U.S. patent application number 11/204755 was filed with the patent office on 2006-04-20 for packaging cells comprising codon-optimized gagpol sequences and lacking lentiviral accessory proteins. Invention is credited to John T. Gray, Jeng-Shin Lee, Richard C. Mulligan.
Application Number | 20060084093 11/204755 |
Document ID | / |
Family ID | 35115250 |
Filed Date | 2006-04-20 |
United States Patent Application | 20060084093 |
Kind Code | A1 |
Lee; Jeng-Shin ; et al. | April 20, 2006 |
Novel packaging cell lines useful for generating viral accessory protein independent HIV-derived retroviral vector particles, methods of constructing such packaging cell lines and methods of using the viral accessory protein independent HIV-derived retroviral vector particles are disclosed.
Inventors: | Lee; Jeng-Shin; (Lincoln, MA) ; Gray; John T.; (Memphis, TN) ; Mulligan; Richard C.; (Cambridge, MA) |
Correspondence Address: |
HAMILTON, BROOK, SMITH & REYNOLDS, P.C. 530 VIRGINIA ROAD P.O. BOX 9133 CONCORD MA 01742-9133 US |
Family ID: | 35115250 |
Appl. No.: | 11/204755 |
Filed: | August 16, 2005 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
09393795 | Sep 10, 1999 | 6958226 | ||
11204755 | Aug 16, 2005 | |||
60100063 | Sep 12, 1998 | |||
60100022 | Sep 11, 1998 | |||
Current U.S. Class: | 435/6.11 ; 435/5 |
Current CPC Class: | C12N 2740/16043 20130101; C12N 15/86 20130101; C12N 7/00 20130101; C12N 2740/16052 20130101 |
Class at Publication: | 435/006 ; 435/005 |
International Class: | C12Q 1/70 20060101 C12Q001/70; C12Q 1/68 20060101 C12Q001/68 |
Sequence CWU 1
1
12 1 396 DNA Homo sapiens 1 atgggtgcga gagcgtcagt attaagcggg
ggagaattag atcgatggga aaaaattcgg 60 ttaaggccag ggggaaagaa
aaaatataaa ttaaaacata tagtatgggc aagcagggag 120 ctagaacgat
tcgcagttaa tcctggcctg ttagaaacat cagaaggctg tagacaaata 180
ctgggacagc tacaaccatc ccttcagaca ggatcagaag aacttagatc attatataat
240 acagtagcaa ccctctattg tgtgcatcaa aggatagaga taaaagacac
caaggaagct 300 ttagacaaga tagaggaaga gcaaaacaaa agtaagaaaa
aagcacagca agcagcagct 360 gacacaggac acagcaatca ggtcagccaa aattac
396 2 1503 DNA Homo Sapiens CDS (1)...(1503) 2 atg ggt gcg aga gcg
tcg gta tta agc ggg gga gaa tta gat aaa tgg 48 Met Gly Ala Arg Ala
Ser Val Leu Ser Gly Gly Glu Leu Asp Lys Trp 1 5 10 15 gaa aaa att
cgg tta agg cca ggg gga aag aaa caa tat aaa cta aaa 96 Glu Lys Ile
Arg Leu Arg Pro Gly Gly Lys Lys Gln Tyr Lys Leu Lys 20 25 30 cat
ata gta tgg gca agc agg gag cta gaa cga ttc gca gtt aat cct 144 His
Ile Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Val Asn Pro 35 40
45 ggc ctt tta gag aca tca gaa ggc tgt aga caa ata ctg gga cag cta
192 Gly Leu Leu Glu Thr Ser Glu Gly Cys Arg Gln Ile Leu Gly Gln Leu
50 55 60 caa cca tcc ctt cag aca gga tca gaa gaa ctt aga tca tta
tat aat 240 Gln Pro Ser Leu Gln Thr Gly Ser Glu Glu Leu Arg Ser Leu
Tyr Asn 65 70 75 80 aca ata gca gtc ctc tat tgt gtg cat caa agg ata
gat gta aaa gac 288 Thr Ile Ala Val Leu Tyr Cys Val His Gln Arg Ile
Asp Val Lys Asp 85 90 95 acc aag gaa gcc tta gat aag ata gag gaa
gag caa aac aaa agt aag 336 Thr Lys Glu Ala Leu Asp Lys Ile Glu Glu
Glu Gln Asn Lys Ser Lys 100 105 110 aaa aag gca cag caa gca gca gct
gac aca gga aac aac agc cag gtc 384 Lys Lys Ala Gln Gln Ala Ala Ala
Asp Thr Gly Asn Asn Ser Gln Val 115 120 125 agc caa aat tac cct ata
gtg cag aac ctc cag ggg caa atg gta cat 432 Ser Gln Asn Tyr Pro Ile
Val Gln Asn Leu Gln Gly Gln Met Val His 130 135 140 cag gcc ata tca
cct aga act tta aat gca tgg gta aaa gta gta gaa 480 Gln Ala Ile Ser
Pro Arg Thr Leu Asn Ala Trp Val Lys Val Val Glu 145 150 155 160 gag
aag gct ttc agc cca gaa gta ata ccc atg ttt tca gca tta tca 528 Glu
Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu Ser 165 170
175 gaa gga gcc acc cca caa gat tta aat acc atg cta aac aca gtg ggg
576 Glu Gly Ala Thr Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly
180 185 190 gga cat caa gca gcc atg caa atg tta aaa gag acc atc aat
gag gaa 624 Gly His Gln Ala Ala Met Gln Met Leu Lys Glu Thr Ile Asn
Glu Glu 195 200 205 gct gca gaa tgg gat aga ttg cat cca gtg cat gca
ggg cct att gca 672 Ala Ala Glu Trp Asp Arg Leu His Pro Val His Ala
Gly Pro Ile Ala 210 215 220 cca ggc cag atg aga gaa cca agg gga agt
gac ata gca gga act act 720 Pro Gly Gln Met Arg Glu Pro Arg Gly Ser
Asp Ile Ala Gly Thr Thr 225 230 235 240 agt acc ctt cag gaa caa ata
gga tgg atg aca cat aat cca cct atc 768 Ser Thr Leu Gln Glu Gln Ile
Gly Trp Met Thr His Asn Pro Pro Ile 245 250 255 cca gta gga gaa atc
tat aaa aga tgg ata atc ctg gga tta aat aaa 816 Pro Val Gly Glu Ile
Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys 260 265 270 ata gta aga
atg tat agc cct acc agc att ctg gac ata aga caa gga 864 Ile Val Arg
Met Tyr Ser Pro Thr Ser Ile Leu Asp Ile Arg Gln Gly 275 280 285 cca
aag gaa ccc ttt aga gac tat gta gac cga ttc tat aaa act cta 912 Pro
Lys Glu Pro Phe Arg Asp Tyr Val Asp Arg Phe Tyr Lys Thr Leu 290 295
300 aga gcc gag caa gct tca caa gag gta aaa aat tgg atg aca gaa acc
960 Arg Ala Glu Gln Ala Ser Gln Glu Val Lys Asn Trp Met Thr Glu Thr
305 310 315 320 ttg ttg gtc caa aat gcg aac cca gat tgt aag act att
tta aaa gca 1008 Leu Leu Val Gln Asn Ala Asn Pro Asp Cys Lys Thr
Ile Leu Lys Ala 325 330 335 ttg gga cca gga gcg aca cta gaa gaa atg
atg aca gca tgt cag gga 1056 Leu Gly Pro Gly Ala Thr Leu Glu Glu
Met Met Thr Ala Cys Gln Gly 340 345 350 gtg ggg gga ccc ggc cat aaa
gca aga gtt ttg gct gaa gca atg agc 1104 Val Gly Gly Pro Gly His
Lys Ala Arg Val Leu Ala Glu Ala Met Ser 355 360 365 caa gta aca aat
cca gct acc ata atg ata cag aaa ggc aat ttt agg 1152 Gln Val Thr
Asn Pro Ala Thr Ile Met Ile Gln Lys Gly Asn Phe Arg 370 375 380 aac
caa aga aag act gtt aag tgt ttc aat tgt ggc aaa gaa ggg cac 1200
Asn Gln Arg Lys Thr Val Lys Cys Phe Asn Cys Gly Lys Glu Gly His 385
390 395 400 ata gcc aaa aat tgc agg gcc cct agg aaa aag ggc tgt tgg
aaa tgt 1248 Ile Ala Lys Asn Cys Arg Ala Pro Arg Lys Lys Gly Cys
Trp Lys Cys 405 410 415 gga aag gaa gga cac caa atg aaa gat tgt act
gag aga cag gct aat 1296 Gly Lys Glu Gly His Gln Met Lys Asp Cys
Thr Glu Arg Gln Ala Asn 420 425 430 ttt tta ggg aag atc tgg cct tcc
cac aag gga agg cca ggg aat ttt 1344 Phe Leu Gly Lys Ile Trp Pro
Ser His Lys Gly Arg Pro Gly Asn Phe 435 440 445 ctt cag agc aga cca
gag cca aca gcc cca cca gaa gag agc ttc agg 1392 Leu Gln Ser Arg
Pro Glu Pro Thr Ala Pro Pro Glu Glu Ser Phe Arg 450 455 460 ttt ggg
gaa gag aca aca act ccc tct cag aag cag gag ccg ata gac 1440 Phe
Gly Glu Glu Thr Thr Thr Pro Ser Gln Lys Gln Glu Pro Ile Asp 465 470
475 480 aag gaa ctg tat cct tta gct tcc ctc aga tca ctc ttt ggc agc
gac 1488 Lys Glu Leu Tyr Pro Leu Ala Ser Leu Arg Ser Leu Phe Gly
Ser Asp 485 490 495 ccc tcg tca caa taa 1503 Pro Ser Ser Gln * 500
3 500 PRT Homo Sapiens 3 Met Gly Ala Arg Ala Ser Val Leu Ser Gly
Gly Glu Leu Asp Lys Trp 1 5 10 15 Glu Lys Ile Arg Leu Arg Pro Gly
Gly Lys Lys Gln Tyr Lys Leu Lys 20 25 30 His Ile Val Trp Ala Ser
Arg Glu Leu Glu Arg Phe Ala Val Asn Pro 35 40 45 Gly Leu Leu Glu
Thr Ser Glu Gly Cys Arg Gln Ile Leu Gly Gln Leu 50 55 60 Gln Pro
Ser Leu Gln Thr Gly Ser Glu Glu Leu Arg Ser Leu Tyr Asn 65 70 75 80
Thr Ile Ala Val Leu Tyr Cys Val His Gln Arg Ile Asp Val Lys Asp 85
90 95 Thr Lys Glu Ala Leu Asp Lys Ile Glu Glu Glu Gln Asn Lys Ser
Lys 100 105 110 Lys Lys Ala Gln Gln Ala Ala Ala Asp Thr Gly Asn Asn
Ser Gln Val 115 120 125 Ser Gln Asn Tyr Pro Ile Val Gln Asn Leu Gln
Gly Gln Met Val His 130 135 140 Gln Ala Ile Ser Pro Arg Thr Leu Asn
Ala Trp Val Lys Val Val Glu 145 150 155 160 Glu Lys Ala Phe Ser Pro
Glu Val Ile Pro Met Phe Ser Ala Leu Ser 165 170 175 Glu Gly Ala Thr
Pro Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly 180 185 190 Gly His
Gln Ala Ala Met Gln Met Leu Lys Glu Thr Ile Asn Glu Glu 195 200 205
Ala Ala Glu Trp Asp Arg Leu His Pro Val His Ala Gly Pro Ile Ala 210
215 220 Pro Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr
Thr 225 230 235 240 Ser Thr Leu Gln Glu Gln Ile Gly Trp Met Thr His
Asn Pro Pro Ile 245 250 255 Pro Val Gly Glu Ile Tyr Lys Arg Trp Ile
Ile Leu Gly Leu Asn Lys 260 265 270 Ile Val Arg Met Tyr Ser Pro Thr
Ser Ile Leu Asp Ile Arg Gln Gly 275 280 285 Pro Lys Glu Pro Phe Arg
Asp Tyr Val Asp Arg Phe Tyr Lys Thr Leu 290 295 300 Arg Ala Glu Gln
Ala Ser Gln Glu Val Lys Asn Trp Met Thr Glu Thr 305 310 315 320 Leu
Leu Val Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Lys Ala 325 330
335 Leu Gly Pro Gly Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly
340 345 350 Val Gly Gly Pro Gly His Lys Ala Arg Val Leu Ala Glu Ala
Met Ser 355 360 365 Gln Val Thr Asn Pro Ala Thr Ile Met Ile Gln Lys
Gly Asn Phe Arg 370 375 380 Asn Gln Arg Lys Thr Val Lys Cys Phe Asn
