U.S. patent application number 10/517858 was filed with the patent office on 2005-11-10 for gastroretentive drug delivery system comprising an extruded hydratable polymer.
This patent application is currently assigned to Euro-Celtique, S.A.. Invention is credited to Mohammad, Hassan.
Application Number | 20050249798 10/517858 |
Document ID | / |
Family ID | 9938815 |
Filed Date | 2005-11-10 |
United States Patent
Application |
20050249798 |
Kind Code |
A1 |
Mohammad, Hassan |
November 10, 2005 |
Gastroretentive drug delivery system comprising an extruded
hydratable polymer
Abstract
According to the present invention there is provided a
pharmaceutical product for retention in the stomach. The product is
produced by extrusion. The use of extrusion enables the product to
take many useful forms. The product may comprise a sheet of
hydratable polymer, the hydrated sheet being of a size which will
not pass out of the stomach, for example a shaped sheet or a roll.
The product may also comprise a sealed hollow tubular extrudate,
for example a tube sealed at both ends. The product may comprise a
filled capsule.
Inventors: |
Mohammad, Hassan;
(Cambridgeshire, GB) |
Correspondence
Address: |
DAVIDSON, DAVIDSON & KAPPEL, LLC
485 SEVENTH AVENUE, 14TH FLOOR
NEW YORK
NY
10018
US
|
Assignee: |
Euro-Celtique, S.A.
122 Boulevard de la Petrusse
Luxembourg
LU
L-2330
|
Family ID: |
9938815 |
Appl. No.: |
10/517858 |
Filed: |
December 14, 2004 |
PCT Filed: |
June 18, 2003 |
PCT NO: |
PCT/GB03/02622 |
Current U.S.
Class: |
424/451 |
Current CPC
Class: |
A61P 31/04 20180101;
A61K 9/0065 20130101; A61K 9/4808 20130101 |
Class at
Publication: |
424/451 |
International
Class: |
A61K 009/48 |
Foreign Application Data
Date |
Code |
Application Number |
Jun 18, 2002 |
GB |
0214013.5 |
Claims
1. An extruded pharmaceutical product for retention in the
stomach.
2. An extruded pharmaceutical product according to claim 1,
comprising a sheet of hydratable polymer, the hydrated sheet being
of a size which will not pass out of the stomach.
3. An extruded pharmaceutical product according to claim 2, wherein
the sheet is extruded as a shaped sheet.
4. An extruded pharmaceutical product according to claim 3, wherein
the sheet takes the form of a roll.
5. An extruded pharmaceutical product according to claim 2, wherein
the sheet is extruded as a planar sheet and is folded or otherwise
compacted.
6. An extruded pharmaceutical product according to claim 1,
comprising a sealed hollow tubular extrudate.
7. An extruded pharmaceutical product according to claim 6
comprising a tube sealed at both ends.
8. An extruded pharmaceutical product according to claim 2,
comprising a filled capsule.
Description
[0001] More particularly, the present invention relates
pharmaceutical products which are retained in the stomach. In an
associated aspect, the invention is concerned with a controlled
release drug delivery system for prolonged gastric residence.
BACKGROUND OF THE INVENTION
[0002] Although oral sustained release drug delivery systems have
attracted considerable attention for the last forty years,
technologies for prolongation of gastric residence time of drugs
are reasonably recent. Gastric emptying can vary from less than an
hour to more than six hours between different subjects and within
the same subject. In addition, there is considerable variation in
drug absorption from site to site within the gastrointestinal
tract. These two aspects can adversely affect the level of
bioavailability and the degree of prolongation of an effective
plasma level achievable by a conventional sustained release dosage
form. Prolongation of residence in the stomach of a dosage form
system with sustained drug release properties can have a
significant enhancing effect on bioavailability and hence drug
effectiveness. Drug being slowly and continuously released at a
predetermined rate in the stomach can reach the absorption site in
the small intestine in an absorbable state, i.e as a solution or
fine dispersion.
[0003] During the last 15 years, technologies such as swelling
polymers, bioadhesive polymers and inflatable devices in either
single or multi-unit systems have been actively investigated.
