U.S. patent application number 11/187921 was filed with the patent office on 2005-12-08 for in-vivo extendable element device and system, and method of use.
This patent application is currently assigned to GIVEN IMAGING LTD.. Invention is credited to Iddan, Gavriel J..
Application Number | 20050272974 11/187921 |
Document ID | / |
Family ID | 34061807 |
Filed Date | 2005-12-08 |
United States Patent
Application |
20050272974 |
Kind Code |
A1 |
Iddan, Gavriel J. |
December 8, 2005 |
In-vivo extendable element device and system, and method of use
Abstract
An in-vivo device, such as an autonomous imager or other
suitable in-vivo device, includes a moveable arm, extendible
element, or proboscis. The in-vivo device may include sensors, such
as imagers, etc. The device may transmit sensing information via,
for example, wireless transmission, or wired transmission.
Inventors: |
Iddan, Gavriel J.; (Haifa,
IL) |
Correspondence
Address: |
PEARL COHEN ZEDEK, LLP
10 ROCKEFELLER PLAZA
SUITE 1001
NEW YORK
NY
10020
US
|
Assignee: |
GIVEN IMAGING LTD.
|
Family ID: |
34061807 |
Appl. No.: |
11/187921 |
Filed: |
July 25, 2005 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
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11187921 |
Jul 25, 2005 |
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10694092 |
Oct 28, 2003 |
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6936003 |
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60421788 |
Oct 29, 2002 |
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Current U.S.
Class: |
600/106 ;
600/101; 600/156 |
Current CPC
Class: |
A61B 1/041 20130101;
A61B 5/0031 20130101; A61B 5/07 20130101; A61B 1/00156
20130101 |
Class at
Publication: |
600/106 ;
600/156; 600/101 |
International
Class: |
A61B 001/00 |
Claims
We claim:
1. An autonomous in-vivo device comprising: a storage tank, wherein
said storage tank is to store a substance; and a movable arm.
2. The device according to claim 1 wherein the substance is
medication.
3. The device according to claim 1 wherein the substance is in-vivo
sample.
4. The device according to claim 3 wherein the sample is a tissue
sample.
5. The device according to claim 1 comprising a pump.
6. The device according to claim 5 wherein the pump is to transfer
material to said tank.
7. The device according to claim 1 comprising a grasper.
8. The device according to claim 1 comprising a sampler.
9. A method for in-vivo sampling with an autonomous in-vivo device
comprising: inserting an autonomous device in vivo, wherein said
device comprises an extendable arm and a storage tank; storing a
substance in the tank.
10. The method according to claim 9 wherein the substance is
medication.
11. The method according to claim 9 wherein the substance is an
in-vivo sample.
12. The method according to claim 9 comprising collecting tissue
samples.
13. The method according to claim 9 comprising pumping a substance
into said storage tank.
14. The method according to claim 9 comprising controlling said arm
from an external source.
15. The method according to claim 9 comprising analyzing the
substance within the storage tank.
16. The method according to claim 15 comprising transmitting
analyzed data outside a patient's body.
Description
RELATED APPLICATION DATA
[0001] The present application is a Continuation Application of
U.S. patent application Ser. No. 10/694,092, filed Oct. 28, 2003,
entitled "IN-VIVO EXTENDABLE ELEMENT DEVICE AND SYSTEM, AND METHOD
OF USE", which claims benefit from prior U.S. Provisional Patent
Application Ser. No. 60/421,788 filed on29 Oct. 2002 and entitled
"IN-VIVO EXTENDABLE ELEMENT DEVICE AND SYSTEM, AND METHOD OF USE",
incorporated by reference herein in its entirety.
FIELD OF THE INVENTION
[0002] The present invention relates to the field of in vivo
diagnosis and therapeutics, more specifically, the present
invention relates to a system and a device for in vivo diagnosis
and therapeutics including an extendable and/or moveable
element.
BACKGROUND
[0003] Devices and methods for performing in-vivo medical
procedures and imagery are known in the art. Such devices may be,
for example, inserted into a patient's body and advanced through
internal lumens or cavities of the body to a site of interest
located inside a patient's body
[0004] One group of in-vivo medical devices includes various
endoscopic systems. The imaging capabilities of such endoscopic
systems may be limited and provide only a partial forward field of
vision, although some endoscope systems do allow for the field of
view to be changed. Additionally, although a variety of medical
instruments may be passed through the endoscopic tube to enable
treatment at a site of interest, such instruments are usually
relatively cumbersome and may require complicated controls and
cause pain or discomfort to a patient.
[0005] Another group of devices for performing in-vivo medical
procedures and imagery includes autonomous in-vivo devices. An
example of such devices may be a swallowable device such as a
capsule having an optical assembly capable of providing images from
inside a body cavity or lumen such as the gastrointestinal (GI)
tract. The design of autonomous in-vivo devices, such as
swallowable capsules, may be subjected to size constraints and
other limitations.
[0006] It would be desirable to have a medical instrument having
improved qualities such as maneuverability and control and
substantially small dimensions that is suitable for a wide variety
of medical tasks, and that in addition may include controls or
devices for manipulating objects, tools or substances within or
external to the device.
SUMMARY OF THE INVENTION
[0007] There is thus provided, according to an embodiment of the
present invention, a typically in vivo system and/or device
including one or more extendable and/or moveable elements or arms,
which may be termed proboscises. The proboscises may, for example,
act as one or more "arms" to perform a variety of tasks or, for
example, may be used to propel, move, stabilize or hold the device.