Cys Gly Lys Glu Gly His 385 390 395 400 Ile Ala Lys Asn Cys Arg Ala
Pro Arg Lys Lys Gly Cys Trp Lys Cys 405 410 415 Gly Lys Glu Gly His
Gln Met Lys Asp Cys Thr Glu Arg Gln Ala Asn 420 425 430 Phe Leu Gly
Lys Ile Trp Pro Ser His Lys Gly Arg Pro Gly Asn Phe 435 440 445 Leu
Gln Ser Arg Pro Glu Pro Thr Ala Pro Pro Glu Glu Ser Phe Arg 450 455
460 Phe Gly Glu Glu Thr Thr Thr Pro Ser Gln Lys Gln Glu Pro Ile Asp
465 470 475 480 Lys Glu Leu Tyr Pro Leu Ala Ser Leu Arg Ser Leu Phe
Gly Ser Asp 485 490 495 Pro Ser Ser Gln 500 4 1503 DNA Artificial
Sequence Codon optimized form of HIV gag coding region 4 atg ggc
gcc cgc gcc tcc gtg ctg tcc ggc ggc gag ctg gac aag tgg 48 Met Gly
Ala Arg Ala Ser Val Leu Ser Gly Gly Glu Leu Asp Lys Trp 1 5 10 15
gag aag atc cgc ctg cgc ccc ggc ggc aag aag cag tac aag ctg aag 96
Glu Lys Ile Arg Leu Arg Pro Gly Gly Lys Lys Gln Tyr Lys Leu Lys 20
25 30 cac atc gtg tgg gcc tcc cgc gag ctg gag cgc ttc gcc gtg aac
ccc 144 His Ile Val Trp Ala Ser Arg Glu Leu Glu Arg Phe Ala Val Asn
Pro 35 40 45 ggc ctg ctg gag acc tcc gag ggc tgc cgc cag atc ctg
ggc cag ctg 192 Gly Leu Leu Glu Thr Ser Glu Gly Cys Arg Gln Ile Leu
Gly Gln Leu 50 55 60 cag ccc tcc ctg caa acc ggc tcc gag gag ctg
cgc tcc ctg tac aac 240 Gln Pro Ser Leu Gln Thr Gly Ser Glu Glu Leu
Arg Ser Leu Tyr Asn 65 70 75 80 acc atc gcc gtg ctg tac tgc gtg cac
cag cgc atc gac gtg aag gac 288 Thr Ile Ala Val Leu Tyr Cys Val His
Gln Arg Ile Asp Val Lys Asp 85 90 95 acc aag gag gcc ctg gac aag
atc gag gag gag cag aac aag tcc aag 336 Thr Lys Glu Ala Leu Asp Lys
Ile Glu Glu Glu Gln Asn Lys Ser Lys 100 105 110 aag aag gcc cag cag
gcc gcc gcc gac acc ggc aac aac tcc cag gtg 384 Lys Lys Ala Gln Gln
Ala Ala Ala Asp Thr Gly Asn Asn Ser Gln Val 115 120 125 tcc cag aac
tac ccc atc gtg cag aac ctg cag ggc cag atg gtg cac 432 Ser Gln Asn
Tyr Pro Ile Val Gln Asn Leu Gln Gly Gln Met Val His 130 135 140 cag
gcc atc tcc ccc cgc acc ctg aac gcc tgg gtg aag gtg gtg gag 480 Gln
Ala Ile Ser Pro Arg Thr Leu Asn Ala Trp Val Lys Val Val Glu 145 150
155 160 gag aag gcc ttc tcc ccc gaa gtc atc ccc atg ttc tcc gcc ctg
tcc 528 Glu Lys Ala Phe Ser Pro Glu Val Ile Pro Met Phe Ser Ala Leu
Ser 165 170 175 gag ggc gcc acc ccc cag gac ctg aac acc atg ctg aac
acc gtg ggc 576 Glu Gly Ala Thr Pro Gln Asp Leu Asn Thr Met Leu Asn
Thr Val Gly 180 185 190 ggc cac cag gcc gcc atg cag atg ctg aag gag
acc atc aac gag gag 624 Gly His Gln Ala Ala Met Gln Met Leu Lys Glu
Thr Ile Asn Glu Glu 195 200 205 gcc gcc gag tgg gac cgc ctg cac ccc
gtg cac gcc ggc ccc atc gcc 672 Ala Ala Glu Trp Asp Arg Leu His Pro
Val His Ala Gly Pro Ile Ala 210 215 220 ccc ggc cag atg cgc gag ccc
cgc ggc tcc gac atc gcc ggc acc acc 720 Pro Gly Gln Met Arg Glu Pro
Arg Gly Ser Asp Ile Ala Gly Thr Thr 225 230 235 240 tcc acc ctg caa
gag cag atc ggc tgg atg acc cac aac ccc ccc atc 768 Ser Thr Leu Gln
Glu Gln Ile Gly Trp Met Thr His Asn Pro Pro Ile 245 250 255 ccc gtg
ggc gag atc tac aag cgc tgg atc atc ctg ggc ctg aac aag 816 Pro Val
Gly Glu Ile Tyr Lys Arg Trp Ile Ile Leu Gly Leu Asn Lys 260 265 270
atc gtg cgc atg tac tcc ccc acc tcc atc ctg gac atc cgc cag ggc 864
Ile Val Arg Met Tyr Ser Pro Thr Ser Ile Leu Asp Ile Arg Gln Gly 275
280 285 ccc aag gag ccc ttc cgc gac tac gtg gac cgc ttc tac aag acc
ctg 912 Pro Lys Glu Pro Phe Arg Asp Tyr Val Asp Arg Phe Tyr Lys Thr
Leu 290 295 300 cgc gcc gag cag gcc tcc cag gag gta aag aac tgg atg
acc gag acc 960 Arg Ala Glu Gln Ala Ser Gln Glu Val Lys Asn Trp Met
Thr Glu Thr 305 310 315 320 ctg ctg gtg cag aac gcc aac ccc gac tgc
aag acc atc ctg aag gcc 1008 Leu Leu Val Gln Asn Ala Asn Pro Asp
Cys Lys Thr Ile Leu Lys Ala 325 330 335 ctg ggc ccc ggc gcc acc ctg
gag gag atg atg acc gcc tgc cag ggc 1056 Leu Gly Pro Gly Ala Thr
Leu Glu Glu Met Met Thr Ala Cys Gln Gly 340 345 350 gtg ggc ggc ccc
ggc cac aag gcc cgc gtg ctg gcc gag gcc atg tcc 1104 Val Gly Gly
Pro Gly His Lys Ala Arg Val Leu Ala Glu Ala Met Ser 355 360 365 caa
gtc acc aac ccc gcc acc atc atg atc cag aag ggc aac ttc cgc 1152
Gln Val Thr Asn Pro Ala Thr Ile Met Ile Gln Lys Gly Asn Phe Arg 370
375 380 aac cag cgc aag acc gtg aag tgc ttc aac tgc ggc aag gag ggc
cac 1200 Asn Gln Arg Lys Thr Val Lys Cys Phe Asn Cys Gly Lys Glu
Gly His 385 390 395 400 atc gcc aag aac tgc cgc gcc ccc cgc aag aag
ggc tgc tgg aag tgc 1248 Ile Ala Lys Asn Cys Arg Ala Pro Arg Lys
Lys Gly Cys Trp Lys Cys 405 410 415 ggc aag gag ggc cac cag atg aaa
gat tgt act gag aga cag gct aat 1296 Gly Lys Glu Gly His Gln Met
Lys Asp Cys Thr Glu Arg Gln Ala Asn 420 425 430 ttt tta ggg aag atc
tgg cct tcc cac aag gga agg cca ggg aat ttt 1344 Phe Leu Gly Lys
Ile Trp Pro Ser His Lys Gly Arg Pro Gly Asn Phe 435 440 445 ctt cag
agc aga cca gag cca aca gcc cca cca gaa gag agc ttc agg 1392 Leu
Gln Ser Arg Pro Glu Pro Thr Ala Pro Pro Glu Glu Ser Phe Arg 450 455
460 ttt ggg gaa gag aca aca act ccc tct cag aag cag gag ccg ata gac
1440 Phe Gly Glu Glu Thr Thr Thr Pro Ser Gln Lys Gln Glu Pro Ile
Asp 465 470 475 480 aag gaa ctg tat cct tta gct tcc ctc aga tca ctc
ttt ggc agc gac 1488 Lys Glu Leu Tyr Pro Leu Ala Ser Leu Arg Ser
Leu Phe Gly Ser Asp 485 490 495 ccc tcg tca caa taa 1503 Pro Ser
Ser Gln * 500 5 500 PRT Artificial Sequence Codon optimized form of
HIV gag coding region 5 Met Gly Ala Arg Ala Ser Val Leu Ser Gly Gly
Glu Leu Asp Lys Trp 1 5 10 15 Glu Lys Ile Arg Leu Arg Pro Gly Gly
Lys Lys Gln Tyr Lys Leu Lys 20 25 30 His Ile Val Trp Ala Ser Arg
Glu Leu Glu Arg Phe Ala Val Asn Pro 35 40 45 Gly Leu Leu Glu Thr
Ser Glu Gly Cys Arg Gln Ile Leu Gly Gln Leu 50 55 60 Gln Pro Ser
Leu Gln Thr Gly Ser Glu Glu Leu Arg Ser Leu Tyr Asn 65 70 75 80 Thr
Ile Ala Val Leu Tyr Cys Val His Gln Arg Ile Asp Val Lys Asp 85 90
95 Thr Lys Glu Ala Leu Asp Lys Ile Glu Glu Glu Gln Asn Lys Ser Lys
100 105 110 Lys Lys Ala Gln Gln Ala Ala Ala Asp Thr Gly Asn Asn Ser
Gln Val 115 120 125 Ser Gln Asn Tyr Pro Ile Val Gln Asn Leu Gln Gly
Gln Met Val His 130 135 140 Gln Ala Ile Ser Pro Arg Thr Leu Asn Ala
Trp Val Lys Val Val Glu 145 150 155 160 Glu Lys Ala Phe Ser Pro Glu
Val Ile Pro Met Phe Ser Ala Leu Ser 165 170 175 Glu Gly Ala Thr Pro
Gln Asp Leu Asn Thr Met Leu Asn Thr Val Gly 180 185 190 Gly His Gln
Ala Ala Met Gln Met Leu Lys Glu Thr Ile Asn Glu Glu 195 200 205 Ala
Ala Glu Trp Asp Arg Leu His Pro Val His Ala Gly Pro Ile Ala 210
215 220 Pro Gly Gln Met Arg Glu Pro Arg Gly Ser Asp Ile Ala Gly Thr
Thr 225 230 235 240 Ser Thr Leu Gln Glu Gln Ile Gly Trp Met Thr His
Asn Pro Pro Ile 245 250 255 Pro Val Gly Glu Ile Tyr Lys Arg Trp Ile
Ile Leu Gly Leu Asn Lys 260 265 270 Ile Val Arg Met Tyr Ser Pro Thr
Ser Ile Leu Asp Ile Arg Gln Gly 275 280 285 Pro Lys Glu Pro Phe Arg
Asp Tyr Val Asp Arg Phe Tyr Lys Thr Leu 290 295 300 Arg Ala Glu Gln
Ala Ser Gln Glu Val Lys Asn Trp Met Thr Glu Thr 305 310 315 320 Leu
Leu Val Gln Asn Ala Asn Pro Asp Cys Lys Thr Ile Leu Lys Ala 325 330
335 Leu Gly Pro Gly Ala Thr Leu Glu Glu Met Met Thr Ala Cys Gln Gly
340 345 350 Val Gly Gly Pro Gly His Lys Ala Arg Val Leu Ala Glu Ala
Met Ser 355 360 365 Gln Val Thr Asn Pro Ala Thr Ile Met Ile Gln Lys
Gly Asn Phe Arg 370 375 380 Asn Gln Arg Lys Thr Val Lys Cys Phe Asn
Cys Gly Lys Glu Gly His 385 390 395 400 Ile Ala Lys Asn Cys Arg Ala
Pro Arg Lys Lys Gly Cys Trp Lys Cys 405 410 415 Gly Lys Glu Gly His
Gln Met Lys Asp Cys Thr Glu Arg Gln Ala Asn 420 425 430 Phe Leu Gly
Lys Ile Trp Pro Ser His Lys Gly Arg Pro Gly Asn Phe 435 440 445 Leu
Gln Ser Arg Pro Glu Pro Thr Ala Pro Pro Glu Glu Ser Phe Arg 450 455
460 Phe Gly Glu Glu Thr Thr Thr Pro Ser Gln Lys Gln Glu Pro Ile Asp
465 470 475 480 Lys Glu Leu Tyr Pro Leu Ala Ser Leu Arg Ser Leu Phe
Gly Ser Asp 485 490 495 Pro Ser Ser Gln 500 6 3012 DNA Homo sapiens
CDS (1)...(3012) 6 ttt ttt agg gaa gat ctg gcc ttc cca caa ggg aag
gcc agg gaa ttt 48 Phe Phe Arg Glu Asp Leu Ala Phe Pro Gln Gly Lys
Ala Arg Glu Phe 1 5 10 15 tct tca gag cag acc aga gcc aac agc ccc
acc aga aga gag ctt cag 96 Ser Ser Glu Gln Thr Arg Ala Asn Ser Pro
Thr Arg Arg Glu Leu Gln 20 25 30 gtt tgg gga aga gac aac aac tcc
ctc tca gaa gca gga gcc gat aga 144 Val Trp Gly Arg Asp Asn Asn Ser
Leu Ser Glu Ala Gly Ala Asp Arg 35 40 45 caa gga act gta tcc ttt
agc ttc cct cag atc act ctt tgg cag cga 192 Gln Gly Thr Val Ser Phe
Ser Phe Pro Gln Ile Thr Leu Trp Gln Arg 50 55 60 ccc ctc gtc aca
ata aag ata ggg ggg caa tta aag gaa gct cta tta 240 Pro Leu Val Thr
Ile Lys Ile Gly Gly Gln Leu Lys Glu Ala Leu Leu 65 70 75 80 gat aca
gga gca gat gat aca gta tta gaa gaa atg aat ttg cca gga 288 Asp Thr
Gly Ala Asp Asp Thr Val Leu Glu Glu Met Asn Leu Pro Gly 85 90 95
aga tgg aaa cca aaa atg ata ggg gga att gga ggt ttt atc aaa gta 336
Arg Trp Lys Pro Lys Met Ile Gly Gly Ile Gly Gly Phe Ile Lys Val 100