Although drug retention and drug release tested in vitro from most
oral prolonged residence delivery systems can be foreseen and
maintained between reasonable limits, the lack of in vivo
correlation has been evident.
[0004] Physiological factors such as pH and motility of the stomach
and the fasted and fed state of the subjects have been found to
have a profound effect on the gastric residence time of drug
delivery systems. Since the stomach is rarely considered a site of
drug absorption, most, if not all, sustained release dosage forms
have been designed to release the drug through the gastrointestinal
tract.
[0005] A recent study suggested that the microorganism Helicobacter
pylori is a major factor in the development of gastric ulcer. It
has also been found that about 60% and 40% of the Helicobacter
pylori are embedded in the fundus and the body regions of the
stomach, respectively. For an efficient treatment, a sustained
site-specific release of antibiotic to the gastric mucosa is
advantageous.
[0006] The natural function of the stomach is to temporarily store,
mechanically break down and disrupt by acid (hydrochloric acid
secreted by parietal cells) and enzyme (pepsinogen secreted by
chief cells and converted by the gastric acid into pepsin) the
chemical bonds associate with ingested food. The stomach is a
hollow elastic organ which varies in shape and size between
individuals and in a single individual, depending on size and type
of ingested meal.
[0007] Anatomically, the stomach may be divided into four main
regions:
[0008] i) Cardia: the smallest part of the stomach and within 3 cm
of the junction with the esophagus. The cardia is rich in mucus
glands whose secretion is necessary to protect the esophagus from
the acid and enzymes of the stomach.
[0009] ii) Fundus: the upper part of the stomach superior to the
junction between the stomach body and the esophagus.
[0010] iii) Body: the largest part of the stomach, responsible for
mixing of ingested food and secretion gastrin.
[0011] iv) Pylorus: the lower curved part of the stomach which
connects the body with the pyloric canal which empties the stomach
content into the duodenum. The pyloric glands are mostly involved
in the secretion of mucus.
[0012] The stomach activity can be divided into three phases:
[0013] v) The cephalic phase in which the secretion of gastric
fluids such as acids, enzymes and salts, and the motility of the
digestive system is stimulated by seeing, smelling, tasting of or
even thinking about food.
[0014] vi) The gastric phase, which is a continuity of the previous
phase and is promoted with the arrival of food to the stomach. The
gastric phase is associated with stomach stress and increase in the
secretion of hydrochloric acid and enzymes. In fasting subjects,
the stomach pH may be as low as 1.5. Food ingestion (particularly
milk) will initially neutralize the stomach content to as high as
pH 6.0, (7) during which the saliva amylase continues acting on the
carbohydrate. The presence of food in the stomach triggers further
secretion of hydrochloric acid, which can continue for up to two
hours. Low pH of the stomach content will inhibit the amylase
activity to create a new environment for pepsin activity.
[0015] vii) The intestinal phase which is usually initiates a few
hours after the arrival of food and when the first chyme is
delivered to the duodenum. The arrival of the chyme to the
intestine triggers new sets of hormones, enzymes and buffers that
coordinate the activities.
[0016] There are several basic principles by which drug from an
oral solid dosage form can be delivered to the stomach for either
local or systemic absorption. Each principle has its own advantages
and limitations. Amongst these technologies are:
[0017] 1. Swelling and Expanding Systems.
[0018] Dosage forms that swell and change their density in relation
to their surrounding, gastric content, can be retained in the
stomach content for longer than other conventional dosage forms. In
the first instance, the device may sink down in the gastric content
and then, by physically changing, may acquire low density and
thereby float to the surface. A monolithic device comprising of
drug and swelling agent may absorb water and swell to form a soft
gelatinous outside surface and float on the surface whilst
maintaining its integrity for a pre-determined time. Hydration and
swelling alone would not be enough to significantly change the
device density. Hence addition of a small amount of fatty material
may be necessary to impede wetting and improve floating (4). The
level and type of the swelling agent and the fatty substances have
a significant effect on the final swelling and floating
characteristics of the device. Swelling also significantly
increases the dosage form size, which has been found to influence
the transit properties. The stomach discharges its contents
including the non-disintegrated solid dosage form, through the
pylorus into the intestine.