In some embodiments, the arms or proboscises may be progressively
extendable, and the extension of the proboscis may be.
omni-directionally controlled by, for example, outside direction by
an operator, or autonomously. In another embodiment of the present
invention, an autonomous L in vivo device may include one or more
proboscises. In alternate embodiments, the extendable element may
be Used in a non-medical field or application. The device may be
autonomous, and may include an on-board power supply, such as a
battery or a power receiving system.
[0008] Various suitable structures for an arm or extendible element
may be used. For example, in one embodiment, a plurality of
segments may be used. A set of control wires may connect to the arm
or element, and if segments are used may connect to individual
segments. Devices that may be used to move the arm or element may
include, for example, piezo material, shape memory material,
motors, or other suitable elements
BRIEF DESCRIPTION OF THE DRAWINGS
[0009] The subject matter regarded as the invention is particularly
pointed out and distinctly claimed in the concluding portion of the
specification. The invention, however, both as to organization and
method of operation, together with objects, features and advantages
thereof, may best be understood by reference to the following
detailed description when read with the accompanied drawings in
which:
[0010] FIG. 1A is a block diagram illustration of an in vivo
system, according to an embodiment of the present invention;
[0011] FIG. 1B is a block diagram illustration of an autonomous in
vivo device, according to another embodiment of the present
invention;
[0012] FIG. 1C is a cutaway view of a device including an
extendable element and storage tanks according to an embodiment of
the present invention;
[0013] FIG. 2A is a front cross sectional view of an extendable
element, in accordance with an embodiment of the present
invention;
[0014] FIG. 2B is a side-sectional view of an extendable element,
in accordance with an embodiment of the present invention;
[0015] FIG. 3 illustrates a side cutaway view of a portion of an
extendable element according to an embodiment of the present
invention;
[0016] FIG. 4 illustrates a cutaway view of a portion of an
extendable element, according to one embodiment of the present
invention;
[0017] FIG. 5 illustrates a cross sectional view of the extendable
element of FIG. 4, according to one embodiment of the present
invention;
[0018] FIG. 6 illustrates a piezo element of the extendable element
of FIG. 4, according to one embodiment of the present invention;
and
[0019] FIG. 7 illustrates a capsule with multiple extendable
elements according to an embodiment of the present invention.
[0020] It will be appreciated that for simplicity and clarity of
illustration, elements shown in the figures have not necessarily
been drawn to scale. For example, the dimensions of some of the
elements may be exaggerated relative to other elements for clarity.
Further, where considered appropriate, reference numerals may be
repeated among the figures to indicate corresponding or analogous
elements.
DETAILED DESCRIPTION OF THE INVENTION
[0021] In the following detailed description, numerous specific
details are set forth in order to provide a thorough understanding
of the invention. However it will be understood by those of
ordinary skill in the art that the present invention may be
practiced without these specific details. In other instances,
well-known methods and procedures have not been described in detail
so as not to obscure the present invention.
[0022] Throughout the specification the term "in-vivo procedures"
may relate to any diagnostic and/or therapeutic procedures
performed inside the human body, for example, but not limited to,
procedures of gastroenterology, procedures within or on blood
vessels, procedures of gynecology and laparoscopic surgery
procedures.
[0023] Embodiments of the present invention relate to an in-vivo
system and device including one or more extendable elements or
arms, which may be termed proboscises. In alternate embodiments,
the extendable element may be used in a non-medical field or
application.
[0024] The arm or proboscis may be, for example, progressively
extendable. The extension of the proboscis may be, for example,
omni-directionally controlled.
[0025] In another embodiment of the present invention, an
autonomous in-vivo device may include one or more proboscises.
[0026] Reference is made now to FIG. 1A, which is an illustration
of an in-vivo system according to an embodiment of the present
invention. The system 100 may include one or more extendable arms,
elements or proboscises 102, a tube 104 such as an endoscopic tube,
and, for example, a handpiece 106. Each of the one or more
extendable proboscises 102 are typically located at the distal
portion of the endoscopic tube 104, but in alternate embodiments
may be located at other portions, such as a mid-portion.
[0027] Units such as an illumination source 114, one or more
in-vivo medical instruments 118, and one or more sensors such as
image sensor 116 may also be located at the distal portion of the
tube 104, Other sensors, such as pH sensors, pressure sensors,
etc., may be used. The illumination source 114 (e.g. one or more
LEDs) may be adapted to, for example, illuminate an area inside the
patient's body. The image sensor 116 (e.g. a CMOS image sensor;
other suitable sensors may be used) may be adapted to collect
reflected light. In some embodiments, the illumination source 114
may be configured to output, and the image sensor 116 may be
configured to collect, electromagnetic radiation. The instruments
118 may be suitable in-vivo medical instruments, such as graspers,
blades, clamps, tissue collecting baskets, means for delivering
treatment at a specific location, stents, catheters, suturing
devices, forceps, dilatation balloons, and others. The sensors may
also be suitable sensors, including but not limited to a
temperature sensor, a pH meter, a bio-chemical analyte assay or
identifier, a sensor for determining electrical impedance of
tissues, an optical sensor, such as a spectrometer and other
sensors. The system 100 may include other components or
arrangements of components. For example, in some embodiments, an
imaging system may be omitted.
[0028] In some embodiments, an imaging unit placed on the tube 104
may transmit images wirelessly. For example, the imaging unit and
its use, and a reception and display system which may be used with
the imaging unit, are similar to embodiments disclosed in U.S. Pat.
No. 5,604,531 to Iddan et al. and/or WO 01/65995 entitled "A Device
And System For In Vivo Imaging", published on Sep. 13, 2001, both
of which are hereby incorporated by reference In other embodiments,
other imaging units, receivers and processing units may be
used.
[0029] In one embodiment, the proboscis is approximately 1 mm in
diameter and 15-20 mm in length, but other dimensions may be used.
