U.S. patent application number 10/723955 was filed with the patent office on 2005-10-13 for constitutively activated human g protein coupled receptors. Invention is credited to Behan, Dominic P., Chalmers, Derek T., Chen, Ruoping, Liaw, Chen W., Lowitz, Kevin.
Application Number | 20050227295 10/723955 |
Document ID | / |
Family ID | 29716465 |
Filed Date | 2005-10-13 |
United States Patent Application | 20050227295 |
Kind Code | A9 |
Chen, Ruoping ; et al. | October 13, 2005 |
The invention disclosed in this patent document relates to transmembrane receptors, more particularly to a human G protein-coupled receptor for which the endogenous ligand is unknown ("orphan GPCR receptors"), and most particularly to mutated (non-endogenous) versions of the human GPCRs for evidence of constitutive activity.
Inventors: | Chen, Ruoping; (San Diego, CA) ; Liaw, Chen W.; (San Diego, CA) ; Lowitz, Kevin; (Piscataway, NJ) ; Chalmers, Derek T.; (Cardiff, CA) ; Behan, Dominic P.; (San Diego, CA) | |||||||
Correspondence Address: |
COZEN O'CONNOR, P.C. 1900 MARKET STREET PHILADELPHIA PA 19103-3508 US |
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Prior Publication: |
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Family ID: | 29716465 | |||||||
Appl. No.: | 10/723955 | |||||||
Filed: | November 26, 2003 |
Application Number | Filing Date | Patent Number | ||
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10723955 | Nov 26, 2003 | |||
10417820 | Apr 16, 2003 | |||
10417820 | Apr 16, 2003 | |||
09416760 | Oct 12, 1999 | |||
09416760 | Oct 12, 1999 | |||
09170496 | Oct 13, 1998 | |||
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60110060 | Nov 27, 1998 | |||
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60121852 | Feb 26, 1999 | |||
60109213 | Nov 20, 1998 | |||
60123944 | Mar 12, 1999 | |||
60123945 | Mar 12, 1999 | |||
60123948 | Mar 12, 1999 | |||
60123951 | Mar 12, 1999 | |||
60123946 | Mar 12, 1999 | |||
60123949 | Mar 12, 1999 | |||
60152524 | Sep 3, 1999 | |||
60151114 | Aug 27, 1999 | |||
60108029 | Nov 12, 1998 | |||
60136436 | May 28, 1999 | |||
60136439 | May 28, 1999 | |||
60136567 | May 28, 1999 | |||
60137127 | May 28, 1999 | |||
60137131 | May 28, 1999 | |||
60141448 | Jun 29, 1999 | |||
60136437 | May 28, 1999 | |||
60156633 | Sep 29, 1999 | |||
60156555 | Sep 29, 1999 | |||
60156634 | Sep 29, 1999 | |||
60156653 | Sep 29, 1999 | |||
60157280 | Oct 1, 1999 | |||
60157294 | Oct 1, 1999 | |||
60157281 | Oct 1, 1999 | |||
60157293 | Oct 1, 1999 | |||
60157282 | Oct 1, 1999 | |||
Current U.S. Class: | 435/7.2 ; 435/6.14 |
Current CPC Class: | C07K 14/723 20130101; C07K 14/705 20130101; A61K 38/00 20130101; G01N 33/566 20130101 |
Class at Publication: | 435/007.2 ; 435/006 |
International Class: | C12Q 001/68; G01N 033/53; G01N 033/567 |
Sequence CWU 1
1
148 1 1260 DNA Homo sapiens 1 atggtcttct cggcagtgtt gactgcgttc
cataccggga catccaacac aacatttgtc 60 gtgtatgaaa acacctacat
gaatattaca ctccctccac cattccagca tcctgacctc 120 agtccattgc
ttagatatag ttttgaaacc atggctccca ctggtttgag ttccttgacc 180
gtgaatagta cagctgtgcc cacaacacca gcagcattta agagcctaaa cttgcctctt
240 cagatcaccc tttctgctat aatgatattc attctgtttg tgtcttttct
tgggaacttg 300 gttgtttgcc tcatggttta ccaaaaagct gccatgaggt
ctgcaattaa catcctcctt 360 gccagcctag cttttgcaga catgttgctt
gcagtgctga acatgccctt tgccctggta 420 actattctta ctacccgatg
gatttttggg aaattcttct gtagggtatc tgctatgttt 480 ttctggttat
ttgtgataga aggagtagcc atcctgctca tcattagcat agataggttc 540
cttattatag tccagaggca ggataagcta aacccatata gagctaaggt tctgattgca
600 gtttcttggg caacttcctt ttgtgtagct tttcctttag ccgtaggaaa
ccccgacctg 660 cagatacctt cccgagctcc ccagtgtgtg tttgggtaca
caaccaatcc aggctaccag 720 gcttatgtga ttttgatttc tctcatttct
ttcttcatac ccttcctggt aatactgtac 780 tcatttatgg gcatactcaa
cacccttcgg cacaatgcct tgaggatcca tagctaccct 840 gaaggtatat
gcctcagcca ggccagcaaa ctgggtctca tgagtctgca gagacctttc 900
cagatgagca ttgacatggg ctttaaaaca cgtgccttca ccactatttt gattctcttt
960 gctgtcttca ttgtctgctg ggccccattc accacttaca gccttgtggc
aacattcagt 1020 aagcactttt actatcagca caactttttt gagattagca
cctggctact gtggctctgc 1080 tacctcaagt ctgcattgaa tccgctgatc
tactactgga ggattaagaa attccatgat 1140 gcttgcctgg acatgatgcc
taagtccttc aagtttttgc cgcagctccc tggtcacaca 1200 aagcgacgga
tacgtcctag tgctgtctat gtgtgtgggg aacatcggac ggtggtgtga 1260 2 419
PRT Homo sapiens 2 Met Val Phe Ser Ala Val Leu Thr Ala Phe His Thr
Gly Thr Ser Asn 1 5 10 15 Thr Thr Phe Val Val Tyr Glu Asn Thr Tyr
Met Asn Ile Thr Leu Pro 20 25 30 Pro Pro Phe Gln His Pro Asp Leu
Ser Pro Leu Leu Arg Tyr Ser Phe 35 40 45 Glu Thr Met Ala Pro Thr
Gly Leu Ser Ser Leu Thr Val Asn Ser Thr 50 55 60 Ala Val Pro Thr
Thr Pro Ala Ala Phe Lys Ser Leu Asn Leu Pro Leu 65 70 75 80 Gln Ile
Thr Leu Ser Ala Ile Met Ile Phe Ile Leu Phe Val Ser Phe 85 90 95
Leu Gly Asn Leu Val Val Cys Leu Met Val Tyr Gln Lys Ala Ala Met 100
105 110 Arg Ser Ala Ile Asn Ile Leu Leu Ala Ser Leu Ala Phe Ala Asp
Met 115 120 125 Leu Leu Ala Val Leu Asn Met Pro Phe Ala Leu Val Thr
Ile Leu Thr 130 135 140 Thr Arg Trp Ile Phe Gly Lys Phe Phe Cys Arg
Val Ser Ala Met Phe 145 150 155 160 Phe Trp Leu Phe Val Ile Glu Gly
Val Ala Ile Leu Leu Ile Ile Ser 165 170 175 Ile Asp Arg Phe Leu Ile
Ile Val Gln Arg Gln Asp Lys Leu Asn Pro 180 185 190 Tyr Arg Ala Lys
Val Leu Ile Ala Val Ser Trp Ala Thr Ser Phe Cys 195 200 205 Val Ala
Phe Pro Leu Ala Val Gly Asn Pro Asp Leu Gln Ile Pro Ser 210 215 220
Arg Ala Pro Gln Cys Val Phe Gly Tyr Thr Thr Asn Pro Gly Tyr Gln 225
230 235 240 Ala Tyr Val Ile Leu Ile Ser Leu Ile Ser Phe Phe Ile Pro
Phe Leu 245 250 255 Val Ile Leu Tyr Ser Phe Met Gly Ile Leu Asn Thr
Leu Arg His Asn 260 265 270 Ala Leu Arg Ile His Ser Tyr Pro Glu Gly
Ile Cys Leu Ser Gln Ala 275 280 285 Ser Lys Leu Gly Leu Met Ser Leu
Gln Arg Pro Phe Gln Met Ser Ile 290 295 300 Asp Met Gly Phe Lys Thr
Arg Ala Phe Thr Thr Ile Leu Ile Leu Phe 305 310 315 320 Ala Val Phe
Ile Val Cys Trp Ala Pro Phe Thr Thr Tyr Ser Leu Val 325 330 335 Ala
Thr Phe Ser Lys His Phe Tyr Tyr Gln His Asn Phe Phe Glu Ile 340 345
350 Ser Thr Trp Leu Leu Trp Leu Cys Tyr Leu Lys Ser Ala Leu Asn Pro
355 360 365 Leu Ile Tyr Tyr Trp Arg Ile Lys Lys Phe His Asp Ala Cys
Leu Asp 370 375 380 Met Met Pro Lys Ser Phe Lys Phe Leu Pro Gln Leu
Pro Gly His Thr 385 390 395 400 Lys Arg Arg Ile Arg Pro Ser Ala Val
Tyr Val Cys Gly Glu His Arg 405 410 415 Thr Val Val 3 1119 DNA Homo
sapiens 3 atgttagcca acagctcctc aaccaacagt tctgttctcc cgtgtcctga
ctaccgacct 60 acccaccgcc tgcacttggt ggtctacagc ttggtgctgg
ctgccgggct ccccctcaac 120 gcgctagccc tctgggtctt cctgcgcgcg
ctgcgcgtgc actcggtggt gagcgtgtac 180 atgtgtaacc tggcggccag
cgacctgctc ttcaccctct cgctgcccgt tcgtctctcc 240 tactacgcac
tgcaccactg gcccttcccc gacctcctgt gccagacgac gggcgccatc 300
ttccagatga acatgtacgg cagctgcatc ttcctgatgc tcatcaacgt ggaccgctac
360 gccgccatcg tgcacccgct gcgactgcgc cacctgcggc ggccccgcgt
ggcgcggctg 420 ctctgcctgg gcgtgtgggc gctcatcctg gtgtttgccg
tgcccgccgc ccgcgtgcac 480 aggccctcgc gttgccgcta ccgggacctc
gaggtgcgcc tatgcttcga gagcttcagc 540 gacgagctgt ggaaaggcag
gctgctgccc ctcgtgctgc tggccgaggc gctgggcttc 600 ctgctgcccc
tggcggcggt ggtctactcg tcgggccgag tcttctggac gctggcgcgc 660
cccgacgcca cgcagagcca gcggcggcgg aagaccgtgc gcctcctgct ggctaacctc
720 gtcatcttcc tgctgtgctt cgtgccctac aacagcacgc tggcggtcta
cgggctgctg 780 cggagcaagc tggtggcggc cagcgtgcct gcccgcgatc
gcgtgcgcgg ggtgctgatg 840 gtgatggtgc tgctggccgg cgccaactgc
gtgctggacc cgctggtgta ctactttagc 900 gccgagggct tccgcaacac
cctgcgcggc ctgggcactc cgcaccgggc caggacctcg 960 gccaccaacg
ggacgcgggc ggcgctcgcg caatccgaaa ggtccgccgt caccaccgac 1020
gccaccaggc cggatgccgc cagtcagggg ctgctccgac cctccgactc ccactctctg
1080 tcttccttca cacagtgtcc ccaggattcc gccctctga 1119 4 372 PRT Homo
sapiens 4 Met Leu Ala Asn Ser Ser Ser Thr Asn Ser Ser Val Leu Pro
Cys Pro 1 5 10 15 Asp Tyr Arg Pro Thr His Arg Leu His Leu Val Val
Tyr Ser Leu Val 20 25 30 Leu Ala Ala Gly Leu Pro Leu Asn Ala Leu
Ala Leu Trp Val Phe Leu 35 40 45 Arg Ala Leu Arg Val His Ser Val
Val Ser Val Tyr Met Cys Asn Leu 50 55 60 Ala Ala Ser Asp Leu Leu
Phe Thr Leu Ser Leu Pro Val Arg Leu Ser 65 70 75 80 Tyr Tyr Ala Leu
His His Trp Pro Phe Pro Asp Leu Leu Cys Gln Thr 85 90 95 Thr Gly
Ala Ile Phe Gln Met Asn Met Tyr Gly Ser Cys Ile Phe Leu 100 105 110
Met Leu Ile Asn Val Asp Arg Tyr Ala Ala Ile Val His Pro Leu Arg 115
120 125 Leu Arg His Leu Arg Arg Pro Arg Val Ala Arg Leu Leu Cys Leu
Gly 130 135 140 Val Trp Ala Leu Ile Leu Val Phe Ala Val Pro Ala Ala
Arg Val His 145 150 155 160 Arg Pro Ser Arg Cys Arg Tyr Arg Asp Leu
Glu Val Arg Leu Cys Phe 165 170 175 Glu Ser Phe Ser Asp Glu Leu Trp
Lys Gly Arg Leu Leu Pro Leu Val 180 185 190 Leu Leu Ala Glu Ala Leu
Gly Phe Leu Leu Pro Leu Ala Ala Val Val 195 200 205 Tyr Ser Ser Gly
Arg Val Phe Trp Thr Leu Ala Arg Pro Asp Ala Thr 210 215 220 Gln Ser
Gln Arg Arg Arg Lys Thr Val Arg Leu Leu Leu Ala Asn Leu 225 230 235
240 Val Ile Phe Leu Leu Cys Phe Val Pro Tyr Asn Ser Thr Leu Ala Val
245 250 255 Tyr Gly Leu Leu Arg Ser Lys Leu Val Ala Ala Ser Val Pro
Ala Arg 260 265 270 Asp Arg Val Arg Gly Val Leu Met Val Met Val Leu
Leu Ala Gly Ala 275 280 285 Asn Cys Val Leu Asp Pro Leu Val Tyr Tyr
Phe Ser Ala Glu Gly Phe 290 295 300 Arg Asn Thr Leu Arg Gly Leu Gly
Thr Pro His Arg Ala Arg Thr Ser 305 310 315 320 Ala Thr Asn Gly Thr
Arg Ala Ala Leu Ala Gln Ser Glu Arg Ser Ala 325 330 335 Val Thr Thr
Asp Ala Thr Arg Pro Asp Ala Ala Ser Gln Gly Leu Leu 340 345 350 Arg
Pro Ser Asp Ser His Ser Leu Ser Ser Phe Thr Gln Cys Pro Gln 355 360
365 Asp Ser Ala Leu 370 5 1107 DNA Homo sapiens 5 atggccaact
ccacagggct gaacgcctca gaagtcgcag gctcgttggg gttgatcctg 60
gcagctgtcg tggaggtggg ggcactgctg ggcaacggcg cgctgctggt cgtggtgctg
120 cgcacgccgg gactgcgcga cgcgctctac ctggcgcacc tgtgcgtcgt
ggacctgctg 180 gcggccgcct ccatcatgcc gctgggcctg ctggccgcac
cgccgcccgg gctgggccgc 240 gtgcgcctgg gccccgcgcc atgccgcgcc
gctcgcttcc tctccgccgc tctgctgccg 300 gcctgcacgc tcggggtggc
cgcacttggc ctggcacgct accgcctcat cgtgcacccg 360 ctgcggccag
gctcgcggcc gccgcctgtg ctcgtgctca ccgccgtgtg ggccgcggcg 420
ggactgctgg gcgcgctctc cctgctcggc ccgccgcccg caccgccccc tgctcctgct
480 cgctgctcgg tcctggctgg gggcctcggg cccttccggc cgctctgggc
cctgctggcc 540 ttcgcgctgc ccgccctcct gctgctcggc gcctacggcg
gcatcttcgt ggtggcgcgt 600 cgcgctgccc tgaggccccc acggccggcg
cgcgggtccc gactccgctc ggactctctg 660 gatagccgcc tttccatctt
gccgccgctc cggcctcgcc tgcccggggg caaggcggcc 720 ctggccccag
cgctggccgt gggccaattt gcagcctgct ggctgcctta tggctgcgcg 780
tgcctggcgc ccgcagcgcg ggccgcggaa gccgaagcgg ctgtcacctg ggtcgcctac
840 tcggccttcg cggctcaccc cttcctgtac gggctgctgc agcgccccgt
gcgcttggca 900 ctgggccgcc tctctcgccg tgcactgcct ggacctgtgc
gggcctgcac tccgcaagcc 960 tggcacccgc gggcactctt gcaatgcctc
cagagacccc cagagggccc tgccgtaggc 1020 ccttctgagg ctccagaaca
gacccccgag ttggcaggag ggcggagccc cgcataccag 1080 gggccacctg
agagttctct ctcctga 1107 6 368 PRT Homo sapiens 6 Met Ala Asn Ser
Thr Gly Leu Asn Ala Ser Glu Val Ala Gly Ser Leu 1 5 10 15 Gly Leu
Ile Leu Ala Ala Val Val Glu Val Gly Ala Leu Leu Gly Asn 20 25 30
Gly Ala Leu Leu Val Val Val Leu Arg Thr Pro Gly Leu Arg Asp Ala 35
40 45 Leu Tyr Leu Ala His Leu Cys Val Val Asp Leu Leu Ala Ala Ala
Ser 50 55 60 Ile Met Pro Leu Gly Leu Leu Ala Ala Pro Pro Pro Gly
Leu Gly Arg 65 70 75 80 Val Arg Leu Gly Pro Ala Pro Cys Arg Ala Ala
Arg Phe Leu Ser Ala 85 90 95 Ala Leu Leu Pro Ala Cys Thr Leu Gly
Val Ala Ala Leu Gly Leu Ala 100 105 110 Arg Tyr Arg Leu Ile Val His
Pro Leu Arg Pro Gly Ser Arg Pro Pro 115 120 125 Pro Val Leu Val Leu
Thr Ala Val Trp Ala Ala Ala Gly Leu Leu Gly 130 135 140 Ala Leu Ser
Leu Leu Gly Pro Pro Pro Ala Pro Pro Pro Ala Pro Ala 145 150 155 160
Arg Cys Ser Val Leu Ala Gly Gly Leu Gly Pro Phe Arg Pro Leu Trp 165
170 175 Ala Leu Leu Ala Phe Ala Leu Pro Ala Leu Leu Leu Leu Gly Ala
Tyr 180 185 190 Gly Gly Ile Phe Val Val Ala Arg Arg Ala Ala Leu Arg
Pro Pro Arg 195 200 205 Pro Ala Arg Gly Ser Arg Leu Arg Ser Asp Ser
Leu Asp Ser Arg Leu 210 215 220 Ser Ile Leu Pro Pro Leu Arg Pro Arg
Leu Pro Gly Gly Lys Ala Ala 225 230 235 240 Leu Ala Pro Ala Leu Ala
Val Gly Gln Phe Ala Ala Cys Trp Leu Pro 245 250 255 Tyr Gly Cys Ala
Cys Leu Ala Pro Ala Ala Arg Ala Ala Glu Ala Glu 260 265 270 Ala Ala
Val Thr Trp Val Ala Tyr Ser Ala Phe Ala Ala His Pro Phe 275 280 285
Leu Tyr Gly Leu Leu Gln Arg Pro Val Arg Leu Ala Leu Gly Arg Leu 290
295 300 Ser Arg Arg Ala Leu Pro Gly Pro Val Arg Ala Cys Thr Pro Gln
Ala 305 310 315 320 Trp His Pro Arg Ala Leu Leu Gln Cys Leu Gln Arg
Pro Pro Glu Gly 325 330 335 Pro Ala Val Gly Pro Ser Glu Ala Pro Glu
Gln Thr Pro Glu Leu Ala 340 345 350 Gly Gly Arg Ser Pro Ala Tyr Gln
Gly Pro Pro Glu Ser Ser Leu Ser 355 360 365 7 1008 DNA Homo sapiens
7 atggaatcat ctttctcatt tggagtgatc cttgctgtcc tggcctccct catcattgct
60 actaacacac tagtggctgt ggctgtgctg ctgttgatcc acaagaatga
tggtgtcagt 120 ctctgcttca ccttgaatct ggctgtggct gacaccttga
ttggtgtggc catctctggc 180 ctactcacag accagctctc cagcccttct
cggcccacac agaagaccct gtgcagcctg 240 cggatggcat ttgtcacttc
ctccgcagct gcctctgtcc tcacggtcat gctgatcacc 300 tttgacaggt
accttgccat caagcagccc ttccgctact tgaagatcat gagtgggttc 360
gtggccgggg cctgcattgc cgggctgtgg ttagtgtctt acctcattgg cttcctccca
420 ctcggaatcc ccatgttcca gcagactgcc tacaaagggc agtgcagctt
ctttgctgta 480 tttcaccctc acttcgtgct gaccctctcc tgcgttggct
tcttcccagc catgctcctc 540 tttgtcttct tctactgcga catgctcaag
attgcctcca tgcacagcca gcagattcga 600 aagatggaac atgcaggagc
catggctgga ggttatcgat ccccacggac tcccagcgac 660 ttcaaagctc
tccgtactgt gtctgttctc attgggagct ttgctctatc ctggaccccc 720
ttccttatca ctggcattgt gcaggtggcc tgccaggagt gtcacctcta cctagtgctg
780 gaacggtacc tgtggctgct cggcgtgggc aactccctgc tcaacccact
catctatgcc 840 tattggcaga aggaggtgcg actgcagctc taccacatgg
ccctaggagt gaagaaggtg 900 ctcacctcat tcctcctctt tctctcggcc
aggaattgtg gcccagagag gcccagggaa 960 agttcctgtc acatcgtcac
tatctccagc tcagagtttg atggctaa 1008 8 335 PRT Homo sapiens 8 Met
Glu Ser Ser Phe Ser Phe Gly Val Ile Leu Ala Val Leu Ala Ser 1 5 10
15 Leu Ile Ile Ala Thr Asn Thr Leu Val Ala Val Ala Val Leu Leu Leu
20 25 30 Ile His Lys Asn Asp Gly Val Ser Leu Cys Phe Thr Leu Asn
Leu Ala 35 40 45 Val Ala Asp Thr Leu Ile Gly Val Ala Ile Ser Gly
Leu Leu Thr Asp 50 55 60 Gln Leu Ser Ser Pro Ser Arg Pro Thr Gln
Lys Thr Leu Cys Ser Leu 65 70 75 80 Arg Met Ala Phe Val Thr Ser Ser
Ala Ala Ala Ser Val Leu Thr Val 85 90 95 Met Leu Ile Thr Phe Asp
Arg Tyr Leu Ala Ile Lys Gln Pro Phe Arg 100 105 110 Tyr Leu Lys Ile
Met Ser Gly Phe Val Ala Gly Ala Cys Ile Ala Gly 115 120 125 Leu Trp
Leu Val Ser Tyr Leu Ile Gly Phe Leu Pro Leu Gly Ile Pro 130 135 140
Met Phe Gln Gln Thr Ala Tyr Lys Gly Gln Cys Ser Phe Phe Ala Val 145
150 155 160 Phe His Pro His Phe Val Leu Thr Leu Ser Cys Val Gly Phe
Phe Pro 165 170 175 Ala Met Leu Leu Phe Val Phe Phe Tyr Cys Asp Met
Leu Lys Ile Ala 180 185 190 Ser Met His Ser Gln Gln Ile Arg Lys Met
Glu His Ala Gly Ala Met 195 200 205 Ala Gly Gly Tyr Arg Ser Pro Arg
Thr Pro Ser Asp Phe Lys Ala Leu 210 215 220 Arg Thr Val Ser Val Leu
Ile Gly Ser Phe Ala Leu Ser Trp Thr Pro 225 230 235 240 Phe Leu Ile
Thr Gly Ile Val Gln Val Ala Cys Gln Glu Cys His Leu 245 250 255 Tyr
Leu Val Leu Glu Arg Tyr Leu Trp Leu Leu Gly Val Gly Asn Ser 260 265
270 Leu Leu Asn Pro Leu Ile Tyr Ala Tyr Trp Gln Lys Glu Val Arg Leu
275 280 285 Gln Leu Tyr His Met Ala Leu Gly Val Lys Lys Val Leu Thr
Ser Phe 290 295 300 Leu Leu Phe Leu Ser Ala Arg Asn Cys Gly Pro Glu
Arg Pro Arg Glu 305 310 315 320 Ser Ser Cys His Ile Val Thr Ile Ser
Ser Ser Glu Phe Asp Gly 325 330 335 9 1413 DNA Homo sapiens 9
atggacacta ccatggaagc tgacctgggt gccactggcc acaggccccg cacagagctt
60 gatgatgagg actcctaccc ccaaggtggc tgggacacgg tcttcctggt
ggccctgctg 120 ctccttgggc tgccagccaa tgggttgatg gcgtggctgg
ccggctccca ggcccggcat 180 ggagctggca cgcgtctggc gctgctcctg
ctcagcctgg ccctctctga cttcttgttc 240 ctggcagcag cggccttcca
