U.S. patent application number 11/168172 was filed with the patent office on 2005-10-27 for occluding vasculature of a patient using embolic coil with improved platelet adhesion.
Invention is credited to Jones, Donald K., Mitelberg, Vladimir.
Application Number | 20050240216 11/168172 |
Document ID | / |
Family ID | 25376423 |
Filed Date | 2005-10-27 |
United States Patent
Application |
20050240216 |
Kind Code |
A1 |
Jones, Donald K. ; et
al. |
October 27, 2005 |
Occluding vasculature of a patient using embolic coil with improved
platelet adhesion
Abstract
A method as provided for occluding the vasculature of a patient.
The method comprises the steps of providing a plurality of embolic
coils having a textured surface. The embolic coils are introduced
into the patient's vasculature. In this manner, the textured
surface provides improved platelet adhesion compared to a
non-textured surface, to promote clotting. In the illustrative
embodiment, the embolic coil comprises a platinum-tungsten alloy
wire and the texturing is performed by abrasion or sandblasting to
provide substantially uniform roughness comprising pockets having
diameters of about 0.125 microns to about fifty microns and depths
of about 0.25 microns to about twenty microns.
Inventors: |
Jones, Donald K.;
(Lauderhill, FL) ; Mitelberg, Vladimir; (Aventura,
FL) |
Correspondence
Address: |
PHILIP S. JOHNSON
JOHNSON & JOHNSON
ONE JOHNSON & JOHNSON PLAZA
NEW BRUNSWICK
NJ
08933-7003
US
|
Family ID: |
25376423 |
Appl. No.: |
11/168172 |
Filed: |
June 28, 2005 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
|
|
11168172 |
Jun 28, 2005 |
|
|
|
09880506 |
Jun 13, 2001 |
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Current U.S.
Class: |
606/200 |
Current CPC
Class: |
A61L 31/14 20130101;
A61B 17/12113 20130101; A61L 31/022 20130101; A61B 17/12145
20130101; A61L 2430/36 20130101; A61F 2/0077 20130101; A61B
17/12022 20130101 |
Class at
Publication: |
606/200 |
International
Class: |
A61M 029/00 |
Claims
What is claimed is:
1. A method for occluding the vasculature of a patient, comprising
the steps of: providing a plurality of embolic coils having a
textured surface; introducing said plurality of embolic coils into
the patient's vasculature, whereby the textured surface provides
improved platelet adhesion compared to a non-textured surface, to
promote clotting.
2. A method as defined in claim 1, including the step of texturing
the surface of an embolic coil by abrasion.
3. A method as defined in claim 1, including the step of texturing
the surface of an embolic coil by sandblasting.
4. A method as defined in claim 1, in which said embolic coil
comprises a platinum-tungsten alloy wire.
5. A method as defined in claim 1, in which said embolic coil
includes a proximal portion and a distal portion; said proximal
portion being relatively smooth and said distal portion being
relatively textured.
6. A method as defined in claim 1, in which said embolic coil has
substantially uniform roughness comprises pockets having diameters
between about 0.125 microns and about 50 microns.
7. A method as defined in claim 6, in which said pockets have
depths of between about 0.25 microns and about 20 microns.
8. A method as defined in claim 1, in which the embolic coils are
used to embolize a vessel for vessel sacrifice.
9. A method as defined in claim 1, in which the embolic coils are
used to reduce or block blood flow to an arterial-venous
malformation or to a fistula.
10. A method as defined in claim 1, in which the embolic coils are
used to block blood flow to tumor.
11. A method for treating an aneurysm of a patient, comprising the
steps of: providing a plurality of embolic coils having a textured
surface; introducing said plurality of embolic coils into the
patient's aneurysm, whereby the textured surface provides improved
platelet adhesion compared to a non-textured surface, to promote
clotting.
12. A method as defined in claim including the step of texturing
the surface of an embolic coil by abrasion.
13. A method as defined in claim 11, including the step of
texturing the surface of an embolic coil by sandblasting.
14. A method as defined in claim 11, in which said embolic coil
comprises a platinum-tungsten alloy wire.
15. A method as defined in claim 11, in which said embolic coil
includes a proximal portion and a distal portion; said proximal
portion being relatively smooth and said distal portion being
relatively textured.
16. A method as defined in claim 11, in which said embolic coil has
substantially uniform roughness comprises pockets having diameters
between about 0.125 microns and about 50 microns.
17. A method as defined in claim 11, in which said pockets have
depths of between about 0.25 microns and about 20 microns.
