U.S. patent application number 11/409670 was filed with the patent office on 2006-08-17 for vaccines containing ribavirin and methods of use thereof. Invention is credited to Catharina Hultgren, Matti Sallberg.
Application Number | 20060182764 11/409670 |
Document ID | / |
Family ID | 26923020 |
Filed Date | 2006-08-17 |
United States Patent Application | 20060182764 |
Kind Code | A1 |
Sallberg; Matti ; et al. | August 17, 2006 |
The present invention relates to compositions and methods for enhancing the effect of vaccines in animals, such as domestic, sport, or pet species, and humans. More particularly, the use of Ribavirin as an adjuvant to a vaccine protocol and compositions having Ribavirin and an antigen are described.
Inventors: | Sallberg; Matti; (Alvsjo, SE) ; Hultgren; Catharina; (Stockholm, SE) |
Correspondence Address: |
KNOBBE MARTENS OLSON & BEAR LLP 2040 MAIN STREET FOURTEENTH FLOOR IRVINE CA 92614 US |
Family ID: | 26923020 |
Appl. No.: | 11/409670 |
Filed: | April 24, 2006 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
10719619 | Nov 20, 2003 | |||
11409670 | Apr 24, 2006 | |||
10104966 | Mar 22, 2002 | 6680059 | ||
10719619 | Nov 20, 2003 | |||
09705547 | Nov 3, 2000 | |||
10104966 | Mar 22, 2002 | |||
60229175 | Aug 29, 2000 | |||
Current U.S. Class: | 424/204.1 ; 514/43 |
Current CPC Class: | A61K 39/292 20130101; A61K 2039/57 20130101; A61K 39/12 20130101; C12N 2770/24222 20130101; Y02A 50/30 20180101; C12N 2730/10122 20130101; C12N 2730/10134 20130101; Y10S 977/802 20130101; A61K 2039/55511 20130101; C12N 7/00 20130101; A61K 2039/55505 20130101; C07K 14/005 20130101; A61K 38/00 20130101; A61K 2121/00 20130101; Y02A 90/10 20180101; A61K 39/39 20130101; A61K 2039/53 20130101; A61K 2123/00 20130101; C12N 2770/24221 20130101; A61K 39/00 20130101 |
Class at Publication: | 424/204.1 ; 514/043 |
International Class: | A61K 39/12 20060101 A61K039/12; A61K 31/7056 20060101 A61K031/7056 |
Sequence CWU 1
1
15 1 3011 PRT Artificial Sequence Hepatitis C virus sequence 1 Met
Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 1 5 10
15 Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30 Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val
Arg Ala 35 40 45 Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly
Arg Arg Gln Pro 50 55 60 Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg
Thr Trp Ala Gln Pro Gly 65 70 75 80 Tyr Pro Trp Pro Leu Tyr Gly Asn
Glu Gly Cys Gly Trp Ala Gly Trp 85 90 95 Leu Leu Ser Pro Arg Gly
Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 100 105 110 Arg Arg Arg Ser
Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 115 120 125 Gly Phe
Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 130 135 140
Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 145
150 155 160 Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe
Ser Ile 165 170 175 Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro
Ala Ser Ala Tyr 180 185 190 Gln Val Arg Asn Ser Ser Gly Leu Tyr His
Val Thr Asn Asp Cys Pro 195 200 205 Asn Ser Ser Val Val Tyr Glu Ala
Ala Asp Ala Ile Leu His Thr Pro 210 215 220 Gly Cys Val Pro Cys Val
Arg Glu Gly Asn Ala Ser Arg Cys Trp Val 225 230 235 240 Ala Val Thr
Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Pro Thr Thr 245 250 255 Gln
Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 260 265
270 Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly
275 280 285 Gln Leu Phe Thr Phe Ser Pro Arg His His Trp Thr Thr Gln
Asp Cys 290 295 300 Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His
Arg Met Ala Trp 305 310 315 320 Asn Met Met Met Asn Trp Ser Pro Thr
Ala Ala Leu Val Val Ala Gln 325 330 335 Leu Leu Arg Ile Pro Gln Ala
Ile Met Asp Met Ile Ala Gly Ala His 340 345 350 Trp Gly Val Leu Ala
Gly Ile Lys Tyr Phe Ser Met Val Gly Asn Trp 355 360 365 Ala Lys Val
Leu Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu 370 375 380 Thr
His Val Thr Gly Gly Asn Ala Gly Arg Thr Thr Ala Gly Leu Val 385 390
395 400 Gly Leu Leu Thr Pro Gly Ala Lys Gln Asn Ile Gln Leu Ile Asn
Thr 405 410 415 Asn Gly Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys
Asn Glu Ser 420 425 430 Leu Asn Thr Gly Trp Leu Ala Gly Leu Phe Tyr
Gln His Lys Phe Asn 435 440 445 Ser Ser Gly Cys Pro Glu Arg Leu Ala
Ser Cys Arg Arg Leu Thr Asp 450 455 460 Phe Ala Gln Gly Trp Gly Pro
Ile Ser Tyr Ala Asn Gly Ser Gly Leu 465 470 475 480 Asp Glu Arg Pro
Tyr Cys Trp His Tyr Pro Pro Arg Pro Cys Gly Ile 485 490 495 Val Pro
Ala Lys Ser Val Cys Gly Pro Val Tyr Cys Phe Thr Pro Ser 500 505 510
Pro Val Val Val Gly Thr Thr Asp Arg Ser Gly Ala Pro Thr Tyr Ser 515
520 525 Trp Gly Ala Asn Asp Thr Asp Val Phe Val Leu Asn Asn Thr Arg
Pro 530 535 540 Pro Leu Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser
Thr Gly Phe 545 550 555 560 Thr Lys Val Cys Gly Ala Pro Pro Cys Val
Ile Gly Gly Val Gly Asn 565 570 575 Asn Thr Leu Leu Cys Pro Thr Asp
Cys Phe Arg Lys Tyr Pro Glu Ala 580 585 590 Thr Tyr Ser Arg Cys Gly
Ser Gly Pro Arg Ile Thr Pro Arg Cys Met 595 600 605 Val Asp Tyr Pro
Tyr Arg Leu Trp His Tyr Pro Cys Thr Ile Asn Tyr 610 615 620 Thr Ile
Phe Lys Val Arg Met Tyr Val Gly Gly Val Glu His Arg Leu 625 630 635
640 Glu Ala Ala Cys Asn Trp Thr Arg Gly Glu Arg Cys Asp Leu Glu Asp
645 650 655 Arg Asp Arg Ser Glu Leu Ser Pro Leu Leu Leu Ser Thr Thr
Gln Trp 660 665 670 Gln Val Leu Pro Cys Ser Phe Thr Thr Leu Pro Ala
Leu Ser Thr Gly 675 680 685 Leu Ile His Leu His Gln Asn Ile Val Asp
Val Gln Tyr Leu Tyr Gly 690 695 700 Val Gly Ser Ser Ile Ala Ser Trp
Ala Ile Lys Trp Glu Tyr Val Val 705 710 715 720 Leu Leu Phe Leu Leu
Leu Ala Asp Ala Arg Val Cys Ser Cys Leu Trp 725 730 735 Met Met Leu
Leu Ile Ser Gln Ala Glu Ala Ala Leu Glu Asn Leu Val 740 745 750 Ile
Leu Asn Ala Ala Ser Leu Ala Gly Thr His Gly Leu Val Ser Phe 755 760
765 Leu Val Phe Phe Cys Phe Ala Trp Tyr Leu Lys Gly Arg Trp Val Pro
770 775 780 Gly Ala Val Tyr Ala Leu Tyr Gly Met Trp Pro Leu Leu Leu
Leu Leu 785 790 795 800 Leu Ala Leu Pro Gln Arg Ala Tyr Ala Leu Asp
Thr Glu Val Ala Ala 805 810 815 Ser Cys Gly Gly Val Val Leu Val Gly
Leu Met Ala Leu Thr Leu Ser 820 825 830 Pro Tyr Tyr Lys Arg Tyr Ile
Ser Trp Cys Met Trp Trp Leu Gln Tyr 835 840 845 Phe Leu Thr Arg Val
Glu Ala Gln Leu His Val Trp Val Pro Pro Leu 850 855 860 Asn Val Arg
Gly Gly Arg Asp Ala Val Ile Leu Leu Thr Cys Val Val 865 870 875 880
His Pro Ala Leu Val Phe Asp Ile Thr Lys Leu Leu Leu Ala Ile Phe 885
890 895 Gly Pro Leu Trp Ile Leu Gln Ala Ser Leu Leu Lys Val Pro Tyr
Phe 900 905 910 Val Arg Val Gln Gly Leu Leu Arg Ile Cys Ala Leu Ala
Arg Lys Ile 915 920 925 Ala Gly Gly His Tyr Val Gln Met Ala Ile Ile
Lys Leu Gly Ala Leu 930 935 940 Thr Gly Thr Cys Val Tyr Asn His Leu
Ala Pro Leu Arg Asp Trp Ala 945 950 955 960 His Asn Gly Leu Arg Asp
Leu Ala Val Ala Val Glu Pro Val Val Phe 965 970 975 Ser Arg Met Glu
Thr Lys Leu Ile Thr Trp Gly Ala Asp Thr Ala Ala 980 985 990 Cys Gly
Asp Ile Ile Asn Gly Leu Pro Val Ser Ala Arg Arg Gly Gln 995 1000
1005 Glu Ile Leu Leu Gly Pro Ala Asp Gly Met Val Ser Lys Gly Trp
Arg 1010 1015 1020 Leu Leu Ala Pro Ile Thr Ala Tyr Ala Gln Gln Thr
Arg Gly Leu Leu 1025 1030 1035 1040 Gly Cys Ile Ile Thr Ser Leu Thr
Gly Arg Asp Lys Asn Gln Val Glu 1045 1050 1055 Gly Glu Val Gln Ile
Val Ser Thr Ala Thr Gln Thr Phe Leu Ala Thr 1060 1065 1070 Cys Ile
Asn Gly Val Cys Trp Thr Val Tyr His Gly Ala Gly Thr Arg 1075 1080
1085 Thr Ile Ala Ser Pro Lys Gly Pro Val Ile Gln Thr Tyr Thr Asn
Val 1090 1095 1100 Asp Gln Asp Leu Val Gly Trp Pro Ala Pro Gln Gly
Ser Arg Ser Leu 1105 1110 1115 1120 Thr Pro Cys Thr Cys Gly Ser Ser
Asp Leu Tyr Leu Val Thr Arg His 1125 1130 1135 Ala Asp Val Ile Pro
Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu 1140 1145 1150 Leu Ser
Pro Arg Pro Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro 1155 1160
1165 Leu Leu Cys Pro Thr Gly His Ala Val Gly Leu Phe Arg Ala Ala
Val 1170 1175 1180 Cys Thr Arg Gly Val Ala Lys Ala Val Asp Phe Ile
Pro Val Glu Asn 1185 1190 1195 1200 Leu Glu Thr Thr Met Arg Ser Pro
Val Phe Thr Asp Asn Ser Ser Pro 1205 1210 1215 Pro Ala Val Pro Gln
Ser Phe Gln Val Ala His Leu His Ala Pro Thr 1220 1225 1230 Gly Ser
Gly Lys Ser Thr Lys Val Pro Ala Ala Tyr Ala Ala Lys Gly 1235 1240
1245 Tyr Lys Val Leu Val Leu Asn Pro Ser Val Ala Ala Thr Leu Gly
Phe 1250 1255 1260 Gly Ala Tyr Met Ser Lys Ala His Gly Val Asp Pro
Asn Ile Arg Thr 1265 1270 1275 1280 Gly Val Arg Thr Ile Thr Thr Gly
Ser Pro Ile Thr Tyr Ser Thr Tyr 1285 1290 1295 Gly Lys Phe Leu Ala
Asp Ala Gly Cys Ser Gly Gly Ala Tyr Asp Ile 1300 1305 1310 Ile Ile
Cys Asp Glu Cys His Ser Thr Asp Ala Thr Ser Ile Ser Gly 1315 1320
