U.S. patent application number 11/072512 was filed with the patent office on 2006-02-09 for novel full length cdna.
This patent application is currently assigned to RESEARCH ASSOCIATION FOR BIOTECHNOLOGY. Invention is credited to Yuri Hio, Ryotaro Irie, Shizuko Ishii, Takao Isogai, Yuuko Isono, Yasuhiko Masuho, Kenji Nagahari, Keiichi Nagai, Kaoru Otsuka, Motoyuki Otsuka, Tetsuji Otsuki, Hiroyuki Sato, Naohiko Seki, Tomoyasu Sugiyama, Ichiro Tamechika, Ai Wakamatsu, Jun-ichi Yamamoto, Tsutomu Yoshikawa.
Application Number | 20060029945 11/072512 |
Document ID | / |
Family ID | 19186716 |
Filed Date | 2006-02-09 |
United States Patent
Application |
20060029945 |
Kind Code |
A1 |
Isogai; Takao ; et
al. |
February 9, 2006 |
Novel full length cDNA
Abstract
Novel full-length cDNAs are provided. 1970 cDNA derived from
human have been isolated. The full-length nucleotide sequences of
the cDNA and amino acid sequences encoded by the nucleotide
sequences have been determined. Because the cDNA of the present
invention are full-length and contain the translation start site,
they provide information useful for analyzing the functions of the
polypeptide.
Inventors: |
Isogai; Takao; (Ibaraki,
JP) ; Sugiyama; Tomoyasu; (Tokyo, JP) ;
Otsuki; Tetsuji; (Kisarazu-shi, JP) ; Wakamatsu;
Ai; (Kisarazu-shi, JP) ; Sato; Hiroyuki;
(Toyonaka-shi, JP) ; Ishii; Shizuko;
(Kisarazu-shi, JP) ; Yamamoto; Jun-ichi;
(Kisarazu-shi, JP) ; Isono; Yuuko; (Kisarazu-shi,
JP) ; Hio; Yuri; (Kisarazu-shi, JP) ; Otsuka;
Kaoru; (Honjo-shi, JP) ; Nagai; Keiichi;
(Tokyo, JP) ; Irie; Ryotaro; (Kisarazu-shi,
JP) ; Tamechika; Ichiro; (Hirakata-shi, JP) ;
Seki; Naohiko; (Chiba-shi, JP) ; Yoshikawa;
Tsutomu; (Kisarazu-shi, JP) ; Otsuka; Motoyuki;
(Tokyo, JP) ; Nagahari; Kenji; (Tokyo, JP)
; Masuho; Yasuhiko; (Tokyo, JP) |
Correspondence
Address: |
FOLEY AND LARDNER LLP;SUITE 500
3000 K STREET NW
WASHINGTON
DC
20007
US
|
Assignee: |
RESEARCH ASSOCIATION FOR
BIOTECHNOLOGY
|
Family ID: |
19186716 |
Appl. No.: |
11/072512 |
Filed: |
March 7, 2005 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
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10104047 |
Mar 25, 2002 |
6943241 |
|
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11072512 |
Mar 7, 2005 |
|
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60350978 |
Jan 25, 2002 |
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Current U.S.
Class: |
435/6.16 ;
435/320.1; 435/325; 435/69.1; 530/350; 530/388.1; 536/23.5 |
Current CPC
Class: |
C07K 14/47 20130101 |
Class at
Publication: |
435/006 ;
435/069.1; 435/320.1; 435/325; 530/350; 530/388.1; 536/023.5 |
International
Class: |
C12Q 1/68 20060101
C12Q001/68; C07H 21/04 20060101 C07H021/04; C12P 21/06 20060101
C12P021/06; C07K 14/47 20060101 C07K014/47; C07K 16/18 20060101
C07K016/18 |
Foreign Application Data
Date |
Code |
Application Number |
Nov 5, 2001 |
JP |
2001-379298 |
Claims
1. (canceled)
2. A polypeptide encoded by a polynucleotide selected from the
group consisting of the following (a) to (g): (a) a polynucleotide
comprising a protein-coding region of the nucleotide sequence of
any one of SEQ ID NOs: 1 to 1970: (b) a polynucleotide encoding a
polypeptide comprising the amino acid sequence of any one of SEQ ID
NOs: 1971 to 3940: (c) a polynucleotide comprising a nucleotide
sequence encoding a polypeptide comprising the amino acid sequence
of any one of SEQ ID NOs: 1971 to 3940, wherein in said amino acid
sequence, one or more amino acids have been substituted, deleted,
inserted and/or added, and wherein said nucleotide sequence encodes
a polypeptide functionally equivalent to a polypeptide comprising
the selected amino acid sequence; (d) a polynucleotide hybridizing
to a polynucleotide comprising the nucleotide sequence of any one
of SEQ ID NOs: 1 to 1970, wherein said nucleotide sequence encodes
a polypeptide functionally equivalent to a polypeptide encoded by
the selected nucleotide sequence; (e) a polynucleotide comprising a
nucleotide sequence encoding a partial amino acid sequence of a
polypeptide encoded by the polynucleotide according to any one of
(a) to (d); (f) a polynucleotide comprising a nucleotide sequence
having at least 70% identity to the nucleotide sequence of any one
of SEQ ID NOs: 1 to 1970; and (g) a polynucleotide comprising a
nucleotide sequence having at least 90% identity to the nucleotide
sequence of any one of SEQ ID NOs: 1 to 1970, or a partial peptide
thereof.
3-7. (canceled)
8. A method for producing the polypeptide or the partial peptide of
claim 2, said method comprising the steps of culturing a
transformant carrying a polynucleotide selected from the group
consisting of the following (a) to (g): (a) a polynucleotide
comprising a protein-coding region of the nucleotide sequence of
any one of SEQ ID NOs: 1 to 1970; (b) a polynucleotide encoding a
polypeptide comprising the amino acid sequence of any one of SEQ ID
NOs: 1971 to 3940; (c) a polynucleotide comprising a nucleotide
sequence encoding a polypeptide comprising the amino acid sequence
of any one of SEQ ID NOs: 1971 to 3940, wherein, in said amino acid
sequence, one or more amino acids have been substituted, deleted,
inserted and/or added, and wherein said nucleotide sequence encodes
a polypeptide functionally equivalent to a polypeptide comprising
the selected amino acid sequence; (d) a polynucleotide hybridizing
to a polynucleotide comprising the nucleotide sequence of any one
of SEQ ID NOs: 1 to 1970, wherein said nucleotide sequence encodes
a polypeptide functionally equivalent to a polypeptide encoded by
the selected nucleotide sequence; (e) a polynucleotide comprising a
nucleotide sequence encoding a partial amino acid sequence of a
polypeptide encoded by the polynucleotide according to any one of
(a) to (d); (f) a polynucleotide comprising a nucleotide sequence
having at least 70% identity to the nucleotide sequence of any one
of SEQ ID NOs: 1 to 1970; and (g) a polynucleotide comprising a
nucleotide sequence having at least 90% identity to the nucleotide
sequence of any one of SEQ ID NOs: 1 to 1970, and recovering an
expression product.
9-14. (canceled)
Description
FIELD OF THE INVENTION
[0001] The present invention relates to polynucleotides encoding
novel polypeptides, polypeptides encoded by the polynucleotides,
and new uses of these.
BACKGROUND OF THE INVENTION
[0002] Currently, the sequencing projects, the determination and
analysis of the genomic DNA of various living organisms have been
in progress all over the world. The whole genomic sequences of more
than 40 species of prokaryotes, a lower eukaryote, yeast, a
multicellular eukaryote, C. elegans, and a higher plants,
arabidopsis, etc. are already determined. For human genome,
presumably having 3 billion base pairs, the analysis was advanced
under global cooperative organization, and a draft sequence was
disclosed in 2001. Moreover, all the structures are to be clear and
to be disclosed in 2002-2003. The aim of the determination of
genomic sequence is to reveal the functions of all genes and their
regulation and to understand living organisms as a network of
interactions between genes, proteins, cells or individuals through
deducing the information in a genome, which is a blueprint of the
highly complicated living organisms. To understand living organisms
by utilizing the genomic information from various species is not
only important as an academic subject, but also socially
significant from the viewpoint of industrial application.
[0003] However, determination of genomic sequences itself cannot
identify the functions of all genes. For example, as for yeast,
only the function of approximately half of the 6000 genes, which is
predicted based on the genomic sequence, was able to be deduced. On
the other hand, the human genome has been estimated to contain
about 30,000-40,000 genes. Further, 100,000 or more types of mRNAs
are said to exist when variants produced by alternative splicing
are taken into consideration. Therefore, it is desirable to
establish "a high throughput analysis system of the gene functions"
which allows us to identify rapidly and efficiently the functions
of vast amounts of the genes obtained by the genomic
sequencing.
[0004] Many genes in the eukaryotic genome are split by introns
into multiple exons. Thus, it is difficult to predict correctly the
structure of encoded protein solely based on genomic information.
In contrast, cDNA, which is produced from mRNA that lacks introns,
encodes a protein as a single continuous amino acid sequence and
allows us to identify the primary structure of the protein easily.
In human cDNA research, to date, more than three million ESTs
(Expression Sequence Tags) are publicly available, and the ESTs
presumably cover not less than 80% of all human genes.
[0005] The information of ESTs is utilized for analyzing the
structure of human genome, or for predicting the exon-regions of
genomic sequences or their expression profile. However, many human
ESTs have been derived from proximal regions to the 3'-end of cDNA,
and information around the 5'-end of mRNA is extremely little.
Among human cDNAs, the number of the corresponding mRNAs whose
encoding full-length protein sequences are deduced is approximately
13,000.
[0006] It is possible to identify the transcription start site of
mRNA on the genomic sequence based on the 5'-end sequence of a
full-length cDNA, and to analyze factors involved in the stability
of mRNA that is contained in the cDNA, or in its regulation of
expression at the translation stage. Also, since a full-length cDNA
contains atg codon, the translation start site, in the 5'-region,
it can be translated into a protein in a correct frame. Therefore,
it is possible to produce a large amount of the protein encoded by
the cDNA or to analyze biological activity of the expressed protein
by utilizing an appropriate expression system. Thus, analysis of a
full-length cDNA provides valuable information which complements
the information from genome sequencing. Also, full-length cDNA
clones that can be expressed are extremely valuable in empirical
analysis of gene function and in industrial application.
[0007] Therefore, if a novel human full-length cDNA is isolated, it
can be used for developing medicines for diseases in which the gene
is involved. The protein encoded by the gene can be used as a drug
by itself. Thus, it has great significance to obtain a full-length
cDNA encoding a novel human protein.
[0008] In particular, human secretory proteins or membrane proteins
would be useful by itself as a medicine like tissue plasminogen
activator (TPA), or as a target of medicines like membrane
receptors. In addition, genes for signal transduction-related
proteins (protein kinases, etc.), glycoprotein-related proteins,
transcription-related proteins, etc. are genes whose relationships
to human diseases have been elucidated. Moreover, genes for
disease-related proteins form a gene group rich in genes whose
relationships to human diseases have been elucidated.
[0009] Therefore, it has great significance to isolate novel
full-length cDNA clones of human, only few of which has been
isolated. Especially, isolation of a novel cDNA clone encoding a
secretory protein or membrane protein is desired since the protein
itself would be useful as a medicine, and also the clones
potentially include a gene involved in diseases. In addition, genes
encoding proteins that are involved in signal transduction,
glycoprotein, transcription, or diseases are expected to be useful
as target molecules for therapy, or as medicines themselves. These
genes form a gene group predicted to be strongly involved in
diseases. Thus, identification of the full-length cDNA clones
encoding those proteins has great significance.
SUMMARY OF THE INVENTION
[0010] An objective of the present invention is to provide
polynucleotides encoding novel polypeptides, polypeptides encoded
by the polynucleotides, and novel usages of these.
[0011] The inventors have developed a method for efficiently
cloning, from a cDNA library having very high fullness-ratio, a
human full-length cDNA that is predicted to be a full-length cDNA
clone, where the cDNA library is synthesized by an improved method
(WO 01/04286) of the oligo-capping method (K. Maruyama and S.
Sugano, Gene, 138: 171-174 (1994); Y. Suzuki et al., Gene, 200:
149-156 (1997)). Then, the nucleotide sequences of cDNA clones
whose fullness ratio is high, obtained by this method, were
determined mainly from their 5'-ends, and, if required, from
3'-ends.
[0012] Further, representative clones, which were estimated to be
novel and full-length, among the clones obtained, were analyzed for
their full-length nucleotide sequences. The determined full-length
nucleotide sequences were analyzed by BLAST homology search of the
databases shown below. Because the homology search of the present
invention is carried out based on the information of full-length
cDNAs including the entire coding regions, homology to every part
of a polypeptide can be analyzed. Thus, in the present invention,
the reliability of homology search has been greatly improved.
[0013] [1] Swissprot
(http://www.ebi.ac.uk/ebi_docsSwissProt_db/swisshome.html), [0014]
[2] GenBank (http://www.ncbi.nlm.nih.gov/web/GenBank), [0015] [3]
UniGene (Human) (http://www.ncbi.nlm.nih.gov/UniGene), and [0016]
[4] nr (a protein database, which has been constructed by combining
data of coding sequences (CDS) in nucleotide sequences deposited in
GenBank, and data of SwissProt, PDB
(http://www.rcsb.org/pdb/index.html), PIR
(http://pir.georgetown.edu/pirwww/pirhome.shtml), and PRF
(http://www.prf.or.jp/en/); overlapping sequences have been
removed.)
[0017] Further, the gene expression profiles of cDNA clones whose
full-length nucleotide sequence had been determined were studied by
analyzing the large-scale cDNA database constructed based on the
5'-end nucleotide sequences of cDNAs obtained. In addition to the
analysis for the expression profile by computer, the profiles of
gene expression in living cells were also determined by PCR. The
present inventors revealed the usefulness of the genes of the
present invention based on these analysis results.
[0018] In the present invention, gene functions were revealed by
the analysis of expression profiles in silico based on the
information of full-length nucleotide sequences. The expression
profiles used in the expression frequency analysis were studied
based on the database containing sufficient amount of fragment
sequence data. The expression frequency analysis was carried out by
referring, for these expression profiles, to the full-length
nucleotide sequences of many cDNA clones obtained in the present
invention. Thus, a highly reliable analysis can be achieved by
referring to the full-length nucleotide sequences of a wide variety
of genes for the sufficiently large population for analysis
(expression profiles). Namely, the results of expression frequency
analysis using the full-length sequences of the present invention
more precisely reflect the gene expression frequency in tissues and
cells from which a certain cDNA library was derived. In other
words, the information of full-length cDNA nucleotide sequence of
the present invention made it possible to achieve the highly
reliable expression frequency analysis.
[0019] The full-length cDNA clones of this invention were obtained
by the method comprising the steps of [1] preparing libraries
containing cDNAs with the high fullness ratio by oligo-capping, and
[2] assembling 5'-end sequences and selecting one with the highest
probability of completeness in length in the cluster formed (there
are many clones longer in the 5'-end direction). However, the uses
of primers designed based on the 5'- and 3'-end sequences of
polynucleotides provided by the present invention enable readily
obtaining full-length cDNAs without such a special technique. The
primer, which is designed to be used for obtaining cDNAs capable of
being expressed, is not limited to the 5'- and 3'-end sequences of
polynucleotide.
[0020] Specifically, the present invention relates to a
polynucleotide selected from the group consisting of the following
(a) to (g): [0021] (a) a polynucleotide comprising a protein-coding
region of the nucleotide sequence of any one of SEQ ID NOs shown in
Table 1; [0022] (b) a polynucleotide encoding a polypeptide
comprising the amino acid sequence of any one of SEQ ID NOs shown
in Table 1; [0023] (c) a polynucleotide comprising a nucleotide
sequence encoding a polypeptide comprising the amino acid sequence
of any one of SEQ ID NOs shown in Table 1, wherein, in said amino
acid sequence, one or more amino acids have been substituted,
deleted, inserted, and/or added, and wherein said nucleotide
sequence encodes a polypeptide functionally equivalent to a
polypeptide comprising the selected amino acid sequence; [0024] (d)
a polynucleotide hybridizing under stringent conditions to a
polynucleotide comprising the nucleotide sequence of any one of SEQ
ID NOs shown in Table 1, wherein said nucleotide sequence encodes a
polypeptide functionally equivalent to a polypeptide encoded by the
selected nucleotide sequence; [0025] (e) a polynucleotide
comprising a nucleotide sequence encoding a partial amino acid
sequence of a polypeptide encoded by the polynucleotide according
to any one of (a) to (d); [0026] (f) a polynucleotide comprising a
nucleotide sequence having at least 70% identity to the nucleotide
sequence of (a); and [0027] (g) a polynucleotide comprising a
nucleotide sequence having at least 90% identity to the nucleotide
sequence of (a).
[0028] The present invention also relates to a polypeptide encoded
by the above-mentioned polynucleotide or a partial peptide thereof,
an antibody binding to the polypeptide or the peptide, and a method
for immunologically assaying the polypeptide or the peptide, which
comprises the steps of contacting the polypeptide or the peptide
with the antibody, and observing the binding between the two.
[0029] Furthermore, the present invention features a vector
comprising the above-mentioned polynucleotide, a transformant
carrying the polynucleotide or the vector, a transformant carrying
the polynucleotide or the vector in an expressible manner, and a
method for producing the polypeptide or the peptide, which
comprises the steps of culturing the transformant and recovering an
expression product.
[0030] Another feature of the present invention is an
oligonucleotide comprising at least 15 nucleotides, said
oligonucleotide comprising a nucleotide sequence complementary to
the nucleotide sequence of any one of SEQ ID NOs: 1 to 1970 or to a
complementary strand thereof. This oligonucleotide can be used as a
primer for synthesizing the above-mentioned polynucleotide or used
as a probe for detecting the polynucleotide. The present invention
includes an antisense polynucleotide against the polynucleotide or
a part thereof, and a method for detecting the polynucleotide,
which comprises the following steps of: [0031] a) incubating a
target polynucleotide with the oligonucleotide under hybridizable
conditions, and [0032] b) detecting hybridization of the target
polynucleotide with the oligonucleotide.
[0033] Still another feature of the present invention is a database
of polynucleotides and/or polypeptides, said database comprising
information on at least one of the nucleotide sequences of SEQ ID
NOs: 1 to 1970 and/or on at least one of the amino acid sequences
of SEQ ID NOs: 1971 to 3940.
[0034] Herein, "polynucleotide" is defined as a molecule, such as
DNA and RNA, in which multiple nucleotides are polymerized. There
are no limitations on the number of the polymerized nucleotides. In
case that the polymer contains relatively low number of
nucleotides, it is also described as an "oligonucleotide", which is
included in the "polynucleotide" of the present invention. The
polynucleotide or the oligonucleotide of the present invention can
be a natural or chemically synthesized product. Alternatively, it
can be synthesized using a template polynucleotide by an enzymatic
reaction such as PCR. Furthermore, the polynucleotide of the
present invention may be modified chemically. Moreover, not only a
single-strand polynucleotide but also a double-strand
polynucleotide is included in the present invention. In this
specification, especially in claims, when the polynucleotide is
described merely as "polynucleotide", it means not only a
single-strand polynucleotide but also a double-strand
polynucleotide. When it means double-strand polynucleotide, the
nucleotide sequence of only one chain is indicated. However, based
on the nucleotide sequence of a sense chain, the nucleotide
sequence of the complementary strand thereof is essentially
determined.
[0035] As used herein, an "isolated polynucleotide" is a
polynucleotide the structure of which is not identical to that of
any naturally occurring polynucleotide or to that of any fragment
of a naturally occurring genomic polynucleotide spanning more than
three separate genes. The term therefore includes, for example, (a)
a DNA which has the sequence of part of a naturally occurring
genomic DNA molecule in the genome of the organism in which it
naturally occurs; (b) a polynucleotide incorporated into a vector
or into the genomic DNA of a prokaryote or eukaryote in a manner
such that the resulting molecule is not identical to any naturally
occurring vector or genomic DNA; (c) a separate molecule such as a
cDNA, a genomic fragment, a fragment produced by polymerase chain
reaction (PCR) or a restriction fragment; and (d) a recombinant
nucleotide sequence that is part of a hybrid gene, i.e., a gene
encoding a fusion polypeptide. Specifically excluded from this
definition are polynucleotides of DNA molecules present in mixtures
of different (i) DNA molecules, (ii) transfected cells, or (iii)
cell clones; e.g., as these occur in a DNA library such as a cDNA
or genomic DNA library.
[0036] The term "substantially pure" as used herein in reference to
a given protein or polypeptide means that the protein or
polypeptide is substantially free from other biological
macromolecules. For example, the substantially pure protein or
polypeptide is at least 75%, 80%, 85%, 95%, or 99% pure by dry
weight. Purity can be measured by any appropriate standard method
known in the art, for example, by column chromatography,
polyacrylamide gel electrophoresis, or HPLC analysis.
[0037] All the cDNAs provided by the present invention are
full-length cDNAs. The "full-length cDNA" herein means that the
cDNA contains the ATG codon, which is the start point of
translation therein. The untranslated regions upstream and
downstream of the protein-coding region, both of which are
naturally contained in natural mRNAs, are not indispensable. It is
preferable that the full-length cDNAs of the present invention
contain the stop codon.
BRIEF DESCRIPTION OF THE DRAWINGS
[0038] FIG. 1 shows the restriction map of the vector
pME18SFL3.
DETAILED DESCRIPTION OF THE INVENTION
[0039] All the clones (1970 clones) of the present invention are
novel and encode the full-length polypeptides. Further, all the
clones are cDNAs with the high fullness ratio, which were obtained
by oligo-capping method, and also clones which are not identical to
any of known human mRNAs (namely, novel clones) selected by
searching, for the 5'-end sequences, mRNA sequences with the
annotation of "complete cds" in the GenBank and UniGene databases
by using the BLAST homology search [S. F. Altschul, W. Gish, W.
Miller, E. W. Myers & D. J. Lipman, J. Mol. Biol., 215: 403-410
(1990); W. Gish & D. J. States, Nature Genet., 3: 266-272
(1993)]; they are also clones that were assumed to have higher
fullness ratio among the members in the cluster formed by
assembling. Most of the clones assessed to have high fullness ratio
in the cluster had the nucleotide sequences longer in the 5'-end
direction.
[0040] All the full-length cDNAs of the present invention can be
synthesized by a method such as PCR (Current protocols in Molecular
Biology edit. Ausubel et al. (1987) Publish. John Wiley & Sons
Section 6.1-6.4) using primer sets designed based on the 5'-end and
3'-end sequences or using primer sets of primers designed based on
the 5'-end sequences and a primer of oligo dT sequence
corresponding to poly A sequence. Table 1 contains the clone names
of full-length cDNA of 1970 clones of the present invention, SEQ ID
NOs of the full-length nucleotide sequences, CDS portions deduced
from the full-length nucleotide sequences, and SEQ ID NOs of the
translated amino acids. The positions of CDS are shown according to
the rule of "DDBJ/EMBL/GenBank Feature Table Definition"
(http://www.ncbi.nlm.nih.gov/collab/FT/index.html). The start
position number corresponds to the first letter of "ATG" that is
the nucleotide triplet encoding methionine; the termination
position number corresponds to the third letter of the stop codon.
These are indicated being flanked with the mark " . . . ". However,
with respect to the clones having no stop codon, the termination
position is indicated by the mark ">" according to the above
rule. TABLE-US-00001 TABLE 1 SEQ ID NO. SEQ ID NO. Clone of
nucleotide Position of amino acid name sequence of CDS sequence
ADRGL20020290 1 62 . . . 1669 1971 ADRGL20021910 2 150 . . . 707
1972 ADRGL20022600 3 464 . . . 814 1973 ADRGL20023920 4 375 . . .
1853 1974 ADRGL20026790 5 113 . . . 2371 1975 ADRGL20027530 6 2013
. . . 2372 1976 ADRGL20036380 7 1129 . . . 1557 1977 ADRGL20036840
8 260 . . . 889 1978 ADRGL20040310 9 539 . . . 844 1979
ADRGL20040770 10 817 . . . 1227 1980 ADRGL20046760 11 1108 . . .
1467 1981 ADRGL20047080 12 823 . . . 1134 1982 ADRGL20047770 13
1532 . . . 1897 1983 ADRGL20057560 14 376 . . . 846 1984
ADRGL20059610 15 969 . . . 1961 1985 ADRGL20062330 16 799 . . .
>2117 1986 ADRGL20063770 17 344 . . . 664 1987 ADRGL20066770 18
22 . . . 1416 1988 ADRGL20067320 19 276 . . . 1016 1989
ADRGL20079060 20 63 . . . 1748 1990 ADRGL20095330 21 929 . . . 1516
1991 ASTRO20001910 22 1753 . . . >2216 1992 ASTRO20003720 23
2089 . . . 2586 1993 ASTRO20004820 24 444 . . . 1040 1994
ASTRO20006530 25 2 . . . 1123 1995 ASTRO20009140 26 344 . . . 1714
1996 ASTRO20010010 27 1236 . . . 1727 1997 ASTRO20010290 28 2 . . .
745 1998 ASTRO20012270 29 286 . . . 627 1999 ASTRO20020240 30 12 .
. . 335 2000 ASTRO20020350 31 1384 . . . 1854 2001 ASTRO20022020 32
467 . . . 1093 2002 ASTRO20026320 33 473 . . . 2161 2003
ASTRO20027330 34 481 . . . 1101 2004 ASTRO20038400 35 52 . . . 2025
2005 ASTRO20045840 36 263 . . . 1051 2006 ASTRO20046280 37 140 . .
. 1402 2007 ASTRO20047510 38 1240 . . . 1611 2008 ASTRO20050810 39
171 . . . 1694 2009 ASTRO20052420 40 1166 . . . 2362 2010
ASTRO20053430 41 218 . . . 1885 2011 ASTRO20055530 42 209 . . . 559
2012 ASTRO20055570 43 242 . . . 733 2013 ASTRO20055930 44 343 . . .
1086 2014 ASTRO20058960 45 55 . . . 1215 2015 ASTRO20069200 46 71 .
. . 1237 2016 ASTRO20075150 47 1004 . . . 1795 2017 ASTRO20076660
48 1594 . . . 1968 2018 ASTRO20085080 49 470 . . . 2011 2019
ASTRO20088950 50 346 . . . 1530 2020 ASTRO20089600 51 142 . . .
1125 2021 ASTRO20090680 52 1221 . . . >2631 2022 ASTRO20091180
53 12 . . . 1214 2023 ASTRO20091770 54 10 . . . 318 2024
ASTRO20141740 55 30 . . . 347 2025 BGGI120000670 56 240 . . . 614
2026 BGGI120010750 57 72 . . . >2507 2027 BNGH410000570 58 957 .
. . 2027 2028 BNGH420008150 59 596 . . . 1606 2029 BNGH420014060 60
1072 . . . 1413 2030 BNGH420015760 61 92 . . . 1336 2031
BNGH420021680 62 147 . . . 2093 2032 BNGH420023870 63 301 . . .
1851 2033 BNGH420024870 64 155 . . . 1960 2034 BNGH420035290 65 114
. . . 2126 2035 BNGH420036410 66 1778 . . . 2143 2036 BNGH420040760
67 698 . . . 1162 2037 BNGH420042910 68 191 . . . 721 2038
BNGH420045380 69 721 . . . 1254 2039 BNGH420046790 70 1079 . . .
1429 2040 BNGH420052350 71 787 . . . 1146 2041 BNGH420059680 72 213
. . . 2393 2042 BNGH420061350 73 600 . . . 3131 2043 BNGH420062340
74 294 . . . 641 2044 BNGH420070370 75 567 . . . 2429 2045
BNGH420074600 76 125 . . . 1696 2046 BNGH420075940 77 31 . . . 510
2047 BNGH420077980 78 288 . . . 2147 2048 BNGH420085100 79 243 . .
. 569 2049 BNGH420086030 80 107 . . . >2556 2050 BNGH420087430
81 195 . . . 1835 2051 BRACE10000510 82 642 . . . 1703 2052
BRACE20003310 83 1379 . . . 2893 2053 BRACE20007330 84 339 . . .
2015 2054 BRACE20009050 85 1023 . . . 1493 2055 BRACE20014450 86
161 . . . 1096 2056 BRACE20017790 87 304 . . . 639 2057
BRACE20018810 88 397 . . . 1146 2058 BRACE20025820 89 453 . . . 767
2059 BRACE20038920 90 1122 . . . 1463 2060 BRACE20050870 91 110 . .
. 1987 2061 BRACE20051600 92 443 . . . 895 2062 BRACE20051930 93
173 . . . 901 2063 BRACE20052430 94 825 . . . 1637 2064
BRACE20052530 95 98 . . . 490 2065 BRACE20054080 96 762 . . . 1382
2066 BRACE20054480 97 111 . . . 902 2067 BRACE20054600 98 392 . . .
1276 2068 BRACE20055560 99 136 . . . 735 2069 BRACE20057870 100
1169 . . . 1825 2070 BRACE20059110 101 1452 . . . 1910 2071
BRACE20059810 102 689 . . . 2218 2072 BRACE20061620 103 162 . . .
1163 2073 BRACE20062580 104 1164 . . . 1859 2074 BRACE20063540 105
378 . . . 1670 2075 BRACE20065470 106 427 . . . 1101 2076
BRACE20066360 107 233 . . . 736 2077 BRACE20068710 108 1099 . . .
1440 2078 BRACE20069000 109 1355 . . . 2305 2079 BRACE20069110 110
576 . . . 917 2080 BRACE20069440 111 278 . . . 1504 2081
BRACE20079200 112 928 . . . 1413 2082 BRACE20079370 113 158 . . .
1522 2083 BRACE20097540 114 1474 . . . 2103 2084 BRACE20098860 115
693 . . . 1193 2085 BRACE20099070 116 53 . . . 1441 2086
BRACE20194670 117 11 . . . 616 2087 BRACE20196180 118 35 . . . 916
2088 BRACE20196960 119 1454 . . . 1912 2089 BRACE20200770 120 306 .
. . 683 2090 BRACE20200970 121 426 . . . 764 2091 BRACE20204670 122
760 . . . 2124 2092 BRACE20205840 123 40 . . . 387 2093
BRACE20207420 124 119 . . . 469 2094 BRACE20212450 125 168 . . .
590 2095 BRACE20215410 126 111 . . . 1361 2096 BRACE20216700 127
1403 . . . 1738 2097 BRACE20216950 128 911 . . . 1315 2098
BRACE20219360 129 198 . . . 596 2099 BRAMY10000980 130 254 . . .
616 2100 BRAMY10001730 131 796 . . . 1158 2101 BRAMY20000210 132
134 . . . 445 2102 BRAMY20000250 133 190 . . . 1932 2103
BRAMY20001510 134 129 . . . 917 2104 BRAMY20003540 135 144 . . .
2477 2105 BRAMY20003880 136 191 . . . 808 2106 BRAMY20005080 137
1638 . . . 1958 2107 BRAMY20013670 138 551 . . . 2881 2108
BRAMY20016780 139 273 . . . 1985 2109 BRAMY20020440 140 359 . . .
685 2110 BRAMY20021580 141 67 . . . 555 2111 BRAMY20023390 142 1568
. . . 1939 2112 BRAMY20023640 143 1684 . . . 2280 2113
BRAMY20024790 144 276 . . . 626 2114 BRAMY20027390 145 420 . . .
782 2115 BRAMY20027990 146 529 . . . 1572 2116 BRAMY20028530 147
973 . . . 1278 2117 BRAMY20028620 148 1048 . . . 1434 2118
BRAMY20035380 149 925 . . . 1707 2119 BRAMY20035830 150 219 . . .
977 2120 BRAMY20036530 151 1411 . . . 1761 2121 BRAMY20036810 152
321 . . . 644 2122 BRAMY20038980 153 715 . . . >2057 2123
BRAMY20039290 154 81 . . . 1043 2124 BRAMY20040580 155 374 . . .
769 2125 BRAMY20043520 156 942 . . . 1778 2126 BRAMY20043630 157 25
. . . 1119 2127 BRAMY20044920 158 40 . . . 1947 2128 BRAMY20045210
159 367 . . . 750 2129 BRAMY20045420 160 4 . . . 888 2130
BRAMY20047560 161 220 . . . 726 2131 BRAMY20050640 162 1802 . . .
2635 2132 BRAMY20050940 163 23 . . . 385 2133 BRAMY20051820 164
1411 . . . 2157 2134 BRAMY20052440 165 29 . . . 448 2135
BRAMY20053910 166 11 . . . 358 2136 BRAMY20055760 167 664 . . .
2253 2137 BRAMY20056620 168 46 . . . 726 2138 BRAMY20056840 169 40
. . . 1392 2139 BRAMY20063750 170 535 . . . 2166 2140 BRAMY20072440
171 823 . . . 1620 2141 BRAMY20072870 172 437 . . . 910 2142
BRAMY20073080 173 3 . . . 353 2143 BRAMY20074110 174 314 . . . 838
2144 BRAMY20074860 175 1135 . . . 1524 2145 BRAMY20076100 176 459 .
. . 1019 2146 BRAMY20076130 177 59 . . . 376 2147 BRAMY20076530 178
1010 . . . 1465 2148 BRAMY20083330 179 10 . . . 492 2149
BRAMY20083820 180 625 . . . 1113 2150 BRAMY20089770 181 173 . . .
955 2151 BRAMY20091230 182 818 . . . 1579 2152 BRAMY20093490 183
637 . . . 1080 2153 BRAMY20094890 184 30 . . . 2138 2154
BRAMY20095080 185 239 . . . 613 2155 BRAMY20095570 186 109 . . .
807 2156 BRAMY20096930 187 1381 . . . 1800 2157 BRAMY20100680 188
268 . . . 870 2158 BRAMY20102900 189 200 . . . 760 2159
BRAMY20107980 190 343 . . . 669 2160 BRAMY20111780 191 584 . . .
2209 2161 BRAMY20117670 192 63 . . . 782 2162 BRAMY20118410 193 24
. . . 782 2163 BRAMY20118490 194 39 . . . 791 2164 BRAMY20120170
195 1130 . . . 1459 2165 BRAMY20123400 196 1420 . . . 1755 2166
BRAMY20124970 197 825 . . . 1226 2167 BRAMY20125170 198 157 . . .
579 2168 BRAMY20125360 199 134 . . . 1060 2169 BRAMY20125550 200 29
. . . 1747 2170 BRAMY20126910 201 114 . . . 518 2171 BRAMY20127310
202 1986 . . . 2336 2172 BRAMY20127760 203 317 . . . 691 2173
BRAMY20134050 204 199 . . . 522 2174 BRAMY20135720 205 57 . . . 401
2175 BRAMY20137360 206 976 . . . 2193 2176 BRAMY20139440 207 2 . .
. 1597 2177 BRAMY20139750 208 88 . . . 435 2178 BRAMY20143870 209
1419 . . . 2102 2179 BRAMY20152510 210 296 . . . 1993 2180
BRAMY20155500 211 722 . . . 1069 2181 BRAMY20158550 212 142 . . .
951 2182 BRAMY20159250 213 286 . . . 810 2183 BRAMY20160020 214 143
. . . 919 2184 BRAMY20173480 215 1544 . . . 1906 2185 BRAMY20190550
216 114 . . . 1640 2186 BRAMY20194680 217 1179 . . . 1517 2187
BRAMY20204270 218 218 . . . 844 2188 BRAMY20206340 219 237 . . .
1805 2189 BRAMY20219620 220 1014 . . . 1670 2190 BRAMY20221600 221
168 . . . 992 2191 BRAMY20223010 222 466 . . . 1257 2192
BRAMY20225250 223 368 . . . 673 2193 BRAMY20225320 224 241 . . .
840 2194 BRAMY20227230 225 1327 . . . 2067 2195
BRAMY20227860 226 10 . . . 657 2196 BRAMY20227960 227 1148 . . .
1558 2197 BRAMY20231150 228 199 . . . 1146 2198 BRAMY20234820 229
199 . . . 2079 2199 BRAMY20237190 230 397 . . . 870 2200
BRAMY20238630 231 303 . . . 1331 2201 BRAMY20243120 232 1756 . . .
2451 2202 BRAMY20244490 233 257 . . . 982 2203 BRAMY20245140 234 3
. . . 1295 2204 BRAMY20245350 235 94 . . . 750 2205 BRAMY20245760
236 35 . . . 1375 2206 BRAMY20251210 237 68 . . . 955 2207
BRAMY20251750 238 97 . . . 846 2208 BRAMY20263000 239 216 . . .
1553 2209 BRAMY20267780 240 1194 . . . 1706 2210 BRAMY20269040 241
989 . . . 2071 2211 BRAMY20271140 242 1582 . . . 2238 2212
BRAMY20274510 243 1785 . . . 2138 2213 BRAMY20285650 244 23 . . .
382 2214 BRAMY20287400 245 1 . . . 456 2215 BRAWH20014590 246 125 .
. . 856 2216 BRAWH20020470 247 131 . . . >2130 2217
BRAWH20020600 248 402 . . . 722 2218 BRAWH20021910 249 394 . . .
1803 2219 BRAWH20025490 250 1699 . . . 2106 2220 BRAWH20026010 251
307 . . . 2034 2221 BRAWH20027250 252 942 . . . 1499 2222
BRAWH20030000 253 381 . . . 1286 2223 BRAWH20039640 254 109 . . .
>2281 2224 BRAWH20040680 255 201 . . . 2291 2225 BRAWH20047790
256 290 . . . 631 2226 BRAWH20050740 257 512 . . . >1907 2227
BRAWH20055240 258 1339 . . . 1653 2228 BRAWH20055330 259 1507 . . .
1911 2229 BRAWH20055780 260 354 . . . 953 2230 BRAWH20058120 261
896 . . . 1501 2231 BRAWH20063010 262 1839 . . . 2579 2232
BRAWH20078080 263 161 . . . 745 2233 BRAWH20078620 264 99 . . . 470
2234 BRAWH20080580 265 35 . . . 1000 2235 BRAWH20082550 266 2191 .
. . 2670 2236 BRAWH20082920 267 1579 . . . 2124 2237 BRAWH20093040
268 1202 . . . 1855 2238 BRAWH20093070 269 469 . . . 1569 2239
BRAWH20094900 270 712 . . . 2166 2240 BRAWH20095900 271 247 . . .
2178 2241 BRAWH20173790 272 634 . . . 1428 2242 BRAWH20174330 273
2532 . . . 3272 2243 BRAWH20175230 274 1119 . . . 1451 2244
BRAWH20175340 275 88 . . . 504 2245 BRAWH20176850 276 32 . . . 2203
2246 BRAWH20182670 277 2751 . . . 3059 2247 BRAWH20183170 278 106 .
. . 909 2248 BRAWH20185260 279 204 . . . 1946 2249 BRAWH20185270
280 15 . . . 869 2250 BRAWH20186010 281 886 . . . 1389 2251
BRAWH20188750 282 21 . . . 824 2252 BRAWH20190530 283 410 . . .
1024 2253 BRAWH20190550 284 55 . . . 1533 2254 BRAWH20191980 285
1426 . . . 2172 2255 BRCAN10000760 286 548 . . . 1885 2256
BRCAN10001050 287 388 . . . 828 2257 BRCAN10001680 288 519 . . .
998 2258 BRCAN20001480 289 114 . . . 449 2259 BRCAN20004180 290 8 .
. . 331 2260 BRCAN20005230 291 63 . . . 590 2261 BRCAN20005410 292
52 . . . 1335 2262 BRCOC10000400 293 11 . . . 3664 2263
BRCOC20000470 294 283 . . . 1851 2264 BRCOC20003600 295 163 . . .
1455 2265 BRHIP10000720 296 4 . . . 312 2266 BRHIP10001040 297 76 .
. . 1317 2267 BRHIP20000210 298 7 . . . 378 2268 BRHIP20003590 299
618 . . . 1238 2269 BRHIP20005060 300 756 . . . 1178 2270
BRSSN20001970 301 89 . . . 526 2271 BRSSN20005610 302 174 . . .
>2375 2272 BRSSN20005660 303 2089 . . . >2535 2273
BRSSN20066440 304 248 . . . 1474 2274 BRSSN20074640 305 257 . . .
985 2275 BRSSN20091190 306 1214 . . . 2002 2276 BRSSN20092440 307 4
. . . 396 2277 BRSSN20093890 308 94 . . . 717 2278 CD34C20001750
309 10 . . . 840 2279 CTONG10000090 310 2551 . . . 2991 2280
CTONG20000340 311 856 . . . 1929 2281 CTONG20002790 312 373 . . .
708 2282 CTONG20004110 313 74 . . . 3079 2283 CTONG20004520 314 146
. . . 772 2284 CTONG20007660 315 192 . . . 1448 2285 CTONG20008190
316 1313 . . . 1789 2286 CTONG20008460 317 1034 . . . 1849 2287
CTONG20015240 318 134 . . . 874 2288 CTONG20017490 319 346 . . .
2235 2289 CTONG20020660 320 219 . . . 635 2290 CTONG20020950 321 24
. . . 3257 2291 CTONG20027660 322 103 . . . 942 2292 CTONG20029030
323 102 . . . 2492 2293 CTONG20030280 324 219 . . . 2891 2294
CTONG20031150 325 2175 . . . 2546 2295 CTONG20031890 326 8 . . .
1705 2296 CTONG20032930 327 352 . . . 3102 2297 CTONG20033500 328
1683 . . . 2018 2298 CTONG20033610 329 404 . . . >3203 2299
CTONG20033750 330 95 . . . 1999 2300 CTONG20035240 331 234 . . .
2687 2301 CTONG20036800 332 432 . . . 770 2302 CTONG20036990 333
1568 . . . 2347 2303 CTONG20039370 334 114 . . . 470 2304
CTONG20041150 335 406 . . . 1164 2305 CTONG20041260 336 477 . . .
2276 2306 CTONG20042640 337 6 . . . 2381 2307 CTONG20044230 338
1199 . . . 3205 2308 CTONG20044870 339 17 . . . 2554 2309
CTONG20045500 340 226 . . . 1950 2310 CTONG20046690 341 385 . . .
840 2311 CTONG20049480 342 216 . . . >3268 2312 CTONG20050490
343 428 . . . 859 2313 CTONG20051100 344 48 . . . 419 2314
CTONG20051450 345 1239 . . . 1823 2315 CTONG20052780 346 976 . . .
1656 2316 CTONG20053990 347 2233 . . . >2955 2317 CTONG20055670
348 2306 . . . 2620 2318 CTONG20055850 349 506 . . . 1246 2319
CTONG20056150 350 95 . . . 1150 2320 CTONG20057750 351 2355 . . .
2849 2321 CTONG20057950 352 3061 . . . 3420 2322 CTONG20059130 353
109 . . . 2613 2323 CTONG20060040 354 204 . . . 2630 2324
CTONG20061290 355 226 . . . 819 2325 CTONG20062730 356 307 . . .
687 2326 CTONG20063770 357 108 . . . 3203 2327 CTONG20063930 358
250 . . . 2700 2328 CTONG20065240 359 1983 . . . 2333 2329
CTONG20065680 360 2369 . . . 2797 2330 CTONG20066110 361 122 . . .
1972 2331 CTONG20068360 362 1136 . . . 1876 2332 CTONG20069320 363
843 . . . 1238 2333 CTONG20069420 364 130 . . . 600 2334
CTONG20070090 365 561 . . . 2960 2335 CTONG20070720 366 431 . . .
2677 2336 CTONG20070780 367 2 . . . 2896 2337 CTONG20070910 368 87
. . . 1397 2338 CTONG20071040 369 16 . . . 1551 2339 CTONG20071680
370 189 . . . >2419 2340 CTONG20072930 371 193 . . . 2643 2341
CTONG20073990 372 749 . . . 2428 2342 CTONG20074000 373 81 . . .
3185 2343 CTONG20074170 374 153 . . . 1211 2344 CTONG20074740 375
2754 . . . >3085 2345 CTONG20076230 376 2192 . . . 2560 2346
CTONG20076810 377 909 . . . 2402 2347 CTONG20077760 378 1517 . . .
2170 2348 CTONG20078340 379 100 . . . 2229 2349 CTONG20079590 380
149 . . . 1066 2350 CTONG20080140 381 159 . . . 686 2351
CTONG20081840 382 586 . . . 897 2352 CTONG20083430 383 159 . . .
1325 2353 CTONG20083980 384 106 . . . 1440 2354 CTONG20084020 385
301 . . . 666 2355 CTONG20084660 386 217 . . . 753 2356
CTONG20085210 387 769 . . . 1878 2357 CTONG20133720 388 15 . . .
350 2358 CTONG20165590 389 1721 . . . 2044 2359 CTONG20165750 390
216 . . . 1955 2360 CTONG20166580 391 320 . . . 1612 2361
CTONG20167750 392 159 . . . 461 2362 CTONG20168240 393 491 . . .
856 2363 CTONG20168460 394 569 . . . 871 2364 CTONG20169040 395 139
. . . 894 2365 CTONG20169530 396 1076 . . . 1399 2366 CTONG20170940
397 184 . . . 1569 2367 CTONG20174290 398 96 . . . 1826 2368
CTONG20174440 399 1246 . . . 1623 2369 CTONG20174580 400 1 . . .
1023 2370 CTONG20176040 401 147 . . . 737 2371 CTONG20179390 402
1423 . . . 1881 2372 CTONG20179890 403 335 . . . 2344 2373
CTONG20179980 404 1821 . . . 2210 2374 CTONG20180620 405 1556 . . .
1915 2375 CTONG20180690 406 366 . . . 1442 2376 CTONG20181350 407
1167 . . . 1607 2377 CTONG20183430 408 319 . . . 2706 2378
CTONG20183830 409 393 . . . 2687 2379 CTONG20184130 410 1970 . . .
2536 2380 CTONG20184830 411 323 . . . 1204 2381 CTONG20186140 412
21 . . . 443 2382 CTONG20186290 413 2170 . . . 2811 2383
CTONG20186370 414 156 . . . 1244 2384 CTONG20186520 415 211 . . .
2136 2385 CTONG20186550 416 260 . . . 811 2386 CTONG20188080 417
207 . . . 2774 2387 CTONG20189000 418 174 . . . 1682 2388
CTONG20190290 419 220 . . . 2205 2389 CTONG20190630 420 34 . . .
2082 2390 DFNES20016470 421 288 . . . 851 2391 DFNES20018000 422 40
. . . 1596 2392 DFNES20025500 423 766 . . . 1134 2393 DFNES20028170
424 289 . . . 1734 2394 DFNES20029660 425 356 . . . 2443 2395
DFNES20032550 426 35 . . . 931 2396 DFNES20043710 427 108 . . . 929
2397 DFNES20046840 428 786 . . . 1310 2398 DFNES20055400 429 343 .
. . 1584 2399 DFNES20057660 430 25 . . . 795 2400 DFNES20063460 431
26 . . . 406 2401 DFNES20072990 432 62 . . . 1156 2402
DFNES20073320 433 377 . . . 1735 2403 DFNES20076340 434 167 . . .
898 2404 DFNES20080880 435 11 . . . 1669 2405 DFNES20088810 436 171
. . . 548 2406 DFNES20094820 437 107 . . . 1807 2407 FCBBF10000230
438 104 . . . 3247 2408 FCBBF10002200 439 480 . . . 782 2409
FCBBF10004760 440 578 . . . 1978 2410 FCBBF20018680 441 177 . . .
1724 2411 FCBBF20020440 442 382 . . . 885 2412 FCBBF20021110 443
158 . . . 517 2413 FCBBF20023490 444 64 . . . 1779 2414
FCBBF20028980 445 694 . . . 1014 2415 FCBBF20029280 446 1680 . . .
2021 2416 FCBBF20032930 447 90 . . . 452 2417 FCBBF20033360 448 315
. . . 2369 2418 FCBBF20035430 449 196 . . . 726 2419 FCBBF20035490
450 131 . . . 1387 2420 FCBBF20036360 451 16 . . . 366 2421
FCBBF20038230 452 1468 . . . 1908 2422 FCBBF20038950 453 648 . . .
992 2423 FCBBF20041380 454 612 . . . 2174 2424 FCBBF20043730 455 45
. . . >2063 2425 FCBBF20054390 456 1367 . . . 1756 2426
FCBBF20056580 457 82 . . . >2394 2427 FCBBF20059660 458 672 . .
. 1226 2428 FCBBF20061310 459 1582 . . . 1980 2429 FCBBF20066340
460 116 . . . 1024 2430 FCBBF20070800 461 968 . . . 1447 2431
FCBBF20070950 462 50 . . . >2299 2432 FCBBF30000010 463 74 . . .
643 2433 FCBBF30001020 464 16 . . . 348 2434 FCBBF30001100 465 341
. . . >3125 2435 FCBBF30001150 466 1209 . . . 1631 2436
FCBBF30002270 467 319 . . . 927 2437 FCBBF30002280 468 113 . . .
4036 2438 FCBBF30002330 469 6 . . . 611 2439 FCBBF30003610 470 1015
. . . 2019 2440 FCBBF30004340 471 120 . . . 1013 2441 FCBBF30004730
472 368 . . . 1027 2442 FCBBF30005180 473 155 . . . 2734 2443
FCBBF30005360 474 29 . . . 2710 2444 FCBBF30005500 475 251 . . .
2494 2445 FCBBF30019140 476 40 . . . 2979 2446
FCBBF30019180 477 140 . . . 1669 2447 FCBBF30019240 478 1214 . . .
2269 2448 FCBBF30021900 479 63 . . . 1973 2449 FCBBF30022680 480
1308 . . . 2480 2450 FCBBF30026580 481 170 . . . 2725 2451
FCBBF30029250 482 52 . . . 4086 2452 FCBBF30035570 483 217 . . .
>2468 2453 FCBBF30042610 484 33 . . . 1244 2454 FCBBF30048420
485 144 . . . 1094 2455 FCBBF30053300 486 62 . . . 2182 2456
FCBBF30056980 487 1098 . . . 1415 2457 FCBBF30062490 488 128 . . .
1063 2458 FCBBF30063990 489 250 . . . 828 2459 FCBBF30068210 490 51
. . . 2762 2460 FCBBF30071500 491 227 . . . >2898 2461
FCBBF30072440 492 2485 . . . 2865 2462 FCBBF30072480 493 2602 . . .
>3057 2463 FCBBF30074530 494 1031 . . . 1432 2464 FCBBF30074620
495 840 . . . 1316 2465 FCBBF30075970 496 146 . . . 460 2466
FCBBF30076310 497 42 . . . 1007 2467 FCBBF30078600 498 113 . . .
1399 2468 FCBBF30079770 499 693 . . . 2777 2469 FCBBF30080730 500
54 . . . 467 2470 FCBBF30081000 501 526 . . . 924 2471
FCBBF30085560 502 60 . . . 1919 2472 FCBBF30088700 503 39 . . .
>3015 2473 FCBBF30089380 504 8 . . . 2701 2474 FCBBF30091010 505
172 . . . >3465 2475 FCBBF30091520 506 56 . . . 2284 2476
FCBBF30093170 507 974 . . . 1528 2477 FCBBF30095410 508 64 . . .
1002 2478 FCBBF30099490 509 2939 . . . 3256 2479 FCBBF30100080 510
1237 . . . 1656 2480 FCBBF30100120 511 8 . . . 2305 2481
FCBBF30100410 512 121 . . . 1374 2482 FCBBF30101240 513 1696 . . .
2382 2483 FCBBF30101300 514 3802 . . . >4413 2484 FCBBF30105080
515 973 . . . 1836 2485 FCBBF30105440 516 1354 . . . 2040 2486
FCBBF30105860 517 355 . . . >2524 2487 FCBBF30106950 518 192 . .
. 944 2488 FCBBF30107290 519 1002 . . . 1610 2489 FCBBF30107330 520
703 . . . 1071 2490 FCBBF30114180 521 1777 . . . 2289 2491
FCBBF30114850 522 769 . . . 1503 2492 FCBBF30115230 523 417 . . .
755 2493 FCBBF30115920 524 543 . . . 1802 2494 FCBBF30118670 525
891 . . . 2807 2495 FCBBF30118890 526 184 . . . >2630 2496
FCBBF30125460 527 67 . . . 1926 2497 FCBBF30125880 528 185 . . .
670 2498 FCBBF30128420 529 1789 . . . 2130 2499 FCBBF30129010 530
184 . . . 1236 2500 FCBBF30130410 531 1149 . . . 1874 2501
FCBBF30130580 532 156 . . . 2123 2502 FCBBF30132050 533 718 . . .
1854 2503 FCBBF30132660 534 86 . . . 1051 2504 FCBBF30135890 535
214 . . . >2483 2505 FCBBF30136230 536 24 . . . 3338 2506
FCBBF30138000 537 646 . . . 2901 2507 FCBBF30142290 538 679 . . .
1662 2508 FCBBF30143550 539 111 . . . 3191 2509 FCBBF30145670 540
1533 . . . 1880 2510 FCBBF30151190 541 974 . . . 1312 2511
FCBBF30153170 542 16 . . . 2307 2512 FCBBF30157270 543 84 . . .
>3303 2513 FCBBF30161780 544 21 . . . 659 2514 FCBBF30164510 545
561 . . . 3035 2515 FCBBF30166220 546 178 . . . 483 2516
FCBBF30169280 547 116 . . . 901 2517 FCBBF30169870 548 102 . . .
407 2518 FCBBF30170710 549 8 . . . 382 2519 FCBBF30171230 550 1735
. . . 2361 2520 FCBBF30172330 551 2497 . . . 2952 2521
FCBBF30173960 552 106 . . . >3530 2522 FCBBF30175350 553 2 . . .
721 2523 FCBBF30177290 554 378 . . . 923 2524 FCBBF30179180 555
2382 . . . >3452 2525 FCBBF30179740 556 299 . . . 721 2526
FCBBF30181730 557 43 . . . 351 2527 FCBBF30194370 558 698 . . .
1057 2528 FCBBF30194550 559 9 . . . 1982 2529 FCBBF30195690 560 15
. . . 1682 2530 FCBBF30195700 561 14 . . . 376 2531 FCBBF30197840
562 406 . . . 3015 2532 FCBBF30198670 563 421 . . . 2733 2533
FCBBF30201630 564 1407 . . . 2561 2534 FCBBF30212210 565 1669 . . .
2502 2535 FCBBF30215240 566 774 . . . 1586 2536 FCBBF30220050 567
1431 . . . 2006 2537 FCBBF30222910 568 117 . . . 614 2538
FCBBF30223110 569 647 . . . 1129 2539 FCBBF30223210 570 141 . . .
680 2540 FCBBF30225930 571 166 . . . 1956 2541 FCBBF30228940 572 79
. . . 453 2542 FCBBF30230610 573 99 . . . 440 2543 FCBBF30236670
574 1889 . . . 2719 2544 FCBBF30250980 575 214 . . . 2514 2545
FCBBF30255680 576 27 . . . >2480 2546 FCBBF30257370 577 2 . . .
1873 2547 FCBBF30259050 578 104 . . . 1600 2548 FCBBF30260210 579
115 . . . >2494 2549 FCBBF30260480 580 28 . . . 519 2550
FCBBF30263080 581 535 . . . 900 2551 FCBBF30266510 582 445 . . .
3378 2552 FCBBF30271990 583 187 . . . 1704 2553 FCBBF30275590 584
51 . . . >2374 2554 FCBBF30282020 585 123 . . . 1721 2555
FCBBF30285930 586 260 . . . 697 2556 FCBBF30287940 587 1636 . . .
2079 2557 FCBBF40000610 588 586 . . . 1131 2558 FCBBF40001920 589
753 . . . 1082 2559 FCBBF40005000 590 57 . . . 446 2560
FCBBF50000410 591 930 . . . 1256 2561 FCBBF50000610 592 383 . . .
697 2562 FCBBF50001650 593 562 . . . 1815 2563 FCBBF50003530 594
127 . . . 921 2564 FCBBF50004950 595 2156 . . . 2545 2565
FEBRA20005040 596 295 . . . 2100 2566 FEBRA20007820 597 160 . . .
690 2567 FEBRA20018670 598 184 . . . 1077 2568 FEBRA20026820 599
103 . . . 1836 2569 FEBRA20027070 600 663 . . . 1736 2570
FEBRA20029620 601 565 . . . 1206 2571 FEBRA20031000 602 380 . . .
2551 2572 FEBRA20031150 603 2925 . . . 3293 2573 FEBRA20031280 604
362 . . . 3124 2574 FEBRA20031810 605 1093 . . . 1455 2575
FEBRA20035200 606 2607 . . . 3215 2576 FEBRA20035240 607 74 . . .
826 2577 FEBRA20038220 608 157 . . . 1305 2578 FEBRA20038330 609
1612 . . . 2253 2579 FEBRA20038970 610 1279 . . . 2811 2580
FEBRA20039070 611 967 . . . 1575 2581 FEBRA20039260 612 23 . . .
685 2582 FEBRA20040230 613 1663 . . . 2076 2583 FEBRA20040260 614
244 . . . 561 2584 FEBRA20040290 615 1488 . . . 2330 2585
FEBRA20040560 616 711 . . . 1496 2586 FEBRA20045380 617 81 . . .
398 2587 FEBRA20046200 618 125 . . . 2062 2588 FEBRA20046280 619
694 . . . 1017 2589 FEBRA20046510 620 859 . . . 2256 2590
FEBRA20057010 621 757 . . . 1107 2591 FEBRA20063720 622 118 . . .
1878 2592 FEBRA20076200 623 303 . . . 680 2593 FEBRA20078180 624
1517 . . . 1888 2594 FEBRA20078800 625 24 . . . 644 2595
FEBRA20080860 626 584 . . . 2419 2596 FEBRA20082660 627 114 . . .
1793 2597 FEBRA20083410 628 1169 . . . 1561 2598 FEBRA20084750 629
888 . . . 1202 2599 FEBRA20086600 630 670 . . . 1407 2600
FEBRA20087550 631 1140 . . . 1814 2601 FEBRA20088610 632 315 . . .
818 2602 FEBRA20088810 633 1302 . . . 2021 2603 FEBRA20090160 634 1
. . . 732 2604 FEBRA20090220 635 106 . . . 2271 2605 FEBRA20091620
636 1528 . . . 1935 2606 FEBRA20092760 637 694 . . . 1317 2607
FEBRA20093270 638 2205 . . . 2507 2608 FEBRA20093280 639 2165 . . .
2485 2609 FEBRA20095410 640 267 . . . 647 2610 FEBRA20098040 641 43
. . . 459 2611 FEBRA20099860 642 55 . . . 573 2612 FEBRA20101410
643 396 . . . 740 2613 FEBRA20108020 644 181 . . . 492 2614
FEBRA20108580 645 542 . . . 901 2615 FEBRA20115930 646 58 . . .
1494 2616 FEBRA20116650 647 178 . . . 573 2617 FEBRA20121200 648
972 . . . 1490 2618 FEBRA20121950 649 1217 . . . 1723 2619
FEBRA20141980 650 644 . . . 955 2620 FEBRA20150420 651 314 . . .
3124 2621 FEBRA20151750 652 52 . . . >2299 2622 FEBRA20163980
653 93 . . . 1223 2623 FEBRA20170240 654 385 . . . 1632 2624
FEBRA20172230 655 377 . . . 1363 2625 FEBRA20173330 656 462 . . .
2378 2626 FEBRA20175020 657 2040 . . . 2438 2627 FEBRA20175330 658
62 . . . 520 2628 FEBRA20177800 659 1918 . . . 2289 2629
FEBRA20180510 660 350 . . . 889 2630 FEBRA20182030 661 341 . . .
745 2631 FEBRA20187460 662 395 . . . 736 2632 FEBRA20191720 663 417
. . . 836 2633 HCHON10000150 664 197 . . . 670 2634 HCHON10001660
665 913 . . . 1338 2635 HCHON20000870 666 442 . . . 1857 2636
HCHON20002650 667 4 . . . 792 2637 HCHON20002710 668 169 . . . 1437
2638 HCHON20015050 669 529 . . . 1995 2639 HEART10001420 670 4 . .
. 1476 2640 HEART10001490 671 159 . . . 1121 2641 HEART20009590 672
1369 . . . 1938 2642 HEART20019310 673 47 . . . 1693 2643
HEART20022200 674 11 . . . 1378 2644 HEART20031680 675 1033 . . .
3018 2645 HEART20047640 676 595 . . . 2904 2646 HEART20063100 677
131 . . . 826 2647 HEART20082570 678 18 . . . 1022 2648
HHDPC10001140 679 506 . . . 1102 2649 HHDPC20051850 680 21 . . .
422 2650 HHDPC20081230 681 132 . . . 2195 2651 HHDPC20082790 682
150 . . . 608 2652 HHDPC20082970 683 1445 . . . 1771 2653
HHDPC20088160 684 214 . . . >2639 2654 HLUNG20008460 685 157 . .
. 1818 2655 HLUNG20009260 686 1035 . . . 1856 2656 HLUNG20009550
687 16 . . . 657 2657 HLUNG20010130 688 1083 . . . 1400 2658
HLUNG20011260 689 135 . . . 479 2659 HLUNG20011440 690 803 . . .
1207 2660 HLUNG20011460 691 43 . . . 1587 2661 HLUNG20012140 692
188 . . . 508 2662 HLUNG20014590 693 1015 . . . >2241 2663
HLUNG20015070 694 377 . . . 1945 2664 HLUNG20015180 695 468 . . .
1808 2665 HLUNG20020500 696 1232 . . . 1687 2666 HLUNG20020850 697
802 . . . 1179 2667 HLUNG20021450 698 753 . . . 1109 2668
HLUNG20023030 699 2466 . . . 2855 2669 HLUNG20024050 700 651 . . .
1568 2670 HLUNG20025620 701 1424 . . . 1765 2671 HLUNG20028110 702
164 . . . 1996 2672 HLUNG20029420 703 160 . . . 774 2673
HLUNG20029490 704 135 . . . 563 2674 HLUNG20030420 705 116 . . .
1906 2675 HLUNG20030490 706 553 . . . 1608 2676 HLUNG20030610 707
920 . . . 1465 2677 HLUNG20031620 708 604 . . . 1038 2678
HLUNG20032460 709 29 . . . 1582 2679 HLUNG20033060 710 1085 . . .
>2287 2680 HLUNG20033310 711 1319 . . . 1654 2681 HLUNG20033350
712 1035 . . . >2205 2682 HLUNG20034970 713 1046 . . . 1747 2683
HLUNG20037140 714 1342 . . . 1698 2684 HLUNG20037160 715 1704 . . .
3152 2685 HLUNG20037780 716 1190 . . . 1855 2686 HLUNG20038330 717
433 . . . 1284 2687 HLUNG20041540 718 199 . . . 1542 2688
HLUNG20041590 719 130 . . . >2341 2689 HLUNG20042730 720 150 . .
. 1484 2690 HLUNG20045340 721 189 . . . 608 2691 HLUNG20047070 722
1310 . . . 1672 2692 HLUNG20050760 723 1813 . . . 2118 2693
HLUNG20051330 724 55 . . . >2821 2694 HLUNG20052300 725 88 . . .
1008 2695 HLUNG20054790 726 1418 . . . 2548 2696 HLUNG20055240 727
204 . . . 554 2697
HLUNG20056560 728 6 . . . 512 2698 HLUNG20057380 729 303 . . . 788
2699 HLUNG20059240 730 1529 . . . 1870 2700 HLUNG20060670 731 753 .
. . 1517 2701 HLUNG20063700 732 1356 . . . 1685 2702 HLUNG20065700
733 90 . . . 911 2703 HLUNG20065990 734 344 . . . 1231 2704
HLUNG20067810 735 178 . . . 639 2705 HLUNG20068120 736 853 . . .
1281 2706 HLUNG20069350 737 198 . . . 1871 2707 HLUNG20070410 738
474 . . . 929 2708 HLUNG20072100 739 164 . . . 1879 2709
HLUNG20072190 740 1394 . . . 1723 2710 HLUNG20072450 741 127 . . .
468 2711 HLUNG20074330 742 1621 . . . >1976 2712 HLUNG20079310
743 1484 . . . 2050 2713 HLUNG20081390 744 123 . . . 1910 2714
HLUNG20081530 745 1218 . . . 1889 2715 HLUNG20082350 746 313 . . .
2109 2716 HLUNG20083330 747 770 . . . 1138 2717 HLUNG20083480 748
183 . . . 1895 2718 HLUNG20083840 749 1389 . . . 1811 2719
HLUNG20083960 750 1214 . . . 1630 2720 HLUNG20084790 751 1185 . . .
1745 2721 HLUNG20085210 752 138 . . . 779 2722 HLUNG20088750 753
1321 . . . 1635 2723 HLUNG20092530 754 224 . . . 577 2724
HLUNG20093030 755 1836 . . . 2246 2725 HLUNG20094130 756 2129 . . .
2554 2726 KIDNE20011600 757 197 . . . 601 2727 KIDNE20016360 758 81
. . . 2798 2728 KIDNE20024380 759 1017 . . . >1994 2729
KIDNE20027980 760 329 . . . 1891 2730 KIDNE20080690 761 1 . . .
1500 2731 KIDNE20081170 762 1356 . . . 2444 2732 KIDNE20083150 763
863 . . . 1342 2733 KIDNE20083620 764 216 . . . 1142 2734
KIDNE20084030 765 28 . . . 1572 2735 KIDNE20084040 766 318 . . .
926 2736 KIDNE20084730 767 580 . . . 2511 2737 KIDNE20084800 768 9
. . . 332 2738 KIDNE20086490 769 162 . . . 1919 2739 KIDNE20086660
770 341 . . . 700 2740 KIDNE20086970 771 202 . . . 846 2741
KIDNE20087880 772 668 . . . 1003 2742 KIDNE20088240 773 101 . . .
1135 2743 KIDNE20089870 774 212 . . . 1621 2744 KIDNE20091090 775
272 . . . 670 2745 KIDNE20094260 776 125 . . . 442 2746
KIDNE20094670 777 997 . . . 2232 2747 KIDNE20095530 778 1573 . . .
>1878 2748 KIDNE20133460 779 210 . . . >1556 2749
KIDNE20133880 780 743 . . . 1057 2750 KIDNE20134130 781 174 . . .
797 2751 KIDNE20134890 782 384 . . . 923 2752 KIDNE20137310 783 304
. . . 876 2753 KIDNE20138450 784 499 . . . 828 2754 KIDNE20140870
785 750 . . . >3206 2755 KIDNE20141120 786 1387 . . . 1932 2756
KIDNE20141700 787 1825 . . . 2286 2757 KIDNE20142680 788 796 . . .
1239 2758 KIDNE20142900 789 45 . . . 764 2759 KIDNE20143200 790 982
. . . 1452 2760 KIDNE20147170 791 1017 . . . 1493 2761
KIDNE20148080 792 1097 . . . 1675 2762 KIDNE20149780 793 267 . . .
1370 2763 KIDNE20150730 794 1671 . . . 1991 2764 KIDNE20152440 795
3 . . . 1346 2765 KIDNE20154330 796 422 . . . 2713 2766
KIDNE20154830 797 1588 . . . 1923 2767 KIDNE20155980 798 1164 . . .
1595 2768 KIDNE20157100 799 90 . . . 1286 2769 KIDNE20160360 800
413 . . . 2692 2770 KIDNE20160960 801 10 . . . 534 2771
KIDNE20163710 802 1605 . . . 1973 2772 KIDNE20165390 803 68 . . .
2341 2773 KIDNE20169180 804 125 . . . 2146 2774 KIDNE20170400 805
597 . . . 2192 2775 KIDNE20173150 806 51 . . . 1052 2776
KIDNE20173430 807 136 . . . 1296 2777 KIDNE20176030 808 2418 . . .
2879 2778 KIDNE20181670 809 180 . . . 659 2779 KIDNE20182540 810
135 . . . 1745 2780 KIDNE20186170 811 83 . . . 748 2781
KIDNE20188630 812 519 . . . 926 2782 KIDNE20189890 813 1834 . . .
2445 2783 KIDNE20189960 814 284 . . . 1666 2784 KIDNE20191870 815
860 . . . 1372 2785 LIVER20006260 816 379 . . . 1668 2786
LIVER20007690 817 329 . . . 760 2787 LIVER20007750 818 176 . . .
1549 2788 LIVER20010510 819 757 . . . 1143 2789 LIVER20010760 820
95 . . . 838 2790 LIVER20010990 821 305 . . . 1009 2791
LIVER20011640 822 1187 . . . 2086 2792 LIVER20013890 823 1528 . . .
2199 2793 LIVER20026440 824 1019 . . . 1963 2794 LIVER20030650 825
1469 . . . 2239 2795 LIVER20032340 826 2181 . . . 2504 2796
LIVER20038000 827 78 . . . 1004 2797 LIVER20040740 828 195 . . .
1370 2798 LIVER20055270 829 148 . . . 1347 2799 MESAN20006200 830
2690 . . . 3235 2800 MESAN20007110 831 1401 . . . 1823 2801
MESAN20008150 832 136 . . . 3567 2802 MESAN20008940 833 122 . . .
514 2803 MESAN20009090 834 247 . . . 1992 2804 MESAN20016270 835
346 . . . 2031 2805 MESAN20021130 836 1540 . . . 2676 2806
MESAN20021220 837 94 . . . 2322 2807 MESAN20021470 838 658 . . .
1446 2808 MESAN20021860 839 217 . . . 1113 2809 MESAN20026870 840
63 . . . 2450 2810 MESAN20027240 841 39 . . . 1940 2811
MESAN20027900 842 212 . . . 3322 2812 MESAN20029780 843 1900 . . .
2331 2813 MESAN20030350 844 142 . . . >2239 2814 MESAN20030370
845 735 . . . 2462 2815 MESAN20030390 846 3 . . . 389 2816
MESAN20033220 847 68 . . . 478 2817 MESAN20034440 848 42 . . . 2183
2818 MESAN20038520 849 31 . . . 2547 2819 MESAN20041380 850 7 . . .
342 2820 MESAN20045750 851 145 . . . 1002 2821 MESAN20056890 852
187 . . . 1125 2822 MESAN20057240 853 101 . . . 778 2823
MESAN20058110 854 174 . . . 1022 2824 MESAN20059570 855 280 . . .
1782 2825 MESAN20060220 856 464 . . . 775 2826 MESAN20060430 857
1589 . . . 3469 2827 MESAN20065990 858 213 . . . 533 2828
MESAN20067430 859 1287 . . . 1973 2829 MESAN20069530 860 336 . . .
>3472 2830 MESAN20084150 861 78 . . . 665 2831 MESAN20085360 862
1168 . . . 1656 2832 MESAN20089260 863 169 . . . 1254 2833
MESAN20090190 864 256 . . . 2898 2834 MESAN20094180 865 1696 . . .
2139 2835 MESAN20095220 866 1118 . . . 1972 2836 MESAN20095800 867
31 . . . 1137 2837 NESOP20004520 868 109 . . . 1512 2838
NESOP20005040 869 316 . . . 1308 2839 NT2NE20018740 870 1413 . . .
1772 2840 NT2NE20018890 871 39 . . . 1061 2841 NT2NE20021860 872
268 . . . 1653 2842 NT2NE20026200 873 1888 . . . 2907 2843
NT2NE20026510 874 338 . . . 1381 2844 NT2NE20028700 875 166 . . .
1377 2845 NT2NE20033150 876 496 . . . 912 2846 NT2NE20037050 877 19
. . . 411 2847 NT2NE20038870 878 190 . . . 1548 2848 NT2NE20039210
879 226 . . . 639 2849 NT2NE20042550 880 708 . . . 1568 2850
NT2NE20045190 881 33 . . . 599 2851 NT2NE20047870 882 314 . . .
1207 2852 NT2NE20053230 883 622 . . . 1068 2853 NT2NE20053950 884
133 . . . 993 2854 NT2NE20059210 885 35 . . . 391 2855
NT2NE20059680 886 120 . . . 443 2856 NT2NE20060750 887 239 . . .
928 2857 NT2NE20061030 888 160 . . . 600 2858 NT2NE20062880 889 201
. . . 539 2859 NT2NE20064780 890 284 . . . 1771 2860 NT2NE20066590
891 821 . . . 1204 2861 NT2NE20069580 892 1404 . . . 2282 2862
NT2NE20070520 893 347 . . . 661 2863 NT2NE20073650 894 756 . . .
1088 2864 NT2NE20077250 895 1815 . . . 3185 2865 NT2NE20077270 896
250 . . . >3642 2866 NT2NE20077860 897 589 . . . 1053 2867
NT2NE20079670 898 404 . . . 1867 2868 NT2NE20080770 899 1181 . . .
1483 2869 NT2NE20082130 900 1026 . . . 1457 2870 NT2NE20082600 901
688 . . . 1227 2871 NT2NE20086070 902 503 . . . 823 2872
NT2NE20087270 903 276 . . . 1709 2873 NT2NE20087850 904 9 . . . 326
2874 NT2NE20088030 905 682 . . . 1023 2875 NT2NE20092950 906 142 .
. . 1884 2876 NT2NE20095230 907 547 . . . 1602 2877 NT2NE20104000
908 217 . . . 702 2878 NT2NE20107810 909 29 . . . 376 2879
NT2NE20108420 910 1135 . . . >2525 2880 NT2NE20111190 911 202 .
. . 651 2881 NT2NE20112210 912 963 . . . 2231 2882 NT2NE20114850
913 1441 . . . >1794 2883 NT2NE20117580 914 271 . . . 912 2884
NT2NE20119980 915 445 . . . 843 2885 NT2NE20123610 916 118 . . .
717 2886 NT2NE20124570 917 1279 . . . 1620 2887 NT2NE20126030 918
1054 . . . 1548 2888 NT2NE20127900 919 85 . . . 1599 2889
NT2NE20140130 920 355 . . . 753 2890 NT2NE20140280 921 126 . . .
989 2891 NT2NE20141040 922 53 . . . 811 2892 NT2NE20145250 923 94 .
. . 531 2893 NT2NE20146510 924 125 . . . 661 2894 NT2NE20148690 925
544 . . . 861 2895 NT2NE20149500 926 454 . . . 888 2896
NT2NE20150610 927 73 . . . 432 2897 NT2NE20152620 928 1080 . . .
2516 2898 NT2NE20153620 929 133 . . . 1512 2899 NT2NE20155650 930
716 . . . 1210 2900 NT2NE20157120 931 927 . . . 1271 2901
NT2NE20165190 932 85 . . . 531 2902 NT2NE20167660 933 20 . . . 349
2903 NT2NE20173970 934 274 . . . >2188 2904 NT2NE20177210 935
115 . . . 675 2905 NT2NE20181760 936 201 . . . 785 2906
NT2NE20181800 937 784 . . . 1137 2907 NT2NE20184720 938 1033 . . .
1506 2908 NT2RI20016240 939 359 . . . 748 2909 NT2RI20021200 940
534 . . . 875 2910 NT2RI20033920 941 269 . . . 1444 2911
NT2RI20093010 942 1478 . . . 1816 2912 NT2RP70001120 943 172 . . .
1518 2913 NT2RP70001730 944 166 . . . 1935 2914 NT2RP70003110 945
15 . . . 1868 2915 NT2RP70012830 946 280 . . . 2337 2916
NT2RP70022820 947 2819 . . . >3760 2917 NT2RP70027790 948 389 .
. . 2965 2918 NT2RP70029780 949 156 . . . 1349 2919 NT2RP70030840
950 278 . . . 2983 2920 NT2RP70031070 951 148 . . . 1740 2921
NT2RP70031340 952 107 . . . 1576 2922 NT2RP70031480 953 203 . . .
2947 2923 NT2RP70035110 954 106 . . . 765 2924 NT2RP70046410 955
155 . . . 1582 2925 NT2RP70049610 956 834 . . . 1889 2926
NT2RP70056290 957 2748 . . . 3182 2927 NT2RP70056690 958 253 . . .
>3053 2928 NT2RP70057500 959 216 . . . 2615 2929 NT2RP70064570
960 636 . . . 2162 2930 NT2RP70074800 961 199 . . . 684 2931
NT2RP70075300 962 226 . . . 1539 2932 NT2RP70075800 963 211 . . .
3801 2933 NT2RP70080150 964 306 . . . 674 2934 NT2RP70084540 965 8
. . . 406 2935 NT2RP70087140 966 175 . . . 1074 2936 NT2RP70090870
967 272 . . . 2617 2937 NTONG20002230 968 50 . . . >3211 2938
NTONG20005310 969 88 . . . 471 2939 NTONG20017620 970 40 . . . 432
2940 NTONG20029850 971 110 . . . 1258 2941 NTONG20031580 972 126 .
. . 863 2942 NTONG20032100 973 65 . . . 1132 2943 NTONG20034540 974
163 . . . 2523 2944 NTONG20035150 975 543 . . . 2477 2945
NTONG20043080 976 22 . . . 2679 2946 NTONG20048440 977 89 . . .
1849 2947 NTONG20049180 978 155 . . . 1300 2948
NTONG20053630 979 321 . . . 3821 2949 NTONG20053730 980 121 . . .
1701 2950 NTONG20053910 981 47 . . . 2758 2951 NTONG20055200 982
122 . . . 1969 2952 NTONG20058010 983 237 . . . 1559 2953
NTONG20058220 984 67 . . . 1314 2954 OCBBF20000740 985 165 . . .
2402 2955 OCBBF20001780 986 1990 . . . 2334 2956 OCBBF20005220 987
590 . . . 2299 2957 OCBBF20009820 988 281 . . . 823 2958
OCBBF20011860 989 145 . . . 528 2959 OCBBF20012520 990 786 . . .
3023 2960 OCBBF20016390 991 667 . . . 1617 2961 OCBBF20016810 992
123 . . . 2351 2962 OCBBF20109450 993 204 . . . 506 2963
OCBBF20109780 994 253 . . . 573 2964 OCBBF20110210 995 8 . . . 1072
2965 OCBBF20110730 996 1346 . . . 1666 2966 OCBBF20111370 997 296 .
. . 1345 2967 OCBBF20111600 998 375 . . . 1823 2968 OCBBF20112280
999 447 . . . 860 2969 OCBBF20112320 1000 72 . . . 857 2970
OCBBF20113110 1001 292 . . . 738 2971 OCBBF20115360 1002 1182 . . .
2126 2972 OCBBF20116250 1003 124 . . . 2175 2973 OCBBF20117220 1004
605 . . . 937 2974 OCBBF20118720 1005 131 . . . 451 2975
OCBBF20119810 1006 1483 . . . 2478 2976 OCBBF20120010 1007 216 . .
. 1106 2977 OCBBF20120950 1008 91 . . . 1629 2978 OCBBF20121910
1009 235 . . . 2580 2979 OCBBF20123200 1010 1046 . . . 1411 2980
OCBBF20142290 1011 94 . . . 900 2981 OCBBF20147070 1012 1193 . . .
3256 2982 OCBBF20152330 1013 284 . . . 613 2983 OCBBF20155030 1014
188 . . . 724 2984 OCBBF20156450 1015 104 . . . 1132 2985
OCBBF20157970 1016 1390 . . . 2313 2986 OCBBF20160380 1017 1176 . .
. 3884 2987 OCBBF20165900 1018 407 . . . 934 2988 OCBBF20165910
1019 1260 . . . 2495 2989 OCBBF20166890 1020 201 . . . 1121 2990
OCBBF20166900 1021 350 . . . >2606 2991 OCBBF20167290 1022 186 .
. . 2858 2992 OCBBF20170350 1023 8 . . . 499 2993 OCBBF20174580
1024 179 . . . 1294 2994 OCBBF20174890 1025 178 . . . 1380 2995
OCBBF20175360 1026 1394 . . . 1711 2996 OCBBF20176650 1027 121 . .
. 423 2997 OCBBF20177540 1028 334 . . . 1242 2998 OCBBF20177910
1029 1047 . . . 1688 2999 OCBBF20182060 1030 964 . . . 1827 3000
OCBBF20185630 1031 1839 . . . 2195 3001 OCBBF20188280 1032 322 . .
. 696 3002 OCBBF20191950 1033 47 . . . 2305 3003 PANCR10000860 1034
20 . . . 376 3004 PEBLM10001470 1035 155 . . . 1960 3005
PEBLM20001800 1036 59 . . . 1549 3006 PEBLM20003260 1037 660 . . .
1121 3007 PEBLM20005020 1038 315 . . . 647 3008 PLACE50001290 1039
620 . . . 1030 3009 PLACE50001390 1040 156 . . . 1376 3010
PLACE60001910 1041 1521 . . . 2252 3011 PLACE60004260 1042 562 . .
. 924 3012 PLACE60006300 1043 12 . . . 725 3013 PLACE60011180 1044
526 . . . 894 3014 PLACE60012620 1045 106 . . . 1368 3015
PLACE60017120 1046 1116 . . . 1454 3016 PLACE60052940 1047 385 . .
. >2108 3017 PLACE60053280 1048 161 . . . >2687 3018
PLACE60054230 1049 189 . . . 1550 3019 PLACE60054820 1050 298 . . .
852 3020 PLACE60054870 1051 105 . . . 2213 3021 PLACE60055350 1052
1188 . . . 1562 3022 PLACE60055460 1053 160 . . . 1197 3023
PLACE60055590 1054 123 . . . 1406 3024 PLACE60056910 1055 1028 . .
. 1549 3025 PLACE60057860 1056 1617 . . . 1940 3026 PLACE60061370
1057 1 . . . 1899 3027 PLACE60062660 1058 97 . . . 954 3028
PLACE60062870 1059 604 . . . 1278 3029 PLACE60063940 1060 459 . . .
797 3030 PLACE60064180 1061 167 . . . 1240 3031 PLACE60064740 1062
302 . . . 952 3032 PLACE60066970 1063 697 . . . 1998 3033
PLACE60068710 1064 363 . . . 1139 3034 PLACE60069880 1065 898 . . .
1374 3035 PLACE60070500 1066 765 . . . 1718 3036 PLACE60071800 1067
689 . . . 1333 3037 PLACE60072390 1068 145 . . . 522 3038
PLACE60072420 1069 289 . . . 684 3039 PLACE60073090 1070 384 . . .
1814 3040 PLACE60074820 1071 38 . . . 727 3041 PLACE60077870 1072
2280 . . . 2609 3042 PLACE60080360 1073 285 . . . 938 3043
PLACE60081260 1074 1192 . . . 1860 3044 PLACE60082850 1075 665 . .
. 1132 3045 PLACE60087680 1076 3 . . . 836 3046 PLACE60088240 1077
94 . . . 570 3047 PLACE60092280 1078 180 . . . 869 3048
PLACE60092370 1079 371 . . . 691 3049 PLACE60093380 1080 433 . . .
1335 3050 PLACE60095240 1081 956 . . . 1312 3051 PLACE60095600 1082
4 . . . >2605 3052 PLACE60098350 1083 86 . . . 1852 3053
PLACE60104630 1084 1267 . . . 1671 3054 PLACE60105680 1085 1290 . .
. 1631 3055 PLACE60107010 1086 128 . . . 829 3056 PLACE60109910
1087 4 . . . 567 3057 PLACE60113340 1088 127 . . . 1518 3058
PLACE60118810 1089 101 . . . 1657 3059 PLACE60119700 1090 199 . . .
516 3060 PLACE60120280 1091 61 . . . 705 3061 PLACE60122970 1092
861 . . . >1396 3062 PLACE60132200 1093 240 . . . 1082 3063
PLACE60132320 1094 471 . . . 1121 3064 PLACE60132880 1095 495 . . .
1406 3065 PLACE60138840 1096 729 . . . 1553 3066 PLACE60140640 1097
840 . . . 1919 3067 PLACE60150510 1098 215 . . . 1246 3068
PLACE60154450 1099 25 . . . 873 3069 PLACE60155910 1100 255 . . .
701 3070 PLACE60157310 1101 1156 . . . 1482 3071 PLACE60162100 1102
885 . . . 1226 3072 PLACE60175640 1103 242 . . . 556 3073
PLACE60177880 1104 104 . . . 1327 3074 PLACE60177910 1105 59 . . .
442 3075 PLACE60181870 1106 131 . . . 673 3076 PLACE60184410 1107
995 . . . 1483 3077 PLACE60184870 1108 86 . . . >1402 3078
PLACE60188630 1109 571 . . . 1395 3079 PROST10001100 1110 716 . . .
1219 3080 PROST10001360 1111 1506 . . . 1997 3081 PROST10002150
1112 840 . . . 2345 3082 PROST20007170 1113 216 . . . 1679 3083
PROST20007600 1114 29 . . . 742 3084 PROST20011160 1115 150 . . .
548 3085 PROST20011800 1116 1297 . . . 1629 3086 PROST20014140 1117
1901 . . . 3022 3087 PROST20014150 1118 1632 . . . 1961 3088
PROST20014650 1119 1243 . . . 1653 3089 PROST20015210 1120 711 . .
. 1499 3090 PROST20015400 1121 49 . . . 399 3091 PROST20016760 1122
62 . . . 1870 3092 PROST20022120 1123 301 . . . 762 3093
PROST20024250 1124 38 . . . 445 3094 PROST20028970 1125 30 . . .
821 3095 PROST20033240 1126 39 . . . 1682 3096 PROST20035170 1127
689 . . . 1078 3097 PROST20035830 1128 1154 . . . 1468 3098
PROST20036280 1129 1801 . . . 2295 3099 PROST20036350 1130 22 . . .
2175 3100 PROST20039300 1131 87 . . . 635 3101 PROST20041460 1132
427 . . . 855 3102 PROST20042700 1133 461 . . . 1081 3103
PROST20045700 1134 472 . . . 975 3104 PROST20047440 1135 1058 . . .
1441 3105 PROST20048170 1136 73 . . . 555 3106 PROST20050390 1137
1358 . . . 2035 3107 PROST20051310 1138 1913 . . . 2737 3108
PROST20052720 1139 1195 . . . 1515 3109 PROST20052850 1140 430 . .
. 1185 3110 PROST20054660 1141 55 . . . 753 3111 PROST20058860 1142
506 . . . 892 3112 PROST20060200 1143 103 . . . 429 3113
PROST20062820 1144 415 . . . 1215 3114 PROST20063430 1145 126 . . .
1199 3115 PROST20065100 1146 95 . . . 1522 3116 PROST20065790 1147
225 . . . 2555 3117 PROST20073280 1148 891 . . . 1277 3118
PROST20075280 1149 97 . . . 885 3119 PROST20078710 1150 347 . . .
1213 3120 PROST20082430 1151 2077 . . . 2436 3121 PROST20084470
1152 728 . . . 1498 3122 PROST20084680 1153 395 . . . 733 3123
PROST20084720 1154 1528 . . . 1839 3124 PROST20087240 1155 766 . .
. 1452 3125 PROST20093470 1156 1288 . . . 1647 3126 PROST20094000
1157 376 . . . 1011 3127 PROST20097310 1158 1502 . . . 1903 3128
PROST20097360 1159 99 . . . 602 3129 PROST20097840 1160 687 . . .
1289 3130 PROST20099090 1161 85 . . . 792 3131 PROST20102190 1162
86 . . . 406 3132 PROST20102500 1163 1467 . . . 2051 3133
PROST20103820 1164 1770 . . . 2078 3134 PROST20105450 1165 1027 . .
. 1911 3135 PROST20106060 1166 97 . . . 705 3136 PROST20108850 1167
1173 . . . 1664 3137 PROST20110120 1168 804 . . . 1139 3138
PROST20114100 1169 74 . . . 772 3139 PROST20120070 1170 442 . . .
1593 3140 PROST20121570 1171 673 . . . 1185 3141 PROST20122490 1172
10 . . . 753 3142 PROST20124000 1173 943 . . . 1371 3143
PROST20125420 1174 1480 . . . 1968 3144 PROST20127450 1175 255 . .
. 857 3145 PROST20130320 1176 549 . . . 2309 3146 PROST20138730
1177 494 . . . 829 3147 PROST20146590 1178 618 . . . 2351 3148
PROST20151370 1179 99 . . . 482 3149 PROST20152510 1180 1095 . . .
2168 3150 PROST20152870 1181 258 . . . 1322 3151 PROST20155370 1182
606 . . . 2255 3152 PROST20156360 1183 1557 . . . 1898 3153
PROST20159320 1184 67 . . . 567 3154 PROST20168600 1185 336 . . .
1700 3155 PUAEN10000650 1186 341 . . . 943 3156 PUAEN10000870 1187
1676 . . . 2029 3157 PUAEN10001640 1188 332 . . . 1138 3158
PUAEN20000800 1189 327 . . . 1811 3159 PUAEN20001520 1190 155 . . .
1243 3160 PUAEN20002470 1191 3 . . . 2417 3161 PUAEN20003120 1192
93 . . . 2216 3162 SALGL10001070 1193 89 . . . 997 3163
SKMUS20006790 1194 389 . . . 1330 3164 SKMUS20007260 1195 47 . . .
>1320 3165 SKMUS20008730 1196 91 . . . 1407 3166 SKMUS20017400
1197 84 . . . 815 3167 SKMUS20020770 1198 179 . . . 781 3168
SKMUS20026340 1199 57 . . . 1202 3169 SKMUS20040440 1200 27 . . .
1091 3170 SKMUS20064810 1201 91 . . . 459 3171 SKMUS20073150 1202
17 . . . >822 3172 SKMUS20073590 1203 438 . . . 824 3173
SKMUS20079150 1204 165 . . . 1235 3174 SKMUS20091900 1205 57 . . .
359 3175 SKNMC10001230 1206 87 . . . 1814 3176 SKNMC20006350 1207
326 . . . 1738 3177 SKNSH10001010 1208 1189 . . . 1530 3178
SKNSH20007160 1209 113 . . . 562 3179 SKNSH20009710 1210 71 . . .
622 3180 SKNSH20030640 1211 1635 . . . 2090 3181 SKNSH20040390 1212
246 . . . 911 3182 SKNSH20052400 1213 926 . . . 2017 3183
SKNSH20057920 1214 369 . . . 1352 3184 SKNSH20068220 1215 504 . . .
1235 3185 SKNSH20094350 1216 70 . . . 591 3186 SMINT20000070 1217
752 . . . 1858 3187 SMINT20002320 1218 607 . . . 1761 3188
SMINT20006020 1219 1215 . . . 2348 3189 SMINT20006090 1220 75 . . .
602 3190 SMINT20007470 1221 154 . . . 1650 3191 SMINT20008110 1222
784 . . . 1557 3192 SMINT20011830 1223 34 . . . 447 3193
SMINT20011950 1224 732 . . . 2006 3194 SMINT20012220 1225 239 . . .
616 3195 SMINT20013970 1226 1117 . . . 1686 3196 SMINT20014610 1227
287 . . . 814 3197 SMINT20016150 1228 911 . . . 1675 3198
SMINT20017310 1229 1220 . . . 1561 3199
SMINT20021260 1230 1066 . . . 1407 3200 SMINT20023110 1231 1696 . .
. 2073 3201 SMINT20024140 1232 31 . . . 555 3202 SMINT20026200 1233
323 . . . 2170 3203 SMINT20028800 1234 476 . . . 1696 3204
SMINT20028840 1235 89 . . . 823 3205 SMINT20030740 1236 172 . . .
1833 3206 SMINT20031280 1237 542 . . . 1489 3207 SMINT20035050 1238
227 . . . 2149 3208 SMINT20035510 1239 168 . . . >1891 3209
SMINT20036440 1240 207 . . . 2084 3210 SMINT20038660 1241 289 . . .
1449 3211 SMINT20039050 1242 175 . . . >2338 3212 SMINT20043390
1243 1465 . . . 2094 3213 SMINT20044140 1244 30 . . . 1718 3214
SMINT20044730 1245 45 . . . 1787 3215 SMINT20045470 1246 1156 . . .
1539 3216 SMINT20045830 1247 287 . . . 1882 3217 SMINT20045890 1248
893 . . . 1372 3218 SMINT20047290 1249 2 . . . 637 3219
SMINT20048720 1250 1834 . . . >2374 3220 SMINT20049920 1251 1384
. . . 1860 3221 SMINT20052130 1252 271 . . . 891 3222 SMINT20054050
1253 361 . . . 1839 3223 SMINT20056230 1254 73 . . . 1674 3224
SMINT20056240 1255 1108 . . . 1533 3225 SMINT20062050 1256 75 . . .
1964 3226 SMINT20067080 1257 138 . . . 2075 3227 SMINT20070620 1258
44 . . . 445 3228 SMINT20074330 1259 71 . . . 532 3229
SMINT20077920 1260 843 . . . 1166 3230 SMINT20077960 1261 1010 . .
. 2467 3231 SMINT20081330 1262 250 . . . 618 3232 SMINT20083290
1263 80 . . . 1606 3233 SMINT20084910 1264 664 . . . 987 3234
SMINT20085310 1265 129 . . . 500 3235 SMINT20085450 1266 66 . . .
437 3236 SMINT20086250 1267 1958 . . . 2287 3237 SMINT20086720 1268
233 . . . 1003 3238 SMINT20088440 1269 31 . . . 438 3239
SMINT20088690 1270 26 . . . 580 3240 SMINT20089210 1271 1259 . . .
1672 3241 SMINT20089600 1272 241 . . . 1335 3242 SMINT20091190 1273
290 . . . 1765 3243 SMINT20092120 1274 33 . . . 416 3244
SMINT20092160 1275 439 . . . 780 3245 SMINT20093630 1276 1822 . . .
2241 3246 SMINT20094150 1277 511 . . . 966 3247 SMINT20094680 1278
36 . . . 452 3248 SPLEN20005160 1279 2342 . . . 2659 3249
SPLEN20005370 1280 1497 . . . 1856 3250 SPLEN20006950 1281 702 . .
. 1343 3251 SPLEN20011350 1282 1127 . . . 1537 3252 SPLEN20012450
1283 134 . . . 442 3253 SPLEN20015030 1284 376 . . . 945 3254
SPLEN20015100 1285 1367 . . . 2137 3255 SPLEN20016500 1286 328 . .
. 816 3256 SPLEN20017610 1287 940 . . . 1314 3257 SPLEN20017810
1288 101 . . . 556 3258 SPLEN20019120 1289 176 . . . 487 3259
SPLEN20020530 1290 358 . . . 762 3260 SPLEN20023430 1291 1067 . . .
1426 3261 SPLEN20023540 1292 644 . . . 1903 3262 SPLEN20023850 1293
467 . . . >1879 3263 SPLEN20024190 1294 319 . . . 1368 3264
SPLEN20024510 1295 1070 . . . 1423 3265 SPLEN20024620 1296 3 . . .
1514 3266 SPLEN20024770 1297 134 . . . 2353 3267 SPLEN20024930 1298
1150 . . . 3069 3268 SPLEN20029170 1299 67 . . . 750 3269
SPLEN20036780 1300 1432 . . . 1752 3270 SPLEN20039180 1301 359 . .
. 1534 3271 SPLEN20040780 1302 1675 . . . 2346 3272 SPLEN20041810
1303 801 . . . 1142 3273 SPLEN20042200 1304 1123 . . . 1935 3274
SPLEN20043430 1305 224 . . . 565 3275 SPLEN20043460 1306 55 . . .
1899 3276 SPLEN20043680 1307 1337 . . . 2371 3277 SPLEN20045550
1308 5 . . . 1513 3278 SPLEN20048800 1309 2038 . . . 2352 3279
SPLEN20049840 1310 82 . . . 3378 3280 SPLEN20050090 1311 418 . . .
2202 3281 SPLEN20051420 1312 685 . . . 1983 3282 SPLEN20054160 1313
186 . . . 2069 3283 SPLEN20054500 1314 667 . . . 1443 3284
SPLEN20055600 1315 146 . . . 1033 3285 SPLEN20057830 1316 507 . . .
1163 3286 SPLEN20057900 1317 1883 . . . 2431 3287 SPLEN20058180
1318 803 . . . 1120 3288 SPLEN20059270 1319 162 . . . 1586 3289
SPLEN20062830 1320 282 . . . 785 3290 SPLEN20063250 1321 315 . . .
1535 3291 SPLEN20063890 1322 133 . . . 996 3292 SPLEN20067010 1323
2702 . . . >3023 3293 SPLEN20071820 1324 876 . . . 1592 3294
SPLEN20073500 1325 174 . . . 2210 3295 SPLEN20073880 1326 220 . . .
2595 3296 SPLEN20076190 1327 20 . . . 331 3297 SPLEN20076470 1328
575 . . . 1714 3298 SPLEN20080070 1329 5 . . . 1339 3299
SPLEN20081640 1330 946 . . . 1308 3300 SPLEN20085910 1331 1084 . .
. 1434 3301 SPLEN20087370 1332 2670 . . . 3098 3302 SPLEN20087860
1333 255 . . . 755 3303 SPLEN20090880 1334 1742 . . . 2194 3304
SPLEN20098030 1335 268 . . . 1077 3305 SPLEN20100040 1336 101 . . .
862 3306 SPLEN20101950 1337 122 . . . 1198 3307 SPLEN20104150 1338
1146 . . . 2219 3308 SPLEN20104690 1339 661 . . . 990 3309
SPLEN20105100 1340 1425 . . . 1859 3310 SPLEN20108000 1341 887 . .
. 1351 3311 SPLEN20108460 1342 2254 . . . 2607 3312 SPLEN20110180
1343 147 . . . 1292 3313 SPLEN20110210 1344 1831 . . . 2271 3314
SPLEN20110860 1345 1489 . . . 1887 3315 SPLEN20111450 1346 2768 . .
. 3208 3316 SPLEN20114190 1347 154 . . . 1440 3317 SPLEN20116720
1348 9 . . . 1583 3318 SPLEN20117580 1349 218 . . . 1240 3319
SPLEN20118050 1350 145 . . . 1122 3320 SPLEN20121790 1351 569 . . .
1054 3321 SPLEN20125230 1352 971 . . . 1324 3322 SPLEN20126110 1353
254 . . . 991 3323 SPLEN20135030 1354 40 . . . 1848 3324
SPLEN20136700 1355 1296 . . . 1628 3325 SPLEN20136730 1356 1312 . .
. 1644 3326 SPLEN20137530 1357 2676 . . . 3221 3327 SPLEN20138600
1358 1166 . . . 1582 3328 SPLEN20139100 1359 63 . . . 1532 3329
SPLEN20139360 1360 763 . . . 1827 3330 SPLEN20175920 1361 1123 . .
. 1590 3331 SPLEN20176130 1362 16 . . . 549 3332 SPLEN20177400 1363
1078 . . . 1431 3333 SPLEN20180980 1364 410 . . . 823 3334
SPLEN20181570 1365 214 . . . >2609 3335 SPLEN20182850 1366 168 .
. . 659 3336 SPLEN20182990 1367 55 . . . 1881 3337 SPLEN20183020
1368 265 . . . 723 3338 SPLEN20183950 1369 402 . . . 746 3339
SPLEN20187490 1370 98 . . . >2458 3340 SPLEN20190080 1371 914 .
. . 1342 3341 SPLEN20190430 1372 884 . . . >1942 3342
SPLEN20190770 1373 97 . . . 771 3343 SPLEN20191020 1374 140 . . .
1426 3344 SPLEN20192570 1375 325 . . . 654 3345 SPLEN20193230 1376
253 . . . 588 3346 SPLEN20193490 1377 321 . . . 854 3347
SPLEN20193750 1378 845 . . . 1306 3348 SPLEN20193790 1379 290 . . .
2278 3349 SPLEN20195710 1380 64 . . . 516 3350 SPLEN20197090 1381
11 . . . 550 3351 SPLEN20197740 1382 2 . . . 499 3352 SPLEN20197930
1383 803 . . . >1625 3353 SPLEN20198390 1384 14 . . . 1873 3354
SPLEN20199850 1385 575 . . . 1009 3355 SPLEN20200070 1386 353 . . .
655 3356 SPLEN20200340 1387 1047 . . . 1814 3357 SPLEN20201830 1388
143 . . . 1177 3358 SPLEN20203590 1389 160 . . . 471 3359
SPLEN20204670 1390 6 . . . 311 3360 SPLEN20205120 1391 682 . . .
1542 3361 TESOP10000350 1392 1646 . . . 2101 3362 TESOP10001600
1393 282 . . . 1352 3363 TESTI10000190 1394 84 . . . 2042 3364
TESTI10000850 1395 925 . . . 1311 3365 TESTI10001570 1396 141 . . .
1919 3366 TESTI20004310 1397 55 . . . 2484 3367 TESTI20005980 1398
1350 . . . >1866 3368 TESTI20006160 1399 53 . . . 1720 3369
TESTI20006830 1400 313 . . . 1719 3370 TESTI20012080 1401 89 . . .
1867 3371 TESTI20012360 1402 178 . . . 594 3372 TESTI20016970 1403
133 . . . 1842 3373 TESTI20019590 1404 210 . . . 752 3374
TESTI20028020 1405 201 . . . 1298 3375 TESTI20029100 1406 1743 . .
. 2147 3376 TESTI20030200 1407 94 . . . 2091 3377 TESTI20030440
1408 60 . . . 1931 3378 TESTI20030610 1409 547 . . . 1371 3379
TESTI20031310 1410 889 . . . 2235 3380 TESTI20031410 1411 201 . . .
1655 3381 TESTI20032770 1412 163 . . . 1002 3382 TESTI20034750 1413
472 . . . 804 3383 TESTI20035330 1414 13 . . . 558 3384
TESTI20035790 1415 16 . . . 2163 3385 TESTI20038240 1416 163 . . .
2502 3386 TESTI20040850 1417 52 . . . 669 3387 TESTI20041630 1418
330 . . . 1526 3388 TESTI20043130 1419 410 . . . 715 3389
TESTI20043180 1420 68 . . . 2515 3390 TESTI20043220 1421 1496 . . .
1957 3391 TESTI20043910 1422 37 . . . 1728 3392 TESTI20043990 1423
311 . . . 1153 3393 TESTI20044900 1424 234 . . . 1595 3394
TESTI20045390 1425 156 . . . 2108 3395 TESTI20045740 1426 199 . . .
549 3396 TESTI20046110 1427 24 . . . 1826 3397 TESTI20046490 1428
554 . . . 2542 3398 TESTI20046540 1429 123 . . . 2309 3399
TESTI20046870 1430 278 . . . 1645 3400 TESTI20046890 1431 276 . . .
2702 3401 TESTI20047370 1432 2 . . . 2134 3402 TESTI20047930 1433
239 . . . 1843 3403 TESTI20049060 1434 1191 . . . 1784 3404
TESTI20049410 1435 281 . . . 2170 3405 TESTI20049990 1436 355 . . .
915 3406 TESTI20050170 1437 314 . . . 808 3407 TESTI20050400 1438
111 . . . 440 3408 TESTI20050720 1439 68 . . . 1621 3409
TESTI20051200 1440 1561 . . . 2145 3410 TESTI20051730 1441 183 . .
. 1943 3411 TESTI20052670 1442 759 . . . 1910 3412 TESTI20053070
1443 98 . . . 1285 3413 TESTI20053260 1444 456 . . . 842 3414
TESTI20053780 1445 176 . . . 1948 3415 TESTI20053800 1446 42 . . .
1694 3416 TESTI20053950 1447 528 . . . >1782 3417 TESTI20054700
1448 19 . . . 1956 3418 TESTI20055680 1449 53 . . . 1510 3419
TESTI20055880 1450 127 . . . 1644 3420 TESTI20056030 1451 543 . . .
1658 3421 TESTI20057200 1452 279 . . . 611 3422 TESTI20057430 1453
131 . . . 1858 3423 TESTI20057590 1454 37 . . . 1062 3424
TESTI20057840 1455 180 . . . 1271 3425 TESTI20057880 1456 39 . . .
1697 3426 TESTI20058350 1457 25 . . . 1368 3427 TESTI20058920 1458
108 . . . 1088 3428 TESTI20059080 1459 2134 . . . 3069 3429
TESTI20059330 1460 540 . . . 845 3430 TESTI20059370 1461 655 . . .
1137 3431 TESTI20059480 1462 52 . . . 1362 3432 TESTI20059790 1463
203 . . . 1336 3433 TESTI20059810 1464 324 . . . >1914 3434
TESTI20060080 1465 172 . . . 858 3435 TESTI20060150 1466 383 . . .
1663 3436 TESTI20060350 1467 81 . . . 1427 3437 TESTI20060450 1468
1306 . . . 1752 3438 TESTI20060830 1469 54 . . . 2543 3439
TESTI20061090 1470 382 . . . 798 3440 TESTI20061200 1471 382 . . .
1938 3441 TESTI20062120 1472 37 . . . 1632 3442 TESTI20062180 1473
169 . . . 1413 3443 TESTI20062580 1474 863 . . . 1165 3444
TESTI20063330 1475 1334 . . . 1678 3445 TESTI20063410 1476 2175 . .
. 2501 3446 TESTI20063600 1477 1399 . . . 1809 3447 TESTI20064370
1478 201 . . . 1706 3448 TESTI20064530 1479 68 . . . 2737 3449
TESTI20064650 1480 353 . . . 2542 3450
TESTI20064990 1481 733 . . . 1290 3451 TESTI20065650 1482 374 . . .
1609 3452 TESTI20066150 1483 98 . . . 2473 3453 TESTI20066170 1484
143 . . . 1309 3454 TESTI20066280 1485 100 . . . 879 3455
TESTI20066330 1486 26 . . . 1528 3456 TESTI20066590 1487 306 . . .
740 3457 TESTI20066650 1488 415 . . . 1362 3458 TESTI20067350 1489
342 . . . 1073 3459 TESTI20067440 1490 196 . . . 1887 3460
TESTI20067480 1491 127 . . . 1758 3461 TESTI20068530 1492 791 . . .
1369 3462 TESTI20068790 1493 1033 . . . >1738 3463 TESTI20068940
1494 55 . . . >1867 3464 TESTI20070400 1495 147 . . . 2300 3465
TESTI20070740 1496 743 . . . 1480 3466 TESTI20071130 1497 224 . . .
1738 3467 TESTI20071630 1498 38 . . . 727 3468 TESTI20073460 1499
97 . . . 1584 3469 TESTI20075240 1500 259 . . . 1686 3470
TESTI20076570 1501 622 . . . 1110 3471 TESTI20076920 1502 90 . . .
608 3472 TESTI20079060 1503 105 . . . 2096 3473 TESTI20079220 1504
54 . . . 2252 3474 TESTI20079980 1505 62 . . . 1300 3475
TESTI20080460 1506 1458 . . . 1787 3476 TESTI20081890 1507 184 . .
. 2520 3477 TESTI20083890 1508 1102 . . . 1596 3478 TESTI20084250
1509 386 . . . 2035 3479 TESTI20085670 1510 1459 . . . 2001 3480
TESTI20086840 1511 10 . . . 1488 3481 TESTI20088840 1512 172 . . .
1587 3482 TESTI20089290 1513 26 . . . 421 3483 TESTI20090180 1514
527 . . . 1657 3484 TESTI20090970 1515 548 . . . 2308 3485
TESTI20091360 1516 745 . . . 1230 3486 TESTI20092170 1517 882 . . .
1256 3487 TESTI20093900 1518 265 . . . 1791 3488 TESTI20094620 1519
1897 . . . 2319 3489 TESTI20095200 1520 94 . . . 1149 3490
TESTI20095440 1521 1134 . . . 1496 3491 TESTI20095770 1522 278 . .
. >2225 3492 TESTI20095880 1523 144 . . . 1775 3493
TESTI20097270 1524 157 . . . 693 3494 TESTI20099350 1525 123 . . .
>1773 3495 TESTI20100090 1526 1020 . . . 2057 3496 TESTI20102390
1527 1873 . . . 2247 3497 TESTI20103690 1528 71 . . . 1048 3498
TESTI20104090 1529 364 . . . 1716 3499 TESTI20105130 1530 320 . . .
1966 3500 TESTI20105910 1531 151 . . . 2265 3501 TESTI20106170 1532
235 . . . 1338 3502 TESTI20106820 1533 1191 . . . 1604 3503
TESTI20107240 1534 163 . . . 2844 3504 TESTI20107320 1535 377 . . .
787 3505 TESTI20107340 1536 1229 . . . 1723 3506 TESTI20108060 1537
371 . . . 925 3507 TESTI20112540 1538 148 . . . 1554 3508
TESTI20112860 1539 285 . . . 1829 3509 TESTI20113150 1540 374 . . .
1042 3510 TESTI20113940 1541 1185 . . . 1598 3511 TESTI20114480
1542 161 . . . 2032 3512 TESTI20116050 1543 218 . . . 1756 3513
TESTI20116120 1544 17 . . . 1276 3514 TESTI20117500 1545 140 . . .
508 3515 TESTI20118460 1546 69 . . . 1580 3516 TESTI20120500 1547
135 . . . 926 3517 TESTI20120900 1548 60 . . . 665 3518
TESTI20121040 1549 8 . . . 1525 3519 TESTI20121710 1550 278 . . .
1543 3520 TESTI20122070 1551 145 . . . 1359 3521 TESTI20122440 1552
25 . . . 465 3522 TESTI20124440 1553 469 . . . 801 3523
TESTI20125280 1554 371 . . . 1363 3524 TESTI20125440 1555 342 . . .
671 3525 TESTI20125920 1556 31 . . . 1680 3526 TESTI20126280 1557
169 . . . 2562 3527 TESTI20130530 1558 298 . . . 1692 3528
TESTI20131440 1559 223 . . . 1278 3529 TESTI20132310 1560 204 . . .
713 3530 TESTI20132680 1561 1011 . . . 1448 3531 TESTI20134010 1562
334 . . . 1464 3532 TESTI20134270 1563 59 . . . 601 3533
TESTI20134680 1564 324 . . . 2726 3534 TESTI20134970 1565 197 . . .
1873 3535 TESTI20136010 1566 152 . . . >1415 3536 TESTI20140970
1567 376 . . . 801 3537 TESTI20142480 1568 1466 . . . 1939 3538
TESTI20142540 1569 1231 . . . 1593 3539 TESTI20143180 1570 201 . .
. 1946 3540 TESTI20144390 1571 776 . . . 1552 3541 TESTI20145780
1572 1315 . . . 1746 3542 TESTI20148380 1573 32 . . . 2680 3543
TESTI20149880 1574 581 . . . 982 3544 TESTI20150420 1575 221 . . .
1162 3545 TESTI20150920 1576 142 . . . 1713 3546 TESTI20151050 1577
1290 . . . 1736 3547 TESTI20151800 1578 671 . . . 1099 3548
TESTI20152490 1579 717 . . . 1226 3549 TESTI20153310 1580 151 . . .
1317 3550 TESTI20154370 1581 192 . . . 1544 3551 TESTI20159380 1582
852 . . . 1679 3552 TESTI20161010 1583 33 . . . 539 3553
TESTI20162780 1584 607 . . . 1299 3554 TESTI20162980 1585 224 . . .
1414 3555 TESTI20164210 1586 526 . . . 1593 3556 TESTI20165680 1587
154 . . . 552 3557 TESTI20165990 1588 201 . . . 992 3558
TESTI20166290 1589 351 . . . 2786 3559 TESTI20166670 1590 754 . . .
1938 3560 TESTI20167580 1591 1152 . . . >1543 3561 TESTI20168880
1592 201 . . . 524 3562 TESTI20169500 1593 280 . . . 1674 3563
TESTI20170170 1594 199 . . . 1530 3564 TESTI20170280 1595 1 . . .
696 3565 TESTI20170690 1596 61 . . . 474 3566 TESTI20170890 1597
882 . . . 1238 3567 TESTI20171070 1598 1088 . . . 1501 3568
TESTI20173050 1599 724 . . . 1218 3569 TESTI20173110 1600 1194 . .
. 1586 3570 TESTI20173960 1601 376 . . . 1764 3571 TESTI20175370
1602 828 . . . 1724 3572 TESTI20176450 1603 1 . . . 996 3573
TESTI20179230 1604 162 . . . 1709 3574 TESTI20179510 1605 1702 . .