gatcctagag atccggcatg ggggacactg gccgctgggg 300 acagctgcct
gccgcttcta ctacttccta tggggcgtgt cctactcctc cggcctcttc 360
ctgctggccg ccctcagcct cgaccgctgc ctgctggcgc tgtgcccaca ctggtaccct
420 gggcaccgcc cagtccgcct gcccctctgg gtctgcgccg gtgtctgggt
gctggccaca 480 ctcttcagcg tgccctggct ggtcttcccc gaggctgccg
tctggtggta cgacctggtc 540 atctgcctgg acttctggga cagcgaggag
ctgtcgctga ggatgctgga ggtcctgggg 600 ggcttcctgc ctttcctcct
gctgctcgtc tgccacgtgc tcacccaggc cacagcctgt 660 cgcacctgcc
accgccaaca gcagcccgca gcctgccggg gcttcgcccg tgtggccagg 720
accattctgt cagcctatgt ggtcctgagg ctgccctacc agctggccca gctgctctac
780 ctggccttcc tgtgggacgt ctactctggc tacctgctct gggaggccct
ggtctactcc 840 gactacctga tcctactcaa cagctgcctc agccccttcc
tctgcctcat ggccagtgcc 900 gacctccgga ccctgctgcg ctccgtgctc
tcgtccttcg cggcagctct ctgcgaggag 960 cggccgggca gcttcacgcc
cactgagcca cagacccagc tagattctga gggtccaact 1020 ctgccagagc
cgatggcaga ggcccagtca cagatggatc ctgtggccca gcctcaggtg 1080
aaccccacac tccagccacg atcggatccc acagctcagc cacagctgaa
ccctacggcc 1140 cagccacagt cggatcccac agcccagcca cagctgaacc
tcatggccca gccacagtca 1200 gattctgtgg cccagccaca ggcagacact
aacgtccaga cccctgcacc tgctgccagt 1260 tctgtgccca gtccctgtga
tgaagcttcc ccaaccccat cctcgcatcc taccccaggg 1320 gcccttgagg
acccagccac acctcctgcc tctgaaggag aaagccccag cagcaccccg 1380
ccagaggcgg ccccgggcgc aggccccacg tga 1413 10 468 PRT Homo sapiens
10 Met Asp Thr Thr Met Glu Ala Asp Leu Gly Ala Thr Gly His Arg Pro
1 5 10 15 Arg Thr Glu Leu Asp Asp Glu Asp Ser Tyr Pro Gln Gly Gly
Trp Asp 20 25 30 Thr Val Phe Leu Val Ala Leu Leu Leu Leu Gly Leu
Pro Ala Asn Gly 35 40 45 Leu Met Ala Trp Leu Ala Gly Ser Gln Ala
Arg His Gly Ala Gly Thr 50 55 60 Arg Leu Ala Leu Leu Leu Leu Ser
Leu Ala Leu Ser Asp Phe Leu Phe 65 70 75 80 Leu Ala Ala Ala Ala Phe
Gln Ile Leu Glu Ile Arg His Gly Gly His 85 90 95 Trp Pro Leu Gly
Thr Ala Ala Cys Arg Phe Tyr Tyr Phe Leu Trp Gly 100 105 110 Val Ser
Tyr Ser Ser Gly Leu Phe Leu Leu Ala Ala Leu Ser Leu Asp 115 120 125
Arg Cys Leu Leu Ala Leu Cys Pro His Trp Tyr Pro Gly His Arg Pro 130
135 140 Val Arg Leu Pro Leu Trp Val Cys Ala Gly Val Trp Val Leu Ala
Thr 145 150 155 160 Leu Phe Ser Val Pro Trp Leu Val Phe Pro Glu Ala
Ala Val Trp Trp 165 170 175 Tyr Asp Leu Val Ile Cys Leu Asp Phe Trp
Asp Ser Glu Glu Leu Ser 180 185 190 Leu Arg Met Leu Glu Val Leu Gly
Gly Phe Leu Pro Phe Leu Leu Leu 195 200 205 Leu Val Cys His Val Leu
Thr Gln Ala Thr Arg Thr Cys His Arg Gln 210 215 220 Gln Gln Pro Ala
Ala Cys Arg Gly Phe Ala Arg Val Ala Arg Thr Ile 225 230 235 240 Leu
Ser Ala Tyr Val Val Leu Arg Leu Pro Tyr Gln Leu Ala Gln Leu 245 250
255 Leu Tyr Leu Ala Phe Leu Trp Asp Val Tyr Ser Gly Tyr Leu Leu Trp
260 265 270 Glu Ala Leu Val Tyr Ser Asp Tyr Leu Ile Leu Leu Asn Ser
Cys Leu 275 280 285 Ser Pro Phe Leu Cys Leu Met Ala Ser Ala Asp Leu
Arg Thr Leu Leu 290 295 300 Arg Ser Val Leu Ser Ser Phe Ala Ala Ala
Leu Cys Glu Glu Arg Pro 305 310 315 320 Gly Ser Phe Thr Pro Thr Glu
Pro Gln Thr Gln Leu Asp Ser Glu Gly 325 330 335 Pro Thr Leu Pro Glu
Pro Met Ala Glu Ala Gln Ser Gln Met Asp Pro 340 345 350 Val Ala Gln
Pro Gln Val Asn Pro Thr Leu Gln Pro Arg Ser Asp Pro 355 360 365 Thr
Ala Gln Pro Gln Leu Asn Pro Thr Ala Gln Pro Gln Ser Asp Pro 370 375
380 Thr Ala Gln Pro Gln Leu Asn Leu Met Ala Gln Pro Gln Ser Asp Ser
385 390 395 400 Val Ala Gln Pro Gln Ala Asp Thr Asn Val Gln Thr Pro
Ala Pro Ala 405 410 415 Ala Ser Ser Val Pro Ser Pro Cys Asp Glu Ala
Ser Pro Thr Pro Ser 420 425 430 Ser His Pro Thr Pro Gly Ala Leu Glu
Asp Pro Ala Thr Pro Pro Ala 435 440 445 Ser Glu Gly Glu Ser Pro Ser
Ser Thr Pro Pro Glu Ala Ala Pro Gly 450 455 460 Ala Gly Pro Thr 465
11 1248 DNA Homo sapiens 11 atgtcaggga tggaaaaact tcagaatgct
tcctggatct accagcagaa actagaagat 60 ccattccaga aacacctgaa
cagcaccgag gagtatctgg ccttcctctg cggacctcgg 120 cgcagccact
tcttcctccc cgtgtctgtg gtgtatgtgc caatttttgt ggtgggggtc 180
attggcaatg tcctggtgtg cctggtgatt ctgcagcacc aggctatgaa gacgcccacc
240 aactactacc tcttcagcct ggcggtctct gacctcctgg tcctgctcct
tggaatgccc 300 ctggaggtct atgagatgtg gcgcaactac cctttcttgt
tcgggcccgt gggctgctac 360 ttcaagacgg ccctctttga gaccgtgtgc
ttcgcctcca tcctcagcat caccaccgtc 420 agcgtggagc gctacgtggc
catcctacac ccgttccgcg ccaaactgca gagcacccgg 480 cgccgggccc
tcaggatcct cggcatcgtc tggggcttct ccgtgctctt ctccctgccc 540
aacaccagca tccatggcat caagttccac tacttcccca atgggtccct ggtcccaggt
600 tcggccacct gtacggtcat caagcccatg tggatctaca atttcatcat
ccaggtcacc 660 tccttcctat tctacctcct ccccatgact gtcatcagtg
tcctctacta cctcatggca 720 ctcagactaa agaaagacaa atctcttgag
gcagatgaag ggaatgcaaa tattcaaaga 780 ccctgcagaa aatcagtcaa
caagatgctg tttgtcttgg tcttagtgtt tgctatctgt 840 tgggccccgt
tccacattga ccgactcttc ttcagctttg tggaggagtg gagtgaatcc 900
ctggctgctg tgttcaacct cgtccatgtg gtgtcaggtg tcttcttcta cctgagctca
960 gctgtcaacc ccattatcta taacctactg tctcgccgct tccaggcagc
attccagaat 1020 gtgatctctt ctttccacaa acagtggcac tcccagcatg
acccacagtt gccacctgcc 1080 cagcggaaca tcttcctgac agaatgccac
tttgtggagc tgaccgaaga tataggtccc 1140 caattcccat gtcagtcatc
catgcacaac tctcacctcc caacagccct ctctagtgaa 1200 cagatgtcaa
gaacaaacta tcaaagcttc cactttaaca aaacctga 1248 12 415 PRT Homo
sapiens 12 Met Ser Gly Met Glu Lys Leu Gln Asn Ala Ser Trp Ile Tyr
Gln Gln 1 5 10 15 Lys Leu Glu Asp Pro Phe Gln Lys His Leu Asn Ser
Thr Glu Glu Tyr 20 25 30 Leu Ala Phe Leu Cys Gly Pro Arg Arg Ser
His Phe Phe Leu Pro Val 35 40 45 Ser Val Val Tyr Val Pro Ile Phe
Val Val Gly Val Ile Gly Asn Val 50 55 60 Leu Val Cys Leu Val Ile
Leu Gln His Gln Ala Met Lys Thr Pro Thr 65 70 75 80 Asn Tyr Tyr Leu
Phe Ser Leu Ala Val Ser Asp Leu Leu Val Leu Leu 85 90 95 Leu Gly
Met Pro Leu Glu Val Tyr Glu Met Trp Arg Asn Tyr Pro Phe 100 105 110
Leu Phe Gly Pro Val Gly Cys Tyr Phe Lys Thr Ala Leu Phe Glu Thr 115
120 125 Val Cys Phe Ala Ser Ile Leu Ser Ile Thr Thr Val Ser Val Glu
Arg 130 135 140 Tyr Val Ala Ile Leu His Pro Phe Arg Ala Lys Leu Gln
Ser Thr Arg 145 150 155 160 Arg Arg Ala Leu Arg Ile Leu Gly Ile Val
Trp Gly Phe Ser Val Leu 165 170 175 Phe Ser Leu Pro Asn Thr Ser Ile
His Gly Ile Lys Phe His Tyr Phe 180 185 190 Pro Asn Gly Ser Leu Val
Pro Gly Ser Ala Thr Cys Thr Val Ile Lys 195 200 205 Pro Met Trp Ile
Tyr Asn Phe Ile Ile Gln Val Thr Ser Phe Leu Phe 210 215 220 Tyr Leu
Leu Pro Met Thr Val Ile Ser Val Leu Tyr Tyr Leu Met Ala 225 230 235
240 Leu Arg Leu Lys Lys Asp Lys Ser Leu Glu Ala Asp Glu Gly Asn Ala
245 250 255 Asn Ile Gln Arg Pro Cys Arg Lys Ser Val Asn Lys Met Leu
Phe Val 260 265 270 Leu Val Leu Val Phe Ala Ile Cys Trp Ala Pro Phe
His Ile Asp Arg 275 280 285 Leu Phe Phe Ser Phe Val Glu Glu Trp Ser
Glu Ser Leu Ala Ala Val 290 295 300 Phe Asn Leu Val His Val Val Ser
Gly Val Phe Phe Tyr Leu Ser Ser 305 310 315 320 Ala Val Asn Pro Ile
Ile Tyr Asn Leu Leu Ser Arg Arg Phe Gln Ala 325 330 335 Ala Phe Gln
Asn Val Ile Ser Ser Phe His Lys Gln Trp His Ser Gln 340 345 350 His
Asp Pro Gln Leu Pro Pro Ala Gln Arg Asn Ile Phe Leu Thr Glu 355 360
365 Cys His Phe Val Glu Leu Thr Glu Asp Ile Gly Pro Gln Phe Pro Cys
370 375 380 Gln Ser Ser Met His Asn Ser His Leu Pro Thr Ala Leu Ser
Ser Glu 385 390 395 400 Gln Met Ser Arg Thr Asn Tyr Gln Ser Phe His
Phe Asn Lys Thr 405 410 415 13 1173 DNA Homo sapiens 13 atgccagata
ctaatagcac aatcaattta tcactaagca ctcgtgttac tttagcattt 60
tttatgtcct tagtagcttt tgctataatg ctaggaaatg ctttggtcat tttagctttt
120 gtggtggaca aaaaccttag acatcgaagt agttattttt ttcttaactt
ggccatctct 180 gacttctttg tgggtgtgat ctccattcct ttgtacatcc
ctcacacgct gttcgaatgg 240 gattttggaa aggaaatctg tgtattttgg
ctcactactg actatctgtt atgtacagca 300 tctgtatata acattgtcct
catcagctat gatcgatacc tgtcagtctc aaatgctgtg 360 tcttatagaa
ctcaacatac tggggtcttg aagattgtta ctctgatggt ggccgtttgg 420
gtgctggcct tcttagtgaa tgggccaatg attctagttt cagagtcttg gaaggatgaa
480 ggtagtgaat gtgaacctgg atttttttcg gaatggtaca tccttgccat
cacatcattc 540 ttggaattcg tgatcccagt catcttagtc gcttatttca
acatgaatat ttattggagc 600 ctgtggaagc gtgatcatct cagtaggtgc
caaagccatc ctggactgac tgctgtctct 660 tccaacatct gtggacactc
attcagaggt agactatctt caaggagatc tctttctgca 720 tcgacagaag
ttcctgcatc ctttcattca gagagacaga ggagaaagag tagtctcatg 780
ttttcctcaa gaaccaagat gaatagcaat acaattgctt ccaaaatggg ttccttctcc
840 caatcagatt ctgtagctct tcaccaaagg gaacatgttg aactgcttag
agccaggaga 900 ttagccaagt cactggccat tctcttaggg gtttttgctg
tttgctgggc tccatattct 960 ctgttcacaa ttgtcctttc attttattcc
tcagcaacag gtcctaaatc agtttggtat 1020 agaattgcat tttggcttca
gtggttcaat tcctttgtca atcctctttt gtatccattg 1080 tgtcacaagc
gctttcaaaa ggctttcttg aaaatatttt gtataaaaaa gcaacctcta 1140
ccatcacaac acagtcggtc agtatcttct taa 1173 14 390 PRT Homo sapiens
14 Met Pro Asp Thr Asn Ser Thr Ile Asn Leu Ser Leu Ser Thr Arg Val
1 5 10 15 Thr Leu Ala Phe Phe Met Ser Leu Val Ala Phe Ala Ile Met
Leu Gly 20 25 30 Asn Ala Leu Val Ile Leu Ala Phe Val Val Asp Lys
Asn Leu Arg His 35 40 45 Arg Ser Ser Tyr Phe Phe Leu Asn Leu Ala
Ile Ser Asp Phe Phe Val 50 55 60 Gly Val Ile Ser Ile Pro Leu Tyr
Ile Pro His Thr Leu Phe Glu Trp 65 70 75 80 Asp Phe Gly Lys Glu Ile
Cys Val Phe Trp Leu Thr Thr Asp Tyr Leu 85 90 95 Leu Cys Thr Ala
Ser Val Tyr Asn Ile Val Leu Ile Ser Tyr Asp Arg 100 105 110 Tyr Leu
Ser Val Ser Asn Ala Val Ser Tyr Arg Thr Gln His Thr Gly 115 120 125
Val Leu Lys Ile Val Thr Leu Met Val Ala Val Trp Val Leu Ala Phe 130
135 140 Leu Val Asn Gly Pro Met Ile Leu Val Ser Glu Ser Trp Lys Asp
Glu 145 150 155 160 Gly Ser Glu Cys Glu Pro Gly Phe Phe Ser Glu Trp
Tyr Ile Leu Ala 165 170 175 Ile Thr Ser Phe Leu Glu Phe Val Ile Pro
Val Ile Leu Val Ala Tyr 180 185 190 Phe Asn Met Asn Ile Tyr Trp Ser
Leu Trp Lys Arg Asp His Leu Ser 195 200 205 Arg Cys Gln Ser His Pro
Gly Leu Thr Ala Val Ser Ser Asn Ile Cys 210 215 220 Gly His Ser Phe
Arg Gly Arg Leu Ser Ser Arg Arg Ser Leu Ser Ala 225 230 235 240 Ser
Thr Glu Val Pro Ala Ser Phe His Ser Glu Arg Gln Arg Arg Lys 245 250
255 Ser Ser Leu Met Phe Ser Ser Arg Thr Lys Met Asn Ser Asn Thr Ile
260 265 270 Ala Ser Lys Met Gly Ser Phe Ser Gln Ser Asp Ser Val Ala
Leu His 275 280 285 Gln Arg Glu His Val Glu Leu Leu Arg Ala Arg Arg
Leu Ala Lys Ser 290 295 300 Leu Ala Ile Leu Leu Gly Val Phe Ala Val
Cys Trp Ala Pro Tyr Ser 305 310 315 320 Leu Phe Thr Ile Val Leu Ser
Phe Tyr Ser Ser Ala Thr Gly Pro Lys 325 330 335 Ser Val Trp Tyr Arg
Ile Ala Phe Trp Leu Gln Trp Phe Asn Ser Phe 340 345 350 Val Asn Pro
Leu Leu Tyr Pro Leu Cys His Lys Arg Phe Gln Lys Ala 355 360 365 Phe
Leu Lys Ile Phe Cys Ile Lys Lys Gln Pro Leu Pro Ser Gln His 370 375
380 Ser Arg Ser Val Ser Ser 385 390 15 30 DNA Artificial Sequence
Novel Sequence 15 ggaaagctta acgatcccca ggagcaacat 30 16 31 DNA
Artificial Sequence Novel Sequence 16 ctgggatcct acgagagcat
ttttcacaca g 31 17 1128 DNA Homo sapiens 17 atggcgaacg cgagcgagcc
gggtggcagc ggcggcggcg aggcggccgc cctgggcctc 60 aagctggcca
cgctcagcct gctgctgtgc gtgagcctag cgggcaacgt gctgttcgcg 120
ctgctgatcg tgcgggagcg cagcctgcac cgcgccccgt actacctgct gctcgacctg
180 tgcctggccg acgggctgcg cgcgctcgcc tgcctcccgg ccgtcatgct
ggcggcgcgg 240 cgtgcggcgg ccgcggcggg ggcgccgccg ggcgcgctgg
gctgcaagct gctcgccttc 300 ctggccgcgc tcttctgctt ccacgccgcc
ttcctgctgc tgggcgtggg cgtcacccgc 360 tacctggcca tcgcgcacca
ccgcttctat gcagagcgcc tggccggctg gccgtgcgcc 420 gccatgctgg
tgtgcgccgc ctgggcgctg gcgctggccg cggccttccc gccagtgctg 480
gacggcggtg gcgacgacga ggacgcgccg tgcgccctgg agcagcggcc cgacggcgcc
540 cccggcgcgc tgggcttcct gctgctgctg gccgtggtgg tgggcgccac
gcacctcgtc 600 tacctccgcc tgctcttctt catccacgac cgccgcaaga
tgcggcccgc gcgcctggtg 660 cccgccgtca gccacgactg gaccttccac
ggcccgggcg ccaccggcca ggcggccgcc 720 aactggacgg cgggcttcgg
ccgcgggccc acgccgcccg cgcttgtggg catccggccc 780 gcagggccgg
gccgcggcgc gcgccgcctc ctcgtgctgg aagaattcaa gacggagaag 840
aggctgtgca agatgttcta cgccgtcacg ctgctcttcc tgctcctctg ggggccctac
900 gtcgtggcca gctacctgcg ggtcctggtg cggcccggcg ccgtccccca
ggcctacctg 960 acggcctccg tgtggctgac cttcgcgcag gccggcatca
accccgtcgt gtgcttcctc 1020 ttcaacaggg agctgaggga ctgcttcagg
gcccagttcc cctgctgcca gagcccccgg 1080 accacccagg cgacccatcc
ctgcgacctg aaaggcattg gtttatga 1128 18 375 PRT Homo sapiens 18 Met
Ala Asn Ala Ser Glu Pro Gly Gly Ser Gly Gly Gly Glu Ala Ala 1 5 10
15 Ala Leu Gly Leu Lys Leu Ala Thr Leu Ser Leu Leu Leu Cys Val Ser
20 25 30 Leu Ala Gly Asn Val Leu Phe Ala Leu Leu Ile Val Arg Glu
Arg Ser 35 40 45 Leu His Arg Ala Pro Tyr Tyr Leu Leu Leu Asp Leu
Cys Leu Ala Asp 50 55 60 Gly Leu Arg Ala Leu Ala Cys Leu Pro Ala
Val Met Leu Ala Ala Arg 65 70 75 80 Arg Ala Ala Ala Ala Ala Gly Ala
Pro Pro Gly Ala Leu Gly Cys Lys 85 90 95 Leu Leu Ala Phe Leu Ala
Ala Leu Phe Cys Phe His Ala Ala Phe Leu 100 105 110 Leu Leu Gly Val
Gly Val Thr Arg Tyr Leu Ala Ile Ala His His Arg 115 120 125 Phe Tyr
Ala Glu Arg Leu Ala Gly Trp Pro Cys Ala Ala Met Leu Val 130 135 140
Cys Ala Ala Trp Ala Leu Ala Leu Ala Ala Ala Phe Pro Pro Val Leu 145
150 155 160 Asp Gly Gly Gly Asp Asp Glu Asp Ala Pro Cys Ala Leu Glu
Gln Arg 165 170 175 Pro Asp Gly Ala Pro Gly Ala Leu Gly Phe Leu Leu
Leu Leu Ala Val 180 185 190 Val Val Gly Ala Thr His Leu Val Tyr Leu
Arg Leu Leu Phe Phe Ile 195 200 205 His Asp Arg Arg Lys Met Arg Pro
Ala Arg Leu Val Pro Ala Val Ser 210 215 220 His Asp Trp Thr Phe His
Gly Pro Gly Ala Thr Gly Gln Ala Ala Ala 225 230 235 240 Asn Trp Thr
Ala Gly Phe Gly Arg Gly Pro Thr Pro Pro Ala Leu Val 245 250 255 Gly
Ile Arg Pro Ala Gly Pro Gly Arg Gly Ala Arg Arg Leu Leu Val 260 265
270 Leu Glu Glu Phe Lys Thr Glu Lys Arg Leu Cys Lys Met Phe Tyr Ala
275 280 285 Val Thr Leu Leu Phe Leu Leu Leu Trp Gly Pro Tyr Val Val
Ala Ser 290 295 300 Tyr Leu Arg Val Leu Val Arg Pro Gly Ala Val Pro
Gln Ala Tyr Leu 305 310 315 320 Thr Ala Ser Val Trp Leu Thr Phe Ala
Gln Ala Gly Ile Asn Pro Val 325 330 335 Val Cys Phe Leu Phe Asn Arg
Glu Leu Arg Asp Cys Phe Arg Ala Gln 340 345 350 Phe Pro Cys Cys Gln
Ser Pro Arg Thr Thr Gln Ala Thr His Pro Cys 355 360 365 Asp Leu Lys
Gly Ile Gly Leu 370 375 19 1002 DNA Homo sapiens 19 atgaacacca
cagtgatgca aggcttcaac agatctgagc ggtgccccag agacactcgg 60
atagtacagc tggtattccc agccctctac acagtggttt tcttgaccgg catcctgctg
120 aatactttgg ctctgtgggt gtttgttcac atccccagct cctccacctt
catcatctac 180 ctcaaaaaca ctttggtggc cgacttgata atgacactca
tgcttccttt caaaatcctc 240 tctgactcac acctggcacc ctggcagctc
agagcttttg tgtgtcgttt ttcttcggtg 300 atattttatg agaccatgta
tgtgggcatc gtgctgttag ggctcatagc ctttgacaga 360 ttcctcaaga
tcatcagacc tttgagaaat atttttctaa aaaaacctgt ttttgcaaaa 420
acggtctcaa tcttcatctg gttctttttg ttcttcatct ccctgccaaa tacgatcttg
480 agcaacaagg aagcaacacc atcgtctgtg aaaaagtgtg cttccttaaa
ggggcctctg 540 gggctgaaat ggcatcaaat ggtaaataac atatgccagt
ttattttctg gactgttttt 600 atcctaatgc ttgtgtttta tgtggttatt
gcaaaaaaag tatatgattc ttatagaaag 660 tccaaaagta aggacagaaa
aaacaacaaa aagctggaag gcaaagtatt tgttgtcgtg 720 gctgtcttct
ttgtgtgttt tgctccattt cattttgcca gagttccata tactcacagt 780
caaaccaaca ataagactga ctgtagactg caaaatcaac tgtttattgc taaagaaaca
840 actctctttt tggcagcaac taacatttgt atggatccct taatatacat
attcttatgt 900 aaaaaattca cagaaaagct accatgtatg caagggagaa
agaccacagc atcaagccaa 960 gaaaatcata gcagtcagac agacaacata
accttaggct ga 1002 20 333 PRT Homo sapiens 20 Met Asn Thr Thr Val
Met Gln Gly Phe Asn Arg Ser Glu Arg Cys Pro 1 5 10 15 Arg Asp Thr
Arg Ile Val Gln Leu Val Phe Pro Ala Leu Tyr Thr Val 20 25 30 Val
Phe Leu Thr Gly Ile Leu Leu Asn Thr Leu Ala Leu Trp Val Phe 35 40
45 Val His Ile Pro Ser Ser Ser Thr Phe Ile Ile Tyr Leu Lys Asn Thr
50 55 60 Leu Val Ala Asp Leu Ile Met Thr Leu Met Leu Pro Phe Lys
Ile Leu 65 70 75 80 Ser Asp Ser His Leu Ala Pro Trp Gln Leu Arg Ala
Phe Val Cys Arg 85 90 95 Phe Ser Ser Val Ile Phe Tyr Glu Thr Met
Tyr Val Gly Ile Val Leu 100 105 110 Leu Gly Leu Ile Ala Phe Asp Arg
Phe Leu Lys Ile Ile Arg Pro Leu 115 120 125 Arg Asn Ile Phe Leu Lys
Lys Pro Val Phe Ala Lys Thr Val Ser Ile 130 135 140 Phe Ile Trp Phe
Phe Leu Phe Phe Ile Ser Leu Pro Asn Thr Ile Leu 145 150 155 160 Ser
Asn Lys Glu Ala Thr Pro Ser Ser Val Lys Lys Cys Ala Ser Leu 165 170