[0019] A non-disintegrating solid dosage form of a manageable size
for swallowing may freely pass the pylorus. A solid dosage form
that can swell fairly quickly in the gastric contents can be
retained in the stomach until the size is reduced, for example, by
erosion. Such enlarged dosage forms should not block the pylorus
and the size reduction should be gradual to prolong its residency.
The premature gastric emptying of the dosage form could lead to
swelling and obstruction of the duodenum.
[0020] There are several contradictory reports on the effect of
dosage form size on residency. A definite cut-off size of a dosage
form for appropriate gastric retention is very difficult to specify
due to fasted, fed and individual variations (5,6).
[0021] The most common approach to this type of technology is to
encapsulate a core containing drug and swelling agent. Such agents
can expand 2-50 fold (7) when gastric fluid permeates through the
coat. When all the soluble content is released the device collapses
and discharges through the pylorus.
[0022] Another approach is a solid dosage form containing drug,
swelling agent and one or more erodible polymers such as high
viscosity Hydroxy propylmethy cellulose and the acid soluble
Eudragit E. In the gastric media the device swollen to a larger
size that can not pass through the pylorus until the size is
reduced by erosion. The gastric residence time can be prolonged as
long as food and water are maintained in the stomach.
[0023] The technology has attracted many academic and commercial
organisations but so far has failed to be developed into more than
one product (8). Intra- and inter-variation between individuals and
the difficulty of maintaining the fed state are obstacles which
need to be overcome to allow further progression of this
technology.
[0024] A folded sheet dosage form to increase time residency was a
subject of an early patent (24) for veterinary use. Initially the
drug is loaded into a water-insoluble diffusable polymer and cast
into a thin sheet. The sheet is then manually rolled and fed to the
animal either directly or after encapsulation (24). In the stomach
the folded sheet reopens to its original size and shape. The opened
sheet should be large enough so as not to pass the pyloric
sphincter.
[0025] Several human studies on the transit of non-disintegrated
solid dosage form have shown that the pyloric sphincter can only
pass solid object smaller than 8 mm. A similar study has carried
out using a non-disintegrating polyethylene geometrical shape (20
mm tetrahedron) spiked with a radioactive marker. The device showed
a median retention time of 6.5 hour in fed subjects but a less
significant 3 hours median time in fasted subjects (25).
[0026] In an animal study, non-disintegrating capsule shaped
tablets (22.0.times.8.5.times.5.1 mm) were retained in the pig
stomach for up to 6.0 hours. In contrast, fine powder and solution
was transported out of the stomach in a very fast manner (26).
[0027] Therefore, a fully opened rectangular sheet, 10 mm.sup.2 or
larger in area, should not practically pass the pyloric sphincter
unless fragmented or collapsed. The acidic environment and the
presence of gastric enzymes could also play a major role in the
distruption and elimination of the sheet after a predetermined time
of residency. The limitations of this technology are the
reproducible cutting, folding, maintaining the shape and filling
the folded sheet into capsule shells.
[0028] 2. Floating and Buoyancing System.
[0029] The basic principle of this system is to trap gases within
sealed encapsulated cores that can float over the gastric content
and so be retained in the stomach for a longer time (9-12). Due to
the buoyancy effect, this system can provide a protective layer
preventing the reflux of gastric content into the esophageal region
and can also be used for controlled release devices.
[0030] The development of this system is based on two main
techniques. The first system is made of hollow cores containing
drug and coated with protective membrane. The trapped air in the
cores will help the system to float on the gastric content until
all or most of the soluble ingredients are released and the system
collapses.
[0031] The second system is made of cores that, in addition to the
drug, contain chemical substances, which generate gases when
activated. Coated cores, for example, containing carbonate and/or
bicarbonate generate carbon dioxide in the reaction with the
hydrochloric acid in the stomach or incorporated organic acid in
the system. The generated and trapped carbon dioxide within the
encapsulated core help in floating the device. The inflated device
later collapses and clears from the stomach when the generated gas
permeates slowly through the protective coat.