. >2042 3575 TESTI20180600 1606 162 . . . 857 3576 TESTI20182210
1607 736 . . . 1182 3577 TESTI20182760 1608 266 . . . 1390 3578
TESTI20183680 1609 778 . . . >1927 3579 TESTI20184280 1610 35 .
. . >1732 3580 TESTI20184750 1611 899 . . . 2116 3581
TESTI20184760 1612 161 . . . 1741 3582 TESTI20184820 1613 189 . . .
722 3583 TESTI20186110 1614 221 . . . 1606 3584 TESTI20192570 1615
109 . . . 687 3585 TESTI20193080 1616 149 . . . 2194 3586
TESTI20193520 1617 311 . . . 1375 3587 TESTI20194880 1618 616 . . .
1554 3588 TESTI20196690 1619 271 . . . 945 3589 TESTI20196970 1620
789 . . . 1565 3590 TESTI20197030 1621 263 . . . 1717 3591
TESTI20197290 1622 643 . . . 1314 3592 TESTI20197600 1623 100 . . .
909 3593 TESTI20198540 1624 21 . . . 1553 3594 TESTI20198600 1625
909 . . . 1328 3595 TESTI20199110 1626 622 . . . 1617 3596
TESTI20199980 1627 764 . . . 1102 3597 TESTI20200120 1628 661 . . .
966 3598 TESTI20200840 1629 378 . . . 818 3599 TESTI20201760 1630
22 . . . 603 3600 TESTI20202830 1631 631 . . . 972 3601
TESTI20204260 1632 714 . . . 1406 3602 TESTI20205100 1633 270 . . .
1763 3603 TESTI20205150 1634 1286 . . . 1663 3604 TESTI20205250
1635 32 . . . 1888 3605 TESTI20207170 1636 1 . . . 795 3606
TESTI20209050 1637 269 . . . 1900 3607 TESTI20210030 1638 328 . . .
675 3608 TESTI20210570 1639 280 . . . 1362 3609 TESTI20211380 1640
372 . . . 848 3610 TESTI20212970 1641 93 . . . 2102 3611
TESTI20214630 1642 690 . . . 1106 3612 TESTI20215310 1643 294 . . .
899 3613 TESTI20219110 1644 982 . . . 1344 3614 TESTI20219390 1645
253 . . . 573 3615 TESTI20220230 1646 116 . . . 967 3616
TESTI20221790 1647 109 . . . 1830 3617 TESTI20222030 1648 277 . . .
2277 3618 TESTI20222460 1649 162 . . . 1889 3619 TESTI20223380 1650
322 . . . 831 3620 TESTI20226520 1651 178 . . . 1392 3621
TESTI20227380 1652 20 . . . 1747 3622 TESTI20228120 1653 31 . . .
858 3623 TESTI20228740 1654 607 . . . 1026 3624 TESTI20244220 1655
757 . . . 2448 3625 TESTI20244430 1656 17 . . . 1444 3626
TESTI20244460 1657 684 . . . 1511 3627 TESTI20244730 1658 127 . . .
1044 3628 TESTI20245600 1659 255 . . . 1523 3629 TESTI20245860 1660
684 . . . 1058 3630 TESTI20246410 1661 1513 . . . 1818 3631
TESTI20246480 1662 380 . . . 1399 3632 TESTI20247440 1663 425 . . .
907 3633 TESTI20248850 1664 3 . . . 1829 3634 TESTI20249360 1665
600 . . . 1565 3635 TESTI20250220 1666 63 . . . 2015 3636
TESTI20250630 1667 482 . . . 1690 3637 TESTI20251440 1668 42 . . .
1271 3638 TESTI20251610 1669 430 . . . 1218 3639 TESTI20251740 1670
730 . . . 1104 3640 TESTI20252690 1671 1182 . . . 2138 3641
TESTI20254030 1672 363 . . . 1958 3642 TESTI20254090 1673 878 . . .
1360 3643 TESTI20254480 1674 320 . . . 1390 3644 TESTI20254990 1675
693 . . . 1799 3645 TESTI20255460 1676 152 . . . 2710 3646
TESTI20256560 1677 169 . . . >2257 3647 TESTI20257910 1678 457 .
. . 1311 3648 TESTI20258720 1679 38 . . . 1630 3649 TESTI20259110
1680 486 . . . 1805 3650 TESTI20259200 1681 227 . . . 1369 3651
TESTI20260140 1682 1113 . . . 1421 3652 TESTI20260640 1683 6 . . .
1109 3653 TESTI20261040 1684 14 . . . 970 3654 TESTI20261160 1685
257 . . . 868 3655 TESTI20261680 1686 1422 . . . 1901 3656
TESTI20262150 1687 315 . . . 2765 3657 TESTI20262940 1688 255 . . .
1574 3658 TESTI20264530 1689 150 . . . 1580 3659 TESTI20264910 1690
1638 . . . 2378 3660 TESTI20265150 1691 1023 . . . 1409 3661
TESTI20265340 1692 965 . . . 1552 3662 TESTI20265890 1693 994 . . .
1308 3663 TESTI20266050 1694 116 . . . 1522 3664 TESTI20268240 1695
70 . . . 1638 3665 TESTI20269250 1696 17 . . . >1926 3666
TESTI20269360 1697 682 . . . 1005 3667 TESTI20270130 1698 99 . . .
512 3668 TESTI20271790 1699 101 . . . 1822 3669 TESTI20272380 1700
121 . . . 492 3670 TESTI20274960 1701 619 . . . 1716 3671
TESTI20277300 1702 263 . . . 1600 3672 TESTI20278280 1703 80 . . .
607 3673 TESTI20282420 1704 52 . . . 528 3674 TESTI20282530 1705
699 . . . 1985 3675 TESTI20282900 1706 30 . . . 341 3676
TESTI20284260 1707 29 . . . 493 3677 TESTI20285230 1708 1710 . . .
2366 3678 TESTI20286590 1709 519 . . . 1121 3679 TESTI20287760 1710
775 . . . 2634 3680 THYMU10004280 1711 617 . . . 988 3681
THYMU20006020 1712 608 . . . 1387 3682 THYMU20007020 1713 1755 . .
. 2111 3683 THYMU20007750 1714 1077 . . . 1499 3684 THYMU20008000
1715 1506 . . . 1955 3685 THYMU20009460 1716 1334 . . . 1723 3686
THYMU20009500 1717 717 . . . 2117 3687 THYMU20009710 1718 247 . . .
762 3688 THYMU20010180 1719 191 . . . 634 3689 THYMU20010710 1720
850 . . . 1164 3690 THYMU20012020 1721 1160 . . . 1561 3691
THYMU20012560 1722 47 . . . 517 3692 THYMU20013250 1723 131 . . .
1309 3693 THYMU20013810 1724 196 . . . 927 3694 THYMU20014430 1725
1280 . . . 1678 3695 THYMU20017270 1726 16 . . . 660 3696
THYMU20018250 1727 1205 . . . 2122 3697 THYMU20018390 1728 237 . .
. 1373 3698 THYMU20019000 1729 405 . . . 758 3699 THYMU20019260
1730 317 . . . 736 3700 THYMU20020370 1731 1332 . . . 1733 3701
THYMU20020800 1732 600 . . . 1196 3702 THYMU20021090 1733 211 . . .
1281 3703 THYMU20021540 1734 100 . . . 1578 3704 THYMU20023560 1735
1429 . . . 1884 3705 THYMU20024500 1736 199 . . . 1584 3706
THYMU20025480 1737 1362 . . . 1751 3707 THYMU20026950 1738 9 . . .
920 3708 THYMU20028150 1739 233 . . . 1222 3709 THYMU20028410 1740
10 . . . 1086 3710 THYMU20029830 1741 46 . . . 456 3711
THYMU20030460 1742 453 . . . 1175 3712 THYMU20030690 1743 1658 . .
. 2269 3713 THYMU20031330 1744 90 . . . 569 3714 THYMU20032820 1745
250 . . . 1176 3715 THYMU20034400 1746 791 . . . 1123 3716
THYMU20034790 1747 120 . . . 452 3717 THYMU20036500 1748 56 . . .
1657 3718 THYMU20039320 1749 584 . . . 1339 3719 THYMU20043440 1750
1301 . . . 1615 3720 THYMU20043560 1751 292 . . . 621 3721
THYMU20044100 1752 1800 . . . 2228 3722 THYMU20044520 1753 1387 . .
. 1899 3723 THYMU20046350 1754 1863 . . . 2351 3724 THYMU20046770
1755 321 . . . 671 3725 THYMU20049060 1756 172 . . . 732 3726
THYMU20050010 1757 206 . . . 1681 3727 THYMU20051340 1758 886 . . .
1209 3728 THYMU20052460 1759 1300 . . . 1683 3729 THYMU20052830
1760 92 . . . 1504 3730 THYMU20054800 1761 479 . . . 880 3731
THYMU20055450 1762 112 . . . 426 3732 THYMU20055460 1763 20 . . .
361 3733 THYMU20055740 1764 901 . . . 1341 3734 THYMU20055760 1765
232 . . . 738 3735 THYMU20058550 1766 1170 . . . 1493 3736
THYMU20060480 1767 2046 . . . >2453 3737 THYMU20062520 1768 299
. . . 655 3738 THYMU20062610 1769 136 . . . 1953 3739 THYMU20062770
1770 381 . . . 1199 3740 THYMU20063650 1771 264 . . . 800 3741
THYMU20064680 1772 253 . . . 621 3742 THYMU20066660 1773 405 . . .
1487 3743 THYMU20069130 1774 341 . . . 961 3744 THYMU20069460 1775
231 . . . 575 3745 THYMU20069650 1776 728 . . . 1036 3746
THYMU20070250 1777 81 . . . 1703 3747 THYMU20071120 1778 170 . . .
1792 3748 THYMU20071460 1779 152 . . . 499 3749 THYMU20072580 1780
1981 . . . 2286 3750 THYMU20073070 1781 551 . . . 1225 3751
THYMU20073080 1782 755 . . . 1198 3752 THYMU20077250 1783 645 . . .
1241 3753 THYMU20078020 1784 1290 . . . 1598 3754 THYMU20078240
1785 1506 . . . 1838 3755 THYMU20079690 1786 1049 . . . 1714 3756
THYMU20080490 1787 57 . . . 398 3757 THYMU20081110 1788 629 . . .
1246 3758 THYMU20083390 1789 592 . . . 924 3759 THYMU20083500 1790
744 . . . 1067 3760 THYMU20083830 1791 155 . . . 1786 3761
THYMU20084520 1792 286 . . . 597 3762 THYMU20086430 1793 769 . . .
1077 3763 THYMU20087270 1794 842 . . . 2008 3764 THYMU20089170 1795
305 . . . 619 3765 THYMU20089900 1796 1008 . . . 1421 3766
THYMU20090230 1797 106 . . . 594 3767 THYMU20091040 1798 728 . . .
1054 3768 THYMU20095920 1799 1809 . . . 2378 3769 THYMU20096580
1800 120 . . . 692 3770 THYMU20097920 1801 95 . . . 2086 3771
THYMU20098350 1802 99 . . . 1802 3772 THYMU20099060 1803 80 . . .
1573 3773 THYMU20100940 1804 8 . . . 2218 3774 THYMU20104480 1805
39 . . . 1451 3775 THYMU20106990 1806 673 . . . 1464 3776
THYMU20110720 1807 372 . . . 1070 3777 THYMU20112570 1808 117 . . .
455 3778 THYMU20112590 1809 112 . . . 1827 3779 THYMU20115380 1810
1507 . . . 1839 3780 THYMU20115730 1811 943 . . . 1632 3781
THYMU20117850 1812 1625 . . . 1948 3782 THYMU20120240 1813 1239 . .
. 3002 3783 THYMU20120730 1814 1257 . . . 2459 3784 THYMU20121040
1815 230 . . . 2323 3785 THYMU20128910 1816 181 . . . 1185 3786
THYMU20129020 1817 1545 . . . >2019 3787 THYMU20130470 1818 87 .
. . 1169 3788 THYMU20134260 1819 1845 . . . 2171 3789 THYMU20137050
1820 958 . . . 1341 3790 THYMU20137570 1821 2113 . . . 2571 3791
THYMU20139160 1822 69 . . . 686 3792 THYMU20140510 1823 1312 . . .
1626 3793 THYMU20143230 1824 575 . . . 2023 3794 THYMU20145990 1825
1330 . . . 2262 3795 THYMU20148010 1826 326 . . . 820 3796
THYMU20149230 1827 581 . . . 925 3797 THYMU20150190 1828 1516 . . .
1908 3798 THYMU20151610 1829 218 . . . 1663 3799 THYMU20153210 1830
1135 . . . 2340 3800 THYMU20154790 1831 1220 . . . 1753 3801
THYMU20157620 1832 771 . . . 1487 3802 THYMU20163600 1833 1216 . .
. 1650 3803 THYMU20170080 1834 944 . . . 1399 3804 THYMU20170230
1835 835 . . . 1941 3805 THYMU20171580 1836 821 . . . 1150 3806
THYMU20174490 1837 52 . . . 453 3807 THYMU20174790 1838 29 . . .
370 3808 THYMU20175260 1839 991 . . . 1452 3809 THYMU20176010 1840
12 . . . 2039 3810 THYMU20177070 1841 1059 . . . 1415 3811
THYMU20178440 1842 81 . . . 1517 3812 THYMU20181890 1843 102 . . .
1652 3813 THYMU20184550 1844 171 . . . 1886 3814 THYMU20185470 1845
161 . . . 817 3815 THYMU20185650 1846 36 . . . 536 3816
THYMU20187210 1847 190 . . . 507 3817 THYMU20191970 1848 230 . . .
1597 3818 TKIDN10000620 1849 1075 . . . 1419 3819 TKIDN10001710
1850 1685 . . . 2365 3820 TKIDN10001920 1851 98 . . . 793 3821
TRACH20011010 1852 228 . . . 2033 3822 TRACH20011540 1853 125 . . .
478 3823 TRACH20012490 1854 83 . . . 1600 3824 TRACH20021000 1855
234 . . . 854 3825 TRACH20021380 1856 313 . . . 1890 3826
TRACH20025370 1857 947 . . . 1456 3827 TRACH20026640 1858 964 . . .
1557 3828 TRACH20029880 1859 201 . . . 1607 3829 TRACH20040390 1860
125 . . . 3319 3830 TRACH20041090 1861 1254 . . . 1589 3831
TRACH20043360 1862 30 . . . 2066 3832 TRACH20044990 1863 209 . . .
790 3833 TRACH20049500 1864 840 . . . 1166 3834 TRACH20051590 1865
927 . . . 1247 3835 TRACH20057200 1866 2082 . . . 2393 3836
TRACH20058000 1867 187 . . . 1647 3837 TRACH20073990 1868 98 . . .
454 3838 TRACH20080810 1869 2073 . . . >2910 3839 TRACH20081270
1870 1681 . . . >2025 3840 TRACH20090060 1871 309 . . . 1781
3841 TRACH20091070 1872 129 . . . 1841 3842 TRACH20093400 1873 131
. . . 2251 3843 TRACH20093480 1874 694 . . . 1092 3844
TRACH20098510 1875 142 . . . 1944 3845 TRACH20101590 1876 1660 . .
. 2220 3846 TRACH20104510 1877 144 . . . 1184 3847 TRACH20108240
1878 36 . . . 791 3848 TRACH20113020 1879 177 . . . 1352 3849
TRACH20122980 1880 732 . . . 1562 3850 TRACH20123870 1881 235 . . .
540 3851 TRACH20124970 1882 109 . . . 486 3852 TRACH20125620 1883
22 . . . 387 3853 TRACH20129180 1884 1545 . . . 1898 3854
TRACH20131230 1885 123 . . . 2939 3855 TRACH20139280 1886 152 . . .
1474 3856 TRACH20140180 1887 203 . . . 553 3857 TRACH20143710 1888
1219 . . . 1998 3858 TRACH20149500 1889 163 . . . 906 3859
TRACH20149720 1890 187 . . . 1695 3860 TRACH20149740 1891 864 . . .
1505 3861 TRACH20158240 1892 254 . . . 796 3862 TRACH20159390 1893
1618 . . . 1941 3863 TRACH20160800 1894 1223 . . . 1531 3864
TRACH20163470 1895 971 . . . 2356 3865 TRACH20164100 1896 372 . . .
722 3866 TRACH20164810 1897 1685 . . . 2104 3867 TRACH20165330 1898
704 . . . 1102 3868 TRACH20165540 1899 810 . . . 1514 3869
TRACH20167090 1900 57 . . . 1148 3870 TRACH20170860 1901 186 . . .
1625 3871 TRACH20173680 1902 83 . . . 1597 3872 TRACH20174980 1903
93 . . . 1088 3873 TRACH20182780 1904 1669 . . . 2070 3874
TRACH20185120 1905 13 . . . 339 3875 TRACH20188350 1906 248 . . .
1015 3876 TRACH20190460 1907 351 . . . 1526 3877 UMVEN10001380 1908
2122 . . . 2436 3878 UTERU10001060 1909 187 . . . 552 3879
UTERU10001870 1910 1681 . . . 2031 3880 UTERU20000230 1911 120 . .
. 608 3881 UTERU20000950 1912 240 . . . 1658 3882 UTERU20011760
1913 1719 . . . 2090 3883 UTERU20013890 1914 1544 . . . 1951 3884
UTERU20016580 1915 25 . . . 1287 3885 UTERU20026620 1916 1020 . . .
1556 3886 UTERU20027360 1917 1624 . . . 1992 3887 UTERU20029930
1918 82 . . . 1902 3888 UTERU20031350 1919 35 . . . 520 3889
UTERU20035770 1920 920 . . . 1282 3890 UTERU20040150 1921 917 . . .
1717 3891 UTERU20040370 1922 22 . . . 1866 3892 UTERU20040390 1923
727 . . . 1200 3893 UTERU20040730 1924 1009 . . . >2303 3894
UTERU20041630 1925 105 . . . 1328 3895 UTERU20041970 1926 26 . . .
484 3896 UTERU20045200 1927 6 . . . 917 3897 UTERU20051790 1928 415
. . . 1341 3898 UTERU20064120 1929 147 . . . 1061 3899
UTERU20065470 1930 389 . . . 694 3900 UTERU20079240 1931 408 . . .
713 3901 UTERU20083020 1932 23 . . . 826 3902 UTERU20086530 1933
1274 . . . 1783 3903 UTERU20087070 1934 1274 . . . 2467 3904
UTERU20087850 1935 464 . . . 991 3905 UTERU20089300 1936 906 . . .
1253 3906 UTERU20089390 1937 11 . . . 1729 3907 UTERU20089620 1938
132 . . . 725 3908 UTERU20090940 1939 122 . . . 631 3909
UTERU20091470 1940 260 . . . 697 3910 UTERU20094830 1941 127 . . .
1578 3911 UTERU20095100 1942 1593 . . . 1913 3912 UTERU20099040
1943 59 . . . 883 3913 UTERU20099510 1944 705 . . . 2375 3914
UTERU20101150 1945 874 . . . 1188 3915 UTERU20102260 1946 270 . . .
671 3916 UTERU20103040 1947 1164 . . . 1772 3917 UTERU20103200 1948
374 . . . 709 3918 UTERU20104310 1949 90 . . . 425 3919
UTERU20106510 1950 1649 . . . 2275 3920 UTERU20121140 1951 880 . .
. 1644 3921 UTERU20122520 1952 572 . . . >2146 3922
UTERU20125810 1953 21 . . . 329 3923 UTERU20127030 1954 618 . . .
1763 3924 UTERU20127150 1955 707 . . . 1699 3925 UTERU20128560 1956
203 . . . 721 3926 UTERU20132620 1957 330 . . . 1007 3927
UTERU20134830 1958 121 . . . 1341 3928 UTERU20139760 1959 982 . . .
1659 3929 UTERU20140010 1960 42 . . . 368 3930 UTERU20167570 1961
57 . . . 710 3931 UTERU20168960 1962 317 . . . 1468 3932
UTERU20169020 1963 30 . . . 782 3933 UTERU20173030 1964 1985 . . .
>2355 3934 UTERU20176230 1965 1004 . . . 1372 3935 UTERU20177150
1966 3 . . . 350 3936 UTERU20181270 1967 153 . . . 620 3937
UTERU20185220 1968 521 . . . 1357 3938 UTERU20188670 1969 231 . . .
1886 3939 UTERU20188840 1970 1834 . . . 2181 3940
[0041] Namely, primers used to synthesize polynucleotides can be
designed based on the nucleotide sequences of polynucleotides of
the present invention shown in SEQ ID NOs in the above Table 1.
When one intends to synthesize full-length cDNAs, an oligo dT
primer can be used as the 3'-end primer. The length of the primers
is usually 15-100 bp, and favorably between 15-35 bp. In case of LA
PCR, which is described below, the primer length of 25-35 bp may
provide a good result.
[0042] A method to design a primer that enables a specific
amplification based on the aimed nucleotide sequence is known to
those skilled in the art (Current Protocols in Molecular Biology,
Ausubel et al. edit, (1987) John Wiley & Sons, Section
6.1-6.4). In designing a primer based on the 5'-end sequence, the
primer is designed so as that, in principle, the amplification
products will include the translation start site. Accordingly, for
example, when the 5'-end primer is designed based on the nucleotide
sequence of 5' untranslated region (5'UTR), any part of the 5'-end,
which ensures the specificity to the cDNA of interest, can be
selected as the primer.
[0043] When synthesizing a full-length cDNA, the target nucleotide
sequence to be amplified can extend to several thousand bp in some
cDNA. However, it is possible to amplify such a long nucleotides by
using such as LA PCR (Long and Accurate PCR). It is advantageous to
use LA PCR when synthesizing long DNA. In LA PCR, in which a
special DNA polymerase having 3'->5' exonuclease activity is
used, misincorporated nucleotides can be removed. Accordingly,
accurate synthesis of the complementary strand can be achieved even
with a long nucleotide sequence. By using LA PCR, it is reported
that amplification of a nucleotide with 20 kb longer can be
achieved under desirable conditions (Takeshi Hayashi (1996)
Jikken-Igaku Bessatsu, "Advanced Technologies in PCR"
Youdo-sha).
[0044] A template DNA for synthesizing the full-length cDNA of the
present invention can be obtained by using cDNA libraries that are
prepared by various methods. The full-length cDNA clones of the
present invention are clones with high probability of completeness
in length, which were obtained by the method comprising the steps
of [1] preparing libraries containing cDNAs with the very high
fullness ratio by oligo-capping, and [2] assembling the 5'-end
sequences and selecting one with the highest probability of
completeness in length in the cluster formed (there are many clones
longer in the 5'-end direction).
[0045] However, the uses of primers designed based on the
full-length nucleotide sequences provided by the present invention
enable easily obtaining full-length cDNAs without such a special
technique.
[0046] The problem with the cDNA libraries prepared by the known
methods or commercially available is that mRNA contained in the
libraries has very low fullness ratio. Thus, it is difficult to
screen full-length cDNA clone directly from the library using
ordinary cloning methods. The present invention has revealed a
nucleotide sequence of novel full-length cDNA. If a full-length
nucleotide sequence is provided, it is possible to synthesize a
target full-length cDNA by using enzymatic reactions such as PCR.
In particular, a full-length-enriched cDNA library, synthesized by
methods such as oligo-capping, is desirable to synthesize a
full-length cDNA with more reliability.
[0047] The 5'-end sequence of the full-length cDNA clones of the
invention can be used to isolate the regulatory element of
transcription including the promoter on the genome. A rough draft
of the human genome (analysis of human genomic sequence with lower
accuracy), which covers 90% of the genome, has been reported
(Nature, Vol. 409, 814-823, 2001), and by the year 2003, analysis
of the entire human genomic sequence is going to be finished.
However, it is hard to analyze with software the transcription
start sites on the human genome, in which long introns exist. By
contrast, it is easy to specify the transcription start site on the
genomic sequence using the nucleotide sequence which includes the
5'-end of the full-length cDNA clone of the present invention, and
thus it is easy to obtain the genomic region involved in
transcription regulation, which includes the promoter that is
contained in the upstream of the transcription start site.
[0048] The polypeptide encoded by the full-length cDNA of the
invention can be prepared as a recombinant polypeptide or as a
natural polypeptide. For example, the recombinant polypeptide can
be prepared by inserting the polynucleotide encoding the
polypeptide of the invention into a vector, introducing the vector
into an appropriate host cell and purifying the polypeptide
expressed within the transformed host cell, as described below. In
contrast, the natural polypeptide can be prepared, for example, by
utilizing an affinity column to which an antibody against the
polypeptide of the invention (Current Protocols in Molecular
Biology (1987) Ausubel et al. edit, John Wiley & Sons, Section
16.1-16.19) is attached. The antibody used for affinity
purification may be either a polyclonal antibody, or a monoclonal
antibody. Alternatively, in vitro translation (See, for example,
"On the fidelity of mRNA translation in the nuclease-treated rabbit
reticulocyte lysate system." Dasso M. C., and Jackson R. J. (1989)
Nucleic Acids Res. 17: 3129-3144) may be used for preparing the
polypeptide of the invention.
[0049] Polypeptides functionally equivalent to the polypeptides of
the present invention can be prepared based on the activities,
which were clarified in the above-mentioned manner, of the
polypeptides of the present invention. Using the biological
activity possessed by the polypeptide of the invention as an index,
it is possible to verify whether or not a particular polypeptide is
functionally equivalent to the polypeptide of the invention by
examining whether or not the polypeptide has said activity.
[0050] Polypeptides functionally equivalent to the polypeptides of
the present invention can be prepared by those skilled in the art,
for example, by using a method for introducing mutations into an
amino acid sequence of a polypeptide (for example, site-directed
mutagenesis (Current Protocols in Molecular Biology, edit, Ausubel
et al., (1987) John Wiley & Sons, Section 8.1-8.5) Besides,
such polypeptides can be generated by spontaneous mutations. The
present invention also includes a polypeptide comprising the amino
acid sequence shown in Table 1 in which one or more amino acids are
substituted, deleted, inserted, and/or added, as long as the
polypeptides have the equivalent functions to those of the
polypeptides identified in the present Examples described
later.
[0051] There are no limitations on the number and sites of amino
acid mutations, as long as the polypeptides maintain the functions
thereof. The number of mutations typically corresponds to 30% or
less, or 20% or less, or 10% or less, preferably 5% or less, or 3%
or less of the total amino acids, more preferably 2% or less or 1%
or less of the total amino acids. Alternatively, herein,
substitution of one or more amino acids includes substitution of
several amino acids. As used herein, the term "several amino acids"
means, for example, 5 amino acids, preferably 4 or 3 amino acids,
more preferably 2 amino acids, and further preferably 1 amino
acid.
[0052] From the viewpoint of maintaining the polypeptide function,
it is preferable that a substituted amino acid has a similar
property to that of the original amino acid. For example, Ala, Val,
Leu, Ile, Pro, Met, Phe and Trp are assumed to have similar
properties to one another because they are all classified into a
group of non-polar amino acids. Similarly, substitution can be
performed among non-charged amino acid such as Gly, Ser, Thr, Cys,
Tyr, Asn, and Gln, acidic amino acids such as Asp and Glu, and
basic amino acids such as Lys, Arg, and His.
[0053] In addition, polypeptides functionally equivalent to the
polypeptides of the present invention can be isolated by using
techniques of hybridization or gene amplification known to those
skilled in the art. Specifically, using the hybridization technique
(Current Protocols in Molecular Biology, edit, Ausubel et al.,
(1987) John Wiley & Sons, Section 6.3-6.4)), those skilled in
the art can usually isolate a polynucleotide highly homologous to
the polynucleotide encoding the polypeptide identified in the
present Example based on the identified nucleotide sequence (Table
1) or a portion thereof and obtain the functionally equivalent
polypeptide from the isolated polynucleotide. The present invention
include polypeptides encoded by the polynucleotides hybridizing
with the polynucleotides encoding the polypeptides identified in
the present Example, as long as the polypeptides are functionally
equivalent to the polypeptides identified in the present Example.
Organisms from which the functionally equivalent polypeptides are
isolated are illustrated by vertebrates such as human, mouse, rat,
rabbit, pig and bovine, but are not limited to these animals.
[0054] Washing conditions of hybridization for the isolation of
polynucleotides encoding the functionally equivalent polypeptides
are usually "1.times.SSC, 0.1% SDS, 37.degree. C."; more stringent
conditions are "0.5.times.SSC, 0.1% SDS, 42.degree. C."; and still
more stringent conditions are "0.1.times.SSC, 0.1% SDS, 65.degree.
C.". Alternatively, the following conditions can be given as
hybridization conditions of the present invention. Namely,
conditions in which the hybridization is done at "6.times.SSC, 40%
Formamide, 25.degree. C.", and the washing at "1.times.SSC,
55.degree. C." can be given. More preferable conditions are those
in which the hybridization is done at "6.times.SSC, 40% Formamide,
37.degree. C.", and the washing at "0.2.times.SSC, 55.degree. C.".
Even more preferable are those in which the hybridization is done
at "6.times.SSC, 50% Formamide, 37.degree. C.", and the washing at
"0.1.times.SSC, 62.degree. C.". The more stringent the conditions
of hybridization are, the more frequently the polynucleotides
highly homologous to the probe sequence are isolated. Therefore, it
is preferable to conduct hybridization under stringent conditions.
Examples of stringent conditions in the present invention are,
washing conditions of "0.5.times.SSC, 0.1% SDS, 42.degree. C.", or
alternatively, hybridization conditions of "6.times.SSC, 40%
Formamide, 37.degree. C.", and the washing at "0.2.times.SSC,
55.degree. C.".
[0055] One skilled in the art can suitably select various
conditions, such as dilution ratios of SSC, formamide
concentrations, and temperatures to accomplish a similar
stringency.
[0056] However, the above-mentioned combinations of SSC, SDS and
temperature conditions are indicated just as examples. Those
skilled in the art can select the hybridization conditions with
similar stringency to those mentioned above by properly combining
the above-mentioned or other factors (for example, probe
concentration, probe length and duration of hybridization reaction)
that determines the stringency of hybridization.
[0057] The amino acid sequences of polypeptides isolated by using
the hybridization techniques usually have high identity to those of
the polypeptides of the present invention, which are shown in Table
1. The present invention encompasses a polynucleotide comprising a
nucleotide sequence that has a high identity to the nucleotide
sequence of claim 1 (a). Furthermore, the present invention
encompasses a peptide, or polypeptide comprising an amino acid
sequence that has a high identity to the amino acid sequence
encoded by the polynucleotide of claim 1 (b). The term "high
identity" indicates sequence identity of at least 40% or more;
preferably 60% or more; and more preferably 70% or more.
Alternatively, more preferable is identity of 90% or more, or 93%
or more, or 95% or more, furthermore, 97% or more, or 99% or more.
The identity can be determined by using the BLAST search
algorithm.
[0058] As used herein, "percent identity" of amino acid sequences
or nucleic acids is determined using the algorithm BLAST of Karlin
and Altschul (Proc. Natl. Acad. Sci. USA 90:5873-5877, 1993). Such
an algorithm is incorporated into the BLASTN and BLASTX programs of
Altschul et al. (J. Mol. Biol. 215:403-410, 1990). BLAST nucleotide
searches are performed with the BLASTN program, for example,
score=100, wordlength=12. BLAST protein searches are performed with
the BLASTX program, for example, score=50, wordlength=3. When
utilizing BLAST and Gapped BLAST programs, the default parameters
of the respective programs are used. See
http://www.ncbi.nlm.nih.gov.
[0059] With the gene amplification technique (PCR) (Current
Protocols in Molecular Biology, edit, Ausubel et al., (1987) John
Wiley & Sons, Section 6.1-6.4)) using primers designed based on
the nucleotide sequence (Table 1) or a portion thereof identified
in the present Example, it is possible to isolate a polynucleotide
fragment highly homologous to the polynucleotide sequence or a
portion thereof and to obtain functionally equivalent polypeptide
to a particular polypeptide identified in the present Example based
on the isolated polynucleotide fragment.
[0060] The present invention also provides a polynucleotide
containing at least 15 nucleotides complementary to a
polynucleotide comprising a nucleotide sequence of SEQ ID NOs shown
in Table 1 or the complementary strand thereof. Herein, the term
"complementary strand" is defined as one strand of a double strand
DNA composed of A:T and G:C base pair to the other strand. Also,
"complementary" is defined as not only those completely matching
within a continuous region of at least 15 nucleotides, but also
having a identity of at least 70%, favorably 80% or higher, more
favorably 90% or higher, and most favorably 95% or higher within
that region. The identity may be determined using the algorithm
described herein.
[0061] Such a polynucleotide includes probes and primers used for
the detection and amplification of a polynucleotide encoding the
inventive polypeptide. When used as a primer, the polynucleotide
usually comprises 15 to 100 bp, and preferably of 15 to 35 bp. When
used as a probe, the polynucleotide comprises the whole or a part
of the sequence of a polynucleotide of the invention, and comprises
at least 15 bp. When used as primers, such polynucleotides are
complementary at the 3'-end, and restriction enzyme recognition
sequences or tags can be added to the 5'-end.
[0062] Furthermore, polynucleotides of the present invention
include an antisense polynucleotide for suppressing the expression
of a polypeptide of the invention, which comprises an amino acid
sequence of SEQ ID NOs shown in Table 1. To exert an antisense
effect, an antisense polynucleotide has at least 15 bp or more, for
example 50 bp or more, preferably 100 bp or more, and more
preferably 500 bp or more, and usually has 3000 bp or less, and
preferably 2000 bp or less. Antisense polynucleotides can be used
in the gene therapy of diseases caused by abnormalities of the
polypeptides of the invention (abnormal function or abnormal
expression). An antisense polynucleotide can be prepared, for
example, by the phosphorothioate method ("Physicochemical
properties of phosphorothioate oligodeoxynucleotides." Stein (1988)
Nucleic Acids Res. 16: 3209-3221) based on the sequence information
of polynucleotide encoding a polypeptide of the invention (for
example, the nucleotide sequences of SEQ ID NO: 1 to 1970).
[0063] The polynucleotides or antisense polynucleotides of the
present invention can be used in, for example, gene therapy. As
target diseases, for example, cancers or various inflammatory
diseases may be preferable. These molecules can be used for gene
therapy, for example, by administrating them to patients by the in
vivo or ex vivo method using virus vectors such as retrovirus
vectors, adenovirus vectors, and adeno-related virus vectors, or
non-virus vectors such as liposomes.
[0064] The present invention also includes a partial peptide of the
polypeptides of the invention. The partial peptide comprises a
polypeptide generated as a result that a signal peptide has been
removed from a secretory protein. If the polypeptide of the present
invention has an activity as a receptor or a ligand, the partial
peptide may function as a competitive inhibitor of the polypeptide
and may bind to the receptor (or ligand). In addition, the present
invention includes an antigen peptide for raising antibodies. For
the peptides to be specific for the polypeptide of the invention,
the peptides comprise at least 7 amino acids, preferably 8 amino
acids or more, more preferably 9 amino acids or more, and even more
preferably 10 amino acids or more. The peptide can be used for
preparing antibodies against the polypeptide of the invention, or
competitive inhibitors of them, and also screening for a receptor
that binds to the polypeptide of the invention. The partial
peptides of the invention can be produced, for example, by genetic
engineering methods, known methods for synthesizing peptides, or
digesting the polypeptide of the invention with an appropriate
peptidase.
[0065] The present invention also relates to a vector into which a
polynucleotide of the invention is inserted. The vector of the
invention is not limited as long as it contains the inserted
polynucleotide stably. For example, if E. coli is used as a host,
vectors such as pBluescript vector (Stratagene) are preferable as a
cloning vector. To produce the polypeptide of the invention,
expression vectors are especially useful. Any expression vector can
be used as long as it is capable of expressing the polypeptide in
vitro, in E. coli, in cultured cells, or in vivo. For example,
pBEST vector (Promega) is preferable for in vitro expression, pET
vector (Invitrogen) for E. coli, pME18S-FL3 vector (GenBank
Accession No. AB009864) for cultured cells, and pME18S vector (Mol.
Cell. Biol. (1988) 8: 466-472) for in vivo expression. To insert
the polynucleotide of the invention, ligation utilizing restriction
sites can be performed according to the standard method (Current
Protocols in Molecular Biology (1987) Ausubel et al. edit, John
Wiley & Sons, Section 11.4-11.11).
[0066] Recently, the technique of GATEWAY.TM. system (Invitrogen),
which is an expression vector construction system for polypeptide
expression, has been developed (Experimental Medicine, Vol. 18, No.
19 (December), p2716-2717, 2000). This system includes two types of
site-specific recombinases (BP CLONASE.TM. and LR CLONASE.TM.)
derived from lambda phage and uses BP CLONASE.TM.-specific
recombination sites for an Entry Vector and LR CLONASE.TM.-specific
recombination sites for a Destination Vector, which may comprise a
tag useful for polypeptide purification. With this system, an
expression vector can be obtained by using homologous
recombination.
[0067] First, a polynucleotide fragment of interest is inserted
into the entry vector using the first recombination. Then, the
secondary recombination is allowed to take place between the entry
vector, where the polynucleotide fragment of interest has been
inserted, and the destination vector. Thus, the expression vector
can be prepared rapidly and highly efficiently. With the
above-mentioned typical method using restriction enzyme and ligase
reactions, the step of expression vector construction and
expression of polypeptide of interest takes about 7 to 10 days.
However, with the GATEWAY.TM. system, the polypeptide of interest
can be expressed and prepared in only 3 to 4 days. Thus, the system
ensures a high-throughput functional analysis for expressed
polypeptides
(http://biotech.nikkeibp.co.jp/netlink/lto/gateway/).
[0068] The present invention also relates to a transformant
carrying the vector of the invention. Any cell can be used as a
host into which the vector of the invention is inserted, and
various kinds of host cells can be used depending on the purposes.
For strong expression of the polypeptide in eukaryotic cells, COS
cells or CHO cells can be used, for example.
[0069] Introduction of the vector into host cells can be performed,
for example, by calcium phosphate precipitation method,
electroporation method (Current Protocols in Molecular Biology
(1987) Ausubel et al. edit, John Wiley & Sons, Section
9.1-9.9), lipofectamine method (GIBCO-BRL), or microinjection
method, etc.
[0070] Further, a polynucleotide containing at least 15 nucleotides
comprising a nucleotide sequence of any one of the polynucleotides
comprising the nucleotide sequences of SEQ ID NOs shown in Table 1
or the complementary strand thereof can be used not only as a
primer for synthesizing full-length cDNAs but also for testing and
diagnosing the abnormalities of the polypeptide encoded by the
full-length cDNA of the present invention. For example, by
utilizing polymerase chain reaction (genomic DNA-PCR, or RT-PCR)
using the polynucleotide of the invention as a primer,
polynucleotide encoding the polypeptide of the invention can be
amplified. It is also possible to obtain the regulatory region of
expression in the 5'-upstream by using PCR or hybridization since
the transcription start site within the genomic sequence can be
easily specified based on the 5'-end sequence of the full-length
cDNA. The obtained genomic region can be used for detection and/or
diagnosis of the abnormality of the sequence by RFLP analysis,
SSCP, or sequencing. Especially, in the case where expression of
the mRNA of the present invention varies according to a specific
disease, analysis of the amount of expression of the mRNA using the
polynucleotide of the present invention as a probe or a primer
enables detection and diagnosis of the disease.
[0071] The present invention also relates to antibodies that bind
to the polypeptide of the invention. There are no limitations in
the form of the antibodies of the invention. They include
polyclonal antibodies, monoclonal antibodies, or their portions
that can bind to an antigen. They also include antibodies of all
classes. Furthermore, special antibodies such as humanized
antibodies and chimeric antibodies are also included.
[0072] The polyclonal antibody of the invention can be obtained
according to the standard method by synthesizing an oligopeptide
corresponding to the amino acid sequence and immunizing rabbits
with the peptide (Current Protocols in Molecular Biology (1987)
Ausubel et al. edit, John Wiley & Sons, Section 11.12-11.13).
The monoclonal antibody of the invention can be obtained according
to the standard method by purifying the polypeptide expressed in E.
coli, immunizing mice with the polypeptide, and producing a
hybridoma cell by fusing the spleen cells and myeloma cells
(Current Protocols in Molecular Biology (1987) Ausubel et al. edit,
John Wiley & Sons, Section 11.4-11.11).
[0073] The antibody binding to the polypeptide of the present
invention can be used for purification of the polypeptide of the
invention, and also for detection and/or diagnosis of the
abnormalities of the expression and structure of the polypeptide.
Specifically, polypeptides can be extracted, for example, from
tissues, blood, or cells, and the polypeptide of the invention is
detected by Western blotting, immunoprecipitation, or ELISA, etc.
for the above purpose.
[0074] Furthermore, the antibody binding to the polypeptide of the
present invention can be utilized for treating the diseases that
associates with the polypeptide of the invention. If the antibodies
are used for treating patients, human antibodies, humanized
antibodies, or chimeric antibodies are preferable in terms of their
low antigenicity. The human antibodies can be prepared by
immunizing a mouse whose immune system is replaced with that of
human (e.g., see "Functional transplant of megabase human
immunoglobulin loci recapitulates human antibody response in mice"
Mendez, M. J. et al. (1997) Nat. Genet. 15: 146-156). The humanized
antibodies can be prepared by recombination of the hypervariable
region of a monoclonal antibody (Methods in Enzymology (1991) 203:
99-121).
[0075] A cDNA of the present invention encodes, for example, an
amino acid sequence of a protein that is predicted to have the
following function. The use of the amino acid sequences of the
polypeptides encoded by the cDNAs of the present invention enables
predicting that the polypeptides have the following functions. It
can be predict, from the results of homology search of SwissProt,
GenBank, UniGene, or nr, that these polypeptides have such
functions. Specifically, for instance, as shown in Examples,
searching for a known gene or polypeptide that is homologous to the
partial sequence of the full-length cDNA of the invention (1970
clone) and referring the function of the gene and of the
polypeptide encoded by the gene make it possible to predict the
function of the polypeptide encoded by the cDNA of the invention.
In this way, each of 1078 clones out of the 1970 full-length cDNA
clones of the invention was predicted to encode a polypeptide that
was classified into the following categories. [0076] Secretory
and/or membrane protein (516 clones) [0077] Glycoprotein-related
protein (121 clones) [0078] Signal transduction-related protein (88
clones) [0079] Transcription-related protein (143 clones) [0080]
Disease-related protein (331 clones) [0081] Enzyme and/or
metabolism-related protein (219 clones) [0082] Cell division-
and/or cell proliferation-related protein (44 clones) [0083]
Cytoskeleton-related protein (80 clones) [0084] Nuclear protein
and/or RNA synthesis-related protein (70 clones) [0085] Protein
synthesis- and/or transport-related protein (20 clones) [0086]
Cellular defense-related protein (10 clones) [0087] Development
and/or differentiation-related protein (19 clones) [0088] DNA-
and/or RNA-binding protein (168 clones) [0089] ATP- and/or
GTP-binding protein (93 clones)
[0090] The functions of the polypeptides encoded by the cDNAs of
the present invention can be predicted by assessing the presence of
signal sequence, transmembrane region, nuclear translocation
signal, glycosylation signal, phosphorylation site, and zinc finger
motif, SH3 domain, etc. in the amino acid sequences. The programs,
PSORT (Nakai K., and Kanehisa M. (1992) Genomics 14: 897-911),
SOSUI (Hirokawa T. et al. (1998) Bioinformatics 14: 378-379)
(Mitsui Knowledge Industry), and MEMSAT (Jones D. T., Taylor W. R.,
and Thornton J. M. (1994) Biochemistry 33: 3038-3049) can be used
to predict the existence of the signal sequence or transmembrane
region. Alternatively, a partial amino acid sequence of the
polypeptide is fused with another polypeptide such as GFP, the
fusion polypeptide is transfected into cultured cells, and the
localization is analyzed to predict the function of the original
polypeptide.
[0091] Based on the determined nucleotide sequences of the
full-length cDNAs obtained in the present invention, it is possible
to predict more detailed functions of the polypeptides encoded by
the cDNA clones, for example, by searching the databases such as
GenBank, Swiss-Prot, UniGene, and nr for homologies of the cDNAs;
or by searching the amino acid sequences deduced from the
full-length cDNAs for signal sequences by using software programs
such as PSORT, for transmembrane regions by using software programs
such as SOSUI or for motifs by using software programs such as Pfam
(http://www.sanger.ac.uk/Software/Pfam/index.shtml) and PROSITE
(http://www.expasy.ch/prosite/). As a matter of course, the
functions are often predictable by using partial sequence
information (preferably 300 nucleotides or more) instead of the
full-length nucleotide sequences. However, the result of the
prediction by using partial nucleotide sequence does not always
agree with the result obtained by using full-length nucleotide
sequence, and thus, it is needless to say that the prediction of
function is preferably performed based on the full-length
nucleotide sequences.
[0092] GenBank, Swiss-Prot, UniGene and nr databases were searched
for homologies of the full-length nucleotide sequences of the 1970
clones (see Example 6). The amino acid sequences deduced from the
full-length nucleotide sequences were searched for functional
domains by PSORT, SOSUI and Pfam. Prediction of functions of
polypeptides encoded by the clones and the categorization thereof
were performed based on these results obtained. The categorization
was carried out by the following method.
[0093] [1] Firstly, the cDNA clones were classified into the
above-mentioned 14 functional categories based on the results of
annotation-based categorization (using the keywords in the case of
Swiss-Prot hit data; using Definition or Reference information in
the case of GenBank, UniGene, or nr hit data), and the signal
sequence search of the deduced ORFs by PSORT and the transmembrane
region search by SOSUI.
[0094] [2] Secondly, clones which had been unassignable to the
categories by the method of [1] were searched for functional
domains and/or motifs by Pfam. Based on the results, the clones
were additionally classified into the above-mentioned 14 types of
categories when they had a functional domain and/or motif
assignable to any one of the categories.
[0095] The following 516 clones presumably belong to secretory
and/or membrane proteins. TABLE-US-00002 ADRGL20020290,
ADRGL20021910, ADRGL20036380, ADRGL20036840, ADRGL20059610,
ADRGL20063770, ADRGL20066770, ASTRO20010010, ASTRO20020240,
ASTRO20045840, ASTRO20053430, ASTRO20055530, ASTRO20055570,
ASTRO20055930, ASTRO20088950, ASTRO20091180, BNGH420021680,
BNGH420023870, BNGH420046790, BNGH420052350, BNGH420059680,
BNGH420075940, BNGH420077980, BRACE10000510, BRACE20051930,
BRACE20052530, BRACE20054080, BRACE20066360, BRACE20068710,
BRACE20069000, BRACE20069110, BRACE20194670, BRACE20204670,
BRACE20216950, BRAMY10001730, BRAMY20003880, BRAMY20013670,
BRAMY20024790, BRAMY20027390, BRAMY20028530, BRAMY20035380,
BRAMY20044920, BRAMY20045210, BRAMY20047560, BRAMY20050940,
BRAMY20053910, BRAMY20055760, BRAMY20072440, BRAMY20083820,
BRAMY20089770, BRAMY20091230, BRAMY20094890, BRAMY20096930,
BRAMY20118410, BRAMY20123400, BRAMY20125550, BRAMY20127310,
BRAMY20127760, BRAMY20135720, BRAMY20137360, BRAMY20139440,
BRAMY20152510, BRAMY20194680, BRAMY20204270, BRAMY20225320,
BRAMY20237190, BRAMY20245140, BRAMY20251750, BRAMY20285650,
BRAWH20020470, BRAWH20021910, BRAWH20026010, BRAWH20030000,
BRAWH20039640, BRAWH20055330, BRAWH20078620, BRAWH20093070,
BRAWH20185270, BRCAN10000760, BRCAN10001680, BRCAN20001480,
BRCAN20004180, BRCAN20005230, BRCOC20000470, BRCOC20003600,
BRHIP10000720, BRHIP10001040, BRHIP20000210, BRSSN20001970,
BRSSN20074640, BRSSN20091190, CD34C20001750, CTONG20017490,
CTONG20036990, CTONG20041260, CTONG20044870, CTONG20045500,
CTONG20049480, CTONG20051450, CTONG20055850, CTONG20056150,
CTONG20059130, CTONG20060040, CTONG20063770, CTONG20065680,
CTONG20068360, CTONG20069320, CTONG20071680, CTONG20076810,
CTONG20078340, CTONG20079590, CTONG20083980, CTONG20084020,
CTONG20085210, CTONG20167750, CTONG20168240, CTONG20179890,
CTONG20183830, CTONG20184830, DFNES20018000, DFNES20029660,
DFNES20057660, DFNES20072990, DFNES20080880, FCBBF20018680,
FCBBF20029280, FCBBF20032930, FCBBF20036360, FCBBF20054390,
FCBBF30004340, FCBBF30022680, FCBBF30029250, FCBBF30042610,
FCBBF30062490, FCBBF30075970, FCBBF30078600, FCBBF30091520,
FCBBF30095410, FCBBF30105440, FCBBF30118670, FCBBF30132660,
FCBBF30135890, FCBBF30145670, FCBBF30164510, FCBBF30169870,
FCBBF30171230, FCBBF30172330, FCBBF30177290, FCBBF30179740,
FCBBF30195690, FCBBF30197840, FCBBF30212210, FCBBF30223110,
FCBBF30223210, FCBBF30225930, FCBBF30230610, FCBBF30260480,
FCBBF30266510, FCBBF30287940, FCBBF50000610, FCBBF50004950,
FEBRA20007820, FEBRA20018670, FEBRA20031280, FEBRA20031810,
FEBRA20038220, FEBRA20039260, FEBRA20040230, FEBRA20040560,
FEBRA20046280, FEBRA20080860, FEBRA20084750, FEBRA20088810,
FEBRA20115930, FEBRA20116650, FEBRA20121950, FEBRA20141980,
FEBRA20177800, FEBRA20182030, FEBRA20191720, HCHON10001660,
HCHON20015050, HEART10001490, HEART20031680, HHDPC10001140,
HHDPC20051850, HHDPC20082790, HHDPC20088160, HLUNG20015070,
HLUNG20015180, HLUNG20020850, HLUNG20029490, HLUNG20032460,
HLUNG20033350, HLUNG20034970, HLUNG20037160, HLUNG20041540,
HLUNG20042730, HLUNG20050760, HLUNG20052300, HLUNG20060670,
HLUNG20065990, HLUNG20074330, HLUNG20081390, HLUNG20088750,
HLUNG20092530, KIDNE20016360, KIDNE20083150, KIDNE20084030,
KIDNE20084040, KIDNE20084800, KIDNE20086490, KIDNE20086660,
KIDNE20094670, KIDNE20134130, KIDNE20142900, KIDNE20143200,
KIDNE20148080, KIDNE20160960, KIDNE20163710, KIDNE20169180,
KIDNE20182540, KIDNE20186170, KIDNE20188630, KIDNE20189960,
LIVER20007750, LIVER20010510, LIVER20010990, LIVER20026440,
LIVER20030650, LIVER20038000, MESAN20007110, MESAN20008150,
MESAN20021220, MESAN20027900, MESAN20058110, MESAN20059570,
MESAN20060430, MESAN20067430, MESAN20084150, MESAN20095220,
NT2NE20018740, NT2NE20021860, NT2NE20039210, NT2NE20053230,
NT2NE20059210, NT2NE20064780, NT2NE20069580, NT2NE20080770,
NT2NE20082130, NT2NE20092950, NT2NE20140130, NT2NE20145250,
NT2NE20146510, NT2NE20152620, NT2NE20167660, NT2NE20181800,
NT2RI20016240, NT2RI20021200, NT2RI20033920, NT2RP70003110,
NT2RP70027790, NT2RP70031070, NT2RP70031480, NT2RP70056690,
NT2RP70087140, NTONG20034540, NTONG20053630, OCBBF20000740,
OCBBF20012520, OCBBF20109780, OCBBF20110210, OCBBF20110730,
OCBBF20112280, OCBBF20118720, OCBBF20120010, OCBBF20123200,
OCBBF20155030, OCBBF20165900, OCBBF20165910, OCBBF20170350,
OCBBF20176650, OCBBF20185630, OCBBF20191950, PANCR10000860,
PEBLM20001800, PLACE50001290, PLACE60004260, PLACE60006300,
PLACE60053280, PLACE60055590, PLACE60056910, PLACE60057860,
PLACE60061370, PLACE60064740, PLACE60070500, PLACE60087680,
PLACE60104630, PLACE60107010, PLACE60113340, PLACE60138840,
PLACE60154450, PLACE60184870, PROST10001100, PROST20011160,
PROST20014150, PROST20035830, PROST20045700, PROST20050390,
PROST20065100, PROST20073280, PROST20082430, PROST20084680,
PROST20084720, PROST20099090, PROST20105450, PROST20106060,
PROST20108850, PROST20110120, PROST20114100, PROST20146590,
PROST20152510, PROST20168600, PUAEN10000870, SKMUS20006790,
SKMUS20020770, SKMUS20073150, SKMUS20091900, SKNMC20006350,
SKNSH20094350, SMINT20006090, SMINT20008110, SMINT20024140,
SMINT20028840, SMINT20045470, SMINT20077960, SMINT20081330,
SMINT20086250, SMINT20088440, SMINT20088690, SMINT20092160,
SPLEN20015100, SPLEN20017610, SPLEN20017810, SPLEN20024190,
SPLEN20024620, SPLEN20054500, SPLEN20058180, SPLEN20063890,
SPLEN20073880, SPLEN20080070, SPLEN20090880, SPLEN20101950,
SPLEN20104690, SPLEN20105100, SPLEN20108000, SPLEN20110180,
SPLEN20110860, SPLEN20118050, SPLEN20121790, SPLEN20125230,
SPLEN20136700, SPLEN20138600, SPLEN20139100, SPLEN20175920,
SPLEN20177400, SPLEN20182850, SPLEN20183020, SPLEN20183950,
SPLEN20190080, SPLEN20190770, SPLEN20193230, SPLEN20193490,
SPLEN20193790, SPLEN20201830, SPLEN20204670, TESOP10000350,
TESTI10000190, TESTI20006160, TESTI20029100, TESTI20031310,
TESTI20032770, TESTI20038240, TESTI20043130, TESTI20043220,
TESTI20045390, TESTI20046540, TESTI20046870, TESTI20047370,
TESTI20050400, TESTI20051200, TESTI20051730, TESTI20053260,
TESTI20053780, TESTI20057200, TESTI20057590, TESTI20059080,
TESTI20061200, TESTI20062120, TESTI20063330, TESTI20063410,
TESTI20063600, TESTI20066330, TESTI20068530, TESTI20070400,
TESTI20070740, TESTI20073460, TESTI20086840, TESTI20095200,
TESTI20095440, TESTI20095880, TESTI20100090, TESTI20102390,
TESTI20105910, TESTI20113940, TESTI20116120, TESTI20121040,
TESTI20121710, TESTI20131440, TESTI20142540, TESTI20149880,
TESTI20151800, TESTI20162780, TESTI20170170, TESTI20173050,
TESTI20182760, TESTI20183680, TESTI20184750, TESTI20186110,
TESTI20198540, TESTI20199110, TESTI20202830, TESTI20204260,
TESTI20210030, TESTI20214630, TESTI20219110, TESTI20244730,
TESTI20245600, TESTI20245860, TESTI20246410, TESTI20251610,
TESTI20257910, TESTI20260640, TESTI20261040, TESTI20262150,
TESTI20262940, TESTI20264910, TESTI20271790, TESTI20278280,
TESTI20282420, TESTI20282900, TESTI20286590, THYMU20007020,
THYMU20012020, THYMU20017270, THYMU20020800, THYMU20025480,
THYMU20028150, THYMU20030690, THYMU20034790, THYMU20046350,
THYMU20046770, THYMU20050010, THYMU20052830, THYMU20054800,
THYMU20055740, THYMU20055760, THYMU20062770, THYMU20078240,
THYMU20079690, THYMU20083390, THYMU20087270, THYMU20100940,
THYMU20115380, THYMU20137050, THYMU20137570, THYMU20143230,
THYMU20150190, THYMU20153210, THYMU20154790, THYMU20163600,
THYMU20171580, THYMU20178440, THYMU20185470, TRACH20011010,
TRACH20011540, TRACH20021380, TRACH20073990, TRACH20081270,
TRACH20090060, TRACH20149720, TRACH20149740, TRACH20159390,
TRACH20163470, TRACH20165330, TRACH20167090, TRACH20173680,
TRACH20190460, UMVEN10001380, UTERU20035770, UTERU20040150,
UTERU20045200, UTERU20064120, UTERU20086530, UTERU20087070,
UTERU20087850, UTERU20089300, UTERU20089620, UTERU20095100,
UTERU20099040, UTERU20103200, UTERU20125810, UTERU20127030,
UTERU20127150, UTERU20139760, UTERU20188840
[0096] The following 121 clones presumably belong to
glycoprotein-related proteins. TABLE-US-00003 ADRGL20020290,
ADRGL20036840, ADRGL20059610, ADRGL20066770, ASTRO20055570,
BNGH420046790, BNGH420077980, BRACE20051930, BRACE20069000,
BRACE20204670, BRACE20216950, BRAMY20013670, BRAMY20089770,
BRAMY20251210, BRAWH20039640, BRCAN10000760, BRCAN20005230,
BRCOC20003600, CD34C20001750, CTONG20017490, CTONG20036990,
CTONG20045500, CTONG20059130, CTONG20079590, CTONG20085210,
CTONG20184830, DFNES20018000, DFNES20080880, FCBBF30004340,
FCBBF30029250, FCBBF30062490, FCBBF30091520, FCBBF30164510,
FCBBF30171230, FCBBF30195690, FCBBF30223210, FEBRA20038220,
HCHON20015050, HLUNG20015070, HLUNG20032460, HLUNG20037160,
HLUNG20041540, KIDNE20142900, KIDNE20169180, KIDNE20186170,
KIDNE20189960, MESAN20021220, MESAN20058110, NT2NE20064780,
NT2NE20140130, NT2NE20155650, NT2RP70056690, NTONG20053630,
OCBBF20000740, OCBBF20012520, OCBBF20110210, OCBBF20120010,
OCBBF20165900, OCBBF20165910, OCBBF20191950, PEBLM20001800,
PLACE60004260, PLACE60087680, PLACE60113340, PLACE60184870,
PROST20033240, PROST20099090, PROST20108850, PROST20146590,
SKMUS20073150, SKNMC20006350, SMINT20028840, SMINT20056230,
SMINT20083290, SMINT20091190, SPLEN20024620, SPLEN20063890,
SPLEN20080070, SPLEN20090880, SPLEN20118050, SPLEN20139100,
SPLEN20183020, SPLEN20201830, TESTI10000190, TESTI20031310,
TESTI20043990, TESTI20045390, TESTI20051200, TESTI20057590,
TESTI20059080, TESTI20066330, TESTI20086840, TESTI20100090,
TESTI20105910, TESTI20154370, TESTI20164210, TESTI20182760,
TESTI20184750, TESTI20199110, TESTI20219110, TESTI20220230,
TESTI20245600, TESTI20251610, TESTI20257910, TESTI20286590,
THYMU20024500, THYMU20028150, THYMU20052830, THYMU20062770,
THYMU20099060, THYMU20170080, THYMU20178440, TRACH20011010,
TRACH20011540, TRACH20021380, TRACH20149740, TRACH20170860,
TRACH20190460, UTERU20086530, UTERU20087070, UTERU20127030
[0097] The following 88 clones presumably belong to signal
transduction-related proteins. TABLE-US-00004 ASTRO20050810,
ASTRO20052420, ASTRO20085080, ASTRO20090680, BNGH420008150,
BNGH420015760, BNGH420035290, BNGH420086030, BRAMY20035830,
BRAMY20043630, BRAMY20118490, BRAMY20206340, BRAMY20244490,
BRAMY20251210, BRAMY20263000, BRAWH20093040, BRAWH20190550,
CTONG20004520, CTONG20029030, CTONG20030280, CTONG20063930,
CTONG20070720, CTONG20189000, FCBBF30001100, FCBBF30076310,
FCBBF30100080, FCBBF30143550, FCBBF30153170, FCBBF30175350,
FCBBF30250980, FEBRA20090160, FEBRA20173330, HCHON20000870,
HLUNG20011260, HLUNG20084790, KIDNE20089870, KIDNE20160360,
LIVER20011640, MESAN20021130, MESAN20027240, MESAN20065990,
NT2NE20018890, NT2NE20042550, NT2R270075800, NTONG20043080,
NTONG20048440, PLACE60071800, PROST20033240, PROST20052850,
PROST20065790, PROST20075280, SKNSH20052400, SKNSH20057920,
SMINT20006020, SMINT20035050, SPLEN20023540, SPLEN20039180,
SPLEN20048800, SPLEN20049840, SPLEN20054160, SPLEN20085910,
SPLEN20191020, SPLEN20198390, TESTI20046490, TESTI20049060,
TESTI20053070, TESTI20066650, TESTI20081890, TESTI20095770,
TESTI20106820, TESTI20112860, TESTI20145780, TESTI20150420,
TESTI20168880, TESTI20205250, TESTI20228120, TESTI20244220,
TESTI20244460, TESTI20251740, TESTI20261160, TESTI20264530,
THYMU20013250, THYMU20039320, THYMU20106990, THYMU20145990,
THYMU20170080, THYMU20176010, TRACH20188350
[0098] The following 143-clones presumably belong to
transcription-related proteins. TABLE-US-00005 ASTRO20038400,
ASTRO20075150, BNGH420070370, BNGH420074600, BNGH420087430,
BRACE20003310, BRACE20061620, BRAMY20001510, BRAMY20040580,
BRAMY20076100, BRAMY20111780, BRAWH20040680, BRAWH20050740,
BRAWH20080580, BRAWH20082920, BRAWH20095900, BRSSN20066440,
CTONG20020950, CTONG20044230, CTONG20053990, CTONG20072930,
CTONG20074000, CTONG20084660, CTONG20186370, CTONG20186520,
DFNES20028170, DFNES20046840, DFNES20073320, FCBBF30003610,
FCBBF30019140, FCBBF30021900, FCBBF30093170, FCBBF30114850,
FCBBF30129010, FCBBF30136230, FCBBF30143550, FCBBF30220050,
FCBBF30228940, FCBBF30263080, FCBBF30285930, FCBBF50003530,
FEBRA20026820, FEBRA20027070, FEBRA20046510, FEBRA20057010,
FEBRA20063720, FEBRA20170240, HCHON10000150, HCHON20002650,
HEART20019310, HLUNG20014590, HLUNG20028110, HLUNG20063700,
KIDNE20140870, LIVER20006260, MESAN20016270, MESAN20038520,
NT2NE20038870, NT2NE20053950, NT2NE20060750, NT2NE20061030,
NT2NE20079670, NT2NE20082600, NT2RP70001120, NT2RP70029780,
NT2RP70046410, NT2RP70057500, NT2RP70075300, NT2RP70090870,
OCBBF20116250, OCBBF20120950, OCBBF20121910, OCBBF20156450,
OCBBF20157970, OCBBF20166900, OCBBF20175360, OCBBF20177540,
PEBLM20003260, PLACE60052940, PLACE60066970, PLACE60122970,
PLACE60150510, PLACE60177880, PROST20007170, PROST20024250,
PROST20035170, PROST20127450, PROST20151370, PROST20155370,
PUAEN10000650, PUAEN20003120, SMINT20011950, SMINT20026200,
SMINT20030740, SMINT20039050, SMINT20044140, SMINT20086720,
SPLEN20042200, SPLEN20043680, SPLEN20055600, SPLEN20059270,
SPLEN20063250, SPLEN20098030, SPLEN20197930, TESTI10001570,
TESTI20057430, TESTI20057840, TESTI20059810, TESTI20067480,
TESTI20068790, TESTI20075240, TESTI20079220, TESTI20088840,
TESTI20104090, TESTI20122070, TESTI20166670, TESTI20171070,
TESTI20173960, TESTI20184760, TESTI20194880, TESTI20197600,
TESTI20228740, TESTI20254030, TESTI20254990, TESTI20266050,
TESTI20274960, TESTI20282530, THYMU10004280, THYMU20019260,
THYMU20032820, THYMU20071120, THYMU20077250, TKIDN10001920,
UTERU20016580, UTERU20026620, UTERU20041630, UTERU20094830,
UTERU20099510, UTERU20101150, UTERU20169020, UTERU20177150,
UTERU20185220, UTERU20188670
[0099] The following 331 clones presumably belong to
disease-related proteins. TABLE-US-00006 ADRGL20020290,
ADRGL20021910, ADRGL20026790, ADRGL20036840, ADRGL20059610,
ADRGL20066770, ASTRO20038400, ASTRO20052420, ASTRO20055570,
ASTRO20075150, ASTRO20088950, BNGH420008150, BNGH420086030,
BRACE10000510, BRACE20003310, BRACE20069000, BRACE20097540,
BRACE20194670, BRACE20196180, BRACE20204670, BRACE20216950,
BRAMY20003540, BRAMY20005080, BRAMY20035830, BRAMY20040580,
BRAMY20043630, BRAMY20044920, BRAMY20051820, BRAMY20056620,
BRAMY20089770, BRAMY20111780, BRAMY20152510, BRAMY20190550,
BRAMY20221600, BRAMY20227860, BRAMY20274510, BRAWH20082920,
BRAWH20093040, BRAWH20095900, BRAWH20190530, BRAWH20191980,
BRCAN10000760, BRCAN10001050, BRCAN20005230, BRSSN20066440,
CTONG20004520, CTONG20029030, CTONG20042640, CTONG20045500,
CTONG20052780, CTONG20053990, CTONG20070780, CTONG20070910,
CTONG20072930, CTONG20083980, CTONG20084660, CTONG20165750,
CTONG20169040, CTONG20183430, CTONG20183830, CTONG20186290,
CTONG20189000, DFNES20016470, DFNES20025500, DFNES20046840,
DFNES20055400, DFNES20080880, FCBBF10000230, FCBBF20035490,
FCBBF20066340, FCBBF30002270, FCBBF30002280, FCBBF30019140,
FCBBF30053300, FCBBF30071500, FCBBF30072440, FCBBF30076310,
FCBBF30080730, FCBBF30100080, FCBBF30115920, FCBBF30118670,
FCBBF30129010, FCBBF30132050, FCBBF30136230, FCBBF30153170,
FCBBF30164510, FCBBF30166220, FCBBF30171230, FCBBF30175350,
FCBBF30194550, FCBBF30220050, FCBBF30223210, FCBBF30259050,
FCBBF30263080, FCBBF30275590, FCBBF50001650, FEBRA20027070,
FEBRA20045380, FEBRA20046200, FEBRA20046510, FEBRA20057010,
FEBRA20063720, FEBRA20078800, FEBRA20087550, FEBRA20088810,
FEBRA20090160, FEBRA20092760, FEBRA20151750, FEBRA20170240,
FEBRA20173330, FEBRA20191720, HCHON10000150, HCHON20015050,
HEART20009590, HEART20022200, HEART20063100, HHDPC20081230,
HLUNG20008460, HLUNG20014590, HLUNG20032460, HLUNG20063700,
HLUNG20065990, HLUNG20069350, HLUNG20081530, HLUNG20082350,
HLUNG20083330, HLUNG20085210, KIDNE20081170, KIDNE20084040,
KIDNE20088240, KIDNE20089870, KIDNE20133460, KIDNE20134890,
KIDNE20141700, KIDNE20142900, KIDNE20150730, KIDNE20152440,
KIDNE20160360, KIDNE20165390, KIDNE20169180, KIDNE20173430,
KIDNE20189960, LIVER20026440, MESAN20006200, MESAN20021130,
MESAN20033220, MESAN20056890, MESAN20057240, MESAN20065990,
MESAN20067430, MESAN20069530, NESOP20004520, NT2NE20018890,
NT2NE20026200, NT2NE20037050, NT2NE20053950, NT2NE20061030,
NT2NE20111190, NT2NE20117580, NT2NE20119980, NT2NE20140130,
NT2NE20141040, NT2RI20093010, NT2RP70003110, NT2RP70046410,
NT2RP70075300, NTONG20032100, NTONG20034540, OCBBF20000740,
OCBBF20012520, OCBBF20111600, OCBBF20120010, OCBBF20156450,
OCBBF20157970, OCBBF20191950, PEBLM20001800, PEBLM20003260,
PLACE60004260, PLACE60012620, PLACE60054230, PLACE60054870,
PLACE60062660, PLACE60087680, PLACE60184870, PROST20015210,
PROST20024250, PROST20036350, PROST20050390, PROST20058860,
PROST20063430, PROST20065790, PROST20084720, PROST20099090,
PROST20120070, PROST20127450, PROST20146590, PROST20152510,
PROST20168600, PUAEN10000650, PUAEN20003120, SKMUS20008730,
SKMUS20017400, SKMUS20040440, SKMUS20073590, SKMUS20079150,
SKNSH20009710, SMINT20002320, SMINT20007470, SMINT20008110,
SMINT20011950, SMINT20016150, SMINT20026200, SMINT20030740,
SMINT20049920, SMINT20077960, SMINT20083290, SMINT20086250,
SMINT20089600, SMINT20091190, SPLEN20023540, SPLEN20024190,
SPLEN20042200, SPLEN20043680, SPLEN20055600, SPLEN20057830,
SPLEN20059270, SPLEN20063890, SPLEN20073500, SPLEN20080070,
SPLEN20085910, SPLEN20090880, SPLEN20098030, SPLEN20118050,
SPLEN20136730, SPLEN20138600, SPLEN20139100, SPLEN20139360,
SPLEN20180980, SPLEN20187490, SPLEN20193790, SPLEN20201830,
TESTI10000190, TESTI20031310, TESTI20035790, TESTI20041630,
TESTI20049060, TESTI20050720, TESTI20051200, TESTI20057430,
TESTI20057590, TESTI20059080, TESTI20062120, TESTI20067480,
TESTI20071630, TESTI20099350, TESTI20105130, TESTI20105910,
TESTI20108060, TESTI20125920, TESTI20130530, TESTI20131440,
TESTI20134680, TESTI20142540, TESTI20143180, TESTI20150420,
TESTI20154370, TESTI20164210, TESTI20166670, TESTI20168880,
TESTI20171070, TESTI20182760, TESTI20184750, TESTI20193080,
TESTI20194880, TESTI20196970, TESTI20197600, TESTI20201760,
TESTI20207170, TESTI20219110, TESTI20228740, TESTI20244430,
TESTI20246480, TESTI20251740, TESTI20252690, TESTI20254030,
TESTI20257910, TESTI20258720, TESTI20266050, TESTI20271790,
TESTI20274960, TESTI20282530, TESTI20286590, THYMU10004280,
THYMU20006020, THYMU20013250, THYMU20019260, THYMU20023560,
THYMU20028150, THYMU20032820, THYMU20034400, THYMU20055460,
THYMU20063650, THYMU20070250, THYMU20071120, THYMU20081110,
THYMU20090230, THYMU20095920, THYMU20098350, THYMU20099060,
THYMU20120730, THYMU20121040, THYMU20170080, THYMU20185650,
THYMU20191970, TKIDN10000620, TKIDN10001920, TRACH20011540,
TRACH20091070, TRACH20143710, TRACH20170860, UTERU10001060,
UTERU20026620, UTERU20041630, UTERU20086530, UTERU20087070,
UTERU20087850, UTERU20099510, UTERU20101150, UTERU20104310,
UTERU20127030, UTERU20185220
[0100] The following 219 clones presumably belong to the category
of enzymes and/or metabolism-related proteins. TABLE-US-00007
ADRGL20059610, ASTRO20026320, ASTRO20050810, ASTRO20088950,
BNGH420008150, BNGH420035290, BNGH420074600, BRACE20050870,
BRACE20097540, BRACE20200770, BRACE20204670, BRACE20215410,
BRAMY20003540, BRAMY20005080, BRAMY20027990, BRAMY20028620,
BRAMY20044920, BRAMY20055760, BRAMY20056620, BRAMY20072870,
BRAMY20093490, BRAMY20096930, BRAMY20118490, BRAMY20125360,
BRAMY20143870, BRAMY20152510, BRAMY20231150, BRAMY20244490,
BRAMY20251210, BRAWH20021910, BRAWH20082920, BRAWH20093040,
BRAWH20094900, BRAWH20183170, BRAWH20188750, BRAWH20190550,
BRAWH20191980, BRCAN20005230, BRCOC20003600, CTONG20051100,
CTONG20070910, CTONG20076810, CTONG20079590, CTONG20080140,
CTONG20085210, CTONG20186290, DFNES20063460, DFNES20080880,
FCBBF20023490, FCBBF20066340, FCBBF30004340, FCBBF30019140,
FCBBF30022680, FCBBF30029250, FCBBF30072440, FCBBF30076310,
FCBBF30085560, FCBBF30091520, FCBBF30107290, FCBBF30125880,
FCBBF30132050, FCBBF30143550, FCBBF30153170, FCBBF30166220,
FCBBF30171230, FCBBF30175350, FCBBF30236670, FCBBF30260480,
FEBRA20038220, FEBRA20040560, FEBRA20078800, FEBRA20090160,
FEBRA20172230, FEBRA20173330, HCHON20000870, HCHON20002710,
HEART10001490, HEART20022200, HEART20047640, HEART20082570,
HLUNG20011260, HLUNG20032460, HLUNG20041540, HLUNG20042730,
HLUNG20054790, KIDNE20080690, KIDNE20083620, KIDNE20084040,
KIDNE20147170, KIDNE20152440, KIDNE20173150, KIDNE20186170,
KIDNE20189960, LIVER20011640, LIVER20026440, LIVER20055270,
MESAN20021130, MESAN20033220, MESAN20038520, MESAN20057240,
MESAN20058110, MESAN20065990, MESAN20095800, NT2NE20026200,
NT2NE20042550, NT2NE20117580, NT2NE20127900, NT2RI20093010,
NT2RP70064570, NTONG20034540, NTONG20043080, NTONG20053630,
NTONG20053730, NTONG20058010, OCBBF20120010, OCBBF20167290,
OCBBF20191950, PANCR10000860, PLACE60052940, PLACE60064180,
PLACE60073090, PLACE60095600, PLACE60184410, PLACE60188630,
PROST20007600, PROST20033240, PROST20036350, PROST20039300,
PROST20050390, PROST20051310, PROST20052850, PROST20065790,
PROST20075280, PROST20084720, PROST20099090, PROST20108850,
PROST20152510, PUAEN20001520, PUAEN20002470, SKNMC20006350,
SKNSH20057920, SMINT20008110, SMINT20049920, SMINT20094680,
SPLEN20023540, SPLEN20024930, SPLEN20043680, SPLEN20048800,
SPLEN20054500, SPLEN20057900, SPLEN20071820, SPLEN20080070,
SPLEN20085910, SPLEN20108000, SPLEN20136730, SPLEN20180980,
TESTI20012080, TESTI20030200, TESTI20031310, TESTI20038240,
TESTI20050720, TESTI20051200, TESTI20059080, TESTI20062120,
TESTI20066330, TESTI20076570, TESTI20103690, TESTI20105130,
TESTI20106820, TESTI20108060, TESTI20112860, TESTI20121040,
TESTI20130530, TESTI20131440, TESTI20168880, TESTI20170170,
TESTI20196690, TESTI20196970, TESTI20199110, TESTI20205250,
TESTI20212970, TESTI20222030, TESTI20226520, TESTI20227380,
TESTI20244460, TESTI20244730, TESTI20250630, TESTI20260640,
TESTI20262940, TESTI20264530, TESTI20285230, THYMU20006020,
THYMU20013250, THYMU20034400, THYMU20039320, THYMU20055460,
THYMU20055760, THYMU20063650, THYMU20066660, THYMU20070250,
THYMU20087270, THYMU20096580, THYMU20100940, THYMU20110720,
THYMU20120240, THYMU20120730, THYMU20170230, TRACH20011010,
TRACH20021380, TRACH20091070, TRACH20113020, TRACH20143710,
TRACH20164100, TRACH20190460, UTERU20087070, UTERU20089620,
UTERU20104310, UTERU20185220, UTERU20188670
[0101] The following 44 clones presumably belong to the category of
cell division- and/or cell proliferation-related proteins.
TABLE-US-00008 ASTRO20090680, BRACE20079370, BRAMY20234820,
BRCAN10001050, BRCAN20005410, CTONG20032930, FCBBF20070950,
FCBBF30002270, FCBBF30053300, FCBBF30105860, FCBBF30175350,
FCBBF30215240, FCBBF30275590, FEBRA20045380, HLUNG20068120,
KIDNE20134890, KIDNE20150730, MESAN20021470, NT2NE20077250,
NT2NE20153620, NT2RP70030840, NTONG20053910, OCBBF20111370,
OCBBF20174580, PROST20063430, SKNMC10001230, SMINT20028800,
SPLEN20023540, SPLEN20057830, SPLEN20139360, TESTI20031410,
TESTI20057840, TESTI20065650, TESTI20066650, TESTI20107320,
TESTI20108060, TESTI20114480, TESTI20134680, TESTI20143180,
TESTI20150920, TESTI20201760, TESTI20278280, TESTI20284260,
THYMU20097920
[0102] The following 80 clones presumably belong to the category of
cytoskeleton-related proteins. TABLE-US-00009 ADRGL20062330,
ASTRO20053430, BGGI120000670, BRACE20079370, BRAMY20038980,
BRAMY20083330, BRAMY20094890, CTONG20004110, CTONG20032930,
CTONG20077760, CTONG20083980, CTONG20169040, CTONG20183430,
DFNES20018000, FCBBF30105860, FCBBF30130410, FCBBF30194550,
FCBBF30201630, FCBBF30271990, FEBRA20005040, FEBRA20046200,
FEBRA20099860, HCHON20015050, HLUNG20081530, KIDNE20081170,
NT2RP70001730, NT2RP70003110, NTONG20032100, OCBBF20166890,
OCBBF20174890, PLACE60054870, PLACE60055590, PLACE60071800,
PLACE60118810, PROST20015210, PROST20097840, PROST20120070,
PROST20146590, SKMUS20007260, SKMUS20008730, SKMUS20017400,
SKMUS20073590, SMINT20062050, SMINT20074330, SMINT20077960,
SPLEN20039180, SPLEN20049840, SPLEN20076470, SPLEN20182990,
SPLEN20187490, SPLEN20195710, TESTI10000190, TESTI20041630,
TESTI20057880, TESTI20058920, TESTI20060080, TESTI20064530,
TESTI20064650, TESTI20065650, TESTI20067440, TESTI20071130,
TESTI20099350, TESTI20112540, TESTI20125280, TESTI20136010,
TESTI20153310, TESTI20175370, TESTI20222460, TESTI20244430,
TESTI20254030, TESTI20258720, THYMU20024500,THYMU20062610,
THYMU20098350, TRACH20043360, TRACH20098510, TRACH20149500,
UTERU20089390, UTERU20122520, UTERU20168960
[0103] The following 70 clones presumably belong to the category of
nuclear proteins and/or RNA synthesis-related proteins.
TABLE-US-00010 ASTRO20026320, BRACE20050870, BRACE20200770,
BRAMY20134050, BRAWH20063010, BRAWH20093040, BRAWH20174330,
BRAWH20176850, CTONG20042640, FCBBF20023490, FCBBF20035490,
FCBBF20070950, FCBBF30002270, FCBBF30048420, FCBBF30080730,
FCBBF30115920, FCBBF30236670, FEBRA20035240, FEBRA20092760,
FEBRA20173330, HHDPC20081230, HLUNG20011460, HLUNG20068120,
KIDNE20089870, KIDNE20150730, MESAN20056890, MESAN20057240,
NT2NE20037050, NT2NE20167660, NT2RP70031070, NTONG20053730,
PLACE60064180, PLACE60095600, PROST20016760, PROST20051310,
PROST20058860, PROST20152510, PUAEN20002470, SKMUS20079150,
SKNSH20030640, SPLEN20023850, SPLEN20057830, SPLEN20139360,
SPLEN20190430, TESTI20006830, TESTI20030200, TESTI20031410,
TESTI20035790, TESTI20062120, TESTI20065650, TESTI20081890,
TESTI20150920, TESTI20153310, TESTI20201760, TESTI20212970,
TESTI20227380, TESTI20251740, TESTI20256560, TESTI20260640,
TESTI20270130, TESTI20284260, TESTI20285230, THYMU20021090,
THYMU20049060, THYMU20066660, THYMU20081110, THYMU20090230,
THYMU20120240, UTERU10001060, UTERU20104310
[0104] The following 20 clones presumably belong to the category of
protein synthesis- and/or protein transport-related proteins.
TABLE-US-00011 BRAMY20038980, BRAMY20274510, CTONG20008190,
CTONG20033610, FCBBF20018680, FEBRA20090220, KIDNE20141700,
NT2NE20167660, NTONG20055200, PLACE60012620, PROST20036350,
PROST20062820, SKMUS20040440, SMINT20000070, SPLEN20180980,
TESTI20055680, TESTI20067440, TESTI20107240, THYMU20096580,
THYMU20121040
[0105] The following 10 clones presumably belong to the category of
cellular defense-related proteins. TABLE-US-00012 ASTRO20089600,
BRAMY20117670, FEBRA20087550, HLUNG20081390, MESAN20057240,
NTONG20031580, PROST20007600, SPLEN20023850, SPLEN20043680,
TESTI20261680
[0106] The following 19 clones presumably belong to the category of
development and/or differentiation-related proteins. TABLE-US-00013
BRACE20061620, BRACE20200770, BRAMY20013670, CTONG20017490,
CTONG20020950, HCHON10000150, MESAN20021470, OCBBF20165910,
PROST20155370, PUAEN20002470, TESTI20079220, TESTI20079980,
TESTI20166670, TESTI20184760, TESTI20252690, TRACH20040390,
UTERU20089620, UTERU20094830, UTERU20169020
[0107] The following 168 clones presumably belong to the category
of DNA- and/or RNA-binding proteins. TABLE-US-00014 ASTRO20038400,
BGGI120010750, BNGH420070370, BRACE20003310, BRACE20061620,
BRAMY20001510, BRAMY20040580, BRAMY20076100, BRAMY20111780,
BRAMY20274510, BRAWH20040680, BRAWH20050740, BRAWH20063010,
BRAWH20080580, BRAWH20095900, BRAWH20174330, BRSSN20066440,
CTONG20020950, CTONG20044230, CTONG20053990, CTONG20072930,
CTONG20074000, CTONG20165750, CTONG20186370, CTONG20186520,
DFNES20046840, DFNES20073320, FCBBF20035430, FCBBF20070950,
FCBBF30002270, FCBBF30003610, FCBBF30019140, FCBBF30021900,
FCBBF30048420, FCBBF30080730, FCBBF30093170, FCBBF30114850,
FCBBF30129010, FCBBF30136230, FCBBF30220050, FCBBF30228940,
FCBBF30236670, FCBBF30263080, FCBBF30285930, FCBBF50003530,
FEBRA20026820, FEBRA20027070, FEBRA20035240, FEBRA20046510,
FEBRA20057010, FEBRA20063720, FEBRA20087550, FEBRA20092760,
FEBRA20170240, FEBRA20177800, HCHON20002650, HEART20019310,
HEART20063100, HHDPC20081230, HLUNG20011460, HLUNG20014590,
HLUNG20028110, HLUNG20063700, HLUNG20068120, KIDNE20140870,
LIVER20006260, MESAN20016270, MESAN20056890, MESAN20057240,
NT2NE20038870, NT2NE20053950, NT2NE20060750, NT2NE20079670,
NT2NE20082600, NT2NE20087270, NT2RP70029780, NT2RP70046410,
NT2RP70057500, NT2RP70075300, NT2RP70090870, OCBBF20116250,
OCBBF20120950, OCBBF20121910, OCBBF20156450, OCBBF20157970,
OCBBF20166900, OCBBF20175360, OCBBF20177540, PEBLM10001470,
PEBLM20003260, PLACE60066970, PLACE60122970, PLACE60177880,
PROST20007170, PROST20024250, PROST20035170, PROST20051310,
PROST20058860, PROST20151370, PROST20155370, PUAEN20003120,
SMINT20011950, SMINT20030740, SMINT20039050, SMINT20044140,
SMINT20086720, SPLEN20042200, SPLEN20043680, SPLEN20055600,
SPLEN20059270, SPLEN20063250, SPLEN20139360, SPLEN20190430,
TESTI10001570, TESTI20006830, TESTI20030200, TESTI20031410,
TESTI20035790, TESTI20057430, TESTI20059810, TESTI20062120,
TESTI20067480, TESTI20068790, TESTI20075240, TESTI20079220,
TESTI20088840, TESTI20104090, TESTI20134970, TESTI20166670,
TESTI20171070, TESTI20173960, TESTI20184760, TESTI20197600,
TESTI20201760, TESTI20212970, TESTI20227380, TESTI20228740,
TESTI20246480, TESTI20254030, TESTI20254990, TESTI20266050,
TESTI20268240, TESTI20270130, TESTI20274960, TESTI20282530,
TESTI20284260, TESTI20285230, THYMU10004280, THYMU20019260,
THYMU20023560, THYMU20032820, THYMU20049060, THYMU20066660,
THYMU20071120, THYMU20077250, THYMU20081110, THYMU20090230,
TKIDN10001920, TRACH20108240, UTERU10001060, UTERU20026620,
UTERU20041630, UTERU20094830, UTERU20099510, UTERU20101150,
UTERU20169020, UTERU20177150, UTERU20188670
[0108] The following 93 clones presumably belong to the category of
ATP- and/or GTP-binding proteins. TABLE-US-00015 ASTRO20026320,
BNGH420035290, BRACE20050870, BRACE20079370, BRACE20200770,
BRAMY20055760, BRAMY20118490, BRAMY20244490, BRAMY20251210,
BRAWH20093040, BRAWH20190550, BRCAN10001050, BRCOC20003600,
CTONG20008190, CTONG20030280, CTONG20032930, CTONG20176040,
CTONG20184830, FCBBF20023490, FCBBF30019140, FCBBF30076310,
FCBBF30105860, FCBBF30175350, FCBBF30201630, FCBBF30236670,
FEBRA20005040, FEBRA20090160, FEBRA20173330, HCHON20000870,
HLUNG20011260, HLUNG20052300, KIDNE20081170, KIDNE20134890,
LIVER20030650, LIVER20055270, MESAN20065990, NT2NE20042550,
NTONG20043080, NTONG20055200, OCBBF20182060, PLACE60054870,
PLACE60064180, PLACE60095600, PLACE60140640, PROST20015210,
PROST20033240, PROST20036350, PROST20051310, PROST20052850,
PROST20062820, PROST20075280, PROST20120070, PUAEN20002470,
SKNSH20052400, SKNSH20057920, SMINT20008110, SPLEN20023850,
SPLEN20043680, SPLEN20049840, SPLEN20136730, SPLEN20180980,
SPLEN20193790, TESTI20055680, TESTI20058920, TESTI20060080,
TESTI20064650, TESTI20071130, TESTI20099350, TESTI20106820,
TESTI20112860, TESTI20134680, TESTI20136010, TESTI20143180,
TESTI20175370, TESTI20212970, TESTI20222460, TESTI20227380,
TESTI20244220, TESTI20244460, TESTI20264530, THYMU20013250,
THYMU20039320, THYMU20062610, THYMU20066660, THYMU20087270,
THYMU20096580, THYMU20100940, THYMU20176010, TRACH20043360,
TRACH20098510, TRACH20113020, UTERU20185220, UTERU20188670
[0109] Among the clones other than the ones shown above,
BNGH420036410, FCBBF30257370 are clones which were predicted to
highly possibly belong to the category of secretory protein and/or
membrane protein based on the result of domain search by Pfam.
SMINT20044730, TESTI20140970
[0110] The two clones shown above are clones which were predicted
to highly possibly belong to the category of glycoprotein-related
protein based on the result of domain search by Pfam.
TABLE-US-00016 BRACE20055560, CTONG20046690, DFNES20043710,
FCBBF30005500, MESAN20030350, MESAN20030370, PLACE60074820,
TESTI20058350, TESTI20106170, TRACH20131230, UTERU20000950
[0111] The 11 clones shown above are clones which were predicted to
highly possibly belong to the category of signal
transduction-related protein based on the result of domain search
by Pfam. TABLE-US-00017 ASTRO20010290, BRACE20099070,
CTONG20007660, DFNES20076340, DFNES20094820, FCBBF30125460,
FCBBF30142290, FCBBF30169280, FEBRA20031000, NT2NE20026510,
NT2RP70031340, PLACE50001390, SPLEN20135030, TESTI20046890,
TESTI20060350, TESTI20166290, TESTI20259110, THYMU20184550
[0112] The 18 clones shown above are clones which were predicted to
highly possibly belong to the category of transcription-related
protein based on the result of domain search by Pfam.
TABLE-US-00018 ADRGL20047770, ADRGL20079060, BRACE20014450,
BRACE20051600, BRAWH20185260, CTONG20033750, CTONG20070090,
CTONG20190290, FCBBF20020440, FCBBF30005360, FCBBF30173960,
FEBRA20031000, KIDNE20087880, LIVER20013890, MESAN20030350,
MESAN20030370, OCBBF20113110, PLACE60074820, PLACE60093380,
PROST20028970, PROST20102190, SALGL10001070, SPLEN20006950,
SPLEN20011350, SPLEN20050090, TESTI20060830, TESTI20066150,
TESTI20120900, TESTI20132310, TESTI20148380, TESTI20162980,
TESTI20166290, TESTI20205100, THYMU20112590, TRACH20029880
[0113] The 35 clones shown above are clones which were predicted to
highly possibly belong to the category of enzyme and/or
metabolism-related protein based on the result of domain search by
Pfam.
PLACE60054820, TESTI20197030
[0114] The two clones shown above are clones which were predicted
to highly possibly belong to the category of cell division and/or
cell proliferation-related protein based on the result of domain
search by Pfam.
ASTRO20006530, OCBBF20016390, TRACH20058000
[0115] The three clones shown above are clones which were predicted
to highly possibly belong to the category of cytoskeleton-related
protein based on the result of domain search by Pfam.
BRACE20065470, PLACE60054820
[0116] The two clones shown above are clones which were predicted
to highly possibly belong to the category of nuclear protein and/or
RNA synthesis-related protein based on the result of domain search
by Pfam. TABLE-US-00019 ASTRO20010290, BRACE20099070,
BRAWH20014590, CTONG20007660, DFNES20076340, DFNES20094820,
FCBBF30125460, FCBBF30142290, FCBBF30169280, FEBRA20031000,
MESAN20034440, NT2NE20026510, NT2RP70031340, PLACE50001390,
SPLEN20135030, TESTI20046890, TESTI20060350, TESTI20166290,
TESTI20259110, THYMU20104480, THYMU20184550
[0117] The 21 clones shown above are clones which were predicted to
highly possibly belong to the category of DNA- and/or RNA-binding
protein based on the result of domain search by Pfam.
KIDNE20133880, MESAN20030350, MESAN20030370, TESTI20059480
[0118] The four clones shown above are clones which were predicted
to highly possibly belong to the category of ATP- and/or
GTP-binding proteins based on the result of domain search by
Pfam.
[0119] The 205 clones shown below are clones which were
unassignable to any of the above-mentioned categories, but have
been predicted to have some functions based on homology search
using their full-length nucleotide sequences and motif search in
their estimated ORFs. Clone Name, Definition in the result of
homology search or Motif Name in the motif search, demarcated by a
double slash mark (//), are shown below. [0120]
ADRGL20022600//DIAPHANOUS PROTEIN HOMOLOG 1 (P140MDIA). [0121]
ADRGL20023920//ABC1 PROTEIN HOMOLOG PRECURSOR. [0122]
ASTRO20001910//Rattus norvegicus mRNA for annexin V-binding protein
(ABP-10), partial cds. [0123] ASTRO20009140//PUTATIVE
COMPETENCE-DAMAGE PROTEIN. [0124] ASTRO20046280//PSU1 PROTEIN.
[0125] ASTRO20058960//DNA damage inducible protein homolog--fission
yeast (Schizosaccharomyces pombe) [0126] BNGH420024870//C2
domain//C2 domain//C2 domain [0127] BRACE20007330//RING CANAL
PROTEIN (KELCH PROTEIN). [0128] BRACE20052430//Homo sapiens AMSH
mRNA, complete cds. [0129] BRACE20054600//Xenopus laevis mRNA for
Kielin, complete cds. [0130] BRACE20059810//TSC-22/dip/bun family
[0131] BRACE20063540//MEROZOITE SURFACE PROTEIN CMZ-8 (FRAGMENT).
[0132] BRACE20079200//Xenopus laevis mRNA for Kielin, complete cds.
[0133] BRAMY20016780//Proprotein convertase P-domain [0134]
BRAMY20023640//UBX domain [0135] BRAMY20045420//Domain found in
Dishevelled, Egl-10, and Pleckstrin [0136] BRAMY20056840//UBE-1c2
[0137] BRAMY20063750//Homo sapiens HRIHFB2007 mRNA, partial cds.
[0138] BRAMY20102900//Homo sapiens RU1 (RU1) mRNA, complete cds.
[0139] BRAMY20158550//CALMODULIN. [0140] BRAMY20223010//Mus
musculus leucine-rich glioma-inactivated 1 protein precursor,
(Lgi1) mRNA, complete cds. [0141] BRAMY20238630//TETRATRICOPEPTIDE
REPEAT PROTEIN 4. [0142] BRAMY20245760//Araneus diadematus
fibroin-4 mRNA, partial cds. [0143] BRAWH20047790//HMG (high
mobility group) box [0144] BRSSN20005610//Mus musculus semaphorin
cytoplasmic domain-associated protein 3A (Semcap3) mRNA, complete
cds. [0145] BRSSN20005660//Bacterial type II secretion system
protein [0146] BRSSN20093890//Homo sapiens mRNA for Kelch motif
containing protein, complete cds. [0147]
CTONG20041150//Streptomyces ansochromogenes strain 7100 SanE (sanE)
gene, complete cds. [0148] CTONG20066110//Homo sapiens DEME-6 mRNA,
partial cds. [0149] CTONG20069420//Ribosomal protein S14p/S29e
[0150] CTONG20071040//BETA CRYSTALLIN B2 (BP). [0151]
CTONG20074170//DENN (AEX-3) domain [0152] CTONG20083430//Nuclear
transition protein 2 [0153] CTONG20170940//MYOTROPHIN (V-1 PROTEIN)
(GRANULE CELL DIFFERENTIATION PROTEIN). [0154]
CTONG20174290//TRICHOHYALIN. [0155] CTONG20174580//Homo sapiens
mRNA for vascular Rab-GAP/TBC-containing protein complete cds.
[0156] CTONG20180690//Collagen triple helix repeat (20 copies)
[0157] CTONG20186550//cca3 protein--rat [0158] CTONG20188080//TPR
Domain [0159] FCBBF10004760//Homo sapiens GAP-like protein (N61)
mRNA, complete cds. [0160] FCBBF20033360//RING CANAL PROTEIN (KELCH
PROTEIN). [0161] FCBBF20041380//SAM domain (Sterile alpha motif)
[0162] FCBBF20043730//UBA domain [0163] FCBBF20056580//Mus musculus
NSD1 protein mRNA, complete cds. [0164] FCBBF20059660//TPR Domain
[0165] FCBBF30019180//SERINE/THREONINE PROTEIN PHOSPHATASE 2A, 65
KDA REGULATORY SUBUNIT A, ALPHA ISOFORM (PP2A, SUBUNIT A,
PR65-ALPHA ISOFORM) (PP2A, SUBUNIT A, R1-ALPHA ISOFORM). [0166]
FCBBF30026580//Homo sapiens retinoblastoma-associated protein
RAP140 mRNA, complete cds. [0167] FCBBF30035570//C2 domain [0168]
FCBBF30079770//D-isomer specific 2-hydroxyacid dehydrogenases
[0169] FCBBF30100120//Mus musculus semaphorin cytoplasmic
domain-associated protein 3A (Semcap3) mRNA, complete cds. [0170]
FCBBF30100410//Mus musculus testis-specific Y-encoded-like protein
(Tspyl1) mRNA, complete cds. [0171] FCBBF30118890//Drosophila
melanogaster La related protein (larp) mRNA, partial cds. [0172]
FCBBF30138000//trg protein--rat [0173] FCBBF30157270//Rattus
norvegicus PAPIN mRNA, complete cds. [0174] FCBBF30161780//gag gene
protein p24 (core nucleocapsid protein)//Zinc knuckle [0175]
FCBBF30198670//dof protein--fruit fly (Drosophila melanogaster)
[0176] FCBBF30222910//Mus musculus Rap2 interacting protein 8
(RPIP8) mRNA, complete cds. [0177] FCBBF30255680//Rattus norvegicus
brain specific cortactin-binding protein CBP90 mRNA, partial cds.
[0178] FCBBF30260210//Drosophila melanogaster KISMET-L long isoform
(kis) mRNA, complete cds. [0179] FCBBF30282020//cca3 protein--rat
[0180] FCBBF40000610//late gestation lung 2 protein [Rattus
norvegicus]. [0181] FEBRA20029620//Leucine Rich Repeat//Leucine
Rich Repeat//Leucine Rich Repeat [0182] FEBRA20031150//Homo sapiens
HSKM-B (HSKM-B) mRNA, complete cds. [0183]
FEBRA20038330//Corticotropin-releasing factor family [0184]
FEBRA20038970//Homo sapiens mRNA for stabilin-1 (stab1 gene).
[0185] FEBRA20088610//CELLULAR RETINALDEHYDE-BINDING PROTEIN
(CRALBP). [0186] FEBRA20150420//HYPOTHETICAL 131.5 KDA PROTEIN
C02F12.7 IN CHROMOSOME X. [0187] FEBRA20175330//D-isomer specific
2-hydroxyacid dehydrogenases [0188] HEART10001420//Mus musculus
skm-BOP1 (Bop) mRNA, complete cds. [0189] HLUNG20024050//Rubredoxin
[0190] HLUNG20030420//Mus musculus mRNA for MAIL, complete cds.
[0191] HLUNG20030490//Ambystoma tigrinum RPE65 protein mRNA,
complete cds. [0192] HLUNG20033060//Homo sapiens GAP-like protein
(N61) mRNA, complete cds. [0193] HLUNG20041590//ubiquitous
tetratricopeptide containing protein RoXaN [Homo sapiens]. [0194]
HLUNG20045340//MOB2 PROTEIN (MPS1 BINDER 2). [0195]
HLUNG20051330//FHIPEP family [0196] HLUNG20070410//Dihydropyridine
sensitive L-type calcium channel (Beta subunit) [0197]
HLUNG20072100//Gallus gallus Dach2 protein (Dach2) mRNA, complete
cds. [0198] HLUNG20083480//Chicken mRNA for TSC-22 variant,
complete cds, clone SLFEST52. [0199] KIDNE20027980//SAM domain
(Sterile alpha motif) [0200] KIDNE20084730//Homo sapiens FH1/FH2
domain-containing protein FHOS (FHOS) mRNA, complete cds. [0201]
KIDNE20149780//NG28 [Mus musculus] [0202] KIDNE20154330//Rattus
norvegicus mRNA for multi PDZ domain protein. [0203]
KIDNE20170400//Leucine Rich Repeat//Leucine Rich Repeat//Leucine
Rich Repeat//Protein kinase C terminal domain//Rubredoxin [0204]
KIDNE20189890//Homo sapiens mRNA for KARP-1-binding protein 2
(KAB2), complete cds. [0205] LIVER20010760//Homo sapiens C-type
lectin-like receptor-1 mRNA, complete cds. [0206]
LIVER20040740//RETINAL-BINDING PROTEIN (RALBP). [0207]
MESAN20009090//Homo sapiens CEGP1 protein (CEGP1), mRNA [0208]
MESAN20026870//PAN domain//TBC domain [0209] MESAN20090190//CEGP1
protein [Homo sapiens]. [0210] NT2NE20059680//Homo sapiens integrin
cytoplasmic domain associated protein (Icap-1a) mRNA, complete cds.
[0211] NT2NE20077270//Adenovirus EB1 55K protein/large t-antigen
[0212] NT2NE20087850//ANTER-SPECIFIC PROLINE-RICH PROTEIN APG
(PROTEIN CEX) (FRAGMENT). [0213] NT2NE20095230//Homo sapiens HSKM-B
(HSKM-B) mRNA, complete cds. [0214] NT2NE20108420//KES1 PROTEIN.
[0215] NT2NE20173970//Rattus norvegicus beta-catenin binding
protein mRNA, complete cds. [0216] NT2NE20177210//Leishmania major
partial ppg1 gene for proteophosphoglycan. [0217]
NT2RP70012830//CALPHOTIN. [0218] NT2RP70035110//Caenorhabditis
elegans UNC-89 (unc-89) gene, complete cds. [0219]
NTONG20002230//Mus musculus RW1 protein mRNA, complete cds. [0220]
NTONG20005310//Ribosomal protein S9/S16 [0221]
NTONG20029850//CALCYPHOSINE (R2D5 ANTIGEN). [0222]
NTONG20035150//RING CANAL PROTEIN (KELCH PROTEIN). [0223]
NTONG20058220//Homo sapiens phosphoprotein pp75 mRNA, partial cds.
[0224] OCBBF20005220//Rattus norvegicus Fos-related antigen mRNA,
complete cds. [0225] OCBBF20011860//Mus musculus epithelial protein
lost in neoplasm-a (Eplin) mRNA, complete cds. [0226]
OCBBF20016810//enhancer of polycomb [Mus musculus] [0227]
OCBBF20147070//DNA polymerase (viral) C-terminal domain [0228]
OCBBF20160380//liver stage antigen LSA-1--Plasmodium falciparum
[0229] OCBBF20177910//Corticotropin-releasing factor family [0230]
PEBLM20005020//Virion host shutoff protein [0231]
PLACE60055460//Homo sapiens leucine-zipper protein FKSG13 (FKSG13)
mRNA, complete cds. [0232] PLACE60068710//SUPPRESSOR PROTEIN SRP40.
[0233] PLACE60080360//mucin [Homo sapiens] [0234]
PLACE60082850//Pathogenesis-related protein Bet v I family [0235]
PLACE60098350//Human hepatocellular carcinoma associated protein
(JCL-1) mRNA, complete cds. [0236] PLACE60105680//Homo sapiens mRNA
for TU12B1-TY, complete cds. [0237] PLACE60119700//Homo sapiens
mRNA for ABP32, complete cds. [0238] PLACE60120280//SER/THR-RICH
PROTEIN T10 IN DGCR REGION. [0239] PLACE60132200//TRICHOHYALIN.
[0240] PLACE60181870//Pentaxin family [0241]
PROST20084470//Plasmodium berghei strain NYU2 merozoite surface
protein-1 mRNA, partial cds. [0242] PROST20087240//gag gene protein
p24 (core nucleocapsid protein) [0243] PROST20122490//Gallus gallus
syndesmos mRNA, complete cds. [0244] PROST20130320//S-100/ICaBP
type calcium binding domain [0245] PROST20152870//Homo sapiens APC2
gene, exon 14. [0246] PUAEN10001640//Mus musculus cerebellar
postnatal development protein-1 (Cpd1) mRNA, partial cds. [0247]
PUAEN20000800//Bleomycin resistance protein [0248]
SMINT20012220//Collagen triple helix repeat (20 copies) [0249]
SMINT20035510//Drosophila melanogaster La related protein (larp)
mRNA, partial cds. [0250] SMINT20036440//Drosophila melanogaster
epsin-like protein mRNA, complete cds. [0251] SMINT20038660//Homo
sapiens HNOEL-iso (HNOEL-iso) mRNA, complete cds. [0252]
SMINT20043390//Ras association (RalGDS/AF-6) domain [0253]
SMINT20048720//Cytochrome P450//Cytochrome P450 [0254]
SMINT20052130//Rattus norvegicus mRNA for gankyrin homologue,
complete cds. [0255] SMINT20054050//ABC1 PROTEIN HOMOLOG PRECURSOR.
[0256] SPLEN20024770//Rattus norvegicus (rsec6) mRNA, complete cds.
[0257] SPLEN20040780//CORNIFIN B (SMALL PROLINE-RICH PROTEIN 1B)
(SPR1B) (SPR1 B). [0258] SPLEN20041810//BC-2 protein [Homo sapiens]
[0259] SPLEN20100040//258.1 KDA PROTEIN C210RF5 (KIAA0933). [0260]
SPLEN20104150//Ribosomal protein L36 [0261] SPLEN20116720//Homo
sapiens misato mRNA, partial cds. [0262] SPLEN20176130//Homo
sapiens mRNA for ALEX1, complete cds. [0263]
SPLEN20181570//TRICHOHYALIN. [0264] TESTI20004310//TRICHOHYALIN.
[0265] TESTI20016970//TPR Domain [0266]
TESTI20030440//TRICHOHYALIN. [0267] TESTI20043180//mouse mRNA for
megakaryocyte potentiating factor, complete cds. [0268]
TESTI20043910//IQ calmodulin-binding motif//IQ calmodulin-binding
motif//IQ calmodulin-binding motif//IQ calmodulin-binding motif//IQ
calmodulin-binding motif [0269] TESTI20044900//Strongylocentrotus
purpuratus radial spokehead mRNA, complete cds. [0270]
TESTI20046110//Extracellular link domain [0271] TESTI20047930//Homo
sapiens NY-REN-2 antigen mRNA, complete cds. [0272]
TESTI20049410//Proprotein convertase P-domain [0273]
TESTI20053950//IQ calmodulin-binding motif [0274]
TESTI20054700//Streptococcus pneumoniae strain g375 surface protein
PspC (pspC) gene, pspC-8.1 allele, complete cds. [0275]
TESTI20055880//Serum amyloid A protein [0276] TESTI20056030//Homo
sapiens 88-kDa Golgi protein (GM88) mRNA, complete cds. [0277]
TESTI20061090//Keratin, high sulfur B2 protein [0278]
TESTI20064370//TPR Domain//TPR Domain//TPR Domain//TPR
Domain//Synaptobrevin [0279] TESTI20084250//OXYSTEROL-BINDING
PROTEIN. [0280] TESTI20092170//ENV polyprotein (coat polyprotein)
[0281] TESTI20116050//UBX domain [0282] TESTI20120500//Kelch
motif//Kelch motif [0283] TESTI20126280//Mus musculus STAP mRNA for
sperm tail associated protein, complete cds. [0284]
TESTI20144390//TESTIS-SPECIFIC PROTEIN PBS13. [0285]
TESTI20165990//Ribosomal protein L36 [0286]
TESTI20169500//HYPOTHETICAL 51.9 KDA PROTEIN C27F1.04C IN
CHROMOSOME I. [0287] TESTI20170280//Flagellar L-ring protein [0288]
TESTI20176450//thioredoxin interacting factor [Mus musculus].
[0289] TESTI20179230//Dihydropyridine sensitive L-type calcium
channel (Beta subunit) [0290] TESTI20180600//Homo sapiens
HOM-TES-85 tumor antigen mRNA, complete cds. [0291]
TESTI20209050//HYPOTHETICAL 113.1 KDA PROTEIN IN PRE5-FET4
INTERGENIC REGION. [0292] TESTI20210570//RETINAL-BINDING PROTEIN
(RALBP). [0293] TESTI20215310//Homo sapiens calcyclin binding
protein mRNA, complete cds. [0294] TESTI20247440//Human BLu protein
testis isoform (BLu) mRNA, complete cds. [0295] TESTI20249360//Homo
sapiens DEME-6 mRNA, partial cds. [0296]
TESTI20250220//TRICHOHYALIN. [0297] TESTI20251440//Rattus
norvegicus (rsec6) mRNA, complete cds. [0298] TESTI20255460//Mus
musculus mRNA for MIWI (piwi), complete cds. [0299]
THYMU20009500//TPR Domain [0300] THYMU20010180//MOB1 PROTEIN (MPS1
BINDER 1). [0301] THYMU20013810//Human SEC7 homolog Tic (TIC) mRNA,
complete cds. [0302] THYMU20018250//TPR Domain [0303]
THYMU20026950//Mus musculus ROSA 26 transcription AS ROSA26AS mRNA,
complete cds. [0304] THYMU20028410//Mus musculus Pax transcription
activation domain interacting protein PTIP mRNA, complete cds.
[0305] THYMU20030460//Homo sapiens tumor endothelial marker 7
precursor (TEM7) mRNA, complete cds. [0306] THYMU20031330//Homo
sapiens putative nucleotide binding protein mRNA, complete cds.
[0307] THYMU20052460//PHORBOLIN I (FRAGMENTS). [0308]
THYMU20055450//Zona pellucida-like domain [0309]
THYMU20083830//Homo sapiens angiostatin binding protein 1 mRNA,
complete cds. [0310] THYMU20139160//Uncharacterized protein family
UPF0031 [0311] THYMU20151610//Homo sapiens antigen NY-CO-1
(NY-CO-1) mRNA, complete cds. [0312] TRACH20093400//TRICHOHYALIN.
[0313] TRACH20104510//Uncharacterized protein family UPF0005 [0314]
TRACH20122980//HYPOTHETICAL PROTEIN MJ0798. [0315]
TRACH20139280//PX domain [0316] TRACH20164810//D-isomer specific
2-hydroxyacid dehydrogenases [0317] TRACH20165540//Human alpha-1
type I collagen gene surrounding osteogenesis imperfecta OI type II
deletion. [0318] UTERU20051790//guanylate kinase-interacting
protein 1 Maguin-1, membrane-associated--rat [0319]
UTERU20083020//Domain of unknown function DUF71 [0320]
UTERU20121140//Rhodanese-like domain [0321] UTERU20128560//26.4 KDA
PROTEIN IN RUVC-ASPS INTERGENIC REGION. [0322]
UTERU20132620//AXONEME-ASSOCIATED PROTEIN MST101(2). [0323]
UTERU20134830//pellino (Drosophila) homolog 2 [Homo sapiens] [0324]
UTERU20181270//Zinc knuckle
[0325] Further, the reason is that a polypeptide does not always
belong solely to a single category of the above-described
functional categories, and therefore, a polypeptide may belong to
any of the predicted functional categories. Besides, additional
functions can be found for the clones classified into these
functional categories by further analyses.
[0326] Since the polypeptide encoded by clones of the invention
contains full-length amino acid sequence, it is possible to analyze
its biological activity, and its effect on cellular conditions such
as cell proliferation and differentiation by expressing the
polypeptide as a recombinant polypeptide using an appropriate
expression system, injecting the recombinant into the cell, or
raising a specific antibody against the polypeptide.
[0327] The biological activities of respective polypeptides can be
analyzed by the methods as shown below. Secretory protein,
transmembrane protein: [0328] `Ion Channels` (Ed., R. H. Ashley,
1995) of "The Practical Approach Series" (IRL PRESS), [0329]
"Growth Factors" (Eds., I. McKay, I. Leigh, 1993), [0330]
"Extracellular Matrix" (Eds., M. A. Haralson, J. R. Hassell, 1995);
Glycoprotein-Related Protein: [0331] "Glycobiology" (Eds., M.
Fukuda, A. Kobata, 1993) of "The Practical Approach Series" (IRL
PRESS), [0332] "Glycoprotein Analysis in Biomedicine" (Ed.,
Elizabeth F. Hounsell, 1993) of "Method in Molecular Biology"
(Humana Press) series; Signal Transduction-Related Protein: [0333]
"Signal Transduction" (Ed., G. Milligan, 1992) of "The Practical
Approach Series" (IRL PRESS), [0334] "Protein Phosphorylation"
(Ed., D. G. Hardie, 1993), or [0335] "Signal Transduction
Protocols" (Eds., David A. Kendall, Stephen J. Hill, 1995) of
"Method in Molecular Biology" (Humana Press) series;
Transcription-Related Protein: [0336] "Gene Transcription" (Eds.,
B. D. Hames, S. J. Higgins, 1993) of "The Practical Approach
Series" (IRL PRESS), [0337] "Transcription Factors" (Ed., D. S.