175 Lys Gly Pro Leu Gly Leu Lys Trp His Gln Met Val Asn Asn Ile Cys
180 185 190 Gln Phe Ile Phe Trp Thr Val Phe Ile Leu Met Leu Val Phe
Tyr Val 195 200 205 Val Ile Ala Lys Lys Val Tyr Asp Ser Tyr Arg Lys
Ser Lys Ser Lys 210 215 220 Asp Arg Lys Asn Asn Lys Lys Leu Glu Gly
Lys Val Phe Val Val Val 225 230 235 240 Ala Val Phe Phe Val Cys Phe
Ala Pro Phe His Phe Ala Arg Val Pro 245 250 255 Tyr Thr His Ser Gln
Thr Asn Asn Lys Thr Asp Cys Arg Leu Gln Asn 260 265 270 Gln Leu Phe
Ile Ala Lys Glu Thr Thr Leu Phe Leu Ala Ala Thr Asn 275 280 285 Ile
Cys Met Asp Pro Leu Ile Tyr Ile Phe Leu Cys Lys Lys Phe Thr 290 295
300 Glu Lys Leu Pro Cys Met Gln Gly Arg Lys Thr Thr Ala Ser Ser Gln
305 310 315 320 Glu Asn His Ser Ser Gln Thr Asp Asn Ile Thr Leu Gly
325 330 21 1122 DNA Homo sapiens 21 atggccaaca ctaccggaga
gcctgaggag gtgagcggcg ctctgtcccc accgtccgca 60 tcagcttatg
tgaagctggt actgctggga ctgattatgt gcgtgagcct ggcgggtaac 120
gccatcttgt ccctgctggt gctcaaggag cgtgccctgc acaaggctcc ttactacttc
180 ctgctggacc tgtgcctggc cgatggcata cgctctgccg tctgcttccc
ctttgtgctg 240 gcttctgtgc gccacggctc ttcatggacc ttcagtgcac
tcagctgcaa gattgtggcc 300 tttatggccg tgctcttttg cttccatgcg
gccttcatgc tgttctgcat cagcgtcacc 360 cgctacatgg ccatcgccca
ccaccgcttc tacgccaagc gcatgacact ctggacatgc 420 gcggctgtca
tctgcatggc ctggaccctg tctgtggcca tggccttccc acctgtcttt 480
gacgtgggca cctacaagtt tattcgggag gaggaccagt gcatctttga gcatcgctac
540 ttcaaggcca atgacacgct gggcttcatg cttatgttgg ctgtgctcat
ggcagctacc 600 catgctgtct acggcaagct gctcctcttc gagtatcgtc
accgcaagat gaagccagtg 660 cagatggtgc cagccatcag ccagaactgg
acattccatg gtcccggggc caccggccag 720 gctgctgcca actggatcgc
cggctttggc cgtgggccca tgccaccaac cctgctgggt 780 atccggcaga
atgggcatgc agccagccgg cggctactgg gcatggacga ggtcaagggt 840
gaaaagcagc tgggccgcat gttctacgcg atcacactgc tctttctgct cctctggtca
900 ccctacatcg tggcctgcta ctggcgagtg tttgtgaaag cctgtgctgt
gccccaccgc 960 tacctggcca ctgctgtttg gatgagcttc gcccaggctg
ccgtcaaccc aattgtctgc 1020 ttcctgctca acaaggacct caagaagtgc
ctgaccactc acgccccctg ctggggcaca 1080 ggaggtgccc cggctcccag
agaaccctac tgtgtcatgt ga 1122 22 373 PRT Homo sapiens 22 Met Ala
Asn Thr Thr Gly Glu Pro Glu Glu Val Ser Gly Ala Leu Ser 1 5 10 15
Pro Pro Ser Ala Ser Ala Tyr Val Lys Leu Val Leu Leu Gly Leu Ile 20
25 30 Met Cys Val Ser Leu Ala Gly Asn Ala Ile Leu Ser Leu Leu Val
Leu 35 40 45 Lys Glu Arg Ala Leu His Lys Ala Pro Tyr Tyr Phe Leu
Leu Asp Leu 50 55 60 Cys Leu Ala Asp Gly Ile Arg Ser Ala Val Cys
Phe Pro Phe Val Leu 65 70 75 80 Ala Ser Val Arg His Gly Ser Ser Trp
Thr Phe Ser Ala Leu Ser Cys 85 90 95 Lys Ile Val Ala Phe Met Ala
Val Leu Phe Cys Phe His Ala Ala Phe 100 105 110 Met Leu Phe Cys Ile
Ser Val Thr Arg Tyr Met Ala Ile Ala His His 115 120 125 Arg Phe Tyr
Ala Lys Arg Met Thr Leu Trp Thr Cys Ala Ala Val Ile 130 135 140 Cys
Met Ala Trp Thr Leu Ser Val Ala Met Ala Phe Pro Pro Val Phe 145 150
155 160 Asp Val Gly Thr Tyr Lys Phe Ile Arg Glu Glu Asp Gln Cys Ile
Phe 165 170 175 Glu His Arg Tyr Phe Lys Ala Asn Asp Thr Leu Gly Phe
Met Leu Met 180 185 190 Leu Ala Val Leu Met Ala Ala Thr His Ala Val
Tyr Gly Lys Leu Leu 195 200 205 Leu Phe Glu Tyr Arg His Arg Lys Met
Lys Pro Val Gln Met Val Pro 210 215 220 Ala Ile Ser Gln Asn Trp Thr
Phe His Gly Pro Gly Ala Thr Gly Gln 225 230 235 240 Ala Ala Ala Asn
Trp Ile Ala Gly Phe Gly Arg Gly Pro Met Pro Pro 245 250 255 Thr Leu
Leu Gly Ile Arg Gln Asn Gly His Ala Ala Ser Arg Arg Leu 260 265 270
Leu Gly Met Asp Glu Val Lys Gly Glu Lys Gln Leu Gly Arg Met Phe 275
280 285 Tyr Ala Ile Thr Leu Leu Phe Leu Leu Leu Trp Ser Pro Tyr Ile
Val 290 295 300 Ala Cys Tyr Trp Arg Val Phe Val Lys Ala Cys Ala Val
Pro His Arg 305 310 315 320 Tyr Leu Ala Thr Ala Val Trp Met Ser Phe
Ala Gln Ala Ala Val Asn 325 330 335 Pro Ile Val Cys Phe Leu Leu Asn
Lys Asp Leu Lys Lys Cys Leu Thr 340 345 350 Thr His Ala Pro Cys Trp
Gly Thr Gly Gly Ala Pro Ala Pro Arg Glu 355 360 365 Pro Tyr Cys Val
Met 370 23 1053 DNA Homo sapiens 23 atggctttgg aacagaacca
gtcaacagat tattattatg aggaaaatga aatgaatggc 60 acttatgact
acagtcaata tgaattgatc tgtatcaaag aagatgtcag agaatttgca 120
aaagttttcc tccctgtatt cctcacaata gctttcgtca ttggacttgc aggcaattcc
180 atggtagtgg caatttatgc ctattacaag aaacagagaa ccaaaacaga
tgtgtacatc 240 ctgaatttgg ctgtagcaga tttactcctt ctattcactc
tgcctttttg ggctgttaat 300 gcagttcatg ggtgggtttt agggaaaata
atgtgcaaaa taacttcagc cttgtacaca 360 ctaaactttg tctctggaat
gcagtttctg gcttgcatca gcatagacag atatgtggca 420 gtaactaatg
tccccagcca atcaggagtg ggaaaaccat gctggatcat ctgtttctgt 480
gtctggatgg ctgccatctt gctgagcata ccccagctgg ttttttatac agtaaatgac
540 aatgctaggt gcattcccat tttcccccgc tacctaggaa catcaatgaa
agcattgatt 600 caaatgctag agatctgcat tggatttgta gtaccctttc
ttattatggg ggtgtgctac 660 tttatcacgg caaggacact catgaagatg
ccaaacatta aaatatctcg acccctaaaa 720 gttctgctca cagtcgttat
agttttcatt gtcactcaac tgccttataa cattgtcaag 780 ttctgccgag
ccatagacat catctactcc ctgatcacca gctgcaacat gagcaaacgc 840
atggacatcg ccatccaagt cacagaaagc attgcactct ttcacagctg cctcaaccca
900 atcctttatg tttttatggg agcatctttc aaaaactacg ttatgaaagt
ggccaagaaa 960 tatgggtcct ggagaagaca gagacaaagt gtggaggagt
ttccttttga ttctgagggt 1020 cctacagagc caaccagtac ttttagcatt taa
1053 24 350 PRT Homo sapiens 24 Met Ala Leu Glu Gln Asn Gln Ser Thr
Asp Tyr Tyr Tyr Glu Glu Asn 1 5 10 15 Glu Met Asn Gly Thr Tyr Asp
Tyr Ser Gln Tyr Glu Leu Ile Cys Ile 20 25 30 Lys Glu Asp Val Arg
Glu Phe Ala Lys Val Phe Leu Pro Val Phe Leu 35 40 45 Thr Ile Ala
Phe Val Ile Gly Leu Ala Gly Asn Ser Met Val Val Ala 50 55 60 Ile
Tyr Ala Tyr Tyr Lys Lys Gln Arg Thr Lys Thr Asp Val Tyr Ile 65 70
75 80 Leu Asn Leu Ala Val Ala Asp Leu Leu Leu Leu Phe Thr Leu Pro
Phe 85 90 95 Trp Ala Val Asn Ala Val His Gly Trp Val Leu Gly Lys
Ile Met Cys 100 105 110 Lys Ile Thr Ser Ala Leu Tyr Thr Leu Asn Phe
Val Ser Gly Met Gln 115 120 125 Phe Leu Ala Cys Ile Ser Ile Asp Arg
Tyr Val Ala Val Thr Asn Val 130 135 140 Pro Ser Gln Ser Gly Val Gly
Lys Pro Cys Trp Ile Ile Cys Phe Cys 145 150 155 160 Val Trp Met Ala
Ala Ile Leu Leu Ser Ile Pro Gln Leu Val Phe Tyr 165 170 175 Thr Val
Asn Asp Asn Ala Arg Cys Ile Pro Ile Phe Pro Arg Tyr Leu 180 185 190
Gly Thr Ser Met Lys Ala Leu Ile Gln Met Leu Glu Ile Cys Ile Gly 195
200 205 Phe Val Val Pro Phe Leu Ile Met Gly Val Cys Tyr Phe Ile Thr
Ala 210 215 220 Arg Thr Leu Met Lys Met Pro Asn Ile Lys Ile Ser Arg
Pro Leu Lys 225 230 235 240 Val Leu Leu Thr Val Val Ile Val Phe Ile
Val Thr Gln Leu Pro Tyr 245 250 255 Asn Ile Val Lys Phe Cys Arg Ala
Ile Asp Ile Ile Tyr Ser Leu Ile 260 265 270 Thr Ser Cys Asn Met Ser
Lys Arg Met Asp Ile Ala Ile Gln Val Thr 275 280 285 Glu Ser Ile Ala
Leu Phe His Ser Cys Leu Asn Pro Ile Leu Tyr Val 290 295 300 Phe Met
Gly Ala Ser Phe Lys Asn Tyr Val Met Lys Val Ala Lys Lys 305 310 315
320 Tyr Gly Ser Trp Arg Arg Gln Arg Gln Ser Val Glu Glu Phe Pro Phe
325 330 335 Asp Ser Glu Gly Pro Thr Glu Pro Thr Ser Thr Phe Ser Ile
340 345 350 25 1116 DNA Homo sapiens 25 atgccaggaa acgccacccc
agtgaccacc actgccccgt gggcctccct gggcctctcc 60 gccaagacct
gcaacaacgt gtccttcgaa gagagcagga tagtcctggt cgtggtgtac 120
agcgcggtgt gcacgctggg ggtgccggcc aactgcctga ctgcgtggct ggcgctgctg
180 caggtactgc agggcaacgt gctggccgtc tacctgctct gcctggcact
ctgcgaactg 240 ctgtacacag gcacgctgcc actctgggtc atctatatcc
gcaaccagca ccgctggacc 300 ctaggcctgc tggcctcgaa ggtgaccgcc
tacatcttct tctgcaacat ctacgtcagc 360 atcctcttcc tgtgctgcat
ctcctgcgac cgcttcgtgg ccgtggtgta cgcgctggag 420 agtcggggcc
gccgccgccg gaggaccgcc atcctcatct ccgcctgcat cttcatcctc 480
gtcgggatcg ttcactaccc ggtgttccag acggaagaca aggagacctg ctttgacatg
540 ctgcagatgg acagcaggat tgccgggtac tactacgcca ggttcaccgt
tggctttgcc 600 atccctctct ccatcatcgc cttcaccaac caccggattt
tcaggagcat caagcagagc 660 atgggcttaa gcgctgccca gaaggccaag
gtgaagcact cggccatcgc ggtggttgtc 720 atcttcctag tctgcttcgc
cccgtaccac ctggttctcc tcgtcaaagc cgctgccttt 780 tcctactaca
gaggagacag gaacgccatg tgcggcttgg aggaaaggct gtacacagcc 840
tctgtggtgt ttctgtgcct gtccacggtg aacggcgtgg ctgaccccat tatctacgtg
900 ctggccacgg accattcccg ccaagaagtg tccagaatcc ataaggggtg
gaaagagtgg 960 tccatgaaga cagacgtcac caggctcacc cacagcaggg
acaccgagga gctgcagtcg 1020 cccgtggccc ttgcagacca ctacaccttc
tccaggcccg tgcacccacc agggtcacca 1080 tgccctgcaa agaggctgat
tgaggagtcc tgctga 1116 26 371 PRT Homo sapiens 26 Met Pro Gly Asn
Ala Thr Pro Val Thr Thr Thr Ala Pro Trp Ala Ser 1 5 10 15 Leu Gly
Leu Ser Ala Lys Thr Cys Asn Asn Val Ser Phe Glu Glu Ser 20 25 30
Arg Ile Val Leu Val Val Val Tyr Ser Ala Val Cys Thr Leu Gly Val 35
40 45 Pro Ala Asn Cys Leu Thr Ala Trp Leu Ala Leu Leu Gln Val Leu
Gln 50 55 60 Gly Asn Val Leu Ala Val Tyr Leu Leu Cys Leu Ala Leu
Cys Glu Leu 65 70 75 80 Leu Tyr Thr Gly Thr Leu Pro Leu Trp Val Ile
Tyr Ile Arg Asn Gln 85 90 95 His Arg Trp Thr Leu Gly Leu Leu Ala
Ser Lys Val Thr Ala Tyr Ile 100 105 110 Phe Phe Cys Asn Ile Tyr Val
Ser Ile Leu Phe Leu Cys Cys Ile Ser 115 120 125 Cys Asp Arg Phe Val
Ala Val Val Tyr Ala Leu Glu Ser Arg Gly Arg 130 135 140 Arg Arg Arg
Arg Thr Ala Ile Leu Ile Ser Ala Cys Ile Phe Ile Leu 145 150 155 160
Val Gly Ile Val His Tyr Pro Val Phe Gln Thr Glu Asp Lys Glu Thr 165
170 175 Cys Phe Asp Met Leu Gln Met Asp Ser Arg Ile Ala Gly Tyr Tyr
Tyr 180 185 190 Ala Arg Phe Thr Val Gly Phe Ala Ile Pro Leu Ser Ile
Ile Ala Phe 195 200 205 Thr Asn His Arg Ile Phe Arg Ser Ile Lys Gln
Ser Met Gly Leu Ser 210 215 220 Ala Ala Gln Lys Ala Lys Val Lys His
Ser Ala Ile Ala Val Val Val 225 230 235 240 Ile Phe Leu Val Cys Phe
Ala Pro Tyr His Leu Val Leu Leu Val Lys 245 250 255 Ala Ala Ala Phe
Ser Tyr Tyr Arg Gly Asp Arg Asn Ala Met Cys Gly 260 265 270 Leu Glu
Glu Arg Leu Tyr Thr Ala Ser Val Val Phe Leu Cys Leu Ser 275 280 285
Thr Val Asn Gly Val Ala Asp Pro Ile Ile Tyr Val Leu Ala Thr Asp 290
295 300 His Ser Arg Gln Glu Val Ser Arg Ile His Lys Gly Trp Lys Glu
Trp 305 310 315 320 Ser Met Lys Thr Asp Val Thr Arg Leu Thr His Ser
Arg Asp Thr Glu 325 330 335 Glu Leu Gln Ser Pro Val Ala Leu Ala Asp
His Tyr Thr Phe Ser Arg 340 345 350 Pro Val His Pro Pro Gly Ser Pro
Cys Pro Ala Lys Arg Leu Ile Glu 355 360 365 Glu Ser Cys 370 27 1113
DNA Homo sapiens 27 atggcgaact atagccatgc agctgacaac attttgcaaa
atctctcgcc tctaacagcc 60 tttctgaaac tgacttcctt gggtttcata
ataggagtca gcgtggtggg caacctcctg 120 atctccattt tgctagtgaa
agataagacc ttgcatagag caccttacta cttcctgttg 180 gatctttgct
gttcagatat cctcagatct gcaatttgtt tcccatttgt gttcaactct 240
gtcaaaaatg gctctacctg gacttatggg actctgactt gcaaagtgat tgcctttctg
300 ggggttttgt cctgtttcca cactgctttc atgctcttct gcatcagtgt
caccagatac 360 ttagctatcg cccatcaccg cttctataca aagaggctga
ccttttggac gtgtctggct 420 gtgatctgta tggtgtggac tctgtctgtg
gccatggcat ttcccccggt tttagacgtg 480 ggcacttact cattcattag
ggaggaagat caatgcacct tccaacaccg ctccttcagg 540 gctaatgatt
ccttaggatt tatgctgctt cttgctctca tcctcctagc cacacagctt 600
gtctacctca agctgatatt tttcgtccac gatcgaagaa aaatgaagcc agtccagttt
660 gtagcagcag tcagccagaa ctggactttt catggtcctg gagccagtgg
ccaggcagct 720 gccaattggc tagcaggatt tggaaggggt cccacaccac
ccaccttgct gggcatcagg 780 caaaatgcaa acaccacagg cagaagaagg
ctattggtct tagacgagtt caaaatggag 840 aaaagaatca gcagaatgtt
ctatataatg acttttctgt ttctaacctt gtggggcccc 900 tacctggtgg
cctgttattg gagagttttt gcaagagggc ctgtagtacc agggggattt 960
ctaacagctg ctgtctggat gagttttgcc caagcaggaa tcaatccttt tgtctgcatt
1020 ttctcaaaca gggagctgag gcgctgtttc agcacaaccc ttctttactg
cagaaaatcc 1080 aggttaccaa gggaacctta ctgtgttata tga 1113 28 370
PRT Homo sapiens 28 Met Ala Asn Tyr Ser His Ala Ala Asp Asn Ile Leu
Gln Asn Leu Ser 1 5 10 15 Pro Leu Thr Ala Phe Leu Lys Leu Thr Ser
Leu Gly Phe Ile Ile Gly 20 25 30 Val Ser Val Val Gly Asn Leu Leu
Ile Ser Ile Leu Leu Val Lys Asp 35 40 45 Lys Thr Leu His Arg Ala
Pro Tyr Tyr Phe Leu Leu Asp Leu Cys Cys 50 55 60 Ser Asp Ile Leu
Arg Ser Ala Ile Cys Phe Pro Phe Val Phe Asn Ser 65 70 75 80 Val Lys
Asn Gly Ser Thr Trp Thr Tyr Gly Thr Leu Thr Cys Lys Val 85 90 95
Ile Ala Phe Leu Gly Val Leu Ser Cys Phe His Thr Ala Phe Met Leu 100
105 110 Phe Cys Ile Ser Val Thr Arg Tyr Leu Ala Ile Ala His His Arg
Phe 115 120 125 Tyr Thr Lys Arg Leu Thr Phe Trp Thr Cys Leu Ala Val
Ile Cys Met 130 135 140 Val Trp Thr Leu Ser Val Ala Met Ala Phe Pro
Pro Val Leu Asp Val 145 150 155 160 Gly Thr Tyr Ser Phe Ile Arg Glu
Glu Asp Gln Cys Thr Phe Gln His 165 170 175 Arg Ser Phe Arg Ala Asn
Asp Ser Leu Gly Phe Met Leu Leu Leu Ala 180 185 190
Leu Ile Leu Leu Ala Thr Gln Leu Val Tyr Leu Lys Leu Ile Phe Phe 195
200 205 Val His Asp Arg Arg Lys Met Lys Pro Val Gln Phe Val Ala Ala
Val 210 215 220 Ser Gln Asn Trp Thr Phe His Gly Pro Gly Ala Ser Gly
Gln Ala Ala 225 230 235 240 Ala Asn Trp Leu Ala Gly Phe Gly Arg Gly
Pro Thr Pro Pro Thr Leu 245 250 255 Leu Gly Ile Arg Gln Asn Ala Asn
Thr Thr Gly Arg Arg Arg Leu Leu 260 265 270 Val Leu Asp Glu Phe Lys
Met Glu Lys Arg Ile Ser Arg Met Phe Tyr 275 280 285 Ile Met Thr Phe
Leu Phe Leu Thr Leu Trp Gly Pro Tyr Leu Val Ala 290 295 300 Cys Tyr
Trp Arg Val Phe Ala Arg Gly Pro Val Val Pro Gly Gly Phe 305 310 315
320 Leu Thr Ala Ala Val Trp Met Ser Phe Ala Gln Ala Gly Ile Asn Pro
325 330 335 Phe Val Cys Ile Phe Ser Asn Arg Glu Leu Arg Arg Cys Phe
Ser Thr 340 345 350 Thr Leu Leu Tyr Cys Arg Lys Ser Arg Leu Pro Arg
Glu Pro Tyr Cys 355 360 365 Val Ile 370 29 1080 DNA Homo sapiens 29
atgcaggtcc cgaacagcac cggcccggac aacgcgacgc tgcagatgct gcggaacccg
60 gcgatcgcgg tggccctgcc cgtggtgtac tcgctggtgg cggcggtcag
catcccgggc 120 aacctcttct ctctgtgggt gctgtgccgg cgcatggggc
ccagatcccc gtcggtcatc 180 ttcatgatca acctgagcgt cacggacctg
atgctggcca gcgtgttgcc tttccaaatc 240 tactaccatt gcaaccgcca
ccactgggta ttcggggtgc tgctttgcaa cgtggtgacc 300 gtggcctttt
acgcaaacat gtattccagc atcctcacca tgacctgtat cagcgtggag 360
cgcttcctgg gggtcctgta cccgctcagc tccaagcgct ggcgccgccg tcgttacgcg
420 gtggccgcgt gtgcagggac ctggctgctg ctcctgaccg ccctgtgccc
gctggcgcgc 480 accgatctca cctacccggt gcacgccctg ggcatcatca
cctgcttcga cgtcctcaag 540 tggacgatgc tccccagcgt ggccatgtgg
gccgtgttcc tcttcaccat cttcatcctg 600 ctgttcctca tcccgttcgt
gatcaccgtg gcttgttaca cggccaccat cctcaagctg 660 ttgcgcacgg
aggaggcgca cggccgggag cagcggaggc gcgcggtggg cctggccgcg 720
gtggtcttgc tggcctttgt cacctgcttc gcccccaaca acttcgtgct cctggcgcac
780 atcgtgagcc gcctgttcta cggcaagagc tactaccacg tgtacaagct
cacgctgtgt 840 ctcagctgcc tcaacaactg tctggacccg tttgtttatt
actttgcgtc ccgggaattc 900 cagctgcgcc tgcgggaata tttgggctgc
cgccgggtgc ccagagacac cctggacacg 960 cgccgcgaga gcctcttctc
cgccaggacc acgtccgtgc gctccgaggc cggtgcgcac 1020 cctgaaggga
tggagggagc caccaggccc ggcctccaga ggcaggagag tgtgttctga 1080 30 359
PRT Homo sapiens 30 Met Gln Val Pro Asn Ser Thr Gly Pro Asp Asn Ala
Thr Leu Gln Met 1 5 10 15 Leu Arg Asn Pro Ala Ile Ala Val Ala Leu
Pro Val Val Tyr Ser Leu 20 25 30 Val Ala Ala Val Ser Ile Pro Gly
Asn Leu Phe Ser Leu Trp Val Leu 35 40 45 Cys Arg Arg Met Gly Pro
Arg Ser Pro Ser Val Ile Phe Met Ile Asn 50 55 60 Leu Ser Val Thr
Asp Leu Met Leu Ala Ser Val Leu Pro Phe Gln Ile 65 70 75 80 Tyr Tyr
His Cys Asn Arg His His Trp Val Phe Gly Val Leu Leu Cys 85 90 95
Asn Val Val Thr Val Ala Phe Tyr Ala Asn Met Tyr Ser Ser Ile Leu 100
105 110 Thr Met Thr Cys Ile Ser Val Glu Arg Phe Leu Gly Val Leu Tyr
Pro 115 120 125 Leu Ser Ser Lys Arg Trp Arg Arg Arg Arg Tyr Ala Val
Ala Ala Cys 130 135 140 Ala Gly Thr Trp Leu Leu Leu Leu Thr Ala Leu
Cys Pro Leu Ala Arg 145 150 155 160 Thr Asp Leu Thr Tyr Pro Val His
Ala Leu Gly Ile Ile Thr Cys Phe 165 170 175 Asp Val Leu Lys Trp Thr
Met Leu Pro Ser Val Ala Met Trp Ala Val 180 185 190 Phe Leu Phe Thr
Ile Phe Ile Leu Leu Phe Leu Ile Pro Phe Val Ile 195 200 205 Thr Val
Ala Cys Tyr Thr Ala Thr Ile Leu Lys Leu Leu Arg Thr Glu 210 215 220
Glu Ala His Gly Arg Glu Gln Arg Arg Arg Ala Val Gly Leu Ala Ala 225
230 235 240 Val Val Leu Leu Ala Phe Val Thr Cys Phe Ala Pro Asn Asn
Phe Val 245 250 255 Leu Leu Ala His Ile Val Ser Arg Leu Phe Tyr Gly
Lys Ser Tyr Tyr 260 265 270 His Val Tyr Lys Leu Thr Leu Cys Leu Ser