1325 Ile Gly Thr Val Leu Asp Gln Ala Glu Thr Ala Gly Ala Arg Leu
Val 1330 1335 1340 Val Leu Ala Thr Ala Thr Pro Pro Gly Ser Val Thr
Val Ser His Pro 1345 1350 1355 1360 Asn Ile Glu Glu Val Ala Leu Ser
Thr Thr Gly Glu Ile Pro Phe Tyr 1365 1370 1375 Gly Lys Ala Ile Pro
Leu Glu Val Ile Lys Gly Gly Arg His Leu Ile 1380 1385 1390 Phe Cys
His Ser Lys Lys Lys Cys Asp Glu Leu Ala Ala Lys Leu Val 1395 1400
1405 Ala Leu Gly Ile Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val
Ser 1410 1415 1420 Val Ile Pro Thr Ser Gly Asp Val Val Val Val Ser
Thr Asp Ala Leu 1425 1430 1435 1440 Met Thr Gly Phe Thr Gly Asp Phe
Asp Ser Val Ile Asp Cys Asn Thr 1445 1450 1455 Cys Val Thr Gln Thr
Val Asp Phe Ser Leu Asp Pro Thr Phe Thr Ile 1460 1465 1470 Glu Thr
Thr Thr Leu Pro Gln Asp Ala Val Ser Arg Thr Gln Arg Arg 1475 1480
1485 Gly Arg Thr Gly Arg Gly Lys Pro Gly Ile Tyr Arg Phe Val Ala
Pro 1490 1495 1500 Gly Glu Arg Pro Ser Gly Met Phe Asp Ser Ser Val
Leu Cys Glu Cys 1505 1510 1515 1520 Tyr Asp Ala Gly Cys Ala Trp Tyr
Glu Leu Thr Pro Ala Glu Thr Thr 1525 1530 1535 Val Arg Leu Arg Ala
Tyr Met Asn Thr Pro Gly Leu Pro Val Cys Gln 1540 1545 1550 Asp His
Leu Gly Phe Trp Glu Gly Val Phe Thr Gly Leu Thr His Ile 1555 1560
1565 Asp Ala His Phe Leu Ser Gln Thr Lys Gln Ser Gly Glu Asn Phe
Pro 1570 1575 1580 Tyr Leu Val Ala Tyr Gln Ala Thr Val Cys Ala Arg
Ala Gln Ala Pro 1585 1590 1595 1600 Pro Pro Ser Trp Asp Gln Met Arg
Lys Cys Leu Ile Arg Leu Lys Pro 1605 1610 1615 Thr Leu His Gly Pro
Thr Pro Leu Leu Tyr Arg Leu Gly Ala Val Gln 1620 1625 1630 Asn Glu
Val Thr Leu Thr His Pro Ile Thr Lys Tyr Ile Met Thr Cys 1635 1640
1645 Met Ser Ala Asp Leu Glu Val Val Thr Ser Thr Trp Val Leu Val
Gly 1650 1655 1660 Gly Val Leu Ala Ala Leu Ala Ala Tyr Cys Leu Ser
Thr Gly Cys Val 1665 1670 1675 1680 Val Ile Val Gly Arg Ile Val Leu
Ser Gly Lys Pro Ala Ile Ile Pro 1685 1690 1695 Asp Arg Glu Val Leu
Tyr Gln Glu Phe Asp Glu Met Glu Glu Cys Ser 1700 1705 1710 Gln His
Leu Pro Tyr Ile Glu Gln Gly Met Met Leu Ala Glu Gln Phe 1715 1720
1725 Lys Gln Lys Ala Leu Gly Leu Leu Gln Thr Ala Ser Arg His Ala
Glu 1730 1735 1740 Val Ile Thr Pro Ala Val Gln Thr Asn Trp Gln Lys
Leu Glu Val Phe 1745 1750 1755 1760 Trp Ala Lys His Met Trp Asn Phe
Ile Ser Gly Ile Gln Tyr Leu Ala 1765 1770 1775 Gly Leu Ser Thr Leu
Pro Gly Asn Pro Ala Ile Ala Ser Leu Met Ala 1780 1785 1790 Phe Thr
Ala Ala Val Thr Ser Pro Leu Thr Thr Gly Gln Thr Leu Leu 1795 1800
1805 Phe Asn Ile Leu Gly Gly Trp Val Ala Ala Gln Leu Ala Ala Pro
Gly 1810 1815 1820 Ala Ala Thr Ala Phe Val Gly Ala Gly Leu Ala Gly
Ala Ala Leu Asp 1825 1830 1835 1840 Ser Val Gly Leu Gly Lys Val Leu
Val Asp Ile Leu Ala Gly Tyr Gly 1845 1850 1855 Ala Gly Val Ala Gly
Ala Leu Val Ala Phe Lys Ile Met Ser Gly Glu 1860 1865 1870 Val Pro
Ser Thr Glu Asp Leu Val Asn Leu Leu Pro Ala Ile Leu Ser 1875 1880
1885 Pro Gly Ala Leu Ala Val Gly Val Val Phe Ala Ser Ile Leu Arg
Arg 1890 1895 1900 Arg Val Gly Pro Gly Glu Gly Ala Val Gln Trp Met
Asn Arg Leu Ile 1905 1910 1915 1920 Ala Phe Ala Ser Arg Gly Asn His
Val Ser Pro Thr His Tyr Val Pro 1925 1930 1935 Glu Ser Asp Ala Ala
Ala Arg Val Thr Ala Ile Leu Ser Ser Leu Thr 1940 1945 1950 Val Thr
Gln Leu Leu Arg Arg Leu His Gln Trp Ile Ser Ser Glu Cys 1955 1960
1965 Thr Thr Pro Cys Ser Gly Ser Trp Leu Arg Asp Ile Trp Asp Trp
Ile 1970 1975 1980 Cys Glu Val Leu Ser Asp Phe Lys Thr Trp Leu Lys
Ala Lys Leu Met 1985 1990 1995 2000 Pro Gln Leu Pro Gly Ile Pro Phe
Val Ser Cys Gln Arg Gly Tyr Arg 2005 2010 2015 Gly Val Trp Arg Gly
Asp Gly Ile Met His Thr Arg Cys His Cys Gly 2020 2025 2030 Ala Glu
Ile Thr Gly His Val Lys Asn Gly Thr Met Arg Ile Val Gly 2035 2040
2045 Pro Arg Thr Cys Lys Asn Met Trp Ser Gly Thr Phe Phe Ile Asn
Ala 2050 2055 2060 Tyr Thr Thr Gly Pro Cys Thr Pro Leu Pro Ala Pro
Asn Tyr Lys Phe 2065 2070 2075 2080 Ala Leu Trp Arg Val Ser Ala Glu
Glu Tyr Val Glu Ile Arg Arg Val 2085 2090 2095 Gly Asp Phe His Tyr
Val Ser Gly Met Thr Thr Asp Asn Leu Lys Cys 2100 2105 2110 Pro Cys
Gln Ile Pro Ser Pro Glu Phe Phe Thr Glu Leu Asp Gly Val 2115 2120
2125 Arg Leu His Arg Phe Ala Pro Pro Cys Lys Pro Leu Leu Arg Glu
Glu 2130 2135 2140 Val Ser Phe Arg Val Gly Leu His Glu Tyr Pro Val
Gly Ser Gln Leu 2145 2150 2155 2160 Pro Cys Glu Pro Glu Pro Asp Val
Ala Val Leu Thr Ser Met Leu Thr 2165 2170 2175 Asp Pro Ser His Ile
Thr Ala Glu Ala Ala Gly Arg Arg Leu Ala Arg 2180 2185 2190 Gly Ser
Pro Pro Ser Met Ala Ser Ser Ser Ala Ser Gln Leu Ser Ala 2195 2200
2205 Pro Ser Leu Lys Ala Thr Cys Thr Ala Asn His Asp Ser Pro Asp
Ala 2210 2215 2220 Glu Leu Ile Glu Ala Asn Leu Leu Trp Arg Gln Glu
Met Gly Gly Asn 2225 2230 2235 2240 Ile Thr Arg Val Glu Ser Glu Asn
Lys Val Val Ile Leu Asp Ser Phe 2245 2250 2255 Asp Pro Leu Val Ala
Glu Glu Asp Glu Arg Glu Val Ser Val Pro Ala 2260 2265 2270 Glu Ile
Leu Arg Lys Ser Arg Arg Phe Ala Pro Ala Leu Pro Val Trp 2275 2280
2285 Ala Arg Pro Asp Tyr Asn Pro Leu Leu Val Glu Thr Trp Lys Lys
Pro 2290 2295 2300 Asp Tyr Glu Pro Pro Val Val His Gly Cys Pro Leu
Pro Pro Pro Arg 2305 2310 2315 2320 Ser Pro Pro Val Pro Pro Pro Arg
Lys Lys Arg Thr Val Val Leu Thr 2325 2330 2335 Glu Ser Thr Leu Pro
Thr Ala Leu Ala Glu Leu Ala Thr Lys Ser Phe 2340 2345 2350 Gly Ser
Ser Ser Thr Ser Gly Ile Thr Gly Asp Asn Thr Thr Thr Ser 2355 2360
2365 Ser Glu Pro Ala Pro Ser Gly Cys Pro Pro Asp Ser Asp Val Glu
Ser 2370 2375 2380 Tyr Ser Ser Met Pro Pro Leu Glu Gly Glu Pro Gly
Asp Pro Asp Leu 2385 2390 2395 2400 Ser Asp Gly Ser Trp Ser Thr Val
Ser Ser Gly Ala Asp Thr Glu Asp 2405 2410 2415 Val Val Cys Cys
Ser
Met Ser Tyr Ser Trp Thr Gly Ala Leu Val Thr 2420 2425 2430 Pro Cys
Ala Ala Glu Glu Gln Lys Leu Pro Ile Asn Ala Leu Ser Asn 2435 2440
2445 Ser Leu Leu Arg His His Asn Leu Val Tyr Ser Thr Thr Ser Arg
Ser 2450 2455 2460 Ala Cys Gln Arg Lys Lys Lys Val Thr Phe Asp Arg
Leu Gln Val Leu 2465 2470 2475 2480 Asp Ser His Tyr Gln Asp Val Leu
Lys Glu Val Lys Ala Ala Ala Ser 2485 2490 2495 Lys Val Lys Ala Asn
Leu Leu Ser Val Glu Glu Ala Cys Ser Leu Ala 2500 2505 2510 Pro Pro
His Ser Ala Lys Ser Lys Phe Gly Tyr Gly Ala Lys Asp Val 2515 2520
2525 Arg Cys His Ala Arg Lys Ala Val Ala His Ile Asn Ser Val Trp
Lys 2530 2535 2540 Asp Leu Leu Glu Asp Ser Val Thr Pro Ile Asp Thr
Thr Ile Met Ala 2545 2550 2555 2560 Lys Asn Glu Val Phe Cys Val Gln
Pro Glu Lys Gly Gly Arg Lys Pro 2565 2570 2575 Ala Arg Leu Ile Val
Phe Pro Asp Leu Gly Val Arg Val Cys Glu Lys 2580 2585 2590 Met Ala
Leu Tyr Asp Val Val Ser Lys Leu Pro Leu Ala Val Met Gly 2595 2600
2605 Ser Ser Tyr Gly Phe Gln Tyr Ser Pro Gly Gln Arg Val Glu Phe
Leu 2610 2615 2620 Val Gln Ala Trp Lys Ser Lys Lys Thr Pro Met Gly
Leu Ser Tyr Asp 2625 2630 2635 2640 Thr Arg Cys Phe Asp Ser Thr Val
Thr Glu Ser Asp Ile Arg Thr Glu 2645 2650 2655 Glu Ala Ile Tyr Gln
Cys Cys Asp Leu Asp Pro Gln Ala Arg Val Ala 2660 2665 2670 Ile Lys
Ser Leu Thr Glu Arg Leu Tyr Val Gly Gly Pro Leu Thr Asn 2675 2680
2685 Ser Arg Gly Glu Asn Cys Gly Tyr Arg Arg Cys Arg Ala Ser Arg
Val 2690 2695 2700 Leu Thr Thr Ser Cys Gly Asn Thr Leu Thr Arg Tyr
Ile Lys Ala Arg 2705 2710 2715 2720 Ala Ala Cys Arg Ala Ala Gly Leu
Gln Asp Cys Thr Met Leu Val Cys 2725 2730 2735 Gly Asp Asp Leu Val
Val Ile Cys Glu Ser Ala Gly Val Gln Glu Asp 2740 2745 2750 Ala Ala
Ser Leu Arg Ala Phe Thr Glu Ala Met Thr Arg Tyr Ser Ala 2755 2760
2765 Pro Pro Gly Asp Pro Pro Gln Pro Glu Tyr Asp Leu Glu Leu Ile
Thr 2770 2775 2780 Ser Cys Ser Ser Asn Val Ser Val Ala His Asp Gly
Ala Gly Lys Arg 2785 2790 2795 2800 Val Tyr Tyr Leu Thr Arg Asp Pro
Thr Thr Pro Leu Ala Arg Ala Ala 2805 2810 2815 Trp Glu Thr Ala Arg
His Thr Pro Val Asn Ser Trp Leu Gly Asn Ile 2820 2825 2830 Ile Met
Phe Ala Pro Thr Leu Trp Ala Arg Met Ile Leu Met Thr His 2835 2840
2845 Phe Phe Ser Val Leu Ile Ala Arg Asp Gln Leu Glu Gln Ala Leu
Asn 2850 2855 2860 Cys Glu Ile Tyr Gly Ala Cys Tyr Ser Ile Glu Pro
Leu Asp Leu Pro 2865 2870 2875 2880 Pro Ile Ile Gln Arg Leu His Gly
Leu Ser Ala Phe Ser Leu His Ser 2885 2890 2895 Tyr Ser Pro Gly Glu
Ile Asn Arg Val Ala Ala Cys Leu Arg Lys Leu 2900 2905 2910 Gly Val
Pro Pro Leu Arg Ala Trp Arg His Arg Ala Trp Ser Val Arg 2915 2920
2925 Ala Arg Leu Leu Ala Arg Gly Gly Lys Ala Ala Ile Cys Gly Lys
Tyr 2930 2935 2940 Leu Phe Asn Trp Ala Val Arg Thr Lys Leu Lys Leu
Thr Pro Ile Thr 2945 2950 2955 2960 Ala Ala Gly Arg Leu Asp Leu Ser
Gly Trp Phe Thr Ala Gly Tyr Ser 2965 2970 2975 Gly Gly Asp Ile Tyr
His Ser Val Ser His Ala Arg Pro Arg Trp Phe 2980 2985 2990 Trp Phe
Cys Leu Leu Leu Leu Ala Ala Gly Val Gly Ile Tyr Leu Leu 2995 3000
3005 Pro Asn Arg 3010 3 197 PRT Artificial Sequence Hepatitis C
virus E1 protein sequence 3 Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr
Gln Val Arg Asn Ser Ser 1 5 10 15 Gly Leu Tyr His Val Thr Asn Asp
Cys Pro Asn Ser Ser Val Val Tyr 20 25 30 Glu Ala Ala Asp Ala Ile
Leu His Thr Pro Gly Cys Val Pro Cys Val 35 40 45 Arg Glu Gly Asn
Ala Ser Arg Cys Trp Val Ala Val Thr Pro Thr Val 50 55 60 Ala Thr
Arg Asp Gly Lys Leu Pro Thr Thr Gln Leu Arg Arg His Ile 65 70 75 80
Asp Leu Leu Val Gly Ser Ala Thr Leu Cys Ser Ala Leu Tyr Val Gly 85
90 95 Asp Leu Cys Gly Ser Val Phe Leu Val Gly Gln Leu Phe Thr Phe
Ser 100 105 110 Pro Arg His His Trp Thr Thr Gln Asp Cys Asn Cys Ser
Ile Tyr Pro 115 120 125 Gly His Ile Thr Gly His Arg Met Ala Trp Asn
Met Met Met Asn Trp 130 135 140 Ser Pro Thr Ala Ala Leu Val Val Ala
Gln Leu Leu Arg Ile Pro Gln 145 150 155 160 Ala Ile Met Asp Met Ile
Ala Gly Ala His Trp Gly Val Leu Ala Gly 165 170 175 Ile Lys Tyr Phe
Ser Met Val Gly Asn Trp Ala Lys Val Leu Val Val 180 185 190 Leu Leu
Leu Phe Ala 195 4 350 PRT Artificial Sequence Hepatitis C virus E2
protein sequence 4 Gly Val Asp Ala Glu Thr His Val Thr Gly Gly Asn
Ala Gly Arg Thr 1 5 10 15 Thr Ala Gly Leu Val Gly Leu Leu Thr Pro
Gly Ala Lys Gln Asn Ile 20 25 30 Gln Leu Ile Asn Thr Asn Gly Ser
Trp His Ile Asn Ser Thr Ala Leu 35 40 45 Asn Cys Asn Glu Ser Leu
Asn Thr Gly Trp Leu Ala Gly Leu Phe Tyr 50 55 60 Gln His Lys Phe
Asn Ser Ser Gly Cys Pro Glu Arg Leu Ala Ser Cys 65 70 75 80 Arg Arg
Leu Thr Asp Phe Ala Gln Gly Trp Gly Pro Ile Ser Tyr Ala 85 90 95
Asn Gly Ser Gly Leu Asp Glu Arg Pro Tyr Cys Trp His Tyr Pro Pro 100
105 110 Arg Pro Cys Gly Ile Val Pro Ala Lys Ser Val Cys Gly Pro Val
Tyr 115 120 125 Cys Phe Thr Pro Ser Pro Val Val Val Gly Thr Thr Asp
Arg Ser Gly 130 135 140 Ala Pro Thr Tyr Ser Trp Gly Ala Asn Asp Thr
Asp Val Phe Val Leu 145 150 155 160 Asn Asn Thr Arg Pro Pro Leu Gly
Asn Trp Phe Gly Cys Thr Trp Met 165 170 175 Asn Ser Thr Gly Phe Thr
Lys Val Cys Gly Ala Pro Pro Cys Val Ile 180 185 190 Gly Gly Val Gly
Asn Asn Thr Leu Leu Cys Pro Thr Asp Cys Phe Arg 195 200 205 Lys Tyr
Pro Glu Ala Thr Tyr Ser Arg Cys Gly Ser Gly Pro Arg Ile 210 215 220
Thr Pro Arg Cys Met Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr Pro 225
230 235 240 Cys Thr Ile Asn Tyr Thr Ile Phe Lys Val Arg Met Tyr Val
Gly Gly 245 250 255 Val Glu His Arg Leu Glu Ala Ala Cys Asn Trp Thr
Arg Gly Glu Arg 260 265 270 Cys Asp Leu Glu Asp Arg Asp Arg Ser Glu
Leu Ser Pro Leu Leu Leu 275 280 285 Ser Thr Thr Gln Trp Gln Val Leu
Pro Cys Ser Phe Thr Thr Leu Pro 290 295 300 Ala Leu Ser Thr Gly Leu
Ile His Leu His Gln Asn Ile Val Asp Val 305 310 315 320 Gln Tyr Leu
Tyr Gly Val Gly Ser Ser Ile Ala Ser Trp Ala Ile Lys 325 330 335 Trp
Glu Tyr Val Val Leu Leu Phe Leu Leu Leu Ala Asp Ala 340 345 350 5
315 PRT Artificial Sequence Hepatitis C virus NS2 protein sequence
5 Arg Val Cys Ser Cys Leu Trp Met Met Leu Leu Ile Ser Gln Ala Glu 1
5 10 15 Ala Ala Leu Glu Asn Leu Val Ile Leu Asn Ala Ala Ser Leu Ala
Gly 20 25 30 Thr His Gly Leu Val Ser Phe Leu Val Phe Phe Cys Phe
Ala Trp Tyr 35 40 45 Leu Lys Gly Arg Trp Val Pro Gly Ala Val Tyr
Ala Leu Tyr Gly Met 50 55 60 Trp Pro Leu Leu Leu Leu Leu Leu Ala
Leu Pro Gln Arg Ala Tyr Ala 65 70 75 80 Leu Asp Thr Glu Val Ala Ala
Ser Cys Gly Gly Val Val Leu Val Gly 85 90 95 Leu Met Ala Leu Thr
Leu Ser Pro Tyr Tyr Lys Arg Tyr Ile Ser Trp 100 105 110 Cys Met Trp
Trp Leu Gln Tyr Phe Leu Thr Arg Val Glu Ala Gln Leu 115 120 125 His
Val Trp Val Pro Pro Leu Asn Val Arg Gly Gly Arg Asp Ala Val 130 135
140 Ile Leu Leu Thr Cys Val Val His Pro Ala Leu Val Phe Asp Ile Thr
145 150 155 160 Lys Leu Leu Leu Ala Ile Phe Gly Pro Leu Trp Ile Leu
Gln Ala Ser 165 170 175 Leu Leu Lys Val Pro Tyr Phe Val Arg Val Gln
Gly Leu Leu Arg Ile 180 185 190 Cys Ala Leu Ala Arg Lys Ile Ala Gly
Gly His Tyr Val Gln Met Ala 195 200 205 Ile Ile Lys Leu Gly Ala Leu
Thr Gly Thr Cys Val Tyr Asn His Leu 210 215 220 Ala Pro Leu Arg Asp
Trp Ala His Asn Gly Leu Arg Asp Leu Ala Val 225 230 235 240 Ala Val
Glu Pro Val Val Phe Ser Arg Met Glu Thr Lys Leu Ile Thr 245 250 255
Trp Gly Ala Asp Thr Ala Ala Cys Gly Asp Ile Ile Asn Gly Leu Pro 260
265 270 Val Ser Ala Arg Arg Gly Gln Glu Ile Leu Leu Gly Pro Ala Asp
Gly 275 280 285 Met Val Ser Lys Gly Trp Arg Leu Leu Ala Pro Ile Thr
Ala Tyr Ala 290 295 300 Gln Gln Thr Arg Gly Leu Leu Gly Cys Ile Ile
305 310 315 6 613 PRT Artificial Sequence Hepatitis C virus NS3
protein sequence 6 Thr Ser Leu Thr Gly Arg Asp Lys Asn Gln Val Glu
Gly Glu Val Gln 1 5 10 15 Ile Val Ser Thr Ala Thr Gln Thr Phe Leu
Ala Thr Cys Ile Asn Gly 20 25 30 Val Cys Trp Thr Val Tyr His Gly
Ala Gly Thr Arg Thr Ile Ala Ser 35 40 45 Pro Lys Gly Pro Val Ile
Gln Thr Tyr Thr Asn Val Asp Gln Asp Leu 50 55 60 Val Gly Trp Pro
Ala Pro Gln Gly Ser Arg Ser Leu Thr Pro Cys Thr 65 70 75 80 Cys Gly
Ser Ser Asp Leu Tyr Leu Val Thr Arg His Ala Asp Val Ile 85 90 95
Pro Val Arg Arg Arg Gly Asp Ser Arg Gly Ser Leu Leu Ser Pro Arg 100
105 110 Pro Ile Ser Tyr Leu Lys Gly Ser Ser Gly Gly Pro Leu Leu Cys
Pro 115 120 125 Thr Gly His Ala Val Gly Leu Phe Arg Ala Ala Val Cys
Thr Arg Gly 130 135 140 Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu
Asn Leu Glu Thr Thr 145 150 155 160 Met Arg Ser Pro Val Phe Thr Asp
Asn Ser Ser Pro Pro Ala Val Pro 165 170 175 Gln Ser Phe Gln Val Ala
His Leu His Ala Pro Thr Gly Ser Gly Lys 180 185 190 Ser Thr Lys Val
Pro Ala Ala Tyr Ala Ala Lys Gly Tyr Lys Val Leu 195 200 205 Val Leu
Asn Pro Ser Val Ala Ala Thr Leu Gly Phe Gly Ala Tyr Met 210 215 220
Ser Lys Ala His Gly Val Asp Pro Asn Ile Arg Thr Gly Val Arg Thr 225
230 235 240 Ile Thr Thr Gly Ser Pro Ile Thr Tyr Ser Thr Tyr Gly Lys
Phe Leu 245 250 255 Ala Asp Ala Gly Cys Ser Gly Gly Ala Tyr Asp Ile
Ile Ile Cys Asp 260 265 270 Glu Cys His Ser Thr Asp Ala Thr Ser Ile
Ser Gly Ile Gly Thr Val 275 280 285 Leu Asp Gln Ala Glu Thr Ala Gly
Ala Arg Leu Val Val Leu Ala Thr 290 295 300 Ala Thr Pro Pro Gly Ser
Val Thr Val Ser His Pro Asn Ile Glu Glu 305 310 315 320 Val Ala Leu
Ser Thr Thr Gly Glu Ile Pro Phe Tyr Gly Lys Ala Ile 325 330 335 Pro
Leu Glu Val Ile Lys Gly Gly Arg His Leu Ile Phe Cys His Ser 340 345
350 Lys Lys Lys Cys Asp Glu Leu Ala Ala Lys Leu Val Ala Leu Gly Ile
355 360 365 Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val Ile
Pro Thr 370 375 380 Ser Gly Asp Val Val Val Val Ser Thr Asp Ala Leu
Met Thr Gly Phe 385 390 395 400 Thr Gly Asp Phe Asp Ser Val Ile Asp
Cys Asn Thr Cys Val Thr Gln 405 410 415 Thr Val Asp Phe Ser Leu Asp
Pro Thr Phe Thr Ile Glu Thr Thr Thr 420 425 430 Leu Pro Gln Asp Ala
Val Ser Arg Thr Gln Arg Arg Gly Arg Thr Gly 435 440 445 Arg Gly Lys
Pro Gly Ile Tyr Arg Phe Val Ala Pro Gly Glu Arg Pro 450 455 460 Ser
Gly Met Phe Asp Ser Ser Val Leu Cys Glu Cys Tyr Asp Ala Gly 465 470
475 480 Cys Ala Trp Tyr Glu Leu Thr Pro Ala Glu Thr Thr Val Arg Leu
Arg 485 490 495 Ala Tyr Met Asn Thr Pro Gly Leu Pro Val Cys Gln Asp
His Leu Gly 500 505 510 Phe Trp Glu Gly Val Phe Thr Gly Leu Thr His
Ile Asp Ala His Phe 515 520 525 Leu Ser Gln Thr Lys Gln Ser Gly Glu
Asn Phe Pro Tyr Leu Val Ala 530 535 540 Tyr Gln Ala Thr Val Cys Ala
Arg Ala Gln Ala Pro Pro Pro Ser Trp 545 550 555 560 Asp Gln Met Arg
Lys Cys Leu Ile Arg Leu Lys Pro Thr Leu His Gly 565 570 575 Pro Thr
Pro Leu Leu Tyr Arg Leu Gly Ala Val Gln Asn Glu Val Thr 580 585 590
Leu Thr His Pro Ile Thr Lys Tyr Ile Met Thr Cys Met Ser Ala Asp 595
600 605 Leu Glu Val Val Thr 610 7 54 PRT Artificial Sequence
Hepatitis C virus NS4A protein sequence 7 Ser Thr Trp Val Leu Val
Gly Gly Val Leu Ala Ala Leu Ala Ala Tyr 1 5 10 15 Cys Leu Ser Thr
Gly Cys Val Val Ile Val Gly Arg Ile Val Leu Ser 20 25 30 Gly Lys
Pro Ala Ile Ile Pro Asp Arg Glu Val Leu Tyr Gln Glu Phe 35 40 45
Asp Glu Met Glu Glu Cys 50 8 260 PRT Artificial Sequence Hepatitis
C virus NS4B protein sequence 8 Ser Gln His Leu Pro Tyr Ile Glu Gln
Gly Met Met Leu Ala Glu Gln 1 5 10 15 Phe Lys Gln Lys Ala Leu Gly
Leu Leu Gln Thr Ala Ser Arg His Ala 20 25 30 Glu Val Ile Thr Pro
Ala Val Gln Thr Asn Trp Gln Lys Leu Glu Val 35 40 45 Phe Trp Ala
Lys His Met Trp Asn Phe Ile Ser Gly Ile Gln Tyr Leu 50 55 60 Ala
Gly Leu Ser Thr Leu Pro Gly Asn Pro Ala Ile Ala Ser Leu Met 65 70
75 80 Ala Phe Thr Ala Ala Val Thr Ser Pro Leu Thr Thr Gly Gln Thr
Leu 85 90 95 Leu Phe Asn Ile Leu Gly Gly Trp Val Ala Ala Gln Leu
Ala Ala Pro 100 105 110 Gly Ala Ala Thr Ala Phe Val Gly Ala Gly Leu
Ala Gly Ala Ala Leu 115 120 125 Asp Ser Val Gly Leu Gly Lys Val Leu
Val Asp Ile Leu Ala Gly Tyr 130 135 140 Gly Ala Gly Val Ala Gly Ala
Leu Val Ala Phe Lys Ile Met Ser Gly 145 150 155 160 Glu Val Pro Ser
Thr Glu Asp Leu Val Asn Leu Leu Pro Ala Ile Leu 165 170 175 Ser Pro
Gly Ala Leu Ala Val Gly Val Val Phe Ala Ser Ile Leu Arg 180 185 190