Latchman, 1993); Enzyme and/or Metabolism-Related Protein: [0338]
"Enzyme Assays" (Eds., ROBERT EISENTHAL and MICHAEL J. DANSON,
1992) of "The Practical Approach Series" (IRL PRESS); Cell Division
and/or Cell Proliferation-Related Protein: [0339] "Cell Growth,
Differentiation and Senescence" (Ed., GEORGE STUDZINSKI, 2000) of
"The Practical Approach Series" (IRL PRESS); Cytoskeleton-Related
Protein: [0340] "Cytoskeleton: Signalling and Cell Regulation"
(Eds., KERMIT L. CARRAWAY and CAROLIE A. CAROTHERS CARRAWAY, 2000)
of "The Practical Approach Series" (IRL PRESS), [0341]
"Cytoskeleton Methods and Protocols" (Ed., Gavin, Ray H., 2000) of
"Method in Molecular Biology" (Humana Press) series; Nuclear
Protein and/or RNA Synthesis-Related Protein: [0342] "Nuclear
Receptors" (Ed., DIDIER PICARD, 1999) of "The Practical Approach
Series" (IRL PRESS), [0343] "RNA Processing" (Eds., STEPHEN J.
HIGGINS and B. DAVID HAMES, 1994); Protein Synthesis and/or
Transport-Related Protein: [0344] "Membrane Transport" (Ed.,
STEPHEN A. BALDWIN, 2000) of "The Practical Approach Series" (IRL
PRESS), [0345] "Protein Synthesis Methods and Protocols" (Eds.,
Martin, Robin, 1998) of "Method in Molecular Biology" (Humana
Press) series; Cellular Defense-Related Protein: [0346] "DNA Repair
Protocols" (Henderson, Daryl S., 1999) of "Method in Molecular
Biology" (Humana Press) series, [0347] "Chaperonin Protocols"
(Eds., Schneider, Christine, 2000); Development and/or
Differentiation-Related Protein: [0348] "Developmental Biology
Protocols" (Eds., ROBERT EISENTHAL and MICHAEL J. DANSON, 1992) of
"Method in Molecular Biology" (Humana Press) series; DNA- and/or
RNA-Binding Protein: [0349] "DNA-Protein Interactions Principles
and Protocols" (Eds., Kneale, G. Geoff, 1994) of "Method in
Molecular Biology" (Humana Press) series, [0350] "RNA-Protein
Interaction Protocols" (Eds., Haynes, Susan R., 1999); ATP- and/or
GTP-Binding Protein: [0351] "Signal Transduction Protocols" (Eds.,
David A. Kendall, Stephen J. Hill, 1995) of "Method in Molecular
Biology" (Humana Press) series.
[0352] In the categorization, the clone predicted to belong to the
category of secretory and/or membrane protein means a clone having
hit data with some annotation, such as growth factor, cytokine,
hormone, signal, transmembrane, membrane, extracellular matrix,
receptor, G-protein coupled receptor, ionic channel, voltage-gated
channel, calcium channel, cell adhesion, collagen, connective
tissue, etc., suggesting that it was a secretory or membrane
protein, or a clone in which the presence of nucleotide sequence
encoding a signal sequence or transmembrane region was suggested by
the results of PSORT and SOSUI analyses for deduced ORF.
[0353] The clone predicted to belong to the category of
glycoprotein-related protein means a clone having hit data with
some annotation, such as glycoprotein, suggesting that the clone
encodes a glycoprotein-related protein.
[0354] The clone predicted to belong to the category of signal
transduction-related protein means a clone having hit data with
some annotation, such as serine/threonine-protein kinase,
tyrosine-protein kinase, SH3 domain, SH2 domain, etc., suggesting
that the clone encodes a signal transduction-related protein.
[0355] The clone predicted to belong to the category of
transcription-related protein means a clone having hit data with
some annotation, such as transcription regulation, zinc finger,
homeobox, etc., suggesting that the clone encodes a
transcription-related protein.
[0356] The clone predicted to belong to the category of
disease-related protein means a clone having hit data with some
annotation, such as disease mutation, syndrome, etc., suggesting
that the clone encodes a disease-related protein, or a clone whose
full-length nucleotide sequence has hit data for Swiss-Prot,
GenBank, UniGene, or nr, where the hit data corresponds to genes or
polypeptides which have been deposited in the Online Mendelian
Inheritance in Man (OMIM) (http://www.ncbi.nlm.nih.gov/Omim/),
which is the human gene and disease database described later.
[0357] The clone predicted to belong to the category of enzyme
and/or metabolism-related protein means a clone having hit data
with some annotation, such as metabolism, oxidoreductase, E. C. No.
(Enzyme commission number), etc., suggesting that the clone encodes
an enzyme and/or metabolism-related protein.
[0358] The clone predicted to belong to the category of cell
division and/or cell proliferation-related protein means a clone
having hit data with some annotation, such as cell division, cell
cycle, mitosis, chromosomal protein, cell growth, apoptosis, etc.,
suggesting that the clone encodes a cell division and/or cell
proliferation-related protein.
[0359] The clone predicted to belong to the category of
cytoskeleton-related protein means a clone having hit data with
some annotation, such as structural protein, cytoskeleton,
actin-binding, microtubles, etc., suggesting that the clone encodes
a cytoskeleton-related protein.
[0360] The clone predicted to belong to the category of nuclear
protein and/or RNA synthesis-related protein means a clone having
hit data with some annotation, such as nuclear protein, RNA
splicing, RNA processing, RNA helicase, polyadenylation, etc.,
suggesting that the clone encodes a nuclear protein and/or RNA
synthesis-related protein.
[0361] The clone predicted to belong to the category of protein
synthesis and/or transport-related protein means a clone having hit
data with some annotation, such as translation regulation, protein
biosynthesis, amino-acid biosynthesis, ribosomal protein, protein
transport, signal recognition particle, etc., suggesting that the
clone encodes a protein synthesis and/or transport-related
protein.
[0362] The clone predicted to belong to the category of cellular
defense-related protein means a clone having hit data with some
annotation, such as heat shock, DNA repair, DNA damage, etc.,
suggesting that the clone encodes a cellular defense-related
protein.
[0363] The clone predicted to belong to the category of development
and/or differentiation-related proteins means a clone having hit
data with some annotation, such as developmental protein, etc.,
suggesting that the clone encodes a development and/or
differentiation-related protein.
[0364] The clone predicted to belong to the category of DNA- and/or
RNA-binding protein means a clone having hit data with some
annotation, such as DNA-binding, RNA-binding, etc.
[0365] The clone predicted to belong to the category of ATP-and/or
GTP-binding protein means a clone having hit data with some
annotation, such as ATP-binding, GTP-binding, etc.
[0366] As to a protein involved in a disease, it is possible to
perform a functional analysis as described above, but also possible
to analyze correlation between the expression or the activity of
the protein and a certain disease by using a specific antibody that
is obtained by using expressed protein. Alternatively, it is
possible to utilize the database OMIM, which is a database of human
genes and diseases, to analyze the protein. Further, new
information is constantly being deposited in the OMIM database.
Therefore, it is possible for one skilled in the art to find a new
relationship between a particular disease and a gene of the present
invention in the most up-to-date database. The proteins involved in
diseases are useful for developing a diagnostic marker or medicines
for regulation of their expression and activity, or as a target of
gene therapy.
[0367] Also, as for a secretory protein, membrane protein, signal
transduction-related protein, glycoprotein-related protein, or
transcription-related protein, etc., search of the OMIM with the
following keywords resulted in the finding that the proteins are
involved in many diseases (the result of the OMIM search for
secrete and membrane proteins is shown below). Also, association
between proteins related to signal transduction or transcription
and diseases is reported in "Transcription Factor Research-1999"
(Fujii, Tamura, Morohashi, Kageyama, and Satake edit, (1999)
Jikken-Igaku Zoukan, Vol. 17, No. 3), and "Gene Medicine", (1999)
Vol. 3, No. 2). When cancer is used as an example, as described in
"Biology of Cancer" (S. Matsubara, 1992) of Life Science series
(Shokabo), many proteins are involved in cancers, which include
enzyme and/or metabolism-related proteins, cytoskeleton-related
proteins, cell division and/or cell proliferation-related proteins
as well as secretory proteins, membrane proteins, signal
transduction-related proteins, glycoprotein-related proteins,
transcription-related proteins. As clearly seen by the above
example, it is evident that not only disease-related proteins but
also secretory proteins, membrane proteins, signal
transduction-related proteins, glycoprotein-related proteins,
transcription-related proteins, etc. are often involved in
diseases, and thus they can be useful targets in the field of
medical industry.
[0368] The result of the OMIM search for secretory and membrane
proteins is shown below, in which the keywords, [0369] (1)
secretion protein, [0370] (2) membrane protein, [0371] (3) channel,
and [0372] (4) extracellular matrix were used.
[0373] Shown in the search result are only the accession numbers in
the OMIM. Using the number, data showing the relationship between a
disease and a gene or protein can be seen. The OMIM data has been
renewed everyday.
1) Secretion Protein
[0374] 354 entries found, searching for "secretion protein"
TABLE-US-00020 *604667, *104760, *176860, *151675, *139320,
*107400, *604029, *118910, #200100, *176880, *603850, *147572,
*604028, *179513, *125950, *139250, *246700, *600946, *600560,
*602926, 185860, *605083, *603215, *602421, *157147, *179512,
*600174, *109270, *604710, *138120, *179510, *600998, *179509,
*170280, *179511, *600626, *603831, *601489, *154545, *179490,
*603826, *122559, *603216, *102720, *147290, *164160, *603062,
*112262, *602672, *605435, *605322, *131230, *601652, *603166,
*601746, *601591, *179508, #160900, *104311, *600759, *147545,
*167805, #104300, *167770, #219700, *168470, *601684, *602049,
*601146, *605227, *602434, *602534, *114840, *603489, *604323,
*107470, *600753, *600768, *118825, *600564, *604252, *173120,
*134370, *192340, *308230, *600322, *605359, *600046, *300090,
106160, *600041, #262500, *605563, *150390, *158106, *182590,
#103580, *104610, #173900, *134797, *143890, #145980, *306900,
*308700, *176300, *227500, *137350, #154700, *138079, *600760,
*107730, *142410, *147670, *124092, *590050, *152760, *600509,
*605646, *201910, *227600, *152790, *300200, *300300, 300800,
*138160, *107741, *120150, *601199, *120180, *120160, *176730,
*133170, *122560, *107300, *137241, *120140, *101000, *193400,
*217000, *272800, *600937, #201710, *600377, #174800, *106100,
#274600, *173350, #177170, *147620, *214500, *131244, *202110,
*120120, *601007, *191160, *147470, *603372, *600733, *252800,
*190160, *138040, *158070, *162151, #125700, #130070, *113811,
*603355, *171060, *136435, #184700, *603732, *190180, *164008,
*186590, *120220, *604312, *152200, *138130, *605085, *605353,
*600840, #166210, *188545, *207750, *173360, *601933, #194050,
*153450, *138850, *253200, *307030, *157145, *600514, *600262,
*264080, *147380, *600281, #204000, #227810, *232200, *188826,
*232800, *161561, #166200, *188400, *153620, *182099, *218040,
#265800, *172400, #177200, *176805, #211600, #214700, #176410,
*152780, *600633, *601771, *301500, *605402, *601922, *307800,
*147892, *147720, *312060, #520000, *147660, *106150, *602358,
*107270, *601769, *147440, *604558, *131530, *600270, *601610,
*603692, *603401, *600423, *601604, *603345, #125853, *602843,
*142640, *603044, *605740, *134830, *602779, *130660, *139191,
*137035, *600761, *601340, *600823, *107740, *130160, *600877,
*605110, *600945, *130080, *600957, #130050, *605580, *118444,
*601124, *124020, 122470, *120700, *603201, *137216, *601185,
*138945, *218030, *600839, #240600, #262400, #162300, *162330,
*188450, #265850, *263200, *162641, *300159, *601038, #191390,
*201810, *601398, *602384, *131240, *602423, *139392, *142703,
*602663, *232700, *602682, #602722, *602730, *600734, *188540,
*182452, *601538, *603061, *146880, *603140, *603160, *142704,
#252650, *182280, *125255, *603252, #131750, *182139, *182100,
#259420, #261100, *603493, *601745, *182098, *603795, *123812,
*600264, *147940, *180246, *180245, *118888, #604284, *168450,
*118455, *604398, *604433, *601919, *118445, *600031, *604961,
*605032, *605033, *171050, #171300, *131243, *109160, *605254,
274900, #171400, *600042, *151670, *184600, *605470, *605546,
*176760, *602008, *102200, *605720, *600732, *605901
2) Membrane Protein
[0375] 1489 entries found, searching for "membrane protein"
TABLE-US-00021 *130500, *605704, *305360, *153330, *173610,
*109270, *170995, *170993, *104776, *602333, *309060, *605703,
*120920, *605943, *602690, *159430, *600897, *133090, *601178,
*602413, *602003, *604405, *605940, *603237, *109280, *600378,
*602173, *107776, *602334, *602335, *125305, *601134, *309845,
*605731, *154045, *603241, *603718, *600594, *603214, *185881,
*603657, *600182, *603177, *605331, *601476, *605456, *601114,
*605190, *600723, *603904, *136950, *300222, *602879, *185880,
*605348, *300096, *602257, *177070, *310200, *603062, *603344,
*600039, *602977, *300100, *128240, *600959, *600322, *227400,
*186945, *600946, *602534, *602048, *182900, *601097, *600267,
*602625, *136430, *602421, *601047, *107450, *143450, *603141,
*184756, *164730, *159440, *154050, *600579, *312080, *604202,
*603700, *600447, *256540, *604691, *158343, *600403, *602414,
*137290, *176640, *176981, *600179, *600754, *604456, *604693,
*605875, *604605, *188860, *300172, *602910, *604323, *219800,
*601848, *603179, *600279, *602251, #222700, *603831, *605072,
*605377, *601028, *604155, *108733, *104225, *601896, *601510,
*173335, *107770, *601767, *600046, *603850, *600040, *603784,
*603234, 188560, *605863, *121015, *605862, *605861, *186946,
*604252, *603215, *142461, *604597, *603143, *605264, *603735,
*176860, *605536, *176801, *180721, *603355, *104760, *131560,
*310300, *602631, *304700, #309400, *603142, *143890, *605431,
*600753, *115501, *176790, *600266, *601691, *168468, *601239,
*602216, #104300, *605613, *601595, *605550, *125950, *605475,
*602217, *602261, *603534, *602262, *604631, *190315, *601313,
*604306, *104311, *604672, *605000, *602461, *605548, *602296,
*604376, *121014, *121011, *600691, *604262, *139310, *304040,
*605445, *179514, *179512, *151460, #160900, *120130, *128239,
*601158, *601403, *176943, *601014, 300800, *300294, *601757,
*185470, *273800, *605034, *602887, #185000, *604871, *603593,
*603583, *605454, *104775, *605872, *141180, *602713, *603531,
*139150, *601531, *601832, *605452, *134651, *604156, *120620,
*605883, *604142, *166945, *605324, *600816, *604699, *300112,
*605182, *600164, *182180, *605071, *300023, *605057, *308240,
*300249, *176947, *176894, *605081, *605035, *602044, *182860,
*107271, *305100, *153390, *113730, *602689, *180069, *603518,
*300017, *191275, *177061, *601693, *601789, *604241, *600934,
*138160, *604424, *603868, *600174, *600718, *600523, *604141,
*601009, *605251, *600481, *600874, *155550, *605227, *601017,
*162230, 601138, *604157, *601212, *600763, *604110, *604158,
*601107, *601326, 600621, *600587, 601137, *600917, *600855,
*605058, *194355, *605194, *603291, *102720, *136425, *170715,
*603216, *605547, *135630, *602926, *600168, *605002, *602474,
*600157, *603025, *603893, *231200, *120090, *601966, *131230,
*604722, *604721, *604515, *246700, *602101, *605628, *303630,
*605787, *602857, *602285, *605708, *602488, *605025, *603817,
*300051, *603293, *176878, *603646, 605707, 185860, *112205,
*300187, *602654, *120070, *603648, *604850, *602655, *602514,
*300118, *182309, *179590, *602701, *600759, *204200, *604170,
*175100, #103580, *147670, *306400, *143100, *182870, *257220,
*180380, #116920, *301000, *193300, *157147, *131550, *139200,
*139130, *190195, *605406, *155760, *155960, *605734, *155970,
*605385, *111700, *155975, *150370, 605709, *151430, *605438,
*151510, *116952, *157655, *158105, *605777, *176877, *153619,
*120131, *185430, *109190, *120190, *109170, *605093, *605250,
*153432, *107777, *186590, *160993, *605699, *605698, *605813,
*605697, *605616, *605300, *162060, *605219, *163970, *135620,
*165040, *605478, *604964, *103195, *604932, *604923, *605906,
*605496, *605914, *166490, 138277, *604915, *114070, *605213,
*605933, *180297, *101000, *191163, *191164, *605101, *603167,
*600772, *603164, *600708, *604001, *191328, *313440, *602672,
*604009, *604299, *192974, *604256, *603048, *600515, *604221,
*602632, *604196, *601179, 603290, *604661, *601023, *601110,
*304800, *203200, *300212, *602933, *603352, *208900, *604418,
*604838, *600551, #212140, *604837, *602049, *600552, *600553,
*300213, *602574, *600583, *600932, *603452, *604775, *516020,
*604617, *604464, *603498, *300145, *601523, *602694, *600632,
*604762, *604492, *400015, *604504, *601717, *601728, *300242,
*602426, *604194, *603821, *604730, *600695, *603823, *603869,
*300241, *600707, *603822, *602370, *602202, *604193, *601181,
*604089, *602507, *604195, *602306, *300284, *601805, *601895,
*601275, *604660, *600752, *603820, *604192, *602207, *308230,
*600894, *312600, *603199, *604029, *602500, *102680, *235200,
#256300, *601633, #219700, 262890, *156225, *173470, *193400,
*173910, *600354, *113705, *600065, *107741, *107400, *600024,
*131195, *113811, #118220, *601638, *300011, *276903, *604144,
*311770, *601758, #173900, *604592, *120120, *179605, *603130,
*603372, *110750, *222900, *602509, *256100, *602469, *602281,
*229300, *224100, *110900, *190180, *261600, *602997, *603616,
*603189, 601791, *601567, *312700, *171060, *308700, *604027,
*162643, *516000, *176261, *604028, *314850, #145980, *601383,
*600930, *305900, *601253, *136350, *605537, *138140, *604033,
*605070, *139250, *300500, *603967, *300041, *603866, #130600,
*120150, *601050, *604942, *605204, *605248, *272750, *600163,
*604235, *600682, *107266, *306900, *191092, #262500, *600106,
*152790, *186720, *227650, *153700, *308380, *$$03390, *605646,
*164920, *604478, #252650, *173850, *173350, *602505, *246530,
*194380, *602575, *603030, #209920, *212138, #214100, *605767,
*600582, *189980, #176200, *604653, *604678, *256550, *300037,
*253700, #253300, #226700, *604766, #244400, *190000, *188040,
*604824, *214500, #237500, *232300, *605014, *604477, *190930,
*605124, *604475, *604594, #227810, *306700, #301050, *600135,
*600143, *605145, #2699$$0, *300104, *277900, *300135, *300231,
*192500, *182138, *191190, *176805, *600185, *186591, *604889,
*603051, *165360, *147545, *601040, #156575, *107269, *603009,
*602934, *123825, *60$$081, *602924, *163890, *600381, *602909,
*150330, *109690, *1$$3900, *603434, *603491, *110700, *602581,
*125647, #154700, *114760, *141900, *603690, *120220, *601199,
#145500, *601309, *602382, *120325, *600877, *604205, *604090,
601497, *602377, *605464, *138720, *603728, *120950, *604026,
*600580, *601610, *137167, *603960, *603931, *601880, *603126,
*138190, *130130, *601997, *601975, *600395, *516040, *600418,
*600650, *605245, *605172, *600509, *16476$$, *310400, *600308,
*605109, *600544, *600359, *600103, *6052$$7, *312610, *176100,
*308100, *158070, *605123, *173325, #312$$50, *600839, *158120,
#604369, *604465, *173510, #161200, *151525, *605369, *604237,
*516050, #600886, *604517, *165180, *605381, *605399, *307800,
*604365, *155740, *147795, 601709, *604673, *147730, *602122,
*147557, *193245, *600978, *604990, *603261, *603274, *601007,
*131100, *602941, *107941, *146710, *276901, *131244, *602872,
*603411, *186357, *176290, *601066, *185050, *232200, *143030,
*601843, #236700, *604122, *142800, *134638, *604985, *182380,
*603930, *142410, *137060, *604586, *601193, *120650, *252500,
*253800, *120930, *604858, *605874, 601274, *602158, *605873,
*193210, *203100, *601295, *604095, #201710, *126150, *108740,
#205400, *601373, *300167, *109545, *602894, *603361, #300257,
*266200, *603401, *131390, *180470, *605908, *604798, #221770,
*223360, *180901, *605641, *605745, *604018, *300200, *604603,
*230800, *602676, #604004, *605692, *602640, *601599, *134637,
*245900, *118425, 601614, *605725, *120110, *300189, *300035,
*603102, *250800, *602282, *602458, *123610, *603754, *300278,
*601463, *300224, *601581, *182160, *601653, *139191, *601733,
*600748, *142460, *601194, *152390, *153620, *601615, *601814,
*601617, *601613, *300191, #308300, *600798, 601858, *601872,
*601597, #601588, *600821, *147840, *152427, *138850, *600823,
*601492, *300256, *600840, *300267, *601411, *139080, *139090,
600851, *300334, *179080, *602095, *601284, *601282, #177200,
*601681, *601252, *176000, *602184, *602188, #266510, #154020,
*186711, *257200, *601711, *600667, *602241, *186745, *255125,
*300126, *600644, *123890, #255120, #175200, *600004, *302060,
*123580, *186760, *122561, *602316, *600017, *120940, 140300,
*151690, *120700, *602354, *600019, *600857, *182175, *600536,
*158380, *600516, *120290, *600493, *182310, #252010, *182530,
*186830, *601839, *142790, *159465, *118990, *250790, *248600,
#248250, *186845, *601153, *142600, *116930, *114860, *171834,
#303600, *186880, *600444, *142871, *601852, *602602, *602607,
*114207, *186910, #232220, 600880, *134635, *112203, #112100,
*111680, *231680, *311030, *111250, *111200, *134390, #226670,
#145600, *226200, *602714, *171760, *133550, *602727, *161555,
*602744, *602746, #131705, *602835, *600423, *176267, *602859,
#600918, 277175, *602874, *601020, *109770, *600170, *217070,
*173515, *602893, *147280, *154360, *171050, *108780, *176257,
*600979, *600377, *108360, *204500, *170260, *146880, *154582,
*601011, *600997, *602992, *201475, *603005, *190198, *147360,
#270400, *600238, #164970, *306250, #126600, *193065, #181350,
*106180, *602136, *600937, *603086, *603087, *307030, *182099,
*103320, *601683, #192430, *103180, *102681, *192321, *600244,
*191740, *191315, *603152, *102642, *191305, #266140, *100500,
*600867, *604585, *604404, *604345, *603201, *605430, *603207,
*603208, *605433, *604101, *603969, *605896, *604616, *605851,
*605768, *604576, *605754, *605730, *605477, *603263, *605538,
*603283, *604402, *605453, *605427, *603302, *605458, 603313,
*604415, *603345, *605541, *603353, *605295, *603879, *605268,
*605266, *605246, *603377, *603380, *605181, *604203, *603425,
*603867, *605106, *605017, *603842, *604936, *603510, *604857,
*605932, *605816, *603765, *603551, *605357, *605237, *604204,
*603594, *605110, *604190, *603861, *604962, *603639, *603644,
*605007, *605349, *604943, *604918, *604907, *603667, *603681,
*605396, *605561, *603712, *603713, *605688, *605942, *604878,
*604843, *604659, *604671, *603798, *604682, *604056, *604705,
*603749, 602586, *603647, *602515, #602475, *603717, *602359,
*602372, *602380, *602518, *603652, *602573, *603626, 602587,
*603598, *602871, *603613, *603750, *603875, *602608, *602666,
*602345, *602935, *603564, *603548, *603927, 601876, *602343,
*603943, *603787, *601730, *601611, *602679, *603788, *602243,
603790, *601535, *603796, *601488, *601485, *602314, *601478,
*604047, *604048, *602297, *604057, *602715, *602192, *601459,
*601416, *603833, *602190, *604102, *602106, *604111, *602724,
*603499, *602736, *601123, *601002, *600923, *601987, *604149,
*601929, *600910, *600900, *600864, *604165, *600782, *602836,
*600769, *600742, *602783, *601905, *600535, *604198, *601901,
*600534, *602876, *603356, *600530, *604216, *604217, *602890,
*602905, *600465, *600464, *600446, *602891, *603366, *601894,
*604272, *603926, *603312, *600368, *602914, *600327, *603151,
*603202, 602911, *602974, *603006, *601883, *603008, *600074,
*603007, *603046, #603903, *604433, *600016, *603925, *516005,
*516004, *516003, *601756, *604487, *516001, *313475, *313470,
#307810, *604527, *604528, *601745, *604551, *604555, *603243,
*603242, *603061, *603063, *603217, *300335, *300283, *300281,
*604600, *300197, *603097, *603220, *601625, *604623, *603118,
*601590, *604646, *300008, *601568, *300007, *275630, *601533,
#275200, *270200, #261550, *604031, *604683, #254800, *251100,
#242300, *604058, *604720, *240500, *233690, #232240, #226730,
*223100, *222100, #220100, *216950, *604832, 212750, 212067,
*604066, *193067, 601315, *193001, *604862, *604870, *191306,
*600385, *604879, *191191, *601296, *604914, *190181, *604119,
#188550, *604925, *188410, #601287, *604939, *188380, *604126,
*604945, *604148, *188060, *604982, *186854, *604988, *186360,
*186355, *185250, *600916, *605008, *605009, 185020, *600734,
*605024, *182331, *605032, *605033, *182305, *180903, #179800,
*179610, *605060, *179410, *178990, *176802, *605080, *176266,
*176263, *176260, *600732, *173490, *604199, *173445, *173391,
172290, *605147, *605149, *171890, *600528, *171833, *605185,
#170500, *605193, #168000, *605196, *167055, *605205, *605208,
166900, *605216, *162651, *162010, *600504, #161400, *604253,
#160800, *159460, *154540, *605254, *605261, *153634, *600429,
*153337, *600424, *605292, #604286, #152700, 152423, *152310,
*151625, *600153, *604313, *151523, *150325, *150320, *150292,
*603150, *150290, *150210, *605410, *605415, *605416, *605417,
*605421, *603149, *604349, *147940, *600282, *147880, *146928,
*146661, *600150, *146630, *142622, *600018, *605461, *138981,
*138590, *600023, *138330, *605495, *138297, *605512, *138230,
#136900, #301310, *516006, *605545, *605546, *136131, *134660,
*134350, *516002, *605589, *131235, #130050, *605625, *126455,
*126064, #125310, *605670, *604534, *125240, *123836, *123830,
*123620, *605702, #122200, *120980, *120360, *118510, *114835,
*605710, *605716, *605722, *114217, *604561, *113810, *111740,
#110800, *605748, *605752, *604564, *110600, *603160, *109610,
*605784, #107480, *107273, *603192, *300169, *106195, *105210,
*104615, *104614, *104210, *103850, 103581, *605876, *605877,
*605879, *103220, *605887, *300150, *102910, *102670, *102576,
*605916, *604629, *102575, *102573, *300132, *101800, *605947
3) Channel (Member of Membrane Protein)
[0376] 361 entries found, searching for "channel" TABLE-US-00022
*176266, *600724, *182390, *123825, *114208, *114206, *176267,
*114205, *601784, *600937, *114204, *603415, *600053, *114207,
*114209, *605427, *604527, *604528, *600760, *601011, *192500,
*118425, *600228, *176261, *602235, *600761, *600359, *300008,
*182389, *600877, *602232, *176263, *182391, *601328, *600054,
*603939, *602208, *601534, *600504, *602323, *603208, *601958,
*603537, *601012, *601327, *600734, *602780, *602781, *604433,
*603220, *182392, *605874, *605873, *601745, *603888, *603219,
*602604, *603796, *302910, *602866, *601013, *602905, *602906,
*603967, *600163, #170500, *152427, *180901, *176260, #601462,
*603951, *601141, *604492, *600702, *602023, *600308, *602754,
*107776, *176257, *602024, *601949, *605222, *601142, *602983,
*193245, *600681, *176265, *600235, *176262, *176258, *605206,
*604427, *605411, *603305, *601219, *600150, *604065, *602343,
*605223, *605720, *603906, *138249, *138253, *600843, *604385,
*600003, *600935, *603940, *602727, *602158, 602911, *600397,
*602726, *600845, *605080, *600580, *602872, *602106, *176264,
*603953, *605722, *300110, *138252, *604111, *602717, *602420,
*600570, 600844, *603493, *600932, *605716, *138254, *603652,
*300138, *605410, *176268, *605214, *605696, *300334, *604660,
*176256, *605879, *603749, *603583, *602345, *604661, *603787,
603313, *602982, *604337, *600846, *604662, *300328, *300281,
*602566, *602836, *604003, *603788, *603651, *602421, *107777,
#177200, *100725, #219700, *100690, *100710, #160800, #603830,
#183086, *600509, #220400, #601144, *173910, *180902, *605692,
#264350, #160900, #145600, #255700, *602076, *603061, *601313,
*154275, #604233, *604532, #108500, #121201, #170400, *300225,
*121014, *139311, #125800, #160120, *118503, 601439, #141500,
#168300, *304040, #601887, #256450, *186945, *154276, #300009,
#216900, *600040, *601014, *601042, *602512, *601383, *605445,
*602368, *603831, #117000, *601218, *108745, *605248, #177735,
#173900, *601212, *182139, *601059, *600039, *601485, *180903,
*186360, *603319, #600101, *118509, *600109, #121200, *600170,
*604187, *176975, *137163, #310468, #263800, #262300, *603750,
*600229, *124030, *602251, #603829, *137143, #145500, *600669,
*147450, *154050, *603353, *600516, *601157, *600855, *601154,
*602522, *249210, *600968, #252650, *171060, *600919, *156490,
#259700, #601678, *601764, #310500, *131244, *300041, *121011,
*125950, *114180, *602974, *600637, *113730, *118504, *605145,
*604669, *118800, *121013, *121015, *138491, *600421, *104610,
*604045, *604594, *131230, *605487, *138247, *600467, #602485,
*602481, *138251, *137192, *602403, 600851, *277900, *603785,
*603152, *603199, *603475, #168600, #272120, *170280, *603852,
#241200, *603053, *600465, #603034, *142461, *164920, *137164,
*600884, *600442, *123885, *604001, *600232, *232200, *171050,
*602103, *602014, *300211, *600983, *602887, *604415, *604418,
*300242, #300071, *604471, *600837, 168350, *118511, 193007,
*600300, *604654, #601820, *180297, *600046, *603853, *604678,
*604693, #604772, *118508, *603855, *605204, #254210, *182099,
*182307, #130600, *601109, *114080, *300103, *182860, *605438,
*601129, *603964, *600019, *516060, #185000, *138079, *104210,
*605818, *603418, *305990, *305450
4) Extracellular Matrix
[0377] 218 entries found, searching for "extracellular matrix"
TABLE-US-00023 *605912, *603479, *602201, *604633, *601418,
*601548, *115437, *154870, *600754, *602261, *602285, *602262,
*134797, *120361, *604629, *604871, *603321, *603320, *601807,
#154700, *116935, *185261, *120360, *185250, *605470, *603767,
*253700, *190180, *128239, *308700, *276901, *193300, *120324,
*188826, *602109, *155760, *600514, *600261, #177170, *600536,
*147557, #116920, *150240, *601313, *120140, 601614, *605158,
*120150, *120180, #200610, *605127, *193400, *192240, #173900,
*152200, #136900, *135821, #130070, *120320, *120220, *112260,
*310200, *600900, *600262, *605670, *600985, *179590, #245150,
*602574, *601463, 183850, *601211, *604241, *600758, *186745,
*604710, *602369, *602090, *190182, *192975, *602178, *230740,
*600065, *601652, *158106, *190181, *156790, #158810, *193210,
*155120, *192977, *193065, #226700, *187380, *231050, *182120,
*188060, *186355, 163200, *164010, #156550, *151510, *150370,
*253800, *156225, *150325, #194050, *150290, *216550, *147620,
*600215, *222600, *147559, *165380, *182888, *600491, *146650,
*146640, *600564, *600596, *600616, *600700, *600742, *138297,
*182889, *154705, *600930, *301870, *153619, *601050, *601090,
*601105, *165070, *305370, *135820, *130660, *310300, *601492,
*128240, *601587, #126600, *601636, *600119, *601692, *601728,
*125485, 601858, *601915, *602048, *175100, *602108, *121010,
*600245, *120470, *120328, *120325, *602264, *120280, *602366,
*600309, *602402, *602415, *602428, *602453, *602505, #166210,
*602600, *602941, *603005, *603196, 603209, *603221, *603234,
*603319, *120250, *120210, *120120, *603489, *603551, *118938,
*603799, *603842, *603924, *603963, *604042, *604063, *604149,
*604160, *601028, *604467, *604510, *604592, *116930, *116806,
*601284, *604724, *604806, *604807, *604808, *107269, *605007,
*605008, *605009, *600214, *600076, *605174, *605175, *605292,
*605343, *605351, #600204, *605497, *605546, *605587, *605623,
*600211, *605702, *103320
[0378] In addition to these, the various keywords shown in the
above-mentioned categorization or others can be used for the OMIM
search and the result may suggest the involvement thereof in
diseases.
[0379] Further, the use of nucleotide sequences of cDNAs of the
present invention enables analyzing the expression frequency of
genes corresponding to the cDNAs. In addition, functions of the
genes can be predicted based on the information obtained by the
expression frequency analysis.
[0380] There are several methods for analyzing the expression
levels of genes involved in diseases. Differences in gene
expression levels between diseased and normal tissues are studied
by the analytical methods using, for example, Northern
hybridization, RT-PCR, DNA microarray, etc. (Experimental Medicine,
Vol. 17, No. 8, 980-1056 (1999); Cell Engineering (additional
volume) DNA Microarray and Advanced PCR Methods, Muramatsu &
Nawa (eds.), Shujunsya (2000)). By computer analysis, in addition
to these analysis methods, the nucleotide sequences of expressed
genes can be compared to analyze the expression frequency. For
example, there is a database called "BODYMAP"; gene clones are
extracted at random from cDNA libraries of various tissues and/or
cells, and the clones homologous to one another are assigned to a
single cluster based on the information of nucleotide sequence
homology at the 3'-end; genes are classified into any clusters, and
the numbers of clones in the respective clusters are compared to
gain the information on expression frequency
(http://bodymap.ims.u-tokyo.ac.jp/).
[0381] When explicit difference in the expression levels between
diseased tissues and normal tissues is observed for a gene by these
analytical methods, it can be conclude that the gene is closely
involved in a disease or disorder. Instead of diseased tissues,
when gene expression is explicitly different between normal cells
and cells reproducing disease-associated specific features, it can
be concluded that the gene is closely involved in a disease or
disorder.
[0382] From the 1970 clones whose full-length nucleotide sequences
had been revealed, genes involved in particular pathology or
functions were selected by the use of databases shown below (see
Example 7; "Expression frequency analysis in silico"). The database
used in the analyses of the present invention contains nucleotide
sequences of 770,546 clones, and the population of the database is
large enough for the analysis. The sequence information in the
database was obtained by selecting cDNA clones at random from cDNA
libraries derived from the various tissues and cells shown in
Example 1 and determining the 5'-end sequences thereof.
[0383] Then, the nucleotide sequences of respective clones in this
database were categorized (clustered) based on the nucleotide
sequence homology determined with a search program; the number of
clones belonging to every cluster of each library was determined
and normalized; thus, the ratio of a certain gene in a cDNA library
was determined. This analysis provided the information of the
expression frequency of a gene in a tissue or cell that is the
source of the cDNA library.
[0384] Then, in order to analyze the expression of genes
corresponding to the nucleotide sequences of cDNAs of the present
invention in tissues and cells, the libraries from the tissues or
cells, which had been used in the large-scale cDNA analyses, were
taken as subjects to compare the expression levels between
different tissues or cells. Namely, the expression frequency was
analyzed by comparing the previously normalized values between
tissues or cells from which 600 or more cDNA clones whose
nucleotide sequences had been analyzed were derived. The result of
this analysis showed that the cDNA clones corresponded to the genes
involved in the pathology and functions, which are indicated below.
Each value in Tables 3 to 39 indicated below represents a relative
expression frequency; the higher the value, the higher the
expression level.
Osteoporosis-Related Genes
[0385] Osteoporosis is a pathology in which bones are easily broken
owing to overall decrease in components of bone. The onset
correlates to the balance between the functions of osteoblast
producing bone and osteoclast absorbing bone, namely bone
metabolism. Thus, the genes involved in the increase of osteoclasts
differentiating from precursor cells of monocyte/macrophage line
(Molecular Medicine 38. 642-648. (2001)) are genes involved in
osteoporosis relevant to bone metabolism.
[0386] A nucleotide sequence information-based analysis was carried
out to identify the genes whose expression frequencies are higher
or lower in CD34+ cell (cell expressing a glycoprotein CD34)
treated with the osteoclast differentiation factor (Molecular
Medicine 38. 642-648. (2001)) than in the untreated CD34+ cell,
which is the precursor cell of monocyte/macrophage line. The result
of comparative analysis for the frequency between the cDNA
libraries prepared from the RNA of CD34+ cells (CD34C) and from the
RNA of CD34+ cells treated with the osteoclast differentiation
factor (D30ST, D60ST or D90ST) showed that the genes whose
expression levels were different between the two were 26 clones
indicated in Table 3. These clones are involved in
osteoporosis.
Genes Involved in Neural Cell Differentiation
[0387] Genes involved in neural cell differentiation are useful for
treating neurological diseases. Genes with varying expression
levels in response to induction of cellular differentiation in
neural cells are thought to be involved in neurological
diseases.
[0388] A survey was performed for genes whose expression levels are
varied in response to induction of differentiation (stimulation by
retinoic acid (RA) or growth inhibitor treatment after RA
stimulation) in cultured cells of a neural strain, NT2. The result
of comparative analysis of cDNA libraries derived from
undifferentiated NT2 cells (NT2RM) and the cells subjected to the
differentiation treatment (NT2RP, NT2RI or NT2NE) showed that the
genes whose expression levels were different between the two were
193 clones indicated in Table 4. These genes are neurological
disease-related genes.
Cancer-Related Genes
[0389] It has been assumed that, distinct from normal tissues,
cancer tissues express a distinct set of genes, and thus the
expression thereof can contribute to the carcinogenesis in tissues
and cells. Thus, genes whose expression patterns in cancer tissues
are different from those in normal tissues are cancer-related
genes. Search was carried out for the genes whose expression levels
in cancer tissues were different from those in normal tissues.
[0390] The result of comparative analysis of cDNA libraries derived
from breast tumor (TBAES) and normal breast (BEAST) showed that the
genes whose expression levels were different between the two were 4
clones indicated in Table 5.
[0391] The result of comparative analysis of cDNA libraries derived
cervical tumor (TCERX) and normal cervical duct (CERVX) showed that
the genes whose expression levels were different between the two
was one clone indicated in Table 6.
[0392] The result of comparative analysis of cDNA libraries derived
from colon tumor (TCOLN) and normal colon (COLON) showed that the
genes whose expression levels were different between the two was
one clone indicated in Table 7.
[0393] The result of comparative analysis of cDNA libraries derived
from esophageal tumor (TESOP) and normal esophagus (NESOP) showed
that the genes whose expression levels were different between the
two were 6 clones indicated in Table 8.
[0394] The result of comparative analysis of cDNA libraries derived
from kidney tumor (TKIDN) and normal kidney (KIDNE) showed that the
genes whose expression levels were different between the two were
132 clones indicated in Table 9.
[0395] The result of comparative analysis of cDNA libraries derived
from liver tumor (TLIVE) and normal liver (LIVER) showed that the
genes whose expression levels were different between the two were
25 clones indicated in Table 10.
[0396] The result of comparative analysis of cDNA libraries derived
from lung tumor (TLUNG) and normal lung (HLUNG) showed that the
genes whose expression levels were different between the two were
99 clones indicated in Table 11.
[0397] The result of comparative analysis of cDNA libraries derived
from ovary tumor (TOVER) and normal ovary (NOVER) showed the genes
whose expression levels were different between the two were 3
clones indicated in Table 12.
[0398] The result of comparative analysis of cDNA libraries derived
from stomach tumor (TSTOM) and normal stomach (STOMA) showed that
the genes whose expression levels were different between the two
were 15 clones indicated in Table 13.
[0399] The result of comparative analysis of cDNA libraries derived
from uterine tumor (TUTER) and normal uterus (UTERU) showed that
the genes whose expression levels were different between the two
were 97 clones indicated in Table 14.
[0400] The result of comparative analysis of cDNA libraries derived
from tongue cancer (CTONG) and normal tongue (NTONG) showed that
the genes whose expression levels were different between the two
were 203 clones indicated in Table 15.
[0401] These genes are involved in cancers.
[0402] Further, there is a method to search for genes involved in
development and differentiation, which is the expression frequency
analysis in which the expression levels of genes are compared
between developing and/or differentiating tissues and/or cells and
adult tissues and/or cells. The genes involved in tissue
development and/or differentiation are genes participating in
tissue construction and expression of function, and thus are useful
genes, which are available for regenerative medicine aiming at
convenient regeneration of injured tissues.
[0403] By using the information of gene expression frequency gained
from the database of 5'-end nucleotide sequences described above,
genes involved in development or differentiation of particular
tissues were selected from the 1970 clones whose full-length
nucleotide sequence had been revealed (see Example 7).
[0404] The result of comparative analysis of cDNA libraries derived
from fetal brain (FCBBF, FEBRA or OCBBF) and adult brain (BRACE,
BRALZ, BRAMY, BRAWH, BRCAN, BRCOC, BRHIP, BRSSN, BRSTN or BRTHA)
showed that the genes whose expression levels were different
between the two were 775 clones indicated in Tables 16 to 36.
[0405] The result of comparative analysis of cDNA libraries derived
from fetal heart (FEHRT) and adult heart (HEART) showed that the
genes whose expression levels were different between the two were
28 clones indicated in Table 37.
[0406] The result of comparative analysis of cDNA libraries derived
from fetal kidney (FEKID) and adult kidney (KIDNE) showed that the
genes whose expression levels were different between the two were
95 clones indicated in Table 38.
[0407] The result of comparative analysis of cDNA libraries derived
from fetal lung (FELNG) and adult lung (HLUNG) showed that the
genes whose expression levels were different between the two were
99 clones indicated in Table 39. These genes are involved in
regeneration of tissues and/or cells.
[0408] The expression frequency or the like can be analyzed by PCR
based on the nucleotide sequences of cDNAs of the present
invention. There are some known methods for comparing the
quantities of amplification products obtained by PCR. For example,
the band intensities can be determined by ethidium bromide
staining. With R1-labeled or fluorescently labeled primers, the R1
signal or fluorescence intensity can be assayed for the quantity of
labeled amplification products. Alternatively, the quantity of
amplification products can also be determined by measuring the RI
signal or the fluorescence intensity from the RI-labeled or
fluorescently labeled probe hybridizing to the products. The assay
results thus obtained are compared and then the clones exhibiting
differences in the expression levels can be selected.
[0409] There are some quantitative PCR methods: a PCR method using
internal standards; a competitive PCR, in which the quantification
is achieved by adding, to a sample, a dilution series of a known
quantity of a template RNA and by comparing the quantity of an
amplification product derived from the RNA of interest with the
quantity of an amplification product derived from the template RNA.
These methods overcome the problems of errors in the amount of
amplification products among tubes and of the plateau effect.
ATAC-PCR (Adaptor-tagged competitive PCR) is a method of
competitive PCR which is practiced by using multiple adapters of
different sizes attached to a gene whose 3'-end nucleotide sequence
has previously been determined. The ratio of expression frequency
of a single mRNA species from a number of tissues (cells) can be
assayed in a single step (Nucleic Acids Research 1997, 25 (22):
4694-4696; "DNA Micro-array and Advanced PCR Techniques", Cell
Technology, supplement, Eds., Muramatsu and Nawa (Shujunsha, 2000):
104-112).
[0410] If it is observed, by using these analytical methods, that
the expression levels of genes are evidently varied during major
cellular events (such as differentiation and apoptosis), the genes
are involved in the cellular events and accordingly are candidates
for disease- and/or disorder-related genes. Further, genes
exhibiting tissue-specific expression are genes playing important
parts in the tissue functions and, therefore, can be candidates for
genes involved in diseases and/or disorders affecting the
tissues.
[0411] For example, inflammation is an important biological
response that is known to be involved in various diseases. The
representative inflammation-inducing factors include TNF-.alpha.
(Tumor Necrosis Factor-alpha). There exists a signaling cascade
activated by TNF-.alpha. stimulations, wherein NF-.kappa.B is a
transducing molecule (Cell 1995, 80:529-532). It has also been
revealed that many inflammation-related genes, including IL-2, IL-6
and G-CSF, are varied in the expression levels thereof in response
to the signal through the pathway (Trends Genet. 1999, 15 (6):
229-235). It is assumed that genes whose expression levels are
varied in response to the stimulation of TNF-.alpha. also
participate in inflammation.
[0412] Further, the infection of Helicobacter pylori to the gastric
epithelia is known to cause gastritis and gastroduodenal ulcer
(Mebio 2000, July, 17 (7): 16-33). Thus, the genes whose expression
levels are altered depending on co-culturing cells with
Helicobacter pylori may be involved in gastritis and gastroduodenal
ulcer. A recent study has suggested that Helicobacter pylori
strongly activates the NF-.kappa.B pathway (Gastroenterology 2000,
119: 97-108).
[0413] THP-1 cell, which is a human monocyte cell line, was
cultured in the presence of TNF-.alpha. (Tumor Necrosis
Factor-alpha). The genes whose expression levels were altered owing
to the presence of TNF-.alpha. were searched for, and the result
showed that the clones whose expression levels were increased owing
to the presence of TNF-.alpha. were TABLE-US-00024 ASTRO20055530,
ASTRO20055930, ASTRO20088950, BRAMY20027390, BRAMY20076130,
BRAMY20118410, BRAMY20125360, BRAMY20237190, BRCAN20001480,
BRHIP10000720, CD34C20001750, CTONG20078340, CTONG20085210,
DFNES20063460, FCBBF20029280, FCBBF20033360, FCBBF30078600,
FEBRA20007820, FEBRA20031280, FEBRA20031810, FEBRA20040290,
HLUNG20041540, HLUNG20092530, MESAN20021860, MESAN20067430,
MESAN20084150, NT2NE20092950, NT2RP70031070, OCBBF20012520,
OCBBF20142290, OCBBF20165900, OCBBF20170350, OCBBF20176650,
PLACE60006300, PROST20011160, PROST20106060, SPLEN20040780,
SPLEN20110860, SPLEN20177400, TESTI20030610, TESTI20043130,
TESTI20059370, TESTI20254480, THYMU10004280, THYMU20030460,
THYMU20062520, THYMU20078240, THYMU20150190, TRACH20090060,
TRACH20125620, UTERU20026620, UTERU20045200, UTERU20064120,
UTERU20103200.
[0414] On the other hand, the clones whose expression levels were
decreased owing to the presence of TNF-.alpha. were TABLE-US-00025
BNGH420052350, BRACE20052530, BRAMY20003880, CTONG20170940,
FCBBF30022680, FCBBF30225930, FCBBF30257370, FEBRA20046280,
KIDNE20084030, KIDNE20188630, NT2NE20082130, OCBBF20110210,
PLACE60061370, PROST20041460, PROST20075280, PROST20110120,
SMINT20006020, TESTI20046540, TESTI20057200, TESTI20113940,
TESTI20257910, TESTI20262940, TRACH20149740.
[0415] These clones are inflammation-related genes.
[0416] MKN45, which is a gastric cancer cell line, was co-cultured
with Helicobacter pylori. The genes whose expression levels were
altered owing to the presence of Helicobacter pylori were searched
for, and the result showed that the clones whose expression levels
were increased owing to the presence of Helicobacter pylori were
TABLE-US-00026 BRAMY20028530, BRAMY20035380, OCBBF20170350,
PROST20011160, SKMUS20091900, SPLEN20040780, THYMU20078240,
TRACH20190460, UTERU20045200, UTERU20064120, ASTRO20055530,
CTONG20170940, FEBRA20040290, MESAN20067430, PROST20016760,
THYMU10004280, TRACH20090060, UTERU20041970, OCBBF20142290,
TESTI20030610.
[0417] On the other hand, the clones whose expression levels were
decreased owing to the presence of Helicobacter pylori were
TABLE-US-00027 ASTRO20088950, BRACE20052530, BRAMY20003880,
BRAMY20027390, BRAMY20036530, BRAMY20118410, BRHIP20000210,
FCBBF20032930, FCBBF30022680, FCBBF30169870, FEBRA20182030,
KIDNE20182540, LIVER20007750, MESAN20021220, NT2NE20059210,
NT2NE20082130, OCBBF20155030, PROST20065100, PROST20075280,
SPLEN20110860, TESTI20057200, TESTI20113940, TESTI20149880,
TESTI20151800, TESTI20198600, TESTI20257910, THYMU20046770,
THYMU20058550, THYMU20150190, FCBBF20033360, FCBBF30257370,
FEBRA20098040, SMINT20006020.
[0418] These clones are involved in gastritis or gastroduodenal
ulcer.
[0419] For example, if the polypeptide encoded by the cDNA of the
present invention is a regulatory factor of cellular conditions
such as growth and differentiation, it can be used for developing
medicines as follows. The polypeptide or antibody provided by the
invention is injected into a certain kind of cells by
microinjection. Then, using the cells, it is possible to screen low
molecular weight compounds, etc. by measuring the change in the
cellular conditions, or the activation or inhibition of a
particular gene. The screening can be performed as follows.
[0420] First, the polypeptide is expressed and purified as
recombinant. The purified polypeptide is microinjected into cells
such as various cell lines, or primary culture cells, and the
cellular change such as growth and differentiation can be examined.
Alternatively, the induction of genes whose expression is known to
be involved in a particular change of cellular conditions may be
detected by the amount of mRNA or polypeptide. Alternatively, the
amount of intracellular molecules (low molecular weight compounds,
etc.) that is changed by the function of the gene product
(polypeptide) which is known to be involved in a particular change
of cellular conditions may be detected.
[0421] The compounds to be screened (both low and high molecular
compounds are acceptable) can be added to the culture media and
assessed for their activity by measuring the change of the cellular
conditions.
[0422] Instead of microinjection, cell lines introduced with the
gene obtained in the invention can be used for the screening. If
the gene product is turn out to be involved in a particular change
in the cellular conditions, the change of the product can be used
as a measurement for screening. Once a compound is screened out
which can activate or inhibit the function of the polypeptide of
the invention, it can be applied for developing medicines.
[0423] If the polypeptide encoded by the cDNA of the present
invention is a secretory protein, membrane protein, or protein
involved in signal transduction, glycoprotein, transcription, or
diseases, it can be used in functional assays for developing
medicines.
[0424] In case of a membrane protein, it is most likely to be a
polypeptide that functions as a receptor or ligand on the cell
surface. Therefore, it is possible to reveal a new relationship
between a ligand and receptor by screening the membrane protein of
the invention based on the binding activity with the known ligand
or receptor. Screening can be performed according to the known
methods.
[0425] For example, a ligand against the polypeptide of the
invention can be screened in the following manner. Namely, a ligand
that binds to a specific polypeptide can be screened by a method
comprising the steps of: (a) contacting a test sample with the
polypeptide of the invention or a partial peptide thereof, or cells
expressing these, and (b) selecting a test sample that binds to
said polypeptide, said partial peptide, or said cells.
[0426] On the other hand, for example, screening using cells
expressing the polypeptide of the present invention that is a
receptor protein can also be performed as follows. It is possible
to screen receptors that is capable of binding to a specific
polypeptide by using procedures (a) attaching the sample cells to
the polypeptide of the invention or its partial peptide, and (b)
selecting cells that can bind to the said polypeptide or its
partial peptide.
[0427] In a following screening as an example, first the
polypeptide of the invention is expressed, and the recombinant
polypeptide is purified. Next, the purified polypeptide is labeled,
binding assay is performed using a various cell lines or primary
cultured cells, and cells that are expressing a receptor are
selected (Growth and differentiation factors and their receptors,
Shin-Seikagaku Jikken Kouza Vol. 7 (1991) Honjyo, Arai, Taniguchi,
and Muramatsu edit, p203-236, Tokyo-Kagaku-Doujin). A polypeptide
of the invention can be labeled with RI such as .sup.125I, and
enzyme (alkaline phosphatase etc.).
[0428] Alternatively, a polypeptide of the invention may be used
without labeling and then detected by using a labeled antibody
against the polypeptide. The cells that are selected by the above
screening methods, which express a receptor of the polypeptide of
the invention, can be used for the further screening of an agonists
or antagonists of the said receptor.
[0429] Once the ligand binding to the polypeptide of the invention,
the receptor of the polypeptide of the invention or the cells
expressing the receptor are obtained by screening, it is possible
to screen a compound that binds to the ligand and receptor. Also it
is possible to screen a compound that can inhibit both bindings
(agonists or antagonists of the receptor, for example) by utilizing
the binding activities.
[0430] When the polypeptide of the invention is a receptor, the
screening method comprises the steps of (a) contacting the
polypeptide of the invention or cells expressing the polypeptide of
the invention with the ligand, in the presence of a test sample,
(b) detecting the binding activity between said polypeptide or
cells expressing said polypeptide and the ligand, and (c) selecting
a compound that reduces said binding activity when compared to the
activity in the absence of the test sample. Furthermore, when the
polypeptide of the invention is a ligand, the screening method
comprises the steps of (a) contacting the polypeptide of the
invention with its receptor or cells expressing the receptor in the
presence of samples, (b) detecting the binding activity between the
polypeptide and its receptor or the cells expressing the receptor,
and (c) selecting a compound that can potentially reduce the
binding activity compared to the activity in the absence of the
sample.
[0431] Samples to screen include cell extracts, expressed products
from a gene library, synthesized low molecular compound,
synthesized peptide, and natural compounds, for example, but are
not construed to be listed here. A compound that is isolated by the
above screening using a binding activity of the polypeptide of the
invention can also be used as a sample.
[0432] A compound isolated by the screening may be a candidate to
be an agonist or an antagonist of the receptor of the polypeptide.
By utilizing an assay that monitors a change in the intracellular
signaling such as phosphorylation which results from reduction of
the binding between the polypeptide and its receptor, it is
possible to identify whether the obtained compound is an agonist or
antagonist of the receptor. Also, the compound may be a candidate
of a molecule that can inhibit the interaction between the
polypeptide and its associated proteins (including a receptor) in
vivo. Such compounds can be used for developing drugs for
precaution or cures of a disease in which the polypeptide is
involved.
[0433] Secretory proteins may regulate cellular conditions such as
growth and differentiation. It is possible to find out a novel
factor that regulates cellular conditions by adding the secretory
protein of the invention to a certain kind of cell, and performing
a screening by utilizing the cellular changes in growth or
differentiation, or activation of a particular gene.
[0434] The screening can be performed, for example, as follows.
First, the polypeptide of the invention is expressed and purified
in a recombinant form. Then, the purified polypeptide is added to a
various kind of cell lines or primary cultured cells, and the
change in the cell growth and differentiation is monitored. The
induction of a particular gene that is known to be involved in a
certain cellular change is detected by the amounts of mRNA and
polypeptide. Alternatively, the amount of an intracellular molecule
(low-molecular-weight compounds, etc.) that is changed by the
function of a gene product (polypeptide) that is known to function
in a certain cellular change is used for the detection.
[0435] Once the screening reveals that the polypeptide of the
invention can regulate cellular conditions or the functions, it is
possible to apply the polypeptide as a pharmaceutical and
diagnostic medicine for related diseases by itself or by altering a
part of it into an appropriate composition.
[0436] As is above described for membrane proteins, the secretory
protein provided by the invention may be used to explore a novel
ligand-receptor interaction using a screening based on the binding
activity to a known ligand or receptor. A similar method can be
used to identify an agonist or antagonist. The resulting compounds
obtained by the methods can be a candidate of a compound that can
inhibit the interaction between the polypeptide of the invention
and an interacting molecule (including a receptor). The compounds
may be able to use as a preventive, therapeutic, and diagnostic
medicine for the diseases, in which the polypeptide may play a
certain role.
[0437] Proteins involved in signal transduction or transcription
may be a factor that affects a certain polypeptide or gene in
response to intracellular/extracellular stimuli. It is possible to
find out a novel factor that can affect a polypeptide or gene by
expressing the polypeptide provided by the invention in a certain
types of cells, and performing a screening utilizing the activation
of a certain intracellular polypeptide or gene.
[0438] The screening may be performed as follows. First, a
transformed cell line expressing the polypeptide is obtained. Then,
the transformed cell line and the untransformed original cell line
are compared for the changes in the expression of a certain gene by
detecting the amount of its mRNA or polypeptide. Alternatively, the
amount of an intracellular molecule (low molecular weight
compounds, etc.) that is changed by the function of a certain gene
product (polypeptide) may be used for the detection. Furthermore,
the change of the expression of a certain gene can be detected by
introducing a fusion gene that comprises a regulatory region of the
gene and a marker gene (luciferase, .beta.-galactosidase, etc.)
into a cell, expressing the polypeptide provided by the invention
into the cell, and estimating the activity of a marker gene product
(polypeptide).
[0439] If the polypeptide or gene of the invention is involved in
diseases, it is possible to screen a gene or compound that can
regulate its expression and/or activity either directly or
indirectly by utilizing the polypeptide of the present
invention.
[0440] For example, the polypeptide of the invention is expressed
and purified as a recombinant polypeptide. Then, the polypeptide or
gene that interacts with the polypeptide of the invention is
purified, and screened based on the binding. Alternatively, the
screening can be performed by adding with a compound of a candidate
of the inhibitor added in advance and monitoring the change of
binding activity. In another method, a transcription regulatory
region locating in the 5'-upstream of the gene encoding the
polypeptide of the invention that is capable of regulating the
expression of other genes is obtained, and fused with a marker
gene. The fusion is introduced into a cell, and the cell is added
with compounds to explore a regulatory factor of the expression of
the said gene.
[0441] The compound obtained by the screening can be used for
developing pharmaceutical and diagnostic medicines for the diseases
in which the polypeptide of the present invention is involved.
Similarly, if the regulatory factor obtained in the screening is
turn out to be a polypeptide, compounds that can newly affect the
expression or activity of the polypeptide may be used as a medicine
for the diseases in which the polypeptide of the invention is
involved.
[0442] If the polypeptide of the invention has an enzymatic
activity, regardless as to whether it is a secretory protein,
membrane protein, or proteins involved in signal transduction,
glycoprotein, transcription, or diseases, a screening may be
performed by adding a compound to the polypeptide of the invention
and monitoring the change of the compound. The enzymatic activity
may also be utilized to screen a compound that can inhibit the
activity of the polypeptide.
[0443] In a screening given as an example, the polypeptide of the
invention is expressed and the recombinant polypeptide is purified.
Then, compounds are contacted with the purified polypeptide, and
the amount of the compound and the reaction products is examined.
Alternatively, compounds that are candidates of an inhibitor are
pretreated, then a compound (substrate) that can react with the
purified polypeptide is added, and the amount of the substrate and
the reaction products is examined.
[0444] The compounds obtained in the screening may be used as a
medicine for diseases in which the polypeptide of the invention is
involved. Also they can be applied for tests that examine whether
the polypeptide of the invention functions normally in vivo.
[0445] Whether the secretory protein, membrane protein, signal
transduction-related protein, glycoprotein-related protein, or
transcription-related protein of the present invention is a novel
protein involved in diseases or not is determined in another method
than described above, by obtaining a specific antibody against the
polypeptide of the invention, and examining the relationship
between the expression or activity of the polypeptide and a certain
disease. In an alternative way, it may be analyzed referred to the
methods in "Molecular Diagnosis of Genetic Diseases" (Elles R.
edit, (1996) in the series of "Method in Molecular Biology" (Humana
Press).
[0446] Proteins involved in diseases are targets of screening as
mentioned, and thus are very useful in developing drugs which
regulate their expression and activity. Also, the proteins are
useful in the medicinal industry as a diagnostic marker of the
related disease or a target of gene therapy.
[0447] Compounds isolated as mentioned above can be administered
patients as it is, or after formulated into a pharmaceutical
composition according to the known methods. For example, a
pharmaceutically acceptable carrier or vehicle, specifically
sterilized water, saline, plant oil, emulsifier, or suspending
agent can be mixed with the compounds appropriately. The
pharmaceutical compositions can be administered to patients by a
method known to those skilled in the art, such as intraarterial,
intravenous, or subcutaneous injections. The dosage may vary
depending on the weight or age of a patient, or the method of
administration, but those skilled in the art can choose an
appropriate dosage properly. If the compound is encoded by
polynucleotide, the polynucleotide can be cloned into a vector for
gene therapy, and used for gene therapy. The dosage of the
polynucleotide and the method of its administration may vary
depending on the weight or age of a patient, or the symptoms, but
those skilled in the art can choose properly.
[0448] The present invention further relates to databases
comprising at least a sequence of polynucleotide and/or
polypeptide, or a medium recorded in such databases, selected from
the sequence data of the nucleotide and/or the amino acids
indicated in Table 1. The term "database" means a set of
accumulated information as machine-searchable and readable
information of nucleotide sequence. The databases of the present
invention comprise at least one of the novel nucleotide sequences
of polynucleotides provided by the present invention. The databases
of the present invention can consist of only the sequence data of
the novel polynucleotides provided by the present invention or can
comprise other information on nucleotide sequences of known
full-length cDNAs or ESTs. The databases of the present invention
can be comprised of not only the information on the nucleotide
sequences but also the information on the gene functions revealed
by the present invention. Additional information such as names of
DNA clones carrying the full-length cDNAs can be recorded or linked
together with the sequence data in the databases.
[0449] The database of the present invention is useful for gaining
complete gene sequence information from partial sequence
information of a gene of interest. The database of the present
invention comprises nucleotide sequence information of full-length
cDNAs. Consequently, by comparing the information in this database
with the nucleotide sequence of a partial gene fragment yielded by
differential display method or subtraction method, the information
on the full-length nucleotide sequence of interest can be gained
from the sequence of the partial fragment as a starting clue.
[0450] The sequence information of the full-length cDNAs
constituting the database of the present invention contains not
only the information on the complete sequences but also extra
information on expression frequency of the genes as well as
homology of the genes to known genes and known polypeptides. Thus
the extra information facilitates rapid functional analyses of
partial gene fragments. Further, the information on human genes is
accumulated in the database of the present invention, and
therefore, the database is useful for isolating a human homologue
of a gene originating from other species. The human homologue can
be isolated based on the nucleotide sequence of the gene from the
original species.
[0451] At present, information on a wide variety of gene fragments
can be obtained by differential display method and subtraction
method. In general, these gene fragments are utilized as tools for
isolating the full-length sequences thereof. When the gene fragment
corresponds to an already-known gene, the full-length sequence is
easily obtained by comparing the partial sequence with the
information in known databases. However, when there exists no
information corresponding to the partial sequence of interest in
the known databases, cDNA cloning should be carried out for the
full-length cDNA. It is often difficult to obtain the full-length
nucleotide sequence using the partial sequence information as an
initial clue. If the full-length of the gene is not available, the
amino acid sequence of the polypeptide encoded by the gene remains
unidentified. Thus the database of the present invention can
contribute to the identification of full-length cDNAs corresponding
to gene fragments, which cannot be revealed by using databases of
known genes.
[0452] The present invention has provided 1970 polynucleotides. As
has not yet proceeded the isolation of full-length cDNA within the
human, the invention has great significance. It is known that
secretory proteins, membrane proteins, signal transduction-related
proteins, glycoprotein-related proteins, transcription-related
proteins, and so on are involved in many diseases. The genes and
proteins involved in diseases are useful for developing a
diagnostic marker or medicines for regulation of their expression
and activity, or as a target of gene therapy.
[0453] In particular, cDNA assumed to encode secretory proteins,
which were provided by this invention, are very important for the
industry since the encoded proteins themselves are expected to be
useful as pharmaceutical agents and many disease-related genes may
be included in them. In addition, membrane proteins, signal
transduction-related proteins, transcription-related proteins,
disease-related proteins, and genes encoding them can be used as
indicators for diseases, etc. These cDNA are also very important
for the industry, which are expected to regulate the activity or
expression of the encoded protein to treat diseases, etc.
[0454] Any patents, patent applications, and publications cited
herein are incorporated by reference.
[0455] The invention is illustrated more specifically with
reference to the following examples, but is not to be construed as
being limited thereto.
EXAMPLE 1
Preparation of cDNA Library by Oligo-Capping
(1) Extraction and Purchase of mRNA
[0456] Total RNAs as mRNA sources were extracted from human tissues
(shown below) by the method as described in the reference (J.
Sambrook, E. F. Fritsch & T. Maniatis, Molecular Cloning Second
edition, Cold Spring harbor Laboratory Press, 1989). Further, by
the method as described in the reference (J. Sambrook, E. F.
Fritsch & T. Maniatis, Molecular Cloning Second edition, Cold
Spring harbor Laboratory Press, 1989), total RNAs as mRNA sources
were extracted from human culture cells and human primary culture
cells (shown below) which had been cultivated by the methods
described in the catalogs.
[0457] The library names and the origins are indicated below in the
order of "Library name: Origin". When a library was prepared by the
subtraction method, the item is followed by a description of how to
prepare the subtracted library.
<Extraction of mRNA from Human Tissues>
[0458] NTONG: Normal tongue; [0459] CTONG: Tongue cancer; [0460]
FCBBF: Fetal brain; [0461] OCBBF: Fetal brain; [0462] PLACE:
Placenta; [0463] SYNOV: Synovial membrane tissue (from rheumatioid
arthritis). <Extraction of mRNA from Culture Cells> [0464]
BNGH4: H4 cells (ATCC #HTB-148); [0465] IMR32: IMR32 cells (ATCC
#CCL-127); [0466] SKNMC: SK-N-MC cells (ATCC #HTB-10); [0467]
3NB69: NB69 cells (RCB #RCB0480); [0468] BGGI1: GI1 cells (RCB
#RCB0763); [0469] NB9N4: NB9 cells (RCB #RCB0477); [0470] SKNSH:
SK-N-SH cells (RCB #RCB0426); [0471] NT2RM: NT2 cells (STARATAGENE
#204101); [0472] NT2RP: NT2 cells treated with retinoic acid (RA)
for 5 weeks to induce the differentiation; [0473] NT2R1: NT2 cells
treated with RA for 5 weeks to induce the differentiation, followed
by the treatment with the growth inhibitor for 2 weeks; [0474]
NT2NE: NT2 cells were treated with RA and the growth inhibitor for
the neuronal differentiation, and the resultant neurons were
concentrated and harvested (NT2 Neuron); [0475] NTISM: NT2 cells
(STARATAGENE #204101) were treated with RA for 5 weeks to induce
the differentiation, and then treated with the growth inhibitor for
2 weeks; mRNA was prepared from the cells and a cDNA library was
constructed from the mRNA; the cDNAs of the library whose
nucleotide sequences were shared by those of mRNAs from
undifferentiated NT2 cells were subtracted by using a Subtract Kit
(Invitrogen #K4320-01); the subtracted library (NT2R1-NT2RM) was
provided by this procedure.
[0476] RCB indicates that the cell was provided by the Cell Bank,
RIKEN GENE BANK, The Institute of Physical and Chemical Research;
ATCC indicates that the cell was provided by American Type Culture
Collection.
<Extraction of mRNA from Primary Culture Cells>
[0477] ASTRO: Normal human astrocyte NHA5732, Takara Shuzo #CC2565;
[0478] DFNES: Normal human dermal fibroblast (neonatal skin);
NHDF-Neo NHDF2564, Takara Shuzo #CC2509; [0479] MESAN: Normal human
mesangial cell NHMC56046-2, Takara Shuzo #CC2559; [0480] NHNPC:
Normal human neural progenitor cell NHNP5958, Takara Shuzo #CC2599;
[0481] PEBLM: Normal human peripheral blood mononuclear cell
HPBMC5939, Takara Shuzo #CC2702; [0482] HSYRA: Human synoviocyte
HS-RA (from rheumatioid arthritis), Toyobo #T404K-05; [0483] PUAEN:
Normal human pulmonary artery endothelial cells, Toyobo #T302K-05;
[0484] UMVEN: Normal human umbilical vein endothelial cell HUVEC,
Toyobo #T200K-05; [0485] HCASM: Normal human coronary artery smooth
muscle cell HCASMC, Toyobo #T305K-05; [0486] HCHON: Normal human
chondrocyte HC, Toyobo #T402K-05; [0487] HHDPC: Normal human dermal
papilla cell HDPC, Toyobo #THPCK-001; [0488] CD34C: CD34+ cells
(AllCells, LLC #CB14435M); [0489] D30ST: CD34+ cells treated with
the osteoclast differentiation factor (ODF) for 3 days to induce
the differentiation; [0490] D60ST: CD34+ cells treated with ODF for
6 days to induce the differentiation; [0491] D90ST: CD34+ cells
treated with ODF for 9 days to induce the differentiation.
[0492] Then, total RNAs extracted from the following human tissues
were purchased and used as mRNA sources. The library names and the
origins are indicated below in the order of "Library name: Origin".
When a library was prepared by the subtraction method, the item is
followed by a description of how to prepare the subtracted
library.
<Purchase of Total RNA Containing mRNA Extracted from Human
Tissues>
[0493] ADRGL: Adrenal gland, CLONTECH #64016-1; [0494] BRACE: Brain
(cerebellum), CLONTECH #64035-1; [0495] BRAWH: Whole brain,
CLONTECH #64020-1; [0496] FEBRA: Fetal brain, CLONTECH #64019-1;
[0497] FELIV: Fetal liver, CLONTECH #64018-1; [0498] HEART: Heart,
CLONTECH #64025-1; [0499] HLUNG: Lung, CLONTECH #64023-1; [0500]
KIDNE: Kidney, CLONTECH #64030-1; [0501] LIVER: Liver, CLONTECH
#64022-1; [0502] MAMGL: Mammary Gland, CLONTECH #64037-1; [0503]
PANCR: Pancreas, CLONTECH #64031-1; [0504] PROST: Prostate,
CLONTECH #64038-1; [0505] SALGL: Salivary Gland, CLONTECH #64026-1;
[0506] SKMUS: Skeletal Muscle, CLONTECH #64033-1; [0507] SMINT:
Small Intestine, CLONTECH #64039-1; [0508] SPLEN: Spleen, CLONTECH
#64034-1; [0509] STOMA: Stomach, CLONTECH #64090-1; [0510] TBAES:
Breast (Tumor), CLONTECH #64015-1; [0511] TCERX: Cervix (Tumor),
CLONTECH #64010-1; [0512] TCOLN: Colon (Tumor), CLONTECH #64014-1;
[0513] TESTI: Testis, CLONTECH #64027-1; [0514] THYMU: Thymus,
CLONTECH #64028-1; [0515] TLUNG: Lung (Tumor), CLONTECH #64013-1;
[0516] TOVAR: Ovary (Tumor), CLONTECH #64011-1; [0517] TRACH:
Trachea, CLONTECH #64091-1; [0518] TUTER: Uterus (Tumor), CLONTECH
#64008-1; [0519] UTERU: Uterus, CLONTECH #64029-1; [0520] ADIPS:
Adipose, Invitrogen #D6005-01; [0521] BLADE: Bladder, Invitrogen
#D6020-01; [0522] BRALZ: Cerebral cortex from an Alzheimer patient
(Brain, cortex, Alzheimer), Invitrogen #D6830-01; [0523] CERVX:
Cervix, Invitrogen #D6047-01; [0524] COLON: Colon, Invitrogen
#D6050-0; [0525] NESOP: Esophagus, Invitrogen #D6060-01; [0526]
PERIC: Pericardium, Invitrogen #D6105-01; [0527] RECTM: Rectum,
Invitrogen #D6110-01; [0528] TESOP: Esophageal (Tumor), Invitrogen
#D6860-01; [0529] TKIDN: Kidney (Tumor), Invitrogen #D6870-01;
[0530] TLIVE: Liver (Tumor), Invitrogen #D6880-01; [0531] TSTOM:
Stomach (Tumor), Invitrogen #D6920-01; [0532] BEAST: Adult breast,
STARATAGENE #735044; [0533] FEHRT: Fetal heart, STARATAGENE
#738012; [0534] FEKID: Fetal kidney, STARATAGENE #738014; [0535]
FELNG: Fetal lung, STARATAGENE #738020; [0536] NOVAR: Adult ovary,
STARATAGENE #735260; [0537] BRASW: subtracted library
(BRALZ-BRAWH). A cDNA library was constructed from mRNA prepared
from tissues of cerebral cortex obtained from an Alzheimer patient
[BRALZ: Cerebral cortex from an Alzheimer patient (Brain, cortex,
Alzheimer), Invitrogen #D6830-01]; the cDNAs of this library whose
nucleotide sequences were shared by those of mRNAs from whole brain
tissue [BRAWH: Whole brain, CLONTECH #64020-1] were subtracted by
using a Subtract Kit (Invitrogen #K4320-01).
[0538] Further, mRNAs extracted and purified as poly A(+) RNAs from
the human tissues shown below were purchased. A cDNA library was
prepared from an RNA mixture in which the poly A(+) RNA from each
tissue had been combined with poly A(-) RNA. The poly A(-) RNA was
prepared by removing poly A(+) RNA from the total RNA of whole
brain tissue (CLONTECH #64020-1) by using oligo dT cellulose. The
library names and the origins are indicated below in the order of
"Library name: Origin".
<Purchase of mRNAs of Human Tissues as Poly A(+) RNAs>
[0539] BRAMY: Brain (amygdala), CLONTECH #6574-1; [0540] BRCAN:
Brain (caudate nucleus), CLONTECH #6575-1; [0541] BRCOC: Brain
(corpus callosum), CLONTECH #6577-1; [0542] BRHIP: Brain
(hippocampus), CLONTECH #6578-1; [0543] BRSSN: Brain (substantia
nigra), CLONTECH #6580-1; [0544] BRSTN: Brain (subthalamic
nucleus), CLONTECH #6581-1; [0545] BRTHA: Brain (thalamus),
CLONTECH #6582-1. (2) Preparation of cDNA Library
[0546] cDNA library was prepared from each RNA by the improved
method (WO 01/04286) of oligo capping [M. Maruyama and S. Sugano,
Gene, 138: 171-174 (1994)]. A series of procedures, BAP (Bacterial
Alkaline Phosphatase) treatment, TAP (Tobacco Acid Pyrophosphatase)
treatment, RNA ligation, first strand cDNA synthesis and RNA
removal, were carried out using the oligo-cap linker (SEQ ID NO:
4093) and oligo dT primer (SEQ ID NO: 4094), as described in WO
01/04286. Then, the single-stranded cDNA was converted to a
double-stranded cDNA by PCR (polymerase chain reaction) using 5'
(SEQ ID NO: 4095) and 3' (SEQ ID NO: 4096) PCR primers, and then
digested with SfiI. Then, a fraction of cDNA fragments, typically
2-kb or longer (3-kb or longer in some cases), was unidirectionally
cloned into a DraIII-digested pME18SFL3 vector (FIG. 1) (GenBank
AB009864, Expression vector); the cDNA library was thus
prepared.
[0547] The names of cDNA libraries, which were used in the analysis
of full-length cDNA sequences, and their origins are shown in Table
2. TABLE-US-00028 TABLE 2 Library Type Origin, etc. ADRGL Tissue
Adrenal gland (CLONTECH #64016-1) ASTRO Primary Normal Human
Astrocyte NHA5732 (Takara Shuzo #CC2565) culture cell BGGI1 Culture
cell GI1 cells (RCB #RCB0763) BNGH4 Culture cell H4 cells (ATCC
#HTB-148) BRACE Tissue Brain, cerebellum (CLONTECH #64035-1) BRAMY
Tissue Brain, amygdala (CLONTECH #6574-1) BRAWH Tissue Brain, whole
(CLONTECH #64020-1) BRCAN Tissue Brain, caudate nucleus (CLONTECH
#6575-1) BRCOC Tissue Brain, corpus callosum (CLONTECH #6577-1)
BRHIP Tissue Brain, hippocampus (CLONTECH #6578-1) BRSSN Tissue
Brain, substantia nigra (CLONTECH #6580-1) CD34C Primary CD34+
cells (AllCells, LLC #CB14435M) culture cell CTONG Tissue Tongue,
Cancer DFNES Primary Normal Human Dermal Fibroblasts (Neonatal
Skin): NHDF-Neo culture cell NHDF2564 (Takara Shuzo #CC2509) FCBBF
Tissue Brain, Fetal FEBRA Tissue Brain, Fetal (CLONTECH #64019-1)
HCHON Primary Human Chondrocytes HC (Toyobo #T402K-05) culture cell
HEART Tissue Heart (CLONTECH #64025-1) HHDPC Primary Human dermal
papilla cells HDPC (Toyobo #THPCK-001) culture cell HLUNG Tissue
Lung (CLONTECH #64023-1) KIDNE Tissue Kidney (CLONTECH #64030-1)
LIVER Tissue Liver (CLONTECH #64022-1) MESAN Primary Normal human
mesangial cells NHMC56046-2 (Takara Shuzo culture cell #CC2559)
NESOP Tissue Esophagus (Invitrogen #D6060-01) NT2NE Culture cell
NT2 cells concentrated after differentiation (NT2 Neuron) NT2RI
Culture cell NT2 cells treated by growth inhibitor for 2 weeks
after RA induction for 5 weeks NT2RP Culture cell NT2 cells treated
by RA for 5 weeks NTONG Tissue Tongue OCBBF Tissue Brain, Fetal
PANCR Tissue Pancreas (CLONTECH #64031-1) PEBLM Primary Human
peripheral blood mononuclear cells HPBMC5939 culture cell (Takara
Shuzo #CC2102) PLACE Tissue Placenta PROST Tissue Prostate
(CLONTECH #64038-1) PUAEN Primary Human pulmonary artery
endothelial cells (Toyobo #T302K-05) culture cell SALGL Tissue
Salivary Gland (CLONTECH #64026-1) SKMUS Tissue Skeletal Muscle
(CLONTECH #64033-1) SKNMC Culture cell SK-N-MC cells (ATCC #HTB-10)
SKNSH Culture cell SK-N-SH cells (RCB #RCB0426) SMINT Tissue Small
Intestine (CLONTECH #64039-1) SPLEN Tissue Spleen (CLONTECH
#64034-1) TESOP Tissue Esophageal, Tumor (Invitrogen #D6860-01)
TESTI Tissue Testis (CLONTECH #64027-1) THYMU Tissue Thymus
(CLONTECH #64028-1) TKIDN Tissue Kidney, Tumor (Invitrogen
#D6870-01) TRACH Tissue Trachea (CLONTECH #64091-1) UMVEN Primary
Human umbilical vein endothelial cells HUVEC (Toyobo culture cell
#T200K-05) UTERU Tissue Uterus (CLONTECH #64029-1)
[0548] The cDNA library with the high fullness ratio (the fullness
ratio of 5'-end, which was calculated for each cDNA library by
using the protein coding region found in known mRNA species as an
index, was 90% in average) prepared by the improved oligo-capping
method was constructed by using a eukaryotic expression vector
pME18SFL3. The vector contains SR.alpha. promoter and SV40 small t
intron in the upstream of the cloning site, and SV40 polyA added
signal sequence site in the downstream. As the cloning site of
pME18SFL3 has asymmetrical DraIII sites, and the ends of cDNA
fragments contain SfiI sites complementary to the DraIII sites, the
cloned cDNA fragments can be inserted into the downstream of the
SR.alpha. promoter unidirectionally. Therefore, clones containing
full-length cDNA can be expressed transiently by introducing the
obtained plasmid directly into COS cells, etc. Thus, the clones can
be analyzed very easily in terms of the proteins that are the gene
products of the clones, or in terms of the biological activities of
the proteins.
(3) Assessment of the 5'-end Completeness of Clones Derived from
the cDNA Library Prepared by Oligo-Capping
[0549] With respect to the plasmid DNAs of clones derived from the
libraries, the nucleotide sequences of cDNA 5'-ends (3'-ends as
well in some cases) were determined in a DNA sequencer (ABI PRISM
3700, PE Biosystems), after sequencing reaction was conducted by
using a DNA sequencing reagent (BigDye Terminator Cycle Sequencing
FS Ready Reaction Kit, PE Biosystems) according to the manual. A
database was constructed based on the obtained data.
[0550] The 5'-end completeness of about 770,000 clones derived from
the human cDNA libraries prepared by the improved oligo-capping
method was determined by the following method. The clones whose
5'-end sequences were consistent with those of known human mRNA in
the public database were judged to be "full-length" if they had a
longer 5'-end sequence than that of the known human mRNA; or even
though the 5'-end sequence was shorter, if it contained the
translation initiation codon it was judged to have the
"full-length" sequence. Clones which did not contain the
translation initiation codon were judged to be "not-full-length".
The fullness ratio ((the number of full-length clones)/(the number
of full-length and not-full-length clones)) at the 5'-end of the
cDNA clones was determined by comparing with known human mRNA. As a
result, the fullness ratio of the 5'-ends was 90%. The result
indicates that the fullness ratio at the 5'-end sequence was
extremely high in the human cDNA clones obtained by the
oligo-capping method.
EXAMPLE 2
Sequencing Analysis of cDNA Ends and Selection of Full-Length
Clones
[0551] With respect to the plasmid DNAs of clones obtained from
each cDNA library, the 5'-end nucleotide sequences of the cDNAs
were determined in a DNA sequencer (ABI PRISM 3700, PE Biosystems),
after sequencing reaction was conducted by using a DNA sequencing
reagent (Dye Terminator Cycle Sequencing FS Ready Reaction Kit,
dRhodamine Terminator Cycle Sequencing FS Ready Reaction Kit or
BigDye Terminator Cycle Sequencing FS Ready Reaction Kit, PE
Biosystems) according to the manual. A database was constructed
using the data obtained.
[0552] For the analyzed 5'-end sequences of cDNA clones, the data
with the annotation of "complete cds" in the GenBank and UniGene
were searched by BLAST homology search. When identical to certain
human mRNA sequences, such cDNA clones were excluded. Then,
clustering was carried out. When the identity was 90% or higher,
and the length of consensus sequence was 50 base pairs or longer,
the cDNA clones were assumed to belong to an identical cluster, and
thus clustered. cDNA clones longer in the 5' direction were
selected from the members belonging to a cluster; if required, the
31-end sequences of the selected clones were determined by the same
analysis method as used to determine the 5'-end sequences. The data
of the end sequences obtained were analyzed, and then the clones
forming a sequence contig at 5'- and 3'-ends were excluded.
Further, as mentioned above, the data was analyzed again by BLAST
homology search; when identical to certain human mRNA sequences
(including sequences patented and applied for), the cDNA clones
were excluded. Thus, the cDNAs clones to be analyzed for their
nucleotide sequence were obtained.
EXAMPLE 3
Analysis of the Full-Length Nucleotide Sequences
[0553] The full-length nucleotide sequences of the selected clones
were determined. The nucleotide sequence determination was mainly
performed by primer walking method comprising the dideoxy
terminator method using custom-made synthetic DNA primers. Namely,
the nucleotide sequences of the DNAs were determined in a sequencer
from PE Biosystems, after sequencing reaction was carried out with
a DNA sequencing reagent from the same supplier using the
custom-made synthetic DNA primers according to the manual. A part
of the clones were analyzed with a DNA sequencer from Licor.
[0554] Further, the nucleotide sequences of a part of the clones
were determined by the shotgun method where the plasmids containing
the cDNAs were digested at random were used, instead of the use of
custom-made primers, by the same method in the DNA sequencer. The
full-length nucleotide sequences were finally determined by
completely assembling the partial nucleotide sequences obtained by
the above method.
[0555] Then, the regions translatable to proteins were deduced from
the determined full-length nucleotide sequences, and thereby the
amino acid sequences were determined. SEQ ID NOs corresponding to
the respective sequences are shown in Table 1.
EXAMPLE 4
Functional Prediction by Homology Search
[0556] For the determined nucleotide sequences, GenBank, SwissProt,
UniGene, and nr were searched by BLAST. The clones exhibiting
higher homology, which were convenient to predict their functions
based on the nucleotide sequences and deduced amino acid sequences,
were selected based on the BLAST search hit data whose P value or E
value was 10.sup.-4 or lower and for which the length of consensus
sequence.times.homology=30 or higher in the amino acid database
search. Further, from them, representative clones were selected,
which are shown as Homology Search Result Data in the last part
herein. Accordingly, the data shown herein are merely the
representative data, and the molecule exhibiting homology to each
clone is not limited thereto. Further, with respect to a part of
clones, the BLAST search hit data that did not meet the criteria as
described above are not shown herein.
EXAMPLE 5
Search for Signal Sequence, Transmembrane Domain and Other
Functional Domains in the Deduced Amino Acid Sequences
[0557] With respect to the amino acid sequences deduced from the
full-length nucleotide sequences, the prediction was made for the
presence of signal sequence at the amino terminus, the presence of
transmembrane domain, and the presence of functional protein
domains (motifs). The signal sequence at the amino terminus was
searched for by PSORT [K. Nakai & M. Kanehisa, Genomics, 14:
897-911 (1992)]; the transmembrane domain, by SOSUI [T. Hirokawa et
al., Bioinformatics, 14: 378-379 (1998)] (Mitsui Knowledge
Industry); the function domain, by Pfam
(http://www.sanger.ac.uk/Software/Pfam/index.shtml). The amino acid
sequence in which the signal sequence at the amino terminus or
transmembrane domain had been predicted to be present by PSORT or
SOSUI were assumed to be a secretory or membrane protein. Further,
when the amino acid sequence hit a certain functional domain by the
Pfam functional domain search, the protein function can be
predicted based on the hit data, for example, by referring to the
function categories on the PROSITE
(http://www.expasy.ch/cgi-bin/prosite-list.pl). In addition, the
functional domain search can also be carried out on the
PROSITE.
[0558] The search results obtained with the respective programs are
shown below.
[0559] The clones whose deduced amino acid sequences were detected
to have the signal sequences by PSORT are as follows.
TABLE-US-00029 ADRGL20021910, ADRGL20036380, ADRGL20063770,
ASTRO20020240, BNGH420052350, BNGH420077980, BRACE20054080,
BRACE20194670, BRAMY20044920, BRAMY20047560, BRAMY20137360,
BRAMY20204270, BRAMY20237190, BRAMY20251750, BRAWH20020470,
BRAWH20093070, BRCAN10001680, BRHIP10000720, BRSSN20091190,
CD34C20001750, CTONG20059130, CTONG20069320, FCBBF30062490,
FCBBF30132660, FEBRA20039260, FEBRA20040230, FEBRA20040560,
FEBRA20046280, FEBRA20182030, HCHON10001660, HCHON20015050,
HEART10001490, HHDPC20088160, HLUNG20032460, HLUNG20034970,
HLUNG20050760, HLUNG20081390, HLUNG20088750, KIDNE20134130,
KIDNE20143200, LIVER20007750, LIVER20010510, MESAN20021220,
MESAN20027900, MESAN20095220, NT2NE20069580, NT2NE20082130,
NT2NE20167660, NT2RP70003110, OCBBF20000740, OCBBF20012520,
OCBBF20110730, OCBBF20118720, OCBBF20155030, OCBBF20170350,
OCBBF20191950, PANCR10000860, PEBLM20001800, PLACE60004260,
PLACE60006300, PLACE60055590, PLACE60056910, PLACE60057860,
PLACE60104630, PLACE60184870, PROST20050390, PROST20084680,
PROST20105450, PROST20106060, PR0ST20110120, SKMUS20091900,
SKNMC20006350, SMINT20024140, SMINT20028840, SMINT20086250,
SMINT20088440, SMINT20088690, SPLEN20017810, SPLEN20073880,
SPLEN20080070, SPLEN20101950, SPLEN20108000, SPLEN20110860,
SPLEN20118050, SPLEN20138600, SPLEN20139100, SPLEN20193230,
SPLEN20193490, SPLEN20201830, TESTI20043130, TESTI20047370,
TESTI20057200, TESTI20059080, TESTI20061200, TESTI20063330,
TESTI20063600, TESTI20102390, TESTI20116120, TESTI20151800,
TESTI20166670, TESTI20210030, TESTI20245860, THYMU20020800,
THYMU20046770, THYMU20050010, THYMU20054800, THYMU20055740,
THYMU20083390, THYMU20115380, TRACH20081270, TRACH20159390,
UTERU20040150, UTERU20064120, UTERU20086530, UTERU20127150
[0560] The clones whose deduced amino acid sequences were detected
to have the transmembrane domains by SOSUI are as follows. Numerals
indicate the numbers of transmembrane domains detected in the
deduced amino acid sequences. Of the search result, the clone name
and the number of transmembrane domains are demarcated by a double
slash mark (//). TABLE-US-00030 ADRGL20020290//10,
ADRGL20021910//2, ADRGL20063770//2, ASTRO20010010//4,
ASTRO20045840//3, ASTRO20053430//1, ASTRO20055530//1,
ASTRO20055570//2, ASTRO20055930//2, ASTRO20075150//1,
ASTRO20088950//1, ASTRO20091180//4, BNGH420021680//1,
BNGH420023870//1, BNGH420052350//1, BNGH420059680//1,
BNGH420075940//1, BNGH420087430//3, BRACE10000510//2,
BRACE20052530//1, BRACE20066360//3, BRACE20068710//1,
BRACE20069000//5, BRACE20069110//1, BRAMY10001730//1,
BRAMY20001510//1, BRAMY20003880//1, BRAMY20024790//2,
BRAMY20027390//2, BRAMY20028530//2, BRAMY20035380//2,
BRAMY20045210//1, BRAMY20050940//3, BRAMY20053910//2,
BRAMY20055760//5, BRAMY20072440//8, BRAMY20083820//2,
BRAMY20089770//1, BRAMY20096930//1, BRAMY20118410//1,
BRAMY20123400//2, BRAMY20125550//1, BRAMY20127310//1,
BRAMY20127760//1, BRAMY20135720//3, BRAMY20139440//5,
BRAMY20152510//1, BRAMY20194680//2, BRAMY20204270//1,
BRAMY20225320//2, BRAMY20237190//1, BRAMY20251750//1,
BRAMY20285650//2, BRAWH20020470//7, BRAWH20026010//1,
BRAWH20030000//2, BRAWH20039640//2, BRAWH20055330//1,
BRAWH20078620//2, BRAWH20093040//3, BRAWH20185270//5,
BRAWH20190550//1, BRCAN10000760//10, BRCAN20001480//3,
BRCAN20004180//1, BRCOC20000470//2, BRCOC20003600//1,
BRHIP10001040//5, BRHIP20000210//1, BRSSN20001970//4,
BRSSN20074640//2, CD34C20001750//1, CTONG20017490//1,
CTONG20029030//4, CTONG20041260//9, CTONG20044870//2,
CTONG20045500//2, CTONG20049480//3, CTONG20051450//1,
CTONG20056150//2, CTONG20059130//6, CTONG20060040//1,
CTONG20065680//1, CTONG20071680//13, CTONG20076810//1,
CTONG20078340//2, CTONG20079590//1, CTONG20083980//1,
CTONG20084020//2, CTONG20167750//1, CTONG20168240//3,
CTONG20179890//5, CTONG20183830//1, DFNES20018000//2,
DFNES20028170//1, DFNES20029660//8, DFNES20072990//9,
DFNES20080880//1, FCBBF20018680//3, FCBBF20029280//2,
FCBBF20032930//1, FCBBF20036360//2, FCBBF20054390//2,
FCBBF30022680//1, FCBBF30042610//7, FCBBF30062490//2,
FCBBF30075970//1, FCBBF30078600//3, FCBBF30095410//1,
FCBBF30105440//3, FCBBF30118670//1, FCBBF30145670//1,
FCBBF30164510//1, FCBBF30169870//1, FCBBF30172330//1,
FCBBF30177290//2, FCBBF30179740//1, FCBBF30195690//2,
FCBBF30197840//1, FCBBF30212210//1, FCBBF30223110//1,
FCBBF30225930//9, FCBBF30230610//1, FCBBF30260480//5,
FCBBF30266510//3, FCBBF30287940//1, FCBBF50000610//2,
FCBBF50004950//3, FEBRA20007820//4, FEBRA20018670//2,
FEBRA20031280//7, FEBRA20031810//2, FEBRA20040560//4,
FEBRA20057010//1, FEBRA20080860//1, FEBRA20084750//1,
FEBRA20115930//10, FEBRA20116650//4, FEBRA20121950//5,
FEBRA20141980//1, FEBRA20177800//1, FEBRA20182030//1,
HCHON20015050//1, HEART20031680//1, HHDPC10001140//1,
HHDPC20051850//1, HHDPC20082790//3, HHDPC20088160//1,
HLUNG20015070//2, HLUNG20020850//2, HLUNG20029490//1,
HLUNG20032460//1, HLUNG20033350//2, HLUNG20037160//2,
HLUNG20050760//1, HLUNG20052300//1, HLUNG20060670//1,
HLUNG20065990//1, HLUNG20074330//1, HLUNG20081390//2,
HLUNG20092530//1, KIDNE20016360//5, KIDNE20083150//3,
KIDNE20084030//12, KIDNE20084800//2, KIDNE20086490//1,
KIDNE20086660//2, KIDNE20094670//1, KIDNE20142900//1,
KIDNE20148080//1, KIDNE20160960//2, KIDNE20163710//1,
KIDNE20169180//2, KIDNE20182540//3, KIDNE20186170//1,
KIDNE20188630//1, KIDNE20189960//1, LIVER20007750//8,
LIVER20010990//4, LIVER20030650//6, LIVER20038000//4,
MESAN20007110//1, MESAN20008150//3, MESAN20021220//2,
MESAN20060430//1, MESAN20067430//3, MESAN20084150//3,
NT2NE20018740//1, NT2NE20039210//1, NT2NE20053230//1,
NT2NE20059210//1, NT2NE20080770//1, NT2NE20082130//3,
NT2NE20092950//1, NT2NE20152620//1, NT2NE20167660//1,
NT2NE20181800//1, NT2RI20016240//2, NT2RI20021200//3,
NT2RI20033920//5, NT2RP70027790//2, NT2RP70031070//10,
NT2RP70031480//6, NT2RP70087140//1, OCBBF20000740//2,
OCBBF20012520//2, OCBBF20109780//1, OCBBF20110210//2,
OCBBF20110730//2, OCBBF20112280//3, OCBBF20118720//3,
OCBBF20123200//2, OCBBF20165910//9, OCBBF20176650//1,
OCBBF20185630//1, OCBBF20191950//3, PANCR10000860//1,
PLACE60004260//1, PLACE60006300//2, PLACE60053280//3,
PLACE60056910//1, PLACE60057860//3, PLACE60061370//1,
PLACE60070500//2, PLACE60104630//3, PLACE60107010//2,
PLACE60184870//1, PROST20011160//2, PROST20014150//2,
PROST20035830//1, PROST20050390//1, PROST20065100//7,
PROST20073280//1, PROST20082430//1, PROST20084680//3,
PROST20105450//6, PROST20110120//1, PROST20114100//2,
PROST20152510//4, PROST20168600//6, PUAEN10000870//2,
SKMUS20006790//1, SKMUS20020770//1, SKNMC20006350//1,
SKNSH20094350//2, SMINT20008110//3, SMINT20024140//1,
SMINT20026200//1, SMINT20028840//1, SMINT20045470//1,
SMINT20081330//2, SMINT20092160//1, SPLEN20015100//2,
SPLEN20017610//1, SPLEN20017810//2, SPLEN20024620//2,
SPLEN20054500//1, SPLEN20058180//1, SPLEN20085910//2,
SPLEN20090880//2, SPLEN20101950//5, SPLEN20104690//1,
SPLEN20105100//2, SPLEN20110180//1, SPLEN20121790//1,
SPLEN20125230//1, SPLEN20136700//1, SPLEN20175920//1,
SPLEN20177400//2, SPLEN20182850//1, SPLEN20183950//1,
SPLEN20190080//1, SPLEN20190770//1, SPLEN20193230//1,
SPLEN20193790//1, SPLEN20204670//1, TESOP10000350//1,
TESTI20006160//5, TESTI20038240//1, TESTI20043220//1,
TESTI20046540//1, TESTI20046870//1, TESTI20050400//1,
TESTI20051730//7, TESTI20053260//2, TESTI20053780//1,
TESTI20057200//1, TESTI20057590//1, TESTI20061200//10,
TESTI20062120//1, TESTI20063330//1, TESTI20063410//1,
TESTI20068530//2, TESTI20070400//10, TESTI20070740//1,
TESTI20073460//1, TESTI20095200//6, TESTI20095880//10,
TESTI20100090//1, TESTI20102390//2, TESTI20113940//3,
TESTI20121040//1, TESTI20149880//3, TESTI20151800//3,
TESTI20162780//4, TESTI20170170//1, TESTI20173050//1,
TESTI20186110//11, TESTI20198540//2, TESTI20199110//1,
TESTI20202830//1, TESTI20204260//1, TESTI20214630//2,
TESTI20244730//1, TESTI20245860//1, TESTI20246410//1,
TESTI20257910//1, TESTI20260640//1, TESTI20261040//4,
TESTI20262150//11, TESTI20262940//1, TESTI20264910//1,
TESTI20271790//9, TESTI20278280//3, TESTI20282420//2,
TESTI20282900//1, TESTI20286590//1, THYMU20007020//3,
THYMU20012020//1, THYMU20017270//2, THYMU20020800//4,
THYMU20025480//3, THYMU20030690//7, THYMU20034790//2,
THYMU20046350//1, THYMU20050010//5, THYMU20054800//2,
THYMU20055740//1, THYMU20062770//1, THYMU20078240//1,
THYMU20079690//2, THYMU20083390//3, THYMU20087270//1,
THYMU20100940//4, THYMU20106990//1, THYMU20115380//2,
THYMU20137050//3, THYMU20137570//1, THYMU20143230//2,
THYMU20145990//3, THYMU20150190//2, THYMU20153210//10,
THYMU20154790//3, THYMU20163600//2, THYMU20171580//1,
THYMU20176010//1, THYMU20178440//1, THYMU20185470//2,
TRACH20011540//2, TRACH20021380//4, TRACH20073990//1,
TRACH20081270//2, TRACH20149720//1, TRACH20149740//1,
TRACH20163470//11, TRACH20165330//3, TRACH20167090//2,
TRACH20173680//8, UMVEN10001380//2, UTERU20035770//1,
UTERU20045200//5, UTERU20064120//7, UTERU20086530//2,
UTERU20089300//1, UTERU20095100//3, UTERU20099040//5,
UTERU20103200//3, UTERU20125810//1, UTERU20127150//8,
UTERU20139760//1, UTERU20188840//2
[0561] The Names of clones whose deduced amino acid sequences were
detected to have functional domains with Pfam, and the name of hit
functional domains are as follows. The search result is indicated
as "clone name//functional domain name". When the clone has
multiple hit functional domains, they are listed and demarcated by
a double slash mark (//). When the clone has multiple hits of an
identical functional domain, each is listed without abridgment.
[0562] ADRGL20020290//Sodium:galactoside symporter
family//Nucleoside transporter [0563] ADRGL20021910//Immunoglobulin
domain [0564] ADRGL20026790//PWWP domain [0565]
ADRGL20036840//Class I Histocompatibility antigen, domains alpha 1
and 2 [0566] ADRGL20047770//ATP synthase (F/14-kDa) subunit [0567]
ADRGL20059610//O-Glycosyl hydrolase family 30 [0568]
ADRGL20062330//Spectrin repeat//Spectrin repeat//Bacterial
flagellin N-terminus//Spectrin repeat//Spectrin repeat//Spectrin
repeat [0569] ADRGL20066770//Collagen triple helix repeat (20
copies)//C1q domain [0570] ADRGL20079060//Transglutaminase-like
superfamily [0571] ASTRO20006530//Intermediate filament
proteins//Myc leucine zipper domain [0572]
ASTRO20010010//Photosynthetic reaction center protein [0573]
ASTRO20010290//PHD-finger [0574] ASTRO20026320//Viral (Superfamily
1) RNA helicase//Heavy-metal-associated domain//Viral (Superfamily
1) RNA helicase [0575] ASTRO20038400//Homeobox domain//Common
central domain of tyrosinase//Rhabdovirus nucleocapsid
protein//Homeobox domain//Homeobox domain//Homeobox domain [0576]
ASTRO20046280//MutT-like domain [0577] ASTRO20050810//FGGY family
of carbohydrate kinases//FGGY family of carbohydrate kinases [0578]
ASTRO20052420//RhoGEF domain//PH domain//SH3 domain [0579]
ASTRO20053430//FERM domain (Band 4.1 family)//FERM domain (Band 4.1
family)//Delta-aminolevulinic acid dehydratase//Lipoprotein amino
terminal region [0580] ASTRO20055570//Prion protein [0581]
ASTRO20055930//Aldehyde oxidase and xanthine dehydrogenase, C
terminus//Zinc finger, C3HC4 type (RING finger) [0582]
ASTRO20085080//WD domain, G-beta repeat//Fibrillarin//WD domain,
G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta
repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD
domain, G-beta repeat [0583] ASTRO20088950//Glycosyl hydrolase
family 1 [0584] BGGI120010750//Phosphoglucose isomerase//Ribosomal
protein L7Ae [0585] BNGH420015760//WD domain, G-beta repeat//WD
domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta
repeat//WD domain, G-beta repeat [0586] BNGH420024870//C2
domain//C2 domain//C2 domain [0587] BNGH420035290//Zinc finger,
C3HC4 type (RING finger)//TRAF-type zinc finger//Hr1 repeat
motif//WD domain, G-beta repeat//WD domain, G-beta repeat//WD
domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta
repeat//WD domain, G-beta repeat//WD domain, G-beta repeat [0588]
BNGH420036410//Arsenical pump membrane protein [0589]
BNGH420046790//Immunoglobulin domain [0590]
BNGH420052350//Urotensin II [0591] BNGH420059680//NHL repeat//NHL
repeat//NHL repeat//NHL repeat [0592] BNGH420070370//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type [0593] BNGH420074600//RNA
polymerase beta subunit [0594] BNGH420077980//Immunoglobulin
domain//Immunoglobulin domain//Immunoglobulin
domain//Immunoglobulin domain//Immunoglobulin
domain//Immunoglobulin domain [0595] BNGH420086030//PH
domain//RhoGAP domain [0596] BRACE20003310//KRAB box//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type [0597]
BRACE20007330//BTB/POZ domain//Kelch motif//Kelch motif//Kelch
motif//Kelch motif//Kelch motif//Kelch motif [0598]
BRACE20014450//alpha/beta hydrolase fold [0599]
BRACE20050870//DEAD/DEAH box helicase [0600] BRACE20051600//Reverse
transcriptase (RNA-dependent DNA polymerase) [0601]
BRACE20051930//MAM domain. [0602] BRACE20054600//von Willebrand
factor type D domain [0603] BRACE20055560//WD domain, G-beta
repeat//WD domain, G-beta repeat [0604]
BRACE20059810//TSC-22/dip/bun family [0605] BRACE20061620//SPRY
domain [0606] BRACE20065470//Ubiquitin family [0607]
BRACE20069000//CLN3 protein [0608] BRACE20079200//von Willebrand
factor type D domain [0609] BRACE20099070//FYVE zinc finger [0610]
BRACE20196180//HMG (high mobility group) box [0611]
BRACE20204670//Protein-tyrosine phosphatase//Dual specificity
phosphatase, catalytic domain//Fatty acid
desaturase//Protein-tyrosine phosphatase [0612]
BRACE20215410//Imidazoleglycerol-phosphate dehydratase//UvrD/REP
helicase [0613] BRAMY20001510//Zinc finger, C3HC4 type (RING
finger)//PHD-finger [0614] BRAMY20003540//PH domain//EF hand//EF
hand//Viral RNA dependent RNA
polymerase//Phosphatidylinositol-specific phospholipase C, X
domain//Phosphatidylinositol-specific phospholipase C, Y
domain//Bleomycin resistance protein//C2 domain [0615]
BRAMY20005080//Ubiquitin carboxyl-terminal hydrolase family 2
[0616] BRAMY20013670//S-adenosylmethionine synthetase [0617]
BRAMY20016780//Proprotein convertase P-domain [0618]
BRAMY20023640//UBX domain [0619] BRAMY20027990//C2 domain [0620]
BRAMY20028620//Quinolinate phosphoribosyl transferase [0621]
BRAMY20035380//Cation efflux family [0622] BRAMY20035830//BTB/POZ
domain//Thymidylate synthase [0623]
BRAMY20038980//Granulocyte-macrophage colony-stimulating
factor//Borrelia outer surface protein E and F [0624]
BRAMY20040580//Zinc finger, C2H2 type//Zinc finger, C2H2 type
[0625] BRAMY20043630//Leucine Rich Repeat//Leucine Rich
Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich
Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich
Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich
Repeat//Leucine Rich Repeat//Leucine Rich Repeat [0626]
BRAMY20044920//Ubiquitin carboxyl-terminal hydrolase family 2
[0627] BRAMY20045420//Domain found in Dishevelled, Egl-10, and
Pleckstrin [0628] BRAMY20051820//C2 domain [0629]
BRAMY20056620//Carboxyl transferase domain [0630]
BRAMY20056840//PWWP domain [0631] BRAMY20076100//Ligand-binding
domain of nuclear hormone receptor [0632] BRAMY20089770//ATP P2X
receptor [0633] BRAMY20091230//Mitochondrial carrier
proteins//Mitochondrial carrier proteins [0634]
BRAMY20094890//SURF4 family [0635] BRAMY20102900//Ephrin [0636]
BRAMY20111780//Zinc finger, C2H2 type//Transcription factor S-II
(TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//Zinc finger, C3HC4 type (RING
finger)//Zinc finger, C2H2 type//Zinc finger, C2H2 type [0637]
BRAMY20117670//DnaJ central domain (4 repeats)//DnaJ C terminal
region [0638] BRAMY20118410//Phospholipase D. Active site motif
[0639] BRAMY20118490//FGGY family of carbohydrate kinases [0640]
BRAMY20125360//Asparaginase [0641] BRAMY20134050//Nucleosome
assembly protein (NAP) [0642] BRAMY20143870//Peptidyl-tRNA
hydrolase [0643] BRAMY20152510//Protein-tyrosine phosphatase//Dual
specificity phosphatase, catalytic domain [0644] BRAMY20158550//EF
hand//EF hand [0645] BRAMY20206340//WD domain, G-beta
repeat//Dockerin domain type I//WD domain, G-beta repeat//WD
domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta
repeat [0646] BRAMY20227860//Insulin-like growth factor binding
proteins//Spectrin repeat [0647] BRAMY20234820//Ribosomal L25p
family [0648] BRAMY20238630//TPR Domain//TPR Domain//TPR Domain
[0649] BRAMY20244490//Adenylate kinase [0650] BRAMY20245140//Cyclic
nucleotide-binding domain [0651] BRAMY20251210//Ephrin receptor
ligand binding domain//EB module [0652] BRAMY20263000//WD domain,
G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta
repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD
domain, G-beta repeat [0653] BRAMY20274510//Ribosomal protein L11
[0654] BRAWH20014590//RNA recognition motif. (a.k.a. RRM, RBD, or
RNP domain) [0655] BRAWH20021910//Carboxylesterases [0656]
BRAWH20026010//Hepatitis C virus RNA dependent RNA polymerase
[0657] BRAWH20039640//Leucine rich repeat N-terminal
domain//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich
Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich
Repeat//Leucine rich repeat C-terminal domain//Leucine rich repeat
N-terminal domain//Leucine Rich Repeat//Leucine Rich
Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich
Repeat//Leucine Rich Repeat//Leucine rich repeat C-terminal domain
[0658] BRAWH20040680//Zinc finger, C3HC4 type (RING finger)//DENN
(AEX-3) domain [0659] BRAWH20047790//HMG (high mobility group) box
[0660] BRAWH20050740//BTB/POZ domain [0661] BRAWH20080580//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type//DnaJ central domain (4 repeats)//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Zinc finger, C2H2 type [0662] BRAWH20093040//Eukaryotic
protein kinase domain [0663] BRAWH20094900//BNR repeat//BNR
repeat//BNR repeat [0664] BRAWH20095900//KRAB box//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II
(TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//PHD-finger//Zinc finger,
C2H2 type//Zinc finger, C2H2 type [0665] BRAWH20183170//Leucine
Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich
Repeat [0666] BRAWH20185260//Troponin//Serine
hydroxymethyltransferase [0667] BRAWH20185270//Uncharacterized
protein family UPF0057 [0668] BRAWH20188750//Glypican//ubiE/COQ5
methyltransferase family [0669] BRAWH20191980//Proline
dehydrogenase [0670] BRCAN1001050//Cell division protein [0671]
BRCAN20005410//Zinc finger, C4 type (two domains)//Zinc finger,
C2HC type//SAM domain (Sterile alpha motif)//Sterile alpha motif
(SAM)/Pointed domain [0672] BRCOC20000470//TPR Domain//TPR Domain
[0673] BRSSN20005610//PDZ domain (Also known as DHR or GLGF).