105 110 gga cag tat gat cag ata ctc ata gaa atc tgc gga cat aaa gct
ata 384 Gly Gln Tyr Asp Gln Ile Leu Ile Glu Ile Cys Gly His Lys Ala
Ile 115 120 125 ggt aca gta tta gta gga cct aca cct gtc aac ata att
gga aga aat 432 Gly Thr Val Leu Val Gly Pro Thr Pro Val Asn Ile Ile
Gly Arg Asn 130 135 140 ctg ttg act cag att ggc tgc act tta aat ttt
ccc att agt cct att 480 Leu Leu Thr Gln Ile Gly Cys Thr Leu Asn Phe
Pro Ile Ser Pro Ile 145 150 155 160 gag act gta cca gta aaa tta aag
cca gga atg gat ggc cca aaa gtt 528 Glu Thr Val Pro Val Lys Leu Lys
Pro Gly Met Asp Gly Pro Lys Val 165 170 175 aaa caa tgg cca ttg aca
gaa gaa aaa ata aaa gca tta gta gaa att 576 Lys Gln Trp Pro Leu Thr
Glu Glu Lys Ile Lys Ala Leu Val Glu Ile 180 185 190 tgt aca gaa atg
gaa aag gaa gga aaa att tca aaa att ggg cct gaa 624 Cys Thr Glu Met
Glu Lys Glu Gly Lys Ile Ser Lys Ile Gly Pro Glu 195 200 205 aat cca
tac aat act cca gta ttt gcc ata aag aaa aaa gac agt act 672 Asn Pro
Tyr Asn Thr Pro Val Phe Ala Ile Lys Lys Lys Asp Ser Thr 210 215 220
aaa tgg aga aaa tta gta gat ttc aga gaa ctt aat aag aga act caa 720
Lys Trp Arg Lys Leu Val Asp Phe Arg Glu Leu Asn Lys Arg Thr Gln 225
230 235 240 gat ttc tgg gaa gtt caa tta gga ata cca cat cct gca ggg
tta aaa 768 Asp Phe Trp Glu Val Gln Leu Gly Ile Pro His Pro Ala Gly
Leu Lys 245 250 255 cag aaa aaa tca gta aca gta ctg gat gtg ggc gat
gca tat ttt tca 816 Gln Lys Lys Ser Val Thr Val Leu Asp Val Gly Asp
Ala Tyr Phe Ser 260 265 270 gtt ccc tta gat aaa gac ttc agg aag tat
act gca ttt acc ata cct 864 Val Pro Leu Asp Lys Asp Phe Arg Lys Tyr
Thr Ala Phe Thr Ile Pro 275 280 285 agt ata aac aat gag aca cca ggg
att aga tat cag tac aat gtg ctt 912 Ser Ile Asn Asn Glu Thr Pro Gly
Ile Arg Tyr Gln Tyr Asn Val Leu 290 295 300 cca cag gga tgg aaa gga
tca cca gca ata ttc cag tgt agc atg aca 960 Pro Gln Gly Trp Lys Gly
Ser Pro Ala Ile Phe Gln Cys Ser Met Thr 305 310 315 320 aaa atc tta
gag cct ttt aga aaa caa aat cca gac ata gtc atc tat 1008 Lys Ile
Leu Glu Pro Phe Arg Lys Gln Asn Pro Asp Ile Val Ile Tyr 325 330 335
caa tac atg gat gat ttg tat gta gga tct gac tta gaa ata ggg cag
1056 Gln Tyr Met Asp Asp Leu Tyr Val Gly Ser Asp Leu Glu Ile Gly
Gln 340 345 350 cat aga aca aaa ata gag gaa ctg aga caa cat ctg ttg
agg tgg gga 1104 His Arg Thr Lys Ile Glu Glu Leu Arg Gln His Leu
Leu Arg Trp Gly 355 360 365 ttt acc aca cca gac aaa aaa cat cag aaa
gaa cct cca ttc ctt tgg 1152 Phe Thr Thr Pro Asp Lys Lys His Gln
Lys Glu Pro Pro Phe Leu Trp 370 375 380 atg ggt tat gaa ctc cat cct
gat aaa tgg aca gta cag cct ata gtg 1200 Met Gly Tyr Glu Leu His
Pro Asp Lys Trp Thr Val Gln Pro Ile Val 385 390 395 400 ctg cca gaa
aag gac agc tgg act gtc aat gac ata cag aaa tta gtg 1248 Leu Pro
Glu Lys Asp Ser Trp Thr Val Asn Asp Ile Gln Lys Leu Val 405 410 415
gga aaa ttg aat tgg gca agt cag att tat gca ggg att aaa gta agg
1296 Gly Lys Leu Asn Trp Ala Ser Gln Ile Tyr Ala Gly Ile Lys Val
Arg 420 425 430 caa tta tgt aaa ctt ctt agg gga acc aaa gca cta aca
gaa gta gta 1344 Gln Leu Cys Lys Leu Leu Arg Gly Thr Lys Ala Leu
Thr Glu Val Val 435 440 445 cca cta aca gaa gaa gca gag cta gaa ctg
gca gaa aac agg gag att 1392 Pro Leu Thr Glu Glu Ala Glu Leu Glu
Leu Ala Glu Asn Arg Glu Ile 450 455 460 cta aaa gaa ccg gta cat gga
gtg tat tat gac cca tca aaa gac tta 1440 Leu Lys Glu Pro Val His
Gly Val Tyr Tyr Asp Pro Ser Lys Asp Leu 465 470 475 480 ata gca gaa
ata cag aag cag ggg caa ggc caa tgg aca tat caa att 1488 Ile Ala
Glu Ile Gln Lys Gln Gly Gln Gly Gln Trp Thr Tyr Gln Ile 485 490 495
tat caa gag cca ttt aaa aat ctg aaa aca gga aaa tat gca aga atg
1536 Tyr Gln Glu Pro Phe Lys Asn Leu Lys Thr Gly Lys Tyr Ala Arg
Met 500 505 510 aag ggt gcc cac act aat gat gtg aaa caa tta aca gag
gca gta caa 1584 Lys Gly Ala His Thr Asn Asp Val Lys Gln Leu Thr
Glu Ala Val Gln 515 520 525 aaa ata gcc aca gaa agc ata gta ata tgg
gga aag act cct aaa ttt 1632 Lys Ile Ala Thr Glu Ser Ile Val Ile
Trp Gly Lys Thr Pro Lys Phe 530 535 540 aaa tta ccc ata caa aag gaa
aca tgg gaa gca tgg tgg aca gag tat 1680 Lys Leu Pro Ile Gln Lys
Glu Thr Trp Glu Ala Trp Trp Thr Glu Tyr 545 550 555 560 tgg caa gcc
acc tgg att cct gag tgg gag ttt gtc aat acc cct ccc 1728 Trp Gln
Ala Thr Trp Ile Pro Glu Trp Glu Phe Val Asn Thr Pro Pro 565 570 575
tta gtg aag tta tgg tac cag tta gag aaa gaa ccc ata ata gga gca
1776 Leu Val Lys Leu Trp Tyr Gln Leu Glu Lys Glu Pro Ile Ile Gly
Ala 580 585 590 gaa act ttc tat gta gat ggg gca gcc aat agg gaa act
aaa tta gga 1824 Glu Thr Phe Tyr Val Asp Gly Ala Ala Asn Arg Glu
Thr Lys Leu Gly 595 600 605 aaa gca gga tat gta act gac aga gga aga
caa aaa gtt gtc ccc cta 1872 Lys Ala Gly Tyr Val Thr Asp Arg Gly
Arg Gln Lys Val Val Pro Leu 610 615 620 acg gac aca aca aat cag aag
act gag tta caa gca att cat cta gct 1920 Thr Asp Thr Thr Asn Gln
Lys Thr Glu Leu Gln Ala Ile His Leu Ala 625 630 635 640 ttg cag gat
tcg gga tta gaa gta aac ata gtg aca gac tca caa tat 1968 Leu Gln
Asp Ser Gly Leu Glu Val Asn Ile Val Thr Asp Ser Gln Tyr 645 650 655
gca ttg gga atc att caa gca caa cca gat aag agt gaa tca gag tta
2016 Ala Leu Gly Ile Ile Gln Ala Gln Pro Asp Lys Ser Glu Ser Glu
Leu 660 665 670 gtc agt caa ata ata gag cag tta ata aaa aag gaa aaa
gtc tac ctg 2064 Val Ser Gln Ile Ile Glu Gln Leu Ile Lys Lys Glu
Lys Val Tyr Leu 675 680 685 gca tgg gta cca gca cac aaa gga att gga
gga aat gaa caa gta gat 2112 Ala Trp Val Pro Ala His Lys Gly Ile
Gly Gly Asn Glu Gln Val Asp 690 695 700 ggg ttg gtc agt gct gga atc
agg aaa gta cta ttt tta gat gga ata 2160 Gly Leu Val Ser Ala Gly
Ile Arg Lys Val Leu Phe Leu Asp Gly Ile 705 710 715 720 gat aag gcc
caa gaa gaa cat gag aaa tat cac agt aat tgg aga gca 2208 Asp Lys
Ala Gln Glu Glu His Glu Lys Tyr His Ser Asn Trp Arg Ala 725 730 735
atg gct agt gat ttt aac cta cca cct gta gta gca aaa gaa ata gta
2256 Met Ala Ser Asp Phe Asn Leu Pro Pro Val Val Ala Lys Glu Ile
Val 740 745 750 gcc agc tgt gat aaa tgt cag cta aaa ggg gaa gcc atg
cat gga caa 2304 Ala Ser Cys Asp Lys Cys Gln Leu Lys Gly Glu Ala
Met His Gly Gln 755 760 765 gta gac tgt agc cca gga ata tgg cag cta
gat tgt aca cat tta gaa 2352 Val Asp Cys Ser Pro Gly Ile Trp Gln
Leu Asp Cys Thr His Leu Glu 770 775 780 gga aaa gtt atc ttg gta gca
gtt cat gta gcc agt gga tat ata gaa 2400 Gly Lys Val Ile Leu Val
Ala Val His Val Ala Ser Gly Tyr Ile Glu 785 790 795 800 gca gaa gta
att cca gca gag aca ggg caa gaa aca gca tac ttc ctc 2448 Ala Glu
Val Ile Pro Ala Glu Thr Gly Gln Glu Thr Ala Tyr Phe Leu 805 810 815
tta aaa tta gca gga aga tgg cca gta aaa aca gta cat aca gac aat
2496 Leu Lys Leu Ala Gly Arg Trp Pro Val Lys Thr Val His Thr Asp
Asn 820 825 830 ggc agc aat ttc acc agt act aca gtt aag gcc gcc tgt
tgg tgg gcg 2544 Gly Ser Asn Phe Thr Ser Thr Thr Val Lys Ala Ala
Cys Trp Trp Ala 835 840 845 ggg atc aag cag gaa ttt ggc att ccc tac
aat ccc caa agt caa gga 2592 Gly Ile Lys Gln Glu Phe Gly Ile Pro
Tyr Asn Pro Gln Ser Gln Gly 850 855 860 gta ata gaa tct atg aat aaa
gaa tta aag aaa att ata gga cag gta 2640 Val Ile Glu Ser Met Asn
Lys Glu Leu Lys Lys Ile Ile Gly Gln Val 865 870 875 880 aga gat cag
gct gaa cat ctt aag aca gca gta caa atg gca gta ttc 2688 Arg Asp
Gln Ala Glu His Leu Lys Thr Ala Val Gln Met Ala Val Phe 885 890 895
atc cac aat ttt aaa aga aaa ggg ggg att ggg ggg tac agt gca ggg
2736 Ile His Asn Phe Lys Arg Lys Gly Gly Ile Gly Gly Tyr Ser Ala
Gly 900 905 910 gaa aga ata gta gac ata ata gca aca gac ata caa act
aaa gaa tta 2784 Glu Arg Ile Val Asp Ile Ile Ala Thr Asp Ile Gln
Thr Lys Glu Leu 915 920 925 caa aaa caa att aca aaa att caa aat ttt
cgg gtt tat tac agg gac 2832 Gln Lys Gln Ile Thr Lys Ile Gln Asn
Phe Arg Val Tyr Tyr Arg Asp 930 935 940 agc aga gat cca gtt tgg aaa
gga cca gca aag ctc ctc tgg aaa ggt 2880 Ser Arg Asp Pro Val Trp
Lys Gly Pro Ala Lys Leu Leu Trp Lys Gly 945 950 955 960 gaa ggg gca
gta gta ata caa gat aat agt gac ata aaa gta gtg cca 2928 Glu Gly
Ala Val Val Ile Gln Asp Asn Ser Asp Ile Lys Val Val Pro 965 970 975
aga aga aaa gca aag atc atc agg gat tat gga aaa cag atg gca ggt
2976 Arg Arg Lys Ala Lys Ile Ile Arg Asp Tyr Gly Lys Gln Met Ala
Gly 980 985 990 gat gat tgt gtg gca agt aga cag gat gag gat taa
3012 Asp Asp Cys Val Ala Ser Arg Gln Asp Glu Asp * 995 1000 7 1003
PRT Homo sapiens 7 Phe Phe Arg Glu Asp Leu Ala Phe Pro Gln Gly Lys
Ala Arg Glu Phe 1 5 10 15 Ser Ser Glu Gln Thr Arg Ala Asn Ser Pro
Thr Arg Arg Glu Leu Gln 20 25 30 Val Trp Gly Arg Asp Asn Asn Ser
Leu Ser Glu Ala Gly Ala Asp Arg 35 40 45 Gln Gly Thr Val Ser Phe
Ser Phe Pro Gln Ile Thr Leu Trp Gln Arg 50 55 60 Pro Leu Val Thr
Ile Lys Ile Gly Gly Gln Leu Lys Glu Ala Leu Leu 65 70 75 80 Asp Thr
Gly Ala Asp Asp Thr Val Leu Glu Glu Met Asn Leu Pro Gly 85 90 95
Arg Trp Lys Pro Lys Met Ile Gly Gly Ile Gly Gly Phe Ile Lys Val 100
