U.S. patent application number 11/280361 was filed with the patent office on 2006-07-06 for herbal nutraceutical formulation for diabetics and process for preparing the same.
Invention is credited to Dhan Prakash, Palpu Pushpangadan.
Application Number | 20060147561 11/280361 |
Document ID | / |
Family ID | 28452790 |
Filed Date | 2006-07-06 |
United States Patent
Application |
20060147561 |
Kind Code |
A1 |
Pushpangadan; Palpu ; et
al. |
July 6, 2006 |
Herbal nutraceutical formulation for diabetics and process for
preparing the same
Abstract
The present invention relates to a herbal nutraceutical
formulation for diabetics, and also relates to a process for the
preparation of the formulation. The formulation comprises the base
product of a microwave roasted seed powder mixture from selected
genera of Glycine, Cicer, Phaseolus, Cyamompsis, Mucuna, Hordeum,
Amaranthus and Fagopyrum, fortified with herbs/medicinal plants
selected from the genera of Gymnema, Momordica, Syzgium,
Pterocarpus, Trigonella, Cinnamomum, Withania, Coccinia, Pueraria,
Asparagus, Boerhaavia and Aegle. Other ingredients like Piper
longum, Chlorophytum tuberosum, Curcuma longa and Elettaria
cardamomum are also added to the final nutraceutical product. The
nutraceuticals are non toxic, natural herbal plant products, easy
to digest that ameliorate the general health and vigor of
diabetics.
Inventors: |
Pushpangadan; Palpu;
(Lucknow, IN) ; Prakash; Dhan; (Lucknow,
IN) |
Correspondence
Address: |
RATNERPRESTIA
P O BOX 980
VALLEY FORGE
PA
19482-0980
US
|
Family ID: |
28452790 |
Appl. No.: |
11/280361 |
Filed: |
November 16, 2005 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
|
|
10108095 |
Mar 26, 2002 |
7014872 |
|
|
11280361 |
Nov 16, 2005 |
|
|
|
Current U.S.
Class: |
424/734 ;
424/750; 424/756; 424/757; 424/762; 424/773; 424/776 |
Current CPC
Class: |
A61K 2300/00 20130101;
A23L 33/105 20160801; A61K 36/00 20130101; A61K 36/00 20130101 |
Class at
Publication: |
424/734 ;
424/750; 424/757; 424/776; 424/756; 424/773; 424/762 |
International
Class: |
A61K 36/899 20060101
A61K036/899; A61K 36/67 20060101 A61K036/67; A61K 36/906 20060101
A61K036/906; A61K 36/48 20060101 A61K036/48; A61K 36/10 20060101
A61K036/10 |
Claims
1.-20. (canceled)
21. A process for the preparation of a herbal nutraceutical product
useful as food supplement for diabetics, said process comprising:
a. selecting seeds from the group of the legumes Glycine max, Cicer
arietinum, Phaseolus mungo, Phaseolus radiatus, Cyamopsis
tetragonoloba, and Mucuna pruriens; the cereal Hordeum vulgare; and
the pseudocereals Amaranthus hypochondriacus, and Fagopyrum
esculantus; b. roasting the seeds for 2 to 15 minutes under
microwave conditions at a frequency 1500-2500 MHz, powdering the
roasted seeds to a mesh size of 50-400, and mixing the resulting
roasted seed powders to form a base product; c. obtaining powder or
extract of herbs/medicinal plants from the group of Gymnema
sylvestre, Momordica charantia, Syzgium cumini, Pterocarpus
marsupium, Trigonella foenum-graecum, Cinnamomum tamala, Withania
somnifera, Coccinia indica, Pueraria tuberosa, Asparagus racemosus,
Boerhaavia diffusa, and Aegle marmelos; d. drying the powder or
extract to obtain a residue; and e. forming the nutraceutical
product by mixing the residue with the base product, and,
optionally, adding one or more additives selected from Piper
longum, Curcuma longa, Chlorophytum tuberosum and Elettaria
cardamomum powders.
22. A process as claimed in claim 21, wherein the roasted seeds are
powdered separately to pass through sieves having mesh size ranging
from 50 to 400 mesh.
23. A process as claimed in claim 21, wherein the amount of roasted
seed powders used in the nutraceutical product is in the range
between 50 to 90% by weight.
24. A process as claimed in claim 21, wherein the roasted seed
powders comprise legumes in the range 30 to 80% by wt, cereal in
the range 5 to 40% by wt, and pseudocerels in the range 10 to 30%
by wt.
25. A process as claimed in claim 21, wherein the roasted seed
powders are mixed in various proportions ranging up to 80% by
wt.
26. A process as claimed in claim 21, wherein the plant parts used
are selected from roots, fruits, seeds, leaves, wood and whole
plant of herbs/medicinal plants ranging up to 40% by wt. are
selected for use in the nutraceutical product.
27. A process as claimed in claim 21, wherein the herbs/medicinal
plants powder is prepared by cutting the plants into small pieces
ranging from 1 to 15 cm, drying the pieces under shade at the
temperature ranging from 20 to 50.degree. C., and powdering the
dried pieces to powder ranging from 10 to 400 mesh.
28. A process as claimed in claim 21, wherein the herbs/medicinal
plants comprise to 40% by wt. of the nutraceutical product.
29. A process as claimed in claim 21, wherein the powdered
herbs/medicinal plants mixture is extracted with an aqueous alcohol
solvent in the range of 5 to 95% v/v thrice for 5 to 48 hours, at
temperature ranging from 20 to 50.degree. C.
30. A process as claimed in claim 29, wherein the alcohol is
selected from methanol, ethanol, propanol, isopropanol and
butanol.
31. A process as claimed in claim 29, wherein said solvent from
combined extractives is removed under reduced pressure ranging from
10 to 150 PSI at temperature ranging from 20 to 80.degree. C. and
the viscous residue thus obtained is called as plants extract.
32. A process as claimed in claim 31, wherein the plants extract is
suspended in water-ethanol mixture from 0 to 90% v/v in the ratio
ranging from 10 to 30% by wt. by stirring for 5 to 60 minutes.
33. A process as claimed in claim 32, wherein the suspension of
plants extract or plants powders are mixed with roasted seeds
powder mixture in the ratio ranging up to 50% by wt.
34. A process as claimed in claim 21, wherein the base product and
the residue are mixed thoroughly in a mixer grinder for a period of
ranging from 5 to 60 minutes.
35. A process as claimed in claim 21, wherein the mixture is dried
for a period of ranging from 5 to 50 hours at temperature ranging
from 20 to 50.degree. C.
36. A process as claimed in claim 21, wherein the amount of
additives added is Piper longum fruits powder 0.5 to 4.0% by wt,
Curcuma longa rhizomes powder 0 to 4.0% by wt, Chlorophytum
tuberosum rhizomes powder 0 to 4.0% by wt, and Elettaria cardamomum
fruits powder 0 to 4.0% by weight.
37. A process as claimed in claim 21, wherein the mixture
comprising the base product and the residue is again mixed
thoroughly in a mixer grinder for a period of ranging from 5 to 60
minutes and the powder thus obtained is used to prepare the
nutraceutical product.
38. A process as claimed in claim 21, wherein said dried plants
extract or plants powders and seeds powders mixture is mixed with
in the ratio ranging up to 90% by wt.
39. A process as claimed in claim 21, wherein up to 4.0% by weight
of Piper longum fruits powder is added.
40. A process as claimed in claim 21, wherein up to 4.0% by wt.
Curcuma longa rhizomes powder is added.
41. A process as claimed in claim 21, wherein up to 4.0% by wt.
Elettaria cardamomum powder is added.
42. A process as claimed in claim 21, wherein the residue, the base
product, and the Piper longum fruits powder, Curcuma longa rhizomes
powder, Chlorophytum tuberosum rhizomes powder, and Elettaria
cardamizomum fruits powder mixture is mixed thoroughly in a mixer
grinder for a period of ranging from 5 to 60 minutes to form the
nutraceutical product.
43. A process as claimed in claim 21, wherein the nutraceutical
product is suitable for use in the form of powder, granules,
biscuits, suspension, tablets or capsules etc for diabetics.
44. A process for ameliorating the general health of diabetics, the
process comprising the step of administrating a herbal
nutraceutical formulation to a diabetic, the herbal nutraceutical
formulation consisting essentially of: 50-90% by wt. of seed
products selected from the group consisting of legumes, cereals,
and pseudocereals; and 10-50% by wt of a plant product composition
consisting of herbs and medicinal plants, wherein the plant product
composition consists essentially of 2-40% by wt. Gymnema sylvestre,
2-40% by wt. Momordica charantia, 2-40% by wt. Syzgium cumini,
2-40% by wt. Pterocarpus marsupium, 2-40% by wt. Trigonella
foenum-graecum, 2-40% by wt. Cinnamomum tamala, 0-20% by wt.
Withania somnifera, 0-20% by wt. Coccinia indica, 0-20% by wt.
Pueraria tuberosa, 0-20% by wt. Asparagus recemosus, 0-20% by wt.
Boeraavia diffusa, 0-20% by wt. Aegle marmelos, and, optionally,
acceptable amounts of additives selected from the group consisting
of Piper longum, Chlorophytum tuberosum, Curcuma longa, and
Elettaria cardamomum; whereby the general health of the diabetic is
ameliorated.
45. A process as claimed in claim 44, wherein the legumes are
selected from the group consisting of Glycine max, Cicer arietinum,
Phaseolus mungo, Cyamompsis tetragonoloba, and mixtures
thereof.
46. A process as claimed in claim 44, wherein the cereal is Hordeum
vulgare.
47. A process as claimed in claim 44, wherein the pseudocereals are
selected from the group consisting of Amaranthus hypochondriacus
and Fagopyrum esculantum.
48. A process as claimed in claim 44, wherein said plant product
composition contains the additives selected from the group
consisting of Piper longum, Chlorophytum tuberosum, Curcuma longa,
and Elettaria cardamomum.
49. A process as claimed in claim 44, wherein the legume is Cicer
arietnum and the pseudocereal is Fagopyrum esculantum.
