U.S. patent application number 11/022478 was filed with the patent office on 2006-02-16 for notch. This patent application is currently assigned to Lorantis Limited. Invention is credited to Margaret Jane Dallman, Gerard Francis Hoyne, Jonathan Robert Lamb.
Application Number | 20060034857 11/022478 |
Document ID | / |
Family ID | 33458905 |
Filed Date | 2006-02-16 |
United States Patent Application | 20060034857 |
Kind Code | A1 |
Lamb; Jonathan Robert ; et al. | February 16, 2006 |
The present invention relates to the use of therapeutic compounds in the modification of T-cell, T-cell antigen presenting cell (APC) interactions and the interactions between pathogenic organisms and immunocompetent cells of a host. In particular it relates to the use of these compounds in the modulation of the interaction between Notch proteins and their ligand and to the use of such compounds in the therapy of conditions such as graft rejection, autoimmunity, allergy, and asthma and infectious diseases.
Inventors: | Lamb; Jonathan Robert; (Edinburgh, GB) ; Dallman; Margaret Jane; (London, GB) ; Hoyne; Gerard Francis; (Mussellburgh, GB) |
Correspondence Address: |
FROMMER LAWRENCE & HAUG 745 FIFTH AVENUE- 10TH FL. NEW YORK NY 10151 US |
Assignee: | Lorantis Limited |
Family ID: | 33458905 |
Appl. No.: | 11/022478 |
Filed: | December 22, 2004 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
09310685 | May 4, 1999 | 6887475 | ||
11022478 | Dec 22, 2004 | |||
PCT/GB97/03058 | Nov 6, 1997 | |||
09310685 | May 4, 1999 | |||
Current U.S. Class: | 424/185.1 ; 530/350 |
Current CPC Class: | Y10S 424/81 20130101; C07K 2319/00 20130101; A61K 2039/5154 20130101; Y02A 50/412 20180101; Y02A 50/30 20180101; C07K 14/705 20130101; G01N 33/505 20130101; C12N 2799/027 20130101; A61K 38/00 20130101 |
Class at Publication: | 424/185.1 ; 530/350 |
International Class: | A61K 39/00 20060101 A61K039/00; C07K 14/705 20060101 C07K014/705 |
Date | Code | Application Number |
---|---|---|
Nov 7, 1996 | GB | 9623236.8 |
Jul 24, 1997 | GB | 9715674.9 |
Sep 11, 1997 | GB | 9719350.2 |
Sequence CWU 0
0
SEQUENCE LISTING <160> NUMBER OF SEQ ID NOS: 32 <210>
SEQ ID NO 1 <211> LENGTH: 2892 <212> TYPE: DNA
<213> ORGANISM: Drosophila sp. <400> SEQUENCE: 1
gaattcggag gaattattca aaacataaac acaataaaca atttgagtag ttgccgcaca
60 cacacacaca cacagcccgt ggattattac actaaaagcg acactcaatc
caaaaaatca 120 gcaacaaaaa catcaataaa catgcattgg attaaatgtt
tattaacagc attcatttgc 180 ttcacagtca tcgtgcaggt tcacagttcc
ggcagctttg agttgcgcct gaagtacttc 240 agcaacgatc acgggcggga
caacgagggt cgctgctgca gcggggagtc ggacggagcg 300 acgggcaagt
gcctgggcag ctgcaagacg cggtttcgcg tctgcctaaa gcactaccag 360
gccaccatcg acaccacctc ccagtgcacc tacggggacg tgatcacgcc cattctcggc
420 gagaactcgg tcaatctgac cgacgcccag cgcttccaga acaagggctt
cacgaatccc 480 atccagttcc ccttctcgtt ctcatggccg ggtaccttct
cgctgatcgt cgaggcctgg 540 catgatacga acaatagcgg caatgcgcga
accaacaagc tcctcatcca gcgactcttg 600 gtgcagcagg tactggaggt
gtcctccgaa tggaagacga acaagtcgga atcgcagtac 660 acgtcgctgg
agtacgattt ccgtgtcacc tgcgatctca actactacgg atccggctgt 720
gccaagttct gccggccccg cgacgattca tttggacact cgacttgctc ggagacgggc
780 gaaattatct gtttgaccgg atggcagggc gattactgtc acatacccaa
atgcgccaaa 840 ggctgtgaac atggacattg cgacaaacgc aatcaatgcg
tttgccaact gggctggaag 900 ggagccttgt gcaacgagtg cgttctggaa
ccgaactgca tccatggcac ctgcaacaaa 960 ccctggactt gcatctgcaa
cgagggttgg ggaggcttgt actgcaacca ggatctgaac 1020 tactgcacca
accacagacc ctgcaagaat ggcggaacct gcttcaacac cggcgaggga 1080
ttgtacacat gcaaatgcgc tccaggatac agtggtgatg attgcgaaaa tgagatctac
1140 tcctgcgatg ccgatgtcaa tccctgccag aatggtggta cctgcatcga
tgagccgcac 1200 acaaaaaccg gctacaagtg tcattgcgcc aacggctgga
gcggaaagat gtgcgaggag 1260 aaagtgctca cgtgttcgga caaaccctgt
catcagggaa tctgccgcaa cgttcgtcct 1320 ggcttgggaa gcaagggtca
gggctaccag tgcgaatgtc ccattggcta cagcggaccc 1380 aactgcgatc
tccagctgga caactgcagt ccgaatccat gcataaacgg tggaagctgt 1440
cagccgagcg gaaagtgtat ttgcccagcg ggattttcgg gaacgagatg cgagaccaac
1500 attgacgatt gtcttggcca ccagtgcgag aacggaggca cctgcataga
tatggtcaac 1560 caatatcgct gccaatgcgt tcccggtttc catggcaccc
actgtagtag caaagttgac 1620 ttgtgcctca tcagaccgtg tgccaatgga
ggaacctgct tgaatctcaa caacgattac 1680 cagtgcacct gtcgtgcggg
atttactggc aaggattgct ctgtggacat cgatgagtgc 1740 agcagtggac
cctgtcataa cggcggcact tgcatgaacc gcgtcaattc gttcgaatgc 1800
gtgtgtgcca atggtttcag gggcaagcag tgcgatgagg agtcctacga ttcggtgacc
1860 ttcgatgccc accaatatgg agcgaccaca caagcgagag ccgatggttt
gaccaatgcc 1920 caggtagtcc taattgctgt tttctccgtt gcgatgcctt
tggtggcggt tattgcggcg 1980 tgcgtggtct tctgcatgaa gcgcaagcgt
aagcgtgctc aggaaaagga cgacgcggag 2040 gccaggaagc agaacgaaca
gaatgcggtg gccacaatgc atcacaatgg cagtggggtg 2100 ggtgtagctt
tggcttcagc ctctctgggc ggcaaaactg gcagcaacag cggtctcacc 2160
ttcgatggcg gcaacccgaa tatcatcaaa aacacctggg acaagtcggt caacaacatt
2220 tgtgcctcag cagcagcagc ggcggcggcg gcagcagcgg cggacgagtg
tctcatgtac 2280 ggcggatatg tggcctcggt ggcggataac aacaatgcca
actcatactt ttgtgtggct 2340 ccgctacaaa gagccaagtc gcaaaagcaa
ctcaacaccg atcccacgct catgcaccgc 2400 ggttcgccgg caggcagctc
agccaaggga gcgtctggcg gaggaccggg agcggcggag 2460 ggcaagagga
tctctgtttt aggcgagggt tcctactgta gccagcgttg gccctcgttg 2520
gcggcggcgg gagtggccgg agcctgttca tcccagctaa tggctgcagc ttcggcagcg
2580 ggcagcggag cggggacggc gcaacagcag cgatccgtgg tctgcggcac
tccgcatatg 2640 taactccaaa aatccggaag ggctcctggt aaatccggag
aaatccgcat ggaggagctg 2700 acagcacata cacaaagaaa agactgggtt
gggttcaaaa tgtgagagag acgccaaaat 2760 gttgttgttg attgaagcag
tttagtcgtc acgaaaaatg aaaaatctgt aacaggcata 2820 actcgtaaac
tccctaaaaa atttgtatag taattagcaa agctgtgacc cagccgtttc 2880
gatcccgaat tc 2892 <210> SEQ ID NO 2 <211> LENGTH: 833
<212> TYPE: PRT <213> ORGANISM: Drosophila sp.
<400> SEQUENCE: 2 Met His Trp Ile Lys Cys Leu Leu Thr Ala Phe
Ile Cys Phe Thr Val 1 5 10 15 Ile Val Gln Val His Ser Ser Gly Ser
Phe Glu Leu Arg Leu Lys Tyr 20 25 30 Phe Ser Asn Asp His Gly Arg
Asp Asn Glu Gly Arg Cys Cys Ser Gly 35 40 45 Glu Ser Asp Gly Ala
Thr Gly Lys Cys Leu Gly Ser Cys Lys Thr Arg 50 55 60 Phe Arg Val
Cys Leu Lys His Tyr Gln Ala Thr Ile Asp Thr Thr Ser 65 70 75 80 Gln
Cys Thr Tyr Gly Asp Val Ile Thr Pro Ile Leu Gly Glu Asn Ser 85 90
95 Val Asn Leu Thr Asp Ala Gln Arg Phe Gln Asn Lys Gly Phe Thr Asn
100 105 110 Pro Ile Gln Phe Pro Phe Ser Phe Ser Trp Pro Gly Thr Phe
Ser Leu 115 120 125 Ile Val Glu Ala Trp His Asp Thr Asn Asn Ser Gly
Asn Ala Arg Thr 130 135 140 Asn Lys Leu Leu Ile Gln Arg Leu Leu Val
Gln Gln Val Leu Glu Val 145 150 155 160 Ser Ser Glu Trp Lys Thr Asn
Lys Ser Glu Ser Gln Tyr Thr Ser Leu 165 170 175 Glu Tyr Asp Phe Arg
Val Thr Cys Asp Leu Asn Tyr Tyr Gly Ser Gly 180 185 190 Cys Ala Lys
Phe Cys Arg Pro Arg Asp Asp Ser Phe Gly His Ser Thr 195 200 205 Cys
Ser Glu Thr Gly Glu Ile Ile Cys Leu Thr Gly Trp Gln Gly Asp 210 215
220 Tyr Cys His Ile Pro Lys Cys Ala Lys Gly Cys Glu His Gly His Cys
225 230 235 240 Asp Lys Arg Asn Gln Cys Val Cys Gln Leu Gly Trp Lys
Gly Ala Leu 245 250 255 Cys Asn Glu Cys Val Leu Glu Pro Asn Cys Ile
His Gly Thr Cys Asn 260 265 270 Lys Pro Trp Thr Cys Ile Cys Asn Glu
Gly Trp Gly Gly Leu Tyr Cys 275 280 285 Asn Gln Asp Leu Asn Tyr Cys
Thr Asn His Arg Pro Cys Lys Asn Gly 290 295 300 Gly Thr Cys Phe Asn
Thr Gly Glu Gly Leu Tyr Thr Cys Lys Cys Ala 305 310 315 320 Pro Gly
Tyr Ser Gly Asp Asp Cys Glu Asn Glu Ile Tyr Ser Cys Asp 325 330 335
Ala Asp Val Asn Pro Cys Gln Asn Gly Gly Thr Cys Ile Asp Glu Pro 340
345 350 His Thr Lys Thr Gly Tyr Lys Cys His Cys Ala Asn Gly Trp Ser
Gly 355 360 365 Lys Met Cys Glu Glu Lys Val Leu Thr Cys Ser Asp Lys
Pro Cys His 370 375 380 Gln Gly Ile Cys Arg Asn Val Arg Pro Gly Leu
Gly Ser Lys Gly Gln 385 390 395 400 Gly Tyr Gln Cys Glu Cys Pro Ile
Gly Tyr Ser Gly Pro Asn Cys Asp 405 410 415 Leu Gln Leu Asp Asn Cys
Ser Pro Asn Pro Cys Ile Asn Gly Gly Ser 420 425 430 Cys Gln Pro Ser
Gly Lys Cys Ile Cys Pro Ala Gly Phe Ser Gly Thr 435 440 445 Arg Cys
Glu Thr Asn Ile Asp Asp Cys Leu Gly His Gln Cys Glu Asn 450 455 460
Gly Gly Thr Cys Ile Asp Met Val Asn Gln Tyr Arg Cys Gln Cys Val 465
470 475 480 Pro Gly Phe His Gly Thr His Cys Ser Ser Lys Val Asp Leu
Cys Leu 485 490 495 Ile Arg Pro Cys Ala Asn Gly Gly Thr Cys Leu Asn
Leu Asn Asn Asp 500 505 510 Tyr Gln Cys Thr Cys Arg Ala Gly Phe Thr
Gly Lys Asp Cys Ser Val 515 520 525 Asp Ile Asp Glu Cys Ser Ser Gly
Pro Cys His Asn Gly Gly Thr Cys 530 535 540 Met Asn Arg Val Asn Ser
Phe Glu Cys Val Cys Ala Asn Gly Phe Arg 545 550 555 560 Gly Lys Gln
Cys Asp Glu Glu Ser Tyr Asp Ser Val Thr Phe Asp Ala 565 570 575 His
Gln Tyr Gly Ala Thr Thr Gln Ala Arg Ala Asp Gly Leu Thr Asn 580 585
590 Ala Gln Val Val Leu Ile Ala Val Phe Ser Val Ala Met Pro Leu Val
595 600 605 Ala Val Ile Ala Ala Cys Val Val Phe Cys Met Lys Arg Lys
Arg Lys 610 615 620 Arg Ala Gln Glu Lys Asp Asp Ala Glu Ala Arg Lys
Gln Asn Glu Gln 625 630 635 640 Asn Ala Val Ala Thr Met His His Asn
Gly Ser Gly Val Gly Val Ala 645 650 655 Leu Ala Ser Ala Ser Leu Gly
Gly Lys Thr Gly Ser Asn Ser Gly Leu 660 665 670 Thr Phe Asp Gly Gly
Asn Pro Asn Ile Ile Lys Asn Thr Trp Asp Lys 675 680 685
Ser Val Asn Asn Ile Cys Ala Ser Ala Ala Ala Ala Ala Ala Ala Ala 690
695 700 Ala Ala Ala Asp Glu Cys Leu Met Tyr Gly Gly Tyr Val Ala Ser
Val 705 710 715 720 Ala Asp Asn Asn Asn Ala Asn Ser Tyr Phe Cys Val
Ala Pro Leu Gln 725 730 735 Arg Ala Lys Ser Gln Lys Gln Leu Asn Thr
Asp Pro Thr Leu Met His 740 745 750 Arg Gly Ser Pro Ala Gly Ser Ser
Ala Lys Gly Ala Ser Gly Gly Gly 755 760 765 Pro Gly Ala Ala Glu Gly
Lys Arg Ile Ser Val Leu Gly Glu Gly Ser 770 775 780 Tyr Cys Ser Gln
Arg Trp Pro Ser Leu Ala Ala Ala Gly Val Ala Gly 785 790 795 800 Ala
Cys Ser Ser Gln Leu Met Ala Ala Ala Ser Ala Ala Gly Ser Gly 805 810
815 Ala Gly Thr Ala Gln Gln Gln Arg Ser Val Val Cys Gly Thr Pro His
820 825 830 Met <210> SEQ ID NO 3 <211> LENGTH: 6464
<212> TYPE: DNA <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 3 gaattcccct cccccctttt tccatgcagc tgatctaaaa