105 110 Gly Gln Tyr Asp Gln Ile Leu Ile Glu Ile Cys Gly His Lys Ala
Ile 115 120 125 Gly Thr Val Leu Val Gly Pro Thr Pro Val Asn Ile Ile
Gly Arg Asn 130 135 140 Leu Leu Thr Gln Ile Gly Cys Thr Leu Asn Phe
Pro Ile Ser Pro Ile 145 150 155 160 Glu Thr Val Pro Val Lys Leu Lys
Pro Gly Met Asp Gly Pro Lys Val 165 170 175 Lys Gln Trp Pro Leu Thr
Glu Glu Lys Ile Lys Ala Leu Val Glu Ile 180 185 190 Cys Thr Glu Met
Glu Lys Glu Gly Lys Ile Ser Lys Ile Gly Pro Glu 195 200 205 Asn Pro
Tyr Asn Thr Pro Val Phe Ala Ile Lys Lys Lys Asp Ser Thr 210 215 220
Lys Trp Arg Lys Leu Val Asp Phe Arg Glu Leu Asn Lys Arg Thr Gln 225
230 235 240 Asp Phe Trp Glu Val Gln Leu Gly Ile Pro His Pro Ala Gly
Leu Lys 245 250 255 Gln Lys Lys Ser Val Thr Val Leu Asp Val Gly Asp
Ala Tyr Phe Ser 260 265 270 Val Pro Leu Asp Lys Asp Phe Arg Lys Tyr
Thr Ala Phe Thr Ile Pro 275 280 285 Ser Ile Asn Asn Glu Thr Pro Gly
Ile Arg Tyr Gln Tyr Asn Val Leu 290 295 300 Pro Gln Gly Trp Lys Gly
Ser Pro Ala Ile Phe Gln Cys Ser Met Thr 305 310 315 320 Lys Ile Leu
Glu Pro Phe Arg Lys Gln Asn Pro Asp Ile Val Ile Tyr 325 330 335 Gln
Tyr Met Asp Asp Leu Tyr Val Gly Ser Asp Leu Glu Ile Gly Gln 340 345
350 His Arg Thr Lys Ile Glu Glu Leu Arg Gln His Leu Leu Arg Trp Gly
355 360 365 Phe Thr Thr Pro Asp Lys Lys His Gln Lys Glu Pro Pro Phe
Leu Trp 370 375 380 Met Gly Tyr Glu Leu His Pro Asp Lys Trp Thr Val
Gln Pro Ile Val 385 390 395 400 Leu Pro Glu Lys Asp Ser Trp Thr Val
Asn Asp Ile Gln Lys Leu Val 405 410 415 Gly Lys Leu Asn Trp Ala Ser
Gln Ile Tyr Ala Gly Ile Lys Val Arg 420 425 430 Gln Leu Cys Lys Leu
Leu Arg Gly Thr Lys Ala Leu Thr Glu Val Val 435 440 445 Pro Leu Thr
Glu Glu Ala Glu Leu Glu Leu Ala Glu Asn Arg Glu Ile 450 455 460 Leu
Lys Glu Pro Val His Gly Val Tyr Tyr Asp Pro Ser Lys Asp Leu 465 470
475 480 Ile Ala Glu Ile Gln Lys Gln Gly Gln Gly Gln Trp Thr Tyr Gln
Ile 485 490 495 Tyr Gln Glu Pro Phe Lys Asn Leu Lys Thr Gly Lys Tyr
Ala Arg Met 500 505 510 Lys Gly Ala His Thr Asn Asp Val Lys Gln Leu
Thr Glu Ala Val Gln 515 520 525 Lys Ile Ala Thr Glu Ser Ile Val Ile
Trp Gly Lys Thr Pro Lys Phe 530
535 540 Lys Leu Pro Ile Gln Lys Glu Thr Trp Glu Ala Trp Trp Thr Glu
Tyr 545 550 555 560 Trp Gln Ala Thr Trp Ile Pro Glu Trp Glu Phe Val
Asn Thr Pro Pro 565 570 575 Leu Val Lys Leu Trp Tyr Gln Leu Glu Lys
Glu Pro Ile Ile Gly Ala 580 585 590 Glu Thr Phe Tyr Val Asp Gly Ala
Ala Asn Arg Glu Thr Lys Leu Gly 595 600 605 Lys Ala Gly Tyr Val Thr
Asp Arg Gly Arg Gln Lys Val Val Pro Leu 610 615 620 Thr Asp Thr Thr
Asn Gln Lys Thr Glu Leu Gln Ala Ile His Leu Ala 625 630 635 640 Leu
Gln Asp Ser Gly Leu Glu Val Asn Ile Val Thr Asp Ser Gln Tyr 645 650
655 Ala Leu Gly Ile Ile Gln Ala Gln Pro Asp Lys Ser Glu Ser Glu Leu
660 665 670 Val Ser Gln Ile Ile Glu Gln Leu Ile Lys Lys Glu Lys Val
Tyr Leu 675 680 685 Ala Trp Val Pro Ala His Lys Gly Ile Gly Gly Asn
Glu Gln Val Asp 690 695 700 Gly Leu Val Ser Ala Gly Ile Arg Lys Val
Leu Phe Leu Asp Gly Ile 705 710 715 720 Asp Lys Ala Gln Glu Glu His
Glu Lys Tyr His Ser Asn Trp Arg Ala 725 730 735 Met Ala Ser Asp Phe
Asn Leu Pro Pro Val Val Ala Lys Glu Ile Val 740 745 750 Ala Ser Cys
Asp Lys Cys Gln Leu Lys Gly Glu Ala Met His Gly Gln 755 760 765 Val
Asp Cys Ser Pro Gly Ile Trp Gln Leu Asp Cys Thr His Leu Glu 770 775
780 Gly Lys Val Ile Leu Val Ala Val His Val Ala Ser Gly Tyr Ile Glu
785 790 795 800 Ala Glu Val Ile Pro Ala Glu Thr Gly Gln Glu Thr Ala
Tyr Phe Leu 805 810 815 Leu Lys Leu Ala Gly Arg Trp Pro Val Lys Thr
Val His Thr Asp Asn 820 825 830 Gly Ser Asn Phe Thr Ser Thr Thr Val
Lys Ala Ala Cys Trp Trp Ala 835 840 845 Gly Ile Lys Gln Glu Phe Gly
Ile Pro Tyr Asn Pro Gln Ser Gln Gly 850 855 860 Val Ile Glu Ser Met
Asn Lys Glu Leu Lys Lys Ile Ile Gly Gln Val 865 870 875 880 Arg Asp
Gln Ala Glu His Leu Lys Thr Ala Val Gln Met Ala Val Phe 885 890 895
Ile His Asn Phe Lys Arg Lys Gly Gly Ile Gly Gly Tyr Ser Ala Gly 900
905 910 Glu Arg Ile Val Asp Ile Ile Ala Thr Asp Ile Gln Thr Lys Glu
Leu 915 920 925 Gln Lys Gln Ile Thr Lys Ile Gln Asn Phe Arg Val Tyr
Tyr Arg Asp 930 935 940 Ser Arg Asp Pro Val Trp Lys Gly Pro Ala Lys
Leu Leu Trp Lys Gly 945 950 955 960 Glu Gly Ala Val Val Ile Gln Asp
Asn Ser Asp Ile Lys Val Val Pro 965 970 975 Arg Arg Lys Ala Lys Ile
Ile Arg Asp Tyr Gly Lys Gln Met Ala Gly 980 985 990 Asp Asp Cys Val
Ala Ser Arg Gln Asp Glu Asp 995 1000 8 3012 DNA Homo sapiens CDS
(1)...(3012) 8 ttt ttt agg gaa gat ctg gcc ttc cca caa ggg aag gcc
agg gaa ttt 48 Phe Phe Arg Glu Asp Leu Ala Phe Pro Gln Gly Lys Ala
Arg Glu Phe 1 5 10 15 tct tca gag cag acc aga gcc aac agc ccc acc
aga aga gag ctt cag 96 Ser Ser Glu Gln Thr Arg Ala Asn Ser Pro Thr
Arg Arg Glu Leu Gln 20 25 30 gtt tgg gga aga gac aac aac tcc ctc
tca gaa gca gga gcc gat aga 144 Val Trp Gly Arg Asp Asn Asn Ser Leu
Ser Glu Ala Gly Ala Asp Arg 35 40 45 caa gga act gta tcc ttt agc
ttc cct cag atc act ctt tgg cag cga 192 Gln Gly Thr Val Ser Phe Ser
Phe Pro Gln Ile Thr Leu Trp Gln Arg 50 55 60 ccc ctc gtc aca ata
aag ata ggg ggg caa tta aag gaa gct cta tta 240 Pro Leu Val Thr Ile
Lys Ile Gly Gly Gln Leu Lys Glu Ala Leu Leu 65 70 75 80 gat aca gga
gca gat gat aca gta tta gaa gaa atg aat ttg cca gga 288 Asp Thr Gly
Ala Asp Asp Thr Val Leu Glu Glu Met Asn Leu Pro Gly 85 90 95 aga
tgg aaa cca aaa atg ata ggg gga att gga ggt ttt atc aaa gta 336 Arg
Trp Lys Pro Lys Met Ile Gly Gly Ile Gly Gly Phe Ile Lys Val 100 105
110 aga cag tat gat cag ata ctc ata gaa atc tgc gga cat aaa gct ata
384 Arg Gln Tyr Asp Gln Ile Leu Ile Glu Ile Cys Gly His Lys Ala Ile
115 120 125 ggt aca gta tta gta gga cct aca cct gtc aac ata att gga
aga aat 432 Gly Thr Val Leu Val Gly Pro Thr Pro Val Asn Ile Ile Gly
Arg Asn 130 135 140 ctg ttg act cag att ggc tgc act tta aat ttt ccc
att agt cct att 480 Leu Leu Thr Gln Ile Gly Cys Thr Leu Asn Phe Pro
Ile Ser Pro Ile 145 150 155 160 gag act gta cca gta aaa tta aag cca
gga atg gat ggc cca aaa gtt 528 Glu Thr Val Pro Val Lys Leu Lys Pro
Gly Met Asp Gly Pro Lys Val 165 170 175 aaa caa tgg cca ttg aca gaa
gaa aaa ata aaa gca tta gta gaa att 576 Lys Gln Trp Pro Leu Thr Glu
Glu Lys Ile Lys Ala Leu Val Glu Ile 180 185 190 tgt aca gaa atg gaa
aag gaa gga aaa att tca aaa att ggg cct gaa 624 Cys Thr Glu Met Glu
Lys Glu Gly Lys Ile Ser Lys Ile Gly Pro Glu 195 200 205 aat cca tac
aat act cca gta ttt gcc ata aag aaa aaa gac agt act 672 Asn Pro Tyr
Asn Thr Pro Val Phe Ala Ile Lys Lys Lys Asp Ser Thr 210 215 220 aaa
tgg aga aaa tta gta gat ttc aga gaa ctt aat aag aga act caa 720 Lys
Trp Arg Lys Leu Val Asp Phe Arg Glu Leu Asn Lys Arg Thr Gln 225 230
235 240 gat ttc tgg gaa gtt caa tta gga ata cca cat cct gca ggg tta
aaa 768 Asp Phe Trp Glu Val Gln Leu Gly Ile Pro His Pro Ala Gly Leu
Lys 245 250 255 cag aaa aaa tca gta aca gta ctg gat gtg ggc gat gca
tat ttt tca 816 Gln Lys Lys Ser Val Thr Val Leu Asp Val Gly Asp Ala
Tyr Phe Ser 260 265 270 gtt ccc tta gat aaa gac ttc agg aag tat act
gca ttt acc ata cct 864 Val Pro Leu Asp Lys Asp Phe Arg Lys Tyr Thr
Ala Phe Thr Ile Pro 275 280 285 agt ata aac aat gag aca cca ggg att
aga tat cag tac aat gtg ctt 912 Ser Ile Asn Asn Glu Thr Pro Gly Ile
Arg Tyr Gln Tyr Asn Val Leu 290 295 300 cca cag gga tgg aaa gga tca
cca gca ata ttc cag tgt agc atg aca 960 Pro Gln Gly Trp Lys Gly Ser
Pro Ala Ile Phe Gln Cys Ser Met Thr 305 310 315 320 aaa atc tta gag
cct ttt aga aaa caa aat cca gac ata gtc atc tat 1008 Lys Ile Leu
Glu Pro Phe Arg Lys Gln Asn Pro Asp Ile Val Ile Tyr 325 330 335 caa
tac atg gat gat ttg tat gta gga tct gac tta gaa ata ggg cag 1056
Gln Tyr Met Asp Asp Leu Tyr Val Gly Ser Asp Leu Glu Ile Gly Gln 340
345 350 cat aga aca aaa ata gag gaa ctg aga caa cat ctg ttg agg tgg
gga 1104 His Arg Thr Lys Ile Glu Glu Leu Arg Gln His Leu Leu Arg
Trp Gly 355 360 365 ttt acc aca cca gac aaa aaa cat cag aaa gaa cct
cca ttc ctt tgg 1152 Phe Thr Thr Pro Asp Lys Lys His Gln Lys Glu
Pro Pro Phe Leu Trp 370 375 380 atg ggt tat gaa ctc cat cct gat aaa
tgg aca gta cag cct ata gtg 1200 Met Gly Tyr Glu Leu His Pro Asp
Lys Trp Thr Val Gln Pro Ile Val 385 390 395 400 ctg cca gaa aag gac
agc tgg act gtc aat gac ata cag aaa tta gtg 1248 Leu Pro Glu Lys
Asp Ser Trp Thr Val Asn Asp Ile Gln Lys Leu Val 405 410 415 gga aaa
ttg aat tgg gca agt cag att tat gca ggg att aaa gta agg 1296 Gly
Lys Leu Asn Trp Ala Ser Gln Ile Tyr Ala Gly Ile Lys Val Arg 420 425
430 caa tta tgt aaa ctt ctt agg gga acc aaa gca cta aca gaa gta gta
1344 Gln Leu Cys Lys Leu Leu Arg Gly Thr Lys Ala Leu Thr Glu Val
Val 435 440 445 cca cta aca gaa gaa gca gag cta gaa ctg gca gaa aac
agg gag att 1392 Pro Leu Thr Glu Glu Ala Glu Leu Glu Leu Ala Glu
Asn Arg Glu Ile 450 455 460 cta aaa gaa ccg gta cat gga gtg tat tat