[0674] BRSSN20005660//Bacterial type II secretion system protein
[0675] BRSSN20066440//SCAN domain//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type [0676]
BRSSN20074640//Peptidase family M48 [0677] BRSSN20093890//Kelch
motif//Kelch motif [0678] CD34C20001750//Immunoglobulin
domain//Immunoglobulin domain [0679] CTONG20004110//Ank repeat//Ank
repeat//Ank repeat//Ank repeat//Ank repeat//Tropomyosins//Transient
receptor//Apolipoprotein A1/A4/E family//MutS family, N-terminal
putative DNA binding domain//K-box region//Outer membrane efflux
protein [0680] CTONG20004520//SH3 domain [0681]
CTONG20007660//Caspase recruitment domain//DNA polymerase (viral)
N-terminal domain//bZIP transcription factor//K-box region [0682]
CTONG20008190//ADP-ribosylation factor family//Ras family [0683]
CTONG20017490//Sema domain//Sema domain//Integrins, beta
chain//Plexin repeat [0684] CTONG20020950//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
[0685] CTONG20029030//Leucine Rich Repeat//Leucine Rich
Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich
Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich
Repeat [0686] CTONG20030280//WD domain, G-beta
repeat//Gram-negative pili assembly chaperone//WD domain, G-beta
repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD
domain, G-beta repeat//WD domain, G-beta repeat [0687]
CTONG20032930//Armadillo/beta-catenin-like repeats [0688]
CTONG20033610//RyR domain [0689] CTONG20033750//FtsK/SpoIIIE
family//ATPases associated with various cellular activities (AAA)
[0690] CTONG20036990//Immunoglobulin domain//Immunoglobulin domain
[0691] CTONG20044230//Zinc finger, C2H2 type//Zinc finger, C2H2
type [0692] CTONG20044870//PH domain//PH domain [0693]
CTONG20045500//Translation initiation factor IF-3//HCO3-transporter
family//HCO3-transporter family//Domain of unknown function DUF139
[0694] CTONG20046690//Src homology domain 2 [0695]
CTONG20049480//bZIP transcription factor//Carbamoyl-phosphate
synthase (CPSase)//tRNA synthetases class I (C) [0696]
CTONG20060040//NusB family [0697] CTONG20063770//KE2 family
protein//Spectrin repeat [0698] CTONG20063930//SH3 domain//WW
domain//WW domain//PH domain//RhoGAP domain [0699]
CTONG20066110//TPR Domain//TPR Domain [0700]
CTONG20068360//Mitochondrial carrier proteins//Mitochondrial
carrier proteins [0701] CTONG20069420//Ribosomal protein S14p/S29e
[0702] CTONG20070090//Bacterial luciferase [0703] CTONG20070720//PH
domain//RhoGAP domain//bZIP transcription factor [0704]
CTONG20070910//PCI domain [0705] CTONG20071040//Beta/Gamma
crystallin//Beta/Gamma crystallin//Beta/Gamma
crystallin//Beta/Gamma crystallin//Similarity to lectin domain of
ricin beta-chain, 3 copies. [0706] CTONG20071680//3'-5'
exonuclease//Cytochrome c oxidase subunit III//Ammonium Transporter
Family//7 transmembrane receptor (Secretin family) [0707]
CTONG20072930//KRAB box//Ribosomal protein L20//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II
(TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//Putative zinc finger in
N-recognin//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
[0708] CTONG20074000//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type [0709] CTONG20074170//DENN (AEX-3) domain [0710]
CTONG20076810//Ribosomal protein L16//Pheromone A receptor [0711]
CTONG20079590//Sialyltransferase family [0712]
CTONG20083430//Nuclear transition protein 2 [0713]
CTONG20083980//WH1 domain [0714] CTONG20084660//SCAN domain [0715]
CTONG20085210//Lipase (class 3) [0716] CTONG20165750//G-patch
domain//Double-stranded RNA binding motif [0717]
CTONG20169040//bZIP transcription factor//Adenylate
cyclase//Intermediate filament proteins [0718] CTONG20170940//Ank
repeat//Ank repeat//Ank repeat//SAM domain (Sterile alpha
motif)
[0719] CTONG20174580//TBC domain [0720]
CTONG20176040//ADP-ribosylation factor family//Ras family [0721]
CTONG20180690//Collagen triple helix repeat (20 copies) [0722]
CTONG20183430//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank
repeat//Ank repeat//Ank repeat//Ank repeat//Zinc finger, C3HC4 type
(RING finger)//Zinc finger, C3HC4 type (RING finger)//Zinc finger,
C3HC4 type (RING finger) [0723] CTONG20184830//ABC transporter
[0724] CTONG20186290//Aldehyde dehydrogenase family [0725]
CTONG20186370//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type [0726]
CTONG20186520//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription
factor S-II (TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type [0727] CTONG20186550//BTB/POZ domain//K+ channel
tetramerisation domain [0728] CTONG20188080//TPR Domain [0729]
CTONG20189000//RhoGEF domain [0730] CTONG20190290//R3H domain//RNA
dependent RNA polymerase//Uncharacterized protein family UPF0024
[0731] DFNES20025500//Sigma-54 interaction domain//ATPases
associated with various cellular activities (AAA) [0732]
DFNES20043710//Src homology domain 2//Domain of unknown function
DUF36 [0733] DFNES20055400//Viral coat protein//Putative
diphthamide synthesis protein//Influenza non-structural protein
(NS1) [0734] DFNES20057660//Plant thionins//Mitochondrial carrier
proteins//Mitochondrial carrier proteins [0735]
DFNES20072990//Integral membrane protein DUF6//Integral membrane
protein DUF6 [0736] DFNES20073320//Zinc finger, C3HC4 type (RING
finger)//PHD-finger//B-box zinc finger. [0737] DFNES20076340//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
[0738] DFNES20080880//Glycosyl transferases//Similarity to lectin
domain of ricin beta-chain, 3 copies. [0739]
DFNES20094820//PHD-finger//Zn-finger in ubiquitin-hydrolases and
other proteins [0740] FCBBF10000230//Sec7 domain//PH domain [0741]
FCBBF10004760//HMG (high mobility group) box [0742]
FCBBF20018680//C2 domain//C2 domain [0743] FCBBF20020440//Urease
[0744] FCBBF20023490//Helicases conserved C-terminal domain [0745]
FCBBF20033360//BTB/POZ domain//Kelch motif//Kelch motif//Kelch
motif//Kelch motif//Kelch motif [0746] FCBBF20035430//AN1-like Zinc
finger//AN1-like Zinc finger [0747] FCBBF20035490//KH domain [0748]
FCBBF20041380//SAM domain (Sterile alpha motif) [0749]
FCBBF20043730//UBA domain [0750] FCBBF20059660//TPR Domain [0751]
FCBBF20066340//PH domain [0752] FCBBF20070950//DNA binding domain
with preference for A/T rich regions [0753] FCBBF30001100//DENN
(AEX-3) domain//PPR repeat [0754] FCBBF30002270//linker histone H1
and H5 family [0755] FCBBF30003610//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Plant PEC family
metallothionein//DM DNA binding domain//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//PHD-finger//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Phorbol esters/diacylglycerol binding domain (C1 domain)
[0756] FCBBF30004340//Ribosomal protein S3, C-terminal
domain.//Similarity to lectin domain of ricin beta-chain, 3 copies.
[0757] FCBBF30005360//Sigma-54 interaction domain//ATPases
associated with various cellular activities (AAA)//ATPases
associated with various cellular activities (AAA) [0758]
FCBBF30005500//PH domain//PH domain//Putative GTP-ase activating
protein for Arf [0759] FCBBF30019140//`chromo` (CHRromatin
Organization MOdifier) domain//`chromo` (CHRromatin Organization
MOdifier) domain//DEAD/DEAH box helicase//SNF2 and others
N-terminal domain//Helicases conserved C-terminal domain [0760]
FCBBF30019180//Armadillo/beta-catenin-like repeats//Lipoprotein
amino terminal region [0761] FCBBF30021900//Zinc finger, C2H2
type//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//BolA-like protein//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Snake toxin//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type [0762] FCBBF30022680//3'-5' exonuclease [0763]
FCBBF30029250//SET domain [0764] FCBBF30035570//C2 domain [0765]
FCBBF30048420//T-box//wnt family of developmental signaling
proteins [0766] FCBBF30071500//Influenza RNA-dependent RNA
polymerase subunit PB1//Reprolysin family propeptide//Leptin [0767]
FCBBF30076310//Eukaryotic protein kinase domain//Eukaryotic protein
kinase domain//Protein kinase C terminal domain [0768]
FCBBF30079770//D-isomer specific 2-hydroxyacid dehydrogenases
[0769] FCBBF30080730//RNA recognition motif. (a.k.a. RRM, RBD, or
RNP domain)//Zinc knuckle [0770] FCBBF30085560//Pyridine
nucleotide-disulphide oxidoreductase//FAD binding domain//Flavin
containing amine oxidase//Phytoene dehydrogenase related enzyme
[0771] FCBBF30093170//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type [0772] FCBBF30100080//Sec7 domain [0773]
FCBBF30100120//PDZ domain (Also known as DHR or GLGF). [0774]
FCBBF30100410//Nucleosome assembly protein (NAP) [0775]
FCBBF30118670//Reprolysin (M12B) family zinc
metalloprotease//Disintegrin//EB module//Hantavirus glycoprotein
G2//Adenovirus E3 region protein CR2//jmjN domain [0776]
FCBBF30125460//Zinc finger, C3HC4 type (RING finger) [0777]
FCBBF30129010//KRAB box//Zinc finger, C2H2 type//GATA zinc
finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor
S-II (TFIIS)//Zinc finger, C2H2 type [0778]
FCBBF30130410//UvrB/uvrC motif [0779]
FCBBF30132050//Galactosyltransferase//Fringe-like [0780]
FCBBF30132660//Leucine rich repeat N-terminal domain//Leucine Rich
Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich
Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich
Repeat [0781] FCBBF30136230//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Cystatin
domain//Homeobox domain//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type [0782] FCBBF30142290//PHD-finger
[0783] FCBBF30143550//Phosphatidylinositol-4-phosphate 5-Kinase
[0784]
FCBBF30153170//Phosphofructokinase//Phosphofructokinase//Phosphofructokin-
ase//Phosphofructokinase [0785] FCBBF30161780//gag gene protein p24
(core nucleocapsid protein)//Zinc knuckle FCBBF30164510//Cadherin
domain//Cadherin domain//Cadherin domain//Fructose-bisphosphate
aldolase class-I//Cadherin domain//Cadherin
domain//Alphaherpesvirus glycoprotein E//Cadherin cytoplasmic
region [0786] FCBBF30166220//Serine hydroxymethyltransferase [0787]
FCBBF30169280//PHD-finger//Zinc finger, C3HC4 type (RING finger)
[0788] FCBBF30171230//Subtilase family//Proprotein convertase
P-domain [0789] FCBBF30173960//Beta-lactamase//TPR Domain [0790]
FCBBF30194550//Arsenical pump membrane protein//Ank repeat//Ank
repeat//Ank repeat//Ank repeat//Ank repeat//Dehydrogenase E1
component//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank
repeat//Ank repeat//Ank repeat [0791] FCBBF30195690//C2 domain
[0792] FCBBF30197840//Sushi domain (SCR repeat)//CUB domain//Sushi
domain (SCR repeat)//CUB domain//Sushi domain (SCR repeat)//Sushi
domain (SCR repeat)//Sushi domain (SCR repeat) [0793]
FCBBF30212210//Immunoglobulin domain [0794] FCBBF30215240//PH
domain//FERM domain (Band 4.1 family) [0795]
FCBBF30220050//Ligand-binding domain of nuclear hormone receptor
[0796] FCBBF30222910//Corticotropin-releasing factor family [0797]
FCBBF30236670//DEAD/DEAH box helicase [0798] FCBBF30250980//WD
domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta
repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD
domain, G-beta repeat [0799] FCBBF30255680//Vesicular monoamine
transporter//GGL domain//Ezrin/radixin/moesin family//Ank
repeat//Ank repeat [0800] FCBBF30257370//Geminivirus AL1
protein//Outer membrane efflux protein [0801] FCBBF30259050//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger present in dystrophin, CBP/p300//Zinc finger,
C2H2 type//PHD-finger//Zinc finger, C2H2 type//Zinc finger, C2H2
type//DM DNA binding domain//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2
type//TRAF-type zinc finger//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type [0802] FCBBF30260210//SNF2 and others N-terminal
domain//Helicases conserved C-terminal domain//Domain of unknown
function DUF94 [0803] FCBBF30263080//Zinc finger, C2H2 type//Zinc
finger, C2H2 type [0804] FCBBF30266510//Domain of unknown function
DUF71 [0805] FCBBF30271990//Ank repeat//Ank repeat//Ank repeat//Ank
repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank
repeat//Ank repeat//Ank repeat//Ank repeat [0806]
FCBBF30275590//LIM domain containing proteins [0807]
FCBBF30282020//Ank repeat//Ank repeat//Ank repeat//K+ channel
tetramerisation domain//BTB/POZ domain [0808] FCBBF30285930//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type [0809]
FCBBF50001650//MORN motif//MORN motif//MORN motif//MORN motif//MORN
motif//MORN motif//MORN motif//MORN motif [0810]
FCBBF50003530//Zinc finger, C3HC4 type (RING finger) [0811]
FCBBF50004950//Putative replicase 1 (ORF2) [0812]
FEBRA20005040//Intermediate filament proteins//Hr1 repeat
motif//Troponin//GrpE [0813] FEBRA20007820//DNA polymerase family B
[0814] FEBRA20018670//Viral methyltransferase//Ribosomal protein
S19//Alpha-2-macroglobulin family N-terminal region [0815]
FEBRA20026820//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Putative zinc finger in N-recognin//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type [0816]
FEBRA20027070//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//TRAF-type zinc
finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type [0817] FEBRA20029620//Leucine Rich
Repeat//Leucine Rich Repeat//Leucine Rich Repeat [0818]
FEBRA20031000//Leucine Rich Repeat//Leucine Rich Repeat//Leucine
Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich
Repeat//Insulin/IGF/Relaxin family//Ribosomal RNA adenine
dimethylases//SAM domain (Sterile alpha motif)//TFIIE alpha
subunit//Zinc finger, C3HC4 type (RING finger) [0819]
FEBRA20031280//Protein of unknown function DUF82 [0820]
FEBRA20038330//Corticotropin-releasing factor family [0821]
FEBRA20038970//Laminin EGF-like (Domains III and V)//Phorbol
esters/diacylglycerol binding domain (C1 domain)//EGF-like
domain//EGF-like domain//Trypsin Inhibitor like cysteine rich
domain//Metallothionein//EGF-like domain//EGF-like
domain//Extracellular link domain [0822] FEBRA20046200//Ank
repeat//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank
repeat//Ank repeat [0823] FEBRA20046510//Zinc finger, C2H2
type//Zinc finger, C2H2 type//BolA-like protein//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type [0824] FEBRA20063720//KRAB box//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type [0825]
FEBRA20078800//NADH ubiquinone oxidoreductase, 20 Kd subunit [0826]
FEBRA20080860//Hantavirus glycoprotein G2 [0827] FEBRA20087550//WD
domain, G-beta repeat//WD domain, G-beta repeat [0828]
FEBRA20088610//CRAL/TR10 domain. [0829] FEBRA20088810//Fibroblast
growth factor [0830] FEBRA20090160//Nuclear transition protein 2
[0831] FEBRA20090220//Nucleotidyl transferase//Bacterial
transferase hexapeptide (four repeats)//Bacterial transferase
hexapeptide (four repeats)//Bacterial transferase hexapeptide (four
repeats)//Domain of unknown function DUF29//Peptide
hormone//eIF4-gamma/eIF5/eIF2-epsilon [0832] FEBRA20092760//LIM
domain containing proteins//LIM domain containing proteins//LIM
domain containing proteins [0833] FEBRA20115930//Divalent cation
transporter//Translation initiation factor IF-3//Divalent cation
transporter [0834] FEBRA20150420//Transient receptor//Borrelia
ORF-A//Transient receptor FEBRA20170240//SCAN domain//KRAB
box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type [0835]
FEBRA20172230//Phospholipase D. Active site motif//Phospholipase D.
Active site motif [0836] FEBRA20173330//Eukaryotic protein kinase
domain [0837] FEBRA20175330//D-isomer specific 2-hydroxyacid
dehydrogenases [0838] FEBRA20191720//GGL domain//Regulator of G
protein signaling domain [0839] HCHON10000150//LIM domain
containing proteins//LIM domain containing proteins//LIM domain
containing proteins//Zinc finger, C3HC4 type (RING finger) [0840]
HCHON20000870//Eukaryotic protein kinase domain [0841]
HCHON20002650//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type [0842] HCHON20002710//Ubiquitin carboxyl-terminal
hydrolase family 2 [0843] HCHON20015050//von Willebrand factor type
A domain//IPT/TIG domain//Sm protein [0844] HEART10001420//MYND
finger//SET domain [0845] HEART10001490//FAD binding domain [0846]
HEART20009590//Peptidase family M41 [0847] HEART20019310//Zinc
finger, C3HC4 type (RING finger)//PHD-finger//B-box zinc finger.
[0848] HEART20022200//Influenza Matrix protein
(M1)//metallopeptidase family M24 [0849] HEART20047640//3'
5'-cyclic nucleotide phosphodiesterase//Formin Homology 2 Domain
[0850] HEART20082570//C-5 cytosine-specific DNA methylase//Glycine
cleavage T-protein (aminomethyl transferase) [0851]
HHDPC20081230//RNA recognition motif. (a.k.a. RRM, RBD, or RNP
domain)//RNA recognition motif. (a.k.a. RRM, RBD, or RNP
domain)//RNA recognition motif. (a.k.a. RRM, RBD, or RNP
domain)//RNA recognition motif. (a.k.a. RRM, RBD, or RNP
domain)
[0852] HHDPC20088160//PDZ domain (Also known as DHR or GLGF).
[0853] HLUNG20008460//bZIP transcription factor [0854]
HLUNG20011260//Eukaryotic protein kinase domain [0855]
HLUNG20011460//RNA recognition motif. (a.k.a. RRM, RBD, or RNP
domain)//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
[0856] HLUNG20014590//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Putative zinc finger in N-recognin//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Transcription factor S-II (TFIIS)//Zinc finger,
C2H2 type//Zinc finger, C2H2 type [0857] HLUNG20015070//Leucine
rich repeat N-terminal domain//Leucine Rich Repeat//Leucine Rich
Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich
Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine rich
repeat C-terminal domain//Immunoglobulin domain [0858]
HLUNG20024050//Rubredoxin [0859] HLUNG20028110//Zinc finger, C3HC4
type (RING finger)//TPR Domain//TPR Domain//TPR Domain//Zinc
finger, C3HC4 type (RING finger)//Aldo/keto reductase family [0860]
HLUNG20030420//Ank repeat//Ank repeat//Ank repeat//Ank repeat//Ank
repeat [0861] HLUNG20032460//Prolyl oligopeptidase
family//Lipoate-protein ligase B//alpha/beta hydrolase fold [0862]
HLUNG20033060//HMG (high mobility group) box [0863]
HLUNG20041590//TPR Domain//TPR Domain//Domain of unknown function
DUF27 [0864] HLUNG20042730//Cytochrome P450 [0865]
HLUNG20051330//FHIPEP family [0866] HLUNG20063700//Progesterone
receptor [0867] HLUNG20065990//bZIP transcription factor//SNAP-25
family//Syntaxin [0868] HLUNG20068120//Fimbrial Usher proteins
[0869] HLUNG20069350//EF hand//EF hand//EF hand [0870]
HLUNG20070410//Dihydropyridine sensitive L-type calcium channel
(Beta subunit) [0871] HLUNG20081390//DnaJ domain [0872]
HLUNG20082350//PH domain//START domain [0873] HLUNG20083330//DNA
polymerase III beta subunit//Fibrillar collagen C-terminal domain
[0874] HLUNG20084790//WD domain, G-beta repeat//WD domain, G-beta
repeat//WD domain, G-beta repeat [0875] HLUNG20085210//C2 domain
[0876] KIDNE20016360//PAS domain//PAC motif//Ion transport
protein//Transmembrane region cyclic Nucleotide Gated
Channel//Cyclic nucleotide-binding domain [0877] KIDNE20027980//SAM
domain (Sterile alpha motif) [0878] KIDNE20080690//Glycosyl
hydrolases family 18//Aminotransferases class-III
pyridoxal-phosphate//Methyl-accepting chemotaxis protein (MCP)
signaling domain//Aminotransferases class-III pyridoxal-phosphate
[0879] KIDNE20081170//Kinesin motor domain//Kinesin motor domain
[0880] KIDNE20083620//Asparaginase [0881] KIDNE20084030//Sugar (and
other) transporter [0882] KIDNE20084730//Neuraxin and MAP1B
proteins//Formin Homology 2 Domain [0883] KIDNE20086490//gag gene
protein p24 (core nucleocapsid protein) [0884]
KIDNE20087880//Reverse transcriptase (RNA-dependent DNA polymerase)
[0885] KIDNE20088240//EF hand//EF hand//EF hand [0886]
KIDNE20089870//WD domain, G-beta repeat//WD domain, G-beta
repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD
domain, G-beta repeat//WD domain, G-beta repeat [0887]
KIDNE20094670//Sigma-54 interaction domain//FtsK/SpoIIIE
family//ATPases associated with various cellular activities (AAA)
[0888] KIDNE20133880//G-protein alpha subunit [0889]
KIDNE20141700//Ribosomal family S4e [0890] KIDNE20142900//EGF-like
domain//EB module//EGF-like domain//EGF-like domain [0891]
KIDNE20148080//Zinc finger, C3HC4 type (RING finger) [0892]
KIDNE20149780//Ank repeat//Ank repeat//Ank repeat [0893]
KIDNE20152440//Trypsin//PDZ domain (Also known as DHR or GLGF).
[0894] KIDNE20154330//PDZ domain (Also known as DHR or GLGF).//PDZ
domain (Also known as DHR or GLGF).//PDZ domain (Also known as DHR
or GLGF).//PDZ domain (Also known as DHR or GLGF).//PDZ domain
(Also known as DHR or GLGF).//PDZ domain (Also known as DHR or
GLGF). [0895] KIDNE20160360//Sec7 domain//PH domain [0896]
KIDNE20169180//EGF-like domain//EB module//EGF-like domain//Trypsin
Inhibitor like cysteine rich domain//EGF-like domain//TNFR/NGFR
cysteine-rich region//Zona pellucida-like domain [0897]
KIDNE20170400//Leucine Rich Repeat//Leucine Rich Repeat//Leucine
Rich Repeat//Protein kinase C terminal domain//Rubredoxin [0898]
KIDNE20173150//Acetyltransferase (GNAT) family [0899]
KIDNE20173430//PDZ domain (Also known as DHR or GLGF).//PDZ domain
(Also known as DHR or GLGF). [0900] KIDNE20186170//UDP-glucoronosyl
and UDP-glucosyl transferases [0901] KIDNE20189960//Trehalase
[0902] LIVER20006260//KRAB box//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Plant PEC
family metallothionein//Zinc finger, C2H2 type//Zinc finger, C2H2
type [0903] LIVER20007750//Sugar (and other) transporter [0904]
LIVER20010760//Lectin C-type domain [0905] LIVER20010990//DNA
gyrase/topoisomerase IV, subunit A [0906] LIVER20013890//tRNA
synthetases class I (C) [0907] LIVER20026440//Cytochrome P450
[0908] LIVER20030650//General diffusion Gram-negative porins [0909]
LIVER20038000//Mitochondrial carrier proteins//Mitochondrial
carrier proteins//Mitochondrial carrier proteins [0910]
LIVER20040740//CRAL/TR10 domain. [0911] LIVER20055270//AIR synthase
related protein [0912] MESAN20006200//Annexin//Annexin [0913]
MESAN20008150//IBR domain [0914] MESAN20009090//CUB domain [0915]
MESAN20016270//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type [0916] MESAN20021130//SH3
domain//Eukaryotic protein kinase domain [0917]
MESAN20021220//Leucine Rich Repeat//Leucine Rich Repeat//Leucine
Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich
Repeat//Leucine rich repeat C-terminal domain//Leucine rich repeat
N-terminal domain//Leucine Rich Repeat//Leucine Rich
Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich
Repeat//Leucine rich repeat C-terminal domain [0918]
MESAN20026870//PAN domain//TBC domain [0919] MESAN20027240//RhoGEF
domain [0920] MESAN20027900//von Willebrand factor type A
domain//von Willebrand factor type A domain//von Willebrand factor
type A domain//Protozoan/cyanobacterial globin//von Willebrand
factor type A domain//von Willebrand factor type A domain [0921]
MESAN20030350//LGN motif, putative GEF specific for G-alpha
GTPase//DNA gyrase/topoisomerase IV, subunit A [0922]
MESAN20030370//Porphobilinogen deaminase//GHMP kinases putative
ATP-binding proteins//Protein of unknown function DUF113 [0923]
MESAN20034440//Viral DNA-binding protein//Uncharacterized protein
family UPF0024 [0924] MESAN20038520//Caspase recruitment
domain//RNA polymerase beta subunit [0925]
MESAN20057240//Elongation factor TS//Helix-hairpin-helix motif.
[0926] MESAN20058110//FKBP-type peptidyl-prolyl cis-trans
isomerases//Elongation factor Tu family//FKBP-type peptidyl-prolyl
cis-trans isomerases//FKBP-type peptidyl-prolyl cis-trans
isomerases [0927] MESAN20059570//EGF-like domain//SEA
domain//Immunoglobulin domain [0928] MESAN20060430//SET domain
[0929] MESAN20067430//Tropomyosins [0930] MESAN20069530//Calponin
homology (CH) domain//PDZ domain (Also known as DHR or GLGF).
[0931] MESAN20090190//EGF-like domain//EGF-like domain//EGF-like
domain//EGF-like domain//EGF-like domain//EGF-like
domain//Metallothionein//CUB domain [0932] MESAN20095220//Adaptin N
terminal region [0933] MESAN20095800//Cyclophilin type
peptidyl-prolyl cis-trans isomerase//RNA recognition motif. (a.k.a.
RRM, RBD, or RNP domain) [0934] NT2NE20018890//WD domain, G-beta
repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD
domain, G-beta repeat [0935] NT2NE20026200//Transketolase [0936]
NT2NE20026510//Zinc finger, C3HC4 type (RING finger) [0937]
NT2NE20038870//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Lipoprotein
[0938] NT2NE20042550//Viral (Superfamily 1) RNA helicase//NB-ARC
domain//Adenylate kinase//Adenylate kinase [0939]
NT2NE20053950//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type [0940]
NT2NE20060750//KRAB box//Zinc finger, C2H2 type [0941]
NT2NE20061030//SCAN domain [0942] NT2NE20077270//Adenovirus EB1 55K
protein/large t-antigen [0943] NT2NE20079670//KRAB box//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Transcription factor S-II
(TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type [0944] NT2NE20087270//Tudor domain [0945]
NT2NE20092950//Fibronectin type III domain [0946]
NT2NE20108420//Domain of unknown function DUF130//Oxysterol-binding
protein [0947] NT2NE20117580//NADH ubiquinone oxidoreductase, 20 Kd
subunit [0948] NT2NE20127900//Myo-inositol-1-phosphate synthase
[0949] NT2NE20140130//Sema domain [0950] NT2NE20145250//Stathmin
family [0951] NT2NE20153620//FERM domain (Band 4.1 family)//PH
domain [0952] NT2RI20093010//Tetrahydrofolate
dehydrogenase/cyclohydrolase [0953] NT2RP70001120//Ank repeat//Ank
repeat//Ank repeat//Insulinase (Peptidase family M16) [0954]
NT2RP70001730//BTB/POZ domain//Kelch motif//Kelch motif//Kelch
motif//Kelch motif//Kelch motif [0955] NT2RP70003110//Collagen
triple helix repeat (20 copies)//Heavy-metal-associated domain
[0956] NT2RP70027790//Leucine Rich Repeat//Leucine Rich
Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich
Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich
Repeat//Leucine Rich Repeat//Leucine Rich Repeat [0957]
NT2RP70029780//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2
type//PHD-finger//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Transcription factor S-II (TFIIS) [0958]
NT2RP70030840//Viral (Superfamily 1) RNA helicase [0959]
NT2RP70031070//Nucleoside transporter [0960]
NT2RP70031340//PHD-finger [0961] NT2RP70046410//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type [0962]
NT2RP70056690//Thrombospondin type 1 domain//Domain of unknown
function DUF18//Thrombospondin type 1 domain//Thrombospondin type 1
domain//Thrombospondin type 1 domain//Thrombospondin type 1
domain//Keratin, high sulfur B2 protein [0963] NT2RP70057500//KRAB
box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2
type//DnaJ central domain (4 repeats)//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type [0964] NT2RP70064570//Calpain family cysteine
protease//Calpain large subunit, domain III//EF hand//EF hand
[0965] NT2RP70075300//KRAB box//Domain of unknown function
DUF19//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type [0966]
NT2RP70075800//recA bacterial DNA recombination proteins//WD
domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta
repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD
domain, G-beta repeat//SH3 domain [0967] NT2RP70090870//KRAB
box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//DM DNA binding domain//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Transcription
factor S-II (TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type [0968]
NTONG20005310//Ribosomal protein S9/S16 [0969] NTONG20029850//EF
hand//EF hand//EF hand [0970] NTONG20031580//Hsp20/alpha crystallin
family [0971] NTONG20032100//Intermediate filament proteins [0972]
NTONG20034540//GAF domain//GAF domain//3' 5'-cyclic nucleotide
phosphodiesterase [0973] NTONG20035150//BTB/POZ domain//Kelch
motif//Kelch motif//Kelch motif//Kelch motif//Kelch motif [0974]
NTONG20043080//Immunoglobulin domain//Immunoglobulin
domain//Immunoglobulin domain [0975] NTONG20048440//PH
domain//K-box region [0976] NTONG20053630//DNA binding domain with
preference for A/T rich regions//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Progesterone receptor//Zinc finger, C2H2 type [0977]
NTONG20053730//Ribosomal protein S2//Ubiquitin carboxyl-terminal
hydrolases family 2//Ubiquitin carboxyl-terminal hydrolase family 2
[0978] NTONG20053910//Translin family//PH domain//Putative GTP-ase
activating protein for Arf//Ank repeat//Ank repeat [0979]
NTONG20055200//Calcium channel extracellular region//Elongation
factor Tu family//Elongation factor G C-terminus [0980]
NTONG20058010//AMP-binding enzyme [0981] OCBBF20000740//Leucine
rich repeat N-terminal domain//Leucine Rich Repeat//Leucine Rich
Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich
Repeat//Leucine rich repeat C-terminal domain//Immunoglobulin
domain [0982] OCBBF20011860//LIM domain containing proteins [0983]
OCBBF20012520//Leucine rich repeat N-terminal domain//Leucine Rich
Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich
Repeat//Leucine Rich Repeat//Leucine rich repeat C-terminal
domain//Immunoglobulin domain [0984] OCBBF20016390//Chitin
synthase//Fibronectin type II domain [0985] OCBBF20016810//`Paired
box` domain [0986] OCBBF20110210//Immunoglobulin
domain//Immunoglobulin domain//Immunoglobulin domain [0987]
OCBBF20113110//AP endonuclease family 1 [0988] OCBBF20116250//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2
type//PHD-finger//Zinc finger, C2H2 type [0989]
OCBBF20120010//Thrombospondin type 1 domain [0990]
OCBBF20120950//K+ channel tetramerisation domain//BTB/POZ
domain//Zinc finger, C2H2 type//Zinc finger, C2H2 type [0991]
OCBBF20121910//Ribosomal protein L24e [0992] OCBBF20147070//DNA
polymerase (viral) C-terminal domain [0993] OCBBF20156450//KRAB
box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
[0994] OCBBF20157970//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//TRAF-type zinc finger//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//DM DNA binding
domain//Zinc finger, C2H2 type [0995] OCBBF20165910//DnaB-like
helicase [0996] OCBBF20166890//CAP-Gly domain//CAP-Gly domain
[0997] OCBBF20166900//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Transcription factor S-II
(TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type [0998]
OCBBF20167290//haloacid dehalogenase-like
hydrolase//Thioredoxin//Aminoglycoside phosphotransferase//Acyl-CoA
dehydrogenase [0999] OCBBF20174580//Cyclin [1000]
OCBBF20174890//Death domain [1001] OCBBF20175360//Zinc finger, C2H2
type [1002] OCBBF20177540//KRAB box//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Src homology domain
2//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type [1003] OCBBF20177910//Corticotropin-releasing factor
family [1004] OCBBF20182060//Inward rectifier potassium channel
[1005] OCBBF20191950//EGF-like domain//Low-density lipoprotein
receptor domain class A//Low-density lipoprotein receptor domain
class A//EGF-like domain//Low-density lipoprotein receptor domain
class A//EGF-like domain//Low-density lipoprotein receptor domain
class A//Low-density lipoprotein receptor domain class A//EGF-like
domain//EGF-like domain//Low-density lipoprotein receptor repeat
class B//Low-density lipoprotein receptor repeat class
B//Low-density lipoprotein receptor repeat class B//Low-density
lipoprotein receptor repeat class B//Low-density lipoprotein
receptor repeat class B//EGF-like domain//60 Kd inner membrane
protein [1006] PANCR10000860//Trypsin//Trypsin [1007]
PEBLM10001470//Zinc finger, C2H2 type//Fork head domain [1008]
PEBLM20001800//Immunoglobulin domain//Immunoglobulin
domain//Immunoglobulin domain//Immunoglobulin
domain//Immunoglobulin domain [1009] PEBLM20003260//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II
(TFIIS)//Src homology domain 2//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Src homology domain 2//Zinc finger, C2H2 type
[1010] PEBLM20005020//Virion host shutoff protein [1011]
PLACE50001390//PHD-finger [1012] PLACE60004260//Cystatin domain
[1013] PLACE60006300//Immunoglobulin domain [1014]
PLACE60012620//WD domain, G-beta repeat//WD domain, G-beta
repeat//WD domain, G-beta repeat//WD domain, G-beta
repeat//AN1-like Zinc finger//FYVE zinc finger [1015]
PLACE60054230//CheR methyltransferase//Formin Homology 2 Domain
[1016] PLACE60054820//Regulator of chromosome condensation
(RCC1)//Regulator of chromosome condensation (RCC1)//Regulator of
chromosome condensation (RCC1)//Regulator of chromosome
condensation (RCC1) [1017] PLACE60054870//IQ calmodulin-binding
motif//IQ calmodulin-binding motif [1018] PLACE60055590//Zinc
finger, C3HC4 type (RING finger) [1019]
PLACE60061370//Phosphotyrosine interaction domain
(PTB/PID).//Extracellular link domain [1020]
PLACE60062660//Gamma-adaptin, C-terminus [1021]
PLACE60064180//Lumenal portion of Cytochrome b559, alpha (gene
psbE) subunit.//Viral (Superfamily 1) RNA helicase [1022]
PLACE60066970//SCAN domain//Zinc finger, C2H2
type//PHD-finger//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type [1023] PLACE60070500//Immunoglobulin
domain//Immunoglobulin domain [1024]
PLACE60073090//Myo-inositol-1-phosphate synthase [1025]
PLACE60074820//Adenylate kinase [1026]
PLACE60082850//Pathogenesis-related protein Bet v I family [1027]
PLACE60087680//Thyroglobulin type-1 repeat [1028]
PLACE60093380//Penicillin amidase//Bacterial regulatory proteins,
lacI family//Vacuolar sorting protein 9 (VPS9) domain [1029]
PLACE60095600//DEAD/DEAH box helicase [1030] PLACE60098350//MAGE
family [1031] PLACE60104630//Photosystem I reaction centre subunit
VIII [1032] PLACE60113340//EGF-like domain//Laminin G
domain//Insulin-like growth factor binding proteins//EGF-like
domain//Laminin G domain [1033] PLACE60118810//bZIP transcription
factor//TPR Domain//TPR Domain//TPR Domain//TPR Domain//PPR repeat
[1034] PLACE60119700//EF hand [1035] PLACE60122970//Zinc finger,
C2H2 type [1036] PLACE60138840//Syndecan domain//Mitochondrial
carrier proteins//Mitochondrial carrier proteins//Mitochondrial
carrier proteins [1037]
PLACE60140640//Phosphoribulokinase//Shikimate
kinase//Uncharacterized protein family UPF0038 [1038]
PLACE60154450//RhoGAP domain [1039] PLACE60177880//Immunoglobulin
domain//Immunoglobulin domain [1040] PLACE60181870//Pentaxin family
[1041] PLACE60184870//LBP/BPI/CETP family [1042]
PROST10001100//Keratin, high sulfur B2 protein [1043]
PROST20007170//KRAB box//Zinc finger, C2H2
type//Cyclopropane-fatty-acyl-phospholipid synthase//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Transcription factor
S-II (TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type [1044] PROST20015210//Myosin tail//Borrelia
lipoproteins//Myosin tail [1045] PROST20016760//`chromo`
(CHRromatin Organization MOdifier) domain [1046]
PROST20024250//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type [1047] PROST20028970//Ank
repeat//Ank repeat//Glutamine amidotransferases class-II//Ank
repeat//Ank repeat [1048] PROST20033240//Ephrin receptor ligand
binding domain//EB module//TNFR/NGFR cysteine-rich
region//Fibronectin type III domain [1049]
PROST20036350//Glutathione S-transferases.//Ribosomal protein
S24e//Interferon alpha/beta domain//tRNA synthetases class I (E and
Q) [1050] PROST20045700//Keratin, high sulfur B2 protein [1051]
PROST20050390//Cytochrome P450 [1052] PROST20051310//DEAD/DEAH box
helicase//Toprim domain//Helicases conserved C-terminal
domain//Zinc knuckle [1053]
PROST20065790//Phosphofructokinase//Phosphofructokinase//Phosphofructokin-
ase//Phosphofructokinase [1054] PROST20073280//Transposase [1055]
PROST20075280//Immunoglobulin domain//Immunoglobulin
domain//Thrombospondin type 1 domain [1056]
PROST20082430//Cyclophilin type peptidyl-prolyl cis-trans isomerase
[1057] PROST20084720//Cytochrome P450 [1058] PROST20087240//gag
gene protein p24 (core nucleocapsid protein) [1059]
PROST20099090//Disintegrin [1060] PROST20102190//EF hand//Ribosomal
RNA adenine dimethylases//EF hand [1061]
PROST20105450//Sodium/hydrogen exchanger family [1062]
PROST20127450//TSC-22/dip/bun family [1063]
PROST20130320//S-100/ICaBP type calcium binding domain [1064]
PROST20152510//TPR Domain//TPR Domain//TPR Domain [1065]
PROST20155370//SCAN domain//KRAB box//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type [1066] PROST20168600//KTN NAD-binding
domain [1067] PUAEN10000650//TSC-22/dip/bun family [1068]
PUAEN10001640//Leucine Rich Repeat//Leucine Rich Repeat//Leucine
Rich Repeat//Leucine Rich Repeat [1069] PUAEN20000800//Bleomycin
resistance protein [1070] PUAEN20001520//Acetyltransferase (GNAT)
family [1071] PUAEN20002470//FtsK/SpoIIIE family [1072]
PUAEN20003120//Myb-like DNA-binding domain//ATP synthase ab C
terminal//SET domain [1073] SALGL10001070//Family 4 glycosyl
hydrolase [1074] SKMUS20006790//von Willebrand factor type D domain
[1075] SKMUS20007260//Syndecan domain [1076]
SKMUS20008730//Calponin homology (CH) domain [1077]
SKMUS20017400//Hantavirus nucleocapsid protein//Tropomyosins [1078]
SKMUS20040440//Ribosomal protein L3 [1079] SKMUS20091900//Trypsin
[1080] SKNMC10001230//Ank repeat//Ank repeat//Ank repeat [1081]
SKNMC20006350//FKBP-type peptidyl-prolyl cis-trans
isomerases//FKBP-type peptidyl-prolyl cis-trans
isomerases//FKBP-type peptidyl-prolyl cis-trans isomerases//EF
hand//EF hand [1082] SKNSH20009710//Tropomyosins//Tropomyosins
[1083] SKNSH20052400//WD domain, G-beta repeat//WD domain, G-beta
repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD
domain, G-beta repeat//WD domain, G-beta repeat [1084]
SKNSH20057920//Eukaryotic protein kinase domain [1085]
SMINT20000070//Rabphilin-3A effector domain [1086]
SMINT20002320//Protein phosphatase 2A regulatory B subunit (B56
family) [1087] SMINT20006020//PH domain//Phorbol
esters/diacylglycerol binding domain (C1 domain)//FYVE zinc
finger//PH domain [1088] SMINT20006090//Glutathione S-transferases.
[1089] SMINT20008110//Na+/K+ ATPase C-terminus [1090]
SMINT20011950//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2
type//PHD-finger//Zinc finger, C2H2 type [1091]
SMINT20012220//Collagen triple helix repeat (20 copies) [1092]
SMINT20016150//gag gene protein p17 (matrix protein).//Ferritins
[1093] SMINT20024140//Immunoglobulin domain [1094]
SMINT20028800//Zinc finger, C2HC type//SAM domain (Sterile alpha
motif)//Sterile alpha motif (SAM)/Pointed domain [1095]
SMINT20028840//Immunoglobulin domain [1096] SMINT20030740//KRAB
box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type [1097] SMINT20035050//SH3
domain//WW domain//PH domain//RhoGAP domain [1098]
SMINT20036440//ENTH domain [1099] SMINT20038660//Olfactomedin-like
domain [1100] SMINT20039050//Flavivirus glycoprotein//IBR domain
[1101] SMINT20043390//Ras association (RalGDS/AF-6) domain [1102]
SMINT20044140//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2
type//Zinc finger, C2H2 type [1103] SMINT20044730//Envelope
glycoprotein GP120 [1104] SMINT20048720//Cytochrome
P450//Cytochrome P450 [1105] SMINT20052130//Ank repeat//Ank repeat
[1106] SMINT20056230//Immunoglobulin domain//Immunoglobulin
domain//Immunoglobulin domain//Immunoglobulin domain [1107]
SMINT20062050//Reverse transcriptase (RNA-dependent DNA polymerase)
[1108] SMINT20077960//Gelsolin repeat.//Gelsolin repeat.//Gelsolin
repeat.//Gelsolin repeat. [1109] SMINT20083290//Immunoglobulin
domain//Immunoglobulin domain//Immunoglobulin
domain//Immunoglobulin domain//Immunoglobulin domain [1110]
SMINT20086250//Glycine cleavage H-protein [1111]
SMINT20086720//SCAN domain//KRAB box [1112]
SMINT20088440//Immunoglobulin domain [1113] SMINT20089600//PDZ
domain (Also known as DHR or GLGF). [1114]
SMINT20091190//Immunoglobulin domain//Immunoglobulin
domain//Immunoglobulin domain//Immunoglobulin
domain//Immunoglobulin domain [1115] SPLEN20006950//Reverse
transcriptase (RNA-dependent DNA polymerase) [1116]
SPLEN20011350//Helper component proteinase [1117]
SPLEN20015100//DHHC zinc finger domain [1118] SPLEN20023540//RasGEF
domain//EF hand//EF hand [1119] SPLEN20023850//RecF protein//SMC
domain N terminal domain//Tropomyosins [1120]
SPLEN20024190//EGF-like domain//EB module//EGF-like domain//Trypsin
Inhibitor like cysteine rich domain//EGF-like domain//EGF-like
domain//WAP-type (Whey Acidic Protein) `four-disulfide
core`//EGF-like domain [1121] SPLEN20024930//Inositol polyphosphate
phosphatase family, catalytic domain [1122] SPLEN20039180//Fatty
acid desaturase [1123] SPLEN20042200//Zinc finger, C3HC4 type (RING
finger)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type [1124]
SPLEN20049840//Polyphosphate kinase//Myosin head (motor domain)//IQ
calmodulin-binding motif//SH3 domain [1125]
SPLEN20050090//Pyridoxamine 5'-phosphate oxidase//GRIP domain
[1126] SPLEN20054500//Renal dipeptidase [1127] SPLEN20055600//K+
channel tetramerisation domain//BTB/POZ domain//Zinc finger, C2H2
type [1128] SPLEN20057900//Scorpion short toxins//EGF-like
domain//EGF-like domain//Keratin, high sulfur B2 protein [1129]
SPLEN20059270//Zinc finger, C3HC4 type (RING finger)//B-box zinc
finger.//SPRY domain [1130] SPLEN20063250//Zinc finger, C2H2 type
[1131] SPLEN20063890//Leucine Rich Repeat//Leucine Rich
Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich
Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich
Repeat//Leucine Rich Repeat [1132] SPLEN20071820//DNA polymerase X
family [1133] SPLEN20076470//TPR Domain//TPR Domain//TPR Domain
[1134] SPLEN20080070//Alpha-L-fucosidase [1135]
SPLEN20085910//Double-stranded RNA binding motif [1136]
SPLEN20090880//Immunoglobulin domain [1137] SPLEN20098030//Zinc
finger, C3HC4 type (RING finger)//B-box zinc finger. [1138]
SPLEN20101950//Sodium/hydrogen exchanger family [1139]
SPLEN20104150//Ribosomal protein L36 [1140] SPLEN20108000//short
chain dehydrogenase [1141] SPLEN20110180//Transposase [1142]
SPLEN20118050//Leucine rich repeat N-terminal domain//Leucine Rich
Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich
Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich
Repeat//Leucine Rich Repeat [1143] SPLEN20135030//PDZ domain (Also
known as DHR or GLGF).//GATA zinc finger//LIM domain containing
proteins [1144] SPLEN20139100//Sodium and potassium
ATPases//Immunoglobulin domain//Immunoglobulin
domain//Immunoglobulin domain//Immunoglobulin domain [1145]
SPLEN20139360//Bacterial regulatory proteins, lacI
family//Site-specific recombinases [1146]
SPLEN20175920//Uncharacterized protein family UPF0036 [1147]
SPLEN20180980//Glutathione S-transferases. [1148]
SPLEN20182990//BTB/POZ domain//Kelch motif//Kelch motif//Kelch
motif//Kelch motif [1149] SPLEN20183020//Laminin G domain [1150]
SPLEN20191020//Src homology domain 2 [1151] SPLEN20193790//Dynamin
family//Dynamin family//Proteasome activator pa28 beta
subunit//Peroxidase//Dynamin central region//Dynamin GTPase
effector domain [1152] SPLEN20195710//TPR Domain//TPR Domain//TPR
Domain [1153] SPLEN20197930//K-box region [1154] SPLEN20198390//WD
domain, G-beta repeat//Fibrillarin//WD domain, G-beta repeat//WD
domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta
repeat//WD domain, G-beta repeat//WD domain, G-beta repeat [1155]
SPLEN20201830//Leucine Rich Repeat//Leucine Rich Repeat//Leucine
Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich
Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Leucine Rich
Repeat [1156] TESTI10001570//KRAB box//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2
type//PHD-finger//Zinc finger, C2H2 type//Zinc finger, C2H2
type//TRAF-type zinc finger//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2 type
[1157] TESTI20006160//Large-conductance mechanosensitive channel,
MscL//CbiM [1158] TESTI20006830//PWWP domain [1159]
TESTI20012080//Chitin synthase [1160] TESTI20016970//TPR Domain
[1161] TESTI20030200//Double-stranded RNA binding
motif//Adenosine-deaminase (editase) domain//Adenosine-deaminase
(editase) domain [1162] TESTI20030440//Plant PEC family
metallothionein//Tropomyosins [1163] TESTI20031310//Serpins (serine
protease inhibitors) [1164] TESTI20038240//Peptidase family M13
[1165] TESTI20041630//Outer membrane efflux protein//Intermediate
filament proteins [1166] TESTI20043910//IQ calmodulin-binding
motif//IQ calmodulin-binding motif//IQ calmodulin-binding motif//IQ
calmodulin-binding motif//IQ calmodulin-binding motif [1167]
TESTI20045390//Immunoglobulin domain//Immunoglobulin
domain//Immunoglobulin domain//Immunoglobul in domain//Immunoglobul
in domain//Immunoglobulin domain//Immunoglobulin domain [1168]
TESTI20046110//Extracellular link domain [1169] TESTI20046490//LIM
domain containing proteins//Somatomedin B domain [1170]
TESTI20046870//CRAL/TR10 domain.//CRAL/TR10 domain.//MSP (Major
sperm protein) domain [1171] TEST120046890//PHD-finger [1172]
TESTI20049060//Immunoglobulin domain [1173]
TESTI20049410//Proprotein convertase P-domain [1174]
TESTI20050720//Coenzyme A transferase//Alpha-2-macroglobulin family
N-terminal region//Coenzyme A transferase [1175]
TESTI20051730//Glutamine amidotransferases class-II//alpha/beta
hydrolase fold [1176] TESTI20053070//WD domain, G-beta repeat//WD
domain, G-beta repeat [1177] TESTI20053950//IQ calmodulin-binding
motif [1178] TESTI20055880//Serum amyloid A protein [1179]
TESTI20056030//Myosin tail [1180] TESTI20057430//KRAB box//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2
type//PHD-finger//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Transcription factor S-II (TFIIS)//Zinc finger, C2H2
type//Zinc finger, C2H2 type [1181] TESTI20057590//Leucine rich
repeat C-terminal domain//Immunoglobulin domain [1182]
TESTI20057840//SAP domain//Zinc knuckle//Zinc finger, C3HC4 type
(RING finger) [1183] TESTI20057880//Zinc finger, C3HC4 type (RING
finger) [1184] TESTI20058350//Polyomavirus coat protein//WD domain,
G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta
repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD
domain, G-beta repeat [1185] TESTI20058920//Tubulin/FtsZ family
[1186] TESTI20059080//Thermophilic metalloprotease
(M29)//Hyaluronidase [1187] TESTI20059480//Cyclic
nucleotide-binding domain [1188] TESTI20059810//KRAB box//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II
(TFIIS)//Zinc finger, C2H2 type//DM DNA binding domain//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//BolA-like protein//Zinc
finger, C2H2-type//Coronavirus M matrix/glycoprotein//Zinc finger,
C2H2 type//Zinc finger, C2H2 type [1189] TESTI20060350//bZIP
transcription factor [1190] TESTI20060830//ZAP domain//Ferric
uptake regulator family//Peptidase family M1//Piwi domain [1191]
TESTI20061090//Keratin, high sulfur B2 protein [1192]
TESTI20061200//Sugar (and other) transporter [1193]
TESTI20064370//TPR Domain//TPR Domain//TPR Domain//TPR
Domain//Synaptobrevin [1194] TESTI20064530//WD domain, G-beta
repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD
domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta
repeat [1195] TESTI20064650//Myosin head (motor domain) [1196]
TESTI20065650//G-protein alpha subunit [1197]
TESTI20066150//Picornavirus 2B protein//Glutamine amidotransferase
class-I//Pancreatic hormone peptides [1198]
TESTI20066330//Fibronectin type III domain [1199]
TESTI20066650//RasGEF domain [1200] TESTI20067480//KRAB box//Zinc
finger, C2H2 type//TRAF-type zinc finger//Zinc finger, C2H2
type//Zinc finger, C2H2 type//PHD-finger//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//FYVE
zinc finger//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type [1201] TESTI20068530//Zinc finger, C3HC4 type
(RING finger)//PHD-finger [1202] TESTI20071130//ATP synthase Alpha
chain, C terminal [1203] TESTI20071630//Glutamine
synthetase//SCP-like extracellular protein [1204]
TESTI20075240//KRAB box//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Putative zinc finger in N-recognin//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Transcription factor S-II (TFIIS)//Zinc finger,
C2H2 type//Zinc finger, C2H2 type [1205] TESTI20076570//Dual
specificity phosphatase, catalytic domain [1206]
TESTI20079220//KRAB box//Myb-like DNA-binding domain//Myb-like
DNA-binding domain//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type//PHD-finger//Transcription factor S-II
(TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type [1207] TESTI20079980//PDZ domain (Also known as
DHR or GLGF).//Domain found in Dishevelled, Egl-10, and Pleckstrin
[1208] TESTI20081890//PDZ domain (Also known as DHR or GLGF).
[1209] TESTI20084250//Oxysterol-binding protein [1210]
TESTI20086840//von Willebrand factor type A domain [1211]
TESTI20088840//Zinc finger, C3HC4 type (RING
finger)//PHD-finger//Thymidine kinases//E7 protein, Early
protein//CONSTANS family zinc finger//B-box zinc finger.//SPRY
domain [1212] TESTI20092170//ENV polyprotein (coat polyprotein)
[1213] TEST120095200//7TM chemoreceptor [1214] TESTI20095770//WD
domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta
repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD
domain, G-beta repeat//WD domain, G-beta repeat [1215]
TESTI20095880//Domain of unknown function DUF33//Penicillin
amidase//Formate/nitrite transporter//Sodium:galactoside symporter
family [1216] TESTI20099350//GGL
domain//Clusterin//Biopterin-dependent aromatic amino acid
hydroxylase [1217] TESTI20100090//Lectin C-type domain [1218]
TESTI20104090//TEA domain [1219] TESTI20105910//Notch (DSL)
domain//Amiloride-sensitive sodium channel [1220] TESTI20106170//WD
domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta
repeat//WD domain, G-beta repeat//WD domain, G-beta repeat [1221]
TESTI20106820//Protein kinase C terminal domain [1222]
TESTI20108060//Ser/Thr protein phosphatase [1223]
TESTI20112540//Leucine Rich Repeat//Leucine Rich Repeat//Leucine
Rich Repeat//Leucine Rich Repeat//Chorismate synthase//UvrB/uvrC
motif [1224] TESTI20112860//Eukaryotic protein kinase domain [1225]
TESTI20113940//Divalent cation transporter [1226]
TEST120114480//Zinc finger, C4 type (two domains)//Zinc finger,
C2HC type//SAM domain (Sterile alpha motif)//Sterile alpha motif
(SAM)/Pointed domain [1227] TESTI20116050//UBX domain [1228]
TESTI20120500//Kelch motif//Kelch motif [1229] TESTI20120900//DNA
gyrase/topoisomerase IV, subunit A [1230] TESTI20121040//Protein
phosphatase 2C//Protein phosphatase 2C [1231] TESTI20122070//ELM2
domain//Myb-like DNA-binding domain [1232]
TESTI20125280//Immunoglobulin domain//Immunoglobulin domain [1233]
TESTI20125920//PCI domain [1234] TESTI20126280//recA bacterial DNA
recombination proteins [1235] TESTI20131440//Carboxypeptidase
activation peptide//Zinc carboxypeptidase [1236]
TESTI20132310//Ubiquitin carboxyl-terminal hydrolase family 2
[1237] TESTI20134680//MYND finger//B-box zinc finger.//CONSTANS
family zinc finger//Putative zinc finger in N-recognin [1238]
TESTI20134970//Double-stranded RNA binding motif//Aldehyde oxidase
and xanthine dehydrogenase, C terminus//Adenosine-deaminase
(editase) domain [1239] TESTI20140970//Immunoglobulin domain [1240]
TESTI20145780//Src homology domain 2 [1241] TESTI20148380//TPR
Domain//TPR Domain//TPR Domain//TPR Domain//TPR Domain//TPR
Domain//PPR repeat//Neuraminidases//ATP synthase Alpha chain, C
terminal//TPR Domain//TPR Domain//TPR Domain//TPR Domain//PPR
repeat//TPR Domain [1242] TESTI20150420//RhoGAP domain [1243]
TESTI20150920//Leucine Rich Repeat//Leucine Rich Repeat//Leucine
Rich Repeat//Leucine Rich Repeat//Leucine Rich Repeat [1244]
TESTI20153310//Intermediate filament tail domain [1245]
TESTI20162780//Divalent cation transporter [1246]
TESTI20162980//Ubiquitin family//Retroviral aspartyl
protease//Retroviral aspartyl protease [1247]
TESTI20164210//Isocitrate and isopropylmalate
dehydrogenases//Ribosomal protein S27a//TILa domain//von Willebrand
factor type C domain [1248] TESTI20165990//Ribosomal protein L36
[1249] TESTI20166290//Zinc finger, C2H2 type//FAD binding
domain//Phosphoenolpyruvate carboxykinase//Ribosomal protein S11
[1250] TESTI20166670//Zinc finger C-x8-C-x5-C-x3-H type (and
similar). [1251] TESTI20169500//GGL domain [1252]
TESTI20170280//Flagellar L-ring protein [1253] TESTI20173960//KRAB
box//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//PHD-finger//Zinc finger,
C2H2 type//Zinc finger, C2H2 type t [1254]
TESTI20179230//Dihydropyridine sensitive L-type calcium channel
(Beta subunit) [1255] TESTI20182760//Amiloride-sensitive sodium
channel [1256] TESTI20183680//Gas vesicles protein GVPc repeated
domain [1257] TESTI20184750//Laminin G domain//Thrombospondin
N-terminal-like domains//Laminin G domain [1258]
TESTI20184760//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//PHD-finger//Transcription factor S-II
(TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type [1259] TESTI20186110//Divalent cation
transporter//Translation initiation factor IF-3//Divalent cation
transporter [1260] TESTI20193080//Growth-Arrest-Specific Protein 2
Domain [1261] TESTI20194880//SAP domain [1262]
TESTI20196690//Glycine cleavage T-protein (aminomethyl transferase)
[1263] TEST120197030//Pancreatic hormone peptides [1264]
TESTI20197600//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type [1265]
TESTI20199110//Disintegrin [1266] TESTI20205100//DNA
gyrase/topoisomerase IV, subunit A [1267] TESTI20205250//MORN
motif//MORN motif//MORN motif//MORN motif//MORN motif//MORN
motif//MORN motif [1268] TESTI20207170//Nucleosome assembly protein
(NAP) [1269] TESTI20210570//CRAL/TR10 domain. [1270]
TESTI20212970//DEAD/DEAH box helicase//Helicases conserved
C-terminal domain [1271] TESTI20219110//Eukaryotic protein kinase
domain [1272] TESTI20222030//Hemagglutinin//ATP synthase Alpha
chain, C terminal//AMP-binding enzyme [1273]
TESTI20222460//Intermediate filament proteins [1274]
TESTI20227380//DEAD/DEAH box helicase//Helicases conserved
C-terminal domain [1275] TESTI20228120//RhoGAP domain [1276]
TESTI20228740//Zinc finger, C2H2 type [1277]
TESTI20244220//Cecropin family//Fes/CIP4 homology domain//Hr1
repeat motif//SH3 domain [1278] TESTI20244430//Ank repeat//Ank
repeat//Ank repeat//SAM domain (Sterile alpha motif) [1279]
TESTI20244460//pKID domain//Adenylate kinase//Thymidylate
kinase//ATPases associated with various cellular activities (AAA)
[1280] TESTI20246480//RNA recognition motif. (a.k.a. RRM, RBD, or
RNP domain) [1281] TESTI20251610//Chitin synthase//von Willebrand
factor type A domain [1282] TESTI20252690//Domain found in
Dishevelled, Egl-10, and Pleckstrin [1283] TESTI20254030//LIM
domain containing proteins//LIM domain containing proteins//Villin
headpiece domain [1284] TESTI20254990//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type [1285] TESTI20255460//ZAP
domain//Piwi domain [1286] TESTI20257910//Class I
Histocompatibility antigen, domains alpha 1 and 2//Immunoglobulin
domain [1287] TESTI20258720//Ank repeat//Ank repeat//Ank repeat
[1288] TESTI20259110//Zinc finger, C3HC4 type (RING
finger)//PHD-finger [1289] TESTI20261040//DNA polymerase (viral)
C-terminal domain [1290] TESTI20261160//PH domain [1291]
TESTI20261680//Hsp20/alpha crystallin family//Granulins [1292]
TESTI20262150//Ion transport protein [1293]
TESTI20262940//Phosphofructokinase [1294] TESTI20264530//WD domain,
G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta
repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//C.
elegans integral membrane protein Srb//WD domain, G-beta repeat//WD
domain, G-beta repeat//SAM domain (Sterile alpha motif)//Sterile
alpha motif (SAM)/Pointed domain [1295] TESTI20264910//Uteroglobin
family [1296] TESTI20266050//Zinc finger, C3HC4 type (RING
finger)//SPRY domain [1297] TESTI20274960//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//Transcription factor S-II
(TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type [1298]
TESTI20278280//PMP-22/EMP/MP20/Claudin family [1299]
TESTI20282530//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Zinc finger, C2H2 type [1300]
TESTI20284260//Histone-like transcription factor (CBF/NF-Y) and
archaeal histone//Core histone H2A/H.sub.2B/H3/H4 [1301]
TESTI20285230//Adenosine-deaminase (editase) domain [1302]
THYMU10004280//NHL-repeat//NHL repeat [1303]
THYMU20006020//Isocitrate and isopropylmalate dehydrogenases [1304]
THYMU20009500//TPR Domain [1305] THYMU20013250//LIM domain
containing proteins//RI01/ZK632.3/MJ0444 family//Eukaryotic protein
kinase domain [1306] THYMU20018250//TPR Domain [1307]
THYMU20019260//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type [1308] THYMU20021090//SAM
domain (Sterile alpha motif)//Sterile alpha motif (SAM)/Pointed
domain [1309] THYMU20028150//Immunoglobulin domain//Immunoglobulin
domain//Immunoglobulin domain//Immunoglobulin domain [1310]
THYMU20028410//BRCA1 C Terminus (BRCT) domain//BRCA1 C Terminus
(BRCT) domain [1311] THYMU20031330//4Fe-4S iron sulfur cluster
binding proteins, NifH/frxC family [1312] THYMU20032820//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type [1313]
THYMU20039320//WD domain, G-beta repeat//WD domain, G-beta
repeat//WD domain, G-beta repeat//WD domain, G-beta repeat [1314]
THYMU20046350//Cytochrome C and Quinol oxidase polypeptide I [1315]
THYMU20049060//RNA recognition motif. (a.k.a. RRM, RBD, or RNP
domain) [1316] THYMU20052830//Immunoglobulin domain//Immunoglobulin
domain//Immunoglobulin domain//Immunoglobulin domain
[1317] THYMU20055450//Zona pellucida-like domain [1318]
THYMU20055460//Putative esterase [1319] THYMU20055760//Na+/K+
ATPase C-terminus//Phospholipase A2 [1320] THYMU20062770//Zona
pellucida-like domain [1321] THYMU20063650//Ribulose-phosphate 3
epimerase family//Indole-3-glycerol phosphate synthases [1322]
THYMU20066660//DEAD/DEAH box helicase [1323]
THYMU20070250//Transketolase//Dehydrogenase E1
component//Transketolase [1324] THYMU20071120//KRAB box//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type [1325] THYMU20077250//HMG (high mobility group) box
[1326] THYMU20081110//LIM domain containing proteins [1327]
THYMU20083390//11S plant seed storage protein [1328]
THYMU20090230//RNA recognition motif. (a.k.a. RRM, RBD, or RNP
domain) [1329] THYMU20095920//Iron hydrogenase small subunit [1330]
THYMU20097920//PH domain//FERM domain (Band 4.1 family) [1331]
THYMU20098350//bZIP transcription factor//bZIP transcription
factor//Tubulin/FtsZ family//Intermediate filament proteins [1332]
THYMU20099060//Immunoglobulin domain//Immunoglobulin
domain//Immunoglobulin domain//Immunoglobulin
domain//Immunoglobulin domain [1333] THYMU20100940//Protein of
unknown function DUF132 [1334] THYMU20104480//RNA recognition
motif. (a.k.a. RRM, RBD, or RNP domain) [1335] THYMU20106990//PH
domain [1336] THYMU20110720//Aminotransferases class-III
pyridoxal-phosphate [1337] THYMU20112590//Acyl-CoA
dehydrogenase//Adaptin N terminal region [1338]
THYMU20120240//Ubiquitin carboxyl-terminal hydrolases family
2//Ubiquitin carboxyl-terminal hydrolase family 2 [1339]
THYMU20120730//Aldehyde dehydrogenase family [1340]
THYMU20121040//bZIP transcription factor//EF-1 guanine nucleotide
exchange domain [1341] THYMU20139160//Uncharacterized protein
family UPF0031 [1342] THYMU20143230//EGF-like domain//Extracellular
link domain//Fasciclin domain [1343] THYMU20145990//SH3 domain
[1344] THYMU20153210//7 transmembrane receptor (Secretin family)
[1345] THYMU20170230//Glycine cleavage T-protein (aminomethyl
transferase) [1346] THYMU20176010//WD domain, G-beta repeat//PQQ
enzyme repeat//WD domain, G-beta repeat//WD domain, G-beta
repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD
domain, G-beta repeat//WD domain, G-beta repeat//WD domain, G-beta
repeat [1347] THYMU20178440//Immunoglobulin domain//Immunoglobulin
domain//Immunoglobulin domain//Immunoglobulin domain [1348]
THYMU20184550//HSF-type DNA-binding domain//bZIP transcription
factor [1349] THYMU20191970//Cadherin domain//Cadherin
domain//Cadherin domain//Cadherin domain [1350]
TKIDN10000620//Thioredoxin [1351] TKIDN10001920//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type [1352]
TRACH20011010//5'-nucleotidase [1353] TRACH20021380//Copper/zinc
superoxide dismutase (SODC)//Adenylate and Guanylate cyclase
catalytic domain//Adenylate and Guanylate cyclase catalytic domain
[1354] TRACH20029880//MORN motif//MORN motif//Penicillin
amidase//Bacterial regulatory proteins, lacI family//Vacuolar
sorting protein 9 (VPS9) domain [1355]
TRACH20040390//Pumilio-family RNA binding domains (aka PUM-HD,
Pumilio homology domain)//Pumilio-family RNA binding domains (aka
PUM-HID, Pumilio homology domain)//Pumilio-family RNA binding
domains (aka PUM-HD, Pumilio homology domain)//Pumilio-family RNA
binding domains (aka PUM-HD, Pumilio homology
domain)//Pumilio-family RNA binding domains (aka PUM-HD, Pumilio
homology domain)//Pumilio-family RNA binding domains (aka PUM-HD,
Pumilio homology domain)//Pumilio-family RNA binding domains (aka
PUM-HD, Pumilio homology domain)//Pumilio-family RNA binding
domains (aka PUM-HD, Pumilio homology domain) [1356]
TRACH20043360//Kinesin motor domain//Caspase recruitment
domain//Ribosomal protein L35 [1357] TRACH20058000//Fibronectin
type III domain [1358] TRACH20090060//C2 domain [1359]
TRACH20091070//Aldehyde dehydrogenase family [1360]
TRACH20093400//Adaptin N terminal region [1361]
TRACH20098510//Ribosomal L29 protein [1362]
TRACH20104510//Uncharacterized protein family UPF0005 [1363]
TRACH20108240//RNA recognition motif. (a.k.a. RRM, RBD, or RNP
domain)//RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain)
[1364] TRACH20113020//AIR synthase related protein [1365]
TRACH20122980//TPR Domain//TPR Domain//TPR Domain//TPR Domain//TPR
Domain [1366] TRACH20131230//PH domain//Oxysterol-binding protein
[1367] TRACH20139280//PX domain [1368] TRACH20143710//Leucine Rich
Repeat//Leucine Rich Repeat//Leucine Rich Repeat [1369]
TRACH20149500//Zinc finger//Plexin repeat//Cysteine rich
repeat//Intermediate filament proteins [1370]
TRACH20149740//Sodium:dicarboxylate symporter family [1371]
TRACH20163470//Putative integral membrane protein DUF46//Sugar (and
other) transporter//Sodium:galactoside symporter family [1372]
TRACH20164100//Retroviral aspartyl protease [1373]
TRACH20164810//D-isomer specific 2-hydroxyacid dehydrogenases
[1374] TRACH20167090//Chitinases, family 2 [1375]
TRACH20170860//Immunoglobulin domain//Immunoglobulin
domain//Immunoglobulin domain//Immunoglobulin domain [1376]
TRACH20188350//Tropomyosins [1377] TRACH20190460//Lipase (class 3)
[1378] UTERU20000950//WD domain, G-beta repeat//WD domain, G-beta
repeat//WD domain, G-beta repeat//WD domain, G-beta repeat//WD
domain, G-beta repeat [1379] UTERU20016580//Zinc finger present in
dystrophin, CBP/p300//Myb-like DNA-binding domain [1380]
UTERU20026620//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2 type
[1381] UTERU20041630//KRAB box//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Transcription factor S-II
(TFIIS)//Zinc finger, C2H2 type//Zinc finger, C2H2 type [1382]
UTERU20083020//Domain of unknown function DUF71 [1383]
UTERU20086530//Lipocalin/cytosolic fatty-acid binding protein
family [1384] UTERU20087070//Sushi domain (SCR repeat)//Trypsin
[1385] UTERU20089390//TPR Domain//TPR Domain//TPR Domain//TPR
Domain//TPR Domain//TPR Domain//TPR Domain//TPR Domain [1386]
UTERU20089620//Fringe-like [1387] UTERU20099040//Cation efflux
family [1388] UTERU20099510//KRAB box//Zinc finger, C2H2 type//Zinc
finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2
type//Zinc finger, C2H2 type//Zinc finger, C2H2 type//Zinc finger,
C2H2 type//Zinc finger, C2H2 type//Zinc finger, C2H2
type//PHD-finger//Zinc finger, C2H2 type [1389] UTERU20104310//RNA
polymerases K/14 to 18 kDa subunit [1390]
UTERU20121140//Rhodanese-like domain [1391] UTERU20122520//FERM
domain (Band 4.1 family)//FERM domain (Band 4.1 family) [1392]
UTERU20127030//Xylose isomerase//ApbE family [1393]
UTERU20127150//Translation initiation factor IF-3//Divalent cation
transporter [1394] UTERU20128560//Domain of unknown function DUF28
[1395] UTERU20132620//HMG14 and HMG17 [1396]
UTERU20139760//Mitochondrial carrier proteins//Mitochondrial
carrier proteins [1397] UTERU20168960//PH domain//Methanol
dehydrogenase beta subunit [1398] UTERU20181270//Zinc knuckle
[1399] UTERU20185220//Bromodomain
EXAMPLE 6
Functional Categorization Based on the Full-Length Nucleotide
Sequences
[1400] The functional prediction and categorization of the proteins
encoded by the clones were carried out based on the result of
homology search of the databases of GenBank, Swiss-Prot, UniGene
and nr (see the Homology Search Result Data) for the full-length
nucleotide sequences and the result of domain search of the amino
acid sequences deduced from the full-length nucleotide sequences
(see Example 5).
[1401] The clone predicted to belong to the category of secretory
protein/membrane protein means a clone having hit data with some
annotation, such as growth factor, cytokine, hormone, signal,
transmembrane, membrane, extracellular matrix, receptor, G-protein
coupled receptor, ionic channel, voltage-gated channel, calcium
channel, cell adhesion, collagen, connective tissue, etc.,
suggesting that it is a secretory or membrane protein, or means a
clone in which the presence of nucleotide sequence encoding a
signal sequence or transmembrane domain was suggested by the
results of PSORT and SOSUI analyses for deduced ORF.
[1402] The clone predicted to belong to the category of
glycoprotein-related protein means a clone having hit data with
some annotation, such as glycoprotein, suggesting that the clone
encodes a glycoprotein-related protein.
[1403] The clone predicted to belong to the category of signal
transduction-related protein means a clone having hit data with
some annotation, such as serine/threonine-protein kinase,
tyrosine-protein kinase, SH3 domain, SH2 domain, etc., suggesting
that the clone encodes a signal transduction-related protein.
[1404] The clone predicted to belong to the category of
transcription-related protein means a clone having hit data with
some annotation, such as transcription regulation, zinc finger,
homeobox, etc., suggesting that the clone encodes a
transcription-related protein.
[1405] The clone predicted to belong to the category of
disease-related protein means a clone having hit data with some
annotation, such as disease mutation, syndrome, etc., suggesting
that the clone encodes a disease-related protein, or means a clone
whose full-length nucleotide sequence has hit data for Swiss-Prot,
GenBank, or UniGene, where the hit data corresponds to genes or
proteins which have been deposited in the Online Mendelian
Inheritance in Man (OMIM) (http://www.ncbi.nlm.nih.gov/Omim/),
which is the human gene and disease database.
[1406] The clone predicted to belong to the category of enzyme
and/or metabolism-related protein means a clone having hit data
with some annotation, such as metabolism, oxidoreductase, E. C. No.
(Enzyme commission number), etc., suggesting that the clone encodes
an enzyme and/or metabolism-related protein.
[1407] The clone predicted to belong to the category of cell
division and/or cell proliferation-related protein means a clone
having hit data with some annotation, such as cell division, cell
cycle, mitosis, chromosomal protein, cell growth, apoptosis, etc.,
suggesting that the clone encodes a cell division and/or cell
proliferation-related protein.
[1408] The clone predicted to belong to the category of
cytoskeleton-related protein means a clone having hit data with
some annotation, such as structural protein, cytoskeleton,
actin-binding, microtubles, etc., suggesting that the clone encodes
a cytoskeleton-related protein.
[1409] The clone which is predicted to belong to the category of
nuclear protein and/or RNA synthesis-related protein means a clone
having hit data with some annotation, such as nuclear protein, RNA
splicing, RNA processing, RNA helicase, polyadenylation, etc.,
suggesting that the clone encodes a nuclear protein and/or RNA
synthesis-related protein.
[1410] The clone predicted to belong to the category of protein
synthesis and/or transport-related protein means a clone having hit
data with some annotation, such as translation regulation, protein
biosynthesis, amino-acid biosynthesis, ribosomal protein, protein
transport, signal recognition particle, etc., suggesting that the
clone encodes a protein synthesis and/or transport-related
protein.
[1411] The clone predicted to belong to the category of cellular
defense-related protein means a clone having hit data with some
annotation, such as heat shock, DNA repair, DNA damage, etc.,
suggesting that the clone encodes a cellular defense-related
protein.
[1412] The clone predicted to belong to the category of development
and/or differentiation-related proteins means a clone having hit
data with some annotation, such as developmental protein, etc.,
suggesting that the clone encodes a development and/or
differentiation-related protein.
[1413] The clone predicted to belong to the category of DNA-binding
and/or RNA-binding protein means a clone having hit data with some
annotation, such as DNA-binding, RNA-binding, etc.
[1414] The clone predicted to belong to the category of ATP-binding
and/or GTP-binding protein means a clone having hit data with some
annotation, such as ATP-binding, GTP-binding, etc.
[1415] In this functional categorization, when a single clone
corresponded to multiple categories of those shown above, the clone
was assigned to the multiple categories. However, the function of a
protein is not restricted to the functional category in this
classification, and there is the possibility that other functions
are newly assigned to the protein.
[1416] The clones predicted to belong to the category of secretory
protein and/or membrane protein are the following 516 clones.
TABLE-US-00031 ADRGL20020290, ADRGL20021910, ADRGL20036380,
ADRGL20036840, ADRGL20059610, ADRGL20063770, ADRGL20066770,
ASTRO20010010, ASTRO20020240, ASTRO20045840, ASTRO20053430,
ASTRO20055530, ASTRO20055570, ASTRO20055930, ASTRO20088950,
ASTRO20091180, BNGH420021680, BNGH420023870, BNGH420046790,
BNGH420052350, BNGH420059680, BNGH420075940, BNGH420077980,
BRACE10000510, BRACE20051930, BRACE20052530, BRACE20054080,
BRACE20066360, BRACE20068710, BRACE20069000, BRACE20069110,
BRACE20194670, BRACE20204670, BRACE20216950, BRAMY10001730,
BRAMY20003880, BRAMY20013670, BRAMY20024790, BRAMY20027390,
BRAMY20028530, BRAMY20035380, BRAMY20044920, BRAMY20045210,
BRAMY20047560, BRAMY20050940, BRAMY20053910, BRAMY20055760,
BRAMY20072440, BRAMY20083820, BRAMY20089770, BRAMY20091230,
BRAMY20094890, BRAMY20096930, BRAMY20118410, BRAMY20123400,
BRAMY20125550, BRAMY20127310, BRAMY20127760, BRAMY20135720,
BRAMY20137360, BRAMY20139440, BRAMY20152510, BRAMY20194680,
BRAMY20204270, BRAMY20225320, BRAMY20237190, BRAMY20245140,
BRAMY20251750, BRAMY20285650, BRAWH20020470, BRAWH20021910,
BRAWH20026010, BRAWH20030000, BRAWH20039640, BRAWH20055330,
BRAWH20078620, BRAWH20093070, BRAWH20185270, BRCAN10000760,
BRCAN10001680, BRCAN20001480, BRCAN20004180, BRCAN20005230,
BRCOC20000470, BRCOC20003600, BRHIP10000720, BRHIP10001040,
BRHIP20000210, BRSSN20001970, BRSSN20074640, BRSSN20091190,
CD34C20001750, CTONG20017490, CTONG20036990, CTONG20041260,
CTONG20044870, CTONG20045500, CTONG20049480, CTONG20051450,
CTONG20055850, CTONG20056150, CTONG20059130, CTONG20060040,
CTONG20063770, CTONG20065680, CTONG20068360, CTONG20069320,
CTONG20071680, CTONG20076810, CTONG20078340, CTONG20079590,
CTONG20083980, CTONG20084020, CTONG20085210, CTONG20167750,
CTONG20168240, CTONG20179890, CTONG20183830, CTONG20184830,
DFNES20018000, DFNES20029660, DFNES20057660, DFNES20072990,
DFNES20080880, FCBBF20018680, FCBBF20029280, FCBBF20032930,
FCBBF20036360, FCBBF20054390, FCBBF30004340, FCBBF30022680,
FCBBF30029250, FCBBF30042610, FCBBF30062490, FCBBF30075970,
FCBBF30078600, FCBBF30091520, FCBBF30095410, FCBBF30105440,
FCBBF30118670, FCBBF30132660, FCBBF30135890, FCBBF30145670,
FCBBF30164510, FCBBF30169870, FCBBF30171230, FCBBF30172330,
FCBBF30177290, FCBBF30179740, FCBBF30195690, FCBBF30197840,
FCBBF30212210, FCBBF30223110, FCBBF30223210, FCBBF30225930,
FCBBF30230610, FCBBF30260480, FCBBF30266510, FCBBF30287940,
FCBBF50000610, FCBBF50004950, FEBRA20007820, FEBRA20018670,
FEBRA20031280, FEBRA20031810, FEBRA20038220, FEBRA20039260,
FEBRA20040230, FEBRA20040560, FEBRA20046280, FEBRA20080860,
FEBRA20084750, FEBRA20088810, FEBRA20115930, FEBRA20116650,
FEBRA20121950, FEBRA20141980, FEBRA20177800, FEBRA20182030,
FEBRA20191720, HCHON10001660, HCHON20015050, HEART10001490,
HEART20031680, HHDPC10001140, HHDPC20051850, HHDPC20082790,
HHDPC20088160, HLUNG20015070, HLUNG20015180, HLUNG20020850,
HLUNG20029490, HLUNG20032460, HLUNG20033350, HLUNG20034970,
HLUNG20037160, HLUNG20041540, HLUNG20042730, HLUNG20050760,
HLUNG20052300, HLUNG20060670, HLUNG20065990, HLUNG20074330,
HLUNG20081390, HLUNG20088750, HLUNG20092530, KIDNE20016360,
KIDNE20083150, KIDNE20084030, KIDNE20084040, KIDNE20084800,
KIDNE20086490, KIDNE20086660, KIDNE20094670, KIDNE20134130,
KIDNE20142900, KIDNE20143200, KIDNE20148080, KIDNE20160960,
KIDNE20163710, KIDNE20169180, KIDNE20182540, KIDNE20186170,
KIDNE20188630, KIDNE20189960, LIVER20007750, LIVER20010510,
LIVER20010990, LIVER20026440, LIVER20030650, LIVER20038000,
MESAN20007110, MESAN20008150, MESAN20021220, MESAN20027900,
MESAN20058110, MESAN20059570, MESAN20060430, MESAN20067430,
MESAN20084150, MESAN20095220, NT2NE20018740, NT2NE20021860,
NT2NE20039210, NT2NE20053230, NT2NE20059210, NT2NE20064780,
NT2NE20069580, NT2NE20080770, NT2NE20082130, NT2NE20092950,
NT2NE20140130, NT2NE20145250, NT2NE20146510, NT2NE20152620,
NT2NE20167660, NT2NE20181800, NT2RI20016240, NT2RI20021200,
NT2RI20033920, NT2RP70003110, NT2RP70027790, NT2RP70031070,
NT2RP70031480, NT2RP70056690, NT2RP70087140, NTONG20034540,
NTONG20053630, OCBBF20000740, OCBBF20012520, OCBBF20109780,
OCBBF20110210, OCBBF20110730, OCBBF20112280, OCBBF20118720,
OCBBF20120010, OCBBF20123200, OCBBF20155030, OCBBF20165900,
OCBBF20165910, OCBBF20170350, OCBBF20176650, OCBBF20185630,
OCBBF20191950, PANCR10000860, PEBLM20001800, PLACE50001290,
PLACE60004260, PLACE60006300, PLACE60053280, PLACE60055590,
PLACE60056910, PLACE60057860, PLACE60061370, PLACE60064740,
PLACE60070500, PLACE60087680, PLACE60104630, PLACE60107010,
PLACE60113340, PLACE60138840, PLACE60154450, PLACE60184870,
PROST10001100, PROST20011160, PROST20014150, PROST20035830,
PROST20045700, PROST20050390, PROST20065100, PROST20073280,
PROST20082430, PROST20084680, PROST20084720, PROST20099090,
PROST20105450, PROST20106060, PROST20108850, PROST20110120,
PROST20114100, PROST20146590, PROST20152510, PROST20168600,
PUAEN10000870, SKMUS20006790, SKMUS20020770, SKMUS20073150,
SKMUS20091900, SKNMC20006350, SKNSH20094350, SMINT20006090,
SMINT20008110, SMINT20024140, SMINT20028840, SMINT20045470,
SMINT20077960, SMINT20081330, SMINT20086250, SMINT20088440,
SMINT20088690, SMINT20092160, SPLEN20015100, SPLEN20017610,
SPLEN20017810, SPLEN20024190, SPLEN20024620, SPLEN20054500,
SPLEN20058180, SPLEN20063890, SPLEN20073880, SPLEN20080070,
SPLEN20090880, SPLEN20101950, SPLEN20104690, SPLEN20105100,
SPLEN20108000, SPLEN20110180, SPLEN20110860, SPLEN20118050,
SPLEN20121790, SPLEN20125230, SPLEN20136700, SPLEN20138600,
SPLEN20139100, SPLEN20175920, SPLEN20177400, SPLEN20182850,
SPLEN20183020, SPLEN20183950, SPLEN20190080, SPLEN20190770,
SPLEN20193230, SPLEN20193490, SPLEN20193790, SPLEN20201830,
SPLEN20204670, TESOP10000350, TESTI10000190, TESTI20006160,
TESTI20029100, TESTI20031310, TESTI20032770, TESTI20038240,
TESTI20043130, TESTI20043220, TESTI20045390, TESTI20046540,
TESTI20046870, TESTI20047370, TESTI20050400, TESTI20051200,
TESTI20051730, TESTI20053260, TESTI20053780, TESTI20057200,
TESTI20057590, TESTI20059080, TESTI20061200, TESTI20062120,
TESTI20063330, TESTI20063410, TESTI20063600, TESTI20066330,
TESTI20068530, TESTI20070400, TESTI20070740, TESTI20073460,
TESTI20086840, TESTI20095200, TESTI20095440, TESTI20095880,
TESTI20100090, TESTI20102390, TESTI20105910, TESTI20113940,
TESTI20116120, TESTI20121040, TESTI20121710, TESTI20131440,
TESTI20142540, TESTI20149880, TESTI20151800, TESTI20162780,
TESTI20170170, TESTI20173050, TESTI20182760, TESTI20183680,
TESTI20184750, TESTI20186110, TESTI20198540, TESTI20199110,
TESTI20202830, TESTI20204260, TESTI20210030, TESTI20214630,
TESTI20219110, TESTI20244730, TESTI20245600, TESTI20245860,
TESTI20246410, TESTI20251610, TESTI20257910, TESTI20260640,
TESTI20261040, TESTI20262150, TESTI20262940, TESTI20264910,
TESTI20271790, TESTI20278280, TESTI20282420, TESTI20282900,
TESTI20286590, THYMU20007020, THYMU20012020, THYMU20017270,
THYMU20020800, THYMU20025480, THYMU20028150, THYMU20030690,
THYMU20034790, THYMU20046350, THYMU20046770, THYMU20050010,
THYMU20052830, THYMU20054800, THYMU20055740, THYMU20055760,
THYMU20062770, THYMU20078240, THYMU20079690, THYMU20083390,
THYMU20087270, THYMU20100940, THYMU20115380, THYMU20137050,
THYMU20137570, THYMU20143230, THYMU20150190, THYMU20153210,
THYMU20154790, THYMU20163600, THYMU20171580, THYMU20178440,
THYMU20185470, TRACH20011010, TRACH20011540, TRACH20021380,
TRACH20073990, TRACH20081270, TRACH20090060, TRACH20149720,
TRACH20149740, TRACH20159390, TRACH20163470, TRACH20165330,
TRACH20167090, TRACH20173680, TRACH20190460, UMVEN10001380,
UTERU20035770, UTERU20040150, UTERU20045200, UTERU20064120,
UTERU20086530, UTERU20087070, UTERU20087850, UTERU20089300,
UTERU20089620, UTERU20095100, UTERU20099040, UTERU20103200,
UTERU20125810, UTERU20127030, UTERU20127150, UTERU20139760,
UTERU20188840
[1417] The clones predicted to belong to the category of
glycoprotein-related protein are the following 121 clones.
TABLE-US-00032 ADRGL20020290, ADRGL20036840, ADRGL20059610,
ADRGL20066770, ASTRO20055570, BNGH420046790, BNGH420077980,
BRACE20051930, BRACE20069000, BRACE20204670, BRACE20216950,
BRAMY20013670, BRAMY20089770, BRAMY20251210, BRAWH20039640,
BRCAN10000760, BRCAN20005230, BRCOC20003600, CD34C20001750,
CTONG20017490, CTONG20036990, CTONG20045500, CTONG20059130,
CTONG20079590, CTONG20085210, CTONG20184830, DFNES20018000,
DFNES20080880, FCBBF30004340, FCBBF30029250, FCBBF30062490,
FCBBF30091520, FCBBF30164510, FCBBF30171230, FCBBF30195690,
FCBBF30223210, FEBRA20038220, HCHON20015050, HLUNG20015070,
HLUNG20032460, HLUNG20037160, HLUNG20041540, KIDNE20142900,
KIDNE20169180, KIDNE20186170, KIDNE20189960, MESAN20021220,
MESAN20058110, NT2NE20064780, NT2NE20140130, NT2NE20155650,
NT2RP70056690, NTONG20053630, OCBBF20000740, OCBBF20012520,
OCBBF20110210, OCBBF20120010, OCBBF20165900, OCBBF20165910,
OCBBF20191950, PEBLM20001800, PLACE60004260, PLACE60087680,
PLACE60113340, PLACE60184870, PROST20033240, PROST20099090,
PROST20108850, PROST20146590, SKMUS20073150, SKNMC20006350,
SMINT20028840, SMINT20056230, SMINT20083290, SMINT20091190,
SPLEN20024620, SPLEN20063890, SPLEN20080070, SPLEN20090880,
SPLEN20118050, SPLEN20139100, SPLEN20183020, SPLEN20201830,
TESTI10000190, TESTI20031310, TESTI20043990, TESTI20045390,
TESTI20051200, TESTI20057590, TESTI20059080, TESTI20066330,
TESTI20086840, TESTI20100090, TESTI20105910, TESTI20154370,
TESTI20164210, TESTI20182760, TESTI20184750, TESTI20199110,
TESTI20219110, TESTI20220230, TESTI20245600, TESTI20251610,
TESTI20257910, TESTI20286590, THYMU20024500, THYMU20028150,
THYMU20052830, THYMU20062770, THYMU20099060, THYMU20170080,
THYMU20178440, TRACH20011010, TRACH20011540, TRACH20021380,
TRACH20149740, TRACH20170860, TRACH20190460, UTERU20086530,
UTERU20087070, UTERU20127030
[1418] The clones predicted to belong to the category of signal
transduction-related protein are the following 88 clones.
TABLE-US-00033 ASTRO20050810, ASTRO20052420, ASTRO20085080,
ASTRO20090680, BNGH420008150, BNGH420015760, BNGH420035290,
BNGH420086030, BRAMY20035830, BRAMY20043630, BRAMY20118490,
BRAMY20206340, BRAMY20244490, BRAMY20251210, BRAMY20263000,
BRAWH20093040, BRAWH20190550, CTONG20004520, CTONG20029030,
CTONG20030280, CTONG20063930, CTONG20070720, CTONG20189000,
FCBBF30001100, FCBBF30076310, FCBBF30100080, FCBBF30143550,
FCBBF30153170, FCBBF30175350, FCBBF30250980, FEBRA20090160,
FEBRA20173330, HCHON20000870, HLUNG20011260, HLUNG20084790,
KIDNE20089870, KIDNE20160360, LIVER20011640, MESAN20021130,
MESAN20027240, MESAN20065990, NT2NE20018890, NT2NE20042550,
NT2RP70075800, NTONG20043080, NTONG20048440, PLACE60071800,
PROST20033240, PROST20052850, PROST20065790, PROST20075280,
SKNSH20052400, SKNSH20057920, SMINT20006020, SMINT20035050,
SPLEN20023540, SPLEN20039180, SPLEN20048800, SPLEN20049840,
SPLEN20054160, SPLEN20085910, SPLEN20191020, SPLEN20198390,
TESTI20046490, TESTI20049060, TESTI20053070, TESTI20066650,
TESTI20081890, TESTI20095770, TESTI20106820, TESTI20112860,
TESTI20145780, TESTI20150420, TESTI20168880, TESTI20205250,
TESTI20228120, TESTI20244220, TESTI20244460, TESTI20251740,
TESTI20261160, TESTI20264530, THYMU20013250, THYMU20039320,
THYMU20106990, THYMU20145990, THYMU20170080, THYMU20176010,
TRACH20188350
[1419] The clones predicted to belong to the category of
transcription-related protein are the following 143 clones.
TABLE-US-00034 ASTRO20038400, ASTRO20075150, BNGH420070370,
BNGH420074600, BNGH420087430, BRACE20003310, BRACE20061620,
BRAMY20001510, BRAMY20040580, BRAMY20076100, BRAMY20111780,
BRAWH20040680, BRAWH20050740, BRAWH20080580, BRAWH20082920,
BRAWH20095900, BRSSN20066440, CTONG20020950, CTONG20044230,
CTONG20053990, CTONG20072930, CTONG20074000, CTONG20084660,
CTONG20186370, CTONG20186520, DFNES20028170, DFNES20046840,
DFNES20073320, FCBBF30003610, FCBBF30019140, FCBBF30021900,
FCBBF30093170, FCBBF30114850, FCBBF30129010, FCBBF30136230,
FCBBF30143550, FCBBF30220050, FCBBF30228940, FCBBF30263080,
FCBBF30285930, FCBBF50003530, FEBRA20026820, FEBRA20027070,
FEBRA20046510, FEBRA20057010, FEBRA20063720, FEBRA20170240,
HCHON10000150, HCHON20002650, HEART20019310, HLUNG20014590,
HLUNG20028110, HLUNG20063700, KIDNE20140870, LIVER20006260,
MESAN20016270, MESAN20038520, NT2NE20038870, NT2NE20053950,
NT2NE20060750, NT2NE20061030, NT2NE20079670, NT2NE20082600,
NT2RP70001120, NT2RP70029780, NT2RP70046410, NT2RP70057500,
NT2RP70075300, NT2RP70090870, OCBBF20116250, OCBBF20120950,
OCBBF20121910, OCBBF20156450, OCBBF20157970, OCBBF20166900,
OCBBF20175360, OCBBF20177540, PEBLM20003260, PLACE60052940,
PLACE60066970, PLACE60122970, PLACE60150510, PLACE60177880,
PROST20007170, PROST20024250, PROST20035170, PROST20127450,
PROST20151370, PROST20155370, PUAEN10000650, PUAEN20003120,
SMINT20011950, SMINT20026200, SMINT20030740, SMINT20039050,
SMINT20044140, SMINT20086720, SPLEN20042200, SPLEN20043680,
SPLEN20055600, SPLEN20059270, SPLEN20063250, SPLEN20098030,
SPLEN20197930, TESTI10001570, TESTI20057430, TESTI20057840,
TESTI20059810, TESTI20067480, TESTI20068790, TESTI20075240,
TESTI20079220, TESTI20088840, TESTI20104090, TESTI20122070,
TESTI20166670, TESTI20171070, TESTI20173960, TESTI20184760,
TESTI20194880, TESTI20197600, TESTI20228740, TESTI20254030,
TESTI20254990, TESTI20266050, TESTI20274960, TESTI20282530,
THYMU10004280, THYMU20019260, THYMU20032820, THYMU20071120,
THYMU20077250, TKIDN10001920, UTERU20016580, UTERU20026620,
UTERU20041630, UTERU20094830, UTERU20099510, UTERU20101150,
UTERU20169020, UTERU20177150, UTERU20185220, UTERU20188670
[1420] The clones predicted to belong to the category of
disease-related protein are the following 331 clones.
TABLE-US-00035 ADRGL20020290, ADRGL20021910, ADRGL20026790,
ADRGL20036840, ADRGL20059610, ADRGL20066770, ASTRO20038400,
ASTRO20052420, ASTRO20055570, ASTRO20075150, ASTRO20088950,
BNGH420008150, BNGH420086030, BRACE10000510, BRACE20003310,
BRACE20069000, BRACE20097540, BRACE20194670, BRACE20196180,
BRACE20204670, BRACE20216950, BRAMY20003540, BRAMY20005080,
BRAMY20035830, BRAMY20040580, BRAMY20043630, BRAMY20044920,
BRAMY20051820, BRAMY20056620, BRAMY20089770, BRAMY20111780,
BRAMY20152510, BRAMY20190550, BRAMY20221600, BRAMY20227860,
BRAMY20274510, BRAWH20082920, BRAWH20093040, BRAWH20095900,
BRAWH20190530, BRAWH20191980, BRCAN10000760, BRCAN10001050,
BRCAN20005230, BRSSN20066440, CTONG20004520, CTONG20029030,
CTONG20042640, CTONG20045500, CTONG20052780, CTONG20053990,
CTONG20070780, CTONG20070910, CTONG20072930, CTONG20083980,
CTONG20084660, CTONG20165750, CTONG20169040, CTONG20183430,
CTONG20183830, CTONG20186290, CTONG20189000, DFNES20016470,
DFNES20025500, DFNES20046840, DFNES20055400, DFNES20080880,
FCBBF10000230, FCBBF20035490, FCBBF20066340, FCBBF30002270,
FCBBF30002280, FCBBF30019140, FCBBF30053300, FCBBF30071500,
FCBBF30072440, FCBBF30076310, FCBBF30080730, FCBBF30100080,
FCBBF30115920, FCBBF30118670, FCBBF30129010, FCBBF30132050,
FCBBF30136230, FCBBF30153170, FCBBF30164510, FCBBF30166220,
FCBBF30171230, FCBBF30175350, FCBBF30194550, FCBBF30220050,
FCBBF30223210, FCBBF30259050, FCBBF30263080, FCBBF30275590,
FCBBF50001650, FEBRA20027070, FEBRA20045380, FEBRA20046200,
FEBRA20046510, FEBRA20057010, FEBRA20063720, FEBRA20078800,
FEBRA20087550, FEBRA20088810, FEBRA20090160, FEBRA20092760,
FEBRA20151750, FEBRA20170240, FEBRA20173330, FEBRA20191720,
HCHON10000150, HCHON20015050, HEART20009590, HEART20022200,
HEART20063100, HHDPC20081230, HLUNG20008460, HLUNG20014590,
HLUNG20032460, HLUNG20063700, HLUNG20065990, HLUNG20069350,
HLUNG20081530, HLUNG20082350, HLUNG20083330, HLUNG20085210,
KIDNE20081170, KIDNE20084040, KIDNE20088240, KIDNE20089870,
KIDNE20133460, KIDNE20134890, KIDNE20141700, KIDNE20142900,
KIDNE20150730, KIDNE20152440, KIDNE20160360, KIDNE20165390,
KIDNE20169180, KIDNE20173430, KIDNE20189960, LIVER20026440,
MESAN20006200, MESAN20021130, MESAN20033220, MESAN20056890,
MESAN20057240, MESAN20065990, MESAN20067430, MESAN20069530,
NESOP20004520, NT2NE20018890, NT2NE20026200, NT2NE20037050,
NT2NE20053950, NT2NE20061030, NT2NE20111190, NT2NE20117580,
NT2NE20119980, NT2NE20140130, NT2NE20141040, NT2RI20093010,
NT2RP70003110, NT2RP70046410, NT2RP70075300, NTONG20032100,
NTONG20034540, OCBBF20000740, OCBBF20012520, OCBBF20111600,
OCBBF20120010, OCBBF20156450, OCBBF20157970, OCBBF20191950,
PEBLM20001800, PEBLM20003260, PLACE60004260, PLACE60012620,
PLACE60054230, PLACE60054870, PLACE60062660, PLACE60087680,
PLACE60184870, PROST20015210, PROST20024250, PROST20036350,
PROST20050390, PROST20058860, PROST20063430, PROST20065790,
PROST20084720, PROST20099090, PROST20120070, PROST20127450,
PROST20146590, PROST20152510, PROST20168600, PUAEN10000650,
PUAEN20003120, SKMUS20008730, SKMUS20017400, SKMUS20040440,
SKMUS20073590, SKMUS20079150, SKNSH20009710, SMINT20002320,
SMINT20007470, SMINT20008110, SMINT20011950, SMINT20016150,
SMINT20026200, SMINT20030740, SMINT20049920, SMINT20077960,
SMINT20083290, SMINT20086250, SMINT20089600, SMINT20091190,
SPLEN20023540, SPLEN20024190, SPLEN20042200, SPLEN20043680,
SPLEN20055600, SPLEN20057830, SPLEN20059270, SPLEN20063890,
SPLEN20073500, SPLEN20080070, SPLEN20085910, SPLEN20090880,
SPLEN20098030, SPLEN20118050, SPLEN20136730, SPLEN20138600,
SPLEN20139100, SPLEN20139360, SPLEN20180980, SPLEN20187490,
SPLEN20193790, SPLEN20201830, TESTI10000190, TESTI20031310,
TESTI20035790, TESTI20041630, TESTI20049060, TESTI20050720,
TESTI20051200, TESTI20057430, TESTI20057590, TESTI20059080,
TESTI20062120, TESTI20067480, TESTI20071630, TESTI20099350,
TESTI20105130, TESTI20105910, TESTI20108060, TESTI20125920,
TESTI20130530, TESTI20131440, TESTI20134680, TESTI20142540,
TESTI20143180, TESTI20150420, TESTI20154370, TESTI20164210,
TESTI20166670, TESTI20168880, TESTI20171070, TESTI20182760,
TESTI20184750, TESTI20193080, TESTI20194880, TESTI20196970,
TESTI20197600, TESTI20201760, TESTI20207170, TESTI20219110,
TESTI20228740, TESTI20244430, TESTI20246480, TESTI20251740,
TESTI20252690, TESTI20254030, TESTI20257910, TESTI20258720,
TESTI20266050, TESTI20271790, TESTI20274960, TESTI20282530,
TESTI20286590, THYMU10004280, THYMU20006020, THYMU20013250,
THYMU20019260, THYMU20023560, THYMU20028150, THYMU20032820,
THYMU20034400, THYMU20055460, THYMU20063650, THYMU20070250,
THYMU20071120, THYMU20081110, THYMU20090230, THYMU20095920,
THYMU20098350, THYMU20099060, THYMU20120730, THYMU20121040,
THYMU20170080, THYMU20185650, THYMU20191970, TKIDN10000620,
TKIDN10001920, TRACH20011540, TRACH20091070, TRACH20143710,
TRACH20170860, UTERU10001060, UTERU20026620, UTERU20041630,
UTERU20086530, UTERU20087070, UTERU20087850, UTERU20099510,
UTERU20101150, UTERU20104310, UTERU20127030, UTERU20185220
[1421] In particular, hit data of the following 328 clones for
Swiss-Prot, or GenBank, UniGene, or nr corresponded to genes or
proteins which had been deposited in the Online Mendelian
Inheritance in Man (OMIM), which is the human gene and disease
database, (the OMIM Number is shown in the parenthesis after the
Clone Name). TABLE-US-00036 ADRGL20020290 (602193), ADRGL20021910
(605717), ADRGL20026790 (605046), ADRGL20036840 (142800),
ADRGL20059610 (230800; 230900; 231000; 231005), ADRGL20066770
(130660), ASTRO20038400 (604764), ASTRO20052420 (600888),
ASTRO20055570 (176640; 123400; 137440; 245300; 600072),
ASTRO20075150 (601896), ASTRO20088950 (603202; 223000; 223100),
BNGH420008150 (600050), BNGH420086030 (118423), BRACE10000510
(148021), BRACE20003310 (603899), BRACE20069000 (204200),
BRACE20097540 (604908), BRACE20194670 (314375), BRACE20196180
(605535), BRACE20204670 (176884), BRACE20216950 (158070),
BRAMY20003540 (602142), BRAMY20005080 (604735), BRAMY20035830
(603524), BRAMY20040580 (604077), BRAMY20043630 (602775),
BRAMY20044920 (603486), BRAMY20051820 (604567), BRAMY20056620
(210210), BRAMY20089770 (602566), BRAMY20111780 (604077),
BRAMY20152510 (176879), BRAMY20190550 (600051), BRAMY20221600
(605789), BRAMY20227860 (605416), BRAMY20274510 (180475),
BRAWH20082920 (603246), BRAWH20093040 (602989), BRAWH20095900
(602277), BRAWH20190530 (605208), BRAWH20191980 (239500),
BRCAN10000760 (111000), BRCAN10001050 (603696), BRCAN20005230
(603268), BRSSN20066440 (603430), CTONG20004520 (603817),
CTONG20029030 (602775), CTONG20042640 (103390), CTONG20045500
(106195), CTONG20052780 (605612), CTONG20053990 (602187),
CTONG20070780 (118990), CTONG20070910 (604450), CTONG20072930
(314995), CTONG20083980 (601703), CTONG20084660 (600834),
CTONG20165750 (182465), CTONG20169040 (148030), CTONG20183430
(106410), CTONG20183830 (600382), CTONG20186290 (100660),
CTONG20189000 (600888), DFNES20016470 (605952), DFNES20025500
(604581), DFNES20046840 (602617; 241850), DFNES20055400 (603456),
DFNES20080880 (602273), FCBBF10000230 (602327), FCBBF20035490
(602489), FCBBF20066340 (603560), FCBBF30002270 (142708),
FCBBF30002280 (176763), FCBBF30019140 (602120), FCBBF30053300
(600299), FCBBF30071500 (125485), FCBBF30072440 (604455),
FCBBF30076310 (176892), FCBBF30080730 (600572), FCBBF30100080
(602488), FCBBF30115920 (603577), FCBBF30118670 (603640),
FCBBF30129010 (601260), FCBBF30132050 (603018), FCBBF30136230
(189909), FCBBF30153170 (171860; 171850), FCBBF30164510 (603006),
FCBBF30166220 (182144), FCBBF30171230 (162151), FCBBF30175350
(602521), FCBBF30194550 (182900), FCBBF30220050 (600380),
FCBBF30223210 (300022), FCBBF30263080 (194558), FCBBF30275590
(601403), FCBBF50001650 (605268), FEBRA20027070 (314995),
FEBRA20045380 (602942), FEBRA20046200 (106410), FEBRA20046510
(604077), FEBRA20057010 (602187), FEBRA20063720 (603899),
FEBRA20078800 (601825; 256000), FEBRA20087550 (600811),
FEBRA20088810 (603725), FEBRA20090160 (600137), FEBRA20092760
(602567), FEBRA20170240 (314997), FEBRA20173330 (602990),
FEBRA20191720 (603895), HCHON10000150 (300163), HCHON20015050
(151510), HEART20009590 (604581), HEART20022200 (601870),
HEART20063100 (602422), HHDPC20081230 (164035), HLUNG20008460
(300108), HLUNG20014590 (604077), HLUNG20032460 (176785),
HLUNG20063700 (600210), HLUNG20065990 (186591), HLUNG20069350
(114212), HLUNG20081530 (162230), HLUNG20082350 (604677),
HLUNG20083330 (120180), HLUNG20085210 (604464), KIDNE20081170
(604535), KIDNE20084040 (602382), KIDNE20088240 (605084),
KIDNE20089870 (602922), KIDNE20133460 (605430), KIDNE20134890
(117143), KIDNE20141700 (312760), KIDNE20142900 (188040),
KIDNE20150730 (179715), KIDNE20152440 (602194), KIDNE20160360
(602488), KIDNE20165390 (604649), KIDNE20169180 (191845),
KIDNE20173430 (603831), KIDNE20189960 (275360), LIVER20026440
(601270), MESAN20006200 (151740), MESAN20021130 (600050),
MESAN20033220 (600466), MESAN20056890 (600813), MESAN20057240
(126380), MESAN20065990 (601959), MESAN20067430 (191010),
MESAN20069530 (604362), NESOP20004520 (153432), NT2NE20018890
(606031), NT2NE20026200 (277730), NT2NE20037050 (300028),
NT2NE20053950 (604078), NT2NE20061030 (600834), NT2NE20111190
(602619), NT2NE20117580 (601825; 256000), NT2NE20119980 (191161),
NT2NE20140130 (601281), NT2NE20141040 (602917), NT2RI20093010
(172460), NT2RP70003110 (130160; 194050), NT2RP70046410 (601930),
NT2RP70075300 (601856), NTONG20032100 (148065; 193900),
NTONG20034540 (602658), OCBBF20000740 (602059), OCBBF20012520
(602059), OCBBF20111600 (147625), OCBBF20120010 (605008),
OCBBF20156450 (314997), OCBBF20157970 (604077), OCBBF20191950
(192977), PEBLM20001800 (146900), PEBLM20003260 (194558),
PLACE60004260 (601891), PLACE60012620 (214500), PLACE60054230
(300108), PLACE60054870 (160776), PLACE60062660 (606004),
PLACE60087680 (146732), PLACE60184870 (172425), PROST20015210
(160745), PROST20024250 (604078), PROST20036350 (138295),
PROST20050390 (601258), PROST20058860 (182282), PROST20063430
(603292), PROST20065790 (171840), PROST20084720 (604426),
PROST20099090 (602714), PROST20120070 (602809), PROST20127450
(602960), PROST20146590 (158340; 113720), PROST20152510 (603367),
PROST20168600 (604415), PUAEN10000650 (602960), PUAEN20003120
(601573), SKMUS20008730 (602127), SKMUS20017400 (191030),
SKMUS20040440 (604163), SKMUS20073590 (605834), SKMUS20079150
(605596), SKNSH20009710 (191030; 164970), SMINT20002320 (601644),
SMINT20007470 (190370), SMINT20008110 (604384), SMINT20011950
(603430), SMINT20016150 (134790), SMINT20026200 (159556),
SMINT20030740 (604078), SMINT20049920 (600417), SMINT20077960
(137350; 105120), SMINT20083290 (146900), SMINT20086250 (238330),
SMINT20089600 (605926), SMINT20091190 (146900), SPLEN20023540
(605577), SPLEN20024190 (601548), SPLEN20042200 (604167),
SPLEN20043680 (126340; 234050; 278730), SPLEN20055600 (194541),
SPLEN20057830 (179715), SPLEN20059270 (602165), SPLEN20063890
(600245), SPLEN20073500 (603300), SPLEN20080070 (230000),
SPLEN20085910 (603424), SPLEN20090880 (142800), SPLEN20098030
(601742), SPLEN20118050 (301870), SPLEN20136730 (605412),
SPLEN20138600 (603728), SPLEN20139100 (147120), SPLEN20139360
(117140), SPLEN20180980 (156560), SPLEN20187490 (179838),
SPLEN20193790 (147150), SPLEN20201830 (301870), TESTI10000190
(158340; 113720), TESTI20031310 (107280), TESTI20035790 (601940),
TESTI20049060 (603889), TESTI20050720 (245050), TESTI20051200
(602273), TESTI20057430 (194532), TESTI20057590 (601890),
TESTI20059080 (604038), TESTI20062120 (604212), TESTI20067480
(602277), TESTI20071630 (602692), TESTI20099350 (160776),
TESTI20105130 (310400), TESTI20105910 (601328), TESTI20108060
(600590), TESTI20125920 (601934), TESTI20130530 (146680),
TESTI20131440 (114850), TESTI20134680 (117143), TESTI20142540
(137960), TESTI20143180 (117143), TESTI20150420 (602732),
TESTI20154370 (600936), TESTI20164210 (602319), TESTI20166670
(142968), TESTI20168880 (151410), TESTI20171070 (604064),
TESTI20182760 (601328), TESTI20184750 (150320), TESTI20193080
(602128), TESTI20194880 (602260), TESTI20196970 (601117),
TESTI20197600 (604167), TESTI20201760 (602162), TESTI20207170
(480100), TESTI20219110 (601890), TESTI20228740 (604077),
TESTI20244430 (182900), TESTI20246480 (601486), TESTI20251740
(602731), TESTI20252690 (601368), TESTI20254030 (602330),
TESTI20257910 (142871), TESTI20258720 (182900), TESTI20266050
(109092), TESTI20271790 (604678), TESTI20274960 (194558),
TESTI20282530 (604077), TESTI20286590 (147267), THYMU10004280
(602290), THYMU20006020 (601149), THYMU20013250 (601988),
THYMU20019260 (603899), THYMU20023560 (142765), THYMU20028150
(190197), THYMU20032820 (604077), THYMU20034400 (604449),
THYMU20055460 (133280), THYMU20063650 (180480), THYMU20070250
(277730), THYMU20071120 (603899), THYMU20081110 (602567),
THYMU20090230 (602324), THYMU20095920 (605349), THYMU20098350
(148040; 131760; 131800; 131900), THYMU20099060 (146900),
THYMU20120730 (100660), THYMU20121040 (130592), THYMU20170080
(604964), THYMU20185650 (602121; 124900), THYMU20191970 (604265),
TKIDN10000620 (605072), TKIDN10001920 (603899), TRACH20011540
(191155), TRACH20091070 (100660), TRACH20143710 (601905),
TRACH20170860 (147170), UTERU10001060 (311040), UTERU20026620
(314997), UTERU20041630 (602277), UTERU20086530 (173310),
UTERU20087070 (216950), UTERU20087850 (605248), UTERU20099510
(604077), UTERU20101150 (164012), UTERU20104310 (604414),
UTERU20127030 (150325), UTERU20185220 (600014)
[1422] The clones predicted to belong to the category of enzyme
and/or metabolism-related protein are the following 219 clones.