gggaataaaa ggctgcgcat 60 aatcataata ataaaagaag gggagcgcga
gagaaggaaa gaaagccggg aggtggaaga 120 ggagggggag cgtctcaaag
aagcgatcag aataataaaa ggaggccggg ctctttgcct 180 tctggaacgg
gccgctcttg aaagggcttt tgaaaagtgg tgttgttttc cagtcgtgca 240
tgctccaatc ggcggagtat attagagccg ggacgcggcc gcaggggcag cggcgacggc
300 agcaccggcg gcagcaccag cgcgaacagc agcggcggcg tcccgagtgc
ccgcggcggc 360 gcgcgcagcg atgcgttccc cacggacacg cggccggtcc
gggcgccccc taagcctcct 420 gctcgccctg ctctgtgccc tgcgagccaa
ggtgtgtggg gcctcgggtc agttcgagtt 480 ggagatcctg tccatgcaga
acgtgaacgg ggagctgcag aacgggaact gctgcggcgg 540 cgcccggaac
ccgggagacc gcaagtgcac ccgcgacgag tgtgacacat acttcaaagt 600
gtgcctcaag gagtatcagt cccgcgtcac ggccgggggg ccctgcagct tcggctcagg
660 gtccacgcct gtcatcgggg gcaacacctt caacctcaag gccagccgcg
gcaacgaccc 720 gaaccgcatc gtgctgcctt tcagtttcgc ctggccgagg
tcctatacgt tgcttgtgga 780 ggcgtgggat tccagtaatg acaccgttca
acctgacagt attattgaaa aggcttctca 840 ctcgggcatg atcaacccca
gccggcagtg gcagacgctg aagcagaaca cgggcgttgc 900 ccactttgag
tatcagatcc gcgtgacctg tgatgactac tactatggct ttggctgtaa 960
taagttctgc cgccccagag atgacttctt tggacactat gcctgtgacc agaatggcaa
1020 caaaacttgc atggaaggct ggatgggccc cgaatgtaac agagctattt
gccgacaagg 1080 ctgcagtcct aagcatgggt cttgcaaact cccaggtgac
tgcaggtgcc agtacggctg 1140 gcaaggcctg tactgtgata agtgcatccc
acacccggga tgcgtccacg gcatctgtaa 1200 tgagccctgg cagtgcctct
gtgagaccaa ctggggcggc cagctctgtg acaaagatct 1260 caattactgt
gggactcatc agccgtgtct caacggggga acttgtagca acacaggccc 1320
tgacaaatat cagtgttcct gccctgaggg gtattcagga cccaactgtg aaattgctga
1380 gcacgcctgc ctctctgatc cctgtcacaa cagaggcagc tgtaaggaga
cctccctggg 1440 ctttgagtgt gagtgttccc caggctggac cggccccaca
tgctctacaa acattgatga 1500 ctgttctcct aataactgtt cccacggggg
cacctgccag gacctggtta acggatttaa 1560 gtgtgtgtgc cccccacagt
ggactgggaa aacgtgccag ttagatgcaa atgaatgtga 1620 ggccaaacct
tgtgtaaacg ccaaatcctg taagaatctc attgccagct actactgcga 1680
ctgtcttccc ggctggatgg gtcagaattg tgacataaat attaatgact gccttggcca
1740 gtgtcagaat gacgcctcct gtcgggattt ggttaatggt tatcgctgta
tctgtccacc 1800 tggctatgca ggcgatcact gtgagagaga catcgatgaa
tgtgccagca acccctgttt 1860 gaatgggggt cactgtcaga atgaaatcaa
cagattccag tgtctgtgtc ccactggttt 1920 ctctggaaac ctctgtcagc
tggacatcga ttattgtgag cctaatccct gccagaacgg 1980 tgcccagtgc
tacaaccgtg ccagtgacta tttctgcaag tgccccgagg actatgaggg 2040
caagaactgc tcacacctga aagaccactg ccgcacgacc ccctgtgaag tgattgacag
2100 ctgcacagtg gccatggctt ccaacgacac acctgaaggg gtgcggtata
tttcctccaa 2160 cgtctgtggt cctcacggga agtgcaagag tcagtcggga
ggcaaattca cctgtgactg 2220 taacaaaggc ttcacgggaa catactgcca
tgaaaatatt aatgactgtg agagcaaccc 2280 ttgtagaaac ggtggcactt
gcatcgatgg tgtcaactcc tacaagtgca tctgtagtga 2340 cggctgggag
ggggcctact gtgaaaccaa tattaatgac tgcagccaga acccctgcca 2400
caatgggggc acgtgtcgcg acctggtcaa tgacttctac tgtgactgta aaaatgggtg
2460 gaaaggaaag acctgccact cacgtgacag tcagtgtgat gaggccacgt
gcaacaacgg 2520 tggcacctgc tatgatgagg gggatgcttt taagtgcatg
tgtcctggcg gctgggaagg 2580 aacaacctgt aacatagccc gaaacagtag
ctgcctgccc aacccctgcc ataatggggg 2640 cacatgtgtg gtcaacggcg
agtcctttac gtgcgtctgc aaggaaggct gggaggggcc 2700 catctgtgct
cagaatacca atgactgcag ccctcatccc tgttacaaca gcggcacctg 2760
tgtggatgga gacaactggt accggtgcga atgtgccccg ggttttgctg ggcccgactg
2820 cagaataaac atcaatgaat gccagtcttc accttgtgcc tttggagcga
cctgtgtgga 2880 tgagatcaat ggctaccggt gtgtctgccc tccagggcac
agtggtgcca agtgccagga 2940 agtttcaggg agaccttgca tcaccatggg
gagtgtgata ccagatgggg ccaaatggga 3000 tgatgactgt aatacctgcc
agtgcctgaa tggacggatc gcctgctcaa aggtctggtg 3060 tggccctcga
ccttgcctgc tccacaaagg gcacagcgag tgccccagcg ggcagagctg 3120
catccccatc ctggacgacc agtgcttcgt ccacccctgc actggtgtgg gcgagtgtcg
3180 gtcttccagt ctccagccgg tgaagacaaa gtgcacctct gactcctatt
accaggataa 3240 ctgtgcgaac atcacattta cctttaacaa ggagatgatg
tcaccaggtc ttactacgga 3300 gcacatttgc agtgaattga ggaatttgaa
tattttgaag aatgtttccg ctgaatattc 3360 aatctacatc gcttgcgagc
cttccccttc agcgaacaat gaaatacatg tggccatttc 3420 tgctgaagat
atacgggatg atgggaaccc gatcaaggaa atcactgaca aaataatcga 3480
tcttgttact aaacgtgatg gaaacagctc gctgattgct gccgttgaag aagtaagagt
3540 tcagaggcgg cctctgaaga acagaacaga tttccttgtt cccttgctga
gctctgtctt 3600 aactgtggct tggatctgtt gcttggtgac ggccttctac
tggtgcctgc ggaagcggcg 3660 gaagccgggc agccacacac actcagcctc
tgaggacaac accaccaaca acgtgcggga 3720 gcagctgaac cagatcaaaa
accccattga gaaacatggg gccaacacgg tccccatcaa 3780 ggattacgag
aacaagaact ccaaaatgtc taaaataagg acacacaatt ctgaagtaga 3840
agaggacgac atggacaaac accagcagaa agcccggttt gccaagcagc cggcgtacac
3900 gctggtagac agagaagaga agccccccaa cggcacgccg acaaaacacc
caaactggac 3960 aaacaaacag gacaacagag acttggaaag tgcccagagc
ttaaaccgaa tggagtacat 4020 cgtatagcag accgcgggca ctgccgccgc
taggtagagt ctgagggctt gtagttcttt 4080 aaactgtcgt gtcatactcg
agtctgaggc cgttgctgac ttagaatccc tgtgttaatt 4140 tagtttgaca
agctggctta cactggcaat ggtagttctg tggttggctg ggaaatcgag 4200
tggcgcatct cacagctatg caaaaagcta gtcaacagta cccctggttg tgtgtcccct
4260 tgcagccgac acggtctcgg atcaggctcc caggagctgc ccagccccct
ggtactttga 4320 gctcccactt ctgccagatg tctaatggtg atgcagtctt
agatcatagt tttatttata 4380 tttattgact cttgagttgt ttttgtatat
tggttttatg atgacgtaca agtagttctg 4440 tatttgaaag tgcctttgca
gctcagaacc acagcaacga tcacaaatga ctttattatt 4500 tatttttttt
aattgtattt ttgttgttgg gggaggggag actttgatgt cagcagttgc 4560
tggtaaaatg aagaatttaa agaaaaaatg tccaaaagta gaactttgta tagttatgta
4620 aataattctt ttttattaat cactgtgtat atttgattta ttaacttaat
aatcaagagc 4680 cttaaaacat cattcctttt tatttatatg tatgtgttta
gaattgaagg tttttgatag 4740 cattgtaagc gtatggcttt atttttttga
actcttctca ttacttgttg cctataagcc 4800 aaaaaggaaa gggtgttttg
aaaatagttt attttaaaac aataggatgg gctacacgta 4860 cataggtaaa
taatagcacc gtactggtta tgatgatgaa aataactgga aacttgaaag 4920
cttgtggtaa tggcagataa agatggttca cctgggaaat taaaacttga atggttgtac
4980 agaaaagcac agagtggaat gcacatcaat gacagtaagg gagttagttc
taggaacagc 5040 tcctgaacag taagattccc gcaatagtct ccgcctcgtt
cgtctatggt atgcatccca 5100 ttcattttct tcttctgatt attgtcatct
ttccctttgc caaatgggca gttattgttt 5160 cagggagaga agctgctcat
tggccaatca ttctggtgtg cagtgctcca tcggattcta 5220 catgtccaac
aaggcatgtc tggatgatgc aatgtctgtc tgacccccgg aattccgtgc 5280
agagacaaca ttctagacag atatacactt tttattatta acaaactttg gccacaacct
5340 ttgatgtata aattgccgga tttccccagt cctttcattg tggctttgga
caggagcagg 5400 ctcacttgtc tgcttcaggc tgcctttctc ttgggttgca
cctcagttct tacttattta 5460 tttattttga gtggagcata ggggcctctt
ccaaaatggg tagagctcag gggctttctt 5520 attgaaatgg tcacatgata
aaaacgggct gaaaaaggag agttccagga gaaaagccca 5580 gaaaaggccc
ctcctcagaa gacagccttt aagcctcttg cttactgaag gaagccccac 5640
cttctagcac tgaggccggg tctgatcttc cagaggagtt ggaggagtcc atgagaatgg
5700 ccaccattct tgcttgctgc tgctgatgtt gcagttttga gagaacagcg
ggatccttgt 5760 tgtcctctag agacttgagt ctgtcactga cattttttca
gttcctttgc tcatagacca 5820 tacgaggaat tagtgatgtg tcagttgaga
gttcacaatc tcattgttca tttaattcac 5880 tttaaagttg tcaatttctg
tgtgagtaac ctgtaaaaga cacctttcca gaagagtttt 5940 gccgtctgtt
tgaaaaaaaa atctttataa actttcctaa gtatctggat ttggattcct 6000
tatttggaga gaaaatgtac cctgtctcca ccaaaaatac aaaaattagc caggcttggt
6060 ggtgcacacc ggtaatccca gcaactctgg agactaaggc aggaagaatc
gcttgaccca 6120 ggagggtcga ggctacaatg agttgaaacc gcgccactgc
actccagcct gggcgacagt 6180 gcgaggccct gtctcaaaaa taaaataaaa
taaataaata aattagccag atactgtgtg 6240 cacgcctgca gtcccagcta
ttctggaagc tgaggtggga agatggttaa gcctgagagg 6300 acaaagctgc
agtgagtcat gtttgcatca ctgcactcca gcctgggtga cagagcaaga 6360
ccctgtctaa aaaacaaaaa caggccgggt gtggtggctc atgcctgcca tcccagtgct
6420
ttgggaggca gaggttggca taatcccagc gctctgggaa ttcc 6464 <210>
SEQ ID NO 4 <211> LENGTH: 1218 <212> TYPE: PRT
<213> ORGANISM: Homo sapiens <400> SEQUENCE: 4 Met Arg
Ser Pro Arg Thr Arg Gly Arg Ser Gly Arg Pro Leu Ser Leu 1 5 10 15
Leu Leu Ala Leu Leu Cys Ala Leu Arg Ala Lys Val Cys Gly Ala Ser 20
25 30 Gly Gln Phe Glu Leu Glu Ile Leu Ser Met Gln Asn Val Asn Gly
Glu 35 40 45 Leu Gln Asn Gly Asn Cys Cys Gly Gly Ala Arg Asn Pro
Gly Asp Arg 50 55 60 Lys Cys Thr Arg Asp Glu Cys Asp Thr Tyr Phe
Lys Val Cys Leu Lys 65 70 75 80 Glu Tyr Gln Ser Arg Val Thr Ala Gly
Gly Pro Cys Ser Phe Gly Ser 85 90 95 Gly Ser Thr Pro Val Ile Gly
Gly Asn Thr Phe Asn Leu Lys Ala Ser 100 105 110 Arg Gly Asn Asp Pro
Asn Arg Ile Val Leu Pro Phe Ser Phe Ala Trp 115 120 125 Pro Arg Ser
Tyr Thr Leu Leu Val Glu Ala Trp Asp Ser Ser Asn Asp 130 135 140 Thr
Val Gln Pro Asp Ser Ile Ile Glu Lys Ala Ser His Ser Gly Met 145 150
155 160 Ile Asn Pro Ser Arg Gln Trp Gln Thr Leu Lys Gln Asn Thr Gly
Val 165 170 175 Ala His Phe Glu Tyr Gln Ile Arg Val Thr Cys Asp Asp
Tyr Tyr Tyr 180 185 190 Gly Phe Gly Cys Asn Lys Phe Cys Arg Pro Arg
Asp Asp Phe Phe Gly 195 200 205 His Tyr Ala Cys Asp Gln Asn Gly Asn
Lys Thr Cys Met Glu Gly Trp 210 215 220 Met Gly Pro Glu Cys Asn Arg
Ala Ile Cys Arg Gln Gly Cys Ser Pro 225 230 235 240 Lys His Gly Ser
Cys Lys Leu Pro Gly Asp Cys Arg Cys Gln Tyr Gly 245 250 255 Trp Gln
Gly Leu Tyr Cys Asp Lys Cys Ile Pro His Pro Gly Cys Val 260 265 270
His Gly Ile Cys Asn Glu Pro Trp Gln Cys Leu Cys Glu Thr Asn Trp 275
280 285 Gly Gly Gln Leu Cys Asp Lys Asp Leu Asn Tyr Cys Gly Thr His
Gln 290 295 300 Pro Cys Leu Asn Gly Gly Thr Cys Ser Asn Thr Gly Pro
Asp Lys Tyr 305 310 315 320 Gln Cys Ser Cys Pro Glu Gly Tyr Ser Gly
Pro Asn Cys Glu Ile Ala 325 330 335 Glu His Ala Cys Leu Ser Asp Pro
Cys His Asn Arg Gly Ser Cys Lys 340 345 350 Glu Thr Ser Leu Gly Phe
Glu Cys Glu Cys Ser Pro Gly Trp Thr Gly 355 360 365 Pro Thr Cys Ser
Thr Asn Ile Asp Asp Cys Ser Pro Asn Asn Cys Ser 370 375 380 His Gly
Gly Thr Cys Gln Asp Leu Val Asn Gly Phe Lys Cys Val Cys 385 390 395
400 Pro Pro Gln Trp Thr Gly Lys Thr Cys Gln Leu Asp Ala Asn Glu Cys
405 410 415 Glu Ala Lys Pro Cys Val Asn Ala Lys Ser Cys Lys Asn Leu
Ile Ala 420 425 430 Ser Tyr Tyr Cys Asp Cys Leu Pro Gly Trp Met Gly