gac cca tca aaa gac tta 1440 Leu Lys Glu Pro Val His Gly Val Tyr
Tyr Asp Pro Ser Lys Asp Leu 465 470 475 480 ata gca gaa ata cag aag
cag ggg caa ggc caa tgg aca tat caa att 1488 Ile Ala Glu Ile Gln
Lys Gln Gly Gln Gly Gln Trp Thr Tyr Gln Ile 485 490 495 tat caa gag
cca ttt aaa aat ctg aaa aca gga aaa tat gca aga atg 1536 Tyr Gln
Glu Pro Phe Lys Asn Leu Lys Thr Gly Lys Tyr Ala Arg Met 500 505 510
aag ggt gcc cac act aat gat gtg aaa caa tta aca gag gca gta caa
1584 Lys Gly Ala His Thr Asn Asp Val Lys Gln Leu Thr Glu Ala Val
Gln 515 520 525 aaa ata gcc aca gaa agc ata gta ata tgg gga aag act
cct aaa ttt 1632 Lys Ile Ala Thr Glu Ser Ile Val Ile Trp Gly Lys
Thr Pro Lys Phe 530 535 540 aaa tta ccc ata caa aag gaa aca tgg gaa
gca tgg tgg aca gag tat 1680 Lys Leu Pro Ile Gln Lys Glu Thr Trp
Glu Ala Trp Trp Thr Glu Tyr 545 550 555 560 tgg caa gcc acc tgg att
cct gag tgg gag ttt gtc aat acc cct ccc 1728 Trp Gln Ala Thr Trp
Ile Pro Glu Trp Glu Phe Val Asn Thr Pro Pro 565 570 575 tta gtg aag
tta tgg tac cag tta gag aaa gaa ccc ata ata gga gca 1776 Leu Val
Lys Leu Trp Tyr Gln Leu Glu Lys Glu Pro Ile Ile Gly Ala 580 585 590
gaa act ttc tat gta gat ggg gca gcc aat agg gaa act aaa tta gga
1824 Glu Thr Phe Tyr Val Asp Gly Ala Ala Asn Arg Glu Thr Lys Leu
Gly 595 600 605 aaa gca gga tat gta act gac aga gga aga caa aaa gtt
gtc ccc cta 1872 Lys Ala Gly Tyr Val Thr Asp Arg Gly Arg Gln Lys
Val Val Pro Leu 610 615 620 acg gac aca aca aat cag aag act gag tta
caa gca att cat cta gct 1920 Thr Asp Thr Thr Asn Gln Lys Thr Glu
Leu Gln Ala Ile His Leu Ala 625 630 635 640 ttg cag gat tcg gga tta
gaa gta aac ata gtg aca gac tca caa tat 1968 Leu Gln Asp Ser Gly
Leu Glu Val Asn Ile Val Thr Asp Ser Gln Tyr 645 650 655 gca ttg gga
atc att caa gca caa cca gat aag agt gaa tca gag tta 2016 Ala Leu
Gly Ile Ile Gln Ala Gln Pro Asp Lys Ser Glu Ser Glu Leu 660 665 670
gtc agt caa ata ata gag cag tta ata aaa aag gaa aaa gtc tac ctg
2064 Val Ser Gln Ile Ile Glu Gln Leu Ile Lys Lys Glu Lys Val Tyr
Leu 675 680 685 gca tgg gta cca gca cac aaa gga att gga gga aat gaa
caa gta gat 2112 Ala Trp Val Pro Ala His Lys Gly Ile Gly Gly Asn
Glu Gln Val Asp 690 695 700 aag ttg gtc agt gct gga atc agg aaa gta
cta ttt tta gat gga ata 2160 Lys Leu Val Ser Ala Gly Ile Arg Lys
Val Leu Phe Leu Asp Gly Ile 705 710 715 720 gat aag gcc caa gaa gaa
cat gag aaa tat cac agt aat tgg aga gca 2208 Asp Lys Ala Gln Glu
Glu His Glu Lys Tyr His Ser Asn Trp Arg Ala 725 730 735 atg gct agt
gat ttt aac cta cca cct gta gta gca aaa gaa ata gta 2256 Met Ala
Ser Asp Phe Asn Leu Pro Pro Val Val Ala Lys Glu Ile Val 740 745 750
gcc agc tgt gat aaa tgt cag cta aaa ggg gaa gcc atg cat gga caa
2304 Ala Ser Cys Asp Lys Cys Gln Leu Lys Gly Glu Ala Met His Gly
Gln 755 760 765 gta gac tgt agc cca gga ata tgg cag cta gat tgt aca
cat tta gaa 2352 Val Asp Cys Ser Pro Gly Ile Trp Gln Leu Asp Cys
Thr His Leu Glu 770 775 780 gga aaa gtt atc ttg gta gca gtt cat gta
gcc agt gga tat ata gaa 2400 Gly Lys Val Ile Leu Val Ala Val His
Val Ala Ser Gly Tyr Ile Glu 785 790 795 800 gca gaa gta att cca gca
gag aca ggg caa gaa aca gca tac ttc ctc 2448 Ala Glu Val Ile Pro
Ala Glu Thr Gly Gln Glu Thr Ala Tyr Phe Leu 805 810 815 tta aaa tta
gca gga aga tgg cca gta aaa aca gta cat aca gac aat 2496 Leu Lys
Leu Ala Gly Arg Trp Pro Val Lys Thr Val His Thr Asp Asn 820 825 830
ggc agc aat ttc acc agt act aca gtt aag gcc gcc tgt tgg tgg gcg
2544 Gly Ser Asn Phe Thr Ser Thr Thr Val Lys Ala Ala Cys Trp Trp
Ala 835 840 845 ggg atc aag cag gaa ttt ggc att ccc tac aat ccc caa
agt caa gga 2592 Gly Ile Lys Gln Glu Phe Gly Ile Pro Tyr Asn Pro
Gln Ser Gln Gly 850 855 860 gta ata gaa tct atg aat aaa gaa tta aag
aaa att ata gga cag gta 2640 Val Ile Glu Ser Met Asn Lys Glu Leu
Lys Lys Ile Ile Gly Gln Val 865 870 875 880 aga gat cag gct gaa cat
ctt aag aca gca gta caa atg gca gta ttc 2688 Arg Asp Gln Ala Glu
His Leu Lys Thr Ala Val Gln Met Ala Val Phe 885 890 895 atc cac aat
ttt aaa aga aaa ggg ggg att ggg ggg tac agt gca ggg 2736 Ile His
Asn Phe Lys Arg Lys Gly Gly Ile Gly Gly Tyr Ser Ala Gly 900 905 910
gaa aga ata gta gac ata ata gca aca gac ata caa act aaa gaa tta
2784 Glu Arg Ile Val Asp Ile Ile Ala Thr Asp Ile Gln Thr Lys Glu
Leu 915 920 925 caa aaa caa att aca aaa att caa aat ttt cgg gtt tat
tac agg gac 2832 Gln Lys Gln Ile Thr Lys Ile Gln Asn Phe Arg Val
Tyr Tyr Arg Asp 930 935 940 agc aga gat cca gtt tgg aaa gga cca gca
aag ctc ctc tgg aaa ggt 2880 Ser Arg Asp Pro Val Trp Lys Gly Pro
Ala Lys Leu Leu Trp Lys Gly 945 950 955 960 gaa ggg gca gta gta ata
caa gat aat agt gac ata aaa gta gtg cca 2928 Glu Gly Ala Val Val
Ile Gln Asp Asn Ser Asp Ile Lys Val Val Pro 965 970 975 aga aga aaa
gca aag atc atc agg gat tat gga aaa cag atg gca ggt 2976 Arg Arg
Lys Ala Lys Ile Ile Arg Asp Tyr Gly Lys Gln Met Ala Gly 980 985 990
gat gat tgt gtg gca agt aga cag gat gag gat taa 3012 Asp Asp Cys
Val Ala Ser Arg Gln Asp Glu Asp * 995 1000 9 1003 PRT Homo sapiens
9 Phe Phe Arg Glu Asp Leu Ala Phe Pro Gln Gly Lys Ala Arg Glu Phe 1
5 10 15 Ser Ser Glu Gln Thr Arg Ala Asn Ser Pro Thr Arg Arg Glu Leu
Gln 20 25 30 Val Trp Gly Arg Asp Asn Asn Ser Leu Ser Glu Ala Gly
Ala Asp Arg 35 40 45 Gln Gly Thr Val Ser Phe Ser Phe Pro Gln Ile
Thr Leu Trp Gln Arg 50 55 60 Pro Leu Val Thr Ile Lys Ile Gly Gly
Gln Leu Lys Glu Ala Leu Leu 65 70 75 80 Asp Thr Gly Ala Asp Asp Thr
Val Leu Glu Glu Met Asn Leu Pro Gly 85 90 95 Arg Trp Lys Pro Lys
Met Ile Gly Gly Ile Gly Gly Phe Ile Lys Val 100 105 110 Arg Gln Tyr
Asp Gln Ile Leu Ile Glu Ile Cys Gly His Lys Ala Ile 115 120 125 Gly
Thr Val Leu Val Gly Pro Thr Pro Val Asn Ile Ile Gly Arg Asn 130 135
140 Leu Leu Thr Gln Ile Gly Cys Thr Leu Asn Phe Pro Ile Ser Pro Ile
145 150 155 160 Glu Thr Val Pro Val Lys Leu Lys Pro Gly Met Asp Gly
Pro Lys Val 165 170 175 Lys Gln Trp Pro Leu Thr Glu Glu Lys Ile Lys
Ala Leu Val Glu Ile 180 185 190 Cys Thr Glu Met Glu Lys Glu Gly Lys
Ile Ser Lys Ile Gly Pro Glu 195 200 205 Asn Pro Tyr Asn Thr Pro Val
Phe Ala Ile Lys Lys Lys Asp Ser Thr 210 215 220 Lys Trp Arg Lys Leu
Val Asp Phe Arg Glu Leu Asn Lys Arg Thr Gln 225 230 235 240 Asp Phe
Trp Glu Val Gln Leu Gly Ile Pro His Pro Ala Gly Leu Lys 245 250 255
Gln Lys Lys Ser Val Thr Val Leu Asp Val Gly Asp Ala Tyr Phe Ser 260
265 270 Val Pro Leu Asp Lys Asp Phe Arg Lys Tyr Thr Ala Phe Thr Ile
Pro 275 280 285 Ser Ile Asn Asn Glu Thr Pro Gly Ile Arg Tyr Gln Tyr
Asn Val Leu 290 295 300 Pro Gln Gly Trp Lys Gly Ser Pro Ala Ile Phe
Gln Cys Ser Met Thr 305 310 315 320 Lys Ile Leu Glu Pro Phe Arg Lys
Gln Asn Pro Asp Ile Val Ile Tyr 325 330 335 Gln Tyr Met Asp Asp Leu
Tyr Val Gly Ser Asp Leu Glu Ile Gly Gln 340 345 350 His Arg Thr Lys
Ile Glu Glu Leu Arg Gln His Leu Leu Arg
Trp Gly 355 360 365 Phe Thr Thr Pro Asp Lys Lys His Gln Lys Glu Pro
Pro Phe Leu Trp 370 375 380 Met Gly Tyr Glu Leu His Pro Asp Lys Trp
Thr Val Gln Pro Ile Val 385 390 395 400 Leu Pro Glu Lys Asp Ser Trp
Thr Val Asn Asp Ile Gln Lys Leu Val 405 410 415 Gly Lys Leu Asn Trp
Ala Ser Gln Ile Tyr Ala Gly Ile Lys Val Arg 420 425 430 Gln Leu Cys
Lys Leu Leu Arg Gly Thr Lys Ala Leu Thr Glu Val Val 435 440 445 Pro
Leu Thr Glu Glu Ala Glu Leu Glu Leu Ala Glu Asn Arg Glu Ile 450 455
460 Leu Lys Glu Pro Val His Gly Val Tyr Tyr Asp Pro Ser Lys Asp Leu
465 470 475 480 Ile Ala Glu Ile Gln Lys Gln Gly Gln Gly Gln Trp Thr
Tyr Gln Ile 485 490 495 Tyr Gln Glu Pro Phe Lys Asn Leu Lys Thr Gly
Lys Tyr Ala Arg Met 500 505 510 Lys Gly Ala His Thr Asn Asp Val Lys
Gln Leu Thr Glu Ala Val Gln 515 520 525 Lys Ile Ala Thr Glu Ser Ile
Val Ile Trp Gly Lys Thr Pro Lys Phe 530 535 540 Lys Leu Pro Ile Gln
Lys Glu Thr Trp Glu Ala Trp Trp Thr Glu Tyr 545 550 555 560 Trp Gln
Ala Thr Trp Ile Pro Glu Trp Glu Phe Val Asn Thr Pro Pro 565 570 575
Leu Val Lys Leu Trp Tyr Gln Leu Glu Lys Glu Pro Ile Ile Gly Ala 580
585 590 Glu Thr Phe Tyr Val Asp Gly Ala Ala Asn Arg Glu Thr Lys Leu
Gly 595 600 605 Lys Ala Gly Tyr Val Thr Asp Arg Gly Arg Gln Lys Val
Val Pro Leu 610 615 620 Thr Asp Thr Thr Asn Gln Lys Thr Glu Leu Gln
Ala Ile His Leu Ala 625 630 635 640 Leu Gln Asp Ser Gly Leu Glu Val
Asn Ile Val Thr Asp Ser Gln Tyr 645 650 655 Ala Leu Gly Ile Ile Gln
Ala Gln Pro Asp Lys Ser Glu Ser Glu Leu 660 665 670 Val Ser Gln Ile
Ile Glu Gln Leu Ile Lys Lys Glu Lys Val Tyr Leu 675 680 685 Ala Trp
Val Pro Ala His Lys Gly Ile Gly Gly Asn Glu Gln Val Asp 690 695 700
Lys Leu Val Ser Ala Gly Ile Arg Lys Val Leu Phe Leu Asp Gly Ile 705
710 715 720 Asp Lys Ala Gln Glu Glu His Glu Lys Tyr His Ser Asn Trp
Arg Ala 725 730 735 Met Ala Ser Asp Phe Asn Leu Pro Pro Val Val Ala
Lys Glu Ile Val 740 745 750 Ala Ser Cys Asp Lys Cys Gln Leu Lys Gly
Glu Ala Met His Gly Gln 755 760 765 Val Asp Cys Ser Pro Gly Ile Trp
Gln Leu Asp Cys Thr His Leu Glu 770 775 780 Gly Lys Val Ile Leu Val