Cys Leu Asn Asn Cys Leu 275 280 285 Asp Pro Phe Val Tyr Tyr Phe Ala
Ser Arg Glu Phe Gln Leu Arg Leu 290 295 300 Arg Glu Tyr Leu Gly Cys
Arg Arg Val Pro Arg Asp Thr Leu Asp Thr 305 310 315 320 Arg Arg Glu
Ser Leu Phe Ser Ala Arg Thr Thr Ser Val Arg Ser Glu 325 330 335 Ala
Gly Ala His Pro Glu Gly Met Glu Gly Ala Thr Arg Pro Gly Leu 340 345
350 Gln Arg Gln Glu Ser Val Phe 355 31 1503 DNA Homo sapiens 31
atggagcgtc cctgggagga cagcccaggc ccggaggggg cagctgaggg ctcgcctgtg
60 ccagtcgccg ccggggcgcg ctccggtgcc gcggcgagtg gcacaggctg
gcagccatgg 120 gctgagtgcc cgggacccaa ggggaggggg caactgctgg
cgaccgccgg ccctttgcgt 180 cgctggcccg ccccctcgcc tgccagctcc
agccccgccc ccggagcggc gtccgctcac 240 tcggttcaag gcagcgcgac
tgcgggtggc gcacgaccag ggcgcagacc ttggggcgcg 300 cggcccatgg
agtcggggct gctgcggccg gcgccggtga gcgaggtcat cgtcctgcat 360
tacaactaca ccggcaagct ccgcggtgcg agctaccagc cgggtgccgg cctgcgcgcc
420 gacgccgtgg tgtgcctggc ggtgtgcgcc ttcatcgtgc tagagaatct
agccgtgttg 480 ttggtgctcg gacgccaccc gcgcttccac gctcccatgt
tcctgctcct gggcagcctc 540 acgttgtcgg atctgctggc aggcgccgcc
tacgccgcca acatcctact gtcggggccg 600 ctcacgctga aactgtcccc
cgcgctctgg ttcgcacggg agggaggcgt cttcgtggca 660 ctcactgcgt
ccgtgctgag cctcctggcc atcgcgctgg agcgcagcct caccatggcg 720
cgcagggggc ccgcgcccgt ctccagtcgg gggcgcacgc tggcgatggc agccgcggcc
780 tggggcgtgt cgctgctcct cgggctcctg ccagcgctgg gctggaattg
cctgggtcgc 840 ctggacgctt gctccactgt cttgccgctc tacgccaagg
cctacgtgct cttctgcgtg 900 ctcgccttcg tgggcatcct ggccgcgatc
tgtgcactct acgcgcgcat ctactgccag 960 gtacgcgcca acgcgcggcg
cctgccggca cggcccggga ctgcggggac cacctcgacc 1020 cgggcgcgtc
gcaagccgcg ctctctggcc ttgctgcgca cgctcagcgt ggtgctcctg 1080
gcctttgtgg catgttgggg ccccctcttc ctgctgctgt tgctcgacgt ggcgtgcccg
1140 gcgcgcacct gtcctgtact cctgcaggcc gatcccttcc tgggactggc
catggccaac 1200 tcacttctga accccatcat ctacacgctc accaaccgcg
acctgcgcca cgcgctcctg 1260 cgcctggtct gctgcggacg ccactcctgc
ggcagagacc cgagtggctc ccagcagtcg 1320 gcgagcgcgg ctgaggcttc
cgggggcctg cgccgctgcc tgcccccggg ccttgatggg 1380 agcttcagcg
gctcggagcg ctcatcgccc cagcgcgacg ggctggacac cagcggctcc 1440
acaggcagcc ccggtgcacc cacagccgcc cggactctgg tatcagaacc ggctgcagac
1500 tga 1503 32 500 PRT Homo sapiens 32 Met Glu Arg Pro Trp Glu
Asp Ser Pro Gly Pro Glu Gly Ala Ala Glu 1 5 10 15 Gly Ser Pro Val
Pro Val Ala Ala Gly Ala Arg Ser Gly Ala Ala Ala 20 25 30 Ser Gly
Thr Gly Trp Gln Pro Trp Ala Glu Cys Pro Gly Pro Lys Gly 35 40 45
Arg Gly Gln Leu Leu Ala Thr Ala Gly Pro Leu Arg Arg Trp Pro Ala 50
55 60 Pro Ser Pro Ala Ser Ser Ser Pro Ala Pro Gly Ala Ala Ser Ala
His 65 70 75 80 Ser Val Gln Gly Ser Ala Thr Ala Gly Gly Ala Arg Pro
Gly Arg Arg 85 90 95 Pro Trp Gly Ala Arg Pro Met Glu Ser Gly Leu
Leu Arg Pro Ala Pro 100 105 110 Val Ser Glu Val Ile Val Leu His Tyr
Asn Tyr Thr Gly Lys Leu Arg 115 120 125 Gly Ala Ser Tyr Gln Pro Gly
Ala Gly Leu Arg Ala Asp Ala Val Val 130 135 140 Cys Leu Ala Val Cys
Ala Phe Ile Val Leu Glu Asn Leu Ala Val Leu 145 150 155 160 Leu Val
Leu Gly Arg His Pro Arg Phe His Ala Pro Met Phe Leu Leu 165 170 175
Leu Gly Ser Leu Thr Leu Ser Asp Leu Leu Ala Gly Ala Ala Tyr Ala 180
185 190 Ala Asn Ile Leu Leu Ser Gly Pro Leu Thr Leu Lys Leu Ser Pro
Ala 195 200 205 Leu Trp Phe Ala Arg Glu Gly Gly Val Phe Val Ala Leu
Thr Ala Ser 210 215 220 Val Leu Ser Leu Leu Ala Ile Ala Leu Glu Arg
Ser Leu Thr Met Ala 225 230 235 240 Arg Arg Gly Pro Ala Pro Val Ser
Ser Arg Gly Arg Thr Leu Ala Met 245 250 255 Ala Ala Ala Ala Trp Gly
Val Ser Leu Leu Leu Gly Leu Leu Pro Ala 260 265 270 Leu Gly Trp Asn
Cys Leu Gly Arg Leu Asp Ala Cys Ser Thr Val Leu 275 280 285 Pro Leu
Tyr Ala Lys Ala Tyr Val Leu Phe Cys Val Leu Ala Phe Val 290 295 300
Gly Ile Leu Ala Ala Ile Cys Ala Leu Tyr Ala Arg Ile Tyr Cys Gln 305
310 315 320 Val Arg Ala Asn Ala Arg Arg Leu Pro Ala Arg Pro Gly Thr
Ala Gly 325 330 335 Thr Thr Ser Thr Arg Ala Arg Arg Lys Pro Arg Ser
Leu Ala Leu Leu 340 345 350 Arg Thr Leu Ser Val Val Leu Leu Ala Phe
Val Ala Cys Trp Gly Pro 355 360 365 Leu Phe Leu Leu Leu Leu Leu Asp
Val Ala Cys Pro Ala Arg Thr Cys 370 375 380 Pro Val Leu Leu Gln Ala
Asp Pro Phe Leu Gly Leu Ala Met Ala Asn 385 390 395 400 Ser Leu Leu
Asn Pro Ile Ile Tyr Thr Leu Thr Asn Arg Asp Leu Arg 405 410 415 His
Ala Leu Leu Arg Leu Val Cys Cys Gly Arg His Ser Cys Gly Arg 420 425
430 Asp Pro Ser Gly Ser Gln Gln Ser Ala Ser Ala Ala Glu Ala Ser Gly
435 440 445 Gly Leu Arg Arg Cys Leu Pro Pro Gly Leu Asp Gly Ser Phe
Ser Gly 450 455 460 Ser Glu Arg Ser Ser Pro Gln Arg Asp Gly Leu Asp
Thr Ser Gly Ser 465 470 475 480 Thr Gly Ser Pro Gly Ala Pro Thr Ala
Ala Arg Thr Leu Val Ser Glu 485 490 495 Pro Ala Ala Asp 500 33 1029
DNA Homo sapiens 33 atgcaagccg tcgacaatct cacctctgcg cctgggaaca
ccagtctgtg caccagagac 60 tacaaaatca cccaggtcct cttcccactg
ctctacactg tcctgttttt tgttggactt 120 atcacaaatg gcctggcgat
gaggattttc tttcaaatcc ggagtaaatc aaactttatt 180 atttttctta
agaacacagt catttctgat cttctcatga ttctgacttt tccattcaaa 240
attcttagtg atgccaaact gggaacagga ccactgagaa cttttgtgtg tcaagttacc
300 tccgtcatat tttatttcac aatgtatatc agtatttcat tcctgggact
gataactatc 360 gatcgctacc agaagaccac caggccattt aaaacatcca
accccaaaaa tctcttgggg 420 gctaagattc tctctgttgt catctgggca
ttcatgttct tactctcttt gcctaacatg 480 attctgacca acaggcagcc
gagagacaag aatgtgaaga aatgctcttt ccttaaatca 540 gagttcggtc
tagtctggca tgaaatagta aattacatct gtcaagtcat tttctggatt 600
aatttcttaa ttgttattgt atgttataca ctcattacaa aagaactgta ccggtcatac
660 gtaagaacga ggggtgtagg taaagtcccc aggaaaaagg tgaacgtcaa
agttttcatt 720 atcattgctg tattctttat ttgttttgtt cctttccatt
ttgcccgaat tccttacacc 780 ctgagccaaa cccgggatgt ctttgactgc
actgctgaaa atactctgtt ctatgtgaaa 840 gagagcactc tgtggttaac
ttccttaaat gcatgcctgg atccgttcat ctattttttc 900 ctttgcaagt
ccttcagaaa ttccttgata agtatgctga agtgccccaa ttctgcaaca 960
tctctgtccc aggacaatag gaaaaaagaa caggatggtg gtgacccaaa tgaagagact
1020 ccaatgtaa 1029 34 342 PRT Homo sapiens 34 Met Gln Ala Val Asp
Asn Leu Thr Ser Ala Pro Gly Asn Thr Ser Leu 1 5 10 15 Cys Thr Arg
Asp Tyr Lys Ile Thr Gln Val Leu Phe Pro Leu Leu Tyr 20 25 30 Thr
Val Leu Phe Phe Val Gly Leu Ile Thr Asn Gly Leu Ala Met Arg 35 40
45 Ile Phe Phe Gln Ile Arg Ser Lys Ser Asn Phe Ile Ile Phe Leu Lys
50 55 60 Asn Thr Val Ile Ser Asp Leu Leu Met Ile Leu Thr Phe Pro
Phe Lys 65 70 75 80 Ile Leu Ser Asp Ala Lys Leu Gly Thr Gly Pro Leu
Arg Thr Phe Val 85 90 95 Cys Gln Val Thr Ser Val Ile Phe Tyr Phe
Thr Met Tyr Ile Ser Ile 100 105 110 Ser Phe Leu Gly Leu Ile Thr Ile
Asp Arg Tyr Gln Lys Thr Thr Arg 115 120 125 Pro Phe Lys Thr Ser Asn
Pro Lys Asn Leu Leu Gly Ala Lys Ile Leu 130 135 140 Ser Val Val Ile
Trp Ala Phe Met Phe Leu Leu Ser Leu Pro Asn Met 145 150 155 160 Ile
Leu Thr Asn Arg Gln Pro Arg Asp Lys Asn Val Lys Lys Cys Ser 165 170
175 Phe Leu Lys Ser Glu Phe Gly Leu Val Trp His Glu Ile Val Asn Tyr
180 185 190 Ile Cys Gln Val Ile Phe Trp Ile Asn Phe Leu Ile Val Ile
Val Cys 195 200 205 Tyr Thr Leu Ile Thr Lys Glu Leu Tyr Arg Ser Tyr
Val Arg Thr Arg 210 215 220 Gly Val Gly Lys Val Pro Arg Lys Lys Val
Asn Val Lys Val Phe Ile 225 230 235 240 Ile Ile Ala Val Phe Phe Ile
Cys Phe Val Pro Phe His Phe Ala Arg 245 250 255 Ile Pro Tyr Thr Leu
Ser Gln Thr Arg Asp Val Phe Asp Cys Thr Ala 260 265 270 Glu Asn Thr
Leu Phe Tyr Val Lys Glu Ser Thr Leu Trp Leu Thr Ser 275 280 285 Leu
Asn Ala Cys Leu Asp Pro Phe Ile Tyr Phe Phe Leu Cys Lys Ser 290 295
300 Phe Arg Asn Ser Leu Ile Ser Met Leu Lys Cys Pro Asn Ser Ala Thr
305 310 315 320 Ser Leu Ser Gln Asp Asn Arg Lys Lys Glu Gln Asp Gly
Gly Asp Pro 325 330 335 Asn Glu Glu Thr Pro Met 340 35 1077 DNA
Homo sapiens 35 atgtcggtct gctaccgtcc cccagggaac gagacactgc
tgagctggaa gacttcgcgg 60 gccacaggca cagccttcct gctgctggcg
gcgctgctgg ggctgcctgg caacggcttc 120 gtggtgtgga gcttggcggg
ctggcggcct gcacgggggc gaccgctggc ggccacgctt 180 gtgctgcacc
tggcgctggc cgacggcgcg gtgctgctgc tcacgccgct ctttgtggcc 240
ttcctgaccc ggcaggcctg gccgctgggc caggcgggct gcaaggcggt gtactacgtg
300 tgcgcgctca gcatgtacgc cagcgtgctg ctcaccggcc tgctcagcct
gcagcgctgc 360 ctcgcagtca cccgcccctt cctggcgcct cggctgcgca
gcccggccct ggcccgccgc 420 ctgctgctgg cggtctggct ggccgccctg
ttgctcgccg tcccggccgc cgtctaccgc 480 cacctgtgga gggaccgcgt
atgccagctg tgccacccgt cgccggtcca cgccgccgcc 540 cacctgagcc
tggagactct gaccgctttc gtgcttcctt tcgggctgat gctcggctgc 600
tacagcgtga cgctggcacg gctgcggggc gcccgctggg gctccgggcg gcacggggcg
660 cgggtgggcc ggctggtgag cgccatcgtg cttgccttcg gcttgctctg
ggccccctac 720 cacgcagtca accttctgca ggcggtcgca gcgctggctc
caccggaagg ggccttggcg 780 aagctgggcg gagccggcca ggcggcgcga
gcgggaacta cggccttggc cttcttcagt 840 tctagcgtca acccggtgct
ctacgtcttc accgctggag atctgctgcc ccgggcaggt 900 ccccgtttcc
tcacgcggct cttcgaaggc tctggggagg cccgaggggg cggccgctct 960
agggaaggga ccatggagct ccgaactacc cctcagctga aagtggtggg gcagggccgc
1020 ggcaatggag acccgggggg tgggatggag aaggacggtc cggaatggga cctttga
1077 36 358 PRT Homo sapiens 36 Met Ser Val Cys Tyr Arg Pro Pro Gly
Asn Glu Thr Leu Leu Ser Trp 1 5 10 15 Lys Thr Ser Arg Ala Thr Gly
Thr Ala Phe Leu Leu Leu Ala Ala Leu 20 25 30 Leu Gly Leu Pro Gly
Asn Gly Phe Val Val Trp Ser Leu Ala Gly Trp 35 40 45 Arg Pro Ala
Arg Gly Arg Pro Leu Ala Ala Thr Leu Val Leu His Leu 50 55 60 Ala
Leu Ala Asp Gly Ala Val Leu Leu Leu Thr Pro Leu Phe Val Ala 65 70
75 80 Phe Leu Thr Arg Gln Ala Trp Pro Leu Gly Gln Ala Gly Cys Lys
Ala 85 90 95 Val Tyr Tyr Val Cys Ala Leu Ser Met Tyr Ala Ser Val
Leu Leu Thr 100 105 110 Gly Leu Leu Ser Leu Gln Arg Cys Leu Ala Val
Thr Arg Pro Phe Leu 115 120 125 Ala Pro Arg Leu Arg Ser Pro Ala Leu
Ala Arg Arg Leu Leu Leu Ala 130 135 140 Val Trp Leu Ala Ala Leu Leu
Leu Ala Val Pro Ala Ala Val Tyr Arg 145 150 155 160 His Leu Trp Arg
Asp Arg Val Cys Gln Leu Cys His Pro Ser Pro Val 165 170 175 His Ala
Ala Ala His Leu Ser Leu Glu Thr Leu Thr Ala Phe Val Leu 180 185 190
Pro Phe Gly Leu Met Leu Gly Cys Tyr Ser Val Thr Leu Ala Arg Leu 195
200 205 Arg Gly Ala Arg Trp Gly Ser Gly Arg His Gly Ala Arg Val Gly
Arg 210 215 220 Leu Val Ser Ala Ile Val Leu Ala Phe Gly Leu Leu Trp
Ala Pro Tyr 225 230 235 240 His Ala Val Asn Leu Leu Gln Ala Val Ala
Ala Leu Ala Pro Pro Glu 245 250 255 Gly
Ala Leu Ala Lys Leu Gly Gly Ala Gly Gln Ala Ala Arg Ala Gly 260 265
270 Thr Thr Ala Leu Ala Phe Phe Ser Ser Ser Val Asn Pro Val Leu Tyr
275 280 285 Val Phe Thr Ala Gly Asp Leu Leu Pro Arg Ala Gly Pro Arg
Phe Leu 290 295 300 Thr Arg Leu Phe Glu Gly Ser Gly Glu Ala Arg Gly
Gly Gly Arg Ser 305 310 315 320 Arg Glu Gly Thr Met Glu Leu Arg Thr
Thr Pro Gln Leu Lys Val Val 325 330 335 Gly Gln Gly Arg Gly Asn Gly
Asp Pro Gly Gly Gly Met Glu Lys Asp 340 345 350 Gly Pro Glu Trp Asp
Leu 355 37 1005 DNA Homo sapiens 37 atgctgggga tcatggcatg
gaatgcaact tgcaaaaact ggctggcagc agaggctgcc 60 ctggaaaagt
actacctttc cattttttat gggattgagt tcgttgtggg agtccttgga 120
aataccattg ttgtttacgg ctacatcttc tctctgaaga actggaacag cagtaatatt
180 tatctcttta acctctctgt ctctgactta gcttttctgt gcaccctccc
catgctgata 240 aggagttatg ccaatggaaa ctggatatat ggagacgtgc
tctgcataag caaccgatat 300 gtgcttcatg ccaacctcta taccagcatt
ctctttctca cttttatcag catagatcga 360 tacttgataa ttaagtatcc
tttccgagaa caccttctgc aaaagaaaga gtttgctatt 420 ttaatctcct
tggccatttg ggttttagta accttagagt tactacccat acttcccctt 480
ataaatcctg ttataactga caatggcacc acctgtaatg attttgcaag ttctggagac
540 cccaactaca acctcattta cagcatgtgt ctaacactgt tggggttcct
tattcctctt 600 tttgtgatgt gtttctttta ttacaagatt gctctcttcc
taaagcagag gaataggcag 660 gttgctactg ctctgcccct tgaaaagcct
ctcaacttgg tcatcatggc agtggtaatc 720 ttctctgtgc tttttacacc
ctatcacgtc atgcggaatg tgaggatcgc ttcacgcctg 780 gggagttgga
agcagtatca gtgcactcag gtcgtcatca actcctttta cattgtgaca 840
cggcctttgg cctttctgaa cagtgtcatc aaccctgtct tctattttct tttgggagat
900 cacttcaggg acatgctgat gaatcaactg agacacaact tcaaatccct
tacatccttt 960 agcagatggg ctcatgaact cctactttca ttcagagaaa agtga
1005 38 334 PRT Homo sapiens 38 Met Leu Gly Ile Met Ala Trp Asn Ala
Thr Cys Lys Asn Trp Leu Ala 1 5 10 15 Ala Glu Ala Ala Leu Glu Lys
Tyr Tyr Leu Ser Ile Phe Tyr Gly Ile 20 25 30 Glu Phe Val Val Gly
Val Leu Gly Asn Thr Ile Val Val Tyr Gly Tyr 35 40 45 Ile Phe Ser
Leu Lys Asn Trp Asn Ser Ser Asn Ile Tyr Leu Phe Asn 50 55 60 Leu
Ser Val Ser Asp Leu Ala Phe Leu Cys Thr Leu Pro Met Leu Ile 65 70
75 80 Arg Ser Tyr Ala Asn Gly Asn Trp Ile Tyr Gly Asp Val Leu Cys
Ile 85 90 95 Ser Asn Arg Tyr Val Leu His Ala Asn Leu Tyr Thr Ser
Ile Leu Phe 100 105 110 Leu Thr Phe Ile Ser Ile Asp Arg Tyr Leu Ile
Ile Lys Tyr Pro Phe 115 120 125 Arg Glu His Leu Leu Gln Lys Lys Glu
Phe Ala Ile Leu Ile Ser Leu 130 135 140 Ala Ile Trp Val Leu Val Thr
Leu Glu Leu Leu Pro Ile Leu Pro Leu 145 150 155 160 Ile Asn Pro Val
Ile Thr Asp Asn Gly Thr Thr Cys Asn Asp Phe Ala 165 170 175 Ser Ser
Gly Asp Pro Asn Tyr Asn Leu Ile Tyr Ser Met Cys Leu Thr 180 185 190
Leu Leu Gly Phe Leu Ile Pro Leu Phe Val Met Cys Phe Phe Tyr Tyr 195
200 205 Lys Ile Ala Leu Phe Leu Lys Gln Arg Asn Arg Gln Val Ala Thr
Ala 210 215 220 Leu Pro Leu Glu Lys Pro Leu Asn Leu Val Ile Met Ala
Val Val Ile 225 230 235 240 Phe Ser Val Leu Phe Thr Pro Tyr His Val
Met Arg Asn Val Arg Ile 245 250 255 Ala Ser Arg Leu Gly Ser Trp Lys
Gln Tyr Gln Cys Thr Gln Val Val 260 265 270 Ile Asn Ser Phe Tyr Ile
Val Thr Arg Pro Leu Ala Phe Leu Asn Ser 275 280 285 Val Ile Asn Pro
Val Phe Tyr Phe Leu Leu Gly Asp His Phe Arg Asp 290 295 300 Met Leu
Met Asn Gln Leu Arg His Asn Phe Lys Ser Leu Thr Ser Phe 305 310 315
320 Ser Arg Trp Ala His Glu Leu Leu Leu Ser Phe Arg Glu Lys 325 330
39 1296 DNA Homo sapiens 39 atgcaggcgc ttaacattac cccggagcag
ttctctcggc tgctgcggga ccacaacctg 60 acgcgggagc agttcatcgc
tctgtaccgg ctgcgaccgc tcgtctacac cccagagctg 120 ccgggacgcg
ccaagctggc cctcgtgctc accggcgtgc tcatcttcgc cctggcgctc 180
tttggcaatg ctctggtgtt ctacgtggtg acccgcagca aggccatgcg caccgtcacc
240 aacatcttta tctgctcctt ggcgctcagt gacctgctca tcaccttctt
ctgcattccc 300 gtcaccatgc tccagaacat ttccgacaac tggctggggg
gtgctttcat ttgcaagatg 360 gtgccatttg tccagtctac cgctgttgtg
acagaaatgc tcactatgac ctgcattgct 420 gtggaaaggc accagggact
tgtgcatcct tttaaaatga agtggcaata caccaaccga 480 agggctttca
caatgctagg tgtggtctgg ctggtggcag tcatcgtagg atcacccatg 540
tggcacgtgc aacaacttga gatcaaatat gacttcctat atgaaaagga acacatctgc
600 tgcttagaag agtggaccag ccctgtgcac cagaagatct acaccacctt
catccttgtc 660 atcctcttcc tcctgcctct tatggtgatg cttattctgt
acagtaaaat tggttatgaa 720 ctttggataa agaaaagagt tggggatggt
tcagtgcttc gaactattca tggaaaagaa 780 atgtccaaaa tagccaggaa
gaagaaacga gctgtcatta tgatggtgac agtggtggct 840 ctctttgctg
tgtgctgggc accattccat gttgtccata tgatgattga atacagtaat 900
tttgaaaagg aatatgatga tgtcacaatc aagatgattt ttgctatcgt gcaaattatt
960 ggattttcca actccatctg taatcccatt gtctatgcat ttatgaatga
aaacttcaaa 1020 aaaaatgttt tgtctgcagt ttgttattgc atagtaaata
aaaccttctc tccagcacaa 1080 aggcatggaa attcaggaat tacaatgatg
cggaagaaag caaagttttc cctcagagag 1140 aatccagtgg aggaaaccaa
aggagaagca ttcagtgatg gcaacattga agtcaaattg 1200 tgtgaacaga
cagaggagaa gaaaaagctc aaacgacatc ttgctctctt taggtctgaa 1260
ctggctgaga attctccttt agacagtggg cattaa 1296 40 431 PRT Homo
sapiens 40 Met Gln Ala Leu Asn Ile Thr Pro Glu Gln Phe Ser Arg Leu
Leu Arg 1 5 10 15 Asp His Asn Leu Thr Arg Glu Gln Phe Ile Ala Leu
Tyr Arg Leu Arg 20 25 30 Pro Leu Val Tyr Thr Pro Glu Leu Pro Gly
Arg Ala Lys Leu Ala Leu 35 40 45 Val Leu Thr Gly Val Leu Ile Phe
Ala Leu Ala Leu Phe Gly Asn Ala 50 55 60 Leu Val Phe Tyr Val Val
Thr Arg Ser Lys Ala Met Arg Thr Val Thr 65 70 75 80 Asn Ile Phe Ile
Cys Ser Leu Ala Leu Ser Asp Leu Leu Ile Thr Phe 85 90 95 Phe Cys
Ile Pro Val Thr Met Leu Gln Asn Ile Ser Asp Asn Trp Leu 100 105 110
Gly Gly Ala Phe Ile Cys Lys Met Val Pro Phe Val Gln Ser Thr Ala 115
120 125 Val Val Thr Glu Met Leu Thr Met Thr Cys Ile Ala Val Glu Arg
His 130 135 140 Gln Gly Leu Val His Pro Phe Lys Met Lys Trp Gln Tyr
Thr Asn Arg 145 150 155 160 Arg Ala Phe Thr Met Leu Gly Val Val Trp
Leu Val Ala Val Ile Val 165 170 175 Gly Ser Pro Met Trp His Val Gln