Gln Asn Cys Asp 435 440 445 Ile Asn Ile Asn Asp Cys Leu Gly Gln Cys
Gln Asn Asp Ala Ser Cys 450 455 460 Arg Asp Leu Val Asn Gly Tyr Arg
Cys Ile Cys Pro Pro Gly Tyr Ala 465 470 475 480 Gly Asp His Cys Glu
Arg Asp Ile Asp Glu Cys Ala Ser Asn Pro Cys 485 490 495 Leu Asn Gly
Gly His Cys Gln Asn Glu Ile Asn Arg Phe Gln Cys Leu 500 505 510 Cys
Pro Thr Gly Phe Ser Gly Asn Leu Cys Gln Leu Asp Ile Asp Tyr 515 520
525 Cys Glu Pro Asn Pro Cys Gln Asn Gly Ala Gln Cys Tyr Asn Arg Ala
530 535 540 Ser Asp Tyr Phe Cys Lys Cys Pro Glu Asp Tyr Glu Gly Lys
Asn Cys 545 550 555 560 Ser His Leu Lys Asp His Cys Arg Thr Thr Pro
Cys Glu Val Ile Asp 565 570 575 Ser Cys Thr Val Ala Met Ala Ser Asn
Asp Thr Pro Glu Gly Val Arg 580 585 590 Tyr Ile Ser Ser Asn Val Cys
Gly Pro His Gly Lys Cys Lys Ser Gln 595 600 605 Ser Gly Gly Lys Phe
Thr Cys Asp Cys Asn Lys Gly Phe Thr Gly Thr 610 615 620 Tyr Cys His
Glu Asn Ile Asn Asp Cys Glu Ser Asn Pro Cys Arg Asn 625 630 635 640
Gly Gly Thr Cys Ile Asp Gly Val Asn Ser Tyr Lys Cys Ile Cys Ser 645
650 655 Asp Gly Trp Glu Gly Ala Tyr Cys Glu Thr Asn Ile Asn Asp Cys
Ser 660 665 670 Gln Asn Pro Cys His Asn Gly Gly Thr Cys Arg Asp Leu
Val Asn Asp 675 680 685 Phe Tyr Cys Asp Cys Lys Asn Gly Trp Lys Gly
Lys Thr Cys His Ser 690 695 700 Arg Asp Ser Gln Cys Asp Glu Ala Thr
Cys Asn Asn Gly Gly Thr Cys 705 710 715 720 Tyr Asp Glu Gly Asp Ala
Phe Lys Cys Met Cys Pro Gly Gly Trp Glu 725 730 735 Gly Thr Thr Cys
Asn Ile Ala Arg Asn Ser Ser Cys Leu Pro Asn Pro 740 745 750 Cys His
Asn Gly Gly Thr Cys Val Val Asn Gly Glu Ser Phe Thr Cys 755 760 765
Val Cys Lys Glu Gly Trp Glu Gly Pro Ile Cys Ala Gln Asn Thr Asn 770
775 780 Asp Cys Ser Pro His Pro Cys Tyr Asn Ser Gly Thr Cys Val Asp
Gly 785 790 795 800 Asp Asn Trp Tyr Arg Cys Glu Cys Ala Pro Gly Phe
Ala Gly Pro Asp 805 810 815 Cys Arg Ile Asn Ile Asn Glu Cys Gln Ser
Ser Pro Cys Ala Phe Gly 820 825 830 Ala Thr Cys Val Asp Glu Ile Asn
Gly Tyr Arg Cys Val Cys Pro Pro 835 840 845 Gly His Ser Gly Ala Lys
Cys Gln Glu Val Ser Gly Arg Pro Cys Ile 850 855 860 Thr Met Gly Ser
Val Ile Pro Asp Gly Ala Lys Trp Asp Asp Asp Cys 865 870 875 880 Asn
Thr Cys Gln Cys Leu Asn Gly Arg Ile Ala Cys Ser Lys Val Trp 885 890
895 Cys Gly Pro Arg Pro Cys Leu Leu His Lys Gly His Ser Glu Cys Pro
900 905 910 Ser Gly Gln Ser Cys Ile Pro Ile Leu Asp Asp Gln Cys Phe
Val His 915 920 925 Pro Cys Thr Gly Val Gly Glu Cys Arg Ser Ser Ser
Leu Gln Pro Val 930 935 940 Lys Thr Lys Cys Thr Ser Asp Ser Tyr Tyr
Gln Asp Asn Cys Ala Asn 945 950 955 960 Ile Thr Phe Thr Phe Asn Lys
Glu Met Met Ser Pro Gly Leu Thr Thr 965 970 975 Glu His Ile Cys Ser
Glu Leu Arg Asn Leu Asn Ile Leu Lys Asn Val 980 985 990 Ser Ala Glu
Tyr Ser Ile Tyr Ile Ala Cys Glu Pro Ser Pro Ser Ala 995 1000 1005
Asn Asn Glu Ile His Val Ala Ile Ser Ala Glu Asp Ile Arg Asp 1010
1015 1020 Asp Gly Asn Pro Ile Lys Glu Ile Thr Asp Lys Ile Ile Asp
Leu 1025 1030 1035 Val Thr Lys Arg Asp Gly Asn Ser Ser Leu Ile Ala
Ala Val Glu 1040 1045 1050 Glu Val Arg Val Gln Arg Arg Pro Leu Lys
Asn Arg Thr Asp Phe 1055 1060 1065 Leu Val Pro Leu Leu Ser Ser Val
Leu Thr Val Ala Trp Ile Cys 1070 1075 1080 Cys Leu Val Thr Ala Phe
Tyr Trp Cys Leu Arg Lys Arg Arg Lys 1085 1090 1095 Pro Gly Ser His
Thr His Ser Ala Ser Glu Asp Asn Thr Thr Asn 1100 1105 1110 Asn Val
Arg Glu Gln Leu Asn Gln Ile Lys Asn Pro Ile Glu Lys 1115 1120 1125
His Gly Ala Asn Thr Val Pro Ile Lys Asp Tyr Glu Asn Lys Asn 1130
1135 1140 Ser Lys Met Ser Lys Ile Arg Thr His Asn Ser Glu Val Glu
Glu 1145 1150 1155 Asp Asp Met Asp Lys His Gln Gln Lys Ala Arg Phe
Ala Lys Gln 1160 1165 1170 Pro Ala Tyr Thr Leu Val Asp Arg Glu Glu
Lys Pro Pro Asn Gly 1175 1180 1185 Thr Pro Thr Lys His Pro Asn Trp
Thr Asn Lys Gln Asp Asn Arg 1190 1195 1200 Asp Leu Glu Ser Ala Gln
Ser Leu Asn Arg Met Glu Tyr Ile Val 1205 1210 1215 <210> SEQ
ID NO 5 <211> LENGTH: 4483 <212> TYPE: DNA <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 5 ggccggggcc
gggcgggcgg gtcgcggggg caatgcgggc gcagggccgg gggcgccttc 60
cccggcggct gctgctgctg ctggcgctct gggtgcaggc ggcgcggccc atgggctatt
120 tcgagctgca gctgagcgcg ctgcggaacg tgaacgggga gctgctgagc
ggcgcctgct 180 gtgacggcga cggccggaca acgcgcgcgg ggggctgcgg
ccacgacgag tgcgacaccg 240 ctcctttacc ctcatcgtgg aggcctggga
ctgggacaac gataccaccc cgaatgagga 300 gctgctgatc gagcgagtgt
cgcatgccgg catgatcaac ccggaggacc gctggaagag 360 cctgcacttc
agcggccacg tggcgcacct ggagctgcag atccgcgtgc gctgcgacga 420
gaactactac agcgccactt gcaacaagtt ctgccggccc cgcaatgact ttttcggcca
480 ctacacctgc gaccagtacg gcaacaaggc ctgcatggac ggctggatgg
gcaaggagtg 540 caaggaagct gtgtgtaaac aagggtgtaa tttgctccac
gggggatgca ccgtgcctgg 600 ggagtgcagg tgcagctacg gctggcaagg
gaggttctgc gatgagtgtg tcccctaccc 660 cggctgcgtg catggcagtt
gtgtggagcc ctggcagtgc aactgtgaga ccaactgggg 720 cggcctgctc
tgtgacaaag acctgaacta ctgtggcagc caccacccct gcaccaacgg 780
aggcacgtgc atcaacgccg agcctgacca gtaccgctgc acctgccctg acggctactc
840 gggcaggaac tgtgagaagg ctgagcacgc ctgcacctcc aacccgtgtg
ccaacggggg 900 ctcttgccat gaggtgccgt ccggcttcga atgccactgc
ccatcgggct ggagcgggcc 960 cacctgtgcc cttgacatcg atgagtgtgc
ttcgaacccg tgtgcggccg gtggcacctg 1020 tgtggaccag gtggacggct
ttgagtgcat ctgccccgag cagtgggtgg gggccacctg 1080 ccagctggac
gccaatgagt gtgaagggaa gccatgcctt aacgcttttt cttgcaaaaa 1140
cctgattggc ggctattact gtgattgcat cccgggctgg aagggcatca actgccatat
1200 caacgtcaac gactgtcgcg ggcagtgtca gcatgggggc acctgcaagg
acctggtgaa 1260 cgggtaccag tgtgtgtgcc cacggggctt cggaggccgg
cattgcgagc tggaacgaga 1320 caagtgtgcc agcagcccct gccacagcgg
cggcctctgc gaggacctgg ccgacggctt 1380 ccactgccac tgcccccagg
gcttctccgg gcctctctgt gaggtggatg tcgacctttg 1440 tgagccaagc
ccctgccgga acggcgctcg ctgctataac ctggagggtg actattactg 1500
cgcctgccct gatgactttg gtggcaagaa ctgctccgtg ccccgcgagc cgtgccctgg
1560 cggggcctgc agagtgatcg atggctgcgg gtcagacgcg gggcctggga
tgcctggcac 1620 agcagcctcc ggcgtgtgtg gcccccatgg acgctgcgtc
agccagccag ggggcaactt 1680 ttcctgcatc tgtgacagtg gctttactgg
cacctactgc catgagaaca ttgacgactg 1740 cctgggccag ccctgccgca
atgggggcac atgcatcgat gaggtggacg ccttccgctg 1800 cttctgcccc
agcggttggg agggcgagct ctgcgacacc aatcccaacg actgccttcc 1860
cgatccctgc cacagccgcg gccgctgcta cgacctggtc aatgacttct actgtgcgtg
1920 cgacgacggc tggaagggca agacctgcca ctcacgcgag ttccagtgcg
atgcctacac 1980 ctgcagcaac ggtggcacct gctacgacag cggcgacacc
ttccgctgcg cctgcccccc 2040 cggctggaag ggcagcacct gcgccgtcgc
caagaacagc agctgcctgc ccaacccctg 2100 tgtgaatggt ggcacctgcg
tgggcagcgg ggcctccttc tcctgcatct gccgggacgg 2160 ctgggagggt
cgtacttgca ctcacaatac caacgactgc aaccctctgc cttgctacaa 2220
tggtggcatc tgtgttgacg gcgtcaactg gttccgctgc gagtgtgcac ctggcttcgc
2280 ggggcctgac tgccgcatca acatcgacga gtgccagtcc tcgccctgtg
cctacggggc 2340 cacgtgtgtg gatgagatca acgggtatcg ctgtagctgc
ccacccggcc gagccggccc 2400 ccggtgccag gaagtgatcg ggttcgggag
atcctgctgg tcccggggca ctccgttccc 2460 acacggaagc tcctgggtgg
aagactgcaa cagctgccgc tgcctggatg gccgccgtga 2520 ctgcagcaag
gtgtggtgcg gatggaagcc ttgtctgctg gccggccagc ccgaggccct 2580
gagcgcccag tgcccactgg ggcaaaggtg cctggagaag gccccaggcc agtgtctgcg
2640 accaccctgt gaggcctggg gggagtgcgg cgcagaagag ccaccgagca
ccccctgcct 2700 gccacgctcc ggccacctgg acaataactg tgcccgcctc
accttgcatt tcaaccgtga 2760 ccacgtgccc cagggcacca cggtgggcgc
catttgctcc gggatccgct ccctgccagc 2820 cacaagggct gtggcacggg
accgcctgct ggtgttgctt tgcgaccggg cgtcctcggg 2880 ggccagtgct
gtggaggtgg ccgtgtcctt cagccctgcc agggacctgc ctgacagcag 2940
cctgatccag ggcgcggccc acgccatcgt ggccgccatc acccagcggg ggaacagctc
3000 actgctcctg gctgtcaccg aggtcaaggt ggagacggtt gttacgggcg
gctcttccac 3060 aggtctgctg gtgcctgtgc tgtgtggtgc cttcagcgtg
ctgtggctgg cgtgcgtggt 3120 cctgtgcgtg tggtggacac gcaagcgcag
gaaagagcgg gagaggagcc ggctgccgcg 3180 ggaggagagc gccaacaacc
agtgggcccc gctcaacccc atccgcaacc ccattgagcg 3240 gccggggggg
cacaaggacg tgctctacca gtgcaagaac ttcactccac cgccgcgcag 3300
gcgctgcccg ggccggccgg ccacgcggcc gtcagggagg atgaggagga cgaggatctt
3360 ggccgcggtg aggaggactc cctggaggcg gagaagttcc tctcacacaa
attcaccaaa 3420 gatcctggcc gctcgccggg gaggccggcc cactgggcct
caggccccaa agtggacaac 3480 cgcgcggtca ggagcatcaa tgaggcccgc
tacgtcggca agggaagtag ggcggctgca 3540 gctgggccgg gacccagggc
cctcggtggg agccatgccg tctgccggac ccggaggccg 3600 aggccatgtg
catagtttct ttattttgtg taaaaaaacc accaaaaaca aaaaccaaat 3660
gtttattttc tacgtttctt taaccttgta taaattattc agtaactgtc aggctgaaaa
3720 caatggagta ttctcggata gttgctattt ttgtaaagta gccgtgcgtg
gcactcgctg 3780 tatgaaagga gagagcaaag ggtgtctgcg tcgtcaccaa
atcgtcgcgt ttgttaccag 3840 aggttgtgca ctgtttacag aatcttcctt
ttattcctca ctcgggtttc tctgtgctcc 3900 aggccaaagt gccggtgaga
cccatggctg tgttggtgtg gcccatggct gttggtggga 3960 cccgtggctg
atggtgtggc ctgtggctgt cggtgggact cgtggctgtc aatgggacct 4020
gtggctgtcg gtgggaccta cggtggtcgg tgggaccctg gttattgatg tggccctggc
4080 tgccggcacg gcccgtggct gttgacgcac ctgtggttgt tagtggggcc
tgaggtcatc 4140 ggcgtggccc aaggccggca ggtcaacctc gcgcttgctg
gccagtccac cctgcctgcc 4200 gtctgtgctt cctcctgccc agaacgcccg
ctccagcgat ctctccactg tgctttcaga 4260 agtgcccttc ctgctgcgca
gttctcccat cctgggacgg cggcagtatt gaagctcgtg 4320 acaagtgcct
tcacacagac ccctcgcaac tgtccacgcg tgccgtggca ccaggcgctg 4380
cccacctgcc ggccccggcc gcccctcctc gtgaaagtgc atttttgtaa atgtgtacat
4440 attaaaggaa gcactctgta taaaaaaaaa aaaccggaat tcc 4483
<210> SEQ ID NO 6 <211> LENGTH: 1257 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 6 Met
Ile Asn Pro Glu Asp Arg Trp Lys Ser Leu His Phe Ser Gly His 1 5 10
15 Val Ala His Leu Glu Leu Gln Ile Arg Val Arg Cys Asp Glu Asn Tyr
20 25 30 Tyr Ser Ala Thr Cys Asn Lys Phe Cys Arg Pro Arg Asn Asp
Phe Phe 35 40 45 Gly His Tyr Thr Cys Asp Gln Tyr Gly Asn Lys Ala
Cys Met Asp Gly 50 55 60 Trp Met Gly Lys Glu Cys Lys Glu Ala Val
Cys Lys Gln Gly Cys Asn 65 70 75 80 Leu Leu His Gly Gly Cys Thr Val
Pro Gly Glu Cys Arg Cys Ser Tyr 85 90 95 Gly Trp Gln Gly Arg Phe
Cys Asp Glu Cys Val Pro Tyr Pro Gly Cys 100 105 110 Val His Gly Ser
Cys Val Glu Pro Trp Gln Cys Asn Cys Glu Thr Asn 115 120 125 Trp Gly
