U.S. patent application number 11/214927 was filed with the patent office on 2005-12-29 for method and composition for improving fertility health in female and male animals and humans.
Invention is credited to Trant, Aileen Sontag.
Application Number | 20050287228 11/214927 |
Document ID | / |
Family ID | 24984736 |
Filed Date | 2005-12-29 |
United States Patent
Application |
20050287228 |
Kind Code |
A1 |
Trant, Aileen Sontag |
December 29, 2005 |
Method and composition for improving fertility health in female and
male animals and humans
Abstract
In a new pharmaceutical combination, the herb, Vitex
agnus-castus (chasteberry), enhances hormone balance by increasing
progesterone release and, therefore, ovulation frequency. The
antioxidants, green tea, vitamin E, and selenium, improve overall
reproductive health. L-arginine, an amino acid, stimulates the
reproductive organs by improving circulation. Folic acid, vitamins
B6 and B12, iron, zinc and magnesium help promote womens'
fertility. Sperms are highly susceptible to free radical or
oxidative damage from environmental toxicants and natural aging.
Vitamins C and E, coenzyme Q10 and selenium are all potent
antioxidants that help improve sperm counts and quality. Ferulic
acid, an antioxidant found in Dong quai, also improves sperm
quality. Zinc and B vitamins (B6, B12 and folate) are critical
nutrients in male reproductive systems for hormone metabolism,
sperm formation and motility. The amino acid, L-carnitine, promotes
formation of healthy sperm.
Inventors: |
Trant, Aileen Sontag;
(Mountain View, CA) |
Correspondence
Address: |
JAMES C. WRAY
1493 CHAIN BRIDGE ROAD
SUITE 300
MCLEAN
VA
22101
US
|
Family ID: |
24984736 |
Appl. No.: |
11/214927 |
Filed: |
August 31, 2005 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
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11214927 |
Aug 31, 2005 |
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10252698 |
Sep 24, 2002 |
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10252698 |
Sep 24, 2002 |
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09742412 |
Dec 22, 2000 |
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6497885 |
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Current U.S.
Class: |
424/641 ;
424/646; 424/682; 424/702; 424/725; 424/729; 514/251; 514/350;
514/52; 514/563 |
Current CPC
Class: |
A61K 33/04 20130101;
A61K 31/195 20130101; A61K 33/26 20130101; A61K 31/355 20130101;
A61K 33/30 20130101; A61K 33/26 20130101; A61K 31/355 20130101;
A61K 31/714 20130101; A61K 33/06 20130101; A61K 31/4415 20130101;
A61K 33/06 20130101; A61K 31/525 20130101; A61K 31/4415 20130101;
A61K 31/525 20130101; A61K 31/714 20130101; A61K 33/04 20130101;
A61K 33/30 20130101; A61K 36/85 20130101; A61K 36/82 20130101; A61K
36/85 20130101; A61K 36/82 20130101; A61K 2300/00 20130101; A61K
31/195 20130101; A61K 2300/00 20130101; A61K 2300/00 20130101; A61K
2300/00 20130101; A61K 2300/00 20130101; A61K 2300/00 20130101;
A61K 2300/00 20130101; A61K 2300/00 20130101; A61K 2300/00
20130101; A61K 2300/00 20130101; A61K 2300/00 20130101 |
Class at
Publication: |
424/641 ;
424/646; 424/702; 424/725; 424/729; 514/251; 514/052; 514/563;
514/350; 424/682 |
International
Class: |
A61K 035/78; A61K
033/04; A61K 033/06; A61K 033/26; A61K 033/32 |
Claims
1-9. (canceled)
10. A supplement, comprising a herb, Vitex agnus-castus
(chasteberry) for enhancing hormone balance, increasing
progesterone release and ovulation frequency, antioxidants, green
tea, vitamin E, and selenium for improving reproductive fertility,
L-arginine, an amino acid for stimulating reproductive organs by
improving circulation, folic acid, vitamins B6 and B12, iron, zinc
and magnesium for promoting women's fertility.
11. A method of promoting fertility health in women comprising
taking a dietary supplement of L-arginine, magnesium, green tea,
vitamin E, Vitex agnus-castus, iron, zinc, selenium, vitamins B6
and B12 and folic acid.
