U.S. patent application number 11/039376 was filed with the patent office on 2006-02-16 for cosmetic and dermatological light protection formulations.
This patent application is currently assigned to Beiersdorf AG. Invention is credited to Kerstin Hoop, Heike Lerg, Anja Sabine Mueller, Bente Nissen, Melanie Steinforth, Martin Sugar.
Application Number | 20060034785 11/039376 |
Document ID | / |
Family ID | 34744939 |
Filed Date | 2006-02-16 |
United States Patent
Application |
20060034785 |
Kind Code |
A1 |
Hoop; Kerstin ; et
al. |
February 16, 2006 |
Cosmetic and dermatological light protection formulations
Abstract
Light protective cosmetic or dermatological preparation,
characterized in that it comprises (a) PEG-30
dipolyhydroxystearate, (b) 2-ethylhexyl
2-cyano-3,3-diphenylacrylate, (c) at least one dibenzoylmethane
derivative and (d) at least 2% by weight of titanium dioxide
particles (based on the total weight of the preparation), the
preparation being free from water-soluble UV-A filter
substances.
Inventors: |
Hoop; Kerstin; (Pinneberg,
DE) ; Lerg; Heike; (Hamburg, DE) ; Mueller;
Anja Sabine; (Rumpel, DE) ; Nissen; Bente;
(Hamburg, DE) ; Steinforth; Melanie; (Hamburg,
DE) ; Sugar; Martin; (Hamburg, DE) |
Correspondence
Address: |
ALSTON & BIRD LLP;BANK OF AMERICA PLAZA
101 SOUTH TRYON STREET, SUITE 4000
CHARLOTTE
NC
28280-4000
US
|
Assignee: |
Beiersdorf AG
|
Family ID: |
34744939 |
Appl. No.: |
11/039376 |
Filed: |
January 19, 2005 |
Current U.S.
Class: |
424/59 |
Current CPC
Class: |
A61K 8/40 20130101; A61K
8/86 20130101; A61K 8/29 20130101; A61Q 17/04 20130101; A61K 8/35
20130101 |
Class at
Publication: |
424/059 |
International
Class: |
A61K 8/49 20060101
A61K008/49; A61K 8/18 20060101 A61K008/18 |
Foreign Application Data
Date |
Code |
Application Number |
Jan 19, 2004 |
DE |
10 2004 003 001.4 |
Claims
1. A light protective cosmetic or dermatological preparation
comprising: (a) PEG-30 dipolyhydroxystearate, (b) 2-ethylhexyl
2-cyano-3,3-diphenylacrylate, (c) at least one dibenzoylmethane
derivative, and (d) at least 2% by weight of titanium dioxide
particles based on the total weight of the preparation, the
preparation being free of water-soluble UV-A filter substances.
2. The preparation according to claim 1, wherein the amount of wax
in the preparation is less than 1.5% by weight, based on the total
weight of the preparation.
3. The preparation according to claim 1, wherein the amount of wax
in the preparation is less than 1% by weight, based on the total
weight of the preparation.
4. The preparation according to claim 1, wherein the preparation
comprises no further emulsifiers.
5. The preparation according to claim 1, wherein the amount of
titanium dioxide in the preparation is greater than the amount of
said 2-ethylhexyl 2-cyano-3,3-diphenylacrylate and greater than the
amount of said dibenzoylmethane derivative.
6. The preparation according to claim 1, further comprising an oil
phase fraction, said oil phase fraction being present in said
preparation in an amount that is at least 35% by weight, based on
the total weight of the preparation.
7. The preparation according to claim 1, further comprising a water
phase fraction.
8. A composition in the form of an oil-in-water emulsion
comprising: an oil phase; an aqueous phase; PEG-30
dipolyhydroxystearate, and a UV-A filter consisting essentially of
a combination of titanium dioxide particles, 2-ethylhexyl
2-cyano-3,3-diphenylacrylate, and at least one dibenzoylmethane
derivative.
9. The composition according to claim 8, wherein the amount of said
UV-A filter in said composition is at least 10 percent by weight,
based on the total weight of the composition.
10. The composition according to claim 8, further comprising one or
more active ingredients selected from the group consisting of
antioxidants, .alpha.-lipoic acid, phytoene, D-biotin, coenzyme
Q10, .alpha.-glucosylrutin, carnitine, carnosine, isoflavonoids,
creatine, taurine, .beta.-alanine, 8-hexadecene-1, and
16-dicarboxylic acid.
11. The composition according to claim 8, further comprising
vitamin E, vitamin A, or a combination thereof in an amount from
about 0.001 to 10% by weight, based on the total weight of the
composition.
12. The composition according to claim 8, wherein the amount of
said PEG-30 dipolyhydroxystearate is from 1 to 5% weight percent,
based on the total weight of the composition.
13. The composition according to claim 8, wherein said at least one
dibenzoylmethane derivative comprises
4-(tert-butyl)-4'-methoxydibenzoylmethane,
2,2'-methylenebis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)ph-
enol), or a combination thereof.
14. The composition according to claim 8, further comprising one or
more of preservatives, preservative aids, complexing agents,
bactericides, perfumes, foaming substances, defoaming substances,
dyes, pigments, thickeners, moisturizing substances, humectant
substances, fillers, fats, oils, waxes, alcohols, polyols,
polymers, foam stabilizers, electrolytes, organic solvents or
silicone derivatives.
15. The composition according to claim 8, wherein the composition
has a viscosity that is less than 10 000 mPa s.
16. A cosmetic or dermatogical composition comprising: 2 to 5% by
weight PEG-30 dipolyhydroxystearate based on the total weight of
the preparation; and a UV-A filter substance consisting essentially
of 2-ethylhexyl 2-cyano-3,3-diphenylacrylate; at least one
dibenzoylmethane derivative; and at least 2% by weight of titanium
dioxide particles based on the total weight of the preparation,
said titanium dioxide particles having a coating thereon.
17. A composition according to claim 16, wherein said coating is
selected from the group consisting of aluminium hydroxide/stearic
acid, alumina/simethicone, octyltrimethylsilane, and
alumina/silica.
18. A composition according to claim 16, wherein the amount of
titanium dioxide particles is from about 2 to 6.5 weight percent,
based on the total weight of the composition.
19. A composition according to claim 16, further comprising a UV-B
filter.
20. A composition according to claim 16, further comprising a water
phase and an oil phase.
Description
[0001] The present invention relates to cosmetic and dermatological
light protection preparations, in particular it relates to cosmetic
and dermatological formulations with increased UV-A protection
performance.
[0002] The harmful effect of the ultraviolet part of solar
radiation on the skin is generally known. Depending on their
particular wavelength, the rays have different effects on the skin
as an organ:
[0003] The so-called UV-C radiation with a wavelength between 100
and 280 nm is absorbed by the ozone layer in the Earth's atmosphere
and accordingly is not found in the solar spectrum. It is therefore
of no physiological importance during sunbathing.
[0004] The so-called UV-B region is between 290 nm and 320 nm. UV-B
rays are essentially responsible for the long-lasting tanning of
the skin, but can at the same time cause an erythema, simple
sunburn or even burns of greater or lesser severity. Chronic
photodamage, photodermatoses and Herpes solaris can also be caused
by UV-B radiation.