50. A process as claimed in claim 44, wherein said seed products
comprise 30-80% by wt. legumes, 5-40% by wt. cereals, and 10-30% by
wt. pseudocereals.
Description
[0001] This application is a divisional application of U.S. patent
application Ser. No. 10/108,095, filed Mar. 26, 2002, and allowed
Oct. 4, 2005
FIELD OF THE INVENTION
[0002] The present invention relates to herbal nutraceutical
formulations to ameliorate the general health of diabetics.
BACKGROUND OF THE INVENTION:
[0003] The nutraceutical food or parts of food may provide medical
health benefits including the prevention and or treatment of
diseases. Nutraceuticals, are foods or bioactive ingredients in
foods that protect or promote health whether delivered in raw
agricultural commodities, processed foods, dietary supplements,
extracts, beverages or other products and occurs at the
intersection of food and pharmaceutical industries. The development
of next generation nutraceutical "super foods" or products consist
value-addition in the traditional natural diets. Their ingredients
have tremendous impact on the health care system and may provide
medical health benefits including the prevention and or treatment
of diseases. Nutraceuticals have potential to be used as food
supplement, preventive medicine and the growing evidence points in
the direction that certain foods fight and or prevent against
diseases.
[0004] The word Nutraceuticals combine `nutrition` and
`pharmaceuticals` to mean that they can be used as preventive drugs
or food supplements. The entire concept is based on the disease
preventing/treating phytonutrients present in foodstuffs of the
diet in combating diseases e.g. phytosterols compete with dietary
cholesterol for uptake in intestine thereby blocking cholesterol
absorption into the body and can also prevent the development of
tumor in breast and prostate glands. Phenols a large group of
phytonutrients, have profound importance in preventive medicine.
Phytochemicals can enhance the efficacy of vitamin C, can also act
against allergies, ulcers, tumors, platelet aggregation,
controlling hypertension and reduce the risk of estrogen induced
cancer.
[0005] The food plays significant role in the general health of
diabetics, heart, nerves and aged. The right foods do have the
power to heal, keeping good health of body functions, ageing,
rejuvenating, immuno-modulating and prevention against diseases,
just as the wrong foods can cause sickness, rapid ageing and
premature death.
DESCRIPTION OF THE PRIOR ART
[0006] Reference is made to a book by Balch P A & Balch J F (Rx
Prescription for Dietary Wellness, 1993, USA) wherein importance of
phytochemicals, protease inhibitors from legumes against tumor
growth and ability to block natural carcinogens from forming tumors
have been mentioned. Whole grains, germinated seeds, legumes and
herbs are basically powerful foods. Reference is made to books by
Guha Bakshi D N, Sensarma P & Pal D C (A Lexicon of Medicinal
Plants in India, Naya Prokash, 1999, Calcutta, India); Chopra R N,
Nayar S L, & Chopra I C (Glossary of Indian Medicinal Plants,
NISCOM, CSIR, New Delhi, India 1999); Anonymous (Wealth of India,
Raw Materials, CSIR, New Delhi, India) and a chapter Seed Proteins
by Prakash D (Current Concepts in Seed Biology K G Mukeiji et al.
Eds 1993); published research articles by Misra P S, Prakash D,
Pandey R M & Pal M, Fitoterapia 56: 318-320, 1985; Prakash D,
Narayan P & Misra P S, Plant Foods Hum. Nutr. 36: 341-344,
1987; Prakash D & Pal M, J. Sci. Food Agric. 58: 145-147, 1992;
Prakash D, Joshi B D & Pal M, Int. J. Food Sci. Nutr. 46:
47-51, 1995; Prakash D, Niranjan A & Tewari S K Int. J. Food
Sci. Nutr. 52: 79-82, 2001) wherein the significant nutritional
composition, traditional medicinal and pharmaceutical uses of
soybean (Glycine max), chick-pea (Cicer arietinum),
black-gram/`Urd` (Phaseolus mungo), `Guar` (Cyamopsis
tetragonoloba), `Kewanch` (Mucuna pruriens), barley (Hordeum
vulgare), amaranth (Amaranthus hypochondriacus) and buckwheat
(Fagopyrum esculantus) have been described. Their seeds are being
used as edible foods in the form of different kind of preparations
without fortification with herbs/medicinal plants. Reference is
made to books by Chaudhri R D (Herbal Drugs Industry, Eastern
Publishers, 1996, New Delhi); Guha Bakshi D N, Sensarma P & Pal
D C (A Lexicon of Medicinal Plants in India, Naya Prokash, 1999,
Calcutta, India); Chopra R N, Nayar S L, & Chopra I C (Glossary
of Indian Medicinal Plants, NISCOM, CSTR, New Delhi, India 1999);
Kapoor L D (Handbook of Ayurvedic Medicinal Plants, CRC Press,
Florida, 1990); Sharma P V (Dravyaguna Vijnana, Vol II, 1992,
Chaukhambha Bharati Academy, Varanasi); Balch P A & Balch J F
(Rx Prescription for Dietary Wellness, 1993, USA) and Anonymous
(Wealth of India, Raw Materials, CSIR, New Delhi, India) wherein
the traditional and modern medicinal uses of the herbs/medicinal
plants like Gymnema sylvestre, Momordica charantia, Syzgium cumini,
Pterocarpus marsupium, Trigonella foenum-graecum, Cinnamomum
tamala, Withania somnifera, Coccinia indica, Pueraria tuberosa,
Asparagus racemosus, Boerhaavia diffusa, Aegle marmelos, Piper
longum, Chlorophytum tuberosum, Curcuma longa and Elettaria
cardamomum have been mentioned. These herbs/medicinal plants are
being used for the preparation of different kind of medicines alone
or in different combinations/formulations.
[0007] A number of patents have been granted on nutraceuticals,
which comprises either a single or a mixture of several
phytonutrients in various concentrations. In some cases, the
products were even fortified with synthetic ingredients also.
Reference is made to patents (Patent No. AU2557899; WO9935917)
wherein methods of infusing phytochemicals, nutraceuticals and
other compositions into food products e.g. juices, fruits,
vegetables and meats, etc through osmotic dehydration are
described. The methods are tedious including the use of some
chemicals during the preparation. Reference is made to patents
(Patent No. AU4777100; WO0064282) wherein nutraceuticals and
ingredients for functional foods are prepared by co-spray drying
using fructans, fructooligosaccharides instead of maltodextrins as
a drying agent and ingredients such as flavonoids, anthocyanins,
resveratrol. The main emphasis has been limited to phenolic
phytochemicals and products are in the form of a gel or cream,
showing fat like texture, which can only be used as spreader.
Reference is made to patents (Patent No. AU4038800; WO0057726)
wherein nutraceuticals comprising a blend of
N-[N-(3,3-dimethylbutyl)-L-alpha-aspartyl]-L-phenylalanine 1-methyl
ester (neotame) with another sweetener has been mentioned. The
compounds used are synthetic and have limited importance only as
sweetener or flavor modifier in nutraceuticals. Neotame is a
synthetic variation of aspartame and poses potential major health
problems like incidents of grand mal seizures, brain tumors and
environmental hazards. Reference is made to patents (Patent No.
U.S. Pat. No. 6,087,353; AU3696599; WO9959421) wherein esterified
and subsequently hydrogenated phytosterol composition for use alone
or for incorporation into foods, beverages, pharmaceuticals and
nutraceuticals have been described. The isolated phytosterols from
plants have been modified by chemical process of esterification for
the physical characteristics. Reference is made to patent (Patent
No. U.S. Pat. No. 6,099,867) wherein a nutraceutical composition
comprising water insoluble or water soluble antler powder or a
combination and method of producing the same has been described.
The products are non-ecofriendly of animal origin with limited
nutraceutical importance. Reference is made to patent (Patent No.
U.S. Pat. No. 6,093,403) wherein sugar imbalance and diabetes
treating herbal formulation in lectin prepared from Chinese herbs
has been described. The formulation has been reported to lower the
blood glucose and insulin levels but without nutraceutical benefits
in NIDDM.
[0008] The use of plant extracts and derivatives of plants for
healing and prevention purposes has been described extensively in
traditional and folk medicine literature. Over the centuries,
plants have served as a major source of medicines for treating and
prevention of diseases of mankind. Although recently the ability
for synthesis and design of new medicines has provided new pathways
for the development of therapeutic drugs, however, phytomedicines
derived from plants still hold strong position. Indigenous foods in
the treatment of diabetes mellitus have been described by G
Subbulakshmi & Mridula Naik (SNDT Women's University, Mumbai,
Internet). For centuries, specific plants, their extracts or
mixtures thereof have been used for treatment of illnesses in
Indian system of medicine and many of them have been documented as
having clinical effectiveness in treating illnesses. The plants
like Alfalfa, Aloe vera, Burdock, Celery, Comsilk, Damiana,
Elecampane, Eucalyptus, Fenugreek, Garlic, Ginger, Ginseng, Panax,
Juniper, Marshmallow, Myrrh, Nettle, Sage, Tansy have been reported
as hypoglycemic herbal ingredients (Internet). Commercial products
with branded names such as Pancreas Formula, Eleotin, Ayubes,
Diabetes Hypoglucose Capsules, Pearl Hypoglycemic Capsules,
Tongyitang Diabetes Angle Hypoglycemic Capsules, Zhen Qi Capsules
are available in internationational market on internet. In India
commercial products available in market are Cogent-db, Diabyog
Capsules, Diabyog Granules, Diabecon, Madhu Mehari Granules, Madhu
Sunya and Madhumeh Amrit etc. Most of the products (a list given in
Table 1) are a mixture of herbs/medicinal plants, minerals, and
bhasams (ashes) without a suitable balanced nutritional composition
to ameliorate the general health of diabetics and none of them is a
nutraceutical. Nutraceuticals with different branded names are
commercially available in international (Internet) and Indian
market. Besides the natural ingredients majority of the products
also contains some synthetic ingredients and recommended as food
supplement for nutrition only. While, the present invention
provides a process for the preparation of nutraceuticals with
specific combination of edible legumes, cereals, pseudocereals for
natural nutrients and herbs/medicinal plants with significant
medicinal values to provide optimum balanced nutrition and general
health protective, promotive and disease preventive benefits to the
diabetics. To the best of the Applicant's knowledge no
nutraceutical comprising a combination of legumes, cereals,
pseudocereals fortified with herbs/medicinal plants used in the
present invention or a process for the preparation of the same
exist for diabetic patients.