12. The method of claim 11, wherein the dietary supplement further
comprises the following components in percentages by weight: about
50% L-arginine, about 20% magnesium, about 5% green tea, about 11%
vitamin E, about 5% Vitex, about 1% iron, about 1% zinc and less
than about 1% of each selenium, vitamins B6 and B12 and folic
acid.
13. The method of claim 11, wherein the components are present in
the proportion in parts by weight of about 10 to 80% L-arginine, an
amino acid, about 5 to 50% magnesium, about 5 to 50% antioxidants,
including green tea, vitamin E or selenium, 2 to 20% Vitex
agnus-castus (chasteberry), about 0.1 to 10% iron, about 0.1 to 10%
zinc, about 0.001 to 1% folic acid, about 0.001 to 1% vitamins B6
and B12.
14. The method of claim 11, wherein the components are present in
the proportion in parts by weight of about 40 to 80% L-arginine, an
amino acid, about 20 to 50% antioxidants, including green tea,
vitamin E or selenium, about 20 to 50% magnesium, about 4 to 20%
Vitex agnus-castus (chasteberry), about 1 to 10% iron, about 1 to
10 % zinc, about 0.01 to 1% folic acid, and about 0.3 to 1%
vitamins B6 and B12.
15. A method for promoting fertility health in women comprising
taking a supplement having fertility promoting activity in females
comprising in combination components in effective amounts of the
following components present in proportions in parts by weights of
about 10 to 80% L-arginine, an amino acid, about 5 to 50%
magnesium, about 5 to 50% antioxidants, including green tea,
vitamin E or selenium, 2 to 20% Vitex agnus-castus (chasteberry),
about 0.1 to 10% iron, about 0.1 to 10% zinc, about 0.001 to 1%
folic acid, about 0.001 to 1% vitamins B6 and B12.
16. A method for promoting fertility health in women comprising
taking a supplement having fertility promoting activity in females
comprising in combination components in effective amounts of the
following components present in proportions in parts by weights of
about 40 to 80% L-arginine, an amino acid, about 20 to 50%
antioxidants, including green tea, vitamin E or selenium, about 20
to 50% magnesium, about 4 to 20% Vitex agnus-castus (chasteberry),
about 1 to 10% iron, about 1 to 10 % zinc, about 0.01 to 1% folic
acid, and about 0.3 to 1% vitamins B6 and B12.
17. A method for promoting fertility health in women comprising
taking a supplement having fertility promoting activity in females
comprising in combination components in effective amounts of the
following components present in proportions in parts by weights of
about 10 to 80% L-arginine, an amino acid, about 10 to 50%
magnesium, about 5 to 50% antioxidants, including green tea,
vitamin E or selenium, about 1 to 20% Vitex agnus-castus
(chasteberry), about 0.1 to 10% iron.
18. A method of promoting a women's fertility by taking a new
supplement, comprising a herb, Vitex agnus-castus (chasteberry) for
enhancing hormone balance, increasing progesterone release and
ovulation frequency, antioxidants, green tea, vitamin E, and
selenium for improving overall reproductive health, L-arginine, an
amino acid for stimulating reproductive organs by improving
circulation, folic acid, vitamins B6 and B12, iron, zinc and
magnesium for promoting women's' fertility.
19. A supplement for promoting women's fertility comprising an herb
for enhancing hormone balance, increasing progesterone release and
ovulation frequency and an amino acid for stimulating reproductive
organs by improving circulation.
20. The supplement of claim 19, wherein the herb is Vitex
agnus-castus.
21. The supplement of claim 20, wherein the amino acid is
L-arginine.
22. The supplement of claim 21, further comprising one or more
antioxidants for improving reproductive fertility.
23. The supplement of claim 22, wherein the antioxidants are
selected from the group consisting of green tea, vitamin E,
selenium, and combinations thereof.
24. The supplement of claim 22, further comprising folic acid.
25. The supplement of claim 24, further comprising vitamins B6 and
B12.
26. The supplement of claim 25, further comprising iron, zinc and
magnesium.
27. A method of promoting fertility health in women comprising
taking a dietary supplement comprising an herb for enhancing
hormone balance, increasing progesterone release and ovulation
frequency and an amino acid for stimulating reproductive organs by
improving circulation.