According to some embodiments of the present invention, each of the
one or more extendable proboscises 102 may be designed to mimic or
include one or more functions of suitable in vivo medical
instrument, sensor or imager, including but not limited to
graspers, blades, clamps, collecting baskets or containers for
tissue or fluid (which may include particles), scalpels, stents,
catheters, suturing devices, forceps, dilatation balloons,
injectors, forceps, anchors, drug applicators, samplers, biopsy
samplers, an electrode or electrodes, suction tubes, temperature
sensors, optical sensors, pH meters, and others. Accordingly, the
proboscis 102 may be adapted to perform, or may include components
allowing it to perform a wide variety of functions. For example,
the extendable proboscis 102 may be adapted to perform tissue
cutting, tissue welding, suturing, cauterizing, ablating, clamping,
biopsy and tissue sampling, optical sensing, chemical sensing,
application of substance, injection of substances, imaging, and
temperature sensing, etc. However it should be noted that the
extendable proboscis 102 of an embodiment of the present invention
may not be limited to such functions or procedures, and that the
extendable proboscis 102 of an embodiment of the present invention
may be designed to perform a wide variety of in vivo functions or
procedures, or to carry or deliver components capable of performing
such functions or procedures. For example, an extendable proboscis
102 according to an embodiment of the present invention may include
an attachment point allowing a, for example, a blade to be attached
and manipulated.
[0030] The proboscis 102 may, for example, be folded or coiled when
in an inactive mode, and possibly contained within a storage
section or cavity, and may be unfolded when in an extended mode.
According to one embodiment of the present invention the extendable
proboscis 102 may be coiled around itself when in inactive mode and
may be partly or fully uncoiled when in extended mode. According to
a further embodiment of the present invention the extension of the
proboscis 102 may be controlled, such that only a selected portion
of the extendable proboscis 102 may be unfolded or alternatively,
the extendable proboscis 102 may be completely unfolded. The
control of the extendable proboscis 102 is discussed in greater
detail herein.
[0031] The tube 104 may be designed and fabricated similarly to
known catheters, endoscopes, needles, stents, laparascopes, rigid
endoscopes and the like, in accordance with specific requirements.
For example, the tube 104 may include a water/air channel or
channels 108, a working channel 110, for passing instruments and
tools, a control channel 112 (which may include, for example, one
or more control wires 115) for passing control wires and conductive
wires, and an illumination channel 113 for passing illumination
fibers through the tube 104. Other components and arrangements of
components may be used. The control wires 115 and the conductive
wires passing through the control channel 112 may be operatively
connected to one or more of the proboscises 102, illumination
source 114, imaging sensor 116, instruments 118 and other sensors.
The control wires may be adapted to pass control signals to one or
more of the proboscises 102, illumination source 114, imaging
sensor 116, instruments 118 and other sensors. The conductive wires
may be adapted to energize one or more of the proboscises 102,
illumination source 114, imaging sensor 116, instruments 118 and
other sensors. Each one of the channels 110, 112 and 113 passing
through the tube 104 may extend from the proximal end of the tube
104 throughout the length of the tube 104 to the distal end of the
tube 104, or, alternately, may extend part way, if appropriate. It
may thus be possible to externally remotely control and energize
one or more of the proboscises 102, illumination source 114,
imaging sensor 116, instruments 118 and other sensors, located
inside the patient's body. In addition, it may be possible to
deliver illumination through the illumination fibers passing
through the illumination channel 113 to an area of interest inside
the patient's body and also to flush or insufflate an area inside
the patient's body by flowing air or water through the air/water
channel or channels 108.
[0032] The handpiece 106 may be operatively connected to the
proximal tip of the endoscopic tube 104, and possibly, to each one
of the channels, wires, fibers or the like, passing therethrough
The handpiece 106 may thus be adapted to control one or more of the
proboscises 102, illumination source 114, imaging sensor 116,
instruments 118 and other sensors, specifically, but not
exclusively, when located inside the patient's body. The handpiece
106 may also be adapted to control the air/water supply to the
air/water channel 108, and the delivery of electromagnetic
radiation to the illumination fibers. The handpiece 106 may include
buttons, levers, pulleys or the like for controlling or regulating
one or more aspects of the operation of one or more of the elements
of the in-vivo medical system 100.
[0033] The in-vivo medical system 100 may further include, for
example, a display unit 121, a processor 122 and controller 124.
Controller 124 may be, for example, a microcontroller,
microprocessor, computer on a chip, or a computer such as a
personal computer or workstation operating software. The display
unit 121 may receive image data or image signals, or other data,
from the image sensor 116 or from other sensors included within
system 100 (e.g , temperature, pressure) and may be adapted to, for
example, display an image or series of images corresponding to the
image data or signals. The processor 122 may receive data from one
or more sensors 116 and may be adapted to process the data. The
processed data may be input to the display unit 121 for display. In
addition or in alternative, the processed data may also be input to
the controller 124.
[0034] The controller 124 may be operatively connected to one or
more of the proboscis 102, illumination source 114, imaging sensor
116, instruments 118 or other sensors. The controller 124 may be
adapted to generate control signals (e g. operation parameters),
possibly, in accordance with the input processed data, for
controlling one or more aspects of the operation of one or more of
the proboscis 102, illumination source 114, imaging sensor 116,
instruments 118 or other sensors. The controller 124 (and/or other
suitable components, such as another suitable controller, receiver,
transceiver, etc) may react to external operator control, e.g., a
human using, for example, a joystick; in such case the controller
124 translates data input from the joystick to control signals
which are sent to the proboscis 102 via, for example, control
wire(s) 115. The controller may react to sensor information and
alter the proboscis 102 position accordingly. In one embodiment
control signals are those such as up/down and left/right, as
described herein.
