amu (theoretical value 3937
amu).
Biological Findings
Protraction of GLP-1 Derivatives After s.c. Administration
[1352] The protraction of a number GLP-1 derivatives of the
invention was determined by monitoring the concentration thereof in
plasma after sc administration to healthy pigs, using the method
described below. For comparison also the concentration in plasma of
GLP-1(7-37) after sc. administration was followed. The results are
given in Table 1. The protraction of other GLP-1 derivatives of the
invention can be determined in the same way.
[1353] Pigs (50% Duroc, 25% Yorkshire, 25% Danish Landrace, app 40
kg) were fasted from the beginning of the experiment. To each pig
0.5 nmol of test compound per kg body weight was administered in a
50 .mu.M isotonic solution (5 mM phosphate, pH 7.4, 0.02%
Tween.RTM.-20 (Merck), 45 mg/ml mannitol (pyrogen free, Novo
Nordisk). Blood samples were drawn from a catheter in vena
jugularis at the hours indicated in Table 1. 5 ml of the blood
samples were poured into chilled glasses containing 175 .mu.l of
the following solution: 0.18 M EDTA, 1500 KIE/ml aprotinin (Novo
Nordisk) and 3% bacitracin (Sigma), pH 7.4. Within 30 min, the
samples were centrifuged for 10 min at 5-6000*g. Temperature was
kept at 4?C. The supernatant was pipetted into different glasses
and kept at minus 20?C until use.
[1354] The plasma concentrations of the peptides were determined by
RIA using a monoclonal antibody specific for the N-terminal region
of GLP-1(7-37). The cross reactivities were less than 1% with
GLP-1(1-37) and GLP-1(8-36)amide and <0.1% with GLP-1(9-37),
GLP-1(10-36)amide and GLP-1(11-36)amide. The entire procedure was
carried out at 4?C.
[1355] The assay was carried out as follows: 100 .mu.l plasma was
mixed with 271 .mu.l 96% ethanol, mixed using a vortex mixer and
centrifuged at 2600*g for 30 min. The supernatant was decanted into
Minisorp tubes and evaporated completely (Savant Speedvac AS290).
The evaporation residue was reconstituted in the assay buffer
consisting of 80 mM NaH.sub.2PO.sub.4/Na.sub.2HPO.sub.4, 0.1% HSA
(Orpha 20/21, Behring), 10 mM EDTA, 0.6 mM thiomersal (Sigma), pH
7.5. Samples were reconstituted in volumes suitable for their
expected concentrations, and were allowed to reconstitute for 30
min. To 300 .mu.l sample, 100 .mu.l antibody solution in dilution
buffer containing 40 mM NaH.sub.2PO.sub.4/Na.sub.2HPO.sub.4, 0.1%
HSA, 0.6 mM thiomersal, pH 7.5, was added. A non-specific sample
was prepared by mixing 300 .mu.l buffer with 100 .mu.l dilution
buffer. Individual standards were prepared from freeze dried
stocks, dissolved in 300 .mu.l assay buffer. All samples were
pre-incubated in Minisorp tubes with antibody as described above
for 72 h. 200 .mu.l tracer in dilution buffer containing 6-7000 CPM
was added, samples were mixed and incubated for 48 h. 1.5 ml of a
suspension of 200 ml per litre of heparin-stabilised bovine plasma
and 18 g per litre of activated carbon (Merck) in 40 mM
NaH.sub.2PO.sub.4/Na.sub.2HPO.sub.4, 0.6 mM thiomersal, pH 7.5, was
added to each tube. Before use, the suspension was mixed and
allowed to stand for 2 h at 4?C. All samples were incubated for 1 h
at 4?C and then centrifuged at 3400*g for 25 min. Immediately after
the centrifugation, the supernatant was decanted and counted in a
?-counter. The concentration in the samples was calculated from
individual standard curves. The following plasma concentrations
were found, calculated as % of the maximum concentration for the
individual compounds (n=2): TABLE-US-00003 TABLE 1 Test com- Hours
after sc. Administration pound*.sup.) 0.75 1 2 4 6 8 10 12 24 GLP-1
100 9 1 (7-37) Exam- 73 92 100 98 82 24 16 16 16 ple 25 Exam- 76 71
91 100 84 68 30 9 ple 17 Exam- 39 71 93 100 91 59 50 17 ple 43
Exam- 26 38 97 100 71 81 80 45 ple 37 Exam- 24 47 59 71 100 94 100
94 ple 11 Exam- 36 54 65 94 80 100 85 93 ple 12 Exam- 55 53 90 83
88 70 98 100 100 ple 32 Exam- 18 25 32 47 98 83 97 100 ple 14 Exam-
15 22 38 59 97 85 100 76 ple 13 Exam- 60 53 100 66 48 39 25 29 0
ple 38 Exam- 38 100 70 47 33 33 18 27 14 ple 39 Exam- 47 19 50 100
51 56 34 14 0 ple 40 Exam- 19 32 44 84 59 66 83 84 100 ple 34
*.sup.)The test compounds are the title compounds of the examples
with the numbers given
[1356] Table 1 shows that the GLP-1 derivatives of the invention
have a protracted profile of action relative to GLP-1(7-37) and are
much more persistent in plasma than GLP-1(7-37). It also appears
from Table 1 that the time at which the peak concentration in
plasma is achieved varies within wide limits, depending on the
particular GLP-1 derivative selected.
Stimulation of cAMP Formation in a Cell Line Expressing the Cloned
Human GLP-1 Receptor
[1357] In order to demonstrate efficacy of the GLP-1 derivatives,
their ability to stimulate formation of cAMP in a cell line
expressing the cloned human GLP-1 receptor was tested. An EC.sub.50
was calculated from the dose-response curve.
[1358] Baby hamster kidney (BHK) cells expressing the human
pancreatic GLP-1 receptor were used (Knudsen and Pridal, 1996, Eur.
J. Pharm. 318, 429-435). Plasma membranes were prepared (Adelhorst
et al, 1994, J. Biol. Chem. 269, 6275) by homogenisation in buffer
(10 mmol/l Tris-HCl and 30 mmol/l NaCl pH 7.4, containing, in
addition, 1 mmol/l dithiothreitol, 5 mg/l leupeptin (Sigma, St.
Louis, Mo., USA), 5 mg/l pepstatin (Sigma, St. Louis, Mo., USA),
100 mg/l bacitracin (Sigma, St. Louis, Mo., USA), and 16 mg/l
aprotinin (Novo Nordisk A/S, Bagsvaerd, Denmark)). The homogenate
was centrifuged on top of a layer of 41 w/v % sucrose. The white
band between the two layers was diluted in buffer and centrifuged.
Plasma membranes were stored at -80?C until used.
[1359] The assay was carried out in 96-well microtiter plates in a
total volume of 140 .mu.l. The buffer used was 50 mmol/l Tris-HCl,
pH 7.4 with the addition of 1 mmol/l EGTA, 1.5 mmol/l MgSO.sub.4,
1.7 mmol/l ATP, 20 mM GTP, 2 mmol/l 3-isobutyl-1-methylxanthine,
0.01% Tween-20 and 0.1% human serum albumin (Reinst, Behringwerke A
G, Marburg, Germany). Compounds to be tested for agonist activity
were dissolved and diluted in buffer, added to the membrane
preparation and the mixture was incubated for 2 h at 37?C. The
reaction was stopped by the addition of 25 .mu.l of 0.05 mol/l HCl.
Samples were diluted 10 fold before analysis for cAMP by a
scintillation proximity assay (RPA 538, Amersham, UK). The
following results were obtained: TABLE-US-00004 Test
Compound*.sup.) EC.sub.50, pM Test Compound*.sup.) EC.sub.50, pM
GLP-1(7-37) 61 Example 31 96 Example 45 120 Example 30 41 Example
43 24 Example 26 8.8 Example 40 55 Example 25 99 Example 39 5.1
Example 19 79 Example 38 54 Example 16 3.5 Example 37 60 *.sup.)The
test compounds are the title compounds of the examples with the
numbers given.
Example 46
Synthesis of Arg.sup.26,34,Lys.sup.36
(N.sup.?-(?-glutamyl(N.sup.?-hexadecanoyl))) GLP-1(7-36)--OH
[1360] To a mixture of Arg.sup.26,34,Lys.sup.36GLP-1(7-36)--OH
(12.2 mg, 3.67 ?mol), EDPA (13.3 mg, 103 ?mol), NMP (1.71 ml) and
water (855 ?l) was added a solution of Pal-Glu(ONSu)-OBu.sup.t
(5.94 mg, 11 ?mol), prepared as described in PCT application no.
PCT/DK97/00340, in NMP (148 ?l). The reaction mixture was gently
shaken for 5 min. at room temperature, and then allowed to stand
for an additional 90 min. at room temperature. The reaction was
quenched by the addition of a solution of glycine (6 mg, 81 ?mol)
in water (0.6 ml). A 0.5% aqueous solution of ammonium-acetate (38
ml) was added, and the resulting mixture eluted onto a Varian 5 g
C8 Mega Bond Elut.RTM., the immobilised compound washed with 5%
aqueous acetonitril (20 ml), and finally liberated from the
cartridge by elution with TFA (25 ml). The eluate was concentrated
in vacuo, and the residue purified by column chromatography using a
cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA
system. The column was heated to 65?C and the acetonitril gradient
was 0-100% in 60 minutes. The title compound (3.1 mg, 23%) was
isolated, and the product was analysed by PDMS. The m/z value for
the protonated molecular ion was found to be 3695.+-.3. The
resulting molecular weight was thus 3694.+-.3 amu (theoretical
value 3694 amu).
Example 47
Synthesis of Arg.sup.26,34,Lys.sup.36
(N.sup.?-(?-glutamyl(N.sup.?-octadecanoyl))) GLP-1(7-36)--OH
[1361] To a mixture of Arg.sup.26,34,Lys.sup.36 GLP-1(7-36)--OH
(12.2 mg, 3.7 ?mol), EDPA (13.3 mg, 103 ?mol), NMP (1.71 ml) and
water (855 ?l) was added a solution of Ste-Glu(ONSu)-OBu.sup.t
(6.25 mg, 11 ?mol), prepared as described in PCT application no.
PCT/DK97/00340, in NMP (1 ml). The reaction mixture was gently
shaken for 5 min. at room temperature, and then allowed to stand
for an additional 90 min. at room temperature. The reaction was
quenched by the addition of a solution of glycine (6 mg, 81 ?mol)
in water (0.6 ml). A 0.5% aqueous solution of ammonium acetate (54
ml) was added, and the resulting mixture eluted onto a Varian 5 g
C8 Mega Bond Elut.RTM., the immobilised compound washed with 5%
aqueous acetonitril (20 ml), and finally liberated from the
cartridge by elution with TFA (25 ml). The eluate was concentrated
in vacuo, and the residue purified by column chromatography using a
cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA
system. The column was heated to 65?C and the acetonitril gradient
was 0-100% in 60 minutes. The title compound (3.7 mg, 27%) was
isolated, and the product was analysed by PDMS. The m/z value for
the protonated molecular ion was found to be 3723.+-.3. The
resulting molecular weight was thus 3722.+-.3 amu (theoretical
value 3722 amu).
Example 48
Synthesis of lithocholic acid 2,5-dioxopyrrolidin-1-yl ester
[1362] To a solution of lithocholic acid (5.44 g, 14.3 mmol) in a
mixture of anhydrous THF (120 ml) and anhydrous acetonitril (30 ml)
was added N-hydroxysuccinimide (1.78 g, 15 mmol). The mixture was
cooled to 10?C, a solution of DCC (3.44 g, 16.7 mmol) in anhydrous
THF (30 ml) was added drop wise, and the resulting reaction mixture
stirred for 16 h at room temperature. The reaction mixture was
filtered and partitioned between dichloromethane (450 ml) and 10%
aqueous Na.sub.2CO.sub.3 (150 ml). The phases were separated, and
the organic phase washed with 10% aqueous Na.sub.2CO.sub.3 (150
ml), water (2.times.150 ml), and dried (MgSO.sub.4). The solvent
was concentrated in vacuo. The residue was crystallised from a
mixture of dichloromethane (30 ml) and n-heptane (30 ml). The
precipitate was dried in a vacuum drying oven for 36 h to give the
title compound (3.46 g, 51%).
Example 49
Synthesis of Lit-Glu(ONSu)-OBu.sup.t
[1363] A suspension of H-Glu(OH)--OBu.sup.t (1.28 g, 6.33 mmol),
DMF (88 ml) and EDPA (0.82 g, 6.33 mmol) and lithocholic acid
2,5-dioxopyrrolidin-1-yl ester, prepared as described in example
48, was stirred for 16 h at room temperature. The reaction mixture
was concentrated in vacuo and the residue dissolved in ethyl
acetate (40 ml). The resulting solution was washed with 5% aqueous
citric acid (2.times.25 ml), brine (10 ml), and filtered). The
solvent was concentrated in vacuo and the residue dissolved in DMF
(12 ml). The resulting solution was added drop wise to a 10%
aqueous solution of citric acid whereby the product precipitates.
The precipitate was collected and washed with iced water, and dried
in vacuo. The crude product was recrystallised from a mixture of
n-heptane (40 ml) and 2-propanol (17 ml). The precipitate was dried
in a vacuum drying oven for 4 h to give the free acid
intermediate.
[1364] To a solution of the free acid intermediate in DMF (18 ml)
was added hydroxysuccinimide (0.45 g, 3.91 mmol), followed by a
solution of DCC (0.73 g, 3.56 mmol) in dichloromethane (18 ml). The
resulting mixture was stirred at ambient temperature for 18 h, and
then filtered. The filtrate was concentrated in vacuo to a solid,
and the residue was dissolved in dichloromethane (25 ml), and the
filtration repeated, the solvent removed in vacuo to give a foam.
The residue was dissolved in refluxing n-heptane (35 ml), and the
product crystallised b addition of 2-propanol. The precipitate was
collected, washed with cold n-heptane, dried at 35?C in vacuo to
give the title compound (1.34 g, 57%).
Example 50
Synthesis of
Arg.sup.34,Lys.sup.26(N.sup.?-(?-glutamyl(N.sup.?-lithochoyl)))
GLP-1(7-37)--OH
[1365] To a mixture of Arg.sup.34,Lys.sup.26 GLP-1(7-37)--OH (41.1
mg, 12.2 ?mol), EDPA (44 mg, 340 ?mol), NMP (5.76 ml) and water
(2.88 ml) was added a solution of Lit-Glu(ONSu)-OBu.sup.t (24 mg,
37 ?mol), prepared as described in example 49, in NMP (600 ?l). The
reaction mixture was gently shaken for 5 min. at room temperature,
and then allowed to stand for an additional 75 min. at room
temperature. The reaction was quenched by the addition of a
solution of glycine (20 mg, 268 ?mol) in water (2 ml). A 0.5%
aqueous solution of ammonium acetate (128 ml) was added, and the
resulting mixture divided into two equal portions, and each portion
eluted onto a Varian 5 g C8 Mega Bond Elut.RTM., the immobilised
compound washed with 5% aqueous acetonitril (2.times.25 ml), and
finally liberated from the cartridge by elution with TFA
(2.times.25 ml). The combined eluates were concentrated in vacuo,
and the residue purified by column chromato-graphy using a
cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA
system. The column was heated to 65?C and the acetonitril gradient
was 0-100% in 60 minutes. The title compound (5 mg, 11%) was
isolated, and the product was analysed by PDMS. The m/z value for
the protonated molecular ion was found to be 3872.+-.3. The
resulting molecular weight was thus 3871.+-.3 amu (theoretical
value 3871 amu).