[0005] It has for a long time been incorrectly assumed that
long-wave UV-A radiation with a wavelength between 320 nm and 400
nm only has a negligible biological effect and that,
correspondingly, the UV-B rays are responsible for most photodamage
to the human skin. However, in the meantime, numerous studies have
demonstrated that UV-A radiation is much more hazardous than UV-B
radiation with regard to the triggering of photodynamic,
specifically phototoxic reactions and chronic changes in the skin.
The harmful influence of UV-B radiation can also be further
intensified by UV-A radiation.
[0006] Thus, it has, inter alia, been found that even UV-A
radiation suffices under very normal everyday conditions to harm,
within a short time, the collagen and elastin fibres which are of
essential importance for the structure and strength of the skin.
The consequences are chronic photo-induced changes in the skin--the
skin "ages" prematurely. The clinical appearance of skin aged by
light includes, for example, wrinkles and lines, and also an
irregular, furrowed relief. In addition, the areas affected by
photo-induced skin ageing can have irregular pigmentation. The
formation of brown spots, keratoses and even carcinomas or
malignant melanomas is also possible. Skin aged prematurely by
everyday UV exposure is, moreover, characterized by lower activity
of the Langerhans cells and slight, chronic inflammation.
[0007] Approximately 90% of the ultraviolet radiation which reaches
the Earth consists of UV-A rays. While UV-B radiation varies widely
depending on numerous factors (e.g. time of year and time of day or
degree of latitude), UV-A radiation remains relatively constant day
to day irrespective of the time of year and time of day or
geographical factors. At the same time, the majority of UV-A
radiation penetrates into the living epidermis, while approximately
70% of UV-B rays are retained by the horny layer.
[0008] The relatively recent findings concerning the effect of UV-A
rays on the skin have led to increased attention now being devoted
to protective measures for this ray range. In practice, no
sunscreen product is complete any more without an effective UV-A
filter effect, and pure UV-B filter preparations are rare.
[0009] When applying a sunscreen to the skin, the ultraviolet rays
can be weakened through two effects: firstly, by reflection and
scattering of the rays at the surface of pulverulent solids
(physical light protection) and, secondly, by absorption on
chemical substances (chemical light protection). Depending on which
wavelength region is absorbed, a distinction is made between UV-B
filters (absorption range 280 to 320 nm), UV-A filters (absorption
range 320 to 400 nm) and broadband filters (absorption range 290 to
about 380 nm).
[0010] To protect against UV-B radiation, numerous compounds are
known, the absorption maximum of which should be around 308 nm as
far as possible since this is the highest erythema effectiveness of
solar radiation. Typical UV-B filters are, for example, derivatives
of 3-benzylidenecamphor, of 4-aminobenzoic acid, of cinnamic acid,
of salicylic acid, of benzophenone, and also of
2-phenylbenzimidazole.
[0011] Some compounds are also known for protecting against UV-A
radiation, such as, in particular, dibenzoylmethane derivatives.
However, dibenzoylmethane derivatives are generally not
photostable, as a result of which cosmetic or dermatological
preparations with a content of this substance should also comprise
certain UV stabilizers.
[0012] Besides the pure UV-A or UV-B filters, there are substances
which cover both regions. This group of broadband filters includes,
for example, asymmetrically substituted s-triazine compounds, such
as, for example,
2,4-bis{[4-(2-ethylhexyloxy)-2-hydroxy]phenyl}-6-(4-methoxypheny-
l)-1,3,5-triazine (INCI: BisEthylhexyloxyphenol Methoxyphenyl
Triazine), certain benzophenones, such as, for example,
2-hydroxy-4-methoxybenzophenone (INCI: Benzophenone 3) or
2,2'-methylenebis(6-(2H-benzotriazole-2-yl)-4-(1,1,3,3-tetramethylbutyl)p-
henol) (INCI: Methylene Bis-Benzotriazolyl
Tetramethylenebutylphenol).
[0013] In general, the light absorption behaviour of light
protection filter substances is very well known and documented,
especially as there are positive lists for the use of such
substances in most industrialized countries, which impose very
strict standards on the documentation. Since, in order to
characterize a filter substance, not only is the position of the
absorption maximum important, but primarily the absorption range,
absorption spectra are recorded for each substance. However, the
absorbance values can at best be a guide for the concentration of
the substances in the finished formulations since interactions with
ingredients of the skin or of the surface of the skin itself may
give rise to imponderables. In addition, it is usually difficult to
estimate beforehand how uniformly and thickly the filter substance
is distributed in and on the horny layer of the skin.
[0014] To test the UV-A protection performance, use is usually made
of the IPD method (IPD immediate pigment darkening). Similarly to
the determination of the sun protection factor, this method gives a
value which indicates how much longer the skin protected with the
light protection composition can be irradiated with UV-A radiation
until the pigmentation which occurs is the same as for the
unprotected skin.
[0015] The use concentration of known light protection filter
substances which exhibit a high filter effect particularly also in
the UV-A region is, however, often limited--especially in
combination with other substances to be dissolved. In order, for
example, to be able to use large amounts of oil-soluble UV filter
substances, a very large oil phase (>about 35% by weight) would
be required. However, the hydrophobic phase of an emulsion--for
example of a W/O emulsion--could not be chosen to be arbitrarily
large since the size of the phases also decisively influences the
stability of an emulsion. If a large oil phase (of more than about
35% by weight) is desired, according to the prior art, stabilizers
such as waxes or further emulsifiers have to be used in order to
obtain an emulsion with a long-term stability of several years.
However, a disadvantage of this procedure is that the emulsions
become relatively solid as a result and can no longer be
distributed as well--particularly on hairy skin.
[0016] A further method known according to the prior art for
preparing light protection preparations with very high light
protection factors (LPF greater than 25) consists in combining UV
filter substances such that the entire amount of UV filter is not
in the oil phase of the emulsion, which is of course only possible
if water-soluble UV filter substances are also used. A disadvantage
of such emulsions which comprise water-soluble UV filter substances
is that these are usually only water-resistant to a limited
extent.
[0017] The water resistance of light protection formulations is,
however, attributed particular importance since most sunscreen
compositions are applied in the vicinity of water or during
sporting activity (sweating). A water-resistant sunscreen
composition protects the user not only after bathing, but also
protects him against sunburn during bathing. It is a widespread
misconception that water offers good or even adequate protection
against ultraviolet radiation. Rather, investigations have shown
that even 1 m below the surface of the water, the transmittance for
UV-B rays is about 50%. It is therefore advisable for those who
participate in water sports, who, for example, swim, surf or
snorkel, and in particular children, who often play for hours at or
in the water, to also protect the skin against overly intense and
excessive solar irradiation with a sun product which adheres well
and can only be rinsed off with difficulty by (salt) water and
perspiration.
[0018] For the purposes of optimum water resistance, the omission
of water-soluble UV filters would therefore be desirable.
[0019] It was therefore an object of the present invention to
arrive, in a simple and cost-effective manner, at preparations
which achieve high UV-A protection performance and at the same time
are characterized by good water resistance and good
distributability.