[0035] The controller 124 may be operated in conjunction with the
handpiece 106 For example, the controller 124 and the handpiece 106
may be adapted to control different aspects, instruments or
functions of the in-vivo medical system 100. However, in accordance
with other embodiments of the present invention, the controller 124
and the handpiece 106 may be adapted to control some of the same
aspects, instruments or functions of the in-vivo medical system 100
and a set of priorities and overrides may be implemented.
[0036] Reference is made now to FIG. 1B, which is a schematic
illustration of an in vivo device, according to an embodiment of
the present invention. In vivo device 200 is typically autonomous
and is typically self contained, but need not be. For example, the
device may be a capsule or other unit where all the components are
substantially contained within a container or shell, and where the
device does not require any wires or cables to, for example,
receive power or transmit information. The device may communicate
with an external receiving and display system to provide display of
data, control, or other functions. For example, power may be
provided by an internal battery or a wireless receiving system.
Other embodiments may have other configurations and capabilities.
For example, components may be distributed over multiple sites or
units. Control information may be received from an external source.
In some embodiments, the in-vivo device and its use, and a
reception and display system which may be used with the device, are
similar to embodiments disclosed in U.S. Pat. No. 5,604,531 to
Iddan et al. and/or International Application publication number WO
01/65995 entitled "A Device And System For In Vivo Imaging",
published on Sep. 13, 2001, each incorporated by reference in its
entirety. The system and method of an embodiment of the present
invention may be used with other suitable autonomous in-vivo
systems, and other suitable reception and display systems, having
different structures and different methods of operation.
[0037] The autonomous in-vivo device 200 may include a container or
housing 201. Within the housing 201, may be, for example, an
optical assembly 202, a power assembly 224, a transceiver 206, one
or more antenna(s) 208, one or more storage tanks 210A and 210B, a
controller 212 and one or more extendable elements or proboscises
214A and 214B. However, some of the above elements or assemblies
may be located partially or completely externally to the housing
201.
[0038] The optical assembly 202 may include, for example, an
optical dome 216. The optical dome 216 may be part of the housing
201 The device 200 may include one or more illumination sources 218
(e.g. white light LED, monochromatic light or any suitable
combination thereof, or other suitable illumination sources), one
or more solid state imagers 220, such as a CMOS image sensor or a
CCD, and one or more optical elements 222, such as focusing lenses
and mirrors. The optical dome 216 may be transparent to wavelengths
used for imaging by the imager 220. The one or more illumination
sources 218 may be adapted to illuminate a selected area. In some
embodiments, the illumination sources 218 may be adapted to produce
electromagnetic radiation having specific spectra. Filters (not
shown) may be used in conjunction with one or more of the
illumination sources 218 to produce light having specific spectra.
Optionally, at least a portion of the electromagnetic radiation may
be manipulated by the optical elements 222, prior to exiting the
dome 216. A portion of the electromagnetic radiation may be
reflected back through the optical dome 216, possibly from an area
inside the patient's body. At least a portion of the reflected
electromagnetic radiation may be received by the solid state imager
220. Optionally, the reflected electromagnetic radiation may be
manipulated by the optical elements 222, prior to being received by
the solid state imager 220. In alternate embodiments, the system
and method of an embodiment of the present invention may be used
with an autonomous capsule without an imager.
[0039] The power assembly 224 may include one or more batteries
224A and 224B. Batteries 224A and 224B may include, for example,
silver oxide batteries, lithium batteries, or other electrochemical
cells having a high energy density, rechargeable batteries, or the
like, but may include other suitable elements. The batteries 224A
and 224B may be operatively connected to one or more of the
elements of the in-vivo device 200, such that the batteries 224A
and 224B may be adapted to energize one or more of these elements.
For example, the power assembly 224 may be operatively connected to
one or more of the illumination sources 218, the solid state imager
220, the proboscis 214A and 214B, the storage tanks 210A and 210B,
the controller 212, the transceiver 206 and/or the antenna(s) 208
According to some embodiments of the present invention, an internal
power source may be a device to receive power induced from an
external source For example, power assembly 224 may include a
suitable power receiving unit, for receiving power from an external
source. The power may be induced, for example, in the form of radio
waves or magnetic waves, from a source located outside the
patient's body (not shown) and a converter located within the
housing 201, for example part of power assembly 224, may be adapted
receive the waves, convert them to energy and supply the energy to
each of the one or more elements located inside the housing 201.
The converter may be adapted to convert the energy to a suitable
form, including but not limited to, electricity, magnetic field,
electromagnetic radiation, chemical potential, or the like.
According to another embodiment of the present invention, the
housing 201 may be connected to an external energy source (not
shown) using one or more wires (not shown). The wires may be
operatively connected to the housing 201 at one end, and to the
external energy source at the other end. Alternatively, the wires
may be operatively connected directly to each of the one or more
elements of interest, located inside the housing 201. It may thus
be possible to power one or more of the elements located inside the
housing 201 using an external power source.
[0040] Transceiver 206 may operate using, for example, radio waves,
ultrasonic transmission, or other suitable transmission methods.
The transceiver 206 may include one or more receivers and one or
more transmitters. The transceiver 206 may be a receiver or may be
a transmitter, or if suitable, both. Altematively, the receivers
and transmitters may be combined in a single transceiver element or
a transceiver array. In an embodiment where the input of data is
not required, the transceiver 206 may be a one-way transmitter.