[0009] A literature survey and internet screening revealed that
nutraceuticals comprising a proper combination of natural edible
seeds, herbs and medicinal plants has not yet been prepared to
provide adequate nutrition and health protective benefits to the
diabetics.
OBJECTS OF THE INVENTION
[0010] The main object of the present invention relates to the
custom made tailored nutraceutical functional food composition(s),
in a proper combination of natural edible seeds, herbs/ medicinal
plants to provide optimum nutrition, health protective, promotive
and disease preventive benefits for diabetic patients.
[0011] Another object of the present invention is to provide an
herbal health protective nutraceutical formulation, which obviates
the drawbacks as detailed above.
[0012] Yet another object of the present invention is to formulate
a combination of edible legumes, cereals, pseudocereals with
promising potential for the development of base material to provide
essential natural nutrients.
[0013] Still another object of the present invention is to develop
health protective and disease preventive nutraceutical formulation,
to ameliorate the general health of diabetics, as food supplements
with specific functional attributes by fortifying nutritional base
material with herbs/medicinal plants.
SUMMARY OF THE INVENTION
[0014] The present invention relates to the custom-made
nutraceutical functional food composition(s), in a proper
combination of natural edible seeds, herbs/medicinal plants to
provide optimum nutrition, health protective, preventive and
promotive benefits to ameliorate the general health of
diabetics.
DETAILED DESCRIPTION
[0015] Accordingly, the present invention provides a herbal health
protective, promotive and disease preventive nutraceutical
composition(s) useful as food supplement to ameliorate the general
health of people having diabetics with optimum nutrients and also
help to control the blood sugar level, wherein the said
formulation(s) comprising seed products selected from the group
consisting of legumes, cereals and pseudocereals ranging from
50-90% by wt. and herbs/medicinal plants product ranging between
10-50% by wt.
[0016] Also, the present invention provide composition(s) used as
herbal health protective, promotive nutraceutical formulation(s)
for diabetics, said composition(s) comprising roasted seed powders,
herbs/medicinal plants extract Piper longum (Pippali) fruits
powder, Curcuma longa (Haldi) rhizomes powder, Chlorophytum
tuberosum (Safed Musli) rhizomes powder and Elettaria cardamomum
fruits powder.
[0017] The present invention also provide a process for the
preparation of herbal health protective, promotive and disease
preventive nutraceutical composition(s) useful as food supplement
to ameliorate the general health of diabetics with optimum
nutrients and also helps to control the blood sugar.
[0018] The process comprises the selected seeds of Glycine max,
Cicer arietinum, Phaseolus mungo, Cyamompsis tetragonoloba,
Phaseolus radiatus, Mucuna pruriens, Hordeum vulgare, Amaranthus
hypochondriacus and Fagopyrum esculantum may be roasted by keeping
in microwave oven (BPL-Sanyo, model BMO 800TS, frequency 2450 MHz)
from 2 to 15 minutes, the roasted seeds 9 in numbers may be
powdered separately to pass through a sieve ranging from 50 to 400
mesh, the seed powders may be mixed ranging from 0 to 90% by weight
to get the base product(s), in a mixer grinder ranging from 5 to 60
minutes and may be called as base product(s), the roots, fruits,
seeds, leaves, wood and whole plant of natural authentic
herbs/medicinal plants may be selected from the group of Gymnema
sylvestre, Momordica charantia, Syzgium cumini, Pterocarpus
marsupium, Trigonella foenum-graecum, Cinnamomum tamala, Withania
somnifera, Coccinia indica, Pueraria tuberosa, Asparagus racemosus,
Boerhaavia diffusa, Aegle marmelos, Piper longum, Curcuma longa,
Chlorophytum tuberosum, Elettaria cardamomum, may be cut into small
pieces 1 to 15 cm, dried under shade at the temperature ranging
from 20 to 50.degree. C. and powdered ranging from 10 to 400 mesh,
the powdered herbs/medicinal plants may be mixed ranging from 0 to
40% by wt. of the total mixture and may be extracted with aqueous
alcohol in the range of 5 to 95% v/v thrice for 5 to 48 hours, at
temperature ranging from 20 to 50.degree. C., the alcohol may be
selected from methanol, ethanol, propanol, isopropanol and butanol,
the said solvent from combined extracts may be removed under
reduced pressure ranging from 10 to 150 PSI at temperature ranging
from 20 to 80.degree. C. and the viscous residue thus obtained is
called as plants extract, the residue may be suspended in
ethanol-water mixture from 0 to 90% v/v in the ratio ranging from
10 to 30% by stirring for 5 to 60 minutes, the suspension of plants
extract or plants powder may be mixed with roasted seeds powder
mixture in the ratio ranging from 10 to 50% by wt., the mixture of
plants extract or plants powder and roasted seed powders are mixed
thoroughly in a mixer grinder for a period of ranging from 5 to 60
minutes, the mixture may be dried for a period of ranging from 5 to
50 hours at temperature ranging from 20 to 500 C, the amount of
optional additives used may be in the range piper longum fruits
powder 0.5 to 4% by wt, Curcuma longa rhizomes powder 0 to 4% by
wt, Chlorophytum tuberosum rhizomes powder 0 to 4% by wt and
Elettaria cardamomum fruits powder 0 to 4% by wt, the dried plants
extract or plants powder and seeds powder mixture is again mixed
thoroughly in a mixer grinder for a period of ranging from 5 to 60
minutes and the powder thus obtained is used to prepare final
nutraceutical(s), the end product(s) is suitable for use in the
form of powder, granules, biscuits, suspension, tablets or capsules
etc for diabetics. It was observed that the seeds selected from the
group of Glycine max, Cicer arietinum, Phaseolus mungo, Cyamompsis
tetragonoloba and Hordeum vulgare are essential, Phaseolus
radiatus, Mucuna pruriens, Amaranthus hypochondriacus and Fagopyrum
esculantum are optional. Among the herbs/medicinal plants selected
from the group of Gymnema sylvestre, Momordica charantia, Syzgium
cumini, Pterocarpus marsupium, Trigonella foenum-graecum and
Cinnamomum tamala, are essential from the group comprising Withania
somnifera, Coccinia indica, Pueraria tuberosa, Asparagus racemosus,
Boerhaavia diffusa and Aegle marmelos are optional and selected
from Piper longum, Chlorophytum tuberosum, Curcuma longa and
Elettaria cardamomum are additional components of the value
addition. The combination of the present nutraceutical(s) is not a
mere admixture of the ingredients used resulting in aggregation of
their properties but a mixture having synergistically enhanced
properties useful as food supplement as health protective,
promotive and disease preventive nutraceutical composition(s) to
ameliorate the general health of diabetics with optimum nutrients
and also help to control the blood sugar level.
[0019] In an embodiment of the invention to provide a herbal health
protective, promotive and disease preventive nutraceutical herbal
formulation(s) for diabetics and a process for preparing the same,
wherein the said formulation(s) comprising seed products selected
from the group consisting of legumes, cereals and pseudocereals
ranging from 50-90% by wt. and herbs/medicinal plants product(s)
ranging between 10-50% by wt.
[0020] In another embodiment of the invention, the seed products
are selected from dried seeds, roasted seeds and powdered
seeds.
[0021] In another embodiment of the invention, the legumes used
is/are selected from the essential group comprising Glycine max,
Cicer arietinum, Phaseolus mungo and Cyamompsis tetragonoloba and
optionally selected from the group comprising, Phaseolus radiatus
and Mucuna pruriens.
[0022] In still another embodiment of the invention, the total
amount of legumes used is in the range from 30-80% by wt.
[0023] In another embodiment of the invention, the essential cereal
used is Hordeum vulgare.
[0024] Yet another embodiment of the invention, the total amount of
cereals used is in the range from 5-40% by wt.
[0025] In another embodiment of the invention, the pseudocereals
used is/are selected from Amaranthus hypochondriacus and Fagopyrum
esculantum.
[0026] Yet another embodiment of the invention, the total amount of
pseudocereal used is in the range from 10-30% by wt.
[0027] Yet another embodiment of the invention, the essential
herbs/medicinal plants used are selected from the group of Gymnema
sylvestre, Momordica charantia, Syzgium cumini, Pterocarpus
marsupium, Trigonellafoenum-graecum and Cinnamomum tamala.
[0028] Yet another embodiment of the invention, the optional
herbs/medicinal plants used are selected from the group comprising
Withania somnifera, Coccinia indica, Pueraria tuberosa, Asparagus
racemosus, Boerhaavia diffusa and Aegle marmelos.
[0029] Yet another embodiment of the invention, the said
herbs/medicinal plant parts used are selected from roots, fruits,
seeds, leaves, wood and whole plants.
[0030] Yet another embodiment of the invention, the total amount of
herbs/medicinal plants used is X, wherein, X is in the range
between 10 to 50% by wt of formulation(s).
[0031] Yet another embodiment of the invention, relates to the
amount of the essential herbs/medicinal plants used are in the
range between Gymnema sylvestre X (2-40% by wt.), Momordica
charantia X (2-40% by wt.), Syzgium cumini X (2-40% by wt.),
Pterocarpus marsupium X (2-40% by wt.), Trigonella foenum-graecum X
(2-40% by wt.) and Cinnamomum tamala X (2-40% by wt.).
[0032] Yet another embodiment of the invention, the amount of the
optional herbs/medicinal plants used are in the range between
Withania somnifera X (0-20% by wt.), Coccinia indica X (0-20% by
wt.), Pueraria tuberosa X (0-20% by wt.), Asparagus racemosus X
(0-20% by wt.), Boerhaavia diffusa X (0-20% by wt.) and Aegle
marmelos X (0-20% by wt.).
[0033] Yet another embodiment of the invention, the said herbal
formulation optionally contain acceptable amounts of further
additives selected from Piper longum, Chlorophytum tuberosum,
Curcuma longa and Elettaria cardamomum.