[0032] The major setbacks of these technologies are the different
level of hydration and swelling of the agents under different
stomach condition. The gastric pH and presence of water and foods
have an unpredictable effect on the swelling agents. The time
required for swelling and deflation and/or erosion dictate the
successfulness of the system and the gastric residence time. Delay
in the swelling or fast deflation or erosion will cause early
transit of the device to the duodenum.
[0033] It is well observed and documented that presence of food and
water in the stomach has a significant effect on the residency of
non-floating and floating devices (12-14). A human study of the
retention time of floating capsules and tablet devices showed that
the devices may be retained for up to 4 hours in fed subjects
compared to only 2 hours in fasted subjects (15). Other factors
affecting the hydration speed and degree will inevitably change the
residence time of the floating dosage form. Film forming polymer
should be carefully selected to fulfil specific needs. Film
hydration and permeability are two more important factors to be
carefully considered. These publications recommend that the film
should easily permit water and chloride ion (if it is needed for
gas evolution), have good elasticity, and release the drug whilst
retaining the evolved gas for a considerable time.
[0034] In general the effectiveness of the floating system is
determined by the subjects conditions (fast and fed), presence of
water and the body state (position) the housekeeper waves (in phase
3 of the interdigestive migrating myoelectric complex, IMMC, which
occurs every 1-2 hours (8)), and the device properties, such as
size, density, inflation mechanism and other formulation
factors.
[0035] 3. Bioadhesive System.
[0036] Intensive studies have been carried out since this approach
was first published by Park and Robinson in 1984 (16), on a wide
range of natural and synthetic polymers for their bioadhesive
properties. Anionic polymers such as sodium carboxy methyl
cellulose has a better bioadhesive properties than the neutral and
cationic polymers. This finding was disputed later when other
cationic polymers were successfully tested (17). Bioadhesive
polymers can provide a good vehicle for delivery of drugs to a
number of mucosal surfaces in addition to the gastric mucosa. The
system can be designed by incorporation of the drug and other
excepients within the bioadhesive polymers. On swallowing, the
polymer hydrates and adheres to the mucus membrane of the stomach.
The mechanism of the adhesion is thought to be through the
formation of electrostatic and hydrogen bonding at the
polymer-mucus boundary.
[0037] A group of researchers (18) have applied the commercially
available sucralfate (an aluminum salt of disaccharide used in
healing duodenal and gastric ulcer) as a bioadhesive polymer. For a
gastric retention system in combination with high viscosity
methocel, the compressed tablet was found to adhere to a glass
surface and remained intact for at least 24 hours in a 0.1N
hydrochloric acid. In this media the sucralfate react with
hydrochloric acid to form a very tacky gel. It is believed that
sucralfate exerts its healing action not by neutralising the excess
acid but by mechanically adhering to the proteinaceous exudate at
the ulcer site.
[0038] Ideally the muco-adhesive polymer should adhere to the
gastric mucus layer until it is removed spontaneously from the
surface by various physiological factors. The differences in the
physico-chemical nature of these polymers and the variation of
inter and intra individual physiological factors such as
peristalsis and mucin turnover rate, gastric pH and fast/fed state
and type of foods make prediction of removal difficult.
[0039] Although there is a substantial amount of literature
relating to the gastroadhesive properties of a wide range of
polymeric materials, the appropriate successful candidate has yet
to be found. Proper selection and evaluation of a successful
gastroadhesive polymer involves developing several in vitro and in
vivo reproducible methods to quantify the interaction between the
polymer and mucosal surface under different extreme conditions. All
factors directly and indirectly effecting the adhesion properties
should be carefully and intensively studied.
[0040] Carbopol and polycabophil were reported to have excellent
mucoadhesive properties when tested in animals. Despite these
animal successes, test in humans have shown rather disappointing
results. Although, there is about a 3 hour delay in gastric
emptying in fasted state of animals, there is only 1-1.5 hour delay
in fasting humans (19, 20). In spite of the excellent bioadhesive
properties of polycarbophole and carbopol through numerous hydrogen
bonds provided by the carboxyl group, the disappointing results are
believed to be due to the fast turnover of gastric mucin in
man.