[0041] Control of the device 200, including control of the
proboscis 214A and 214B, may be similar to that described above,
with FIG. 1A. The transceiver 206 may be operatively connected to
one or more antenna(s) 208, which may include an antenna array. The
transceiver 206 together with the antenna(s) 208 may be adapted to
receive incoming communications from outside the body (e.g.,
control signals or movement signals), and to transmit outgoing
communications from inside the housing 201 to a destination located
outside the patient's body. Typically, such transmissions are
performed using radio waves, although other transmission methods
are possible For example, wired transmission may be used The
controller 212 may be operatively connected to the transceiver 206
and to one or more of the proboscises 214A and 214B, illumination
source 218, solid state imagers 220, optical elements 222,
batteries 224A and 224B, antenna(s) 208 or any other elements
within the housing 201.
[0042] The controller 212 may include a processor (not shown), such
as a microcontroller or a computer on a chip. The processor may
input inbound signals received by the transceiver 206 and may
process the inbound signal The inbound signals may be, for example,
control signals generated by a user externally, for controlling one
or more aspects of the operation of the autonomous in-vivo device
200. Typically, the autonomous in-vivo device 200 may be suitable
for a single use. The processor may also receive outbound signals
(e.g. image signals from the solid state imager 220, power level of
the batteries 224A and 224B, treatment parameters obtained by the
proboscis 214A and 214B, etc.), process the outbound signals and
output the processed outbound signal to the transceiver 206 for
transmission outside of the patent's body. In alternate
embodiments, different components or sets of components may be
used. For example, the controller 212 may be part of, combined
with, or integrated within the transceiver 206 or a transmitter.
Controller 212 may, for examples, send movement signals or control
signals to an arm or extendible element such as proboscis 214.
[0043] In one embodiment, for each proboscis 214, control signals
such as up/down and left/right, or up/down for each segment and
left/right for each segment, or other signals, are received by
transceiver 206, possibly. modified (e.g., amplified, processed to
be more suitable for the proboscis), and sent to the proboscis 214.
Other control signals, such as to operate a tool, open a valve on a
tank, inject, etc., may be included and sent to the proboscis 214
or appropriate section of the proboscis. Such control signals may
be supervised and initiated by an external operator reacting to
signals sent from the device 200; for example video signals. The
control signals sent from an external source may be based on, for
example, a mathematical model of the proboscis dynamics which may
help in generating the proper commands. Alternately, such control
signals may be modified by, for example, controller 212 or
transceiver 206 based on such models.
[0044] The extendable proboscises 214A and 214B may be housed
within the housing 201 when in retracted mode (e.g. 214B), and may
extend out of the housing 201 when in extended (e.g. 214A) or
partially extended mode. Optionally, when in retracted mode, the
proboscises 214A and 214B may be coiled around themselves. In some
embodiments, arms or extendible elements such as proboscises 214A
and 214B need not be retracted within a housing, or retracted or
folded (e.g., retracted or folded against a housing) at any point
For example, a device 200 may be inserted (e.g., ingested) with
arms, extendable elements, or proboscises partially or completely
extended.
[0045] According to some embodiments of the present invention, the
proboscises 214A and 214B may be designed to functionally mimic or
to carry or move suitable in-vivo medical instruments, sensors or
imagers, including but not limited to graspers, blades, clamps,
tissue collecting baskets, scalpels, stents, catheters, suturing
devices, forceps, dilatation balloons, injectors, forceps, anchors,
drug applicators, samplers, biopsy samplers, an electrode or
electrodes, suction tubes, temperature sensors, optical sensors, pH
meters, and others. Accordingly, the proboscises 214A and 214B may
be adapted to perform any one or more of a wide variety of
functions. For example, the extendable proboscises 214A and 214B
may be adapted to perform any of the following functions or
procedures: tissue cutting, tissue welding, suturing, cauterizing,
ablating, clamping, biopsy and tissue sampling, optical sensing,
chemical sensing, application of substance, injection of
substances, imaging, and temperature sensing. However, it should be
noted that the extendable proboscis 214A and 214B of an embodiment
of the present invention may not be limited to such functions or
procedures, and that the extendable proboscises 214A and 214B of an
embodiment of the present invention may be designed to perform a
wide variety of in vivo functions or procedures. Not necessarily
all of these functions and procedures and the corresponding designs
will be discussed herein. Proboscises 214A and 214B may also
perform functions such as moving or propelling the device 200, or
holding the device 200 in one place.
[0046] The device 200 may include, for example, one or more storage
tanks 210A and 210B. The extendable elements or proboscises 214A
and 214B may be operatively connected to, or may be able to
manipulate storage tanks 210A and 210B or substances within storage
tanks 210A and 210B The storage tanks 210A and 210B may be adapted
to store substances, liquids or gasses (e.g. adhesive substances,
medication, water, in-vivo samples, etc.) to be applied to area
inside a patient's body or collected from a patient The substances,
liquids or gasses stored in the storage tanks 210A and 210B may be
applied to or onto an area inside the patient's body, for example
through or by the proboscis 214A and 214B, which may be suitably
configured with a channel or tube, or may be attached to or move a
channel, tube, hose or lumen. The storage tanks 210A and 210B may
also be adapted to store samples collected from within the
patient's body (e.g. gas samples, blood samples, tissue samples,
etc.). For example, one or more of the proboscis 214A and 214B may
be adapted to collected gas samples, blood samples, tissue samples,
or the like and the samples may be transferred to one or more of
the storage tanks 210A and 210B, for storage.. In such case, the
proboscis 214A and 214B may be hollow, or may include a lumen, vias
or tubes internally or externally. For example, a pump 270 (FIG.
1C) may be used to provide suction and transfer materials to a
tank, and lumen 310 (FIGS. 2A and 2B) may transport materials
According to an embodiment of the present invention, the stored
samples may be analyzed within the housing 201 and the analyzed
data may be transmitted outside the patient's body. The stored
samples may also be retrieved and taken for analysis outside the
patient's body. In an alternate embodiment, a lumen or channel need
not be included, and the extendable elements may be substantially
solid.