TABLE-US-00037 ADRGL20059610, ASTRO20026320, ASTRO20050810,
ASTRO20088950, BNGH420008150, BNGH420035290, BNGH420074600,
BRACE20050870, BRACE20097540, BRACE20200770, BRACE20204670,
BRACE20215410, BRAMY20003540, BRAMY20005080, BRAMY20027990,
BRAMY20028620, BRAMY20044920, BRAMY20055760, BRAMY20056620,
BRAMY20072870, BRAMY20093490, BRAMY20096930, BRAMY20118490,
BRAMY20125360, BRAMY20143870, BRAMY20152510, BRAMY20231150,
BRAMY20244490, BRAMY20251210, BRAWH20021910, BRAWH20082920,
BRAWH20093040, BRAWH20094900, BRAWH20183170, BRAWH20188750,
BRAWH20190550, BRAWH20191980, BRCAN20005230, BRCOC20003600,
CTONG20051100, CTONG20070910, CTONG20076810, CTONG20079590,
CTONG20080140, CTONG20085210, CTONG20186290, DFNES20063460,
DFNES20080880, FCBBF20023490, FCBBF20066340, FCBBF30004340,
FCBBF30019140, FCBBF30022680, FCBBF30029250, FCBBF30072440,
FCBBF30076310, FCBBF30085560, FCBBF30091520, FCBBF30107290,
FCBBF30125880, FCBBF30132050, FCBBF30143550, FCBBF30153170,
FCBBF30166220, FCBBF30171230, FCBBF30175350, FCBBF30236670,
FCBBF30260480, FEBRA20038220, FEBRA20040560, FEBRA20078800,
FEBRA20090160, FEBRA20172230, FEBRA20173330, HCHON20000870,
HCHON20002710, HEART10001490, HEART20022200, HEART20047640,
HEART20082570, HLUNG20011260, HLUNG20032460, HLUNG20041540,
HLUNG20042730, HLUNG20054790, KIDNE20080690, KIDNE20083620,
KIDNE20084040, KIDNE20147170, KIDNE20152440, KIDNE20173150,
KIDNE20186170, KIDNE20189960, LIVER20011640, LIVER20026440,
LIVER20055270, MESAN20021130, MESAN20033220, MESAN20038520,
MESAN20057240, MESAN20058110, MESAN20065990, MESAN20095800,
NT2NE20026200, NT2NE20042550, NT2NE20117580, NT2NE20127900,
NT2RI20093010, NT2RP70064570, NTONG20034540, NTONG20043080,
NTONG20053630, NTONG20053730, NTONG20058010, OCBBF20120010,
OCBBF20167290, OCBBF20191950, PANCR10000860, PLACE60052940,
PLACE60064180, PLACE60073090, PLACE60095600, PLACE60184410,
PLACE60188630, PROST20007600, PROST20033240, PROST20036350,
PROST20039300, PROST20050390, PROST20051310, PROST20052850,
PROST20065790, PROST20075280, PROST20084720, PROST20099090,
PROST20108850, PROST20152510, PUAEN20001520, PUAEN20002470,
SKNMC20006350, SKNSH20057920, SMINT20008110, SMINT20049920,
SMINT20094680, SPLEN20023540, SPLEN20024930, SPLEN20043680,
SPLEN20048800, SPLEN20054500, SPLEN20057900, SPLEN20071820,
SPLEN20080070, SPLEN20085910, SPLEN20108000, SPLEN20136730,
SPLEN20180980, TESTI20012080, TESTI20030200, TESTI20031310,
TESTI20038240, TESTI20050720, TESTI20051200, TESTI20059080,
TESTI20062120, TESTI20066330, TESTI20076570, TESTI20103690,
TESTI20105130, TESTI20106820, TESTI20108060, TESTI20112860,
TESTI20121040, TESTI20130530, TESTI20131440, TESTI20168880,
TESTI20170170, TESTI20196690, TESTI20196970, TESTI20199110,
TESTI20205250, TESTI20212970, TESTI20222030, TESTI20226520,
TESTI20227380, TESTI20244460, TESTI20244730, TESTI20250630,
TESTI20260640, TESTI20262940, TESTI20264530, TESTI20285230,
THYMU20006020, THYMU20013250, THYMU20034400, THYMU20039320,
THYMU20055460, THYMU20055760, THYMU20063650, THYMU20066660,
THYMU20070250, THYMU20087270, THYMU20096580, THYMU20100940,
THYMU20110720, THYMU20120240, THYMU20120730, THYMU20170230,
TRACH20011010, TRACH20021380, TRACH20091070, TRACH20113020,
TRACH20143710, TRACH20164100, TRACH20190460, UTERU20087070,
UTERU20089620, UTERU20104310, UTERU20185220, UTERU20188670
[1423] The clones predicted to belong to the category of cell
division and/or cell proliferation-related protein are the
following 44 clones. TABLE-US-00038 ASTRO20090680, BRACE20079370,
BRAMY20234820, BRCAN10001050, BRCAN20005410, CTONG20032930,
FCBBF20070950, FCBBF30002270, FCBBF30053300, FCBBF30105860,
FCBBF30175350, FCBBF30215240, FCBBF30275590, FEBRA20045380,
HLUNG20068120, KIDNE20134890, KIDNE20150730, MESAN20021470,
NT2NE20077250, NT2NE20153620, NT2RP70030840, NTONG20053910,
OCBBF20111370, OCBBF20174580, PROST20063430, SKNMC10001230,
SMINT20028800, SPLEN20023540, SPLEN20057830, SPLEN20139360,
TESTI20031410, TESTI20057840, TESTI20065650, TESTI20066650,
TESTI20107320, TESTI20108060, TESTI20114480, TESTI20134680,
TESTI20143180, TESTI20150920, TESTI20201760, TESTI20278280,
TESTI20284260, THYMU20097920
[1424] The clones predicted to belong to the category of
cytoskeleton-related protein are the following 80 clones.
TABLE-US-00039 ADRGL20062330, ASTRO20053430, BGGI120000670,
BRACE20079370, BRAMY20038980, BRAMY20083330, BRAMY20094890,
CTONG20004110, CTONG20032930, CTONG20077760, CTONG20083980,
CTONG20169040, CTONG20183430, DFNES20018000, FCBBF30105860,
FCBBF30130410, FCBBF30194550, FCBBF30201630, FCBBF30271990,
FEBRA20005040, FEBRA20046200, FEBRA20099860, HCHON20015050,
HLUNG20081530, KIDNE20081170, NT2RP70001730, NT2RP70003110,
NTONG20032100, OCBBF20166890, OCBBF20174890, PLACE60054870,
PLACE60055590, PLACE60071800, PLACE60118810, PROST20015210,
PROST20097840, PROST20120070, PROST20146590, SKMUS20007260,
SKMUS20008730, SKMUS20017400, SKMUS20073590, SMINT20062050,
SMINT20074330, SMINT20077960, SPLEN20039180, SPLEN20049840,
SPLEN20076470, SPLEN20182990, SPLEN20187490, SPLEN20195710,
TESTI10000190, TESTI20041630, TESTI20057880, TESTI20058920,
TESTI20060080, TESTI20064530, TESTI20064650, TESTI20065650,
TESTI20067440, TESTI20071130, TESTI20099350, TESTI20112540,
TESTI20125280, TESTI20136010, TESTI20153310, TESTI20175370,
TESTI20222460, TESTI20244430, TESTI20254030, TESTI20258720,
THYMU20024500, THYMU20062610, THYMU20098350, TRACH20043360,
TRACH20098510, TRACH20149500, UTERU20089390, UTERU20122520,
UTERU20168960
[1425] The clones predicted to belong to the category of nuclear
protein and/or RNA synthesis-related protein are the following 70
clones. TABLE-US-00040 ASTRO20026320, BRACE20050870, BRACE20200770,
BRAMY20134050, BRAWH20063010, BRAWH20093040, BRAWH20174330,
BRAWH20176850, CTONG20042640, FCBBF20023490, FCBBF20035490,
FCBBF20070950, FCBBF30002270, FCBBF30048420, FCBBF30080730,
FCBBF30115920, FCBBF30236670, FEBRA20035240, FEBRA20092760,
FEBRA20173330, HHDPC20081230, HLUNG20011460, HLUNG20068120,
KIDNE20089870, KIDNE20150730, MESAN20056890, MESAN20057240,
NT2NE20037050, NT2NE20167660, NT2RP70031070, NTONG20053730,
PLACE60064180, PLACE60095600, PROST20016760, PROST20051310,
PROST20058860, PROST20152510, PUAEN20002470, SKMUS20079150,
SKNSH20030640, SPLEN20023850, SPLEN20057830, SPLEN20139360,
SPLEN20190430, TESTI20006830, TESTI20030200, TESTI20031410,
TESTI20035790, TESTI20062120, TESTI20065650, TESTI20081890,
TESTI20150920, TESTI20153310, TESTI20201760, TESTI20212970,
TESTI20227380, TESTI20251740, TESTI20256560, TESTI20260640,
TESTI20270130, TESTI20284260, TESTI20285230, THYMU20021090,
THYMU20049060, THYMU20066660, THYMU20081110, THYMU20090230,
THYMU20120240, UTERU10001060, UTERU20104310
[1426] The clones predicted to belong to the category of protein
synthesis and/or transport-related protein are the following 20
clones. TABLE-US-00041 BRAMY20038980, BRAMY20274510, CTONG20008190,
CTONG20033610, FCBBF20018680, FEBRA20090220, KIDNE20141700,
NT2NE20167660, NTONG20055200, PLACE60012620, PROST20036350,
PROST20062820, SKMUS20040440, SMINT20000070, SPLEN20180980,
TESTI20055680, TESTI20067440, TESTI20107240, THYMU20096580,
THYMU20121040
[1427] The clones predicted to belong to the category of cellular
defense-related protein are the following 10 clones. TABLE-US-00042
ASTRO20089600, BRAMY20117670, FEBRA20087550, HLUNG20081390,
MESAN20057240, NTONG20031580, PROST20007600, SPLEN20023850,
SPLEN20043680, TESTI20261680
[1428] The clones predicted to belong to the category of
development and/or differentiation-related protein are the
following 19 clones. TABLE-US-00043 BRACE20061620, BRACE20200770,
BRAMY20013670, CTONG20017490, CTONG20020950, HCHON10000150,
MESAN20021470, OCBBF20165910, PROST20155370, PUAEN20002470,
TESTI20079220, TESTI20079980, TESTI20166670, TESTI20184760,
TESTI20252690, TRACH20040390, UTERU20089620, UTERU20094830,
UTERU20169020
[1429] The clones predicted to belong to the category of
DNA-binding and/or RNA-binding protein are the following 168
clones. TABLE-US-00044 ASTRO20038400, BGGI120010750, BNGH420070370,
BRACE20003310, BRACE20061620, BRAMY20001510, BRAMY20040580,
BRAMY20076100, BRAMY20111780, BRAMY20274510, BRAWH20040680,
BRAWH20050740, BRAWH20063010, BRAWH20080580, BRAWH20095900,
BRAWH20174330, BRSSN20066440, CTONG20020950, CTONG20044230,
CTONG20053990, CTONG20072930, CTONG20074000, CTONG20165750,
CTONG20186370, CTONG20186520, DFNES20046840, DFNES20073320,
FCBBF20035430, FCBBF20070950, FCBBF30002270, FCBBF30003610,
FCBBF30019140, FCBBF30021900, FCBBF30048420, FCBBF30080730,
FCBBF30093170, FCBBF30114850, FCBBF30129010, FCBBF30136230,
FCBBF30220050, FCBBF30228940, FCBBF30236670, FCBBF30263080,
FCBBF30285930, FCBBF50003530, FEBRA20026820, FEBRA20027070,
FEBRA20035240, FEBRA20046510, FEBRA20057010, FEBRA20063720,
FEBRA20087550, FEBRA20092760, FEBRA20170240, FEBRA20177800,
HCHON20002650, HEART20019310, HEART20063100, HHDPC20081230,
HLUNG20011460, HLUNG20014590, HLUNG20028110, HLUNG20063700,
HLUNG20068120, KIDNE20140870, LIVER20006260, MESAN20016270,
MESAN20056890, MESAN20057240, NT2NE20038870, NT2NE20053950,
NT2NE20060750, NT2NE20079670, NT2NE20082600, NT2NE20087270,
NT2RP70029780, NT2RP70046410, NT2RP70057500, NT2RP70075300,
NT2RP70090870, OCBBF20116250, OCBBF20120950, OCBBF20121910,
OCBBF20156450, OCBBF20157970, OCBBF20166900, OCBBF20175360,
OCBBF20177540, PEBLM10001470, PEBLM20003260, PLACE60066970,
PLACE60122970, PLACE60177880, PROST20007170, PROST20024250,
PROST20035170, PROST20051310, PROST20058860, PROST20151370,
PROST20155370, PUAEN20003120, SMINT20011950, SMINT20030740,
SMINT20039050, SMINT20044140, SMINT20086720, SPLEN20042200,
SPLEN20043680, SPLEN20055600, SPLEN20059270, SPLEN20063250,
SPLEN20139360, SPLEN20190430, TESTI10001570, TESTI20006830,
TESTI20030200, TESTI20031410, TESTI20035790, TESTI20057430,
TESTI20059810, TESTI20062120, TESTI20067480, TESTI20068790,
TESTI20075240, TESTI20079220, TESTI20088840, TESTI20104090,
TESTI20134970, TESTI20166670, TESTI20171070, TESTI20173960,
TESTI20184760, TESTI20197600, TESTI20201760, TESTI20212970,
TESTI20227380, TESTI20228740, TESTI20246480, TESTI20254030,
TESTI20254990, TESTI20266050, TESTI20268240, TESTI20270130,
TESTI20274960, TESTI20282530, TESTI20284260, TESTI20285230,
THYMU10004280, THYMU20019260, THYMU20023560, THYMU20032820,
THYMU20049060, THYMU20066660, THYMU20071120, THYMU20077250,
THYMU20081110, THYMU20090230, TKIDN10001920, TRACH20108240,
UTERU10001060, UTERU20026620, UTERU20041630, UTERU20094830,
UTERU20099510, UTERU20101150, UTERU20169020, UTERU20177150,
UTERU20188670
[1430] The clones predicted to belong to the category of ATP
binding and/or GTP-binding protein are the following 93 clones.
TABLE-US-00045 ASTRO20026320, BNGH420035290, BRACE20050870,
BRACE20079370, BRACE20200770, BRAMY20055760, BRAMY20118490,
BRAMY20244490, BRAMY20251210, BRAWH20093040, BRAWH20190550,
BRCAN10001050, BRCOC20003600, CTONG20008190, CTONG20030280,
CTONG20032930, CTONG20176040, CTONG20184830, FCBBF20023490,
FCBBF30019140, FCBBF30076310, FCBBF30105860, FCBBF30175350,
FCBBF30201630, FCBBF30236670, FEBRA20005040, FEBRA20090160,
FEBRA20173330, HCHON20000870, HLUNG20011260, HLUNG20052300,
KIDNE20081170, KIDNE20134890, LIVER20030650, LIVER20055270,
MESAN20065990, NT2NE20042550, NTONG20043080, NTONG20055200,
OCBBF20182060, PLACE60054870, PLACE60064180, PLACE60095600,
PLACE60140640, PROST20015210, PROST20033240, PROST20036350,
PROST20051310, PROST20052850, PROST20062820, PROST20075280,
PROST20120070, PUAEN20002470, SKNSH20052400, SKNSH20057920,
SMINT20008110, SPLEN20023850, SPLEN20043680, SPLEN20049840,
SPLEN20136730, SPLEN20180980, SPLEN20193790, TESTI20055680,
TESTI20058920, TESTI20060080, TESTI20064650, TESTI20071130,
TESTI20099350, TESTI20106820, TESTI20112860, TESTI20134680,
TESTI20136010, TESTI20143180, TESTI20175370, TESTI20212970,
TESTI20222460, TESTI20227380, TESTI20244220, TESTI20244460,
TESTI20264530, THYMU20013250, THYMU20039320, THYMU20062610,
THYMU20066660, THYMU20087270, THYMU20096580, THYMU20100940,
THYMU20176010, TRACH20043360, TRACH20098510, TRACH20113020,
UTERU20185220, UTERU20188670
[1431] Among the clones other than the ones shown above,
BNGH420036410 and FCBBF30257370 are clones which were predicted to
highly possibly belong to the category of secretory protein and/or
membrane protein based on the result of domain search by Pfam.
SMINT20044730, TESTI20140970
[1432] The two clones shown above are clones which were predicted
to highly possibly belong to the category of glycoprotein-related
protein based on the result of domain search by Pfam.
TABLE-US-00046 BRACE20055560, CTONG20046690, DFNES20043710,
FCBBF30005500, MESAN20030350, MESAN20030370, PLACE60074820,
TESTI20058350, TESTI2010E170, TRACH20131230, UTERU20000950
[1433] The 11 clones shown above are clones which were predicted to
highly possibly belong to the category of signal
transduction-related protein based on the result of domain search
by Pfam. TABLE-US-00047 ASTRO20010290, BRACE20099070,
CTONG20007660, DFNES20076340, DFNES20094820, FCBBF30125460,
FCBBF30142290, FCBBF30169280, FEBRA20031000, NT2NE20026510,
NT2RP70031340, PLACE50001390, SPLEN20135030, TESTI20046890,
TESTI20060350, TESTI20166290, TESTI20259110, THYMU20184550
[1434] The 18 clones shown above are clones which were predicted to
highly possibly belong to the category of transcription-related
protein based on the result of domain search by Pfam.
TABLE-US-00048 ADRGL20047770, ADRGL20079060, BRACE20014450,
BRACE20051600, BRAWH20185260, CTONG20033750, CTONG20070090,
CTONG20190290, FCBBF20020440, FCBBF30005360, FCBBF30173960,
FEBRA20031000, KIDNE20087880, LIVER20013890, MESAN20030350,
MESAN20030370, OCBBF20113110, PLACE60074820, PLACE60093380,
PROST20028970, PROST20102190, SALGL10001070, SPLEN20006950,
SPLEN20011350, SPLEN20050090, TESTI20060830, TESTI20066150,
TESTI20120900, TESTI20132310, TESTI20148380, TESTI20162980,
TESTI20166290, TESTI20205100, THYMU20112590, TRACH20029880
[1435] The 35 clones shown above are clones which were predicted to
highly possibly belong to the category of enzyme and/or
metabolism-related protein based on the result of domain search by
Pfam.
PLACE60054820, TESTI20197030
[1436] The two clones shown above are clones which were predicted
to highly possibly belong to the category of cell division and/or
cell proliferation-related protein based on the result of domain
search by Pfam.
ASTRO20006530, OCBBF20016390, TRACH20058000
[1437] The three clones shown above are clones which were predicted
to highly possibly belong to the category of cytoskeleton-related
protein based on the result of domain search by Pfam.
BRACE20065470, PLACE60054820
[1438] The two clones shown above are clones which were predicted
to highly possibly belong to the category of nuclear protein and/or
RNA synthesis-related protein based on the result of domain search
by Pfam. TABLE-US-00049 ASTRO20010290, BRACE20099070,
BRAWH20014590, CTONG20007660, DFNES20076340, DFNES20094820,
FCBBF30125460, FCBBF30142290, FCBBF30169280, FEBRA20031000,
MESAN20034440, NT2NE20026510, NT2RP70031340, PLACE50001390,
SPLEN20135030, TESTI20046890, TESTI20060350, TESTI20166290,
TESTI20259110, THYMU20104480, THYMU20184550
[1439] The 21 clones shown above are clones which were predicted to
highly possibly belong to the category of DNA-binding and/or
RNA-binding protein based on the result of domain search by
Pfam.
KIDNE20133880, MESAN20030350, MESAN20030370, TESTI20059480
[1440] The four clones shown above are clones which were predicted
to highly possibly belong to the category of ATP-binding and/or
GTP-binding protein based on the result of domain search by
Pfam.
[1441] The 205 clones shown below are clones which were
unassignable to any of the above-mentioned categories, but have
been predicted to have some functions based on homology search for
their full-length nucleotide sequences and motif search in their
deduced ORFs. Clone Name, Definition in the result of homology
search or Motif Name in the motif search, demarcated by a double
slash mark (//), are shown below. [1442] ADRGL20022600//DIAPHANOUS
PROTEIN HOMOLOG 1 (P140MDIA). [1443] ADRGL20023920//ABC1 PROTEIN
HOMOLOG PRECURSOR. [1444] ASTRO20001910//Rattus norvegicus mRNA for
annexin V-binding protein (ABP-10), partial cds. [1445]
ASTRO20009140//PUTATIVE COMPETENCE-DAMAGE PROTEIN. [1446]
ASTRO20046280//PSU1 PROTEIN. [1447] ASTRO20058960//DNA damage
inducible protein homolog--fission yeast (Schizosaccharomyces
pombe) [1448] BNGH420024870//C2 domain//C2 domain//C2 domain [1449]
BRACE20007330//RING CANAL PROTEIN (KELCH PROTEIN). [1450]
BRACE20052430//Homo sapiens AMSH mRNA, complete cds. [1451]
BRACE20054600//Xenopus laevis mRNA for Kielin, complete cds. [1452]
BRACE20059810//TSC-22/dip/bun family [1453]
BRACE20063540//MEROZOITE SURFACE PROTEIN CMZ-8 (FRAGMENT). [1454]
BRACE20079200//Xenopus laevis mRNA for Kielin, complete cds. [1455]
BRAMY20016780//Proprotein convertase P-domain [1456]
BRAMY20023640//UBX domain [1457] BRAMY20045420//Domain found in
Dishevelled, Egl-10, and Pleckstrin [1458] BRAMY20056840//UBE-1c2
[1459] BRAMY20063750//Homo sapiens HRIHFB2007 mRNA, partial cds.
[1460] BRAMY20102900//Homo sapiens RU1 (RU1) mRNA, complete cds.
[1461] BRAMY20158550//CALMODULIN. [1462] BRAMY20223010//Mus
musculus leucine-rich glioma-inactivated 1 protein precursor,
(Lgi1) mRNA, complete cds. [1463] BRAMY20238630//TETRATRICOPEPTIDE
REPEAT PROTEIN 4. [1464] BRAMY20245760//Araneus diadematus
fibroin-4 mRNA, partial cds. [1465] BRAWH20047790//HMG (high
mobility group) box [1466] BRSSN20005610//Mus musculus semaphorin
cytoplasmic domain-associated protein 3A (Semcap3) mRNA, complete
cds. [1467] BRSSN20005660//Bacterial type II secretion system
protein [1468] BRSSN20093890//Homo sapiens mRNA for Kelch motif
containing protein, complete cds. [1469]
CTONG20041150//Streptomyces ansochromogenes strain 7100 SanE (sanE)
gene, complete cds. [1470] CTONG20066110//Homo sapiens DEME-6 mRNA,
partial cds. [1471] CTONG20069420//Ribosomal protein S14p/S29e
[1472] CTONG20071040//BETA CRYSTALLIN B2 (BP). [1473]
CTONG20074170//DENN (AEX-3) domain [1474] CTONG20083430//Nuclear
transition protein 2 [1475] CTONG20170940//MYOTROPHIN (V-1 PROTEIN)
(GRANULE CELL DIFFERENTIATION PROTEIN). [1476]
CTONG20174290//TRICHOHYALIN. [1477] CTONG20174580//Homo sapiens
mRNA for vascular Rab-GAP/TBC-containing protein complete cds.
[1478] CTONG20180690//Collagen triple helix repeat (20 copies)
[1479] CTONG20186550//cca3 protein--rat [1480] CTONG20188080//TPR
Domain [1481] FCBBF10004760//Homo sapiens GAP-like protein (N61)
mRNA, complete cds. [1482] FCBBF20033360//RING CANAL PROTEIN (KELCH
PROTEIN). [1483] FCBBF20041380//SAM domain (Sterile alpha motif)
[1484] FCBBF20043730//UBA domain [1485] FCBBF20056580//Mus musculus
NSD1 protein mRNA, complete cds. [1486] FCBBF20059660//TPR Domain
[1487] FCBBF30019180//SERINE/THREONINE PROTEIN PHOSPHATASE 2A, 65
KDA REGULATORY SUBUNIT A, ALPHA ISOFORM (PP2A, SUBUNIT A,
PR65-ALPHA ISOFORM) (PP2A, SUBUNIT A, R1-ALPHA ISOFORM). [1488]
FCBBF30026580//Homo sapiens retinoblastoma-associated protein
RAP140 mRNA, complete cds. [1489] FCBBF30035570//C2 domain [1490]
FCBBF30079770//D-isomer specific 2-hydroxyacid dehydrogenases
[1491] FCBBF30100120//Mus musculus semaphorin cytoplasmic
domain-associated protein 3A (Semcap3) mRNA, complete cds. [1492]
FCBBF30100410//Mus musculus testis-specific Y-encoded-like protein
(Tspyl1) mRNA, complete cds. [1493] FCBBF30118890//Drosophila
melanogaster La related protein (larp) mRNA, partial cds. [1494]
FCBBF30138000//trg protein--rat [1495] FCBBF30157270//Rattus
norvegicus PAPIN mRNA, complete cds. [1496] FCBBF30161780//gag gene
protein p24 (core nucleocapsid protein)//Zinc knuckle [1497]
FCBBF30198670//dof protein--fruit fly (Drosophila melanogaster)
[1498] FCBBF30222910//Mus musculus Rap2 interacting protein 8
(RPIP8) mRNA, complete cds. [1499] FCBBF30255680//Rattus norvegicus
brain specific cortactin-binding protein CBP90 mRNA, partial cds.
[1500] FCBBF30260210//Drosophila melanogaster KISMET-L long isoform
(kis) mRNA, complete cds. [1501] FCBBF30282020//cca3 protein--rat
[1502] FCBBF40000610//late gestation lung 2 protein [Rattus
norvegicus]. [1503] FEBRA20029620//Leucine Rich Repeat//Leucine
Rich Repeat//Leucine Rich Repeat [1504] FEBRA20031150//Homo sapiens
HSKM-B (HSKM-B) mRNA, complete cds. [1505]
FEBRA20038330//Corticotropin-releasing factor family [1506]
FEBRA20038970//Homo sapiens mRNA for stabilin-1 (stab1 gene).
[1507] FEBRA20088610//CELLULAR RETINALDEHYDE-BINDING PROTEIN
(CRALBP). [1508] FEBRA20150420//HYPOTHETICAL 131.5 KDA PROTEIN
CO.sub.2F12.7 IN CHROMOSOME X. [1509] FEBRA20175330//D-isomer
specific 2-hydroxyacid dehydrogenases [1510] HEART10001420//Mus
musculus skm-BOP1 (Bop) mRNA, complete cds. [1511]
HLUNG20024050//Rubredoxin [1512] HLUNG20030420//Mus musculus mRNA
for MAIL, complete cds. [1513] HLUNG20030490//Ambystoma tigrinum
RPE65 protein mRNA, complete cds. [1514] HLUNG20033060//Homo
sapiens GAP-like protein (N61) mRNA, complete cds. [1515]
HLUNG20041590//ubiquitous tetratricopeptide containing protein
RoXaN [Homo sapiens]. [1516] HLUNG20045340//MOB2 PROTEIN (MPS1
BINDER 2). [1517] HLUNG20051330//FHIPEP family [1518]
HLUNG20070410//Dihydropyridine sensitive L-type calcium channel
(Beta subunit) [1519] HLUNG20072100//Gallus gallus Dach2 protein
(Dach2) mRNA, complete cds. [1520] HLUNG20083480//Chicken mRNA for
TSC-22 variant, complete cds, clone SLFEST52. [1521]
KIDNE20027980//SAM domain (Sterile alpha motif) [1522]
KIDNE20084730//Homo sapiens FH1/FH2 domain-containing protein FHOS
(FHOS) mRNA, complete cds. [1523] KIDNE20149780//NG28 [Mus
musculus] [1524] KIDNE20154330//Rattus norvegicus mRNA for multi
PDZ domain protein. [1525] KIDNE20170400//Leucine Rich
Repeat//Leucine Rich Repeat//Leucine Rich Repeat//Protein kinase C
terminal domain//Rubredoxin [1526] KIDNE20189890//Homo sapiens mRNA
for KARP-1-binding protein 2 (KAB2), complete cds. [1527]
LIVER20010760//Homo sapiens C-type lectin-like receptor-1 mRNA,
complete cds. [1528] LIVER20040740//RETINAL-BINDING PROTEIN
(RALBP). [1529] MESAN20009090//Homo sapiens CEGP1 protein (CEGP1),
mRNA [1530] MESAN20026870//PAN domain//TBC domain [1531]
MESAN20090190//CEGP1 protein [Homo sapiens]. [1532]
NT2NE20059680//Homo sapiens integrin cytoplasmic domain associated
protein (Icap-1a) mRNA, complete cds. [1533]
NT2NE20077270//Adenovirus EB1 55K protein/large t-antigen [1534]
NT2NE20087850//ANTER-SPECIFIC PROLINE-RICH PROTEIN APG (PROTEIN
CEX) (FRAGMENT). [1535] NT2NE20095230//Homo sapiens HSKM-B (HSKM-B)
mRNA, complete cds. [1536] NT2NE20108420//KES1 PROTEIN. [1537]
NT2NE20173970//Rattus norvegicus beta-catenin binding protein mRNA,
complete cds. [1538] NT2NE20177210//Leishmania major partial ppg1
gene for proteophosphoglycan. [1539] NT2RP70012830//CALPHOTIN.
[1540] NT2RP70035110//Caenorhabditis elegans UNC-89 (unc-89) gene,
complete cds. [1541] NTONG20002230//Mus musculus RW1 protein mRNA,
complete cds. [1542] NTONG20005310//Ribosomal protein S9/S16 [1543]
NTONG20029850//CALCYPHOSINE (R2D5 ANTIGEN). [1544]
NTONG20035150//RING CANAL PROTEIN (KELCH PROTEIN). [1545]
NTONG20058220//Homo sapiens phosphoprotein pp75 mRNA, partial cds.
[1546] OCBBF20005220//Rattus norvegicus Fos-related antigen mRNA,
complete cds. [1547] OCBBF20011860//Mus musculus epithelial protein
lost in neoplasm-a (Eplin) mRNA, complete cds. [1548]
OCBBF20016810//enhancer of polycomb [Mus musculus] [1549]
OCBBF20147070//DNA polymerase (viral) C-terminal domain [1550]
OCBBF20160380//liver stage antigen LSA-1--Plasmodium falciparum
[1551] OCBBF20177910//Corticotropin-releasing factor family [1552]
PEBLM20005020//Virion host shutoff protein [1553]
PLACE60055460//Homo sapiens leucine-zipper protein FKSG13 (FKSG13)
mRNA, complete cds. [1554] PLACE60068710//SUPPRESSOR PROTEIN SRP40.
[1555] PLACE60080360//mucin [Homo sapiens] [1556]
PLACE60082850//Pathogenesis-related protein Bet v I family [1557]
PLACE60098350//Human hepatocellular carcinoma associated protein
(JCL-1) mRNA, complete cds. [1558] PLACE60105680//Homo sapiens mRNA
for TU12B1-TY, complete cds. [1559] PLACE60119700//Homo sapiens
mRNA for ABP32, complete cds. [1560] PLACE60120280//SER/THR-RICH
PROTEIN T10 IN DGCR REGION. [1561] PLACE60132200//TRICHOHYALIN.
[1562] PLACE60181870//Pentaxin family [1563]
PROST20084470//Plasmodium berghei strain NYU2 merozoite surface
protein-1 mRNA, partial cds. [1564] PROST20087240//gag gene protein
p24 (core nucleocapsid protein) [1565] PROST20122490//Gallus gallus
syndesmos mRNA, complete cds. [1566] PROST20130320//S-100/ICaBP
type calcium binding domain [1567] PROST20152870//Homo sapiens APC2
gene, exon 14. [1568] PUAEN10001640//Mus musculus cerebellar
postnatal development protein-1 (Cpd1) mRNA, partial cds. [1569]
PUAEN20000800//Bleomycin resistance protein [1570]
SMINT20012220//Collagen triple helix repeat (20 copies) [1571]
SMINT20035510//Drosophila melanogaster La related protein (larp)
mRNA, partial cds. [1572] SMINT20036440//Drosophila melanogaster
epsin-like protein mRNA, complete cds. [1573] SMINT20038660//Homo
sapiens HNOEL-iso (HNOEL-iso) mRNA, complete cds. [1574]
SMINT20043390//Ras association (RalGDS/AF-6) domain [1575]
SMINT20048720//Cytochrome P450//Cytochrome P450 [1576]
SMINT20052130//Rattus norvegicus mRNA for gankyrin homologue,
complete cds. [1577] SMINT20054050//ABC1 PROTEIN HOMOLOG PRECURSOR.
[1578] SPLEN20024770//Rattus norvegicus (rsec6) mRNA, complete cds.
[1579] SPLEN20040780//CORNIFIN B (SMALL PROLINE-RICH PROTEIN 1B)
(SPR1B) (SPR1 B). [1580] SPLEN20041810//BC-2 protein [Homo sapiens]
[1581] SPLEN20100040//258.1 KDA PROTEIN C210RF5 (KIAA0933). [1582]
SPLEN20104150//Ribosomal protein L36 [1583] SPLEN20116720//Homo
sapiens misato mRNA, partial cds. [1584] SPLEN20176130//Homo
sapiens mRNA for ALEX1, complete cds. [1585]
SPLEN20181570//TRICHOHYALIN. [1586] TESTI20004310//TRICHOHYALIN.
[1587] TESTI20016970//TPR Domain [1588]
TESTI20030440//TRICHOHYALIN. [1589] TESTI20043180//mouse mRNA for
megakaryocyte potentiating factor, complete cds. [1590]
TESTI20043910//IQ calmodulin-binding motif//IQ calmodulin-binding
motif//IQ calmodulin-binding motif//IQ calmodulin-binding motif//IQ
calmodulin-binding motif [1591] TESTI20044900//Strongylocentrotus
purpuratus radial spokehead mRNA, complete cds. [1592]
TESTI20046110//Extracellular link domain [1593] TESTI20047930//Homo
sapiens NY-REN-2 antigen mRNA, complete cds. [1594]
TEST120049410//Proprotein convertase P-domain [1595]
TESTI20053950//IQ calmodulin-binding motif [1596]
TESTI20054700//Streptococcus pneumoniae strain g375 surface protein
PspC (pspC) gene, pspC-8.1 allele, complete cds. [1597]
TESTI20055880//Serum amyloid A protein [1598] TESTI20056030//Homo
sapiens 88-kDa Golgi protein (GM88) mRNA, complete cds. [1599]
TESTI20061090//Keratin, high sulfur B2 protein [1600]
TESTI20064370//TPR Domain//TPR Domain//TPR Domain//TPR
Domain//Synaptobrevin [1601] TESTI20084250//OXYSTEROL-BINDING
PROTEIN. [1602] TESTI20092170//ENV polyprotein (coat polyprotein)
[1603] TESTI20116050//UBX domain [1604] TESTI20120500//Kelch
motif//Kelch motif [1605] TESTI20126280//Mus musculus STAP mRNA for
sperm tail associated protein, complete cds. [1606]
TESTI20144390//TESTIS-SPECIFIC PROTEIN PBS13. [1607]
TESTI20165990//Ribosomal protein L36 [1608]
TESTI20169500//HYPOTHETICAL 51.9 KDA PROTEIN C27F1.04C IN
CHROMOSOME I. [1609] TESTI20170280//Flagellar L-ring protein [1610]
TESTI20176450//thioredoxin interacting factor [Mus musculus].
[1611] TESTI20179230//Dihydropyridine sensitive L-type calcium
channel (Beta subunit) [1612] TESTI20180600//Homo sapiens
HOM-TES-85 tumor antigen mRNA, complete cds. [1613]
TESTI20209050//HYPOTHETICAL 113.1 KDA PROTEIN IN PRE5-FET4
INTERGENIC REGION. [1614] TESTI20210570//RETINAL-BINDING PROTEIN
(RALBP). [1615] TESTI20215310//Homo sapiens calcyclin binding
protein mRNA, complete cds. [1616] TESTI20247440//Human BLu protein
testis isoform (BLu) mRNA, complete cds. [1617] TESTI20249360//Homo
sapiens DEME-6 mRNA, partial cds. [1618]
TESTI20250220//TRICHOHYALIN. [1619] TESTI20251440//Rattus
norvegicus (rsec6) mRNA, complete cds. [1620] TESTI20255460//Mus
musculus mRNA for MIWI (piwi), complete cds. [1621]
THYMU20009500//TPR Domain [1622] THYMU20010180//MOB1 PROTEIN (MPS1
BINDER 1). [1623] THYMU20013810//Human SEC7 homolog Tic (TIC) mRNA,
complete cds. [1624] THYMU20018250//TPR Domain [1625]
THYMU20026950//Mus musculus ROSA 26 transcription AS ROSA26AS mRNA,
complete cds. [1626] THYMU20028410//Mus musculus Pax transcription
activation domain interacting protein PTIP mRNA, complete cds.
[1627] THYMU20030460//Homo sapiens tumor endothelial marker 7
precursor (TEM7) mRNA, complete cds. [1628] THYMU20031330//Homo
sapiens putative nucleotide binding protein mRNA, complete cds.
[1629] THYMU20052460//PHORBOLIN I (FRAGMENTS). [1630]
THYMU20055450//Zona pellucida-like domain [1631]
THYMU20083830//Homo sapiens angiostatin binding protein 1 mRNA,
complete cds. [1632] THYMU20139160//Uncharacterized protein family
UPF0031 [1633] THYMU20151610//Homo sapiens antigen NY-CO-1
(NY-CO-1) mRNA, complete cds. [1634] TRACH20093400//TRICHOHYALIN.
[1635] TRACH20104510//Uncharacterized protein family UPF0005 [1636]
TRACH20122980//HYPOTHETICAL PROTEIN MJ0798. [1637]
TRACH20139280//PX domain [1638] TRACH20164810//D-isomer specific
2-hydroxyacid dehydrogenases [1639] TRACH20165540//Human alpha-1
type I collagen gene surrounding osteogenesis imperfecta OI type II
deletion. [1640] UTERU20051790//guanylate kinase-interacting
protein 1 Maguin-1, membrane-associated--rat [1641]
UTERU20083020//Domain of unknown function DUF71 [1642]
UTERU20121140//Rhodanese-like domain [1643] UTERU20128560//26.4 KDA
PROTEIN IN RUVC-ASPS INTERGENIC REGION. [1644]
UTERU20132620//AXONEME-ASSOCIATED PROTEIN MST101 (2). [1645]
UTERU20134830//pellino (Drosophila) homolog 2 [Homo sapiens] [1646]
UTERU20181270//Zinc knuckle
[1647] With respect to the remaining 613 clones, there are so far
no information available for estimating their functions. However,
there is the possibility that the functions of these clones will be
revealed in future. Their Clone Names are indicated below.
TABLE-US-00050 ADRGL20027530, ADRGL20040310, ADRGL20040770,
ADRGL20046760, ADRGL20047080, ADRGL20057560, ADRGL20067320,
ADRGL20095330, ASTRO20003720, ASTRO20004820, ASTRO20012270,
ASTRO20020350, ASTRO20022020, ASTRO20027330, ASTRO20047510,
ASTRO20069200, ASTRO20076660, ASTRO20091770, ASTRO20141740,
BNGH410000570, BNGH420014060, BNGH420040760, BNGH420042910,
BNGH420045380, BNGH420061350, BNGH420062340, BNGH420085100,
BRACE20009050, BRACE20017790, BRACE20018810, BRACE20025820,
BRACE20038920, BRACE20054480, BRACE20057870, BRACE20059110,
BRACE20062580, BRACE20069440, BRACE20098860, BRACE20196960,
BRACE20200970, BRACE20205840, BRACE20207420, BRACE20212450,
BRACE20216700, BRACE20219360, BRAMY10000980, BRAMY20000210,
BRAMY20000250, BRAMY20020440, BRAMY20021580, BRAMY20023390,
BRAMY20036530, BRAMY20036810, BRAMY20039290, BRAMY20043520,
BRAMY20050640, BRAMY20052440, BRAMY20073080, BRAMY20074110,
BRAMY20074860, BRAMY20076130, BRAMY20076530, BRAMY20095080,
BRAMY20095570, BRAMY20100680, BRAMY20107980, BRAMY20120170,
BRAMY20124970, BRAMY20125170, BRAMY20126910, BRAMY20139750,
BRAMY20155500, BRAMY20159250, BRAMY20160020, BRAMY20173480,
BRAMY20219620, BRAMY20225250, BRAMY20227230, BRAMY20227960,
BRAMY20243120, BRAMY20245350, BRAMY20267780, BRAMY20269040,
BRAMY20271140, BRAMY20287400, BRAWH20020600, BRAWH20025490,
BRAWH20027250, BRAWH20055240, BRAWH20055780, BRAWH20058120,
BRAWH20078080, BRAWH20082550, BRAWH20173790, BRAWH20175230,
BRAWH20175340, BRAWH20182670, BRAWH20186010, BRCOC10000400,
BRHIP20003590, BRHIP20005060, BRSSN20092440, CTONG10000090,
CTONG20000340, CTONG20002790, CTONG20008460, CTONG20015240,
CTONG20020660, CTONG20027660, CTONG20031150, CTONG20031890,
CTONG20033500, CTONG20035240, CTONG20036800, CTONG20039370,
CTONG20050490, CTONG20055670, CTONG20057750, CTONG20057950,
CTONG20061290, CTONG20062730, CTONG20065240, CTONG20073990,
CTONG20074740, CTONG20076230, CTONG20081840, CTONG20133720,
CTONG20165590, CTONG20166580, CTONG20168460, CTONG20169530,
CTONG20174440, CTONG20179390, CTONG20179980, CTONG20180620,
CTONG20181350, CTONG20184130, CTONG20186140, CTONG20190630,
DFNES20032550, DFNES20088810, FCBBF10002200, FCBBF20021110,
FCBBF20028980, FCBBF20038230, FCBBF20038950, FCBBF20061310,
FCBBF20070800, FCBBF30000010, FCBBF30001020, FCBBF30001150,
FCBBF30002330, FCBBF30004730, FCBBF30005180, FCBBF30019240,
FCBBF30056980, FCBBF30063990, FCBBF30068210, FCBBF30072480,
FCBBF30074530, FCBBF30074620, FCBBF30081000, FCBBF30088700,
FCBBF30089380, FCBBF30091010, FCBBF30099490, FCBBF30101240,
FCBBF30101300, FCBBF30105080, FCBBF30106950, FCBBF30107330,
FCBBF30114180, FCBBF30115230, FCBBF30128420, FCBBF30130580,
FCBBF30151190, FCBBF30170710, FCBBF30179180, FCBBF30181730,
FCBBF30194370, FCBBF30195700, FCBBF40001920, FCBBF40005000,
FCBBF50000410, FEBRA20035200, FEBRA20039070, FEBRA20040260,
FEBRA20040290, FEBRA20076200, FEBRA20078180, FEBRA20082660,
FEBRA20083410, FEBRA20086600, FEBRA20091620, FEBRA20093270,
FEBRA20093280, FEBRA20095410, FEBRA20098040, FEBRA20101410,
FEBRA20108020, FEBRA20108580, FEBRA20121200, FEBRA20163980,
FEBRA20175020, FEBRA20180510, FEBRA20187460, HHDPC20082970,
HLUNG20009260, HLUNG20009550, HLUNG20010130, HLUNG20011440,
HLUNG20012140, HLUNG20020500, HLUNG20021450, HLUNG20023030,
HLUNG20025620, HLUNG20029420, HLUNG20030610, HLUNG20031620,
HLUNG20033310, HLUNG20037140, HLUNG20037780, HLUNG20038330,
HLUNG20047070, HLUNG20055240, HLUNG20056560, HLUNG20057380,
HLUNG20059240, HLUNG20065700, HLUNG20067810, HLUNG20072190,
HLUNG20072450, HLUNG20079310, HLUNG20083840, HLUNG20083960,
HLUNG20093030, HLUNG20094130, KIDNE20011600, KIDNE20024380,
KIDNE20086970, KIDNE20091090, KIDNE20094260, KIDNE20095530,
KIDNE20137310, KIDNE20138450, KIDNE20141120, KIDNE20142680,
KIDNE20154830, KIDNE20155980, KIDNE20157100, KIDNE20176030,
KIDNE20181670, KIDNE20191870, LIVER20007690, LIVER20032340,
MESAN20008940, MESAN20021860, MESAN20029780, MESAN20030390,
MESAN20041380, MESAN20045750, MESAN20060220, MESAN20085360,
MESAN20089260, MESAN20094180, NESOP20005040, NT2NE20028700,
NT2NE20033150, NT2NE20045190, NT2NE20047870, NT2NE20062880,
NT2NE20066590, NT2NE20070520, NT2NE20073650, NT2NE20077860,
NT2NE20086070, NT2NE20088030, NT2NE20104000, NT2NE20107810,
NT2NE20112210, NT2NE20114850, NT2NE20123610, NT2NE20124570,
NT2NE20126030, NT2NE20140280, NT2NE20148690, NT2NE20149500,
NT2NE20150610, NT2NE20157120, NT2NE20165190, NT2NE20181760,
NT2NE20184720, NT2RP70022820, NT2RP70049610, NT2RP70056290,
NT2RP70074800, NT2RP70080150, NT2RP70084540, NTONG20017620,
NTONG20049180, OCBBF20001780, OCBBF20009820, OCBBF20109450,
OCBBF20112320, OCBBF20115360, OCBBF20117220, OCBBF20119810,
OCBBF20142290, OCBBF20152330, OCBBF20188280, PLACE60001910,
PLACE60011180, PLACE60017120, PLACE60055350, PLACE60062870,
PLACE60063940, PLACE60069880, PLACE60072390, PLACE60072420,
PLACE60077870, PLACE60081260, PLACE60088240, PLACE60092280,
PLACE60092370, PLACE60095240, PLACE60109910, PLACE60132320,
PLACE60132880, PLACE60155910, PLACE60157310, PLACE60162100,
PLACE60175640, PLACE60177910, PROST10001360, PROST10002150,
PROST20011800, PROST20014140, PROST20014650, PROST20015400,
PROST20022120, PROST20036280, PROST20041460, PROST20042700,
PROST20047440, PROST20048170, PROST20052720, PROST20054660,
PROST20060200, PROST20078710, PROST20093470, PROST20094000,
PROST20097310, PROST20097360, PROST20102500, PROST20103820,
PROST20121570, PROST20124000, PROST20125420, PROST20138730,
PROST20156360, PROST20159320, SKMUS20026340, SKMUS20064810,
SKNSH10001010, SKNSH20007160, SKNSH20040390, SKNSH20068220,
SMINT20011830, SMINT20013970, SMINT20014610, SMINT20017310,
SMINT20021260, SNINT20023110, SMINT20031280, SMINT20045830,
SMINT20045890, SMINT20047290, SMINT20056240, SMINT20067080,
SMINT20070620, SMINT20077920, SMINT20084910, SMINT20085310,
SMINT20085450, SMINT20089210, SMINT20092120, SMINT20093630,
SMINT20094150, SPLEN20005160, SPLEN20005370, SPLEN20012450,
SPLEN20015030, SPLEN20016500, SPLEN20019120, SPLEN20020530,
SPLEN20023430, SPLEN20024510, SPLEN20029170, SPLEN20036780,
SPLEN20043430, SPLEN20043460, SPLEN20045550, SPLEN20051420,
SPLEN20062830, SPLEN20067010, SPLEN20076190, SPLEN20081640,
SPLEN20087370, SPLEN20087860, SPLEN20108460, SPLEN20110210,
SPLEN20111450, SPLEN20114190, SPLEN20117580, SPLEN20126110,
SPLEN20137530, SPLEN20192570, SPLEN20193750, SPLEN20197090,
SPLEN20197740, SPLEN20199850, SPLEN20200076, SPLEN20200340,
SPLEN20203590, SPLEN20205120, TESOP10001600, TESTI10000850,
TESTI20005980, TESTI20012360, TESTI20019590, TESTI20028020,
TESTI20030610, TESTI20034750, TESTI20035330, TESTI20040850,
TESTI20045740, TESTI20049990, TESTI20050170, TESTI20052670,
TESTI20053800, TESTI20059330, TESTI20059370, TESTI20059790,
TESTI20060150, TESTI20060450, TESTI20062180, TESTI20062580,
TESTI20064990, TESTI20066170, TESTI20066280, TESTI20066590,
TESTI20067350, TESTI20068940, TESTI20076920, TESTI20079060,
TESTI20080460, TESTI20083890, TESTI20085670, TESTI20089290,
TESTI20090180, TESTI20090970, TESTI20091360, TESTI20093900,
TESTI20094620, TESTI20097270, TESTI20107340, TESTI20113150,
TESTI20117500, TESTI201184S0, TESTI20122440, TESTI20124440,
TESTI20125440, TESTI20132680, TESTI20134010, TESTI20134270,
TESTI20142480, TESTI20151050, TESTI20152490, TESTI20159380,
TESTI20161010, TESTI20165680, TESTI20167580, TESTI20170690,
TESTI20170890, TESTI20173110, TESTI20179510, TESTI20182210,
TESTI20184280, TESTI20184820, TESTI20192570, TESTI20193520,
TESTI20197290, TESTI20198600, TESTI20199980, TESTI20200120,
TESTI20200840, TESTI20205150, TESTI20211380, TESTI20219390,
TESTI20221790, TESTI20223380, TESTI20248850, TESTI20254090,
TESTI20254480, TESTI20259200, TESTI20260140, TESTI20265150,
TESTI20265340, TESTI20265890, TESTI20269250, TESTI20269360,
TESTI20272380, TESTI20277300, TESTI20287760, THYMU20007750,
THYMU20008000, THYMU20009460, THYMU20009710, THYMU20010710,
THYMU20012560, THYMU20014430, THYMU20018390, THYMU20019000,
THYMU20020370, THYMU20021540, THYMU20029830, THYMU20036500,
THYMU20043440, THYMU20043560, THYMU20044100, THYMU20044520,
THYMU20051340, THYMU20058550, THYMU20060480, THYMU20062520,
THYMU20064680, THYMU20069130, THYMU20069460, THYMU20069650,
THYMU20071460, THYMU20072580, THYMU20073070, THYMU20073080,
THYMU20078020, THYMU20080490, THYMU20083500, THYMU20084520,
THYMU20086430, THYMU20089170, THYMU20089900, THYMU20091040,
THYMU20112570, THYMU20115730, THYMU20117850, THYMU20128910,
THYMU20129020, THYMU20130470, THYMU20134260, THYMU20140510,
THYMU20148010, THYMU20149230, THYMU20157620, THYMU20174490,
THYMU20174790, THYMU20175260, THYMU20177070, THYMU20181890,
THYMU20187210, TKIDN10001710, TRACH20012490, TRACH20021000,
TRACH20025370, TRACH20026640, TRACH20041090, TRACH20044990,
TRACH20049500, TRACH20051590, TRACH20057200, TRACH20080810,
TRACH20093480, TRACH20101590, TRACH20123870, TRACH20124970,
TRACH20125620, TRACH20129180, TRACH20140180, TRACH20158240,
TRACH20160800, TRACH20174980, TRACH20182780, TRACH20185120,
UTERU10001870, UTERU20000230, UTERU20011760, UTERU20013890,
UTERU20027360, UTERU20029930, UTERU20031350, UTERU20040370,
UTERU20040390, UTERU20040730, UTERU20041970, UTERU20065470,
UTERU20079240, UTERU20090940, UTERU20091470, UTERU20102260,
UTERU20103040, UTERU20106510, UTERU20140010, UTERU20167570,
UTERU20173030, UTERU20176230
EXAMPLE 7
Expression Frequency Analysis In Silico
[1648] The cDNA libraries derived from various tissues and cells as
indicated in Example 1 were prepared, and cDNA clones were selected
from each library at random. The 5'-end sequences were determined
and the database was constructed based on the data. The database
was constructed based on the nucleotide sequences of 770,546
clones, and thus the population of the database is large enough for
the analysis.
[1649] Then, clones having a homologous sequence are categorized
into a single cluster (clustering) by searching the nucleotide
sequences of respective clones in this database with the program of
nucleotide sequence homology search; the number of clones belonging
to each cluster was determined and normalized for every library;
thus, the ratio of a certain gene in each cDNA library was
determined. This analysis gave the information of the expression
frequency of genes in tissues and cells which were sources of the
cDNA libraries.
[1650] Then, in order to analyze the expression of a gene
containing the nucleotide sequence of the cDNA of the present
invention in tissues and cells, the library derived from a tissue
or a cell used in the large-scale cDNA analysis was subjected to
the comparison of the expression levels between tissues or cells.
Namely, the expression frequency was analyzed by comparing the
previously normalized values between tissues and/or cells for which
the nucleotide sequences of 600 or more cDNA clones had been
analyzed. By this analysis, some of the genes were revealed to be
involved in the pathology and functions indicated below. Each value
in Tables 3 to 39 shown below represents a relative expression
frequency; the higher the value, the higher the expression
level.
Osteoporosis-Related Genes
[1651] Osteoporosis is a pathology in which bones are easily broken
owing to overall decrease in components of bone. The onset involves
the balance between the functions of osteoblast producing bone and
osteoclast absorbing bone, namely bone metabolism. Thus, the genes
involved in the increase of osteoclasts differentiating from
precursor cells of monocyte/macrophage line (Molecular Medicine 38.
642-648. (2001)) are genes involved in osteoporosis relevant to
bone metabolism.
[1652] A nucleotide sequence information-based analysis was carried
out to identify the genes whose expression frequencies are higher
or lower in CD34+ cell (cell expressing a glycoprotein CD34)
treated with the osteoclast differentiation factor (Molecular
Medicine 38. 642-648. (2001)) than in the untreated CD34+ cell,
which is the precursor cell of monocyte/macrophage line. The result
of comparative analysis for the frequency between the two cDNA
libraries prepared from the RNA of CD34+ cells (CD34C) and from the
RNA of CD34+ cells treated with the osteoclast differentiation
factor (D30ST, D60ST or D90ST) showed that the genes whose
expression levels were different between the two were the following
clones (Table 3). TABLE-US-00051 ASTRO20010290, BRAMY20036530,
BRAMY20043630, BRAMY20089770, BRAMY20190550, CD34C20001750,
FCBBF20066340, FEBRA20040290, HLUNG20015180, HLUNG20041590,
HLUNG20052300, KIDNE20084040, MESAN20021860, MESAN20027240,
NTONG20055200, PROST20016760, PUAEN10001640, SMINT20006020,
SMINT20028840, SMINT20035050, SPLEN20181570, TESTI20064530,
TESTI20210030, THYMU20029830, THYMU20139160, TRACH20051590
[1653] These genes are involved in osteoporosis.
Genes Involved in Neural Cell Differentiation
[1654] Genes involved in neural cell differentiation are useful for
treating neurological diseases. Genes with varying expression
levels in response to induction of cellular differentiation in
neural cells are thought to be involved in neurological
diseases.
[1655] A survey was performed for genes whose expression levels are
varied in response to induction of differentiation (stimulation by
retinoic acid (RA) or growth inhibitor treatment after RA
stimulation) in cultured cells of a neural strain, NT2. The result
of comparative analysis of cDNA libraries derived from
undifferentiated NT2 cells (NT2RM) and the cells subjected to the
differentiation treatment (NT2RP, NT2RI or NT2NE) showed that the
genes whose expression levels were different between the two were
the following clones (Table 4). TABLE-US-00052 ADRGL20023920,
ASTRO20009140, BNGH420077980, BNGH420086030, BRACE20062580,
BRACE20079370, BRACE20215410, BRAMY20003540, BRAMY20043630,
BRAMY20076130, BRAMY20095080, BRAMY20227860, BRAWH20082550,
BRHIP10001040, BRSSN20005610, CTONG20027660, CTONG20044230,
CTONG20066110, CTONG20079590, CTONG20084660, CTONG20133720,
CTONG20165750, CTONG20188080, FCBBF20023490, FCBBF20033360,
FCBBF20059660, FCBBF20070950, FCBBF30004340, FCBBF30095410,
FCBBF30125460, FCBBF30179180, FCBBF30236670, FCBBF30257370,
FCBBF50000610, FCBBF50001650, FEBRA20038330, FEBRA20039260,
FEBRA20063720, FEBRA20090220, FEBRA20150420, HEART10001490,
HLUNG20032460, HLUNG20041590, KIDNE20089870, MESAN20016270,
MESAN20021860, MESAN20060430, MESAN20067430, NT2NE20018740,
NT2NE20018890, NT2NE20021860, NT2NE20026200, NT2NE20026510,
NT2NE20028700, NT2NE20033150, NT2NE20037050, NT2NE20038870,
NT2NE20039210, NT2NE20042550, NT2NE20045190, NT2NE20047870,
NT2NE20053230, NT2NE20053950, NT2NE20059210, NT2NE20059680,
NT2NE20060750, NT2NE20061030, NT2NE20062880, NT2NE20064780,
NT2NE20066590, NT2NE20069580, NT2NE20070520, NT2NE20073650,
NT2NE20077250, NT2NE20077270, NT2NE20077860, NT2NE20079670,
NT2NE20080770, NT2NE20082130, NT2NE20082600, NT2NE20086070,
NT2NE20087270, NT2NE20087850, NT2NE20088030, NT2NE20092950,
NT2NE20095230, NT2NE20104000, NT2NE20107810, NT2NE20108420,
NT2NE20111190, NT2NE20112210, NT2NE20114850, NT2NE20117580,
NT2NE20119980, NT2NE20123610, NT2NE20124570, NT2NE20126030,
NT2NE20127900, NT2NE20140130, NT2NE20140280, NT2NE20141040,
NT2NE20145250, NT2NE20146510, NT2NE20148690, NT2NE20149500,
NT2NE20150610, NT2NE20152620, NT2NE20153620, NT2NE20155650,
NT2NE20157120, NT2NE20165190, NT2NE20167660, NT2NE20173970,
NT2NE20177210, NT2NE20181760, NT2NE20181800, NT2NE20184720,
NT2RI20016240, NT2RI20021200, NT2RI20033920, NT2RI20093010,
NT2RP70001120, NT2RP70001730, NT2RP70003110, NT2RP70012830,
NT2RP70022820, NT2RP70027790, NT2RP70029780, NT2RP70030840,
NT2RP70031070, NT2RP70031340, NT2RP70031480, NT2RP70035110,
NT2RP70046410, NT2RP70049610, NT2RP70056290, NT2RP70056690,
NT2RP70057500, NT2RP70064570, NT2RP70074800, NT2RP70075300,
NT2RP70075800, NT2RP70080150, NT2RP70084540, NT2RP70087140,
NT2RP70090870, OCBBF20001780, OCBBF20009820, OCBBF20142290,
OCBBF20155030, OCBBF20175360, OCBBF20177540, OCBBF20177910,
PLACE60054820, PLACE60061370, PLACE60073090, PLACE60162100,
PROST20011800, PROST20045700, PROST20078710, PROST20094000,
PUAEN10000650, PUAEN10001640, SKNMC20006350, SMINT20016150,
SMINT20030740, SMINT20035510, SMINT20039050, SMINT20047290,
SPLEN20063250, SPLEN20117580, SPLEN20125230, TESTI20030610,
TESTI20043910, TESTI20066280, TESTI20067480, TESTI20105130,
TESTI20106170, TESTI20143180, TESTI20221790, TESTI20254090,
TESTI20274960, THYMU10004280, THYMU20007020, THYMU20104480,
THYMU20139160, TRACH20026640, UTERU10001060, UTERU20026620,
UTERU20079240, UTERU20083020, UTERU20102260, UTERU20132620
[1656] These genes are neurological disease-related genes.
Cancer-Related Genes
[1657] It has been assumed that, distinct from normal tissues,
cancer tissues express a distinct set of genes, and thus the
expression can contribute to the carcinogenesis in tissues and
cells. Thus, the genes whose expression patterns in cancer tissues
are different from those in normal tissues are cancer-related
genes. Search was carried out for the genes whose expression levels
in cancer tissues were different from those in normal tissues.
[1658] The result of comparative analysis of cDNA libraries derived
from breast tumor (TBAES) and normal breast (BEAST) showed that the
genes whose expression levels were different between the two were
the following clones (Table 5).
CTONG20070780, CTONG20084660, HLUNG20045340, TESTI20047370
[1659] The result of comparative analysis of cDNA libraries derived
cervical tumor (TCERX) and normal cervical duct (CERVX) showed that
the genes whose expression levels were different between the two
were the following clones (Table 6).
SMINT20030740
[1660] The result of comparative analysis of cDNA libraries derived
from colon tumor (TCOLN) and normal colon (COLON) showed that the
genes whose expression levels were different between the two were
the following clones (Table 7).
UTERU2004037
[1661] The result of comparative analysis of cDNA libraries derived
from esophageal tumor (TESOP) and normal esophagus (NESOP) showed
that the genes whose expression levels were different between the
two were the following clones (Table 8). TABLE-US-00053
HLUNG20015180, NESOP20004520, NESOP20005040, TESOP10000350,
TESOP10001600, THYMU20071120
[1662] The result of comparative analysis of cDNA libraries derived
from kidney tumor (TKIDN) and normal kidney (KIDNE) showed that the
genes whose expression levels were different between the two were
the following clones (Table 9). TABLE-US-00054 ASTRO20009140,
ASTRO20027330, ASTRO20055930, BGGI120010750, BNGH420074600,
BRACE20050870, BRACE20054480, BRACE20062580, BRACE20219360,
BRAMY20003540, BRAMY20003880, BRAMY20043630, BRAMY20055760,
BRAMY20125360, BRAMY20190550, BRAMY20204270, BRAMY20227860,
BRAWH20014590, BRAWH20093070, BRHIP10001040, CTONG20033750,
CTONG20039370, CTONG20045500, CTONG20079590, FCBBF20023490,
FCBBF30004340, FCBBF30106950, FCBBF30115230, FCBBF30169280,
FCBBF30225930, FCBBF30282020, FEBRA20038330, FEBRA20039260,
FEBRA20040290, FEBRA20082660, FEBRA20121200, FEBRA20170240,
HEART10001490, HLUNG20041590, HLUNG20068120, HLUNG20072450,
HLUNG20083480, HLUNG20083960, KIDNE20011600, KIDNE20016360,
KIDNE20024380, KIDNE20027980, KIDNE20080690, KIDNE20081170,
KIDNE20083150, KIDNE20083620, KIDNE20084030, KIDNE20084040,
KIDNE20084730, KIDNE20084800, KIDNE20086490, KIDNE20086660,
KIDNE20086970, KIDNE20087880, KIDNE20088240, KIDNE20089870,
KIDNE20091090, KIDNE20094260, KIDNE20094670, KIDNE20095530,
KIDNE20133460, KIDNE20133880, KIDNE20134130, KIDNE20134890,
KIDNE20137310, KIDNE20138450, KIDNE20140870, KIDNE20141120,
KIDNE20141700, KIDNE20142680, KIDNE20142680, KIDNE20142900,
KIDNE20143200, KIDNE20147170, KIDNE20148080, KIDNE20149780,
KIDNE20150730, KIDNE20152440, KIDNE20154330, KIDNE20154830,
KIDNE20155980, KIDNE20157100, KIDNE20160360, KIDNE20160960,
KIDNE20163710, KIDNE20165390, KIDNE20169180, KIDNE20170400,
KIDNE20173150, KIDNE20173430, KIDNE20176030, KIDNE20181670,
KIDNE20182540, KIDNE20186170, KIDNE20188630, KIDNE20189890,
KIDNE20189960, KIDNE20191870, MESAN20038520, MESAN20041380,
OCBBF20016390, OCBBF20142290, OCBBF20174890, PLACE60061370,
PLACE60073090, PLACE60181870, PROST20016760, PUAEN10000650,
SMINT20039050, SMINT20089210, SPLEN20017610, SPLEN20024930,
SPLEN20057830, SPLEN20063250, SPLEN20126110, SPLEN20135030,
SPLEN20136700, TESTI20070740, TESTI20262150, THYMU20009500,
THYMU20019260, THYMU20157620, TKIDN10000620, TKIDN10001710,
TKIDN10001920, TRACH20011010, UMVEN10001380
[1663] The result of comparative analysis of cDNA libraries derived
from liver tumor (TLIVE) and normal liver (LIVER) showed that the
genes whose expression levels were different between the two were
the following clones (Table 10). TABLE-US-00055 CTONG20069320,
FCBBF30236670, FEBRA20038220, FEBRA20039260, KIDNE20087880,
LIVER20006260, LIVER20007690, LIVER20007750, LIVER20010510,
LIVER20010760, LIVER20010990, LIVER20011640, LIVER20013890,
LIVER20026440, LIVER20030650, LIVER20032340, LIVER20038000,
LIVER20040740, LIVER20055270, MESAN20027240, NT2RI20021200,
SKMUS20006790, TESTI20035330, THYMU10004280, THYMU20029830
[1664] The result of comparative analysis of cDNA libraries derived
from lung tumor (TLUNG) and normal lung (HLUNG) showed that the
genes whose expression levels were different between the two were
the following clones (Table 11). TABLE-US-00056 HLUNG20052300,
SMINT20035050, HLUNG20041590, PROST20016760, BRAMY20043630,
HLUNG20015180, THYMU20139160, HLUNG20020850, HLUNG20032460,
BRAMY20204270, BRAMY20001510, BRAMY20227860, CTONG20029030,
CTONG20168460, CTONG20186290, FEBRA20039260, FEBRA20078800,
FEBRA20163980, HCHON20000870, HLUNG20008460, HLUNG20009260,
HLUNG20009550, HLUNG20010130, HLUNG20011260, HLUNG20011440,
HLUNG20011460, HLUNG20012140, HLUNG20014590, HLUNG20015070,
HLUNG20020500, HLUNG20021450, HLUNG20023030, HLUNG20024050,
HLUNG20025620, HLUNG20028110, HLUNG20029420, HLUNG20029490,
HLUNG20030420, HLUNG20030490, HLUNG20030610, HLUNG20031620,
HLUNG20033060, HLUNG20033310, HLUNG20033350, HLUNG20034970,
HLUNG20037140, HLUNG20037160, HLUNG20037780, HLUNG20038330,
HLUNG20041540, HLUNG20042730, HLUNG20045340, HLUNG20047070,
HLUNG20050760, HLUNG20051330, HLUNG20054790, HLUNG20055240,
HLUNG20056560, HLUNG20057380, HLUNG20059240, HLUNG20060670,
HLUNG20063700, HLUNG20065700, HLUNG20065990, HLUNG20067810,
HLUNG20068120, HLUNG20069350, HLUNG20070410, HLUNG20072100,
HLUNG20072190, HLUNG20072450, HLUNG20074330, HLUNG20079310,
HLUNG20081390, HLUNG20081530, HLUNG20082350, HLUNG20083330,
HLUNG20083480, HLUNG20083840, HLUNG20083960, HLUNG20084790,
HLUNG20085210, HLUNG20088750, HLUNG20092530, HLUNG20093030,
HLUNG20094130, KIDNE20142900, PROST20052850, SKNMC20006350,
SPLEN20012450, TESTI20057590, TESTI20061200, TESTI20067480,
TESTI20116050, THYMU10004280, THYMU20010180, TRACH20011010,
UTERU20016580, UTERU20127030
[1665] The result of comparative analysis of cDNA libraries derived
from ovary tumor (TOVER) and normal ovary (NOVER) showed the genes
whose expression levels were different between the two were the
following clones (Table 12).
KIDNE20089870, NT2RP70075300, TESTI20132310
[1666] The result of comparative analysis of cDNA libraries derived
from stomach tumor (TSTOM) and normal stomach (STOMA) showed that
the genes whose expression levels were different between the two
were the following clones (Table 13). TABLE-US-00057 BNGH420087430,
BRAMY20227860, BRAWH20027250, CTONG20174440, FEBRA20090220,
PUAEN10000650, SMINT20023110, SMINT20030740, SMINT20045890,
SPLEN20048800, SPLEN20139360, TESTI20063410, TESTI20150920,
TRACH20026640, UTERU20041970
[1667] The result of comparative analysis of cDNA libraries derived
from uterine tumor (TUTER) and normal uterus (UTERU) showed that
the genes whose expression levels were different between the two
were the following clones (Table 14). TABLE-US-00058 ADRGL20020290,
BRACE20038920, BRAMY20091230, BRAMY20093490, BRAMY20227860,
BRHIP20005060, CTONG20069320, CTONG20083430, FCBBF30005360,
FCBBF30257370, FEBRA20038330, FEBRA20039260, FEBRA20040260,
FEBRA20078180, FEBRA20087550, HLUNG20015070, HLUNG20015180,
MESAN20007110, MESAN20067430, MESAN20095800, NT2RP70057500,
SKMUS20008730, SKNMC20006350, SMINT20035050, SMINT20045890,
SPLEN20073880, SPLEN20076470, SPLEN20118050, TESTI20030610,
TESTI20035330, TESTI20057590, TESTI20059080, TESTI20105130,
THYMU10004280, THYMU20139160, UTERU10001060, UTERU10001870,
UTERU20000230, UTERU20000950, UTERU20011760, UTERU20013890,
UTERU20016580, UTERU20026620, UTERU20027360, UTERU20029930,
UTERU20031350, UTERU20035770, UTERU20040150, UTERU20040370,
UTERU20040390, UTERU20040730, UTERU20041630, UTERU20041970,
UTERU20045200, UTERU20051790, UTERU20064120, UTERU20065470,
UTERU20079240, UTERU20083020, UTERU20086530, UTERU20087070,
UTERU20087850, UTERU20089300, UTERU20089390, UTERU20089620,
UTERU20090940, UTERU20091470, UTERU20094830, UTERU20095100,
UTERU20099040, UTERU20099510, UTERU20101150, UTERU20102260,
UTERU20103040, UTERU20103200, UTERU20104310, UTERU20106510,
UTERU20121140, UTERU20122520, UTERU20125810, UTERU20127030,
UTERU20127150, UTERU20128560, UTERU20132620, UTERU20134830,
UTERU20139760, UTERU20140010, UTERU20167570, UTERU20168960,
UTERU20169020, UTERU20173030, UTERU20176230, UTERU20177150,
UTERU20181270, UTERU20185220, UTERU20188670, UTERU20188840
[1668] The result of comparative analysis of cDNA libraries derived
from tongue cancer (CTONG) and normal tongue (NTONG) showed that
the genes whose expression levels were different between the two
were the following clones (Table 15). TABLE-US-00059 ADRGL20023920,
BRACE20038920, BRACE20050870, BRACE20061620, BRAMY20036530,
BRAMY20076130, BRAMY20204270, BRAMY20267780, BRCAN10001680,
CTONG10000090, CTONG20000340, CTONG20002790, CTONG20004110,
CTONG20004520, CTONG20007660, CTONG20008190, CTONG20008460,
CTONG20015240, CTONG20017490, CTONG20020660, CTONG20020950,
CTONG20027660, CTONG20029030, CTONG20030280, CTONG20031150,
CTONG20031890, CTONG20032930, CTONG20033500, CTONG20033610,
CTONG20033750, CTONG20035240, CTONG20036800, CTONG20036990,
CTONG20039370, CTONG20041150, CTONG20041260, CTONG20042640,
CTONG20044230, CTONG20044870, CTONG20045500, CTONG20046690,
CTONG20049480, CTONG20050490, CTONG20051100, CTONG20051450,
CTONG20052780, CTONG20053990, CTONG20055670, CTONG20055850,
CTONG20056150, CTONG20057750, CTONG20057950, CTONG20059130,
CTONG20060040, CTONG20061290, CTONG20062730, CTONG20063770,
CTONG20063930, CTONG20065240, CTONG20065680, CTONG20066110,
CTONG20068360, CTONG20069320, CTONG20069420, CTONG20070090,
CTONG20070720, CTONG20070780, CTONG20070910, CTONG20071040,
CTONG20071680, CTONG20072930, CTONG20073990, CTONG20074000,
CTONG20074170, CTONG20074740, CTONG20076230, CTONG20076810,
CTONG20077760, CTONG20078340, CTONG20079590, CTONG20080140,
CTONG20081840, CTONG20083430, CTONG20083980, CTONG20084020,
CTONG20084660, CTONG20085210, CTONG20133720, CTONG20165590,
CTONG20165750, CTONG20166580, CTONG20167750, CTONG20168240,
CTONG20168460, CTONG20169040, CTONG20169530, CTONG20170940,
CTONG20174290, CTONG20174580, CTONG20176040, CTONG20179390,
CTONG20179890, CTONG20179980, CTONG20180620, CTONG20180690,
CTONG20181350, CTONG20183430, CTONG20183830, CTONG20184130,
CTONG20184830, CTONG20186140, CTONG20186290, CTONG20186370,
CTONG20186520, CTONG20186550, CTONG20188080, CTONG20189000,
CTONG20190290, CTONG20190630, FCBBF20070950, FCBBF30001100,
FCBBF30175350, FCBBF40005000, FEBRA20027070, FEBRA20038330,
FEBRA20039260, FEBRA20040290, FEBRA20046200, FEBRA20063720,
FEBRA20078800, FEBRA20090220, HCHON20000870, HLUNG20068120,
MESAN20008150, MESAN20027900, NT2NE20153620, NT2RP70001730,
NT2RP70012830, NT2R270027790, NT2RP70057500, NT2RP70064570,
NT2RP70090870, NTONG20002230, NTONG20005310, NTONG20017620,
NTONG20029850, NTONG20031580, NTONG20032100, NTONG20034540,
NTONG20035150, NTONG20043080, NTONG20048440, NTONG20049180,
NTONG20053630, NTONG20053730, NTONG20053910, NTONG20055200,
NTONG20058010, NTONG20058220, OCBBF20110730, OCBBF20177540,
OCBBF20177910, PROST20016760, PROST20042700, PROST20050390,
PROST20063430, PROST20130320, PUAEN10000650, PUAEN10001640,
PUAEN20003120, SKMUS20006790, SKNMC20006350, SKNSH20007160,
SMINT20030740, SMINT20035510, SMINT20089210, SPLEN20024930,
SPLEN20040780, SPLEN20063250, SPLEN20181570, SPLEN20187490,
TESTI20047370, TESTI20057880, TESTI20064530, TESTI20079980,
TESTI20105130, TESTI20118460, TESTI20121040, TESTI20197290,
THYMU10004280, THYMU20030460, THYMU20055460, THYMU20089900,
THYMU20121040, THYMU20139160, THYMU20145990, TRACH20011010,
TRACH20090060, UTERU20000230, UTERU20000950, UTERU20016580,
UTERU20045200, UTERU20083020
[1669] These genes are involved in cancers.
[1670] Further, there is a method to search for genes involved in
development and differentiation: the expression frequency analysis
in which the expression levels of genes are compared between
developing or differentiating tissues and/or cells and adult
tissues and/or cells. The genes involved in tissue development
and/or differentiation are genes participating in tissue
construction and expression of function, and thus are useful genes,
which are available for regenerative medicine aiming at convenient
regeneration of injured tissues.
[1671] Search was carried out for the genes whose expression
frequencies were different between developing and/or
differentiating tissues and/or cells, and adult tissues and/or
cells, by using the information of gene expression frequency based
on the database of the nucleotide sequences of 770,546 clones shown
above.
[1672] The result of comparative analysis of cDNA libraries derived
from fetal brain (FCBBF, FEBRA or OCBBF) and adult brain (BRACE,
BRALZ, BRAMY, BRAWH, BRCAN, BRCOC, BRHIP, BRSSN, BRSTN or BRTHA)
showed that the genes whose expression levels were different
between the two were the following clones (Tables 16 to 36).
TABLE-US-00060 ADRGL20020290, ADRGL20021910, ADRGL20023920,
ADRGL20046760, ADRGL20062330, ADRGL20079060, ASTRO20009140,
ASTRO20020240, ASTRO20027330, ASTRO20047510, ASTRO20055530,
ASTRO20055570, ASTRO20055930, ASTRO20090680, BGGI120010750,
BNGH420021680, BNGH420023870, BNGH420059680, BNGH420074600,
BNGH420086030, BRACE10000510, BRACE20003310, BRACE20007330,
BRACE20009050, BRACE20014450, BRACE20017790, BRACE20018810,
BRACE20025820, BRACE20038920, BRACE20050870, BRACE20051600,
BRACE20051930, BRACE20052430, BRACE20052530, BRACE20054080,
BRACE20054480, BRACE20054600, BRACE20055560, BRACE20057870,
BRACE20059110, BRACE20059810, BRACE20061620, BRACE20062580,
BRACE20063540, BRACE20065470, BRACE20066360, BRACE20068710,
BRACE20069000, BRACE20069110, BRACE20069440, BRACE20079200,
BRACE20079370, BRACE20097540, BRACE20098860, BRACE20099070,
BRACE20194670, BRACE20196180, BRACE20196960, BRACE20200770,
BRACE20200970, BRACE20204670, BRACE20205840, BRACE20207420,
BRACE20212450, BRACE20215410, BRACE20216700, BRACE20216950,
BRACE20219360, BRAMY10000980, BRAMY10001730, BRAMY20000210,
BRAMY20000250, BRAMY20001510, BRAMY20003540, BRAMY20003880,
BRAMY20005080, BRAMY20013670, BRAMY20016780, BRAMY20020440,
BRAMY20021580, BRAMY20023390, BRAMY20023640, BRAMY20024790,
BRAMY20027390, BRAMY20027990, BRAMY20028530, BRAMY20028620,
BRAMY20035380, BRAMY20035830, BRAMY20036530, BRAMY20036810,
BRAMY20038980, BRAMY20039290, BRAMY20040580, BRAMY20043520,
BRAMY20043630, BRAMY20044920, BRAMY20045210, BRAMY20045420,
BRAMY20047560, BRAMY20050640, BRAMY20050940, BRAMY20051820,
BRAMY20052440, BRAMY20053910, BRAMY20055760, BRAMY20056620,
BRAMY20056840, BRAMY20063750, BRAMY20072440, BRAMY20072870,
BRAMY20073080, BRAMY20074110, BRAMY20074860, BRAMY20076100,
BRAMY20076130, BRAMY20076530, BRAMY20083330, BRAMY20083820,
BRAMY20089770, BRAMY20091230, BRAMY20093490, BRAMY20094890,
BRAMY20095080, BRAMY20095570, BRAMY20096930, BRAMY20100680,
BRAMY20102900, BRAMY20107980, BRAMY20111780, BRAMY20117670,
BRAMY20118410, BRAMY20118490, BRAMY20120170, BRAMY20123400,
BRAMY20124970, BRAMY20125170, BRAMY20125360, BRAMY20125550,
BRAMY20126910, BRAMY20127310, BRAMY20127760, BRAMY20134050,
BRAMY20135720, BRAMY20137360, BRAMY20139440, BRAMY20139750,
BRAMY20143870, BRAMY20152510, BRAMY20155500, BRAMY20158550,
BRAMY20159250, BRAMY20160020, BRAMY20173480, BRAMY20190550,
BRAMY20194680, BRAMY20204270, BRAMY20206340, BRAMY20219620,
BRAMY20221600, BRAMY20223010, BRAMY20225250, BRAMY20225320,
BRAMY20227230, BRAMY20227860, BRAMY20227960, BRAMY20231150,
BRAMY20234820, BRAMY20237190, BRAMY20238630, BRAMY20243120,
BRAMY20244490, BRAMY20245140, BRAMY20245350, BRAMY20245760,
BRAMY20251210, BRAMY20251750, BRAMY20263000, BRAMY20267780,
BRAMY20269040, BRAMY20271140, BRAMY20274510, BRAMY20285650,
BRAMY20287400, BRAWH20014590, BRAWH20020470, BRAWH20020600,
BRAWH20021910, BRAWH20025490, BRAWH20026010, BRAWH20027250,
BRAWH20030000, BRAWH20039640, BRAWH20040680, BRAWH20047790,
BRAWH20050740, BRAWH20055240, BRAWH20055330, BRAWH20055780,
BRAWH20058120, BRAWH20063010, BRAWH20078080, BRAWH20078620,
BRAWH20080580, BRAWH20082550, BRAWH20082920, BRAWH20093040,
BRAWH20093070, BRAWH20094900, BRAWH20095900, BRAWH20173790,
BRAWH20174330, BRAWH20175230, BBAWH20175340, BRAWH20176850,
BRAWH20182670, BRAWH20183170, BRAWH20185260, BRAWH20185270,
BRAWH20186010, BRAWH20188750, BRAWH20190530, BRAWH20190550,
BRAWH20191980, BRCAN10000760, BRCAN10001050, BRCAN10001680,
BRCAN20001480, BRCAN20004180, BRCAN20005230, BRCAN20005410,
BRCOC10000400, BRCOC20000470, BRCOC20003600, BRHIP10000720,
BRHIP10001040, BRHIP20000210, BRHIP20003590, BRHIP20005060,
BRSSN20001970, BRSSN20005610, BRSSN20005660, BRSSN20066440,
BRSSN20074640, BRSSN20091190, BRSSN20092440, BRSSN20093890,
CTONG20032930, CTONG20035240, CTONG20044870, CTONG20063930,
CTONG20069320, CTONG20070720, CTONG20071040, CTONG20071680,
CTONG20074170, CTONG20078340, CTONG20079590, CTONG20080140,
CTONG20085210, CTONG20133720, CTONG20165750, CTONG20168240,
CTONG20170940, CTONG20183430, CTONG20186370, CTONG20188080,
FCBBF10000230, FCBBF10002200, FCBBF10004760, FCBBF20018680,
FCBBF20020440, FCBBF20021110, FCBBF20023490, FCBBF20028980,
FCBBF20029280, FCBBF20032930, FCBBF20033360, FCBBF20035430,
FCBBF20035490, FCBBF20036360, FCBBF20038230, FCBBF20038950,
FCBBF20041380, FCBBF20043730, FCBBF20054390, FCBBF20056580,
FCBBF20059660, FCBBF20061310, FCBBF20066340, FCBBF20070800,
FCBBF20070950, FCBBF30000010, FCBBF30001020, FCBBF30001100,
FCBBF30001150, FCBBF30002270, FCBBF30002280, FCBBF30002330,
FCBBF30003610, FCBBF30004340, FCBBF30004730, FCBBF30005180,
FCBBF30005360, FCBBF30005500, FCBBF30019140, FCBBF30019180,
FCBBF30019240, FCBBF30021900, FCBBF30022680, FCBBF30026580,
FCBBF30029250, FCBBF30035570, FCBBF30042610, FCBBF30048420,
FCBBF30053300, FCBBF30056980, FCBBF30062490, FCBBF30063990,
FCBBF30068210, FCBBF30071500, FCBBF30072440, FCBBF30072480,
FCBBF30074530, FCBBF30074620, FCBBF30075970, FCBBF30076310,
FCBBF30078600, FCBBF30079770, FCBBF30080730, FCBBF30081000,
FCBBF30085560, FCBBF30088700, FCBBF30089380, FCBBF30091010,
FCBBF30091520, FCBBF30093170, FCBBF30095410, FCBBF30099490,
FCBBF30100080, FCBBF30100120, FCBBF30100410, FCBBF30101240,
FCBBF30101300, FCBBF30105080, FCBBF30105440, FCBBF30105860,
FCBBF30106950, FCBBF30107290, FCBBF30107330, FCBBF30114180,
FCBBF30114850, FCBBF30115230, FCBBF30115920, FCBBF30118670,
FCBBF30118890, FCBBF30125460, FCBBF30125880, FCBBF30128420,
FCBBF30129010, FCBBF30130410, FCBBF30130580, FCBBF30132050,
FCBBF30132660, FCBBF30135890, FCBBF30136230, FCBBF30138000,
FCBBF30142290, FCBBF30143550, FCBBF30145670, FCBBF30151190,
FCBBF30153170, FCBBF30157270, FCBBF30161780, FCBBF30164510,
FCBBF30166220, FCBBF30169280, FCBBF30169870, FCBBF30170710,
FCBBF30171230, FCBBF30172330, FCBBF30173960, FCBBF30175350,
FCBBF30177290, FCBBF30179180, FCBBF30179740, FCBBF30181730,
FCBBF30194370, FCBBF30194550, FCBBF30195690, FCBBF30195700,
FCBBF30197840, FCBBF30198670, FCBBF30201630, FCBBF30212210,
FCBBF30215240, FCBBF30220050, FCBBF30222910, FCBBF30223110,
FCBBF30223210, FCBBF30225930, FCBBF30228940, FCBBF30230610,
FCBBF30236670, FCBBF30250980, FCBBF30255680, FCBBF30257370,
FCBBF30259050, FCBBF30260210, FCBBF30260480, FCBBF30263080,
FCBBF30266510, FCBBF30271990, FCBBF30275590, FCBBF30282020,
FCBBF30285930, FCBBF30287940, FCBBF40000610, FCBBF40001920,
FCBBF40005000, FCBBF50000410, FCBBF50000610, FCBBF50001650,
FCBBF50003530, FCBBF50004950, FEBRA20005040, FEBRA20007820,
FEBRA20018670, FEBRA20026820, FEBRA20027070, FEBRA20029620,
FEBRA20031000, FEBRA20031150, FEBRA20031280, FEBRA20031810,
FEBRA20035200, FEBRA20035240, FEBRA20038220, FEBRA20038330,
FEBRA20038970, FEBRA20039070, FEBRA20039260, FEBRA20040230,
FEBRA20040260, FEBRA20040290, FEBRA20040560, FEBRA20045380,
FEBRA20046200, FEBRA20046280, FEBRA20046510, FEBRA20057010,
FEBRA20063720, FEBRA20076200, FEBRA20078180, FEBRA20078800,
FEBRA20080860, FEBRA20082660, FEBRA20083410, FEBRA20084750,
FEBRA20086600, FEBRA20087550, FEBRA20088610, FEBRA20088810,
FEBRA20090160, FEBRA20090220, FEBRA20091620, FEBRA20092760,
FEBRA20093270, FEBRA20093280, FEBRA20095410, FEBRA20098040,
FEBRA20099860, FEBRA20101410, FEBRA20108020, FEBRA20108580,
FEBRA20115930, FEBRA20116650, FEBRA20121200, FEBRA20121950,
FEBRA20141980, FEBRA20150420, FEBRA20151750, FEBRA20163980,
FEBRA20170240, FEBRA20172230, FEBRA20173330, FEBRA20175020,
FEBRA20175330, FEBRA20177800, FEBRA20180510, FEBRA20182030,
FEBRA20187460, FEBRA20191720, HCHON20002650, HCHON20002710,
HEART10001490, HLUNG20008460, HLUNG20011460, HLUNG20014590,
HLUNG20015070, HLUNG20015180, HLUNG20020850, HLUNG20028110,
HLUNG20031620, HLUNG20032460, HLUNG20033060, HLUNG20041590,
HLUNG20045340, HLUNG20056560, HLUNG20068120, HLUNG20081390,
HLUNG20083480, HLUNG20085210, HLUNG20094130, KIDNE20080690,
KIDNE20084030, KIDNE20086660, KIDNE20094670, KIDNE20134130,
KIDNE20138450, KIDNE20140870, KIDNE20149780, KIDNE20170400,
KIDNE20173430, MESAN20021860, MESAN20030350, MESAN20034440,
MESAN20038520, MESAN20045750, MESAN20067430, MESAN20089260,
MESAN20095800, NT2NE20026200, NT2NE20033150, NT2NE20042550,
NT2NE20045190, NT2NE20053950, NT2NE20061030, NT2NE20069580,
NT2NE20082130, NT2NE20082600, NT2NE20088030, NT2NE20092950,
NT2NE20095230, NT2NE20108420, NT2NE20111190, NT2NE20112210,
NT2NE20141040, NT2NE20177210, NT2NE20181800, NT2RI20021200,
NT2RP70001120, NT2RP70001730, NT2RP70012830, NT2RP70035110,
NT2RP70057500, NT2RP70075300, NT2RP70087140, NT2RP70090870,
NTONG20002230, NTONG20017620, NTONG20049180, NTONG20055200,
OCBBF20000740, OCBBF20001780, OCBBF20005220, OCBBF20009820,
OCBBF20011860, OCBBF20012520, OCBBF20016390, OCBBF20016810,
OCBBF20109450, OCBBF20109780, OCBBF20110210, OCBBF20110730,
OCBBF20111370, OCBBF20111600, OCBBF20112280, OCBBF20112320,
OCBBF20113110, OCBBF20115360, OCBBF20116250, OCBBF20117220,
OCBBF20118720, OCBBF20119810, OCBBF20120010, OCBBF20120950,
OCBBF20121910, OCBBF20123200, OCBBF20142290, OCBBF20147070,
OCBBF20152330, OCBBF20155030, OCBBF20156450, OCBBF20157970,
OCBBF20160380, OCBBF20165900, OCBBF20165910, OCBBF20166890,
OCBBF20166900, OCBBF20167290, OCBBF20170350, OCBBF20174580,
OCBBF20174890, OCBBF20175360, OCBBF20176650, OCBBF20177540,
OCBBF20177910, OCBBF20182060, OCBBF20185630, OCBBF20188280,
OCBBF20191950, PLACE60054820, PLACE60056910, PLACE60061370,
PLACE60064740, PLACE60073090, PLACE60120280, PLACE60132200,
PLACE60150510, PLACE60154450, PLACE60157310, PLACE60162100,
PROST10002150, PROST20014150, PROST20016760, PROST20024250,
PROST20035170, PROST20035830, PROST20042700, PROST20045700,
PROST20050390, PROST20054660, PROST20078710, PROST20094000,
PROST20097310, PROST20097840, PROST20103820, PROST20114100,
PROST20130320, PROST20151370, PUAEN10000650, PUAEN10001640,
PUAEN20003120, SKNMC20006350, SKNSH10001010, SKNSH20007160,
SKNSH20030640, SKNSH20094350, SMINT20000070, SMINT20002320,
SMINT20030740, SMINT20039050, SMINT20045890, SMINT20047290,
SMINT20048720, SMINT20056240, SMINT20077920, SMINT20088690,
SMINT20089210, SMINT20089600, SMINT20094150, SPLEN20005160,
SPLEN20005370, SPLEN20012450, SPLEN20024930, SPLEN20040780,
SPLEN20048800, SPLEN20055600, SPLEN20057830, SPLEN20063250,
SPLEN20071820, SPLEN20073880, SPLEN20076470, SPLEN20104690,
SPLEN20114190, SPLEN20125230, SPLEN20135030, SPLEN20136700,
SPLEN20175920, SPLEN20181570, SPLEN20183020, SPLEN20187490,
SPLEN20193490, SPLEN20193790, SPLEN20197740, SPLEN20200070,
SPLEN20200340, TESOP10000350, TESTI20005980, TESTI20030440,
TESTI20030610, TESTI20031410, TESTI20035330, TESTI20047370,
TESTI20050400, TESTI20050720, TESTI20053780, TESTI20057430,
TESTI20057590, TESTI20057840, TESTI20057880, TESTI20059080,
TESTI20061200, TESTI20062580, TESTI20063410, TESTI20064530,
TESTI20066280, TESTI20067480, TESTI20071630, TESTI20079980,
TESTI20081890, TESTI20089290, TESTI20090180, TESTI20105130,
TESTI20106170, TESTI20121040, TESTI20150920, TESTI20169500,
TESTI20193080, TESTI20215310, TESTI20221790, TESTI20245860,
TESTI20252690, TESTI20254090, TESTI20261160, TESTI20262150,
TESTI20274960, THYMU20007750, THYMU20009460, THYMU20009710,
THYMU20019260, THYMU20028410, THYMU20030460, THYMU20031330,
THYMU20043440, THYMU20044100, THYMU20044520, THYMU20049060,
THYMU20055460, THYMU20055740, THYMU20071120, THYMU20078020,
THYMU20089900, THYMU20091040, THYMU20104480, THYMU20120240,
THYMU20139160, THYMU20143230, THYMU20150190, THYMU20157620,
THYMU20176010, TKIDN10001920, TRACH20012490, TRACH20021000,
TRACH20026640, TRACH20058000, TRACH20090060, TRACH20159390,
UMVEN10001380, UTERU10001060, UTERU20000230, UTERU20000950,
UTERU20026620, UTERU20041970, UTERU20065470, UTERU20079240,
UTERU20083020, UTERU20089300, UTERU20089390, UTERU20095100,
UTERU20102260, UTERU20103200, UTERU20127150, UTERU20128560
[1673] The result of comparative analysis of cDNA libraries derived
from fetal heart (FEHRT) and adult heart (HEART) showed that the
genes whose expression levels were different between the two were
the following clones (Table 37). TABLE-US-00061 BRAMY20043630,
BRAMY20072870, BRAMY20227860, BRAWH20093070, BRCAN10001680,
FCBBF30053300, FEBRA20078800, FEBRA20090220, HCHON20000870,
HEART10001420, HEART10001490, HEART20009590, HEART20019310,
HEART20022200, HEART20031680, HEART20047640, HEART20063100,
HEART20082570, HLUNG20083960, PLACE60088240, PLACE60120280,
PROST20016760, PROST20035170, PROST20062820, PROST20127450,
SKMUS20006790, SKMUS20008730, TESTI20270130
[1674] The result of comparative analysis of cDNA libraries derived
from fetal kidney (FEKID) and adult kidney (KIDNE) showed that the
genes whose expression levels were different between the two were
the following clones (Table 38). TABLE-US-00062 ASTRO20009140,
BGGI120010750, BRACE20054480, BRACE20062580, BRACE20219360,
BRAMY20001510, BRAMY20003540, BRAMY20003880, BRAMY20043630,
BRAMY20204270, CTONG20033750, CTONG20039370, CTONG20045500,
FCBBF20023490, FEBRA20039260, FEBRA20040290, HEART10001490,
HLUNG20041590, HLUNG20068120, HLUNG20072450, HLUNG20083960,
KIDNE20011600, KIDNE20016360, KIDNE20024380, KIDNE20027980,
KIDNE20080690, KIDNE20081170, KIDNE20083150, KIDNE20083620,
KIDNE20084030, KIDNE20084040, KIDNE20084730, KIDNE20084800,
KIDNE20086490, KIDNE20086660, KIDNE20086970, KIDNE20087880,
KIDNE20088240, KIDNE20089870, KIDNE20091090, KIDNE20094260,
KIDNE20094670, KIDNE20095530, KIDNE20133460, KIDNE20133880,
KIDNE20134130, KIDNE20134890, KIDNE20137310, KIDNE20138450,
KIDNE20140870, KIDNE20141120, KIDNE20141700, KIDNE20142680,
KIDNE20142900, KIDNE20143200, KIDNE20147170, KIDNE20148080,
KIDNE20149780, KIDNE20150730, KIDNE20152440, KIDNE20154330,
KIDNE20154830, KIDNE20155980, KIDNE20157100, KIDNE20160360,
KIDNE20160960, KIDNE20163710, KIDNE20165390, KIDNE20169180,
KIDNE20170400, KIDNE20173150, KIDNE20173430, KIDNE20176030,
KIDNE20181670, KIDNE20182540, KIDNE20186170, KIDNE20188630,
KIDNE20189890, KIDNE20189960, KIDNE20191870, OCBBF20174890,
PLACE60073090, PLACE60181870, PROST20016760, PUAEN10000650,
SKNMC20006350, SPLEN20017610, SPLEN20063250, SPLEN20126110,
SPLEN20135030, TESTI20061200, TESTI20262150, THYMU10004280,
THYMU20139160, TRACH20011010
[1675] The result of comparative analysis of cDNA libraries derived
from fetal lung (FELNG) and adult lung (HLUNG) showed that the
genes whose expression levels were different between the two were
the following clones (Table 39). TABLE-US-00063 BRAMY20001510,
BRAMY20043630, BRAMY20204270, BRAMY20227860, CTONG20029030,
CTONG20168460, CTONG20186290, FEBRA20039260, FEBRA20078800,
FEBRA20163980, HCHON20000870, HLUNG20008460, HLUNG20009260,
HLUNG20009550, HLUNG20010130, HLUNG20011260, HLUNG20011440,
HLUNG20011460, HLUNG20012140, HLUNG20014590, HLUNG20015070,
HLUNG20015180, HLUNG20020500, HLUNG20020850, HLUNG20021450,
HLUNG20023030, HLUNG20024050, HLUNG20025620, HLUNG20028110,
HLUNG20029420, HLUNG20029490, HLUNG20030420, HLUNG20030490,
HLUNG20030610, HLUNG20031620, HLUNG20032460, HLUNG20033060,
HLUNG20033310, HLUNG20033350, HLUNG20034970, HLUNG20037140,
HLUNG20037160, HLUNG20037780, HLUNG20038330, HLUNG20041540,
HLUNG20041590, HLUNG20042730, HLUNG20045340, HLUNG20047070,
HLUNG20050760, HLUNG20051330, HLUNG20052300, HLUNG20054790,
HLUNG20055240, HLUNG20056560, HLUNG20057380, HLUNG20059240,
HLUNG20060670, HLUNG20063700, HLUNG20065700, HLUNG20065990,
HLUNG20067810, HLUNG20068120, HLUNG20069350, HLUNG20070410,
HLUNG20072100, HLUNG20072190, HLUNG20072450, HLUNG20074330,
HLUNG20079310, HLUNG20081390, HLUNG20081530, HLUNG20082350,
HLUNG20083330, HLUNG20083480, HLUNG20083840, HLUNG20083960,
HLUNG20084790, HLUNG20085210, HLUNG20088750, HLUNG20092530,
HLUNG20093030, HLUNG20094130, KIDNE20142900, PROST20016760,
PROST20052850, SKNMC20006350, SMINT20035050, SPLEN20012450,
TESTI20057590, TESTI20061200, TESTI20067480, TESTI20116050,
THYMU10004280, THYMU20010180, THYMU20139160, TRACH20011010,
UTERU20016580, UTERU20127030
[1676] These genes are involved in regeneration of tissues and/or
cells.
EXAMPLE 8
Expression Frequency Analysis by PCR
[1677] Specific PCR primers were prepared based on the full-length
nucleotide sequences, and the expression frequency was analyzed by
the ATAC-PCR method (Adaptor-tagged competitive PCR method: Nucleic
Acids Research 1997, 25 (22): 4694-4696; "DNA Micro-array and
Advanced PCR Techniques", Cell Technology, supplement, Eds.,
Muramatsu and Nawa (Shujunsha, 2000): 104-112).
Inflammation-related genes can be identified by revealing the genes
whose expression levels are altered depending on the presence of an
inflammation-inducing factor. Then, by using THP-1 cell line, which
is a cell line of monocyte line, and TNF-.alpha., which is an
inflammation-inducing factor, suitable for this system, the genes
whose expression levels are altered depending on the presence of
the factor were searched for by the system.
[1678] THP-1 cell line (purchased from DAINIPPON PHARMACEUTICAL)
was cultured to be confluent in RPMI1640 medium (sigma) containing
5% fetal calf serum (GIBCO BRL). Then, the medium was changed with
the medium containing 10 ng/ml TNF-.alpha. (human recombinant
TNF-.alpha.; Pharmacia Biotech), and the culture was continued at
37.degree. C. under 5% CO.sub.2. After three hours, the cells were
harvested, and total RNA was extracted from them by using ISOGEN
reagent (Nippon Gene). The extraction was carried out according to
the method in the document attached to ISOGEN reagent. In addition,
total RNA was also extracted from the cells cultured without
stimulation of TNF-.alpha..
[1679] The genes involved in the onset of gastritis and
gastroduodenal ulcer induced by the infection of Helicobacter
pylori to the epithelia of stomach can be identified by revealing
the genes whose expression levels are altered depending on
co-culturing the cells with Helicobacter pylori. A recent study has
suggested that various substances derived from Helicobacter pylori
trigger the inflammation reaction. In particular, the members
belonging to the family of genes called "cag pathogenicity island
(cag PAI)" contribute to the activation of the NF-.kappa.B pathway
(Gastroenterology 2000, 119: 97-108). Further, it has been found
that cag PAI is involved in the onset of gastritis and the like by
the study using an animal model (Journal of Experimental Medicine
2000, 192:1601-1610). Then, by using co-culture of a gastric cancer
cell line with cag PAI-positive Helicobacter pylori (TN2), suitable
for this system, the genes whose expression levels are altered
depending on the presence of Helicobacter pylori were searched for
by the system. Further, in order to study the involvement of cag
PAI in the alterations of gene expression levels depending on the
co-culture with Helicobacter pylori, the altered expression levels
were compared between the cells co-cultured with a strain of
Helicobacter pylori (TN2.DELTA.cagE strain) having a mutation in
cagE, which is one of the cag PAI genes, and the cag PAI-positive
strain (TN2).
[1680] A gastric cancer cell line MKN45 (provided by the Cell Bank,
RIKEN GENE BANK, The Institute of Physical and Chemical Research)
was cultured to be confluent in RPMI1640 medium (sigma) containing
10% fetal calf serum (GIBCO BRL). Then, the medium was changed with
the medium containing 100-fold excess (in terms of the number of
cells or the number of colonies) of Helicobacter pylori (cag PAI
positive strain (TN2) and cagE mutant (TN2.DELTA.cagE): both were
provided by Prof. Omata, Faculty of Medicine, The University of
Tokyo), as compared with the number of the cancer cells. The
culture was continued at 37.degree. C. under 5% CO.sub.2. After
three hours, the cells were harvested, and total RNA was extracted
from them by using ISOGEN reagent (Nippon Gene). The extraction was
carried out according to the method in the document attached to
ISOGEN reagent. In addition, total RNA was also extracted from the
cells cultured without Helicobacter pylori.
[1681] The analysis by the ATAC-PCR method was carried out
basically according to "DNA Micro-array and Advanced PCR
Techniques", Cell Technology, supplement (Genome Science Series 1,
Eds., Muramatsu and Nawa (Shujunsha, 2000): 104-112). Adapter
ligation to the internal standard sample (sample to make the
calibration curve for the clone of interest) and test sample was
carried out in the two separate reaction systems indicated below.
The combination of 6 types of adapters (AD-1, AD-2, AD-3, AD-4,
AD-5 and AD-6: see the sequences indicated below) and the samples
are as follows.
Reaction System A
[1682] AD1; internal standard, 10-fold [1683] AD2; THP-1 cells,
unstimulated [1684] AD3; internal standard, 3-fold [1685] AD4;
THP-1 cells, TNF-.alpha. stimulation for one hour [1686] AD5; THP-1
cells, TNF-.alpha. stimulation for three hours [1687] AD6; internal
standard, 1-fold Reaction System B [1688] AD1; internal standard,
1-fold [1689] AD2; MKN45 cells, unstimulated [1690] AD3; internal
standard, 3-fold [1691] AD4; MKN45 cells, co-cultured with TN2
(Helicobacter pylori) [1692] AD5; internal standard, 10-fold [1693]
AD6; MKN45 cells, co-cultured with TN2.DELTA.cagE (cagE gene
mutant)
[1694] Adapter Sequences: TABLE-US-00064 AD1; SEQ ID NO: 3941
5'-GTACATATTGTCGTTAGAACGCG-3'// SEQ ID NO: 3942
3'-CATGTATAACAGCAATCTTGCGCCTAG-5'// AD2; SEQ ID NO: 3943
5'-GTACATATTGTCGTTAGAACGCGACT-3'// SEQ ID NO: 3944
3'-CATGTATAACAGCAATCTTGCGCTGACTAG-5'// AD3; SEQ ID NO: 3945
5'-GTACATATTGTCGTTAGAACGCGCATACT-3'// SEQ ID NO: 3946
3'-CATGTATAACAGCAATCTTGCGCGTATGACTAG-5'// AD4; SEQ ID NO: 3947
5'-GTACATATTGTCGTTAGAACGCGATCCATACT-3'// SEQ ID NO: 3948
3'-CATGTATAACAGCAATCTTGCGCTAGGTATGACTAG-5'// AD5; SEQ ID NO: 3949
5'-GTACATATTGTCGTTAGAACGCGTCAATCCATACT-3'// SEQ ID NO: 3950
3'-CATGTATAACAGCAATCTTGCGCAGTTAGGTATGACTAG-5'// AD6; SEQ ID NO:
3951 5'-GTACATATTGTCGTTAGAACGCGTACTCAATCCATACT-3'// SEQ ID NO: 3952
3'-CATGTATAACAGCAATCTTGCGCATGAGTTAGGTATGACTAG-5'//
[1695] The internal standard sample used for this assay was a
mixture of total RNAs from tissues (or culture cells; all from
UNITECH) of brain, kidney, NT2, testis, thymus, and trachea. RNA
was prepared according to the standard method.
[1696] The sequences of primers specific to the genes and the names
of clones of interest in the analysis are as follows. The gene
specific primers were designed to produce the PCR products of 70 to
200 bp, which are derived from the adapter-containing cDNA. The
sequence of adapter-specific primer (labeled with fluorescence
(FAM)) used in the competitive PCR was GTACATATTGTCGTTAGAACGC (22
nucleotides; SEQ ID NO: 3953). PCR was basically carried out with a
cycling profile of preheating at 94.degree. C. for 3 minutes, and
35 or 40 cycles of denaturation at 94.degree. C. for 30
seconds/annealing at 50.degree. C. for 60 seconds/extension at
72.degree. C. for 90 seconds.
The Nucleotide Sequences of Clone Specific Primers Used in the
Experiments
[1697] Clone name, primer sequence and SEQ ID NO are indicated
below in this order. Each is demarcated by a double slash mark
(//). TABLE-US-00065 ADRGL20036380//CTACTCAAGGACAGCCACAC// SEQ ID
NO: 3954 ASTRO20045840//GGATGTAGTGGGAAACAATG// SEQ ID NO: 3955
ASTRO20055930//TGCTTTTCATTCTCCTTAGT// SEQ ID NO: 3956
ASTRO20088950//TACGTGCTCATTTACTTGGT// SEQ ID NO: 3957
BNGH420052350//GCCAGTTTCTTTATGATTGA// SEQ ID NO: 3958
BRACE20052530//AATGACTTCGTTAGGATGCC// SEQ ID NO: 3959
BRACE20054080//GCTGTTGACTTCATTTGGAA// SEQ ID NO: 3960
BRAMY20003880//TTGGTACTTATTCTGAGGCA// SEQ ID NO: 3961
BRAMY20027390//GATTTTAGTGAAACATGCCA// SEQ ID NO: 3962
BRAMY20028530//TTAAAACTGAGGACATTCTG// SEQ ID NO: 3963
BRAMY20035380//AGAGAAGGCAGTCTAGCTTA// SEQ ID NO: 3964
BRAMY20036530//AGGGTATGGTAACTTCTGCA// SEQ ID NO: 3965
BRAMY20050940//AAAGGAGGGACTAGAAAACT// SEQ ID NO: 3966
BRAMY20072440//ACTATGACGAGGGAACAAGA// SEQ ID NO: 3967
BRAMY20096930//GAGGAGAACACAAGTATGGT// SEQ ID NO: 3968
BRAMY20118410//AAGGTCACTTCTAAACACAC// SEQ ID NO: 3969
BRAMY20237190//GGAGTGATTCAGGAGATGTG// SEQ ID NO: 3970
BRAWH20055330//GCAACAGAGACTTTATTGGT// SEQ ID NO: 3971
BRAWH20078620//GAGAGACTTATCACAGCCAT// SEQ ID NO: 3972
BRAWH20190530//ATGGGATTCTGTGACTTCTC// SEQ ID NO: 3973
BRCAN20001480//CAGCAACAGTAATGGGAATT// SEQ ID NO: 3974
BRHIP10000720//AGGTTAGGATTTCTTTAGCA// SEQ ID NO: 3975
BRHIP10001040//TACTTGGAGACAACAGGGAG// SEQ ID NO: 3976
BRHIP20000210//GTGTTTGTGGGCATAGACAT// SEQ ID NO: 3977
BRSSN20001970//AATGTATTCAGTTCCTTTCC// SEQ ID NO: 3978
BRSSN20091190//GTGTCATCACTAGCACCAAG// SEQ ID NO: 3979
CD34C20001750//TGGACTTAGGGACCTGACTC// SEQ ID NO: 3980
CTONG20078340//CTCTTTACCTAGTTTGGTCA// SEQ ID NO: 3981
CTONG20079590//TACTTATTTTCACAGGGGCC// SEQ ID NO: 3982
CTONG20083980//CAGCATTTTCCTATATAGCC// SEQ ID NO: 3983
CTONG20085210//CCAGAAGAGTAGCAAGAATT// SEQ ID NO: 3984
DFNES20063460//CTATTTTAACCCCTGCCCTC// SEQ ID NO: 3985
DFNES20072990//GGAGGTATCTATTAGGGTGA// SEQ ID NO: 3986
FCBBF20029280//GACTGAGATGAACTGGAAGA// SEQ ID NO: 3987
FCBBF20032930//TCACAATACAGTCCCCTAGT// SEQ ID NO: 3988
FCBBF20036360//ATTTGTATCACTTTGGTGCA// SEQ ID NO: 3989
FCBBF30022680//CTCCAGAAAATGCATGAATC// SEQ ID NO: 3990
FCBBF30078600//CTTCAACAGTGCTTTTCCTT// SEQ ID NO: 3991
FCBBF30105080//CTGTGCACCCACTCTTTATT// SEQ ID NO: 3992
FCBBF30169870//TCCAGTATTTTCCACTTTGA// SEQ ID NO: 3993
FCBBF30225930//ACTATTTTATGGTCACGGCC// SEQ ID NO: 3994
FCBBF50000610//AGTTAACGTATCTGGCAAAG// SEQ ID NO: 3995
FEBRA20007820//GTTTCTCACTGTCCTGTTTT// SEQ ID NO: 3996
FEBRA20031280//ACTATTTTATGGTCACGGCC// SEQ ID NO: 3997
FEBRA20031810//TGCAATCATCTCTGTATCCC// SEQ ID NO: 3998
FEBRA20039260//GTCAGAACCCACTTCACATC// SEQ ID NO: 3999
FEBRA20046280//TCTCTGTCCTGTTGTCTAAG// SEQ ID NO: 4000
FEBRA20084750//TTAGCATGTACTGGGAAAGC// SEQ ID NO: 4001
FEBRA20182030//AAAACACAAAATGACACCCC// SEQ ID NO: 4002
HLUNG20041540//AAAGTTCCTCTGCATTCACC// SEQ ID NO: 4003
HLUNG20092530//TTTTCATCCCAGAGTTATTA// SEQ ID NO: 4004
KIDNE20084030//AGGGAATAACTTGCAGCTTG// SEQ ID NO: 4005
KIDNE20084800//GTAATGTAGGGAGACTGCCG// SEQ ID NO: 4006
KIDNE20134130//AATCCCCTCTTTTGTCTCAT// SEQ ID NO: 4007
KIDNE20182540//ACAGATAGCCTGGATTGAAA// SEQ ID NO: 4008
KIDNE20186170//TTGTATCTGAGCTGGGGTTT// SEQ ID NO: 4009
KIDNE20188630//CCCTACATATCTCTACCCAT// SEQ ID NO: 4010
LIVER20007750//TATTTAGAAACGCAGACCCC// SEQ ID NO: 4011
MESAN20021220//TAGAAGTCAACAAAAGGCAC// SEQ ID NO: 4012
MESAN20084150//TCCATAAGGCACAGATTTGA// SEQ ID NO: 4013
NT2NE20059210//ATAATGACAATGCCAGTAGT// SEQ ID NO: 4014
NT2NE20082130//TGAGGTACATCCAAATTAAA// SEQ ID NO: 4015
NT2NE20092950//ATGATTACTCGGTTTCCAGA// SEQ ID NO: 4016
NT2RP70031070//CAGTTAGTAGACAGACGGGG// SEQ ID NO: 4017
OCBBF20012520//TCTGCCTGTAGTTGCCATTA// SEQ ID NO: 4018
OCBBF20110210//AGGTGATAGGACTTTGTGCC// SEQ ID NO: 4019
OCBBF20110730//TTAGATGCTCCCTAAGGTCC// SEQ ID NO: 4020
OCBBF20155030//GCTAAAATCGTGCATCTGTA// SEQ ID NO: 4021
OCBBF20165900//AGTTTTGTATCTCCTTGTCA// SEQ ID NO: 4022
OCBBF20170350//TAAGATGGAGTTCAGGGGAG// SEQ ID NO: 4023
OCBBF20176650//GCACACAGGCAAATTCTAGT// SEQ ID NO: 4024
PLACE60006300//TTCTGTAATAAGGGCTGTCA// SEQ ID NO: 4025
PLACE60061370//TGTTCACAAATGGCATAAAA// SEQ ID NO: 4026
PROST20011160//CTACTAACTCAACCACGCAT// SEQ ID NO: 4027
PROST20041460//CCATTTACGTCACCTCTCTG// SEQ ID NO: 4028
PROST20065100//ACTATTTTATGGTCACGGCC// SEQ ID NO: 4029
PROST20075280//ACGTTGACTCTGATAGCCTG// SEQ ID NO: 4030
PROST20106060//AATTCTTTTGACATTGCTTG// SEQ ID NO: 4031
PROST20110120//GATAAATTCAGCAAGAGCAT// SEQ ID NO: 4032
SKMUS20091900//AACTCTGCACTCCATAACTG// SEQ ID NO: 4033
SMINT20024140//AAGCCTCTAAAAGTCAACAC// SEQ ID NO: 4034
SMINT20092160//TTAAACAAGTGAGCCTCAGA// SEQ ID NO: 4035
SPLEN20040780//TTTCCTGTTTGGTTAGTTTT// SEQ ID NO: 4036
SPLEN20110860//CTGACGGAAAACTTCTAATT// SEQ ID NO: 4037
SPLEN20177400//ATATCTGGTTGTTGGGTTTT// SEQ ID NO: 4038
TESTI20038240//GTCTGTCTTGATGGATTGGA// SEQ ID NO: 4039
TESTI20043130//AACTATCAGACTGCAAGAGC// SEQ ID NO: 4040
TESTI20046540//GGTAGCCAATAGCAAACAGG// SEQ ID NO: 4041
TESTI20047370//ACGTTGCATAATCCTCAGTC// SEQ ID NO: 4042
TESTI20057200//AGTCCCAGTCTCTAGTTCGG// SEQ ID NO: 4043
TESTI20057590//ACATTTTGGTATTGACACTT// SEQ ID NO: 4044
TESTI20113940//GTCAGTCCACCTTACTCTTT// SEQ ID NO: 4045
TESTI20149880//CAAACGATTACGACACAAAA// SEQ ID NO: 4046
TESTI20151800//CGTTCCTCAGGTAGCAAGAT// SEQ ID NO: 4047
TESTI20173050//ACATGGCTGAAGGTGATTTT// SEQ ID NO: 4048
TESTI20198600//TTTAGAAACATTGGCATCAG// SEQ ID NO: 4049
TESTI20257910//CTGCCTAGAGTAGAACAAAA// SEQ ID NO: 4050
TESTI20262940//CTCCCAATCTCAAACACAAG// SEQ ID NO: 4051
THYMU20046770//CTTCTGCCGAGTTTGTGTAA// SEQ ID NO: 4052
THYMU20058550//GATGCTGAGAAGGTGTTAGT// SEQ ID NO: 4053
THYMU20062520//AGTCTCAGGATGGGTAAAGG// SEQ ID NO: 4054
THYMU20062770//AGAGTTAAGAACCGAGGGAT// SEQ ID NO: 4055
THYMU20078240//CAAGCCAGGGAGATAGACAT// SEQ ID NO: 4056
THYMU20150190//TACTACAATGTGGGCTACGG// SEQ ID NO: 4057
TRACH20125620//CCACATTGTAAACAGTCCTT// SEQ ID NO: 4058
TRACH20149740//AGATACATTTTCCGTCAAGC// SEQ ID NO: 4059
TRACH20190460//CCAGAAGAGTAGCAAGAATT// SEQ ID NO: 4060
UTERU20045200//ATTCAACTAAAACAAAGCTG// SEQ ID NO: 4061
UTERU20064120//ACCCAGAAAAGAGATGAGAA// SEQ ID NO: 4062
UTERU20103200//CTGTTCCTGGCAAATAAGAG// SEQ ID NO: 4063
ADRGL20046760//ATGTGAAGGAATGATGTACT// SEQ ID NO: 4064
ASTRO20055530//GAATAATGAAGGGGACCAGA// SEQ ID NO: 4065
BRAMY20076130//CCTTTCATGTCTCAGTATTT// SEQ ID NO: 4066
CTONG20170940//ATACGTCAGAGGACACATGC// SEQ ID NO: 4067
FCBBF20033360//TCCGTAGCAGTAGAAACATC// SEQ ID NO: 4068
FCBBF30257370//CAGGTATGCTTGGAGTTTCA// SEQ ID NO: 4069
FCBBF5000165O//CGTGATTAGGAAGGGACAGT// SEQ ID NO: 4070
FEBRA20040290//CCCAAGAACGAAACAAAACT// SEQ ID NO: 4071
FEBRA20063720//AATAATGCCCACCTATAAAA// SEQ ID NO: 4072
FEBRA20098040//GAGGGGAATTGTCAGTACAC// SEQ ID NO: 4073
FEBRA20108580//TCATTTTGTCTAGTGCCCAT// SEQ ID NO: 4074
MESAN20021860//ACACATTCCCATCAATAGGT// SEQ ID NO: 4075
MESAN20067430//AGCTAAGGAGGTTTTCACAT// SEQ ID NO: 4076
NT2NE20045190//GGAATATGTTGGGCTAGTTA// SEQ ID NO: 4077
PROST20016760//AACTTCATCCATTCCAACTG// SEQ ID NO: 4078
SKNSH2000716O//TTAAACCAACATTGAGGAAA// SEQ ID NO: 4079
SMINT20006020//CTTGGTTGTCCCCTTTCTAG// SEQ ID NO: 4080
TESTI20059370//GGCTGACTTTTCTCCTACAG// SEQ ID NO: 4081
TESTI20103690//CCACTTTATTTCTCCTCCCT// SEQ ID NO: 4082
TESTI20254480//GTGGACACAACTTGCTTTAC// SEQ ID NO: 4083
THYMU10004280//GAGAGTCTGCCTAGCTGTGT// SEQ ID NO: 4084
THYMU20030460//GCCCATGTGAGTAGGTGTAG// SEQ ID NO: 4085
TRACH20090060//AGGGCCAACTTAAATCTCTG// SEQ ID NO: 4086
UTERU20041970//GATAAACCCCAAACATGAAA// SEQ ID NO: 4087
BRAMY20125360//GACAGACTAAAACGTTGAGC// SEQ ID NO: 4088
OCBBF20142290//CCAAGGAGAGTCAGTGACAG// SEQ ID NO: 4089
SKMUS20006790//TTCAAAAGCAGAGACTCCCT// SEQ ID NO: 4090
TESTI20030610//TGAACTCAGTACCAGGCTTG// SEQ ID NO: 4091
UTERU20026620//GAGATTCCCTAGTGGTGGTT// SEQ ID NO: 4092
[1698] The result of expression frequency analysis is shown in
Table 40. The clones not shown in the table contain clones whose
expression levels could not be measured because the levels were too
low or the sizes of the PCR products were different from the
expected. It was confirmed that the expression levels of IL-8 gene
used as a positive control gene were elevated.