Ala Val His Val Ala Ser Gly Tyr Ile Glu 785 790 795 800 Ala Glu Val
Ile Pro Ala Glu Thr Gly Gln Glu Thr Ala Tyr Phe Leu 805 810 815 Leu
Lys Leu Ala Gly Arg Trp Pro Val Lys Thr Val His Thr Asp Asn 820 825
830 Gly Ser Asn Phe Thr Ser Thr Thr Val Lys Ala Ala Cys Trp Trp Ala
835 840 845 Gly Ile Lys Gln Glu Phe Gly Ile Pro Tyr Asn Pro Gln Ser
Gln Gly 850 855 860 Val Ile Glu Ser Met Asn Lys Glu Leu Lys Lys Ile
Ile Gly Gln Val 865 870 875 880 Arg Asp Gln Ala Glu His Leu Lys Thr
Ala Val Gln Met Ala Val Phe 885 890 895 Ile His Asn Phe Lys Arg Lys
Gly Gly Ile Gly Gly Tyr Ser Ala Gly 900 905 910 Glu Arg Ile Val Asp
Ile Ile Ala Thr Asp Ile Gln Thr Lys Glu Leu 915 920 925 Gln Lys Gln
Ile Thr Lys Ile Gln Asn Phe Arg Val Tyr Tyr Arg Asp 930 935 940 Ser
Arg Asp Pro Val Trp Lys Gly Pro Ala Lys Leu Leu Trp Lys Gly 945 950
955 960 Glu Gly Ala Val Val Ile Gln Asp Asn Ser Asp Ile Lys Val Val
Pro 965 970 975 Arg Arg Lys Ala Lys Ile Ile Arg Asp Tyr Gly Lys Gln
Met Ala Gly 980 985 990 Asp Asp Cys Val Ala Ser Arg Gln Asp Glu Asp
995 1000 10 3012 DNA Artificial Sequence Codon optimized form of
HIV pol coding region 10 ttt ttt agg gaa gat ctg gcc ttc cca caa
ggg aag gcc agg gaa ttt 48 Phe Phe Arg Glu Asp Leu Ala Phe Pro Gln
Gly Lys Ala Arg Glu Phe 1 5 10 15 tct tca gag cag acc aga gcc aac
agc ccc acc aga aga gag ctt cag 96 Ser Ser Glu Gln Thr Arg Ala Asn
Ser Pro Thr Arg Arg Glu Leu Gln 20 25 30 gtt tgg gga aga gac aac
aac tcc ctc tca gaa gca gga gcc gat aga 144 Val Trp Gly Arg Asp Asn
Asn Ser Leu Ser Glu Ala Gly Ala Asp Arg 35 40 45 caa gga act gta
tcc ttt agc ttc cct cag atc act ctt tgg cag cga 192 Gln Gly Thr Val
Ser Phe Ser Phe Pro Gln Ile Thr Leu Trp Gln Arg 50 55 60 ccc ctc
gtc aca ata aag atc ggt ggc cag ctg aag gag gcc ctg ctg 240 Pro Leu
Val Thr Ile Lys Ile Gly Gly Gln Leu Lys Glu Ala Leu Leu 65 70 75 80
gac acc ggc gcc gac gac acc gtg ctg gag gag atg aac ctg ccc ggc 288
Asp Thr Gly Ala Asp Asp Thr Val Leu Glu Glu Met Asn Leu Pro Gly 85
90 95 cgc tgg aag ccc aag atg atc ggc ggc atc ggc ggc ttc atc aaa
gtc 336 Arg Trp Lys Pro Lys Met Ile Gly Gly Ile Gly Gly Phe Ile Lys
Val 100 105 110 cgc cag tac gac cag atc ctg atc gag atc tgc ggc cac
aag gcc atc 384 Arg Gln Tyr Asp Gln Ile Leu Ile Glu Ile Cys Gly His
Lys Ala Ile 115 120 125 ggc acc gtg ctg gtg ggc ccc acc ccc gtg aac
atc atc ggc cgc aac 432 Gly Thr Val Leu Val Gly Pro Thr Pro Val Asn
Ile Ile Gly Arg Asn 130 135 140 ctg ctg acc cag atc ggc tgc acc ctg
aac ttc ccc atc tcc ccc atc 480 Leu Leu Thr Gln Ile Gly Cys Thr Leu
Asn Phe Pro Ile Ser Pro Ile 145 150 155 160 gag acc gtg ccc gtg aag
ctg aag ccc ggc atg gac ggc ccc aaa gtc 528 Glu Thr Val Pro Val Lys
Leu Lys Pro Gly Met Asp Gly Pro Lys Val 165 170 175 aag cag tgg ccc
ctg acc gag gag aag atc aag gcc ctg gtg gag atc 576 Lys Gln Trp Pro
Leu Thr Glu Glu Lys Ile Lys Ala Leu Val Glu Ile 180 185 190 tgc acc
gag atg gag aag gag ggc aag atc tcc aag atc ggc ccc gag 624 Cys Thr
Glu Met Glu Lys Glu Gly Lys Ile Ser Lys Ile Gly Pro Glu 195 200 205
aac ccc tac aac acc ccc gtg ttc gcc atc aag aag aag gac tcc acc 672
Asn Pro Tyr Asn Thr Pro Val Phe Ala Ile Lys Lys Lys Asp Ser Thr 210
215 220 aag tgg cgc aag ctg gtg gac ttc cgc gag ctg aac aag cgc acc
cag 720 Lys Trp Arg Lys Leu Val Asp Phe Arg Glu Leu Asn Lys Arg Thr
Gln 225 230 235 240 gac ttc tgg gag gtg cag ctg ggc atc ccc cac ccc
gcc ggc ctg aag 768 Asp Phe Trp Glu Val Gln Leu Gly Ile Pro His Pro
Ala Gly Leu Lys 245 250 255 cag aag aag tcc gtg acc gtg ctg gac gtg
ggc gac gcc tac ttc tcc 816 Gln Lys Lys Ser Val Thr Val Leu Asp Val
Gly Asp Ala Tyr Phe Ser 260 265 270 gtg ccc ctg gac aag gac ttc cgc
aag tac acc gcc ttc acc atc ccc 864 Val Pro Leu Asp Lys Asp Phe Arg
Lys Tyr Thr Ala Phe Thr Ile Pro 275 280 285 tcc atc aac aac gag acc
ccc ggc atc cgc tac cag tac aac gtg ctg 912 Ser Ile Asn Asn Glu Thr
Pro Gly Ile Arg Tyr Gln Tyr Asn Val Leu 290 295 300 ccc cag ggc tgg
aag ggc tcc ccc gcc atc ttc cag tgc tcc atg acc 960 Pro Gln Gly Trp
Lys Gly Ser Pro Ala Ile Phe Gln Cys Ser Met Thr 305 310 315 320 aag
atc ctg gag ccc ttc cgc aag cag aac ccc gac atc gtg atc tac 1008
Lys Ile Leu Glu Pro Phe Arg Lys Gln Asn Pro Asp Ile Val Ile Tyr 325
330 335 cag tac atg gac gac ctg tac gtg ggc tcc gac ctg gag atc ggc
cag 1056 Gln Tyr Met Asp Asp Leu Tyr Val Gly Ser Asp Leu Glu Ile
Gly Gln 340 345 350 cac cgc acc aag atc gag gag ctg cgc cag cac ctg
ctg cgc tgg ggc 1104 His Arg Thr Lys Ile Glu Glu Leu Arg Gln His
Leu Leu Arg Trp Gly 355 360 365 ttc acc acc ccc gac aag aag cac cag
aag gag ccc ccc ttc ctg tgg 1152 Phe Thr Thr Pro Asp Lys Lys His
Gln Lys Glu Pro Pro Phe Leu Trp 370 375 380 atg ggc tac gag ctg cac
ccc gac aag tgg acc gtg cag ccc atc gtg 1200 Met Gly Tyr Glu Leu
His Pro Asp Lys Trp Thr Val Gln Pro Ile Val 385 390 395 400 ctg ccc
gag aag gac tcc tgg acc gtg aac gac atc cag aag ctg gtg 1248 Leu
Pro Glu Lys Asp Ser Trp Thr Val Asn Asp Ile Gln Lys Leu Val 405 410
415 ggc aag ctg aac tgg gcc tcc cag atc tac gcc ggc atc aaa gtc cgc
1296 Gly Lys Leu Asn Trp Ala Ser Gln Ile Tyr Ala Gly Ile Lys Val
Arg 420 425 430 cag ctg tgc aag ctg ctg cgc ggc acc aag gcc ctg acc
gag gtg gtg 1344 Gln Leu Cys Lys Leu Leu Arg Gly Thr Lys Ala Leu
Thr Glu Val Val 435 440 445 ccc ctg acc gag gag gcc gag ctg gag ctg
gcc gag aac cgc gag atc 1392 Pro Leu Thr Glu Glu Ala Glu Leu Glu
Leu Ala Glu Asn Arg Glu Ile 450 455 460 ctg aag gag ccc gtg cac ggc
gtg tac tac gac ccc tcc aag gac ctg 1440 Leu Lys Glu Pro Val His
Gly Val Tyr Tyr Asp Pro Ser Lys Asp Leu 465 470 475 480 atc gcc gag
atc cag aag cag ggc cag ggc cag tgg acc tac cag atc 1488 Ile Ala
Glu Ile Gln Lys Gln Gly Gln Gly Gln Trp Thr Tyr Gln Ile 485 490 495
tac cag gag ccc ttc aag aac ctg aag acc ggc aaa tac gcc cgc atg
1536 Tyr Gln Glu Pro Phe Lys Asn Leu Lys Thr Gly Lys Tyr Ala Arg
Met 500 505 510 aag ggc gcc cac acc aac gac gtg aag cag ctg acc gag
gcc gtg cag 1584 Lys Gly Ala His Thr Asn Asp Val Lys Gln Leu Thr
Glu Ala Val Gln 515 520 525 aag atc gcc acc gag tcc atc gtg atc tgg
ggc aag act ccc aag ttc 1632 Lys Ile Ala Thr Glu Ser Ile Val Ile
Trp Gly Lys Thr Pro Lys Phe 530 535 540 aag ctg ccc atc cag aag gag
acc tgg gag gcc tgg tgg acc gag tac 1680 Lys Leu Pro Ile Gln Lys
Glu Thr Trp Glu Ala Trp Trp Thr Glu Tyr 545 550 555 560 tgg cag gcc
acc tgg atc ccc gag tgg gag ttc gtg aac acc ccc ccc 1728 Trp Gln
Ala Thr Trp Ile Pro Glu Trp Glu Phe Val Asn Thr Pro Pro 565 570 575
ctg gtg aag ctg tgg tac cag ctg gag aag gag ccc atc atc ggc gcc
1776 Leu Val Lys Leu Trp Tyr Gln Leu Glu Lys Glu Pro Ile Ile Gly
Ala 580 585 590 gag acc ttc tac gtg gac ggc gcc gcc aac cgc gag acc
aag ctg ggc 1824 Glu Thr Phe Tyr Val Asp Gly Ala Ala Asn Arg Glu
Thr Lys Leu Gly 595 600 605 aag gcc ggc tac gtg acc gac cgc ggc cgc
cag aag gtg gtg ccc ctg 1872 Lys Ala Gly Tyr Val Thr Asp Arg Gly
Arg Gln Lys Val Val Pro Leu 610 615 620 acc gac acc acc aac cag aag
acc gag ctg cag gcc atc cac ctg gcc 1920 Thr Asp Thr Thr Asn Gln
Lys Thr Glu Leu Gln Ala Ile His Leu Ala 625 630 635 640 ctg caa gac
tcc ggc ctg gag gtg aac atc gtg acc gac tcc cag tat 1968 Leu Gln
Asp Ser Gly Leu Glu Val Asn Ile Val Thr Asp Ser Gln Tyr 645 650 655
gca ttg ggc atc atc cag gcc cag ccc gac aag tcc gag tcc gag ctg
2016 Ala Leu Gly Ile Ile Gln Ala Gln Pro Asp Lys Ser Glu Ser Glu
Leu 660 665 670 gtg tcc cag atc atc gag cag ctg atc aag aag gag aag
gtg tac ctg 2064 Val Ser Gln Ile Ile Glu Gln Leu Ile Lys Lys Glu
Lys Val Tyr Leu 675 680 685 gcc tgg gtg ccc gcc cac aag ggc atc ggc
ggc aac gag cag gtg gac 2112 Ala Trp Val Pro Ala His Lys Gly Ile
Gly Gly Asn Glu Gln Val Asp 690 695 700 aag ctg gtg tcc gcc ggc atc
cgc aag gtg ctg ttc ctg gac ggc atc 2160 Lys Leu Val Ser Ala Gly
Ile Arg Lys Val Leu Phe Leu Asp Gly Ile 705 710 715 720 gac aag gcc
cag gag gag cac gag aag tac cac tcc aac tgg cgc gcc 2208 Asp Lys
Ala Gln Glu Glu His Glu Lys Tyr His Ser Asn Trp Arg Ala 725 730 735
atg gcc tcc gac ttc aac ctg ccc ccc gtg gtg gcc aag gag atc gtg
2256 Met Ala Ser Asp Phe Asn Leu Pro Pro Val Val Ala Lys Glu Ile
Val 740 745 750 gcc tcc tgc gac aag tgc cag ctg aag ggc gag gcc atg
cac ggc cag 2304 Ala Ser Cys Asp Lys Cys Gln Leu Lys Gly Glu Ala
Met His Gly Gln 755 760 765 gtg gac tgc tcc ccc ggc atc tgg cag ctg
gac tgc acc cac ctg gag 2352 Val Asp Cys Ser Pro Gly Ile Trp Gln
Leu Asp Cys Thr His Leu Glu 770 775 780 ggc aag gtg atc ctg gtg gcc
gtg cac gtg gcc tcc ggc tac atc gag 2400 Gly Lys Val Ile Leu Val
Ala Val His Val Ala Ser Gly Tyr Ile Glu 785 790 795 800 gcc gag gtg
atc ccc gcc gag acc ggc cag gag acc gcc tac ttc ctg 2448 Ala Glu
Val Ile Pro Ala Glu Thr Gly Gln Glu Thr Ala Tyr Phe Leu 805 810 815
ctg aag ctg gcc ggc cgc tgg ccc gtg aag acc gtg cac acc gac aac