[0047] FIG. 1C is a cutaway view of a device including one or more
moveable elements, arms or proboscises and one or more storage
tanks. For clarity, components of device 200 shown elsewhere are
not shown in FIG. 1C. Referring to FIG. 1C, device 200 includes a
proboscis 214 which includes a typically internal channel, lumen or
hose 205. One or more tanks 210a, 210b and 210c may provide or
collect fluid or other substances (e.g., medicine, bodily fluid)
via tubes or pipes 274 and pump 270. In various embodiments, pump
270 may be operated to empty or fill tank(s) 210, or to both empty
and fill tank(s) 210, as the application requires. Valves 272a,
272b and 272c may be provided to open,. close, and control the flow
to/from, the tank(s) 210. Proboscis 214 may be connected to, inter
alia, the pump 270. Pump 270, valves 272a, 272b and 272c, and other
components typically operate under the control of a controller such
as controller 212 (FIG. 1B).
[0048] Reference is made now to FIG. 2A, which is front view of a
moveable element, arm or proboscis, in accordance with an
embodiment of the present invention; and in addition reference is
also made to FIG. 2B, which is a side-sectional view of a moveable
element, arm or proboscis, in accordance with an embodiment of the
present invention. As discussed above, embodiments of the proboscis
300 may be attached to or included within ari in-vivo device, such
as devices 100 or 200. Embodiments of the proboscis 300 may be used
with other devices, such as devices having non-medical
applications. The proboscis 300 may include a proboscis body 302.
The proboscis 300 may further include any other suitable elements.
For example the proboscis 300 may include control elements such as
wires 304 (specified as 304A, 304B, 304C, and 304D in FIG. 2A, but
not specified for clarity in FIG. 2B), a flexible sleeve, coatings,
etc. Proboscis 300 may include, for example, a lumen or inner
cavity 310. While wires and other components are shown having a
certain shape, configuration, position, and number, other suitable
shapes, configurations, positions, and numbers may be used. For
example, wires 304A, 304B, 304C, and 304D may be substantially
circular in cross section, may be flat or ribbon like, etc.
[0049] The proboscis body 302 may be designed in accordance with or
to be integrated with in-vivo medical instruments, including but
not limited to graspers, blades, clamps, tissue collecting baskets,
scalpels, stents, catheters, suturing devices, forceps, dilatation
balloons, injectors, forceps, anchors, drug applicators, samplers,
biopsy samplers, an electrode or electrodes, suction tubes,
temperature sensors, optical sensors, pH meters, and others.
[0050] For example, a proboscis 300 may be designed to mimic or
perform the functionality of a scalpel. Such a scalpel proboscis
moveable element, or arm may have a sharp edge at, for example, its
distal end, suitable for cutting tissue. Another embodiment of a
proboscis 300 may include an injector. The injector proboscis may
be substantially hollow, such that the proboscis may be suitable
for injecting material into a site of interest Accordingly, the
proboscis 300, either individually or cooperatively with additional
one or more proboscis 300 or other instruments, may be adapted to
perform any one or more of a variety of functions.
[0051] According to some embodiments of the present invention the
proboscis body 302 may be a flexible, elastic or non-elastic,
elongated solid rod or hollow tube. The specific design and the
properties of each proboscis body 302 may be selected to best suite
the intended purpose or function of the proboscis 300.. It should
be noted however, that a proboscis having a specific design may be
suitable for carrying out one or more functions, or for performing
more than one procedures. For example, an injector proboscis may
also be suitable for taking samples of body fluids such as, for
example, blood or GI tract fluids . Proboscis 300 is typically
biocompatible, and may for example, be made of biocompatible
material, such as, silicon or a suitable polymer or plastic.
According to some embodiments of the present invention, at least a
portion or portions of the proboscis body 302 may include a
movement device or actuator such as a piezo material. For example
the proboscis body 302 may include a plastic piezo material, such
as Poly Vinlidine Fluoride (PVDF). Other movement devices, motors
or actuators may be used. According to other embodiments of the
present invention, at least a portion or portions of the proboscis
body 302 may include shape memory material. For example the
proboscis body 302 may include a Nickel Titanium alloy (NiTi), also
known as NiTinol. A discussion of methods of manipulation and
control of the proboscis body 302 of these and other embodiments of
the present is included herein. Other movement methods may be used
with embodiments of the present invention; for example those
described in published U.S. application 2003/0069474 to Courvillon,
Jr.
[0052] According to some embodiments of the present invention the
proboscis 300 may further include one or more control wires or
conductors such as wires 304. While four wires are depicted in FIG.
2A and 2B, other suitable numbers of wires may be used. The wires
304 may be embedded into the proboscis body 302. Alternatively, the
wires may be coupled (e.g. using any suitable adhesive, or by
mechanical methods, or other suitable methods) to the outer surface
of the proboscis body 302. The wires may be mounted at different
spots; for example within the proboscis body 302 or within material
forming the proboscis 300. Optionally, the wires 304 may be
positioned along two or four orthogonal axis. The wires may be
conductive wires capable of conducting energy to the proboscis body
302. According to one embodiment, the wires 304 may be adapted to
conduct electricity According to another embodiment, the wires 304
may be heat conductive. In other embodiments of the present
invention, the wires may be omitted altogether; for example, the
proboscis body itself may be piezo conductive. The wires may be
operatively connected to one or more portions of the proboscis body
302. According to some embodiments the proboscis body 302 may be
segmented or partially segmented and one or more wires may be
operatively connected to each one of the segments of the proboscis
body 302. For example, a set (where set may include one) of wires
or conductors may be connected to each segment. A set of wires may
traverse the proboscis starting at a proximal end, and at each
segment, a suitable set of wires may attach or connect electrically
to the segment, or to a portion of the segment that is a movement
device or actuator; such electrically connected wires typically do
not continue their traverse towards the distal end. According to
some embodiments of the present invention a set of two conductive
wires 304 may be coupled to each segment of the proboscis body
along an orthogonal axis. According to another embodiment of the
present invention a set of four conductive wires 304 may be coupled
to each segment of the proboscis body 302 along an orthogonal
axis.