Arg Arg Val Gly Pro Gly Glu Gly Ala Val Gln Trp Met Asn Arg Leu 195
200 205 Ile Ala Phe Ala Ser Arg Gly Asn His Val Ser Pro Thr His Tyr
Val 210 215 220 Pro Glu Ser Asp Ala Ala Ala Arg Val Thr Ala Ile Leu
Ser Ser Leu 225 230 235 240 Thr Val Thr Gln Leu Leu Arg Arg Leu His
Gln Trp Ile Ser Ser Glu 245 250 255 Cys Thr Thr Pro 260 9 1040 PRT
Artificial Sequence
Hepatitis C virus NS5A/B protein sequence 9 Cys Ser Gly Ser Trp Leu
Arg Asp Ile Trp Asp Trp Ile Cys Glu Val 1 5 10 15 Leu Ser Asp Phe
Lys Thr Trp Leu Lys Ala Lys Leu Met Pro Gln Leu 20 25 30 Pro Gly
Ile Pro Phe Val Ser Cys Gln Arg Gly Tyr Arg Gly Val Trp 35 40 45
Arg Gly Asp Gly Ile Met His Thr Arg Cys His Cys Gly Ala Glu Ile 50
55 60 Thr Gly His Val Lys Asn Gly Thr Met Arg Ile Val Gly Pro Arg
Thr 65 70 75 80 Cys Lys Asn Met Trp Ser Gly Thr Phe Phe Ile Asn Ala
Tyr Thr Thr 85 90 95 Gly Pro Cys Thr Pro Leu Pro Ala Pro Asn Tyr
Lys Phe Ala Leu Trp 100 105 110 Arg Val Ser Ala Glu Glu Tyr Val Glu
Ile Arg Arg Val Gly Asp Phe 115 120 125 His Tyr Val Ser Gly Met Thr
Thr Asp Asn Leu Lys Cys Pro Cys Gln 130 135 140 Ile Pro Ser Pro Glu
Phe Phe Thr Glu Leu Asp Gly Val Arg Leu His 145 150 155 160 Arg Phe
Ala Pro Pro Cys Lys Pro Leu Leu Arg Glu Glu Val Ser Phe 165 170 175
Arg Val Gly Leu His Glu Tyr Pro Val Gly Ser Gln Leu Pro Cys Glu 180
185 190 Pro Glu Pro Asp Val Ala Val Leu Thr Ser Met Leu Thr Asp Pro
Ser 195 200 205 His Ile Thr Ala Glu Ala Ala Gly Arg Arg Leu Ala Arg
Gly Ser Pro 210 215 220 Pro Ser Met Ala Ser Ser Ser Ala Ser Gln Leu
Ser Ala Pro Ser Leu 225 230 235 240 Lys Ala Thr Cys Thr Ala Asn His
Asp Ser Pro Asp Ala Glu Leu Ile 245 250 255 Glu Ala Asn Leu Leu Trp
Arg Gln Glu Met Gly Gly Asn Ile Thr Arg 260 265 270 Val Glu Ser Glu
Asn Lys Val Val Ile Leu Asp Ser Phe Asp Pro Leu 275 280 285 Val Ala
Glu Glu Asp Glu Arg Glu Val Ser Val Pro Ala Glu Ile Leu 290 295 300
Arg Lys Ser Arg Arg Phe Ala Pro Ala Leu Pro Val Trp Ala Arg Pro 305
310 315 320 Asp Tyr Asn Pro Leu Leu Val Glu Thr Trp Lys Lys Pro Asp
Tyr Glu 325 330 335 Pro Pro Val Val His Gly Cys Pro Leu Pro Pro Pro
Arg Ser Pro Pro 340 345 350 Val Pro Pro Pro Arg Lys Lys Arg Thr Val
Val Leu Thr Glu Ser Thr 355 360 365 Leu Pro Thr Ala Leu Ala Glu Leu
Ala Thr Lys Ser Phe Gly Ser Ser 370 375 380 Ser Thr Ser Gly Ile Thr
Gly Asp Asn Thr Thr Thr Ser Ser Glu Pro 385 390 395 400 Ala Pro Ser
Gly Cys Pro Pro Asp Ser Asp Val Glu Ser Tyr Ser Ser 405 410 415 Met
Pro Pro Leu Glu Gly Glu Pro Gly Asp Pro Asp Leu Ser Asp Gly 420 425
430 Ser Trp Ser Thr Val Ser Ser Gly Ala Asp Thr Glu Asp Val Val Cys
435 440 445 Cys Ser Met Ser Tyr Ser Trp Thr Gly Ala Leu Val Thr Pro
Cys Ala 450 455 460 Ala Glu Glu Gln Lys Leu Pro Ile Asn Ala Leu Ser
Asn Ser Leu Leu 465 470 475 480 Arg His His Asn Leu Val Tyr Ser Thr
Thr Ser Arg Ser Ala Cys Gln 485 490 495 Arg Lys Lys Lys Val Thr Phe
Asp Arg Leu Gln Val Leu Asp Ser His 500 505 510 Tyr Gln Asp Val Leu
Lys Glu Val Lys Ala Ala Ala Ser Lys Val Lys 515 520 525 Ala Asn Leu
Leu Ser Val Glu Glu Ala Cys Ser Leu Ala Pro Pro His 530 535 540 Ser
Ala Lys Ser Lys Phe Gly Tyr Gly Ala Lys Asp Val Arg Cys His 545 550
555 560 Ala Arg Lys Ala Val Ala His Ile Asn Ser Val Trp Lys Asp Leu
Leu 565 570 575 Glu Asp Ser Val Thr Pro Ile Asp Thr Thr Ile Met Ala
Lys Asn Glu 580 585 590 Val Phe Cys Val Gln Pro Glu Lys Gly Gly Arg
Lys Pro Ala Arg Leu 595 600 605 Ile Val Phe Pro Asp Leu Gly Val Arg
Val Cys Glu Lys Met Ala Leu 610 615 620 Tyr Asp Val Val Ser Lys Leu
Pro Leu Ala Val Met Gly Ser Ser Tyr 625 630 635 640 Gly Phe Gln Tyr
Ser Pro Gly Gln Arg Val Glu Phe Leu Val Gln Ala 645 650 655 Trp Lys
Ser Lys Lys Thr Pro Met Gly Leu Ser Tyr Asp Thr Arg Cys 660 665 670
Phe Asp Ser Thr Val Thr Glu Ser Asp Ile Arg Thr Glu Glu Ala Ile 675
680 685 Tyr Gln Cys Cys Asp Leu Asp Pro Gln Ala Arg Val Ala Ile Lys
Ser 690 695 700 Leu Thr Glu Arg Leu Tyr Val Gly Gly Pro Leu Thr Asn
Ser Arg Gly 705 710 715 720 Glu Asn Cys Gly Tyr Arg Arg Cys Arg Ala
Ser Arg Val Leu Thr Thr 725 730 735 Ser Cys Gly Asn Thr Leu Thr Arg
Tyr Ile Lys Ala Arg Ala Ala Cys 740 745 750 Arg Ala Ala Gly Leu Gln
Asp Cys Thr Met Leu Val Cys Gly Asp Asp 755 760 765 Leu Val Val Ile
Cys Glu Ser Ala Gly Val Gln Glu Asp Ala Ala Ser 770 775 780 Leu Arg
Ala Phe Thr Glu Ala Met Thr Arg Tyr Ser Ala Pro Pro Gly 785 790 795
800 Asp Pro Pro Gln Pro Glu Tyr Asp Leu Glu Leu Ile Thr Ser Cys Ser
805 810 815 Ser Asn Val Ser Val Ala His Asp Gly Ala Gly Lys Arg Val
Tyr Tyr 820 825 830 Leu Thr Arg Asp Pro Thr Thr Pro Leu Ala Arg Ala
Ala Trp Glu Thr 835 840 845 Ala Arg His Thr Pro Val Asn Ser Trp Leu
Gly Asn Ile Ile Met Phe 850 855 860 Ala Pro Thr Leu Trp Ala Arg Met
Ile Leu Met Thr His Phe Phe Ser 865 870 875 880 Val Leu Ile Ala Arg
Asp Gln Leu Glu Gln Ala Leu Asn Cys Glu Ile 885 890 895 Tyr Gly Ala
Cys Tyr Ser Ile Glu Pro Leu Asp Leu Pro Pro Ile Ile 900 905 910 Gln
Arg Leu His Gly Leu Ser Ala Phe Ser Leu His Ser Tyr Ser Pro 915 920
925 Gly Glu Ile Asn Arg Val Ala Ala Cys Leu Arg Lys Leu Gly Val Pro
930 935 940 Pro Leu Arg Ala Trp Arg His Arg Ala Trp Ser Val Arg Ala
Arg Leu 945 950 955 960 Leu Ala Arg Gly Gly Lys Ala Ala Ile Cys Gly
Lys Tyr Leu Phe Asn 965 970 975 Trp Ala Val Arg Thr Lys Leu Lys Leu
Thr Pro Ile Thr Ala Ala Gly 980 985 990 Arg Leu Asp Leu Ser Gly Trp
Phe Thr Ala Gly Tyr Ser Gly Gly Asp 995 1000 1005 Ile Tyr His Ser
Val Ser His Ala Arg Pro Arg Trp Phe Trp Phe Cys 1010 1015 1020 Leu
Leu Leu Leu Ala Ala Gly Val Gly Ile Tyr Leu Leu Pro Asn Arg 1025
1030 1035 1040 10 226 PRT Artificial Sequence Hepatitis B virus S
antigen (HBsAg) sequence 10 Met Glu Asn Ile Thr Ser Gly Phe Leu Gly
Pro Leu Leu Val Leu Gln 1 5 10 15 Ala Gly Phe Phe Leu Leu Thr Arg
Ile Leu Thr Ile Pro Gln Ser Leu 20 25 30 Asp Ser Trp Trp Thr Ser
Leu Asn Phe Leu Gly Gly Thr Thr Val Cys 35 40 45 Leu Gly Gln Asn
Ser Gln Ser Pro Thr Ser Asn His Ser Pro Thr Ser 50 55 60 Cys Pro
Pro Thr Cys Pro Gly Tyr Arg Trp Met Cys Leu Arg Arg Phe 65 70 75 80
Ile Ile Phe Leu Phe Ile Leu Leu Leu Cys Leu Ile Phe Leu Leu Val 85
90 95 Leu Leu Asp Tyr Gln Gly Met Leu Pro Val Cys Pro Leu Ile Pro
Gly 100 105 110 Ser Ser Thr Thr Ser Thr Gly Pro Cys Arg Thr Cys Met
Thr Thr Ala 115 120 125 Gln Gly Thr Ser Met Tyr Pro Ser Cys Cys Cys
Thr Lys Pro Ser Asp 130 135 140 Gly Asn Cys Thr Cys Ile Pro Ile Pro
Ser Ser Trp Ala Phe Gly Lys 145 150 155 160 Phe Leu Trp Glu Trp Ala
Ser Ala Arg Phe Ser Trp Leu Ser Leu Leu 165 170 175 Val Pro Phe Val
Gln Trp Phe Val Gly Leu Ser Pro Thr Val Trp Leu 180 185 190 Ser Val
Ile Trp Met Met Trp Tyr Trp Gly Pro Ser Leu Tyr Ser Ile 195 200 205
Leu Ser Pro Phe Leu Pro Leu Leu Pro Ile Phe Phe Cys Leu Trp Val 210
215 220 Tyr Ile 225 11 212 PRT Artificial Sequence Hepatitis B
virus C antigen and e antigen (HBcAg/HBeAg) sequence 11 Met Gln Leu
Phe His Leu Cys Leu Ile Ile Ser Cys Ser Cys Pro Thr 1 5 10 15 Val
Gln Ala Ser Lys Leu Cys Leu Gly Trp Leu Trp Gly Met Asp Ile 20 25
30 Asp Pro Tyr Lys Glu Phe Gly Ala Thr Val Glu Leu Leu Ser Phe Leu
35 40 45 Pro Ser Asp Phe Phe Pro Ser Val Arg Asp Leu Leu Asp Thr
Ala Ser 50 55 60 Ala Leu Tyr Arg Glu Ala Leu Glu Ser Pro Glu His
Cys Ser Pro His 65 70 75 80 His Thr Ala Leu Arg Gln Ala Ile Leu Cys
Trp Gly Glu Leu Met Thr 85 90 95 Leu Ala Thr Trp Val Gly Val Asn
Leu Glu Asp Pro Ala Ser Arg Asp 100 105 110 Leu Val Val Ser Tyr Val
Asn Thr Asn Met Gly Leu Lys Phe Arg Gln 115 120 125 Leu Leu Trp Phe
His Ile Ser Cys Leu Thr Phe Gly Arg Glu Thr Val 130 135 140 Ile Glu
Tyr Leu Val Ser Phe Gly Val Trp Ile Arg Thr Pro Pro Ala 145 150 155
160 Tyr Arg Pro Pro Asn Ala Pro Ile Leu Ser Thr Leu Pro Glu Thr Thr
165 170 175 Val Val Arg Arg Arg Gly Arg Ser Pro Arg Arg Arg Thr Pro
Ser Pro 180 185 190 Arg Arg Arg Arg Ser Gln Ser Pro Arg Arg Arg Arg
Ser Gln Ser Arg 195 200 205 Glu Ser Gln Cys 210 12 2227 PRT
Artificial Sequence Hepatitis A virus sequence 12 Met Asn Met Ser
Lys Gln Gly Ile Phe Gln Thr Val Gly Ser Gly Leu 1 5 10 15 Asp His
Ile Leu Ser Leu Ala Asp Ile Glu Glu Glu Gln Met Ile Gln 20 25 30
Ser Val Asp Arg Thr Ala Val Thr Gly Ala Ser Tyr Phe Thr Ser Val 35
40 45 Asp Gln Ser Ser Val His Thr Ala Glu Val Gly Ser His Gln Ile
Glu 50 55 60 Pro Leu Lys Thr Ser Val Asp Lys Pro Gly Ser Lys Lys
Thr Gln Gly 65 70 75 80 Glu Lys Phe Phe Leu Ile His Ser Ala Asp Trp
Leu Thr Thr His Ala 85 90 95 Leu Phe His Glu Val Ala Lys Leu Asp
Val Val Lys Leu Leu Tyr Asn 100 105 110 Glu Gln Phe Ala Val Gln Gly
Leu Leu Arg Tyr His Thr Tyr Ala Arg 115 120 125 Phe Gly Ile Glu Ile
Gln Val Gln Ile Asn Pro Thr Pro Phe Gln Gln 130 135 140 Gly Gly Leu
Ile Cys Ala Met Val Pro Gly Asp Gln Ser Tyr Gly Ser 145 150 155 160
Ile Ala Ser Leu Thr Val Tyr Pro His Gly Leu Leu Asn Cys Asn Ile 165