[0034] One more embodiment of the invention relates to a herbal
health protective, promotive and disease preventive
nutraceutical(s) composition for diabetics, wherein the said
formulation(s) consisting of seed powders mixture ranging from 50
to 90% by wt., herbs/medicinal plants powder or their extract
ranging from 10 to 50% by wt. and the composition further
comprising Piper longum fruits powder ranging from 0.5 to 4% by
wt., Curcuma longa rhizomes powder ranging from 0 to 4% by wt.,
Chlorophytum tuberosum rhizomes powder ranging from 0 to 4% by wt.
and Elettaria cardamomum fruits powder ranging from 0 to 4% by
wt.
[0035] In yet another embodiment of the invention, the amount of
legumes present in the composition(s) is in the range between
30-80% by wt., cereals in the range between 5-40% by wt. and
psuedocereals in the range between 10-30% by wt. of the total seed
powders mixture.
[0036] In yet another embodiment of the invention, the
end-product(s) is suitable for use in the form of powder, granules,
suspension, biscuits, tablets or capsules etc.
[0037] One more embodiment of the invention, relates to a process
for the preparation of herbal health protective, promotive and
preventive nutraceutical composition(s) useful as food supplements
to ameliorate the general health of diabetics with optimum
nutrients and also help to control the blood sugar level and
disease related problems, the said process comprising: [0038] a.
selecting seed products from the group of Glycine max, Cicer
arietinum, Phaseolus mungo, P. radiatus, Cyamopsis tetragonoloba,
Mucuna pruriens, Hordeum vulgare, Amaranthus hypochondriacus,
Fagopyrum esculantum and [0039] b. roasting the seeds for 2 to 15
minutes under microwave conditions having frequency 1500-2500 MHz,
powdering the roasted seeds to a mesh size of 50-400 and mixing the
seed powders, [0040] c. obtaining powder or extract of
herbs/medicinal plants from the group of Gymnema sylvestre,
Momordica charantia, Syzgium cumini, Pterocarpus marsupium,
Trigonella foenum-graecum, Cinnamomum tamala, Withania somnifera,
Coccinia indica, Pueraria tuberosa, Asparagus racemosus, Boerhaavia
diffusa and Aegle marmelos, [0041] d. and drying the extract to
obtain a residue, mixing the plants extract residue with the base
product to get the final nutraceutical product(s) [0042] e. and
optionally adding some additives selected from piper longum,
Curcuma longa, Chlorophytum tuberosum and Elettaria cardamomum
(Elaichi) fruits powder to obtain end nutraceutical product(s).
[0043] In another embodiment of the invention, the roasted seeds
are powdered separately to pass through sieves having mesh size
ranging from 50 to 400.
[0044] In another embodiment of the invention, the amount of
roasted seed powders are mixed in various proportions ranging up to
40% by weight and parts of plants used are selected from roots,
fruits, seeds, leaves, wood and whole plant of herbs/medicinal
plants ranging up to 40% by wt. are selected for use in the
nutraceutical product(s).
[0045] In yet another embodiment of the invention, the
herbs/medicinal plants are cut into small pieces ranging from 1 to
15 cm, dried under shade at the temperature ranging from 20 to 500
C and powdered ranging from 10 to 400 mesh.
[0046] In yet another embodiment of the invention, the crushed and
powdered herbs/medicinal plants are mixed up to 40% by wt. of the
total mixture.
[0047] In yet another embodiment of the invention, the powdered
herbs/medicinal plants mixture is extracted with aqueous alcohol in
the range of 5 to 95% v/v thrice for 5 to 48 hours, at temperature
ranging from 20 to 50.degree. C.
[0048] In yet another embodiment of the invention, the alcohol is
selected from methanol, ethanol, propanol, isopropanol and
butanol.
[0049] In yet another embodiment of the invention, the said solvent
from combined extractives is removed under reduced pressure ranging
from 10 to 150 PSI at temperature ranging from 20 to 80.degree. C.
and the viscous residue thus obtained is called as plants
extract.
[0050] In yet another embodiment of the invention, the plants
extract is suspended in ethanol-water mixture from 0 to 90% v/v in
the ratio ranging from 10 to 30% by stirring for 5 to 60
minutes.
[0051] In yet another embodiment of the invention, the suspension
of plants extract or plants powder is mixed with roasted seed
powders mixture in the ratio ranging up to 50% by wt.
[0052] In yet another embodiment of the invention, the mixture of
plants extract or plants powder and roasted seed powders are mixed
thoroughly in a mixer grinder for a period of ranging from 5 to 60
minutes.
[0053] In yet another embodiment of the invention, the mixture is
dried for a period of ranging from 5 to 50 hours at temperature
ranging from 20 to 50.degree. C.
[0054] In yet another embodiment of the invention, the amount of
optional additives used are in the range Piper longum fruits powder
0.5 to 4% by wt, Curcuma longa rhizomes powder 0 to 4% by wt,
Chlorophytum tuberosum rhizomes powder 0 to 4% by wt and Elettaria
cardamomum fruits powder 0 to 4% by wt.
[0055] In yet another embodiment of the invention, the dried plants
extract or plants powder and seed powders mixture is again mixed
thoroughly in a mixer grinder for a period of ranging from 5 to 60
minutes and the powder thus obtained is used to prepare final
nutraceutical(s).
[0056] In yet another embodiment of the invention, the said dried
plants extract or plants powder and seed powders mixture is mixed
with in the ratio ranging up to 90% by wt.
[0057] In yet another embodiment of the invention, said mixture
containing dried and powdered mixture of plants extract or powders
thereof, roasted seed powders and Piper longum fruits powder up to
4% by wt is added to the said mixture.
[0058] In yet another embodiment of the invention, Curcuma longa
rhizomes powder up to 4% by wt is added to the said mixture.
[0059] In yet another embodiment of the invention, to the said
mixture up to 4% by wt. Elettaria cardamomum seeds powder is
added.
[0060] In yet another embodiment of the invention, powdered,
mixture of plants extract or plants powder, roasted seed powders,
Piper longum fruits powder, Curcuma longa rhizomes powder,
Chlorophytum tuberosum rhizomes powder and Elettaria cardamomum
fruits powder mixture is mixed thoroughly in a mixer grinder for a
period of ranging from 5 to 60 minutes to get the final
nutraceutical product(s).
[0061] In yet another embodiment of the invention, the
nutraceutical formulations, as herein described for the
composition, methodology, preparation of base material for
nutrition and fortified with selected herbs/medicinal plants in the
form of powders/extracts to get the value added end nutraceutical
product(s) which may be used as health protective, promotive, food
supplements to ameliorate the general health of the diabetics and
to control hyperglycemia in the form of powder, granules, biscuits,
suspension, tablets or capsules etc.
Novelty:
[0062] The novelty of present invention is the specific combination
of legumes, cereals, pseudocereals fortified with herbs/medicinal
plants and the process for the preparation of nutraceuticals. The
nutraceuticals are with optimum nutrition, non toxic, natural
herbal plant products, easy to digest, have health protective and
promotive properties to ameliorate the health and vigor of
diabetics.
[0063] Besides controlling the blood/urine sugar level the
nutraceutical product(s) provide additional benefits in diabetese
related human health problems like reduction in fatigue, weakness,
drowsiness, numbing effect, frequent urination, unusual thirst and
hunger, weight loss, swellings on legs/ankles, burning sensation on
feet, palms, relief in skin itching, skin dryness, black patches on
skin, hypertension, increase in sleep comfort, energetic feeling,
improvement in laziness, blurred vision, frequent skin infections
and slow healing of wounds and sores. A 10-30% reduction in insulin
doses was also observed after 6-8 weeks in IDDM adult diabetics and
30 to 100% reduction of oral medicines in NIDDM adult diabetics was
found.
[0064] The present invention provides a process, without
deteriorating the nutritional and pharmaceutical properties of the
basic ingredients, for the preparation of custom-made herbal health
protective nutraceutical(s) suitable as a nutraceutical food
supplement for diabetics.
[0065] The present invention provides formulation(s) for the
combination of edible legumes, cereals, pseudocereals with
promising potential for the development of well balanced
nutritional base material.
[0066] The present invention provides value added products with
synergistic health promotive, protective and disease preventive
effects of natural herbs/medicinal plants to get specifically
designed nutraceutical(s) for well balanced natural nutrients, to
get optimum nutrition to ameliorate the general health of
diabetics.
Brief Description of the Accompanying Tables
[0067] Table 1 provides the composition of the Nutraceutical
formulation of the present invention and other commercial herbal
antidiabetic products
[0068] Tables 2 provides the percentage seed powders (legumes,
cereals and pseudocereals) in the composition of the present
invention.
[0069] Table 3 provides the percentage of herbs/medicinal plants in
the composition of the present invention.
[0070] Table 4 provides the trial feed back remarks from volunteers
on the nutraceutical product of the present invention.
[0071] Table 5 provides the trial feed back from volunteers after
consuming the Herbal health protective and promotive Nutraceutical
for diabetics for 3 months.
[0072] The invention is described with reference to the examples,
which are provided by way of illustration only, and these examples
should not be construed to limit the scope of the present
invention.
EXAMPLES
Specific Combinations
[0073] To prepare nutraceutical formulation the seeds of Glycine
max, Cicer arietinum, Phaseolus mungo, Cyamopsis tetragonoloba,
Mucuna pruriens, Hordeum vulgare, Amaranthus hypochondriacus and
Fagopyrum esculantum were roasted by keeping in microwave oven for
2 minutes separately. The microwave roasted seeds were powdered
separately to pass through a 50-mesh sieve. The seed powders and
herbs/medicinal plants extract were mixed as given in example
1.