Gly Leu Leu Cys Asp Lys Asp Leu Asn Tyr Cys Gly Ser His 130 135 140
His Pro Cys Thr Asn Gly Gly Thr Cys Ile Asn Ala Glu Pro Asp Gln 145
150 155 160 Tyr Arg Cys Thr Cys Pro Asp Gly Tyr Ser Gly Arg Asn Cys
Glu Lys 165 170 175 Ala Glu His Ala Cys Thr Ser Asn Pro Cys Ala Asn
Gly Gly Ser Cys 180 185 190 His Glu Val Pro Ser Gly Phe Glu Cys His
Cys Pro Ser Gly Trp Ser 195 200 205 Gly Pro Thr Cys Ala Leu Asp Ile
Asp Glu Cys Ala Ser Asn Pro Cys 210 215 220 Ala Ala Gly Gly Thr Cys
Val Asp Gln Val Asp Gly Phe Glu Cys Ile 225 230 235 240 Cys Pro Glu
Gln Trp Val Gly Ala Thr Cys Gln Leu Asp Ala Asn Glu 245 250 255 Cys
Glu Gly Lys Pro Cys Leu Asn Ala Phe Ser Cys Lys Asn Leu Ile 260 265
270 Gly Gly Tyr Tyr Cys Asp Cys Ile Pro Gly Trp Lys Gly Ile Asn Cys
275 280 285 His Ile Asn Val Asn Asp Cys Arg Gly Gln Cys Gln His Gly
Gly Thr 290 295 300 Cys Lys Asp Leu Val Asn Gly Tyr Gln Cys Val Cys
Pro Arg Gly Phe 305 310 315 320 Gly Gly Arg His Cys Glu Leu Glu Arg
Asp Lys Cys Ala Ser Ser Pro 325 330 335 Cys His Ser Gly Gly Leu Cys
Glu Asp Leu Ala Asp Gly Phe His Cys 340 345 350 His Cys Pro Gln Gly
Phe Ser Gly Pro Leu Cys Glu Val Asp Val Asp 355 360 365 Leu Cys Glu
Pro Ser Pro Cys Arg Asn Gly Ala Arg Cys Tyr Asn Leu 370 375 380 Glu
Gly Asp Tyr Tyr Cys Ala Cys Pro Asp Asp Phe Gly Gly Lys Asn 385 390
395 400 Cys Ser Val Pro Arg Glu Pro Cys Pro Gly Gly Ala Cys Arg Val
Ile 405 410 415 Asp Gly Cys Gly Ser Asp Ala Gly Pro Gly Met Pro Gly
Thr Ala Ala 420 425 430 Ser Gly Val Cys Gly Pro His Gly Arg Cys Val
Ser Gln Pro Gly Gly 435 440 445 Asn Phe Ser Cys Ile Cys Asp Ser Gly
Phe Thr Gly Thr Tyr Cys His 450 455 460 Glu Asn Ile Asp Asp Cys Leu
Gly Gln Pro Cys Arg Asn Gly Gly Thr 465 470 475 480 Cys Ile Asp Glu
Val Asp Ala Phe Arg Cys Phe Cys Pro Ser Gly Trp 485 490 495 Glu Gly
Glu Leu Cys Asp Thr Asn Pro Asn Asp Cys Leu Pro Asp Pro 500 505
510
Cys His Ser Arg Gly Arg Cys Tyr Asp Leu Val Asn Asp Phe Tyr Cys 515
520 525 Ala Cys Asp Asp Gly Trp Lys Gly Lys Thr Cys His Ser Arg Glu
Phe 530 535 540 Gln Cys Asp Ala Tyr Thr Cys Ser Asn Gly Gly Thr Cys
Tyr Asp Ser 545 550 555 560 Gly Asp Thr Phe Arg Cys Ala Cys Pro Pro
Gly Trp Lys Gly Ser Thr 565 570 575 Cys Ala Val Ala Lys Asn Ser Ser
Cys Leu Pro Asn Pro Cys Val Asn 580 585 590 Gly Gly Thr Cys Val Gly
Ser Gly Ala Ser Phe Ser Cys Ile Cys Arg 595 600 605 Asp Gly Trp Glu
Gly Arg Thr Cys Thr His Asn Thr Asn Asp Cys Asn 610 615 620 Pro Leu
Pro Cys Tyr Asn Gly Gly Ile Cys Val Asp Gly Val Asn Trp 625 630 635
640 Phe Arg Cys Glu Cys Ala Pro Gly Phe Ala Gly Pro Asp Cys Arg Ile
645 650 655 Asn Ile Asp Glu Cys Gln Ser Ser Pro Cys Ala Tyr Gly Ala
Thr Cys 660 665 670 Val Asp Glu Ile Asn Gly Tyr Arg Cys Ser Cys Pro
Pro Gly Arg Ala 675 680 685 Gly Pro Arg Cys Gln Glu Val Ile Gly Phe
Gly Arg Ser Cys Trp Ser 690 695 700 Arg Gly Thr Pro Phe Pro His Gly
Ser Ser Trp Val Glu Asp Cys Asn 705 710 715 720 Ser Cys Arg Cys Leu
Asp Gly Arg Arg Asp Cys Ser Lys Val Trp Cys 725 730 735 Gly Trp Lys
Pro Cys Leu Leu Ala Gly Gln Pro Glu Ala Leu Ser Ala 740 745 750 Gln
Cys Pro Leu Gly Gln Arg Cys Leu Glu Lys Ala Pro Gly Gln Cys 755 760
765 Leu Arg Pro Pro Cys Glu Ala Trp Gly Glu Cys Gly Ala Glu Glu Pro
770 775 780 Pro Ser Thr Pro Cys Leu Pro Arg Ser Gly His Leu Asp Asn
Asn Cys 785 790 795 800 Ala Arg Leu Thr Leu His Phe Asn Arg Asp His
Val Pro Gln Gly Thr 805 810 815 Thr Val Gly Ala Ile Cys Ser Gly Ile
Arg Ser Leu Pro Ala Thr Arg 820 825 830 Ala Val Ala Arg Asp Arg Leu
Leu Val Leu Leu Cys Asp Arg Ala Ser 835 840 845 Ser Gly Ala Ser Ala
Val Glu Val Ala Val Ser Phe Ser Pro Ala Arg 850 855 860 Asp Leu Pro
Asp Ser Ser Leu Ile Gln Gly Ala Ala His Ala Ile Val 865 870 875 880
Ala Ala Ile Thr Gln Arg Gly Asn Ser Ser Leu Leu Leu Ala Val Thr 885
890 895 Glu Val Lys Val Glu Thr Val Val Thr Gly Gly Ser Ser Thr Gly
Leu 900 905 910 Leu Val Pro Val Leu Cys Gly Ala Phe Ser Val Leu Trp
Leu Ala Cys 915 920 925 Val Val Leu Cys Val Trp Trp Thr Arg Lys Arg
Arg Lys Glu Arg Glu 930 935 940 Arg Ser Arg Leu Pro Arg Glu Glu Ser
Ala Asn Asn Gln Trp Ala Pro 945 950 955 960 Leu Asn Pro Ile Arg Asn
Pro Ile Glu Arg Pro Gly Gly His Lys Asp 965 970 975 Val Leu Tyr Gln
Cys Lys Asn Phe Thr Pro Pro Pro Arg Arg Arg Cys 980 985 990 Pro Gly
Arg Pro Ala Thr Arg Pro Ser Gly Arg Met Arg Arg Thr Arg 995 1000
1005 Ile Leu Ala Ala Val Arg Arg Thr Pro Trp Arg Arg Arg Ser Ser
1010 1015 1020 Ser His Thr Asn Ser Pro Lys Ile Leu Ala Ala Arg Arg
Gly Gly 1025 1030 1035 Arg Pro Thr Gly Pro Gln Ala Pro Lys Trp Thr
Thr Ala Arg Ser 1040 1045 1050 Gly Ala Ser Met Arg Pro Ala Thr Ser
Ala Arg Glu Val Gly Arg 1055 1060 1065 Leu Gln Leu Gly Arg Asp Pro
Gly Pro Ser Val Gly Ala Met Pro 1070 1075 1080 Ser Ala Gly Pro Gly
Gly Arg Gly His Val His Ser Phe Phe Ile 1085 1090 1095 Leu Cys Lys
Lys Thr Thr Lys Asn Lys Asn Gln Met Phe Ile Phe 1100 1105 1110 Tyr
Val Ser Leu Thr Leu Tyr Lys Leu Phe Ser Asn Cys Gln Ala 1115 1120
1125 Glu Asn Asn Gly Val Phe Ser Asp Ser Cys Tyr Phe Cys Lys Val
1130 1135 1140 Ala Val Arg Gly Thr Arg Cys Met Lys Gly Glu Ser Lys
Gly Cys 1145 1150 1155 Leu Arg Arg His Gln Ile Val Ala Phe Val Thr
Arg Gly Cys Ala 1160 1165 1170 Leu Phe Thr Glu Ser Ser Phe Tyr Ser
Ser Leu Gly Phe Leu Cys 1175 1180 1185 Ala Pro Gly Gln Ser Ala Gly
Glu Thr His Gly Cys Val Gly Val 1190 1195 1200 Ala His Gly Cys Trp
Trp Asp Pro Trp Leu Met Val Trp Pro Val 1205 1210 1215 Ala Val Gly
Gly Thr Arg Gly Cys Gln Trp Asp Leu Trp Leu Ser 1220 1225 1230 Val
Gly Pro Thr Val Val Gly Gly Thr Leu Val Ile Asp Val Ala 1235 1240
1245 Leu Ala Ala Gly Thr Ala Arg Gly Cys 1250 1255 <210> SEQ
ID NO 7 <211> LENGTH: 3582 <212> TYPE: DNA <213>
ORGANISM: Gallus sp. <400> SEQUENCE: 7 caggtggcgt cagcatcggg
acagttcgag ctggagatct tatccgtgca gaatgtgaac 60 ggcgtgctgc
agaacgggaa ctgctgcgac ggcactcgaa accccggaga taaaaagtgc 120
accagagatg agtgtgacac ctactttaaa gtttgcctga aggagtacca gtcgcgggtc
180 actgctggcg gcccttgcag cttcggatcc aaatccaccc ctgtcatcgg
cgggaatacc 240 ttcaatttaa agtacagccg gaataatgaa aagaaccgga
ttgttatccc tttcacgttc 300 gcctggccga gatcctacac gttgcttgtt
gaggcatggg attacaatga taactctact 360 aatcccgatc gcataattga
gaaggcatcc cactctggca tgatcaatcc aagccgtcag 420 tggcagacgt
tgaaacataa cacaggagct gcccactttg agtatcaaat ccgtgtgact 480
tgcgcagaac attactatgg ctttggatgc aacaagtttt gtcgaccgag agatgacttc
540 ttcactcacc atacctgtga ccagaatggc aacaaaacct gcttggaagg
ctggacggga 600 ccagaatgca acaaagctat ttgtcgtcag ggatgtagcc
ccaagcatgg ttcttgcaca 660 gttccaggag agtgcaggtg tcagtatgga
tggcaaggcc agtactgtga taagtgcatt 720 ccacacccgg gatgtgtcca
tggcacttgc attgaaccat ggcagtgcct ctgtgaaacc 780 aactggggtg
gtcagctctg tgacaaagac ctgaactact gtggaaccca cccaccctgt 840
ttgaatggtg gtacctgcag caacactggc cccgataaat accagtgttc ctgccctgag
900 ggttactcag gacagaactg tgaaatagcg gagcatgcgt gcctctctga
tccgtgccac 960 aacggaggaa gctgcctaga aacgtctaca ggatttgaat
gtgtgtgtgc acctggctgg 1020 gctggaccaa cttgcactga taatattgat
gattgttctc caaatccctg tggtcatgga 1080 ggaacttgcc aagatctagt
tgatggattt aagtgtattt gcccacctca gtggactggc 1140 aaaacatgcc
agctagatgc gaatgaatgt gagggcaaac cctgtgtcaa tgccaactcc 1200
tgcaggaact tgattggcag ctactattgt gactgcatta ctggctggtc tggccacaac
1260 tgtgatataa atattaatga ttgtcgtgga caatgtcaga atggaggatc
ctgtcgggac 1320 ttggttaatg gttatcggtg catctgttca cctggctatg
caggagatca ctgtgagaaa 1380 gacatcaatg aatgtgcaag taacccttgc
atgaatgggg gtcactgcca ggatgaaatc 1440 aatggattcc aatgtctgtg
tcctgctggt ttctcaggaa acctctgtca gctggatata 1500 gactactgtg
agccaaaccc ttgccagaac ggtgcccagt gcttcaatct tgctatggac 1560
tatttctgta actgccctga agattacgaa ggcaagaact gctcccacct gaaagatcac
1620 tgccgcacaa ctccttgtga agtaatcgac agctgtacag tggcagtggc
ttctaacagc 1680 acaccagaag gagttcgtta catttcttca aatgtctgtg
gtcctcatgg aaaatgcaag 1740 agccaagcag gtggaaaatt cacctgtgaa
tgcaacaaag gattcactgg cacctactgt 1800 catgagaata tcaatgactg
tgagagcaac ccctgtaaaa atggtggcac ttgtattgac 1860 ggtgtaaact
cctacaaatg tatttgtagt gatggatggg aaggaacata ttgtgaaaca 1920
aatattaatg actgcagtaa aaacccctgc cacaatggag gaacttgccg agacttggtc
1980 aatgacttct tctgtgaatg taaaaatggg tggaaaggaa aaacttgcca
ctctcgtgac 2040 agccagtgtg atgaggcaac atgcaataat ggaggaacat
gttatgatga gggggacact 2100 ttcaagtgca tgtgtcctgc aggatgggaa
ggagccactt gtaatatagc aaggaacagc 2160 agctgcctgc caaacccctg
tcacaatggt ggtacctgtg tagttagtgg ggattctttc 2220 acttgtgtct
gcaaggaggg ctgggaagga ccgacatgta ctcagaacac aaatgactgc 2280
agtcctcatc cttgttacaa cagtggtact tgtgtggatg gagacaactg gtaccgctgt
2340 gagtgcgctc ccggcttcgc aggtcccgac tgtaggatca acatcaatga
atgtcagtct 2400 tcaccctgtg cctttggggc tacttgtgtg gatgaaatta
atgggtaccg ttgcatttgt 2460 ccaccgggtc gcagtggtcc aggatgccag
gaagttacag ggaggccttg ctttaccagt 2520 attcgagtaa tgccagacgg
tgctaagtgg gatgatgact gtaatacttg tcagtgtttg 2580 aatggaaaag
tcacctgttc taaggtttgg tgtggtcctc gaccttgtat aatacatgcc 2640
aaaggtcata atgaatgccc agctggacac gcttgtgttc ctgttaaaga agaccattgt
2700 ttcactcatc cttgtgctgc agtgggtgaa tgctggcctt ctaatcagca
gcctgtgaag 2760 accaaatgca attctgattc ttattaccaa gataattgtg
ccaacatcac cttcaccttt 2820 aataaggaaa tgatggcacc aggccttacc
acggagcaca tttgcagtga attgaggaat 2880 ctgaatatcc tgaagaatgt
ttctgctgaa tattccatct atattacctg tgagccttca 2940
cacttggcaa ataatgaaat acatgttgct atttctgctg aagatatagg agaagatgaa
3000 aacccaatca aggaaatcac agataagatt attgaccttg tcagtaagcg
tgatggaaac 3060 aacacactaa ttgctgcagt cgcagaagtc agagtacaaa
ggcgaccagt taagaacaaa 3120 acagatttct tggtgccatt actgagctca
gtcttaacag tagcctggat ctgctgtctg 3180 gtaactgttt tctattggtg
cattcaaaag cgcagaaagc agagcagcca tactcacaca 3240 gcatctgatg
acaacaccac caacaacgta agggagcagc tgaatcagat taaaaacccc 3300
atagagaaac acggagcaaa tactgttcca attaaagact atgaaaacaa aaactctaaa
3360 atcgccaaaa taaggacgca caattcagaa gtggaggaag atgacatgga
caaacaccag 3420 caaaaggccc ggtttgccaa gcagccagcg tacactttgg
tagacagaga tgaaaagcca 3480 cccaacagca cacccacaaa acacccaaac
tggacaaata aacaggacaa cagagacttg 3540 gaaagtgcac aaagtttaaa
tagaatggag tacattgtat ag 3582 <210> SEQ ID NO 8 <211>
LENGTH: 1193 <212> TYPE: PRT <213> ORGANISM: Gallus sp.