170 175 Asn Asn Val Val Arg Ile Lys Val Pro Phe Ile Tyr Thr Arg Gly
Ala 180 185 190 Tyr His Phe Lys Asp Pro Gln Tyr Pro Val Trp Glu Leu
Thr Ile Arg 195 200 205 Val Trp Ser Glu Leu Asn Ile Gly Thr Gly Thr
Ser Ala Tyr Thr Ser 210 215 220 Leu Asn Val Leu Ala Arg Phe Thr Asp
Leu Glu Leu His Gly Leu Thr 225 230 235 240 Pro Leu Ser Thr Gln Met
Met Arg Asn Glu Phe Arg Val Ser Thr Thr 245 250 255 Glu Asn Val Val
Asn Leu Ser Asn Tyr Glu Asp Ala Arg Ala Lys Met 260 265 270 Ser Phe
Ala Leu Asp Gln Glu Asp Trp Lys Ser Asp Pro Ser Gln Gly 275 280 285
Gly Gly Ile Lys Ile Thr His Phe Thr Thr Trp Thr Ser Ile Pro Thr 290
295 300 Leu Ala Ala Gln Phe Pro Phe Asn Ala Ser Asp Ser Val Gly Gln
Gln 305 310 315 320 Ile Lys Val Ile Pro Val Asp Pro Tyr Phe Phe Gln
Met Thr Asn Thr 325 330 335 Asn Pro Asp Gln Lys Cys Ile Thr Ala Leu
Ala Ser Ile Cys Gln Met 340 345 350 Phe Cys Phe Trp Arg Gly Asp Leu
Val Phe Asp Phe Gln Val Phe Pro 355 360 365 Thr Lys Tyr His Ser Gly
Arg Leu Leu Phe Cys Phe Val Pro Gly Asn 370 375 380 Glu Leu Ile Asp
Val Thr Gly Ile Thr Leu Lys Gln Ala Thr Thr Ala 385 390 395 400 Pro
Cys Ala Val Met Asp Ile Thr Gly Val Gln Ser Thr Leu Arg Phe 405 410
415 Arg Val Pro Trp Ile Ser Asp Thr Pro Tyr Arg Val Asn Arg Tyr Thr
420 425 430 Lys Ser Ala His Gln Lys Gly Glu Tyr Thr Ala Ile Gly Lys
Leu Ile 435 440 445 Val Tyr Cys Tyr Asn Arg Leu Thr Ser Pro Ser Asn
Val Ala Ser His 450 455 460 Val Arg Val Asn Val Tyr Leu Ser Ala Ile
Asn Leu Glu Cys Phe Ala 465 470 475 480 Pro Leu Tyr His Ala Met Asp
Val Thr Thr Gln Val Gly Asp Asp Ser 485 490 495 Gly Gly Phe Ser Thr
Thr Val Ser Thr Glu Gln Asn Val Pro Asp Pro 500 505 510 Gln Val Gly
Ile Thr Thr Met Arg Asp Leu Lys Gly Lys Ala Asn Arg 515 520 525 Gly
Lys Met Asp Val Ser Gly Val Gln Ala Pro Arg Gly Ser Tyr Gln 530 535
540 Gln Gln Leu Asn Asp Pro Val Leu Ala Lys Lys Val Pro Glu Thr Phe
545 550 555 560 Pro Glu Leu Lys Pro Gly Glu Ser Arg His Thr Ser Asp
His Met Ser 565 570 575 Ile Tyr Lys Phe Met Gly Arg Ser His Phe Leu
Cys Thr Phe Thr Phe 580 585 590 Asn Ser Asn Asn Lys Glu Tyr Thr Phe
Pro Ile Thr Leu Ser Ser Thr 595 600 605 Ser Asn Pro Pro His Gly Leu
Pro Ser Thr Leu Arg Trp Phe Phe Asn 610 615 620 Leu Phe Gln Leu Tyr
Arg Gly Pro Leu Asp Leu Thr Ile Ile Ile Thr 625 630 635 640 Gly Ala
Thr Asp Val Asp Gly Met Ala Trp Phe Thr Pro Val Gly Leu 645 650 655
Ala Val Asp Pro Trp Val Glu Lys Glu Ser Ala Leu Ser Ile Asp Tyr 660
665 670 Lys Thr Ala Leu Gly Ala Val Arg Phe Asn Thr Arg Arg Thr Gly
Asn 675 680 685 Ile Gln Ile Arg Leu Pro Trp Tyr Ser Tyr Leu Tyr Ala
Val Ser Gly 690 695 700 Ala Leu Asp Gly Leu Gly Asp Lys Thr Asp Ser
Thr Phe Gly Leu Phe 705 710 715 720 Leu Phe Glu Ile Ala Asn Tyr Asn
His Ser Asp Glu Tyr Leu Ser Phe 725 730 735 Ser Cys Tyr Leu Ser Val
Thr Glu Gln Ser Glu Phe Tyr Phe Pro Arg 740 745 750 Ala Pro Leu Asn
Ser Asn Ala Met Leu Ser Thr Glu Ser Met Met Ser 755 760 765 Arg Ile
Ala Ala Gly Asp Leu Glu Ser Ser Val Asp Asp Pro Arg Ser 770 775 780
Glu Glu Asp Arg Arg Phe Glu Ser His Ile Glu Cys Arg Lys Pro Tyr 785
790 795 800 Lys Glu Leu Arg Leu Glu Val Gly Lys Gln Arg Leu Lys Tyr
Ala Gln 805 810 815 Glu Glu Leu Ser Asn Glu Val Leu Pro Pro Pro Arg
Lys Met Lys Gly 820 825 830 Leu Phe Ser Gln Ala Lys Ile Ser Leu Phe
Tyr Thr Glu Glu His Glu 835 840 845 Ile Met Lys Phe Ser Trp Arg Gly
Val Thr Ala Asp Thr Arg Ala Leu 850 855 860 Arg Arg Phe Gly Phe Ser
Leu Ala Ala Gly Arg Ser Val Trp Thr Leu 865 870 875 880 Glu Met Asp
Ala Gly Val Leu Thr Gly Arg Leu Ile Arg Leu Asn Asp 885 890 895 Glu
Lys Trp Thr Glu Met Lys Asp Asp Lys Ile Val Ser Leu Ile Glu 900 905
910 Lys Phe Thr Ser Asn Lys Tyr Trp Ser Lys Val Asn Phe Pro His Gly
915 920 925 Met Leu Asp Leu Glu Glu Ile
Ala Ala Asn Ser Lys Asp Phe Pro Asn 930 935 940 Met Ser Glu Thr Asp
Leu Cys Phe Leu Leu His Trp Leu Asn Pro Lys 945 950 955 960 Lys Ile
Asn Leu Ala Asp Arg Met Leu Gly Leu Ser Gly Val Gln Glu 965 970 975
Ile Lys Glu Gln Gly Val Gly Leu Ile Ala Glu Cys Arg Thr Phe Leu 980
985 990 Asp Ser Ile Ala Gly Thr Leu Lys Ser Met Met Phe Gly Phe His
His 995 1000 1005 Ser Val Thr Val Glu Ile Ile Asn Thr Val Leu Cys
Phe Val Lys Ser 1010 1015 1020 Gly Ile Leu Leu Tyr Val Ile Gln Gln
Leu Asn Gln Asp Glu His Ser 1025 1030 1035 1040 His Ile Ile Gly Leu
Leu Arg Val Met Asn Tyr Ala Asp Ile Gly Cys 1045 1050 1055 Ser Val
Ile Ser Cys Gly Lys Val Phe Ser Lys Met Leu Glu Thr Val 1060 1065
1070 Phe Asn Trp Gln Met Asp Ser Arg Met Met Glu Leu Arg Thr Gln
Ser 1075 1080 1085 Phe Ser Asn Trp Leu Arg Asp Ile Cys Ser Gly Ile
Thr Ile Phe Lys 1090 1095 1100 Ser Phe Lys Asp Ala Ile Tyr Trp Leu
Tyr Thr Lys Leu Lys Asp Phe 1105 1110 1115 1120 Tyr Glu Val Asn Tyr
Gly Lys Lys Lys Asp Ile Leu Asn Ile Leu Lys 1125 1130 1135 Asp Asn
Gln Gln Lys Ile Glu Lys Ala Ile Glu Glu Ala Asp Asn Phe 1140 1145
1150 Cys Ile Leu Gln Ile Gln Asp Val Glu Lys Phe Asp Gln Tyr Gln
Lys 1155 1160 1165 Gly Val Asp Leu Ile Gln Lys Leu Arg Thr Val His
Ser Met Ala Gln 1170 1175 1180 Val Asp Pro Asn Leu Gly Val His Leu
Ser Pro Leu Arg Asp Cys Ile 1185 1190 1195 1200 Ala Arg Val His Gln
Lys Leu Lys Asn Leu Gly Ser Ile Asn Gln Ala 1205 1210 1215 Met Val
Thr Arg Cys Glu Pro Val Val Cys Tyr Leu Tyr Gly Lys Arg 1220 1225
1230 Gly Gly Gly Lys Ser Leu Thr Ser Ile Ala Leu Ala Thr Lys Ile
Cys 1235 1240 1245 Lys His Tyr Gly Val Glu Pro Glu Lys Asn Ile Tyr
Thr Lys Pro Val 1250 1255 1260 Ala Ser Asp Tyr Trp Asp Gly Tyr Ser
Gly Gln Leu Val Cys Ile Ile 1265 1270 1275 1280 Asp Asp Ile Gly Gln
Asn Thr Thr Asp Glu Asp Trp Ser Asp Phe Cys 1285 1290 1295 Gln Leu
Val Ser Gly Cys Pro Met Arg Leu Asn Met Ala Ser Leu Glu 1300 1305
1310 Glu Lys Gly Arg His Phe Ser Ser Pro Phe Ile Ile Ala Thr Ser
Asn 1315 1320 1325 Trp Ser Asn Pro Ser Pro Lys Thr Val Tyr Val Lys
Glu Ala Ile Asp 1330 1335 1340 Arg Arg Leu His Phe Lys Val Glu Val
Lys Pro Ala Ser Phe Phe Lys 1345 1350 1355 1360 Asn Pro His Asn Asp
Met Leu Asn Val Asn Leu Ala Lys Thr Asn Asp 1365 1370 1375 Ala Ile
Lys Asp Met Ser Cys Val Asp Leu Ile Met Asp Gly His Asn 1380 1385
1390 Ile Ser Leu Met Asp Leu Leu Ser Ser Leu Val Met Thr Val Glu
Ile 1395 1400 1405 Arg Lys Gln Asn Met Ser Glu Phe Met Glu Leu Trp
Ser Gln Gly Ile 1410 1415 1420 Ser Asp Asp Asp Asn Asp Ser Ala Val
Ala Glu Phe Phe Gln Ser Phe 1425 1430 1435 1440 Pro Ser Gly Glu Pro
Ser Asn Trp Lys Leu Ser Ser Phe Phe Gln Ser 1445 1450 1455 Val Thr
Asn His Lys Trp Val Ala Val Gly Ala Ala Val Gly Ile Leu 1460 1465
1470 Gly Val Leu Val Gly Gly Trp Phe Val Tyr Lys His Phe Ser Arg
Lys 1475 1480 1485 Glu Glu Glu Pro Ile Pro Ala Glu Gly Val Tyr His
Gly Val Thr Lys 1490 1495 1500 Pro Lys Gln Val Ile Lys Leu Asp Ala
Asp Pro Val Glu Ser Gln Ser 1505 1510 1515 1520 Thr Leu Glu Ile Ala
Gly Leu Val Arg Lys Asn Leu Val Gln Phe Gly 1525 1530 1535 Val Gly
Glu Lys Asn Gly Cys Val Arg Trp Val Met Asn Ala Leu Gly 1540 1545
1550 Val Lys Asp Asp Trp Leu Leu Val Pro Ser His Ala Tyr Lys Phe
Glu 1555 1560 1565 Lys Asp Tyr Glu Met Met Glu Phe Tyr Phe Asn Arg
Gly Gly Thr Tyr 1570 1575 1580 Tyr Ser Ile Ser Ala Gly Asn Val Val
Ile Gln Ser Leu Asp Val Gly 1585 1590 1595 1600 Phe Gln Asp Val Val
Leu Met Lys Val Pro Thr Ile Pro Lys Phe Arg 1605 1610 1615 Asp Ile
Thr Gln His Phe Ile Lys Lys Gly Asp Val Pro Arg Ala Leu 1620 1625
1630 Asn Arg Leu Ala Thr Leu Val Thr Thr Val Asn Gly Thr Pro Met
Leu 1635 1640 1645 Ile Ser Glu Gly Pro Leu Lys Met Glu Glu Lys Ala
Thr Tyr Val His 1650 1655 1660 Lys Lys Asn Asp Gly Thr Thr Val Asp
Leu Thr Val Asp Gln Ala Trp 1665 1670 1675 1680 Arg Gly Lys Gly Glu
Gly Leu Pro Gly Met Cys Gly Gly Ala Leu Val 1685 1690 1695 Ser Ser
Asn Gln Ser Ile Gln Asn Ala Ile Leu Gly Ile His Val Ala 1700 1705
1710 Gly Gly Asn Ser Ile Leu Val Ala Lys Leu Val Thr Gln Glu Met
Phe 1715 1720 1725 Gln Asn Ile Asp Lys Lys Ile Glu Ser Gln Arg Ile
Met Lys Val Glu 1730 1735 1740 Phe Thr Gln Cys Ser Met Asn Val Val
Ser Lys Thr Leu Phe Arg Lys 1745 1750 1755 1760 Ser Pro Ile His His
His Ile Asp Lys Thr Met Ile Asn Phe Pro Ala 1765 1770 1775 Ala Met
Pro Phe Ser Lys Ala Glu Ile Asp Pro Met Ala Met Met Leu 1780 1785
1790 Ser Lys Tyr Ser Leu Pro Ile Val Glu Glu Pro Glu Asp Tyr Lys
Glu 1795 1800 1805 Ala Ser Val Phe Tyr Gln Asn Lys Ile Val Gly Lys
Thr Gln Leu Val 1810 1815 1820 Asp Asp Phe Leu Asp Leu Asp Met Ala
Ile Thr Gly Ala Pro Gly Ile 1825 1830 1835 1840 Asp Ala Ile Asn Met
Asp Ser Ser Pro Gly Phe Pro Tyr Val Gln Glu 1845 1850 1855 Lys Leu
Thr Lys Arg Asp Leu Ile Trp Leu Asp Glu Asn Gly Leu Leu 1860 1865
1870 Leu Gly Val His Pro Arg Leu Ala Gln Arg Ile Leu Phe Asn Thr
Val 1875 1880 1885 Met Met Glu Asn Cys Ser Asp Leu Asp Val Val Phe
Thr Thr Cys Pro 1890 1895 1900 Lys Asp Glu Leu Arg Pro Leu Glu Lys