[0041] 4. Ion Exchange Resin.
[0042] In a published study (21), fast dissolving freeze dried
tablets containing an anionic ion-exchange resin (Duolite AP-143)
revealed prolonged gastric residence and uniform distribution of
the resin within the stomach regardless their particle size
distribution. The ion-exchange resin, unlike the water soluble
non-absorbable marker diethylenetriaminepenta-acetic acid
co-administered with the resin was retained in the stomach for up
to 5 hours. It has been suggested that the ion-exchange resin
contained in the dosage form may have inherent bioadhesive
properties similar to highly charged polymers. As only one in vivo
study was carried out, further in vitro and in vivo studies under
different physical and physiological condition are required to
justify whether the anionic exchange-resin is a suitable candidate
as gastroadhesive agent.
[0043] In another human study (10, 11), radio labeled ion-exchange
resin loaded with bicarbonate ions and coated with ethyl cellulose
resided in the stomach significantly longer than non loaded
ion-exchange resin treated in the same way. In the stomach,
chloride ions readily exchange the bicarbonate ions to generate
carbon dioxide. The released carbon dioxide inflates the coated
membrane, helping the resin to float. The resin keeps floating
while there are bicarbonate ions available and ready to exchange
with the chlorine ions in the stomach. Prolonging the gastric
residence by a floating system increases the chance of drug release
in the fundus and cardiac regions of the stomach for local use.
[0044] 5. Magnetically Controlled Gastric Residence.
[0045] A bilayer tablet comprising of a drug layer made of drug,
hydroxypropylmethylcellulose, HPMC, and lactose and a magnetic
layer made of ultra fine ferrite and HPMC has been developed. Each
layer was separately compressed into tablets. The compressed
magnetic layer was then coated with water insoluble ethyl-vinyl
acetate copolymer. After drying, the coated magnetic layer was
stuck to the drug layer with cyanoacrylate-type adhesive.
[0046] An in vivo animal study was performed comparing orally
administered single layer tablets (drug only layer without the
magnetic layer) with bilayer tablets (both the drug and the
magnetic layers). To increase the gastric residency time, a
magnetic field of 1000-2600 G was applied. The gastric residency
and the drug bioavailability of the bilayer tablets were
significantly increased by the application of the magnetic
field.
[0047] In a series of studies, this concept was shown to work but
is rather difficult to undertake practically and realise a
commerically viable dosage form. Locating the exact position of the
magnetic field to the magnetic dosage form in the stomach for each
individual may be not easy. In addition, the safety of applying of
more than 1000-G magnetic field is unproven.
SUMMARY OF THE INVENTION
[0048] According to the present invention there is provided a
pharmaceutical product for retention in the stomach. The product is
produced by extrusion. The use of extrusion enables the product to
take many useful forms.
[0049] The technology is a versatile system which can be used to
deliver drugs in a sustained release manner for local and systemic
absorption. A specially designed pharmaceutical dosage form can be
provided, usually a solid of different distinctive shape and size
that can remain in the stomach for a predetermined time. During
residency in the stomach, drug is released from the system in a
sustained manner to provide medication for local and/or systemic
use.
[0050] A prolonged gastric residence system of this invention can
provide the following advantages;
[0051] 1. Delivery of drugs that act locally such as antacids,
enzymes and antibiotics for bacterially caused ulcers.
[0052] 2. Modified route for drugs that are degraded in the lower
part of the intestine which make it unsuitable for a conventional
CR formulation. Metoprolol is known to be well absorbed from the
large intestine but is also affected by high pre-systemic clearance
in the area (1).
[0053] 3. Improved bioavailability of drugs which (a) are poorly
soluble in the high pH environment of the intestine, or (b) have a
narrow absorption window.
[0054] 4. Drugs that are fairly soluble in the acidic media in the
stomach could remain in solution even after transit to the alkaline
region of the duodenum. Drugs delivered into the higher pH region
of the GIT in a sustained low concentration manner will remain in
solution or precipitate into a colloidal form regardless of their
solubility in the media. Maintaining the low solubility drug in
solution or in fine dispersion will have significant influence on
its absorption and bioavailability.