28. The method of claim 27, wherein the taking a dietary supplement
comprises taking the supplement comprising L-arginine and Vitex
agnus-castus.
29. The method of claim 27, wherein the taking a dietary supplement
comprises taking the supplement comprising one or more
antioxidants.
30. The method of claim 29, wherein the antioxidants are selected
from the group consisting of green tea, vitamin E, selenium, and
combinations thereof.
31. The method of claim 29, wherein the taking a dietary supplement
comprises taking the supplement comprising iron, magnesium, zinc,
and combinations thereof.
32. The method of claim 31, wherein the taking the supplement
comprises taking the supplement comprising vitamins B6 and B12.
33. The method of claim 32, wherein the taking the supplement
comprises taking the supplement comprising folic acid.
34. The method of claim 33, wherein the dietary supplement further
comprises the following components in percentages by weight: about
50% L-arginine, about 20% magnesium, about 5% green tea, about 11%
vitamin E, about 5% Vitex, about 1% iron, about 1% zinc and less
than about 1% of each of selenium, vitamins B6 and B12 and folic
acid.
35. The method of claim 33, wherein the components are present in
the proportion in parts by weight of about 10 to 80% L-arginine, an
amino acid, about 5 to 50% magnesium, about 5 to 50% antioxidants,
including green tea, vitamin E or selenium, 2 to 20% Vitex
agnus-castus (chasteberry), about 0.1 to 10% iron, about 0.1 to 10%
zinc, about 0.001 to 1% folic acid, about 0.001 to 1% vitamins B6
and B12.
36. The method of claim 33, wherein the components are present in
the proportion in parts by weight of about 40 to 80% L-arginine, an
amino acid, about 20 to 50% antioxidants, including green tea,
vitamin E or selenium, about 20 to 50% magnesium, about 4 to 20%
Vitex agnus-castus (chasteberry), about 1 to 10% iron, about 1 to
10 % zinc, about 0.01 to 1% folic acid, and about 0.3 to 1%
vitamins B6 and B12.
37. A method for promoting fertility health in women comprising
taking a supplement having fertility promoting activity in females
comprising in combination components in effective amounts present
in proportions in parts by weights of about 10 to 80% L-arginine
and about 2 to 20% Vitex agnus-castus.
38. The method of claim 37, further comprising in combination
components in effective amounts present in proportions in parts by
weights of about 5 to 50% magnesium, about 5 to 50% antioxidants
including green tea, vitamin E or selenium, about 0.1 to 10% iron,
about 0.1 to 10% zinc, about 0.001 to 1% folic acid, about 0.001 to
1% vitamins B6 and B12.
39. A method for promoting fertility health in women comprising
taking a supplement having fertility promoting activity in females
comprising in combination components in effective amounts present
in proportions in parts by weights of about 40 to 80% L-arginine
and about 4 to 20% Vitex agnus-castus.
40. The method of claim 39, further comprising in combination
components in effective amounts present in proportions in parts by
weights of about 20 to 50% antioxidants, including green tea,
vitamin E or selenium, about 20 to 50% magnesium, about 1 to 10%
iron, about 1 to 10 % zinc, about 0.01 to 1% folic acid, and about
0.3 to 1% vitamins B6 and B12.
41. A method for promoting fertility health in women comprising
taking a supplement having fertility promoting activity in females
comprising in combination components in effective amounts present
in proportions in parts by weights of about 10 to 80% L-arginine
and about 1 to 20% Vitex agnus-castus.
42. The method of claim 41, further comprising in combination
components in effective amounts present in proportions in parts by
weights of about 10 to 50% magnesium, about 5 to 50% antioxidants
including green tea, vitamin E or selenium, about 0.1 to 10%
iron.
43. A method of promoting a women's fertility by taking a new
supplement, comprising an herb Vitex agnus-castus (chasteberry) for
enhancing hormone balance, increasing progesterone release and
ovulation frequency, an amino acid L-arginine for stimulating
reproductive organs by improving circulation, and antioxidants for
improving overall reproductive health.
44. The method of claim 43, wherein the antioxidants are selected
from the group consisting of green tea, vitamin E, selenium, and
combinations thereof.
45. The method of claim 44, further comprising folic acid, vitamins
B6 and B12, iron, zinc and magnesium for promoting women's
fertility.