[0020] It was surprising and unforeseeable by the person skilled in
the art that a light protective cosmetic or dermatological
preparation, characterized in that it comprises [0021] (a) PEG-30
dipolyhydroxystearate, [0022] (b) 2-ethylhexyl
2-cyano-3,3-diphenylacrylate, [0023] (c) at least one
dibenzoylmethane derivative and [0024] (d) at least 2% by weight of
titanium dioxide particles (based on the total weight of the
preparation), the preparation being free from water-soluble UV-A
filter substances, would overcome the disadvantages of the prior
art.
[0025] The preparations according to the invention are entirely
satisfactory preparations in every respect which exhibit very good
sensory and cosmetic properties, such as, for example,
distributability on the skin or the ability to absorb into the
skin. They are further characterized by very good light protection
effectiveness, an exceptionally high UV-A protection performance
and by excellent skin compatibility coupled with excellent skin
care data.
[0026] It is particularly surprising and one of the particular
advantages of the present invention that the use of water-soluble
UV-A filters can be totally dispensed with. Further advantages of
the present invention are that, despite a high oil phase fraction
of more than 35% by weight (based on the total weight of the
preparation), no further emulsifier or coemulsifier is necessary
and that in addition the fraction of further stabilizers, such as
waxes, can be chosen to be very low (less than 1.5% by weight,
ideally less than 1% by weight). In this way, despite a high oil
phase, a flowable formulation (with a viscosity of <10 000
mPas--determinable using a Haake viscotester VT-02 at 25.degree.
C.) is obtained and thus good distributability and optimum light
protection are ensured.
[0027] The particularly high UV-A protection is achieved through
the special combination of UV-A filters of a filter liquid at room
temperature (25.degree. C.) (2-ethylhexyl
2-cyano-3,3-diphenylacrylate), a solid lipophilic filter
(dibenzoylmethane derivative) and a pigmentary filter
(TiO.sub.2).
[0028] Particularly advantageous preparations for the purposes of
the present invention comprise more than 3% by weight, in
particular more than 10% by weight--in each case based on the total
weight of the preparation--of UV-A filter substances according to
the invention. It is also advantageous according to the invention
if titanium dioxide has the highest (weight) fraction in the UV-A
filter combination according to the invention.
[0029] The substance combinations according to the invention have a
surprising synergistic effect, i.e. have a superadditive effect
relative to the individual components. They are photostable without
further additives and exhibit a surprisingly high protection
performance in the UV-A region.
[0030] PEG-30 dipolyhydroxystearate is sold by Uniquema under the
trade name ARLACEL.RTM. P135.
[0031] 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate (INCI:
Octocrylene) is available from BASF under the name Uvinul.RTM.N 539
T.
[0032] An advantageous dibenzoylmethane derivative for the purposes
of the present invention is in particular
4-(tert-butyl)-4-methoxydibenzoylmethane (CAS No. 70356-09-1),
which is sold by Givaudan under the trade name Parsol.RTM. 1789 and
by Merck under the trade name Eusolex.RTM. 9020. Also advantageous
is
2,2-methylenebis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)phe-
nol). The dibenzoylmethane derivative or derivatives can be used
advantageously in each case individually or in any combinations
with one another.
[0033] According to the invention, the titanium dioxide particles
may advantageously be surface-treated ("coated"), the intention
being to form or retain, for example, a hydrophilic, amphiphilic or
hydrophobic character. This surface treatment can consist in
providing the pigments with a thin hydrophilic and/or hydrophobic
inorganic and/or organic coating by methods known per se. For the
purposes of the present invention, the various surface coatings may
also comprise water.
[0034] For the purposes of the present invention, the titanium
dioxide particles may also advantageously be used in the form of
commercially obtainable oily or aqueous predispersions. Dispersion
auxiliaries and/or solubility promoters may advantageously be added
to these predispersions.
[0035] Titanium dioxide particles and predispersions of titanium
dioxide particles which are advantageous according to the invention
are obtainable under the following trade names from the companies
listed: TABLE-US-00001 Trade name Coating Manufacturer MT-100TV
Aluminium hydroxide/stearic acid Tayca Corporation MT-100Z
Aluminium hydroxide/stearic acid Tayca Corporation Eusolex
Alumina/simethicone Merck KGaA T-2000 Titanium Octyltrimethylsilane
Degussa dioxide T805 (Uvinul TiO.sub.2) Tioveil AQ Alumina/silica
Solaveil/Uniquema 10PG
[0036] For the purposes of the present invention, the preparations
are preferably in the form of W/O emulsions.
[0037] The cosmetic or dermatological light protection formulations
according to the invention can have the customary composition and
be used for cosmetic or dermatological light protection, and also
for the treatment, care and cleansing of the skin and/or of the
hair and as a make-up product in decorative cosmetics.
[0038] Depending on their formulation, cosmetic or topical
dermatological compositions for the purposes of the present
invention can, for example, be used as skin protection cream,
cleansing milk, day or night cream etc. It is optionally possible
and advantageous to use the compositions according to the invention
as a base for pharmaceutical formulations.
[0039] For use, the cosmetic and dermatological preparations are
applied to the skin and/or the hair in an adequate amount in the
manner customary for cosmetics.
[0040] The cosmetic and dermatological preparations according to
the invention can comprise cosmetic auxiliaries as are customarily
used in such preparations, e.g. preservatives, preservative aids,
complexing agents, bactericides, perfumes, substances for
preventing or increasing foaming, dyes, pigments which have a
colouring action, thickeners, moisturizing and/or humectant
substances, fillers which improve the feel on the skin, fats, oils,
waxes or other customary constituents of a cosmetic or
dermatological formulation, such as alcohols, polyols, polymers,
foam stabilizers, electrolytes, organic solvents or silicone
derivatives.
[0041] Advantageous preservatives for the purposes of the present
invention are, for example, formaldehyde donors (such as, for
example, DMDM hydantoin, which is available, for example, under the
trade name Glydant.TM. from Lonza), iodopropyl butylcarbamates
(e.g. those available under the trade names Glycacil-L, Glycacil-S
from Lonza, and/or Dekaben LMB from Jan Dekker), parabens (i.e.
alkyl p-hydroxybenzoates, such as methyl-, ethyl-, propyl- and/or
butylparaben), phenoxyethanol, ethanol, benzoic acid and the like.
In addition, the preservative system according to the invention
also usually advantageously comprises preservative aids, such as,
for example, octoxyglycerol, glycine soya etc.
[0042] Advantageous complexing agents for the purposes of the
present invention are, for example, EDTA, [S,S]-ethylenediamine
disuccinate (EDDS), which is available, for example, under the
trade name Octaquest from Octel, pentasodium ethylenediamine
tetramethylenephosphonate, which is available, for example, under
the trade name Dequest 2046 from Monsanto and/or iminodisuccinic
acid, which is available, inter alia, from Bayer AG under the trade
names Iminodisuccinate VP OC 370 (about 30% strength solution) and
Baypure CX 100 solid.
[0043] Particularly advantageous preparations are also obtained
when antioxidants are used as additives or active ingredients.
According to the invention, the preparations advantageously
comprise one or more antioxidants. Favourable, but nevertheless
optional, antioxidants which may be used are all antioxidants
customary or suitable for cosmetic and/or dermatological
applications.
[0044] For the purposes of the present invention, water-soluble
antioxidants may be used particularly advantageously, such as, for
example, vitamins, e.g. ascorbic acid and derivatives thereof.