Gln Leu Glu Ile Lys Tyr Asp Phe 180 185 190 Leu Tyr Glu Lys Glu His
Ile Cys Cys Leu Glu Glu Trp Thr Ser Pro 195 200 205 Val His Gln Lys
Ile Tyr Thr Thr Phe Ile Leu Val Ile Leu Phe Leu 210 215 220 Leu Pro
Leu Met Val Met Leu Ile Leu Tyr Ser Lys Ile Gly Tyr Glu 225 230 235
240 Leu Trp Ile Lys Lys Arg Val Gly Asp Gly Ser Val Leu Arg Thr Ile
245 250 255 His Gly Lys Glu Met Ser Lys Ile Ala Arg Lys Lys Lys Arg
Ala Val 260 265 270 Ile Met Met Val Thr Val Val Ala Leu Phe Ala Val
Cys Trp Ala Pro 275 280 285 Phe His Val Val His Met Met Ile Glu Tyr
Ser Asn Phe Glu Lys Glu 290 295 300 Tyr Asp Asp Val Thr Ile Lys Met
Ile Phe Ala Ile Val Gln Ile Ile 305 310 315 320 Gly Phe Ser Asn Ser
Ile Cys Asn Pro Ile Val Tyr Ala Phe Met Asn 325 330 335 Glu Asn Phe
Lys Lys Asn Val Leu Ser Ala Val Cys Tyr Cys Ile Val 340 345 350 Asn
Lys Thr Phe Ser Pro Ala Gln Arg His Gly Asn Ser Gly Ile Thr 355 360
365 Met Met Arg Lys Lys Ala Lys Phe Ser Leu Arg Glu Asn Pro Val Glu
370 375 380 Glu Thr Lys Gly Glu Ala Phe Ser Asp Gly Asn Ile Glu Val
Lys Leu 385 390 395 400 Cys Glu Gln Thr Glu Glu Lys Lys Lys Leu Lys
Arg His Leu Ala Leu 405 410 415 Phe Arg Ser Glu Leu Ala Glu Asn Ser
Pro Leu Asp Ser Gly His 420 425 430 41 24 DNA Artificial Sequence
Novel Sequence 41 ctgtgtacag cagttcgcag agtg 24 42 24 DNA
Artificial Sequence Novel Sequence 42 gagtgccagg cagagcaggt agac 24
43 31 DNA Artificial Sequence Novel Sequence 43 cccgaattcc
tgcttgctcc cagcttggcc c 31 44 32 DNA Artificial Sequence Novel
Sequence 44 tgtggatcct gctgtcaaag gtcccattcc gg 32 45 20 DNA
Artificial Sequence Novel Sequence 45 tcacaatgct aggtgtggtc 20 46
22 DNA Artificial Sequence Novel Sequence 46 tgcatagaca atgggattac
ag 22 47 511 DNA Homo sapiens 47 tcacaatgct aggtgtggtc tggctggtgg
cagtcatcgt aggatcaccc atgtggcacg 60 tgcaacaact tgagatcaaa
tatgacttcc tatatgaaaa ggaacacatc tgctgcttag 120 aagagtggac
cagccctgtg caccagaaga tctacaccac cttcatcctt gtcatcctct 180
tcctcctgcc tcttatggtg atgcttattc tgtacgtaaa attggttatg aactttggat
240 aaagaaaaga gttggggatg gttcagtgct tcgaactatt catggaaaag
aaatgtccaa 300 aatagccagg aagaagaaac gagctgtcat tatgatggtg
acagtggtgg ctctctttgc 360 tgtgtgctgg gcaccattcc atgttgtcca
tatgatgatt gaatacagta attttgaaaa 420 ggaatatgat gatgtcacaa
tcaagatgat ttttgctatc gtgcaaatta ttggattttc 480 caactccatc
tgtaatccca ttgtctatgc a 511 48 21 DNA Artificial Sequence Novel
Sequence 48 ctgcttagaa gagtggacca g 21 49 22 DNA Artificial
Sequence Novel Sequence 49 ctgtgcacca gaagatctac ac 22 50 21 DNA
Artificial Sequence Novel Sequence 50 caaggatgaa ggtggtgtag a 21 51
23 DNA Artificial Sequence Novel Sequence 51 gtgtagatct tctggtgcac
agg 23 52 21 DNA Artificial Sequence Novel Sequence 52 gcaatgcagg
tcatagtgag c 21 53 27 DNA Artificial Sequence Novel Sequence 53
tggagcatgg tgacgggaat gcagaag 27 54 27 DNA Artificial Sequence
Novel Sequence 54 gtgatgagca ggtcactgag cgccaag 27 55 23 DNA
Artificial Sequence Novel Sequence 55 gcaatgcagg cgcttaacat tac 23
56 22 DNA Artificial Sequence Novel Sequence 56 ttgggttaca
atctgaaggg ca 22 57 23 DNA Artificial Sequence Novel Sequence 57
actccgtgtc cagcaggact ctg 23 58 24 DNA Artificial Sequence Novel
Sequence 58 tgcgtgttcc tggaccctca cgtg 24 59 29 DNA Artificial
Sequence Novel Sequence 59 caggccttgg attttaatgt cagggatgg 29 60 27
DNA Artificial Sequence Novel Sequence 60 ggagagtcag ctctgaaaga
attcagg 27 61 27 DNA Artificial Sequence Novel Sequence 61
tgatgtgatg ccagatacta atagcac 27 62 27 DNA Artificial Sequence
Novel Sequence 62 cctgattcat ttaggtgaga ttgagac 27 63 26 DNA
Artificial Sequence Novel Sequence 63 cccaagcttc cccaggtgta tttgat
26 64 26 DNA Artificial Sequence Novel Sequence 64 gttggatcca
cataatgcat tttctc 26 65 1080 DNA Homo sapiens 65 atgattctca
actcttctac tgaagatggt attaaaagaa tccaagatga ttgtcccaaa 60
gctggaaggc ataattacat atttgtcatg attcctactt tatacagtat catctttgtg
120 gtgggaatat ttggaaacag cttggtggtg atagtcattt acttttatat
gaagctgaag 180 actgtggcca gtgtttttct tttgaattta gcactggctg
acttatgctt tttactgact 240 ttgccactat gggctgtcta cacagctatg
gaataccgct ggccctttgg caattaccta 300 tgtaagattg cttcagccag
cgtcagtttc aacctgtacg ctagtgtgtt tctactcacg 360 tgtctcagca
ttgatcgata cctggctatt gttcacccaa tgaagtcccg ccttcgacgc 420
acaatgcttg tagccaaagt cacctgcatc atcatttggc tgctggcagg cttggccagt
480 ttgccagcta taatccatcg aaatgtattt ttcattgaga acaccaatat
tacagtttgt 540 gctttccatt atgagtccca aaattcaacc cttccgatag
ggctgggcct gaccaaaaat 600 atactgggtt tcctgtttcc ttttctgatc
attcttacaa gttatactct tatttggaag 660 gccctaaaga aggcttatga
aattcagaag aacaaaccaa gaaatgatga tatttttaag 720 ataattatgg
caattgtgct tttctttttc ttttcctgga ttccccacca aatattcact 780
tttctggatg tattgattca actaggcatc atacgtgact gtagaattgc agatattgtg
840 gacacggcca tgcctatcac catttgtata gcttatttta acaattgcct
gaatcctctt 900 ttttatggct ttctggggaa aaaatttaaa agatattttc
tccagcttct aaaatatatt 960 cccccaaaag ccaaatccca ctcaaacctt
tcaacaaaaa tgagcacgct ttcctaccgc 1020 ccctcagata atgtaagctc
atccaccaag aagcctgcac catgttttga ggttgagtga 1080 66 359 PRT Homo
sapiens 66 Met Ile Leu Asn Ser Ser Thr Glu Asp Gly Ile Lys Arg Ile
Gln Asp 1 5 10 15 Asp Cys Pro Lys Ala Gly Arg His Asn Tyr Ile Phe
Val Met Ile Pro 20 25 30 Thr Leu Tyr Ser Ile Ile Phe Val Val Gly
Ile Phe Gly Asn Ser Leu 35 40 45 Val Val Ile Val Ile Tyr Phe Tyr
Met Lys Leu Lys Thr Val Ala Ser 50 55 60 Val Phe Leu Leu Asn Leu
Ala Leu Ala Asp Leu Cys Phe Leu Leu Thr 65 70 75 80 Leu Pro Leu Trp
Ala Val Tyr Thr Ala Met Glu Tyr Arg Trp Pro Phe 85 90 95 Gly Asn
Tyr Leu Cys Lys Ile Ala Ser Ala Ser Val Ser Phe Asn Leu 100 105 110
Tyr Ala Ser Val Phe Leu Leu Thr Cys Leu Ser Ile Asp Arg Tyr Leu 115
120 125 Ala Ile Val His Pro Met Lys Ser Arg Leu Arg Arg Thr Met Leu
Val 130 135 140 Ala Lys Val Thr Cys Ile Ile Ile Trp Leu Leu Ala Gly
Leu Ala Ser 145 150 155 160 Leu Pro Ala Ile Ile His Arg Asn Val Phe
Phe Ile Glu Asn Thr Asn 165 170 175 Ile Thr Val Cys Ala Phe His Tyr
Glu Ser Gln Asn Ser Thr Leu Pro 180 185 190 Ile Gly Leu Gly Leu Thr
Lys Asn Ile Leu Gly Phe Leu Phe Pro Phe 195 200 205 Leu Ile Ile Leu
Thr Ser Tyr Thr Leu Ile Trp Lys Ala Leu Lys Lys 210 215 220 Ala Tyr
Glu Ile Gln Lys Asn Lys Pro Arg Asn Asp Asp Ile Phe Lys 225 230 235
240 Ile Ile Met Ala Ile Val Leu Phe Phe Phe Phe Ser Trp Ile Pro His
245 250 255 Gln Ile Phe Thr Phe Leu Asp Val Leu Ile Gln Leu Gly Ile
Ile Arg 260 265 270 Asp Cys Arg Ile Ala Asp Ile Val Asp Thr Ala Met
Pro Ile Thr Ile 275 280 285 Cys Ile Ala Tyr Phe Asn Asn Cys Leu Asn
Pro Leu Phe Tyr Gly Phe 290 295 300 Leu Gly Lys Lys Phe Lys Arg Tyr
Phe Leu Gln Leu Leu Lys Tyr Ile 305 310 315 320 Pro Pro Lys Ala Lys
Ser His Ser Asn Leu Ser Thr Lys Met Ser Thr 325 330 335 Leu Ser Tyr
Arg Pro Ser Asp Asn Val Ser Ser Ser Thr Lys Lys Pro 340 345 350 Ala
Pro Cys Phe Glu Val Glu 355 67 27 DNA Artificial Sequence Novel
Sequence 67 accatgggca gcccctggaa cggcagc 27 68 39 DNA Artificial
Sequence Novel Sequence 68 agaaccacca ccagcaggac gcggacggtc
tgccggtgg 39 69 39 DNA Artificial Sequence Novel Sequence 69
gtccgcgtcc tgctggtggt ggttctggca tttataatt 39 70 33 DNA Artificial
Sequence Novel Sequence 70 cctggatcct tatcccatcg tcttcacgtt agc 33
71 26 DNA Artificial Sequence Novel Sequence 71 ctggaattct
cctgccagca tggtga 26 72 30 DNA Artificial Sequence Novel Sequence
72 gcaggatcct atattgcgtg ctctgtcccc 30 73 999 DNA Homo sapiens 73
atggtgaact ccacccaccg tgggatgcac acttctctgc acctctggaa ccgcagcagt
60 tacagactgc acagcaatgc cagtgagtcc cttggaaaag gctactctga
tggagggtgc 120 tacgagcaac tttttgtctc tcctgaggtg tttgtgactc
tgggtgtcat cagcttgttg 180 gagaatatct tagtgattgt ggcaatagcc
aagaacaaga atctgcattc acccatgtac 240 tttttcatct gcagcttggc
tgtggctgat atgctggtga gcgtttcaaa tggatcagaa 300 accattatca
tcaccctatt aaacagtaca gatacggatg cacagagttt cacagtgaat 360
attgataatg tcattgactc ggtgatctgt agctccttgc ttgcatccat ttgcagcctg
420 ctttcaattg cagtggacag gtactttact atcttctatg ctctccagta
ccataacatt 480 atgacagtta
agcgggttgg gatcagcata agttgtatct gggcagcttg cacggtttca 540
ggcattttgt tcatcattta ctcagatagt agtgctgtca tcatctgcct catcaccatg
600 ttcttcacca tgctggctct catggcttct ctctatgtcc acatgttcct
gatggccagg 660 cttcacatta agaggattgc tgtcctcccc ggcactggtg
ccatccgcca aggtgccaat 720 atgaagggag cgattacctt gaccatcctg
attggcgtct ttgttgtctg ctgggcccca 780 ttcttcctcc acttaatatt
ctacatctct tgtcctcaga atccatattg tgtgtgcttc 840 atgtctcact
ttaacttgta tctcatactg atcatgtgta attcaatcat cgatcctctg 900
atttatgcac tccggagtca agaactgagg aaaaccttca aagagatcat ctgttgctat
960 cccctgggag gcctttgtga cttgtctagc agatattaa 999 74 332 PRT Homo
sapiens 74 Met Val Asn Ser Thr His Arg Gly Met His Thr Ser Leu His
Leu Trp 1 5 10 15 Asn Arg Ser Ser Tyr Arg Leu His Ser Asn Ala Ser
Glu Ser Leu Gly 20 25 30 Lys Gly Tyr Ser Asp Gly Gly Cys Tyr Glu
Gln Leu Phe Val Ser Pro 35 40 45 Glu Val Phe Val Thr Leu Gly Val
Ile Ser Leu Leu Glu Asn Ile Leu 50 55 60 Val Ile Val Ala Ile Ala
Lys Asn Lys Asn Leu His Ser Pro Met Tyr 65 70 75 80 Phe Phe Ile Cys
Ser Leu Ala Val Ala Asp Met Leu Val Ser Val Ser 85 90 95 Asn Gly
Ser Glu Thr Ile Ile Ile Thr Leu Leu Asn Ser Thr Asp Thr 100 105 110
Asp Ala Gln Ser Phe Thr Val Asn Ile Asp Asn Val Ile Asp Ser Val 115
120 125 Ile Cys Ser Ser Leu Leu Ala Ser Ile Cys Ser Leu Leu Ser Ile
Ala 130 135 140 Val Asp Arg Tyr Phe Thr Ile Phe Tyr Ala Leu Gln Tyr
His Asn Ile 145 150 155 160 Met Thr Val Lys Arg Val Gly Ile Ser Ile
Ser Cys Ile Trp Ala Ala 165 170 175 Cys Thr Val Ser Gly Ile Leu Phe
Ile Ile Tyr Ser Asp Ser Ser Ala 180 185 190 Val Ile Ile Cys Leu Ile
Thr Met Phe Phe Thr Met Leu Ala Leu Met 195 200 205 Ala Ser Leu Tyr
Val His Met Phe Leu Met Ala Arg Leu His Ile Lys 210 215 220 Arg Ile
Ala Val Leu Pro Gly Thr Gly Ala Ile Arg Gln Gly Ala Asn 225 230 235
240 Met Lys Gly Ala Ile Thr Leu Thr Ile Leu Ile Gly Val Phe Val Val
245 250 255 Cys Trp Ala Pro Phe Phe Leu His Leu Ile Phe Tyr Ile Ser
Cys Pro 260 265 270 Gln Asn Pro Tyr Cys Val Cys Phe Met Ser His Phe
Asn Leu Tyr Leu 275 280 285 Ile Leu Ile Met Cys Asn Ser Ile Ile Asp
Pro Leu Ile Tyr Ala Leu 290 295 300 Arg Ser Gln Glu Leu Arg Lys Thr
Phe Lys Glu Ile Ile Cys Cys Tyr 305 310 315 320 Pro Leu Gly Gly Leu
Cys Asp Leu Ser Ser Arg Tyr 325 330 75 32 DNA Artificial Sequence
Novel Sequence 75 ccgaagcttc gagctgagta aggcggcggg ct 32 76 31 DNA
Artificial Sequence Novel Sequence 76 gtggaattca tttgccctgc
ctcaaccccc a 31 77 1344 DNA Homo sapiens 77 atggagctgc taaagctgaa
ccggagcgtg cagggaaccg gacccgggcc gggggcttcc 60 ctgtgccgcc
cgggggcgcc tctcctcaac agcagcagtg tgggcaacct cagctgcgag 120
ccccctcgca ttcgcggagc cgggacacga gaattggagc tggccattag aatcactctt
180 tacgcagtga tcttcctgat gagcgttgga ggaaatatgc tcatcatcgt
ggtcctggga 240 ctgagccgcc gcctgaggac tgtcaccaat gccttcctcc
tctcactggc agtcagcgac 300 ctcctgctgg ctgtggcttg catgcccttc
accctcctgc ccaatctcat gggcacattc 360 atctttggca ccgtcatctg
caaggcggtt tcctacctca tgggggtgtc tgtgagtgtg 420 tccacgctaa
gcctcgtggc catcgcactg gagcgatata gcgccatctg ccgaccactg 480
caggcacgag tgtggcagac gcgctcccac gcggctcgcg tgattgtagc cacgtggctg
540 ctgtccggac tactcatggt gccctacccc gtgtacactg tcgtgcaacc
agtggggcct 600 cgtgtgctgc agtgcgtgca tcgctggccc agtgcgcggg
tccgccagac ctggtccgta 660 ctgctgcttc tgctcttgtt cttcatccca
ggtgtggtta tggccgtggc ctacgggctt 720 atctctcgcg agctctactt
agggcttcgc tttgacggcg acagtgacag cgacagccaa 780 agcagggtcc
gaaaccaagg cgggctgcca ggggctgttc accagaacgg gcgttgccgg 840
cctgagactg gcgcggttgg caaagacagc gatggctgct acgtgcaact tccacgttcc
900 cggcctgccc tggagctgac ggcgctgacg gctcctgggc cgggatccgg
ctcccggccc 960 acccaggcca agctgctggc taagaagcgc gtggtgcgaa
tgttgctggt gatcgttgtg 1020 cttttttttc tgtgttggtt gccagtttat
agtgccaaca cgtggcgcgc ctttgatggc 1080 ccgggtgcac accgagcact
ctcgggtgct cctatctcct tcattcactt gctgagctac 1140 gcctcggcct
gtgtcaaccc cctggtctac tgcttcatgc accgtcgctt tcgccaggcc 1200
tgcctggaaa cttgcgctcg ctgctgcccc cggcctccac gagctcgccc cagggctctt
1260 cccgatgagg accctcccac tccctccatt gcttcgctgt ccaggcttag
ctacaccacc 1320 atcagcacac tgggccctgg ctga 1344 78 447 PRT Homo
sapiens 78 Met Glu Leu Leu Lys Leu Asn Arg Ser Val Gln Gly Thr Gly
Pro Gly 1 5 10 15 Pro Gly Ala Ser Leu Cys Arg Pro Gly Ala Pro Leu
Leu Asn Ser Ser 20 25 30 Ser Val Gly Asn Leu Ser Cys Glu Pro Pro
Arg Ile Arg Gly Ala Gly 35 40 45 Thr Arg Glu Leu Glu Leu Ala Ile
Arg Ile Thr Leu Tyr Ala Val Ile 50 55 60 Phe Leu Met Ser Val Gly
Gly Asn Met Leu Ile Ile Val Val Leu Gly 65 70 75 80 Leu Ser Arg Arg
Leu Arg Thr Val Thr Asn Ala Phe Leu Leu Ser Leu 85 90 95 Ala Val
Ser Asp Leu Leu Leu Ala Val Ala Cys Met Pro Phe Thr Leu 100 105 110
Leu Pro Asn Leu Met Gly Thr Phe Ile Phe Gly Thr Val Ile Cys Lys 115
120 125 Ala Val Ser Tyr Leu Met Gly Val Ser Val Ser Val Ser Thr Leu
Ser 130 135 140 Leu Val Ala Ile Ala Leu Glu Arg Tyr Ser Ala Ile Cys
Arg Pro Leu 145 150 155 160 Gln Ala Arg Val Trp Gln Thr Arg Ser His
Ala Ala Arg Val Ile Val 165 170 175 Ala Thr Trp Leu Leu Ser Gly Leu
Leu Met Val Pro Tyr Pro Val Tyr 180 185 190 Thr Val Val Gln Pro Val
Gly Pro Arg Val Leu Gln Cys Val His Arg 195 200 205 Trp Pro Ser Ala
Arg Val Arg Gln Thr Trp Ser Val Leu Leu Leu Leu 210 215 220 Leu Leu
Phe Phe Ile Pro Gly Val Val Met Ala Val Ala Tyr Gly Leu 225 230 235
240 Ile Ser Arg Glu Leu Tyr Leu Gly Leu Arg Phe Asp Gly Asp Ser Asp
245 250 255 Ser Asp Ser Gln Ser Arg Val Arg Asn Gln Gly Gly Leu Pro
Gly Ala 260 265 270 Val His Gln Asn Gly Arg Cys Arg Pro Glu Thr Gly
Ala Val Gly Lys 275 280 285 Asp Ser Asp Gly Cys Tyr Val Gln Leu Pro
Arg Ser Arg Pro Ala Leu 290 295 300 Glu Leu Thr Ala Leu Thr Ala Pro
Gly Pro Gly Ser Gly Ser Arg Pro 305 310 315 320 Thr Gln Ala Lys Leu
Leu Ala Lys Lys Arg Val Val Arg Met Leu Leu 325 330 335 Val Ile Val
Val Leu Phe Phe Leu Cys Trp Leu Pro Val Tyr Ser Ala 340 345 350 Asn
Thr Trp Arg Ala Phe Asp Gly Pro Gly Ala His Arg Ala Leu Ser 355 360
365 Val Ala Pro Ile Ser Phe Ile His Leu Leu Ser Tyr Ala Ser Ala Cys
370 375 380 Val Asn Pro Leu Val Tyr Cys Phe Met His Arg Arg Phe Arg
Gln Ala 385 390 395 400 Cys Leu Glu Thr Cys Ala Arg Cys Cys Pro Arg
Pro Pro Arg Ala Arg 405 410 415 Pro Arg Ala Leu Pro Asp Glu Asp Pro
Pro Thr Pro Ser Ile Ala Ser 420 425 430 Leu Ser Arg Leu Ser Tyr Thr
Thr Ile Ser Thr Leu Gly Pro Gly 435 440 445 79 30 DNA Artificial
Sequence Novel Sequence 79 tgcaagctta aaaaggaaaa aatgaacagc 30 80
30 DNA Artificial Sequence Novel Sequence 80 taaggatccc ttcccttcaa
aacatccttg 30 81 1014 DNA Homo sapiens 81 atgaacagca catgtattga
agaacagcat gacctggatc actatttgtt tcccattgtt 60 tacatctttg
tgattatagt cagcattcca gccaatattg gatctctgtg tgtgtctttc 120
ctgcaaccca agaaggaaag tgaactagga atttacctct tcagtttgtc actatcagat
180 ttactctatg cattaactct ccctttatgg attgattata cttggaataa
agacaactgg 240 actttctctc ctgccttgtg caaagggagt gcttttctca
tgtacatgaa gttttacagc 300 agcacagcat tcctcacctg cattgccgtt
gatcggtatt tggctgttgt ctaccctttg 360 aagttttttt tcctaaggac
aagaagaatt gcactcatgg tcagcctgtc catctggata 420 ttggaaacca
tcttcaatgc tgtcatgttg tgggaagatg aaacagttgt tgaatattgc 480
gatgccgaaa agtctaattt tactttatgc tatgacaaat accctttaga gaaatggcaa
540 atcaacctca acttgttcag gacgtgtaca ggctatgcaa tacctttggt
caccatcctg 600 atctgtaacc ggaaagtcta ccaagctgtg cggcacaata
aagccacgga aaacaaggaa 660 aagaagagaa tcataaaact acttgtcagc
atcacagtta cttttgtctt atgctttact 720 ccctttcatg tgatgttgct
gattcgctgc attttagagc atgctgtgaa cttcgaagac 780 cacagcaatt
ctgggaagcg aacttacaca atgtatagaa tcacggttgc attaacaagt 840
ttaaattgtg ttgctgatcc aattctgtac tgttttgtta ccgaaacagg aagatatgat
900 atgtggaata tattaaaatt ctgcactggg aggtgtaata catcacaaag
acaaagaaaa 960 cgcatacttt ctgtgtctac aaaagatact atggaattag
aggtccttga gtag 1014 82 337 PRT Homo sapiens 82 Met Asn Ser Thr Cys
Ile Glu Glu Gln His Asp Leu Asp His Tyr Leu 1 5 10 15 Phe Pro Ile
Val Tyr Ile Phe Val Ile Ile Val Ser Ile Pro Ala Asn 20 25 30 Ile
Gly Ser Leu Cys Val Ser Phe Leu Gln Pro Lys Lys Glu Ser Glu 35 40
45 Leu Gly Ile Tyr Leu Phe Ser Leu Ser Leu Ser Asp Leu Leu Tyr Ala
50 55 60 Leu Thr Leu Pro Leu Trp Ile Asp Tyr Thr Trp Asn Lys Asp
Asn Trp 65 70 75 80 Thr Phe Ser Pro Ala Leu Cys Lys Gly Ser Ala Phe