46. A supplement for improving fertility health comprising
effective amounts of components of Vitex agnus-castus
(chasteberry), green tea, and L-arginine for improving reproductive
fertility, treating female infertility, enhancing hormone balance,
stimulating reproductive organs, increasing progesterone release,
increasing ovulation rate, and increasing pregnancy rate.
47. The supplement of claim 46, wherein the components are present
in parts by weight of about 74% L-arginine, about 18.5% green tea,
and about 7.4% Vitex agnus-castus (chasteberry).
48. The supplement of claim 46, wherein the components are present
in parts by weight of about 10 to 80% L-arginine, about 5 to 50%
green tea, and about 2 to 20% Vitex agnus-castus (chasteberry).
49. The supplement of claim 46, wherein the components are present
in parts by weight of about 40 to 80% L-arginine, about 20 to 50%
green tea, and about 4 to 20% Vitex agnus-castus (chasteberry).
50. A method for improving and promoting fertility health in women
comprising taking a supplement having fertility promoting activity
in females comprising in combination components in parts by weights
of about 10 to 80% L-arginine, about 5 to 50% green tea, and about
2 to 20% Vitex agnus-castus (chasteberry) for improving
reproductive fertility, treating female infertility, enhancing
hormone balance, stimulating reproductive organs, increasing
progesterone release, increasing ovulation rate, and increasing
pregnancy rate.
51. A method of improving and promoting fertility health in women
comprising taking a dietary supplement of effective amounts of
components of L-arginine, green tea, and Vitex agnus-castus
(chasteberry) for improving reproductive fertility, treating female
infertility, enhancing hormone balance, stimulating reproductive
organs, increasing progesterone release, increasing ovulation rate,
and increasing pregnancy rate.
52. The method of claim 51, wherein the dietary supplement
comprises the components in percentages by weight of about 74%
L-arginine, about 18.5% green tea, and about 7.4% Vitex
agnus-castus (chasteberry).
53. The method of claim 51, wherein the components are present in
the parts by weight of about 10 to 80% L-arginine, about 5 to 50%
green tea, and about 2 to 20% Vitex agnus-castus (chasteberry).
54. The method of claim 51,, wherein the components are present in
parts by weight of about 40 to 80% L-arginine, abbut 20 to 50%
green tea, and about 4 to 20% Vitex agnus-castus (chasteberry).
Description
BACKGROUND OF THE INVENTION
[0001] Because of delayed child bearing, unhealthy diets and use of
tobacco, caffeine, alcohol, drugs and environmental contaminants,
difficulties in conceiving have been experienced.
[0002] Needs exist for pharmaceutical compounds that improve
fertility in both women and men.
SUMMARY OF THE INVENTION
[0003] This invention provides combinations of bioeffecting
compounds for promoting fertility in men and women. The
combinations include nutritional components that benefit fertility
health. All the components have been studied separately, to
determine their individual efficacy. The invention provides the
first products to put these components together synergistically in
women's and men's formulations.
[0004] As many as 15% of couples in the U.S. have difficulty
conceiving a child. In about one third of these cases, it is the
man that is infertile; in another third, the female has fertility
issues. The remaining is due to a combination of male and female
fertility issues, or unknown causes. In many of these cases, causes
of infertility are treatable. Nutritional and lifestyle changes
should be the first step to increasing chances for conception.
Smoking and caffeine, drug and alcohol consumption. environmental
toxicants, and stress are related to infertility in men and women.
Reproductive organs are highly susceptible to free radical or
oxidative damage from environmental toxicants and natural aging. A
balanced, nutritional diet, and nutritional supplements with high
antioxidant content can help reverse some of that damage. In women,
hormone balance is critical to monthly ovulation and development of
the corpus luteum (an ovarian follicle that release progesterone
after release of the egg to prepare the uterus for
implantation).
[0005] These and further and other objects and features of the
invention are apparent in the disclosure, which includes the above
ongoing written specification with the claims.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
[0006] The invention provides combinations of beneficial
bioeffecting compounds for promoting fertility in women. The
invention provides a scientifically validated herbal/nutritional
blend for women to improve infertility by helping to regulate the
menstrual cycle and correct hormone imbalance (corpus luteum
insufficiency) without increased chances of multiple births
associated with drug therapy. The combination of amino acids,
herbs, vitamins and minerals improves overall health and helps with
many of the deficiencies that decrease fertility.