2496 Leu Lys Leu Ala Gly Arg Trp Pro Val Lys Thr Val His Thr Asp
Asn 820 825 830 ggc tcc aac ttc acc tcc acc acc gtg aag gcc gcc tgc
tgg tgg gcc 2544 Gly Ser Asn Phe Thr Ser Thr Thr Val Lys Ala Ala
Cys Trp Trp Ala 835 840 845 ggc atc aag cag gag ttc ggc atc ccc tac
aac ccc cag tcc cag ggc 2592 Gly Ile Lys Gln Glu Phe Gly Ile Pro
Tyr Asn Pro Gln Ser Gln Gly 850 855 860 gtg atc gag tcc atg aac aag
gag ctg aag aag atc atc ggc caa gtc 2640 Val Ile Glu Ser Met Asn
Lys Glu Leu Lys Lys Ile Ile Gly Gln Val 865 870 875 880 cgc gac cag
gcc gag cac ctg aag acc gcc gtg cag atg gcc gtg ttc 2688 Arg Asp
Gln Ala Glu His Leu Lys Thr Ala Val Gln Met Ala Val Phe 885 890 895
atc cac aac ttc aag cgc aag ggc ggc atc ggc ggc tac tcc gcc ggc
2736 Ile His Asn Phe Lys Arg Lys Gly Gly Ile Gly Gly Tyr Ser Ala
Gly 900 905 910 gag cgc atc gtg gac atc atc gcc acc gac atc cag acc
aag gag ctg 2784 Glu Arg Ile Val Asp Ile Ile Ala Thr Asp Ile Gln
Thr Lys Glu Leu 915 920 925 cag aag cag atc acc aag atc cag aac ttc
cgc gtg tac tac cgc gac 2832 Gln Lys Gln Ile Thr Lys Ile Gln Asn
Phe Arg Val Tyr Tyr Arg Asp 930 935 940 tcc cgc gac ccc gtg tgg aag
ggc ccc gcc aag ctg ctg tgg aag ggc 2880 Ser Arg Asp Pro Val Trp
Lys Gly Pro Ala Lys Leu Leu Trp Lys Gly 945 950 955 960 gag ggc gcc
gtg gtg atc cag gac aac tcc gac atc aag gtg gtg ccc 2928 Glu Gly
Ala Val Val Ile Gln Asp Asn Ser Asp Ile Lys Val Val Pro 965 970 975
cgc cgc aag gcc aag atc atc cgc gac tac ggc aag cag atg gcc ggc
2976 Arg Arg Lys Ala Lys Ile Ile Arg Asp Tyr Gly Lys Gln Met Ala
Gly 980 985 990 gac gac tgc gtg gcc tcc cgc cag gac gag gac taa
3012 Asp Asp Cys Val Ala Ser Arg Gln Asp Glu Asp * 995 1000 11 1003
PRT Artificial Sequence Codon optimized form of HIV pol coding
region 11 Phe Phe Arg Glu Asp Leu Ala Phe Pro Gln Gly Lys Ala Arg
Glu Phe 1 5 10 15 Ser Ser Glu Gln Thr Arg Ala Asn Ser Pro Thr Arg
Arg Glu Leu Gln 20 25 30 Val Trp Gly Arg Asp Asn Asn Ser Leu Ser
Glu Ala Gly Ala Asp Arg 35 40 45 Gln Gly Thr Val Ser Phe Ser Phe
Pro Gln Ile Thr Leu Trp Gln Arg 50 55 60 Pro Leu Val Thr Ile Lys
Ile Gly Gly Gln Leu Lys Glu Ala Leu Leu 65 70 75 80 Asp Thr Gly Ala
Asp Asp Thr Val Leu Glu Glu Met Asn Leu Pro Gly 85 90 95 Arg Trp
Lys Pro Lys Met Ile Gly Gly Ile Gly Gly Phe Ile Lys Val 100 105 110
Arg Gln Tyr Asp Gln Ile Leu Ile Glu Ile Cys Gly His Lys Ala Ile 115
120 125 Gly Thr Val Leu Val Gly Pro Thr Pro Val Asn Ile Ile Gly Arg
Asn 130 135 140 Leu Leu Thr Gln Ile Gly Cys Thr Leu Asn Phe Pro Ile
Ser Pro Ile 145 150 155 160 Glu Thr Val Pro Val Lys Leu Lys Pro Gly
Met Asp Gly Pro Lys
Val 165 170 175 Lys Gln Trp Pro Leu Thr Glu Glu Lys Ile Lys Ala Leu
Val Glu Ile 180 185 190 Cys Thr Glu Met Glu Lys Glu Gly Lys Ile Ser
Lys Ile Gly Pro Glu 195 200 205 Asn Pro Tyr Asn Thr Pro Val Phe Ala
Ile Lys Lys Lys Asp Ser Thr 210 215 220 Lys Trp Arg Lys Leu Val Asp
Phe Arg Glu Leu Asn Lys Arg Thr Gln 225 230 235 240 Asp Phe Trp Glu
Val Gln Leu Gly Ile Pro His Pro Ala Gly Leu Lys 245 250 255 Gln Lys
Lys Ser Val Thr Val Leu Asp Val Gly Asp Ala Tyr Phe Ser 260 265 270
Val Pro Leu Asp Lys Asp Phe Arg Lys Tyr Thr Ala Phe Thr Ile Pro 275
280 285 Ser Ile Asn Asn Glu Thr Pro Gly Ile Arg Tyr Gln Tyr Asn Val
Leu 290 295 300 Pro Gln Gly Trp Lys Gly Ser Pro Ala Ile Phe Gln Cys
Ser Met Thr 305 310 315 320 Lys Ile Leu Glu Pro Phe Arg Lys Gln Asn
Pro Asp Ile Val Ile Tyr 325 330 335 Gln Tyr Met Asp Asp Leu Tyr Val
Gly Ser Asp Leu Glu Ile Gly Gln 340 345 350 His Arg Thr Lys Ile Glu
Glu Leu Arg Gln His Leu Leu Arg Trp Gly 355 360 365 Phe Thr Thr Pro
Asp Lys Lys His Gln Lys Glu Pro Pro Phe Leu Trp 370 375 380 Met Gly
Tyr Glu Leu His Pro Asp Lys Trp Thr Val Gln Pro Ile Val 385 390 395
400 Leu Pro Glu Lys Asp Ser Trp Thr Val Asn Asp Ile Gln Lys Leu Val
405 410 415 Gly Lys Leu Asn Trp Ala Ser Gln Ile Tyr Ala Gly Ile Lys
Val Arg 420 425 430 Gln Leu Cys Lys Leu Leu Arg Gly Thr Lys Ala Leu
Thr Glu Val Val 435 440 445 Pro Leu Thr Glu Glu Ala Glu Leu Glu Leu
Ala Glu Asn Arg Glu Ile 450 455 460 Leu Lys Glu Pro Val His Gly Val
Tyr Tyr Asp Pro Ser Lys Asp Leu 465 470 475 480 Ile Ala Glu Ile Gln
Lys Gln Gly Gln Gly Gln Trp Thr Tyr Gln Ile 485 490 495 Tyr Gln Glu
Pro Phe Lys Asn Leu Lys Thr Gly Lys Tyr Ala Arg Met 500 505 510 Lys
Gly Ala His Thr Asn Asp Val Lys Gln Leu Thr Glu Ala Val Gln 515 520
525 Lys Ile Ala Thr Glu Ser Ile Val Ile Trp Gly Lys Thr Pro Lys Phe
530 535 540 Lys Leu Pro Ile Gln Lys Glu Thr Trp Glu Ala Trp Trp Thr
Glu Tyr 545 550 555 560 Trp Gln Ala Thr Trp Ile Pro Glu Trp Glu Phe
Val Asn Thr Pro Pro 565 570 575 Leu Val Lys Leu Trp Tyr Gln Leu Glu
Lys Glu Pro Ile Ile Gly Ala 580 585 590 Glu Thr Phe Tyr Val Asp Gly
Ala Ala Asn Arg Glu Thr Lys Leu Gly 595 600 605 Lys Ala Gly Tyr Val
Thr Asp Arg Gly Arg Gln Lys Val Val Pro Leu 610 615 620 Thr Asp Thr
Thr Asn Gln Lys Thr Glu Leu Gln Ala Ile His Leu Ala 625 630 635 640
Leu Gln Asp Ser Gly Leu Glu Val Asn Ile Val Thr Asp Ser Gln Tyr 645
650 655 Ala Leu Gly Ile Ile Gln Ala Gln Pro Asp Lys Ser Glu Ser Glu
Leu 660 665 670 Val Ser Gln Ile Ile Glu Gln Leu Ile Lys Lys Glu Lys
Val Tyr Leu 675 680 685 Ala Trp Val Pro Ala His Lys Gly Ile Gly Gly
Asn Glu Gln Val Asp 690 695 700 Lys Leu Val Ser Ala Gly Ile Arg Lys
Val Leu Phe Leu Asp Gly Ile 705 710 715 720 Asp Lys Ala Gln Glu Glu
His Glu Lys Tyr His Ser Asn Trp Arg Ala 725 730 735 Met Ala Ser Asp
Phe Asn Leu Pro Pro Val Val Ala Lys Glu Ile Val 740 745 750 Ala Ser
Cys Asp Lys Cys Gln Leu Lys Gly Glu Ala Met His Gly Gln 755 760 765
Val Asp Cys Ser Pro Gly Ile Trp Gln Leu Asp Cys Thr His Leu Glu 770
775 780 Gly Lys Val Ile Leu Val Ala Val His Val Ala Ser Gly Tyr Ile
Glu 785 790 795 800 Ala Glu Val Ile Pro Ala Glu Thr Gly Gln Glu Thr
Ala Tyr Phe Leu 805 810 815 Leu Lys Leu Ala Gly Arg Trp Pro Val Lys
Thr Val His Thr Asp Asn 820 825 830 Gly Ser Asn Phe Thr Ser Thr Thr
Val Lys Ala Ala Cys Trp Trp Ala 835 840 845 Gly Ile Lys Gln Glu Phe
Gly Ile Pro Tyr Asn Pro Gln Ser Gln Gly 850 855 860 Val Ile Glu Ser
Met Asn Lys Glu Leu Lys Lys Ile Ile Gly Gln Val 865 870 875 880 Arg
Asp Gln Ala Glu His Leu Lys Thr Ala Val Gln Met Ala Val Phe 885 890
895 Ile His Asn Phe Lys Arg Lys Gly Gly Ile Gly Gly Tyr Ser Ala Gly
900 905 910 Glu Arg Ile Val Asp Ile Ile Ala Thr Asp Ile Gln Thr Lys
Glu Leu 915 920 925 Gln Lys Gln Ile Thr Lys Ile Gln Asn Phe Arg Val
Tyr Tyr Arg Asp 930 935 940 Ser Arg Asp Pro Val Trp Lys Gly Pro Ala
Lys Leu Leu Trp Lys Gly 945 950 955 960 Glu Gly Ala Val Val Ile Gln
Asp Asn Ser Asp Ile Lys Val Val Pro 965 970 975 Arg Arg Lys Ala Lys
Ile Ile Arg Asp Tyr Gly Lys Gln Met Ala Gly 980 985 990 Asp Asp Cys
Val Ala Ser Arg Gln Asp Glu Asp 995 1000 12 8908 DNA Artificial
Sequence Packaging construct pHDmHgpm2 comprising a codon optimized
form of HIV gag pol region 12 agcttggccc attgcatacg ttgtatccat
atcataatat gtacatttat attggctcat 60 gtccaacatt accgccatgt
tgacattgat tattgactag ttattaatag taatcaatta 120 cggggtcatt
agttcatagc ccatatatgg agttccgcgt tacataactt acggtaaatg 180
gcccgcctgg ctgaccgccc aacgaccccc gcccattgac gtcaataatg acgtatgttc
240 ccatagtaac gccaataggg actttccatt gacgtcaatg ggtggagtat
ttacggtaaa 300 ctgcccactt ggcagtacat caagtgtatc atatgccaag
tacgccccct attgacgtca 360 atgacggtaa atggcccgcc tggcattatg
cccagtacat gaccttatgg gactttccta 420 cttggcagta catctacgta
ttagtcatcg ctattaccat ggtgatgcgg ttttggcagt 480 acatcaatgg
gcgtggatag cggtttgact cacggggatt tccaagtctc caccccattg 540
acgtcaatgg gagtttgttt tggcaccaaa atcaacggga ctttccaaaa tgtcgtaaca
600 actccgcccc attgacgcaa atgggcggta ggcgtgtacg gtgggaggtc
tatataagca 660 gagctcgttt agtgaaccgt cagatcgcct ggagacgcca
tccacgctgt tttgacctcc 720 atagaagaca ccgggaccga tccagcctcc
cctcgaagct gatcctgaga acttcagggt 780 gagtctatgg gacccttgat
gttttctttc cccttctttt ctatggttaa gttcatgtca 840 taggaagggg
agaagtaaca gggtacacat attgaccaaa tcagggtaat tttgcatttg 900
taattttaaa aaatgctttc ttcttttaat atactttttt gtttatctta tttctaatac
960 tttccctaat ctctttcttt cagggcaata atgatacaat gtatcatgcc
tctttgcacc 1020 attctaaaga ataacagtga taatttctgg gttaaggcaa
tagcaatatt tctgcatata 1080 aatatttctg catataaatt gtaactgatg
taagaggttt catattgcta atagcagcta 1140 caatccagct accattctgc
ttttatttta tggttgggat aaggctggat tattctgagt 1200 ccaagctagg
cccttttgct aatcatgttc atacctctta tcttcctccc acagctcctg 1260
ggcaacgtgc tggtctgtgt gctggcccat cactttggca aagaattcta gactgccatg
1320 ggcgcccgcg cctccgtgct gtccggcggc gagctggaca agtgggagaa
gatccgcctg 1380 cgccccggcg gcaagaagca gtacaagctg aagcacatcg
tgtgggcctc ccgcgagctg 1440 gagcgcttcg ccgtgaaccc cggcctgctg
gagacctccg agggctgccg ccagatcctg 1500 ggccagctgc agccctccct
gcaaaccggc tccgaggagc tgcgctccct gtacaacacc 1560 atcgccgtgc
tgtactgcgt gcaccagcgc atcgacgtga aggacaccaa ggaggccctg 1620
gacaagatcg aggaggagca gaacaagtcc aagaagaagg cccagcaggc cgccgccgac