[0045] Preferred antioxidants are also vitamin E and derivatives
thereof, and vitamin A and derivatives thereof.
[0046] The amount of antioxidants (one or more compounds) in the
preparations is preferably 0.001 to 30% by weight, particularly
preferably 0.05 to 20% by weight, in particular 0.1 to 10% by
weight, based on the total weight of the preparation.
[0047] If vitamin E and/or derivatives thereof are the antioxidant
or the antioxidants, it is advantageous to choose their respective
concentrations from the range from 0.001 to 10% by weight, based on
the total weight of the formulation.
[0048] If vitamin A or vitamin A derivatives, or carotenes or
derivatives thereof are the antioxidant or the antioxidants, it is
advantageous to choose their respective concentrations from the
range from 0.001 to 10% by weight, based on the total weight of the
formulation.
[0049] It is particularly advantageous when the cosmetic
preparations according to the present invention comprise cosmetic
or dermatological active ingredients, preferred active ingredients
being antioxidants which can protect the skin against oxidative
stress.
[0050] Further advantageous active ingredients for the purposes of
the present invention are natural active ingredients and/or
derivatives thereof, such as, for example, .alpha.-lipoic acid,
phytoene, D-biotin, coenzyme Q10, .alpha.-glucosylrutin, carnitine,
carnosine, natural and/or synthetic isoflavonoids, creatine,
taurine and/or .beta.-alanine, and 8-hexadecene-1,16-dicarboxylic
acid (dioic acid, CAS number 20701-68-2; provisional INCI name
Octadecenedioic acid).
[0051] Formulations according to the invention which comprise, for
example, known antiwrinkle active ingredients, such as flavone
glycosides (in particular .alpha.-glycosylrutin), coenzyme Q10,
vitamin E and/or derivatives and the like are particularly
advantageously suitable for the prophylaxis and treatment of
cosmetic or dermatological changes in the skin, as arise, for
example, during the skin ageing (such as, for example, dryness,
roughness and formation of dryness wrinkles, itching, reduced
refatting (e.g. after washing), visible vascular dilations
(telangiectases, cuperosis), flaccidity and formation of wrinkles
and lines, local hyperpigmentation, hypopigmentation and incorrect
pigmentation (e.g. age spots), increased susceptibility to
mechanical stress (e.g. cracking) and the like). In addition, they
are advantageously suitable to counter the appearance of dry or
rough skin.
[0052] The water phase of the preparations according to the
invention can advantageously comprise customary cosmetic
auxiliaries, such as, for example, alcohols, in particular those of
low carbon number, preferably ethanol and/or isopropanol, diols or
polyols of low carbon number, and ethers thereof, preferably
propylene glycol, glycerol, butylene glycol, ethylene glycol,
ethylene glycol monoethyl or monobutyl ether, propylene glycol
monomethyl, monoethyl or monobutyl ether, diethylene glycol
monomethyl or monoethyl ether and analogous products, polymers,
foam stabilizers, electrolytes, and in particular one or more
thickeners, which may advantageously be chosen from the group
consisting of silicon dioxide, aluminium silicates or
polysaccharides or derivatives thereof, e.g. hyaluronic acid,
xanthan gum, hydroxypropylmethylcellulose, particularly
advantageously from the group of polyacrylates, preferably a
polyacrylate from the group of so-called Carbopols [from Goodrich],
for example Carbopol grades 980, 981, 1382, 2984, 5984, ETD 2020,
ETD 2050, Ultrez 10, in each case individually or in
combination.
[0053] In addition, the preparations according to the invention can
advantageously also comprise self-tanning substances, such as, for
example, dihydroxyacetone and/or melanin derivatives in
concentrations of from 1% by weight to 8% by weight, based on the
total weight of the preparation.
[0054] In addition, the preparations according to the invention can
advantageously also comprise repellents for protection against
flies, ticks and spiders and the like. For example,
N,N-diethyl-3-methylbenzamide (trade name: Meta-delphene, "DEET"),
dimethyl phthalate (trade name: Palatinol M, DMP) and in particular
ethyl 3-(N-n-butyl-N-acetylamino)propionate (available under the
trade name Insekt Repellent.RTM. 3535 from Merck) are advantageous.
The repellents can either be used individually or in
combination.
[0055] Moisturizers is the term used to refer to substances or
mixtures of substances which impart to cosmetic or dermatological
preparations the property, following application or distribution on
the surface of the skin, of reducing moisture release by the horny
layer (also called trans-epidermal water loss (TEWL)) and/or of
positively influencing hydration of the horny layer.
[0056] Advantageous moisturizers for the purposes of the present
invention are, for example, glycerol, lactic acid and/or lactates,
in particular sodium lactate, butylene glycol, propylene glycol,
biosaccharide gum-1, glycine soya, ethylhexyloxyglycerol,
pyrrolidone-carboxylic acid and urea. In addition, it is
particularly advantageous to use polymeric moisturizers from the
group of water-soluble and/or water-swellable and/or water-gelable
polysaccharides. Hyaluronic acid, chitosan and/or a fucose-rich
polysaccharide, which is filed in the Chemical Abstracts under the
registry number 178463-23-5 and which is available, for example,
under the name Fucogel.RTM. 1000 by SOLABIA S. A., for example, are
particularly advantageous. Moisturizers can advantageously also be
used as anti-wrinkle active ingredients for the prophylaxis and
treatment of cosmetic or dermatological changes in the skin, as
arise, for example, during skin ageing.
[0057] The cosmetic or dermatological preparations according to the
invention can also advantageously, but not necessarily, comprise
fillers, which, for example, further improve the sensory and
cosmetic properties of the formulations and, for example, bring
about or enhance a velvety or silky feel on the skin. Advantageous
fillers for the purposes of the present invention are starch and
starch derivatives (such as, for example, tapioca starch, distarch
phosphate, aluminium or sodium starch octenylsuccinate and the
like), pigments which have neither a primarily UV filter effect nor
a colouring effect (such as, for example, boron nitride etc.)
and/or Aerosils.RTM. (CAS No. 7631-86-9).
[0058] The oil phase of the formulations according to the invention
is advantageously chosen from the group of polar oils, for example
from the group of lecithins and of fatty acid triglycerides, namely
the triglycerol esters of saturated and/or unsaturated, branched
and/or unbranched alkanecarboxylic acids with a chain length of
from 8 to 24, in particular 12 to 18, carbon atoms. The fatty acid
triglycerides can, for example, be chosen advantageously from the
group of synthetic, semisynthetic and natural oils, such as, for
example, cocoglyceride, olive oil, sunflower oil, soya oil, peanut
oil, rapeseed oil, almond oil, palm oil, coconut oil, castor oil,
wheatgerm oil, grapeseed oil, thistle oil, evening primrose oil,
macadamia nut oil and the like.
[0059] Also advantageous according to the invention are, for
example, natural waxes of animal and vegetable origin, such as, for
example, beeswax and other insect waxes, and berry wax, sheabutter
and/or lanolin (woolwax). It is also advantageous to choose wax
components from the group of glycerides, in particular from the
group of triglycerides. For the purposes of the present invention,
C.sub.18-36 triglyceride, which is available under the trade name
Syncrowax HGLC from Croda GmbH, is particularly advantageous.