[1699] The result obtained by the search for the genes whose
expression levels were altered depending on the presence of
TNF-.alpha. in culturing THP-1 cell, which is a human monocyte cell
line, showed that the clones whose expression levels were elevated
by twofold or more one or three hours after the stimulation (the
clones whose expression levels were 0.1 or lower both before and
after the stimulation were excluded), were TABLE-US-00066
ASTRO20055530, ASTRO20055930, ASTRO20088950, BRAMY20027390,
BRAMY20076130, BRAMY20118410, BRAMY20125360, BRAMY20237190,
BRCAN20001480, BRHIP10000720, CD34C20001750, CTONG20078340,
CTONG20085210, DFNES20063460, FCBBF20029280, FCBBF20033360,
FCBBF30078600, FEBRA20007820, FEBRA20031280, FEBRA20031810,
FEBRA20040290, HLUNG20041540, HLUNG20092530, MESAN20021860,
MESAN20067430, MESAN20084150, NT2NE20092950, NT2RP70031070,
OCBBF20012520, OCBBF20142290, OCBBF20165900, OCBBF20170350,
OCBBF20176650, PLACE60006300, PROST20011160, PROST20106060,
SPLEN20040780, SPLEN20110860, SPLEN20177400, TESTI20030610,
TESTI20043130, TESTI20059370, TESTI20254480, THYMU10004280,
THYMU20030460, THYMU20062520, THYMU20078240, THYMU20150190,
TRACH20090060, TRACH20125620, UTERU20026620, UTERU20045200,
UTERU20064120, UTERU20103200.
[1700] On the other hand, in particular cases where the expression
levels were relatively high in the unstimulated cells (the relative
value was 1 or higher), the clones whose expression levels were
decreased by twofold or more by the TNF-.alpha. stimulation (the
clones whose expression levels were increased 1 or 3 hours after
the stimulation were excluded) were TABLE-US-00067 BNGH420052350,
BRACE20052530, BRAMY20003880, CTONG20170940, FCBBF30022680,
FCBBF30225930, FCBBF30257370, FEBRA20046280, KIDNE20084030,
KIDNE20188630, NT2NE20082130, OCBBF20110210, PLACE60061370,
PROST20041460, PROST20075280, PROST20110120, SMINT20006020,
TESTI20046540, TESTI20057200, TESTI20113940, TESTI20257910,
TESTI20262940, TRACH20149740.
[1701] These clones were thus revealed to be involved in the
inflammation reaction induced by TNF-.alpha..
[1702] The result obtained by the search for the genes whose
expression levels were altered depending on co-culturing gastric
cancer cell line MKN45 with cag PAI positive Helicobacter pylori
(TN2), showed that the clones whose expression levels were elevated
by twofold or more (the clones whose expression levels were 0.1 or
lower both before and after the stimulation were excluded), were
TABLE-US-00068 BRAMY20028530, BRAMY20035380, OCBBF20170350,
PROST20011160, SKMUS20091900, SPLEN20040780, THYMU20078240,
TRACH20190460, UTERU20045200, UTERU20064120, ASTRO20055530,
CTONG20170940, FEBRA20040290, MESAN20067430, PROST20016760,
THYMU10004280, TRACH20090060, UTERU20041970, OCBBF20142290,
TESTI20030610.
[1703] Of these clones, the expression levels of BRAMY20035380,
SKMUS20091900, SPLEN20040780, UTERU20064120, CTONG20170940,
OCBBF20142290, TESTI20030610 were not increased by the co-culture
with the cagE mutant (TN2.DELTA.cagE). There may be the possibility
that the expression levels of the 7 clones are altered via the
NF-.kappa.B pathway. Among them, the expression levels of
OCBBF20142290, SPLEN20040780, TESTI20030610, UTERU20064120 were
also increased when human monocyte cell line THP-1 was stimulated
with TNF-.alpha..
[1704] On the other hand, in particular cases where the expression
levels were relatively high in the unstimulated cells (the relative
value was 1 or higher), the clones whose expression levels were
decreased by twofold or more in the presence of Helicobacter pylori
were TABLE-US-00069 ASTRO20088950, BRACE20052530, BRAMY20003880,
BRAMY20027390, BRAMY20036530, BRAMY20118410, BRHIP20000210,
FCBBF20032930, FCBBF30022680, FCBBF30169870, FEBRA20182030,
KIDNE20182540, LIVER20007750, MESAN20021220, NT2NE20059210,
NT2NE20082130, OCBBF20155030, PROST20065100, PROST20075280,
SPLEN20110860, TESTI20057200, TESTI20113940, TESTI20149880,
TESTI20151800, TESTI20198600, TESTI20257910, THYMU20046770,
THYMU20058550, THYMU20150190, FCBBF20033360, FCBBF30257370,
FEBRA20098040, SMINT20006020.
[1705] These clones are involved in gastritis or gastroduodenal
ulcer. TABLE-US-00070 TABLE 3 Clone ID CD34C D30ST D60ST D90ST
ASTRO20010290 0 55.437 0 0 BRAMY20036530 0 33.144 0 0 BRAMY20043630
0 0 0 13.575 BRAMY20089770 0 0 0 63.803 BRAMY20190550 0 0 0 31.089
CD34C20001750 100 0 0 0 FCBBF20066340 0 0 0 76.503 FEBRA20040290 0
0 0 14.912 HLUNG20015180 0 0 0 8.491 HLUNG20041590 0 0 0 18.349
HLUNG20052300 0 36.241 0 0 KIDNE20084040 0 0 0 65.916 MESAN20021860
0 0 0 56.046 MESAN20027240 0 0 0 33.731 NTONG20055200 0 0 0 19.731
PROST20016760 0 0 0 15.442 PUAEN10001640 0 34.074 0 0 SMINT20006020
0 7.702 0 9.021 SMINT20028840 0 68.605 0 0 SMINT20035050 0 9.417 0
11.029 SPLEN20181570 81.506 0 0 0 TESTI20064530 0 0 77.29 0
TESTI20210030 0 0 0 90.471 THYMU20029830 0 42.091 0 0 THYMU20139160
0 0 0 3.486 TRACH20051590 0 0 0 75.217
[1706] TABLE-US-00071 TABLE 4 Clone ID NT2RM NT2RP NT2RI NT2NE
ADRGL20023920 0 6.69 0 0 ASTRO20009140 0 0 13.389 0 BNGH420077980 0
0 20.754 0 BNGH420086030 0 0 0 13.322 BRACE20062580 0 0 3.585 2.717
BRACE20079370 0 0 9.312 14.111 BRACE20215410 0 0 27.196 0
BRAMY20003540 0 0 3.208 4.861 BRAMY20043630 0 0 2.408 0
BRAMY20076130 0 0 6.601 0 BRAMY20095080 0 0 25.606 0 BRAMY20227860
0 2.798 6.17 3.596 BRAWH20082550 0 0 0 9.738 BRHIP10001040 0 0 0
2.323 BRSSN20005610 0 22.393 0 0 CTONG20027660 0 0 50.642 0
CTONG20044230 0 0 50.642 0 CTONG20066110 0 0 19.131 0 CTONG20079590
0 14.297 29.102 0 CTONG20084660 0 0 2.553 0 CTONG20133720 0 8.861 0
9.111 CTONG20165750 0 9.056 0 0 CTONG20188080 0 10.319 0 0
FCBBF20023490 0 7.376 0 7.583 FCBBF20033360 0 0 5.015 0
FCBBF20059660 0 0 0 66.235 FCBBF20070950 0 0 15.367 0 FCBBF30004340
0 0 0 8.778 FCBBF30095410 0 79.235 0 0 FCBBF30125460 0 0 0 9.321
FCBBF30179180 0 0 56.418 0 FCBBF30236670 0 1.325 4.494 2.724
FCBBF30257370 0 19.522 0 0 FCBBF50000610 0 0 56.418 0 FCBBF50001650
0 0 0 22.181 FEBRA20038330 0 16.124 0 0 FEBRA20039260 0 7.162 2.43
0 FEBRA20063720 0 12.258 0 0 FEBRA20090220 0 4.602 3.122 4.732
FEBRA20150420 0 0 33.26 0 HEART10001490 0 0 9.27 0 HLUNG20032460 0
0 0 21.278 HLUNG20041590 0 0 0 4.932 KIDNE20089870 0 0 0 4.145
MESAN20016270 0 0 39.208 0 MESAN20021860 0 0 0 7.532 MESAN20060430
0 0 24.385 0 MESAN20067430 0 0 0 9.568 NT2NE20018740 0 0 0 100
NT2NE20018890 0 0 0 100 NT2NE20021860 0 0 0 100 NT2NE20026200 0 0
0.808 2.449 NT2NE20026510 0 0 0 100 NT2NE20028700 0 0 0 22.223
NT2NE20033150 0 0 0 50.133 NT2NE20037050 0 0 0 100 NT2NE20038870 0
0 0 100 NT2NE20039210 0 0 0 100 NT2NE20042550 0 0 0 59.083
NT2NE20045190 0 0 5.05 15.306 NT2NE20047870 0 0 0 100 NT2NE20053230
0 0 0 100 NT2NE20053950 0 20.953 0 21.544 NT2NE20059210 0 0 0 100
NT2NE20059680 0 0 0 100 NT2NE20060750 0 0 0 100 NT2NE20061030 0
39.18 0 40.284 NT2NE20062880 0 0 0 100 NT2NE20064780 0 0 0 100
NT2NE20066590 0 0 0 100 NT2NE20069580 0 0 0 59.083 NT2NE20070520 0
0 0 100 NT2NE20073650 0 0 0 100 NT2NE20077250 0 0 0 100
NT2NE20077270 0 0 0 100 NT2NE20077860 0 0 0 100 NT2NE20079670 0 0 0
100 NT2NE20080770 0 0 0 100 NT2NE20082130 0 0 0 38.09 NT2NE20082600
0 0 0 66.235 NT2NE20086070 0 0 0 100 NT2NE20087270 0 0 0 100
NT2NE20087850 0 0 0 100 NT2NE20088030 0 0 0 60.425 NT2NE20092950 0
20.298 0 20.87 NT2NE20095230 0 0 0 55.188 NT2NE20104000 0 0 0 100
NT2NE20107810 0 0 0 100 NT2NE20108420 0 0 0 45.407 NT2NE20111190 0
0 0 61.289 NT2NE20112210 0 0 0 26.669 NT2NE20114850 0 0 0 100
NT2NE20117580 0 0 0 100 NT2NE20119980 0 0 0 100 NT2NE20123610 0 0 0
100 NT2NE20124570 0 0 0 100 NT2NE20126030 0 0 0 100 NT2NE20127900 0
0 16.514 25.025 NT2NE20140130 0 0 0 100 NT2NE20140280 0 0 0 100
NT2NE20141040 0 0 0 36.013 NT2NE20145250 0 0 0 100 NT2NE20146510 0
0 0 100 NT2NE20148690 0 0 0 67.567 NT2NE20149500 0 0 0 100
NT2NE20150610 0 0 0 100 NT2NE20152620 0 0 0 100 NT2NE20153620 0 0 0
60.858 NT2NE20155650 0 0 0 100 NT2NE20157120 0 0 0 100
NT2NE20165190 0 0 0 100 NT2NE20167660 0 0 0 100 NT2NE20173970 0 0 0
100 NT2NE20177210 0 0 0 43.734 NT2NE20181760 0 0 0 100
NT2NE20181800 0 0 0 46.215 NT2NE20184720 0 0 0 100 NT2RI20016240 0
0 100 0 NT2RI20021200 0 0 8.844 0 NT2RI20033920 0 0 100 0
NT2RI20093010 0 0 100 0 NT2RP70001120 0 32.573 0 0 NT2RP70001730 0
15.462 0 0 NT2RP70003110 0 24.333 0 0 NT2RP70012830 0 5.639 0 5.798
NT2RP70022820 0 66.955 0 0 NT2RP70027790 0 60.194 0 0 NT2RP70029780
0 100 0 0 NT2RP70030840 0 100 0 0 NT2RP70031070 0 100 0 0
NT2RP70031340 0 100 0 0 NT2RP70031480 0 100 0 0 NT2RP70035110 0
23.442 0 0 NT2RP70046410 0 64.358 0 0 NT2RP70049610 0 100 0 0
NT2RP70056290 0 100 0 0 NT2RP70056690 0 100 0 0 NT2RP70057500 0
13.6 0 0 NT2RP70064570 0 60.194 0 0 NT2RP70074800 0 100 0 0
NT2RP70075300 0 6.726 0 0 NT2RP70075800 0 100 0 0 NT2RP70080150 0
100 0 0 NT2RP70084540 0 100 0 0 NT2RP70087140 0 7.444 15.153 7.654
NT2RP70090870 0 17.122 11.617 0 OCBBF20001780 0 0 15.351 0
OCBBF20009820 84.348 0 0 0 OCBBF20142290 0 0 0 14.577 OCBBF20155030
0 49.439 0 0 OCBBF20175360 0 0 0 20.881 OCBBF20177540 0 25.509 0 0
OCBBF20177910 0 0 23.505 0 PLACE60054820 0 0 20.089 0 PLACE60061370
0 18.07 0 0 PLACE60073090 0 10.617 0 0 PLACE60162100 0 0 0 37.629
PROST20011800 0 0 0 50.542 PROST20045700 0 0 0 44.59 PROST20078710
0 0 0 33.633 PROST20094000 0 0 18.34 0 PUAEN10000650 0 3.375 0 0
PUAEN10001640 0 5.216 3.539 0 SKNMC20006350 0 2.005 2.041 4.124
SMINT20016150 0 49.972 0 0 SMINT20030740 0 5.712 0 0 SMINT20035510
0 0 28.984 0 SMINT20039050 0 0 18.576 9.383 SMINT20047290 0 39.6 0
0 SPLEN20063250 0 8.081 8.225 8.309 SPLEN20117580 0 0 0 24.462
SPLEN20125230 0 0 21.559 0 TESTI20030610 0 0 0 12.205 TESTI20043910
0 0 0 45.963 TESTI20066280 0 0 0 30.676 TESTI20067480 0 8.861 0 0
TESTI20105130 0 0 0 2.5 TESTI20106170 0 13.104 0 0 TESTI20143180 0
0 62.741 0 TESTI20221790 0 0 39.167 0 TESTI20254090 0 0 0 19.063
TESTI20274960 0 0 38.685 0 THYMU10004280 0 3.573 0 0 THYMU20007020
0 0 71.017 0 THYMU20104480 0 0 29.694 0 THYMU20139160 0 1.822 0.618
0 TRACH20026640 0 0 7.476 0 UTERU10001060 0 0 19.967 0
UTERU20026620 0 10.41 0 10.703 UTERU20079240 0 0 0 19.734
UTERU20083020 0 7.182 0 0 UTERU20102260 0 0 0 23.706 UTERU20132620
0 48.06 0 0
[1707] TABLE-US-00072 TABLE 5 Clone ID BEAST TBAES CTONG20070780 0
97.283 CTONG20084660 0 89.108 HLUNG20045340 0 85.362 TESTI20047370
0 71.55
[1708] TABLE-US-00073 TABLE 6 Clone ID CERVX TCERX SMINT20030740 0
65.795
[1709] TABLE-US-00074 TABLE 7 Clone ID COLON TCOLN UTERU2004037
68.149 0
[1710] TABLE-US-00075 TABLE 8 Clone ID NESOP TESOP HLUNG20015180
51.695 0 NESOP20004520 100 0 NESOP20005040 100 0 TESOP10000350 0
86.127 TESOP10001600 0 100 THYMU20071120 0 81.712
[1711] TABLE-US-00076 TABLE 9 Clone ID KIDNE TKIDN ASTRO20009140
19.518 0 ASTRO20027330 0 30.903 ASTRO20055930 0 36.981
BGGI120010750 4.532 0 BNGH420074600 0 11.358 BRACE20050870 0 15.884
BRACE20054480 29.719 0 BRACE20062580 2.613 0 BRACE20219360 59.494 0
BRAMY20003540 4.676 0 BRAMY20003880 16.882 41.527 BRAMY20043630
3.51 0 BRAMY20055760 0 65.196 BRAMY20125360 0 32.672 BRAMY20190550
0 19.772 BRAMY20204270 3.618 0 BRAMY20227860 0 4.255 BRAWH20014590
0 23.509 BRAWH20093070 0 14.759 BRHIP10001040 0 5.496 CTONG20033750
59.93 0 CTONG20039370 59.93 0 CTONG20045500 59.93 0 CTONG20079590 0
17.392 FCBBF20023490 14.59 0 FCBBF30004340 0 10.386 FCBBF30106950 0
69.888 FCBBF30115230 0 69.888 FCBBF30169280 0 38.857 FCBBF30225930
0 50.898 FCBBF30282020 0 53.714 FEBRA20038330 0 6.538 FEBRA20039260
7.084 0 FEBRA20040290 7.711 0 FEBRA20082660 0 77.359 FEBRA20121200
0 63.078 FEBRA20170240 0 63.078 HEART10001490 20.269 0
HLUNG20041590 4.744 0 HLUNG20068120 11.84 0 HLUNG20072450 3.599 0
HLUNG20083480 0 15.004 HLUNG20083960 18.946 0 KIDNE20011600 100 0
KIDNE20016360 59.589 0 KIDNE20024380 100 0 KIDNE20027980 100 0
KIDNE20080690 5.861 0 KIDNE20081170 100 0 KIDNE20083150 100 0
KIDNE20083620 100 0 KIDNE20084030 40.03 0 KIDNE20084040 34.084 0
KIDNE20084730 100 0 KIDNE20084800 100 0 KIDNE20086490 87.61 0
KIDNE20086660 47.013 0 KIDNE20086970 100 0 KIDNE20087880 28.683 0
KIDNE20088240 100 0 KIDNE20089870 3.987 0 KIDNE20091090 100 0
KIDNE20094260 100 0 KIDNE20094670 59.494 0 KIDNE20095530 100 0
KIDNE20133460 100 0 KIDNE20133880 100 0 KIDNE20134130 65.363 0
KIDNE20134890 100 0 KIDNE20137310 100 0 KIDNE20138450 38.971 0
KIDNE20140870 22.93 0 KIDNE20141120 100 0 KIDNE20141700 100 0
KIDNE20142680 100 0 KIDNE20142680 100 0 KIDNE20142900 31.732 0
KIDNE20143200 100 0 KIDNE20147170 100 0 KIDNE20148080 100 0
KIDNE20149780 60.365 0 KIDNE20150730 100 0 KIDNE20152440 100 0
KIDNE20154330 100 0 KIDNE20154830 100 0 KIDNE20155980 100 0
KIDNE20157100 100 0 KIDNE20160360 100 0 KIDNE20160960 100 0
KIDNE20163710 100 0 KIDNE20165390 100 0 KIDNE20169180 100 0
KIDNE20170400 19.556 0 KIDNE20173150 100 0 KIDNE20173430 36.673 0
KIDNE20176030 100 0 KIDNE20181670 100 0 KIDNE20182540 100 0
KIDNE20186170 100 0 KIDNE20188630 100 0 KIDNE20189890 100 0
KIDNE20189960 100 0 KIDNE20191870 100 0 MESAN20038520 0 11.358
MESAN20041380 0 53.625 OCBBF20016390 0 23.211 OCBBF20142290 0 8.623
OCBBF20174890 32.241 0 PLACE60061370 0 21.981 PLACE60073090 10.501
0 PLACE60181870 49.921 0 PROST20016760 3.992 9.82 PUAEN10000650
6.676 0 SMINT20039050 0 11.102 SMINT20089210 0 12.885 SPLEN20017610
42.429 0 SPLEN20024930 0 22.541 SPLEN20057830 0 35 SPLEN20063250
3.996 0 SPLEN20126110 50.05 0 SPLEN20135030 31.695 0 SPLEN20136700
0 39.807 TESTI20070740 0 75.118 TESTI20262150 40.96 0 THYMU20009500
0 24.928 THYMU20019260 0 36.869 THYMU20157620 0 19.973
TKIDN10000620 0 100 TKIDN10001710 0 100 TKIDN10001920 0 36.869
TRACH20011010 10.647 0 UMVEN10001380 0 4.196
[1712] TABLE-US-00077 TABLE 10 Clone ID LIVER TLIVE CTONG20069320
20.862 0 FCBBF30236670 3.257 0 FEBRA20038220 77.547 0 FEBRA20039260
8.806 0 KIDNE20087880 71.317 0 LIVER20006260 100 0 LIVER20007690
85.922 0 LIVER20007750 100 0 LIVER20010510 100 0 LIVER20010760 100
0 LIVER20010990 100 0 LIVER20011640 100 0 LIVER20013890 100 0
LIVER20026440 100 0 LIVER20030650 100 0 LIVER20032340 100 0
LIVER20038000 100 0 LIVER20040740 100 0 LIVER20055270 100 0
MESAN20027240 21.684 0 NT2RI20021200 16.028 0 SKMUS20006790 6.063 0
TESTI20035330 22.045 0 THYMU10004280 8.787 4.346 THYMU20029830
31.692 0
[1713] TABLE-US-00078 TABLE 11 Clone ID HLUNG TLUNG HLUNG20052300
23.611 0 SMINT20035050 6.135 0 HLUNG20041590 10.207 0 PROST20016760
8.589 0 BRAMY20043630 15.102 0 HLUNG20015180 4.723 0 THYMU20139160
1.939 0 HLUNG20020850 67.488 0 HLUNG20032460 44.037 0 BRAMY20204270
7.785 0 BRAMY20001510 5.948 0 BRAMY20227860 1.488 0 CTONG20029030
28.504 0 CTONG20168460 76.291 0 CTONG20186290 61.67 0 FEBRA20039260
7.62 0 FEBRA20078800 33.686 0 FEBRA20163980 38.327 0 HCHON20000870
23.288 0 HLUNG20008460 67.54 0 HLUNG20009260 100 0 HLUNG20009550
100 0 HLUNG20010130 100 0 HLUNG20011260 100 0 HLUNG20011440 100 0
HLUNG20011460 76.577 0 HLUNG20012140 100 0 HLUNG20014590 36.045 0
HLUNG20015070 17.804 0 HLUNG20020500 100 0 HLUNG20021450 68.006 0
HLUNG20023030 100 0 HLUNG20024050 100 0 HLUNG20025620 100 0
HLUNG20028110 76.618 0 HLUNG20029420 100 0 HLUNG20029490 81.173 0
HLUNG20030420 100 0 HLUNG20030490 100 0 HLUNG20030610 100 0
HLUNG20031620 80.237 0 HLUNG20033060 36.529 0 HLUNG20033310 100 0
HLUNG20033350 100 0 HLUNG20034970 79.349 0 HLUNG20037140 100 0
HLUNG20037160 100 0 HLUNG20037780 44.761 0 HLUNG20038330 100 0
HLUNG20041540 100 0 HLUNG20042730 100 0 HLUNG20045340 7.67 0
HLUNG20047070 100 0 HLUNG20050760 100 0 HLUNG20051330 100 0
HLUNG20054790 100 0 HLUNG20055240 100 0 HLUNG20056560 75.961 0
HLUNG20057380 100 0 HLUNG20059240 100 0 HLUNG20060670 100 0
HLUNG20063700 100 0 HLUNG20065700 62.8 0 HLUNG20065990 100 0
HLUNG20067810 100 0 HLUNG20068120 50.947 0 HLUNG20069350 100 0
HLUNG20070410 100 0 HLUNG20072100 54.241 0 HLUNG20072190 79.349 0
HLUNG20072450 7.744 0 HLUNG20074330 100 0 HLUNG20079310 100 0
HLUNG20081390 66.429 0 HLUNG20081530 100 0 HLUNG20082350 100 0
HLUNG20083330 100 0 HLUNG20083480 13.123 0 HLUNG20083840 100 0
HLUNG20083960 40.76 0 HLUNG20084790 100 0 HLUNG20085210 50.993 0
HLUNG20088750 100 0 HLUNG20092530 100 0 HLUNG20093030 100 0
HLUNG20094130 75.987 0 KIDNE20142900 68.268 0 PROST20052850 57.701
0 SKNMC20006350 2.134 0 SPLEN20012450 25.695 0 TESTI20057590 17.804
0 TESTI20061200 29.123 0 TESTI20067480 18.856 0 TESTI20116050
30.168 0 THYMU10004280 7.603 0 THYMU20010180 79.349 0 TRACH20011010
22.907 0 UTERU20016580 43.64 0 UTERU20127030 66.318 0
[1714] TABLE-US-00079 TABLE 12 Clone ID NOVAR TOVAR KIDNE20089870
91.868 0 NT2RP70075300 76.633 0 TESTI20132310 94.177 0
[1715] TABLE-US-00080 TABLE 13 Clone ID STOMA TSTOM BNGH420087430 0
91.629 BRAMY20227860 1.35 0 BRAWH20027250 42.096 0 CTONG20174440
26.346 0 FEBRA20090220 4.442 0 PUAEN10000650 13.031 0 SMINT20023110
72.094 0 SMINT20030740 5.514 0 SMINT20045890 34.092 0 SPLEN20048800
2.011 0 SPLEN20139360 79.641 0 TESTI20063410 28.273 0 TESTI20150920
33.158 0 TRACH20026640 21.272 0 UTERU20041970 0 72.886
[1716] TABLE-US-00081 TABLE 14 Clone ID UTERU TUTER ADRGL20020290
21.538 0 BRACE20038920 10.185 0 BRAMY20091230 39.224 0
BRAMY20093490 62.465 0 BRAMY20227860 2.268 0 BRHIP20005060 61.644 0
CTONG20069320 18.336 0 CTONG20083430 62.039 0 FCBBF30005360 41.409
0 FCBBF30257370 21.099 0 FEBRA20038330 5.808 0 FEBRA20039260 7.74 0
FEBRA20040260 43.146 0 FEBRA20078180 31.447 0 FEBRA20087550 10.505
0 HLUNG20015070 9.042 0 HLUNG20015180 7.196 0 MESAN20007110 50.674
0 MESAN20067430 20.114 0 MESAN20095800 14.162 0 NT2RP70057500
14.698 0 SKMUS20008730 2.775 0 SKNMC20006350 1.084 0 SMINT20035050
3.116 0 SMINT20045890 19.084 0 SPLEN20073880 30.142 0 SPLEN20076470
17.567 0 SPLEN20118050 33.583 0 TESTI20030610 12.829 0
TESTI20035330 9.688 0 TESTI20057590 9.042 0 TESTI20059080 9.096 0
TESTI20105130 0 57.51 THYMU10004280 3.861 0 THYMU20139160 1.969
21.546 UTERU10001060 31.804 0 UTERU10001870 100 0 UTERU20000230
34.999 0 UTERU20000950 3.88 0 UTERU20011760 100 0 UTERU20013890 100
0 UTERU20016580 22.164 0 UTERU20026620 33.752 0 UTERU20027360 100 0
UTERU20029930 72.842 0 UTERU20031350 100 0 UTERU20035770 100 0
UTERU20040150 100 0 UTERU20040370 6.264 0 UTERU20040390 100 0
UTERU20040730 100 0 UTERU20041630 100 0 UTERU20041970 6.578 0
UTERU20045200 62.039 0 UTERU20051790 100 0 UTERU20064120 100 0
UTERU20065470 50.58 0 UTERU20079240 20.742 0 UTERU20083020 7.762 0
UTERU20086530 100 0 UTERU20087070 100 0 UTERU20087850 100 0
UTERU20089300 27.655 0 UTERU20089390 17.567 0 UTERU20089620 100 0
UTERU20090940 100 0 UTERU20091470 100 0 UTERU20094830 100 0
UTERU20095100 39.739 0 UTERU20099040 100 0 UTERU20099510 100 0
UTERU20101150 100 0 UTERU20102260 24.918 0 UTERU20103040 100 0
UTERU20103200 51.815 0 UTERU20104310 100 0 UTERU20106510 100 0
UTERU20121140 100 0 UTERU20122520 51.33 0 UTERU20125810 100 0
UTERU20127030 33.682 0 UTERU20127150 62.412 0 UTERU20128560 36.129
0 UTERU20132620 51.94 0 UTERU20134830 100 0 UTERU20139760 100 0
UTERU20140010 100 0 UTERU20167570 100 0 UTERU20168960 100 0
UTERU20169020 100 0 UTERU20173030 100 0 UTERU20176230 72.842 0
UTERU20177150 100 0 UTERU20181270 100 0 UTERU20185220 100 0
UTERU20188670 100 0 UTERU20188840 40.303 0
[1717] TABLE-US-00082 TABLE 15 Clone ID NTONG CTONG ADRGL20023920
13.989 0 BRACE20038920 0 24.929 BRACE20050870 0 34.54 BRACE20061620
63.015 0 BRAMY20036530 21.217 0 BRAMY20076130 0 6.434 BRAMY20204270
0 2.419 BRAMY20267780 0 4.633 BRCAN10001680 14.71 0 CTONG10000090 0
87.752 CTONG20000340 0 100 CTONG20002790 0 100 CTONG20004110 0 100
CTONG20004520 0 100 CTONG20007660 0 100 CTONG20008190 0 100
CTONG20008460 0 100 CTONG20015240 0 100 CTONG20017490 0 100
CTONG20020660 0 100 CTONG20020950 0 100 CTONG20027660 0 49.358
CTONG20029030 0 44.292 CTONG20030280 0 100 CTONG20031150 0 100
CTONG20031890 0 62.139 CTONG20032930 0 29.763 CTONG20033500 0 100
CTONG20033610 0 57.263 CTONG20033750 0 40.07 CTONG20035240 0 55.786
CTONG20036800 0 100 CTONG20036990 0 100 CTONG20039370 0 40.07
CTONG20041150 0 100 CTONG20041260 0 100 CTONG20042640 0 100
CTONG20044230 0 49.358 CTONG20044870 0 74.685 CTONG20045500 0 40.07
CTONG20046690 0 100 CTONG20049480 0 100 CTONG20050490 0 100
CTONG20051100 0 100 CTONG20051450 0 100 CTONG20052780 0 100
CTONG20053990 0 100 CTONG20055670 0 100 CTONG20055850 0 24.814
CTONG20056150 0 51.203 CTONG20057750 0 100 CTONG20057950 0 54.423
CTONG20059130 0 72.445 CTONG20060040 0 72.825 CTONG20061290 0 100
CTONG20062730 0 100 CTONG20063770 0 62.139 CTONG20063930 0 28.37
CTONG20065240 0 100 CTONG20065680 0 100 CTONG20066110 0 37.292
CTONG20068360 0 100 CTONG20069320 0 11.22 CTONG20069420 0 42.813
CTONG20070090 0 100 CTONG20070720 0 7.689 CTONG20070780 0 2.717
CTONG20070910 0 100 CTONG20071040 0 32.374 CTONG20071680 0 49.582
CTONG20072930 0 100 CTONG20073990 0 100 CTONG20074000 0 100
CTONG20074170 0 55.786 CTONG20074740 0 100 CTONG20076230 0 100
CTONG20076810 0 100 CTONG20077760 0 100 CTONG20078340 0 74.685
CTONG20079590 0 9.455 CTONG20080140 0 27.673 CTONG20081840 0 100
CTONG20083430 0 37.961 CTONG20083980 0 100 CTONG20084020 0 100
CTONG20084660 0 2.488 CTONG20085210 0 27.762 CTONG20133720 18.528
46.879 CTONG20165590 0 100 CTONG20165750 0 11.978 CTONG20166580 0
100 CTONG20167750 0 100 CTONG20168240 37.367 11.818 CTONG20168460 0
23.709 CTONG20169040 0 100 CTONG20169530 0 100 CTONG20170940 0
89.253 CTONG20174290 0 100 CTONG20174580 0 100 CTONG20176040 0 100
CTONG20179390 0 100 CTONG20179890 0 100 CTONG20179980 0 100
CTONG20180620 0 100 CTONG20180690 0 100 CTONG20181350 0 100
CTONG20183430 0 55.786 CTONG20183830 0 22.718 CTONG20184130 0 100
CTONG20184830 0 100 CTONG20186140 0 100 CTONG20186290 0 38.33
CTONG20186370 0 39.387 CTONG20186520 0 100 CTONG20186550 0 100
CTONG20188080 43.151 6.824 CTONG20189000 0 100 CTONG20190290 0 100
CTONG20190630 0 100 FCBBF20070950 0 14.977 FCBBF30001100 0 24.477
FCBBF30175350 32.34 10.228 FCBBF40005000 0 20.766 FEBRA20027070
26.269 0 FEBRA20038330 0 3.554 FEBRA20039260 7.487 0 FEBRA20040290
0 2.578 FEBRA20046200 0 16.309 FEBRA20063720 0 8.106 FEBRA20078800
0 10.469 FEBRA20090220 0 12.173 HCHON20000870 0 7.237 HLUNG20068120
25.03 0 MESAN20008150 0 38.598 MESAN20027900 0 17.599 NT2NE20153620
0 39.142 NT2RP70001730 0 4.09 NT2RP70012830 0 3.729 NT2RP70027790 0
39.806 NT2RP70057500 0 8.993 NT2RP70064570 0 39.806 NT2RP70090870
35.801 0 NTONG20002230 50.815 0 NTONG20005310 100 0 NTONG20017620
29.697 0 NTONG20029850 100 0 NTONG20031580 100 0 NTONG20032100 100
0 NTONG20034540 67.622 0 NTONG20035150 80.903 0 NTONG20043080 100 0
NTONG20048440 100 0 NTONG20049180 63.818 20.184 NTONG20053630 100 0
NTONG20053730 100 0 NTONG20053910 100 0 NTONG20055200 10.784 3.411
NTONG20058010 100 0 NTONG20058220 100 0 OCBBF20110730 0 11.1
OCBBF20177540 0 16.869 OCBBF20177910 0 22.909 PROST20016760 0 2.669
PROST20042700 0 33.088 PROST20050390 0 30.175 PROST20063430 50.958
0 PROST20130320 0 11.979 PUAEN10000650 7.056 0 PUAEN10001640 0
13.798 PUAEN20003120 0 19.799 SKMUS20006790 5.155 0 SKNMC20006350 0
3.316 SKNSH20007160 0 9.506 SMINT20030740 0 5.666 SMINT20035510 0
28.25 SMINT20089210 0 7.005 SPLEN20024930 0 12.254 SPLEN20040780 0
20.5 SPLEN20063250 0 8.016 SPLEN20181570 0 4.523 SPLEN20187490 0
23.141 TESTI20047370 0 1.998 TESTI20057880 0 15.357 TESTI20064530 0
10.734 TESTI20079980 0 8.166 TESTI20105130 0 4.825 TESTI20118460
63.366 0 TESTI20121040 0 17.698 TESTI20197290 0 62.139
THYMU10004280 0 2.363 THYMU20030460 14.321 4.53 THYMU20055460 0
10.818 THYMU20089900 0 37.939 THYMU20121040 0 54.423 THYMU20139160
1.905 4.82 THYMU20145990 0 37.385 TRACH20011010 0 28.476
TRACH20090060 0 6.234 UTERU20000230 0 21.416 UTERU20000950 0 2.374
UTERU20016580 0 13.562 UTERU20045200 0 37.961 UTERU20083020 15.017
0
[1718] TABLE-US-00083 TABLE 16 Clone ID FCBBF FEBRA OCBBF BRACE
BRALZ BRAMY BRAWH BRCAN BRCOC BRHIP BRSSN BRSTN BRTHA ADRGL- 0 0 0
0 0 12.942 0 0 0 0 0 0 0 20020290 ADRGL- 0 0 0 0 0 21.897 0 0 0
22.674 0 0 0 20021910 ADRGL- 0 0 0 4.505 0 0 0 0 0 0 0 0 0 20023920
ADRGL- 8.812 35.914 0 0 0 0 0 0 0 0 0 0 0 20046760 ADRGL- 0 0 0 0 0
0 0 28.364 0 0 0 0 0 20062330 ADRGL-0 0 0 0 0 0 0 28.364 0 0 0 0 0
20079060 ASTRO- 0 0 0 0 0 0 21.998 0 0 0 0 0 0 20009140 ASTRO- 0 0
0 0 0 38.79 0 0 0 0 0 0 0 20020240 ASTRO- 0 0 25.981 0 0 0 0 0 0
17.083 0 0 0 20027330 ASTRO- 0 0 0 0 0 0 0 0 0 0 0 49.891 0
20047510 ASTRO- 0 10.089 28.982 0 0 9.201 0 0 0 0 0 0 0 20055530
ASTRO- 0 0 0 0 0 0 0 38.844 0 0 0 0 0 20055570 ASTRO- 31.867 0 0 0
0 0 0 0 0 0 0 0 0 20055930 ASTRO- 0 0 0 0 0 0 0 0 0 0 33.707 0 0
20090680 BGGI- 4.804 0 0 0 0 0 0 0 0 0 0 0 0 120010750 BNGH- 0 0 0
10.084 0 0 0 0 0 0 0 0 0 420021680 BNGH- 0 0 0 0 0 0 0 0 0 0 0 0
52.181 420023870 BNGH- 8.889 0 0 0 0 0 0 0 0 0 0 0 0 420059680
BNGH- 4.894 0 0 0 0 12.127 0 0 0 0 0 0 0 420074600 BNGH- 0 0 0 0 0
8.414 0 8.433 0 0 0 0 0 420086030 BRACE- 0 0 0 55.676 0 0 30.722 0
0 0 0 0 0 10000510 BRACE- 0 0 0 29.513 0 0 48.856 0 0 0 0 0 0
20003310 BRACE- 0 0 0 38.94 0 0 0 0 0 0 61.06 0 0 20007330 BRACE- 0
0 0 100 0 0 0 0 0 0 0 0 0 20009050 BRACE- 0 0 0 100 0 0 0 0 0 0 0 0
0 20014450 BRACE- 43.768 0 0 56.232 0 0 0 0 0 0 0 0 0 20017790
BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0 20018810 BRACE- 0 0 0 50.035 0 0
0 0 0 49.965 0 0 0 20025820 BRACE- 0 20.132 9.638 6.346 0 12.24 0 0
0 0 0 0 0 20038920 BRACE- 6.844 0 26.708 8.793 0 0 0 0 0 0 0 0 0
20050870 BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0 20051600 BRACE- 0 0 0
100 0 0 0 0 0 0 0 0 0 20051930 BRACE- 0 0 0 100 0 0 0 0 0 0 0 0 0
20052430 BRACE- 0 0 0 19.237 0 0 0 0 0 0 0 0 80.763 20052530 BRACE-
0 0 0 26.402 0 0 0 25.519 0 26.365 0 0 0 20054080 BRACE- 0 0 0
40.468 0 0 0 0 0 0 0 0 0 20054480
[1719] TABLE-US-00084 TABLE 17 BRACE20054600 0 0 0 100 0 0 0 0 0 0
0 0 0 BRACE20055560 0 0 0 100 0 0 0 0 0 0 0 0 0 BRACE20057870 0 0 0
100 0 0 0 0 0 0 0 0 0 BRACE20059110 0 0 0 100 0 0 0 0 0 0 0 0 0
BRACE20059810 0 0 0 100 0 0 0 0 0 0 0 0 0 BRACE20061620 0 0 0
20.295 0 0 0 0 0 0 0 0 0 BRACE20062580 1.385 13.17 0 3.558 2.709 0
2.945 1.72 2.655 0 5.58 0 0 BRACE20063540 0 23.259 0 21.996 33.485
0 0 21.26 0 0 0 0 0 BRACE20065470 0 0 0 100 0 0 0 0 0 0 0 0 0
BRACE20066360 0 0 60.297 39.703 0 0 0 0 0 0 0 0 0 BRACE20068710 0 0
0 100 0 0 0 0 0 0 0 0 0 BRACE20069000 0 0 0 11.616 0 0 0 0 0 0 0 0
0 BRACE20069110 0 0 0 100 0 0 0 0 0 0 0 0 0 BRACE20069440 0 0 0 100
0 0 0 0 0 0 0 0 0 BRACE20079200 0 0 0 100 0 0 0 0 0 0 0 0 0
BRACE20079370 28.774 29.318 0 18.484 0 0 0 0 0 0 0 0 0
BRACE20097540 0 0 0 100 0 0 0 0 0 0 0 0 0 BRACE20098860 0 0 0 100 0
0 0 0 0 0 0 0 0 BRACE20099070 0 0 0 100 0 0 0 0 0 0 0 0 0
BRACE20194670 0 0 0 100 0 0 0 0 0 0 0 0 0 BRACE20196180 0 0 0 100 0
0 0 0 0 0 0 0 0 BRACE20196960 0 0 0 100 0 0 0 0 0 0 0 0 0
BRACE20200770 0 0 0 100 0 0 0 0 0 0 0 0 0 BRACE20200970 0 0 0 100 0
0 0 0 0 0 0 0 0 BRACE20204670 0 0 0 6.427 0 0 0 0 0 0 0 0 0
BRACE20205840 0 0 0 100 0 0 0 0 0 0 0 0 0 BRACE20207420 0 0 0 100 0
0 0 0 0 0 0 0 0 BRACE20212450 0 0 0 23.804 0 0 0 0 0 0 0 0 0
BRACE20215410 0 0 0 26.992 0 26.03 0 0 0 0 0 0 0 BRACE20216700 0 0
0 100 0 0 0 0 0 0 0 0 0 BRACE20216950 0 0 0 100 0 0 0 0 0 0 0 0 0
BRACE20219360 0 0 0 40.506 0 0 0 0 0 0 0 0 0 BRAMY10000980 0 0 0 0
0 100 0 0 0 0 0 0 0 BRAMY10001730 0 0 0 0 0 100 0 0 0 0 0 0 0
BRAMY20000210 0 0 0 0 0 100 0 0 0 0 0 0 0 BRAMY20000250 0 0 0 0 0
49.943 0 50.057 0 0 0 0 0 BRAMY20001510 0 0 0 0 2.866 1.815 3.116 0
0 0 0 0 0
[1720] TABLE-US-00085 TABLE 18 BRAMY20003540 4.956 0 0 3.184 0 3.07
10.541 6.155 0 9.538 0 4.824 0 BRAMY20003880 0 0 0 0 0 11.085
19.028 0 0 11.478 0 0 0 BRAMY20005080 0 0 0 0 0 19.453 33.393 0 0 0
0 30.564 0 BRAMY20013670 0 0 0 0 0 100 0 0 0 0 0 0 0 BRAMY20016780
0 0 0 0 0 100 0 0 0 0 0 0 0 BRAMY20020440 0 0 0 0 0 100 0 0 0 0 0 0
0 BRAMY20021580 0 0 0 0 0 100 0 0 0 0 0 0 0 BRAMY20023390 0 0 0 0 0
100 0 0 0 0 0 0 0 BRAMY20023640 0 0 0 0 0 100 0 0 0 0 0 0 0
BRAMY20024790 0 0 0 0 0 38.893 0 0 0 0 0 61.107 0 BRAMY20027390 0 0
0 0 0 100 0 0 0 0 0 0 0 BRAMY20027990 0 0 0 0 0 100 0 0 0 0 0 0 0
BRAMY20028530 0 0 0 0 0 100 0 0 0 0 0 0 0 BRAMY20028620 0 0 0 0 0
100 0 0 0 0 0 0 0 BRAMY20035380 0 0 0 0 0 100 0 0 0 0 0 0 0
BRAMY20035830 9.114 0 0 0 0 22.586 0 0 0 0 0 0 0 BRAMY20036530 0 0
0 0 0 13.18 0 0 0 0 0 0 0 BRAMY20036810 0 0 0 0 0 61.711 0 0 0 0 0
0 0 BRAMY20038980 0 0 0 0 0 100 0 0 0 0 0 0 0 BRAMY20039290 61.747
0 0 0 0 38.253 0 0 0 0 0 0 0 BRAMY20040580 0 0 0 0 0 100 0 0 0 0 0
0 0 BRAMY20043520 0 0 0 0 0 100 0 0 0 0 0 0 0 BRAMY20043630 1.86 0
3.629 0 0 2.304 0 0 0 0 0 0 0 BRAMY20044920 0 0 0 0 0 100 0 0 0 0 0
0 0 BRAMY20045210 0 0 0 0 0 29.335 0 0 0 0 0 0 0 BRAMY20045420 0 0
0 0 0 100 0 0 0 0 0 0 0 BRAMY20047560 0 0 0 0 0 24.533 0 0 0 0 0 0
0 BRAMY20050640 0 0 0 0 0 100 0 0 0 0 0 0 0 BRAMY20050940 0 0 0 0 0
100 0 0 0 0 0 0 0 BRAMY20051820 0 0 0 0 0 100 0 0 0 0 0 0 0
BRAMY20052440 0 0 0 0 0 53.973 0 0 0 0 0 0 0 BRAMY20053910 0 0 0 0
0 100 0 0 0 0 0 0 0 BRAMY20055760 0 0 0 0 0 34.804 0 0 0 0 0 0 0
BRAMY20056620 0 0 0 0 0 100 0 0 0 0 0 0 0 BRAMY20056840 0 0 0 0 0
100 0 0 0 0 0 0 0 BRAMY20063750 0 0 0 0 0 53.973 0 0 0 0 0 0 0
BRAMY20072440 0 17.768 0 16.803 0 32.409 0 16.241 0 16.78 0 0 0
[1721] TABLE-US-00086 TABLE 19 BRAMY20072870 0 0 0 0 0 23.589 0 0 0
0 0 0 0 BRAMY20073080 0 0 0 0 0 100 0 0 0 0 0 0 0 BRAMY20074110 0 0
0 0 0 100 0 0 0 0 0 0 0 BRAMY20074860 0 0 0 0 0 100 0 0 0 0 0 0 0
BRAMY20076100 0 0 0 0 0 100 0 0 0 0 0 0 0 BRAMY20076130 10.199
6.928 0 6.552 9.974 18.955 0 0 0 19.628 0 9.927 0 BRAMY20076530 0 0
0 0 0 100 0 0 0 0 0 0 0 BRAMY20083330 0 0 0 0 0 100 0 0 0 0 0 0 0
BRAMY20083820 0 0 0 0 0 100 0 0 0 0 0 0 0 BRAMY20089770 0 0 0 0 0
10.831 0 0 0 11.215 0 0 0 BRAMY20091230 0 0 0 0 37.206 23.57 0 0 0
0 0 0 0 BRAMY20093490 0 0 0 0 0 37.535 0 0 0 0 0 0 0 BRAMY20094890
0 0 0 0 0 100 0 0 0 0 0 0 0 BRAMY20095080 0 0 0 0 0 49.016 0 0 0
25.378 0 0 0 BRAMY20095570 0 0 0 0 0 49.128 0 0 0 50.872 0 0 0
BRAMY20096930 0 0 0 0 0 100 0 0 0 0 0 0 0 BRAMY20100680 0 0 0 0 0
100 0 0 0 0 0 0 0 BRAMY20102900 0 0 0 0 0 100 0 0 0 0 0 0 0
BRAMY20107980 0 0 0 0 0 100 0 0 0 0 0 0 0 BRAMY20111780 0 0 0 0 0
100 0 0 0 0 0 0 0 BRAMY20117670 11.164 0 0 14.344 0 6.916 0 0 0 0
33.738 10.866 0 BRAMY20118410 0 0 0 0 0 49.128 0 0 0 50.872 0 0 0
BRAMY20118490 0 0 0 0 0 49.128 0 0 0 50.872 0 0 0 BRAMY20120170 0 0
0 0 0 100 0 0 0 0 0 0 0 BRAMY20123400 0 0 0 0 0 49.128 0 0 0 50.872
0 0 0 BRAMY20124970 0 0 0 0 0 100 0 0 0 0 0 0 0 BRAMY20125170 0
52.301 0 0 0 47.699 0 0 0 0 0 0 0 BRAMY20125360 0 0 0 0 0 17.442 0
17.481 26.994 0 0 0 0 BRAMY20125550 0 0 0 0 0 100 0 0 0 0 0 0 0
BRAMY20126910 0 0 0 0 0 100 0 0 0 0 0 0 0 BRAMY20127310 0 0 0 0 0
100 0 0 0 0 0 0 0 BRAMY20127760 0 0 0 0 0 100 0 0 0 0 0 0 0
BRAMY20134050 0 0 0 0 0 100 0 0 0 0 0 0 0 BRAMY20135720 0 0 0 0 0
100 0 0 0 0 0 0 0 BRAMY20137360 0 0 0 0 0 100 0 0 0 0 0 0 0
BRAMY20139440 0 0 0 0 0 100 0 0 0 0 0 0 0 BRAMY20139750 0 0 0 0 0
100 0 0 0 0 0 0 0
[1722] TABLE-US-00087 TABLE 20 BRAMY20143870 0 0 0 0 0 100 0 0 0 0
0 0 0 BRAMY20152510 17.703 0 0 0 0 21.934 37.651 0 0 22.713 0 0 0
BRAMY20155500 0 0 0 0 0 53.973 0 0 0 0 0 0 0 BRAMY20158550 0 0 0 0
0 100 0 0 0 0 0 0 0 BRAMY20159250 0 0 0 0 0 100 0 0 0 0 0 0 0
BRAMY20160020 0 0 0 0 0 100 0 0 0 0 0 0 0 BRAMY20173480 0 0 0 0 0
100 0 0 0 0 0 0 0 BRAMY20190550 0 0 0 0 0 5.278 0 5.289 0 5.465
8.581 8.292 0 BRAMY20194680 0 0 0 0 0 100 0 0 0 0 0 0 0
BRAMY20204270 0 2.605 0 0 3.75 4.752 4.078 2.381 0 2.46 0 7.465 0
BRAMY20206340 0 0 0 0 0 100 0 0 0 0 0 0 0 BRAMY20219620 0 0 0 0 0
100 0 0 0 0 0 0 0 BRAMY20221600 0 0 0 0 0 53.973 0 0 0 0 0 0 0
BRAMY20223010 0 0 0 0 0 100 0 0 0 0 0 0 0 BRAMY20225250 0 0 0 0 0
100 0 0 0 0 0 0 0 BRAMY20225320 0 0 0 0 0 100 0 0 0 0 0 0 0
BRAMY20227230 0 0 0 0 0 100 0 0 0 0 0 0 0 BRAMY20227860 1.466 1.494
0.715 1.884 2.151 8.177 6.238 5.919 4.218 9.408 2.216 0 1.978
BRAMY20227960 44.662 0 0 0 0 55.338 0 0 0 0 0 0 0 BRAMY20231150 0 0
0 0 0 49.128 0 0 0 50.872 0 0 0 BRAMY20234820 0 0 0 0 0 100 0 0 0 0
0 0 0 BRAMY20237190 0 0 0 0 0 19.827 0 0 0 0 0 0 0 BRAMY20238630 0
0 0 0 0 100 0 0 0 0 0 0 0 BRAMY20243120 0 0 0 0 0 100 0 0 0 0 0 0 0
BRAMY20244490 0 0 0 0 0 100 0 0 0 0 0 0 0 BRAMY20245140 0 0 0 0 0
100 0 0 0 0 0 0 0 BRAMY20245350 0 0 0 0 0 100 0 0 0 0 0 0 0
BRAMY20245760 0 0 0 0 0 100 0 0 0 0 0 0 0 BRAMY20251210 0 0 0 0 0
49.943 0 50.057 0 0 0 0 0 BRAMY20251750 0 0 0 0 0 100 0 0 0 0 0 0 0
BRAMY20263000 0 0 0 0 0 100 0 0 0 0 0 0 0 BRAMY20267780 1.836 0 0 0
0 2.275 0 0 0 0 0 0 0 BRAMY20269040 0 0 0 0 0 100 0 0 0 0 0 0 0
BRAMY20271140 0 0 0 0 0 100 0 0 0 0 0 0 0 BRAMY20274510 0 0 0 0 0
100 0 0 0 0 0 0 0 BRAMY20285650 0 0 0 0 0 61.711 0 0 0 0 0 0 0
BRAMY20287400 0 0 0 0 0 100 0 0 0 0 0 0 0
[1723] TABLE-US-00088 TABLE 21 BRAWH20014590 0 0 0 0 0 0 43.087 0 0
12.996 20.407 0 0 BRAWH20020470 0 0 0 37.659 0 0 62.341 0 0 0 0 0 0
BRAWH20020600 0 0 0 0 0 0 100 0 0 0 0 0 0 BRAWH20021910 0 0 0 0 0 0
100 0 0 0 0 0 0 BRAWH20025490 0 0 0 0 0 0 52.588 0 47.412 0 0 0 0
BRAWH20026010 0 0 0 0 0 0 27.777 16.218 0 0 0 0 0 BRAWH20027250 0 0
0 0 0 0 24.306 0 0 0 0 0 0 BRAWH20030000 0 0 0 0 0 0 100 0 0 0 0 0
0 BRAWH20039640 0 0 0 0 0 0 100 0 0 0 0 0 0 BRAWH20040680 0 0 0 0 0
0 100 0 0 0 0 0 0 BRAWH20047790 0 0 0 0 0 0 100 0 0 0 0 0 0
BRAWH20050740 31.981 0 0 0 0 0 68.019 0 0 0 0 0 0 BRAWH20055240 0 0
0 0 0 0 100 0 0 0 0 0 0 BRAWH20055330 0 0 0 0 0 0 100 0 0 0 0 0 0
BRAWH20055780 0 0 0 0 0 0 45.321 0 0 54.679 0 0 0 BRAWH20058120 0 0
0 0 0 0 100 0 0 0 0 0 0 BRAWH20063010 0 0 0 0 0 0 100 0 0 0 0 0 0
BRAWH20078080 0 0 0 0 0 0 100 0 0 0 0 0 0 BRAWH20078620 0 0 0 0 0 0
100 0 0 0 0 0 0 BRAWH20080580 0 0 47.847 0 0 0 52.153 0 0 0 0 0 0
BRAWH20082550 4.964 0 9.686 0 0 6.151 10.558 0 0 0 0 0 0
BRAWH20082920 0 0 0 0 0 0 69.313 0 0 0 0 0 0 BRAWH20093040 0 0 0 0
0 0 29.619 0 26.704 0 0 0 0 BRAWH20093070 0 0 0 24.51 0 0 27.05 0 0
8.159 0 0 0 BRAWH20094900 0 0 0 37.659 0 0 62.341 0 0 0 0 0 0
BRAWH20095900 0 0 0 0 0 36.811 63.189 0 0 0 0 0 0 BRAWH20173790 0 0
0 0 0 23.285 39.971 0 0 0 0 0 0 BRAWH20174330 0 0 0 0 0 0 100 0 0 0
0 0 0 BRAWH20175230 0 0 0 0 0 0 100 0 0 0 0 0 0 BRAWH20175340 0 0 0
0 0 0 100 0 0 0 0 0 0 BRAWH20176850 0 0 29.749 0 0 18.89 32.427
18.933 0 0 0 0 0 BRAWH20182670 0 0 0 0 0 0 100 0 0 0 0 0 0
BRAWH20183170 0 0 0 0 0 0 100 0 0 0 0 0 0 BRAWH20185260 0 0 0 0 0
36.811 63.189 0 0 0 0 0 0 BRAWH20185270 0 0 0 0 0 0 35.8 0 0 0 0 0
0 BRAWH20186010 0 0 0 0 0 0 100 0 0 0 0 0 0 BRAWH20188750 0 0 0 0 0
0 100 0 0 0 0 0 0
[1724] TABLE-US-00089 TABLE 22 BRAWH20190530 0 0 0 0 0 0 100 0 0 0
0 0 0 BRAWH20190550 0 0 0 0 0 0 100 0 0 0 0 0 0 BRAWH20191980 0 0 0
37.659 0 0 62.341 0 0 0 0 0 0 BRCAN10000760 0 0 0 0 0 0 0 6.922 0 0
0 0 0 BRCAN10001050 0 0 0 0 0 0 0 100 0 0 0 0 0 BRCAN10001680 0
5.009 0 0 0 9.137 0 13.737 0 14.193 0 14.356 0 BRCAN20001480 0 0 0
0 0 0 0 100 0 0 0 0 0 BRCAN20004180 0 0 0 0 0 0 0 100 0 0 0 0 0
BRCAN20005230 0 0 0 0 0 0 0 100 0 0 0 0 0 BRCAN20005410 0 0 0 0 0 0
0 100 0 0 0 0 0 BRCOC10000400 0 0 0 0 0 0 0 0 59.913 40.087 0 0 0
BRCOC20000470 0 0 0 0 50.495 0 0 0 49.505 0 0 0 0 BRCOC20003600 0 0
0 0 0 0 39.923 0 35.994 24.083 0 0 0 BRHIF10000720 0 0 0 0 0 0 0 0
0 100 0 0 0 BRHIP10001040 1.184 1.608 0 0 6.947 7.335 12.591 13.233
13.622 10.633 7.156 4.61 0 BRHIP20000210 0 0 0 0 0 0 0 0 0 100 0 0
0 BRHIP20003590 0 0 0 0 0 0 0 0 0 100 0 0 0 BRHIP20005060 0 0 0 0 0
0 0 0 0 38.356 0 0 0 BRSSN20001970 0 0 0 0 0 0 0 0 0 0 100 0 0
BRSSN20005610 23.474 15.945 0 0 0 14.542 0 0 0 0 23.646 0 0
BRSSN20005660 0 34.081 0 16.116 24.533 0 0 0 0 0 25.27 0 0
BRSSN20066440 0 0 0 0 0 0 0 0 0 0 100 0 0 BRSSN20074640 0 0 0 0 0 0
0 0 48.765 0 51.235 0 0 BRSSN20091190 0 0 0 0 0 0 0 0 0 0 68.148 0
0 BRSSN20092440 0 0 0 0 0 0 0 0 0 0 34.564 0 0 BRSSN20093890 0 0 0
0 0 0 0 0 0 0 100 0 0 CTONG20032930 0 32.048 0 0 0 0 0 0 0 0 0 0 0
CTONG20035240 44.214 0 0 0 0 0 0 0 0 0 0 0 0 CTONG20044870 0 0 0 0
0 0 0 0 0 25.315 0 0 0 CTONG20063930 0 0 0 0 0 27.859 0 0 0 0 0
43.771 0 CTONG20069320 0 0 0 5.712 0 5.509 0 0 0 0 0 0 0
CTONG20070720 0 0 0 0 11.919 0 0 7.568 0 0 12.278 0 0 CTONG20071040
0 0 0 0 0 0 0 15.932 0 0 51.694 0 0 CTONG20071680 0 0 0 0 0 0 0 0 0
50.418 0 0 0 CTONG20074170 44.214 0 0 0 0 0 0 0 0 0 0 0 0
CTONG20078340 0 0 0 0 0 0 0 0 0 25.315 0 0 0 CTONG20079590 0 0 0 0
14.657 0 0 0 0 0 15.097 0 0
[1725] TABLE-US-00090 TABLE 23 CTONG20080140 0 0 0 0 0 0 0 0 0
28.14 44.187 0 0 CTONG20085210 44.007 0 0 0 0 0 0 0 0 28.231 0 0 0
CTONG20133720 0 0 0 0 0 5.755 0 0 0 5.959 0 0 0 CTONG20165750
23.734 0 18.524 0 0 0 0 0 0 0 0 0 0 CTONG20168240 18.734 0 0 0 0 0
0 0 0 0 0 0 0 CTONG20170940 0 0 0 0 0 0 10.747 0 0 0 0 0 0
CTONG20183430 44.214 0 0 0 0 0 0 0 0 0 0 0 0 CTONG20186370 31.217 0
0 0 0 0 0 0 0 0 0 0 0 CTONG20188080 0 0 0 0 0 6.701 0 0 10.371
13.878 0 0 0 FCBBF10000230 100 0 0 0 0 0 0 0 0 0 0 0 0
FCBBF10002200 100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF10004760 100 0 0 0 0
0 0 0 0 0 0 0 0 FCBBF20018680 100 0 0 0 0 0 0 0 0 0 0 0 0
FCBBF20020440 100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF20021110 100 0 0 0 0
0 0 0 0 0 0 0 0 FCBBF20023490 3.866 10.504 0 0 0 0 0 0 7.413 4.96 0
7.525 0 FCBBF20028980 100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF20029280
43.802 0 0 0 0 0 0 0 0 56.198 0 0 0 FCBBF20032930 33.937 0 0 0 0 0
0 0 0 0 0 66.063 0 FCBBF20033360 23.246 0 22.679 0 0 4.8 0 0 7.429
4.971 0 0 0 FCBBF20035430 100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF20035490
19.559 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF20036360 100 0 0 0 0 0 0 0 0 0
0 0 0 FCBBF20038230 100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF20038950 100 0
0 0 0 0 0 0 0 0 0 0 0 FCBBF20041380 100 0 0 0 0 0 0 0 0 0 0 0 0
FCBBF20043730 100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF20054390 100 0 0 0 0
0 0 0 0 0 0 0 0 FCBBF20056580 33.254 0 0 0 0 0 0 0 0 0 0 0 0
FCBBF20059660 33.765 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF20061310 100 0 0
0 0 0 0 0 0 0 0 0 0 FCBBF20066340 10.481 0 0 0 0 0 0 13.016 0 0 0 0
0 FCBBF20070800 9.281 12.609 0 0 0 11.5 19.741 23.052 0 23.817 0 0
0 FCBBF20070950 11.871 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30000010 100 0
0 0 0 0 0 0 0 0 0 0 0 FCBBF30001020 100 0 0 0 0 0 0 0 0 0 0 0 0
FCBBF30001100 19.4 0 37.855 0 0 0 0 0 0 0 0 0 0
[1726] TABLE-US-00091 TABLE 24 FCBBF30001150 100 0 0 0 0 0 0 0 0 0
0 0 0 FCBBF30002270 20.773 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30002280
100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30002330 100 0 0 0 0 0 0 0 0 0 0 0
0 FCBBF30003610 100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30004340 8.95 0
8.731 17.248 8.752 5.544 0 11.114 0 11.482 9.015 0 0 FCBBF30004730
100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30005180 100 0 0 0 0 0 0 0 0 0 0 0
0 FCBBF30005360 20.082 0 0 0 0 0 0 0 38.509 0 0 0 0 FCBBF30005500
100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30019140 100 0 0 0 0 0 0 0 0 0 0 0
0 FCBBF30019180 100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30019240 100 0 0 0
0 0 0 0 0 0 0 0 0 FCBBF30021900 100 0 0 0 0 0 0 0 0 0 0 0 0
FCBBF30022680 100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30026580 42.399
57.601 0 0 0 0 0 0 0 0 0 0 0 FCBBF30029250 28.042 0 0 0 0 0 0 0 0
71.958 0 0 0 FCBBF30035570 100 0 0 0 0 0 0 0 0 0 0 0 0
FCBBF30042610 100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30048420 100 0 0 0 0
0 0 0 0 0 0 0 0 FCBBF30053300 3.746 2.544 0 0 0 0 0 2.326 0 0 0 0 0
FCBBF30056980 34.251 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30062490 100 0 0
0 0 0 0 0 0 0 0 0 0 FCBBF30063990 100 0 0 0 0 0 0 0 0 0 0 0 0
FCBBF30068210 100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30071500 100 0 0 0 0
0 0 0 0 0 0 0 0 FCBBF30072440 36.866 0 0 0 0 0 0 0 0 0 0 0 0
FCBBF30072480 100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30074530 100 0 0 0 0
0 0 0 0 0 0 0 0 FCBBF30074620 100 0 0 0 0 0 0 0 0 0 0 0 0
FCBBF30075970 100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30076310 100 0 0 0 0
0 0 0 0 0 0 0 0 FCBBF30078600 100 0 0 0 0 0 0 0 0 0 0 0 0
FCBBF30079770 42.399 57.601 0 0 0 0 0 0 0 0 0 0 0 FCBBF30080730
34.275 0 0 0 0 0 0 0 65.725 0 0 0 0 FCBBF30081000 20.379 0 39.764 0
39.858 0 0 0 0 0 0 0 0 FCBBF30085560 100 0 0 0 0 0 0 0 0 0 0 0
0
[1727] TABLE-US-00092 TABLE 25 FCBBF30088700 100 0 0 0 0 0 0 0 0 0
0 0 0 FCBBF30089380 51.503 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30091010
100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30091520 100 0 0 0 0 0 0 0 0 0 0 0
0 FCBBF30093170 72.234 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30095410 20.765
0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30099490 100 0 0 0 0 0 0 0 0 0 0 0 0
FCBBF30100080 100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30100120 30.645
11.895 25.627 0 8.563 0 9.311 5.437 0 0 0 8.522 0 FCBBF30100410
56.537 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30101240 100 0 0 0 0 0 0 0 0 0
0 0 0 FCBBF30101300 100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30105080 100 0
0 0 0 0 0 0 0 0 0 0 0 FCBBF30105440 100 0 0 0 0 0 0 0 0 0 0 0 0
FCBBF30105860 100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30106950 30.112 0 0
0 0 0 0 0 0 0 0 0 0 FCBBF30107290 56.537 0 0 0 0 0 0 0 0 0 0 0 0
FCBBF30107330 100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30114180 100 0 0 0 0
0 0 0 0 0 0 0 0 FCBBF30114850 100 0 0 0 0 0 0 0 0 0 0 0 0
FCBBF30115230 30.112 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30115920 100 0 0
0 0 0 0 0 0 0 0 0 0 FCBBF30118670 100 0 0 0 0 0 0 0 0 0 0 0 0
FCBBF30118890 100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30125460 4.752 6.455
9.271 0 0 17.662 0 5.901 0 12.193 0 0 0 FCBBF30125880 100 0 0 0 0 0
0 0 0 0 0 0 0 FCBBF30128420 100 0 0 0 0 0 0 0 0 0 0 0 0
FCBBF30129010 100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30130410 100 0 0 0 0
0 0 0 0 0 0 0 0 FCBBF30130580 100 0 0 0 0 0 0 0 0 0 0 0 0
FCBBF30132050 100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30132660 100 0 0 0 0
0 0 0 0 0 0 0 0 FCBBF30135890 34.566 0 0 0 0 0 0 0 0 0 0 0 0
FCBBF30136230 100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30138000 100 0 0 0 0
0 0 0 0 0 0 0 0 FCBBF30142290 100 0 0 0 0 0 0 0 0 0 0 0 0
FCBBF30143550 100 0 0 0 0 0 0 0 0 0 0 0 0
[1728] TABLE-US-00093 TABLE 26 FCBBF30145670 100 0 0 0 0 0 0 0 0 0
0 0 0 FCBBF30151190 100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30153170 100 0
0 0 0 0 0 0 0 0 0 0 0 FCBBF30157270 56.537 0 0 0 0 0 0 0 0 0 0 0 0
FCBBF30161780 100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30164510 100 0 0 0 0
0 0 0 0 0 0 0 0 FCBBF30166220 100 0 0 0 0 0 0 0 0 0 0 0 0
FCBBF30169280 16.742 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30169870 43.802 0
0 0 0 0 0 0 0 56.198 0 0 0 FCBBF30170710 100 0 0 0 0 0 0 0 0 0 0 0
0 FCBBF30171230 100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30172330 100 0 0 0
0 0 0 0 0 0 0 0 0 FCBBF30173960 56.537 0 0 0 0 0 0 0 0 0 0 0 0
FCBBF30175350 8.107 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30177290 100 0 0 0
0 0 0 0 0 0 0 0 0 FCBBF30179180 43.582 0 0 0 0 0 0 0 0 0 0 0 0
FCBBF30179740 100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30181730 100 0 0 0 0
0 0 0 0 0 0 0 0 FCBBF30194370 100 0 0 0 0 0 0 0 0 0 0 0 0
FCBBF30194550 100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30195690 100 0 0 0 0
0 0 0 0 0 0 0 0 FCBBF30195700 100 0 0 0 0 0 0 0 0 0 0 0 0
FCBBF30197840 100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30198670 100 0 0 0 0
0 0 0 0 0 0 0 0 FCBBF30201630 100 0 0 0 0 0 0 0 0 0 0 0 0
FCBBF30212210 100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30215240 100 0 0 0 0
0 0 0 0 0 0 0 0 FCBBF30220050 100 0 0 0 0 0 0 0 0 0 0 0 0
FCBBF30222910 100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30223110 100 0 0 0 0
0 0 0 0 0 0 0 0 FCBBF30223210 100 0 0 0 0 0 0 0 0 0 0 0 0
FCBBF30225930 21.93 0 0 0 0 27.172 0 0 0 0 0 0 0 FCBBF30228940
51.503 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30230610 100 0 0 0 0 0 0 0 0 0
0 0 0 FCBBF30236670 0.694 2.83 0 0.892 1.358 0 0 2.586 0 0.891
2.797 0 3.745 FCBBF30250980 100 0 0 0 0 0 0 0 0 0 0 0 0
FCBBF30255680 100 0 0 0 0 0 0 0 0 0 0 0 0
[1729] TABLE-US-00094 TABLE 27 FCBBF30257370 15.348 13.901 0 0 0 0
0 0 0 0 0 9.959 0 FCBBF30259050 43.768 0 0 56.232 0 0 0 0 0 0 0 0 0
FCBBF30260210 100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30260480 100 0 0 0 0
0 0 0 0 0 0 0 0 FCBBF30263080 23.584 0 0 0 0 0 0 29.288 0 0 0 0 0
FCBBF30266510 56.537 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30271990 100 0 0
0 0 0 0 0 0 0 0 0 0 FCBBF30275590 100 0 0 0 0 0 0 0 0 0 0 0 0
FCBBF30282020 46.286 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF30285930 100 0 0
0 0 0 0 0 0 0 0 0 0 FCBBF30287940 100 0 0 0 0 0 0 0 0 0 0 0 0
FCBBF40000610 100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF40001920 100 0 0 0 0
0 0 0 0 0 0 0 0 FCBBF40005000 16.459 0 0 0 0 0 0 0 0 0 0 0 0
FCBBF50000410 100 0 0 0 0 0 0 0 0 0 0 0 0 FCBBF50000610 43.582 0 0
0 0 0 0 0 0 0 0 0 0 FCBBF50001650 33.921 15.361 0 14.527 0 14.01 0
0 0 0 0 0 0 FCBBF50003530 44.606 0 0 0 0 0 0 55.394 0 0 0 0 0
FCBBF50004950 100 0 0 0 0 0 0 0 0 0 0 0 0 FEBRA20005040 0 100 0 0 0
0 0 0 0 0 0 0 0 FEBRA20007820 0 100 0 0 0 0 0 0 0 0 0 0 0
FEBRA20018670 27.69 18.809 0 0 0 0 0 0 26.549 0 0 26.952 0
FEBRA20026820 0 100 0 0 0 0 0 0 0 0 0 0 0 FEBRA20027070 0 8.946 0 0
0 0 0 0 0 0 0 0 0 FEBRA20029620 0 100 0 0 0 0 0 0 0 0 0 0 0
FEBRA20031000 23.203 31.522 45.275 0 0 0 0 0 0 0 0 0 0
FEBRA20031150 0 100 0 0 0 0 0 0 0 0 0 0 0 FEBRA20031280 0 58.203
41.797 0 0 0 0 0 0 0 0 0 0 FEBRA20031810 0 100 0 0 0 0 0 0 0 0 0 0
0 FEBRA20035200 0 100 0 0 0 0 0 0 0 0 0 0 0 FEBRA20035240 0 100 0 0
0 0 0 0 0 0 0 0 0 FEBRA20038220 0 22.453 0 0 0 0 0 0 0 0 0 0 0
FEBRA20038330 5.634 15.308 5.497 0 0 6.981 0 0 5.402 0 0 0 15.195
FEBRA20038970 0 100 0 0 0 0 0 0 0 0 0 0 0 FEBRA20039070 0 100 0 0 0
0 0 0 0 0 0 0 0 FEBRA20039260 0 2.55 0 2.411 0 2.325 0 0 3.599
2.408 0 3.654 0 FEBRA20040230 0 63.862 0 0 0 0 0 0 0 0 0 0 0
[1730] TABLE-US-00095 TABLE 28 FEBRA20040260 0 56.854 0 0 0 0 0 0 0
0 0 0 0 FEBRA20040290 2.043 2.776 0 0 7.992 2.531 0 5.074 0 0 0 0
11.021 FEBRA20040560 0 59.062 0 0 0 0 0 0 0 0 0 0 0 FEBRA20045380 0
100 0 0 0 0 0 0 0 0 0 0 0 FEBRA20046200 0 17.561 0 0 0 0 0 0 0 0 0
0 0 FEBRA20046280 0 100 0 0 0 0 0 0 0 0 0 0 0 FEBRA20046510 0 100 0
0 0 0 0 0 0 0 0 0 0 FEBRA20057010 0 100 0 0 0 0 0 0 0 0 0 0 0
FEBRA20063720 0 34.914 12.537 0 0 0 0 0 0 0 0 0 0 FEBRA20076200 0
100 0 0 0 0 0 0 0 0 0 0 0 FEBRA20078180 0 20.719 0 0 0 0 0 0 0 0 0
0 0 FEBRA20078800 0 22.544 0 0 0 0 0 0 0 0 0 0 0 FEBRA20080860 0
100 0 0 0 0 0 0 0 0 0 0 0 FEBRA20082660 0 22.641 0 0 0 0 0 0 0 0 0
0 0 FEBRA20083410 0 14.361 0 0 0 0 0 0 0 0 0 0 0 FEBRA20084750 0
100 0 0 0 0 0 0 0 0 0 0 0 FEBRA20086600 0 100 0 0 0 0 0 0 0 0 0 0 0
FEBRA20087550 0 6.921 0 0 0 0 0 0 9.769 0 0 0 0 FEBRA20088610
24.122 32.771 15.689 0 0 0 17.101 0 0 10.316 0 0 0 FEBRA20088810 0
100 0 0 0 0 0 0 0 0 0 0 0 FEBRA20090160 0 100 0 0 0 0 0 0 0 0 0 0 0
FEBRA20090220 0 6.554 2.353 0 2.359 0 2.565 0 6.938 0 2.43 0 0
FEBRA20091620 0 100 0 0 0 0 0 0 0 0 0 0 0 FEBRA20092760 0 100 0 0 0
0 0 0 0 0 0 0 0 FEBRA20093270 0 100 0 0 0 0 0 0 0 0 0 0 0
FEBRA20093280 0 100 0 0 0 0 0 0 0 0 0 0 0 FEBRA20095410 0 59.062 0
0 0 0 0 0 0 0 0 0 0 FEBRA20098040 13.01 35.349 0 0 0 0 0 0 24.947
16.692 0 0 0 FEBRA20099860 0 34.616 0 0 0 0 0 0 0 65.384 0 0 0
FEBRA20101410 0 100 0 0 0 0 0 0 0 0 0 0 0 FEBRA20108020 0 100 0 0 0
0 0 0 0 0 0 0 0 FEBRA20108580 8.812 35.914 0 0 0 0 0 0 0 0 0 0 0
FEBRA20115930 0 100 0 0 0 0 0 0 0 0 0 0 0 FEBRA20116650 18.022
24.484 35.165 0 0 22.329 0 0 0 0 0 0 0 FEBRA20121200 0 36.922 0 0 0
0 0 0 0 0 0 0 0 FEBRA20121950 0 100 0 0 0 0 0 0 0 0 0 0 0
FEBRA20141980 0 100 0 0 0 0 0 0 0 0 0 0 0
[1731] TABLE-US-00096 TABLE 29 FEBRA20150420 0 34.905 0 0 0 31.834
0 0 0 0 0 0 0 FEBRA20151750 0 100 0 0 0 0 0 0 0 0 0 0 0
FEBRA20163980 9.44 12.825 0 0 0 0 0 0 0 0 0 0 0 FEBRA20170240 0
36.922 0 0 0 0 0 0 0 0 0 0 0 FEBRA20172230 0 100 0 0 0 0 0 0 0 0 0
0 0 FEBRA20173330 0 100 0 0 0 0 0 0 0 0 0 0 0 FEBRA20175020 0 100 0
0 0 0 0 0 0 0 0 0 0 FEBRA20175330 0 100 0 0 0 0 0 0 0 0 0 0 0
FEBRA20177800 0 100 0 0 0 0 0 0 0 0 0 0 0 FEBRA20180510 0 100 0 0 0
0 0 0 0 0 0 0 0 FEBRA20182030 42.399 57.601 0 0 0 0 0 0 0 0 0 0 0
FEBRA20187460 0 100 0 0 0 0 0 0 0 0 0 0 0 FEBRA20191720 0 100 0 0 0
0 0 0 0 0 0 0 0 HCHON20002650 0 0 0 19.66 0 0 0 0 0 0 0 0 0
HCHON20002710 13.027 17.697 0 0 0 0 0 0 0 0 0 0 0 HEART10001490
3.58 0 6.986 0 0 0 0 0 0 0 0 0 0 HLUNG20008460 0 0 32.46 0 0 0 0 0
0 0 0 0 0 HLUNG20011460 0 0 0 0 0 0 0 23.423 0 0 0 0 0
HLUNG20014590 0 0 0 0 0 0 0 11.025 0 0 0 0 0 HLUNG20015070 0 0 0 0
0 5.433 0 0 8.409 0 0 0 0 HLUNG20015180 0 3.161 0 0 0 0 0 0 0 0
4.688 0 0 HLUNG20020850 0 0 0 0 32.512 0 0 0 0 0 0 0 0
HLUNG20028110 0 0 0 0 0 23.382 0 0 0 0 0 0 0 HLUNG20031620 19.763 0
0 0 0 0 0 0 0 0 0 0 0 HLUNG20032460 0 0 0 0 21.215 0 0 13.47 0 0 0
0 0 HLUNG20033060 0 0 17.556 0 0 0 0 0 0 11.544 0 0 0 HLUNG20041590
2.514 3.415 0 0 0 3.115 0 3.122 0 0 0 0 0 HLUNG20045340 0 0 0 0 0 0
0 0 0 2.424 0 0 0 HLUNG20056560 0 0 0 24.039 0 0 0 0 0 0 0 0 0
HLUNG20068120 6.274 0 0 0 0 0 0 0 0 0 0 0 0 HLUNG20081390 0 0 0 0 0
0 0 0 0 20.993 0 0 0 HLUNG20083480 3.232 0 12.614 4.153 0 4.005 0 0
6.198 4.147 0 0 0 HLUNG20085210 0 0 0 0 0 0 0 0 0 0 0 24.45 0
HLUNG20094130 0 0 0 0 0 0 0 0 0 24.013 0 0 0 KIDNE20080690 0 0 0
7.981 24.298 11.545 0 3.857 17.867 3.985 12.514 12.092 0
KIDNE20084030 0 0 0 0 0 26.283 0 0 0 13.608 0 0 0 KIDNE20086660 0 0
0 0 0 0 52.987 0 0 0 0 0 0
[1732] TABLE-US-00097 TABLE 30 KIDNE20094670 0 0 0 40.506 0 0 0 0 0
0 0 0 0 KIDNE20134130 34.637 0 0 0 0 0 0 0 0 0 0 0 0 KIDNE20138450
20.652 0 0 0 0 0 0 0 0 0 0 0 0 KIDNE20140870 12.151 0 0 0 0 0 0 0
23.3 0 0 0 0 KIDNE20149780 0 0 0 0 0 39.635 0 0 0 0 0 0 0
KIDNE20170400 0 0 0 0 0 0 0 0 0 13.296 0 0 0 KIDNE20173430 0 0 0 0
0 0 0 0 0 0 0 0 26.207 MESAN20021860 0 5.216 0 0 0 0 0 0 0 0 0
7.474 0 MESAN20030350 19.943 0 0 0 0 0 0 0 0 0 0 0 0 MESAN20034440
0 0 0 0 0 0 0 0 0 0 0 19.81 0 MESAN20038520 4.894 0 0 0 0 12.127 0
0 0 0 0 0 0 MESAN20045750 0 0 0 0 0 0 0 0 48.859 0 0 0 0
MESAN20067430 0 0 0 0 0 0 0 0 0 0 0 0 26.308 MESAN20089260 24.608 0
0 0 0 0 0 0 0 0 0 0 0 MESAN20095800 0 0 0 0 0 0 0 8.529 0 8.812
13.837 0 0 NT2NE20026200 0 0 0 0 1.22 11.547 1.328 0.775 1.197 0 0
3.646 0 NT2NE20033150 0 0 49.867 0 0 0 0 0 0 0 0 0 0 NT2NE20042550
0 40.917 0 0 0 0 0 0 0 0 0 0 0 NT2NE20045190 7.802 0 7.612 0 0
4.834 0 0 0 0 7.86 0 21.043 NT2NE20053950 21.964 0 21.429 14.11 0 0
0 0 0 0 0 0 0 NT2NE20061030 20.536 0 0 0 0 0 0 0 0 0 0 0 0
NT2NE20069580 0 40.917 0 0 0 0 0 0 0 0 0 0 0 NT2NE20082130 0 0 0 0
0 0 0 24.112 0 0 0 37.798 0 NT2NE20082600 33.765 0 0 0 0 0 0 0 0 0
0 0 0 NT2NE20088030 0 0 0 39.575 0 0 0 0 0 0 0 0 0 NT2NE20092950 0
14.453 0 0 0 0 0 0 0 13.65 0 20.71 0 NT2NE20095230 0 0 0 0 0 17.429
0 0 0 0 0 27.383 0 NT2NE20108420 23.147 31.446 0 0 0 0 0 0 0 0 0 0
0 NT2NE20111190 0 0 0 0 0 38.711 0 0 0 0 0 0 0 NT2NE20112210 0 0 0
0 0 0 0 0 0 0 0 0 73.331 NT2NE20141040 0 24.941 0 0 0 0 39.046 0 0
0 0 0 0 NT2NE20177210 0 0 0 28.643 0 27.623 0 0 0 0 0 0 0
NT2NE20181800 23.559 0 0 0 0 0 0 0 0 30.226 0 0 0 NT2RI20021200 0 0
0 0 0 4.233 7.265 8.484 6.55 35.063 6.882 6.65 0 NT2RP70001120 0 0
33.312 0 0 0 0 0 0 0 0 0 0 NT2RP70001730 22.691 8.808 31.625 0 0 0
0 0 3.108 0 3.265 0 0 NT2RP70012830 0 0 11.535 0 0 0 0 0 5.668 0 0
11.508 0
[1733] TABLE-US-00098 TABLE 31 NT2RP70035110 12.287 0 0 0 0 0 0 0 0
0 0 0 0 NT2RP70057500 7.128 0 13.909 0 0 0 0 0 0 0 0 0 0
NT2RP70075300 3.525 0 3.439 2.264 0 2.184 0 0 0 0 0 0 0
NT2RP70087140 3.902 10.602 0 10.026 0 24.172 0 0 0 0 0 0 21.047
NT2RP70090870 17.949 0 17.511 0 0 0 0 0 0 0 0 0 0 NTONG20002230 0 0
24.855 0 0 0 0 0 0 0 0 0 0 NTONG20017620 22.333 0 14.526 0 0 18.447
0 0 0 0 14.998 0 0 NTONG20049180 15.998 0 0 0 0 0 0 0 0 0 0 0 0
NTONG20055200 0 0 0 0 0 0 0 3.357 10.367 10.405 0 0 14.581
OCBBF20000740 30.257 10.276 44.279 0 0 9.372 0 0 0 0 0 0 0
OCBBF20001780 0 0 23.138 15.235 23.193 0 0 0 0 0 0 23.084 0
OCBBF20005220 0 0 67.45 0 0 0 0 0 0 0 0 0 0 OCBBF20009820 0 0
10.495 0 0 0 0 0 5.157 0 0 0 0 OCBBF20011860 0 0 100 0 0 0 0 0 0 0
0 0 0 OCBBF20012520 0 0 100 0 0 0 0 0 0 0 0 0 0 OCBBF20016390
10.001 13.586 19.514 0 0 0 21.27 12.419 0 0 0 0 0 OCBBF20016810 0 0
100 0 0 0 0 0 0 0 0 0 0 OCBBF20109450 0 0 100 0 0 0 0 0 0 0 0 0 0
OCBBF20109780 0 0 100 0 0 0 0 0 0 0 0 0 0 OCBBF20110210 23.865 0
46.566 0 0 29.569 0 0 0 0 0 0 0 OCBBF20110730 0 35.856 34.333 0 0 0
18.711 0 0 0 0 0 0 OCBBF20111370 0 0 100 0 0 0 0 0 0 0 0 0 0
OCBBF20111600 0 0 100 0 0 0 0 0 0 0 0 0 0 OCBBF20112280 0 0 100 0 0
0 0 0 0 0 0 0 0 OCBBF20112320 0 0 100 0 0 0 0 0 0 0 0 0 0
OCBBF20113110 0 0 100 0 0 0 0 0 0 0 0 0 0 OCBBF20115360 7.945
10.793 31.004 10.207 0 9.843 0 9.866 0 0 0 0 0 OCBBF20116250 0
41.046 58.954 0 0 0 0 0 0 0 0 0 0 OCBBF20117220 15.972 21.698 62.33
0 0 0 0 0 0 0 0 0 0 OCBBF20118720 0 0 100 0 0 0 0 0 0 0 0 0 0
OCBBF20119810 0 0 100 0 0 0 0 0 0 0 0 0 0 OCBBF20120010 0 0 100 0 0
0 0 0 0 0 0 0 0 OCBBF20120950 0 0 100 0 0 0 0 0 0 0 0 0 0
OCBBF20121910 0 0 100 0 0 0 0 0 0 0 0 0 0 OCBBF20123200 0 0 100 0 0
0 0 0 0 0 0 0 0 OCBBF20142290 0 5.048 21.749 0 0 4.603 0 0 0 14.301
0 0 20.041 OCBBF20147070 0 0 100 0 0 0 0 0 0 0 0 0 0
[1734] TABLE-US-00099 TABLE 32 OCBBF20152330 0 0 100 0 0 0 0 0 0 0
0 0 0 OCBBF20155030 0 0 50.561 0 0 0 0 0 0 0 0 0 0 OCBBF20156450 0
0 100 0 0 0 0 0 0 0 0 0 0 OCBBF20157970 0 0 71.737 0 0 0 0 0 0 0 0
0 0 OCBBF20160380 0 0 100 0 0 0 0 0 0 0 0 0 0 OCBBF20165900 0 0 100
0 0 0 0 0 0 0 0 0 0 OCBBF20165910 0 0 100 0 0 0 0 0 0 0 0 0 0
OCBBF20166890 0 0 33.861 0 0 0 0 0 0 0 0 0 0 OCBBF20166900 0 0 100
0 0 0 0 0 0 0 0 0 0 OCBBF20167290 0 0 19.457 0 0 37.065 0 0 0 0 0 0
0 OCBBF20170350 7.839 10.65 30.593 0 15.332 0 0 9.735 0 10.058
15.793 0 0 OCBBF20174580 25.726 0 25.099 0 0 0 0 0 0 0 0 0 0
OCBBF20174890 0 0 33.338 0 0 0 0 0 0 0 34.421 0 0 OCBBF20175360
10.644 0 20.77 0 0 0 0 0 0 0 0 0 0 OCBBF20176650 0 0 100 0 0 0 0 0
0 0 0 0 0 OCBBF20177540 13.37 18.164 26.088 0 0 0 0 0 0 0 0 0 0
OCBBF20177910 18.157 0 35.429 0 0 0 0 0 0 0 0 0 0 OCBBF20182060 0 0
100 0 0 0 0 0 0 0 0 0 0 OCBBF20185630 0 0 71.737 0 0 0 0 0 0 0 0 0
0 OCBBF20188280 0 0 100 0 0 0 0 0 0 0 0 0 0 OCBBF20191950 0 0 100 0
0 0 0 0 0 0 0 0 0 PLACE60054820 0 0 0 0 0 0 0 19.271 0 0 31.264 0 0
PLACE60056910 0 0 0 0 0 39.559 0 0 0 0 0 0 0 PLACE60061370 0 0 0 0
18.524 11.735 0 11.761 0 0 0 0 0 PLACE60064740 0 0 0 0 0 39.559 0 0
0 0 0 0 0 PLACE60073090 0 0 0 7.15 0 0 0 0 0 0 0 0 0 PLACE60120280
0 0 0 0 0 15.655 0 0 0 0 0 0 0 PLACE60132200 0 0 0 0 0 0 0 0 22.765
0 0 0 0 PLACE60150510 33.854 0 0 0 0 0 0 0 0 0 34.102 0 0
PLACE60154450 0 0 0 0 33.747 0 0 0 0 0 0 33.589 0 PLACE60157310 0 0
0 0 0 0 0 0 66.952 0 0 0 0 PLACE60162100 0 26.059 0 0 0 0 0 0 0 0 0
0 0 PROST10002150 10.939 0 0 14.054 0 0 0 0 0 0 0 0 0 PROST20014150
0 0 67.029 0 0 0 0 0 0 0 0 0 0 PROST20016760 2.116 2.874 0 5.436 0
5.243 4.5 0 0 2.714 0 4.118 0 PROST20024250 0 0 32.244 0 0 20.475 0
0 0 0 0 0 0 PROST20035170 0 0 11.544 0 0 0 0 0 0 0 0 0 0
[1735] TABLE-US-00100 TABLE 33 PROST20035830 34.251 0 0 0 0 0 0 0 0
0 0 0 0 PROST20042700 13.112 0 0 0 0 0 0 16.283 0 0 0 0 0
PROST20045700 11.365 0 0 0 22.229 0 0 0 0 0 0 0 0 PROST20050390
23.916 0 0 0 0 0 0 0 0 0 0 0 0 PROST20054660 0 0 0 40.095 0 0 0 0 0
0 0 0 0 PROST20078710 0 0 33.455 0 0 0 0 0 0 0 0 0 0 PROST20094000
0 0 27.644 0 0 0 0 0 0 0 0 0 0 PROST20097310 0 0 0 0 0 0 0 39.281 0
0 0 0 0 PROST20097840 0 16.947 0 0 0 0 0 0 23.921 16.005 0 0 0
PROST20103820 0 0 0 0 0 39.227 0 0 0 0 0 0 0 PROST20114100 0 0 0 0
0 39.227 0 0 0 0 0 0 0 PROST20130320 0 12.898 0 12.198 0 0 0 0 0
12.181 0 0 0 PROST20151370 0 0 0 0 0 39.227 0 0 0 0 0 0 0
PUAEN10000650 0 0 0 4.545 3.46 0 3.762 8.786 3.392 0 3.564 0 0
PUAEN10001640 0 3.714 0 0 0 0 0 0 0 3.508 0 0 0 PUAEN20003120
15.692 0 0 0 0 0 0 0 0 0 0 0 0 SKNMC20006350 0 0 0 0 0 0 0 0.653 0
0 0 0 2.835 SKNSH10001010 0 0 8.649 5.695 8.669 5.492 9.427 5.504 0
11.373 8.93 0 0 SKNSH20007160 15.069 10.236 0 0 0 0 0 9.356 0 9.667
15.179 0 0 SKNSH20030640 0 0 0 0 26.755 0 0 16.987 0 0 0 0 0
SKNSH20094350 19.559 0 0 0 0 0 0 0 0 0 0 0 0 SMINT20000070 0 18.929
0 0 0 0 0 0 0 0 0 0 0 SMINT20002320 0 0 39.676 0 0 0 0 0 0 0 0 0 0
SMINT20030740 2.994 0 0 0 0 0 0 0 0 0 0 0 0 SMINT20039050 0 0 0 0 0
0 0 5.94 0 0 0 0 25.802 SMINT20045890 0 0 0 0 0 11.467 0 0 0 0 0 0
0 SMINT20047290 20.756 0 0 0 0 0 0 0 0 0 0 0 0 SMINT20048720 0 0 0
16.241 0 0 0 7.849 12.12 0 0 0 0 SMINT20056240 12.1 16.438 0 0 0 0
0 0 0 0 0 0 0 SMINT20077920 29.636 11.503 0 5.439 0 5.246 18.009 0
8.118 5.432 8.529 0 0 SMINT20088690 0 0 0 0 0 0 0 0 50.098 0 0 0 0
SMINT20089210 5.552 0 0 7.133 0 0 0 0 0 7.123 22.369 10.807 0
SMINT20089600 0 0 0 0 0 18.533 0 0 28.682 0 0 0 0 SMINT20094150 0 0
0 0 0 0 0 0 0 0 0 0 73.849 SPLEN20005160 0 0 38.129 0 0 0 0 0 0
25.071 0 0 0 SPLEN20005370 0 0 0 0 0 0 69.313 0 0 0 0 0 0
SPLEN20012450 0 0 0 0 0 0 0 0 0 0 0 0 34.138
[1736] TABLE-US-00101 TABLE 34 SPLEN20024930 0 0 0 24.956 0 0 0 0 0
12.461 0 0 0 SPLEN20040780 32.496 0 31.704 0 0 0 0 0 0 0 0 0 0
SPLEN20048800 0 0 0 0 0 0 0 0.678 0 0 0 0 0 SPLEN20055600 0 0 0 0 0
0 0 0 67.066 0 0 0 0 SPLEN20057830 0 0 0 0 0 0 32.073 18.727 0 0 0
0 0 SPLEN20063250 0 0 0 0 0 0 0 0 0 0 4.267 0 0 SPLEN20071820 0 0 0
0 0 0 0 0 0 0 37.578 0 0 SPLEN20073880 0 0 0 0 0 0 0 0 28.031 0 0 0
0 SPLEN20076470 8.519 0 0 0 0 0 0 0 0 0 0 0 0 SPLEN20104690 0 0 0 0
0 0 0 56.874 0 0 0 0 0 SPLEN20114190 0 0 0 0 0 0 0 0 0 57.672 0 0 0
SPLEN20125230 0 0 0 21.397 0 0 0 41.362 0 0 0 0 0 SPLEN20135030 0 0
0 0 0 0 0 20.858 0 0 0 0 0 SPLEN20136700 0 0 0 22.036 0 0 0 0 0
22.006 0 0 0 SPLEN20175920 0 0 0 57.706 0 0 0 0 0 0 0 0 0
SPLEN20181570 3.585 0 0 0 0 0 0 0 0 0 0 0 0 SPLEN20183020 0 0 0 0 0
0 0 0 0 21.246 0 0 0 SPLEN20187490 0 0 0 0 0 0 0 22.776 0 0 0 0 0
SPLEN20193490 0 0 0 0 0 0 0 0 0 57.672 0 0 0 SPLEN20193790 0 0 0 0
0 0 0 0 0 0 0 0 10.329 SPLEN20197740 0 0 0 0 0 0 0 0 0 0 33.067 0 0
SPLEN20200070 0 0 0 0 67.502 0 0 0 0 0 0 0 0 SPLEN20200340 0 0 0 0
40.827 0 0 0 0 0 0 0 0 TESOP10000350 0 0 0 0 0 0 0 2.374 0 0 0
3.721 0 TESTI20005980 0 0 0 28.345 0 0 0 0 0 0 0 0 0 TESTI20030440
0 0 0 0 0 0 0 0 0 0 27.24 0 0 TESTI20030610 0 0 0 0 0 7.709 0 7.726
0 0 0 0 0 TESTI20031410 0 0 0 0 0 19.238 0 0 0 0 0 15.113 0
TESTI20035330 4.698 0 0 0 0 5.821 0 5.835 0 0 0 0 25.343
TESTI20047370 0 0 0 0 0 0 0 0 3.037 0 0 0 0 TESTI20050400 56.537 0
0 0 0 0 0 0 0 0 0 0 0 TESTI20050720 0 0 0 6.04 0 0 0 0 0 0 0 0 0
TESTI20053780 56.537 0 0 0 0 0 0 0 0 0 0 0 0 TESTI20057430 0 0 0
5.84 0 0 0 5.644 0 0 0 0 0 TESTI20057590 0 0 0 0 0 5.433 0 0 8.409
0 0 0 0 TESTI20057840 0 0 0 0 0 0 0 61.764 0 0 0 0 0 TESTI20057880
0 0 0 15.638 0 0 0 0 0 0 0 0 0
[1737] TABLE-US-00102 TABLE 35 TESTI20059080 0 5.993 0 0 25.882 0 0
5.478 8.458 0 0 0 0 TESTI20061200 0 9.745 0 0 0 8.888 0 0 0 0 0 0 0
TESTI20062580 0 0 0 0 0 0 31.15 0 28.084 0 29.506 0 0 TESTI20063410
0 0 0 9.861 0 9.51 0 0 14.718 9.848 0 0 0 TESTI20064530 0 0 0 0 0
2.635 0 0 0 5.458 0 0 0 TESTI20066280 0 0 0 0 0 0 33.259 0 0 0 0 0
0 TESTI20067480 9.289 6.31 0 11.934 0 0 0 5.768 0 0 0 0 0
TESTI20071630 0 0 0 62.564 0 0 0 0 0 0 0 0 0 TESTI20079980 6.472
8.793 6.314 0 0 4.009 6.883 12.056 0 4.152 0 0 0 TESTI20081890 0 0
0 0 0 61.711 0 0 0 0 0 0 0 TESTI20089290 0 63.862 0 0 0 0 0 0 0 0 0
0 0 TESTI20090180 0 0 0 21.786 0 0 0 0 0 0 0 0 0 TESTI20105130
2.549 0 2.487 0 4.986 0 0 1.583 0 1.635 0 0 0 TESTI20106170 0
18.661 13.402 0 0 8.51 14.608 0 0 26.436 0 0 0 TESTI20121040 0 0 0
18.021 0 0 0 0 0 0 0 0 0 TESTI20150920 0 0 0 0 17.606 0 0 0 17.261
0 18.135 0 0 TESTI20169500 17.008 0 0 0 0 0 0 0 0 0 0 0 0
TESTI20193080 0 0 0 0 0 0 0 0 0 62.532 0 0 0 TESTI20215310 0 0 0 0
0 0 0 0 0 0 0 71.689 0 TESTI20221790 0 0 0 0 0 0 0 37.573 0 0 0 0 0
TESTI20245860 0 0 0 62.564 0 0 0 0 0 0 0 0 0 TESTI20252690 0 33.792
0 0 0 0 0 0 0 0 0 0 0 TESTI20254090 0 0 0 0 0 12.041 0 24.136
18.635 0 0 0 0 TESTI20261160 0 0 0 0 0 0 0 35 0 0 0 0 0
TESTI20262150 0 0 42.353 0 0 0 0 0 0 0 0 0 0 TESTI20274960 0 0 0 0
0 0 0 0 0 38.341 0 0 0 THYMU20007750 0 0 0 29.606 0 0 0 0 0 0 0 0 0
THYMU20009460 0 16.274 0 0 0 0 0 0 0 0 0 0 0 THYMU20009710 0 0 0 0
0 0 0 0 0 0 0 0 83.62 THYMU20019260 15.885 0 0 0 0 0 0 0 30.461 0 0
0 0 THYMU20028410 13.579 0 0 0 0 16.825 0 0 0 0 0 0 0 THYMU20030460
0 0 0 4.612 0 0 0 0 0 4.606 0 0 0 THYMU20031330 0 0 0 0 0 0 0 0 0 0
0 0 39.843 THYMU20043440 0 0 0 0 0 29.394 0 0 0 0 0 0 0
THYMU20044100 0 0 0 28.394 0 0 0 27.444 0 0 0 0 0 THYMU20044520 0
28.839 0 0 0 26.302 0 0 0 0 0 0 0 THYMU20049060 0 0 0 0 0 0 0 0
64.474 0 0 0 0
[1738] TABLE-US-00103 TABLE 36 THYMU20055460 5.716 0 5.577 0 0 0 0
0 0 3.667 0 11.127 0 THYMU20055740 0 0 0 54.873 0 0 0 0 0 0 0 0 0
THYMU20071120 3.627 0 3.539 0 0 0 0 0 0 0 0 0 0 THYMU20078020 0
56.251 0 0 0 0 0 0 0 0 0 0 0 THYMU20089900 0 0 0 0 0 0 0 0 0 0
30.29 0 0 THYMU20091040 0 0 0 0 0 25.102 0 0 19.425 0 20.408 0 0
THYMU20104480 0 0 22.379 0 0 14.21 0 0 0 0 0 0 0 THYMU20120240
7.548 0 0 0 0 0 0 0 0 0 0 0 0 THYMU20139160 1.433 0.649 0.932 1.841
1.868 2.958 2.031 2.965 3.663 2.451 0 0 0 THYMU20143230 0 0 0 0 0
53.973 0 0 0 0 0 0 0 THYMU20150190 0 0 0 0 0 0 0 0 15.366 0 0 0
43.225 THYMU20157620 0 0 0 0 0 0 0 10.687 0 0 0 16.752 0
THYMU20176010 48.624 0 0 0 0 0 0 0 0 0 0 0 0 TKIDN10001920 15.885 0
0 0 0 0 0 0 30.461 0 0 0 0 TRACH20012490 0 0 0 0 0 8.484 0 0 0 0 0
0 0 TRACH20021000 0 14.835 0 0 0 0 0 0 0 0 0 0 58.903 TRACH20026640
0 0 0 7.419 0 0 0 0 0 0 0 0 0 TRACH20058000 0 0 0 0 0 23.543 0 0 0
0 0 0 0 TRACH20090060 0 0 0 0 0 6.122 0 0 0 0 0 0 0 TRACH20159390 0
0 0 0 0 0 0 34.053 0 0 0 0 0 UMVEN10001380 0 0 3.528 0 0 0 0 0 0 0
0 0 0 UTERU10001060 15.424 0 0 0 0 0 32.805 0 0 0 0 0 0
UTERU20000230 0 0 0 21.808 0 0 0 0 0 21.777 0 0 0 UTERU20000950
1.882 2.557 0 2.418 0 2.332 4.002 0 0 4.829 0 0 0 UTERU20026620
5.456 7.413 10.647 0 0 0 0 0 0 0 0 0 0 UTERU20041970 0 0 3.112 0 0
3.953 0 0 0 0 0 3.105 0 UTERU20065470 0 0 0 0 0 0 0 0 0 0 49.42 0 0
UTERU20079240 0 0 0 0 19.675 0 0 0 0 0 20.266 19.583 0
UTERU20083020 0 0 0 0 0 43.664 8.006 4.675 7.218 4.83 7.584 7.328 0
UTERU20089300 0 0 0 0 0 0 0 0 0 0 0 0 72.345 UTERU20089390 8.519 0
0 0 0 0 0 0 0 0 0 0 0 UTERU20095100 19.272 0 0 0 0 0 40.989 0 0 0 0
0 0 UTERU20102260 0 0 0 15.526 0 0 0 0 0 0 0 0 0 UTERU20103200 0 0
0 0 0 0 0 0 48.185 0 0 0 0 UTERU20127150 0 0 0 0 0 0 0 37.588 0 0 0
0 0 UTERU20128560 0 0 0 11.256 0 0 0 0 0 0 0 0 0
[1739] TABLE-US-00104 TABLE 37 Clone ID FEHRT HEART BRAMY20043630 0
7.465 BRAMY20072870 0 76.411 BRAMY20227860 0 2.943 BRAWH20093070 0
25.522 BRCAN10001680 0 14.799 FCBBF30053300 86.185 0 FEBRA20078800
0 33.301 FEBRA20090220 0 9.681 HCHON20000870 0 23.022 HEART10001420
0 100 HEART10001490 0 14.37 HEART20009590 0 100 HEART20019310 0 100
HEART20022200 0 100 HEART20031680 0 100 HEART20047640 0 100
HEART20063100 0 100 HEART20082570 0 100 HLUNG20083960 0 40.294
PLACE60088240 0 67.95 PLACE60120280 0 50.712 PROST20016760 0 8.491
PROST20035170 0 23.745 PROST20062820 0 67.646 PROST20127450 0
48.135 SKMUS20006790 0 5.186 SKMUS20008730 0 27.003 TESTI20270130 0
83.925
[1740] TABLE-US-00105 TABLE 38 Clone ID FEKID KIDNE ASTRO20009140 0
19.518 BGGI120010750 0 4.532 BRACE20054480 0 29.719 BRACE20062580 0
2.613 BRACE20219360 0 59.494 BRAMY20001510 68.103 0 BRAMY20003540 0
4.676 BRAMY20003880 0 16.882 BRAMY20043630 0 3.51 BRAMY20204270 0
3.618 CTONG20033750 0 59.93 CTONG20039370 0 59.93 CTONG20045500 0
59.93 FCBBF20023490 0 14.59 FEBRA20039260 0 7.084 FEBRA20040290 0
7.711 HEART10001490 0 20.269 HLUNG20041590 0 4.744 HLUNG20068120 0
11.84 HLUNG20072450 88.657 3.599 HLUNG20083960 0 18.946
KIDNE20011600 0 100 KIDNE20016360 0 59.589 KIDNE20024380 0 100
KIDNE20027980 0 100 KIDNE20080690 0 5.861 KIDNE20081170 0 100
KIDNE20083150 0 100 KIDNE20083620 0 100 KIDNE20084030 0 40.03
KIDNE20084040 0 34.084 KIDNE20084730 0 100 KIDNE20084800 0 100
KIDNE20086490 0 87.61 KIDNE20086660 0 47.013 KIDNE20086970 0 100
KIDNE20087880 0 28.683 KIDNE20088240 0 100 KIDNE20089870 0 3.987
KIDNE20091090 0 100 KIDNE20094260 0 100 KIDNE20094670 0 59.494
KIDNE20095530 0 100 KIDNE20133460 0 100 KIDNE20133880 0 100
KIDNE20134130 0 65.363 KIDNE20134890 0 100 KIDNE20137310 0 100
KIDNE20138450 0 38.971 KIDNE20140870 0 22.93 KIDNE20141120 0 100
KIDNE20141700 0 100 KIDNE20142680 0 100 KIDNE20142900 0 31.732
KIDNE20143200 0 100 KIDNE20147170 0 100 KIDNE20148080 0 100
KIDNE20149780 0 60.365 KIDNE20150730 0 100 KIDNE20152440 0 100
KIDNE20154330 0 100 KIDNE20154830 0 100 KIDNE20155980 0 100
KIDNE20157100 0 100 KIDNE20160360 0 100 KIDNE20160960 0 100
KIDNE20163710 0 100 KIDNE20165390 0 100 KIDNE20169180 0 100
KIDNE20170400 0 19.556 KIDNE20173150 0 100 KIDNE20173430 0 36.673
KIDNE20176030 0 100 KIDNE20181670 0 100 KIDNE20182540 0 100
KIDNE20186170 0 100 KIDNE20188630 0 100 KIDNE20189890 0 100
KIDNE20189960 0 100 KIDNE20191870 0 100 OCBBF20174890 0 32.241
PLACE60073090 0 10.501 PLACE60181870 0 49.921 PROST20016760 0 3.992
PUAEN10000650 0 6.676 SKNMC20006350 24.429 0 SPLEN20017610 0 42.429
SPLEN20063250 0 3.996 SPLEN20126110 0 50.05 SPLEN20135030 0 31.695
TESTI20061200 0 13.537 TESTI20262150 0 40.96 THYMU10004280 0 3.534
THYMU20139160 0 2.704 TRACH20011010 0 10.647
[1741] TABLE-US-00106 TABLE 39 Clone ID FELNG HLUNG BRAMY20001510 0
5.948 BRAMY20043630 0 15.102 BRAMY20204270 0 7.785 BRAMY20227860 0
1.488 CTONG20029030 0 28.504 CTONG20168460 0 76.291 CTONG20186290 0
61.67 FEBRA20039260 0 7.62 FEBRA20078800 0 33.686 FEBRA20163980 0
38.327 HCHON20000870 0 23.288 HLUNG20008460 0 67.54 HLUNG20009260 0
100 HLUNG20009550 0 100 HLUNG20010130 0 100 HLUNG20011260 0 100
HLUNG20011440 0 100 HLUNG20011460 0 76.577 HLUNG20012140 0 100
HLUNG20014590 0 36.045 HLUNG20015070 0 17.804 HLUNG20015180 0 4.723
HLUNG20020500 0 100 HLUNG20020850 0 67.488 HLUNG20021450 0 68.006
HLUNG20023030 0 100 HLUNG20024050 0 100 HLUNG20025620 0 100
HLUNG20028110 0 76.618 HLUNG20029420 0 100 HLUNG20029490 0 81.173
HLUNG20030420 0 100 HLUNG20030490 0 100 HLUNG20030610 0 100
HLUNG20031620 0 80.237 HLUNG20032460 0 44.037 HLUNG20033060 0
36.529 HLUNG20033310 0 100 HLUNG20033350 0 100 HLUNG20034970 0
79.349 HLUNG20037140 0 100 HLUNG20037160 0 100 HLUNG20037780 0
44.761 HLUNG20038330 0 100 HLUNG20041540 0 100 HLUNG20041590 0
10.207 HLUNG20042730 0 100 HLUNG20045340 0 7.67 HLUNG20047070 0 100
HLUNG20050760 0 100 HLUNG20051330 0 100 HLUNG20052300 0 23.611
HLUNG20054790 0 100 HLUNG20055240 0 100 HLUNG20056560 0 75.961
HLUNG20057380 0 100 HLUNG20059240 0 100 HLUNG20060670 0 100
HLUNG20063700 0 100 HLUNG20065700 0 62.8 HLUNG20065990 0 100
HLUNG20067810 0 100 HLUNG20068120 0 50.947 HLUNG20069350 0 100
HLUNG20070410 0 100 HLUNG20072100 0 54.241 HLUNG20072190 0 79.349
HLUNG20072450 0 7.744 HLUNG20074330 0 100 HLUNG20079310 0 100
HLUNG20081390 0 66.429 HLUNG20081530 0 100 HLUNG20082350 0 100
HLUNG20083330 0 100 HLUNG20083480 0 13.123 HLUNG20083840 0 100
HLUNG20083960 0 40.76 HLUNG20084790 0 100 HLUNG20085210 0 50.993
HLUNG20088750 0 100 HLUNG20092530 0 100 HLUNG20093030 0 100
HLUNG20094130 0 75.987 KIDNE20142900 0 68.268 PROST20016760 0 8.589
PROST20052850 0 57.701 SKNMC20006350 0 2.134 SMINT20035050 0 6.135
SPLEN20012450 0 25.695 TESTI20057590 0 17.804 TESTI20061200 0
29.123 TESTI20067480 0 18.856 TESTI20116050 0 30.168 THYMU10004280
0 7.603 THYMU20010180 0 79.349 THYMU20139160 0 1.939 TRACH20011010
0 22.907 UTERU20016580 0 43.64 UTERU20127030 0 66.318
[1742] TABLE-US-00107 TABLE 40 Alteration of the expression level
of each clone due to TNF-.alpha. stimulation to human monocyte cell
line THP-1 and alteration of the expression level of each clone due
to co- culture of gastric cancer cell line MKN45 with Helicobacter
pylori. ctl, TNF_1h, and TNF_3h in the column of THP-1,
respectively, indicate the relative mRNA expression levels in
unstimulated THP-1, in the cell stimulated with 10 ng/mL
TNF-.alpha. for 1 hour, and in the cell stimulated with 10 ng/mL
TNF-.alpha. for 3 hours; ctl, Hp, and .DELTA.cagE in the column of
MKN45 indicate the relative mRNA expression levels in MKN45
cultured without Helicobacter pylori, in the cells co-cultured with
cag PAI- positive Helicobacter pylori (TN2) (at a ratio of
MKN45:TN2 = 1:100 cells (colonies)) for 3 hours, and in the cells
co- cultured with the cagE mutant (TN2.DELTA.cagE) (at a ratio of
MKN45:TN2.DELTA.cagE = 1:100 cells (colonies)) for 3 hours,
respectively. [ATAC-PCR] THP-1 MKN45 Clone name ctl TNF_1h TNF_3h
ctl Hp .DELTA.cagE ASTRO20045840 1.5 2.3 1.9 2.3 2.4 0.2
ASTRO20055930 0.8 1.9 1.4 0.8 0.8 0.5 ASTRO20088950 1.0 0.2 2.5 1.1
0.3 0.3 BNGH420052350 2.2 2.2 0.0 0.5 0.5 3.2 BRACE20052530 2.6 1.0
0.3 2.2 1.0 0.9 BRACE20054080 0.8 1.1 1.0 BRAMY20003880 1.5 0.9 0.6
1.2 0.0 1.3 BRAMY20027390 0.6 4.2 0.1 2.9 0.4 0.1 BRAMY20028530 0.5
3.4 4.1 BRAMY20035380 1.3 0.9 0.8 0.5 1.7 0.5 BRAMY20036530 1.1 0.3
0.3 BRAMY20050940 0.4 0.0 0.0 0.2 0.2 1.0 BRAMY20072440 0.5 0.5 0.1
BRAMY20096930 3.8 5.2 4.7 1.7 2.4 1.7 BRAMY20118410 0.8 3.7 0.8 2.7
0.0 0.0 BRAMY20237190 0.0 2.3 0.1 BRAWH20055330 2.5 4.7 2.8 1.2 1.3
0.0 BRAWH20078620 1.9 1.2 1.0 BRAWH20190530 0.6 0.1 0.0 0.3 0.0 0.0
BRCAN20001480 1.0 3.4 4.1 1.4 1.6 0.6 BRHIP10000720 0.3 1.8 1.4 0.9
0.0 1.7 BRHIP10001040 0.9 0.7 0.1 0.0 0.1 0.0 BRHIP20000210 0.6 0.6
0.0 2.0 0.3 0.0 BRSSN20001970 0.8 1.4 1.3 0.8 0.7 0.5 BRSSN20091190
0.6 0.1 0.8 CD34C20001750 0.0 0.4 2.0 CTONG20078340 0.3 2.6 1.6 0.9
0.7 2.4 CTONG20079590 1.0 1.2 0.2 0.1 0.0 0.0 CTONG20083980 0.0 0.0
0.0 1.3 1.8 1.9 CTONG20085210 0.8 1.2 2.3 0.1 0.2 0.1 DFNES20063460
1.7 3.6 2.7 1.3 2.0 0.1 DFNES20072990 1.4 1.9 2.0 5.0 4.9 4.2
FCBBF20029280 1.8 5.5 3.8 2.3 2.2 2.3 FCBBF20032930 0.1 0.1 0.0 1.7
0.5 0.5 FCBBF20036360 0.6 0.7 0.4 0.4 0.2 0.2 FCBBF30022680 2.9 1.0
0.3 2.9 1.0 0.3 FCBBF30078600 1.1 2.6 0.6 FCBBF30105080 1.8 1.6 1.9
0.2 0.1 0.0 FCBBF30169870 1.1 1.2 0.2 1.6 0.3 0.3 FCBBF30225930 2.2
0.8 1.0 1.1 0.7 0.2 FCBBF50000610 2.1 2.8 2.2 2.0 2.2 1.3
FEBRA20007820 0.0 1.7 2.4 2.1 1.4 1.2 FEBRA20031280 0.1 1.8 4.5 0.5
0.0 0.0 FEBRA20031810 1.4 3.9 3.5 1.5 2.1 1.9 FEBRA20039260 2.0 3.0
2.5 FEBRA20046280 1.3 0.3 0.3 FEBRA20084750 2.5 2.2 0.3
FEBRA20182030 3.0 4.0 4.2 1.6 0.3 0.7 HLUNG20041540 0.0 2.2 2.2 1.9
2.4 0.2 HLUNG20092530 0.3 0.3 3.1 0.2 0.2 0.9 KIDNE20084030 1.6 0.1
0.3 0.1 0.0 0.0 KIDNE20084800 0.6 0.3 0.0 0.5 0.5 1.1 KIDNE20134130
0.4 0.4 0.5 2.3 1.2 1.6 KIDNE20182540 1.1 0.3 0.3 KIDNE20186170 0.0
0.0 0.0 0.6 0.0 0.0 KIDNE20188630 1.5 0.5 0.5 0.4 0.3 0.0
LIVER20007750 1.3 1.8 0.3 1.9 0.7 0.0 MESAN20021220 1.7 2.6 1.6 2.3
0.9 0.3 MESAN20084150 0.8 2.6 2.2 1.7 2.1 1.1 NT2NE20059210 1.4 0.4
0.1 NT2NE20082130 1.8 1.3 0.5 1.9 0.3 0.3 NT2NE20092950 1.3 2.7 3.4
1.7 2.4 1.8 NT2RP70031070 0.3 0.9 1.4 0.4 0.4 0.0 OCBBF20012520 0.3
0.3 1.3 0.9 0.2 1.2 OCBBF20110210 4.5 1.8 0.5 0.5 0.5 4.5
OCBBF20110730 0.4 0.5 0.3 0.1 0.0 0.0 OCBBF20155030 1.1 1.1 0.9 2.5
0.8 0.3 OCBBF20165900 1.7 4.4 4.4 1.9 3.3 1.1 OCBBF20170350 0.9 5.4
0.3 0.3 1.7 1.5 OCBBF20176650 0.5 1.3 0.5 0.7 0.7 0.0 PLACE60006300
0.8 3.2 1.0 0.5 0.5 0.9 PLACE60061370 2.7 0.8 1.5 1.2 1.0 1.3
PROST20011160 0.2 1.7 2.0 1.3 5.5 1.7 PROST20041460 2.9 0.1 1.5 0.6
0.0 0.0 PROST20065100 1.4 1.9 1.6 5.3 0.0 0.0 PROST20075280 1.7 0.5
0.5 2.6 0.5 0.5 PROST20106060 0.2 0.2 2.0 1.0 0.6 0.7 PROST20110120
1.2 0.6 0.5 SKMUS20091900 1.2 1.6 0.3 1.2 2.6 0.3 SMINT20024140 0.0
0.1 0.0 SMINT20092160 0.5 0.7 0.3 1.3 1.2 0.3 SPLEN20040780 1.0 2.8
1.9 0.3 0.8 0.1 SPLEN20110860 2.4 0.1 7.6 1.4 0.1 0.1 SPLEN20177400
0.8 3.3 1.3 1.3 0.7 0.3 TESTI20038240 0.1 0.0 0.0 TESTI20043130 0.0
0.1 0.7 TESTI20046540 1.1 0.8 0.2 1.1 0.8 0.3 TESTI20047370 0.4 0.4
0.5 0.6 0.0 0.5 TESTI20057200 2.5 0.0 1.2 1.1 0.4 0.3 TESTI20057590
0.1 0.1 0.0 3.8 3.5 2.2 TESTI20113940 5.2 0.2 0.2 4.4 0.4 0.4
TESTI20149880 2.2 0.2 2.2 TESTI20151800 2.1 3.3 2.3 2.5 1.0 0.3
TESTI20173050 0.8 0.6 0.5 1.8 1.1 1.0 TESTI20198600 2.2 0.2 2.2
TESTI20257910 1.2 0.3 0.3 1.2 0.2 0.7 TESTI20262940 1.5 1.1 0.2 1.1
1.3 0.2 THYMU20046770 1.7 0.5 0.5 THYMU20058550 1.9 0.1 0.1
THYMU20062520 0.0 0.0 0.7 0.2 0.3 0.1 THYMU20062770 1.6 1.0 0.3
THYMU20078240 0.3 1.7 2.9 0.0 1.0 0.1 THYMU20150190 0.2 0.2 0.6 1.4
0.5 1.9 TRACH20125620 1.1 2.5 1.5 1.4 1.4 1.0 TRACH20149740 9.4 9.4
0.9 1.6 2.1 0.6 TRACH20190460 2.0 3.3 3.1 0.2 1.1 0.2 UTERU20045200
1.4 2.6 3.9 0.9 2.1 2.5 UTERU20064120 0.6 2.7 2.0 0.6 1.7 0.4
UTERU20103200 0.1 0.0 0.9 2.4 1.7 0.9 ADRGL20046760 0.5 0.5 0.5
ASTRO20055530 0.7 2.4 1.7 0.8 2.1 1.6 BRAMY20076130 0.1 1.4 0.2 0.1
0.0 0.0 CTONG20170940 1.6 0.8 0.3 0.5 9.9 0.5 FCBBF20033360 0.1 0.4
1.4 6.4 0.3 0.7 FCBBF30257370 2.7 0.3 0.3 2.2 0.1 2.2 FCBBF50001650
1.0 1.6 1.2 1.3 1.0 0.9 FEBRA20040290 0.4 1.9 1.1 0.4 1.5 1.4
FEBRA20063720 2.9 3.3 3.1 1.5 0.7 1.4 FEBRA20098040 2.5 2.1 1.5 4.2
0.0 0.3 FEBRA20108580 1.4 2.8 2.8 0.7 0.2 0.2 MESAN20021860 0.1 1.2
0.2 0.9 1.0 0.9 MESAN20067430 0.8 3.0 1.5 0.0 0.3 0.0 NT2NE20045190
0.7 0.2 0.2 0.8 0.6 0.2 PROST20016760 1.1 3.4 2.3 SKNSH20007160 0.6
0.3 0.2 1.1 0.7 0.6 SMINT20006020 2.5 1.0 0.3 2.4 0.3 0.3
TESTI20059370 0.0 0.2 0.3 0.0 0.0 0.0 TESTI20103690 0.0 0.0 0.0 0.8
0.3 0.3 TESTI20254480 0.0 0.1 0.6 0.8 0.6 0.0 THYMU10004280 0.2 2.2
0.2 0.2 1.1 1.4 THYMU20030460 0.2 0.6 0.2 0.6 0.8 2.4 TRACH20090060
0.5 0.3 2.0 0.0 6.8 1.7 UTERU20041970 1.6 1.1 1.5 0.0 3.5 2.4
BRAMY20125360 0.8 1.6 1.1 0.0 0.0 0.0 OCBBF20142290 0.2 0.9 0.3 0.1
0.4 0.0 SKMUS20006790 0.7 0.5 0.3 1.0 0.8 0.7 TESTI20030610 0.1 2.0
1.7 0.0 0.3 0.0 UTERU20026620 0.4 4.2 4.2 2.4 2.7 0.9
Homology Search Result Data
[1743] Data obtained by the homology search for full-length
nucleotide sequences and deduced amino acid sequences.