Example 51
Synthesis of Arg.sup.26 Lys.sup.34
(N.sup.?-(?-glutamyl(N.sup.?-hexadecanoyl))) GLP-1(7-37)--OH
[1366] To a mixture of Arg.sup.26,Lys.sup.34 GLP-1(7-37)--OH (18
mg, 5.3 ?mol), EDPA (19.3 mg, 149 ?mol), NMP (2.52 ml) and water
(1.26 ml) was added a solution of Pal-Glu(ONSu)-OBu.sup.t (8.6 mg,
16 ?mol) in NMP (215 ?l). The reaction mixture was gently shaken
for 5 min. at room temperature, and then allowed to stand for an
additional 90 min. at room temperature. The reaction was quenched
by the addition of a solution of glycine (8.8 mg, 117 ?mol) in
water (0.88 ml). A 0.5% aqueous solution of ammonium acetate (50
ml) was added, and the resulting mixture eluted onto a Varian 5 g
C8 Mega Bond Elut.RTM., the immobilised compound washed with 5%
aqueous acetonitril (25 ml), and finally liberated from the
cartridge by elution with TFA (25 ml). The eluate was concentrated
in vacuo, and the residue purified by column chromatography using a
cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA
system. The column was heated to 65?C and the acetonitril gradient
was 0-100% in 60 minutes. The title compound (6 mg, 30%) was
isolated, and the product was analysed by PDMS. The m/z value for
the protonated molecular ion was found to be 3752.+-.3. The
resulting molecular weight was thus 3751.+-.3 amu (theoretical
value 3751 amu).
Example 52
Synthesis of
desamino-His.sup.7,Arg.sup.26,Lys.sup.34(N.sup.?-(?-glutamyl(N.sup.?-hexa-
decanoyl))) GLP-1(7-37)--OH
[1367] To a mixture of desamino-His.sup.7,Arg.sup.26,Lys.sup.34
GLP-1(7-37)--OH (14.3 mg, 4.2 ?mol), EDPA (15.3 mg, 119 ?mol), NMP
(2 ml) and water (1 ml) was added a solution of
Pal-Glu(ONSu)-OBu.sup.t (6.84 mg, 12.7 ?mol) in NMP (171 ?l). The
reaction mixture was gently shaken for 5 min. at room temperature,
and then allowed to stand for an additional 50 min. at room
temperature. The reaction was quenched by the addition of a
solution of glycine (7 mg, 99 ?mol) in water (700 ?l). A 0.5%
aqueous solution of ammonium acetate (42 ml) was added, and the
resulting mixture eluted onto a Varian 5 g C8 Mega Bond Elut.RTM.,
the immobilised compound washed with 5% aqueous acetonitril (25
ml), and finally liberated from the cartridge by elution with TFA
(25 ml). The eluate was concentrated in vacuo, and the residue
purified by column chromatography using a cyanopropyl column
(Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column
was heated to 65?C and the acetonitril gradient was 0-100% in 60
minutes. The title compound (5.6 mg, 35%) was isolated, and the
product was analysed by PDMS. The m/z value for the protonated
molecular ion was found to be 3738.+-.3. The resulting molecular
weight was thus 3737.+-.3 amu (theoretical value 3737 amu).
Example 53
Synthesis of Gly.sup.8, Arg.sup.26,34,Lys38
(N.sup.?-(?-glutamyl(N.sup.?-hexadecanoyl))) GLP-1(7-38)--OH
[1368] To a mixture of Gly.sup.8,Arg.sup.26,34,Lys.sup.38
GLP-1(7-38)--OH (11.8 mg, 3.4 ?mol), EDPA (12.1 mg, 94 ?mol), NMP
(1.65 ml) and water (0.83 ml) was added a solution of
Pal-Glu(ONSu)-OBu.sup.t (5.4 mg, 10 ?mol) in NMP (135 ?l). The
reaction mixture was gently shaken for 5 min. at room temperature,
and then allowed to stand for an additional 75 min. at room
temperature. The reaction was quenched by the addition of a
solution of glycine (5.5 mg, 73.7 ?mol) in water (553 ?l). A 0.5%
aqueous solution of ammonium acetate (36 ml) was added, and the
resulting mixture eluted onto a Varian 5 g C8 Mega Bond Elut.RTM.,
the immobilised compound washed with 5% aqueous acetonitril (25
ml), and finally liberated from the cartridge by elution with TFA
(25 ml). The eluate was concentrated in vacuo, and the residue
purified by column chromatography using a cyanopropyl column
(Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column
was heated to 65?C and the acetonitril gradient was 0-100% in 60
minutes. The title compound (5 mg, 38%) was isolated, and the
product was analysed by PDMS. The m/z value for the protonated
molecular ion was found to be 3895.+-.3. The resulting molecular
weight was thus 3894.+-.3 amu (theoretical value 3894 amu).
Example 54
Synthesis of Gly.sup.8,Glu.sup.37,Arg.sup.26,34,Lys.sup.38
(N.sup.?-(?-glutamyl(N.sup.?-hexadecanoyl))) GLP-1(7-38)--OH
[1369] To a mixture of
Gly.sup.8,Glu.sup.37,Arg.sup.26,34,Lys.sup.38 GLP-1(7-38)--OH (9
mg, 2.48 ?mol), EDPA (9 mg, 69.4 ?mol), NMP (1.25 ml) and water
(0.63 ml) was added a solution of Pal-Glu(ONSu)-OBu.sup.t (4 mg,
7.4 ?mol) in NMP (100 ?l). The reaction mixture was gently shaken
for 5 min. at room temperature, and then allowed to stand for an
additional 105 min. at room temperature. The reaction was quenched
by the addition of a solution of glycine (4.1 mg, 54.6 ?mol) in
water (410 ?l). A 0.5% aqueous solution of ammonium acetate (27 ml)
was added, and the resulting mixture eluted onto a Varian 5 g C8
Mega Bond Elut.RTM., the immobilised compound washed with 5%
aqueous acetonitril (15 ml), and finally liberated from the
cartridge by elution with TFA (15 ml). The eluate was concentrated
in vacuo, and the residue purified by column chromatography using a
cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA
system. The column was heated to 65?C and the acetonitril gradient
was 0-100% in 60 minutes. The title compound (2.9 mg, 29%) was
isolated, and the product was analysed by PDMS. The m/z value for
the protonated molecular ion was found to be 3967.+-.3. The
resulting molecular weight was thus 3966.+-.3 amu (theoretical
value 3967 amu).
Example 55
Synthesis of
Gly.sup.8,Glu.sup.37,Arg.sup.26,34,Lys.sup.38(N.sup.?-(?-glutamyl(N.sup.?-
-octadecanoyl))) GLP-1(7-38)--OH
[1370] To a mixture of
Gly.sup.8,Glu.sup.37,Arg.sup.26,34,Lys.sup.38 GLP-1(7-38)--OH (9
mg, 2.5 ?mol), EDPA (9 mg, 69.4 ?mol), NMP (1.25 ml) and water
(0.63 ml) was added a solution of Ste-Glu(ONSu)-OBu.sup.t (4.2 mg,
7.4 ?mol in NMP (105 ?l). The reaction mixture was gently shaken
for 5 min. at room temperature, and then allowed to stand for an
additional 105 min. at room temperature. The reaction was quenched
by the addition of a solution of glycine (4.1 mg, 54.6 ?mol) in
water (409 ?l). A 0.5% aqueous solution of ammonium acetate (27 ml)
was added, and the resulting mixture eluted onto a Varian 5 g C8
Mega Bond Elut.RTM., the immobilised compound washed with 5%
aqueous acetonitril (15 ml), and finally liberated from the
cartridge by elution with TFA (15 ml). The eluate was concentrated
in vacuo, and the residue purified by column chromatography using a
cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA
system. The column was heated to 65?C and the acetonitril gradient
was 0-100% in 60 minutes. The title compound (3.2 mg, 32%) was
isolated, and the product was analysed by PDMS. The m/z value for
the protonated molecular ion was found to be 3995.+-.3. The
resulting molecular weight was thus 3994.+-.3 amu (theoretical
value 3995 amu).
Example 56
Synthesis of Cap-Glu(ONSu)-OBu.sup.t
[1371] To a solution of octanoic acid (5 g, 34.7 mmol) and
N-hydroxysuccinimide (4 g, 34.7 mmol) in anhydrous acetonitril (10
ml) was added a solution of DCC (7.15 g, 34.7 mmol) in anhydrous
dichloromethane (15 ml), and the resulting reaction mixture stirred
for 16 h at room temperature. The precipitated solid was filtered
off and recrystallised from a mixture of n-heptane (40 ml) and
2-propanol (2 ml). The precipitate was dried in a vacuum drying
oven for 16 h to give the intermediate Cap-ONSu. A suspension of
the crude ester intermediate (3.9 g, 16.2 mmol),
(L)-H-Glu(OH)--OBu.sup.t (3.28 g, 16.2 mmol), DMF (268 ml) and EDPA
(2.1 g, 16.2 mmol) was stirred for 64 h at room temperature. The
reaction mixture was concentrated in vacuo and the residue
dissolved in ethyl acetate (50 ml). The resulting solution was
washed with 5% aqueous citric acid (2.times.25 ml). The solvent was
concentrated in vacuo and the residue dissolved in DMF (36 ml). The
resulting solution was added drop wise to a 10% aqueous solution of
citric acid (357 ml) and extracted with ethyl acetate (200 ml), and
dried (MgSO.sub.4). The solvent was concentrated in vacuo to give
the crude glutamic acid intermediate. To a mixture of the crude
glutamic acid intermediate, N-hydroxysuccinimide (1.85 g, 16.1
mmol) and DMF (25 ml) was added a solution of DCC (3.32 g, 16.1
mmol) in dichloromethane (15 ml). The resulting mixture was stirred
at ambient temperature for 20 h. The reaction mixture was filtered
and the solvent concentrated in vacuo. The residue was purified on
a silica gel column (40-63 ?), eluted with a mixture of
dichloromethane and acetonitril (1:1) to give the title compound
(0.63 g, 6% over all).
Example 57
Synthesis of
desamino-His.sup.7,Arg.sup.26,Lys.sup.34(N.sup.?-(?-glutamyl(N.sup.?-octa-
noyl))) GLP-1(7-37)--OH
[1372] To a mixture of desamino-His.sup.7,Arg.sup.26,Lys.sup.34
GLP-1(7-37)--OH (14.3 mg, 4.2 ?mol), EDPA (15.3 mg, 119 ?mol), NMP
(2 ml) and water (1 ml) was added a solution of
Cap-Glu(ONSu)-OBu.sup.t (6.8 mg, 12.7 ?mol), prepared as described
in example 56, in NMP (135 ?l). The reaction mixture was gently
shaken for 5 min. at room temperature, and then allowed to stand
for an additional 2 h at room temperature. The reaction was
quenched by the addition of a solution of glycine (7 mg, 93 ?mol)
in water (698 ?l). A 0.5% aqueous solution of ammonium acetate (42
ml) was added, and the resulting mixture eluted onto a Varian 5 g
C8 Mega Bond Elut.RTM., the immobilised compound washed with 5%
aqueous acetonitril (25 ml), and finally liberated from the
cartridge by elution with TFA (25 ml). The eluate was concentrated
in vacuo, and the residue purified by column chromatography using a
cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA
system. The column was heated to 65?C and the acetonitril gradient
was 0-100% in 60 minutes. The title compound (4.1 mg, 27%) was
isolated, and the product was analysed by PDMS. The m/Z value for
the protonated molecular ion was found to be 3626.+-.3. The
resulting molecular weight was thus 3625.+-.3 amu (theoretical
value 3625 amu).
Example 58
Synthesis of
Glu.sup.37,Arg.sup.26,34,Lys.sup.38N.sup.?-(?-glutamyl(N.sup.?-hexadecano-
yl))) GLP-1(7-38)--OH
[1373] To a mixture of Glu.sup.37,Arg.sup.26,34,Lys.sup.38
GLP-1(7-38)--OH (17.6 mg, 4.9 ?mol), EDPA (17.6 mg, 136 ?mol), NMP
(1.23 ml) and water (2.46 ml) was added a solution of
Pal-Glu(ONSu)-OBu.sup.t (7.9 mg, 14.6 ?mol) in NMP (197 ?l). The
reaction mixture was gently shaken for 5 min. at room temperature,
and then allowed to stand for an additional 2 h at room
temperature. The reaction was quenched by the addition of a
solution of glycine (8 mg, 107 ?mol) in water (804 ?l). A 0.5%
aqueous solution of ammonium acetate (49 ml) was added, and the
resulting mixture eluted onto a Varian 5 g C8 Mega Bond Elut.RTM.,
the immobilised compound washed with 5% aqueous acetonitril (25
ml), and finally liberated from the cartridge by elution with TFA
(25 ml). The eluate was concentrated in vacuo, and the residue
purified by column chromatography using a cyanopropyl column
(Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column
was heated to 65?C and the acetonitril gradient was 0-100% in 60
minutes. The title compound (5.1 mg, 26%) was isolated, and the
product was analysed by PDMS. The m/z value for the protonated
molecular ion was found to be 3981.+-.3. The resulting molecular
weight was thus 3980.+-.3 amu (theoretical value 3981 amu).
Example 59
Synthesis of Arg.sup.34,Lys.sup.26
(N.sup.?-(?-glutamyl(N.sup.?-octadecanoyl))) GLP-1(7-37)--OH
[1374] To a mixture of Arg.sup.34 GLP-1(7-37)--OH (41.1 mg, 12.2
?mol), EDPA (44 mg, 341 ?mol), NMP (5.76 ml) and water (2.88 ml)
was added a solution of Ste-Glu(ONSu)-OBu.sup.t (20.7 mg, 36.5 ?mol
in NMP (517 ?l). The reaction mixture was gently shaken for 5 min.
at room temperature, and then allowed to stand for an additional 2
h at room temperature. The reaction was quenched by the addition of
a solution of glycine (20.1 mg, 268 ?mol) in water (2.01 ml). A
0.5% aqueous solution of ammonium-acetate (120 ml) was added, and
the resulting mixture eluted onto a Varian 5 g C8 Mega Bond
Elut.RTM., the immobilised compound washed with 5% aqueous
acetonitril (25 ml), and finally liberated from the cartridge by
elution with TFA (25 ml). The eluate was concentrated in vacuo, and
the residue purified by column chromatography using a cyanopropyl
column (Zorbax 300SB-CN) and a standard acetonitril/TFA system. The
column was heated to 65?C and the acetonitril gradient was 0-100%
in 60 minutes. The title compound (15.4 mg, 34%) was isolated, and
the product was analysed by PDMS. The m/z value for the protonated
molecular ion was found to be 3781.+-.3. The resulting molecular
weight was thus 3780.+-.3 amu (theoretical value 3779 amu).
Example 60
Synthesis of Arg.sup.34,Lys.sup.26(N.sup.?-decanoyl)
GLP-1(7-37)
[1375] To a mixture of Arg.sup.34-GLP-1(7-37)--OH (20 mg, 5.9
?mol), EDPA (21.4 mg, 165 ?mol), NMP (2.8 ml) and water (1.4 ml)
was added a solution of Cac-ONSu (4.8 mg, 17.7 ?mol) in NMP (119
?l). The reaction mixture was gently shaken for 5 min., and then
allowed to stand for an additional 2 h at room temperature. The
reaction was quenched by the addition of a solution of glycine (9.8
mg, 130 ?mol) in water (98 ?l). The resulting mixture was purified
by column chromatography using a cyanopropyl column (Zorbax
300SB-CN) and a standard acetonitril/TFA system. The column was
heated to 65?C and the acetonitril gradient was 0-100% in 60
minutes. The title compound (7.4 mg, 35%) was isolated, and the
product was analysed by PDMS. The m/z value for the protonated
molecular ion was found to be 3539.6.+-.3. The resulting molecular
weight was thus 3538.6.+-.3 amu (theoretical value 3538 amu).