[0055] 5. Drugs that are absorbed from the proximal part of the
small intestine, such as nitrofurantoin, riboflavin, levodopa,
p-aminobenzoic acid and allopurinol (2, 3) are best administered in
a gastric retentive device to improve their bioavailability.
[0056] 6. Controlled release of drugs with site specific absorption
limitations. Drugs that are absorbed rapidly from the GIT, such as
amoxicillin are best released slowly in the stomach. These drugs
can be formulated into a retentive device to expand their
therapeutic window.
[0057] 7. Overall improved bioavailability of drugs by increasing
the total gastrointestinal retention time. The ability to retain
the dosage form within the stomach would provide a constant stream
of supply of the drug over a wider absorption area. This will
provide optimum conditions maximizing drug absorption.
[0058] 8. Effectively using antibiotics with less likelihood
disrupting the normal lower intestinal flora.
[0059] The treatment of local diseases associated with reflux
esophagitis, hiatus hernia and Helicobacter pylori infection could
benefit from a prolonged release floating system. This system
provides mechanical protection to the affected upper region of the
stomach in addition to a sustained drug release (i.e. antibiotic)
and/or continuous neutralisation of the excess acid. In a recent
study (22) it was reported that combined treatment of omeprazol
(prostaglandin analogues) 20 mg BD, amoxycillin (antibiotic) 500 mg
td, and metronidazole (anti-microbial against anaerobic bacteria)
400 mg td is more effective in eradication of Helicobacter pylori
and relief of symptoms of non-ulcer dyspepsia than omeprazol alone.
The high dose of amoxylilin and metronidazole is required for their
systemic rather than local action. The drug transit through the
stomach is reported to be about 1 hour. Retention with sustained
drug release in the stomach will benefit local action and hence,
reduction in the total dose required.
[0060] In addition it has been demonstrated (23) that, in 60% of
Helicobacter pylori sufferers, the organism was found in the fundal
region of the stomach, in 45% in the body and in 14% in the gastric
antrum (32% having the microorganism in more than one region of the
stomach). Therefore, for the majority of sufferers, the
Helicobacter pylori is in the upper region of the stomach. The
floating sustained release device not only provides the drug for
local use but also provides the drug where it is needed.
[0061] In one embodiment, the product of this invention comprises a
sheet of hydratable polymer, the hydrated sheet being of a size
which will not pass out of the stomach. Typically the hydrated
sheet is at least 8 mm by 8 mm, perhaps at least 12 mm by 12 mm.
The sheet is made by extrusion of a mix of active ingredient and
polymer, along with other optional ingredients. The mix is
preferably extruded as a shaped sheet, and for example takes the
form of a roll. As it is extruded, the roll is cut to size. The cut
roll may then be filled in a capsule. Upon swallowing, the capsule
dissolves and the roll rehydrates and unrolls. Other configurations
may be employed for the sheet of hydratable polymer, and for
example it can be a folded sheet, or otherwise compacted.
[0062] The sheets of this invention can be made by melt extrusion.
Redesigning only the extrusion mold can produce a pre-folded sheet
which can either be taken orally directly or after filling into
capsules. The opened flat sheet may benefits from both the size
enlargement, preventing it from passing through the pyloric
sphincter and from the non-disintegrating low density polymer which
should aid the floating of the devise. With a range of gel forming
polymers, each individual characteristic of buoyancy (high-density
differential) and size (larger than 8 mm) can be varied. The opened
sheet could combine both the large area and the floating
characteristics required for prolonging the residency time in the
stomach.
[0063] As mentioned earlier, the folded sheet could be filled into
capsules using a tablet filling mechanism. The folded sheet
dimensions could be varied from 5.0-9.0 mm diameter and 14.2-24.4
mm in length to either match the dimensions for direct delivery or
for filling into size 4-0 elongated capsules.