Leu Met Tyr Met 85 90 95 Lys Phe Tyr Ser Ser Thr Ala Phe Leu Thr
Cys Ile Ala Val Asp Arg 100 105 110 Tyr Leu Ala Val Val Tyr Pro Leu
Lys Phe Phe Phe Leu Arg Thr Arg 115 120 125 Arg Ile Ala Leu Met Val
Ser Leu Ser Ile Trp Ile Leu Glu Thr Ile 130 135 140 Phe Asn Ala Val
Met Leu Trp Glu Asp Glu Thr Val Val Glu Tyr Cys 145 150 155 160 Asp
Ala Glu Lys Ser Asn Phe Thr Leu Cys Tyr Asp Lys Tyr Pro Leu 165 170
175 Glu Lys Trp Gln Ile Asn Leu Asn Leu Phe Arg Thr Cys Thr Gly Tyr
180 185 190 Ala Ile Pro Leu Val Thr Ile Leu Ile Cys Asn Arg Lys Val
Tyr Gln 195 200 205 Ala Val Arg His Asn Lys Ala Thr Glu Asn Lys Glu
Lys Lys Arg Ile 210 215 220 Ile Lys Leu Leu Val Ser Ile Thr Val Thr
Phe Val Leu Cys Phe Thr 225 230 235 240 Pro Phe His Val Met Leu Leu
Ile Arg Cys Ile Leu Glu His Ala Val 245 250 255 Asn Phe Glu Asp His
Ser Asn Ser Gly Lys Arg Thr Tyr Thr Met Tyr 260 265 270 Arg Ile Thr
Val Ala Leu Thr Ser Leu Asn Cys Val Ala Asp Pro Ile 275 280 285 Leu
Tyr Cys Phe Val Thr Glu Thr Gly Arg Tyr Asp Met Trp Asn Ile 290 295
300 Leu Lys Phe Cys Thr Gly Arg Cys Asn Thr Ser Gln Arg Gln Arg Lys
305 310 315 320 Arg Ile Leu Ser Val Ser Thr Lys Asp Thr Met Glu Leu
Glu Val Leu 325 330 335 Glu 83 40 DNA Artificial Sequence Novel
Sequence 83 caggaagaag aaacgagctg tcattatgat ggtgacagtg 40 84 40
DNA Artificial Sequence Novel Sequence 84 cactgtcacc atcataatga
cagctcgttt cttcttcctg 40 85 30 DNA Artificial Sequence Novel
Sequence 85 ggccaccggc agaccaaacg cgtcctgctg 30 86 31 DNA
Artificial Sequence Novel Sequence 86 ctccttcggt cctcctatcg
ttgtcagaag t 31 87 37 DNA Artificial Sequence Novel Sequence 87
ggaaaagaag agaatcaaaa aactacttgt cagcatc 37 88 31 DNA Artificial
Sequence Novel Sequence 88 ctccttcggt cctcctatcg ttgtcagaag t 31 89
1080 DNA Homo sapiens 89 atgattctca actcttctac tgaagatggt
attaaaagaa tccaagatga ttgtcccaaa 60 gctggaaggc ataattacat
atttgtcatg attcctactt tatacagtat catctttgtg 120 gtgggaatat
ttggaaacag cttggtggtg atagtcattt acttttatat gaagctgaag 180
actgtggcca gtgtttttct tttgaattta gcactggctg acttatgctt tttactgact
240 ttgccactat gggctgtcta cacagctatg gaataccgct ggccctttgg
caattaccta 300 tgtaagattg cttcagccag cgtcagtttc aacctgtacg
ctagtgtgtt tctactcacg 360 tgtctcagca ttgatcgata cctggctatt
gttcacccaa tgaagtcccg ccttcgacgc 420 acaatgcttg tagccaaagt
cacctgcatc atcatttggc tgctggcagg cttggccagt 480 ttgccagcta
taatccatcg aaatgtattt ttcattgaga acaccaatat tacagtttgt 540
gctttccatt atgagtccca aaattcaacc cttccgatag ggctgggcct gaccaaaaat
600 atactgggtt tcctgtttcc ttttctgatc attcttacaa gttatactct
tatttggaag 660 gccctaaaga aggcttatga aattcagaag aacaaaccaa
gaaatgatga tattaaaaag 720 ataattatgg caattgtgct tttctttttc
ttttcctgga ttccccacca aatattcact 780 tttctggatg tattgattca
actaggcatc atacgtgact gtagaattgc agatattgtg 840 gacacggcca
tgcctatcac catttgtata gcttatttta acaattgcct gaatcctctt 900
ttttatggct ttctggggaa aaaatttaaa agatattttc tccagcttct aaaatatatt
960 cccccaaaag ccaaatccca ctcaaacctt tcaacaaaaa tgagcacgct
ttcctaccgc 1020 ccctcagata atgtaagctc atccaccaag aagcctgcac
catgttttga ggttgagtga 1080 90 359 PRT Homo sapiens 90 Met Ile Leu
Asn Ser Ser Thr Glu Asp Gly Ile Lys Arg Ile Gln Asp 1 5 10 15 Asp
Cys Pro Lys Ala Gly Arg His Asn Tyr Ile Phe Val Met Ile Pro 20 25
30 Thr Leu Tyr Ser Ile Ile Phe Val Val Gly Ile Phe Gly Asn Ser Leu
35 40 45 Val Val Ile Val Ile Tyr Phe Tyr Met Lys Leu Lys Thr Val
Ala Ser 50 55 60 Val Phe Leu Leu Asn Leu Ala Leu Ala Asp Leu Cys
Phe Leu Leu Thr 65 70 75 80 Leu Pro Leu Trp Ala Val Tyr Thr Ala Met
Glu Tyr Arg Trp Pro Phe 85 90 95 Gly Asn Tyr Leu Cys Lys Ile Ala
Ser Ala Ser Val Ser Phe Asn Leu 100 105 110 Tyr Ala Ser Val Phe Leu
Leu Thr Cys Leu Ser Ile Asp Arg Tyr Leu 115 120 125 Ala Ile Val His
Pro Met Lys Ser Arg Leu Arg Arg Thr Met Leu Val 130 135 140 Ala Lys
Val Thr Cys Ile Ile Ile Trp Leu Leu Ala Gly Leu Ala Ser 145 150 155
160 Leu Pro Ala Ile Ile His Arg Asn Val Phe Phe Ile Glu Asn Thr Asn
165 170 175 Ile Thr Val Cys Ala Phe His Tyr Glu Ser Gln Asn Ser Thr
Leu Pro 180 185 190 Ile Gly Leu Gly Leu Thr Lys Asn Ile Leu Gly Phe
Leu Phe Pro Phe 195 200 205 Leu Ile Ile Leu Thr Ser Tyr Thr Leu Ile
Trp Lys Ala Leu Lys Lys 210 215 220 Ala Tyr Glu Ile Gln Lys Asn Lys
Pro Arg Asn Asp Asp Ile Lys Lys 225 230 235 240 Ile Ile Met Ala Ile
Val Leu Phe Phe Phe Phe Ser Trp Ile Pro His 245 250 255 Gln Ile Phe
Thr Phe Leu Asp Val Leu Ile Gln Leu Gly Ile Ile Arg 260 265 270 Asp
Cys Arg Ile Ala Asp Ile Val Asp Thr Ala Met Pro Ile Thr Ile 275 280
285 Cys Ile Ala Tyr Phe Asn Asn Cys Leu Asn Pro Leu Phe Tyr Gly Phe
290 295 300 Leu Gly Lys Lys Phe Lys Arg Tyr Phe Leu Gln Leu Leu Lys
Tyr Ile 305 310 315 320 Pro Pro Lys Ala Lys Ser His Ser Asn Leu Ser
Thr Lys Met Ser Thr 325 330 335 Leu Ser Tyr Arg Pro Ser Asp Asn Val
Ser Ser Ser Thr Lys Lys Pro 340 345 350 Ala Pro Cys Phe Glu Val Glu
355 91 35 DNA Artificial Sequence Novel Sequence 91 ccaagaaatg
atgatattaa aaagataatt atggc 35 92 31 DNA Artificial Sequence Novel
Sequence 92 ctccttcggt cctcctatcg ttgtcagaag t 31 93 1080 DNA Homo
sapiens 93 atgattctca actcttctac tgaagatggt attaaaagaa tccaagatga
ttgtcccaaa 60 gctggaaggc ataattacat atttgtcatg attcctactt
tatacagtat catctttgtg 120 gtgggaatat ttggaaacag cttggtggtg
atagtcattt acttttatat gaagctgaag 180 actgtggcca gtgtttttct
tttgaattta gcactggctg acttatgctt tttactgact 240 ttgccactat
gggctgtcta cacagctatg gaataccgct ggccctttgg caattaccta 300
tgtaagattg cttcagccag cgtcagtttc gccctgtacg ctagtgtgtt tctactcacg
360 tgtctcagca ttgatcgata cctggctatt gttcacccaa tgaagtcccg
ccttcgacgc 420 acaatgcttg tagccaaagt cacctgcatc atcatttggc
tgctggcagg cttggccagt 480 ttgccagcta taatccatcg aaatgtattt
ttcattgaga acaccaatat tacagtttgt 540 gctttccatt
atgagtccca aaattcaacc cttccgatag ggctgggcct gaccaaaaat 600
atactgggtt tcctgtttcc ttttctgatc attcttacaa gttatactct tatttggaag
660 gccctaaaga aggcttatga aattcagaag aacaaaccaa gaaatgatga
tatttttaag 720 ataattatgg caattgtgct tttctttttc ttttcctgga
ttccccacca aatattcact 780 tttctggatg tattgattca actaggcatc
atacgtgact gtagaattgc agatattgtg 840 gacacggcca tgcctatcac
catttgtata gcttatttta acaattgcct gaatcctctt 900 ttttatggct
ttctggggaa aaaatttaaa agatattttc tccagcttct aaaatatatt 960
cccccaaaag ccaaatccca ctcaaacctt tcaacaaaaa tgagcacgct ttcctaccgc
1020 ccctcagata atgtaagctc atccaccaag aagcctgcac catgttttga
ggttgagtga 1080 94 359 PRT Homo sapiens 94 Met Ile Leu Asn Ser Ser
Thr Glu Asp Gly Ile Lys Arg Ile Gln Asp 1 5 10 15 Asp Cys Pro Lys
Ala Gly Arg His Asn Tyr Ile Phe Val Met Ile Pro 20 25 30 Thr Leu
Tyr Ser Ile Ile Phe Val Val Gly Ile Phe Gly Asn Ser Leu 35 40 45
Val Val Ile Val Ile Tyr Phe Tyr Met Lys Leu Lys Thr Val Ala Ser 50
55 60 Val Phe Leu Leu Asn Leu Ala Leu Ala Asp Leu Cys Phe Leu Leu
Thr 65 70 75 80 Leu Pro Leu Trp Ala Val Tyr Thr Ala Met Glu Tyr Arg
Trp Pro Phe 85 90 95 Gly Asn Tyr Leu Cys Lys Ile Ala Ser Ala Ser
Val Ser Phe Ala Leu 100 105 110 Tyr Ala Ser Val Phe Leu Leu Thr Cys
Leu Ser Ile Asp Arg Tyr Leu 115 120 125 Ala Ile Val His Pro Met Lys
Ser Arg Leu Arg Arg Thr Met Leu Val 130 135 140 Ala Lys Val Thr Cys
Ile Ile Ile Trp Leu Leu Ala Gly Leu Ala Ser 145 150 155 160 Leu Pro
Ala Ile Ile His Arg Asn Val Phe Phe Ile Glu Asn Thr Asn 165 170 175
Ile Thr Val Cys Ala Phe His Tyr Glu Ser Gln Asn Ser Thr Leu Pro 180
185 190 Ile Gly Leu Gly Leu Thr Lys Asn Ile Leu Gly Phe Leu Phe Pro
Phe 195 200 205 Leu Ile Ile Leu Thr Ser Tyr Thr Leu Ile Trp Lys Ala
Leu Lys Lys 210 215 220 Ala Tyr Glu Ile Gln Lys Asn Lys Pro Arg Asn
Asp Asp Ile Phe Lys 225 230 235 240 Ile Ile Met Ala Ile Val Leu Phe
Phe Phe Phe Ser Trp Ile Pro His 245 250 255 Gln Ile Phe Thr Phe Leu
Asp Val Leu Ile Gln Leu Gly Ile Ile Arg 260 265 270 Asp Cys Arg Ile
Ala Asp Ile Val Asp Thr Ala Met Pro Ile Thr Ile 275 280 285 Cys Ile
Ala Tyr Phe Asn Asn Cys Leu Asn Pro Leu Phe Tyr Gly Phe 290 295 300
Leu Gly Lys Lys Phe Lys Arg Tyr Phe Leu Gln Leu Leu Lys Tyr Ile 305
310 315 320 Pro Pro Lys Ala Lys Ser His Ser Asn Leu Ser Thr Lys Met
Ser Thr 325 330 335 Leu Ser Tyr Arg Pro Ser Asp Asn Val Ser Ser Ser
Thr Lys Lys Pro 340 345 350 Ala Pro Cys Phe Glu Val Glu 355 95 26
DNA Artificial Sequence Novel Sequence 95 cccaagcttc cccaggtgta
tttgat 26 96 29 DNA Artificial Sequence Novel Sequence 96
cctgcaggcg aaactgactc tggctgaag 29 97 42 DNA Artificial Sequence
Novel Sequence 97 ctgtacgcta gtgtgtttct actcacgtgt ctcagcattg at 42
98 26 DNA Artificial Sequence Novel Sequence 98 gttggatcca
cataatgcat tttctc 26 99 1080 DNA Homo sapiens 99 atgattctca
actcttctac tgaagatggt attaaaagaa tccaagatga ttgtcccaaa 60
gctggaaggc ataattacat atttgtcatg attcctactt tatacagtat catctttgtg
120 gtgggaatat ttggaaacag cttggtggtg atagtcattt acttttatat
gaagctgaag 180 actgtggcca gtgtttttct tttgaattta gcactggctg
acttatgctt tttactgact 240 ttgccactat gggctgtcta cacagctatg
gaataccgct ggccctttgg caattaccta 300 tgtaagattg cttcagccag
cgtcagtttc aacctgtacg ctagtgtgtt tctactcacg 360 tgtctcagca
ttgatcgata cctggctatt gttcacccaa tgaagtcccg ccttcgacgc 420
acaatgcttg tagccaaagt cacctgcatc atcatttggc tgctggcagg cttggccagt
480 ttgccagcta taatccatcg aaatgtattt ttcattgaga acaccaatat
tacagtttgt 540 gctttccatt atgagtccca aaattcaacc cttccgatag
ggctgggcct gaccaaaaat 600 atactgggtt tcctgtttcc ttttctgatc
attcttacaa gttattttgg aattcgaaaa 660 cacttactga agacgaatag
ctatgggaag aacaggataa cccgtgacca agttaagaag 720 ataattatgg
caattgtgct tttctttttc ttttcctgga ttccccacca aatattcact 780
tttctggatg tattgattca actaggcatc atacgtgact gtagaattgc agatattgtg
840 gacacggcca tgcctatcac catttgtata gcttatttta acaattgcct
gaatcctctt 900 ttttatggct ttctggggaa aaaatttaaa agatattttc
tccagcttct aaaatatatt 960 cccccaaaag ccaaatccca ctcaaacctt
tcaacaaaaa tgagcacgct ttcctaccgc 1020 ccctcagata atgtaagctc
atccaccaag aagcctgcac catgttttga ggttgagtga 1080 100 359 PRT Homo
sapiens 100 Met Ile Leu Asn Ser Ser Thr Glu Asp Gly Ile Lys Arg Ile
Gln Asp 1 5 10 15 Asp Cys Pro Lys Ala Gly Arg His Asn Tyr Ile Phe
Val Met Ile Pro 20 25 30 Thr Leu Tyr Ser Ile Ile Phe Val Val Gly
Ile Phe Gly Asn Ser Leu 35 40 45 Val Val Ile Val Ile Tyr Phe Tyr
Met Lys Leu Lys Thr Val Ala Ser 50 55 60 Val Phe Leu Leu Asn Leu
Ala Leu Ala Asp Leu Cys Phe Leu Leu Thr 65 70 75 80 Leu Pro Leu Trp
Ala Val Tyr Thr Ala Met Glu Tyr Arg Trp Pro Phe 85 90 95 Gly Asn
Tyr Leu Cys Lys Ile Ala Ser Ala Ser Val Ser Phe Asn Leu 100 105 110
Tyr Ala Ser Val Phe Leu Leu Thr Cys Leu Ser Ile Asp Arg Tyr Leu 115
120 125 Ala Ile Val His Pro Met Lys Ser Arg Leu Arg Arg Thr Met Leu
Val 130 135 140 Ala Lys Val Thr Cys Ile Ile Ile Trp Leu Leu Ala Gly
Leu Ala Ser 145 150 155 160 Leu Pro Ala Ile Ile His Arg Asn Val Phe
Phe Ile Glu Asn Thr Asn 165 170 175 Ile Thr Val Cys Ala Phe His Tyr
Glu Ser Gln Asn Ser Thr Leu Pro 180 185 190 Ile Gly Leu Gly Leu Thr
Lys Asn Ile Leu Gly Phe Leu Phe Pro Phe 195 200 205 Leu Ile Ile Leu
Thr Ser Tyr Phe Gly Ile Arg Lys His Leu Leu Lys 210 215 220 Thr Asn
Ser Tyr Gly Lys Asn Arg Ile Thr Arg Asp Gln Val Lys Lys 225 230 235
240 Ile Ile Met Ala Ile Val Leu Phe Phe Phe Phe Ser Trp Ile Pro His
245 250 255 Gln Ile Phe Thr Phe Leu Asp Val Leu Ile Gln Leu Gly Ile
Ile Arg 260 265 270 Asp Cys Arg Ile Ala Asp Ile Val Asp Thr Ala Met
Pro Ile Thr Ile 275 280 285 Cys Ile Ala Tyr Phe Asn Asn Cys Leu Asn
Pro Leu Phe Tyr Gly Phe 290 295 300 Leu Gly Lys Lys Phe Lys Arg Tyr
Phe Leu Gln Leu Leu Lys Tyr Ile 305 310 315 320 Pro Pro Lys Ala Lys
Ser His Ser Asn Leu Ser Thr Lys Met Ser Thr 325 330 335 Leu Ser Tyr
Arg Pro Ser Asp Asn Val Ser Ser Ser Thr Lys Lys Pro 340 345 350 Ala
Pro Cys Phe Glu Val Glu 355 101 37 DNA Artificial Sequence Novel
Sequence 101 tccgaattcc aaaataactt gtaagaatga tcagaaa 37 102 33 DNA
Artificial Sequence Novel Sequence 102 agatcttaag aagataatta
tggcaattgt gct 33 103 62 DNA Artificial Sequence Novel Sequence 103
aattcgaaaa cacttactga agacgaatag ctatgggaag aacaggataa cccgtgacca
60 ag 62 104 62 DNA Artificial Sequence Novel Sequence 104
ttaacttggt cacgggttat cctgttcttc ccatagctat tcgtcttcag taagtgtttt
60 cg 62 105 1083 DNA Homo sapiens 105 atgattctca actcttctac
tgaagatggt attaaaagaa tccaagatga ttgtcccaaa 60 gctggaaggc
ataattacat atttgtcatg attcctactt tatacagtat catctttgtg 120
gtgggaatat ttggaaacag cttggtggtg atagtcattt acttttatat gaagctgaag
180 actgtggcca gtgtttttct tttgaattta gcactggctg acttatgctt
tttactgact 240 ttgccactat gggctgtcta cacagctatg gaataccgct
ggccctttgg caattaccta 300 tgtaagattg cttcagccag cgtcagtttc
aacctgtacg ctagtgtgtt tctactcacg 360 tgtctcagca ttgatcgata
cctggctatt gttcacccaa tgaagtcccg ccttcgacgc 420 acaatgcttg
tagccaaagt cacctgcatc atcatttggc tgctggcagg cttggccagt 480
ttgccagcta taatccatcg aaatgtattt ttcattgaga acaccaatat tacagtttgt
540 gctttccatt atgagtccca aaattcaacc cttccgatag ggctgggcct
gaccaaaaat 600 atactgggtt tcctgtttcc ttttctgatc attcttacaa
gttatactct tatttggaag 660 gccctaaaga aggcttatga aattcagaag
aacaaaccaa gaaatgatga tatttttaag 720 ataattatgg cagcaattgt
gcttttcttt ttcttttcct ggattcccca ccaaatattc 780 acttttctgg
atgtattgat tcaactaggc atcatacgtg actgtagaat tgcagatatt 840
gtggacacgg ccatgcctat caccatttgt atagcttatt ttaacaattg cctgaatcct
900 cttttttatg gctttctggg gaaaaaattt aaaagatatt ttctccagct
tctaaaatat 960 attcccccaa aagccaaatc ccactcaaac ctttcaacaa
aaatgagcac gctttcctac 1020 cgcccctcag ataatgtaag ctcatccacc
aagaagcctg caccatgttt tgaggttgag 1080 tga 1083 106 360 PRT Homo
sapiens 106 Met Ile Leu Asn Ser Ser Thr Glu Asp Gly Ile Lys Arg Ile
Gln Asp 1 5 10 15 Asp Cys Pro Lys Ala Gly Arg His Asn Tyr Ile Phe
Val Met Ile Pro 20 25 30 Thr Leu Tyr Ser Ile Ile Phe Val Val Gly
Ile Phe Gly Asn Ser Leu 35 40 45 Val Val Ile Val Ile Tyr Phe Tyr
Met Lys Leu Lys Thr Val Ala Ser 50 55 60 Val Phe Leu Leu Asn Leu
Ala Leu Ala Asp Leu Cys Phe Leu Leu Thr 65 70 75 80 Leu Pro Leu Trp
Ala Val Tyr Thr Ala Met Glu Tyr Arg Trp Pro Phe 85 90 95 Gly Asn
Tyr Leu Cys Lys Ile Ala Ser Ala Ser Val Ser Phe Asn Leu 100 105 110
Tyr Ala Ser Val Phe Leu Leu Thr Cys Leu Ser Ile Asp Arg Tyr Leu 115
120 125 Ala Ile Val His Pro Met Lys Ser Arg Leu Arg Arg Thr Met Leu
Val 130 135 140 Ala Lys Val Thr Cys Ile Ile Ile Trp Leu Leu Ala Gly
Leu Ala Ser 145 150 155 160 Leu Pro Ala Ile Ile His Arg Asn Val Phe
Phe Ile Glu Asn Thr Asn 165 170 175 Ile Thr Val Cys Ala Phe His Tyr
Glu Ser Gln Asn Ser Thr Leu Pro 180 185 190 Ile Gly Leu Gly Leu Thr
Lys Asn Ile Leu Gly Phe Leu Phe Pro Phe 195 200 205 Leu Ile Ile Leu
Thr Ser Tyr Thr Leu Ile Trp Lys Ala Leu Lys Lys 210 215 220 Ala Tyr
Glu Ile Gln Lys Asn Lys Pro Arg Asn Asp Asp Ile Phe Lys 225 230 235
240 Ile Ile Met Ala Ala Ile Val Leu Phe Phe Phe Phe Ser Trp Ile Pro
245 250 255 His Gln Ile Phe Thr Phe Leu Asp Val Leu Ile Gln Leu Gly
Ile Ile 260 265 270 Arg Asp Cys Arg Ile Ala Asp Ile Val Asp Thr Ala
Met Pro Ile Thr 275 280 285 Ile Cys Ile Ala Tyr Phe Asn Asn Cys Leu
Asn Pro Leu Phe Tyr Gly 290 295 300 Phe Leu Gly Lys Lys Phe Lys Arg
Tyr Phe Leu Gln Leu Leu Lys Tyr 305 310 315 320 Ile Pro Pro Lys Ala
Lys Ser His Ser Asn Leu Ser Thr Lys Met Ser 325 330 335 Thr Leu Ser
Tyr Arg Pro Ser Asp Asn Val Ser Ser Ser Thr Lys Lys 340 345 350 Pro
Ala Pro Cys Phe Glu Val Glu 355 360 107 26 DNA Artificial Sequence
Novel Sequence 107 cccaagcttc cccaggtgta tttgat 26 108 38 DNA
Artificial Sequence Novel Sequence 108 aagcacaatt gctgcataat
tatcttaaaa atatcatc 38 109 39 DNA Artificial Sequence Novel
Sequence 109 aagataatta tggcagcaat tgtgcttttc tttttcttt 39 110 26
DNA Artificial Sequence Novel Sequence 110 gttggatcca cataatgcat
tttctc 26 111 1344 DNA Homo sapiens 111 atggagctgc taaagctgaa
ccggagcgtg cagggaaccg gacccgggcc gggggcttcc 60 ctgtgccgcc
cgggggcgcc tctcctcaac agcagcagtg tgggcaacct cagctgcgag 120
ccccctcgca ttcgcggagc cgggacacga gaattggagc tggccattag aatcactctt
180 tacgcagtga tcttcctgat gagcgttgga ggaaatatgc tcatcatcgt
ggtcctggga 240 ctgagccgcc gcctgaggac tgtcaccaat gccttcctcc
tctcactggc agtcagcgac 300 ctcctgctgg ctgtggcttg catgcccttc
accctcctgc ccaatctcat gggcacattc 360 atctttggca ccgtcatctg
caaggcggtt tcctacctca tgggggtgtc tgtgagtgtg 420 tccacgctaa
gcctcgtggc catcgcactg gagcgatata gcgccatctg ccgaccactg 480