[0053] In one embodiment, the set of control wires may include
subsets of control wires, each subset being attached to each
segment in a set of segments (wherein set and subset each can
include one item). Movement may be controlled in more than one
direction (such multi-directonal movement need not be controlled by
wires). For example, a subset of the control wires (for example
various wires in each subset being attached to different segments
or portions of the arm or extendible element) may control movement
in a first direction, and wherein a subset of the control wires
control movement in a second direction. For example, the first
direction may be an X direction and the second direction may be a Y
direction.
[0054] Referring to FIG. 2A, wires 304A, 304B, 304C, and 304D are
embedded at generally 90 degree intervals around a segment of
proboscis body 302. Typically, the cross section of the proboscis
body 302 is elliptical, but may have other shapes Wires 304A and
304C may be considered to be "tilt" or "vtilt" control wires and
wires 304B and 304D may be considered to be "pan" or "vpan" control
wires, however, these labels may be reversed if the viewer's
reference is different. Other numbers of control wires per section
may be used, and other numbers of possible control directions may
be used. The voltage sent along the wires 304 is typically under 20
volts, and the current is typically in the micro-ampere range,
although other current levels may be used. Each of wires 304A,
304B, 304C, and 304D may attach or connect electrically to a
segment, or to a portion of the segment that is a movement device
or actuator.
[0055] Numerous operational protocols or methods may be used for
the operation and control of a proboscis 300. The protocols may
take into consideration some or all of the characteristics of the
proboscis 300 and its operation and application. For example, the
following characteristics of the proboscis 300 may be considered:
the type of proboscis body 302, the length of the segments, the
type of wires 304, the energy used, the inclusion of shape memory
material in proboscis body 302, the inclusion of piezo material in
the proboscis body 302 and/or other characteristics. The protocol
may determine one or more of parameters of operation of the
proboscis 300. For example the protocol may determine the following
operation parameters: the amount of energy to be applied, the
duration of each period of energy application, the polarity of the
energy (e.g. when the energy is electricity) the vector of the
force to be applied, which segments are to be energized, the
desired level of deformation. Other parameters may also be
included. For example, in case the proboscis body 302 includes
shape memory material, it may be necessary to continue energizing
the deformed segments in order to maintain the deformation of those
segments. The parameters may be processed and an operation protocol
may be devised. The operation protocol may be included in or
effective by a controller. For example, controller 212, transceiver
206, controller 124 or an external controller may create
appropriate signals or control commands to be sent to wires or
other signal transmission devices attached to a proboscis, which
may cause various segments or movement control devices on the
proboscis to move appropriately. The controller may be adapted to
control and to interface the operation of the proboscis 300 in
accordance with the operation protocol. Accordingly, a proboscis
300 may be for example omni-directionally directed or
controlled.
[0056] According to some embodiments of the present invention an
electrical current may be applied to one or more wires 304
connected to one or more segments of a proboscis body 302
including, for example, PVDF, or other suitable material thereby
causing those segments to deform or bend
[0057] According to other embodiments of the present invention heat
may be applied to one or more segments of a proboscis body 302
including, for example, NiTinol or other suitable material through
heat conducting wires 304 embedded therein, thereby causing those
segments to deform or bend.
[0058] According to further embodiments of the present invention,
physical forces may be applied either directly or indirectly to
segments of a flexible proboscis body 302 using for example, motors
including, but not limited to mechanical, electrical, magnetic or
chemical motors, and any combination thereof, thereby causing the
proboscis body to deform or bend. The forces may be applied to, for
example, one or more wires 304 connected to one or more segments of
the proboscis body 302 and the wires may pull one or more segments
of the proboscis body, thereby causing those segments to bend or
deform.
[0059] Reference is made now to FIG. 3, which is a side-sectional
view (with a cut-away section) of a proboscis, arm, or moveable
element operated in accordance with an embodiment of the present
invention. In proboscis 400 the distal portion of the proboscis
body 402 may be segmented into, for example, three autonomous
segments 402A, 402B, 402C. Other numbers of segments may be used.
Each of the segments 402A, 402B and 402C may include one or more
movement device or actuators, for example, piezo material areas or
sections 402A', 402B' and 402C', including material such as PVDF,
that, for example, may be preprogrammed or manufactured to undergo
conformational changes when an electrical current is applied to the
material. For example the piezo material such as piezo material
areas or sections 402A', 402B' and 402C' may be programmed to
increasingly deform from a pre-programmed configuration (e g.,
coiled, straight, bent or other shape) in response to an increase
in the current level applied thereto Alternately, piezo material
may be programmed to deform in one direction when applied with a
first current, and deform in an opposite direction when applied
with a second current having an inverse polarity. Electricity
conductive wires 410, 411, 412, 413, 414 and 415 may be embedded
into or attached to segments 402A, 402B and 402C and embedded into
attached to a movement device, region or actuator such as piezo
material areas or sections 402A', 402B' and 402C'. Wires 410, 411,
412, 413, 414 and 415 may be embedded or attached at one or
suitable more points or continuously for each section; in FIG. 3
wires are connected at one point each. In the embodiment shown a
pair of wires 410, 411, 412, 413, 414 and 415 may be embedded
opposite to each other in each of the segments 402A, 402B and
402C
[0060] A first voltage may be applied by wire 414 and/or 415 to
segment 402C, thereby causing all or a portion of the piezo
material 402C' to react and segment 402C to deform upwards. A
second voltage may be applied by wire 412 and/or 413 to segment
402B, thereby causing all or part of piezo material 402B' to react
and segment 402B to deform downwards. Typically, the amount of
deformation depends on the amount of voltage and current and,
typically, the current is a constant DC current, although other
currents may be used. According to some embodiments of the present
invention, each of the segments 402A, 402B and 402C may return to
its original form (e.g., straight, coiled) when it is no longer
energized, thus it may be necessary to maintain the currents for as
long as deformation of the corresponding segments 402 is required.