Example 1
[0074] The microwave roasted seed powders of Glycine max 50 g,
Cicer arietinum 100 g, Phaseolus mungo 50 g, Cyamopsis
tetragonoloba 50 g, Mucuna pruriens 50 g, Hordeum vulgare 400 g,
Amaranthus hypochondriacus 10 g and Fagopyrum esculantum 200 g were
mixed for 20 minutes in a mixer grinder. The roots, fruits, bark,
whole plant of natural authentic herbs/medicinal plants collected
from different natural sources in India were cut into small pieces
of about 1 cm, dried under shade at 20.degree. C., crushed and
powdered to 10-mesh. The dried powder of Gymnema sylvestre 20 g,
Momordica charantia 50 g, Syzgium cumini 80 g, Pterocarpus
marsupium 50 g, Trigonella foenum-graecum 100 g and Cinnamomum
tamala 400 g, Withania somnifera 20 g, Coccinia indica 50 g,
Pueraria tuberosa 200 g and Boerhaavia diffusa 30 g were extracted
with 1.5 lit of aqueous alcohol 5% v/v thrice for 5 hours, at
temperature 20.degree. C., the solvent from combined extractives
was removed under reduced pressure at 10 PSI, at temperature of
20.degree. C. and the viscous residue thus obtained was called as
the plants extract. The 10 g of plants extract was suspended in 20
ml water and mixed with mixer grinder for a period of 5 minutes,
the suspension of plants extract was mixed with the 89.5 g mixture
of roasted seed powders and mixed thoroughly for a period of 5
minutes. The plants extract and seed powders mixture was dried for
5 hours at 20.degree. C. under vacuum, the dried plants extract and
seed powders mixture was again mixed thoroughly in a mixer grinder
for 5 minutes. The powder thus obtained was used to prepare final
nutraceutical. The dried plants extract and seed powders mixture
was mixed with the optional additives of Piper longum fruit powder
0.5 g and the total mixture was mixed thoroughly in a mixer grinder
for 5 minutes to get the final nutraceutical product. The end
product is suitable for use in the form of powder, granules,
biscuits, suspension, tablets or capsules etc for diabetics.
[0075] Tables 2 provides the percentage seed powders (legumes,
cereals and pseudocereals) in the composition of the present
invention.
[0076] Table 3 provides the percentage of herbs/medicinal plants in
the composition of the present invention.
[0077] The combination of the present nutraceutical is a mixture
having synergistic (Table 4) health protective and promotive
properties useful as food supplement to ameliorate the general
health of diabetics with optimum nutrients and also help to control
the blood sugar level (Table 5).
[0078] To prepare nutraceutical formulation the seeds of Glycine
max, Cicer arietinum, Phaseolus mungo, Cyamompsis tetragonoloba,
Mucuna pruriens, Hordeum vulgare, Amaranthus hypochondriacus and
Fagopyrum esculantum were roasted by keeping in microwave oven for
12 minutes separately. The microwave-roasted seeds were powdered
separately to pass through a 350-mesh sieve. The seed powders and
herbs/medicinal plants extract were mixed as given in example
2.
Example 2
[0079] The microwave roasted seed powders of Glycine max 150 g,
Cicer arietinum 10 g, Phaseolus mungo 50 g, Cyamompsis
tetragonoloba 100 g, Mucuna pruriens 50 g, Hordeum vulgare 350 g,
Amaranthus hypochondriacus 100 g and Fagopyrum esculantum 100 g
were mixed in a mixer grinder for 55 minutes to get the base
product. The roots, fruits, seeds, leaves, wood and whole plant of
natural authentic herbs herbs/medicinal plants collected from
different natural sources in India were cut into small pieces of
about 12 cm, dried at 45.degree. C., crushed and powdered to
350-mesh. The dried powder of Gymnema sylvestre 400 g, Momordica
charantia 50 g, Syzgium cumini 20 g, Pterocarpus marsupium 100 g,
Trigonella foenum-graecum 80 g, Cinnamomum tamala 50 g, Withania
somnifera 30 g, Asparagus racemosus 200 g, Boerhaavia difussa 20 g
and Aegle marmelos 50 g were extracted with 1.75 lit ml aqueous
alcohol 80% v/v thrice for 42 hours, at 45.degree. C., the solvent
from combined extractives was removed under reduced pressure at 125
PSI at temperature 70.degree. C. and the viscous residue thus
obtained is called as plants extract. The 20 g plants extract was
suspended in 60 ml of 80% water-ethanol mixture by stirring for 50
minutes, the suspension of plants extract was mixed with 75 g of
roasted seeds powder mixture and mixed thoroughly in a mixer
grinder for a period of 55 minutes. The mixture was dried for a
period of 45 hours at temperature 50.degree. C. The powder thus
obtained was used to prepare final nutraceutical. The dried plants
extract and seed powders mixture was mixed with the optional
additives of Piper longum fruits powder 1.0 g, Curcuma longa
rhizomes powder 1.5 g, Chlorophytum tuberosum rhizomes powder 2.0 g
and Elettaria cardamomum fruits powder 0.5 g the total mixture was
again mixed thoroughly in a mixer grinder for a period of 55
minutes to get the final nutraceutical. The end product is suitable
for use in the form of powder, granules, biscuits, suspension,
tablets or capsules etc for diabetics.
[0080] The combination of the present nutraceutical is a mixture
having synergistic (Table 4) health protective and promotive
properties useful as food supplement to ameliorate the general
health of diabetics with optimum nutrients and also help to control
the blood sugar (Table 5).
[0081] To prepare nutraceutical formulation the seeds of Glycine
max, Cicer arietinum, Phaseolus mungo, Cyamompsis tetragonoloba,
Mucuna pruriens, Hordeum vulgare, Amaranthus hypochondriacus and
Fagopyrum esculantum were roasted by keeping in microwave oven for
10 minutes separately. The microwave roasted seeds were powdered
separately to pass through a 300-mesh sieve. The seed powders and
herbs/medicinal plants extract were mixed as given in example
3.
Example 3
[0082] The microwave roasted seeds, were powdered of Glycine max
150 g, Cicer arietinum 150 g, Phaseolus mungo 100 g, Cyamompsis
tetragonoloba 50 g, Mucuna pruriens 50 g, Hordeum vulgare 300 g,
Amaranthus hypochondriacus 150 g and Fagopyrum esculantum 50 g were
mixed in a mixer grinder for 50 minutes to get the base product.
The roots, fruits, seeds, leaves, wood and whole plant of natural
authentic herbs herbs/medicinal plants collected from different
natural sources in India were cut into small pieces of about 10 cm,
dried at 40.degree. C., crushed and powdered to 300-mesh. The dried
powder of Gymnema sylvestre 20 g, Momordica charantia 80 g, Syzgium
cumini 1 00 g, Pterocarpus marsupium 150 g, Trigonella
foenum-graecum 150 g, Cinnamomum tamala 200 g, Withania somnifera
50 g, Coccinia indica 200 g, Pueraria tuberosa 30 g and Asparagus
racemosus 20 g were extracted with 1.7 ml aqueous alcohol 70% v/v
thrice for 40 hours, at 40.degree. C., the solvent from combined
extractives was removed under reduced pressure at 100 PSI at
temperature 60.degree. C. and the viscous residue thus obtained is
called as plants extract. The 25 g plants extract was suspended in
75 ml of 70% water-ethanol mixture by stirring for 45 minutes, the
suspension of plants extract was mixed with 70 g of roasted seeds
powder mixture and mixed thoroughly in a mixer grinder for a period
of 50 minutes. The mixture was dried for a period of 40 hours at
temperature 45.degree. C. The powder thus obtained was used to
prepare final nutraceutical. The dried plants extract and seed
powders mixture was mixed with the optional additives of Piper
longum fruits powder 1.0 g and Elettaria cardamomum fruits powder
4.0 g, and the total mixture was again mixed thoroughly in a mixer
grinder for a period of 45 minutes to get the final nutraceutical.
The end product is suitable for use in the form of powder,
granules, biscuits, suspension, tablets or capsules etc for
diabetics.
[0083] The combination of the present nutraceuticals is a mixture
having synergistic (Table 4) health protective and promotive
properties useful as food supplement to ameliorate the general
health of diabetics with optimum nutrients and also help to control
the blood sugar (Table 5).
[0084] To prepare nutraceutical formulation the seeds of Glycine
max, Cicer arietinum, Phaseolus mungo, Cyamompsis tetragonoloba,
Phaseolus raditus, Hordeum vulgare, Amaranthus hypochondriacus and
Fagopyrum esculantum were roasted by keeping in microwave oven for
8 minutes separately. The microwave roasted seeds were powdered
separately to pass through a 250-mesh sieve. The seed powders and
herbs/medicinal plants extract were mixed as given in example
4.
Example 4
[0085] The microwave roasted seeds, were powdered of Glycine max
200 g, Cicer arietinum 150 g, Phaseolus mungo 100 g, Cyamompsis
tetragonoloba 50 g, Phaseolus raditus 50 g, Hordeum vulgare 250 g,
Amaranthus hypochondriacus 150 g and Fagopyrum esculantum 50 g were
mixed in a mixer grinder for 45 minutes to get the base product.
The roots, fruits, seeds, leaves, wood and whole plant of natural
authentic herbs herbs/medicinal plants collected from different
natural sources in India were cut into small pieces of about 8.0
cm, dried at 35.degree. C. , crushed and powdered to 200-mesh. The
dried powder of Gymnema sylvestre 100 g, Momordica charantia 20 g,
Syzgium cumini 80 g, Pterocarpus marsupium 150 g, Trigonella
foenum-graecum 200 g, Cinnamomum tamala 150 g, Withania somnifera
200 g, Coccinia indica 20 g, Pueraria tuberosa 50 g and Asparagus
racemosus 30 g were extracted with 1.6 lit aqueous alcohol 60% v/v
thrice for 35 hours, at 38.degree. C., the solvent from combined
extractives was removed under reduced pressure at 90 PSI at
temperature 55.degree. C. and the viscous residue thus obtained is
called as plants extract. The 30 g plants extract was suspended in
90 ml of 60% water-ethanol mixture by stirring for 40 minutes, the
suspension of plants extract was mixed with 65 g of roasted seeds
powder mixture and mixed thoroughly in a mixer grinder for a period
of 45 minutes. The mixture was dried for a period of 35 hours at
temperature 40.degree. C. The powder thus obtained was used to
prepare final nutraceutical. The dried plants extract and seed
powders mixture was mixed with the optional additives of Piper
longum fruits powder 1.0 g and Chlorophytum tuberosum rhizomes
powder 4.0 g, the total mixture was again mixed thoroughly in a
mixer grinder for a period of 40 minutes to get the final
nutraceutical. The end product is suitable for use in the form of
powder, granules, biscuits, suspension, tablets or capsules etc for
diabetics.