1680 accggcaaca actcccaggt gtcccagaac taccccatcg tgcagaacct
gcagggccag 1740 atggtgcacc aggccatctc cccccgcacc ctgaacgcct
gggtgaaggt ggtggaggag 1800 aaggccttct cccccgaagt catccccatg
ttctccgccc tgtccgaggg cgccaccccc 1860 caggacctga acaccatgct
gaacaccgtg ggcggccacc aggccgccat gcagatgctg 1920 aaggagacca
tcaacgagga ggccgccgag tgggaccgcc tgcaccccgt gcacgccggc 1980
cccatcgccc ccggccagat gcgcgagccc cgcggctccg acatcgccgg caccacctcc
2040 accctgcaag agcagatcgg ctggatgacc cacaaccccc ccatccccgt
gggcgagatc 2100 tacaagcgct ggatcatcct gggcctgaac aagatcgtgc
gcatgtactc ccccacctcc 2160 atcctggaca tccgccaggg ccccaaggag
cccttccgcg actacgtgga ccgcttctac 2220 aagaccctgc gcgccgagca
ggcctcccag gaggtaaaga actggatgac cgagaccctg 2280 ctggtgcaga
acgccaaccc cgactgcaag accatcctga aggccctggg ccccggcgcc 2340
accctggagg agatgatgac cgcctgccag ggcgtgggcg gccccggcca caaggcccgc
2400 gtgctggccg aggccatgtc ccaagtcacc aaccccgcca ccatcatgat
ccagaagggc 2460 aacttccgca accagcgcaa gaccgtgaag tgcttcaact
gcggcaagga gggccacatc 2520 gccaagaact gccgcgcccc ccgcaagaag
ggctgctgga agtgcggcaa ggagggccac 2580 cagatgaaag attgtactga
gagacaggct aattttttag ggaagatctg gccttcccac 2640 aagggaaggc
cagggaattt tcttcagagc agaccagagc caacagcccc accagaagag 2700
agcttcaggt ttggggaaga gacaacaact ccctctcaga agcaggagcc gatagacaag
2760 gaactgtatc ctttagcttc cctcagatca ctctttggca gcgacccctc
gtcacaataa 2820 agatcggtgg ccagctgaag gaggccctgc tggacaccgg
cgccgacgac accgtgctgg 2880 aggagatgaa cctgcccggc cgctggaagc
ccaagatgat cggcggcatc ggcggcttca 2940 tcaaagtccg ccagtacgac
cagatcctga tcgagatctg cggccacaag gccatcggca 3000 ccgtgctggt
gggccccacc cccgtgaaca tcatcggccg caacctgctg acccagatcg 3060
gctgcaccct gaacttcccc atctccccca tcgagaccgt gcccgtgaag ctgaagcccg
3120 gcatggacgg ccccaaagtc aagcagtggc ccctgaccga ggagaagatc
aaggccctgg 3180 tggagatctg caccgagatg gagaaggagg gcaagatctc
caagatcggc cccgagaacc 3240 cctacaacac ccccgtgttc gccatcaaga
agaaggactc caccaagtgg cgcaagctgg 3300 tggacttccg cgagctgaac
aagcgcaccc aggacttctg ggaggtgcag ctgggcatcc 3360 cccaccccgc
cggcctgaag cagaagaagt ccgtgaccgt gctggacgtg ggcgacgcct 3420
acttctccgt gcccctggac aaggacttcc gcaagtacac cgccttcacc atcccctcca
3480 tcaacaacga gacccccggc atccgctacc agtacaacgt gctgccccag
ggctggaagg 3540 gctcccccgc catcttccag tgctccatga ccaagatcct
ggagcccttc cgcaagcaga 3600 accccgacat cgtgatctac cagtacatgg
acgacctgta cgtgggctcc gacctggaga 3660 tcggccagca ccgcaccaag
atcgaggagc tgcgccagca cctgctgcgc tggggcttca 3720 ccacccccga
caagaagcac cagaaggagc cccccttcct gtggatgggc tacgagctgc 3780
accccgacaa gtggaccgtg cagcccatcg tgctgcccga gaaggactcc tggaccgtga
3840 acgacatcca gaagctggtg ggcaagctga actgggcctc ccagatctac
gccggcatca 3900 aagtccgcca gctgtgcaag ctgctgcgcg gcaccaaggc
cctgaccgag gtggtgcccc 3960 tgaccgagga ggccgagctg gagctggccg
agaaccgcga gatcctgaag gagcccgtgc 4020 acggcgtgta ctacgacccc
tccaaggacc tgatcgccga gatccagaag cagggccagg 4080 gccagtggac
ctaccagatc taccaggagc ccttcaagaa cctgaagacc ggcaaatacg 4140
cccgcatgaa gggcgcccac accaacgacg tgaagcagct gaccgaggcc gtgcagaaga
4200 tcgccaccga gtccatcgtg atctggggca agactcccaa gttcaagctg
cccatccaga 4260 aggagacctg ggaggcctgg tggaccgagt actggcaggc
cacctggatc cccgagtggg 4320 agttcgtgaa cacccccccc ctggtgaagc
tgtggtacca gctggagaag gagcccatca 4380 tcggcgccga gaccttctac
gtggacggcg ccgccaaccg cgagaccaag ctgggcaagg 4440 ccggctacgt
gaccgaccgc ggccgccaga aggtggtgcc cctgaccgac accaccaacc 4500
agaagaccga gctgcaggcc atccacctgg ccctgcaaga ctccggcctg gaggtgaaca
4560 tcgtgaccga ctcccagtat gcattgggca tcatccaggc ccagcccgac
aagtccgagt 4620 ccgagctggt gtcccagatc atcgagcagc tgatcaagaa
ggagaaggtg tacctggcct 4680 gggtgcccgc ccacaagggc atcggcggca
acgagcaggt ggacaagctg gtgtccgccg 4740 gcatccgcaa ggtgctgttc
ctggacggca tcgacaaggc ccaggaggag cacgagaagt 4800 accactccaa
ctggcgcgcc atggcctccg acttcaacct gccccccgtg gtggccaagg 4860
agatcgtggc ctcctgcgac aagtgccagc tgaagggcga ggccatgcac ggccaggtgg
4920 actgctcccc cggcatctgg cagctggact gcacccacct ggagggcaag
gtgatcctgg 4980 tggccgtgca cgtggcctcc ggctacatcg aggccgaggt
gatccccgcc gagaccggcc 5040 aggagaccgc ctacttcctg ctgaagctgg
ccggccgctg gcccgtgaag accgtgcaca 5100 ccgacaacgg ctccaacttc
acctccacca ccgtgaaggc cgcctgctgg tgggccggca 5160 tcaagcagga
gttcggcatc ccctacaacc cccagtccca gggcgtgatc gagtccatga 5220
acaaggagct gaagaagatc atcggccaag tccgcgacca ggccgagcac ctgaagaccg
5280 ccgtgcagat ggccgtgttc atccacaact tcaagcgcaa gggcggcatc
ggcggctact 5340 ccgccggcga gcgcatcgtg gacatcatcg ccaccgacat
ccagaccaag gagctgcaga 5400 agcagatcac caagatccag aacttccgcg
tgtactaccg cgactcccgc gaccccgtgt 5460 ggaagggccc cgccaagctg
ctgtggaagg gcgagggcgc cgtggtgatc caggacaact 5520 ccgacatcaa
ggtggtgccc cgccgcaagg ccaagatcat ccgcgactac ggcaagcaga 5580
tggccggcga cgactgcgtg gcctcccgcc aggacgagga ctaacacatg gaaaagatta
5640 gtaaaacacc ataggccgct ctagaggatc caagcttatc gataccgtcg
acctcgaggg 5700 cccagatcta attcacccca ccagtgcagg ctgcctatca
gaaagtggtg gctggtgtgg 5760 ctaatgccct ggcccacaag tatcactaag
ctcgctttct tgctgtccaa tttctattaa 5820 aggttccttt gttccctaag
tccaactact aaactggggg atattatgaa gggccttgag 5880 catctggatt
ctgcctaata aaaaacattt attttcattg caatgatgta tttaaattat 5940
ttctgaatat tttactaaaa agggaatgtg ggaggtcagt gcatttaaaa cataaagaaa
6000 tgaagagcta gttcaaacct tgggaaaata cactatatct taaactccat
gaaagaaggt 6060 gaggctgcaa acagctaatg cacattggca acagcccctg
atgcctatgc cttattcatc 6120 cctcagaaaa ggattcaagt agaggcttga
tttggaggtt aaagttttgc tatgctgtat 6180 tttacattac ttattgtttt
agctgtcctc atgaatgtct tttcactacc catttgctta 6240 tcctgcatct
ctcagccttg actccactca gttctcttgc ttagagatac cacctttccc 6300
ctgaagtgtt ccttccatgt tttacggcga gatggtttct cctcgcctgg ccactcagcc
6360 ttagttgtct ctgttgtctt atagaggtct acttgaagaa ggaaaaacag
ggggcatggt 6420 ttgactgtcc tgtgagccct tcttccctgc ctcccccact
cacagtgacc cggaatccct 6480 cgacatggca gtctagatca ttcttgaaga
cgaaagggcc tcgtgatacg cctattttta 6540 taggttaatg tcatgataat
aatggtttct tagacgtcag gtggcacttt tcggggaaat 6600 gtgcgcggaa
cccctatttg tttatttttc taaatacatt caaatatgta tccgctcatg 6660
agacaataac cctgataaat gcttcaataa tattgaaaaa ggaagagtat gagtattcaa
6720 catttccgtg tcgcccttat tccctttttt gcggcatttt gccttcctgt
ttttgctcac 6780 ccagaaacgc tggtgaaagt aaaagatgct gaagatcagt
tgggtgcacg agtgggttac 6840 atcgaactgg atctcaacag cggtaagatc
cttgagagtt ttcgccccga agaacgtttt 6900 ccaatgatga gcacttttaa
agttctgcta tgtggcgcgg tattatcccg tattgacgcc 6960 gggcaagagc
aactcggtcg ccgcatacac tattctcaga atgacttggt tgagtactca 7020
ccagtcacag aaaagcatct tacggatggc atgacagtaa gagaattatg cagtgctgcc
7080 ataaccatga gtgataacac tgcggccaac ttacttctga caacgatcgg
aggaccgaag 7140 gagctaaccg cttttttgca caacatgggg gatcatgtaa
ctcgccttga tcgttgggaa 7200 ccggagctga atgaagccat accaaacgac
gagcgtgaca ccacgatgcc tgtagcaatg 7260 gcaacaacgt tgcgcaaact
attaactggc gaactactta ctctagcttc ccggcaacaa 7320 ttaatagact
ggatggaggc ggataaagtt gcaggaccac ttctgcgctc ggcccttccg 7380
gctggctggt ttattgctga taaatctgga gccggtgagc gtgggtctcg cggtatcatt
7440 gcagcactgg ggccagatgg taagccctcc cgtatcgtag ttatctacac
gacggggagt 7500 caggcaacta tggatgaacg aaatagacag atcgctgaga
taggtgcctc actgattaag 7560 cattggtaac tgtcagacca agtttactca
tatatacttt agattgattt aaaacttcat 7620 ttttaattta aaaggatcta
ggtgaagatc ctttttgata atctcatgac caaaatccct 7680 taacgtgagt
tttcgttcca ctgagcgtca gaccccgtag aaaagatcaa aggatcttct 7740
tgagatcctt tttttctgcg cgtaatctgc tgcttgcaaa caaaaaaacc accgctacca
7800 gcggtggttt gtttgccgga tcaagagcta ccaactcttt ttccgaaggt
aactggcttc 7860 agcagagcgc agataccaaa tactgttctt ctagtgtagc
cgtagttagg ccaccacttc 7920 aagaactctg tagcaccgcc tacatacctc
gctctgctaa tcctgttacc agtggctgct 7980 gccagtggcg ataagtcgtg
tcttaccggg ttggactcaa gacgatagtt accggataag 8040 gcgcagcggt
cgggctgaac ggggggttcg tgcacacagc ccagcttgga gcgaacgacc 8100
tacaccgaac tgagatacct acagcgtgag ctatgagaaa gcgccacgct tcccgaaggg
8160 agaaaggcgg acaggtatcc ggtaagcggc agggtcggaa caggagagcg
cacgagggag 8220 cttccagggg gaaacgcctg gtatctttat agtcctgtcg
ggtttcgcca cctctgactt 8280 gagcgtcgat ttttgtgatg ctcgtcaggg
gggcggagcc tatggaaaaa cgccagcaac 8340 ggatgcgccg cgtgcggctg
ctggagatgg cggacgcgat ggatatgttc tgccaagggt 8400 tggtttgcgc
attcacagtt ctccgcaaga attgattggc tccaattctt ggagtggtga 8460
atccgttagc gaggtgccgc cggcttccat tcaggtcgag gtggcccggc tccatgcacc
8520 gcgacgcaac gcggggaggc agacaaggta tagggcggcg cctacaatcc
atgccaaccc 8580 gttccatgtg ctcgccgagg cggcataaat ccccgtgacg
atcagcggtc caatgatcga 8640 agttaggctg gtaagagccg cgagcgatcc
ttgaagctgt ccctgatggt cgtcatctac 8700 ctgcctggac agcatggcct
gcaacgcggg catcccgatg ccgccggaag cgagaagaat 8760 cataatgggg
aaggccatcc agcctcgcgt cggggagctt tttgcaaaag cctaggcctc 8820
caaaaaagcc tcctcactac ttctggaata gctcagaggc cgaggcggcc tcggcctctg
8880 cataaataaa aaaaattagt cagccatg 8908
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