caggcacgag tgtggcagac gcgctcccac gcggctcgcg tgattgtagc cacgtggctg
540 ctgtccggac tactcatggt gccctacccc gtgtacactg tcgtgcaacc
agtggggcct 600 cgtgtgctgc agtgcgtgca tcgctggccc agtgcgcggg
tccgccagac ctggtccgta 660 ctgctgcttc tgctcttgtt cttcatccca
ggtgtggtta tggccgtggc ctacgggctt 720 atctctcgcg agctctactt
agggcttcgc tttgacggcg acagtgacag cgacagccaa 780 agcagggtcc
gaaaccaagg cgggctgcca ggggctgttc accagaacgg gcgttgccgg 840
cctgagactg gcgcggttgg caaagacagc gatggctgct acgtgcaact tccacgttcc
900 cggcctgccc tggagctgac ggcgctgacg gctcctgggc cgggatccgg
ctcccggccc 960 acccaggcca agctgctggc taagaagcgc gtgaaacgaa
tgttgctggt gatcgttgtg 1020 cttttttttc tgtgttggtt gccagtttat
agtgccaaca cgtggcgcgc ctttgatggc 1080 ccgggtgcac accgagcact
ctcgggtgct cctatctcct tcattcactt gctgagctac 1140 gcctcggcct
gtgtcaaccc cctggtctac tgcttcatgc accgtcgctt tcgccaggcc 1200
tgcctggaaa cttgcgctcg ctgctgcccc cggcctccac gagctcgccc cagggctctt
1260 cccgatgagg accctcccac tccctccatt gcttcgctgt ccaggcttag
ctacaccacc 1320 atcagcacac tgggccctgg ctga 1344 112 447 PRT Homo
sapiens 112 Met Glu Leu Leu Lys Leu Asn Arg Ser Val Gln Gly Thr Gly
Pro Gly 1 5 10 15 Pro Gly Ala Ser Leu Cys Arg Pro Gly Ala Pro Leu
Leu Asn Ser Ser 20 25 30 Ser Val Gly Asn Leu Ser Cys Glu Pro Pro
Arg Ile Arg Gly Ala Gly 35 40 45 Thr Arg Glu Leu Glu Leu Ala Ile
Arg Ile Thr Leu Tyr Ala Val Ile 50 55 60 Phe Leu Met Ser Val Gly
Gly Asn Met Leu Ile Ile Val Val Leu Gly 65 70 75 80 Leu Ser Arg Arg
Leu Arg Thr Val Thr Asn Ala Phe Leu Leu Ser Leu 85 90 95 Ala Val
Ser Asp Leu Leu Leu Ala Val Ala Cys Met Pro Phe Thr Leu 100 105 110
Leu Pro Asn Leu Met Gly Thr Phe Ile Phe Gly Thr Val Ile Cys Lys 115
120 125 Ala Val Ser Tyr Leu Met Gly Val Ser Val Ser Val Ser Thr Leu
Ser 130 135 140 Leu Val Ala Ile Ala Leu Glu Arg Tyr Ser Ala Ile Cys
Arg Pro Leu 145 150 155 160 Gln Ala Arg Val Trp Gln Thr Arg Ser His
Ala Ala Arg Val Ile Val 165 170 175 Ala Thr Trp Leu Leu Ser Gly Leu
Leu Met Val Pro Tyr Pro Val Tyr 180 185 190 Thr Val Val Gln Pro Val
Gly Pro Arg Val Leu Gln Cys Val His Arg 195 200 205 Trp Pro Ser Ala
Arg Val Arg Gln Thr Trp Ser Val Leu Leu Leu Leu 210 215 220 Leu Leu
Phe Phe Ile Pro Gly Val Val Met Ala Val Ala Tyr Gly Leu 225 230 235
240 Ile Ser Arg Glu Leu Tyr Leu Gly Leu Arg Phe Asp Gly Asp Ser Asp
245 250 255 Ser Asp Ser Gln Ser Arg Val Arg Asn Gln Gly Gly Leu Pro
Gly Ala 260 265 270 Val His Gln Asn Gly Arg Cys Arg Pro Glu Thr Gly
Ala Val Gly Lys 275 280 285 Asp Ser Asp Gly Cys Tyr Val Gln Leu Pro
Arg Ser Arg Pro Ala Leu 290 295 300 Glu Leu Thr Ala Leu Thr Ala Pro
Gly Pro Gly Ser Gly Ser Arg Pro 305 310 315 320 Thr Gln Ala Lys Leu
Leu Ala Lys Lys Arg Val Lys Arg Met Leu Leu 325 330 335 Val Ile Val
Val Leu Phe Phe Leu Cys Trp Leu Pro Val Tyr Ser Ala 340 345 350 Asn
Thr Trp Arg Ala Phe Asp Gly Pro Gly Ala His Arg Ala Leu Ser 355 360
365 Val Ala Pro Ile Ser Phe Ile His Leu Leu Ser Tyr Ala Ser Ala Cys
370 375 380 Val Asn Pro Leu Val Tyr Cys Phe Met His Arg Arg Phe Arg
Gln Ala 385 390 395 400 Cys Leu Glu Thr Cys Ala Arg Cys Cys Pro Arg
Pro Pro Arg Ala Arg 405 410 415 Pro Arg Ala Leu Pro Asp Glu Asp Pro
Pro Thr Pro Ser Ile Ala Ser 420 425 430 Leu Ser Arg Leu Ser Tyr Thr
Thr Ile Ser Thr Leu Gly Pro Gly 435 440 445 113 34 DNA Artificial
Sequence
Novel Sequence 113 cagcagcatg cgcttcacgc gcttcttagc ccag 34 114 35
DNA Artificial Sequence Novel Sequence 114 agaagcgcgt gaagcgcatg
ctgctggtga tcgtt 35 115 33 DNA Artificial Sequence Novel Sequence
115 atggagaaaa gaatcaaaag aatgttctat ata 33 116 33 DNA Artificial
Sequence Novel Sequence 116 tatatagaac attcttttga ttcttttctc cat 33
117 30 DNA Artificial Sequence Novel Sequence 117 cgctctctgg
ccttgaagcg cacgctcagc 30 118 30 DNA Artificial Sequence Novel
Sequence 118 gctgagcgtg cgcttcaagg ccagagagcg 30 119 30 DNA
Artificial Sequence Novel Sequence 119 cccaggaaaa aggtgaaagt
caaagttttc 30 120 30 DNA Artificial Sequence Novel Sequence 120
gaaaactttg actttcacct ttttcctggg 30 121 27 DNA Artificial Sequence
Novel Sequence 121 ggggcgcggg tgaaacggct ggtgagc 27 122 27 DNA
Artificial Sequence Novel Sequence 122 gctcaccagc cgtttcaccc
gcgcccc 27 123 30 DNA Artificial Sequence Novel Sequence 123
ccccttgaaa agcctaagaa cttggtcatc 30 124 30 DNA Artificial Sequence
Novel Sequence 124 gatgaccaag ttcttaggct tttcaagggg 30 125 32 DNA
Artificial Sequence Novel Sequence 125 gatctctaga atgaacagca
catgtattga ag 32 126 35 DNA Artificial Sequence Novel Sequence 126
ctagggtacc cgctcaagga cctctaattc catag 35 127 1296 DNA Homo sapiens
127 atgcaggcgc ttaacattac cccggagcag ttctctcggc tgctgcggga
ccacaacctg 60 acgcgggagc agttcatcgc tctgtaccgg ctgcgaccgc
tcgtctacac cccagagctg 120 ccgggacgcg ccaagctggc cctcgtgctc
accggcgtgc tcatcttcgc cctggcgctc 180 tttggcaatg ctctggtgtt
ctacgtggtg acccgcagca aggccatgcg caccgtcacc 240 aacatcttta
tctgctcctt ggcgctcagt gacctgctca tcaccttctt ctgcattccc 300
gtcaccatgc tccagaacat ttccgacaac tggctggggg gtgctttcat ttgcaagatg
360 gtgccatttg tccagtctac cgctgttgtg acagaaatgc tcactatgac
ctgcattgct 420 gtggaaaggc accagggact tgtgcatcct tttaaaatga
agtggcaata caccaaccga 480 agggctttca caatgctagg tgtggtctgg
ctggtggcag tcatcgtagg atcacccatg 540 tggcacgtgc aacaacttga
gatcaaatat gacttcctat atgaaaagga acacatctgc 600 tgcttagaag
agtggaccag ccctgtgcac cagaagatct acaccacctt catccttgtc 660
atcctcttcc tcctgcctct tatggtgatg cttattctgt acagtaaaat tggttatgaa
720 ctttggataa agaaaagagt tggggatggt tcagtgcttc gaactattca
tggaaaagaa 780 atgtccaaaa tagccaggaa gaagaaacga gctaagatta
tgatggtgac agtggtggct 840 ctctttgctg tgtgctgggc accattccat
gttgtccata tgatgattga atacagtaat 900 tttgaaaagg aatatgatga
tgtcacaatc aagatgattt ttgctatcgt gcaaattatt 960 ggattttcca
actccatctg taatcccatt gtctatgcat ttatgaatga aaacttcaaa 1020
aaaaatgttt tgtctgcagt ttgttattgc atagtaaata aaaccttctc tccagcacaa
1080 aggcatggaa attcaggaat tacaatgatg cggaagaaag caaagttttc
cctcagagag 1140 aatccagtgg aggaaaccaa aggagaagca ttcagtgatg
gcaacattga agtcaaattg 1200 tgtgaacaga cagaggagaa gaaaaagctc
aaacgacatc ttgctctctt taggtctgaa 1260 ctggctgaga attctccttt
agacagtggg cattaa 1296 128 431 PRT Homo sapiens 128 Met Gln Ala Leu
Asn Ile Thr Pro Glu Gln Phe Ser Arg Leu Leu Arg 1 5 10 15 Asp His
Asn Leu Thr Arg Glu Gln Phe Ile Ala Leu Tyr Arg Leu Arg 20 25 30
Pro Leu Val Tyr Thr Pro Glu Leu Pro Gly Arg Ala Lys Leu Ala Leu 35
40 45 Val Leu Thr Gly Val Leu Ile Phe Ala Leu Ala Leu Phe Gly Asn
Ala 50 55 60 Leu Val Phe Tyr Val Val Thr Arg Ser Lys Ala Met Arg
Thr Val Thr 65 70 75 80 Asn Ile Phe Ile Cys Ser Leu Ala Leu Ser Asp
Leu Leu Ile Thr Phe 85 90 95 Phe Cys Ile Pro Val Thr Met Leu Gln
Asn Ile Ser Asp Asn Trp Leu 100 105 110 Gly Gly Ala Phe Ile Cys Lys
Met Val Pro Phe Val Gln Ser Thr Ala 115 120 125 Val Val Thr Glu Met
Leu Thr Met Thr Cys Ile Ala Val Glu Arg His 130 135 140 Gln Gly Leu
Val His Pro Phe Lys Met Lys Trp Gln Tyr Thr Asn Arg 145 150 155 160
Arg Ala Phe Thr Met Leu Gly Val Val Trp Leu Val Ala Val Ile Val 165
170 175 Gly Ser Pro Met Trp His Val Gln Gln Leu Glu Ile Lys Tyr Asp
Phe 180 185 190 Leu Tyr Glu Lys Glu His Ile Cys Cys Leu Glu Glu Trp
Thr Ser Pro 195 200 205 Val His Gln Lys Ile Tyr Thr Thr Phe Ile Leu
Val Ile Leu Phe Leu 210 215 220 Leu Pro Leu Met Val Met Leu Ile Leu
Tyr Ser Lys Ile Gly Tyr Glu 225 230 235 240 Leu Trp Ile Lys Lys Arg
Val Gly Asp Gly Ser Val Leu Arg Thr Ile 245 250 255 His Gly Lys Glu
Met Ser Lys Ile Ala Arg Lys Lys Lys Arg Ala Lys 260 265 270 Ile Met
Met Val Thr Val Val Ala Leu Phe Ala Val Cys Trp Ala Pro 275 280 285
Phe His Val Val His Met Met Ile Glu Tyr Ser Asn Phe Glu Lys Glu 290
295 300 Tyr Asp Asp Val Thr Ile Lys Met Ile Phe Ala Ile Val Gln Ile
Ile 305 310 315 320 Gly Phe Ser Asn Ser Ile Cys Asn Pro Ile Val Tyr
Ala Phe Met Asn 325 330 335 Glu Asn Phe Lys Lys Asn Val Leu Ser Ala
Val Cys Tyr Cys Ile Val 340 345 350 Asn Lys Thr Phe Ser Pro Ala Gln
Arg His Gly Asn Ser Gly Ile Thr 355 360 365 Met Met Arg Lys Lys Ala
Lys Phe Ser Leu Arg Glu Asn Pro Val Glu 370 375 380 Glu Thr Lys Gly
Glu Ala Phe Ser Asp Gly Asn Ile Glu Val Lys Leu 385 390 395 400 Cys
Glu Gln Thr Glu Glu Lys Lys Lys Leu Lys Arg His Leu Ala Leu 405 410
415 Phe Arg Ser Glu Leu Ala Glu Asn Ser Pro Leu Asp Ser Gly His 420
425 430 129 2040 DNA Homo sapiens 129 atgggcagcc cctggaacgg
cagcgacggc cccgaggggg cgcgggagcc gccgtggccc 60 gcgctgccgc
cttgcgacga gcgccgctgc tcgccctttc ccctgggggc gctggtgccg 120
gtgaccgctg tgtgcctgtg cctgttcgtc gtcggggtga gcggcaacgt ggtgaccgtg
180 atgctgatcg ggcgctaccg ggacatgcgg accaccacca acttgtacct
gggcagcatg 240 gccgtgtccg acctactcat cctgctcggg ctgccgttcg
acctgtaccg cctctggcgc 300 tcgcggccct gggtgttcgg gccgctgctc
tgccgcctgt ccctctacgt gggcgagggc 360 tgcacctacg ccacgctgct
gcacatgacc gcgctcagcg tcgagcgcta cctggccatc 420 tgccgcccgc
tccgcgcccg cgtcttggtc acccggcgcc gcgtccgcgc gctcatcgct 480
gtgctctggg ccgtggcgct gctctctgcc ggtcccttct tgttcctggt gggcgtcgag
540 caggaccccg gcatctccgt agtcccgggc ctcaatggca ccgcgcggat
cgcctcctcg 600 cctctcgcct cgtcgccgcc tctctggctc tcgcgggcgc
caccgccgtc cccgccgtcg 660 gggcccgaga ccgcggaggc cgcggcgctg
ttcagccgcg aatgccggcc gagccccgcg 720 cagctgggcg cgctgcgtgt
catgctgtgg gtcaccaccg cctacttctt cctgcccttt 780 ctgtgcctca
gcatcctcta cgggctcatc gggcgggagc tgtggagcag ccggcggccg 840
ctgcgaggcc cggccgcctc ggggcgggag agaggccacc ggcagaccaa acgcgtcctg
900 cgtaagtgga gccgccgtgg ttccaaagac gcctgcctgc agtccgcccc
gccggggacc 960 gcgcaaacgc tgggtcccct tcccctgctc gcccagctct
gggcgccgct tccagctccc 1020 tttcctattt cgattccagc ctccacccgc
cggtacttcc catcccccga gaaaaccatg 1080 tcctgtcccc caggagctct
gggggacccc agggcgcttt gagggtggga tccccggatc 1140 cgattcagta
accagcagtg cttttccaga gcctctgaga ccagaaagga gagttggtaa 1200
ttcttaatcc aaccacctgt tagatgccac aaatgaggag tcctcacagt gctcttgaga
1260 agacgaggga gatttcatta agctaaaatt ttttatttaa tgttaagtga
tgctgaaggc 1320 taaagtaaac cttgctcgta tcaaaaagta aagattgtgc
agacctgttg tagaattctt 1380 ttcaacagag aacagaaaac ttgtctccga
agtgggtttg tggaaggaag cctgccaagg 1440 cggcttgttc agagaaattg
ctccttctgg tttatgtcca gccttgataa cacatatggg 1500 agcctactat
gcagttttaa agcaagtatc catgcagcct gcagcctggt cattttttct 1560
ggggtgagga tctgcctagg tagaagtttt ctctaattta ttttgctgtt acttgttatt
1620 gcagatggtt ccttgtcggg gtggggggtt tatttgcttc ccaatgcttt
tgttaatccc 1680 ggtgctgtgt cttatgttgc agtggtggtg gttctggcat
ttataatttg ctggttgccc 1740 ttccacgttg gcagaatcat ttacataaac
acggaagatt cgcggatgat gtacttctct 1800 cagtacttta acatcgtcgc
tctgcaactt ttctatctga gcgcatctat caacccaatc 1860 ctctacaacc
tcatttcaaa gaagtacaga gcggcggcct ttaaactgct gctcgcaagg 1920
aagtccaggc cgagaggctt ccacagaagc agggacactg cgggggaagt tgcaggggac
1980 actggaggag acacggtggg ctacaccgag acaagcgcta acgtgaagac
gatgggataa 2040 130 412 PRT Homo sapiens 130 Met Gly Ser Pro Trp
Asn Gly Ser Asp Gly Pro Glu Gly Ala Arg Glu 1 5 10 15 Pro Pro Trp
Pro Ala Leu Pro Pro Cys Asp Glu Arg Arg Cys Ser Pro 20 25 30 Phe
Pro Leu Gly Ala Leu Val Pro Val Thr Ala Val Cys Leu Cys Leu 35 40
45 Phe Val Val Gly Val Ser Gly Asn Val Val Thr Val Met Leu Ile Gly
50 55 60 Arg Tyr Arg Asp Met Arg Thr Thr Thr Asn Leu Tyr Leu Gly
Ser Met 65 70 75 80 Ala Val Ser Asp Leu Leu Ile Leu Leu Gly Leu Pro
Phe Asp Leu Tyr 85 90 95 Arg Leu Trp Arg Ser Arg Pro Trp Val Phe
Gly Pro Leu Leu Cys Arg 100 105 110 Leu Ser Leu Tyr Val Gly Glu Gly
Cys Thr Tyr Ala Thr Leu Leu His 115 120 125 Met Thr Ala Leu Ser Val
Glu Arg Tyr Leu Ala Ile Cys Arg Pro Leu 130 135 140 Arg Ala Arg Val
Leu Val Thr Arg Arg Arg Val Arg Ala Leu Ile Ala 145 150 155 160 Val
Leu Trp Ala Val Ala Leu Leu Ser Ala Gly Pro Phe Leu Phe Leu 165 170
175 Val Gly Val Glu Gln Asp Pro Gly Ile Ser Val Val Pro Gly Leu Asn
180 185 190 Gly Thr Ala Arg Ile Ala Ser Ser Pro Leu Ala Ser Ser Pro
Pro Leu 195 200 205 Trp Leu Ser Arg Ala Pro Pro Pro Ser Pro Pro Ser
Gly Pro Glu Thr 210 215 220 Ala Glu Ala Ala Ala Leu Phe Ser Arg Glu
Cys Arg Pro Ser Pro Ala 225 230 235 240 Gln Leu Gly Ala Leu Arg Val
Met Leu Trp Val Thr Thr Ala Tyr Phe 245 250 255 Phe Leu Pro Phe Leu
Cys Leu Ser Ile Leu Tyr Gly Leu Ile Gly Arg 260 265 270 Glu Leu Trp
Ser Ser Arg Arg Pro Leu Arg Gly Pro Ala Ala Ser Gly 275 280 285 Arg
Glu Arg Gly His Arg Gln Thr Lys Arg Val Leu Leu Val Val Val 290 295
300 Leu Ala Phe Ile Ile Cys Trp Leu Pro Phe His Val Gly Arg Ile Ile
305 310 315 320 Tyr Ile Asn Thr Glu Asp Ser Arg Met Met Tyr Phe Ser
Gln Tyr Phe 325 330 335 Asn Ile Val Ala Leu Gln Leu Phe Tyr Leu Ser
Ala Ser Ile Asn Pro 340 345 350 Ile Leu Tyr Asn Leu Ile Ser Lys Lys
Tyr Arg Ala Ala Ala Phe Lys 355 360 365 Leu Leu Leu Ala Arg Lys Ser
Arg Pro Arg Gly Phe His Arg Ser Arg 370 375 380 Asp Thr Ala Gly Glu
Val Ala Gly Asp Thr Gly Gly Asp Thr Val Gly 385 390 395 400 Tyr Thr
Glu Thr Ser Ala Asn Val Lys Thr Met Gly 405 410 131 1344 DNA Homo
sapiens 131 atggagctgc taaagctgaa ccggagcgtg cagggaaccg gacccgggcc
gggggcttcc 60 ctgtgccgcc cgggggcgcc tctcctcaac agcagcagtg
tgggcaacct cagctgcgag 120 ccccctcgca ttcgcggagc cgggacacga
gaattggagc tggccattag aatcactctt 180 tacgcagtga tcttcctgat
gagcgttgga ggaaatatgc tcatcatcgt ggtcctggga 240 ctgagccgcc
gcctgaggac tgtcaccaat gccttcctcc tctcactggc agtcagcgac 300
ctcctgctgg ctgtggcttg catgcccttc accctcctgc ccaatctcat gggcacattc
360 atctttggca ccgtcatctg caaggcggtt tcctacctca tgggggtgtc
tgtgagtgtg 420 tccacgctaa gcctcgtggc catcgcactg gagcgatata
gcgccatctg ccgaccactg 480 caggcacgag tgtggcagac gcgctcccac
gcggctcgcg tgattgtagc cacgtggctg 540 ctgtccggac tactcatggt
gccctacccc gtgtacactg tcgtgcaacc agtggggcct 600 cgtgtgctgc
agtgcgtgca tcgctggccc agtgcgcggg tccgccagac ctggtccgta 660
ctgctgcttc tgctcttgtt cttcatccca ggtgtggtta tggccgtggc ctacgggctt
720 atctctcgcg agctctactt agggcttcgc tttgacggcg acagtgacag
cgacagccaa 780 agcagggtcc gaaaccaagg cgggctgcca ggggctgttc
accagaacgg gcgttgccgg 840 cctgagactg gcgcggttgg caaagacagc
gatggctgct acgtgcaact tccacgttcc 900 cggcctgccc tggagctgac
ggcgctgacg gctcctgggc cgggatccgg ctcccggccc 960 acccaggcca
agctgctggc taagaagcgc gtgaaacgaa tgttgctggt gatcgttgtg 1020
cttttttttc tgtgttggtt gccagtttat agtgccaaca cgtggcgcgc ctttgatggc
1080 ccgggtgcac accgagcact ctcgggtgct cctatctcct tcattcactt
gctgagctac 1140 gcctcggcct gtgtcaaccc cctggtctac tgcttcatgc
accgtcgctt tcgccaggcc 1200 tgcctggaaa cttgcgctcg ctgctgcccc
cggcctccac gagctcgccc cagggctctt 1260 cccgatgagg accctcccac
tccctccatt gcttcgctgt ccaggcttag ctacaccacc 1320 atcagcacac
tgggccctgg ctga 1344 132 447 PRT Homo sapiens 132 Met Glu Leu Leu
Lys Leu Asn Arg Ser Val Gln Gly Thr Gly Pro Gly 1 5 10 15 Pro Gly
Ala Ser Leu Cys Arg Pro Gly Ala Pro Leu Leu Asn Ser Ser 20 25 30
Ser Val Gly Asn Leu Ser Cys Glu Pro Pro Arg Ile Arg Gly Ala Gly 35
40 45 Thr Arg Glu Leu Glu Leu Ala Ile Arg Ile Thr Leu Tyr Ala Val
Ile 50 55 60 Phe Leu Met Ser Val Gly Gly Asn Met Leu Ile Ile Val
Val Leu Gly 65 70 75 80 Leu Ser Arg Arg Leu Arg Thr Val Thr Asn Ala
Phe Leu Leu Ser Leu 85 90 95 Ala Val Ser Asp Leu Leu Leu Ala Val
Ala Cys Met Pro Phe Thr Leu 100 105 110 Leu Pro Asn Leu Met Gly Thr
Phe Ile Phe Gly Thr Val Ile Cys Lys 115 120 125 Ala Val Ser Tyr Leu
Met Gly Val Ser Val Ser Val Ser Thr Leu Ser 130 135 140 Leu Val Ala
Ile Ala Leu Glu Arg Tyr Ser Ala Ile Cys Arg Pro Leu 145 150 155 160
Gln Ala Arg Val Trp Gln Thr Arg Ser His Ala Ala Arg Val Ile Val 165
170 175 Ala Thr Trp Leu Leu Ser Gly Leu Leu Met Val Pro Tyr Pro Val
Tyr 180 185 190 Thr Val Val Gln Pro Val Gly Pro Arg Val Leu Gln Cys
Val His Arg 195 200 205 Trp Pro Ser Ala Arg Val Arg Gln Thr Trp Ser
Val Leu Leu Leu Leu 210 215 220 Leu Leu Phe Phe Ile Pro Gly Val Val
Met Ala Val Ala Tyr Gly Leu 225 230 235 240 Ile Ser Arg Glu Leu Tyr
Leu Gly Leu Arg Phe Asp Gly Asp Ser Asp 245 250 255 Ser Asp Ser Gln
Ser Arg Val Arg Asn Gln Gly Gly Leu Pro Gly Ala 260 265 270 Val His
Gln Asn Gly Arg Cys Arg Pro Glu Thr Gly Ala Val Gly Lys 275 280 285
Asp Ser Asp Gly Cys Tyr Val Gln Leu Pro Arg Ser Arg Pro Ala Leu 290
295 300 Glu Leu Thr Ala Leu Thr Ala Pro Gly Pro Gly Ser Gly Ser Arg
Pro 305 310 315 320 Thr Gln Ala Lys Leu Leu Ala Lys Lys Arg Val Lys
Arg Met Leu Leu 325 330 335 Val Ile Val Val Leu Phe Phe Leu Cys Trp