<400> SEQUENCE: 8 Gln Val Ala Ser Ala Ser Gly Gln Phe Glu Leu
Glu Ile Leu Ser Val 1 5 10 15 Gln Asn Val Asn Gly Val Leu Gln Asn
Gly Asn Cys Cys Asp Gly Thr 20 25 30 Arg Asn Pro Gly Asp Lys Lys
Cys Thr Arg Asp Glu Cys Asp Thr Tyr 35 40 45 Phe Lys Val Cys Leu
Lys Glu Tyr Gln Ser Arg Val Thr Ala Gly Gly 50 55 60 Pro Cys Ser
Phe Gly Ser Lys Ser Thr Pro Val Ile Gly Gly Asn Thr 65 70 75 80 Phe
Asn Leu Lys Tyr Ser Arg Asn Asn Glu Lys Asn Arg Ile Val Ile 85 90
95 Pro Phe Thr Phe Ala Trp Pro Arg Ser Tyr Thr Leu Leu Val Glu Ala
100 105 110 Trp Asp Tyr Asn Asp Asn Ser Thr Asn Pro Asp Arg Ile Ile
Glu Lys 115 120 125 Ala Ser His Ser Gly Met Ile Asn Pro Ser Arg Gln
Trp Gln Thr Leu 130 135 140 Lys His Asn Thr Gly Ala Ala His Phe Glu
Tyr Gln Ile Arg Val Thr 145 150 155 160 Cys Ala Glu His Tyr Tyr Gly
Phe Gly Cys Asn Lys Phe Cys Arg Pro 165 170 175 Arg Asp Asp Phe Phe
Thr His His Thr Cys Asp Gln Asn Gly Asn Lys 180 185 190 Thr Cys Leu
Glu Gly Trp Thr Gly Pro Glu Cys Asn Lys Ala Ile Cys 195 200 205 Arg
Gln Gly Cys Ser Pro Lys His Gly Ser Cys Thr Val Pro Gly Glu 210 215
220 Cys Arg Cys Gln Tyr Gly Trp Gln Gly Gln Tyr Cys Asp Lys Cys Ile
225 230 235 240 Pro His Pro Gly Cys Val His Gly Thr Cys Ile Glu Pro
Trp Gln Cys 245 250 255 Leu Cys Glu Thr Asn Trp Gly Gly Gln Leu Cys
Asp Lys Asp Leu Asn 260 265 270 Tyr Cys Gly Thr His Pro Pro Cys Leu
Asn Gly Gly Thr Cys Ser Asn 275 280 285 Thr Gly Pro Asp Lys Tyr Gln
Cys Ser Cys Pro Glu Gly Tyr Ser Gly 290 295 300 Gln Asn Cys Glu Ile
Ala Glu His Ala Cys Leu Ser Asp Pro Cys His 305 310 315 320 Asn Gly
Gly Ser Cys Leu Glu Thr Ser Thr Gly Phe Glu Cys Val Cys 325 330 335
Ala Pro Gly Trp Ala Gly Pro Thr Cys Thr Asp Asn Ile Asp Asp Cys 340
345 350 Ser Pro Asn Pro Cys Gly His Gly Gly Thr Cys Gln Asp Leu Val
Asp 355 360 365 Gly Phe Lys Cys Ile Cys Pro Pro Gln Trp Thr Gly Lys
Thr Cys Gln 370 375 380 Leu Asp Ala Asn Glu Cys Glu Gly Lys Pro Cys
Val Asn Ala Asn Ser 385 390 395 400 Cys Arg Asn Leu Ile Gly Ser Tyr
Tyr Cys Asp Cys Ile Thr Gly Trp 405 410 415 Ser Gly His Asn Cys Asp
Ile Asn Ile Asn Asp Cys Arg Gly Gln Cys 420 425 430 Gln Asn Gly Gly
Ser Cys Arg Asp Leu Val Asn Gly Tyr Arg Cys Ile 435 440 445 Cys Ser
Pro Gly Tyr Ala Gly Asp His Cys Glu Lys Asp Ile Asn Glu 450 455 460
Cys Ala Ser Asn Pro Cys Met Asn Gly Gly His Cys Gln Asp Glu Ile 465
470 475 480 Asn Gly Phe Gln Cys Leu Cys Pro Ala Gly Phe Ser Gly Asn
Leu Cys 485 490 495 Gln Leu Asp Ile Asp Tyr Cys Glu Pro Asn Pro Cys
Gln Asn Gly Ala 500 505 510 Gln Cys Phe Asn Leu Ala Met Asp Tyr Phe
Cys Asn Cys Pro Glu Asp 515 520 525 Tyr Glu Gly Lys Asn Cys Ser His
Leu Lys Asp His Cys Arg Thr Thr 530 535 540 Pro Cys Glu Val Ile Asp
Ser Cys Thr Val Ala Val Ala Ser Asn Ser 545 550 555 560 Thr Pro Glu
Gly Val Arg Tyr Ile Ser Ser Asn Val Cys Gly Pro His 565 570 575 Gly
Lys Cys Lys Ser Gln Ala Gly Gly Lys Phe Thr Cys Glu Cys Asn 580 585
590 Lys Gly Phe Thr Gly Thr Tyr Cys His Glu Asn Ile Asn Asp Cys Glu
595 600 605 Ser Asn Pro Cys Lys Asn Gly Gly Thr Cys Ile Asp Gly Val
Asn Ser 610 615 620 Tyr Lys Cys Ile Cys Ser Asp Gly Trp Glu Gly Thr
Tyr Cys Glu Thr 625 630 635 640 Asn Ile Asn Asp Cys Ser Lys Asn Pro
Cys His Asn Gly Gly Thr Cys 645 650 655 Arg Asp Leu Val Asn Asp Phe
Phe Cys Glu Cys Lys Asn Gly Trp Lys 660 665 670 Gly Lys Thr Cys His
Ser Arg Asp Ser Gln Cys Asp Glu Ala Thr Cys 675 680 685 Asn Asn Gly
Gly Thr Cys Tyr Asp Glu Gly Asp Thr Phe Lys Cys Met 690 695 700 Cys
Pro Ala Gly Trp Glu Gly Ala Thr Cys Asn Ile Ala Arg Asn Ser 705 710
715 720 Ser Cys Leu Pro Asn Pro Cys His Asn Gly Gly Thr Cys Val Val
Ser 725 730 735 Gly Asp Ser Phe Thr Cys Val Cys Lys Glu Gly Trp Glu
Gly Pro Thr 740 745 750 Cys Thr Gln Asn Thr Asn Asp Cys Ser Pro His
Pro Cys Tyr Asn Ser 755 760 765 Gly Thr Cys Val Asp Gly Asp Asn Trp
Tyr Arg Cys Glu Cys Ala Pro 770 775 780 Gly Phe Ala Gly Pro Asp Cys
Arg Ile Asn Ile Asn Glu Cys Gln Ser 785 790 795 800 Ser Pro Cys Ala
Phe Gly Ala Thr Cys Val Asp Glu Ile Asn Gly Tyr 805 810 815 Arg Cys
Ile Cys Pro Pro Gly Arg Ser Gly Pro Gly Cys Gln Glu Val 820 825 830
Thr Gly Arg Pro Cys Phe Thr Ser Ile Arg Val Met Pro Asp Gly Ala 835
840 845 Lys Trp Asp Asp Asp Cys Asn Thr Cys Gln Cys Leu Asn Gly Lys
Val 850 855 860 Thr Cys Ser Lys Val Trp Cys Gly Pro Arg Pro Cys Ile
Ile His Ala 865 870 875 880 Lys Gly His Asn Glu Cys Pro Ala Gly His
Ala Cys Val Pro Val Lys 885 890 895 Glu Asp His Cys Phe Thr His Pro
Cys Ala Ala Val Gly Glu Cys Trp 900 905 910 Pro Ser Asn Gln Gln Pro
Val Lys Thr Lys Cys Asn Ser Asp Ser Tyr 915 920 925 Tyr Gln Asp Asn
Cys Ala Asn Ile Thr Phe Thr Phe Asn Lys Glu Met 930 935 940 Met Ala
Pro Gly Leu Thr Thr Glu His Ile Cys Ser Glu Leu Arg Asn 945 950 955
960 Leu Asn Ile Leu Lys Asn Val Ser Ala Glu Tyr Ser Ile Tyr Ile Thr
965 970 975 Cys Glu Pro Ser His Leu Ala Asn Asn Glu Ile His Val Ala
Ile Ser 980 985 990 Ala Glu Asp Ile Gly Glu Asp Glu Asn Pro Ile Lys
Glu Ile Thr Asp 995 1000 1005 Lys Ile Ile Asp Leu Val Ser Lys Arg
Asp Gly Asn Asn Thr Leu 1010 1015 1020 Ile Ala Ala Val Ala Glu Val
Arg Val Gln Arg Arg Pro Val Lys 1025 1030 1035 Asn Lys Thr Asp Phe
Leu Val Pro Leu Leu Ser Ser Val Leu Thr 1040 1045 1050 Val Ala Trp
Ile Cys Cys Leu Val Thr Val Phe Tyr Trp Cys Ile 1055 1060 1065 Gln
Lys Arg Arg Lys Gln Ser Ser His Thr His Thr Ala Ser Asp 1070 1075
1080 Asp Asn Thr Thr Asn Asn Val Arg Glu Gln Leu Asn Gln Ile Lys
1085 1090 1095 Asn Pro Ile Glu Lys His Gly Ala Asn Thr Val Pro Ile
Lys Asp 1100 1105 1110 Tyr Glu Asn Lys Asn Ser Lys Ile Ala Lys Ile
Arg Thr His Asn 1115 1120 1125 Ser Glu Val Glu Glu Asp Asp Met Asp
Lys His Gln Gln Lys Ala 1130 1135 1140 Arg Phe Ala Lys Gln Pro Ala
Tyr Thr Leu Val Asp Arg Asp Glu 1145 1150 1155 Lys Pro Pro Asn Ser
Thr Pro Thr Lys His Pro Asn Trp Thr Asn 1160 1165 1170
Lys Gln Asp Asn Arg Asp Leu Glu Ser Ala Gln Ser Leu Asn Arg 1175
1180 1185 Met Glu Tyr Ile Val 1190 <210> SEQ ID NO 9
<211> LENGTH: 2088 <212> TYPE: DNA <213>
ORGANISM: Gallus sp. <400> SEQUENCE: 9 gaattcggca cgaggttttt
tttttttttt ttcccctctt ttctttcttt tccttttgcc 60 atccgaaaga
gctgtcagcc gccgccgggc tgcacctaaa ggcgtcggta gggggataac 120
agtcagagac cctcctgaaa gcaggagacg ggacggtacc cctccggctc tgcggggcgg
180 ctgcggcccc tccgttcttt ccccctcccc gagagacact cttcctttcc
ccccacgaag 240 acacaggggc aggaacgcga gcgctgcccc tccgccatgg
gaggccgctt cctgctgacg 300 ctcgccctcc tctcggcgct gctgtgccgc
tgccaggttg acggctccgg ggtgttcgag 360 ctgaagctgc aggagtttgt
caacaagaag gggctgctca gcaaccgcaa ctgctgccgg 420 gggggcggcc
ccggaggcgc cgggcagcag cagtgcgact gcaagacctt cttccgcgtc 480
tgcctgaagc actaccaggc cagcgtctcc cccgagccgc cctgcaccta cggcagcgcc
540 atcacccccg tcctcggcgc caactccttc agcgtccccg acggcgcggg
cggcgccgac 600 cccgccttca gcaaccccat ccgcttcccc ttcggcttca
cctggcccgg caccttctcg 660 ctcatcatcg aggctctgca caccgactcc
cccgacgacc tcaccacaga aaaccccgag 720 cgcctcatca gccgcctggc
cacccagagg cacctggcgg tgggcgagga gtggtcccag 780 gacctgcaca
gcagcggccg caccgacctc aagtactcct atcgctttgt gtgtgatgag 840
cactactacg gggaaggctg ctctgtcttc tgccggcccc gtgacgaccg cttcggtcac
900 ttcacctgtg gagagcgtgg cgagaaggtc tgcaacccag gctggaaggg
ccagtactgc 960 actgagccga tttgcttgcc tgggtgtgac gagcagcacg
gcttctgcga caaacctggg 1020 gaatgcaagt gcagagtggg ttggcagggg
cggtactgtg acgagtgcat ccgataccca 1080 ggctgcctgc acggtacctg
tcagcagcca tggcagtgca actgccagga aggctggggc 1140 ggccttttct
gcaaccagga cctgaactac tgcactcacc acaagccatg caagaatggt 1200
cggtgtacgt ggttgtggcc agtcccctcg atgtgaacaa gaacggctgg acccatgtgt
1260 ggctccagct gcgagattga aatcaacgaa tgtgatgcca acccttgcaa
gaatggtgga 1320 agctgcacgg atctcgagaa cagctattcc tgtacctgcc
ccccaggctt ctatggtaaa 1380 aactgtgagc tgagtgcaat gacttgtgct
gatggaccgt gcttcaatgg agggcgatgc 1440 actgacaacc ctgatggtgg
atacagctgc cgctgcccac tgggttattc tgggttcaac 1500 tgtgaaaaga
aaatcgatta ctgcagttcc agcccttgtg ctaatggagc ccagtgcgtt 1560
gacctgggga actcctacat atgccagtgc caggctggct tcactggcag gcactgtgac
1620 gacaacgtgg acgattgcgc ctccttcccc tgcgtcaatg gagggacctg