Example 61
Synthesis of Arg.sup.34,Lys.sup.26 (N.sup.?-(hexadecanoyl))
GLP-1(7-37)--OH
[1376] To a mixture of Arg.sup.34 GLP-1(7-37)--OH (41.1 mg, 12.2
?mol), EDPA (44 mg, 340 ?mol), NMP (2.88 ml) and water (2.88 ml)
was added a solution of Pal-ONSu (12.9 mg, 36.5 ?mol) in NMP (3.3
ml). The reaction mixture was gently shaken for 5 min. at room
temperature, and then allowed to stand for an additional 110 min.
at room temperature. The reaction was quenched by the addition of a
solution of glycine (20.1 mg, 268 ?mol) in water (201 ?l). The
solvent was concentrated in vacuo, and the residue purified by
column chromatography using a cyanopropyl column (Zorbax 300SB-CN)
and a standard acetonitril/TFA system. The column was heated to
65?C and the acetonitril gradient was 0-100% in 60 minutes. The
title compound (15 mg, 34%) was isolated, and the product was
analysed by PDMS.
Example 62
Synthesis of Arg.sup.26,34Lys.sup.27
(N.sup.?-(?-glutamyl(N.sup.?-hexadecanoyl))) GLP-1(7-37)--OH
[1377] To a mixture of Arg.sup.26,34,Lys.sup.27 GLP-1(7-37)--OH
(11.6 mg, 3.4 ?mol), EDPA (12.3 mg, 94.9 ?mol), NMP (1.6 ml) and
water (0.8 ml) was added a solution of Pal-Glu(ONSu)-OBu.sup.t (5.5
mg, 10.2 ?mol) in NMP (137 ?l). The reaction mixture was gently
shaken for 5 min. at room temperature, and then allowed to stand
for an additional 90 min. at room temperature. The reaction was
quenched by the addition of a solution of glycine (5.6 mg, 74.6
?mol) in water (560 ?l). A 0.5% aqueous solution of ammonium
acetate (34 ml) was added, and the resulting mixture eluted onto a
Varian 5 g C8 Mega Bond Elut.RTM., the immobilised compound washed
with 5% aqueous acetonitril (15 ml), and finally liberated from the
cartridge by elution with TFA (25 ml). The solvent was concentrated
in vacuo, and the residue purified by column chromatography using a
cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA
system. The column was heated to 65?C and the acetonitril gradient
was 0-100% in 60 minutes. The title compound (2.1 mg, 16%) was
isolated, and the product was analysed by PDMS.
Example 63
Synthesis of
Arg.sup.26,34,Lys.sup.23(N.sup.?-(?-glutamyl(N.sup.?-hexadecanoyl)))
GLP-1(7-37)--OH
[1378] To a mixture of Arg.sup.26,34Lys.sup.23GLP-1 (7-37)--OH
(11.6 mg, 3.4 ?mol), EDPA (12.3 mg, 94.9 ?mol), NMP (1.6 ml) and
water (0.8 ml) was added a solution of Pal-Glu(ONSu)-OBu.sup.t (5.5
mg, 10.2 ?mol) in NMP (137 ?l). The reaction mixture was gently
shaken for 5 min. at room temperature, and then allowed to stand
for an additional 90 min. at room temperature. The reaction was
quenched by the addition of a solution of glycine (5.6 mg, 74.6
?mol) in water (560 ?l). A 0.5% aqueous solution of ammonium
acetate (34 ml) was added, and the resulting mixture eluted onto a
Varian 5 g C8 Mega Bond Elut.RTM., the immobilised compound washed
with 5% aqueous acetonitril (15 ml), and finally liberated from the
cartridge by elution with TFA (25 ml). The solvent was concentrated
in vacuo, and the residue purified by column chromatography using a
cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA
system. The column was heated to 65?C and the acetonitril gradient
was 0-100% in 60 minutes. The title compound (3.1 mg, 24%) was
isolated, and the product was analysed by PDMS.
Example 64
Synthesis of
Arg.sup.26,34,Lys.sup.18(N.sup.?-(?-glutamyl(N.sup.?-hexadecanoyl)))
GLP-1(7-37)--OH
[1379] To a mixture of Arg.sup.26,34, Lys.sup.18 GLP-1(7-37)--OH
(11.7 mg, 3.4 ?mol), EDPA (12.2 mg, 94.6 ?mol), NMP (1.6 ml) and
water (0.8 ml) was added a solution of Pal-Glu(ONSu)-OBu.sup.t (5.5
mg, 10.2 ?mol) in NMP (137 ?l). The reaction mixture was gently
shaken for 5 min. at room temperature, and then allowed to stand
for an additional 90 min. at room temperature. The reaction was
quenched by the addition of a solution of glycine (5.6 mg, 74.6
?mol) in water (560 ?l). A 0.5% aqueous solution of ammonium
acetate (34 ml) was added, and the resulting mixture eluted onto a
Varian 5 g C8 Mega Bond Elut.RTM., the immobilised compound washed
with 5% aqueous acetonitril (25 ml), and finally liberated from the
cartridge by elution with TFA (25 ml). The solvent was concentrated
in vacuo, and the residue purified by column chromatography using a
cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA
system. The column was heated to 65?C and the acetonitril gradient
was 0-100% in 60 minutes. The title compound (1.9 mg, 15%) was
isolated, and the product was analysed by PDMS.
Example 65
Synthesis of Arg.sup.34,Lys.sup.26 (N.sup.?-(octanoyl))
GLP-1(7-37)--OH
[1380] To a mixture of Arg.sup.34 GLP-1(7-37)--OH (41.1 mg, 12.2
?mol), EDPA (44 mg, 341 ?mol), NMP (5.76 ml) and water (2.88 ml)
was added a solution of Cap-ONSu (8.8 mg, 36.5 ?mol), prepared as
described in example 56, in NMP (106 ?l). The reaction mixture was
gently shaken for 5 min. at room temperature, and then allowed to
stand for an additional 115 min. at room temperature. The reaction
was quenched by the addition of a solution of glycine (20 mg, 268
?mol) in water (200 ?l). The solvent was concentrated in vacuo, and
the residue purified by column chromatography using a cyanopropyl
column (Zorbax 300SB-CN) and a standard acetonitril/TFA system. The
column was heated to 65?C and the acetonitril gradient was 0-100%
in 60 minutes. The title compound (18.8 mg, 44%) was isolated, and
the product was analysed by PDMS.
Example 66
Synthesis of Arg.sup.34,Lys.sup.26 (N.sup.?-(dodecanoyl))
GLP-1(7-37)--OH
[1381] To a mixture of Arg.sup.34 GLP-1(7-37)--OH (41.1 mg, 12.2
?mol), EDPA (44 mg, 341 ?mol), NMP (5.76 ml) and water (2.88 ml)
was added a solution of Lau-ONSu (8.8 mg, 36.5 ?mol), prepared in a
similar manner as described for Cap-ONSu in example 56), in NMP
(271 ?l). The reaction mixture was gently shaken for 5 min. at room
temperature, and then allowed to stand for an additional 100 min.
at room temperature. The reaction was quenched by the addition of a
solution of glycine (20.1 mg, 268 ?mol) in water (200 ?l). The
solvent was concentrated in vacuo, and the residue purified by
column chromatography using a cyanopropyl column (Zorbax 300SB-CN)
and a standard acetonitril/TFA system. The column was heated to
65?C and the acetonitril gradient was 0-100% in 60 minutes. The
title compound (18 mg, 42%) was isolated, and the product was
analysed by PDMS.
Example 67
Synthesis of Pal-GABA-ONSu
[1382] A mixture of Pal-ONSu (3 g, 8.48 mmol), ?-aminobutyric acid
(0.87 g, 8.48 mmol) in DMF (200 ml) was stirred at room temperature
for 60 h. The reaction mixture was filtered and the filtrate was
added drop wise to 10% aqueous citric acid (500 ml). The
precipitated N-acylated intermediate was collected and dried in
vacuo. To a suspension of the dried intermediate in DMF (35 ml) was
added a solution of DCC (1.45 g, 7.0 mmol) in dichloromethane (20
ml). The resulting mixture was stirred at room temperature for 20
h, and then filtered. The solvent was removed in vacuo to give a
solid residue. The residue was recrystallised from a mixture of
n-heptane (50 ml) and 2-propanol (2.5 ml) to give the title
compound (2.5 g, 75%).
Example 68
Synthesis of Arg.sup.34,Lys.sup.26
(N.sup.?-(?-aminobutyroyl(N.sup.?-hexadecanoyl)))
GLP-1(7-37)--OH
[1383] To a mixture of Arg.sup.34, Lys.sup.26 GLP-1(7-37)--OH (41.1
mg, 12.2 ?mol), EDPA (44 mg, 341 ?mol), NMP (5.76 ml) and water
(2.88 ml) was added a solution of Pal-GABA-ONSu (16 mg, 36.5 ?mol),
prepared as described in example 67) in NMP (400 ?l). The reaction
mixture was gently shaken for 5 min. at room temperature, and then
allowed to stand for an additional 100 min. at room temperature.
The reaction was quenched by the addition of a solution of glycine
(20 mg, 268 ?mol) in water (200 ?l). The solvent was concentrated
in vacuo, and the residue purified by column chromatography using a
cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA
system. The column was heated to 65?C and the acetonitril gradient
was 0-100% in 60 minutes.
[1384] The title compound (15.8 mg, 35%) was isolated, and the
product was analysed by PDMS.
Example 69
Synthesis of N.sup.?-hexadecanoyl-D-glutamic acid ?-t-butyl
ester-?-2,5-dioxopyrrolidin-1-yl ester
[1385] A mixture of Pal-ONSu (6.64 g, 18.8 mmol), D-glutamic acid
?-tert-butyl ester (4.5 g, 18.8 mmol) and EDPA (4.85 g, 37.5 mmol)
in DMF (538 ml) was stirred at room temperature for 60 h. The
solvent was removed and the residue dissolved in ethyl acetate (175
ml). The resulting solution was extracted with 10% aqueous citric
acid (2.times.125 ml), and the organic phase concentrated in vacuo.
The residue was dissolved in DMF (60 ml), and the resulting mixture
slowly added to 10% aqueous citric acid (500 ml). The precipitated
compound was collected and dried in vacuo, to give the crude
N-acylated glutamic acid intermediate. The crude intermediate was
dissolved in DMF (35 ml), and a solution of DCC (3.5 g, 17 mmol) in
dichloromethane (70 ml) was added. The resulting mixture was
stirred at room temperature for 20 h, and then filtered. The
filtrate was concentrated in vacuo, and the solid residue
recrystallised from a mixture of n-heptane (75 ml) and 2-propanol
(5 ml), to give the title compound (5.2 g, 50%)
Example 70
Synthesis of Arg.sup.34,Lys.sup.26
(N.sup.?-(?-D-glutamyl(N.sup.?-hexadecanoyl))) GLP-1(7-37)--OH
[1386] To a mixture of Arg.sup.34, Lys.sup.26 GLP-1(7-37)--OH (41.1
mg, 12.2 ?mol), EDPA (44 mg, 341 ?mol), NMP (5.76 ml) and water
(2.88 ml) was added a solution of N.sup.?-hexadecanoyl-D-glutamic
acid ?-t-butyl ester-?-2,5-dioxopyrrolidin-1-yl ester (19.7 mg,
36.5 ?mol) in NMP (491 ?1). The reaction mixture was gently shaken
for 5 min. at room temperature, and then allowed to stand for an
additional 95 min. at room temperature. The reaction was quenched
by the addition of a solution of glycine (20 mg, 268 ?mol) in water
(2 ml). A 0.5% aqueous solution of ammonium acetate (120 ml) was
added, and the resulting mixture divided into to equal portions,
and each portion eluted onto a Varian 5 g C8 Mega Bond Elut.RTM.,
the immobilised compound washed with 5% aqueous acetonitril (25
ml), and finally liberated from the cartridge by elution with TFA
(25 ml). The combined eluates were concentrated in vacuo, and the
residue purified by column chromatography using a cyanopropyl
column (Zorbax 300SB-CN) and a standard acetonitril/TFA system. The
column was heated to 65?C and the acetonitril gradient was 0-100%
in 60 minutes. The title compound (10.5 mg, 23%) was isolated, and
the product was analysed by PDMS.
Example 71
Synthesis of Lys.sup.34
(N.sup.?-(?-glutamyl(N.sup.?-tetradecanoyl))) GLP-1(7-37)
[1387] To a mixture of GLP-1(7-37)--OH (33.6 mg, 8.9 ?mol), EDPA
(32.4 mg, 250 ?mol), NMP (2.1 ml) and water (2.1 ml) was added a
solution of Myr-Glu(ONSu)-OBu.sup.t (9.1 mg, 17.9 ?mol), prepared
as described above, in NMP (228 ?l). The reaction mixture was
gently shaken for 5 min., and then allowed to stand for an
additional 80 min. at room temperature. The reaction was quenched
by the addition of a solution of glycine (14.8 mg, 197 ?mol) in
water (1.47 ml). A 0.5% aqueous solution of ammonium acetate (100
ml) was added, and the resulting mixture divided into two equal
portions, and each portion eluted onto a Varian 5 g C8 Mega Bond
Elut.RTM., the immobilised compound washed with 5% aqueous
acetonitril (2.times.25 ml), and finally liberated from the
cartridge by elution with TFA (2.times.25 ml). The combined eluates
were concentrated in vacuo, and the residue purified by column
chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a
standard acetonitril/TFA system. The column was heated to 65?C and
the acetonitril gradient was 0-100% in 60 minutes. The title
compound (0.19 mg, 0.6%) was isolated, and the product was analysed
by PDMS. The m/z value for the protonated molecular ion was found
to be 3693.+-.3. The resulting molecular weight was thus 3692.+-.3
amu (theoretical value 3695 amu).
Example 72
Synthesis of
Arg.sup.26,34,Lys.sup.8(N.sup.?-(?-glutamyl(N.sup.?-hexadecanoyl)))
GLP-1(7-37)
[1388] To a mixture of Arg.sup.26,34, Lys.sup.8-GLP-1(7-37)--OH
(10.3 mg, 3 ?mol), EDPA (10.8 mg, 83 ?mol), NMP (1.44 ml) and water
(0.72 ml) was added a solution of Pal-Glu(ONSu)-OBu.sup.t (4.8 mg,
8.9 ?mol), prepared as described above, in NMP (120 ?l). The
reaction mixture was gently shaken for 5 min., and then allowed to
stand for an additional 70 min. at room temperature. The reaction
was quenched by the addition of a solution of glycine (4.9 mg, 65.3
?mol) in water (490 ?l). A 0.5% aqueous solution of ammonium
acetate (30 ml) was added, and the resulting mixture eluted onto a
Varian 5 g C8 Mega Bond Elut.RTM., the immobilised compound washed
with 5% aqueous acetonitril (25 ml), and finally liberated from the
cartridge by elution with TFA (25 ml). The eluate was concentrated
in vacuo, and the residue purified by column chromatography using a
cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA
system. The column was heated to 65?C and the acetonitril gradient
was 0-100% in 60 minutes. The title compound (3.2 mg, 28%) was
isolated, and the product was analysed by PDMS. The m/z value for
the protonated molecular ion was found to be 3836.+-.3. The
resulting molecular weight was thus 3835.+-.3 AMU (theoretical
value 3836 AMU).