[0086] The combination of the present nutraceuticals is a mixture
having synergistic (Table 4) health protective and promotive
properties useful as food supplement to ameliorate the general
health of diabetics with optimum nutrients and also help to control
the blood sugar (Table 5).
[0087] To prepare nutraceutical formulation the seeds of Glycine
max, Cicer arietinum, Phaseolus mungo, Cyamompsis tetragonoloba,
Phaseolus raditus, Mucuna pruriens, Hordeum vulgare, Amaranthus
hypochondriacus and Fagopyrum esculantum were roasted by keeping in
microwave oven for 6 minutes separately. The microwave roasted
seeds were powdered separately to pass through a 200-mesh sieve.
The seed powders and herbs/medicinal plants extract were mixed as
given in example 5.
Example 5
[0088] The microwave roasted seeds, were powdered of Glycine max
200 g, Cicer arietinum 100 g, Phaseolus mungo 50 g, Cyamompsis
tetragonoloba 50 g, Phaseolus raditus 100 g, Mucuna pruriens 100 g,
Hordeum vulgare 150 g, Amaranthus hypochondriacus 200 g and
Fagopyrum esculantum 50 g were mixed in a mixer grinder for 40
minutes to get the base product. The roots, fruits, seeds, leaves,
wood and whole plant of natural authentic herbs herbs/medicinal
plants collected from different natural sources in India were cut
into small pieces of about 6.0 cm , dried at 30.degree. C., crushed
and powdered to 150-mesh. The dried powder of Gymnema sylvestre 50
g, Momordica charantia 50 g, Syzgium cumini 20 g, Pterocarpus
marsupium 80 g, Trigonella foenum-graecum 400 g, Cinnamomum tamala
100 g, Coccinia indica 30 g, Asparagus racemosus 30 g, Boerhaavia
difussa 200 g and Aegle marmelos 20 g were extracted with 1.5 lit
aqueous alcohol 50% v/v thrice for 30 hours, at 35.degree. C., the
solvent from combined extractives was removed under reduced
pressure at 80 PSI at temperature 50.degree. C. and the viscous
residue thus obtained is called as plants extract. The 35 g plants
extract was suspended in 130 ml of 50% water-ethanol mixture by
stirring for 35 minutes, the suspension of plants extract was mixed
with 60 g of roasted seeds powder mixture and mixed thoroughly in a
mixer grinder for a period of 40 minutes. The mixture was dried for
a period of 30 hours at temperature 40.degree. C. The powder thus
obtained was used to prepare final nutraceutical. The dried plants
extract and seed powders mixture was mixed with the optional
additives of Piper longum fruits powder 4.0 g and Curcuma longa
rhizomes powder 1.0 g, the total mixture was again mixed thoroughly
in a mixer grinder for a period of 35 minutes to get the final
nutraceutical. The end product is suitable for use in the form of
powder, granules, biscuits, suspension, tablets or capsules etc for
diabetics.
[0089] The combination of the present nutraceuticals is a mixture
having synergistic (Table 4) health protective and promotive
properties useful as food supplement to ameliorate the general
health of diabetics with optimum nutrients and also help to control
the blood sugar (Table 5).
[0090] To prepare nutraceutical formulation the seeds of Glycine
max, Cicer arietinum, Phaseolus mungo, Cyamompsis tetragonoloba,
Phaseolus raditus, Hordeum vulgare and Amaranthus hypochondriacus
were roasted by keeping in microwave oven for 5 minutes separately.
The microwave roasted seeds were powdered separately to pass
through a 150-mesh sieve. The seed powders and herbs/medicinal
plants extract were mixed as given in example 6.
Example 6
[0091] The microwave roasted seeds, were powdered of Glycine max
100 g, Cicer arietinum 400 g, Phaseolus mungo 30 g, Cyamompsis
tetragonoloba 20 g, Phaseolus raditus 150 g, Hordeum vulgare 150 g
and Amaranthus hypochondriacus 100 g were mixed in a mixer grinder
for 30 minutes to get the base product. The roots, fruits, seeds,
leaves, wood and whole plant of natural authentic herbs
herbs/medicinal plants collected from different natural sources in
India were cut into small pieces of about 5.0 cm, dried at
30.degree. C. , crushed and powdered to 100-mesh. The dried powder
of Gymnema sylvestre 80 g, Momordica charantia 100 g, Syzgium
cumini 50 g, Pterocarpus marsupium 400 g, Trigonella foenum-graecum
50 g, Cinnamomum tamala 20 g, Withania somnifera 10 g, Coccinia
indica 20 g, Pueraria tuberosa 20 g, Boerhaavia difussa 50 g and
Aegle marmelos 200 g were extracted with 1.25 lit aqueous alcohol
40% v/v thrice for 25 hours, at 30.degree. C., the solvent from
combined extractives was removed under reduced pressure at 70 PSI
at temperature 45.degree. C. and the viscous residue thus obtained
is called as plants extract. The 40 g plants extract was suspended
in 160 ml of 50% water-ethanol mixture by stirring for 35 minutes,
the suspension of plants extract was mixed with 55 g of roasted
seeds powder mixture and mixed thoroughly in a mixer grinder for a
period of 35 minutes. The mixture was dried for a period of 25
hours at temperature 35.degree. C. The powder thus obtained was
used to prepare final nutraceutical. The dried plants extract and
seed powders mixture was mixed with the optional additives of Piper
longum fruits powder 3.0 g, Chlorophytum tuberosum rhizomes powder
1.5 g and Elettaria cardamomum fruits powder 0.5 g, and the total
mixture was again mixed thoroughly in a mixer grinder for a period
of 30 minutes to get the final nutraceutical. The end product is
suitable for use in the form of powder, granules, biscuits,
suspension, tablets or capsules etc for diabetics.
[0092] The combination of the present nutraceuticals is a mixture
having synergistic (Table 4) health protective and promotive
properties useful as food supplement to ameliorate the general
health of diabetics with optimum nutrients and also help to control
the blood sugar (Table 5).
[0093] To prepare nutraceutical formulation the seeds of Glycine
max, Cicer arietinum, Phaseolus mungo, Cyamompsis tetragonoloba,
Hordeum vulgare and Fagopyrum esculantum were roasted by keeping in
microwave oven for 5 minutes separately. The microwave roasted
seeds were powdered separately to pass through a 150-mesh sieve.
The seed powders and herbs/medicinal plants extract were mixed as
given in example 7.
Example 7
[0094] The microwave roasted seeds, were powdered of Glycine max
250 g, Cicer arietinum 200 g, Phaseolus mungo 150 g, Cyamompsis
tetragonoloba 150 g, Hordeum vulgare 100 g and Fagopyrum esculantum
200 g were mixed in a mixer grinder for 20 minutes to get the base
product. The roots, fruits, seeds, leaves, wood and whole plant of
natural authentic herbs herbs/medicinal plants collected from
different natural sources in India were cut into small pieces of
about 3.0 cm, dried at 25.degree. C., crushed and powdered to
60-mesh. The dried powder of Gymnema sylvestre 100 g, Momordica
charantia 50 g, Syzgium cumini 400 g, Pterocarpus marsupium 20 g,
Trigonella foenum-graecum 80 g, Cinnamomum tamala 50 g, Withania
somnifera 100 g, Coccinia indica 100 g and Boerhaavia difussa 100 g
were extracted with 1.2 lit aqueous alcohol 30% v/v thrice for 20
hours, at 30.degree. C., the solvent from combined extractives was
removed under reduced pressure at 60 PSI at temperature 40.degree.
C. and the viscous residue thus obtained is called as plants
extract. The 45 g plants extract was suspended in 230 ml of 40%
water-ethanol mixture by stirring for 25 minutes, the suspension of
plants extract was mixed with 50 g of roasted seeds powder mixture
and mixed thoroughly in a mixer grinder for a period of 30 minutes.
The mixture was dried for a period of 20 hours at temperature
30.degree. C. The powder thus obtained was used to prepare final
nutraceuticals. The dried plants extract and seed powders mixture
was mixed with the optional additives of Piper longum fruits powder
1.0 g and Curcuma longa rhizomes powder 4.0 g and the total mixture
was again mixed thoroughly in a mixer grinder for a period of 20
minutes to get the final nutraceutical. The end product is suitable
for use in the form of powder, granules, biscuits, suspension,
tablets or capsules etc for diabetics.
[0095] The combination of the present nutraceuticals is a mixture
having synergistic (Table 4) health protective and promotive
properties useful as food supplement to ameliorate the general
health of diabetics with optimum nutrients and also help to control
the blood sugar (Table 5).
[0096] To prepare nutraceutical formulation the seeds of Glycine
max, Cicer arietinum, Phaseolus mungo, Cyamompsis tetragonoloba,
Hordeum vulgare, Amaranthus hypochondriacus and Fagopyrum
esculantum were roasted by keeping in microwave oven for 15 minutes
separately. The microwave roasted seeds were powdered separately to
pass through a 400-mesh sieve. The seed powders and herbs/medicinal
plants extract were mixed as given in example 8.
Example 8
[0097] The microwave roasted seeds, were powdered of Glycine max
300 g, Cicer arietinum 100 g, Phaseolus mungo 200 g, Cyamompsis
tetragonoloba 200 g, Hordeum vulgare 50 g, Amaranthus
hypochondriacus 50 g and Fagopyrum esculantum 150 g were mixed in a
mixer grinder for 60 minutes to get the base product. The roots,
fruits, seeds, leaves, wood and whole plant of natural authentic
herbs herbs/medicinal plants collected from different natural
sources in India were cut into small pieces of about 15 cm, dried
at 50.degree. C., crushed and powdered to 400-mesh. The dried
powder of Gymnema sylvestre 50 g, Momordica charantia 400 g,
Syzgium cumini 100 g, Pterocarpus marsupium 50 g, Trigonella
foenum-graecum 20 g, Cinnamomum tamala 80 g, Pueraria tuberosa 100
g, Asparagus racemosus 100 g and Aegle marmelos 100 g were
extracted with 2.0 lit aqueous alcohol 90% v/v thrice for 48 hours,
at 50.degree. C., the said solvent from combined extractives was
removed under reduced pressure at 150 PSI at temperature 80.degree.