tcaggatggg 1680 gtcaacgact actcctgcac ctgccccccg ggatacaacg
ggaagaactg cagcacgccg 1740 gtgagcagat gcgagcacaa cccctgccac
aatggggcca cctgccacga gagaagcaac 1800 cgctacgtgt gcgagtgcgc
tcggggctac ggcggcctca actgccagtt cctgctcccc 1860 gagccacctc
aggggccggt catcgttgac ttcaccgaga agtacacaga gggccagaac 1920
agccagtttc cctggatcgc agtgtgcgcc gggattattc tggtcctcat gctgctgctg
1980 taccagtcgg tgtacgtcat atcagaagag aaagatgagt gcatcatagc
aactgaggtg 2040 taaaacagac gtgacgtggc aaagcttatc gataccgtca
tcaagctt 2088 <210> SEQ ID NO 10 <211> LENGTH: 2883
<212> TYPE: DNA <213> ORGANISM: Gallus sp. <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(829)..(830) <223> OTHER INFORMATION: n is a, c, g, or t
<400> SEQUENCE: 10 gaattcggca cgaggttttt tttttttttt
ttcccctctt ttctttcttt tccttttgcc 60 atccgaaaga gctgtcagcc
gccgccgggc tgcacctaaa ggcgtcggta gggggataac 120 agtcagagac
cctcctgaaa gcaggagacg ggacggtacc cctccggctc tgcggggcgg 180
ctgcggcccc tccgttcttt ccccctcccc gagagacact cttcctttcc ccccacgaag
240 acacaggggc aggaacgcga gcgctgcccc tccgccatgg gaggccgctt
cctgctgacg 300 ctcgccctcc tctcggcgct gctgtgccgc tgccaggttg
acggctccgg ggtgttcgag 360 ctgaagctgc aggagtttgt caacaagaag
gggctgctca gcaaccgcaa ctgctgccgg 420 gggggcggcc ccggaggcgc
cgggcagcag cagtgcgact gcaagacctt cttccgcgtc 480 tgcctgaagc
actaccaggc cagcgtctcc cccgagccgc cctgcaccta cggcagcgcc 540
atcacccccg tcctcggcgc caactccttc agcgtccccg acggcgcggg cggcgccgac
600 cccgccttca gcaaccccat ccgcttcccc ttcggcttca cctggcccgg
caccttctcg 660 ctcatcatcg aggctctgca caccgactcc cccgacgacc
tcaccacaga aaaccccgag 720 cgcctcatca gccgcctggc cacccagagg
cacctggcgg tgggcgagga gtggtcccag 780 gacctgcaca gcagcggccg
caccgacctc aagtactcct atcgctttnn gtgtgatgag 840 cactactacg
gggaaggctg ctctgtcttc tgccggcccc gtgacgaccg cttcggtcac 900
ttcacctgtg gagagcgtgg cgagaaggtc tgcaacccag gctggaaggg ccagtactgc
960 actgagccga tttgcttgcc tgggtgtgac gagcagcacg gcttctgcga
caaacctggg 1020 gaatgcaagt gcagagtggg ttggcagggg cggtactgtg
acgagtgcat ccgataccca 1080 ggctgcctgc acggtacctg tcagcagcca
tggcagtgca actgccagga aggctggggc 1140 ggccttttct gcaaccagga
cctgaactac tgcactcacc acaagccatg caagaatggt 1200 gccacatgca
ccaacaccgg tcaggggagc tacacttgtt cttgccgacc tgggtacaca 1260
ggctccagct gcgagattga aatcaacgaa tgtgatgcca acccttgcaa gaatggtgga
1320 agctgcacgg atctcgagaa cagctattcc tgtacctgcc ccccaggctt
ctatggtaaa 1380 aactgtgagc tgagtgcaat gacttgtgct gatggaccgt
gcttcaatgg agggcgatgc 1440 actgacaacc ctgatggtgg atacagctgc
cgctgcccac tgggttattc tgggttcaac 1500 tgtgaaaaga aaatcgatta
ctgcagttcc agcccttgtg ctaatggagc ccagtgcgtt 1560 gacctgggga
actcctacat atgccagtgc caggctggct tcactggcag gcactgtgac 1620
gacaacgtgg acgattgcgc ctccttcccc tgcgtcaatg gagggacctg tcaggatggg
1680 gtcaacgact actcctgcac ctgccccccg ggatacaacg ggaagaactg
cagcacgccg 1740 gtgagcagat gcgagcacaa cccctgccac aatggggcca
cctgccacga gagaagcaac 1800 cgctacgtgt gcgagtgcgc tcggggctac
ggcggcctca actgccagtt cctgctcccc 1860 gagccacctc aggggccggt
catcgttgac ttcaccgaga agtacacaga gggccagaac 1920 agccagtttc
cctggatcgc agtgtgcgcc gggattattc tggtcctcat gctgctgctg 1980
ggttgcgccg ccatcgtcgt ctgcgtcagg ctgaaggtgc agaagaggca ccaccagccc
2040 gaggcctgca ggagtgaaac ggagaccatg aacaacctgg cgaactgcca
gcgcgagaag 2100 gacatctcca tcagcgtcat cggtgccact cagattaaaa
acacaaataa gaaagtagac 2160 tttcacagcg ataactccga taaaaacggc
tacaaagtta gatacccatc agtggattac 2220 aatttggtgc atgaactcaa
gaatgaggac tctgtgaaag aggagcatgg caaatgcgaa 2280 gccaagtgtg
aaacgtatga ttcagaggca gaagagaaaa gcgcagtaca gctaaaaagt 2340
agtgacactt ctgaaagaaa acggccagat tcagtatatt ccacttcaaa ggacacaaag
2400 taccagtcgg tgtacgtcat atcagaagag aaagatgagt gcatcatagc
aactgaggtt 2460 agtatcccac ctggcagtcg gacaagtctt ggtgtgtgat
tcccatccag cgcaggtcag 2520 ggcggccaaa ccattctacc tgctgccaca
gtcatctgta cccaatgaaa actggccacc 2580 ttcagtctgt ggcactgcag
acgttgaaaa aacttgttgt ggattaacat aagctccagt 2640 gggggttaca
gggacagcaa tttttgcagg caagggtata actgtagtgc agttgtagct 2700
tactaaccct actgactcat tctttcgtgt gcttcctgca gagcctgttt ttgcttggca
2760 ttgaggtgaa gtcctgaccc tctgcatcct catagtcctc tgctttcttt
ttattaacct 2820 cttctggtct ctgcttgtgt tttctctcaa caggtgtaaa
acagacgtga cgtggcaaag 2880 ctt 2883 <210> SEQ ID NO 11
<211> LENGTH: 728 <212> TYPE: PRT <213> ORGANISM:
Gallus sp. <400> SEQUENCE: 11 Met Gly Gly Arg Phe Leu Leu Thr
Leu Ala Leu Leu Ser Ala Leu Leu 1 5 10 15 Cys Arg Cys Gln Val Asp
Gly Ser Gly Val Phe Glu Leu Lys Leu Gln 20 25 30 Glu Phe Val Asn
Lys Lys Gly Leu Leu Ser Asn Arg Asn Cys Cys Arg 35 40 45 Gly Gly
Gly Pro Gly Gly Ala Gly Gln Gln Gln Cys Asp Cys Lys Thr 50 55 60
Phe Phe Arg Val Cys Leu Lys His Tyr Gln Ala Ser Val Ser Pro Glu 65
70 75 80 Pro Pro Cys Thr Tyr Gly Ser Ala Ile Thr Pro Val Leu Gly
Ala Asn 85 90 95 Ser Phe Ser Val Pro Asp Gly Ala Gly Gly Ala Asp
Pro Ala Phe Ser 100 105 110 Asn Pro Ile Arg Phe Pro Phe Gly Phe Thr
Trp Pro Gly Thr Phe Ser 115 120 125 Leu Ile Ile Glu Ala Leu His Thr
Asp Ser Pro Asp Asp Leu Thr Thr 130 135 140 Glu Asn Pro Glu Arg Leu
Ile Ser Arg Leu Ala Thr Gln Arg His Leu 145 150 155 160 Ala Val Gly
Glu Glu Trp Ser Gln Asp Leu His Ser Ser Gly Arg Thr 165 170 175 Asp
Leu Lys Tyr Ser Tyr Arg Phe Val Cys Asp Glu His Tyr Tyr Gly 180 185
190 Glu Gly Cys Ser Val Phe Cys Arg Pro Arg Asp Asp Arg Phe Gly His
195 200 205 Phe Thr Cys Gly Glu Arg Gly Glu Lys Val Cys Asn Pro Gly
Trp Lys 210 215 220 Gly Gln Tyr Cys Thr Glu Pro Ile Cys Leu Pro Gly
Cys Asp Glu Gln 225 230 235 240 His Gly Phe Cys Asp Lys Pro Gly Glu
Cys Lys Cys Arg Val Gly Trp 245 250 255
Gln Gly Arg Tyr Cys Asp Glu Cys Ile Arg Tyr Pro Gly Cys Leu His 260
265 270 Gly Thr Cys Gln Gln Pro Trp Gln Cys Asn Cys Gln Glu Gly Trp
Gly 275 280 285 Gly Leu Phe Cys Asn Gln Asp Leu Asn Tyr Cys Thr His
His Lys Pro 290 295 300 Cys Lys Asn Gly Ala Thr Cys Thr Asn Thr Gly
Gln Gly Ser Tyr Thr 305 310 315 320 Cys Ser Cys Arg Pro Gly Tyr Thr
Gly Ser Ser Cys Glu Ile Glu Ile 325 330 335 Asn Glu Cys Asp Ala Asn
Pro Cys Lys Asn Gly Gly Ser Cys Thr Asp 340 345 350 Leu Glu Asn Ser
Tyr Ser Cys Thr Cys Pro Pro Gly Phe Tyr Gly Lys 355 360 365 Asn Cys
Glu Leu Ser Ala Met Thr Cys Ala Asp Gly Pro Cys Phe Asn 370 375 380
Gly Gly Arg Cys Thr Asp Asn Pro Asp Gly Gly Tyr Ser Cys Arg Cys 385
390 395 400 Pro Leu Gly Tyr Ser Gly Phe Asn Cys Glu Lys Lys Ile Asp
Tyr Cys 405 410 415 Ser Ser Ser Pro Cys Ala Asn Gly Ala Gln Cys Val
Asp Leu Gly Asn 420 425 430 Ser Tyr Ile Cys Gln Cys Gln Ala Gly Phe
Thr Gly Arg His Cys Asp 435 440 445 Asp Asn Val Asp Asp Cys Ala Ser
Phe Pro Cys Val Asn Gly Gly Thr 450 455 460 Cys Gln Asp Gly Val Asn
Asp Tyr Ser Cys Thr Cys Pro Pro Gly Tyr 465 470 475 480 Asn Gly Lys
Asn Cys Ser Thr Pro Val Ser Arg Cys Glu His Asn Pro 485 490 495 Cys
His Asn Gly Ala Thr Cys His Glu Arg Ser Asn Arg Tyr Val Cys 500 505
510 Glu Cys Ala Arg Gly Tyr Gly Gly Leu Asn Cys Gln Phe Leu Leu Pro
515 520 525 Glu Pro Pro Gln Gly Pro Val Ile Val Asp Phe Thr Glu Lys
Tyr Thr 530 535 540 Glu Gly Gln Asn Ser Gln Phe Pro Trp Ile Ala Val
Cys Ala Gly Ile 545 550 555 560 Ile Leu Val Leu Met Leu Leu Leu Gly
Cys Ala Ala Ile Val Val Cys 565 570 575 Val Arg Leu Lys Val Gln Lys
Arg Lys Lys Gln Pro Glu Ala Cys Arg 580 585 590 Ser Glu Thr Glu Thr
Met Asn Asn Leu Ala Asn Cys Gln Arg Glu Lys 595 600 605 Asp Ile Ser
Ile Ser Val Ile Gly Ala Thr Gln Ile Lys Asn Thr Asn 610 615 620 Lys
Lys Val Asp Phe His Ser Asp Asn Ser Asp Lys Asn Gly Tyr Lys 625 630
635 640 Val Arg Tyr Pro Ser Val Asp Tyr Asn Leu Val His Glu Leu Lys
Asn 645 650 655 Glu Asp Ser Val Lys Glu Glu His Gly Lys Cys Glu Ala
Lys Cys Glu 660 665 670 Thr Tyr Asp Ser Glu Ala Glu Glu Lys Ser Ala
Val Gln Leu Lys Ser 675 680 685 Ser Asp Thr Ser Glu Arg Lys Arg Pro
Asp Ser Val Tyr Ser Thr Ser 690 695 700 Lys Asp Thr Lys Tyr Gln Ser
Val Tyr Val Ile Ser Glu Glu Lys Asp 705 710 715 720 Glu Cys Ile Ile
Ala Thr Glu Val 725 <210> SEQ ID NO 12 <211> LENGTH:
721 <212> TYPE: PRT <213> ORGANISM: Xenopus sp.