Val Leu Glu Ser Lys Thr Arg 1905 1910 1915 1920 Ala Ile Asp Ala Cys
Pro Leu Asp Tyr Thr Ile Leu Cys Arg Met Tyr 1925 1930 1935 Trp Gly
Pro Ala Ile Ser Tyr Phe His Leu Asn Pro Gly Phe His Thr 1940 1945
1950 Gly Val Ala Ile Gly Ile Asp Pro Asp Arg Gln Trp Asp Glu Leu
Phe 1955 1960 1965 Lys Thr Met Ile Arg Phe Gly Asp Val Gly Leu Asp
Leu Asp Phe Ser 1970 1975 1980 Ala Phe Asp Ala Ser Leu Ser Pro Phe
Met Ile Arg Glu Ala Gly Arg 1985 1990 1995 2000 Ile Met Ser Glu Leu
Ser Gly Thr Pro Ser His Phe Gly Thr Ala Leu 2005 2010 2015 Ile Asn
Thr Ile Ile Tyr Ser Lys His Leu Leu Tyr Asn Cys Cys Tyr 2020 2025
2030 His Val Cys Gly Ser Met Pro Ser Gly Ser Pro Cys Thr Ala Leu
Leu 2035 2040 2045 Asn Ser Ile Ile Asn Asn Ile Asn Leu Tyr Tyr Val
Phe Ser Lys Ile 2050 2055 2060 Phe Gly Lys Ser Pro Val Phe Phe Cys
Gln Ala Leu Arg Ile Leu Cys 2065 2070 2075 2080 Tyr Gly Asp Asp Val
Leu Ile Val Phe Ser Arg Asp Val Gln Ile Asp 2085 2090 2095 Asn Leu
Asp Leu Ile Gly Gln Lys Ile Val Asp Glu Phe Lys Lys Leu 2100 2105
2110 Gly Met Thr Ala Thr Ser Ala Asp Lys Asn Val Pro Gln Leu Lys
Pro 2115 2120 2125 Val Ser Glu Leu Thr Phe Leu Lys Arg Ser Phe Asn
Leu Val Glu Asp 2130 2135 2140 Arg Ile Arg Pro Ala Ile Ser Glu Lys
Thr Ile Trp Ser Leu Met Ala 2145 2150 2155 2160 Trp Gln Arg Ser Asn
Ala Glu Phe Glu Gln Asn Leu Glu Asn Ala Gln 2165 2170 2175 Trp Phe
Ala Phe Met His Gly Tyr Glu Phe Tyr Gln Lys Phe Tyr Tyr 2180 2185
2190 Phe Val Gln Ser Cys Leu Glu Lys Glu Met Ile Glu Tyr Arg Leu
Lys 2195 2200 2205 Ser Tyr Asp Trp Trp Arg Met Arg Phe Tyr Asp Gln
Cys Phe Ile Cys 2210 2215 2220 Asp Leu Ser 2225 13 9416 DNA
Artificial Sequence Hepatitis C virus sequence 13 gccagccccc
tgatgggggc gacactccac catgaatcac tcccctgtga ggaactactg 60
tcttcacgca gaaagcgtct agccatggcg ttagtatgag tgtcgtgcag cctccaggac
120 cccccctccc gggagagcca tagtggtctg cggaaccggt gagtacaccg
gaattgccag 180 gacgaccggg tcctttcttg gataaacccg ctcaatgcct
ggagatttgg gcgtgccccc 240 gcaagactgc tagccgagta gtgttgggtc
gcgaaaggcc ttgtggtact gcctgatagg 300 gtgcttgcga gtgccccggg
aggtctcgta gaccgtgcac catgagcacg aatcctaaac 360 ctcaaagaaa
aaccaaacgt aacaccaacc gtcgcccaca ggacgtcaag ttcccgggtg 420
gcggtcagat cgttggtgga gtttacttgt tgccgcgcag gggccctaga ttgggtgtgc
480 gcgcgacgag gaagacttcc gagcggtcgc aacctcgagg tagacgtcag
cctatcccca 540 aggcacgtcg gcccgagggc aggacctggg ctcagcccgg
gtacccttgg cccctctatg 600 gcaatgaggg ttgcgggtgg gcgggatggc
tcctgtctcc ccgtggctct cggcctagct 660 ggggccccac agacccccgg
cgtaggtcgc gcaatttggg taaggtcatc gataccctta 720 cgtgcggctt
cgccgacctc atggggtaca taccgctcgt cggcgcccct cttggaggcg 780
ctgccagggc cctggcgcat ggcgtccggg ttctggaaga cggcgtgaac tatgcaacag
840 ggaaccttcc tggttgctct ttctctatct tccttctggc cctgctctct
tgcctgactg 900 tgcccgcttc agcctaccaa gtgcgcaatt cctcggggct
ttaccatgtc accaatgatt 960 gccctaactc gagtgttgtg tacgaggcgg
ccgatgccat cctgcacact ccggggtgtg 1020 tcccttgcgt tcgcgagggt
aacgcctcga ggtgttgggt ggcggtgacc cccacggtgg 1080 ccaccaggga
cggcaaactc cccacaacgc agcttcgacg tcatatcgat ctgcttgtcg 1140
ggagcgccac cctctgctcg gccctctacg tgggggacct gtgcgggtct gtctttcttg
1200 ttggtcaact gtttaccttc tctcccaggc accactggac gacgcaagac
tgcaattgtt 1260 ctatctatcc cggccatata acgggtcatc gcatggcatg
gaatatgatg atgaactggt 1320 cccctacggc agcgttggtg gtagctcagc
tgctccgaat cccacaagcc atcatggaca 1380 tgatcgctgg cgcccactgg
ggagtcctgg cgggcataaa gtatttctcc atggtgggga 1440 actgggcgaa
ggtcctggta gtgctgctgc tatttgccgg cgtcgacgcg gaaacccacg 1500
tcaccggggg aaatgccggc cgcaccacgg ctgggcttgt tggtctcctt acaccaggcg
1560 ccaagcagaa catccaactg atcaacacca acggcagttg gcacatcaat
agcacggcct 1620 tgaactgcaa tgaaagcctt aacaccggct ggttagcagg
gctcttctat cagcacaaat 1680 tcaactcttc aggctgtcct gagaggttgg
ccagctgccg acgccttacc gattttgccc 1740 agggctgggg tcctatcagt
tatgccaacg gaagcggcct cgacgaacgc ccctactgct 1800 ggcactaccc
tccaagacct tgtggcattg tgcccgcaaa gagcgtgtgt ggcccggtat 1860
attgcttcac tcccagcccc gtggtggtgg gaacgaccga caggtcgggc gcgcctacct
1920 acagctgggg tgcaaatgat acggatgtct tcgtccttaa caacaccagg
ccaccgctgg 1980 gcaattggtt cggttgtacc tggatgaact caactggatt
caccaaagtg tgcggagcgc 2040 ccccttgtgt catcggaggg gtgggcaaca
acaccttgct ctgccccact gattgcttcc 2100 gcaaatatcc ggaagccaca
tactctcggt gcggctccgg tcccaggatt acacccaggt 2160 gcatggtcga
ctacccgtat aggctttggc actatccttg taccatcaat tacaccatat 2220
tcaaagtcag gatgtacgtg ggaggggtcg agcacaggct ggaagcggcc tgcaactgga
2280 cgcggggcga acgctgtgat ctggaagaca gggacaggtc cgagctcagc
ccgttgctgc 2340 tgtccaccac acagtggcag gtccttccgt gttctttcac
gaccctgcca gccttgtcca 2400 ccggcctcat ccacctccac cagaacattg
tggacgtgca gtacttgtac ggggtagggt 2460 caagcatcgc gtcctgggcc
attaagtggg agtacgtcgt tctcctgttc cttctgcttg 2520 cagacgcgcg
cgtctgttcc tgcttgtgga tgatgttact catatcccaa gcggaggcgg 2580
ctttggagaa cctcgtaata ctcaatgcag catccctggc cgggacgcat ggtcttgtgt
2640 ccttcctcgt gttcttctgc tttgcgtggt atctgaaggg taggtgggtg
cccggagcgg 2700 tctacgccct ctacgggatg tggcctctcc tcctgctcct
gctggcgttg cctcagcggg 2760 catacgcact ggacacggag gtggccgcgt
cgtgtggcgg cgttgttctt gtcgggttaa 2820 tggcgctgac tctgtcgcca
tattacaagc gctatatcag ctggtgcatg tggtggcttc 2880 agtattttct
gaccagagta gaagcgcaac tgcacgtgtg ggttcccccc ctcaacgtcc 2940
ggggggggcg cgatgccgtc atcttactca cgtgtgtagt acacccggcc ctggtatttg
3000 acatcaccaa actactcctg gccatcttcg gacccctttg gattcttcaa
gccagtttgc 3060 ttaaagtccc ctacttcgtg cgcgttcaag gccttctccg
gatctgcgcg ctagcgcgga 3120 agatagccgg aggtcattac gtgcaaatgg
ccatcatcaa gttaggggcg cttactggca 3180 cctgtgtgta taaccatctc
gctcctcttc gagactgggc gcacaacggc ctgcgagatc 3240 tggccgtggc
tgtggaacca gtcgtcttct cccgaatgga gaccaagctc atcacgtggg 3300
gggcagatac cgccgcgtgc ggtgacatca tcaacggctt gcccgtctct gcccgtaggg
3360 gccaggagat actgcttggg ccagccgacg gaatggtctc caaggggtgg
aggttgctgg 3420 cgcccatcac ggcgtacgcc cagcagacga gaggcctcct
agggtgtata atcaccagcc 3480 tgactggccg ggacaaaaac caagtggagg
gtgaggtcca gatcgtgtca actgctaccc 3540 agaccttcct ggcaacgtgc
atcaatgggg tatgctggac tgtctaccac ggggccggaa 3600 cgaggaccat
cgcatcaccc aagggtcctg tcatccagac gtataccaat gtggatcaag 3660
acctcgtggg ctggcccgct cctcaaggtt cccgctcatt gacaccctgc acctgcggct
3720 cctcggacct ttacctggtc acgaggcacg ccgatgtcat tcccgtgcgc
cggcgaggtg 3780 atagcagggg tagcctgctt tcgccccggc ccatttccta
cttgaaaggc tcctcggggg 3840 gtccgctgtt gtgccccacg ggacacgccg
tgggcctatt cagggccgcg gtgtgcaccc 3900 gtggagtggc taaggcggtg
gactttatcc ctgtggagaa cctagagaca accatgagat 3960 ccccggtgtt
cacggacaac tcctctccac cagcagtgcc ccagagcttc caggtggccc 4020
acctgcatgc tcccaccggc agcggtaaga gcaccaaggt cccggctgcg tacgcagcca
4080 agggctacaa ggtgttggtg ctcaacccct ctgttgctgc aacactgggc
tttggtgctt 4140 acatgtccaa ggcccatggg gttgatccta atatcaggac
cggggtgaga acaattacca 4200 ctggcagccc catcacgtac tccacctacg
gcaagttcct tgccgacgcc gggtgctcag 4260 gaggtgctta tgacataata
atttgtgacg agtgccactc cacggatgcc acatccatct 4320 cgggcatcgg
cactgtcctt gaccaagcag agactgcggg ggcgagactg gttgtgctcg 4380
ccactgctac ccctccgggc tccgtcactg tgtcccatcc taacatcgag gaggttgctc
4440 tgtccaccac cggagagatc cccttttacg gcaaggctat ccccctcgag
gtgatcaagg 4500 ggggaagaca tctcatcttc tgccactcaa agaagaagtg
cgacgagctc gccgcgaagc 4560 tggtcgcatt gggcatcaat gccgtggcct
actaccgcgg tcttgacgtg tctgtcatcc 4620 cgaccagcgg cgatgttgtc
gtcgtgtcga ccgatgctct catgactggc tttaccggcg 4680 acttcgactc
tgtgatagac tgcaacacgt gtgtcactca gacagtcgat tttagccttg 4740
accctacctt taccattgag acaaccacgc tcccccagga tgctgtctcc aggactcaac
4800 gccggggcag gactggcagg gggaagccag gcatctatag atttgtggca
ccgggggagc 4860 gcccctccgg catgttcgac tcgtccgtcc tctgtgagtg
ctatgacgcg ggctgtgctt 4920 ggtatgagct cacgcccgcc gagactacag
ttaggctacg agcgtacatg aacaccccgg 4980 ggcttcccgt gtgccaggac
catcttggat tttgggaggg cgtctttacg ggcctcactc 5040 atatagatgc
ccactttcta tcccagacaa agcagagtgg ggagaacttt ccttacctgg 5100
tagcgtacca agccaccgtg tgcgctaggg ctcaagcccc tcccccatcg tgggaccaga
5160 tgcggaagtg tttgatccgc cttaaaccca ccctccatgg gccaacaccc
ctgctataca 5220 gactgggcgc tgttcagaat gaagtcaccc tgacgcaccc
aatcaccaaa tacatcatga 5280 catgcatgtc ggccgacctg gaggtcgtca
cgagcacctg ggtgctcgtt ggcggcgtcc 5340 tggctgctct ggccgcgtat
tgcctgtcaa caggctgcgt ggtcatagtg ggcaggatcg 5400 tcttgtccgg
gaagccggca attatacctg acagggaggt tctctaccag gagttcgatg 5460
agatggaaga gtgctctcag cacttaccgt acatcgagca agggatgatg ctcgctgagc
5520 agttcaagca gaaggccctc ggcctcctgc agaccgcgtc ccgccatgca
gaggttatca 5580 cccctgctgt ccagaccaac tggcagaaac tcgaggtctt
ttgggcgaag cacatgtgga 5640 atttcatcag tgggatacaa tacttggcgg
gcctgtcaac gctgcctggt aaccccgcca 5700 ttgcttcatt gatggctttt
acagctgccg tcaccagccc actaaccact ggccaaaccc 5760 tcctcttcaa
catattgggg gggtgggtgg ctgcccagct cgccgccccc ggtgccgcta 5820