18. A method for occluding the vasculature of a patient, comprising
the steps of: providing a plurality of embolic coils formed of a
platinum-tungsten alloy; texturizing the surface of said embolic
coils by abrasion or sandblasting; introducing said plurality of
textured embolic coils into the patient's vasculature, whereby the
textured surface provides improved platelet adhesion compared to a
non-textured surface, to promote clotting.
19. A method as defined in claim 18, in which said embolic coils
have substantially uniform roughness comprising pockets having
diameters of between about 0.125 microns and about 50 microns and
depths of between about 0.25 microns and about 20 microns.
20. A embolic coil formed of a platinum alloy wire and having a
textured surface which, when said embolic coil is implanted in a
patient's vasculature, provides improved platelet adhesion compared
to a non-textured surface, to promote clotting.
Description
FIELD OF THE INVENTION
[0001] The present invention concerns a novel method for occluding
the vasculature of a patient and, more particularly, a method of
treatment in which embolic coils are placed within the patient's
vasculature.
BACKGROUND OF THE INVENTION
[0002] A known technique for treating a brain aneurysm of a patient
includes the placement of embolic coils within the aneurysm. To
this end, a catheter is introduced into the vessel leading to the
aneurysm, and embolic coils are delivered to pack and fill the
aneurysm. Ordinarily, a deployment system is used to deliver the
coils, via the catheter, to the aneurysm, such as the deployment
system disclosed in Hieshima U.S. Pat. No. 6,113,622, the
disclosure of which is incorporated herein by reference.
[0003] The embolic coils act to reduce the blood flow inside of the
aneurysm. Typically the embolic coils provide a mechanical blockage
to the blood flow in the aneurysm. In this manner, the stagnation
of blood that is obtained prevents the blood flow from rupturing
the aneurysm. However, such stagnation forms a thrombus inside the
aneurysm, that eventually can get resorbed.
[0004] We have discovered a method by which the desirable
mechanical blockage of blood flow can be obtained with the addition
of platelet adhesion to the embolic coils. This allows tissue to be
able to grow, and the thrombus that forms, instead of being
resorbed, has the ability to be organized into fibrous scar tissue.
Such fibrous scar tissue achieves long term healing of the aneurysm
in contrast to the use of embolic coils that can move around with
the result that the formed thrombus may be resorbed
[0005] The method that we have discovered is useful for occluding
the vasculature of a patient. In addition to embolizing an
aneurysm, the method of the present invention may also be used for
embolizing a vessel for vessel sacrifice; for reducing or blocking
blood flow to an arterial-venous malformation or to a fistula; and
for blocking blood flow to tumors.
[0006] It is, therefore, an object of the present invention to
provide a novel method for occluding the vasculature of a patient
using implanted embolic coils in which there is improved platelet
adhesion to the coils.
[0007] A further object of the present invention to provide a novel
method for treating an aneurysm of a patient using implanted
embolic coils in which there is improved platelet adhesion to the
coils.
[0008] Another object of the present invention is to provide a
novel method for treating an aneurysm of a patient using embolic
coils and enabling tissue formation to prevent the coils from
moving around within the aneurysm.
[0009] A further object of the present invention is to provide a
novel embolic coil that is simple in construction and easy to
manufacture.
[0010] A still further object of the present invention is to
provide a novel embolic coil which provides improved platelet
adhesion.
[0011] Other objects and advantages of the present invention will
become apparent as the description proceeds.
SUMMARY OF THE INVENTION
[0012] In accordance with the present invention, a method is
provided for occluding the vasculature of a patient. The method
comprises the steps of providing a plurality of embolic coils
having a textured surface. The plurality of embolic coils having a
textured surface are introduced into the patient's vasculature. In
this manner, the textured surface provides improved platelet
adhesion compared to a non-textured surface, to promote
clotting.
[0013] In the illustrative embodiment, the surface of the embolic
coils are textured by abrasion or sandblasting. The embolic coil
comprises a platinum-tungsten alloy wire and in a specific example,
the embolic coils have a substantially uniform roughness comprising
pockets having diameters of between about 0.125 microns and about
50 microns and depths between about 0.25 microns to 20 microns.
[0014] A more detailed explanation of the invention is provided in
the following description and claims, and is illustrated in the
accompanying drawings.
BRIEF DESCRIPTION OF THE DRAWINGS
[0015] FIG. 1 is a view of an embolic coil constructed in
accordance with the principles of the present invention.
[0016] FIG. 2 is a diagram of a patient's brain aneurysm having the
coils of the present invention implanted therein.