<400> SEQUENCE: 12 Met Gly Gln Gln Arg Met Leu Thr Leu Leu
Val Leu Ser Ala Val Leu 1 5 10 15 Cys Gln Ile Ser Cys Ser Gly Leu
Phe Glu Leu Arg Leu Gln Glu Phe 20 25 30 Val Asn Lys Lys Gly Leu
Leu Gly Asn Met Asn Cys Cys Arg Pro Gly 35 40 45 Ser Leu Ala Ser
Leu Gln Arg Cys Glu Cys Lys Thr Phe Phe Arg Ile 50 55 60 Cys Leu
Lys His Tyr Gln Ser Asn Val Ser Pro Glu Pro Pro Cys Thr 65 70 75 80
Tyr Gly Gly Ala Val Thr Pro Val Leu Gly Thr Asn Ser Phe Val Val 85
90 95 Pro Glu Ser Ser Asn Ala Asp Pro Thr Phe Ser Asn Pro Ile Arg
Phe 100 105 110 Pro Phe Gly Phe Thr Trp Pro Gly Thr Phe Ser Leu Ile
Ile Glu Ala 115 120 125 Ile His Ala Asp Ser Ala Asp Asp Leu Asn Thr
Glu Asn Pro Glu Arg 130 135 140 Leu Ile Ser Arg Leu Ala Thr Gln Arg
His Leu Thr Val Gly Glu Gln 145 150 155 160 Trp Ser Gln Asp Leu His
Ser Ser Asp Arg Thr Glu Leu Lys Tyr Ser 165 170 175 Tyr Arg Phe Val
Cys Asp Glu Tyr Tyr Tyr Gly Glu Gly Cys Ser Asp 180 185 190 Tyr Cys
Arg Pro Arg Asp Asp Ala Phe Gly His Phe Ser Cys Gly Glu 195 200 205
Lys Gly Glu Lys Leu Cys Asn Pro Gly Trp Lys Gly Leu Tyr Cys Thr 210
215 220 Glu Pro Ile Cys Leu Pro Gly Cys Asp Glu His His Gly Tyr Cys
Asp 225 230 235 240 Lys Pro Gly Glu Cys Lys Cys Arg Val Gly Trp Gln
Gly Arg Tyr Cys 245 250 255 Asp Glu Cys Ile Arg Tyr Pro Gly Cys Leu
His Gly Thr Cys Gln Gln 260 265 270 Pro Trp Gln Cys Asn Cys Gln Glu
Gly Trp Gly Gly Leu Phe Cys Asn 275 280 285 Gln Asp Leu Asn Tyr Cys
Thr His His Lys Pro Cys Glu Asn Gly Ala 290 295 300 Thr Cys Thr Asn
Thr Gly Gln Gly Ser Tyr Thr Cys Ser Cys Arg Pro 305 310 315 320 Gly
Tyr Thr Gly Ser Asn Cys Glu Ile Glu Val Asn Glu Cys Asp Ala 325 330
335 Asn Pro Cys Lys Asn Gly Gly Ser Cys Ser Asp Leu Glu Asn Ser Tyr
340 345 350 Thr Cys Ser Cys Pro Pro Gly Phe Tyr Gly Lys Asn Cys Glu
Leu Ser 355 360 365 Ala Met Thr Cys Ala Asp Gly Pro Cys Phe Asn Gly
Gly Arg Cys Ala 370 375 380 Asp Asn Pro Asp Gly Gly Tyr Ile Cys Phe
Cys Pro Gly Val Tyr Ser 385 390 395 400 Gly Phe Asn Cys Glu Lys Lys
Ile Asp Tyr Cys Ser Ser Asn Pro Cys 405 410 415 Ala Asn Gly Ala Arg
Cys Glu Asp Leu Gly Asn Ser Tyr Ile Cys Gln 420 425 430 Cys Gln Glu
Gly Phe Ser Gly Arg Asn Cys Asp Asp Asn Leu Asp Asp 435 440 445 Cys
Thr Ser Phe Pro Cys Gln Asn Gly Gly Thr Cys Gln Asp Gly Ile 450 455
460 Asn Asp Tyr Ser Cys Thr Cys Pro Pro Gly Tyr Ile Gly Lys Asn Cys
465 470 475 480 Ser Met Pro Ile Thr Lys Cys Glu His Asn Pro Cys His
Asn Gly Ala 485 490 495 Thr Cys His Glu Arg Asn Asn Arg Tyr Val Cys
Gln Cys Ala Arg Gly 500 505 510 Tyr Gly Gly Asn Asn Cys Gln Phe Leu
Leu Pro Glu Glu Lys Pro Val 515 520 525 Val Val Asp Leu Thr Glu Lys
Tyr Thr Glu Gly Gln Ser Gly Gln Phe 530 535 540 Pro Trp Ile Ala Val
Cys Ala Gly Ile Val Leu Val Leu Met Leu Leu 545 550 555 560 Leu Gly
Cys Ala Ala Val Val Val Cys Val Arg Val Arg Val Gln Lys 565 570 575
Arg Arg His Gln Pro Glu Ala Cys Arg Gly Glu Ser Lys Thr Met Asn 580
585 590 Asn Leu Ala Asn Cys Gln Arg Glu Lys Asp Ile Ser Val Ser Phe
Ile 595 600 605 Gly Thr Thr Gln Ile Lys Asn Thr Asn Lys Lys Ile Asp
Phe Leu Ser 610 615 620 Glu Ser Asn Asn Glu Lys Asn Gly Tyr Lys Pro
Arg Tyr Pro Ser Val 625 630 635 640 Asp Tyr Asn Leu Val His Glu Leu
Lys Asn Glu Asp Ser Pro Lys Glu 645 650 655 Glu Arg Ser Lys Cys Glu
Ala Lys Cys Ser Ser Asn Asp Ser Asp Ser 660 665 670 Glu Asp Val Asn
Ser Val His Ser Lys Arg Asp Ser Ser Glu Arg Arg 675 680 685 Arg Pro
Asp Ser Ala Tyr Ser Thr Ser Lys Asp Thr Lys Tyr Gln Ser 690 695 700
Val Tyr Val Ile Ser Asp Glu Lys Asp Glu Cys Ile Ile Ala Thr Glu 705
710 715 720 Val <210> SEQ ID NO 13 <211> LENGTH: 2692
<212> TYPE: DNA <213> ORGANISM: Mus sp. <400>
SEQUENCE: 13 ctgcaggaat tcsmycgcat gctcccggcc gccatgggcc gtcggagcgc
gctagccctt 60 gccgtggtct ctgccctgct gtgccaggtc tggagctccg
gcgtatttga gctgaagctg 120 caggagttcg tcaacaagaa ggggctgctg
gggaaccgca actgctgccg cgggggctct 180 ggcccgcctt gcgcctgcag
gaccttcttt cgcgtatgcc tcaagcacta ccaggccagc 240
gtgtcaccgg agccaccctg cacctacggc agtgccgtca cgccagtgct gggtgtcgac
300 tccttcagcc tgcctgatgg cgcaggcatc gaccccgcct tcagcaaccc
catccgattc 360 cccttcggct tcacctggcc aggtaccttc tctctgatca
ttgaagccct ccatacagac 420 tctcccgatg acctcgcaac agaaaaccca
gaaagactca tcagccgcct gaccacacag 480 aggcacctca ctgtgggaga
agaatggtct caggaccttc acagtagcgg ccgcacagac 540 ctccggtact
cttaccggtt tgtgtgtgac gagcactact acggagaagg ttgctctgtg 600
ttctgccgac ctcgggatga cgcctttggc cacttcacct gcggggacag aggggagaag
660 atgtgcgacc ctggctggaa aggccagtac tgcactgacc caatctgtct
gccagggtgt 720 gatgaccaac atggatactg tgacaaacca ggggagtgca
agtgcagagt tggctggcag 780 ggccgctact gcgatgagtg catccgatac
ccaggttgtc tccatggcac ctgccagcaa 840 ccctggcagt gtaactgcca
ggaaggctgg gggggccttt tctgcaacca agacctgaac 900 tactgtactc
accataagcc gtgcaggaat ggagccacct gcaccaacac gggccagggg 960
agctacacat gttcctgccg acctgggtat acaggtgcca actgtgagct ggaagtagat
1020 gagtgtgctc ctagcccctg caagaacgga gcgagctgca cggaccttga
ggacagcttc 1080 tcttgcacct gccctcccgg cttctatggc aaggtctgtg
agctgagcgc catgacctgt 1140 gcagatggcc cttgcttcaa tggaggacga
tgttcagata accctgacgg aggctacacc 1200 tgccattgcc ccttgggctt
ctctggcttc aactgtgaga agaagatgga tctctgcggc 1260 tcttcccctt
gttctaacgg tgccaagtgt gtggacctcg gcaactctta cctgtgccgg 1320
tgccaggctg gcttctccgg gaggtactgc gaggacaatg tggatgactg tgcctcctcc
1380 ccgtgtgcaa atgggggcac ctgccgggac agtgtgaacg acttctcctg
tacctgccca 1440 cctggctaca cgggcaagaa ctgcagcgcc cctgtcagca
ggtgtgagca tgcaccctgc 1500 cataatgggg ccacctgcca ccagaggggc
cagcgctaca tgtgtgagtg cgcccagggc 1560 tatggcggcc ccaactgcca
gtttctgctc cctgagccac caccagggcc catggtggtg 1620 gacctcagtg
agaggcatat ggagagccag ggcgggccct tcccctgggt ggccgtgtgt 1680
gccggggtgg tgcttgtcct cctgctgctg ctgggctgtg ctgctgtggt ggtctgcgtc
1740 cggctgaagc tacagaaaca ccagcctcca cctgaaccct gtgggggaga
gacagaaacc 1800 atgaacaacc tagccaattg ccagcgcgag aaggacgttt
ctgttagcat cattggggct 1860 acccagatca agaacaccaa caagaaggcg
gactttcacg gggaccatgg agccgagaag 1920 agcagcttta aggtccgata
ccccactgtg gactataacc tcgttcgaga cctcaaggga 1980 gatgaagcca
cggtcaggga tacacacagc aaacgtgaca ccaagtgcca gtcacagagc 2040
tctgcaggag aagagaagat cgccccaaca cttaggggtg gggagattcc tgacagaaaa
2100 aggccagagt ctgtctactc tacttcaaag gacaccaagt accagtcggt
gtatgttctg 2160 tctgcagaaa aggatgagtg tgttatagcg actgaggtgt
aagatggaag cgatgtggca 2220 aaattcccat ttctcttaaa taaaattcca
aggatatagc cccgatgaat gctgctgaga 2280 gaggaaggga gaggaaaccc
agggactgct gctgagaacc aggttcaggc gaacgtggtt 2340 ctctcagagt
tagcagaggc gcccgacact gccagcctag gctttggctg ccgctggact 2400
gcctgctggt tgttcccatt gcactatgga cagttgcttt gaagagtata tatttaaatg
2460 gacgagtgac ttgattcata taggaagcac gcactgccca cacgtctatc
ttggattact 2520 atgagccagt ctttccttga actagaaaca caactgcctt
tattgtcctt tttgatactg 2580 agatgtgttt tttttttttc ctagacggga
aaaagaaaac gtgtgttatt ttttttggga 2640 tttgtaaaaa tatttttcat
gattatggga gagctcccaa cgcgttggag gt 2692 <210> SEQ ID NO 14
<211> LENGTH: 722 <212> TYPE: PRT <213> ORGANISM:
Mus sp. <400> SEQUENCE: 14 Met Gly Arg Arg Ser Ala Leu Ala
Leu Ala Val Val Ser Ala Leu Leu 1 5 10 15 Cys Gln Val Trp Ser Ser
Gly Val Phe Glu Leu Lys Leu Gln Glu Phe 20 25 30 Val Asn Lys Lys
Gly Leu Leu Gly Asn Arg Asn Cys Cys Arg Gly Gly 35 40 45 Ser Gly
Pro Pro Cys Ala Cys Arg Thr Phe Phe Arg Val Cys Leu Lys 50 55 60
His Tyr Gln Ala Ser Val Ser Pro Glu Pro Pro Cys Thr Tyr Gly Ser 65
70 75 80 Ala Val Thr Pro Val Leu Gly Val Asp Ser Phe Ser Leu Pro
Asp Gly 85 90 95 Ala Gly Ile Asp Pro Ala Phe Ser Asn Pro Ile Arg
Phe Pro Phe Gly 100 105 110 Phe Thr Trp Pro Gly Thr Phe Ser Leu Ile
Ile Glu Ala Leu His Thr 115 120 125 Asp Ser Pro Asp Asp Leu Ala Thr
Glu Asn Pro Glu Arg Leu Ile Ser 130 135 140 Arg Leu Thr Thr Gln Arg
His Leu Thr Val Gly Glu Glu Trp Ser Gln 145 150 155 160 Asp Leu His
Ser Ser Gly Arg Thr Asp Leu Arg Tyr Ser Tyr Arg Phe 165 170 175 Val
Cys Asp Glu His Tyr Tyr Gly Glu Gly Cys Ser Val Phe Cys Arg 180 185
190 Pro Arg Asp Asp Ala Phe Gly His Phe Thr Cys Gly Asp Arg Gly Glu
195 200 205 Lys Met Cys Asp Pro Gly Trp Lys Gly Gln Tyr Cys Thr Asp
Pro Ile 210 215 220 Cys Leu Pro Gly Cys Asp Asp Gln His Gly Tyr Cys
Asp Lys Pro Gly 225 230 235 240 Glu Cys Lys Cys Arg Val Gly Trp Gln
Gly Arg Tyr Cys Asp Glu Cys 245 250 255 Ile Arg Tyr Pro Gly Cys Leu
His Gly Thr Cys Gln Gln Pro Trp Gln 260 265 270 Cys Asn Cys Gln Glu
Gly Trp Gly Gly Leu Phe Cys Asn Gln Asp Leu 275 280 285 Asn Tyr Cys
Thr His His Lys Pro Cys Arg Asn Gly Ala Thr Cys Thr 290 295 300 Asn
Thr Gly Gln Gly Ser Tyr Thr Cys Ser Cys Arg Pro Gly Tyr Thr 305 310
315 320 Gly Ala Asn Cys Glu Leu Glu Val Asp Glu Cys Ala Pro Ser Pro
Cys 325 330 335 Lys Asn Gly Ala Ser Cys Thr Asp Leu Glu Asp Ser Phe
Ser Cys Thr 340 345 350 Cys Pro Pro Gly Phe Tyr Gly Lys Val Cys Glu
Leu Ser Ala Met Thr 355 360 365 Cys Ala Asp Gly Pro Cys Phe Asn Gly
Gly Arg Cys Ser Asp Asn Pro 370 375 380 Asp Gly Gly Tyr Thr Cys His
Cys Pro Leu Gly Phe Ser Gly Phe Asn 385 390 395 400 Cys Glu Lys Lys
Met Asp Leu Cys Gly Ser Ser Pro Cys Ser Asn Gly 405 410 415 Ala Lys
Cys Val Asp Leu Gly Asn Ser Tyr Leu Cys Arg Cys Gln Ala 420 425 430
Gly Phe Ser Gly Arg Tyr Cys Glu Asp Asn Val Asp Asp Cys Ala Ser 435
440 445 Ser Pro Cys Ala Asn Gly Gly Thr Cys Arg Asp Ser Val Asn Asp
Phe 450 455 460 Ser Cys Thr Cys Pro Pro Gly Tyr Thr Gly Lys Asn Cys
Ser Ala Pro 465 470 475 480 Val Ser Arg Cys Glu His Ala Pro Cys His
Asn Gly Ala Thr Cys His 485 490 495 Gln Arg Gly Gln Arg Tyr Met Cys
Glu Cys Ala Gln Gly Tyr Gly Gly 500 505 510 Pro Asn Cys Gln Phe Leu
Leu Pro Glu Pro Pro Pro Gly Pro Met Val 515 520 525 Val Asp Leu Ser
Glu Arg His Met Glu Ser Gln Gly Gly Pro Phe Pro 530 535 540 Trp Val
Ala Val Cys Ala Gly Val Val Leu Val Leu Leu Leu Leu Leu 545 550 555
560 Gly Cys Ala Ala Val Val Val Cys Val Arg Leu Lys Leu Gln Lys His
565 570 575 Gln Pro Pro Pro Glu Pro Cys Gly Gly Glu Thr Glu Thr Met
Asn Asn 580 585 590 Leu Ala Asn Cys Gln Arg Glu Lys Asp Val Ser Val
Ser Ile Ile Gly 595 600 605 Ala Thr Gln Ile Lys Asn Thr Asn Lys Lys
Ala Asp Phe His Gly Asp 610 615 620 His Gly Ala Glu Lys Ser Ser Phe
Lys Val Arg Tyr Pro Thr Val Asp 625 630 635 640 Tyr Asn Leu Val Arg
Asp Leu Lys Gly Asp Glu Ala Thr Val Arg Asp 645 650 655 Thr His Ser
Lys Arg Asp Thr Lys Cys Gln Ser Gln Ser Ser Ala Gly 660 665 670 Glu
Glu Lys Ile Ala Pro Thr Leu Arg Gly Gly Glu Ile Pro Asp Arg 675 680