ccgcctttgt gggcgctggc ttagctggcg ccgcactcga cagcgttgga ctggggaagg
5880 tcctcgtgga cattcttgca ggctatggcg cgggcgtggc gggagctctt
gtggcattca 5940 agatcatgag cggtgaggtc ccctccacgg aggacctggt
caatctgctg cccgccatcc 6000 tctcacctgg agcccttgca gtcggtgtgg
tctttgcatc aatactgcgc cggcgtgttg 6060 gcccgggcga gggggcagtg
caatggatga accggctaat agccttcgcc tcccggggga 6120 accatgtttc
ccccacacac tacgtgccgg agagcgatgc agccgcccgc gtcactgcca 6180
tactcagcag cctcactgta acccagctcc tgaggcgact gcatcagtgg ataagctcgg
6240 agtgtaccac tccatgctcc ggttcctggc taagggacat ctgggactgg
atatgcgagg 6300 tgctgagcga ctttaagacc tggctgaaag ccaagctcat
gccacaactg cctgggattc 6360 cctttgtgtc ctgccagcgc gggtataggg
gggtctggcg aggagacggc attatgcaca 6420 ctcgctgcca ctgtggagct
gagatcactg gacatgtcaa aaacgggacg atgaggatcg 6480 tcggtcctag
gacctgcaag aacatgtgga gtgggacgtt cttcattaat gcctacacca 6540
cgggcccctg tactcccctt cctgcgccga actataagtt cgcgctgtgg agggtgtctg
6600 cagaggaata cgtggagata aggcgggtgg gggacttcca ctacgtatcg
ggcatgacta 6660 ctgacaatct caaatgcccg tgccagatcc catcgcccga
atttttcaca gaattggacg 6720 gggtgcgcct acataggttt gcgccccctt
gcaagccctt gctgcgggag gaggtatcat 6780 tcagagtagg actccacgag
tacccggtgg ggtcgcaatt accttgcgag cccgaaccgg 6840 acgtagccgt
gttgacgtcc atgctcactg atccctccca tataacagca gaggcggccg 6900
ggagaaggtt ggcgagaggg tcaccccctt
ctatggccag ctcctcggct agccagctgt 6960 ccgctccatc tctcaaggca
acttgcaccg ccaaccatga ctcccctgac gccgagctca 7020 tagaggctaa
cctcctgtgg aggcaggaga tgggcggcaa catcaccagg gttgagtcag 7080
agaacaaagt ggtgattctg gactccttcg atccgcttgt ggcagaggag gatgagcggg
7140 aggtctccgt acccgcagaa attctgcgga agtctcggag attcgcccca
gccctgcccg 7200 tctgggcgcg gccggactac aaccccctgc tagtagagac
gtggaaaaag cctgactacg 7260 aaccacctgt ggtccatggc tgcccgctac
cacctccacg gtcccctcct gtgcctccgc 7320 ctcggaaaaa gcgtacggtg
gtcctcaccg aatcaaccct acctactgcc ttggccgagc 7380 ttgccaccaa
aagttttggc agctcctcaa cttccggcat tacgggcgac aatacgacaa 7440
catcctctga gcccgcccct tctggctgcc cccccgactc cgacgttgag tcctattctt
7500 ccatgccccc cctggagggg gagcctgggg atccggatct cagcgacggg
tcatggtcga 7560 cggtcagtag tggggccgac acggaagatg tcgtgtgctg
ctcaatgtct tattcctgga 7620 caggcgcact cgtcaccccg tgcgctgcgg
aggaacaaaa actgcccatc aacgcactga 7680 gcaactcgtt gctacgccat
cacaatctgg tgtattccac cacttcacgc agtgcttgcc 7740 aaaggaagaa
gaaagtcaca tttgacagac tgcaagttct ggacagccat taccaggacg 7800
tgctcaagga ggtcaaagca gcggcgtcaa aagtgaaggc taacttgcta tccgtagagg
7860 aagcttgcag cctggcgccc ccacattcag ccaaatccaa gtttggctat
ggggcaaaag 7920 acgtccgttg ccatgccaga aaggccgtag cccacatcaa
ctccgtgtgg aaagaccttc 7980 tggaagacag tgtaacacca atagacacta
ccatcatggc caagaacgag gttttctgcg 8040 ttcagcctga gaaggggggt
cgtaagccag ctcgtctcat cgtgttcccc gacctgggcg 8100 tgcgcgtgtg
cgagaagatg gccctgtacg acgtggttag caagctcccc ttggccgtga 8160
tgggaagctc ctacggattc caatactcac caggacagcg ggttgaattc ctcgtgcaag
8220 cgtggaagtc caagaagacc ccgatggggc tctcgtatga tacccgctgt
tttgactcca 8280 cagtcactga gagcgacatc cgtacggagg aggcaattta
ccaatgttgt gacctggacc 8340 cccaagcccg cgtggccatc aagtccctca
ctgagaggct ttatgttggg ggccctctta 8400 ctaattcaag gggggaaaac
tgcggctacc gcaggtgccg cgcgagcaga gtactgacaa 8460 ctagctgtgg
taacaccctc actcgctaca tcaaggcccg ggcagcctgt cgagccgcag 8520
ggctccagga ctgcaccatg ctcgtgtgtg gcgacgactt agtcgttatc tgtgaaagtg
8580 cgggggtcca ggaggacgcg gcgagcctga gagccttcac ggaggctatg
accaggtact 8640 ccgccccccc cggggacccc ccacaaccag aatacgactt
ggagcttata acatcatgct 8700 cctccaacgt gtcagtcgcc cacgacggcg
ctggaaagag ggtctactac cttacccgtg 8760 accctacaac ccccctcgcg
agagccgcgt gggagacagc aagacacact ccagtcaatt 8820 cctggctagg
caacataatc atgtttgccc ccacactgtg ggcgaggatg atactgatga 8880
cccacttctt tagcgtcctc atagccaggg atcagcttga acaggctctc aactgcgaga
8940 tctacggagc ctgctactcc atagaaccac tggatctacc tccaatcatt
caaagactcc 9000 atggcctcag cgcattttca ctccacagtt actctccagg
tgaaattaat agggtggccg 9060 catgcctcag aaaacttggg gtcccgccct
tgcgagcttg gagacaccgg gcctggagcg 9120 tccgcgctag gcttctggcc
agaggaggca aggctgccat atgtggcaag tacctcttca 9180 actgggcagt
aagaacaaag ctcaaactca ctccgataac ggccgctggc cggctggact 9240
tgtccggctg gttcacggct ggctacagcg ggggagacat ttatcacagc gtgtctcatg
9300 cccggccccg ctggttctgg ttttgcctac tcctgcttgc tgcaggggta
ggcatctacc 9360 tcctccccaa ccgatgaaga ttgggctaac cactccaggc
caataggcca ttccct 9416 14 3182 DNA Artificial Sequence Hepatitis B
virus sequence 14 aattccacaa ccttccacca aactctgcaa gatcccagag
tgagaggcct gtatttccct 60 gctggtggct ccagttcagg aacagtaaac
cctgttctga ctactgcctc tcccttatcg 120 tcaatcttct cgaggattgg
ggaccctgcg ctgaacatgg agaacatcac atcaggattc 180 ctaggacccc
ttctcgtgtt acaggcgggg tttttcttgt tgacaagaat cctcacaata 240
ccgcagagtc tagactcgtg gtggacttct ctcaattttc tagggggaac taccgtgtgt
300 cttggccaaa attcgcagtc cccaacctcc aatcactcac caacctcttg
tcctccaact 360 tgtcctggtt atcgctggat gtgtctgcgg cgttttatca
tcttcctctt catcctgctg 420 ctatgcctca tcttcttgtt ggttcttctg
gactatcaag gtatgttgcc cgtttgtcct 480 ctaattccag gatcctcaac
aaccagcacg ggaccatgcc ggacctgcat gactactgct 540 caaggaacct
ctatgtatcc ctcctgttgc tgtaccaaac cttcggacgg aaattgcacc 600
tgtattccca tcccatcatc ctgggctttc ggaaaattcc tatgggagtg ggcctcagcc
660 cgtttctcct ggctcagttt actagtgcca tttgttcagt ggttcgtagg
gctttccccc 720 actgtttggc tttcagttat atggatgatg tggtattggg
ggccaagtct gtacagcatc 780 ttgagtccct ttttaccgct gttaccaatt
ttcttttgtc tttgggtata catttaaacc 840 ctaacaaaac aaagagatgg
ggttactctc taaattttat gggttatgtc attggatgtt 900 atgggtcctt
gccacaagaa cacatcatac aaaaaatcaa agaatgtttt agaaaacttc 960
ctattaacag gcctattgat tggaaagtat gtcaacgaat tgtgggtctt ttgggttttg
1020 ctgccccttt tacacaatgt ggttatcctg cgttgatgcc tttgtatgca
tgtattcaat 1080 ctaagcaggc tttcactttc tcgccaactt acaaggcctt
tctgtgtaaa caatacctga 1140 acctttaccc cgttgcccgg caacggccag
gtctgtgcca agtgtttgct gacgcaaccc 1200 ccactggctg gggcttggtc
atgggccatc agcgcatgcg tggaaccttt tcggctcctc 1260 tgccgatcca
tactgcggaa ctcctagccg cttgttttgc tcgcagcagg tctggagcaa 1320
acattatcgg gactgataac tctgttgtcc tatcccgcaa atatacatcg tttccatggc
1380 tgctaggctg tgctgccaac tggatcctgc gcgggacgtc ctttgtttac
gtcccgtcgg 1440 cgctgaatcc tgcggacgac ccttctcggg gtcgcttggg
actctctcgt ccccttctcc 1500 gtctgccgtt ccgaccgacc acggggcgca
cctctcttta cgcggactcc ccgtctgtgc 1560 cttctcatct gccggaccgt
gtgcacttcg cttcacctct gcacgtcgca tggagaccac 1620 cgtgaacgcc
caccaaatat tgcccaaggt cttacataag aggactcttg gactctcagc 1680
aatgtcaacg accgaccttg aggcatactt caaagactgt ttgtttaaag actgggagga
1740 gttgggggag gagattaggt taaaggtctt tgtactagga ggctgtaggc
ataaattggt 1800 ctgcgcacca gcaccatgca actttttcac ctctgcctaa
tcatctcttg ttcatgtcct 1860 actgttcaag cctccaagct gtgccttggg
tggctttggg gcatggacat cgacccttat 1920 aaagaatttg gagctactgt
ggagttactc tcgtttttgc cttctgactt ctttccttca 1980 gtacgagatc
ttctagatac cgcctcagct ctgtatcggg aagccttaga gtctcctgag 2040
cattgttcac ctcaccatac tgcactcagg caagcaattc tttgctgggg ggaactaatg
2100 actctagcta cctgggtggg tgttaatttg gaagatccag cgtctagaga
cctagtagtc 2160 agttatgtca acactaatat gggcctaaag ttcaggcaac
tcttgtggtt tcacatttct 2220 tgtctcactt ttggaagaga aacagttata
gagtatttgg tgtctttcgg agtgtggatt 2280 cgcactcctc cagcttatag
accaccaaat gcccctatcc tatcaacact tccggagact 2340 actgttgtta
gacgacgagg caggtcccct agaagaagaa ctccctcgcc tcgcagacga 2400
aggtctcaat cgccgcgtcg cagaagatct caatctcggg aatctcaatg ttagtattcc
2460 ttggactcat aaggtgggga actttactgg gctttattct tctactgtac
ctgtctttaa 2520 tcctcattgg aaaacaccat cttttcctaa tatacattta
caccaagaca ttatcaaaaa 2580 atgtgaacag tttgtaggcc cactcacagt
taatgagaaa agaagattgc aattgattat 2640 gcctgccagg ttttatccaa
aggttaccaa atatttacca ttggataagg gtattaaacc 2700 ttattatcca
gaacatctag ttaatcatta cttccaaact agacactatt tacacactct 2760
atggaaggcg ggtatattat ataagagaga aacaacacat agcgcctcat tttgtgggtc
2820 accatattct tgggaacaag atctacagca tggggcagaa tctttccacc
agcaatcctc 2880 tgggattctt tcccgaccac cagttggatc cagccttcag
agcaaacacc gcaaatccag 2940 attgggactt caatcccaac aaggacacct
ggccagacgc caacaaggta ggagctggag 3000 cattcgggct gggtttcacc
ccaccgcacg gaggcctttt ggggtggagc cctcaggctc 3060 agggcatact
acaaactttg ccagcaaatc cgcctcctgc ctccaccaat cgccagtcag 3120
gaaggcagcc taccccgctg tctccacctt tgagaaacac tcatcctcag gccatgcagt
3180 gg 3182 15 7478 DNA Artificial Sequence Hepatitis A virus
sequence 15 ttcaagaggg gtctccggag gtttccggag cccctcttgg aagtccatgg
tgaggggact 60 tgatacctca ccgccgtttg cctaggctat aggctaaatt
tccctttccc tgtccctccc 120 ttatttccct ttgttttgct tgtaaatatt
aattcctgca ggttcagggt tctttaatct 180 gtttctctat aagaacactc
aattttcacg ctttctgtct tctttcttcc agggctctcc 240 ccttgcccta
ggctctggcc gttgcgcccg gcggggtcaa ctccatgatt agcatggagc 300