The voltages or currents may be adjusted to deform the segments
402A, 402B and 402C in different directions or angles. In a typical
embodiment, additional wires and movement device or actuators (not
shown) may be embedded to move the segments 402 at an angle
perpendicular to the angle shown.
[0061] FIG. 4 depicts an alternate structure for an extendable
element according to an embodiment of the present invention FIG. 5
illustrates a cross sectional view of the extendable element of
FIG. 4, according to an embodiment of the invention. Referring to
FIG. 4 and FIG. 5, arm, proboscis or extendable element 500
includes movement devices, regions or actuators such as piezo
elements 510 controlled by electric current delivered by conductors
520 The extendable element 500 may include an inner shell 530, an
outer shell 535 (not depicted in FIG. 4 for the sake of clarity),
and possibly a lumen or inner space 540. The inner shell 530 and
outer shell 535 may be non-conductive, insulating, and may protect
the piezo elements 510 from, for example, external body fluids or
from substances flowing within the lumen 540. The inner shell 530
and outer shell 535 may be flexible, but rigid enough to keep a
certain shape when piezo elements 510 are not active.
[0062] When current is applied via conductors 520 to piezo elements
510, extendable element 500 may move in a controlled manner. The
extendable element 500 may be stored as, for example, a spiral or
coil. The extendable element 500 may be pre-stressed so that, when
no current is applied, it is shaped as a spiral or coil. In one
embodiment, piezo element is a tube approximately 1 mm in diameter,
approximately 15-20 mm in length, and may be stored as a spiral
having an average diameter of approximately 3 mm. In one
embodiment, about 200 sets of four piezo elements are used (each
piezo element spaced at a 90 degree interval around the extendable
element, as depicted in FIG. 5), and each piezo element typically
extends approximately 100 microns along the length of the
extendable element and provides approximately 5 degrees of
curvature, when fully activated. Different dimensions and different
numbers of piezo elements or other suitable movement devices,
regions or actuators may be used.
[0063] FIG. 6 illustrates a piezo element of the extendable element
of FIG. 4, according to an embodiment of the invention. Other
suitable piezo elements, having other suitable structures may be
used, and other suitable movement devices, regions or actuators may
be used. Referring to FIG. 6, piezo element 510 may include a first
piezo material 512, an inner conductive layer 514 (which may
include, for example, metal foil, conductive polymer, or other
suitable material), and a second piezo material 514. Positive,
conductor 520A may be connected to first piezo material 512,
negative conductor 520C may be connected to second piezo material
516, and central conductor 520B may be connected to inner
conductive layer 514, to provide a circuit for conductors 520A and
520C
[0064] In operation, when positive voltage is applied to positive
conductor 520A and first piezo material 512, the first piezo
material 512 expands When negative voltage is applied to negative
conductor 520C and second piezo material 512, the second piezo
material 512 contracts. As a result of current being applied to
conductors 520A and 520C, the piezo element 510 bends, creating a
radius of curvature. This operation may be similar to an operation
which is described in, for example, "Electroactive Polymer
Actuators as Artificial Muscles," Y. Bar-Cohen, Ed., Spie Press,
2001, incorporated herein by reference in its entirety.
[0065] The conductors 520 are typically connected to a controller,
such as discussed elsewhere herein. By proper activation of certain
piezo elements 510, the shape and motion of the extendable element
500 may be controlled.
[0066] In alternate embodiments other numbers and arrangements of
piezo elements and control elements may be used. Other structures
may be used; for example, inner and outer shell elements need not
be used or may be of different construction, and the extendable
element may have a different cross section (e.g., oval,
substantially rectangular, etc.).
[0067] Referring to FIG. 7, there is shown a device such as a
capsule with two proboscises. Device 200 includes a dome or cover
216, an imager 220, and one or more illumination devices 218. The
proboscises 214A and 214B may, for example, manipulate objects in
the filed of view of the imager.
[0068] Device 200 may achieve greater maneuverability and control
by, for example, using one or more proboscis arms to move, hold or
propel the device 200, for example, by pushing the device against
lumen walls or other structures, grasping lumen walls or other
structures, or by propelling the device in fluid. The proboscises
may, for example, act as an arm to perform a variety of tasks
and/or may be used as a leg to propel the device; as discussed
above tools or other devices may be attached to or part of the
proboscis Graspers may be included at the end of such proboscises
to aid motility.
[0069] Those with ordinary skill in the art may appreciate that
other embodiments of the present invention may enable a controlled
omni-directional deformation of the proboscis. It may thus be
possible to attach an instrument or sensor, for example an image
sensor, to the tip of the proboscis body, and the proboscis can be
deflected, for example, to enable a view of lateral and rear
areas
[0070] It will be appreciated by those skilled in the art that
while the invention has been described with respect to a limited
number of embodiments, many variations, modifications and other
applications of the invention may be made which are within the
scope and spirit of the invention.
* * * * *