Example 73
Synthesis of Lau-Glu(ONSu)-OBu.sup.t
[1389] To a solution of H-Glu-OBu.sup.t (3 g, 15 mmol) in DMF (344
ml) was added EDPA (2.58 ml, 15 mmol) and a solution of Lau-ONSu
(4.5 g, 15 mmol), prepared in a similar manner as described for
Cap-ONSu in example 56, in DMF (74 ml). The resulting mixture was
stirred at ambient temperature for 18 h, and the solvent removed in
vacuo. The oily residue was partitioned between ethyl acetate (150
ml) and 5% aqueous citric acid (250 ml). The organic phase was
concentrated in vacuo. The residue was dissolved in DMF (40 ml) and
the solution added drop by drop to a 10% aqueous citric acid
solution (350 ml). The precipitated product was collected, washed
with water and dried in vacuo for 18 h to give the intermediate
free acid. To solution of the free acid intermediate in DMF (25 ml)
was added N-hydroxysuccinimide (1.7 g, 14.8 mmol) and a solution of
N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide (2.58 g, 13.5 mmol)
in dichloromethane (52 ml). The resulting mixture was stirred at
room temperature for 18 h, and the solvents removed in vacuo. The
oily residue was partitioned between dichloromethane (80 ml) and
water (80 ml). The organic phase was washed with 5% aqueous citric
acid, dried (MgSO.sub.4), and concentrated in vacuo to a solid. The
solid residue was crystallised from a mixture of n-heptane (77 ml)
and 2-propanol (50 ml), and finally recrystallised from n-heptane
(76 ml) to give the title compound (2.96 g, 46%).
Example 74
Synthesis of
Arg.sup.34,Lys.sup.26(N.sup.?-(?-glutamyl(N.sup.?-dodecanoyl)))
GLP-1(7-37)
[1390] To a mixture of Arg.sup.34-GLP-1(7-37)--OH (20.6 mg, 6.1
?mol), EDPA (22 mg, 171 ?mol), NMP (2.88 ml) and water (1.44 ml)
was added a solution Lau-Glu(ONSu)-OBu.sup.t (10.2 mg, 21.2 ?mol),
prepared as described in example 73, in NMP (255 ?l). The reaction
mixture was gently shaken for 5 min., and then allowed to stand for
an additional 75 min. at room temperature. The reaction was
quenched by the addition of a solution of glycine (10 mg, 134 ?mol)
in water (100 ?l). A 0.5% aqueous solution of ammonium acetate (61
ml) was added, and the resulting mixture eluted onto a Varian 5 g
C8 Mega Bond Elut.RTM., the immobilised compound washed with 5%
aqueous acetonitril (25 ml), and finally liberated from the
cartridge by elution with TFA (25 ml). The eluate was concentrated
in vacuo, and the residue purified by column chromatography using a
cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA
system. The column was heated to 65?C and the acetonitril gradient
was 0-100% in 60 minutes. The title compound (8.2 mg, 36%) was
isolated, and the product was analysed by PDMS. The m/z value for
the protonated molecular ion was found to be 3693.+-.3. The
resulting molecular weight is 3692.+-.3 AMU (theoretical value 3693
AMU).
Example 75
Synthesis of Lau-?-Ala-ONSu
[1391] To a solution of Lau-ONSu (4.25 g, 14.3 mmol), prepared in a
similar manner to in DMF (400 ml) was added EDPA (1.84 g, 14.3
mmol) and ?-alanine (1.27 g, 14.3 mmol). The resulting mixture was
stirred at ambient temperature for 18 h. Water (250 ml) and DMF (50
ml) were added and the solution stirred for 1 h at room
temperature. The solvents were removed in vacuo to give a solid.
The solid residue was dissolved in DMF (50 ml) and the solution
added drop by drop to a 5% aqueous solution of citric acid (200
ml). The precipitate collected, washed with water (50 ml) and dried
in vacuo to give the title compound (3.6 g, 93%).
Example 76
Synthesis of Pal-?-Ala-ONSu
[1392] To a solution of Pal-ONSu (4.25 g, 14.3 mmol) in DMF (400
ml) was added EDPA (1.84 g, 14.3 mmol) and ?-alanine (1.27 g, 14.3
mmol). The resulting mixture was stirred at ambient temperature for
18 h. Water (250 ml) and DMF (50 ml) were added and the solution
stirred for 1 h at room temperature. The solvents were removed in
vacuo to give a solid. The solid residue was dissolved in DMF (50
ml) and the solution added drop by drop to a 5% aqueous solution of
citric acid (200 ml). The precipitate collected, washed with water
(50 ml) and dried in vacuo to give the title compound (3.6 g,
93%).
Example 77
Synthesis of Myr-GABA-ONSu
[1393] To a solution of Myr-ONSu (4 g, 12.3 mmol) in DMF (350 ml)
was added EDPA (1.58 g, 12.3 mmol) and ?-aminobutyric acid (1.26 g,
12.3 mmol). The resulting mixture was stirred at ambient
temperature for 18 h. Water (50 ml) was added and the solution
stirred for 1 h at room temperature. The solvents were removed in
vacuo to give a solid. The solid residue was dissolved in DMF (75
ml) and the solution added drop by drop to a 5% aqueous solution of
citric acid (250 ml). The precipitate collected, washed with water
(100 ml) and dried in vacuo to give the free acid intermediate
(3.65 g, 95%). To a solution of the free acid intermediate (3 g,
9.6 mmol), N-hydroxysuccinimide (1.65 g, 14.4 mmol) and
N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (3.67
g, 19.1 mmol) in DMF (330 ml) was stirred for 18 h at room
temperature, and the solvent removed in vacuo to give a solid. The
solid residue was dissolved in dichloromethane (100 ml) and washed
with brine (100 ml). The organic phase was dried (MgSO.sub.4) and
concentrated in vacuo to give a solid. The solid residue was
recrystallised from n-heptane (75 ml) to give the title compound
(2.8 g, 71%).
Example 78
Synthesis of Pal-?-Ala-ONSu
[1394] To a solution of Pal-ONSu (0.9 g, 2.8 mmol) in DMF (100 ml)
were added N-hydroxysuccinimide (0.35 g, 3 mmol) and
N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide (0.79 g, 4.1 mmol).
The resulting mixture was stirred at ambient temperature for 40 h,
and the solvent removed in vacuo. The solid residue was partitioned
between water (50 ml) and dichloromethane (50 ml). The organic
phase was separated, dried (MgSO.sub.4) and the solvent removed in
vacuo to give the title compound (1.1 g, 94%).
Example 79
Synthesis of
Arg.sup.34,Lys.sup.26(N.sup.?-(?-alanyl(N.sup.?-hexadecanoyl)))
GLP-1(7-37)
[1395] To a mixture of Arg.sup.34-GLP-1(7-37)--OH (19.2 mg, 5.7
?mol), EDPA (20.5 mg, 159 ?mol), NMP (2.7 ml) and water (1.35 ml)
was added a solution Pal-?-Ala-ONSu (7.2 mg, 17 ?mol), prepared as
described in example 79, in NMP (181 ?l). The reaction mixture was
gently shaken for 5 min., and then allowed to stand for an
additional 90 min. at room temperature. The reaction was quenched
by the addition of a solution of glycine (9.3 mg, 125 ?mol) in
water (93 ?l). The reaction mixture was purified by column
chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a
standard acetonitril/TFA system. The column was heated to 65?C and
the acetonitril gradient was 0-100% in 60 minutes. The title
compound (11.6 mg, 55%) was isolated, and the product was analysed
by PDMS. The m/z value for the protonated molecular ion was found
to be 3694.+-.3. The resulting molecular weight was thus 3693.+-.3
AMU (theoretical value 3693 AMU).
Example 80
Synthesis of Pal-Glu(OBu.sup.t)--ONSu
[1396] To a solution of H-Glu(OH)--OBu.sup.t (2.7 g, 11.3 mmol) and
Pal-ONSu (3.98 g, 11.3 mmol) in DMF (300 ml) was added EDPA (3.2 g,
24.8 mmol). The resulting mixture was stirred at ambient
temperature for 18 h, and the solvent concentrated in vacuo to give
an oil. The oily residue was dissolved in DMF (60 ml) and the
solution added drop by drop to a 10% aqueous solution of citric
acid (300 ml) whereby a precipitate was formed. The precipitate was
collected, washed with cold water (25 ml), and dried in vacuo to
give free acid intermediate (4.44 g, 89%). The free acid
intermediate (4 g, 9.1 mmol) was dissolved in DMF (50 ml) and
N-hydroxysuccinimide (1.15 g, 10 mmol) and
N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (2.6
g, 13.6 mmol) were added. The resulting mixture was stirred at room
temperature for 60 h, the solvent concentrated in vacuo to give the
crude title compound (8.2 g)
Example 81
Synthesis of
Arg.sup.34,Lys.sup.26(N.sup.?-(?-glutamyl(N.sup.?-hexadecanoyl)))
GLP-1(7-37)
[1397] To a mixture of Arg.sup.34-GLP-1(7-37)--OH (25.6 mg, 7.6
?mol), EDPA (27.4 mg, 212 ?mol), NMP (3.5 ml) and water (1.75 ml)
was added a solution of Pal-Glu(OBu.sup.t)-ONSu (12.2 mg, 22.7
?mol), prepared as described in example 80, in NMP (305 ?l). The
reaction mixture was gently shaken for 5 min., and then allowed to
stand for an additional 100 min. at room temperature. The reaction
was quenched by the addition of a solution of glycine (12.5 mg, 168
?mol) in water (125 ?l). A 0.5% aqueous solution of ammonium
acetate (72.5 ml) was added, and the resulting mixture eluted onto
a Varian 5 g C8 Mega Bond Elut.RTM., the immobilised compound
washed with 5% aqueous acetonitril (25 ml), and finally liberated
from the cartridge by elution with TFA (30 ml). The eluate was
concentrated in vacuo, and the residue purified by column
chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a
standard acetonitril/TFA system. The column was heated to 65?C and
the acetonitril gradient was 0-100% in 60 minutes. The title
compound (6.1 mg, 22%) was isolated, and the product was analysed
by PDMS. The m/z value for the protonated molecular ion was found
to be 3751.+-.3. The resulting molecular weight was thus 3750.+-.3
AMU (theoretical value 3751 AMU).
Example 82
Synthesis of Ste-GABA-ONSu
[1398] To a solution of Ste-ONSu (3 g, 7.9 mmol) in DMF (270 ml)
was added EDPA (1 g, 7.9 mmol) and a solution of ?-aminobutyric
acid (0.81 g, 7.9 mmol) in water (40 ml). The resulting suspension
was stirred at ambient temperature for 18 h, and then concentrated
in vacuo to a final volume of 50 ml. The resulting suspension was
added to a 5% aqueous solution of citric acid (500 ml) whereby a
precipitate is formed. The precipitate was collected and washed
with water (50 ml), and dried in vacuo for 4 h to give the free
acid intermediate (2.8 g, 97%). To a mixture of the free acid
intermediate (2.6 g, 7 mmol), N-hydroxysuccinimide (1.21 g, 10.5
mmol) and N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide
hydrochloride (2.69 g, 14 mmol) in NMP (300 ml) was stirred for 70
h, and the solvent removed in vacuo to give a solid. The solid
residue was dissolved in dichloromethane (100 ml) and washed with
brine (2.times.100 ml). The organic phase was dried (MgSO.sub.4)
and concentrated in vacuo to give a solid. The solid residue was
recrystallised from n-heptane (75 ml) to give the title compound
(2.2 g, 67%).
Example 83
Synthesis of Pal-Isonip-ONSu
[1399] To a suspension of 1-hexadecanoylbenzotriazole (3 g, 8.4
mmol), prepared as described in the literature (Kreutzberger; van
der Goot, Arch.Pharm., 307, 1974), in DMF (350 ml) were added EDPA
(1.08 g, 8.4 mmol) and a solution of piperidine-4-carboxylic acid
in water (20 ml). The resulting suspension was stirred at room
temperature for 12d, and then concentrated in vacuo to an oil. The
oily residue was added drop by drop to a 5% aqueous solution of
citric acid (300 ml) whereby a precipitate was formed. The
precipitate was collected and washed with water (50 ml), dried in
vacuo for 2 h to give the free acid intermediate (3 g, 97%). To a
solution of the free acid intermediate (2.8 g, 7.6 mmol),
N-hydroxysuccinimide (1.31 g, 11.4 mmol) in DMF (250 ml) was added
N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (2.92
g, 15.2 mmol). The resulting mixture was stirred at ambient
temperature for 18 h, and the solvent removed in vacuo to give an
oil. The oily residue was dissolved in dichloromethane (100 ml),
washed with brine (50 ml), dried (MgSO.sub.4) and concentrated in
vacuo to give the crude title compound (4.1 g, quant.).
Example 84
Synthesis of
Arg.sup.34,Lys.sup.26(N.sup.?-(piperidinyl-4-carbonyl(N-hexadecanoyl)))
GLP-1(7-37)
[1400] To a mixture of Arg.sup.34-GLP-1(7-37)--OH (25 mg, 7.4
?mol), EDPA (26.7 mg, 207 ?mol), NMP (3.5 ml) and water (1.75 ml)
was added a solution Pal-Isonip-ONSu (13.7 mg, 30 ?mol), prepared
as described in example 83 in NMP (343 ?l). The reaction mixture
was gently shaken for 5 min., and then allowed to stand for an
additional 90 min. at room temperature. The reaction was quenched
by the addition of a solution of glycine (12.2 mg, 163 ?mol) in
water (122 ?l). The reaction mixture was purified by column
chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a
standard acetonitril/TFA system. The column was heated to 65?C and
the acetonitril gradient was 0-100% in 60 minutes. The title
compound (12 mg, 44%) was isolated, and the product was analysed by
PDMS. The m/z value for the protonated molecular ion was found to
be 3734.+-.3. The resulting molecular weight was thus 3733.+-.3 amu
(theoretical value 3733 amu).
Example 85
Synthesis of
Arg.sup.34,Lys.sup.26(N.sup.?-(?-glutamyl(N.sup.?-decanoyl)))
GLP-1(7-37)
[1401] To a mixture of Arg.sup.34-GLP-1(7-37)--OH (25 mg, 7.4
?mol), EDPA (26.7 mg, 207 ?mol), NMP (3.5 ml) and water (1.75 ml)
was added a solution of Cac-Glu(ONSu)-OBu.sup.t (10 mg, 22.1 ?mol)
in NMP (252 ?l). The reaction mixture was gently shaken for 5 min.,
and then allowed to stand for an additional 140 min. at room
temperature. The reaction was quenched by the addition of a
solution of glycine (12.2 mg, 162 ?mol) in water (122 ?l). A 0.5%
aqueous solution of ammonium acetate (73 ml) was added, and the
resulting mixture eluted onto a Varian 5 g C8 Mega Bond Elut.RTM.,
the immobilised compound washed with 5% aqueous acetonitril (25
ml), and finally liberated from the cartridge by elution with TFA
(25 ml). The eluate was concentrated in vacuo, and the residue
purified by column chromatography using a cyanopropyl column
(Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column
was heated to 65?C and the acetonitril gradient was 0-100% in 60
minutes. The title compound (12.2 mg, 45%) was isolated, and the
product was analysed by PDMS. The m/z value for the protonated
molecular ion was found to be 3669.7.+-.3. The resulting molecular
weight was thus 3668.7.+-.3 amu (theoretical value 3667 amu).