[0064] A preferred system comprises of a single folded sheet opened
flat upon hydration by the gastric media. The medium to low density
polymer and the geometrical size and shape of the sheet grants
prolonged residency in the stomach. The presence of water and food
in the stomach could be a vital factor in maintaining the buoyancy
of both systems necessary for preventing an early transit of the
system out of the stomach. The sheet may include acid or enzyme
degradable materials, for example polymers, which will eventually
be digested and thus change the physica structure, for example by
fragmentation of the sheet, and make it susceptible for evacuation
with the stomach contents.
[0065] In another embodiment, the product of this invention
comprises a sealed hollow tubular extrudate. A mix of suitable
ingredients including the active ingredient is extruded as a tube,
and is cut when still pliable to seal the cut ends, resulting in a
hollow particle with active ingredient in the walls. The specific
gravity of the particle is such that it floats on gastric juices,
and gradually releases the active agent.
[0066] This product can be made by melt extrusion. The melt
extrusion head can simply be modified to extrude hollow tubes
rather than solid strand. These tubes can be made with different
inner and outer diameters and can also be cut to any predetermined
lengths.
[0067] The method of executing cutting while the extrudates (solid
strands or hollow tubes) are hot and flexible is called surface
cutting. The cutting blades are mounted on the die plate to provide
an immediate cut that blinds the cutting edge of the tube while it
is still in a semi-melted condition. The produced hollow extrudate
tubes provides a low density product with significant buoyancy
power. In this dosage form the drug can either be loaded in the
tube wall within the protective modified release polymer or can be
loosely packed within the tube void using a second single screw
extruder mounted on the side of the extrusion head. It is believed
that the hollow tube extrudates with two sealed ends will remain
buoyant over the stomach contents until the differential density
between the dosage form and the content is diminished. This will
occur after the drug and other water-soluble components are
released from the dosage form. This elimination from the tube wall
will create pores allowing water penetration into the tube voids.
This will balance the density differential and hence the
multiparticulates sink down and are transported with other gastric
contents.
[0068] Hollow tubes can be heat sealed at both ends. The trapped
air within the void provides floating properties to the device. The
final density of the proposed solid dosage form will be much lower
than the gastric contents. Low glass transition Tg polymers with or
without plasticizer (eg: Eudragit RSPO, ethyl cellulose, polyvinyl
acetate phthalate and other) can be loaded with the drug and
extruded as a hollow tubes. Pelletisation by surface cutting will
boost sealing of the two ends of the tubes.
[0069] A multi-unit floating device loaded with antibiotic and an
acid neutralization capacity can be designed for gastric ulcer
treatment caused by Helicobacter pylori.
REFERENCES
[0070] 1. Warrington S J Barclay S P, Jo vV A, Shotton P A, Wardle
H M, Good W. 1985 Br. Jour. Clin. Pharmc. 19, 219S.
[0071] 2. Ichikawa M., Watnabe s., and Miyake Y. 1991 J. Pharm.
Sci. Vol. 80, No.11, 1062-1066
[0072] 3. Ichikawa M., Kato T., Kawahara M., Watanabe S., and
Kayano, M. 1991 J. Pharm. Sci. 80, 1153
[0073] 4. Oth M., Franz M., Timmermans J., and Moes A., 1992 Pharm.
Res. 9, 298.
[0074] 5. Meyer J H., Dressman J., Fink, A., and Amidon G. 1985
Gastroenterology, 89, 805.
[0075] 6. Khosla R., Feely L C., and Davis S S., 1989 Int. J. Pharm
53, 107.
[0076] 7. Deshpande A A., Rhodes C T., Shah N H., and Malick A W.,
1996 Drug Dev. Ind. Pharm. 22 (6) 531-539
[0077] 8. Hwang S J., Park H., and Park K., 1998 Therap. Drug
Carrier Syst. 15 (3), 243.
[0078] 9. Groning R., and Heun G., 1984 Drug Dev. Ind. Pharm. 10,
527.
[0079] 10. Atyabi F., Sharma H., Mohammad H A H., And Fell J T.,
1996 J. Cont. Drug Rel. 42, 25.
[0080] 11. Atyabi F., Sharma H., Mohammad H A H., And Fell J T.,
1996 J. Cont. Drug Rel. 42, 105.
[0081] 12. Ichikawa M., Watnabe S., and Miyake Y., 1991 J. Pharm.