C. and the viscous residue thus obtained is called as plants
extract. The 49.5 g plants extract was suspended in 300 ml of 90%
water-ethanol mixture by stirring for 60 minutes, the suspension of
plants extract was mixed with 50 g of roasted seeds powder mixture
and mixed thoroughly in a mixer grinder for a period of 60 minutes.
The mixture was dried for a period of 50 hours at temperature
50.degree. C. The powder thus obtained was used to prepare final
nutraceutical. The dried plants extract and seed powders mixture
was mixed with the optional additives of Piper longum fruits powder
0.5 g and the total mixture was again mixed thoroughly in a mixer
grinder for a period of 60 minutes to get the final nutraceutical.
The end product is suitable for use in the form of powder,
granules, biscuits, suspension, tablets or capsules etc for
diabetics.
[0098] The combination of the present nutraceutical(s) is a mixture
having synergistic (Table 4) health protective and promotive
properties useful as food supplement to ameliorate the general
health of diabetics with optimum nutrients and also help to control
the blood sugar (Table 5).
Advantages
[0099] Include control in blood/urine sugar levels, ameliorate
diabetes related health problems like reduction in fatigue,
weakness, drowsiness, numbing effect, frequent urination, unusual
thirst and hunger, weight loss, swellings on legs/ankles, burning
sensation on feet, palms, relief in skin itching, skin dryness,
black patches on skin, hypertension, increase in sleep comfort,
feeling more energetic, improvement in laziness, blurred vision,
frequent skin infections and slow healing of wounds and sores. A
10-30% reduction in insulin doses was also observed after 6-8 weeks
in IDDM adult diabetics and 30 to 100% reduction of oral medicines
in NIDDM adult diabetics was found. TABLE-US-00001 TABLE 1 The
composition of the present nutraceutical formulation(s)
(Nutra-Diab) and commercial herbal antidiabetic products.
Commercial herbal antidiabetic Nutraceutical formulation(s)
products Example 1: Glycine max 4.475, Cicer arietinum 8.95,
Cogent-db: Each tablet is prepared out Phaseolus mungo 4.475,
Cyamompsis tetragonoloba of Azadirecta indica bark 3 g, 4.475,
Mucuna pruriens 4.475, Hordeum vulgare 35.8, Phyllanthus emblica
0.7 g, Terminalia Amaranthus hypochondriacus 8.95, Fagopyrum
bellerica 0.7 g, T. chebula 0.7 g, esculantum 17.9, Gymnema
sylvestre 0.2, Momordica Tribulus terrestris 1.0 g, Aconitum
charantia 0.5, Syzgium cumini 0.8, Pterocarpus heterophyllum 0.1 g,
Curcuma longa marsupium 0.5, Trigonella foenum-graecum 1.0, 0.8 g,
Syzygium cumini 2.0 g, Rotula Cinnamomum tamala 4.0, Withania
somnifera 0.2, aquatica 1.0 g. Coccinia indica 0.5, Pueraria
tuberosa 2.0, Boerhaavia difussa 0.4 and Piper longum 0.5% by wt.
Example 2: Glycine max 11.25, Cicer arietinum 7.5, Diabyog
Capsules: Each capsule of Phaseolus mungo 3.75, Cyamompsis
tetragonoloba 500 mg contain Basant Kusumakar Ras 7.5, Mucuna
pruriens 3.75, Hordeum vulgare 26.25, 60 mg,Yasad Bhasam 5 mg, yang
Amaranthus hypochondriacus 7.5, Fagopyrum Bhasam 5 mg, Raj Jambu
Beej 100 mg, esculantum 7.5, Gymnema sylvestre 8.0, Momordica
Guduchi 40 mg, Sudh Shilajeet 30 mg, charantia 1.0, Syzgium cumini
0.4, Pterocarpus Meshasringi 60 mg, Shushavi Ghan 50 marsupium 2.0,
Trigonella foenum-graecum 1.6, mg, Neem Ghan 30 mg, Methi Ghan 30
Cinnamomum tamala 1.0, Withania somnifera 0.6, mg, Vijayasaar 50
mg, Goshul 20 mg, Asparagus racemosus 4.0, Boerhaavia difussa 0.4,
Punamava 20 mg. Aegle marmelos 1.0, Piper longum 1.0, Curcuma longa
1.5, Chlorophytum tuberosum 2.0 and Elettaria cardamomum 0.5% by
wt. Example 3: Glycine max 10.5, Cicer arietinum 10.5, Diabyog
Granules: Each gram contain Phaseolus mungo 7.0, Cyamompsis
tetragonoloba 3.5, Swarn Makshik Bhasam 20 mg, Mucuna pruriens 3.5,
Hordeum vulgare 21.0, Trivang Bhasam 20 mg, Shilajeet Amaranthus
hypochondriacus 10.5 Fagopyrum Shudh 60 mg, Meshasringi 60 mg,
esculantum 3.5, Gymnema sylvestre 0.5, Momordica Shushavi Ghan 50
mg, Raj Jambu Beej charantia 2.0, Syzgium cumini 2.5, Pterocarpus
100 mg, Guduchi, Arjun, Gokshus, marsupium 3.75, Trigonella
foenum-graecum 3.75, Neem, Bhumlamlabi, Raj Jambu Patra, Cinnamomum
tamala 5.0, Withania somnifera 1.25, Methini, Safed Chandan,
Punarnava, Coccinia indica 5.0, Pueraria tuberosa 0.75, Satavar
each 50 mg/g, Twak 30 mg, Asparagus racemosus 0.5, Piper longum 1.0
and Vijayasaar, Kramuka, Aguru each 3.3 Elettaria cardamomum 4.0%.
mg, Excepient Q.S. Example 4: Glycine max 13.0, Cicer arietinum
9.75, Diabecon: Extract Meshashringi Phaseolus mungo 6.5,
Cyamompsis tetragonoloba 30 mg, Pitasara 20 mg, Yashti-madhu 20
3.25, Phaseolus raditus 3.25, Hordeum vulgare 16.25, Saptarangi 20
mg, Jambu 20 Amaranthus hypochondriacus 9.75, Fagopyrum mg,
Shatavari 20 mg, Punarnava 20 mg, esculantum 3.25, Gymnema
sylvestre 3.0, Momordica Mundatika 10 mg, Guduchi 10 mg, charantia
0.6, Syzgium cumini 2.4, Pterocarpus Kairata 10 mg, Gokshura 10 mg,
marsupium 4.5, Trigonella foenum-graecum 6.0, Bhumyaamlaki 10 mg,
Gumbhari 10 mg, Cinnamomum tamala 4.5, Withania somnifera 6.0,
Karpasi 10 mg, Karpasi 10 mg, Coccinia indica 0.6, Pueraria
tuberosa 1.5, Asparagus Daruharidra 5 mg, Kumari 5 mg, racemosus
0.9, Piper longum 1.0 and Chlorophytum Triphala 3 mg, Pdrs. Guggule
(purified) tuberosum 4.0%. 30 mg, Shilajeet (purified) 30 mg,
Vidangadi lauham 27 mg, Sushavi 20 mg, Maricha 10 mg, Vishnu priya
10 mg, Atibala 10 mg, Haridra 10 mg, Abhrak bhasam 10 mg, Praval
bhasam 10 mg, Jungli palak 5 mg, yang bhasam 5 mg, Akik pisti 5 mg,
Shingraf 5 mg, Yasad bhasam 5 mg, Trikuta 5 mg.Processed in
Udumbara, Babbula puga, Ashvagandha, Tagara, Shyonaka, Chandana,
Sunthi, Jambu. Example 5: Glycine max 12.0, Cicer arietinum 6.0,
Madhu Mehari Granules: Gymnema Phaseolus mungo 3.0, Cyamompsis
tetragonoloba 3.0, sylsylvestra 10%, Syzygium cumini Phaseolus
raditus 6.0, Mucuna pruriens 6.0, Hordeum 10%, Memordica charantia
10%, vulgare 9.0, Amaranthus hypochondriacus 12.0, Tinosphora
cordifolia 10%, Acacia Fagopyrum esculantum 3.0, Gymnema sylvestre
1.75, catechu 5%, Emblica officinalis 10%, Momordica charantia
1.75, Syzgium cumini 0.7, Pterocarpus marsupium 5%, Ficus
Pterocarpus marsupium 2.8, Trigonella foenum- racemosa 5%,
Picrorhiza kurroa 5%, graecum 14.0, Cinnamomum tamala 3.5, Coccinia
Trigonella foenum-graecum 5%, indica 1.05 , Asparagus racemosus
1.75, Boerhaavia Asphaltum punjabinum 10%, Trivang difussa 7.0,
Aegle marmelos 0.7, Piper longum 4.0 Bhasm 2%, Abhrak Bhasm 2%,
Swam and Curcuma longa 1.0%. Makshik Bhasm 2%, Excepient starch-
lactose 4% w/w. Example 6: Glycine max 5.5, Cicer arietinum 22.0,
Madhu Sunva: Each Kg contain Phaseolus mungo 1.65, Cyamompsis
tetragonoloba 1.1, Gudmar Fali 150 g, Jamun Seed 150 g, Phaseolus
raditus 8.2, Hordeum vulgare 11.0, Karela Seed, 100 g, Kundru Root
100 g, Amaranthus hypochondriacus 5.5, Gymnema sylvestre Asgandha
100 g, Pure Shilajeet 10 g, 3.2, Momordica charantia 4.0, Syzgium
cumini 2.0, Gurhal Pushp 50 g, Tulsi Root 90 g, Pterocarpus
marsupium 16.0, Trigonella foenum- Vijayasaar Wood 150 g. graecum
2.0, Cinnamomum tamala 0.8, Withania somnifera 0.4, Coccinia indica
0.8, Pueraria tuberosa 0.8, Boerhaavia difussa 2.0, Aegle marmelos
8.0, Piper longum 3.0, Chlorophytum tuberosum 1.5 and Elettaria
cardamomum 0.5%. Example 7: Glycine max 12.5, Cicer arietinum 10.0,
Madhumeh Amrit: Azadirecta indica Phaseolus mungo 7.5, Cyamompsis
tetragonoloba 7.5 (leaves) 10, Aegle marmelos (leaves) Hordeum
vulgare 5.0, Fagopyrum esculantum 7.5 10 Gymnema sylvestra 10,
Syzygium Gymnema sylvestre 4.5, Momordica charantia 2.25, cumini
(seeds) 10, Ficus glomerata Syzgium cumini 18.0, Pterocarpus
marsupium 0.9, (fruits) 10, Sphaeranthus indicus 10, Trigonella
foenum-graecum 3.6, Cinnamomum tamala Leucas cephalotus 10,
Trigonella 2.25, Withania somnifera 4.5, Coccinia indica 4.5
foenum-graecum 5.0, Symplocos Boerhaavia difussa 4.5, Piper longum
1.0 and racemosus 2.0, Piper cubeb 2.0, Curcuma longa 4.0%.