[1744] In the result of the search shown below, both units, aa and
bp, are used as length units for the sequences to be compared.
[1745] Each data includes Clone name, Definition in hit data, P
value, Length of sequence to be compared, Homology, and Accession
number (No.) of hit data. These items are shown in this order and
separated by a double-slash mark, //. [1746] ADRGL20020290//Human
placental equilibrative nucleoside transporter 1 (hENT1) mRNA,
complete cds.//1.70E-240//456aa//100%//U81375 [1747]
ADRGL20021910//Homo sapiens transmembrane protein B7-H2 ICOS ligand
mRNA, complete cds.//2.50E-88//168aa//100%//AAG01176 [1748]
ADRGL20022600//DIAPHANOUS PROTEIN HOMOLOG 1
(P140MDIA).//2.00E-07//121aa//36%//008808 [1749]
ADRGL20023920//ABC1 PROTEIN HOMOLOG
PRECURSOR.//1.40E-98//467aa//45%//Q92338 [1750] ADRGL20026790//Homo
sapiens PLIC-1 mRNA, complete cds.//6.10E-05//169aa//31%//AF293384
[1751] ADRGL20027530 [1752] ADRGL20036380 [1753] ADRGL20036840//HLA
CLASS I HISTOCOMPATIBILITY ANTIGEN, ALPHA CHAIN H PRECURSOR
(HLA-AR) (HLA-12.4).//7.30E-68//131aa//96%//P01893 [1754]
ADRGL20040310 [1755] ADRGL20040770 [1756] ADRGL20046760 [1757]
ADRGL20047080 [1758] ADRGL20047770 [1759] ADRGL20057560 [1760]
ADRGL20059610//GLUCOSYLCERAMIDASE PRECURSOR (EC 3.2.1.45)
(BETA-GLUCOCEREBROSIDASE) (ACID BETA-GLUCOSIDASE)
(D-GLUCOSYL-N-ACYLSPHINGOSINE GLUCOHYDROLASE) (ALGLUCERASE)
(IMIGLUCERASE).//3.00E-94//188aa//93%//P04062 [1761]
ADRGL20062330//Homo sapiens trabeculin-alpha mRNA, complete
cds.//1.10E-128//439aa//58%//AF141968 [1762] ADRGL20063770 [1763]
ADRGL20066770//elastin microfibril interface located protein [Homo
sapiens].//3.00E-31//210aa//44%//NP.sub.--008977 [1764]
ADRGL20067320 [1765] ADRGL20079060//Mus musculus mRNA for Ky
protein (muscle-specific protein).//3.80E-266//281aa//84%//AJ293727
[1766] ADRGL20095330 [1767] ASTRO20001910//Rattus norvegicus mRNA
for annexin V-binding protein (ABP-10), partial
cds.//2.20E-57//153aa//73%//D64062 [1768] ASTRO20003720 [1769]
ASTRO20004820 [1770] ASTRO20006530//Homo sapiens hook1 protein
(HOOK1) mRNA, complete cds.//1.80E-94//383aa//55%//AF044923 [1771]
ASTRO20009140//PUTATIVE COMPETENCE-DAMAGE
PROTEIN.//2.70E-06//167aa//29%//P46323 [1772] ASTRO20010010 [1773]
ASTRO20010290 [1774] ASTRO20012270 [1775] ASTRO20020240 [1776]
ASTRO20020350 [1777] ASTRO20022020 [1778] ASTRO20026320//NAM7
PROTEIN (NONSENSE-MEDIATED mRNA DECAY PROTEIN 1) (UP-FRAMESHIFT
SUPPRESSOR 1).//1.80E-47//432aa//33%//P30771 [1779] ASTRO20027330
[1780] ASTRO20038400//Homo sapiens zinc finger homeobox protein
ZHX1 mRNA, complete cds.//3.40E-78//282aa//42%//AF106862 [1781]
ASTRO20045840 [1782] ASTRO20046280//PSU1
PROTEIN.//1.30E-42//228aa//36%//P53550 [1783] ASTRO20047510 [1784]
ASTRO20050810//L-RIBULOKINASE (EC
2.7.1.16).//1.10E-43//512aa//30%//P94524 [1785]
ASTRO20052420//PROBABLE GUANINE NUCLEOTIDE REGULATORY PROTEIN TIM
(ONCOGENE TIM) (P60 TIM) (TRANSFORMING IMMORTALIZED MAMMARY
ONCOGENE).//4.80E-151//408aa//76%//Q12774 [1786]
ASTRO20053430//BAND 4.1-LIKE PROTEIN 4 (NBL4
PROTEIN).//1.80E-58//307aa//38%//057457 [1787] ASTRO20055530 [1788]
ASTRO20055570//MAJOR PRION PROTEIN PRECURSOR (PRP) (PRP27-30)
(PRP33-35C) (ASCR).//5.40E-72//137aa//100%//P04156 [1789]
ASTRO20055930 [1790] ASTRO20058960//DNA damage inducible protein
homolog--fission yeast (Schizosaccharomyces
pombe)//1.90E-14//205aa//31%//T39541 [1791] ASTRO20069200 [1792]
ASTRO20075150//TNF RECEPTOR ASSOCIATED FACTOR 3 (CD40 RECEPTOR
ASSOCIATED FACTOR 1) (CRAF1) (CD40 BINDING PROTEIN) (CD40BP) (LMP1
ASSOCIATED PROTEIN) (LAP1).//1.00E-25//60aa//98%//Q13114 [1793]
ASTRO20076660 [1794] ASTRO20085080//TIPD
PROTEIN.//1.80E-58//307aa//37%//015736 [1795]
ASTRO20088950//LACTASE-PHLORIZIN HYDROLASE PRECURSOR
(LACTASE-GLYCOSYLCERAMIDASE) [INCLUDES: LACTASE (EC 3.2.1.108);
PHLORIZIN HYDROLASE (EC 3.2.1.62)].//7.80E-85//331aa//48%//P09848
[1796] ASTRO20089600//Mus musculus sacsin gene, complete
cds.//1.10E-05//198aa//26%//AF193557 [1797] ASTRO20090680//M.
musculus mRNA for IB3/5-polypeptide.//1.60E-173//412aa//78%//X79131
[1798] ASTRO20091180 [1799] ASTRO20091770 [1800] ASTRO20141740
[1801] BGGI120000670//Rattus norvegicus myosin heavy chain Myr 8b
mRNA, complete cds.//1.60E-05//86aa//36%//AY004215 [1802]
BGGI120010750//Rattus norvegicus mRNA for SECIS binding protein 2
(sbp2 gene).//7.90E-305//812aa//71%//AJ251245 [1803] BNGH410000570
[1804] BNGH420008150//Human SH3 domain-containing proline-rich
kinase (sprk) mRNA, complete cds.//3.40E-139//326aa//82%//U07747
[1805] BNGH420014060 [1806] BNGH420015760//Mus musculus mRNA for
JNK-binding protein JNKBP1, complete
cds.//1.60E-130//381aa//60%//AB029482 [1807] BNGH420021680 [1808]
BNGH420023870//RIBONUCLEASE
INHIBITOR.//4.70E-41//314aa//34%//P10775 [1809] BNGH420024870
[1810] BNGH420035290//MYOSIN HEAVY CHAIN KINASE B (EC 2.7.1.129)
(MHCK B).//7.60E-37//273aa//35%//P90648 [1811] BNGH420036410 [1812]
BNGH420040760 [1813] BNGH420042910 [1814] BNGH420045380 [1815]
BNGH420046790//immunoglobulin lambda light chain variable region
[Homo sapiens].//5.00E-47//84aa//100%//AAG24674 [1816]
BNGH420052350 [1817] BNGH420059680//DIPZ
PROTEIN.//3.00E-13//166aa//31%//Q10801 [1818] BNGH420061350 [1819]
BNGH420062340 [1820] BNGH420070370//ZINC FINGER PROTEIN GLI1
(GLI).//3.20E-65//165aa//59%//P47806 [1821]
BNGH420074600//DNA-DIRECTED RNA POLYMERASE III 128 KDA POLYPEPTIDE
(EC 2.7.7.6) (RNA POLYMERASE III SUBUNIT
2).//5.40E-214//522aa//72%//P25167 [1822] BNGH420075940 [1823]
BNGH420077980//Rattus norvegicus ankyrin binding cell adhesion
molecule neurofascin mRNA, alternatively spliced form, partial
cds.//0//588aa//98%//U81036 [1824] BNGH420085100 [1825]
BNGH420086030//N-CHIMAERIN (NC) (N-CHIMERIN) (ALPHA CHIMERIN)
(A-CHIMAERIN).//2.30E-21//130aa//40%//P15882 [1826]
BNGH420087430//Mus musculus mRNA 1 for phtf
protein.//5.80E-118//237aa//57%//AJ133721 [1827]
BRACE10000510//KERATIN, ULTRA HIGH-SULFUR MATRIX PROTEIN (UHS
KERATIN).//4.70E-12//132aa//37%//P26371 [1828] BRACE20003310//ZINC
FINGER PROTEIN 85 (ZINC FINGER PROTEIN HPF4)
(HTF1).//1.00E-205//504aa//71%//Q03923 [1829] BRACE20007330//RING
CANAL PROTEIN (KELCH PROTEIN).//4.60E-66//562aa//31%//Q04652 [1830]
BRACE20009050 [1831] BRACE20014450//Mus musculus mRNA for Ndr1
related protein Ndr2, complete
cds.//3.20E-150//291aa//95%//AB033921 [1832] BRACE20017790 [1833]
BRACE20018810 [1834] BRACE20025820 [1835] BRACE20038920 [1836]
BRACE20050870//PRE-mRNA SPLICING HELICASE BRR2 (EC
3.6.1.-).//8.40E-59//584aa//31%//P32639 [1837] BRACE20051600 [1838]
BRACE20051930//NEUROPILIN PRECURSOR (A5 PROTEIN) (A5
ANTIGEN).//5.50E-20//179aa//30%//P28824 [1839] BRACE20052430//Homo
sapiens AMSH mRNA, complete cds.//4.30E-75//272aa//53%//U73522
[1840] BRACE20052530 [1841] BRACE20054080 [1842] BRACE20054480
[1843] BRACE20054600//Xenopus laevis mRNA for Kielin, complete
cds.//4.30E-70//205aa//60%//AB026192 [1844] BRACE20055560 [1845]
BRACE20057870 [1846] BRACE20059110 [1847] BRACE20059810 [1848]
BRACE20061620//ZINC-BINDING PROTEIN
A33.//3.60E-30//329aa//28%//Q02084 [1849] BRACE20062580 [1850]
BRACE20063540//MEROZOITE SURFACE PROTEIN CMZ-8
(FRAGMENT).//1.60E-10//164aa//35%//P09125 [1851]
BRACE20065470//Xenopus laevis ubiquitin-like fusion protein mRNA,
complete cds.//6.70E-63//170aa//71%//L08474 [1852] BRACE20066360
[1853] BRACE20068710 [1854] BRACE20069000//CLN3 PROTEIN (BATTENIN)
(BATTEN'S DISEASE PROTEIN).//1.20E-147//279aa//100%//Q13286 [1855]
BRACE20069110 [1856] BRACE20069440 [1857] BRACE20079200//Xenopus
laevis mRNA for Kielin, complete
cds.//3.10E-15//63aa//58%//AB026192 [1858]
BRACE20079370//microtubule associated-protein orbit [Drosophila
melanogaster].//8.00E-42//282aa//36%//BAA94248 [1859]
BRACE20097540//Homo sapiens protein serine/threonine phosphatase 4
regulatory subunit 1 (PP4R1) mRNA, complete
cds.//2.80E-96//193aa//96%//AF111106 [1860] BRACE20098860 [1861]
BRACE20099070 [1862] BRACE20194670//UDP-GALACTOSE TRANSLOCATOR
(UDP-GALACTOSE TRANSPORTER) (UGT)
(UDP-GAL-TR).//1.40E-32//72aa//98%//P78381 [1863]
BRACE20196180//Homo sapiens HMG domain protein HMGX2 (HMGX2) mRNA,
complete cds.//6.90E-154//235aa//91%//AF146223 [1864] BRACE20196960
[1865] BRACE20200770//PROTEIN MOV-10.//3.30E-24//113aa//50%//P23249
[1866] BRACE20200970 [1867] BRACE20204670//PROTEIN-TYROSINE
PHOSPHATASE ALPHA PRECURSOR (EC 3.1.3.48)
(R-PTP-ALPHA).//4.30E-237//428aa//99%//P18433 [1868] BRACE20205840
[1869] BRACE20207420 [1870] BRACE20212450 [1871]
BRACE20215410//PROTEIN-TYROSINE PHOSPHATASE YVH1 (EC 3.1.3.48)
(PTPASE YVH1).//2.90E-08//136aa//31%//Q02256 [1872] BRACE20216700
[1873] BRACE20216950//4F2 CELL-SURFACE ANTIGEN HEAVY CHAIN (4F2HC)
(LYMPHOCYTE ACTIVATION ANTIGEN 4F2 LARGE SUBUNIT) (4F2 HEAVY CHAIN
ANTIGEN) (CD98 ANTIGEN).//4.80E-66//94aa//90%//P08195 [1874]
BRACE20219360 [1875] BRAMY10000980 [1876] BRAMY10001730 [1877]
BRAMY20000210 [1878] BRAMY20000250 [1879] BRAMY20001510//Homo
sapiens RING zinc finger protein (RZF) mRNA, complete
cds.//3.80E-131//245aa//99%//AF037204 [1880]
BRAMY20003540//1-PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE
PHOSPHODIESTERASE DELTA 1 (EC 3.1.4.11) (PLC-DELTA-1)
(PHOSPHOLIPASE C-DELTA-1) (PLC-III).//0//745aa//99%//P51178 [1881]
BRAMY20003880 [1882] BRAMY20005080//UBIQUITIN CARBOXYL-TERMINAL
HYDROLASE 16 (EC 3.1.2.15) (UBIQUITIN THIOLESTERASE 16)
(UBIQUITIN-SPECIFIC PROCESSING PROTEASE 16) (DEUBIQUITINATING
ENZYME 16) (UBIQUITIN PROCESSING PROTEASE
UBP-M).//2.70E-46//93aa//100%//Q9Y5T5 [1883] BRAMY20013670//PECANEX
PROTEIN.//1.80E-84//300aa//56%//P18490 [1884] BRAMY20016780 [1885]
BRAMY20020440 [1886] BRAMY20021580 [1887] BRAMY20023390 [1888]
BRAMY20023640 [1889] BRAMY20024790 [1890] BRAMY20027390 [1891]
BRAMY20027990//Homo sapiens NEDL1 mRNA for NEDD4-like ubiquitin
ligase 1, complete cds.//4.60E-158//294aa//100%//AB048365 [1892]
BRAMY20028530 [1893] BRAMY20028620//NICOTINATE-NUCLEOTIDE
PYROPHOSPHORYLASE [CARBOXYLATING] (EC 2.4.2.19) (QUINOLINATE
PHOSPHORIBOSYLTRANSFERASE [DECARBOXYLATING])
(QAPRTASE).//9.70E-18//53aa//84%//Q15274 [1894] BRAMY20035380//ZINC
TRANSPORTER 1 (ZNT-1).//5.60E-40//211aa//35%//Q62720 [1895]
BRAMY20035830//Homo sapiens RCC1-like G exchanging factor RLG mRNA,
complete cds.//3.60E-103//251aa//75%//AF060219 [1896] BRAMY20036530
[1897] BRAMY20036810 [1898] BRAMY20038980//INTRACELLULAR PROTEIN
TRANSPORT PROTEIN US01.//3.40E-17//407aa//23%//P25386 [1899]
BRAMY20039290 [1900] BRAMY20040580//ZINC FINGER PROTEIN
135.//1.70E-29//115aa//54%//P52742 [1901] BRAMY20043520 [1902]
BRAMY20043630//Homo sapiens Ras-binding protein SUR-8 mRNA,
complete cds.//1.30E-167//364aa//88%//AF068920
BRAMY20044920//UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 4 (EC
3.1.2.15) (UBIQUITIN THIOLESTERASE 4) (UBIQUITIN-SPECIFIC
PROCESSING PROTEASE 4) (DEUBIQUITINATING ENZYME 4) (UBIQUITOUS
NUCLEAR PROTEIN HOMOLOG).//7.60E-28//86aa//47%//Q13107 [1903]
BRAMY20045210 [1904] BRAMY20045420 [1905] BRAMY20047560 [1906]
BRAMY20050640 [1907] BRAMY20050940 [1908] BRAMY20051820//Human mRNA
for Doc2 (Double C2), complete cds.//1.90E-49//102aa//99%//D31897
[1909] BRAMY20052440 [1910] BRAMY20053910 [1911]
BRAMY20055760//POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE VA (EC
3.6.1.-).//5.80E-130//393aa//59%//054827 [1912] BRAMY20056620//Homo
sapiens mccb mRNA for non-biotin containing subunit of
3-methylcrotonyl-CoA carboxylase, complete
cds.//3.00E-106//203aa//100%//AB050049 [1913]
BRAMY20056840//UBE-1c2//2.40E-74//261aa//53%//AB030505 [1914]
BRAMY20063750//Homo sapiens HRIHFB2007 mRNA, partial
cds.//3.40E-139//253aa//99%//AB015330 [1915] BRAMY20072440 [1916]
BRAMY20072870//ACETYL-COENZYME A SYNTHETASE (EC 6.2.1.1)
(ACETATE-COA LIGASE) (ACYL-ACTIVATING
ENZYME).//2.50E-15//88aa//46%//P16929 [1917] BRAMY20073080 [1918]
BRAMY20074110 [1919] BRAMY20074860 [1920]
BRAMY20076100//STEROIDOGENIC FACTOR 1 (STF-1) (SF-1) (STEROID
HORMONE RECEPTOR AD4BP) (FUSHI TARAZU FACTOR HOMOLOG
1).//4.80E-66//132aa//94%//P50569 [1921] BRAMY20076130 [1922]
BRAMY20076530 [1923] BRAMY20083330//SYNAPSIN
I.//4.50E-05//155aa//29%//P17599 [1924] BRAMY20083820 [1925]
BRAMY20089770//P2X PURINOCEPTOR 7 (ATP RECEPTOR) (P2.times.7)
(PURINERGIC RECEPTOR) (P2Z
RECEPTOR).//3.30E-136//242aa//99%//Q99572 [1926]
BRAMY20091230//MITOCHONDRIAL UNCOUPLING PROTEIN 4 (UCP
4).//4.60E-121//224aa//100%//095847 [1927] BRAMY20093490//Mus
musculus ubiquitin-protein ligase E3-alpha (Ubr1) mRNA, complete
cds.//7.80E-43//139aa//55%//AF061555 [1928] BRAMY20094890//A KINASE
ANCHOR PROTEIN 4 PRECURSOR (MAJOR FIBROUS SHEATH PROTEIN) (FSC1)
(P82).//4.60E-06//131aa//27%//Q60662 [1929] BRAMY20095080 [1930]
BRAMY20095570 [1931] BRAMY20096930//Torpedo marmorata mRNA for male
sterility protein 2-like protein (ms21
gene).//2.00E-63//139aa//82%//AJ272073 [1932] BRAMY20100680 [1933]
BRAMY20102900//Homo sapiens RU1 (RU1) mRNA, complete
cds.//1.20E-47//151aa//58%//AF168132 [1934] BRAMY20107980 [1935]
BRAMY20111780//ZINC FINGER PROTEIN
135.//1.00E-139//416aa//57%//P52742 [1936] BRAMY20117670//Mus
musculus mmDNAJA4 mRNA for mmDj4, complete
cds.//3.20E-118//239aa//90%//AB032401 [1937] BRAMY20118410 [1938]
BRAMY20118490//GLYCEROL KINASE 2 (EC 2.7.1.30) (ATP:GLYCEROL
3-PHOSPHOTRANSFERASE 2) (GLYCEROKINASE 2) (GK
2).//1.80E-48//247aa//40%//Q9X1E4 [1939] BRAMY20120170 [1940]
BRAMY20123400 [1941] BRAMY20124970 [1942] BRAMY20125170 [1943]
BRAMY20125360//L-ASPARAGINASE (EC 3.5.1.1) (L-ASPARAGINE
AMIDOHYDROLASE).//3.30E-53//148aa//43%//Q9ZSD6 [1944]
BRAMY20125550//Homo sapiens mRNA for 28 kD interferon responsive
protein (IFRG28 gene).//4.40E-16//155aa//33%//AJ251832 [1945]
BRAMY20126910 [1946] BRAMY20127310 [1947] BRAMY20127760 [1948]
BRAMY20134050//NUCLEOSOME ASSEMBLY PROTEIN 1-LIKE 2 (BRAIN-SPECIFIC
PROTEIN, X-LINKED).//1.40E-25//109aa//56%//P51860 [1949]
BRAMY20135720 [1950] BRAMY20137360//Homo sapiens gene for
TU12B1-TY, exon 12 and complete
cds.//2.10E-18//257aa//31%//AB032786 [1951] BRAMY20139440 [1952]
BRAMY20139750 [1953] BRAMY20143870//PEPTIDYL-TRNA HYDROLASE (EC
3.1.1.29) (PTH).//5.80E-27//182aa//35%//P96386 [1954]
BRAMY20152510//PROTEIN-TYROSINE PHOSPHATASE STRIATUM-ENRICHED (EC
3.1.3.48) (STEP) (NEURAL-SPECIFIC PROTEIN-TYROSINE PHOSPHATASE)
(FRAGMENT).//4.80E-293//537aa//97%//P54829 [1955] BRAMY20155500
[1956] BRAMY20158550//CALMODULIN.//1.60E-15//116aa//42%//P04352
[1957] BRAMY20159250 [1958] BRAMY20160020 [1959] BRAMY20173480
[1960] BRAMY20190550//EPIDERMAL GROWTH FACTOR RECEPTOR SUBSTRATE
SUBSTRATE 15 (PROTEIN EPS15) (AF-1P
PROTEIN).//2.20E-226//464aa//89%//P42566 [1961] BRAMY20194680
[1962] BRAMY20204270 [1963] BRAMY20206340//GUANINE
NUCLEOTIDE-BINDING PROTEIN BETA SUBUNIT-LIKE
PROTEIN.//4.20E-07//151aa//27%//P38011 [1964] BRAMY20219620 [1965]
BRAMY20221600//H. sapiens mRNA for novel T-cell activation
protein.//1.60E-130//245aa//99%//X94232 [1966] BRAMY20223010//Mus
musculus leucine-rich glioma-inactivated 1 protein precursor,
(Lgi1) mRNA, complete cds.//2.00E-79//269aa//52%//AF246818
[1967] BRAMY20225250 [1968] BRAMY20225320 [1969] BRAMY20227230
[1970] BRAMY20227860//Homo sapiens dickkopf-3 (DKK-3) mRNA,
complete cds.//2.30E-69//147aa//92%//AF177396 [1971] BRAMY20227960
[1972] BRAMY20231150//PUTATIVE ACID PHOSPHATASE F26C11.1 (EC
3.1.3.2).//2.30E-55//322aa//39%//Q09549 [1973] BRAMY20234820//Homo
sapiens mitotic checkpoint protein (MAD1) mRNA, complete
cds.//1.30E-286//561aa//100%//AF123318 [1974] BRAMY20237190 [1975]
BRAMY20238630//TETRATRICOPEPTIDE REPEAT PROTEIN
4.//1.20E-147//276aa//99%//095801 [1976] BRAMY20243120 [1977]
BRAMY20244490//ADENYLATE KINASE ISOENZYME 1 (EC 2.7.4.3) (ATP-AMP
TRANSPHOSPHORYLASE) (AK1)
(MYOKINASE).//2.50E-19//119aa//37%//P00571 [1978]
BRAMY20245140//Rattus norvegicus potassium channel (erg2) mRNA,
complete cds.//1.00E-178//427aa//81%//AF016192 [1979] BRAMY20245350
[1980] BRAMY20245760//Araneus diadematus fibroin-4 mRNA, partial
cds.//7.90E-05//285aa//22%//U47856 [1981] BRAMY20251210//EPHRIN
TYPE-A RECEPTOR 7 PRECURSOR (EC 2.7.1.112) (TYROSINE-PROTEIN KINASE
RECEPTOR EHK-3) (EPH HOMOLOGY KINASE-3) (EMBRYONIC BRAIN KINASE)
(EBK) (DEVELOPMENTAL KINASE 1)
(MDK-1).//3.80E-94//268aa//66%//Q61772 [1982] BRAMY20251750//Homo
sapiens BRI3 mRNA, complete cds.//2.80E-131//242aa//95%//AF272043
[1983] BRAMY20263000//DYSTROPHIA MYOTONICA-CONTAINING WD REPEAT
MOTIF PROTEIN (DMR-N9 PROTEIN).//2.60E-134//430aa//59%//Q08274
[1984] BRAMY20267780 [1985] BRAMY20269040 [1986] BRAMY20271140
[1987] BRAMY20274510//60S RIBOSOMAL PROTEIN
L12.//1.10E-39//102aa//82%//P30050 [1988] BRAMY20285650 [1989]
BRAMY20287400 [1990] BRAWH20014590//ZAKI-4
PROTEIN.//3.10E-92//187aa//93%//Q14206 [1991] BRAWH20020470 [1992]
BRAWH20020600 [1993] BRAWH20021910//FATTY ACYL-COA HYDROLASE
PRECURSOR, MEDIUM CHAIN (EC 3.1.2.14) (THIOESTERASE
B).//1.30E-111//450aa//49%//Q04791 [1994] BRAWH20025490 [1995]
BRAWH20026010//AD021 protein [Homo
sapiens]//4.00E-55//245aa//44%//NP.sub.--057697 [1996]
BRAWH20027250 [1997] BRAWH20030000 [1998] BRAWH20039640//SLIT
PROTEIN PRECURSOR.//6.10E-19//282aa//31%//P24014 [1999]
BRAWH20040680//PUTATIVE TRANSCRIPTION ELONGATION FACTOR S-II
(TFIIS).//5.90E-06//179aa//29%//P52652 [2000] BRAWH20047790 [2001]
BRAWH20050740//ZINC FINGER PROTEIN 151 (POLYOMAVIRUS LATE INITIATOR
PROMOTER BINDING PROTEIN) (LP-1) (ZINC FINGER PROTEIN
Z13).//1.60E-16//235aa//30%//Q60821 [2002] BRAWH20055240 [2003]
BRAWH20055330 [2004] BRAWH20055780 [2005] BRAWH20058120 [2006]
BRAWH20063010//SPLICEOSOME ASSOCIATED PROTEIN 49 (SAP 49)
(SF3B53).//2.60E-06//121aa//33%//Q15427 [2007] BRAWH20078080 [2008]
BRAWH20078620 [2009] BRAWH20080580//ZINC FINGER PROTEIN 84 (ZINC
FINGER PROTEIN HPF2).//1.00E-116//316aa//63%//P51523 [2010]
BRAWH20082550 [2011] BRAWH20082920//Human TFIIIC Box B-binding
subunit mRNA, complete cds.//1.90E-36//72aa//100%//U02619 [2012]
BRAWH20093040//PROTEIN KINASE CLK2 (EC
2.7.1.-).//2.70E-86//162aa//96%//P49760
BRAWH20093070//SYNAPSIN.//4.80E-06//245aa//28%//Q24546 [2013]
BRAWH20094900//Mus musculus mRNA for sialidase, complete
cds.//5.70E-73//310aa//50%//AB026842 [2014] BRAWH20095900//ZINC
FINGER PROTEIN 184 (FRAGMENT).//1.20E-170//631aa//48%//Q99676
BRAWH20173790 [2015] BRAWH20174330//SPLICEOSOME ASSOCIATED PROTEIN
49 (SAP 49) (SF3B53).//4.50E-06//121aa//33%//Q15427 [2016]
BRAWH20175230 [2017] BRAWH20175340 [2018] BRAWH20176850//Mus
musculus mRNA for nuclear protein ZAP, complete
cds.//9.50E-151//619aa//53%//AB033168 [2019] BRAWH20182670 [2020]
BRAWH20183170//GRR1 PROTEIN.//9.30E-13//218aa//28%//P24814 [2021]
BRAWH20185260 [2022] BRAWH20185270 [2023] BRAWH20186010 [2024]
BRAWH20188750//BIOTIN SYNTHESIS PROTEIN
BIOC.//5.80E-11//190aa//27%//P36571 [2025] BRAWH20190530//Homo
sapiens BNPI mRNA for brain-specific Na-dependent inorganic
phosphate cotransporter, complete
cds.//2.10E-109//118aa//100%//AB032436 [2026]
BRAWH20190550//PUTATIVE SERINE/THREONINE-PROTEIN KINASE PKWA (EC
2.7.1.-).//1.30E-05//172aa//29%//P49695 [2027]
BRAWH20191980//PROLINE OXIDASE, MITOCHONDRIAL PRECURSOR (EC
1.5.3.-) (PROLINE DEHYDROGENASE).//2.10E-125//234aa//99%//043272
[2028] BRCAN10000760//UREA TRANSPORTER,
ERYTHROCYTE.//1.30E-212//389aa//100%//Q13336 [2029]
BRCAN10001050//PEANUT-LIKE PROTEIN 2 (BRAIN PROTEIN
H5).//1.40E-62//122aa//98%//043236 [2030] BRCAN10001680 [2031]
BRCAN20001480 [2032] BRCAN20004180//alpha-1C-adrenergic receptor
splice form 2--human//1.10E-22//76aa//76%//S65657 [2033]
BRCAN20005230//HEPARIN SULFATE N-DEACETYLASE/N-SULFOTRANSFERASE (EC
2.8.2.-) (N-HSST) (N-HEPARIN SULFATE SULFOTRANSFERASE)
(GLUCOSAMINYL
N-DEACETYLASE/N-SULFOTRANSFERASE).//8.90E-15//168aa//28%//P52849
[2034] BRCAN20005410//Human 1(3)mbt protein homolog mRNA, complete
cds.//2.00E-95//378aa//50%//U89358 [2035] BRCOC10000400 [2036]
BRCOC20000470//Homo sapiens DEME-6 mRNA, partial
cds.//7.30E-37//252aa//28%//AF007170 [2037] BRCOC20003600//VACUOLAR
ATP SYNTHASE SUBUNIT AC45 PRECURSOR (EC 3.6.1.34) (V-ATPASE AC45
SUBUNIT).//5.90E-192//418aa//85%//P40682 [2038] BRHIP10000720
[2039] BRHIP10001040//tweety homolog 1 (Drosophila) [Mus
musculus]//1.30E-68//311aa//44%//NP.sub.--067299 [2040]
BRHIP20000210 [2041] BRHIP20003590 [2042] BRHIP20005060 [2043]
BRSSN20001970 [2044] BRSSN20005610//Mus musculus semaphorin
cytoplasmic domain-associated protein 3A (Semcap3) mRNA, complete
cds.//6.30E-225//730aa//60%//AF127084 [2045] BRSSN20005660 [2046]
BRSSN20066440//ZINC FINGER PROTEIN
202.//3.60E-37//169aa//37%//095125 [2047]
BRSSN20074640//HYPOTHETICAL 35.8 KDA PROTEIN IN PRP16--SRP40
INTERGENIC REGION.//4.50E-20//217aa//28%//P36163 [2048]
BRSSN20091190 [2049] BRSSN20092440 [2050] BRSSN20093890//Homo
sapiens mRNA for Kelch motif containing protein, complete
cds.//8.40E-13//203aa//30%//AB026190 [2051] CD34C20001750//MHC
CLASS INK CELL RECEPTOR PRECURSOR (NATURAL KILLER ASSOCIATED
TRANSCRIPT 4) (NKAT-4).//1.10E-18//214aa//35%//P43630 [2052]
CTONG10000090 [2053] CTONG20000340 [2054] CTONG20002790 [2055]
CTONG20004110//Mus musculus ankycorbin mRNA, complete
cds.//6.20E-55//1006aa//24%//AF202315 [2056]
CTONG20004520//development- and differentiation-enhancing factor 2;
PYK2 C terminus-associated protein [Homo
sapiens].//2.00E-86//310aa//81%//NP.sub.--003878 [2057]
CTONG20007660//Rattus norvegicus caspase recruitment domain protein
9 mRNA, complete cds.//7.30E-28//319aa//32%//AF311288 [2058]
CTONG20008190//YPT1-RELATED PROTEIN
2.//3.00E-30//160aa//40%//P17609 [2059] CTONG20008460 [2060]
CTONG20015240 [2061] CTONG20017490//SEMAPHORIN 4A PRECURSOR
(SEMAPHORIN B) (SEMA B).//3.10E-273//607aa//82%//Q62178 [2062]
CTONG20020660 [2063] CTONG20020950//ZINC FINGER PROTEIN 37 (ZFP-37)
(MALE GERM CELL SPECIFIC ZINC FINGER
PROTEIN).//7.40E-23//258aa//25%//P17141 [2064] CTONG20027660 [2065]
CTONG20029030//Homo sapiens Ras-binding protein SUR-8 mRNA,
complete cds.//8.30E-25//402aa//28%//AF068920 [2066]
CTONG20030280//VEGETATIBLE INCOMPATIBILITY PROTEIN
HET-E-1.//2.90E-12//303aa//25%//Q00808 [2067] CTONG20031150 [2068]
CTONG20031890 [2069] CTONG20032930//microtubule associated-protein
orbit [Drosophila melanogaster]//1.00E-79//913aa//30%//BAA94248
[2070] CTONG20033500 [2071] CTONG20033610//Rattus norvegicus SNIP-a
mRNA, complete cds.//2.50E-145//567aa//41%//AF156981 [2072]
CTONG20033750//Drosophila melanogaster AAA family protein Bor (bor)
mRNA, complete cds.//1.40E-174//492aa//66%//AF227209 [2073]
CTONG20035240 [2074] CTONG20036800 [2075] CTONG20036990//BASEMENT
MEMBRANE-SPECIFIC HEPARAN SULFATE PROTEOGLYCAN CORE PROTEIN
PRECURSOR (HSPG) (PERLECAN) (PLC).//1.10E-10//247aa//27%//Q05793
[2076] CTONG20039370 [2077] CTONG20041150//Streptomyces
ansochromogenes strain 7100 SanE (sanE) gene, complete
cds.//5.20E-05//133aa//35%//AF228524 [2078] CTONG20041260//Mus
musculus retinoic acid-responsive protein (Stra6) mRNA, complete
cds.//1.30E-238//602aa//74%//AF062476 [2079]
CTONG20042640//NEUROBLAST DIFFERENTIATION ASSOCIATED PROTEIN AHNAK
(DESMOYOKIN) (FRAGMENTS).//0//797aa//73%//Q09666 [2080]
CTONG20044230//Mus musculus zinc finger protein (Mtsh1) mRNA,
partial cds.//1.40E-289//601aa//89%//AF191309 [2081] CTONG20044870
[2082] CTONG20045500//ANION EXCHANGE PROTEIN 3 (CARDIAC/BRAIN BAND
3-LIKE PROTEIN) (CAE3/BAE3).//2.00E-19//276aa//30%//P48751 [2083]
CTONG20046690 [2084] CTONG20049480 [2085] CTONG20050490 [2086]
CTONG20051100//PUTATIVE METHYLTRANSFERASE (EC
2.1.1.-).//3.50E-29//72aa//87%//043709 [2087] CTONG20051450//testis
development protein PRTD [Homo
sapiens].//9.00E-50//140aa//85%//AAG33852 [2088]
CTONG20052780//Homo sapiens mRNA for SH3 binding protein, complete
cds.//8.00E-21//125aa//42%//AB005047 [2089] CTONG20053990//ZINC
FINGER PROTEIN 195.//4.30E-08//40aa//75%//014628 [2090]
CTONG20055670 [2091] CTONG20055850//Rattus norvegicus golgi
peripheral membrane protein p65 (GRASP65) mRNA, complete
cds.//1.10E-99//248aa//78%//AF015264 [2092] CTONG20056150 [2093]
CTONG20057750 [2094] CTONG20057950 [2095] CTONG20059130//Mus
musculus prominin-like protein mRNA, partial
cds.//7.50E-103//259aa//77%//AF128113 [2096] CTONG20060040 [2097]
CTONG20061290 [2098] CTONG20062730 [2099] CTONG20063770//M-PHASE
PHOSPHOPROTEIN 9 (FRAGMENT).//1.80E-96//184aa//100%//Q99550 [2100]
CTONG20063930//BETA-CHIMAERIN
(BETA-CHIMERIN).//3.50E-31//189aa//34%//Q03070 [2101] CTONG20065240
[2102] CTONG20065680 [2103] CTONG20066110//Homo sapiens DEME-6
mRNA, partial cds.//8.70E-164//557aa//53%//AF007170 [2104]
CTONG20068360//MITOCHONDRIAL CARNITINE/ACYLCARNITINE CARRIER
PROTEIN (CARNITINE/ACYLCARNITINE TRANSLOCASE)
(CAC).//8.00E-30//248aa//35%//P97521 [2105] CTONG20069320 [2106]
CTONG20069420 [2107] CTONG20070090 [2108]
CTONG20070720//N-CHIMAERIN (NC) (N-CHIMERIN) (ALPHA CHIMERIN)
(A-CHIMAERIN).//9.20E-25//180aa//33%//P30337 [2109]
CTONG20070780//SPERM-SPECIFIC ANTIGEN 2 (CLEAVAGE SIGNAL-1 PROTEIN)
(CS-1).//1.90E-122//249aa//97%//P28290 [2110] CTONG20070910//Homo
sapiens mRNA for 26S proteasome subunit p55, complete
cds.//7.70E-227//400aa//100%//AB003103 [2111] CTONG20071040//BETA
CRYSTALLIN B2 (BP).//6.80E-25//195aa//34%//P26775 [2112]
CTONG20071680//HYPOTHETICAL 33.6 KDA PROTEIN IN TDK-PRFA INTERGENIC
REGION.//7.40E-14//328aa//23%//P45869 [2113] CTONG20072930//ZINC
FINGER PROTEIN 41 (FRAGMENT).//4.10E-216//542aa//69%//P51814 [2114]
CTONG20073990 [2115] CTONG20074000//Mus musculus teashirt 2 (Tsh2)
gene, partial cds.//0//1024aa//89%//AF207880 [2116] CTONG20074170
[2117] CTONG20074740 [2118] CTONG20076230 [2119]
CTONG20076810//site-1 protease of sterol regulatory element binding
proteins [Cricetulus griseus]//2.80E-245//463aa//93%//AF078105
[2120] CTONG20077760//SYNAPSIN I.//1.70E-08//209aa//32%//P17599
[2121] CTONG20078340//SUPPRESSOR PROTEIN
SRP40.//4.10E-08//282aa//26%//P32583 [2122]
CTONG20079590//ALPHA-N-ACETYLGALACTOSAMINIDE
ALPHA-2,6-SIALYLTRANSFERASE (EC 2.4.99.-) (ST6GALNACIII)
(STY).//1.80E-151//305aa//85%//Q64686 [2123]
CTONG20080140//HYPOTHETICAL 60.3 KDA PROTEIN R13G10.2 IN CHROMOSOME
III.//8.40E-29//179aa//40%//Q21988 [2124] CTONG20081840 [2125]
CTONG20083430 [2126] CTONG20083980//VASODILATOR-STIMULATED
PHOSPHOPROTEIN (VASP).//4.50E-10//113aa//34%//P50552 [2127]
CTONG20084020 [2128] CTONG20084660//ZINC FINGER PROTEIN
165.//3.30E-33//142aa//57%//P49910 [2129] CTONG20085210//MONO- AND
DIACYLGLYCEROL LIPASE PRECURSOR (EC 3.1.1.-)
(MDGL).//3.60E-06//94aa//34%//P25234 [2130] CTONG20133720 [2131]
CTONG20165590 [2132] CTONG20165750//SON PROTEIN
(SON3).//4.40E-239//427aa//99%//P18583 [2133] CTONG20166580 [2134]
CTONG20167750 [2135] CTONG20168240 [2136] CTONG20168460 [2137]
CTONG20169040//KERATIN, TYPE I CYTOSKELETAL 15 (CYTOKERATIN 15)
(K15) (CK 15).//6.00E-112//223aa//99%//P19012 [2138] CTONG20169530
[2139] CTONG20170940//MYOTROPHIN (V-1 PROTEIN) (GRANULE CELL
DIFFERENTIATION PROTEIN).//4.60E-10//93aa//36%//P80144 [2140]
CTONG20174290//TRICHOHYALIN.//1.30E-07//340aa//21%//P37709 [2141]
CTONG20174440 [2142] CTONG20174580//Homo sapiens mRNA for vascular
Rab-GAP/TBC-containing protein complete
cds.//1.00E-115//335aa//61%//NP.sub.--008994 [2143]
CTONG20176040//ADP-RIBOSYLATION FACTOR-LIKE PROTEIN 3
(ARD3).//1.70E-34//155aa//43%//P37996 [2144] CTONG20179390 [2145]
CTONG20179890 [2146] CTONG20179980 [2147] CTONG20180620 [2148]
CTONG20180690 [2149] CTONG20181350 [2150] CTONG20183430//ANKYRIN 2
(BRAIN ANKYRIN) (ANKYRIN B) (ANKYRIN,
NONERYTHROID).//4.60E-30//311aa//32%//Q01484 [2151]
CTONG20183830//IRLB [Homo
sapiens]//1.50E-104//191aa//100%//CAA45013 [2152] CTONG20184130
[2153] CTONG20184830//ATP-BINDING CASSETTE, SUB-FAMILY A, MEMBER 1
(ATP-BINDING CASSETTE TRANSPORTER 1) (ATP-BINDING CASSETTE
1).//1.30E-63//271aa//47%//P41233 [2154] CTONG20186140 [2155]
CTONG20186290//ALDEHYDE DEHYDROGENASE, DIMERIC NADP-PREFERRING (EC
1.2.1.5) (ALDH CLASS 3).//1.50E-74//144aa//100%//P30838 [2156]
CTONG20186370//ZINC FINGER PROTEIN 84 (ZINC FINGER PROTEIN
HPF2).//2.60E-52//324aa//33%//P51523 [2157] CTONG20186520//ZINC
FINGER PROTEIN MFG-3.//1.40E-197//643aa//53%//P16374 [2158]
CTONG20186550//cca3 protein--rat//2.10E-37//141aa//56%//T31081
[2159] CTONG20188080 [2160] CTONG20189000//PROBABLE GUANINE
NUCLEOTIDE REGULATORY PROTEIN TIM (ONCOGENE TIM) (P60 TIM)
(TRANSFORMING IMMORTALIZED MAMMARY
ONCOGENE).//1.10E-48//222aa//50%//Q12774 [2161] CTONG20190290//39.1
KDA PROTEIN IN SURE-CYSC INTERGENIC
REGION.//6.00E-15//132aa//31%//Q57261 [2162] CTONG20190630 [2163]
DFNES20016470//Homo sapiens SDP1 protein mRNA, complete
cds.//4.90E-33//95aa//37%//AF076957 [2164]
DFNES20018000//CADHERIN-RELATED TUMOR SUPPRESSOR PRECURSOR (FAT
PROTEIN).//8.70E-23//306aa//30%//P33450 [2165] DFNES20025500//Homo
sapiens mRNA for paraplegin-like
protein.//3.00E-29//68aa//94%//Y18314 [2166] DFNES20028170//Mouse
mRNA for RNA polymerase I associated factor (PAF53), complete
cds.//1.40E-165//393aa//78%//D14336 [2167] DFNES20029660 [2168]
DFNES20032550 [2169] DFNES20043710 [2170] DFNES20046840//FORKHEAD
BOX PROTEIN E1 (FORKHEAD-RELATED PROTEIN FKHL15) (THYROID
TRANSCRIPTION FACTOR 2) (TTF-2).//6.20E-05//151aa//32%//000358
[2171] DFNES20055400//Homo sapiens diphthamide biosynthesis
protein-2 (DPH2) mRNA, complete
cds.//5.40E-203//413aa//91%//AF053003 [2172] DFNES20057660//GRAVE'S
DISEASE CARRIER PROTEIN (GDC) (MITOCHONDRIAL SOLUTE CARRIER PROTEIN
HOMOLOG).//7.00E-31//247aa//33%//Q01888 [2173]
DFNES20063460//PAB-DEPENDENT POLY(A)-SPECIFIC RIBONUCLEASE SUBUNIT
PAN3 (EC 3.1.13.4) (PAB1P-DEPENDENT
POLY(A)-NUCLEASE).//1.90E-23//115aa//43%//P36102 [2174]
DFNES20072990//HYPOTHETICAL 46.7 KDA PROTEIN IN HOR7-COX7
INTERGENIC REGION.//1.80E-22//310aa//25%//Q04835 [2175]
DFNES20073320//Mus musculus RING-finger protein MURF mRNA, complete
cds.//6.70E-118//362aa//61%//AF294790 [2176] DFNES20076340 [2177]
DFNES20080880//POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE (EC
2.4.1.41) (PROTEIN-UDP ACETYLGALACTOSAMINYLTRANSFERASE)
(UDP-GALNAC:POLYPEPTIDE, N-ACETYLGALACTOSAMINYLTRANSFERASE)
(GALNAC-T1).//2.00E-104//486aa//43%//Q10472
[2178] DFNES20088810 [2179] DFNES20094820//coronin-like protein
[Schizosaccharomyces pombe]//3.60E-20//333aa//24%//CAB11184 [2180]
FCBBF10000230//H. sapiens mRNA from TYL
gene.//3.30E-155//650aa//51%//X99688 [2181] FCBBF10002200 [2182]
FCBBF10004760//Homo sapiens GAP-like protein (N61) mRNA, complete
cds.//9.10E-82//412aa//44%//AF251038 [2183]
FCBBF20018680//RABPHILIN-3A.//1.70E-16//262aa//30%//P47709 [2184]
FCBBF20020440 [2185] FCBBF20021110 [2186] FCBBF20023490//PUTATIVE
PRE-mRNA SPLICING FACTOR ATP-DEPENDENT RNA HELICASE
SPAC10F6.02C.//1.20E-90//505aa//39%//042643 [2187] FCBBF20028980
[2188] FCBBF20029280 [2189] FCBBF20032930 [2190]
FCBBF20033360//RING CANAL PROTEIN (KELCH
PROTEIN).//7.40E-33//234aa//32%//Q04652 [2191] FCBBF20035430//Mus
musculus arsenite inducible RNA associated protein (Airap) mRNA,
complete cds.//1.50E-51//152aa//57%//AF224494 [2192]
FCBBF20035490//GAP-associated tyrosine phosphoprotein p62 (Sam68)
[Homo sapiens]>pir.parallel.A38219 GAP-associated tyrosine
phosphoprotein p62//1.50E-214//415aa//93%//NP.sub.--006550 [2193]
FCBBF20036360 [2194] FCBBF20038230 [2195] FCBBF20038950 [2196]
FCBBF20041380 [2197] FCBBF20043730 [2198] FCBBF20054390 [2199]
FCBBF20056580//Mus musculus NSD1 protein mRNA, complete
cds.//3.40E-304//773aa//75%//AF064553 [2200] FCBBF20059660 [2201]
FCBBF20061310 [2202] FCBBF20066340//Homo sapiens nuclear
dual-specificity phosphatase (SBF1) mRNA, partial
cds.//1.20E-68//312aa//49%//U93181 [2203] FCBBF20070800 [2204]
FCBBF20070950//MICRONUCLEAR LINKER HISTONE POLYPROTEIN (MIC LH)
[CONTAINS: LINKER HISTONE PROTEINS ALPHA, BETA, DELTA AND
GAMMA].//5.00E-10//601aa//20%//P40631 [2205] FCBBF30000010 [2206]
FCBBF30001020 [2207] FCBBF30001100//CRAG protein [Drosophila
melanogaster]//7.40E-185//800aa//46%//CAA76938 [2208] FCBBF30001150
[2209] FCBBF30002270//HISTONE H1' (H1.0)
(H1(0)).//4.90E-62//154aa//84%//P07305 [2210]
FCBBF30002280//THIOREDOXIN PEROXIDASE 2 (THIOREDOXIN-DEPENDENT
PEROXIDE REDUCTASE 2) (PROLIFERATION-ASSOCIATED PROTEIN PAG)
(NATURAL KILLER CELL ENHANCING FACTOR A)
(NKEF-A).//1.20E-27//61aa//98%//Q06830 [2211] FCBBF30002330 [2212]
FCBBF30003610//ZINC FINGER PROTEIN 91 (ZINC FINGER PROTEIN HTF10)
(HPF7).//9.10E-93//313aa//53%//Q05481 [2213] FCBBF30004340//Homo
sapiens GalNAc-T9 mRNA for UDP-GalNAc:polypeptide
N-acetylgalactosaminyltransferase, complete
cds.//1.60E-109//299aa//63%//AB040672 [2214] FCBBF30004730 [2215]
FCBBF30005180 [2216] FCBBF30005360//Mus musculus spermatogenesis
associated factor (SPAF) mRNA, complete
cds.//0//894aa//84%//AF049099 [2217] FCBBF30005500//HYPOTHETICAL
PROTEIN KIAA0167.//5.80E-16//124aa//36%//Q99490 [2218]
FCBBF30019140//CHROMODOMAIN HELICASE-DNA-BINDING PROTEIN 3 (CHD-3)
(MI-2 AUTOANTIGEN 240 KDA PROTEIN)
(MI2-ALPHA).//0//725aa//82%//Q12873 [2219]
FCBBF30019180//SERINE/THREONINE PROTEIN PHOSPHATASE 2A, 65 KDA
REGULATORY SUBUNIT A, ALPHA ISOFORM (PP2A, SUBUNIT A, PR65-ALPHA
ISOFORM) (PP2A, SUBUNIT A, R1-ALPHA
ISOFORM).//4.60E-233//451aa//98%//P54612 [2220] FCBBF30019240
[2221] FCBBF30021900//ZINC FINGER PROTEIN 91 (ZINC FINGER PROTEIN
HTF10) (HPF7).//4.10E-161//633aa//48%//Q05481 [2222]
FCBBF30022680//putative 5'-3'
exonuclease//9.00E-12//200aa//25%//AAG29662 [2223]
FCBBF30026580//Homo sapiens retinoblastoma-associated protein
RAP140 mRNA, complete cds.//7.60E-27//367aa//28%//AF180425 [2224]
FCBBF30029250//GLUCOAMYLASE S1/S2 PRECURSOR (EC 3.2.1.3) (GLUCAN
1,4-ALPHA-GLUCOSIDASE) (1,4-ALPHA-D-GLUCAN
GLUCOHYDROLASE).//4.00E-18//754aa//23%//P08640 [2225] FCBBF30035570
[2226] FCBBF30042610//Homo sapiens CTL2
gene.//2.10E-137//393aa//60%//AJ245621 [2227] FCBBF30048420//TBX19
PROTEIN (T-BOX PROTEIN 19).//1.40E-94//212aa//85%//060806 [2228]
FCBBF30053300//Human autoantigen pericentriol material 1 (PCM-1)
mRNA, complete cds.//0//708aa//90%//L27841 [2229] FCBBF30056980
[2230] FCBBF30062490//Mus musculus prominin-like protein mRNA,
partial cds.//7.70E-85//210aa//79%//AF128113 [2231] FCBBF30063990
[2232] FCBBF30068210 [2233] FCBBF30071500//Homo sapiens dentin
phosphoryn mRNA, complete cds.//2.80E-09//675aa//22%//AF094508
[2234] FCBBF30072440//Homo sapiens SARDH mRNA, alternatively
spliced, complete cds.//1.70E-14//81aa//53%//AF095737 [2235]
FCBBF30072480 [2236] FCBBF30074530 [2237] FCBBF30074620 [2238]
FCBBF30075970 [2239] FCBBF30076310//CAMP-DEPENDENT PROTEIN KINASE,
BETA-CATALYTIC SUBUNIT (EC 2.7.1.37) (PKA
C-BETA).//8.20E-166//240aa//100%//P22694 [2240] FCBBF30078600
[2241] FCBBF30079770 [2242] FCBBF30080730//SPLICING FACTOR,
ARGININE/SERINE-RICH 7 (SPLICING FACTOR
9G8).//3.40E-70//136aa//95%//Q16629 [2243] FCBBF30081000 [2244]
FCBBF30085560//HYPOTHETICAL 60.3 KDA PROTEIN R13G10.2 IN CHROMOSOME
III.//1.10E-87//531aa//38%//Q21988 [2245] FCBBF30088700 [2246]
FCBBF30089380 [2247] FCBBF30091010 [2248]
FCBBF30091520//GLUCOAMYLASE S1/S2 PRECURSOR (EC 3.2.1.3) (GLUCAN
1,4-ALPHA-GLUCOSIDASE) (1,4-ALPHA-D-GLUCAN
GLUCOHYDROLASE).//3.70E-09//631aa//21%//P08640 [2249]
FCBBF30093170//ZINC FINGER PROTEIN 84 (ZINC FINGER PROTEIN
HPF2).//2.10E-63//173aa//65%//P51523 [2250] FCBBF30095410 [2251]
FCBBF30099490 [2252] FCBBF30100080//ARF NUCLEOTIDE-BINDING SITE
OPENER (ARNO PROTEIN) (ARF EXCHANGE
FACTOR).//1.10E-57//108aa//100%//Q99418 [2253] FCBBF30100120//Mus
musculus semaphorin cytoplasmic domain-associated protein 3A
(Semcap3) mRNA, complete cds.//2.10E-192//769aa//50%//AF127084
[2254] FCBBF30100410//Mus musculus testis-specific Y-encoded-like
protein (Tspyl1) mRNA, complete
cds.//1.90E-56//324aa//42%//AF042180 [2255] FCBBF30101240 [2256]
FCBBF30101300 [2257] FCBBF30105080 [2258] FCBBF30105440//Rattus
norvegicus ion transporter protein (NRITP) mRNA, partial
cds.//3.40E-36//82aa//91%//AF184921 [2259]
FCBBF30105860//microtubule associated-protein orbit [Drosophila
melanogaster].//1.00E-79//556aa//33%//BAA94248 [2260] FCBBF30106950
[2261] FCBBF30107290//MITOCHONDRIAL PROCESSING PEPTIDASE ALPHA
SUBUNIT PRECURSOR (EC 3.4.24.64) (ALPHA-MPP) (P-55) (HA1523)
(KIAA0123).//1.00E-91//172aa//100%//Q10713 [2262] FCBBF30107330
[2263] FCBBF30114180 [2264] FCBBF30114850//Homo sapiens C2H2
(Kruppel-type) zinc finger protein mRNA, complete
cds.//3.20E-24//249aa//34%//AF159567 [2265] FCBBF30115230 [2266]
FCBBF30115920//Homo sapiens nolp mRNA, complete
cds.//9.40E-220//257aa//100%//AB017800 [2267] FCBBF30118670//Homo
sapiens disintegrin and metalloproteinase domain 19 (ADAM19) mRNA,
partial cds.//0//601aa//97%//AF134707 [2268]
FCBBF30118890//Drosophila melanogaster La related protein (larp)
mRNA, partial cds.//6.70E-25//221aa//35%//AF221108 [2269]
FCBBF30125460 [2270] FCBBF30125880//Homo sapiens single-strand
selective monofunctional uracil DNA glycosylase mRNA, complete
cds.//6.40E-81//96aa//100%//AF125182 [2271] FCBBF30128420 [2272]
FCBBF30129010//ZINC FINGER PROTEIN 36 (ZINC FINGER PROTEIN KOX18)
(FRAGMENT).//1.20E-179//322aa//100%//P17029 [2273]
FCBBF30130410//CALDESMON (CDM).//3.30E-06//170aa//32%//P12957
[2274] FCBBF30130580 [2275] FCBBF30132050//Homo sapiens mRNA for
UDP-galactose:2-acetamido-2-deoxy-D-glucose3beta-galactosyltransferase.//-
2.10E-43//253aa//36%//Y15014 FCBBF30132660//Drosophila melanogaster
Canton S tartan protein (trn) mRNA, complete
cds.//2.00E-15//293aa//30%//U02078 [2276] FCBBF30135890//GLUTENIN,
LOW MOLECULAR WEIGHT SUBUNIT
PRECURSOR.//2.60E-07//163aa//34%//P10385 [2277]
FCBBF30136230//NIL-2-A ZINC FINGER PROTEIN (NEGATIVE REGULATOR OF
IL2) (TRANSCRIPTION FACTOR 8).//0//1090aa//94%//P37275 [2278]
FCBBF30138000//trg protein--rat//1.30E-82//560aa//37%//160486
[2279] FCBBF30142290//dJ127B20.3 (novel PHD finger protein) [Homo
sapiens].//1.00E-140//287aa//96%//CAB62994 [2280]
FCBBF30143550//FYVE FINGER-CONTAINING PHOSPHOINOSITIDE KINASE (EC
2.7.1.68) (1-PHOSPHATIDYLINOSITOL-4-PHOSPHATE KINASE) (PIP5K)
(PTDINS(4)P-5-KINASE) (P235).//0//1027aa//91%//Q9Z1T6 [2281]
FCBBF30145670 [2282] FCBBF30151190 [2283]
FCBBF30153170//6-PHOSPHOFRUCTOKINASE, LIVER TYPE (EC 2.7.1.11)
(PHOSPHOFRUCTOKINASE 1) (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTO-1-KINASE
ISOZYME B).//0//670aa//99%//P17858 [2284] FCBBF30157270//Rattus
norvegicus PAPIN mRNA, complete
cds.//1.20E-179//639aa//58%//AF169411 [2285] FCBBF30161780 [2286]
FCBBF30164510//RETINAL-CADHERIN PRECURSOR(R-CADHERIN)
(R-CAD).//0//794aa//98%//P55283 [2287] FCBBF30166220//SERINE
HYDROXYMETHYLTRANSFERASE, CYTOSOLIC (EC 2.1.2.1) (SERINE METHYLASE)
(GLYCINE HYDROXYMETHYLTRANSFERASE)
(SHMT).//2.70E-12//33aa//100%//P34896 [2288] FCBBF30169280//Petunia
x hybrida PGPD14 (PGPD14) mRNA, complete cds.//1.40E-62//261
aa//42%//AF049930 [2289] FCBBF30169870 [2290] FCBBF30170710 [2291]
FCBBF30171230//NEUROENDOCRINE CONVERTASE 2 PRECURSOR (EC 3.4.21.94)
(NEC 2) (PC2) (PROHORMONE CONVERTASE 2) (PROPROTEIN CONVERTASE 2)
(KEX2-LIKE ENDOPROTEASE 2).//1.70E-82//181aa//86%//P16519 [2292]
FCBBF30172330 [2293] FCBBF30173960//erythroid
differentiation-related factor 1 [Homo
sapiens].//6.00E-32//113aa//100%//AAC0001 [2294]
FCBBF30175350//MITOGEN-ACTIVATED PROTEIN KINASE 7 (EC 2.7.1.-)
(EXTRACELLULAR SIGNAL-REGULATED KINASE 5) (ERK5) (ERK4) (BMK1
KINASE).//4.60E-06//245aa//28%//Q13164 [2295]
FCBBF30177290//HYPOTHETICAL 47.6 KDA PROTEIN C16C10.5 IN CHROMOSOME
III.//2.40E-28//133aa//46%//Q09251 [2296] FCBBF30179180 [2297]
FCBBF30179740 [2298] FCBBF30181730 [2299] FCBBF30194370 [2300]
FCBBF30194550//ANKYRIN 1 (ERYTHROCYTE ANKYRIN) (ANKYRIN R)
(ANKYRINS 2.1 AND 2.2).//9.90E-54//478aa//33%//P16157 [2301]
FCBBF30195690//SYNAPTOTAGMIN I.//1.30E-27//138aa//31%//P34693
[2302] FCBBF30195700 [2303] FCBBF30197840//Mouse mRNA for
seizure-related gene product 6 type 2 precursor, complete
cds.//0//869aa//91%//D64009 [2304] FCBBF30198670//dof
protein--fruit fly (Drosophila
melanogaster)//6.60E-05//272aa//24%//T13712 [2305]
FCBBF30201630//Chlamydomonas reinhardtii dhc1 gene for 1-alpha
dynein heavy chain.//1.10E-121//384aa//58%//AJ243806 [2306]
FCBBF30212210 [2307] FCBBF30215240//mitogen inducible gene
mig-2--human//2.20E-135//263aa//96%//S69890 [2308]
FCBBF30220050//OXYSTEROLS RECEPTOR LXR-BETA (LIVER X RECEPTOR BETA)
(NUCLEAR ORPHAN RECEPTOR LXR-BETA) (UBIQUITOUSLY-EXPRESSED NUCLEAR
RECEPTOR) (NUCLEAR RECEPTOR NER).//6.90E-96//167aa//100%//P55055
[2309] FCBBF30222910//Mus musculus Rap2 interacting protein 8
(RPIP8) mRNA, complete cds.//4.70E-29//76aa//46%//U73941 [2310]
FCBBF30223110 [2311] FCBBF30223210//PLEXIN 4 PRECURSOR
(TRANSMEMBRANE PROTEIN SEX).//1.70E-72//179aa//76%//P51805 [2312]
FCBBF30225930 [2313] FCBBF30228940//Homo sapiens zinc finger
protein dp mRNA, complete cds.//2.60E-14//114aa//42%//AF153201
[2314] FCBBF30230610 [2315] FCBBF30236670//Homo sapiens DEAD-box
protein abstrakt (ABS) mRNA, complete
cds.//1.00E-128//276aa//91%//AF195417 [2316] FCBBF30250980//GUANINE
NUCLEOTIDE-BINDING PROTEIN BETA SUBUNIT-LIKE
PROTEIN.//3.20E-06//190aa//28%//024076 [2317] FCBBF30255680//Rattus
norvegicus brain specific cortactin-binding protein CBP90 mRNA,
partial cds.//1.80E-275//641aa//82%//AF053768 [2318]
FCBBF30257370//CARNITINE DEFICIENCY-ASSOCIATED PROTEIN EXPRESSED IN
VENTRICLE 1 (CDV-1 PROTEIN).//2.80E-169//355aa//92%//035594 [2319]
FCBBF30259050//Mus musculus (clone pMLZ-1) zinc finger protein
(Zfp) mRNA, 3' end of cds.//1.40E-241//499aa//83%//L36315 [2320]
FCBBF30260210//Drosophila melanogaster KISMET-L long isoform (kis)
mRNA, complete cds.//3.90E-178//420aa//68%//AF215703 [2321]
FCBBF30260480//Mus musculus putative E1-E2 ATPase mRNA, partial
cds.//1.80E-78//154aa//95%//AF156547 [2322] FCBBF30263080//ZINC
FINGER PROTEIN 83 (ZINC FINGER PROTEIN
HPF1).//4.20E-33//107aa//58%//P51522 FCBBF30266510 [2323]
FCBBF30271990//ANKYRIN 1 (ERYTHROCYTE
ANKYRIN).//3.00E-43//419aa//33%//Q02357 [2324]
FCBBF30275590//dedicator of cyto-kinesis 1 [Homo
sapiens].//1.00E-138//791aa//37%//NP.sub.--001371 [2325]
FCBBF30282020//cca3 protein--rat//5.50E-249//492aa//94%//T31081
[2326] FCBBF30285930//ZINC FINGER PROTEIN ZFP-1 (MKR1
PROTEIN).//5.70E-68//125aa//97%//P08042 [2327] FCBBF30287940 [2328]
FCBBF40000610//late gestation lung 2 protein [Rattus
norvegicus].//5.00E-86//178aa//94%//AAF44721 [2329] FCBBF40001920
[2330] FCBBF40005000 [2331] FCBBF50000410 [2332] FCBBF50000610
[2333] FCBBF50001650//Homo sapiens JP3 mRNA for junctophilin type3,
complete cds.//1.20E-111//407aa//57%//AB042636 [2334]
FCBBF50003530//H. sapiens mRNA for dinG
gene.//2.70E-137//181aa//100%//Y10571 [2335] FCBBF50004950 [2336]
FEBRA20005040//MYOSIN HEAVY CHAIN, STRIATED
MUSCLE.//1.90E-13//479aa//23%//P24733 [2337] FEBRA20007820//MLN 64
PROTEIN (CAB1 PROTEIN).//7.00E-31//129aa//51%//Q14849 [2338]
FEBRA20018670 [2339] FEBRA20026820//ZINC FINGER PROTEIN 91 (ZINC
FINGER PROTEIN HTF10) (HPF7).//2.20E-135//431aa//50%//Q05481 [2340]
FEBRA20027070//ZINC FINGER PROTEIN 41
(FRAGMENT).//1.00E-139//333aa//70%//P51814 [2341] FEBRA20029620
[2342] FEBRA20031000//TRICHOHYALIN.//2.20E-16//360aa//26%//P37709
[2343] FEBRA20031150//Homo sapiens HSKM-B (HSKM-B) mRNA, complete
cds.//2.00E-29//63aa//100%//AF226053 [2344] FEBRA20031280 [2345]
FEBRA20031810 [2346] FEBRA20035200 [2347]
FEBRA20035240//SPLICEOSOME ASSOCIATED PROTEIN 49 (SAP 49)
(SF3B53).//7.30E-05//108aa//31%//Q15427 [2348]
FEBRA20038220//GLUCOAMYLASE S1/S2 PRECURSOR (EC 3.2.1.3) (GLUCAN
1,4-ALPHA-GLUCOSIDASE) (1,4-ALPHA-D-GLUCAN
GLUCOHYDROLASE).//7.50E-05//256aa//24%//P08640 [2349] FEBRA20038330
[2350] FEBRA20038970//Homo sapiens mRNA for stabilin-1 (stab1
gene).//1.30E-42//413aa//99%//AJ275213 [2351] FEBRA20039070 [2352]
FEBRA20039260//NonF [Streptomyces griseus subsp.
griseus].//2.20E-16//140aa//38%//AAD37457 [2353] FEBRA20040230
[2354] FEBRA20040260 [2355] FEBRA20040290 [2356]
FEBRA20040560//Homo sapiens delta-6 fatty acid desaturase (CYB5RP)
mRNA, complete cds.//1.70E-112//204aa//100%//AF134404 [2357]
FEBRA20045380//EVI-5 homolog [Homo
sapiens].//7.00E-49//130aa//81%//AAC16031 [2358]
FEBRA20046200//ANKYRIN 2 (BRAIN ANKYRIN) (ANKYRIN B) (ANKYRIN,
NONERYTHROID).//1.70E-25//368aa//30%//Q01484 [2359] FEBRA20046280
[2360] FEBRA20046510//ZINC FINGER PROTEIN
135.//1.10E-94//260aa//62%//P52742 [2361] FEBRA20057010//ZINC
FINGER PROTEIN 195.//1.30E-12//47aa//70%//014628 [2362]
FEBRA20063720//ZINC FINGER PROTEIN 85 (ZINC FINGER PROTEIN HPF4)
(HTF1).//3.10E-243//586aa//73%//Q03923 [2363] FEBRA20076200 [2364]
FEBRA20078180 [2365] FEBRA20078800//NADH-UBIQUINONE OXIDOREDUCTASE
20 KDA SUBUNIT PRECURSOR (EC 1.6.5.3) (EC 1.6.99.3) (COMPLEX I-20
KD) (CI-20KD) (PSST SUBUNIT).//2.30E-96//192aa//96%//075251 [2366]
FEBRA20080860 [2367] FEBRA20082660 [2368] FEBRA20083410 [2369]
FEBRA20084750 [2370] FEBRA20086600 [2371]
FEBRA20087550//damage-specific DNA binding protein 2 (48 kD) [Homo
sapiens]//1.10E-106//119aa//94%//NP.sub.--000098 [2372]
FEBRA20088610//CELLULAR RETINALDEHYDE-BINDING PROTEIN
(CRALBP).//2.40E-14//145aa//30%//P10123
[2373] FEBRA20088810//FIBROBLAST GROWTH FACTOR-17 PRECURSOR
(FGF-17).//1.00E-102//193aa//99%//060258 [2374]
FEBRA20090160//MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 10
(EC 2.7.1.-) (MIXED LINEAGE KINASE 2) (PROTEIN KINASE
MST).//1.10E-15//111aa//48%//Q02779 [2375]
FEBRA20090220//TRANSLATION INITIATION FACTOR EIF-2B EPSILON SUBUNIT
(EIF-2B GDP-GTP EXCHANGE FACTOR).//0//721aa//90%//P47823 [2376]
FEBRA20091620 [2377] FEBRA20092760//PINCH PROTEIN (PARTICULARY
INTERESTING NEW CYS-HIS PROTEIN).//2.50E-81//165aa//80%//P48059
[2378] FEBRA20093270 [2379] FEBRA20093280 [2380] FEBRA20095410
[2381] FEBRA20098040 [2382] FEBRA20099860//dynactin 3 (p22);
dynactin light chain [Homo
sapiens]//1.70E-41//89aa//100%//NP.sub.--009165 [2383]
FEBRA20101410 [2384] FEBRA20108020 [2385] FEBRA20108580 [2386]
FEBRA20115930 [2387] FEBRA20116650 [2388] FEBRA20121200 [2389]
FEBRA20121950//X INACTIVE SPECIFIC TRANSCRIPT PROTEIN
(FRAGMENT).//1.60E-07//155aa//24%//P27571 [2390] FEBRA20141980
[2391] FEBRA20150420//HYPOTHETICAL 131.5 KDA PROTEIN CO.sub.2F12.7
IN CHROMOSOME X.//6.90E-56//877aa//24%//Q11102 [2392]
FEBRA20151750//Mus musculus (clone E5.53) Huntington disease (hdh)
gene, exon 5.//2.60E-12//88aa//43%//L34024 [2393] FEBRA20163980
[2394] FEBRA20170240//ZINC FINGER PROTEIN
75.//7.90E-158//278aa//99%//P51815 [2395] FEBRA20172230//Mus
musculus schwannoma-associated protein (SAM9) mRNA, complete
cds.//1.70E-57//295aa//40%//AF026124 [2396] FEBRA20173330//PROTEIN
KINASE CLK3 (EC 2.7.1.-).//4.80E-277//490aa//99%//P49761 [2397]
FEBRA20175020 [2398] FEBRA20175330 [2399] FEBRA20177800//RNA
binding motif protein 9 [Homo
sapiens].//4.00E-09//75aa//95%//NP.sub.--055124 [2400]
FEBRA20180510 [2401] FEBRA20182030 [2402] FEBRA20187460 [2403]
FEBRA20191720//REGULATOR OF G-PROTEIN SIGNALING 11
(RGS11).//2.00E-73//104aa//100%//094810 [2404]
HCHON10000150//SKELETAL MUSCLE LIM-PROTEIN 1 (SLIM 1) (SLIM) (FOUR
AND A HALF LIM DOMAINS PROTEIN 1)
(FHL-1).//4.10E-74//154aa//84%//Q13642 [2405] HCHON10001660 [2406]
HCHON20000870//SERINE/THREONINE-PROTEIN KINASE CTR1 (EC
2.7.1.37).//2.10E-21//300aa//26%//Q05609 [2407]
HCHON20002650//EARLY GROWTH RESPONSE PROTEIN 2 (EGR-2) (KROX-20
PROTEIN).//9.90E-05//166aa//26%//P51774 [2408]
HCHON20002710//UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 13 (EC
3.1.2.15) (UBIQUITIN THIOLESTERASE 13) (UBIQUITIN-SPECIFIC
PROCESSING PROTEASE 13) (DEUBIQUITINATING ENZYME
13).//7.40E-10//114aa//28%//P38187 [2409] HCHON20015050//LEUKOCYTE
ADHESION GLYCOPROTEIN P150, 95 ALPHA CHAIN PRECURSOR (LEUKOCYTE
ADHESION RECEPTOR P150, 95) (CD11C) (LEU M5) (INTEGRIN
ALPHA-X).//8.60E-06//250aa//26%//P20702 [2410] HEART10001420//Mus
musculus skm-BOP1 (Bop) mRNA, complete
cds.//6.10E-259//485aa//94%//U76373 [2411] HEART10001490//ACTIN
INTERACTING PROTEIN 2.//1.80E-71//243aa//58%//P46681 [2412]
HEART20009590//Homo sapiens mRNA for paraplegin-like
protein.//7.10E-47//145aa//67%//Y18314 [2413] HEART20019310//Mus
musculus RING-finger protein MURF mRNA, complete
cds.//6.70E-118//362aa//61%//AF294790 [2414]
HEART20022200//METHIONINE AMINOPEPTIDASE 2 (EC 3.4.11.18) (METAP 2)
(PEPTIDASE M 2) (INITIATION FACTOR 2 ASSOCIATED 67 KDA
GLYCOPROTEIN) (P67).//1.50E-209//447aa//86%//P50579 [2415]
HEART20031680 [2416] HEART20047640//CALCIUM/CALMODULIN-DEPENDENT
3',5'-CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 1C (EC 3.1.4.17) (CAM-PDE
1C).//0//769aa//94%//Q63421 [2417] HEART20063100//H. sapiens mRNA
histone RNA hairpin-binding
protein.//5.60E-114//212aa//100%//Z71188 [2418]
HEART20082570//AMINOMETHYLTRANSFERASE PRECURSOR (EC 2.1.2.10)
(GLYCINE CLEAVAGE SYSTEM T PROTEIN).//5.50E-113//210aa//69%//P28337
[2419] HHDPC10001140 [2420] HHDPC20051850//STEROID RECEPTOR PROTEIN
DG6.//9.50E-43//101aa//89%//015173 [2421] HHDPC20081230//NUCLEOLIN
(PROTEIN C23).//0//681aa//92%//P19338 [2422] HHDPC20082790 [2423]
HHDPC20082970 [2424] HHDPC20088160 [2425] HLUNG20008460//DIAPHANOUS
PROTEIN HOMOLOG 2.//7.60E-33//521aa//26%//060879 [2426]
HLUNG20009260 [2427] HLUNG20009550 [2428] HLUNG20010130 [2429]
HLUNG20011260//TYROSINE-PROTEIN KINASE SRC-1 (EC 2.7.1.112)
(P60-SRC-1).//1.10E-46//92aa//100%//P13115 [2430] HLUNG20011440
[2431] HLUNG20011460//Rattus norvegicus serine-arginine-rich
splicing regulatory protein SRRP86 mRNA, complete
cds.//1.20E-159//398aa//79%//AF234765 [2432] HLUNG20012140 [2433]
HLUNG20014590//ZINC FINGER PROTEIN
135.//1.20E-122//350aa//59%//P52742 [2434] HLUNG20015070//SLIT
PROTEIN PRECURSOR.//5.00E-14//167aa//33%//P24014 [2435]
HLUNG20015180//BALBIANI RING PROTEIN 3
PRECURSOR.//8.80E-08//444aa//24%//Q03376 [2436] HLUNG20020500
[2437] HLUNG20020850//TLM PROTEIN (TLM
ONCOGENE).//5.00E-17//91aa//54%//P17408 [2438] HLUNG20021450 [2439]
HLUNG20023030 [2440] HLUNG20024050 [2441] HLUNG20025620 [2442]
HLUNG20028110//zinc finger protein--fission yeast
(Schizosaccharomyces pombe).//2.70E-23//140aa//38%//T39456 [2443]
HLUNG20029420 [2444] HLUNG20029490 [2445] HLUNG20030420//Mus
musculus mRNA for MAIL, complete
cds.//1.00E-164//728aa//68%//AB020974 [2446]
HLUNG20030490//Ambystoma tigrinum RPE65 protein mRNA, complete
cds.//1.70E-64//335aa//42%//AF047465 [2447] HLUNG20030610 [2448]
HLUNG20031620 [2449] HLUNG20032460//LYSOSOMAL PRO-X
CARBOXYPEPTIDASE PRECURSOR (EC 3.4.16.2) (PROLYLCARBOXYPEPTIDASE)
(PRCP) (PROLINE CARBOXYPEPTIDASE) (ANGIOTENSINASE C) (LYSOSOMAL
CARBOXYPEPTIDASE C).//8.60E-274//440aa//99%//P42785 [2450]
HLUNG20033060//Homo sapiens GAP-like protein (N61) mRNA, complete
cds.//1.20E-81//389aa//45%//AF251038 [2451] HLUNG20033310 [2452]
HLUNG20033350 [2453] HLUNG20034970 [2454] HLUNG20037140 [2455]
HLUNG20037160//RETROVIRUS-RELATED ENV
POLYPROTEIN.//1.90E-131//439aa//54%//P10267 [2456] HLUNG20037780
[2457] HLUNG20038330 [2458] HLUNG20041540//GLUCOAMYLASE S1/S2
PRECURSOR (EC 3.2.1.3) (GLUCAN 1,4-ALPHA-GLUCOSIDASE)
(1,4-ALPHA-D-GLUCAN GLUCOHYDROLASE).//8.80E-08//286aa//24%//P08640
[2459] HLUNG20041590//ubiquitous tetratricopeptide containing
protein RoXaN [Homo sapiens].//1.00E-158//737aa//42%//AAF05541
[2460] HLUNG20042730//CYTOCHROME P450 4A4 (EC 1.14.14.1) (CYPIVA4)
(PROSTAGLANDIN OMEGA-HYDROXYLASE)
(P450-P-2).//4.90E-126//442aa//49%//P10611 [2461]
HLUNG20045340//MOB2 PROTEIN (MPS1 BINDER
2).//4.60E-27//135aa//37%//P43563 [2462] HLUNG20047070 [2463]
HLUNG20050760 [2464] HLUNG20051330 [2465] HLUNG20052300//AIG1
PROTEIN.//3.00E-23//216aa//30%//P54120 [2466]
HLUNG20054790//PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT (EC
2.7.1.137) (IB PI3-KINASE P101 SUBUNIT) (PTDINS-3-KINASE P101)
(PI3K) (P101-P13K).//8.30E-22//292aa//25%//002696 [2467]
HLUNG20055240 [2468] HLUNG20056560 [2469] HLUNG20057380 [2470]
HLUNG20059240 [2471] HLUNG20060670 [2472] HLUNG20063700//H. sapiens
PEBP2aC1 acute myeloid leukaemia mRNA.//3.60E-22//62aa//79%//Z35278
[2473] HLUNG20065700 [2474] HLUNG20065990//SYNTAXIN
4.//8.80E-127//267aa//96%//Q12846 [2475] HLUNG20067810 [2476]
HLUNG20068120//NUCLEAR TRANSITION PROTEIN 2
(TP-2).//7.10E-06//86aa//38%//P11101 [2477]
HLUNG20069350//CALCYPHOSINE.//1.80E-13//128aa//31%//Q13938 [2478]
HLUNG20070410 [2479] HLUNG20072100//Gallus gallus Dach2 protein
(Dach2) mRNA, complete cds.//1.40E-236//404aa//79%//AF198349 [2480]
HLUNG20072190 [2481] HLUNG20072450 [2482] HLUNG20074330 [2483]
HLUNG20079310 [2484] HLUNG20081390//DNAJ
PROTEIN.//1.60E-17//98aa//47%//P35515 [2485]
HLUNG20081530//NEUROFILAMENT TRIPLET H PROTEIN (200 KDA
NEUROFILAMENT PROTEIN) (NF-H).//1.90E-09//220aa//25%//P12036 [2486]
HLUNG20082350//Homo sapiens goodpasture antigen-binding protein
(COL4A3BP) mRNA, complete cds.//0//399aa//93%//AF136450 [2487]
HLUNG20083330//alpha1 (III) collagen [Homo
sapiens]//5.40E-61//113aa//99%//CAA29886 [2488]
HLUNG20083480//Chicken mRNA for TSC-22 variant, complete cds, clone
SLFEST52.//9.00E-178//527aa//68%//D82364 [2489] HLUNG20083840
[2490] HLUNG20083960 [2491] HLUNG20084790//HYPOTHETICAL 65.2 KDA
TRP-ASP REPEATS CONTAINING PROTEIN D2030.9 IN CHROMOSOME
I.//5.50E-47//161aa//53%//P90794 [2492] HLUNG20085210//Homo sapiens
intersectin 2 (SH3D1B) mRNA, complete
cds.//9.60E-28//62aa//95%//AF248540 [2493] HLUNG20088750 [2494]
HLUNG20092530 [2495] HLUNG20093030 [2496] HLUNG20094130 [2497]
KIDNE20011600 [2498] KIDNE20016360//Rattus norvegicus potassium
channel (erg2) mRNA, complete cds.//0//418aa//96%//AF016192 [2499]
KIDNE20024380 [2500] KIDNE20027980 [2501] KIDNE20080690//PROBABLE
AMINOTRANSFERASE T01B11.2 (EC
2.6.1.-).//5.80E-114//445aa//48%//P91408 [2502] KIDNE20081170//Homo
sapiens microtubule-based motor (HsKIFC3) mRNA, complete
cds.//6.20E-153//216aa//99%//AF004426 [2503] KIDNE20083150 [2504]
KIDNE20083620//L-ASPARAGINASE (EC 3.5.1.1) (L-ASPARAGINE
AMIDOHYDROLASE).//2.60E-53//148aa//43%//Q9ZSD6 [2505] KIDNE20084030
[2506] KIDNE20084040//PHOSPHOLIPASE D1 (EC 3.1.4.4) (PLD 1)
(CHOLINE PHOSPHATASE 1) (PHOSPHATIDYLCHOLINE-HYDROLYZING
PHOSPHOLIPASE D1).//3.30E-70//134aa//100%//Q13393 [2507]
KIDNE20084730//Homo sapiens FH1/FH2 domain-containing protein FHOS
(FHOS) mRNA, complete cds.//2.60E-148//599aa//52%//AF113615 [2508]
KIDNE20084800 [2509] KIDNE20086490 [2510] KIDNE20086660 [2511]
KIDNE20086970 [2512] KIDNE20087880 [2513] KIDNE20088240//atopy
related autoantigen CALC [Homo
sapiens].//1.00E-26//300aa//26%//CAA76830 [2514]
KIDNE20089870//HISTONE ACETYLTRANSFERASE TYPE B SUBUNIT 2
(RETINOBLASTOMA BINDING PROTEIN P46) (RETINOBLASTOMA-BINDING
PROTEIN 7).//4.30E-237//422aa//99%//Q16576 [2515] KIDNE20091090
[2516] KIDNE20094260 [2517] KIDNE20094670//Drosophila melanogaster
AAA family protein Bor (bor) mRNA, complete
cds.//2.10E-124//399aa//59%//AF227209 [2518] KIDNE20095530 [2519]
KIDNE20133460//Homo sapiens mRNA for sperm
protein.//3.40E-146//284aa//100%//X91879 [2520] KIDNE20133880
[2521] KIDNE20134130 [2522] KIDNE20134890//CENTROMERIC PROTEIN E
(CENP-E PROTEIN).//7.70E-05//169aa//21%//Q02224 [2523]
KIDNE20137310 [2524] KIDNE20138450 [2525] KIDNE20140870//zinc
finger protein 106 [Mus musculus]//2.10E-288//822aa//67%//AF060246
[2526] KIDNE20141120 [2527] KIDNE20141700//40S RIBOSOMAL PROTEIN
S4, X ISOFORM (SINGLE COPY ABUNDANT mRNA PROTEIN)
(SCR10).//2.60E-72//153aa//89%//P12750 [2528] KIDNE20142680 [2529]
KIDNE20142900//THROMBOMODULIN PRECURSOR (FETOMODULIN) (TM) (CD141
ANTIGEN).//1.80E-71//119aa//100%//P07204 [2530] KIDNE20143200
[2531] KIDNE20147170//acetylglutamate synthase--fission yeast
(Schizosaccharomyces pombe)//8.40E-15//143aa//37%//T40666 [2532]
KIDNE20148080 [2533] KIDNE20149780//NG28 [Mus
musculus]//3.50E-66//367aa//44%//AAC97966 [2534]
KIDNE20150730//REGULATOR OF MITOTIC SPINDLE ASSEMBLY 1
(RMSA-1).//2.40E-06//84aa//41%//P49646 [2535] KIDNE20152440//Homo
sapiens mRNA for serin protease with IGF-binding motif, complete
cds.//1.80E-181//388aa//93%//D87258 [2536] KIDNE20154330//Rattus
norvegicus mRNA for multi PDZ domain
protein.//0//763aa//87%//AJ001320 [2537] KIDNE20154830 [2538]
KIDNE20155980 [2539] KIDNE20157100 [2540] KIDNE20160360//ARF
NUCLEOTIDE-BINDING SITE OPENER (ARNO PROTEIN) (ARF EXCHANGE
FACTOR).//7.10E-40//194aa//41%//Q99418 [2541] KIDNE20160960 [2542]
KIDNE20163710 [2543] KIDNE20165390//Homo sapiens mRNA for
beta-tubulin folding cofactor D.//0//709aa//94%//AJ006417 [2544]
KIDNE20169180//UROMODULIN PRECURSOR (TAMM-HORSFALL URINARY
GLYCOPROTEIN) (THP).//0//615aa//99%//P07911 [2545] KIDNE20170400
[2546] KIDNE20173150//Bos taurus mRNA for mitochondrial aralkyl
acylCoA:amino acid
N-acyltransferase.//2.90E-53//277aa//40%//AJ223301 [2547]
KIDNE20173430//Homo sapiens PDZ domain containing-protein (PDZK1)
mRNA, complete cds.//7.90E-28//150aa//34%//AF012281 [2548]
KIDNE20176030 [2549] KIDNE20181670 [2550] KIDNE20182540 [2551]
KIDNE20186170//UDP-GLUCURONOSYLTRANSFERASE 2B13 PRECURSOR,
MICROSOMAL (EC 2.4.1.17) (UDPGT)
(EGT10).//4.40E-38//214aa//39%//P36512 [2552] KIDNE20188630 [2553]
KIDNE20189890//Homo sapiens mRNA for KARP-1-binding protein 2
(KAB2), complete cds.//6.00E-30//177aa//44%//AB022658 [2554]
KIDNE20189960//TREHALASE PRECURSOR (EC 3.2.1.28)
(ALPHA,ALPHA-TREHALASE) (ALPHA,ALPHA-TREHALOSE
GLUCOHYDROLASE).//1.40E-224//421aa//97%//043280 [2555]
KIDNE20191870 [2556] LIVER20006260//Mus musculus zinc finger
protein ZFP113 mRNA, complete cds.//4.50E-183//385aa//85%//AF167320
[2557] LIVER20007690 [2558] LIVER20007750 [2559] LIVER20010510
[2560] LIVER20010760//Homo sapiens C-type lectin-like receptor-1
mRNA, complete cds.//3.10E-134//208aa//100%//AF200949 [2561]
LIVER20010990//Rattus norvegicus mRNA for putative integral
membrane transport protein (UST1r).//7.00E-52//196aa//54%//Y09945
[2562] LIVER20011640//Human proline rich calmodulin-dependent
protein kinase mRNA, complete cds.//2.00E-116//221aa//97%//U23460
[2563] LIVER20013890 [2564] LIVER20026440//CYTOCHROME P450 4F3 (EC
1.14.13.30) (CYPIVF3) (LEUKOTRIENE-B4 OMEGA-HYDROXYLASE)
(LEUKOTRIENE-B4 20-MONOOXYGENASE) (CYTOCHROME
P450-LTB-OMEGA).//2.60E-136//295aa//84%//Q08477 [2565]
LIVER20030650//WHITE PROTEIN.//7.20E-09//229aa//25%//Q05360 [2566]
LIVER20032340 [2567] LIVER20038000//MITOCHONDRIAL
CARNITINE/ACYLCARNITINE CARRIER PROTEIN (CARNITINE/ACYLCARNITINE
TRANSLOCASE) (CAC).//9.40E-40//148aa//38%//P97521 [2568]
LIVER20040740//RETINAL-BINDING PROTEIN
(RALBP).//3.10E-60//337aa//37%//P49193 [2569]
LIVER20055270//SELENIDE, WATER DIKINASE 2 (EC 2.7.9.3)
(SELENOPHOSPHATE SYNTHETASE 2) (SELENIUM DONOR PROTEIN
2).//2.70E-204//376aa//97%//Q99611 [2570] MESAN20006200//ANNEXIN II
(LIPOCORTIN II) (CALPACTIN I HEAVY CHAIN) (CHROMOBINDIN 8) (P36)
(PROTEIN I) (PLACENTAL ANTICOAGULANT PROTEIN IV)
(PAP-IV).//1.70E-84//174aa//95%//P07355 [2571] MESAN20007110 [2572]
MESAN20008150 [2573] MESAN20008940 [2574] MESAN20009090//Homo
sapiens CEGP1 protein (CEGP1),
mRNA//1.10E-179//553aa//58%//NM.sub.--020974 [2575]
MESAN20016270//ZINC FINGER PROTEIN 37A (ZINC FINGER PROTEIN KOX21)
(FRAGMENT).//1.60E-141//242aa//100%//P17032 [2576]
MESAN20021130//Human SH3 domain-containing proline-rich kinase
(sprk) mRNA, complete cds.//8.20E-168//346aa//91%//U07747
MESAN20021220//INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN COMPLEX
ACID LABILE CHAIN PRECURSOR (ALS).//7.40E-26//197aa//30%//002833
[2577] MESAN20021470//SPINDLIN (30000 MR METAPHASE COMPLEX) (SSEC
P).//3.50E-123//229aa//98%//Q61142 [2578] MESAN20021860 [2579]
MESAN20026870 [2580] MESAN20027240//Rho guanine nucleotide exchange
factor (GEF) 10 [Homo
sapiens].//1.00E-134//620aa//40%//NP.sub.--055444 [2581]
MESAN20027900//COLLAGEN ALPHA 3(VI) CHAIN
PRECURSOR//0//1001aa//98%//P12111 [2582] MESAN20029780 [2583]
MESAN20030350//Mus musculus diaphanous-related formin (Dia2) mRNA,
complete cds.//6.60E-301//669aa//84%//AF094519 [2584] MESAN20030370
[2585] MESAN20030390 [2586] MESAN20033220//ALDEHYDE DEHYDROGENASE 7
(EC 1.2.1.5).//1.60E-24//54aa//100%//P43353 [2587]
MESAN20034440//39.1 KDA PROTEIN IN SURE-CYSC INTERGENIC
REGION.//2.70E-07//117aa//31%//Q57261
[2588] MESAN20038520//DNA-DIRECTED RNA POLYMERASE III 128 KDA
POLYPEPTIDE (EC 2.7.7.6) (RNA POLYMERASE III SUBUNIT
2).//0//831aa//70%//P25167 [2589] MESAN20041380 [2590]
MESAN20045750 [2591] MESAN20056890//SPLICING FACTOR,
ARGININE/SERINE-RICH 2 (SPLICING FACTOR SC35) (SC-35) (SPLICING
COMPONENT, 35 KDA) (PR264 PROTEIN).//3.30E-12//97aa//48%//Q01130
[2592] MESAN20057240//DNA EXCISION REPAIR PROTEIN
ERCC-1.//5.90E-120//195aa//98%//P07992 [2593] MESAN20058110//65 KDA
FK506-BINDING PROTEIN PRECURSOR (EC 5.2.1.8) (FKBP65) (FKBPRP)
(PEPTIDYL-PROLYL CIS-TRANS ISOMERASE) (PPIASE) (ROTAMASE)
(IMMUNOPHILIN FKBP65).//8.00E-117//229aa//89%//Q61576 [2594]
MESAN20059570//Rattus norvegicus mRNA for seven transmembrane
receptor, complete cds.//1.00E-173//484aa//63%//BAA82518 [2595]
MESAN20060220 [2596] MESAN20060430 [2597] MESAN20065990//Human
protein serine/threonine kinase stk2 mRNA, complete
cds.//2.40E-07//65aa//50%//L20321 [2598]
MESAN20067430//TROPOMYOSIN, FIBROBLAST ISOFORM
TM3.//1.80E-39//87aa//100%//P09494 [2599] MESAN20069530//LIM domain
only 7 isoform c [Homo
sapiens]//2.20E-286//545aa//99%//NP.sub.--056667 [2600]
MESAN20084150//Mus musculus secretory carrier membrane protein 4
mRNA, complete cds.//2.20E-48//128aa//72%//AF224721 [2601]
MESAN20085360 [2602] MESAN20089260 [2603] MESAN20090190//CEGP1
protein [Homo sapiens].//0//880aa//57%//NP.sub.--066025 [2604]
MESAN20094180 [2605] MESAN20095220 [2606]
MESAN20095800//PEPTIDYL-PROLYL CIS-TRANS ISOMERASE 10 (EC 5.2.1.8)
(PPIASE) (ROTAMASE) (CYCLOPHILIN-10).//1.60E-31//150aa//46%//P52017
[2607] NESOP20004520//LYMPHOCYTE-SPECIFIC PROTEIN LSP1 (PP52
PROTEIN) (52 KDA PHOSPHOPROTEIN) (LYMPHOCYTE-SPECIFIC ANTIGEN
WP34).//3.40E-173//321aa//99%//P33241 [2608] NESOP20005040 [2609]
NT2NE20018740 [2610] NT2NE20018890//Homo sapiens WD-repeat protein
6 (WDR6) mRNA, complete cds.//6.60E-184//257aa//99%//AF099100
[2611] NT2NE20021860//Lytechinus variegatus embryonic blastocoelar
extracellular matrix protein precursor (ECM3) mRNA, complete
cds.//9.00E-68//466aa//36%//AF287478 [2612]
NT2NE20026200//TRANSKETOLASE (EC 2.2.1.1)
(TK).//1.80E-160//310aa//99%//P29401 [2613] NT2NE20026510//basic
protein, cytosolic--fruit fly (Drosophila
melanogaster)//6.10E-35//202aa//41%//S47857 [2614] NT2NE20028700
[2615] NT2NE20033150 [2616] NT2NE20037050//U2 SMALL NUCLEAR
RIBONUCLEOPROTEIN AUXILIARY FACTOR 35 KDA SUBUNIT RELATED-PROTEIN
2.//7.20E-08//109aa//38%//Q15696 [2617] NT2NE20038870//ZINC FINGER
X-LINKED PROTEIN ZXDA (FRAGMENT).//5.90E-153//405aa//72%//P98168
[2618] NT2NE20039210 [2619] NT2NE20042550//ADENYLATE KINASE,
CHLOROPLAST (EC 2.7.4.3) (ATP-AMP
TRANSPHOSPHORYLASE).//7.80E-15//153aa//28%//P43188 [2620]
NT2NE20045190 [2621] NT2NE20047870 [2622] NT2NE20053230 [2623]
NT2NE20053950//ZINC FINGER PROTEIN
136.//6.40E-108//284aa//64%//P52737 [2624] NT2NE20059210 [2625]
NT2NE20059680//Homo sapiens integrin cytoplasmic domain associated
protein (Icap-1a) mRNA, complete
cds.//1.80E-44//96aa//100%//AF012023 [2626] NT2NE20060750//ZINC
FINGER PROTEIN ZFP-36 (FRAGMENT).//1.20E-69//198aa//68%//P16415
[2627] NT2NE20061030//ZINC FINGER PROTEIN
165.//3.00E-39//125aa//65%//P49910 [2628] NT2NE20062880 [2629]
NT2NE20064780//A-AGGLUTININ ATTACHMENT SUBUNIT
PRECURSOR.//4.10E-05//443aa//24%//P32323 [2630] NT2NE20066590
[2631] NT2NE20069580 [2632] NT2NE20070520 [2633] NT2NE20073650
[2634] NT2NE20077250//Homo sapiens cell cycle progression 2 protein
(CPR2) mRNA, complete cds.//1.20E-173//349aa//94%//AF011792 [2635]
NT2NE20077270 [2636] NT2NE20077860 [2637] NT2NE20079670//ZINC
FINGER PROTEIN 84 (ZINC FINGER PROTEIN
HPF2).//2.60E-98//345aa//47%//P51523 [2638] NT2NE20080770 [2639]
NT2NE20082130 [2640] NT2NE20082600//Homo sapiens zinc finger
protein dp mRNA, complete cds.//2.10E-19//163aa//42%//AF153201
[2641] NT2NE20086070 [2642] NT2NE20087270//Homo sapiens putative
RNA binding protein mRNA, alternatively spliced, complete
cds.//4.30E-14//221aa//29%//AF119121 [2643]
NT2NE20087850//ANTER-SPECIFIC PROLINE-RICH PROTEIN APG (PROTEIN
CEX) (FRAGMENT).//1.80E-08//75aa//40%//P40603 [2644] NT2NE20088030
[2645] NT2NE20092950 [2646] NT2NE20095230//Homo sapiens HSKM-B
(HSKM-B) mRNA, complete cds.//1.40E-09//112aa//32%//AF226053 [2647]
NT2NE20104000 [2648] NT2NE20107810 [2649] NT2NE20108420//KES1
PROTEIN.//4.70E-25//312aa//31%//P35844 [2650]
NT2NE20111190//C-TERMINAL BINDING PROTEIN
2.//9.00E-54//137aa//84%//P56545 [2651] NT2NE20112210 [2652]
NT2NE20114850 [2653] NT2NE20117580//NADH-UBIQUINONE OXIDOREDUCTASE
20 KDA SUBUNIT PRECURSOR (EC 1.6.5.3) (EC 1.6.99.3) (COMPLEX I-20
KD) (CI-20 KD) (PSST SUBUNIT).//1.20E-76//153aa//95%//075251 [2654]
NT2NE20119980//TUMOR NECROSIS FACTOR, ALPHA-INDUCED PROTEIN 1,
ENDOTHELIAL (B12 PROTEIN).//6.10E-48//135aa//74%//Q13829 [2655]
NT2NE20123610 [2656] NT2NE20124570 [2657] NT2NE20126030 [2658]
NT2NE20127900//Homo sapiens myo-inositol 1-phosphate synthase A1
(ISYNA1) mRNA, complete cds.//1.40E-269//465aa//99%//AF220530
[2659] NT2NE20140130//SEMAPHORIN 3B PRECURSOR (SEMAPHORIN V) (SEMA
V).//1.90E-42//90aa//100%//Q13214 [2660] NT2NE20140280 [2661]
NT2NE20141040//DOWN SYNDROME CRITICAL REGION PROTEIN
1.//1.80E-105//197aa//99%//P53805 [2662] NT2NE20145250//SCG10
PROTEIN (SUPERIOR CERVICAL GANGLION-10
PROTEIN).//2.50E-58//141aa//88%//P55821 [2663]
NT2NE20146510//HYPOTHETICAL 104.7 KDA PROTEIN F23F12.8 IN
CHROMOSOME III PRECURSOR.//6.20E-08//179aa//23%//P46504 [2664]
NT2NE20148690 [2665] NT2NE20149500 [2666] NT2NE20150610 [2667]
NT2NE20152620 [2668] NT2NE20153620//mitogen inducible gene
mig-2--human//7.90E-147//449aa//63%//S69890 [2669]
NT2NE20155650//RETROVIRUS-RELATED ENV
POLYPROTEIN.//2.30E-29//114aa//33%//P10267 [2670] NT2NE20157120
[2671] NT2NE20165190 [2672] NT2NE20167660//Mus musculus nuclear
localization signal binding protein (spot-1) mRNA, complete
cds.//3.50E-09//76aa//40%//S79410 [2673] NT2NE20173970//Rattus
norvegicus beta-catenin binding protein mRNA, complete
cds.//1.60E-24//134aa//46%//AF169825 [2674]
NT2NE20177210//Leishmania major partial ppg1 gene for
proteophosphoglycan.//1.10E-06//169aa//27%//AJ243460 [2675]
NT2NE20181760 [2676] NT2NE20181800 [2677] NT2NE20184720 [2678]
NT2RI20016240 [2679] NT2RI20021200 [2680] NT2RI20033920 [2681]
NT2RI20093010//BIFUNCTIONAL METHYLENETETRAHYDROFOLATE
DEHYDROGENASE/CYCLOHYDROLASE, MITOCHONDRIAL PRECURSOR [INCLUDES:
NAD-DEPENDENT METHYLENETETRAHYDROFOLATE DEHYDROGENASE (EC
1.5.1.15); METHENYLTETRAHYDROFOLATE CYCLOHYDROLASE (EC
3.5.4.9)].//5.90E-34//86aa//81%//P13995 [2682] NT2RP70001120//GA
BINDING PROTEIN BETA-1 CHAIN (GABP-BETA-1 SUBUNIT)
(GABPB1).//2.50E-113//384aa//62%//Q00420 [2683] NT2RP70001730//Mus
musculus actin-binding protein (ENC-1) mRNA, complete
cds.//4.30E-249//589aa//74%//U65079 [2684] NT2RP70003110//ELASTIN
PRECURSOR (TROPOELASTIN).//1.40E-165//613aa//61%//P15502 [2685]
NT2RP70012830//CALPHOTIN.//7.90E-17//445aa//28%//Q02910 [2686]
NT2RP70022820 [2687] NT2RP70027190//RAS SUPPRESSOR PROTEIN 1
(RSU-1) (RSP-1 PROTEIN) (RSP-1).//3.80E-23//186aa//34%//Q01730
[2688] NT2RP70029780//ZINC FINGER PROTEIN ZFP-36
(FRAGMENT).//4.30E-118//381aa//56%//P16415 [2689]
NT2RP70030840//Mus musculus schlafen3 (Slfn3) mRNA, complete
cds.//3.70E-55//328aa//33%//AF099974 [2690] NT2RP70031070//36 KDA
NUCLEOLAR PROTEIN HNP36 (DELAYED-EARLY RESPONSE PROTEIN 12)
(DER12).//1.20E-23//169aa//34%//Q61672 [2691] NT2RP70031340 [2692]
NT2RP70031480 [2693] NT2RP70035110//Caenorhabditis elegans UNC-89
(unc-89) gene, complete cds.//1.50E-07//229aa//26%//U33058 [2694]
NT2RP70046410//BASONUCLIN.//3.60E-71//318aa//43%//Q01954 [2695]
NT2RP70049610 [2696] NT2RP70056290 [2697] NT2RP70056690//F-SPONDIN
PRECURSOR.//2.20E-15//366aa//24%//P35447 [2698]
NT2RP70057500//Hypothetical zinc finger-like protein [Homo
sapiens].//0//799aa//94%//AAF88107 [2699] NT2RP70064570//CALPAIN
P94, LARGE [CATALYTIC] SUBUNIT (EC 3.4.22.17) (CALCIUM-ACTIVATED
NEUTRAL PROTEINASE) (CANP) (P94 PROTEIN) (MUSCLE-SPECIFIC
CALCIUM-ACTIVATED NEUTRAL PROTEASE 3 LARGE
SUBUNIT).//9.40E-86//278aa//40%//Q64691 [2700] NT2RP70074800 [2701]
NT2RP70075300//ZINC FINGER PROTEIN 211 (ZINC FINGER PROTEIN
C2H2-25).//9.60E-121//333aa//63%//Q13398 [2702]
NT2RP70075800//HYPOTHETICAL 43.1 KDA TRP-ASP REPEATS CONTAINING
PROTEIN K04G11.4 IN CHROMOSOME X.//1.80E-13//244aa//25%//Q93847
[2703] NT2RP70080150 [2704] NT2RP70084540 [2705]
NT2RP70087140//SKIN SECRETORY PROTEIN XP2 PRECURSOR (APEG
PROTEIN).//1.40E-11//264aa//31%//P17437 [2706] NT2RP70090870//ZINC
FINGER PROTEIN 91 (ZINC FINGER PROTEIN HTF10)
(HPF7).//4.20E-230//592aa//61%//Q05481 [2707] NTONG20002230//Mus
musculus RW1 protein mRNA, complete
cds.//5.20E-97//546aa//34%//AF060565 [2708] NTONG20005310 [2709]
NTONG20017620 [2710] NTONG20029850//CALCYPHOSINE (R2D5
ANTIGEN).//1.60E-24//183aa//32%//P41150 [2711] NTONG20031580//heat
shock 27 kD protein family, member 7 (cardiovascular);
cardiovascular heat shock protein [Homo
sapiens]//6.10E-69//141aa//95%//NP.sub.--055239 [2712]
NTONG20032100//KERATIN, TYPE I CYTOSKELETAL 13 (CYTOKERATIN 13)
(K13) (CK 13).//4.20E-175//351aa//96%//P13646 [2713]
NTONG20034540//CGMP-DEPENDENT 3',5'-CYCLIC PHOSPHODIESTERASE (EC
3.1.4.17) (CYCLIC GMP STIMULATED PHOSPHODIESTERASE)
(CGS-PDE).//0//713aa//99%//000408 [2714] NTONG20035150//RING CANAL
PROTEIN (KELCH PROTEIN).//9.10E-30//570aa//25%//Q04652 [2715]
NTONG20043080//MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE AND
NON-MUSCLE ISOZYMES (EC 2.7.1.117) (MLCK) [CONTAINS:
TELOKIN].//4.30E-12//226aa//28%//P11799 [2716] NTONG20048440//P116
RHO-INTERACTING PROTEIN (P116RIP)
(RIP3).//1.60E-269//588aa//87%//P97434 [2717] NTONG20049180 [2718]
NTONG20053630//GLUCOAMYLASE S1/S2 PRECURSOR (EC 3.2.1.3) (GLUCAN
1,4-ALPHA-GLUCOSIDASE) (1,4-ALPHA-D-GLUCAN
GLUCOHYDROLASE).//1.30E-12//247aa//29%//P08640 [2719]
NTONG20053730//UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 64E (EC
3.1.2.15) (UBIQUITIN THIOLESTERASE 64E) (UBIQUITIN-SPECIFIC
PROCESSING PROTEASE 64E) (DEUBIQUITINATING ENZYME
64E).//8.70E-104//340aa//60%//Q24574 [2720] NTONG20053910//Bos
taurus differentiation enhancing factor 1 (DEF-1) mRNA, complete
cds.//2.50E-198//891aa//45%//AF112886 [2721]
NTONG20055200//ELONGATION FACTOR G, MITOCHONDRIAL PRECURSOR
(MEF-G).//1.10E-269//522aa//83%//Q07803 [2722]
NTONG20058010//ACETYL-COENZYME A SYNTHETASE (EC 6.2.1.1)
(ACETATE-COA LIGASE) (ACYL-ACTIVATING
ENZYME).//3.90E-124//398aa//54%//068040 [2723] NTONG20058220//Homo
sapiens phosphoprotein pp75 mRNA, partial
cds.//8.60E-14//349aa//25%//AF153085 [2724] OCBBF20000740//Homo
sapiens mRNA for ISLR, complete
cds.//3.60E-87//287aa//59%//AB003184 [2725] OCBBF20001780 [2726]
OCBBF20005220//Rattus norvegicus Fos-related antigen mRNA, complete
cds.//3.40E-233//552aa//84%//U34932 [2727] OCBBF20009820 [2728]
OCBBF20011860//Mus musculus epithelial protein lost in neoplasm-a
(Eplin) mRNA, complete cds.//4.30E-33//98aa//66%//AF307844 [2729]
OCBBF20012520//Homo sapiens mRNA for ISLR, complete
cds.//6.50E-88//287aa//59%//AB003184 [2730] OCBBF20016390 [2731]
OCBBF20016810//enhancer of polycomb [Mus
musculus]//0//743aa//92%//AF079765 [2732] OCBBF20109450 [2733]
OCBBF20109780 [2734] OCBBF20110210//KILON PROTEIN PRECURSOR
(KINDRED OF IGLON).//4.30E-182//352aa//94%//Q9Z0J8 [2735]
OCBBF20110730 [2736] OCBBF20111370//BCL2/ADENOVIRUS E1B 19-KDA
PROTEIN-INTERACTING PROTEIN 2.//5.70E-84//324aa//52%//054940 [2737]
OCBBF20111600//69 KDA ISLET CELL AUTOANTIGEN (ICA69) (ISLET CELL
AUTOANTIGEN 1).//1.30E-113//335aa//57%//Q05084 [2738]
OCBBF20112280//Mesembryanthemum crystallinum
phosphoenolpyruvate/phosphate translocator precursor (PPT) mRNA,
complete cds.//7.00E-09//113aa//30%//AF223359 [2739] OCBBF20112320
[2740] OCBBF20113110 [2741] OCBBF20115360 [2742] OCBBF20116250//Mus
musculus C2H2-type zinc finger protein (Evi9) mRNA, complete
cds.//0//592aa//99%//AF051525 [2743] OCBBF20117220 [2744]
OCBBF20118720 [2745] OCBBF20119810 [2746] OCBBF20120010//Homo
sapiens zinc metalloprotease ADAMTS6 (ADAMTS6) mRNA, complete
cds.//1.60E-44//217aa//42%//AF140674 [2747] OCBBF20120950//ZINC
FINGER PROTEIN 151 (POLYOMAVIRUS LATE INITIATOR PROMOTER BINDING
PROTEIN) (LP-1) (ZINC FINGER PROTEIN
Z13).//1.00E-28//201aa//34%//Q60821 [2748] OCBBF20121910//LAF-4
PROTEIN (LYMPHOID NUCLEAR PROTEIN).//0//740aa//98%//P51826 [2749]
OCBBF20123200 [2750] OCBBF20142290 [2751] OCBBF20147070 [2752]
OCBBF20152330 [2753] OCBBF20155030 [2754] OCBBF20156450//ZINC
FINGER PROTEIN 75.//8.20E-163//289aa//99%//P51815 [2755]
OCBBF20157970//ZINC FINGER PROTEIN
135.//2.80E-98//306aa//56%//P52742 [2756] OCBBF20160380//liver
stage antigen LSA-1--Plasmodium
falciparum//1.10E-21//938aa//24%//A45592 [2757] OCBBF20165900//CELL
SURFACE ANTIGEN 114/A10 PRECURSOR.//4.80E-09//145aa//31%//P19467
[2758] OCBBF20165910//Mus musculus pecanex 1 mRNA, complete
cds.//4.20E-116//407aa//53%//AF096286 [2759] OCBBF20166890//RESTIN
(CYTOPLASMIC LINKER PROTEIN-170)
(CLIP-170).//4.20E-21//124aa//45%//042184 [2760]
OCBBF20166900//ZINC FINGER PROTEIN CLONE 647
(FRAGMENT).//9.00E-18//196aa//30%//P15622 [2761]
OCBBF20167290//probable acyl-CoA dehydrogenase--Deinococcus
radiodurans (strain R1)//2.50E-72//222aa//60%//D75616 [2762]
OCBBF20170350//Mus musculus mRNA for GATS
protein.//2.50E-56//121aa//96%//AJ296173 [2763]
OCBBF20174580//G2/MITOTIC-SPECIFIC CYCLIN S13-7 (B-LIKE CYCLIN)
(FRAGMENT).//7.10E-16//240aa//25%//P25012 [2764]
OCBBF20174890//ankyrin 3, long splice
form--human//1.10E-150//178aa//100%//A55575 [2765]
OCBBF20175360//Homo sapiens C2H2 (Kruppel-type) zinc finger protein
mRNA, complete cds.//3.80E-11//101aa//36%//AF159567 [2766]
OCBBF20176650 [2767] OCBBF20177540//ZINC FINGER PROTEIN MLZ-4 (ZINC
FINGER PROTEIN 46).//1.40E-110//223aa//86%//Q03309 [2768]
OCBBF20177910 [2769] OCBBF20182060//Mesocricetus auratus guanine
nucleotide-binding protein beta 5 (Gnb5) mRNA, complete
cds.//7.20E-82//265aa//61%//U13152 [2770] OCBBF20185630 [2771]
OCBBF20188280 [2772] OCBBF20191950//VERY LOW-DENSITY LIPOPROTEIN
RECEPTOR PRECURSOR (VLDL RECEPTOR).//0//720aa//97%//P98155 [2773]
PANCR10000860//ELASTASE IIIB PRECURSOR (EC 3.4.21.70) (PROTEASE
E).//1.10E-52//87aa//97%//P08861 [2774] PEBLM10001470//glutamine
(Q)-rich factor 1, QRF-1 [mice, B-cell leukemia, BCL1, Peptide
Partial, 84 aa]//5.00E-42//84aa//98%//AAB29272 [2775]
PEBLM20001800//IG ALPHA-1 CHAIN C
REGION.//7.90E-197//353aa//100%//P01876 [2776] PEBLM20003260//ZINC
FINGER PROTEIN 83 (ZINC FINGER PROTEIN
HPF1).//4.90E-62//151aa//70%//P51522 PEBLM20005020 [2777]
PLACE50001290//HYPOTHETICAL 87.9 KDA PROTEIN F44G4.1 IN CHROMOSOME
II PRECURSOR.//2.90E-16//102aa//43%//P54073 [2778] PLACE50001390
[2779] PLACE60001910 [2780] PLACE60004260//CYSTATIN M PRECURSOR
(CYSTATIN E).//1.50E-37//81aa//97%//Q15828 [2781] PLACE60006300
[2782] PLACE60011180 [2783] PLACE60012620//LYSOSOMAL TRAFFICKING
REGULATOR (BEIGE HOMOLOG).//8.40E-14//128aa//38%//Q99698
[2784] PLACE60017120 [2785] PLACE60052940//TRANSCRIPTION REGULATORY
PROTEIN GAL11.//1.70E-05//445aa//23%//P32257 [2786] PLACE60053280
[2787] PLACE60054230//DIAPHANOUS PROTEIN HOMOLOG
2.//1.00E-35//385aa//26%//060879 [2788] PLACE60054820//HYPOTHETICAL
PROTEIN KIAA0032.//1.20E-50//180aa//61%//Q15034 [2789]
PLACE60054870//MYOSIN HEAVY CHAIN, NONMUSCLE TYPE B (CELLULAR
MYOSIN HEAVY CHAIN, TYPE B)
(NMMHC-B).//3.70E-11//434aa//20%//P35580 [2790] PLACE60055350
[2791] PLACE60055460//Homo sapiens leucine-zipper protein FKSG13
(FKSG13) mRNA, complete cds.//5.40E-164//327aa//99%//AF312393
[2792] PLACE60055590//MYOSIN-BINDING PROTEIN H (MYBP-H) (H-PROTEIN)
(86 KDA PROTEIN).//1.30E-05//124aa//35%//Q05623 [2793]
PLACE60056910 [2794] PLACE60057860 [2795] PLACE60061370 [2796]
PLACE60062660//ADP-ribosylation factor binding protein GGA1;
ADP-ribosylation factor binding protein; Golgi-associated,
gamma-adaptin ear containing, ARF-binding protein 1 [Homo
sapiens].//6.00E-84//249aa//93%//NP.sub.--037497 [2797]
PLACE60062870 [2798] PLACE60063940 [2799] PLACE60064180//PUTATIVE
PRE-mRNA SPLICING FACTOR ATP-DEPENDENT RNA
HELICASE.//1.90E-51//368aa//37%//022899 [2800]
PLACE60064740//ADHESIVE PLAQUE MATRIX PROTEIN PRECURSOR (FOOT
PROTEIN 1) (MCFP1).//4.80E-11//157aa//31%//Q25434 [2801]
PLACE60066970//ZINC FINGER PROTEIN
191.//1.30E-36//115aa//48%//014754 [2802] PLACE60068710//SUPPRESSOR
PROTEIN SRP40.//9.50E-43//238aa//50%//P32583 [2803] PLACE60069880
[2804] PLACE60070500 [2805] PLACE60071800//CORONIN-LIKE PROTEIN
P57.//3.80E-60//108aa//81%//Q92176 [2806] PLACE60072390 [2807]
PLACE60072420 [2808] PLACE60073090//Homo sapiens myo-inositol
1-phosphate synthase A1 (ISYNA1) mRNA, complete
cds.//6.60E-219//362aa//98%//AF220530 [2809] PLACE60074820 [2810]
PLACE60077870 [2811] PLACE60080360//mucin [Homo
sapiens]//5.50E-05//164aa//30%//CAA84032 [2812] PLACE60081260
[2813] PLACE60082850 [2814] PLACE60087680//INSULIN-LIKE GROWTH.