Example 86
General Method A
Synthesis of alkanoic acid 2,5-dioxopyrrolidin-1-yl ester:
[1402] To a solution of the alkanoic acid (34.7 mmol) and
N-hydroxysuccinimide (4 g, 34.7 mmol) in anhydrous acetonitril (10
ml) was added a solution of DCC (7.15 g, 34.7 mmol) in anhydrous
dichloromethane (15 ml), and the resulting reaction mixture was
stirred for 16 h at room temperature. The precipitated solid was
filtered off and recrystallised from a mixture of n-heptane and
2-propanol. The precipitate was dried in vacuo for 16 h to give the
title compound.
Synthesis of Lys(N.sup.?-alkanoyl)-peptide
[1403] To a mixture of the peptide (5.9 ?mol), EDPA (21 mg, 164
?mol), NMP (5.8 ml) and water (2.9 ml) was added a solution of the
alkanoic acid 2,5-dioxopyrrolidin-1-yl ester (37 ?mol), prepared as
described above, in NMP (0.5 ml). The reaction mixture was gently
shaken for 5 min at room temperature, and then allowed to stand for
an additional 2 h at room temperature. The reaction was quenched by
the addition of a solution of glycine (9.7 mg, 129 ?mol) in water
(97 ?l). The solvent was removed in vacuo, and the residue was
purified by column chromatography using a cyanopropyl column
(Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column
was heated to 65?C and the acetonitril gradient was 0-100% for 60
minutes.
[1404] Coupling of a desired group A comprising the 5- or
6-membered ring system Y to the N-terminal end of the peptide may
be performed using solid phase protein synthesis techniques as
explained above.
Example 87
General Method B
Synthesis of N.sup.?-alkanoyl-(L)-glutamic acid
?-tert-butyl-?-(2,5-dioxopyrrolidin-1-yl) diester:
[1405] A suspension of the alkanoic acid 2,5-dioxopyrrolidin-1-yl
ester (16.2 mmol), prepared as described under General method A,
(L)-glutamic acid ?-tert-butyl ester (3.28 g, 16.2 mmol), DMF (268
ml) and EDPA (2.1 g, 16.2 mmol) was stirred for 64 h at room
temperature. The reaction mixture was concentrated in vacuo and the
residue was dissolved in ethyl acetate (50 ml). The resulting
solution was washed with 5% aqueous citric acid (2.times.25 ml).
The solvent was concentrated removed in vacuo and the residue
dissolved in DMF (36 ml). The resulting solution was carefully
added to a 10% aqueous solution of citric acid (357 ml) and
extracted with ethyl acetate (200 ml) and dried (MgSO.sub.4). The
solvent was concentrated removed in vacuo to give the crude
glutamic diester intermediate. To a mixture of the crude diester,
N-hydroxysuccinimide (1.85 g, 16.1 mmol) and anhydrous DMF (25 ml)
was added a solution of DCC (3.32 g, 16.1 mmol) in anhydrous
dichloromethane (15 ml). The resulting mixture was stirred at
ambient temperature for 20 h. The reaction mixture was filtered and
the solvent was concentrated removed in vacuo. The residue was
purified on a silica gel column (40-63 ??) and eluted with a
mixture of dichloromethane and acetonitril (1:1) to give the title
compound.
Synthesis of Lys(N.sup.?-(?-glutamyl(N.sup.?-alkanoyl)))peptide
[1406] To a mixture of the peptide (4.2 ?mol), EDPA (15.3 mg, 119
?mol), NMP (2 ml) and water (1 ml) was added a solution of
N.sup.?-alkanoyl-(L)-glutamic acid
?-tert-butyl-?-(2,5-dioxopyrrolidin-1-yl) diester (12.7 ?mol),
prepared as described above, in NMP (135 ml). The reaction mixture
was gently shaken for 5 min at room temperature and then allowed to
stand for an additional 2 h at room temperature. The reaction was
quenched by the addition of a solution of glycine (7 mg, 93 ?mol)
in water (698 ?l). A 0.5% aqueous solution of ammonium acetate (42
ml) was added, and the resulting mixture was eluted onto a Varian 5
g C8 Mega Bond Elut.RTM. cartridge, the immobilised compound was
washed with 5% aqueous acetonitril (25 ml) and finally liberated
from the cartridge by elution with TFA (25 ml). The eluate was
concentrated in vacuo, and the residue was purified by column
chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a
standard acetonitril/TFA system. The column was heated to 65?C and
the acetonitril gradient was 0-100% for 60 minutes.
[1407] Coupling of a desired group A comprising the 5- or
6-membered ring system Y to the N-terminal end of the peptide may
be performed using solid phase protein synthesis techniques as
explained above.
Example 88
Synthesis of N-terminal modified peptides
[1408] Peptides were synthesised according to the Fmoc strategy on
an Applied Biosystems 431 A peptide synthesiser in 0.25 mmol scale
using the manufacturer supplied FastMoc UV protocols starting with
a Fmoc-Gly-Wang resin (NovaBiochem). The protected amino acid
derivatives used were commercially obtained Fmoc amino acids, and
Adoc-Imidazolylpropionic acid. The derivatives used where side
chain protection was needed were: Fmoc-Arg(Pmc), Fmoc-Trp(Boc),
Fmoc-Glu(OBut), Fmoc-Lys(Boc), Fmoc-Gln(Trt), Fmoc-Tyr(But),
Fmoc-Ser(But), Fmoc-Thr(But), Fmoc-His(Trt) and Fmoc-Asp(OBut), and
Adoc-Imidazolylpropionic acid.
[1409] The peptides were cleaved from the resin and side chain
deprotected in TFA/phenol/thioanisole/water/ethanedithiol
(83.25:6.25:4.25:4.25:2.00) for 180 min. The cleavage mixture was
filtered and the filtrate was concentrated by a stream of nitrogen.
The crude peptide was precipitated from this oil with diethyl ether
and washed twice with diethyl ether. After drying the crude peptide
was dissolved in 50% aqueous acetic acid and diluted to 10% acetic
acid with water and purified by semipreparative HPLC on a 25
mm.times.250 mm column packed with 7 ?m C-18 silica. The column was
eluted with a gradient of acetonitril against 0.05 M
(NH.sub.4).sub.2SO.sub.4, pH 2.5 at 10 ml/min. at 40?C. The
peptide-containing fractions were collected, diluted with 3 volumes
of water and applied to a Sep-Pak.RTM. C18 cartridge (Waters part.
51910) which was equilibrated with 0.1% TFA. The peptide was eluted
from the Sep-Pak.RTM. cartridge with 70% acetonitrile/0.1% TFA,
water and isolated from the eluate by lyophilization after dilution
with water. The final product obtained was characterised by amino
acid analysis, analytical RP-HPLC and by PDMS. Amino acid analysis
and mass spectrometry agreed with the expected structure within the
experimental error of the method (mass spectrometry +/-2 amu, amino
acid analysis +/-10%, RP-HPLC showed a peptide purity>95%).
[1410] The RP-HPLC analysis was performed using UV detection at 214
nm and a Vydac 218TP54 4.6 mm.times.250 mm, 5 ?m C-18 silica column
which was eluted at 1 ml/min. at 42.degree. C. Two different
elution conditions were used: a gradient of 5-60% acetonitrile/0.1
M ammonium sulfate, water pH 2.5; and a gradient of 5-60%
acetonitrile, 0.1% TFA/0.1% TFA, water.
Example 89
Synthesis of Cap-Glu(ONSu)-OBu.sup.t
[1411] To a solution of octanoic acid (5 g, 34.7 mmol) and
N-hydroxysuccinimide (4 g, 34.7 mmol) in anhydrous acetonitril (10
ml) was added a solution of DCC (7.15 g, 34.7 mmol) in anhydrous
dichloromethane (15 ml), and the resulting reaction mixture stirred
for 16 h at room temperature. The precipitated solid was filtered
off and recrystallised from a mixture of n-heptane (40 ml) and
2-propanol (2 ml). The precipitate was dried in a vacuum drying
oven for 16 h to give the intermediate Cap-ONSu. A suspension of
the crude ester intermediate (3.9 g, 16.2 mmol),
(L)--H-Glu(OH)--OBu.sup.t (3.28 g, 16.2 mmol), DMF (268 ml) and
EDPA (2.1 g, 16.2 mmol) was stirred for 64 h at room temperature.
The reaction mixture was concentrated in vacuo and the residue
dissolved in ethyl acetate (50 ml). The resulting solution was
washed with 5% aqueous citric acid (2.times.25 ml). The solvent was
concentrated in vacuo and the residue dissolved in DMF (36 ml). The
resulting solution was added drop wise to a 10% aqueous solution of
citric acid (357 ml) and extracted with ethyl acetate (200 ml), and
dried (MgSO.sub.4). The solvent was concentrated in vacuo to give
the crude glutamic acid intermediate. To a mixture of the crude
glutamic acid intermediate, N-hydroxysuccinimide (1.85 g, 16.1
mmol) and DMF (25 ml) was added a solution of DCC (3.32 g, 16.1
mmol) in dichloromethane (15 ml). The resulting mixture was stirred
at ambient temperature for 20 h. The reaction mixture was filtered
and the solvent concentrated in vacuo. The residue was purified on
a silica gel column (40-63 ?m), eluted with a mixture of
dichloromethane and acetonitril (1:1) to give the title compound
(0.63 g, 6% over all).
Example 90
Synthesis of
desamino-His.sup.7,Arg.sup.34,Lys.sup.26(N.sup.?-(?-glutamyl(N.sup.?-hexa-
decanoyl))) GLP-1(7-37)
[1412] To a mixture of
desamino-His.sup.7,Arg.sup.34-GLP-1(7-37)--OH (20 mg, 5.9 ?mol),
EDPA (21.5 mg, 166 ?mol), NMP (2.8 ml) and water (1.4 ml) was added
a solution Pal-Glu(ONSu)-OBu.sup.t (9.6 mg, 17.8 ?mol in NMP (240
?l). The reaction mixture was gently shaken for 5 min., and then
allowed to stand for an additional 75 min. at room temperature. The
reaction was quenched by the addition of a solution of glycine (9.8
mg, 130 ?mol) in water (979 ?l). A 0.5% aqueous solution of
ammonium acetate (58 ml) was added, and the resulting mixture
eluted onto a Varian 5 g C8 Mega Bond Elut.RTM., the immobilised
compound washed with 5% aqueous acetonitril (25 ml), and finally
liberated from the cartridge by elution with TFA (25 ml). The
eluate was concentrated in vacuo, and the residue purified by
column chromatography using a cyanopropyl column (Zorbax 300SB-CN)
and a standard acetonitril/TFA system. The column was heated to
65?C and the acetonitril gradient was 0-100% in 60 minutes. The
title compound (9.1 mg, 41%) was isolated, and the product was
analysed by PDMS. The m/z value for the protonated molecular ion
was found to be 3739.+-.3. The resulting molecular weight was thus
3738.+-.3 amu (theoretical value 3736 amu).
Example 91
Synthesis of Myr-GABA-ONSu
[1413] To a solution of Myr-ONSu (4 g, 12.3 mmol) in DMF (350 ml)
was added EDPA (1.58 g, 12.3 mmol) and ?-aminobutyric acid (1.26 g,
12.3 mmol). The resulting mixture was stirred at ambient
temperature for 18 h. Water (50 ml) was added and the solution
stirred for 1 h at room temperature. The solvents were removed in
vacuo to give a solid. The solid residue was dissolved in DMF (75
ml) and the solution added drop by drop to a 5% aqueous solution of
citric acid (250 ml). The precipitate collected, washed with water
(100 ml) and dried in vacuo to give the free acid intermediate
(3.65 g, 95%). To a solution of the free acid intermediate (3 g,
9.6 mmol), N-hydroxysuccinimide (1.65 g, 14.4 mmol) and
N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide hydrochloride (3.67
g, 19.1 mmol) in DMF (330 ml) was stirred for 18 h at room
temperature, and the solvent removed in vacuo to give a solid. The
solid residue was dissolved in dichloromethane (100 ml) and washed
with brine (100 ml). The organic phase was dried (MgSO.sub.4) and
concentrated in vacuo to give a solid. The solid residue was
recrystallised from n-heptane (75 ml) to give the title compound
(2.8 g, 71%).
Example 92
Synthesis of
desamino-His.sup.7,Arg.sup.34,Lys.sup.26(N.sup.?-(?-aminobutyroyl(N.sup.?-
-hexadecanoyl))) GLP-1(7-37)
[1414] To a mixture of
desamino-His.sup.7,Arg.sup.34-GLP-1(7-37)--OH (20 mg, 8.9 ?mol),
EDPA (21.5 mg, 166 ?mol), NMP (2.8 ml) and water (1.4 ml) was added
a solution Pal-GABA-ONSu (7.8 mg, 17.8 ?mol) in NMP (181 ?l). The
reaction mixture was gently shaken for 5 min., and then allowed to
stand for an additional 90 min. at room temperature. The reaction
was quenched by the addition of a solution of glycine (9.3 mg, 125
?mol) in water (93 ?l). The reaction mixture was purified by column
chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a
standard acetonitril/TFA system. The column was heated to 65?C and
the acetonitril gradient was 0-100% in 60 minutes. The title
compound (11.6 mg, 55%) was isolated, and the product was analysed
by PDMS. The m/z value for the protonated molecular ion was found
to be 3692.+-.3. The resulting molecular weight was thus 3691.+-.3
amu (theoretical value 3693 amu).
Example 93
5 Synthesis of
desamino-His.sup.7,Arg.sup.34,Lys.sup.26(N.sup.?-(?-alanyl(N.sup.?-hexade-
canoyl))) GLP-1(7-37)
[1415] To a mixture of
desamino-His.sup.7,Arg.sup.34-GLP-1(7-37)--OH (25 mg, 7.4 ?mol),
EDPA (26.8 mg, 208 ?mol), NMP (3.5 ml) and water (1.75 ml) was
added a solution Pal-?-Ala-ONSu (9.4 mg, 22.2 ?mol) in NMP (236
?l). The reaction mixture was gently shaken for 5 min., and then
allowed to stand for an additional 130 min. at room temperature.
The reaction was quenched by the addition of a solution of glycine
(12.2 mg, 163 ?mol) in water (122 ?l). The reaction mixture was
purified by column chromatography using a cyanopropyl column
(Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column
was heated to 65?C and the acetonitril gradient was 0-100% in 60
minutes. The title compound (13.4 mg, 49%) was isolated, and the
product was analysed by PDMS. The m/z value for the protonated
molecular ion was found to be 3681.+-.3. The resulting molecular
weight was thus 3680 i 3 amu (theoretical value 3678 amu).
Example 94
Synthesis of Ste-GABA-ONSu
[1416] To a solution of Ste-ONSu (3 g, 7.9 mmol) in DMF (270 ml)
was added EDPA (1 g, 7.9 mmol) and a solution of ?-aminobutyric
acid (0.81 g, 7.9 mmol) in water (40 ml). The resulting suspension
was stirred at ambient temperature for 18 h, and then concentrated
in vacuo to a final volume of 50 ml. The resulting suspension was
added to a 5% aqueous solution of citric acid (500 ml) whereby a
precipitate is formed. The precipitate was collected and washed
with water (50 ml), and dried in vacuo for 4 h to give the free
acid intermediate (2.8 g, 97%). To a mixture of the free acid
intermediate (2.6 g, 7 mmol), N-hydroxysuccinimide (1.21 g, 10.5
mmol) and N-(3-dimethylaminopropyl)-N'-ethylcarbodiimide
hydrochloride (2.69 g, 14 mmol) in NMP (300 ml) was stirred for 70
h, and the solvent removed in vacuo to give a solid. The solid
residue was dissolved in dichloromethane (100 ml) and washed with
brine (2.times.100 ml). The organic phase was dried (MgSO.sub.4)
and concentrated in vacuo to give a solid. The solid residue was
recrystallised from n-heptane (75 ml) to give the title compound
(2.2 g, 67%).