Nyctanthes arbortristis (flowers) 1.0, Example 8: Glycine max 15.0,
Cicer arietinum 5.0, Withania somnifera 3.0, Mucuna prurita
Phaseolus mungo 10.0, Cyamompsis tetragonoloba 3.0, Shilajit 1.0,
Phyllanthus emblica 10.0, Hordeum vulgare 2.5, Amaranthus 2.0,
Terminalia chebula 1.0, Terminalia hypochondriacus 2.5, Fagopyrum
esculantum 5.0, belerica 1.0, Aegle marmelos 1.0, Gymnema sylvestre
2.475, Momordica charantia 19.8, Memordica charantia (seeds) 3.0,
Syzgium cumini 4.95, Pterocarpus marsupium 2.475, Zingiber
officinale 5.0%. Trigonella foenum-graecum 0.99, Cinnamomum tamala
3.96, Pueraria tuberosa 4.95, Asparagus racemosus 4.95, Aegle
marmelos 4.95 and Piper longum 0.5%.
[0100] The amount of (% composition) of herbs/medicinal plants
extract, seed powders and additional additives in the end
nutraceutical products (Nutra-diab). TABLE-US-00002 Examples 1 2 3
4 5 6 7 8 Plants extract % 10 20 25 30 35 40 45 49.5 Seed 89.5 75
70 65 60 55 50 50 powders % Additives % 0.5 5 5 5 5 5 5 0.5
[0101] TABLE-US-00003 TABLE 2 The amount of (% composition) of seed
powders (legumes , cereals & pseudocereals) in the base
products. (Nutra-Diab) Essential Example Nos. % Legumes 1 2 3 4 5 6
7 8 Range Glycine max 5 15 15 20 20 10 25 30 5-30% Cicer arietinum
10 10 15 15 10 40 20 10 10-40% Phaseolus 5 5 10 10 5 3 15 20 3-20%
mungo Cyamopsis 5 10 5 5 5 2 15 20 2-20% tetragonoloba Optional
Legumes Phaseolus 0 0 0 5 10 15 0 0 0-15% radiatus Mucuna 5 5 5 0
10 0 0 0 0-10% pruriens Total Legumes* 30 45 50 55 60 70 75 80
30-80% Cereal (Essential) Hordeum 40 35 30 25 15 20 10 5 5-40%
vulgare Total cereals** 40 35 30 25 15 20 10 5 5-40% Pseudo Cereals
(Optional) A. hypochon- 10 10 15 15 20 10 0 5 0-20% driacus
Fagopyrum 20 10 5 5 5 0 15 10 0-20% esculantum Total pseudo 30 20
20 20 25 10 15 15 10-30% Cereals*** SUMMARY of the % Composition of
seed powders in base product (Table 1) Example Nos Ingredients% 1 2
3 4 5 6 7 8 % Range * Total Legumes 30 45 50 55 60 70 75 80 30-80%
** Total Cereals 40 35 30 25 15 20 10 5 5-40% *** Total 30 20 20 20
25 10 15 15 10-30% Pseudocereals
[0102] TABLE-US-00004 TABLE 3 The amount of (% composition) of
herbs/medicinal plants in the total mixture used for extraction/or
as powder. Herbs/medi- % cinal plants 1 2 3 4 5 6 7 8 Range
Essential Gymnema 2 40 2 10 5 8 10 5 2-40% sylvestre Momordica 5 5
8 2 5 10 5 40 2-40% charantia Syzgium cumini 8 2 10 8 2 5 40 10
2-40% Pterocarpus 5 10 15 15 8 40 2 5 2-40% marsupium Trigonella 10
8 15 20 40 5 8 2 2-40% foenum- graecum Cinnamomum 40 5 20 15 10 2 5
8 2-40% tamala Optional Herbs Withania 2 3 5 20 0 1 10 0 0-20%
somnifera Coccinia indica 5 0 20 2 3 2 10 0 0-20% Pueraria 20 0 3 5
0 2 0 10 0-20% tuberosa Asparagus 0 20 2 3 5 0 0 10 0-20% recemosus
Boerhaavia 3 2 0 0 20 5 10 0 0-20% diffusa Aegle marmelos 0 5 0 0 2
20 0 10 0-20% Additional Herbs: Piper longum, Curcuma longa,
Chiorophytum tuberosum and Elettaria cardamomu, were used in the
range of up to 4.0% in the end product(s).
[0103] TABLE-US-00005 TABLE 4 Trial feed back remarks from
volunteers of the nutraceutical product(s) 1. Product Volunteered
to take: Herbal health protective and promotive Nutraceutical for
Diabetics 2. Age group: 30-70 years (both men & women) 3.
Number of Volunteers: 10 in each case (8 men & 2 women) 4.
Profession/Family background: Service class, business, retired
& house wife etc 5. Taste & Flavor: Acceptable 6. Feeling
after Consuming the Product: After one week, two weeks & one
month Product One Week Two Weeks One Month Conclusion 1 NS NS NS NS
(10)* 2 NS NS NS NS (10) 3 NS NS Satisfactory NS (10) 4
Satisfactory Satisfactory Good Satisfactory (9) 5 Satisfactory Good
Good Good (7) 6 Good Very Good Very Good Very Good (6) 7 Good Very
Good Very Good Very Good (7) 8 Very Good Very Good Very Good Very
Good (8) 9 Very Good Excellent Excellent Excellent (8) 10** Very
Good Excellent Excellent Excellent (8) 11** Excellent Excellent
Excellent Excellent (8) NS = not significant effect, can not say;
*Number of persons who remarked out often; **The products generated
as final products; The word satisfactory, good, very good arid
excellent stands for the efficacy of the product(s) as reported by
volunteers after consuming the product(s), e.g. no side effects, no
any kind of digestive problem, improvement in vigour, energetic,
general health, and diabetes related health problems. The
concluding remarks of the volunteers include the effect of
nutraceutical product to control Blood/Urine Sugar Level, to
ameliorate diabetes related health problems like fatigue, weakness,
drowsiness, numbing effect, frequent urination, unusual thirst
& hunger, weight loss, blurred vision, frequent skin infections
and slow healing of wounds or sores. Products 1-11 = Base (Roasted
seed powders mixture) + extract of single herb/medicinal plant or
different combinations. Product 1 = Base + Gymnema sylvestre;
Product 2 = Base + Gymnema sylvestre + Momordica charantia; Product
3 = Base + Gymnema sylvestre + Momordica charantia + Syzgium
cumini; Product 4 = Base + Gymnema sylvestre + Momordica charantia
+ Syzgium cumini + Pterocarpus marsupium; Product 5 = Base +
Gymnema sylvestre + # Momordica charantia + Syzgium cumin graecum;
Product 6 = Base + Gymnema sylvestre + Momordica charantia +
Syzgium cumini + Pterocarpus marsupium + Trigonella foenum-graecutn
+ Cinnamomum tamala; Product 7 = Base + Gymnema sylvestre +
Momordica charantia + Syzgium cumini + Pterocarpus marsupium +
Trigonellafoenum-graecum + # Cinnamomum tamala + Withania somnfera;
Product 8 = Base + Gymnema sylvestre + Momordica charantia +
Syzgium cumini + Pterocarpus marsupium + Trigonellafoenum-graecum +
Cinnamomum tamala + Withania somnfera + Pueraria tuberosa; Product
9 = Base + Gymnema sylvestre + Momordica charantia + Syzgium cumini
+ Pterocarpus marsupium # + Trigonellafoenum-graecum + Cinnamomum
tamala + Withania somnifera + Pueraria tuberosa + Asparagus
racemosus; Product 10 = Base + Gymnema sylvestre + Momordica
charantia + Syzgium cumini + Pterocarpus marsupium + Trigonella
foenum-graecum + Cinnamomum tamala + Withania somnfera + Pueraria
tuberosa + Asparagus racemosus # + Boerhaavia diffusa; Product 11 =
Base + Gymnema sylvestre + Mornordica charantia + Syzgium cumini +
Pterocarpus marsupium + Trigonellafoenum-graecum + Cinnamomum
tamala + Withania somnifera + Pueraria tuberosa + Asparagus
racemosus + Boerhaavia diffusa + Aegle marmelos . Suggestions:
Improvement in taste, solubility/ suspension
[0104] TABLE-US-00006 TABLE 5 Trial Feed Back from Volunteers after
consuming the Herbal health protective and promotive
Nutraceutical(s) for Diebetics for 3 months. Sl. Cat- Age Total
Number No. egory Group Male Female of Volunteers Remarks 1. IDDM
4-10 5 5 10 (10*) NS** 2. IDDM 20-50 2 8 10 (5*) Satisfactory 3.
IDDM 50-75 5 5 10 (7*) Good 4. NIDDM 30-40 20 10 30 (24*) Excellent
5. NIDDM 40-50 20 10 30 (21*) Excellent 6. NIDDM 50-85 20 10 30
(21*) Excellent Age Group in years, *Number of persons remark, NS =
Not satisfactory, **did not continue due to its taste Doses: 5 to
10 g (depending on age & symptoms) of the nutraceutical
(Nutra-Diab) was taken twice a day before breakfast/lunch and
dinner, as food supplement beside the normal/usual
drug/medicine/insulin doses etc. being used by the
patient/person.
* * * * *