tgtaggagtc taaattgggg acgcagatgt ttgggacgtc accttgcagt gttaacttgg
360 ctctcatgaa cctctttgat cttccacaag gggtaggcta cgggtgaaac
ctcttaggct 420 aatacttcta tgaagagatg ctttggatag ggtaacagcg
gcggatattg gtgagttgtt 480 aagacaaaaa ccattcaacg ccggaggact
ggctctcatc cagtggatgc attgagtgga 540 ttgattgtca gggctgtctc
taggtttaat ctcagacctc tctgtgctta gggcaaacac 600 catttggcct
taaatgggat cctgtgagag ggggtccctc cattgacagc tggactgttc 660
tttggggcct tatgtggtgt ttgcctctga ggtactcagg ggcatttagg tttttcctca
720 ttcttaaaca ataatgaata tgtccaaaca aggaattttc cagactgttg
ggagtggcct 780 tgaccacatc ctgtctttgg cagatattga ggaagagcaa
atgattcagt ccgttgatag 840 gactgcagtg actggagctt cttacttcac
ttctgtggac caatcttcag ttcatactgc 900 tgaggttggc tcacatcaaa
ttgaaccttt gaaaacctct gttgataaac ctggttctaa 960 gaaaactcag
ggggaaaagt ttttcctgat tcattctgct gattggctca ctacacatgc 1020
tctctttcat gaagttgcaa aattggatgt ggtgaaacta ctgtataatg agcagtttgc
1080 cgtccaaggt ttgttgagat accatacata tgcaagattt ggcattgaga
ttcaagttca 1140 gataaatccc acaccctttc agcaaggagg actaatttgt
gccatggttc ctggtgacca 1200 aagttatggt tcaatagcat ccttgactgt
ttatcctcat ggtctgttaa attgcaatat 1260 caacaatgta gttagaataa
aggttccatt tatttatact agaggtgctt atcattttaa 1320 agatccacag
tacccagttt gggaattgac aatcagagtt tggtcagagt tgaatattgg 1380
aacaggaact tcagcttaca cttcactcaa tgttttagct aggtttacag atttggagtt
1440 gcatggatta actcctcttt ctacacagat gatgagaaat gaatttaggg
tcagtactac 1500 tgaaaatgtt gtaaatttgt caaattatga agatgcaagg
gcaaaaatgt cttttgcttt 1560 ggatcaggaa gattggaagt ctgatccttc
ccaaggtggt ggaattaaaa ttactcattt 1620 tactacctgg acatccattc
caaccttagc tgctcagttt ccatttaatg cttcagattc 1680 agttggacaa
caaattaaag ttattccagt ggacccatac tttttccaaa tgacaaacac 1740
taatcctgat caaaaatgta taactgcctt ggcctctatt tgtcagatgt tctgcttttg
1800 gaggggagat cttgtttttg attttcaggt ttttccaacc aaatatcatt
caggtagact 1860 gttgttttgt tttgttcctg ggaatgagtt aatagatgtt
actggaatta cattaaaaca 1920 ggcaactact gctccttgtg cagtgatgga
cattacagga gtgcagtcaa ccttgagatt 1980 tcgtgttcct tggatttctg
atacacctta tcgagtgaat aggtacacga agtcagcaca 2040 tcaaaaaggt
gagtacactg ccattgggaa gcttattgtg tattgttata acagactgac 2100
ttctccttct aatgttgcct ctcatgttag agttaatgtt tatctttcag caattaattt
2160 ggaatgtttt gctcctcttt accatgctat ggatgttact acacaggttg
gagatgattc 2220 aggaggtttc tcaacaacag tttctacaga gcagaatgtt
cctgatcccc aagttgggat 2280 aacaaccatg agggatttaa aaggaaaagc
caatagggga aagatggatg tttcaggagt 2340 gcaagcacct cgtgggagct
atcagcaaca attgaacgat ccagttttag caaagaaagt 2400 acctgagaca
tttcctgaat tgaagcctgg agagtccaga catacatcag atcacatgtc 2460
tatttataaa ttcatgggaa ggtctcattt tttgtgcact tttactttca attcaaataa
2520 taaagagtac acatttccaa taaccctgtc ttcgacttct aatcctcctc
atggtttacc 2580 atcaacatta aggtggttct tcaatttgtt tcagttgtat
agaggaccat tggatttaac 2640 aattataatc acaggagcca ctgatgtgga
tggtatggcc tggtttactc cagtgggcct 2700 tgctgtcgac ccttgggtgg
aaaaggagtc agctttgtct attgattata aaactgccct 2760 tggagctgtt
agatttaata caagaagaac aggaaacatt caaattagat tgccgtggta 2820
ttcttatttg tatgccgtgt ctggagcact ggatggcttg ggggataaga cagattctac
2880 atttggattg tttctattcg agattgcaaa ttacaatcat tctgatgaat
atttgtcctt 2940 cagttgttat ttgtctgtca cagagcaatc agagttctat
tttcctagag ctccattaaa 3000 ttcaaatgct atgttgtcca ctgaatccat
gatgagtaga attgcagctg gagacttgga 3060 gtcatcagtg gatgatccca
gatcagagga ggatagaaga tttgagagtc atatagaatg 3120 taggaaacca
tacaaagaat tgagactgga ggttgggaaa caaagactca aatatgctca 3180
ggaagagtta tcaaatgaag tgcttccacc tcctaggaaa atgaaggggt tattttcaca
3240 agctaaaatt tctctttttt atactgagga gcatgaaata atgaagtttt
cttggagagg 3300 agtgactgct gatactaggg ctttgagaag atttggattc
tctctggctg ctggtagaag 3360 tgtgtggact cttgaaatgg atgctggagt
tcttactgga agattgatca gattgaatga 3420 tgagaaatgg acagaaatga
aggatgataa gattgtttca ttaattgaaa agttcacaag 3480 caataaatat
tggtctaaag tgaattttcc acatggaatg ttggatcttg aagaaattgc 3540
tgccaattct aaggattttc caaatatgtc tgagacagat ttgtgtttcc tgttacattg
3600 gctaaatcca aagaaaatca atttagcaga tagaatgctt ggattgtctg
gagtgcagga 3660 aattaaggaa cagggtgttg gactgatagc agagtgtaga
actttcttgg attctattgc 3720 tgggactttg aaatctatga tgtttgggtt
tcatcattct gtgactgttg aaattataaa 3780 tactgtgctt tgttttgtta
agagtggaat cctgctttat gtcatacaac aattgaacca 3840 agatgaacac
tctcacataa ttggtttgtt gagagttatg aattatgcag atattggctg 3900
ttcagttatt tcatgtggta aagttttttc caaaatgtta gaaacagttt ttaattggca
3960 aatggattct agaatgatgg agctgaggac tcagagcttc tctaattggt
taagagatat 4020 ttgttcagga attactattt ttaaaagttt taaggatgcc
atatattggt tatatacaaa 4080 attgaaggat ttttatgaag taaattatgg
caagaaaaag gatattctta atattctcaa 4140 agataatcag caaaaaatag
aaaaagccat tgaagaagca gacaattttt gcattttgca 4200 aattcaagat
gtagagaaat ttgatcagta tcagaaaggg gttgatttaa tacaaaagct 4260
gagaactgtc cattcaatgg cgcaagttga ccccaatttg ggggttcatt tgtcacctct
4320 cagagattgc atagcaagag tccaccaaaa gctcaagaat cttggatcta
taaatcaggc 4380 catggtaaca agatgtgagc cagttgtttg ctatttgtat
ggcaaaagag ggggagggaa 4440 aagcttgact tcaattgcat tggcaaccaa
aatttgtaaa cactatggtg ttgaacctga 4500 gaaaaatatt tacaccaaac
ctgtggcctc agattattgg gatggatata gtggacaatt 4560 agtttgcatt
attgatgata ttggccaaaa cacaacagat gaagattggt cagatttttg 4620
tcaattagtg tcaggatgcc caatgagatt gaatatggct tctctagagg agaagggcag
4680 acatttttcc tctcctttta taatagcaac ttcaaattgg tcaaatccaa
gtccaaaaac 4740 agtttatgtt aaggaagcaa ttgatcgtag gcttcatttt
aaggttgaag ttaaacctgc 4800 ttcatttttt aaaaatcctc acaatgatat
gttgaatgtt aatttggcca aaacaaatga 4860 tgcaattaag gacatgtctt
gtgttgattt aataatggat ggacacaata tttcattgat 4920 ggatttactt
agttccttag tgatgacagt tgaaattagg aaacagaata tgagtgaatt 4980
catggagttg tggtctcagg gaatttcaga tgatgacaat gatagtgcag tggctgagtt
5040 tttccagtct tttccatctg gtgaaccatc aaattggaag ttatctagtt
ttttccaatc 5100 tgtcactaat cacaagtggg ttgctgtggg agctgcagtt
ggcattcttg gagtgcttgt 5160 gggaggatgg tttgtgtata agcatttttc
ccgcaaagag gaagaaccaa ttccagctga 5220 aggggtttat catggcgtga
ctaagcccaa acaagtgatt aaattggatg cagatccagt 5280 agagtcccag
tcaactctag aaatagcagg attagttagg aaaaatctgg ttcagtttgg 5340
agttggtgag aaaaatggat gtgtgagatg ggtcatgaat gccttaggag tgaaggatga
5400 ttggttgtta gtaccttctc atgcttataa atttgaaaag gattatgaaa
tgatggagtt 5460 ttacttcaat agaggtggaa cttactattc aatttcagct
ggtaatgttg ttattcaatc 5520 tttagatgtg ggatttcaag atgttgtttt
aatgaaggtt cctacaattc ccaagtttag 5580 agatattact caacacttta
ttaagaaagg agatgtgcct agagccttaa atcgcttggc 5640 aacattagtg
acaaccgtta atggaactcc tatgttaatt tctgagggac cattaaagat 5700
ggaagaaaaa gccacttatg ttcataagaa gaatgatggt actacagttg atttgactgt
5760 agatcaggca tggagaggaa aaggtgaagg tcttcctgga atgtgtggtg
gggccctagt 5820 gtcatcaaat cagtccatac agaatgcaat tttgggtatt
catgttgctg gaggaaattc 5880 aattcttgtg gcaaagctgg ttactcaaga
aatgtttcaa aacattgata agaaaattga 5940 aagtcagaga ataatgaaag
tggaatttac tcaatgttca atgaatgtag tctccaaaac 6000 gctttttaga
aagagtccca ttcatcacca cattgataaa accatgatta attttcctgc 6060
agctatgcct ttctctaaag ctgaaattga tccaatggct atgatgttgt ccaaatattc
6120 attacctatt gtggaggaac cagaggatta caaggaagct tcagtttttt
atcaaaacaa 6180 aatagtaggc aagactcagc tagttgatga ctttttagat
cttgatatgg ctattacagg 6240 ggctccaggc attgatgcta tcaatatgga
ttcatctcct gggtttcctt atgttcaaga 6300 aaaattgacc aaaagagatt
taatttggtt ggatgaaaat ggtttgctgt taggagttca 6360 cccaagattg
gcccagagaa ttttatttaa tactgtcatg atggaaaatt gttctgactt 6420
agatgttgtt tttacaactt gtccaaaaga tgaattgaga ccattagaga aagttttgga
6480 atcaaaaaca agagccattg atgcttgtcc tttggattat acaattctat
gtcgaatgta 6540 ttggggtcca gctatcagtt atttccattt gaatccaggg
tttcacacag gtgttgctat 6600 tggcatagat cctgatagac agtgggatga
attatttaaa acaatgataa gatttggaga 6660 tgttggtctt gatttagatt
tctctgcttt tgatgccagt cttagtccat ttatgattag 6720 ggaagcaggt
agaatcatga gtgaattatc tggaacacca tctcattttg gaacagctct 6780
tatcaatact atcatttatt ctaaacatct gctgtacaac tgttgttatc atgtttgtgg
6840 ttcaatgcct tctgggtctc cttgcacagc tttgttgaat tcaattatta
ataatattaa 6900 tctgtattat gtgttttcta aaatatttgg aaagtctcca
gttttctttt gtcaagcttt 6960 gaggatcctt tgttacggag atgatgtttt
gatagttttt tccagagatg ttcaaattga 7020 caatcttgac ttgattggac
agaaaattgt agatgagttc aaaaaacttg gcatgacagc 7080 cacctcagct
gataaaaatg tgcctcaact gaagccagtt tcagaattga cttttctcaa 7140
aagatctttc aatttggtgg aggatagaat tagacctgca atttcagaaa agacaatttg
7200 gtctttgatg gcttggcaga gaagtaacgc tgagtttgag cagaatttag
aaaatgctca 7260 gtggtttgct tttatgcatg gctatgagtt ctatcagaaa
ttttattatt ttgttcagtc 7320 ctgtttggag aaagagatga tagaatatag
acttaaatct tatgattggt ggagaatgag 7380 attttatgac cagtgtttca
tttgtgacct ttcatgattt gtttaaacaa attttcttac 7440 tctttctgag
gtttgtttat ttcttttgtc cgctaact 7478
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