685 Lys Arg Pro Glu Ser Val Tyr Ser Thr Ser Lys Asp Thr Lys Tyr Gln
690 695 700 Ser Val Tyr Val Leu Ser Ala Glu Lys Asp Glu Cys Val Ile
Ala Thr 705 710 715 720 Glu Val <210> SEQ ID NO 15
<211> LENGTH: 525 <212> TYPE: DNA <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 15 tacgatgaay aacctggcga
actgccagcg tcagaaggac atctcagtca gcatcatcgg 60 ggcyacgtca
gatcargaac accaacaaga aggcggactt ymcascgggg gaccasagcg 120
tccgacaaga atggmtttca aggccygcta ccccagcgtg gactataact cgtgcaggac
180 ctcaagggtg acgacaccgc cgtcaggacg tcgcacagca agcgtgacac
caagtgccag 240 tccccaggct cctcagggag gagaagggga ccccgaccac
actcaggggk tgcgtgctgc 300 gggccgggct caggaggggg tacctggggg
gtgtcttcct ggaaccactg ctccgtttct 360 cttcccaaat gttctcatgc
attcattgtg gattttctct attttccttt tagtggagaa 420 gcatctgaaa
gaaaaaggcc ggactcgggc tgttcaactt caaaagacac caagtaccag 480
tcggtgtacg tcatatccga ggagaaggac gagtgcgtca tcgca 525 <210>
SEQ ID NO 16 <211> LENGTH: 1981 <212> TYPE: DNA
<213> ORGANISM: Homo sapiens <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (559)..(559)
<223> OTHER INFORMATION: n is a, c, g, or t <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(678)..(678) <223> OTHER INFORMATION: n is a, c, g, or t
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (689)..(689) <223> OTHER INFORMATION: n is a, c, g,
or t <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (1246)..(1246) <223> OTHER INFORMATION:
n is a, c, g, or t <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (1287)..(1287) <223> OTHER
INFORMATION: n is a, c, g, or t <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (1492)..(1492)
<223> OTHER INFORMATION: n is a, c, g, or t <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(1524)..(1524) <223> OTHER INFORMATION: n is a, c, g, or t
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (1569)..(1569) <223> OTHER INFORMATION: n is a, c,
g, or t <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (1621)..(1621) <223> OTHER INFORMATION:
n is a, c, g, or t <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (1656)..(1656) <223> OTHER
INFORMATION: n is a, c, g, or t <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (1738)..(1738)
<223> OTHER INFORMATION: n is a, c, g, or t <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(1857)..(1857) <223> OTHER INFORMATION: n is a, c, g, or t
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (1861)..(1861) <223> OTHER INFORMATION: n is a, c,
g, or t <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (1876)..(1876) <223> OTHER INFORMATION:
n is a, c, g, or t <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (1888)..(1888) <223> OTHER
INFORMATION: n is a, c, g, or t <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (1899)..(1899)
<223> OTHER INFORMATION: n is a, c, g, or t <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(1917)..(1917) <223> OTHER INFORMATION: n is a, c, g, or t
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (1925)..(1925) <223> OTHER INFORMATION: n is a, c,
g, or t <220> FEATURE: <221> NAME/KEY: misc_feature
<222> LOCATION: (1931)..(1931) <223> OTHER INFORMATION:
n is a, c, g, or t <220> FEATURE: <221> NAME/KEY:
misc_feature <222> LOCATION: (1935)..(1935) <223> OTHER
INFORMATION: n is a, c, g, or t <220> FEATURE: <221>
NAME/KEY: misc_feature <222> LOCATION: (1942)..(1943)
<223> OTHER INFORMATION: n is a, c, g, or t <220>
FEATURE: <221> NAME/KEY: misc_feature <222> LOCATION:
(1952)..(1954) <223> OTHER INFORMATION: n is a, c, g, or t
<220> FEATURE: <221> NAME/KEY: misc_feature <222>
LOCATION: (1968)..(1968) <223> OTHER INFORMATION: n is a, c,
g, or t <400> SEQUENCE: 16 cattgggtac gggcccccct cgaggtcgac
ggtatcgata agcttgatat cgaattccgg 60 cttcacctgg ccgggcacct
tctctctgat tattgaagct ctccacacag attctcctga 120 tgacctcgca
acagaaaacc cagaaagact catcagccgc ctggccaccc agaggcacct 180
gacggtgggc gaggagtggt cccaggacct gcacagcagc ggccgcacgg acctcaagta
240 ctcctaccgc ttcgtgtgtg acgaacacta ctacggagag ggctgctccg
ttttctgccg 300 tccccgggac gatgccttcg gccacttcac ctgtggggag
cgtggggaga aagtgtgcaa 360 ccctggctgg aaagggccct actgcacaga
gccgatctgc ctgcctggat gtgatgagca 420 gcatggattt tgtgacaaac
cagcccaatg caagtgcaga gtgggctggc agggccggta 480 ctgtgacgag
tgtatccgct atccaggctg tctccatggc acctgccagc agccctggca 540
gtgcaactgc caggaaggnt gggggggcct tttctgcaac caggacctga actactgcac
600 acaccataag ccctgcaaga atcgagccac ctgcaacaaa cacgggccag
ggggagctac 660 acttggtctt tggccggnct ggggtacana gggtgccacc
tgcgaagctt ggggattgga 720 cgagttgttg accccagccc ttggtaagaa
cggagggagc ttgacggatc ttcggagaac 780 agctactcct gtacctgccc
acccggcttc tacggcaaaa tctgtgaatt gagtgccatg 840 acctgtgcgg
acggcccttg ctttaacggg ggtcggtgct cagacagccc cgatggaggg 900
tacagctgcc gctgccccgt gggctactcc ggcttcaact gtgagaagaa aattgactac
960 tgcagctctt caccctgttc taatggtgcc aagtgtgtgg acctcggtga
tgcctacctg 1020 tgccgctgcc aggccggctt ctcggggagg cactgtgacg
acaacgtgga cgactgcgcc 1080 tcctccccgt gcgccaacgg gggcacctgc
cgggatggcg tgaacgactt ctcctgcacc 1140 tgcccgcctg gctacacggg
caggaactgc agtgcccccg ccagcaggtg cgagcacgca 1200 ccctgccaca
atggggccac ctgccacgag aggggccacc gctatntgtg cgagtgtgcc 1260
cgaagctacg ggggtcccaa ctgccanttc ctgctccccg aaactgcccc cccggcccca
1320 cggtggtgga aactccccta aaaaaaccta aaagggccgg ggggggccca
tccccttggt 1380 ggacgtgtgc gccggggtca tccttgtcct catgctgctg
ctgggctgtc ccgctgtggt 1440 ggtctgcgtc cggctgaggc tgcagaagca
ccggccccca gccgacccct gncgggggga 1500 gacggagacc atgaacaacc
tggncaactg ccagcgtgag aaggacatct cagtcagcat 1560 catcggggnc
acgcagatca agaacaccaa caagaaggcg gacttccacg gggaccacag 1620
ngccgacaag aatggcttca aggcccgcta cccagnggtg gactataacc tcgtgcagga
1680 cctcaagggt gacgacaccg ccgtcaggga cgcgcacagc aagcgtgaca
ccaagtgnca 1740 gccccagggc tcctcagggg aggagaaggg gacccccgac
ccacactcag ggggtggagg 1800 aagcatcttg aaagaaaaag gccggacttc
gggcttgttc aactttcaaa agacaancaa 1860 ngtacaagtc ggtgtncgtc
atttccgnag gaggaaggnt gactgcgtca taggaanttg 1920 aggtngtaaa
ntggnagttg annttggaaa gnnntccccc gattcccntt tcaaagtttt 1980 t 1981
<210> SEQ ID NO 17 <211> LENGTH: 192 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 17 Gly
Phe Thr Trp Pro Gly Thr Phe Ser Leu Ile Ile Glu Ala Leu His 1 5 10
15 Thr Asp Ser Pro Asp Asp Leu Ala Thr Glu Asn Pro Glu Arg Leu Ile
20 25 30 Ser Arg Leu Ala Thr Gln Arg His Leu Thr Val Gly Glu Glu
Trp Ser 35 40 45 Gln Asp Leu His Ser Ser Gly Arg Thr Asp Leu Lys
Tyr Ser Tyr Arg 50 55 60 Phe Val Cys Asp Glu His Tyr Tyr Gly Glu
Gly Cys Ser Val Phe Cys 65 70 75 80 Arg Pro Arg Asp Asp Ala Phe Gly
His Phe Thr Cys Gly Glu Arg Gly 85 90 95 Glu Lys Val Cys Asn Pro
Gly Trp Lys Gly Pro Tyr Cys Thr Glu Pro 100 105 110 Ile Cys Leu Pro
Gly Cys Asp Glu Gln His Gly Phe Cys Asp Lys Pro 115 120 125 Gly Glu
Cys Lys Cys Arg Val Gly Trp Gln Gly Arg Tyr Cys Asp Glu 130 135 140
Cys Ile Arg Tyr Pro Gly Cys Leu His Gly Thr Cys Gln Gln Pro Trp 145
150 155 160 Gln Cys Asn Cys Gln Glu Gly Trp Gly Gly Leu Phe Cys Asn
Gln Asp 165 170 175 Leu Asn Tyr Cys Thr His His Lys Pro Cys Lys Asn
Gly Ala Thr Cys 180 185 190 <210> SEQ ID NO 18 <211>
LENGTH: 6 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<300> PUBLICATION INFORMATION: <310> PATENT DOCUMENT
NUMBER: WO 9701571 Fig 14 <312> PUBLICATION DATE: 1997-01-16
<400> SEQUENCE: 18 Thr Asn Thr Gly Gln Gly 1 5 <210>
SEQ ID NO 19 <211> LENGTH: 9 <212> TYPE: PRT
<213> ORGANISM: Homo sapiens <400> SEQUENCE: 19 Lys Asn
Gly Gly Ser Leu Thr Asp Leu 1 5 <210> SEQ ID NO 20
<211> LENGTH: 157 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 20 Glu Asn Ser Tyr Ser Cys Thr
Cys Pro Pro Gly Phe Tyr Gly Lys Ile 1 5 10 15 Cys Glu Leu Ser Ala
Met Thr Cys Ala Asp Gly Pro Cys Phe Asn Gly
20 25 30 Gly Arg Cys Ser Asp Ser Pro Asp Gly Gly Tyr Ser Cys Arg
Cys Pro 35 40 45 Val Gly Tyr Ser Gly Phe Asn Cys Glu Lys Lys Ile
Asp Tyr Cys Ser 50 55 60 Ser Ser Pro Cys Ser Asn Gly Ala Lys Cys
Val Asp Leu Gly Asp Ala 65 70 75 80 Tyr Leu Cys Arg Cys Gln Ala Gly
Phe Ser Gly Arg His Cys Asp Asp 85 90 95 Asn Val Asp Asp Cys Ala
Ser Ser Pro Cys Ala Asn Gly Gly Thr Cys 100 105 110 Arg Asp Gly Val
Asn Asp Phe Ser Cys Thr Cys Pro Pro Gly Tyr Thr 115 120 125 Gly Arg
Asn Cys Ser Ala Pro Ala Ser Arg Cys Glu His Ala Pro Cys 130 135 140
His Asn Gly Ala Thr Cys His Glu Arg Gly His Arg Tyr 145 150 155
<210> SEQ ID NO 21 <211> LENGTH: 12 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 21 Cys
Glu Cys Ala Arg Ser Tyr Gly Gly Pro Asn Cys 1 5 10 <210> SEQ
ID NO 22 <211> LENGTH: 5 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 22 Phe Leu Leu Pro Glu
1 5 <210> SEQ ID NO 23 <211> LENGTH: 4 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
23 Pro Pro Gly Pro 1 <210> SEQ ID NO 24 <211> LENGTH:
25 <212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 24 Leu Leu Leu Gly Cys Ala Ala Val Val Val
Cys Val Arg Leu Arg Leu 1 5 10 15 Gln Lys His Arg Pro Pro Ala Asp
Pro 20 25 <210> SEQ ID NO 25 <211> LENGTH: 10
<212> TYPE: PRT <213> ORGANISM: Homo sapiens
<400> SEQUENCE: 25 Arg Gly Glu Thr Glu Thr Met Asn Asn Leu 1
5 10 <210> SEQ ID NO 26 <211> LENGTH: 14 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
26 Asn Cys Gln Arg Glu Lys Asp Ile Ser Val Ser Ile Ile Gly 1 5 10
<210> SEQ ID NO 27 <211> LENGTH: 16 <212> TYPE:
PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE: 27 Thr
Gln Ile Lys Asn Thr Asn Lys Lys Ala Asp Phe His Gly Asp His 1 5 10
15 <210> SEQ ID NO 28 <211> LENGTH: 11 <212>
TYPE: PRT <213> ORGANISM: Homo sapiens <400> SEQUENCE:
28 Ala Asp Lys Asn Gly Phe Lys Ala Arg Tyr Pro 1 5 10 <210>
SEQ ID NO 29 <211> LENGTH: 26 <212> TYPE: PRT
<213> ORGANISM: Homo sapiens <400> SEQUENCE: 29 Val Asp
Tyr Asn Leu Val Gln Asp Leu Lys Gly Asp Asp Thr Ala Val 1 5 10 15
Arg Asp Ala His Ser Lys Arg Asp Thr Lys 20 25 <210> SEQ ID NO
30 <211> LENGTH: 13 <212> TYPE: PRT <213>
ORGANISM: Homo sapiens <400> SEQUENCE: 30 Gln Pro Gln Gly Ser
Ser Gly Glu Glu Lys Gly Thr Pro 1 5 10 <210> SEQ ID NO 31
<211> LENGTH: 4 <212> TYPE: PRT <213> ORGANISM:
Homo sapiens <400> SEQUENCE: 31 Pro Thr Leu Arg 1 <210>
SEQ ID NO 32 <211> LENGTH: 4 <212> TYPE: PRT
<213> ORGANISM: Homo sapiens <400> SEQUENCE: 32 Arg Lys
Arg Pro 1
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