[0060] Further advantageous polar oil components for the purposes
of the present invention may also be chosen from the group of
esters of saturated and/or unsaturated, branched and/or unbranched
alkanecarboxylic acids of chain length from 3 to 30 carbon atoms
and saturated and/or unsaturated, branched and/or unbranched
alcohols of chain length from 3 to 30 carbon atoms, and from the
group of esters of aromatic carboxylic acids and saturated and/or
unsaturated, branched and/or unbranched alcohols of chain length
from 3 to 30 carbon atoms. Such ester oils can then advantageously
be chosen from the group consisting of octyl palmitate, octyl
cocoate, octyl isostearate, octyldodecyl myristate, octyldodecanol,
cetearyl isononanoate, isopropyl myristate, isopropyl palmitate,
isopropyl stearate, isopropyl oleate, n-butyl stearate, n-hexyl
laurate, n-decyl oleate, isooctyl stearate, isononyl stearate,
isononyl isononanoate, 2-ethylhexyl palmitate, 2-ethylhexyl
laurate, 2-hexyldecyl stearate, 2-octyidodecyl palmitate, stearyl
heptanoate, oleyl oleate, oleyl erucate, erucyl oleate, erucyl
erucate, tridecyl stearate, tridecyl trimellitate, and synthetic,
semisynthetic and natural mixtures of such esters, such as, for
example, jojoba oil.
[0061] In addition, the oil phase can advantageously be chosen from
the group of dialkyl ethers and dialkyl carbonates, advantageous
examples being dicaprylyl ether (Cetiol OE) and/or dicaprylyl
carbonate, for example that available under the trade name Cetiol
CC from Cognis.
[0062] It is also preferred to choose the oil component or oil
components from the group consisting of isoeicosane, neopentyl
glycol diheptanoate, propylene glycol dicaprylate/dicaprate,
caprylic/capric/diglyceryl succinate, butylene glycol
dicaprylate/dicaprate, C.sub.12-13-alkyl lactate,
di-C.sub.12-13-alkyl tartrate, triisostearin, dipentaerythritol
hexacaprylate/hexacaprate, propylene glycol monoisostearate,
tricaprylin, dimethyl isosorbide. It is particularly advantageous
if the oil phase of the formulations according to the invention has
a content of C.sub.12-15-alkyl benzoate or consists entirely of
this.
[0063] Advantageous oil components are also, for example,
butyloctyl salicylate (for example that available under the trade
name Hallbrite BHB from CP Hall), hexadecyl benzoate and butyloctyl
benzoate and mixtures thereof (Hallstar AB) and/or diethylhexyl
naphthalate (Hallbrite TQ or Corapan TQ from H&R).
[0064] Any mixtures of such oil and wax components can also be used
advantageously for the purposes of the present invention.
[0065] In addition, the oil phase can likewise advantageously also
comprise nonpolar oils, for example those which are chosen from the
group of branched and unbranched hydrocarbons and hydrocarbon
waxes, in particular mineral oil, vaseline (petrolatum), paraffin
oil, squalane and squalene, polyolefins, hydrogenated
polyisobutenes and isohexadecane. Among the polyolefins,
polydecenes are the preferred substances.
[0066] The oil phase can also advantageously have a content of
cyclic or linear silicone oils, or consist entirely of such oils,
although it is preferred to use an additional content of other oil
phase components apart from the silicone oil or the silicone
oils.
[0067] Silicone oils are high molecular weight synthetic polymeric
compounds in which silicon atoms are joined via oxygen atoms in a
chain-like and/or reticular manner and the remaining valencies of
the silicon are saturated by hydrocarbon radicals (in most cases
methyl groups, more rarely ethyl, propyl, phenyl groups, etc.).
Systematically, the silicone oils are referred to as
polyorganosiloxanes. The methyl-substituted polyorganosiloxanes,
which represent the most important compounds of this group in terms
of amount and are characterized by the following structural formula
##STR1## are also referred to as polydimethylsiloxane or
Dimethicone (INCI). Dimethicones exist in various chain lengths and
with various molecular weights.
[0068] Particularly advantageous polyorganosiloxanes for the
purposes of the present invention are, for example,
dimethylpolysiloxanes [poly(dimethylsiloxane)], which are
available, for example, under the trade names Abil 10 to 10 000
from Th. Goldschmidt. Also advantageous are
phenylmethylpolysiloxanes (INCI: Phenyl Dimethicone, Phenyl
Trimethicone), cyclic silicones (octamethylcyclotetrasiloxane and
decamethylcyclopenta-siloxane), which are also referred to as
Cyclomethicone in accordance with INCI, amino-modified silicones
(INCI: Amodimethicones) and silicone waxes, e.g.
polysiloxane-polyalkylene copolymers (INCI: Stearyl Dimethicones
and Cetyl Dimethicones) and dialkoxydimethylpolysiloxanes (Stearoxy
Dimethicones and Behenoxy Stearyl Dimethicones), which are
available as various Abil wax grades from Th. Goldschmidt. However,
other silicone oils can also be used advantageously for the
purposes of the present invention, for example cetyldimethicone,
hexamethylcyclotrisiloxane, poly-dimethylsiloxane,
poly(methylphenylsiloxane).
[0069] The preparations according to the invention can also
advantageously comprise one or more substances from the following
group of siloxane elastomers, for example in order to increase the
water resistance and/or the light protection factor of the
products: [0070] (a) siloxane elastomers which contain the units
R.sub.2SiO and RSiO.sub.1.5 and/or R.sub.3SiO.sub.0.5 and/or
SiO.sub.2, [0071] where the individual radicals R, in each case
independently of one another, are hydrogen, C.sub.1-24-alkyl (such
as, for example, methyl, ethyl, propyl) or aryl (such as, for
example, phenyl or tolyl), alkenyl (such as, for example, vinyl),
and the weight ratio of the units R.sub.2SiO to RSiO.sub.1.5 is
chosen from the range from 1:1 to 30:1; [0072] (b) siloxane
elastomers which are insoluble and swellable in silicone oil and
which are obtainable by the addition reaction of an
organopolysiloxane (1) which contains silicon-bonded hydrogen with
an organopolysiloxane (2) which contains unsaturated aliphatic
groups, [0073] where the quantitative amounts used are chosen such
that the amount of hydrogen in the organopolysiloxane (1) or in the
unsaturated aliphatic groups of the organopolysiloxane (2) [0074]
is in the range from 1 to 20 mol % when the organopolysiloxane is
noncyclic and [0075] is in the range from 1 to 50 mol % when the
organopolysiloxane is cyclic.
[0076] For the purposes of the present invention, the siloxane
elastomer or elastomers are advantageously present in the form of
spherical powders or in the form of gels.
[0077] Siloxane elastomers present in the form of spherical powders
which are advantageous according to the invention are those with
the INCI name DimethiconeNinyl Dimethicone Crosspolymer, for
example that available from DOW CORNING under the trade names DOW
CORNING 9506 Powder.
[0078] It is particularly preferred when the siloxane elastomer is
used in combination with oils from hydrocarbons of animal and/or
vegetable origin, synthetic oils, synthetic esters, synthetic
ethers or mixtures thereof.