FACTOR BINDING PROTEIN 3 PRECURSOR (IGFBP-3) (IBP-3) (IGF-BINDING
PROTEIN 3).//2.30E-103//255aa//79%//P17936 [2815] PLACE60088240
[2816] PLACE60092280 [2817] PLACE60092370 [2818] PLACE60093380
[2819] PLACE60095240 [2820] PLACE60095600//HYPOTHETICAL HELICASE
C28H8.3 IN CHROMOSOME III.//2.70E-28//201aa//38%//Q09475 [2821]
PLACE60098350//Human hepatocellular carcinoma associated protein
(JCL-1) mRNA, complete cds.//5.20E-285//558aa//97%//U92544 [2822]
PLACE60104630//macrophage migration inhibitory factor
(glycosylation-inhibiting factor) [Homo
sapiens]//9.70E-51//10aa//93%//XP.sub.--000858 [2823]
PLACE60105680//Homo sapiens mRNA for TU12B1-TY, complete
cds.//1.70E-30//65aa//64%//AB032773 [2824]
PLACE60107010//SUPPRESSOR PROTEIN
SRP40.//3.80E-05//117aa//29%//P32583 [2825] PLACE60109910 [2826]
PLACE60113340//BASEMENT MEMBRANE-SPECIFIC HEPARAN SULFATE
PROTEOGLYCAN CORE PROTEIN PRECURSOR(HSPG) (PERLECAN)
(PLC).//5.90E-65//238aa//32%//Q05793 [2827] PLACE60118810//Rattus
norvegicus kinesin light chain KLCt mRNA, complete
cds.//1.90E-230//504aa//87%//AF166267 [2828] PLACE60119700//Homo
sapiens mRNA for ABP32, complete
cds.//2.30E-21//47aa//100%//AB018357 [2829]
PLACE60120280//SER/THR-RICH PROTEIN T10 IN DGCR
REGION.//6.00E-99//126aa//84%//P54797 [2830] PLACE60122970//novel
C2H2 type zinc finger protein//5.60E-84//169aa//98%//CAC10457
[2831] PLACE60132200//TRICHIOHYALIN.//3.10E-47//297aa//47%//P37709
[2832] PLACE60132320 [2833] PLACE60132880 [2834]
PLACE60138840//PUTATIVE MITOCHONDRIAL CARRIER PROTEIN
PET8.//7.40E-59//274aa//47%//P38921 [2835] PLACE60140640//Homo
sapiens nucleotide binding protein (NBP) mRNA, complete
cds.//3.90E-138//262aa//99%//AF208536 [2836] PLACE60150510//NUCLEAR
PROTEIN SNF7.//1.60E-11//189aa//25%//P39929 [2837]
PLACE60154450//PUTATIVE PREOPTIC REGULATORY FACTOR-2 PRECURSOR
(PORF-2).//7.30E-36//75aa//98%//P18890 [2838] PLACE60155910 [2839]
PLACE60157310 [2840] PLACE60162100 [2841] PLACE60175640 [2842]
PLACE60177880//IGSF5 [Homo
sapiens].//3.60E-174//315aa//99%//CAB90447 [2843] PLACE60177910
[2844] PLACE60181870 [2845] PLACE60184410//Mus musculus peroxisomal
long chain acyl-CoA thioesterase Ib (Pte1b) gene, exon 3 and
complete cds.//1.00E-43//126aa//69%//AF180801 [2846]
PLACE60184870//PHOSPHOLIPID TRANSFER PROTEIN PRECURSOR (LIPID
TRANSFER PROTEIN II).//1.50E-227//330aa//99%//P55058 [2847]
PLACE60188630//Mus musculus mRNA for
acetylglucosaminyltransferase-like
protein.//7.80E-08//317aa//23%//AJ006278 [2848] PROST10001100//Zea
mays clone AGPZm1 arabinogalactan protein (agp) mRNA, partial
cds.//5.80E-05//180aa//32%//AF134579 [2849] PROST10001360 [2850]
PROST10002150 [2851] PROST20007170//Hypothetical Kruppel-Type Zinc
Finger Protein (R28830.sub.--1)//0//432aa//100%//AAC24608 [2852]
PROST20007600//PUTATIVE ENDONUCLEASE C1F12.06C (EC
3.1.-.-).//5.90E-29//134aa//44%//Q10348 [2853] PROST20011160 [2854]
PROST20011800 [2855] PROST20014140 [2856] PROST20014150 [2857]
PROST20014650 [2858] PROST20015210//MYOSIN HEAVY CHAIN, SMOOTH
MUSCLE ISOFORM (SMMHC) (FRAGMENT).//3.00E-107//262aa//85%//P35749
[2859] PROST20015400 [2860] PROST20016760//M-PHASE PHOSPHOPROTEIN 8
(FRAGMENT).//9.00E-157//298aa//99%//Q99549 [2861] PROST20022120
[2862] PROST20024250//ZINC FINGER PROTEIN
136.//1.70E-45//128aa//63%//P52737 [2863]
PROST20028970//Oryctolagus cuniculus CARP mRNA, complete
cds.//4.80E-44//177aa//51%//AF131883 [2864] PROST20033240//EPHRIN
TYPE-A RECEPTOR 6 PRECURSOR (EC 2.7.1.112) (TYROSINE-PROTEIN KINASE
RECEPTOR EHK-2) (EPH HOMOLOGY
KINASE-2).//8.40E-241//441aa//95%//Q62413 [2865]
PROST20035170//Homo sapiens zinc finger protein dp mRNA, complete
cds.//3.40E-15//128aa//42%//AF153201 [2866] PROST20035830 [2867]
PROST20036280 [2868] PROST20036350//MULTIFUNCTIONAL AMINOACYL-TRNA
SYNTHETASE [INCLUDES: GLUTAMYL-TRNA SYNTHETASE (EC 6.1.1.17)
(GLUTAMATE-TRNA LIGASE); PROLYL-TRNA SYNTHETASE (EC 6.1.1.15)
(PROLINE-TRNA LIGASE)].//2.20E-137//651aa//42%//P07814 [2869]
PROST20039300//Bos taurus mitochondrial mRNA for
xenobiotic/medium-chain fatty acid:CoA ligase form
XL-III.//1.60E-68//180aa//68%//AJ132751 [2870] PROST20041460 [2871]
PROST20042700 [2872] PROST20045700//Zea mays clone AGPZm1
arabinogalactan protein (agp) mRNA, partial
cds.//5.80E-05//180aa//32%//AF134579 [2873] PROST20047440 [2874]
PROST20048170 [2875] PROST20050390//CYTOCHROME P450 2J2 (EC
1.14.14.1) (CYPIIJ2) (ARACHIDONIC ACID
EPOXYGENASE).//1.40E-34//188aa//42%//P51589 [2876]
PROST20051310//Homo sapiens DEAD-box protein abstrakt (ABS) mRNA,
complete cds.//8.50E-134//257aa//99%//AF195417 [2877] PROST20052720
[2878] PROST20052850//CYCLIN G-ASSOCIATED KINASE (EC
2.7.1.-).//2.20E-18//107aa//54%//P97874 [2879] PROST20054660 [2880]
PROST20058860//SMALL NUCLEAR RIBONUCLEOPROTEIN ASSOCIATED PROTEINS
B AND B' (SNRNP-B) (SM PROTEIN B/B')
(SM-B/SM-B').//8.20E-05//134aa//33%//P14678 [2881] PROST20060200
[2882] PROST20062820//TRANSLATION INITIATION FACTOR
IF-2.//1.50E-07//102aa//41%//P71613 [2883]
PROST20063430//BCL2/ADENOVIRUS E1B 19-KDA PROTEIN-INTERACTING
PROTEIN 2.//8.50E-74//305aa//46%//Q12982 [2884] PROST20065100
[2885] PROST20065790//6-PHOSPHOFRUCTOKINASE, TYPE C (EC 2.7.1.11)
(PHOSPHOFRUCTOKINASE 1) (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTO-1-KINASE
ISOZYME C) (6-PHOSPHOFRUCTOKINASE, PLATELET
TYPE).//0//697aa//99%//Q01813 [2886] PROST20073280 [2887]
PROST20075280//MYOSIN LIGHT CHAIN KINASE, SMOOTH MUSCLE AND
NON-MUSCLE ISOZYMES (EC 2.7.1.117) (MLCK) [CONTAINS:
TELOKIN].//1.30E-08//245aa//23%//P11799 [2888] PROST20078710 [2889]
PROST20082430 [2890] PROST20084470//Plasmodium berghei strain NYU2
merozoite surface protein-1 mRNA, partial
cds.//2.50E-08//122aa//28%//AF000413 [2891] PROST20084680 [2892]
PROST20084720//CYTOCHROME P450 4F2 (EC 1.14.13.30) (CYPIVF2)
(LEUKOTRIENE-B4 OMEGA-HYDROXYLASE) (LEUKOTRIENE-B4
20-MONOOXYGENASE) (CYTOCHROME
P450-LTB-OMEGA).//1.50E-37//85aa//85%//P78329 [2893] PROST20087240
[2894] PROST20093470 [2895] PROST20094000 [2896] PROST20097310
[2897] PROST20097360 [2898] PROST20097840//SYNAPSIN
I.//1.80E-09//193aa//34%//P17599 [2899] PROST20099090//ADAM 12
PRECURSOR (EC 3.4.24.-) (A DISINTEGRIN AND METALLOPROTEINASE DOMAIN
12) (MELTRIN ALPHA).//1.90E-22//73aa//60%//043184 [2900]
PROST20102190//CALMODULIN.//1.30E-20//98aa//47%//P02594 [2901]
PROST20102500 [2902] PROST20103820 [2903]
PROST20105450//SODIUM/HYDROGEN EXCHANGER 6 (NA(+)/H(+) EXCHANGER 6)
(NHE-6) (KIAA0267).//1.60E-96//214aa//75%//Q92581 [2904]
PROST20106060 [2905] PROST20108850//MICROSOMAL SIGNAL PEPTIDASE 23
KDA SUBUNIT (EC 3.4.-.-) (SPC22/23).//1.20E-69//132aa//100%//P12280
[2906] PROST20110120 [2907] PROST20114100 [2908]
PROST20120070//KINESIN HEAVY CHAIN (UBIQUITOUS KINESIN HEAVY CHAIN)
(UKHC).//5.00E-05//286aa//24%//P33176 [2909] PROST20121570 [2910]
PROST20122490//Gallus gallus syndesmos mRNA, complete
cds.//1.20E-63//139aa//84%//AF095446 [2911] PROST20124000 [2912]
PROST20125420 [2913] PROST20127450//Homo sapiens TSC-22 related
protein (TSC-22R) mRNA, complete
cds.//7.90E-44//95aa//98%//AF153603 [2914] PROST20130320 [2915]
PROST20138730 [2916] PROST20146590//MUCIN 1 PRECURSOR (POLYMORPHIC
EPITHELIAL MUCIN) (PEM) (PEMT) (EPISIALIN) (TUMOR-ASSOCIATED MUCIN)
(CARCINOMA-ASSOCIATED MUCIN) (TUMOR-ASSOCIATED EPITHELIAL MEMBRANE
ANTIGEN) (EMA) (H23AG) (PEANUT-REACTIVE URINARY MUCIN) (PUM)
(BREAST CARCINOMA-ASSOCIATED ANTIGEN
DF3).//3.50E-08//556aa//23%//P15941 [2917] PROST20151370//Human
probable zinc finger protein H101 mRNA, partial
cds.//1.60E-11//104aa//41%//U81557 [2918]
PROST20152510//UDP-N-ACETYLGLUCOSAMINE-PEPTIDE
N-ACETYLGLUCOSAMINYLTRANSFERASE 100 KDA SUBUNIT (EC 2.4.1.-)
(O-GLCNAC TRANSFERASE P100 SUBUNIT).//6.00E-17//148aa//34%//015294
[2919] PROST20152870//Homo sapiens APC2 gene, exon
14.//1.60E-05//195aa//30%//AJ131187 PROST20155370//ZINC FINGER
PROTEIN 38 (ZFP-38) (CTFIN51) (TRANSCRIPTION FACTOR
RU49).//1.10E-72//140aa//55%//Q07231 [2920] PROST20156360 [2921]
PROST20159320 [2922] PROST20168600//Homo sapiens six transmembrane
epithelial antigen of prostate (STEAP1) mRNA, complete
cds.//1.20E-70//237aa//54%//AF186249 [2923] PUAEN10000650//Homo
sapiens TSC-22 related protein (TSC-22R) mRNA, complete
cds.//7.90E-44//95aa//98%//AF153603 [2924] PUAEN10000870 [2925]
PUAEN10001640//Mus musculus cerebellar postnatal development
protein-1 (Cpd1) mRNA, partial cds.//2.80E-126//270aa//90%//U89345
[2926] PUAEN20000800 [2927] PUAEN20001520//L-A VIRUS GAG PROTEIN
N-ACETYLTRANSFERASE (EC 2.3.1.-).//1.70E-34//145aa//51%//Q03503
[2928] PUAEN20002470//PROTEIN
MOV-10.//6.30E-102//405aa//44%//P23249 [2929]
PUAEN20003120//ENHANCER OF ZESTE HOMOLOG 2
(ENX-1).//0//643aa//97%//Q15910 [2930] SALGL10001070//CH-TOG
PROTEIN (COLONIC AND HEPATIC TUMOR OVER-EXPRESSED PROTEIN)
(KIAA0097).//5.30E-150//297aa//96%//Q14008 [2931] SKMUS20006790
[2932] SKMUS20007260//MICROTUBULE-ASSOCIATED PROTEIN 1B (MAP1.2)
(MAP1(X)) [CONTAINS: MAP1 LIGHT CHAIN
LC1].//8.10E-05//396aa//23%//P14873 [2933]
SKMUS20008730//smoothelin large isoform L2 [Homo
sapiens].//1.20E-221//217aa//98%//AAF01481 [2934]
SKMUS20017400//TROPOMYOSIN ALPHA CHAIN, SKELETAL MUSCLE
TYPE.//3.20E-97//242aa//81%//P06753 [2935] SKMUS20020770 [2936]
SKMUS20026340 [2937] SKMUS20040440//60S RIBOSOMAL PROTEIN L3 (HIV-1
TAR RNA BINDING PROTEIN B)
(TARBP-B).//3.60E-189//229aa//99%//P39023 [2938] SKMUS20064810
[2939] SKMUS20073150//20-HYDROXYECDYSONE PROTEIN PRECURSOR
(20-HE).//1.50E-05//129aa//32%//P29681 [2940]
SKMUS20073590//tropomodulin 4 (muscle) [Homo
sapiens]//3.90E-58//115aa//100%//NP.sub.--037485 [2941]
SKMUS20079150//splicing factor 3a, subunit 3, 60 kD; pre-mRNA
splicing factor SF3a (60 kD), similar to S. cerevisiae PRP9
(spliceosome-associated protein 61) [Homo
sapiens]//9.10E-13//65aa//60%//NP.sub.--006793 [2942] SKMUS20091900
[2943] SKNMC10001230//CYCLIN-DEPENDENT KINASE 4 INHIBITOR A (CDK4I)
(P16-INK4) (P16-INK4A) (TUMOR SUPPRESSOR
CDKN2A).//1.60E-08//105aa//38%//077617 [2944] SKNMC20006350//65 KDA
FK506-BINDING PROTEIN PRECURSOR (EC 5.2.1.8) (FKBP65) (FKBPRP)
(PEPTIDYL-PROLYL CIS-TRANS ISOMERASE) (PPIASE) (ROTAMASE)
(IMMUNOPHILIN FKBP65).//1.10E-185//419aa//79%//Q61576 [2945]
SKNSH10001010 [2946] SKNSH20007160 [2947]
SKNSH20009710//TROPOMYOSIN, CYTOSKELETAL TYPE
(TM30-NM).//3.20E-74//174aa//86%//P12324 [2948]
SKNSH20030640//SPLICEOSOME ASSOCIATED PROTEIN 62 (SAP 62)
(SF3A66).//3.00E-06//127aa//33%//Q62203 [2949] SKNSH20040390 [2950]
SKNSH20052400//VEGETATIBLE INCOMPATIBILITY PROTEIN
HET-E-1.//3.60E-17//175aa//29%//Q00808 [2951]
SKNSH20057920//CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE TYPE I
(EC 2.7.1.123) (CAM KINASE I).//5.00E-37//197aa//40%//Q14012 [2952]
SKNSH20068220 [2953] SKNSH20094350 [2954] SMINT20000070//Mus
musculus mRNA for granuphilin-b, complete
cds.//2.70E-44//128aa//41%//AB025259 [2955]
SMINT20002320//SERINE/THREONINE PROTEIN PHOSPHATASE 2A, 56 KDA
REGULATORY SUBUNIT, BETA ISOFORM (PP2A, B SUBUNIT, B' BETA ISOFORM)
(PP2A, B SUBUNIT, B56 BETA ISOFORM) (PP2A, B SUBUNIT, PR61 BETA
ISOFORM) (PP2A, B SUBUNIT, R5 BETA
ISOFORM).//4.70E-160//299aa//100%//Q15173 [2956]
SMINT20006020//faciogenital dysplasia protein 2 [Mus
musculus]//4.10E-158//327aa//87%//AF017368 [2957]
SMINT20006090//Oryctolagus cuniculus mRNA for parchorin, complete
cds.//7.50E-87//175aa//93%//AB035520 [2958]
SMINT20007470//TRICHOHYALIN.//1.20E-37//492aa//28%//Q07283 [2959]
SMINT20008110//CALCIUM-TRANSPORTING ATPASE 2C1 (EC 3.6.1.38)
(ATP-DEPENDENT CA2+ PUMP PMR1).//1.20E-50//165aa//63%//P98194
[2960] SMINT20011830 [2961] SMINT20011950//ZINC FINGER PROTEIN
202.//1.90E-67//426aa//40%//095125 [2962] SMINT20012220 [2963]
SMINT20013970 [2964] SMINT20014610 [2965] SMINT20016150//FERRITIN
LIGHT CHAIN (FERRITIN L SUBUNIT).//3.50E-91//174aa//100%//P02792
[2966] SMINT20017310 [2967] SMINT20021260 [2968] SMINT20023110
[2969] SMINT20024140//IG KAPPA CHAIN V-IV REGION B17
PRECURSOR.//1.20E-60//134aa//87%//P06314 [2970] SMINT20026200//ENL
PROTEIN.//1.10E-05//260aa//24%//Q03111 [2971] SMINT20028800//tumor
supressor protein--fruit fly (Drosophila
melanogaster).//2.00E-78//493aa//34%//T13797 [2972]
SMINT20028840//CMRF35 ANTIGEN
PRECURSOR.//8.40E-19//136aa//41%//Q08708 [2973] SMINT20030740//ZINC
FINGER PROTEIN 136.//4.50E-194//535aa//63%//P52737 [2974]
SMINT20031280 [2975] SMINT20035050//GTPASE ACTIVATING PROTEIN
BEM2/IPL2.//1.20E-07//134aa//26%//P39960 [2976]
SMINT20035510//Drosophila melanogaster La related protein (larp)
mRNA, partial cds.//5.40E-39//334aa//30%//AF221108 [2977]
SMINT20036440//Drosophila melanogaster epsin-like protein mRNA,
complete cds./12.90E-69//446aa//41%//AF233291 [2978]
SMINT20038660//Homo sapiens HNOEL-iso (HNOEL-iso) mRNA, complete
cds.//5.60E-201//368aa//99%//AF201945 [2979] SMINT20039050//Homo
sapiens TRIAD3 mRNA, partial cds.//3.20E-86//156aa//100%//AF228527
[2980] SMINT20043390 [2981] SMINT20044140//ZINC FINGER PROTEIN 84
(ZINC FINGER PROTEIN HPF2).//3.50E-39//440aa//28%//P51523
[2982] SMINT20044730//UBIQUINONE BIOSYNTHESIS PROTEIN
AARF.//6.20E-22//272aa//27%//P27854 [2983] SMINT20045470 [2984]
SMINT20045830 [2985] SMINT20045890 [2986] SMINT20047290 [2987]
SMINT20048720 [2988] SMINT20049920//CYTOSOLIC PURINE
5'-NUCLEOTIDASE (EC 3.1.3.5).//4.10E-39//132aa//57%//P49902 [2989]
SMINT20052130//Rattus norvegicus mRNA for gankyrin homologue,
complete cds.//9.20E-07//104aa//33%//AB022014 [2990]
SMINT20054050//ABC1 PROTEIN HOMOLOG
PRECURSOR.//1.40E-98//467aa//45%//Q92338 [2991] SMINT20056230//Ig
mu chain precursor, membrane-bound (clone
201)--human//5.60E-233//422aa//78%//S14683 [2992] SMINT20056240
[2993] SMINT20062050//PLECTIN.//7.50E-17//436aa//25%//P30427 [2994]
SMINT20067080 [2995] SMINT20070620 [2996] SMINT20074330//tektin A1
[Strongylocentrotus purpuratus]//3.10E-26//125aa//45%//M97188
[2997] SMINT20077920 [2998] SMINT20077960//GELSOLIN PRECURSOR,
PLASMA (ACTIN-DEPOLYMERIZING FACTOR) (ADF) (BREVIN)
(AGEL).//3.30E-246//459aa//99%//P06396 [2999] SMINT20081330 [3000]
SMINT20083290//IG ALPHA-1 CHAIN C
REGION.//4.40E-196//352aa//99%//P01876 [3001] SMINT20084910 [3002]
SMINT20085310 [3003] SMINT20085450 [3004] SMINT20086250//GLYCINE
CLEAVAGE SYSTEM H PROTEIN PRECURSOR.//2.20E-40//70aa//97%//P23434
[3005] SMINT20086720//ZINC FINGER PROTEIN
191.//1.40E-29//109aa//55%//014754 [3006] SMINT20088440//IG KAPPA
CHAIN V-II REGION RPMI 6410
PRECURSOR.//5.10E-44//117aa//78%//P06310 [3007] SMINT20088690
[3008] SMINT20089210 [3009] SMINT20089600//Homo sapiens mRNA for
PICK1, complete cds.//3.10E-145//278aa//100%//AB026491 [3010]
SMINT20091190//IG ALPHA-1 CHAIN C
REGION.//3.70E-198//353aa//99%//P01876 [3011] SMINT20092120 [3012]
SMINT20092160 [3013] SMINT20093630 [3014] SMINT20094150 [3015]
SMINT20094680//Homo sapiens mawbp mRNA for MAWD binding protein,
complete cds.//2.80E-50//77aa//100%//AB049758 [3016] SPLEN20005160
[3017] SPLEN20005370 [3018] SPLEN20006950 [3019] SPLEN20011350
[3020] SPLEN20012450 [3021] SPLEN20015030 [3022]
SPLEN20015100//HYPOTHETICAL 72.5 KDA PROTEIN C2F7.10 IN CHROMOSOME
I.//7.50E-16//121aa//36%//Q09701 [3023] SPLEN20016500 [3024]
SPLEN20017610 [3025] SPLEN20017810 [3026] SPLEN20019120 [3027]
SPLEN20020530 [3028] SPLEN20023430 [3029] SPLEN20023540//H. sapiens
mRNA for F25B3.3 kinase like protein from C.
elegans.//1.50E-205//385aa//99%//Y12336 [3030] SPLEN20023850//DNA
REPAIR PROTEIN RAD18.//3.00E-56//469aa//30%//P53692 [3031]
SPLEN20024190//EGF-containing fibulin-like extracellular matrix
protein 1; fibrillin-like [Homo
sapiens]//3.70E-192//327aa//99%//NP.sub.--061489 [3032]
SPLEN20024510 [3033] SPLEN20024620//Homo sapiens mRNA for acetyl
LDL receptor, complete cds.//1.00E-217//401aa//100%//D86864 [3034]
SPLEN20024770//Rattus norvegicus (rsec6) mRNA, complete
cds.//2.10E-88//545aa//31%//U32575 [3035] SPLEN20024930//Rattus
norvegicus PIPP mRNA for proline-rich inositol polyphosphate
5-phosphatase, complete cds.//0//639aa//91%//AB032551 [3036]
SPLEN20029170 [3037] SPLEN20036780 [3038]
SPLEN20039180//TENSIN.//2.70E-135//341aa//65%//Q04205 [3039]
SPLEN20040780//CORNIFIN B (SMALL PROLINE-RICH PROTEIN 1B) (SPR1B)
(SPR1 B).//5.10E-12//110aa//37%//Q62267 [3040] SPLEN20041810//BC-2
protein [Homo sapiens]//4.00E-24//59aa//96%//AF042384 [3041]
SPLEN20042200//TRANSCRIPTIONAL REPRESSOR
CTCF.//8.40E-22//127aa//33%//P49711 [3042] SPLEN20043430 [3043]
SPLEN20043460 [3044] SPLEN20043680//DNA-REPAIR PROTEIN
COMPLEMENTING XP-D CELLS (XERODERMA PIGMENTOSUM GROUP D
COMPLEMENTING PROTEIN) (DNA EXCISION REPAIR PROTEIN
ERCC-2).//7.30E-171//325aa//99%//P18074 [3045] SPLEN20045550 [3046]
SPLEN20048800//Homo sapiens mRNA for N-Acetylglucosamine
kinase.//1.90E-51//104aa//100%//AJ242910 [3047] SPLEN20049840//M.
musculus mRNA for myosin I.//0//1093aa//89%//X97650 [3048]
SPLEN20050090//TRICHOHYALIN.//7.20E-17//554aa//23%//P37709 [3049]
SPLEN20051420 [3050] SPLEN20054160//Dof protein [Drosophila
melanogaster]//9.60E-14//222aa//29%//AJ010641 [3051]
SPLEN20054500//Homo sapiens mRNA for putative
dipeptidase.//7.10E-130//244aa//100%//AJ295149 [3052]
SPLEN20055600//ZINC FINGER PROTEIN 46 (ZINC FINGER PROTEIN
KUP).//3.00E-56//155aa//63%//P24278 [3053] SPLEN20057830//REGULATOR
OF MITOTIC SPINDLE ASSEMBLY 1
(RMSA-1).//1.10E-16//139aa//43%//P49646 [3054] SPLEN20057900//Homo
sapiens N-acetylglucosamine-1-phosphodiester
alpha-N-acetylglucosaminidase mRNA, complete
cds.//9.00E-75//130aa//93%//AF187072 [3055] SPLEN20058180 [3056]
SPLEN20059270//ZINC-FINGER PROTEIN RFP (RET FINGER
PROTEIN).//7.20E-61//497aa//31%//P14373 [3057] SPLEN20062830 [3058]
SPLEN20063250//zinc finger protein nocA--fruit fly (Drosophila
melanogaster)//9.00E-16//364aa//30%//A55929 [3059]
SPLEN20063890//FIBROMODULIN PRECURSOR (FM) (COLLAGEN-BINDING 59 KDA
PROTEIN).//2.60E-118//242aa//94%//Q06828 [3060] SPLEN20067010
[3061] SPLEN20071820//Homo sapiens DNA polymerase mu (Pol mu) mRNA,
complete cds.//4.70E-62//116aa//100%//AF176097 [3062]
SPLEN20073500//TUMOR NECROSIS FACTOR, ALPHA-INDUCED PROTEIN 2 (B94
PROTEIN).//3.50E-10//463aa//25%//Q03169 [3063] SPLEN20073880 [3064]
SPLEN20076190 [3065] SPLEN20076470//KINESIN LIGHT CHAIN
(KLC).//2.40E-18//137aa//38%//P46825 [3066] SPLEN20080070//TISSUE
ALPHA-L-FUCOSIDASE PRECURSOR (EC 3.2.1.51) (ALPHA-L-FUCOSIDASE I)
(ALPHA-L-FUCOSIDE FUCOHYDROLASE).//4.70E-253//359aa//98%//P04066
[3067] SPLEN20081640 [3068] SPLEN20085910//Homo sapiens protein
activator of the interferon-induced protein kinase (PACT) mRNA,
complete cds.//2.90E-23//52aa//100%//AF072860 [3069] SPLEN20087370
[3070] SPLEN20087860 [3071] SPLEN20090880//HLA CLASS I
HISTOCOMPATIBILITY ANTIGEN, A-24(A-9) ALPHA CHAIN PRECURSOR
(AW-24).//1.40E-66//153aa//83%//P05534 [3072]
SPLEN20098030//TRANSCRIPTION INTERMEDIARY FACTOR 1-BETA (NUCLEAR
COREPRESSOR KAP-1) (KRAB-ASSOCIATED PROTEIN
1).//4.00E-18//267aa//26%//Q13263 [3073] SPLEN20100040//258.1 KDA
PROTEIN C210RF5 (KIAA0933).//7.90E-46//223aa//43%//Q9Y3R5 [3074]
SPLEN20101950//SODIUM/HYDROGEN EXCHANGER 6 (NA(+)/H(+) EXCHANGER 6)
(NHE-6) (KIAA0267).//7.70E-112//353aa//61%//Q92581 [3075]
SPLEN20104150 [3076] SPLEN20104690 [3077] SPLEN20105100 [3078]
SPLEN20108000//Homo sapiens steroid dehydrogenase homolog mRNA,
complete cds.//9.30E-73//155aa//94%//AF078850 [3079] SPLEN20108460
[3080] SPLEN20110180//Homo sapiens golgi membrane protein GP73
mRNA, complete cds.//1.60E-162//347aa//91%//AF236056 [3081]
SPLEN20110210 [3082] SPLEN20110860 [3083] SPLEN20111450 [3084]
SPLEN20114190 [3085] SPLEN20116720//Homo sapiens misato mRNA,
partial cds.//1.00E-277//481aa//89%//AF272833 [3086] SPLEN20117580
[3087] SPLEN20118050//BONE/CARTILAGE PROTEOGLYCAN I PRECURSOR
(BIGLYCAN) (PG-S1).//1.00E-123//240aa//97%//P21810 [3088]
SPLEN20121790 [3089] SPLEN20125230 [3090] SPLEN20126110 [3091]
SPLEN20135030//Homo sapiens PDZ-LIM protein mystique mRNA, complete
cds.//3.30E-92//178aa//97%//AY007729 [3092] SPLEN20136700 [3093]
SPLEN20136730//Homo sapiens RAB-like protein 2A (RABL2A) mRNA,
complete cds.//9.30E-41//102aa//90%//AF095350 [3094] SPLEN20137530
[3095] SPLEN20138600//NUMB protein [Homo
sapiens].//1.00E-97//102aa//100%//AAD01548 [3096]
SPLEN20139100//Human (hybridoma H210) anti-hepatitis A IgG variable
region, constant region, complementarity-determining regions mRNA,
complete cds.//2.30E-227//490aa//85%//M87789 [3097]
SPLEN20139360//MAJOR CENTROMERE AUTOANTIGEN B (CENTROMERE PROTEIN
B) (CENP-B).//5.10E-35//295aa//32%//P07199 [3098] SPLEN20175920
[3099] SPLEN20176130//Homo sapiens mRNA for ALEX1, complete
cds.//9.90E-21//161aa//32%//AB039670 [3100] SPLEN20177400 [3101]
SPLEN20180980//METHIONYL-TRNA SYNTHETASE (EC 6.1.1.10)
(METHIONINE-TRNA LIGASE) (METRS).//3.40E-57//133aa//87%//P56192
[3102] SPLEN20181570//TRICHOHYALIN.//7.80E-45//832aa//23%//P37709
[3103] SPLEN20182850 [3104] SPLEN20182990//Mus musculus
actin-binding protein (ENC-1) mRNA, complete
cds.//1.90E-49//586aa//26%//U65079 [3105] SPLEN20183020//BASEMENT
MEMBRANE-SPECIFIC HEPARAN SULFATE PROTEOGLYCAN CORE PROTEIN
PRECURSOR(HSPG) (PERLECAN) (PLC).//1.20E-24//128aa//46%//Q05793
[3106] SPLEN20183950 [3107] SPLEN20187490//RESTIN (CYTOPLASMIC
LINKER PROTEIN-170 ALPHA-2) (CLIP-170) (REED-STERNBERG INTERMEDIATE
FILAMENT ASSOCIATED PROTEIN).//5.10E-09//411aa//22%//P30622 [3108]
SPLEN20190080 [3109] SPLEN20190430//NEURALIZED
PROTEIN.//2.80E-09//181aa//27%//P29503 [3110] SPLEN20190770 [3111]
SPLEN20191020//Homo sapiens MIST mRNA, partial
cds.//1.50E-207//376aa//99%//AB032369 [3112] SPLEN20192570 [3113]
SPLEN20193230 [3114] SPLEN20193490 [3115] SPLEN20193750 [3116]
SPLEN20193790//INTERFERON-REGULATED RESISTANCE GTP-BINDING PROTEIN
MXA (INTERFERON-INDUCED PROTEIN P78)
(IFI-78K).//0//572aa//98%//P20591 [3117] SPLEN20195710//KINESIN
LIGHT CHAIN (KLC).//5.80E-28//145aa//45%//P46824 [3118]
SPLEN20197090 [3119] SPLEN20197740 [3120] SPLEN20197930//Rattus
norvegicus putative transcription factor LUZP (Luzp) mRNA, complete
cds.//6.10E-124//275aa//90%//AF181259 [3121] SPLEN20198390//TIPD
PROTEIN.//2.80E-52//307aa//37%//015736 [3122] SPLEN20199850 [3123]
SPLEN20200070 [3124] SPLEN20200340 [3125]
SPLEN20201830//BONE/CARTILAGE PROTEOGLYCAN I PRECURSOR (BIGLYCAN)
(PG-S1).//2.50E-152//283aa//100%//P21810 [3126] SPLEN20203590
[3127] SPLEN20204670 [3128] SPLEN20205120 [3129] TESOP10000350
[3130] TESOP10001600 [3131] TESTI10000190//MUCIN 1 PRECURSOR
(POLYMORPHIC EPITHELIAL MUCIN) (PEM) (PEMT) (EPISIALIN)
(TUMOR-ASSOCIATED MUCIN) (CARCINOMA-ASSOCIATED MUCIN)
(TUMOR-ASSOCIATED EPITHELIAL MEMBRANE ANTIGEN) (EMA) (H23AG)
(PEANUT-REACTIVE URINARY MUCIN) (PUM) (BREAST CARCINOMA-ASSOCIATED
ANTIGEN DF3).//1.40E-23//667aa//28%//P15941 [3132] TESTI10000850
[3133] TESTI10001570//ZINC FINGER PROTEIN 84 (ZINC FINGER PROTEIN
HPF2).//1.30E-148//598aa//46%//P51523 [3134]
TESTI20004310//TRICHOHYALIN.//1.40E-07//247aa//25%//P22793 [3135]
TESTI20005980 [3136] TESTI20006160//CALCIUM-BINDING
PROTEIN.//1.10E-11//260aa//28%//P35085 [3137] TESTI20006830//GAR2
PROTEIN.//2.90E-05//221aa//19%//P41891 [3138]
TESTI20012080//TUBULIN-TYROSINE LIGASE (EC 6.3.2.25)
(TTL).//2.20E-22//217aa//35%//P38584 [3139] TESTI20012360 [3140]
TESTI20016970 [3141] TESTI20019590 [3142] TESTI20028020 [3143]
TESTI20029100//FIBROSIN (FRAGMENT).//1.60E-10//70aa//48%//Q60791
[3144] TESTI20030200//DOUBLE-STRANDED RNA-SPECIFIC EDITASE 1 (EC
3.5.-.-) (DSRNA ADENOSINE DEAMINASE) (RNA EDITING ENZYME
1).//1.90E-30//192aa//38%//P51400 [3145]
TESTI20030440//TRICHOHYALIN.//2.80E-21//412aa//26%//P37709 [3146]
TESTI20030610 [3147] TESTI20031310//ALPHA-1-ANTICHYMOTRYPSIN
PRECURSOR (ACT).//7.80E-222//423aa//99%//P01011 [3148]
TESTI20031410//SYNAPTONEMAL COMPLEX PROTEIN 1 (SCP-1
PROTEIN).//6.10E-11//449aa//24%//Q03410 [3149]
TESTI20032770//ANTER-SPECIFIC PROLINE-RICH PROTEIN APG
PRECURSOR.//1.40E-07//121aa//37%//P40602 [3150] TESTI20034750
[3151] TESTI20035330 [3152] TESTI20035790//SPLICING FACTOR,
ARGININE/SERINE-RICH 4 (PRE-mRNA SPLICING FACTOR
SRP75).//2.30E-44//346aa//37%//Q08170 [3153] TESTI20038240//Mus
musculus neprilysin-like metallopeptidase 1 (Nl1) mRNA, complete
cds.//0//770aa//77%//AF176569 [3154] TESTI20040850 [3155]
TESTI20041630//Mus musculus mRNA for type II cytokeratin, complete
cds.//1.30E-151//407aa//75%//AB033744 [3156] TESTI20043130 [3157]
TESTI20043180//mouse mRNA for megakaryocyte potentiating factor,
complete cds.//8.40E-06//392aa//24%//D86370 [3158]
TESTI20043220//ORM1 PROTEIN.//6.40E-21//138aa//37%//P53224 [3159]
TESTI20043910 [3160] TESTI20043990//APOMUCIN (MUCIN CORE PROTEIN)
(FRAGMENT).//8.70E-64//283aa//53%//P12021 [3161]
TESTI20044900//Strongylocentrotus purpuratus radial spokehead mRNA,
complete cds.//2.50E-150//447aa//61%//U73123 [3162]
TESTI20045390//Homo sapiens adlican mRNA, complete
cds.//1.80E-173//632aa//47%//AF245505 [3163] TESTI20045740 [3164]
TESTI20046110 [3165] TESTI20046490//Homo sapiens B2 gene partial
cDNA, clone B2E.//4.30E-33//284aa//34%//AJ002220 [3166]
TESTI20046540 [3167] TESTI20046870//RETINAL-BINDING PROTEIN
(RALBP).//4.00E-06//244aa//23%//P49193 [3168] TESTI20046890//Mus
musculus axotrophin mRNA, complete
cds.//2.30E-40//173aa//53%//AF155739 [3169]
TESTI20047370//ATROPHIN-1 (DENTATORUBRAL-PALLIDOLUYSIAN ATROPHY
PROTEIN).//1.90E-22//695aa//28%//P54258 [3170] TESTI20047930//Homo
sapiens NY-REN-2 antigen mRNA, complete
cds.//1.50E-191//530aa//67%//AF155095 [3171] TESTI20049060//H.
sapiens mRNA for SIRP-beta1.//2.50E-31//172aa//45%//Y10376 [3172]
TESTI20049410 [3173] TESTI20049990 [3174] TESTI20050170 [3175]
TESTI20050400 [3176]
TESTI20050720//SUCCINYL-COA:3-KETOACID-COENZYME A TRANSFERASE
PRECURSOR (EC 2.8.3.5) (SUCCINYL COA:3-OXOACID COA-TRANSFERASE)
(OXCT).//1.40E-208//519aa//74%//P55809 [3177]
TESTI20051200//POLYPEPTIDE N-ACETYLGALACTOSAMINYLTRANSFERASE (EC
2.4.1.41) (PROTEIN-UDP ACETYLGALACTOSAMINYLTRANSFERASE)
(UDP-GALNAC:POLYPEPTIDE, N-ACETYLGALACTOSAMINYLTRANSFERASE)
(GALNAC-T1).//6.10E-50//189aa//49%//Q10472 [3178]
TESTI20051730//MALTOSE PERMEASE.//2.20E-05//327aa//23%//Q45632
[3179] TESTI20052670 [3180] TESTI20053070//HYPOTHETICAL WD-REPEAT
PROTEIN SLL0163.//5.00E-06//172aa//28%//Q55563 [3181] TESTI20053260
[3182] TESTI20053780 [3183] TESTI20053800 [3184] TESTI20053950
[3185] TESTI20054700//Streptococcus pneumoniae strain g375 surface
protein PspC (pspC) gene, pspC-8.1 allele, complete
cds.//6.70E-11//219aa//32%//AF154015 [3186]
TESTI20055680//TRANSLATION INITIATION FACTOR
IF-2.//5.90E-08//98aa//41%//060841 [3187] TESTI20055880 [3188]
TESTI20056030//Homo sapiens 88-kDa Golgi protein (GM88) mRNA,
complete cds.//3.60E-103//316aa//68%//AF204231 [3189] TESTI20057200
[3190] TESTI20057430//ZINC FINGER PROTEIN 8 (ZINC FINGER PROTEIN
HF.18) (FRAGMENT).//3.00E-307//543aa//99%//P17098 [3191]
TESTI20057590//TYROSINE-PROTEIN KINASE-LIKE 7 PRECURSOR(COLON
CARCINOMA KINASE-4) (CCK-4).//7.80E-07//152aa//27%//Q13308 [3192]
TESTI20057840//INHIBITOR OF APOPTOSIS PROTEIN (IAP) (INHIBITOR OF T
CELL APOPTOSIS PROTEIN).//7.20E-08//86aa//36%//Q90660 [3193]
TESTI20057880//CALDESMON (CDM).//6.20E-08//203aa//29%//P12957
[3194] TESTI20058350//SERINE/THREONINE PROTEIN PHOSPHATASE 2A, 55
KDA REGULATORY SUBUNIT B, GAMMA ISOFORM (PP2A, SUBUNIT B, B-GAMMA
ISOFORM) (PP2A, SUBUNIT B, B55-GAMMA ISOFORM) (PP2A, SUBUNIT B,
PR55-GAMMA ISOFORM) (PP2A, SUBUNIT B, R2-GAMMA
ISOFORM).//2.00E-232//426aa//99%//P50410 [3195]
TESTI20058920//TUBULIN ALPHA-3/ALPHA-7
CHAIN.//3.50E-148//277aa//98%//P05214 [3196] TESTI20059080//Homo
sapiens hyaluronidase (LUCA-3) mRNA, complete
cds.//2.40E-170//298aa//100%//AF040710 [3197] TESTI20059330 [3198]
TESTI20059370 [3199] TESTI20059480 [3200] TESTI20059790 [3201]
TESTI20059810//ZINC FINGER PROTEIN 84 (ZINC FINGER PROTEIN
HPF2).//7.50E-153//536aa//52%//P51523 [3202] TESTI20060080//MYOSIN
HEAVY CHAIN, CLONE 203
(FRAGMENT).//5.30E-09//236aa//24%//P39922
[3203] TESTI20060150 [3204] TESTI20060350 [3205] TESTI20060450
[3206] TESTI20060830//Mus musculus mRNA for MIWI (piwi), complete
cds.//0//824aa//94%//AB032604 [3207] TESTI20061090 [3208]
TESTI20061200//NITRITE EXTRUSION PROTEIN (NITRITE
FACILITATOR).//4.90E-05//379aa//23%//P46907 [3209]
TESTI20062120//poly(A)-specific ribonuclease (deadenylation
nuclease); deadenylation nuclease [Homo
sapiens]//1.00E-38//144aa//36%//NP.sub.--002573 [3210]
TESTI20062180 [3211] TESTI20062580 [3212] TESTI20063330 [3213]
TESTI20063410 [3214] TESTI20063600 [3215] TESTI20064370 [3216]
TEST120064530//microtubule-associated protein like echinoderm EMAP
[Homo sapiens].//1.00E-173//562aa//48%//XP.sub.--009139 [3217]
TESTI20064650//Rattus norvegicus myr 6 myosin heavy chain mRNA,
complete cds.//0//645aa//91%//U60416 [3218] TESTI20064990 [3219]
TESTI20065650//INNER CENTROMERE PROTEIN
(INCENP).//1.00E-14//273aa//27%//P53352 [3220] TESTI20066150 [3221]
TESTI20066170 [3222] TESTI20066280 [3223]
TESTI20066330//FIBRONECTIN PRECURSOR.//9.10E-12//408aa//22%//Q91740
[3224] TESTI20066590 [3225] TESTI20066650//CELL DIVISION CONTROL
PROTEIN 25.//2.20E-18//216aa//32%//P04821 [3226] TESTI20067350
[3227] TESTI20067440//INTRACELLULAR PROTEIN TRANSPORT PROTEIN
US01.//2.90E-11//553aa//20%//P25386 [3228] TESTI20067480//ZINC
FINGER PROTEIN 184 (FRAGMENT).//8.60E-134//421 aa//50%//Q99676
[3229] TESTI20068530 [3230] TESTI20068790//TRANS-ACTING
TRANSCRIPTIONAL PROTEIN ICP0 (P135 PROTEIN) (IER
2.9/ER2.6).//7.50E-06//240aa//28%//P29128 [3231] TESTI20068940
[3232] TESTI20070400//Homo sapiens CTL2
gene.//5.90E-229//694aa//55%//AJ245621 [3233] TEST120070740 [3234]
TESTI20071130//MYOSIN HEAVY CHAIN, CARDIAC MUSCLE ALPHA
ISOFORM.//6.30E-09//399aa//23%//Q02566 [3235] TESTI20071630//GLIOMA
PATHOGENESIS-RELATED PROTEIN (RTVP-1
PROTEIN).//5.10E-44//203aa//42%//P48060 [3236] TESTI20073460 [3237]
TESTI20075240//HYPOTHETICAL ZINC FINGER PROTEIN
KIAA0961.//3.20E-145//492aa//56%//Q9Y2G7 [3238] TESTI20076570//Homo
sapiens mitogen-activated protein kinase phosphatase x (MKPX) mRNA,
complete cds.//7.20E-66//126aa//100%//AF165519 [3239] TESTI20076920
[3240] TESTI20079060 [3241] TESTI20079220//ZINC FINGER PROTEIN 29
(ZFP-29).//2.00E-73//281aa//49%//Q07230 [3242]
TESTI20079980//SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-1
(DISHEVELLED-1) (DSH HOMOLOG 1).//7.10E-212//413aa//93%//P51141
[3243] TESTI20080460 [3244] TESTI20081890//SPA-1 like protein p1294
[Rattus norvegicus]//5.80E-129//385aa//41%//AF026504 [3245]
TESTI20083890 [3246] TESTI20084250//OXYSTEROL-BINDING
PROTEIN.//3.70E-183//551aa//62%//P16258 [3247] TESTI20085670 [3248]
TESTI20086840//CARTILAGE MATRIX PROTEIN PRECURSOR
(MATRILIN-1).//3.40E-09//181aa//29%//P05099 [3249]
TESTI20088840//ZINC-FINGER PROTEIN RFP (RET FINGER
PROTEIN).//2.60E-73//258aa//31%//Q62158 [3250] TESTI20089290 [3251]
TESTI20090180 [3252] TESTI20090970 [3253] TESTI20091360 [3254]
TESTI20092170 [3255] TESTI20093900 [3256] TESTI20094620 [3257]
TESTI20095200//HYPOTHETICAL 98.3 KDA PROTEIN B0495.7 IN CHROMOSOME
II.//1.30E-63//328aa//40%//Q09216 [3258] TESTI20095440//probable
membrane protein YOR240w--yeast (Saccharomyces
cerevisiae)//1.00E-25//98aa//55%//S67133 [3259]
TESTI20095770//NEDD1 PROTEIN
(FRAGMENT).//5.80E-297//648aa//85%//P33215 [3260]
TESTI20095880//HYPOTHETICAL SYMPORTER
SLL1374.//3.80E-26//243aa//27%//P74168 [3261] TESTI20097270 [3262]
TESTI20099350//MYOSIN HEAVY CHAIN, NONMUSCLE TYPE B (CELLULAR
MYOSIN HEAVY CHAIN, TYPE B)
(NMMHC-B).//1.50E-26//566aa//23%//P35580 [3263] TESTI20100090//Homo
sapiens endocytic receptor Endo180 (ENDO180) mRNA, complete
cds.//5.00E-161//317aa//93%//AF134838 [3264] TESTI20102390 [3265]
TESTI20103690//Columba livia mRNA for
5'-nucleotidase.//2.70E-114//324aa//66%//AJ131243 [3266]
TESTI20104090//TRANSCRIPTIONAL ENHANCER FACTOR TEF-4 (EMBRYONIC TEA
DOMAIN-CONTAINING FACTOR) (ETF) (ETEF-1)
(TEAD-2).//1.60E-228//450aa//92%//P48301 [3267]
TESTI20105130//MYOTUBULARIN.//4.30E-95//537aa//38%//Q13496 [3268]
TESTI20105910//AMILORIDE-SENSITIVE SODIUM CHANNEL DELTA-SUBUNIT
(EPITHELIAL NA+ CHANNEL DELTA SUBUNIT) (DELTA ENAC)
(NONVOLTAGE-GATED SODIUM CHANNEL 1 DELTA SUBUNIT) (SCNED) (DELTA
NACH).//0//636aa//97%//P51172 [3269] TESTI20106170//Mus musculus
spermatid WD-repeat protein mRNA, complete
cds.//2.20E-167//367aa//83%//AF274321 [3270] TESTI20106820//PROTEIN
KINASE C, ETA TYPE (EC 2.7.1.-) (NPKC-ETA)
(PKC-L).//5.40E-53//97aa//100%//P24723 [3271]
TESTI20107240//EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT
10 (EIF-3 THETA) (EUKARYOTIC TRANSLATION INITIATION FACTOR 3 LARGE
SUBUNIT) (PNLA-35).//5.60E-07//428aa//22%//Q40554 [3272]
TESTI20107320//G1/S-SPECIFIC CYCLIN
C-TYPE.//1.20E-05//130aa//26%//P93411 [3273] TESTI20107340 [3274]
TESTI20108060//SERINE/THREONINE PROTEIN PHOSPHATASE PP1-BETA
CATALYTIC SUBUNIT (EC 3.1.3.16)
(PP-1B).//1.10E-78//145aa//100%//P37140 [3275]
TESTI20112540//CALDESMON (CDM).//9.10E-06//203aa//30%//P12957
[3276] TESTI20112860//MYOSIN LIGHT CHAIN KINASE (EC 2.7.1.117)
(MLCK).//1.60E-54//290aa//40%//P25323 [3277] TESTI20113150 [3278]
TESTI20113940 [3279] TESTI20114480//Human 1(3)mbt protein homolog
mRNA, complete cds.//7.10E-146//582aa//49%//U89358 [3280]
TESTI20116050 [3281] TESTI20116120//Aegilops squarrosa partial
GAG56D gene for gamma-gliadin, accession CIae
24.//3.10E-07//93aa//40%//AJ389681 [3282] TESTI20117500 [3283]
TESTI20118460 [3284] TESTI20120500 [3285] TESTI20120900 [3286]
TESTI20121040//PROBABLE PROTEIN PHOSPHATASE 2C T23F11.1 (EC
3.1.3.16) (PP2C).//8.60E-13//91aa//39%//P49596 [3287]
TESTI20121710//HYPOTHETICAL 57.5 KDA PROTEIN IN VMA7-RPS25A
INTERGENIC REGION.//5.00E-08//292aa//26%//P53214 [3288]
TESTI20122070//Xenopus laevis ER1 mRNA, complete
cds.//1.80E-78//341aa//49%//AF015454 [3289] TESTI20122440 [3290]
TESTI20124440 [3291] TESTI20125280//M-PROTEIN, STRIATED
MUSCLE.//3.60E-68//295aa//46%//Q02173 [3292] TESTI20125440 [3293]
TESTI20125920//G PROTEIN PATHWAY SUPPRESSOR 1 (GPS1 PROTEIN) (MFH
PROTEIN).//5.20E-199//367aa//98%//Q13098 [3294] TESTI20126280//Mus
musculus STAP mRNA for sperm tail associated protein, complete
cds.//4.60E-213//769aa//57%//AB029919 [3295]
TESTI20130530//INSULIN-DEGRADING ENZYME (EC 3.4.24.56) (INSULYSIN)
(INSULINASE) (INSULIN PROTEASE).//1.60E-237//464aa//94%//P14735
[3296] TESTI20131440//CARBOXYPEPTIDASE A1 PRECURSOR (EC
3.4.17.1).//2.80E-107//332aa//58%//P15085 [3297] TESTI20132310
[3298] TESTI20132680 [3299] TESTI20134010 [3300] TESTI20134270
[3301] TESTI20134680//CENTROMERIC PROTEIN E (CENP-E
PROTEIN).//2.40E-08//796aa//19%//Q02224 [3302] TESTI20134970//M.
musculus Tenr mRNA for RNA binding
protein.//5.50E-265//559aa//88%//X84693 [3303]
TESTI20136010//MYOSIN HEAVY CHAIN, NONMUSCLE (CELLULAR MYOSIN HEAVY
CHAIN) (NMMHC).//1.10E-11//438aa//23%//P14105 [3304]
TESTI20140970//V_segment translation product [Homo
sapiens].//6.30E-51//101aa//99%//AAC80210 [3305] TEST120142480
[3306] TESTI20142540//MPV17 PROTEIN.//8.00E-62//116aa//98%//P39210
[3307] TESTI20143180//CENTROMERIC PROTEIN E (CENP-E
PROTEIN).//3.30E-09//507aa//22%//Q02224 [3308]
TESTI20144390//TESTIS-SPECIFIC PROTEIN
PBS13.//6.40E-76//251aa//63%//Q01755 [3309] TESTI20145780//Mus
musculus mRNA for SH2-containing leukocyte protein
65.//1.20E-13//91aa//36%//Y17159 [3310]
TESTI20148380//TRANSFORMATION-SENSITIVE PROTEIN IEF SSP
3521.//2.50E-05//193aa//22%//P31948 [3311] TESTI20149880 [3312]
TESTI20150420//RHO-GTPASE-ACTIVATING PROTEIN 1 (GTPASE-ACTIVATING
PROTEIN RHOGAP) (RHO-RELATED SMALL GTPASE PROTEIN ACTIVATOR) (CDC42
GTPASE-ACTIVATING PROTEIN)
(P50-RHOGAP).//4.50E-09//129aa//34%//Q07960 [3313]
TESTI20150920//PROTEIN PHOSPHATASES PP1 REGULATORY SUBUNIT
SDS22.//2.60E-16//193aa//34%//P22194 [3314] TESTI20151050 [3315]
TESTI20151800 [3316] TESTI20152490 [3317] TEST120153310//LAMIN
B3.//6.30E-13//104aa//41%//P48680 [3318] TESTI20154370//HYALURONAN
MEDIATED MOTILITY RECEPTOR (INTRACELLULAR HYALURONIC ACID BINDING
PROTEIN) (RECEPTOR FOR HYALURONAN-MEDIATED
MOTILITY).//1.10E-07//300aa//21%//075330 [3319] TESTI20159380
[3320] TESTI20161010 [3321] TESTI20162780//COTE1
PROTEIN.//1.00E-107//207aa//99%//P81408 [3322]
TESTI20162980//DNA-DAMAGE INDUCIBLE PROTEIN
DDI1.//1.80E-39//174aa//48%//P40087 [3323] TESTI20164210//PROTEIN
KINASE C-BINDING PROTEIN NELL1 (NEL-LIKE PROTEIN 1)
(FRAGMENT).//1.60E-88//163aa//92%//Q92832 [3324] TESTI20165680
[3325] TESTI20165990 [3326] TESTI20166290//Homo sapiens NY-REN-50
antigen mRNA, partial cds.//3.00E-223//426aa//93%//AF155112 [3327]
TESTI20166670//HOMEOBOX PROTEIN HOX-B1
(HOX-2I).//6.70E-06//224aa//29%//P14653 [3328] TESTI20167580 [3329]
TESTI20168880//BREAKPOINT CLUSTER REGION PROTEIN (EC
2.7.1.-).//2.10E-23//57aa//92%//P11274 [3330]
TESTI20169500//HYPOTHETICAL 51.9 KDA PROTEIN C27F1.04C IN
CHROMOSOME I.//9.50E-17//428aa//25%//Q10173 [3331]
TESTI20170170//Homo sapiens mRNA for chondroitin-4-sulfotransferase
(C4ST gene).//1.10E-53//277aa//40%//AJ269537 [3332] TESTI20170280
[3333] TESTI20170690 [3334] TESTI20170890 [3335]
TESTI20171070//CYCLIC-AMP-DEPENDENT TRANSCRIPTION FACTOR ATF-4
(DNA-BINDING PROTEIN TAXREB67) (CYCLIC AMP RESPONSE ELEMENT-BINDING
PROTEIN 2) (CREB2).//2.60E-63//136aa//91%//P18848 [3336]
TESTI20173050 [3337] TESTI20173110 [3338] TESTI20173960//ZINC
FINGER PROTEIN 91 (ZINC FINGER PROTEIN HTF10)
(HPF7).//1.90E-104//335aa//48%//Q05481 [3339] TESTI20175370//MYOSIN
HEAVY CHAIN, NONMUSCLE (CELLULAR MYOSIN HEAVY CHAIN)
(NMMHC).//1.00E-11//290aa//25%//P14105 [3340]
TESTI20176450//thioredoxin interacting factor [Mus
musculus].//1.00E-75//300aa//46%//AAG32665 [3341] TESTI20179230
[3342] TESTI20179510 [3343] TESTI20180600//Homo sapiens HOM-TES-85
tumor antigen mRNA, complete cds.//8.10E-106//202aa//99%//AF124430
[3344] TESTI20182210 [3345] TESTI20182760//AMILORIDE-SENSITIVE
SODIUM CHANNEL DELTA-SUBUNIT (EPITHELIAL NA+ CHANNEL DELTA SUBUNIT)
(DELTA ENAC) (NONVOLTAGE-GATED SODIUM CHANNEL 1 DELTA SUBUNIT)
(SCNED) (DELTA NACH).//5.90E-185//336aa//99%//P51172 [3346]
TESTI20183680//EARLY NODULIN 20 PRECURSOR
(N-20).//5.10E-08//127aa//37%//P93329 [3347] TESTI20184280 [3348]
TESTI20184750//LAMININ ALPHA-1 CHAIN PRECURSOR (LAMININ A
CHAIN).//2.30E-200//377aa//99%//P25391 [3349] TESTI20184760//ZINC
FINGER PROTEIN 29 (ZFP-29).//9.70E-74//281aa//49%//Q07230 [3350]
TESTI20184820 [3351] TESTI20186110 [3352] TESTI20192570 [3353]
TESTI20193080//GAR22 PROTEIN.//5.10E-153//313aa//92%//Q99501 [3354]
TESTI20193520 [3355] TESTI20194880//PERIOD CIRCADIAN PROTEIN 1
(CIRCADIAN PACEMAKER PROTEIN RIGUI)
(HPER).//1.50E-11//288aa//30%//05534 [3356] TESTI20196690//Bos
taurus pyruvate dehydrogenase phosphatase regulatory subunit
precursor, mRNA, complete cds.//9.10E-114//224aa//92%//AF026954
[3357] TESTI20196970//THIMET OLIGOPEPTIDASE (EC 3.4.24.15)
(ENDOPEPTIDASE 24.15) (MP78).//4.00E-106//147aa//100%//P52888
[3358] TESTI20197030 [3359] TESTI20197290 [3360]
TESTI20197600//TRANSCRIPTIONAL REPRESSOR
CTCF.//5.30E-120//271aa//82%//P49711 [3361] TESTI20198540 [3362]
TESTI20198600 [3363] TESTI20199110//disintegrin-like testicular
metalloproteinase (EC 3.4.24.-) IVb--crab-eating macaque
(fragment)//1.00E-167//331aa//84%//165253 [3364] TESTI20199980
[3365] TESTI20200120 [3366] TESTI20200840 [3367]
TESTI20201760//SYNAPTONEMAL COMPLEX PROTEIN 1 (SCP-1
PROTEIN).//4.70E-09//189aa//25%//Q15431 [3368] TESTI20202830 [3369]
TESTI20204260 [3370]
TESTI20205100//TRICHOHYALIN.//2.60E-15//343aa//24%//P37709 [3371]
TESTI20205150 [3372]
TESTI20205250//phosphatidylinositol-4-phosphate 5-kinase homolog
T3K9.2--Arabidopsis thaliana//4.20E-21//194aa//33%//T02098 [3373]
TESTI20207170//Human testis-specific protein (TSPY) mRNA, complete
cds.//6.60E-111//231aa//96%//U58096 [3374]
TESTI20209050//HYPOTHETICAL 113.1 KDA PROTEIN IN PRE5-FET4
INTERGENIC REGION.//1.90E-05//462aa//22%//Q04893 [3375]
TESTI20210030 [3376] TESTI20210570//RETINAL-BINDING PROTEIN
(RALBP).//5.00E-53//327aa//36%//P49193 [3377] TESTI20211380 [3378]
TESTI20212970//PUTATIVE ATP-DEPENDENT RNA HELICASE
YIR002C.//5.90E-85//458aa//32%//P40562 [3379] TESTI20214630 [3380]
TESTI20215310//Homo sapiens calcyclin binding protein mRNA,
complete cds.//6.60E-95//182aa//100%//AF057356 [3381]
TESTI20219110//TYROSINE-PROTEIN KINASE-LIKE 7 PRECURSOR(COLON
CARCINOMA KINASE-4) (CCK-4).//4.00E-23//53aa//100%//Q13308 [3382]
TESTI20219390 [3383] TESTI20220230//Bos taurus Reissner's fiber
glycoprotein I mRNA, partial cds.//1.20E-10//77aa//50%//AF078930
[3384] TESTI20221790 [3385] TESTI20222030//Homo sapiens very
long-chain acyl-CoA synthetase (BG1) mRNA, complete
cds.//6.10E-172//643aa//50%//AF179481 [3386] TESTI20222460//DYNEIN
GAMMA CHAIN, FLAGELLAR OUTER ARM.//1.50E-138//589aa//46%//Q39575
[3387] TESTI20223380 [3388] TESTI20226520//TUBULIN-TYROSINE LIGASE
(EC 6.3.2.25) (TTL).//6.70E-06//164aa//30%//P38160 [3389]
TEST120227380//DEAD BOX PROTEIN 4 (VASA HOMOLOG)
(RVLG).//1.10E-263//577aa//86%//Q64060 [3390]
TESTI20228120//RHO-GTPASE-ACTIVATING PROTEIN 6 (RHO-TYPE
GTPASE-ACTIVATING PROTEIN RHOGAPX-1)
(FRAGMENT).//4.50E-12//164aa//34%//054834 [3391]
TESTI20228740//ZINC FINGER PROTEIN
135.//3.50E-25//132aa//43%//P52742 [3392] TESTI20244220//MYOSIN
HEAVY CHAIN IB (MYOSIN HEAVY CHAIN
IL).//6.50E-11//77aa//42%//P19706 [3393] TESTI20244430//ANKYRIN 1
(ERYTHROCYTE ANKYRIN) (ANKYRIN R) (ANKYRINS 2.1 AND
2.2).//3.70E-15//173aa//35%//P16157 [3394] TESTI20244460//ADENYLATE
KINASE, CHLOROPLAST (EC 2.7.4.3) (ATP-AMP
TRANSPHOSPHORYLASE).//3.60E-34//209aa//37%//P43188 [3395]
TESTI20244730//Mus musculus alpha/beta hydrolase-1 mRNA, complete
cds.//8.20E-113//266aa//81%//AF189764 [3396]
TESTI20245600//HYPOTHETICAL 118.4 KDA PROTEIN IN BAT2-DAL5
INTERGENIC REGION PRECURSOR.//4.50E-05//236aa//27%//P47179 [3397]
TESTI20245860 [3398] TESTI20246410 [3399] TESTI20246480//Homo
sapiens germline specific RNA binding protein (DAZL1) mRNA,
complete cds.//5.00E-22//86aa//55%//U66726 [3400]
TESTI20247440//Human BLu protein testis isoform (BLu) mRNA,
complete cds.//5.40E-45//91aa//96%//U70880 [3401] TESTI20248850
[3402] TESTI20249360//Homo sapiens DEME-6 mRNA, partial
cds.//4.70E-94//299aa//56%//AF007170 [3403]
TESTI20250220//TRICHOHYALIN.//5.40E-54//537aa//30%//P37709 [3404]
TESTI20250630//Columba livia mRNA for
5'-nucleotidase.//3.80E-115//328aa//66%//AJ131243 [3405]
TESTI20251440//Rattus norvegicus (rsec6) mRNA, complete
cds.//3.80E-31//379aa//28%//U32575 [3406]
TESTI20251610//INTER-ALPHA-TRYPSIN INHIBITOR HEAVY CHAIN H2
PRECURSOR (ITI HEAVY CHAIN H2).//1.10E-07//182aa//26%//002668
[3407] TESTI20251740//FYN-BINDING PROTEIN (SLP-76 ASSOCIATED
PROTEIN) (SLAP-130).//6.30E-16//88aa//50%//015117 [3408]
TESTI20252690//SEGMENT POLARITY PROTEIN DISHEVELLED HOMOLOG DVL-3
(DISHEVELLED-3) (DSH HOMOLOG 3)
(KIAA0208).//4.60E-137//304aa//85%//Q92997
[3409] TESTI20254030//Homo sapiens actin-binding double-zinc-finger
protein (abLIM) mRNA, complete
cds.//6.70E-150//280aa//96%//AF005654 [3410] TESTI20254090 [3411]
TESTI20254480 [3412] TESTI20254990//ZINC FINGER PROTEIN GLI3
(NEURAL SPECIFIC DNA BINDING PROTEIN XGLI3)
(XGLI-3).//6.50E-46//105aa//75%//Q91660 [3413] TESTI20255460//Mus
musculus mRNA for MIWI (piwi), complete
cds.//1.50E-225//864aa//49%//AB032604 [3414] TESTI20256560//NUF1
PROTEIN (SPINDLE POLY BODY SPACER PROTEIN
SPC110).//5.70E-05//590aa//19%//P32380 [3415] TESTI20257910//HLA
CLASS I HISTOCOMPATIBILITY ANTIGEN, ALPHA CHAIN G PRECURSOR (HLA G
ANTIGEN).//1.90E-122//223aa//100%//P17693 [3416]
TESTI20258720//ANKYRIN 1 (ERYTHROCYTE ANKYRIN) (ANKYRIN R)
(ANKYRINS 2.1 AND 2.2).//1.20E-10//233aa//27%//P16157 [3417]
TEST120259110 [3418] TESTI20259200 [3419] TESTI20260140 [3420]
TESTI20260640//helicase II homolog--fruit fly (Drosophila
sp.)//2.70E-27//374aa//27%//T13889 [3421] TESTI20261040//DPY-19
PROTEIN.//2.10E-47//316aa//34%//P34413 [3422] TESTI20261160//Mus
musculus rasGAP-activating-like protein mRNA, complete
cds.//1.60E-21//129aa//41%//AF086714 [3423] TESTI20261680//HEAT
SHOCK PROTEIN 30C.//1.70E-08//136aa//27%//P30218 [3424]
TESTI20262150//Rattus norvegicus mRNA for voltage-gated ca channel,
complete cds.//0//822aa//87%//AB018253 [3425]
TESTI20262940//TUBULIN-TYROSINE LIGASE (EC 6.3.2.25)
(TTL).//5.70E-10//218aa//25%//P38160 [3426] TESTI20264530//PUTATIVE
SERINE/THREONINE-PROTEIN KINASE PKWA (EC
2.7.1.-).//5.60E-18//219aa//34%//P49695 [3427] TESTI20264910 [3428]
TEST120265150 [3429] TESTI20265340 [3430] TESTI20265890 [3431]
TESTI20266050//52 KDA RO PROTEIN (SJOGREN SYNDROME TYPE A ANTIGEN
(SS-A)) (RO(SS-A)).//2.10E-77//472aa//38%//P19474 [3432]
TESTI20268240//Homo sapiens membrane-associated nucleic acid
binding protein mRNA, partial cds.//1.90E-52//412aa//36%//AF255303
[3433] TESTI20269250 [3434] TESTI20269360 [3435]
TESTI20270130//FIBRILLARIN.//2.10E-11//97aa//43%//Q22053 [3436]
TESTI20271790//Human p76 mRNA, complete
cds.//6.9e-317//496aa//99%//U81006 [3437] TESTI20272380 [3438]
TESTI20274960//ZINC FINGER PROTEIN 83 (ZINC FINGER PROTEIN
HPF1).//7.90E-126//342aa//63%//P51522 [3439] TESTI20277300 [3440]
TESTI20278280//Mus musculus p53 apoptosis-associated target (Perp)
mRNA, complete cds.//3.40E-84//155aa//88%//AF249870 [3441]
TESTI20282420//Mus musculus EPCS26 mRNA, complete
cds.//2.40E-19//122aa//33%//AF250838 [3442] TESTI20282530//ZINC
FINGER PROTEIN 135.//1.60E-56//271aa//39%//P52742 [3443]
TESTI20282900 [3444] TESTI20284260//HISTONE H.sub.2B F (H.sub.2B
291A).//2.10E-22//120aa//43%//P10853 [3445]
TESTI20285230//DOUBLE-STRANDED RNA-SPECIFIC EDITASE 1 (EC 3.5.-.-)
(DSRNA ADENOSINE DEAMINASE) (RNA EDITING ENZYME
1).//2.10E-20//192aa//38%//P51400 [3446] TESTI20286590//Human type
3 inositol 1,4,5-trisphosphate receptor (ITPR3) mRNA, complete
cds.//1.00E-93//185aa//100%//U01062 [3447] TESTI20287760 [3448]
THYMU10004280//ZINC-FINGER PROTEIN HT2A (72 KDA TAT-INTERACTING
PROTEIN).//7.90E-13//87aa//42%//Q13049 [3449]
THYMU20006020//ISOCITRATE DEHYDROGENASE [NAD] SUBUNIT ALPHA,
MITOCHONDRIAL PRECURSOR (EC 1.1.1.41) (ISOCITRIC DEHYDROGENASE)
(NAD+-SPECIFIC ICDH).//2.60E-120//229aa//99%//P50213 [3450]
THYMU20007020 [3451] THYMU20007750 [3452] THYMU20008000 [3453]
THYMU20009460 [3454] THYMU20009500 [3455] THYMU20009710 [3456]
THYMU20010180//MOB1 PROTEIN (MPS1 BINDER
1).//2.60E-31//136aa//50%//P40484 [3457] THYMU20010710 [3458]
THYMU20012020 [3459] THYMU20012560 [3460] THYMU20013250//LIM DOMAIN
KINASE 2 (EC 2.7.1.-) (LIMK-2).//3.50E-213//354aa//99%//P53671
[3461] THYMU20013810//Human SEC7 homolog Tic (TIC) mRNA, complete
cds.//2.30E-88//138aa//96%//U63127 [3462] THYMU20014430 [3463]
THYMU20017270 [3464] THYMU20018250 [3465] THYMU20018390 [3466]
THYMU20019000 [3467] THYMU20019260//ZINC FINGER PROTEIN 85 (ZINC
FINGER PROTEIN HPF4) (HTF1).//6.80E-49//137aa//68%//Q03923 [3468]
THYMU20020370 [3469] THYMU20020800//LMBR1 long form [Mus
musculus].//3.00E-69//198aa//55%//AAF91092 [3470]
THYMU20021090//Homo sapiens Sex comb on midleg homolog 1 isoform 1
(SCMH1) mRNA, complete cds.//4.40E-80//149aa//63%//AF149045 [3471]
THYMU20021540 [3472] THYMU20023560//DNA BINDING PROTEIN
RFX2.//6.70E-25//59aa//94%//P48378 [3473]
THYMU20024500//NEUROFILAMENT TRIPLET M PROTEIN (160 KDA
NEUROFILAMENT PROTEIN) (NF-M).//6.20E-06//296aa//22%//P16053 [3474]
THYMU20025480 [3475] THYMU20026950//Mus musculus ROSA 26
transcription AS ROSA26AS mRNA, complete
cds.//2.20E-12//285aa//23%//U83176 [3476] THYMU20028150//AXONIN-1
PRECURSOR (AXONAL GLYCOPROTEIN TAG-1) (TRANSIENT AXONAL
GLYCOPROTEIN 1).//2.20E-33//301aa//31%//Q02246 [3477]
THYMU20028410//Mus musculus Pax transcription activation domain
interacting protein PTIP mRNA, complete
cds.//1.70E-144//345aa//81%//AF104261 [3478] THYMU20029830 [3479]
THYMU20030460//Homo sapiens tumor endothelial marker 7 precursor
(TEM7) mRNA, complete cds.//2.10E-123//230aa//99%//AF279144 [3480]
THYMU20030690 [3481] THYMU20031330//Homo sapiens putative
nucleotide binding protein mRNA, complete
cds.//1.00E-18//64aa//82%//AF118394 [3482] THYMU20032820//ZINC
FINGER PROTEIN 135.//1.40E-82//258aa//55%//P52742 [3483]
THYMU20034400//26S proteasome subunit p44.5 [Homo
sapiens]//8.80E-29//71aa//91%//AB003102 [3484] THYMU20034790 [3485]
THYMU20036500 [3486] THYMU20039320//PUTATIVE
SERINE/THREONINE-PROTEIN KINASE PKWA (EC
2.7.1.-).//1.40E-09//206aa//27%//P49695 [3487] THYMU20043440 [3488]
THYMU20043560 [3489] THYMU20044100 [3490] THYMU20044520 [3491]
THYMU20046350 [3492] THYMU20046770 [3493] THYMU20049060//SPLICING
FACTOR, ARGININE/SERINE-RICH 2 (SPLICING FACTOR SC35) (SC-35)
(SPLICING COMPONENT, 35 KDA) (PR264
PROTEIN).//6.00E-41//119aa//76%//P30352 [3494] THYMU20050010 [3495]
THYMU20051340 [3496] THYMU20052460//PHORBOLIN I
(FRAGMENTS).//5.80E-20//111aa//45%//P31941 [3497]
THYMU20052830//Homo sapiens mRNA for immunoglobulin lambda heavy
chain.//1.50E-237//477aa//90%//Y14737 [3498] THYMU20054800 [3499]
THYMU20055450 [3500] THYMU20055460//ESTERASE D (EC
3.1.1.1).//7.60E-57//107aa//100%//P10768 [3501] THYMU20055740
[3502] THYMU20055760//Mus musculus group IIF secreted phospholipase
A2 (Pla2g2f) mRNA, complete cds.//1.70E-73//165aa//75%//AF166099
[3503] THYMU20058550 [3504] THYMU20060480 [3505] THYMU20062520
[3506] THYMU20062610//DYNEIN GAMMA CHAIN, FLAGELLAR OUTER
ARM.//1.70E-156//585aa//50%//Q39575 [3507]
THYMU20062770//UROMODULIN PRECURSOR (TAMM-HORSFALL URINARY
GLYCOPROTEIN) (THP).//4.20E-22//253aa//28%//P27590 [3508]
THYMU20063650//Homo sapiens mRNA for putative
ribulose-5-phosphate-epimerase, partial
cds.//9.30E-57//116aa//97%//AJ224326 [3509] THYMU20064680 [3510]
THYMU20066660//Homo sapiens putative ATP-dependent RNA helicase
ROK1 mRNA, complete cds.//9.20E-153//361aa//85%//AF077033 [3511]
THYMU20069130 [3512] THYMU20069460 [3513] THYMU20069650 [3514]
THYMU20070250//TRANSKETOLASE (EC 2.2.1.1)
(TK).//4.50E-288//513aa//96%//P29401 [3515] THYMU20071120//ZINC
FINGER PROTEIN 85 (ZINC FINGER PROTEIN HPF4)
(HTF1).//1.40E-229//536aa//74%//Q03923 [3516] THYMU20071460 [3517]
THYMU20072580 [3518] THYMU20073070 [3519] THYMU20073080 [3520]
THYMU20077250//T-CELL-SPECIFIC TRANSCRIPTION FACTOR 1 (TCF-1)
(T-CELL FACTOR 1) (TRANSCRIPTION
FACTOR-7).//4.10E-90//176aa//96%//Q00417 [3521] THYMU20078020
[3522] THYMU20078240 [3523] THYMU20079690 [3524] THYMU20080490
[3525] THYMU20081110//PINCH PROTEIN (PARTICULARY INTERESTING NEW
CYS-HIS PROTEIN).//4.00E-28//60aa//86%//P48059 [3526] THYMU20083390
[3527] THYMU20083500 [3528] THYMU20083830//Homo sapiens angiostatin
binding protein 1 mRNA, complete
cds.//2.30E-09//230aa//28%//AF286598 [3529] THYMU20084520 [3530]
THYMU20086430 [3531] THYMU20087270//POTENTIAL
PHOSPHOLIPID-TRANSPORTING ATPASE IIB (EC
3.6.1.-).//7.20E-154//235aa//88%//P98195 [3532] THYMU20089170
[3533] THYMU20089900 [3534] THYMU20090230//Homo sapiens
ribonucleoprotein mRNA, complete
cds.//9.30E-73//133aa//100%//L32610 [3535] THYMU20091040 [3536]
THYMU20095920//Homo sapiens nuclear prelamin A recognition factor
mRNA, complete cds.//2.90E-94//178aa//100%//AF128406 [3537]
THYMU20096580//SERYL-TRNA SYNTHETASE (EC 6.1.1.11) (SERINE-TRNA
LIGASE) (SERRS).//9.90E-20//45aa//97%//P49591 [3538]
THYMU20097920//mitogen inducible gene
mig-2--human//2.50E-197//477aa//55%//S69890 [3539]
THYMU20098350//KERATIN, TYPE II CYTOSKELETAL 5 (CYTOKERATIN 5) (K5)
(CK 5) (58 KDA CYTOKERATIN).//3.40E-267//577aa//89%//P13647 [3540]
THYMU20099060//IG ALPHA-1 CHAIN C
REGION.//1.70E-196//353aa//99%//P01876 [3541]
THYMU20100940//POTENTIAL PHOSPHOLIPID-TRANSPORTING ATPASE IR (EC
3.6.1.-) (FRAGMENT).//0//646aa//99%//Q9Y2G3 [3542]
THYMU20104480//TRICHOHYALIN.//2.90E-21//300aa//28%//P37709 [3543]
THYMU20106990//Mus musculus evectin-2 (Evt2) mRNA, complete
cds.//2.20E-112//222aa//90%//AF189817 [3544]
THYMU20110720//PROBABLE AMINOTRANSFERASE T01B11.2 (EC
2.6.1.-).//6.90E-40//211aa//41%//P91408 [3545] THYMU20112570 [3546]
THYMU20112590//Homo sapiens AP-4 adaptor complex beta4 subunit
mRNA, complete cds.//3.40E-306//534aa//99%//AF092094 [3547]
THYMU20115380 [3548] THYMU20115730 [3549] THYMU20117850 [3550]
THYMU20120240//Arabidopsis thaliana ubiquitin-specific protease
(AtUBP4) mRNA, complete cds.//4.10E-18//179aa//28%//U76846 [3551]
THYMU20120730//ALDEHYDE DEHYDROGENASE, DIMERIC NADP-PREFERRING (EC
1.2.1.5) (ALDH CLASS 3).//2.10E-203//379aa//99%//P30838 [3552]
THYMU20121040//ELONGATION FACTOR 1-DELTA
(EF-1-DELTA).//5.30E-149//281 aa//99%//P29692 [3553] THYMU20128910
[3554] THYMU20129020 [3555] THYMU20130470 [3556] THYMU20134260
[3557] THYMU20137050 [3558] THYMU20137570 [3559] THYMU20139160
[3560] THYMU20140510 [3561] THYMU20143230//Homo sapiens mRNA for
stabilin-1 (stab1 gene).//1.70E-177//317aa//99%//AJ275213 [3562]
THYMU20145990//nesca protein [Homo
sapiens].//1.90E-152//282aa//98%//NP.sub.--055143 [3563]
THYMU20148010 [3564] THYMU20149230 [3565] THYMU20150190 [3566]
THYMU20151610//Homo sapiens antigen NY-CO-1 (NY-CO-1) mRNA,
complete cds.//1.40E-181//344aa//100%//AF039687 [3567]
THYMU20153210//Homo sapiens Diff33 protein homolog mRNA, complete
cds.//4.00E-120//404aa//54%//AF164794 [3568] THYMU20154790 [3569]
THYMU20157620 [3570] THYMU20163600 [3571] THYMU20170080//Homo
sapiens SIT protein.//9.50E-48//78aa//98%//AJ010059 [3572]
THYMU20170230//Homo sapiens sarcosine dehydrogenase (SARDH) mRNA,
complete cds.//1.80E-183//260aa//99%//AF095735 [3573] THYMU20171580
[3574] THYMU20174490 [3575] THYMU20174790 [3576] THYMU20175260
[3577] THYMU20176010//VEGETATIBLE INCOMPATIBILITY PROTEIN
HET-E-1.//1.80E-20//256aa//28%//Q00808 [3578] THYMU20177070 [3579]
THYMU20178440//Homo sapiens mRNA for immunoglobulin lambda heavy
chain.//2.20E-229//479aa//88%//Y14737 [3580] THYMU20181890 [3581]
THYMU20184550 [3582] THYMU20185470 [3583] THYMU20185650//DIAPHANOUS
PROTEIN HOMOLOG 1.//1.30E-20//85aa//44%//060610 [3584]
THYMU20187210 [3585] THYMU20191970//Homo sapiens FLAMINGO 1 mRNA,
partial cds.//1.80E-54//450aa//36%//AF234887 [3586]
TKIDN10000620//Homo sapiens Tax interaction protein 2 mRNA, partial
cds.//1.20E-56//114aa//100%//AF028824 [3587] TKIDN10001710 [3588]
TKIDN10001920//ZINC FINGER PROTEIN 85 (ZINC FINGER PROTEIN HPF4)
(HTF1).//3.20E-97//226aa//73%//Q03923 [3589]
TRACH20011010//GLUCOAMYLASE S1/S2 PRECURSOR (EC 3.2.1.3) (GLUCAN
1,4-ALPHA-GLUCOSIDASE) (1,4-ALPHA-D-GLUCAN
GLUCOHYDROLASE).//4.30E-17//593aa//22%//P08640 [3590]
TRACH20011540//TUMOR-ASSOCIATED ANTIGEN
L6.//4.70E-57//113aa//97%//P30408 [3591] TRACH20012490 [3592]
TRACH20021000 [3593] TRACH20021380//ADENYLATE CYCLASE, TYPE V (EC
4.6.1.1) (ATP PYROPHOSPHATE-LYASE) (CA(2+)-INHIBITABLE ADENYLYL
CYCLASE).//1.20E-276//492aa//95%//P30803 [3594] TRACH20025370
[3595] TRACH20026640 [3596] TRACH20029880 [3597]
TRACH20040390//MATERNAL PUMILIO
PROTEIN.//1.20E-177//812aa//47%//P25822 [3598] TRACH20041090 [3599]
TRACH20043360//PUTATIVE KINESIN-LIKE PROTEIN
C2F12.13.//2.30E-55//333aa//39%//014343 [3600] TRACH20044990 [3601]
TRACH20049500 [3602] TRACH20051590 [3603] TRACH20057200 [3604]
TRACH20058000 [3605] TRACH20073990 [3606] TRACH20080810 [3607]
TRACH20081270 [3608] TRACH20090060//SYNAPTOTAGMIN
IV.//1.10E-12//301aa//25%//P40749 [3609] TRACH20091070//ALDEHYDE
DEHYDROGENASE, DIMERIC NADP-PREFERRING (EC 1.2.1.5) (ALDH CLASS
3).//1.00E-173//328aa//98%//P30838 [3610]
TRACH20093400//TRICHOHYALIN.//2.30E-13//701aa//20%//P37709 [3611]
TRACH20093480 [3612] TRACH20098510//MYOSIN HEAVY CHAIN, GIZZARD
SMOOTH MUSCLE.//1.10E-20//640aa//21%//P10587 [3613] TRACH20101590
[3614] TRACH20104510 [3615]
TRACH20108240//ribonucleoprotein--African clawed
frog//4.10E-118//223aa//96%//S40774 [3616] TRACH20113020//SELENIDE,
WATER DIKINASE 2 (EC 2.7.9.3) (SELENOPHOSPHATE SYNTHETASE 2)
(SELENIUM DONOR PROTEIN 2).//1.80E-207//364aa//96%//Q99611 [3617]
TRACH20122980//HYPOTHETICAL PROTEIN
MJ0798.//6.80E-13//211aa//22%//Q58208 [3618] TRACH20123870 [3619]
TRACH20124970 [3620] TRACH20125620 [3621] TRACH20129180 [3622]
TRACH20131230//Homo sapiens oxysterol binding protein-related
protein 3 (ORP3) mRNA, complete
cds.//7.50E-282//608aa//62%//AY008372 [3623] TRACH20139280 [3624]
TRACH20140180 [3625] TRACH20143710//RAB GERANYLGERANYLTRANSFERASE
ALPHA SUBUNIT (EC 2.5.1.-) (RAB GERANYL-GERANYLTRANSFERASE ALPHA
SUBUNIT) (RAB GG TRANSFERASE) (RAB
GGTASE).//9.70E-07//142aa//33%//Q92696 [3626]
TRACH20149500//KERATIN, TYPE I CUTICULAR HA6 (HAIR KERATIN, TYPE I
HA6).//1.10E-62//215aa//60%//076013 [3627] TRACH20149720 [3628]
TRACH20149740//EXCITATORY AMINO ACID TRANSPORTER 5 (RETINAL
GLUTAMATE TRANSPORTER).//5.00E-76//152aa//98%//000341 [3629]
TRACH20158240 [3630] TRACH20159390 [3631] TRACH20160800 [3632]
TRACH20163470//Mus musculus putative thymic stromal co-transporter
TSCOT mRNA, complete cds.//3.20E-41//187aa//34%//AF148145 [3633]
TRACH20164100//RETROVIRUS-RELATED PROTEASE (EC
3.4.23.-).//1.40E-32//113aa//56%//P10265 [3634] TRACH20164810
[3635] TRACH20165330 [3636] TRACH20165540//Human alpha-1 type I
collagen gene surrounding osteogenesis imperfecta OI type II
deletion.//4.00E-05//102aa//37%//M11162 [3637] TRACH20167090 [3638]
TRACH20170860//IG DELTA CHAIN C
REGION.//1.60E-212//383aa//100%//P01880 [3639] TRACH20173680//Homo
sapiens mRNA for LAK-4p, complete
cds.//3.50E-80//410aa//38%//AB002405 [3640] TRACH20174980 [3641]
TRACH20182780 [3642] TRACH20185120 [3643] TRACH20188350//Homo
sapiens mRNA for centaurin beta2.//3.80E-60//204aa//56%//AJ238248
[3644] TRACH20190460//MONO- AND DIACYLGLYCEROL LIPASE PRECURSOR (EC
3.1.1.-) (MDGL).//2.60E-11//195aa//28%//P25234 [3645] UMVEN10001380
[3646] UTERU10001060//ETS-DOMAIN PROTEIN
ELK-1.//1.40E-39//88aa//93%//P19419 [3647] UTERU10001870
[3648] UTERU20000230 [3649] UTERU20000950//Homo sapiens PC326
protein (PC326) mRNA, complete
cds.//2.80E-55//112aa//100%//AF150734 [3650] UTERU20011760 [3651]
UTERU20013890 [3652] UTERU20016580//POTENTIAL TRANSCRIPTIONAL
ADAPTOR.//1.90E-37//323aa//31%//Q02336 [3653] UTERU20026620//ZINC
FINGER PROTEIN 75.//7.50E-82//174aa//82%//P51815 [3654]
UTERU20027360 [3655] UTERU20029930 [3656] UTERU20031350 [3657]
UTERU20035770 [3658] UTERU20040150 [3659] UTERU20040370 [3660]
UTERU20040390 [3661] UTERU20040730 [3662] UTERU20041630//ZINC
FINGER PROTEIN 184 (FRAGMENT).//3.30E-75//239aa//44%//Q99676 [3663]
UTERU20041970 [3664] UTERU20045200 [3665] UTERU20051790//guanylate
kinase-interacting protein 1 Maguin-1,
membrane-associated--rat//8.20E-26//267aa//33%//T18293 [3666]
UTERU20064120//MYELOID UPREGULATED
PROTEIN.//1.30E-79//245aa//66%//035682 [3667] UTERU20065470 [3668]
UTERU20079240 [3669] UTERU20083020 [3670] UTERU20086530//GLYCODELIN
PRECURSOR (GD) (PREGNANCY-ASSOCIATED ENDOMETRIAL ALPHA-2 GLOBULIN)
(PEG) (PAEG) (PLACENTAL PROTEIN 14) (PROGESTERONE-ASSOCIATED
ENDOMETRIAL PROTEIN) (PROGESTAGEN-ASSOCIATED ENDOMETRIAL
PROTEIN).//6.00E-73//140aa//99%//P09466 [3671]
UTERU20087070//COMPLEMENT C1R COMPONENT PRECURSOR (EC
3.4.21.41).//4.80E-206//360aa//99%//P00736 [3672]
UTERU20087850//Homo sapiens mRNA for mucolipidin (ML4
gene).//2.70E-34//184aa//42%//AJ293970 [3673] UTERU20089300 [3674]
UTERU20089390//Plectonema boryanum kinesin light chain (KLC) gene,
complete cds.//3.30E-38//216aa//43%//U78597 [3675]
UTERU20089620//Homo sapiens radical fringe (RFNG) gene, partial
cds.//1.50E-31//65aa//100%//AF108139 [3676] UTERU20090940 [3677]
UTERU20091470 [3678] UTERU20094830//SINGLE-MINDED HOMOLOG 2 (SIM
TRANSCRIPTION FACTOR) (MSIM).//8.70E-09//427aa//25%//Q61079 [3679]
UTERU20095100 [3680] UTERU20099040//ZINC TRANSPORTER 2
(ZNT-2).//9.80E-96//242aa//76%//Q62941 [3681] UTERU20099510//ZINC
FINGER PROTEIN 135.//2.20E-107//346aa//54%//P52742 [3682]
UTERU20101150//NUCLEAR FACTOR NF-KAPPA-B P49
SUBUNIT.//2.20E-07//76aa//47%//Q04860 [3683] UTERU20102260 [3684]
UTERU20103040 [3685] UTERU20103200 [3686]
UTERU20104310//DNA-DIRECTED RNA POLYMERASE II 14.4 KDA POLYPEPTIDE
(EC 2.7.7.6) (RPB6) (RPB14.4).//1.80E-48//97aa//100%//P41584 [3687]
UTERU20106510 [3688] UTERU20121140 [3689] UTERU20122520//MOESIN
(MEMBRANE-ORGANIZING EXTENSION SPIKE
PROTEIN).//6.00E-37//399aa//28%//P26042 [3690] UTERU20125810 [3691]
UTERU20127030//LAMININ BETA-2 CHAIN
PRECURSOR(S-LAMININ).//6.80E-175//377aa//92%//P55268 [3692]
UTERU20127150 [3693] UTERU20128560//26.4 KDA PROTEIN IN RUVC-ASPS
INTERGENIC REGION.//2.60E-17//120aa//34%//P24237 [3694]
UTERU20132620//AXONEME-ASSOCIATED PROTEIN MST101
(2).//1.40E-15//231aa//31%//Q08696 [3695] UTERU20134830//pellino
(Drosophila) homolog 2 [Homo
sapiens]//1.40E-153//361aa//72%//NP.sub.--067078 [3696]
UTERU20139760//solute carrier family 25 (mitochondrial carrier;
peroxisomal membrane protein, 34 kD), member 17 [Homo
sapiens]//5.40E-100//203aa//97%//XP.sub.--001136 [3697]
UTERU20140010 [3698] UTERU20167570 [3699] UTERU20168960//Homo
sapiens actin filament associated protein (AFAP) mRNA, complete
cds.//2.60E-68//364aa//43%//AF188700 [3700] UTERU20169020//HOMEOBOX
PROSPERO-LIKE PROTEIN PROX1 (PROX 1).//1.30E-54//117aa//74%//Q91018
[3701] UTERU20173030 [3702] UTERU20176230 [3703]
UTERU20177150//Homo sapiens zinc finger protein dp mRNA, complete
cds.//4.60E-10//104aa//40%//AF153201 [3704] UTERU20181270 [3705]
UTERU20185220//Human mRNA for transcriptional activator hSNF2a,
complete cds.//1.60E-125//246aa//98%//D26155 [3706]
UTERU20188670//HFM1 PROTEIN.//5.10E-19//234aa//26%//P51979 [3707]
UTERU20188840
Sequence CWU 0 SQTB SEQUENCE LISTING The patent application
contains a lengthy "Sequence Listing" section. A copy of the
"Sequence Listing" is available in electronic form from the USPTO
web site
(http://seqdata.uspto.gov/?pageRequest=docDetail&DocID=US20060029945A1).
An electronic copy of the "Sequence Listing" will also be available
from the USPTO upon request and payment of the fee set forth in 37
CFR 1.19(b)(3).
0 SQTB SEQUENCE LISTING The patent application contains a lengthy
"Sequence Listing" section. A copy of the "Sequence Listing" is
available in electronic form from the USPTO web site
(http://seqdata.uspto.gov/?pageRequest=docDetail&DocID=US20060029945A1).
An electronic copy of the "Sequence Listing" will also be available
from the USPTO upon request and payment of the fee set forth in 37
CFR 1.19(b)(3).
* * * * *
References