[0017] FIG. 3 is a photomicrograph, enlarged 233.times., showing a
portion of an embolic coil with a smooth surface, prior to
texturing.
[0018] FIG. 4 is a photomicrograph, enlarged 233.times., showing a
similar portion of an embolic coil as the FIG. 3 portion, but with
texturing.
[0019] FIG. 5 is a photomicrograph, enlarged 3880.times., showing a
portion of an embolic coil with a smooth surface, prior to
texturing.
[0020] FIG. 6 is a photomicrograph, enlarged 3880.times., showing a
similar portion of an embolic coil as the FIG. 5 portion, but with
texturing
DETAILED DESCRIPTION OF THE ILLUSTRATIVE EMBODIMENT
[0021] Referring to the drawings, in FIG. 1 there is shown an
embolic coil constructed in accordance with the principles of the
present invention. Embolic coil 10 is formed by winding a
platinum-tungsten alloy wire into a helical configuration. In the
illustrative embodiment, the diameter of the wire is generally in
the range of about 0.0015 to 0.008 inches. The outside diameter of
the coil 10 is preferably in the range of about 0.006 to 0.055
inches. The embolic coil 10 shown in FIG. 1 may be straight or may
take the form of various configurations, including the forms of a
helix, a random shape configuration, or a coil within a coil
configuration.
[0022] The details of construction of an example embolic coil,
although no limitation is intended, is disclosed in Diaz et al.
U.S. Pat. No. 6,063,100, issued May 16, 2000, the disclosure of
which is incorporated herein by reference.
[0023] With the helical wound coil as illustrated in FIG, 1 the
coil is provided with a seal plug 12 at its distal end and another
seal plug 14 at its proximal end. Seal plugs 12 and 14 serve to
prevent the flow of fluid through the lumen of the coil 10.
[0024] Although no limitation is intended, as a specific example
coil 10 is formed of a platinum-tungsten alloy comprising 92%
platinum and 8% tungsten. In accordance with the present invention,
the outer surface of the coil is textured by abrasion or
sandblasting. To this end, fifty-micron diameter alumina particles
are used to texture the surface of the wire that is used to form
the coils, prior to the formation of the helical coils. It has been
found that the textured surface provides improved platelet adhesion
thus promoting clotting and subsequent endothelialization.
[0025] Although no limitation is intended, as a specific example
the texturization provides a uniform roughness comprising pockets
having diameters of between about 0.125 microns and about 50
microns and depths of between about 0.25 microns and about 20
microns. The roughness is uniform throughout the coil except if the
coil is used with a detachment system such as disclosed in Hieshima
U.S. Pat. No. 6,113,622 or Diaz et al. U.S. Pat. No. 6,063,100, a
proximal portion of the coil is not textured in order for it to
have a proper seal with a gripper so that it can released
easily.
[0026] FIG. 2 is a diagrammatic view of a patient's vessel 16
leading to an aneurysm 18 into which a number of embolic coils 10
have been introduced. The coils are introduced in a manner known in
the art, by introducing a catheter into the vessel 16, then
introducing a deployment device via the catheter to deliver the
embolic coils, one by one, to the aneurysm 18.
[0027] SEM micrographs of the non-textured vs. textured coils are
provided in FIGS. 3-6. Referring to FIG. 3, a portion of a
non-textured coil is shown in a micrograph having an enlargement of
233.times.. FIG. 4 shows a similar coil with a 233.times.
enlargement, but with texture that has been provided by
sandblasting as disclosed above. FIG. 5 is a greatly enlarged
micrograph, having an enlargement of 3380.times., of the coil
sample of FIG. 3 and FIG. 6 is a greatly enlarged micrograph having
an enlargement of 3880.times., of the coil sample of FIG. 5.
[0028] Testing was conducted using radiolabeled platelets to
evaluate an ex vivo aneurysm model. In the model, aneurysms treated
with textured coils were compared to aneurysms treated with
non-textured coils. The textured coils showed an increased in the
platelet deposition of about fifty percent over the non-texture
coils.
[0029] It can be seen that by using embolic coils that have been
textured, there is superior platelet adhesion which promotes
clotting and subsequent endothelialization. A texturing technique
has been disclosed that is simple and does not require expensive or
elaborate equipment to modify the coils. In the illustrative
embodiment the texturing technique does not require coating or ion
implantation, thereby avoiding the importation of any new materials
to the coil that would require new biocompatability testing.
[0030] Although an illustrative embodiment of the invention has
been shown and described, it is to be understood that various
modifications and substitutions may be made by those skilled in the
art without departing from the novel spirit and scope of the
present invention.
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