[0079] It is very particularly preferred when the siloxane
elastomer is used in combination with unbranched silicone oils
which are liquid or pasty at room temperature or cyclic silicone
oils or mixtures thereof. Organopolysiloxane elastomers with the
INCI name Dimethicone/Polysilicone-11, very particularly the
Gransil grades obtainable from Grant Industries Inc. GCM, GCM-5,
DMG-6, CSE gel, PM-gel, LTX, ININ gel, AM-18 gel and/or DMCM-5 are
particularly advantageous.
[0080] It is very extremely preferred when the siloxane elastomer
is used in the form of a gel of siloxane elastomer and a lipid
phase where the content of the siloxane elastomer in the gel is 1
to 80% by weight, preferably 0.1 to 60% by weight, in each case
based on the total weight of the gel.
[0081] It is advantageous for the purposes of the present invention
to choose the total amount of the siloxane elastomers (active
content) from the range from 0.01 to 10% by weight, advantageously
from 0.1 to 5% by weight, in each case based on the total weight of
the formulation.
[0082] The cosmetic and dermatological preparations according to
the invention can comprise dyes and/or colour pigments,
particularly when they are in the form of decorative cosmetics. The
dyes and colour pigments can be chosen from the corresponding
positive list in the Cosmetics Directive or the EC list of cosmetic
colorants. In most cases, they are identical to dyes approved for
foods. Advantageous colour pigments are, for example, titanium
dioxide, mica, iron oxides (e.g. Fe.sub.2O.sub.3, Fe.sub.3O.sub.4,
FeO(OH)) and/or tin oxide. Advantageous dyes are, for example,
carmine, Prussian blue, chromium oxide green, ultramarine blue
and/or manganese violet. It is particularly advantageous to choose
the dyes and/or the colour pigments from the Rowe Colour Index,
3.sup.rd Edition, Society of Dyers and Colourists, Bradford,
England, 1971.
[0083] If the formulations according to the invention are in the
form of products which are used on the face, it is favourable to
choose one or more substances from the following group as the dye:
2,4-dihydroxyazobenzene,
1-(2'-chloro-4'-nitro-1'-phenylazo)-2-hydroxy-naphthalene, Ceres
red, 2-(sulpho-1-naphthylazo)-1-naphthol-4-sulphonic acid, calcium
salt of 2-hydroxy-1,2'-azonaphthalene-1'-sulphonic acid, calcium
and barium salts of
1-(2-sulpho-4-methyl-1-phenylazo)-2-naphthylcarboxylic acid,
calcium salt of
1-(2-sulpho-1-naphthylazo)-2-hydroxynaphthalene-3-carboxylic acid,
aluminium salt of 1-(4-sulpho-1-phenylazo)-2-naphthol-6-sulphonic
acid, aluminium salt of
1-(4-sulpho-1-naphthylazo)-2-naphthol-3,6-disulphonic acid,
1-(4-sulpho-1-naphthylazo)-2-naphthol-6,8-disulphonic acid,
aluminium salt of
4-(4-sulpho-1-phenylazo)-1-(4-sulphophenyl)-5-hydroxypyrazolone-3-
-carboxylic acid, aluminium and zirconium salts of
4,5-dibromofluorescein, aluminium and zirconium salts of
2,4,5,7-tetrabromofluorescein,
3',4',5',6'-tetrachloro-2,4,5,7-tetrabromofluorescein and its
aluminium salt, aluminium salt of 2,4,5,7-tetraiodofluorescein,
aluminium salt of quinophthalonedisulphonic acid, aluminium salt of
indigodisulphonic acid, red and black iron oxide (CIN: 77 491 (red)
and 77 499 (black)), iron oxide hydrate (CIN: 77 492), manganese
ammonium diphosphate and titanium dioxide.
[0084] Also advantageous are oil-soluble natural dyes, such as, for
example, paprika extracts, .beta.-carotene or cochineal.
[0085] Also advantageous for the purposes of the present invention
are formulations with a content of pearlescent pigments. Preference
is given in particular to the types of pearlescent pigments listed
below: [0086] 1. Natural pearlescent pigments, such as, for
example, [0087] "pearlessence" (guanine/hypoxanthin mixed crystals
from fish scales) and [0088] "mother-of-pearl" (ground mussel
shells) [0089] 2. Monocrystalline pearlescent pigments, such as,
for example, bismuth oxychloride (BiOCI) [0090] 3. Layer-substrate
pigments: e.g. mica/metal oxide
[0091] Bases for pearlescent pigments are, for example, pulverulent
pigments or castor oil dispersions of bismuth oxychloride and/or
titanium dioxide, and bismuth oxychloride and/or titanium dioxide
on mica. The lustre pigment listed under CIN 77163, for example, is
particularly advantageous.
[0092] Also advantageous are, for example, the following types of
pearlescent pigments based on mica/metal oxide: TABLE-US-00002
Group Coating/layer thickness Colour Silver-white pearlescent
TiO.sub.2: 40-60 nm Silver pigments Interference pigments
TiO.sub.2: 60-80 nm Yellow TiO.sub.2: 80-100 nm Red TiO.sub.2:
100-140 nm Blue TiO.sub.2: 120-160 nm Green Colour lustre pigments
Fe.sub.2O.sub.3 Bronze Fe.sub.2O.sub.3 Copper Fe.sub.2O.sub.3 Red
Fe.sub.2O.sub.3 Red-violet Fe.sub.2O.sub.3 Red-green
Fe.sub.2O.sub.3 Black Combination pigments
TiO.sub.2/Fe.sub.2O.sub.3 Gold shades TiO.sub.2/Cr.sub.2O.sub.3
Green TiO.sub.2/Prussian blue Deep blue TiO.sub.2/carmine Red
[0093] Particular preference is given, for example, to the
pearlescent pigments obtainable from Merck under the trade names
Timiron, Colourona or Dichrona.
[0094] The list of given pearlescent pigments is not of course
intended to be limiting. Pearlescent pigments which are
advantageous for the purposes of the present invention are
obtainable by numerous methods known per se. For example, other
substrates apart from mica can be coated with further metal oxides,
such as, for example, silica and the like. SiO.sub.2 particles
coated with, for example, TiO.sub.2 and Fe.sub.2O.sub.3
("ronaspheres"), which are sold by Merck and are particularly
suitable for the optical reduction of fine lines, are
advantageous.
[0095] It can, moreover, be advantageous to dispense completely
with a substrate such as mica. Particular preference is given to
iron pearlescent pigments prepared without the use of mica. Such
pigments are obtainable, for example, under the trade name
Sicopearl Kupfer 1000 from BASF.
[0096] In addition, also particularly advantageous are effect
pigments which are obtainable under the trade name Metasomes
Standard/Glifter in various colours (yellow, red, green, blue) from
Flora Tech. The glitter particles are present here in mixtures with
various auxiliaries and dyes (such as, for example, the dyes with
the Colour Index (CI) numbers 19140, 77007, 77289, 77491).
[0097] The dyes and pigments may be present either individually or
in a mixture, and can be mutually coated with one another,
different coating thicknesses generally giving rise to different
colour effects. The total amount of dyes and colour-imparting
pigments is advantageously chosen from the range from, for example,
0.1% by weight to 30% by weight, preferably from 0.5 to 15% by
weight, in particular from 1.0 to 10% by weight, in each case based
on the total weight of the preparations.