[0007] The herb, Vitex agnus-castus (chasteberry), enhances hormone
balance by increasing progesterone release and, therefore,
ovulation frequency. The antioxidants, green tea, vitamin E, and
selenium, improve overall reproductive health. L-arginine, an amino
acid, stimulates the reproductive organs by improving circulation.
Folic acid, vitamins B6 and B 12, iron, zinc and magnesium help
promote womens' fertility.
[0008] The invention provides combinations of beneficial
bioeffecting compounds for promoting fertility in men. Sperms are
highly susceptible to free radical or oxidative damage from
environmental toxicants and natural aging. Vitamins C and E,
coenzyme Q10 and selenium are all potent antioxidants that help
improve sperm counts and quality. Ferulic acid, an antioxidant
found in Dong quai, also improves sperm quality. Zinc and B
vitamins (B6, B12 and folate) are critical nutrients in male
reproductive systems for hormone metabolism, sperm formation and
motilitv. The amino acid. L-camitine, promotes formation of healthy
sperm.
[0009] The invention provides synergistic action of the
combinations.
[0010] The two dietary supplements in male and female formulas are
useful for men and women. Preferably, the distinct combinations are
taken by both members of a couple in which the female age is
between 21 and 46. The distinct combinations are useful for couples
who have tried for 6 months or more, up to three years, to become
pregnant without success. Preferably, patients take 2-4 capsules
per day of the distinct formulas for three months. In women it is
useful to record their basal temperature daily using thermometers
and charts and to have their blood drawn for progesterone analysis
at day 18-22 of the first menstrual cycle prior to taking the
supplement. For men, it is useful to submit a sperm sample at the
same time for analysis of count and motility. Prior to submitting
sperm samples, 2-4 days abstinence is suggested for best results.
No fevers over 101 degrees in the three months prior to taking the
new combinations should be encountered. It is useful to repeat the
analyses during the fourth menstrual cycle of the study. The first
month is needed to develop baselines, followed by three months of
taking the combinations product or placebo.
[0011] Preferred ranges of the combinations considered in percent
by weight are:
1 Components Minimum % Maximum % Women's formula Vitex
(chasteberry) 2 10 L-arginine 40 60 Green tea 5 20 Vitamin E 5 20
Selenium .01 1 Vitamins B6, B12 .01 1 Folic acid .01 1 Iron .1 5
Magnesium 10 40 Zinc .1 5
[0012]
2 Men's Formula Components Minimum % Maximum % L-carnitine 40 70
Ferulic acid in Dong Quai .1 10 Vitamins C and E 10 30 Coenzyme
coQ10 .1 5 Selenium .01 1 Zinc .1 10 B vitamins .001 1
[0013] Acceptable ranges of womens' and mens' formulations are:
3 Women's Formula Components Minimum % Maximum % Vitex
(chasteberry) 1 20 L-arginine 20 70 Green tea 0 30 Vitamin E 0 30
Selenium 0 2 Vitamins B6, B12 0 2 Folic acid 0 2 Iron 0 7 Magnesium
5 50 Zinc .01 10
[0014]
4 Men's Formula Components Minimum % Maximum % L-carnitine 20 80
Ferulic acid in Dong Quai 0 20 Vitamins C and E .01 40 Coenzyme
coQ10 .01 10 Selenium 0 3 Zinc .01 15 B vitamins 0 5
[0015] Examples of useful formulation in percent by weight are:
5 Women's formula Components Vitex (chasteberry) 5 L-arginine 50
Green tea 11 Vitamin E 11 Selenium .03 Vitamins B6, B12 .03 Folic
acid .03 Iron 1 Magnesium 20 Zinc 1 100%
[0016]
6 Men's Formula Components L-carnitine 60 Ferulic acid in Done Quai
6 Vitamins C and E 25 Coenzyme coQ10 3 Selenium 6 Zinc 5 B Vitamins
4 100%
[0017] While the invention has been described with references to
specific embodiments, modifications and variations of the invention
may be constructed without departing from the scope of the
invention, which is defined in the following ciaims.
* * * * *