Sci. 80, 1062.
[0082] 13. Khatar D., Ahuja A., and Khar R. K., 1990 Pharmazie 45,
356
[0083] 14. Mazer N., Abisch E., Gfeller J C., Laplanche R.,
Bauerfeind P., Cucala, M., Lukachich M., and Blum A. 1988. J. Phar.
Sci. 77, 647.
[0084] 15. Davis S S., 1986. STP Phar. Pratiques 2, 1015.
[0085] 16. Park K., and Robinson J R., 1984. Int. J. Pharm. 19,
107.
[0086] 17. Singla A K Et. Al. 1999 The 18.sup.th Pharmaceutical
Technology Conference. Page 397
[0087] 18. Li S P., Pendharkar C M., Mehta G N., Karth M G., and
Feld K M., 1993 Drug Dev. Ind. Pharm. 19 (19), 2519.
[0088] 19. Harris D., Fell J T., Sharma H L., and Taylor D C., 1990
J. Cont. Rel 12, 45
[0089] 20. Harris D., Fell J T., Sharma H L., and Taylor D C., 1990
J. Cont. Rel 12, 55
[0090] 21. Burton S Washington N., Steele R J C., Musson R., and
Feely L., J Phar. Pharm. 47, 901-906
[0091] 22. McColl K Et Al 1998, New Eng. J. med. 339, 1869
[0092] 23. Altherton J C., Balsitis M., Kirk G E., Hawkey C J., and
Spiller R C., Gut 36, 670.
[0093] 24. UK Patent 1 601 923 (Beecham Group Ltd) 1977
[0094] 25. Fix A., Cargill R., and Engle K. 1993 Pharma. Rese. Vol.
10 No.5 1087
[0095] 26. Davis s. s., Illum L. and Hinchcliffe 2001 Pharm.
Pharmaco. Vol.53, 33
ADDITIONAL REFERENCES
[0096] Agyilirah G A., Green M., duCret R., and Banker G S., 1991
Int. J. Pharm. 75, 241-247
[0097] Burns S. J., Corness D., Hay G., Higginbottom S., Whelan I.,
Attwood D., and Barnwell S G., 1995 Int. J. Pharm. 121, 37-44
[0098] Cargill R., Caldwell L J., Engle K., Fix J A., Porter P A.,
and Gardner C R., Pharm. Res. .5, .8, 533-536
[0099] Chueh H R., Zia H., And Rhodes C T., 1995 Drug Dev. Ind.
Phar. 21 (15) 1725-1747
[0100] Deshpande A A., Shah N H., Rhodes C T., and Malick W., 1997
Int. J. Pharm. 159, 255-258
[0101] Deshpande A A., Shah N H., Rhods C T., Malick W., Al. 1997
Pharm. Res. .14, .6, 815-819
[0102] Fujimori J., Macida Y., Tanaka S., and Nagai T., 1995 Inter.
J. Pharm. 119, 47-55
[0103] Dong L C,, 1999 Patent W09907342-A1
[0104] Iannuccelli V., Coppi G., bernabei M T., cameroni R., 1998
(part 1) Int. J. of Pharm. 174, 47-54
[0105] Iannuccelli V., Coppi G., bernabei M T., cameroni R., 1998.
(part 2) Int. J. of Pharm. 174, 55-62
[0106] Kawashima Y., Niwa T., Takeuchi H., Hino T., and Itoh Y.,
1992 J. Pharm. Scie. .81, .2, 135-140
[0107] Longer M A. 1985 J. Pharm. Scie. .74, .4, 406-410
[0108] Park K. and Robinson J. R. 1984 Inter. J. of Pharm. 19,
107-127
[0109] Timmermans J., and Moes A J., 1994 J. Pharm. Scie. .83, .1,
18-24
[0110] Whitehead L. Fell J T., Collet J H., Sharma H L., Smith A
M., 1998 J. Cont. Rel. 55, 3-12
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