Example 95
Synthesis of
Arg.sup.34Ala.sup.8(N.sup.?-(imidazol-4-ylprop-2-enoyl),Lys.sup.26(N.sup.-
?-(?-aminobutyroyl(N.sup.?-hexadecanoyl))) GLP-1(8-37)
[1417] To a mixture
Arg.sup.34,Ala.sup.8(N.sup.?-(imidazol-4-ylprop-2-enoyl)-GLP-1(8-37)--OH
(5.6 mg, 1.7 ?mol), EDPA (6 mg, 46.2 ?mol), NMP (0.78 ml) and water
(0.39 ml) was added a solution Pal-GABA-ONSu (2.2 mg, 5 ?mol) in
NMP (54 ?l). The reaction mixture was gently shaken for 5 min., and
then allowed to stand for an additional 80 min. at room
temperature. The reaction was quenched by the addition of a
solution of glycine (2.7 mg, 36 ?mol) in water (27 ?l). The
reaction mixture was purified by column chromatography using a
cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA
system. The column was heated to 65?C and the acetonitril gradient
was 0-100% in 60 minutes. The title compound (1.9 mg, 31%) was
isolated, and the product was analysed by PDMS. The m/z value for
the protonated molecular ion was found to be 3690.+-.3. The
resulting molecular weight was thus 3689.+-.3 amu (theoretical
value 3690 amu).
Example 96
Synthesis of
Arg.sup.34,Ala.sup.8(N.sup.?-(imidazol-4-ylacetyl),Lys.sup.26(N.sup.?-(?--
aminobutyroyl(N.sup.?-hexadecanoyl))) GLP-1(8-37)
[1418] To a mixture of
Arg.sup.34,Ala.sup.8(N.sup.?-(imidazol-4-ylacetyl)-GLP-1(8-37)--OH
(5.3 mg, 1.6 ?mol), EDPA (5.7 mg, 43.9 ?mol), NMP (0.74 ml) and
water (0.37 ml) was added a solution Pal-GABA-ONSu (2 mg, 4.7 ?mol)
in NMP (52 ?l). The reaction mixture was gently shaken for 5 min.,
and then allowed to stand for an additional 80 min. at room
temperature. The reaction was quenched by the addition of a
solution of glycine (2.6 mg, 34 ?mol) in water (26 ?l). The
reaction mixture was purified by column chromatography using a
cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA
system. The column was heated to 65?C and the acetonitril gradient
was 0-100% in 60 minutes. The title compound (2.2 mg, 38%) was
isolated, and the product was analysed by PDMS. The m/z value for
the protonated molecular ion was found to be 3676.+-.3. The
resulting molecular weight was thus be 3675.+-.3 amu (theoretical
value 3678 amu).
Example 97
Synthesis of
desamino-His.sup.7,Arg.sup.34,Lys.sup.26(N.sup.?-(?-aminobutyroyl(N.sup.?-
-tetradecanoyl))) GLP-1(7-37)
[1419] To a mixture of
desamino-His.sup.7,Arg.sup.34-GLP-1(7-37)--OH (25 mg, 7.4 ?mol),
EDPA (26.9 mg, 208 ?mol), NMP (3.5 ml) and water (1.75 ml) was
added a solution Myr-GABA-ONSu (9.1 mg, 22.2 ?mol), prepared as
described in example 91, in NMP (228 ?l). The reaction mixture was
gently shaken for 5 mm., and then allowed to stand for an
additional 90 min. at room temperature. The reaction was quenched
by the addition of a solution of glycine (12.2 mg, 163 ?mol) in
water (122 ?l). The reaction mixture was purified by column
chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a
standard acetonitril/TFA system. The column was heated to 65?C and
the acetonitril gradient was 0-100% in 60 minutes. The title
compound (10.5 mg, 39%) was isolated, and the product was analysed
by PDMS. The m/z value for the protonated molecular ion was found
to be 3667.+-.3. The resulting molecular weight was thus 3664.+-.3
amu (theoretical value 3662 amu).
Example 98
Synthesis of
desamino-His.sup.7,Arg.sup.34,Lys.sup.26(N.sup.?-(?-aminobutyroyl(N.sup.?-
-octadecanoyl))) GLP-1(7-37)
[1420] To a mixture of
desamino-His.sup.7,Arg.sup.34-GLP-1(7-37)--OH (25 mg, 7.4 ?mol),
EDPA (26.8 mg, 207 ?mol), NMP (3.5 ml) and water (1.75 ml) was
added a solution Ste-GABA-ONSu (10.4 mg, 22.2 ?mol), prepared as
described in example 94, in NMP (259 ?l). The reaction mixture was
gently shaken for 5 min., and then allowed to stand for an
additional 170 min. at room temperature. The reaction was quenched
by the addition of a solution of glycine (12.2 mg, 163 ?mol) in
water (122 ?l) and the reaction mixture purified by column
chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a
standard acetonitril/TFA system. The column was heated to 65?C and
the acetonitril gradient was 0-100% in 60 minutes. The title
compound (7 mg, 25%) was isolated, and the product was analysed by
PDMS. The m/z value for the protonated molecular ion was found to
be 3719.+-.3. The resulting molecular weight was thus 3718.+-.3 amu
(theoretical value 3720 amu).
Example 99
General Method A
Synthesis of alkanoic acid 2,5-dioxopyrrolidin-1-yl ester:
[1421] To a solution of the alkanoic acid (34.7 mmol) and
N-hydroxysuccinimide (4 g, 34.7 mmol) in anhydrous acetonitril (10
ml) was added a solution of DCC (7.15 g, 34.7 mmol) in anhydrous
dichloromethane (15 ml), and the resulting reaction mixture was
stirred for 16 h at room temperature. The precipitated solid was
filtered off and recrystallised from a mixture of n-heptane and
2-propanol. The precipitate was dried in vacuo for 16 h to give the
title compound.
Synthesis of Lys(N.sup.?-alkanoyl)-peptide
[1422] To a mixture of the desired parent peptide (5.9 ?mol), EDPA
(21 mg, 164 ?mol), NMP (5.8 ml) and water (2.9 ml) was added a
solution of the alkanoic acid 2,5-dioxopyrrolidin-1-yl ester (37
?mol), prepared as described above, in NMP (0.5 ml). The reaction
mixture was gently shaken for 5 min at room temperature, and then
allowed to stand for an additional 2 h at room temperature. The
reaction was quenched by the addition of a solution of glycine (9.7
mg, 129 ?mol) in water (97 ?l). The solvent was removed in vacuo,
and the residue was purified by column chromatography using a
cyanopropyl column (Zorbax 300SB-CN) and a standard acetonitril/TFA
system. The column was heated to 65?C and the acetonitril gradient
is 0-100% for 60 minutes.
General Method B
Synthesis of N.sup.?-alkanoyl-(L)-glutamic acid
?-tert-butyl-?-(2,5-dioxopyrrolidin-1-yl) diester:
[1423] A suspension of the alkanoic acid 2,5-dioxopyrrolidin-1-yl
ester (16.2 mmol), prepared as described under General method A,
(L)-glutamic acid ?-tert-butyl ester (3.28 g, 16.2 mmol), DMF (268
ml) and EDPA (2.1 g, 16.2 mmol) was stirred for 64 h at room
temperature. The reaction mixture was concentrated in vacuo and the
residue was dissolved in ethyl acetate (50 ml). The resulting
solution was washed with 5% aqueous citric acid (2.times.25 ml).
The solvent was removed in vacuo and the residue dissolved in DMF
(36 ml). The resulting solution was carefully added to a 10%
aqueous solution of citric acid (357 ml) and extracted with ethyl
acetate (200 ml) and dried (MgSO.sub.4). The solvent was removed in
vacuo to give the crude glutamic diester intermediate. To a mixture
of the crude diester, N-hydroxysuccinimide (1.85 g, 16.1 mmol) and
anhydrous DMF (25 ml) was added a solution of DCC (3.32 g, 16.1
mmol) in anhydrous dichloromethane (15 ml). The resulting mixture
was stirred at ambient temperature for 20 h. The reaction mixture
was filtered and the solvent was removed in vacuo. The residue was
purified on a silica gel column (40-63 ?m) and eluted with a
mixture of dichloromethane and acetonitril (1:1) to give the title
compound.
Synthesis of Lys(N.sup.?-(?-glutamyl(N.sup.?-alkanoyl)))peptide
[1424] To a mixture of the desired parent peptide (4.2 ?mol), EDPA
(15.3 mg, 119 ?mol), NMP (2 ml) and water (1 ml) was added a
solution of N.sup.?-alkanoyl-(L)-glutamic acid
?-tert-butyl-?-(2,5-dioxopyrrolidin-1-yl) diester (12.7 ?mol),
prepared as described above, in NMP (135 ml). The reaction mixture
was gently shaken for 5 min at room temperature and then allowed to
stand for an additional 2 h at room temperature. The reaction was
quenched by the addition of a solution of glycine (7 mg, 93 ?mol)
in water (698 ?l). A 0.5% aqueous solution of ammonium acetate (42
ml) was added, and the resulting mixture was eluted onto a Varian 5
g C8 Mega Bond Elut.RTM. cartridge, the immobilised compound was
washed with 5% aqueous acetonitril (25 ml) and finally liberated
from the cartridge by elution with TFA (25 ml). The eluate was
concentrated in vacuo, and the residue was purified by column
chromatography using a cyanopropyl column (Zorbax 300SB-CN) and a
standard acetonitril/TFA system. The column was heated to 65?C and
the acetonitril gradient is 0-100% for 60 minutes.
Example 100
Synthesis of
Arg.sup.34,Lys.sup.26(N.sup.?-(?-glutamyl(N.sup.?-tetradecanoyl)))
GLP-1(9-37)
[1425] To a mixture of Arg.sup.34-GLP-1(9-37)--OH (22.4 mg, 7.1
?mol), EDPA (25.5 mg, 197 ?mol), NMP (3.14 ml) and water (1.57 ml)
was added a solution of Myr-Glu(ONSu)-OBu.sup.t (10.8 mg, 21.2
?mol) in NMP (270 ?l). The reaction mixture was gently shaken for 5
min., and then allowed to stand for an additional 2 h at room
temperature. The reaction was quenched by the addition of a
solution of glycine (11.6 mg, 155 ?mol) in water (116 ?l). A 0.5%
aqueous solution of ammonium acetate (67 ml) was added, and the
resulting mixture eluted onto a Varian 5 g C8 Mega Bond Elut.RTM.,
the immobilised compound washed with 5% aqueous acetonitril (25
ml), and finally liberated from the cartridge by elution with TFA
(25 ml). The eluate was concentrated in vacuo, and the residue
purified by column chromatography using a cyanopropyl column
(Zorbax 300SB-CN) and a standard acetonitril/TFA system. The column
was heated to 65?C and the acetonitril gradient was 0-100% in 60
minutes. The title compound (2.3 mg, 9.2%) was isolated, and the
product was analysed by PDMS. The m/z value for the protonated
molecular ion was found to be 3516.0.+-.3. The resulting molecular
weight was thus 3515.0.+-.3 amu (theoretical value 3515 amu).
Example 101
[1426] In this example and examples 102 and 103,
[1427] the phrase "8 mM phosphate buffer of pH 7.4" means 4 mM
NaH.sub.2PO.sub.4, 2H.sub.2O and 4 mM Na.sub.2HPO.sub.4, 2H.sub.2O
pH adjusted to 7.4 (using Sodium Hydroxide and/or Hydrochloric
acid).
[1428] the term "Compound 1" means
Arg.sup.34,Lys.sup.26(N.sup.?-(.sup.?-Glu(N.sup.?-tetradecanoyl)))
GLP-1(7-37).
[1429] the term "Compound 2" means
Arg.sup.34,Lys.sup.26(N.sup.?-(.sup.?-Glu(N.sup.?-hexadecanoyl)))
GLP-1(7-37).
[1430] the term "Compound 3" means
Arg.sup.26,34,Lys.sup.36(N.sup.?-(?-Glu(N.sup.?-hexadecanoyl)))
GLP-1(7-36).
[1431] the term "Compound 4" means
Arg.sup.26,Lys.sup.34(N.sup.?-(.sup.?-Glu(N.sup.?-hexadecanoyl)))
GLP-1(7-37).
[1432] the term "Compound 5" means
Gly.sup.8,Glu.sup.37,Arg.sup.26,34Lys.sup.38(N.sup.?-(.sup.?-Glu(N.sup.?--
hexadecanoyl))) GLP-1(7-38).
General Example 101
[1433] TABLE-US-00005 Compound 2-7.5 mg/ml Mannitol 34-50 mg/ml
Phenol 5-7.5 mg/ml 8 mM phosphate buffer of pH 7.4
[1434] Mannitol and phenol were dissolved in the phosphate buffer
preadjusted to pH 7.4. The compound was then dissolved under slow
stirring. The pH was adjusted to 7.4 using sodium hydroxide and/or
hydrochloric acid. Finally, the formulation was sterilised by
filtration through an appropriate filter.
[1435] The following specific formulations were produced using this
procedure:
Example 101-A
[1436] TABLE-US-00006 Compound 1 2.0 mg/ml Mannitol 38 mg/ml Phenol
5 mg/ml 8 mM phosphate buffer of pH 7.4 ad 100 ml
Example 101-B
[1437] TABLE-US-00007 Compound 1 5 mg/ml Mannitol 36.9 mg/ml Phenol
5 mg/ml 8 mM phosphate buffer of pH 7.4 ad 100 ml
Example 101-C
[1438] TABLE-US-00008 Compound 1 7.5 mg/ml Mannitol 34 mg/ml Phenol
7.5 mg/ml 8 mM phosphate buffer of pH 7.4 ad 100 ml
Example 101-D
[1439] TABLE-US-00009 Compound 2 2.0 mg/ml Mannitol 38 mg/ml Phenol
5 mg/ml 8 mM phosphate buffer of pH 7.4 ad 100 ml
Example 101-E
[1440] TABLE-US-00010 Compound 2 5 mg/ml Mannitol 36.9 mg/ml Phenol
5 mg/ml 8 mM phosphate buffer of pH 7.4 ad 100 ml
Example 101-F
[1441] TABLE-US-00011 Compound 2 7.5 mg/ml Mannitol 34 mg/ml Phenol
7.5 mg/ml 8 mM phosphate buffer of pH 7.4 ad 100 ml
Example 101-G
[1442] TABLE-US-00012 Compound 3 2.0 mg/ml Mannitol 38 mg/ml Phenol
5 mg/ml 8 mM phosphate buffer of pH 7.4 ad 100 ml
Example 101-H
[1443] TABLE-US-00013 Compound 3 5 mg/ml Mannitol 36.9 mg/ml Phenol
5 mg/ml 8 mM phosphate buffer of pH 7.4 ad 100 ml
Example 101-I
[1444] TABLE-US-00014 Compound 3 7.5 mg/ml Mannitol 34 mg/ml Phenol
7.5 mg/ml 8 mM phosphate buffer of pH 7.4 ad 100 ml
Example 101-J
[1445] TABLE-US-00015 Compound 4 2.0 mg/ml Mannitol 38 mg/ml Phenol
5 mg/ml 8 mM phosphate buffer of pH 7.4 ad 100 ml
Example 101-K
[1446] TABLE-US-00016 Compound 4 5 mg/ml Mannitol 36.9 mg/ml Phenol
5 mg/ml 8 mM phosphate buffer of pH 7.4 ad 100 ml
Example 101-L
[1447] TABLE-US-00017 Compound 4 7.5 mg/ml Mannitol 34 mg/ml Phenol
7.5 mg/ml 8 mM phosphate buffer of pH 7.4 ad 100 ml
Example 102
[1448] TABLE-US-00018 Compound 2-7.5 mg/ml Mannitol 19-25 mg/ml
Benzyl Alcohol 14-18 mg/ml 8 mM phosphate buffer of pH 7.4
[1449] Mannitol and benzyl alcohol were dissolved in the phosphate
buffer preadjusted to pH 7.4. The compound was then dissolved under
slow stirring. The pH was adjusted to 7.4 using sodium hydroxide
and/or hydrochloric acid. Finally, the formulation was sterilised
by filtration through an appropriate filter.