[0098] For the purposes of the present invention, it is also
advantageous to provide cosmetic and dermatological preparations
whose main purpose is not protection against sunlight, but which
nevertheless have a content of further UV protection substances.
Thus, for example, UV-A and/or UV-B filter substances are usually
incorporated into daycreams or make-up products. UV protection
substances, like antioxidants and, if desired, preservatives, also
constitute effective protection of the preparations themselves
against spoilage. Also favourable are cosmetic and dermatological
preparations in the form of a sunscreen.
[0099] Accordingly, for the purposes of the present invention, the
preparations can preferably comprise further UV-A, UV-B and/or
broadband filter substances. The formulations can, but do not
necessarily, optionally comprise one or more organic and/or
inorganic pigments as UV filter substances, which may be present in
the water phase and/or the oil phase.
[0100] In addition, the preparations according to the invention can
also advantageously be in the form of so-called oil-free cosmetic
or dermatological emulsions, which comprise a water phase and at
least one UV filter substance which is liquid at room temperature
as a further phase.
[0101] For the purposes of the present invention, particularly
advantageous UV filter substances which are liquid at room
temperature are homomenthyl salicylate (INCI: Homosalate),
2-ethylhexyl 2-hydroxybenzoate (2-ethylhexyl salicylate, octyl
salicylate, INCI: Salicylate) Octyl and esters of cinnamic acid,
preferably 2-ethylhexyl 4-methoxycinnamate (INCI: Octyl
Methoxycinnamate) and isopentyl 4-methoxycinnamate (INCI: Isoamyl
p-Methoxycinnamate),
3-(4-(2,2-bisethoxycarbonylvinyl)phenoxy)propenyl)methoxy-siloxane/dimeth-
ylsiloxane copolymer, which is available, for example, under the
trade name Parsol.RTM. SLX from Hoffmann La Roche.
[0102] Preferred further inorganic pigments are metal oxides and/or
other metal compounds which are insoluble or sparingly soluble in
water, in particular oxides of zinc (ZnO), iron (e.g.
Fe.sub.2O.sub.3), zirconium (ZrO.sub.2), silicon (SiO.sub.2),
manganese (e.g. MnO), aluminium (Al.sub.2O.sub.3), cerium (e.g.
Ce.sub.2O.sub.3), mixed oxides of the corresponding metals, and
mixtures of such oxides, and also the sulphate of barium
(BaSO.sub.4).
[0103] According to the invention, the pigments may advantageously
be surface-treated ("coated"), the intention being to form or
retain, for example, a hydrophilic, amphiphilic or hydrophobic
character. This surface treatment can consist in providing the
pigments with a thin hydrophilic and/or hydrophobic inorganic
and/or organic coat by methods known per se.
[0104] Inorganic surface coatings for the purposes of the present
invention may consist of aluminium oxide (Al.sub.2O.sub.3),
aluminium hydroxide Al(OH).sub.3, or aluminium oxide hydrate (also:
alumina, CAS No.: 1333-84-2), sodium hexametaphosphate
(NaPO.sub.3).sub.6, sodium metaphosphate (NaPO.sub.3).sub.n,
silicon dioxide (SiO.sub.2) (also: silica, CAS No.: 7631-86-9), or
iron oxide (Fe.sub.2O.sub.3). These inorganic surface coatings may
be present on their own, in combination and/or in combination with
organic coating materials.
[0105] Organic surface coatings for the purposes of the present
invention may consist of vegetable or animal aluminium stearate,
vegetable or animal stearic acid, lauric acid, dimethylpolysiloxane
(also: Dimethicone), methylpolysiloxane (Methicone), simethicone (a
mixture of dimethylpolysiloxane with an average chain length of
from 200 to 350 dimethylsiloxane units and silica gel) or alginic
acid. These organic surface coatings may be present on their own,
in combination and/or in combination with inorganic coating
materials.
[0106] Zinc oxide particles and predispersions of zinc oxide
particles which are suitable according to the invention are
obtainable under the following trade names from the companies
listed: TABLE-US-00003 Trade name Coating Manufacturer Z-Cote HP1
2% Dimethicone BASF Z-Cote / BASF ZnO NDM 5% Dimethicone H&R
MZ-303S 3% Methicone Tayca Corporation MZ-505S 5% Methicone Tayca
Corporation
[0107] Further advantageous pigments are latex particles. Latex
particles advantageous according to the invention are those
described in the following specifications: U.S. Pat. No. 5,663,213
and EP 0 761 201. Particularly advantageous latex particles are
those which are formed from water and styrene/acrylate copolymers
and are available, for example, under the trade name "Alliance
SunSphere" from Rohm & Haas.
[0108] Further advantageous UV-A filter substances for the purposes
of the present invention are hydroxybenzophenones which are
characterized by the following structural formula: ##STR2## in
which [0109] R.sup.1 and R.sup.2, independently of one another, are
hydrogen, C.sub.1-C.sub.20-alkyl, C.sub.3-C.sub.10-cycloalkyl or
C.sub.3-C.sub.10-cycloalkenyl, where the substituents R.sup.1 and
R.sup.2, together with the nitrogen atom to which they are bonded,
can form a 5-membered or 6-membered ring and [0110] R.sup.3 is a
C.sub.1-C.sub.20-alkyl radical.
[0111] A particularly advantageous hydroxybenzophenone for the
purposes of the present invention is hexyl
2-(4'-diethylamino-2'-hydroxybenzoyl)benzoate (also:
Aminobenzophenone), which is characterized by the following
structure: ##STR3## and is available under Uvinul A Plus from
BASF.
[0112] Advantageous further UA-B filter substances for the purposes
of the present invention are sulphonated, water-soluble UV filters,
such as, for example: [0113] Salts of
2-phenylbenzimidazole-5-sulphonic acid, such as its sodium,
potassium or its triethanolammonium salt, and the sulphonic acid
itself with the INCI name Phenylbenzimidazole Sulphonic Acid (CAS
No. 27503-81-7), which is available, for example, under the trade
name Eusolex 232 from Merck, or under Neo Heliopan Hydro from
Haarmann & Reimer.
[0114] Advantageous UV filter substances for the purposes of the
present invention are also so-called broadband filters, i.e. filter
substances which absorb both UV-A and also UV-B radiation.
[0115] Advantageous broadband filters or UV-B filter substances
are, for example, triazine derivatives, such as, for example,
[0116] Dioctylbutylamidotriazone (INCI:
Diethylhexylbutamidotriazone), which is available under the trade
name UVASORB HEB from Sigma 3V; [0117] Tris(2-ethylhexyl)
4,4',4''-(1,3,5-triazine-2,4,6-triyltriimino)trisbenzoate, also:
2,4,6-tris[anilino(p-carbo-2'-ethyl-1'-hexyloxy)]-1,3,5-triazine
(INCI: Octyl Triazone), which is sold by BASF Aktiengesellschaft
under the trade name UVINUL.RTM. T 150.
[0118] An advantageous broadband filter for the purposes of the
present invention is also
2,2'-methylenebis(6-(2H-benzotriazol-2-yl)-4-(1,1,3,3-tetramethylbutyl)ph-
enol), which is available under the trade name Tinosorb.RTM. M from
CIBA-Chemikalien GmbH.