[1450] The following specific formulations were produced using this
procedure:
Example 102-A
[1451] TABLE-US-00019 Compound 1 2.0 mg/ml Mannitol 25 mg/ml Benzyl
alcohol 14 mg/ml 8 mM phosphate buffer of pH 7.4 ad 100 ml
Example 102-B
[1452] TABLE-US-00020 Compound 1 7.5 mg/ml Mannitol 19 mg/ml Benzyl
alcohol 18 mg/ml 8 mM phosphate buffer of pH 7.4 ad 100 ml
Example 102-C
[1453] TABLE-US-00021 Compound 2 2.0 mg/ml Mannitol 25 mg/ml Benzyl
alcohol 14 mg/ml 8 mM phosphate buffer of pH 7.4 ad 100 ml
Example 102-D
[1454] TABLE-US-00022 Compound 2 7.5 mg/ml Mannitol 19 mg/ml Benzyl
alcohol 18 mg/ml 8 mM phosphate buffer of pH 7.4 ad 100 ml
Example 102-E
[1455] TABLE-US-00023 Compound 3 2.0 mg/ml Mannitol 25 mg/ml Benzyl
alcohol 14 mg/ml 8 mM phosphate buffer of pH 7.4 ad 100 ml
Example 102-F
[1456] TABLE-US-00024 Compound 3 7.5 mg/ml Mannitol 19 mg/ml Benzyl
alcohol 18 mg/ml 8 mM phosphate buffer of pH 7.4 ad 100 ml
Example 102-G
[1457] TABLE-US-00025 Compound 5 2.0 mg/ml Mannitol 25 mg/ml Benzyl
alcohol 14 mg/ml 8 mM phosphate buffer of pH 7.4 ad 100 ml
Example 102-H
[1458] TABLE-US-00026 Compound 5 7.5 mg/ml Mannitol 19 mg/ml Benzyl
alcohol 18 mg/ml 8 mM phosphate buffer of pH 7.4 ad 100 ml
Example 103
[1459] TABLE-US-00027 Compound 2-7.5 mg/ml Mannitol 42-44 mg/ml
Metacresol 2.5-4.0 mg/ml 8 mM phosphate buffer of pH 7.4
[1460] Mannitol and metacresol were dissolved in the phosphate
buffer preadjusted to pH 7.4. The compound was then dissolved under
slow stirring. The pH was adjusted to 7.4 using sodium hydroxide
and/or hydrochloric acid. Finally, the formulation was sterilised
by filtration through an appropriate filter.
[1461] The following specific formulations were produced using
this:
Example 103-A
[1462] TABLE-US-00028 Compound 1 2.0 mg/ml Mannitol 44 mg/ml
Metacresol 2.5 mg/ml 8 mM phosphate buffer of pH 7.4 ad 100 ml
Example 103-B
[1463] TABLE-US-00029 Compound 1 7.5 mg/ml Mannitol 42 mg/ml
Metacresol 4 mg/ml 8 mM phosphate buffer of pH 7.4 ad 100 ml
Example 103-C
[1464] TABLE-US-00030 Compound 2 2.0 mg/ml Mannitol 44 mg/ml
Metacresol 2.5 mg/ml 8 mM phosphate buffer of pH 7.4 ad 100 ml
Example 103-D
[1465] TABLE-US-00031 Compound 2 7.5 mg/ml Mannitol 42 mg/ml
Metacresol 4 mg/ml 8 mM phosphate buffer of pH 7.4 ad 100 ml
Example 103-E
[1466] TABLE-US-00032 Compound 3 2.0 mg/ml Mannitol 44 mg/ml
Metacresol 2.5 mg/ml 8 mM phosphate buffer of pH 7.4 ad 100 ml
Example 103-F
[1467] TABLE-US-00033 Compound 3 7.5 mg/ml Mannitol 42 mg/ml
Metacresol 4 mg/ml 8 mM phosphate buffer of pH 7.4 ad 100 ml
Example 103-G
[1468] TABLE-US-00034 Compound 5 2.0 mg/ml Mannitol 44 mg/ml
Metacresol 2.5 mg/ml 8 mM phosphate buffer of pH 7.4 ad 100 ml
Example 103-H
[1469] TABLE-US-00035 Compound 5 7.5 mg/ml Mannitol 42 mg/ml
Metacresol 4 mg/ml 8 mM phosphate buffer of pH 7.4 ad 100 ml
Example 104
[1470] Circular Dichroism (CD) at 222 nm as a function of peptide
concentration for peptides dissolved in 10 mM tris buffer, pH 8,
and 23?C was measured for native GLP-1(7-37) and the following
eight GLP-1 derivatives of the present invention:
(a) Example 37
(b) Example 50
(c) Example 63
(d) Example 51
(e) Example 55
(f) Example 61
(g) Example 68
(h) Example 64
[1471] The results are shown in FIG. 1. Note that the CD signal is
proportional to the average content of ?-helix in the peptides,
i.e., a CD value of -1 corresponds to 10% ?-helix content under
these conditions. The figure shows that, as the concentration of
native GLP-1(7-37) is raised between 25 and 1000 ?M, the content of
?-helix increases from about 15% to about 30-35% in parallel with
the formation of higher oligomers. In contrast with this
concentration dependent behaviour, the figure shows that the helix
content remains high and essentially independent of the
concentration in the 1-200 ?M range for the GLP-1 derivatives of
the present invention forming partially structured micelle-like
aggregates under the same conditions.
Example 105
Equilibrium Solubility
[1472] For pH-solubility profiles, solutions containing the peptide
and additives (surfactant and, where indicated, other excipients)
at the appropriate concentrations were prepared at pH 9-10. The
solutions were filtered, samples were withdrawn, and the pH was
adjusted to the desired value in the range of 3-8. The samples were
left for 24 hours at 23.degree. C. to attain solubility
equilibrium. After centrifugation (20,000 g for 20 minutes,
23.degree. C.) of each sample, the pH was measured, and the
solubility was determined from measurement of the absorbance at 276
nm of the supernatant.
[1473] Long Term Physical Stability acylated GLP-1(7-37) analogue
were dissolved at twice the desired final concentration and
incubated briefly (<10 minutes) at pH 11.5, 23.degree. C. before
filtration and mixing with an equal volume of a filtered solution
containing all the excipients in twice the desired final
concentration. The pH was then measured and adjusted as needed. The
solution was transferred to pen-fill cartridges containing a small
glass ball (to allow visual determination of changes in solution
viscosity). The containers were sealed and incubated at the desired
temperature between 4.degree. C. and 37.degree. C. At appropriate
time intervals, the samples were gently turned and visually
examined using a light box. When physical changes were apparent
(precipitation, crystallization or gelation), the sample was
centrifuged and the absorbance was measured in the supernatant to
determine whether the component coming out of solution was the
peptide or not.
[1474] Equilibrium solubility was determined as a function of pH
for 1 mg/ml solutions of the acylated GLP-1(7-37) analogue
N.epsilon.-hexadecanoyl-.gamma.-glutamyl-Lys26,Art34-GLP-1(7-37) in
the absence of additives and in the presence of increasing amounts
of the surfactant LPCL (lauroyl lysophosphatidyl choline). The
results show that 1 mM and 2 mM LPCL enhance solubility relative to
the reference composition, while full solubility is obtained in the
presence of 5 mM LPCL.
Sequence CWU 1
1
96 1 31 PRT Artificial Sequence Chemically Synthesized 1 His Ala
Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15
Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly 20 25
30 2 31 PRT Artificial Sequence Chemically Synthesized 2 His Ala
Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 20 25
30 3 31 PRT Artificial Sequence Chemically Synthesized 3 His Ala
Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15
Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Lys Gly 20 25
30 4 31 PRT Artificial Sequence Chemically Synthesized 4 His Ala
Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15
Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Lys Gly 20 25
30 5 32 PRT Artificial Sequence Chemically Synthesized 5 His Ala
Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15
Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Lys Gly Arg 20
25 30 6 33 PRT Artificial Sequence Chemically Synthesized 6 His Ala
Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15
Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Arg 20
25 30 Lys 7 34 PRT Artificial Sequence Chemically Synthesized 7 His
Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10
15 Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Arg
20 25 30 Arg Lys 8 31 PRT Artificial Sequence Chemically
Synthesized 8 His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr
Leu Glu Gly 1 5 10 15 Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val
Lys Gly Lys Gly 20 25 30 9 31 PRT Artificial Sequence Chemically
Synthesized 9 His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr
Leu Glu Gly 1 5 10 15 Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val
Arg Gly Lys Gly 20 25 30 10 33 PRT Artificial Sequence Chemically
Synthesized 10 His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr
Leu Glu Gly 1 5 10 15 Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val
Lys Gly Arg Gly Arg 20 25 30 Lys 11 34 PRT Artificial Sequence
Chemically Synthesized 11 His Ala Glu Gly Thr Phe Thr Ser Asp Val
Ser Ser Tyr Leu Glu Gly 1 5 10 15 Gln Ala Ala Lys Glu Phe Ile Ala
Trp Leu Val Arg Gly Arg Gly Arg 20 25 30 Arg Lys 12 33 PRT
Artificial Sequence Chemically Synthesized 12 His Ala Glu Gly Thr
Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15 Gln Ala Ala
Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Lys Gly Arg 20 25 30 Lys 13
34 PRT Artificial Sequence Chemically Synthesized 13 His Ala Glu
Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15 Gln
Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Lys Gly Arg 20 25
30 Arg Lys 14 31 PRT Artificial Sequence Chemically Synthesized 14
His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5
10 15 Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly
20 25 30 15 31 PRT Artificial Sequence Chemically Synthesized 15
His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5
10 15 Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly
20 25 30 16 31 PRT Artificial Sequence Chemically Synthesized 16
His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5
10 15 Gln Ala Ala Lys Glu Phe Ile Ala Trp Leu Val Lys Gly Lys Gly
20 25 30 17 31 PRT Artificial Sequence Chemically Synthesized 17
His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5
10 15 Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Lys Gly
20 25 30 18 33 PRT Artificial Sequence Chemically Synthesized 18
His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5
10 15 Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly
Arg 20 25 30 Lys 19 34 PRT Artificial Sequence Chemically
Synthesized 19 His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr
Leu Glu Gly 1 5 10 15 Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val
Arg Gly Arg Gly Arg 20 25 30 Arg Lys 20 31 PRT Artificial Sequence
Chemically Synthesized 20 His Gly Glu Gly Thr Phe Thr Ser Asp Val
Ser Ser Tyr Leu Glu Gly 1 5 10 15 Gln Ala Ala Arg Glu Phe Ile Ala
Trp Leu Val Lys Gly Lys Gly 20 25 30 21 31 PRT Artificial Sequence
Chemically Synthesized 21 His Gly Glu Gly Thr Phe Thr Ser Asp Val
Ser Ser Tyr Leu Glu Gly 1 5 10 15 Gln Ala Ala Lys Glu Phe Ile Ala
Trp Leu Val Arg Gly Lys Gly 20 25 30 22 33 PRT Artificial Sequence
Chemically Synthesized 22 His Gly Glu Gly Thr Phe Thr Ser Asp Val
Ser Ser Tyr Leu Glu Gly 1 5 10 15 Gln Ala Ala Arg Glu Phe Ile Ala
Trp Leu Val Lys Gly Arg Gly Arg 20 25 30 Lys 23 34 PRT Artificial
Sequence Chemically Synthesized 23 His Gly Glu Gly Thr Phe Thr Ser
Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15 Gln Ala Ala Lys Glu Phe
Ile Ala Trp Leu Val Arg Gly Arg Gly Arg 20 25 30 Arg Lys 24 33 PRT
Artificial Sequence Chemically Synthesized 24 His Gly Glu Gly Thr
Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15 Gln Ala Ala
Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Lys Gly Arg 20 25 30 Lys 25
34 PRT Artificial Sequence Chemically Synthesized 25 His Gly Glu
Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15 Gln
Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Lys Gly Arg 20 25
30 Arg Lys 26 32 PRT Artificial Sequence Chemically Synthesized 26
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5
10 15 Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly
Lys 20 25 30 27 33 PRT Artificial Sequence Chemically Synthesized
27 His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
1 5 10 15 Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg
Gly Arg 20 25 30 Lys 28 34 PRT Artificial Sequence Chemically
Synthesized 28 His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr
Leu Glu Gly 1 5 10 15 Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val
Arg Gly Arg Gly Arg 20 25 30 Arg Lys 29 35 PRT Artificial Sequence
Chemically Synthesized 29 His Ala Glu Gly Thr Phe Thr Ser Asp Val
Ser Ser Tyr Leu Glu Gly 1 5 10 15 Gln Ala Ala Arg Glu Phe Ile Ala
Trp Leu Val Arg Gly Arg Gly Arg 20 25 30 Arg Glu Lys 35 30 36 PRT
Artificial Sequence Chemically Synthesized 30 His Ala Glu Gly Thr
Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15 Gln Ala Ala
Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Arg 20 25 30 Arg
Glu Phe Lys 35 31 37 PRT Artificial Sequence Chemically Synthesized
31 His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly
1 5 10 15 Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg
Gly Arg 20 25 30 Arg Glu Phe Pro Lys 35 32 38 PRT Artificial
Sequence Chemically Synthesized 32 His Ala Glu Gly Thr Phe Thr Ser
Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15 Gln Ala Ala Arg Glu Phe
Ile Ala Trp Leu Val Arg Gly Arg Gly Arg 20 25 30 Arg Glu Phe Pro
Glu Lys 35 33 39 PRT Artificial Sequence Chemically Synthesized 33
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5
10 15 Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly
Arg 20 25 30 Arg Glu Phe Pro Glu Glu Lys 35 34 38 PRT Artificial
Sequence Chemically Synthesized 34 His Asp Glu Phe Glu Arg His Ala
Glu Gly Thr Phe Thr Ser Asp Val 1 5 10 15 Ser Ser Tyr Leu Glu Gly
Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu 20 25 30 Val Arg Gly Arg
Gly Lys 35 35 39 PRT Artificial Sequence Chemically Synthesized 35
His Asp Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val 1 5
10 15 Ser Ser Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp
Leu 20 25 30 Val Arg Gly Arg Gly Arg Lys 35 36 40 PRT Artificial
Sequence Chemically Synthesized 36 His Asp Glu Phe Glu Arg His Ala
Glu Gly Thr Phe Thr Ser Asp Val 1 5 10 15 Ser Ser Tyr Leu Glu Gly
Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu 20 25 30 Val Arg Gly Arg
Gly Arg Arg Lys 35 40 37 41 PRT Artificial Sequence Chemically
Synthesized 37 His Asp Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr
Ser Asp Val 1 5 10 15 Ser Ser Tyr Leu Glu Gly Gln Ala Ala Arg Glu
Phe Ile Ala Trp Leu 20 25 30 Val Arg Gly Arg Gly Arg Arg Glu Lys 35
40 38 42 PRT Artificial Sequence Chemically Synthesized 38 His Asp
Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val 1 5 10 15
Ser Ser Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu 20
25 30 Val Arg Gly Arg Gly Arg Arg Glu Phe Lys 35 40 39 43 PRT
Artificial Sequence Chemically Synthesized 39 His Asp Glu Phe Glu
Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val 1 5 10 15 Ser Ser Tyr
Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu 20 25 30 Val
Arg Gly Arg Gly Arg Arg Glu Phe Pro Lys 35 40 40 44 PRT Artificial
Sequence Chemically Synthesized 40 His Asp Glu Phe Glu Arg His Ala
Glu Gly Thr Phe Thr Ser Asp Val 1 5 10 15 Ser Ser Tyr Leu Glu Gly
Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu 20 25 30 Val Arg Gly Arg
Gly Arg Arg Glu Phe Pro Glu Lys 35 40 41 45 PRT Artificial Sequence
Chemically Synthesized 41 His Asp Glu Phe Glu Arg His Ala Glu Gly
Thr Phe Thr Ser Asp Val 1 5 10 15 Ser Ser Tyr Leu Glu Gly Gln Ala
Ala Arg Glu Phe Ile Ala Trp Leu 20 25 30 Val Arg Gly Arg Gly Arg
Arg Glu Phe Pro Glu Glu Lys 35 40 45 42 37 PRT Artificial Sequence
Chemically Synthesized 42 Asp Glu Phe Glu Arg His Ala Glu Gly Thr
Phe Thr Ser Asp Val Ser 1 5 10 15 Ser Tyr Leu Glu Gly Gln Ala Ala
Arg Glu Phe Ile Ala Trp Leu Val 20 25 30 Arg Gly Arg Gly Lys 35 43
38 PRT Artificial Sequence Chemically Synthesized 43 Asp Glu Phe
Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser 1 5 10 15 Ser
Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val 20 25
30 Arg Gly Arg Gly Arg Lys 35 44 39 PRT Artificial Sequence
Chemically Synthesized 44 Asp Glu Phe Glu Arg His Ala Glu Gly Thr
Phe Thr Ser Asp Val Ser 1 5 10 15 Ser Tyr Leu Glu Gly Gln Ala Ala
Arg Glu Phe Ile Ala Trp Leu Val 20 25 30 Arg Gly Arg Gly Arg Arg
Lys 35 45 40 PRT Artificial Sequence Chemically Synthesized 45 Asp
Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser 1 5 10
15 Ser Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val
20 25 30 Arg Gly Arg Gly Arg Arg Glu Lys 35 40 46 41 PRT Artificial
Sequence Chemically Synthesized 46 Asp Glu Phe Glu Arg His Ala Glu
Gly Thr Phe Thr Ser Asp Val Ser 1 5 10 15 Ser Tyr Leu Glu Gly Gln
Ala Ala Arg Glu Phe Ile Ala Trp Leu Val 20 25 30 Arg Gly Arg Gly
Arg Arg Glu Phe Lys 35 40 47 42 PRT Artificial Sequence Chemically
Synthesized 47 Asp Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser
Asp Val Ser 1 5 10 15 Ser Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe
Ile Ala Trp Leu Val 20 25 30 Arg Gly Arg Gly Arg Arg Glu Phe Pro
Lys 35 40 48 43 PRT Artificial Sequence Chemically Synthesized 48
Asp Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser 1 5
10 15 Ser Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu
Val 20 25 30 Arg Gly Arg Gly Arg Arg Glu Phe Pro Glu Lys 35 40 49
44 PRT Artificial Sequence Chemically Synthesized 49 Asp Glu Phe
Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser 1 5 10 15 Ser
Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val 20 25
30 Arg Gly Arg Gly Arg Arg Glu Phe Pro Glu Glu Lys 35 40 50 36 PRT
Artificial Sequence Chemically Synthesized 50 Glu Phe Glu Arg His
Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser 1 5 10 15 Tyr Leu Glu
Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg 20 25 30 Gly
Arg Gly Lys 35 51 37 PRT Artificial Sequence Chemically Synthesized
51 Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser
1 5 10 15 Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu
Val Arg 20 25 30 Gly Arg Gly Arg Lys 35 52 38 PRT Artificial
Sequence Chemically Synthesized 52 Glu Phe Glu Arg His Ala Glu Gly
Thr Phe Thr Ser Asp Val Ser Ser 1 5 10 15 Tyr Leu Glu Gly Gln Ala
Ala Arg Glu Phe Ile Ala Trp Leu Val Arg 20 25 30 Gly Arg Gly Arg
Arg Lys 35 53 39 PRT Artificial Sequence Chemically Synthesized 53
Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser 1 5
10 15 Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val
Arg 20 25 30 Gly Arg Gly Arg Arg Glu Lys 35 54 40 PRT Artificial
Sequence Chemically Synthesized 54 Glu Phe Glu Arg His Ala Glu Gly
Thr Phe Thr Ser Asp Val Ser Ser 1 5 10 15 Tyr Leu Glu Gly Gln Ala
Ala Arg Glu Phe Ile Ala Trp Leu Val Arg 20 25 30 Gly Arg Gly Arg
Arg Glu Phe Lys 35 40 55 41 PRT Artificial Sequence Chemically
Synthesized 55 Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp
Val Ser Ser 1 5 10 15 Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile
Ala Trp Leu Val Arg 20 25 30 Gly Arg Gly Arg Arg Glu Phe Pro Lys 35
40 56 42 PRT Artificial Sequence Chemically Synthesized 56 Glu Phe
Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser 1 5 10 15
Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg 20
25
30 Gly Arg Gly Arg Arg Glu Phe Pro Glu Lys 35 40 57 43 PRT
Artificial Sequence Chemically Synthesized 57 Glu Phe Glu Arg His
Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser 1 5 10 15 Tyr Leu Glu
Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg 20 25 30 Gly
Arg Gly Arg Arg Glu Phe Pro Glu Glu Lys 35 40 58 35 PRT Artificial
Sequence Chemically Synthesized 58 Phe Glu Arg His Ala Glu Gly Thr
Phe Thr Ser Asp Val Ser Ser Tyr 1 5 10 15 Leu Glu Gly Gln Ala Ala
Arg Glu Phe Ile Ala Trp Leu Val Arg Gly 20 25 30 Arg Gly Lys 35 59
36 PRT Artificial Sequence Chemically Synthesized 59 Phe Glu Arg
His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr 1 5 10 15 Leu
Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly 20 25
30 Arg Gly Arg Lys 35 60 37 PRT Artificial Sequence Chemically
Synthesized 60 Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val
Ser Ser Tyr 1 5 10 15 Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala
Trp Leu Val Arg Gly 20 25 30 Arg Gly Arg Arg Lys 35 61 38 PRT
Artificial Sequence Chemically Synthesized 61 Phe Glu Arg His Ala
Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr 1 5 10 15 Leu Glu Gly
Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly 20 25 30 Arg
Gly Arg Arg Glu Lys 35 62 39 PRT Artificial Sequence Chemically
Synthesized 62 Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val
Ser Ser Tyr 1 5 10 15 Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala
Trp Leu Val Arg Gly 20 25 30 Arg Gly Arg Arg Glu Phe Lys 35 63 40
PRT Artificial Sequence Chemically Synthesized 63 Phe Glu Arg His
Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr 1 5 10 15 Leu Glu
Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly 20 25 30
Arg Gly Arg Arg Glu Phe Pro Lys 35 40 64 41 PRT Artificial Sequence
Chemically Synthesized 64 Phe Glu Arg His Ala Glu Gly Thr Phe Thr
Ser Asp Val Ser Ser Tyr 1 5 10 15 Leu Glu Gly Gln Ala Ala Arg Glu
Phe Ile Ala Trp Leu Val Arg Gly 20 25 30 Arg Gly Arg Arg Glu Phe
Pro Glu Lys 35 40 65 42 PRT Artificial Sequence Chemically
Synthesized 65 Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val
Ser Ser Tyr 1 5 10 15 Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala
Trp Leu Val Arg Gly 20 25 30 Arg Gly Arg Arg Glu Phe Pro Glu Glu
Lys 35 40 66 34 PRT Artificial Sequence Chemically Synthesized 66
Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu 1 5
10 15 Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly
Arg 20 25 30 Gly Lys 67 35 PRT Artificial Sequence Chemically
Synthesized 67 Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser
Ser Tyr Leu 1 5 10 15 Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp
Leu Val Arg Gly Arg 20 25 30 Gly Arg Lys 35 68 36 PRT Artificial
Sequence Chemically Synthesized 68 Glu Arg His Ala Glu Gly Thr Phe
Thr Ser Asp Val Ser Ser Tyr Leu 1 5 10 15 Glu Gly Gln Ala Ala Arg
Glu Phe Ile Ala Trp Leu Val Arg Gly Arg 20 25 30 Gly Arg Arg Lys 35
69 37 PRT Artificial Sequence Chemically Synthesized 69 Glu Arg His
Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu 1 5 10 15 Glu
Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg 20 25
30 Gly Arg Arg Glu Lys 35 70 38 PRT Artificial Sequence Chemically
Synthesized 70 Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser
Ser Tyr Leu 1 5 10 15 Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp
Leu Val Arg Gly Arg 20 25 30 Gly Arg Arg Glu Phe Lys 35 71 39 PRT
Artificial Sequence Chemically Synthesized 71 Glu Arg His Ala Glu
Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu 1 5 10 15 Glu Gly Gln
Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg 20 25 30 Gly
Arg Arg Glu Phe Pro Lys 35 72 40 PRT Artificial Sequence Chemically
Synthesized 72 Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser
Ser Tyr Leu 1 5 10 15 Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp
Leu Val Arg Gly Arg 20 25 30 Gly Arg Arg Glu Phe Pro Glu Lys 35 40
73 41 PRT Artificial Sequence Chemically Synthesized 73 Glu Arg His
Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu 1 5 10 15 Glu
Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg 20 25
30 Gly Arg Arg Glu Phe Pro Glu Glu Lys 35 40 74 33 PRT Artificial
Sequence Chemically Synthesized 74 Arg His Ala Glu Gly Thr Phe Thr
Ser Asp Val Ser Ser Tyr Leu Glu 1 5 10 15 Gly Gln Ala Ala Arg Glu
Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 20 25 30 Lys 75 34 PRT
Artificial Sequence Chemically Synthesized 75 Arg His Ala Glu Gly
Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu 1 5 10 15 Gly Gln Ala
Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 20 25 30 Arg
Lys 76 35 PRT Artificial Sequence Chemically Synthesized 76 Arg His
Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu 1 5 10 15
Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 20
25 30 Arg Arg Lys 35 77 36 PRT Artificial Sequence Chemically
Synthesized 77 Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser
Tyr Leu Glu 1 5 10 15 Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu
Val Arg Gly Arg Gly 20 25 30 Arg Arg Glu Lys 35 78 37 PRT
Artificial Sequence Chemically Synthesized 78 Arg His Ala Glu Gly
Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu 1 5 10 15 Gly Gln Ala
Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 20 25 30 Arg
Arg Glu Phe Lys 35 79 38 PRT Artificial Sequence Chemically
Synthesized 79 Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser
Tyr Leu Glu 1 5 10 15 Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu
Val Arg Gly Arg Gly 20 25 30 Arg Arg Glu Phe Pro Lys 35 80 39 PRT
Artificial Sequence Chemically Synthesized 80 Arg His Ala Glu Gly
Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu 1 5 10 15 Gly Gln Ala
Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly 20 25 30 Arg
Arg Glu Phe Pro Glu Lys 35 81 40 PRT Artificial Sequence Chemically
Synthesized 81 Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val Ser Ser
Tyr Leu Glu 1 5 10 15 Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu
Val Arg Gly Arg Gly 20 25 30 Arg Arg Glu Phe Pro Glu Glu Lys 35 40
82 38 PRT Artificial Sequence Chemically Synthesized 82 His Asp Glu
Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val 1 5 10 15 Ser
Ser Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu 20 25
30 Val Lys Gly Arg Gly Lys 35 83 38 PRT Artificial Sequence
Chemically Synthesized 83 His Asp Glu Phe Glu Arg His Ala Glu Gly
Thr Phe Thr Ser Asp Val 1 5 10 15 Ser Ser Tyr Leu Glu Gly Gln Ala
Ala Lys Glu Phe Ile Ala Trp Leu 20 25 30 Val Arg Gly Arg Gly Lys 35
84 38 PRT Artificial Sequence Chemically Synthesized 84 His Asp Glu
Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val 1 5 10 15 Ser
Ser Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu 20 25
30 Val Arg Gly Lys Gly Lys 35 85 32 PRT Artificial Sequence
Chemically Synthesized 85 His Ala Glu Gly Thr Phe Thr Ser Asp Val
Ser Ser Tyr Leu Glu Gly 1 5 10 15 Gln Ala Ala Arg Glu Phe Ile Ala
Trp Leu Val Lys Gly Arg Gly Lys 20 25 30 86 32 PRT Artificial
Sequence Chemically Synthesized 86 His Ala Glu Gly Thr Phe Thr Ser
Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15 Gln Ala Ala Lys Glu Phe
Ile Ala Trp Leu Val Arg Gly Arg Gly Lys 20 25 30 87 32 PRT
Artificial Sequence Chemically Synthesized 87 His Ala Glu Gly Thr
Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15 Gln Ala Ala
Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Lys Gly Lys 20 25 30 88 32
PRT Artificial Sequence Chemically Synthesized 88 His Ala Glu Gly
Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15 Gln Ala
Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Lys 20 25 30 89
39 PRT Artificial Sequence Chemically Synthesized 89 His Asp Glu
Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val 1 5 10 15 Ser
Ser Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu 20 25
30 Val Lys Gly Arg Gly Arg Lys 35 90 39 PRT Artificial Sequence
Chemically Synthesized 90 His Asp Glu Phe Glu Arg His Ala Glu Gly
Thr Phe Thr Ser Asp Val 1 5 10 15 Ser Ser Tyr Leu Glu Gly Gln Ala
Ala Lys Glu Phe Ile Ala Trp Leu 20 25 30 Val Arg Gly Arg Gly Arg
Lys 35 91 39 PRT Artificial Sequence Chemically Synthesized 91 His
Asp Glu Phe Glu Arg His Ala Glu Gly Thr Phe Thr Ser Asp Val 1 5 10
15 Ser Ser Tyr Leu Glu Gly Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu
20 25 30 Val Arg Gly Lys Gly Arg Lys 35 92 33 PRT Artificial
Sequence Chemically Synthesized 92 His Ala Glu Gly Thr Phe Thr Ser
Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15 Gln Ala Ala Arg Glu Phe
Ile Ala Trp Leu Val Lys Gly Arg Gly Arg 20 25 30 Lys 93 33 PRT
Artificial Sequence Chemically Synthesized 93 His Ala Glu Gly Thr
Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15 Gln Ala Ala
Lys Glu Phe Ile Ala Trp Leu Val Arg Gly Arg Gly Arg 20 25 30 Lys 94
33 PRT Artificial Sequence Chemically Synthesized 94 His Ala Glu
Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10 15 Gln
Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Lys Gly Arg 20 25
30 Lys 95 32 PRT Artificial Sequence Chemically Synthesized 95 His
Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5 10
15 Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Lys Gly Arg Gly Lys
20 25 30 96 32 PRT Artificial Sequence Chemically Synthesized 96
His Gly Glu Gly Thr Phe Thr Ser Asp Val Ser Ser Tyr Leu Glu Gly 1 5
10 15 Gln Ala Ala Arg Glu Phe Ile Ala Trp Leu Val Arg Gly Lys Gly
Lys 20 25 30
* * * * *