[0119] For the purposes of the present invention, an advantageous
broadband filter is also
2-(2H-benzotriazol-2-yl)-4-methyl-6-[2-methyl-3-[1,3,3,3-tetramethyl-1-[(-
trimethyl-silyl)oxy]disiloxanyl]propyl]phenol (CAS No.:
155633-54-8) with the INCI name Drometrizole Trisiloxane.
[0120] The further UV filter substances may be oil-soluble.
Advantageous oil-soluble filter substances are, for example: [0121]
3-benzylidenecamphor derivatives, preferably
3-(4-methylbenzylidene)camphor, 3-benzylidenecamphor; [0122]
4-aminobenzoic acid derivatives, preferably 2-ethylhexyl
4-(dimethylamino)benzoate, amyl 4-(dimethylamino)benzoate; [0123]
esters of benzalmalonic acid, preferably di(2-ethylhexyl)
4-methoxybenzalmalonate; [0124] esters of cinnamic acid, preferably
2-ethylhexyl 4-methoxycinnamate, isopentyl 4-methoxycinnamate.
[0125] derivatives of benzophenone, preferably
2-hydroxy-4-methoxybenzophenone,
2-hydroxy-4-methoxy-4'-methylbenzophenone,
2,2'-dihydroxy-4-methoxy-benzophenone and [0126] UV filters bonded
to polymers.
[0127] The list of given UV filters which can be used for the
purposes of the present invention is not of course intended to be
limiting.
[0128] The preparations according to the invention advantageously
comprise the substances which absorb UV radiation in the UV-A
and/or UV-B region in a total amount of, for example, from 2.0% by
weight to 40% by weight, preferably from 3.0 to 35% by weight, in
particular 5.0 to 30% by weight, in each case based on the total
weight of the preparations, in order to provide cosmetic
preparations which protect the hair and/or the skin from the entire
range of ultraviolet radiation.
[0129] The examples below are intended to illustrate the present
invention without limiting it. The numerical values in the examples
are percentages by weight, based on the total weight of the
particular preparations.
EXAMPLES
[0130] W/O Emulsions TABLE-US-00004 1 2 3 4 5 PEG-30
dipolyhydroxystearate 2.00 4.00 1.00 2.00 1.00 Cetyldimethicone
copolyol 4.00 2.50 3.00 Polyglyceryl-2 dipolyhydroxystearate 3.00
1.00 Isostearyl diglyceryl succinate 0.75 0.30 Lauryl methicone
copolyol 2.00 Polysorbate-65 2.00 1.50 PEG-100 stearate 1.20 0.70
Cetearyl sulphate 0.25 1.00 Dimethicone 4.00 5.00 2.00
Cyclomethicone 10.00 5.00 5.00 3.00 UVASorb .RTM. K2A 0.50 Uvinul
.RTM. A Plus 2.00 4.00 Bisethylhexyloxyphenol
methoxyphenyl-triazine 1.00 0.50 Drometrizole trisiloxane 1.00
Phenylbenzimidazolesulphonic acid 0.50 4-Methylbenzylidenecamphor
4.00 Methylenebisbenzotriazolyltetramethyl-butylphenol 3.00
Ethylhexyl methoxycinnamate 3.00 5.00 10.00
Diethylhexylbutamidotriazone 1.00 6.50 Ethylhexyltriazone 3.00 4.00
Ethylhexyl salicylate 5.00 3.50 Octocrylene 3.00 5.00 1.00 2.00
2.00 Butylmethoxydibenzoylmethane 3.00 2.00 1.50 3.00 4.00 Titanium
dioxide T805 5.00 4.00 2.00 6.00 6.00 Zinc oxide Z-Cote 2.00 1.00
Dicaprylyl carbonate 5.00 15.00 4.00 Isopropyl stearate 5.00 5.00
Butylene glycol dicaprylate/dicaprate 5.00 3.00 Dihexyl carbonate
5.00 C12-15 alkyl benzoate 7.00 10.00 Mineral oil 5.00 6.00 Coconut
fatty acid glyceride 2.00 5.00 PVP hexadecene copolymer 0.75 0.40
Glycerol 5.00 12.50 5.00 15.50 Sorbitol 5.00 10.00
.alpha.-Glucosylrutin 0.15 EDTA 0.15 0.03 0.15 Glycine soya 0.75
1.50 Magnesium sulphate 0.75 1.00 0.45 1.00 DMDM hydantoin 0.05
0.10 Phenoxyethanol 1.00 0.75 0.50 1.00 Alcohol 2.00 5.00 1.00 NaOH
45% 0.40 Dye, oil-soluble 0.02 Perfume 0.30 0.45 0.35 0.15 Water ad
100 ad 100 ad 100 ad 100 ad 100 6 7 8 9 10 11 Cetyldimethicone
copolyol 1.00 PEG-30 dipolyhydroxystearate 4.00 5.00 3.00 5.00 3.00
3.50 Bisethylhexyloxyphenol 3.00 1.50 methoxyphenyltriazine
Butylmethoxydibenzoyl-methane 2.00 3.00 4.00 1.50 1.50 4.00 UVASorb
.RTM. K2A 2.00 Uvinul .RTM. A Plus 1.00 3.00
Phenylbenzimidazole-sulphonic 2.00 acid Ethylhexyl methoxycinnamate
8.00 5.00 4.00 Diethylhexylbutamidotriazone 3.00 1.00 2.00 1.00
3.00 Ethylhexyltriazone 2.00 4.00 Octocrylene 2.00 2.00 3.00 3.00
2.00 2.50 Drometrizole trisiloxane 1.00 Titanium dioxide Uvinul
.RTM. T805 2.00 6.50 6.00 3.50 4.00 Titanium dioxide MT-100 TV 2.00
Zinc oxide Z-Cote .RTM. HP1 3.00 Mineral oil 5.00 5.00 8.00 Coconut
fatty acid glyceride 4.00 6.50 5.00 C12-15 alkyl benzoate 5.00 8.00
9.00 Dicaprylyl ether 10.00 5.00 2.00 7.00 Butylene glycol 3.00
9.00 7.00 8.00 4.00 dicaprylate/dicaprate Cetyl dimethicone 0.50
1.00 0.50 C18-36 fatty acid triglyceride 1.00 0.50 1.0
Cyclomethicone 2.00 3.00 3.00 2.00 Na starch octenyl succinate 0.50
0.50 1.00 PVP eicosene copolymer 0.50 1.50 1.00 Trisodium EDTA 1.00
1.00 0.50 0.35 Ethylhexyloxyglycerol 0.30 0.50 Methylpropanediol
7.50 Glycerol 5.00 7.50 6.00 8.00 7.50 2.50 Butylene glycol 2.50
Glycine soya 1.00 MgSO.sub.4 1.00 0.50 0.30 0.30 0.50 Lactic acid
& sodium salt of 1.00 0.50 0.85 lactic acid Vitamin E 0.50 0.50
1.00 1.00 DMDM hydantoin 0.60 0.20 Methylparaben 0.50 0.15
Phenoxyethanol 0.50 0.40 0.50 0.60 1.00 0.60 Dihydroxyacetone 5.50
Alcohol 3.00 2.00 3.00 1.00 Perfume 0.20 0.20 0.20 0.20 Water ad
100 ad 100 ad 100 ad 100 ad 100 ad 100
* * * * *