Leu Pro Val Tyr Ser Ala 340 345 350 Asn Thr Trp Arg Ala Phe Asp Gly
Pro Gly Ala His Arg Ala Leu Ser 355 360 365 Val Ala Pro Ile Ser Phe
Ile His Leu Leu Ser Tyr Ala Ser Ala Cys 370 375 380 Val Asn Pro Leu
Val Tyr Cys Phe Met His Arg Arg Phe Arg Gln Ala 385 390 395 400 Cys
Leu Glu Thr Cys Ala Arg Cys Cys Pro Arg Pro Pro Arg Ala Arg 405 410
415 Pro Arg Ala Leu Pro Asp Glu Asp Pro Pro Thr Pro Ser Ile Ala Ser
420 425 430 Leu Ser Arg Leu Ser Tyr Thr Thr Ile Ser Thr Leu Gly Pro
Gly 435 440 445 133 1014 DNA Homo sapiens 133 atgaacagca catgtattga
agaacagcat gacctggatc actatttgtt tcccattgtt 60 tacatctttg
tgattatagt cagcattcca gccaatattg gatctctgtg tgtgtctttc 120
ctgcaagcaa agaaggaaag tgaactagga atttacctct tcagtttgtc actatcagat
180 ttactctatg cattaactct ccctttatgg attgattata cttggaataa
agacaactgg 240 actttctctc ctgccttgtg caaagggagt gcttttctca
tgtacatgaa tttttacagc 300 agcacagcat tcctcacctg cattgccgtt
gatcggtatt tggctgttgt ctaccctttg 360 aagttttttt tcctaaggac
aagaagattt gcactcatgg tcagcctgtc catctggata 420 ttggaaacca
tcttcaatgc tgtcatgttg tgggaagatg aaacagttgt tgaatattgc 480
gatgccgaaa agtctaattt tactttatgc tatgacaaat accctttaga gaaatggcaa
540 atcaacctca acttgttcag gacgtgtaca ggctatgcaa tacctttggt
caccatcctg 600 atctgtaacc ggaaagtcta ccaagctgtg cggcacaata
aagccacgga aaacaaggaa 660 aagaagagaa tcaaaaaact acttgtcagc
atcacagtta cttttgtctt atgctttact 720 ccctttcatg tgatgttgct
gattcgctgc attttagagc atgctgtgaa cttcgaagac 780 cacagcaatt
ctgggaagcg aacttacaca
atgtatagaa tcacggttgc attaacaagt 840 ttaaattgtg ttgctgatcc
aattctgtac tgttttgtta ccgaaacagg aagatatgat 900 atgtggaata
tattaaaatt ctgcactggg aggtgtaata catcacaaag acaaagaaaa 960
cgcatacttt ctgtgtctac aaaagatact atggaattag aggtccttga gtag 1014
134 337 PRT Homo sapiens 134 Met Asn Ser Thr Cys Ile Glu Glu Gln
His Asp Leu Asp His Tyr Leu 1 5 10 15 Phe Pro Ile Val Tyr Ile Phe
Val Ile Ile Val Ser Ile Pro Ala Asn 20 25 30 Ile Gly Ser Leu Cys
Val Ser Phe Leu Gln Ala Lys Lys Glu Ser Glu 35 40 45 Leu Gly Ile
Tyr Leu Phe Ser Leu Ser Leu Ser Asp Leu Leu Tyr Ala 50 55 60 Leu
Thr Leu Pro Leu Trp Ile Asp Tyr Thr Trp Asn Lys Asp Asn Trp 65 70
75 80 Thr Phe Ser Pro Ala Leu Cys Lys Gly Ser Ala Phe Leu Met Tyr
Met 85 90 95 Asn Phe Tyr Ser Ser Thr Ala Phe Leu Thr Cys Ile Ala
Val Asp Arg 100 105 110 Tyr Leu Ala Val Val Tyr Pro Leu Lys Phe Phe
Phe Leu Arg Thr Arg 115 120 125 Arg Phe Ala Leu Met Val Ser Leu Ser
Ile Trp Ile Leu Glu Thr Ile 130 135 140 Phe Asn Ala Val Met Leu Trp
Glu Asp Glu Thr Val Val Glu Tyr Cys 145 150 155 160 Asp Ala Glu Lys
Ser Asn Phe Thr Leu Cys Tyr Asp Lys Tyr Pro Leu 165 170 175 Glu Lys
Trp Gln Ile Asn Leu Asn Leu Phe Arg Thr Cys Thr Gly Tyr 180 185 190
Ala Ile Pro Leu Val Thr Ile Leu Ile Cys Asn Arg Lys Val Tyr Gln 195
200 205 Ala Val Arg His Asn Lys Ala Thr Glu Asn Lys Glu Lys Lys Arg
Ile 210 215 220 Lys Lys Leu Leu Val Ser Ile Thr Val Thr Phe Val Leu
Cys Phe Thr 225 230 235 240 Pro Phe His Val Met Leu Leu Ile Arg Cys
Ile Leu Glu His Ala Val 245 250 255 Asn Phe Glu Asp His Ser Asn Ser
Gly Lys Arg Thr Tyr Thr Met Tyr 260 265 270 Arg Ile Thr Val Ala Leu
Thr Ser Leu Asn Cys Val Ala Asp Pro Ile 275 280 285 Leu Tyr Cys Phe
Val Thr Glu Thr Gly Arg Tyr Asp Met Trp Asn Ile 290 295 300 Leu Lys
Phe Cys Thr Gly Arg Cys Asn Thr Ser Gln Arg Gln Arg Lys 305 310 315
320 Arg Ile Leu Ser Val Ser Thr Lys Asp Thr Met Glu Leu Glu Val Leu
325 330 335 Glu 135 999 DNA Homo sapiens 135 atggtgaact ccacccaccg
tgggatgcac acttctctgc acctctggaa ccgcagcagt 60 tacagactgc
acagcaatgc cagtgagtcc cttggaaaag gctactctga tggagggtgc 120
tacgagcaac tttttgtctc tcctgaggtg tttgtgactc tgggtgtcat cagcttgttg
180 gagaatatct tagtgattgt ggcaatagcc aagaacaaga atctgcattc
acccatgtac 240 tttttcatct gcagcttggc tgtggctgat atgctggtga
gcgtttcaaa tggatcagaa 300 accattatca tcaccctatt aaacagtaca
gatacggatg cacagagttt cacagtgaat 360 attgataatg tcattgactc
ggtgatctgt agctccttgc ttgcatccat ttgcagcctg 420 ctttcaattg
cagtggacag gtactttact atcttctatg ctctccagta ccataacatt 480
atgacagtta agcgggttgg gatcagcata agttgtatct gggcagcttg cacggtttca
540 ggcattttgt tcatcattta ctcagatagt agtgctgtca tcatctgcct
catcaccatg 600 ttcttcacca tgctggctct catggcttct ctctatgtcc
acatgttcct gatggccagg 660 cttcacatta agaggattgc tgtcctcccc
ggcactggtg ccatccgcca aggtgccaat 720 atgaagggaa aaattacctt
gaccatcctg attggcgtct ttgttgtctg ctgggcccca 780 ttcttcctcc
acttaatatt ctacatctct tgtcctcaga atccatattg tgtgtgcttc 840
atgtctcact ttaacttgta tctcatactg atcatgtgta attcaatcat cgatcctctg
900 atttatgcac tccggagtca agaactgagg aaaaccttca aagagatcat
ctgttgctat 960 cccctgggag gcctttgtga cttgtctagc agatattaa 999 136
332 PRT Homo sapiens 136 Met Val Asn Ser Thr His Arg Gly Met His
Thr Ser Leu His Leu Trp 1 5 10 15 Asn Arg Ser Ser Tyr Arg Leu His
Ser Asn Ala Ser Glu Ser Leu Gly 20 25 30 Lys Gly Tyr Ser Asp Gly
Gly Cys Tyr Glu Gln Leu Phe Val Ser Pro 35 40 45 Glu Val Phe Val
Thr Leu Gly Val Ile Ser Leu Leu Glu Asn Ile Leu 50 55 60 Val Ile
Val Ala Ile Ala Lys Asn Lys Asn Leu His Ser Pro Met Tyr 65 70 75 80
Phe Phe Ile Cys Ser Leu Ala Val Ala Asp Met Leu Val Ser Val Ser 85
90 95 Asn Gly Ser Glu Thr Ile Ile Ile Thr Leu Leu Asn Ser Thr Asp
Thr 100 105 110 Asp Ala Gln Ser Phe Thr Val Asn Ile Asp Asn Val Ile
Asp Ser Val 115 120 125 Ile Cys Ser Ser Leu Leu Ala Ser Ile Cys Ser
Leu Leu Ser Ile Ala 130 135 140 Val Asp Arg Tyr Phe Thr Ile Phe Tyr
Ala Leu Gln Tyr His Asn Ile 145 150 155 160 Met Thr Val Lys Arg Val
Gly Ile Ser Ile Ser Cys Ile Trp Ala Ala 165 170 175 Cys Thr Val Ser
Gly Ile Leu Phe Ile Ile Tyr Ser Asp Ser Ser Ala 180 185 190 Val Ile
Ile Cys Leu Ile Thr Met Phe Phe Thr Met Leu Ala Leu Met 195 200 205
Ala Ser Leu Tyr Val His Met Phe Leu Met Ala Arg Leu His Ile Lys 210
215 220 Arg Ile Ala Val Leu Pro Gly Thr Gly Ala Ile Arg Gln Gly Ala
Asn 225 230 235 240 Met Lys Gly Lys Ile Thr Leu Thr Ile Leu Ile Gly
Val Phe Val Val 245 250 255 Cys Trp Ala Pro Phe Phe Leu His Leu Ile
Phe Tyr Ile Ser Cys Pro 260 265 270 Gln Asn Pro Tyr Cys Val Cys Phe
Met Ser His Phe Asn Leu Tyr Leu 275 280 285 Ile Leu Ile Met Cys Asn
Ser Ile Ile Asp Pro Leu Ile Tyr Ala Leu 290 295 300 Arg Ser Gln Glu
Leu Arg Lys Thr Phe Lys Glu Ile Ile Cys Cys Tyr 305 310 315 320 Pro
Leu Gly Gly Leu Cys Asp Leu Ser Ser Arg Tyr 325 330 137 33 DNA
Artificial Sequence Novel Sequence 137 gccaatatga agggaaaaat
taccttgacc atc 33 138 31 DNA Artificial Sequence Novel Sequence 138
ctccttcggt cctcctatcg ttgtcagaag t 31 139 1842 DNA Homo sapiens 139
atggggccca ccctagcggt tcccaccccc tatggctgta ttggctgtaa gctaccccag
60 ccagaatacc caccggctct aatcatcttt atgttctgcg cgatggttat
caccatcgtt 120 gtagacctaa tcggcaactc catggtcatt ttggctgtga
cgaagaacaa gaagctccgg 180 aattctggca acatcttcgt ggtcagtctc
tctgtggccg atatgctggt ggccatctac 240 ccataccctt tgatgctgca
tgccatgtcc attgggggct gggatctgag ccagttacag 300 tgccagatgg
tcgggttcat cacagggctg agtgtggtcg gctccatctt caacatcgtg 360
gcaatcgcta tcaaccgtta ctgctacatc tgccacagcc tccagtacga acggatcttc
420 agtgtgcgca atacctgcat ctacctggtc atcacctgga tcatgaccgt
cctggctgtc 480 ctgcccaaca tgtacattgg caccatcgag tacgatcctc
gcacctacac ctgcatcttc 540 aactatctga acaaccctgt cttcactgtt
accatcgtct gcatccactt cgtcctccct 600 ctcctcatcg tgggtttctg
ctacgtgagg atctggacca aagtgctggc ggcccgtgac 660 cctgcagggc
agaatcctga caaccaactt gctgaggttc gcaattttct aaccatgttt 720
gtgatcttcc tcctctttgc agtgtgctgg tgccctatca acgtgctcac tgtcttggtg
780 gctgtcagtc cgaaggagat ggcaggcaag atccccaact ggctttatct
tgcagcctac 840 ttcatagcct acttcaacag ctgcctcaac gctgtgatct
acgggctcct caatgagaat 900 ttccgaagag aatactggac catcttccat
gctatgcggc accctatcat attcttccct 960 ggcctcatca gtgatattcg
tgagatgcag gaggcccgta ccctggcccg cgcccgtgcc 1020 catgctcgcg
accaagctcg tgaacaagac cgtgcccatg cctgtcctgc tgtggaggaa 1080
accccgatga atgtccggaa tgttccatta cctggtgatg ctgcagctgg ccaccccgac
1140 cgtgcctctg gccaccctaa gccccattcc agatcctcct ctgcctatcg
caaatctgcc 1200 tctacccacc acaagtctgt ctttagccac tccaaggctg
cctctggtca cctcaagcct 1260 gtctctggcc actccaagcc tgcctctggt
caccccaagt ctgccactgt ctaccctaag 1320 cctgcctctg tccatttcaa
gggtgactct gtccatttca agggtgactc tgtccatttc 1380 aagcctgact
ctgttcattt caagcctgct tccagcaacc ccaagcccat cactggccac 1440
catgtctctg ctggcagcca ctccaagtct gccttcagtg ctgccaccag ccaccctaaa
1500 cccatcaagc cagctaccag ccatgctgag cccaccactg ctgactatcc
caagcctgcc 1560 actaccagcc accctaagcc cgctgctgct gacaaccctg
agctctctgc ctcccattgc 1620 cccgagatcc ctgccattgc ccaccctgtg
tctgacgaca gtgacctccc tgagtcggcc 1680 tctagccctg ccgctgggcc
caccaagcct gctgccagcc agctggagtc tgacaccatc 1740 gctgaccttc
ctgaccctac tgtagtcact accagtacca atgattacca tgatgtcgtg 1800
gttgttgatg ttgaagatga tcctgatgaa atggctgtgt ga 1842 140 613 PRT
Homo sapiens 140 Met Gly Pro Thr Leu Ala Val Pro Thr Pro Tyr Gly
Cys Ile Gly Cys 1 5 10 15 Lys Leu Pro Gln Pro Glu Tyr Pro Pro Ala
Leu Ile Ile Phe Met Phe 20 25 30 Cys Ala Met Val Ile Thr Ile Val
Val Asp Leu Ile Gly Asn Ser Met 35 40 45 Val Ile Leu Ala Val Thr
Lys Asn Lys Lys Leu Arg Asn Ser Gly Asn 50 55 60 Ile Phe Val Val
Ser Leu Ser Val Ala Asp Met Leu Val Ala Ile Tyr 65 70 75 80 Pro Tyr
Pro Leu Met Leu His Ala Met Ser Ile Gly Gly Trp Asp Leu 85 90 95
Ser Gln Leu Gln Cys Gln Met Val Gly Phe Ile Thr Gly Leu Ser Val 100
105 110 Val Gly Ser Ile Phe Asn Ile Val Ala Ile Ala Ile Asn Arg Tyr
Cys 115 120 125 Tyr Ile Cys His Ser Leu Gln Tyr Glu Arg Ile Phe Ser
Val Arg Asn 130 135 140 Thr Cys Ile Tyr Leu Val Ile Thr Trp Ile Met
Thr Val Leu Ala Val 145 150 155 160 Leu Pro Asn Met Tyr Ile Gly Thr
Ile Glu Tyr Asp Pro Arg Thr Tyr 165 170 175 Thr Cys Ile Phe Asn Tyr
Leu Asn Asn Pro Val Phe Thr Val Thr Ile 180 185 190 Val Cys Ile His
Phe Val Leu Pro Leu Leu Ile Val Gly Phe Cys Tyr 195 200 205 Val Arg
Ile Trp Thr Lys Val Leu Ala Ala Arg Asp Pro Ala Gly Gln 210 215 220
Asn Pro Asp Asn Gln Leu Ala Glu Val Arg Asn Phe Leu Thr Met Phe 225
230 235 240 Val Ile Phe Leu Leu Phe Ala Val Cys Trp Cys Pro Ile Asn
Val Leu 245 250 255 Thr Val Leu Val Ala Val Ser Pro Lys Glu Met Ala
Gly Lys Ile Pro 260 265 270 Asn Trp Leu Tyr Leu Ala Ala Tyr Phe Ile
Ala Tyr Phe Asn Ser Cys 275 280 285 Leu Asn Ala Val Ile Tyr Gly Leu
Leu Asn Glu Asn Phe Arg Arg Glu 290 295 300 Tyr Trp Thr Ile Phe His
Ala Met Arg His Pro Ile Ile Phe Phe Pro 305 310 315 320 Gly Leu Ile
Ser Asp Ile Arg Glu Met Gln Glu Ala Arg Thr Leu Ala 325 330 335 Arg
Ala Arg Ala His Ala Arg Asp Gln Ala Arg Glu Gln Asp Arg Ala 340 345
350 His Ala Cys Pro Ala Val Glu Glu Thr Pro Met Asn Val Arg Asn Val
355 360 365 Pro Leu Pro Gly Asp Ala Ala Ala Gly His Pro Asp Arg Ala
Ser Gly 370 375 380 His Pro Lys Pro His Ser Arg Ser Ser Ser Ala Tyr
Arg Lys Ser Ala 385 390 395 400 Ser Thr His His Lys Ser Val Phe Ser
His Ser Lys Ala Ala Ser Gly 405 410 415 His Leu Lys Pro Val Ser Gly
His Ser Lys Pro Ala Ser Gly His Pro 420 425 430 Lys Ser Ala Thr Val
Tyr Pro Lys Pro Ala Ser Val His Phe Lys Gly 435 440 445 Asp Ser Val
His Phe Lys Gly Asp Ser Val His Phe Lys Pro Asp Ser 450 455 460 Val
His Phe Lys Pro Ala Ser Ser Asn Pro Lys Pro Ile Thr Gly His 465 470
475 480 His Val Ser Ala Gly Ser His Ser Lys Ser Ala Phe Ser Ala Ala
Thr 485 490 495 Ser His Pro Lys Pro Ile Lys Pro Ala Thr Ser His Ala
Glu Pro Thr 500 505 510 Thr Ala Asp Tyr Pro Lys Pro Ala Thr Thr Ser
His Pro Lys Pro Ala 515 520 525 Ala Ala Asp Asn Pro Glu Leu Ser Ala
Ser His Cys Pro Glu Ile Pro 530 535 540 Ala Ile Ala His Pro Val Ser
Asp Asp Ser Asp Leu Pro Glu Ser Ala 545 550 555 560 Ser Ser Pro Ala
Ala Gly Pro Thr Lys Pro Ala Ala Ser Gln Leu Glu 565 570 575 Ser Asp
Thr Ile Ala Asp Leu Pro Asp Pro Thr Val Val Thr Thr Ser 580 585 590
Thr Asn Asp Tyr His Asp Val Val Val Val Asp Val Glu Asp Asp Pro 595
600 605 Asp Glu Met Ala Val 610 141 1842 DNA Homo sapiens 141
atggggccca ccctagcggt tcccaccccc tatggctgta ttggctgtaa gctaccccag
60 ccagaatacc caccggctct aatcatcttt atgttctgcg cgatggttat
caccatcgtt 120 gtagacctaa tcggcaactc catggtcatt ttggctgtga
cgaagaacaa gaagctccgg 180 aattctggca acatcttcgt ggtcagtctc
tctgtggccg atatgctggt ggccatctac 240 ccataccctt tgatgctgca
tgccatgtcc attgggggct gggatctgag ccagttacag 300 tgccagatgg
tcgggttcat cacagggctg agtgtggtcg gctccatctt caacatcgtg 360
gcaatcgcta tcaaccgtta ctgctacatc tgccacagcc tccagtacga acggatcttc
420 agtgtgcgca atacctgcat ctacctggtc atcacctgga tcatgaccgt
cctggctgtc 480 ctgcccaaca tgtacattgg caccatcgag tacgatcctc
gcacctacac ctgcatcttc 540 aactatctga acaaccctgt cttcactgtt
accatcgtct gcatccactt cgtcctccct 600 ctcctcatcg tgggtttctg
ctacgtgagg atctggacca aagtgctggc ggcccgtgac 660 cctgcagggc
agaatcctga caaccaactt gctgaggttc gcaataaact aaccatgttt 720
gtgatcttcc tcctctttgc agtgtgctgg tgccctatca acgtgctcac tgtcttggtg
780 gctgtcagtc cgaaggagat ggcaggcaag atccccaact ggctttatct
tgcagcctac 840 ttcatagcct acttcaacag ctgcctcaac gctgtgatct
acgggctcct caatgagaat 900 ttccgaagag aatactggac catcttccat
gctatgcggc accctatcat attcttctct 960 ggcctcatca gtgatattcg
tgagatgcag gaggcccgta ccctggcccg cgcccgtgcc 1020 catgctcgcg
accaagctcg tgaacaagac cgtgcccatg cctgtcctgc tgtggaggaa 1080
accccgatga atgtccggaa tgttccatta cctggtgatg ctgcagctgg ccaccccgac
1140 cgtgcctctg gccaccctaa gccccattcc agatcctcct ctgcctatcg
caaatctgcc 1200 tctacccacc acaagtctgt ctttagccac tccaaggctg
cctctggtca cctcaagcct 1260 gtctctggcc actccaagcc tgcctctggt
caccccaagt ctgccactgt ctaccctaag 1320 cctgcctctg tccatttcaa
ggctgactct gtccatttca agggtgactc tgtccatttc 1380 aagcctgact
ctgttcattt caagcctgct tccagcaacc ccaagcccat cactggccac 1440
catgtctctg ctggcagcca ctccaagtct gccttcaatg ctgccaccag ccaccctaaa
1500 cccatcaagc cagctaccag ccatgctgag cccaccactg ctgactatcc
caagcctgcc 1560 actaccagcc accctaagcc cgctgctgct gacaaccctg
agctctctgc ctcccattgc 1620 cccgagatcc ctgccattgc ccaccctgtg
tctgacgaca gtgacctccc tgagtcggcc 1680 tctagccctg ccgctgggcc
caccaagcct gctgccagcc agctggagtc tgacaccatc 1740 gctgaccttc
ctgaccctac tgtagtcact accagtacca atgattacca tgatgtcgtg 1800
gttgttgatg ttgaagatga tcctgatgaa atggctgtgt ga 1842 142 613 PRT
Homo sapiens 142 Met Gly Pro Thr Leu Ala Val Pro Thr Pro Tyr Gly
Cys Ile Gly Cys 1 5 10 15 Lys Leu Pro Gln Pro Glu Tyr Pro Pro Ala
Leu Ile Ile Phe Met Phe 20 25 30 Cys Ala Met Val Ile Thr Ile Val
Val Asp Leu Ile Gly Asn Ser Met 35 40 45 Val Ile Leu Ala Val Thr
Lys Asn Lys Lys Leu Arg Asn Ser Gly Asn 50 55 60 Ile Phe Val Val
Ser Leu Ser Val Ala Asp Met Leu Val Ala Ile Tyr 65 70 75 80 Pro Tyr
Pro Leu Met Leu His Ala Met Ser Ile Gly Gly Trp Asp Leu 85 90 95
Ser Gln Leu Gln Cys Gln Met Val Gly Phe Ile Thr Gly Leu Ser Val 100
105 110 Val Gly Ser Ile Phe Asn Ile Val Ala Ile Ala Ile Asn Arg Tyr
Cys 115 120 125 Tyr Ile Cys His Ser Leu Gln Tyr Glu Arg Ile Phe Ser
Val Arg Asn 130 135 140 Thr Cys Ile Tyr Leu Val Ile Thr Trp Ile Met
Thr Val Leu Ala Val 145 150 155 160 Leu Pro Asn Met Tyr Ile Gly Thr
Ile Glu Tyr Asp Pro Arg Thr Tyr 165 170 175 Thr Cys Ile Phe Asn Tyr
Leu Asn Asn Pro Val Phe Thr Val Thr Ile 180 185 190 Val Cys Ile His
Phe Val Leu Pro Leu Leu Ile Val Gly Phe Cys Tyr 195 200 205 Val Arg
Ile Trp Thr Lys Val Leu Ala Ala Arg Asp Pro Ala Gly Gln 210 215 220
Asn Pro Asp Asn Gln Leu Ala Glu Val Arg Asn Lys Leu Thr Met Phe 225
230 235 240 Val Ile Phe Leu Leu Phe Ala Val Cys Trp Cys Pro Ile Asn
Val Leu 245 250 255 Thr Val Leu Val Ala Val Ser Pro Lys Glu Met Ala
Gly Lys Ile Pro 260 265 270 Asn Trp Leu Tyr Leu Ala Ala Tyr Phe Ile
Ala Tyr Phe Asn Ser Cys 275 280 285 Leu Asn Ala Val Ile Tyr Gly Leu
Leu Asn Glu Asn Phe Arg Arg Glu 290 295 300 Tyr Trp Thr Ile
Phe His Ala Met Arg His Pro Ile Ile Phe Phe Ser 305 310 315 320 Gly
Leu Ile Ser Asp Ile Arg Glu Met Gln Glu Ala Arg Thr Leu Ala 325 330
335 Arg Ala Arg Ala His Ala Arg Asp Gln Ala Arg Glu Gln Asp Arg Ala
340 345 350 His Ala Cys Pro Ala Val Glu Glu Thr Pro Met Asn Val Arg
Asn Val 355 360 365 Pro Leu Pro Gly Asp Ala Ala Ala Gly His Pro Asp
Arg Ala Ser Gly 370 375 380 His Pro Lys Pro His Ser Arg Ser Ser Ser
Ala Tyr Arg Lys Ser Ala 385 390 395 400 Ser Thr His His Lys Ser Val
Phe Ser His Ser Lys Ala Ala Ser Gly 405 410 415 His Leu Lys Pro Val
Ser Gly His Ser Lys Pro Ala Ser Gly His Pro 420 425 430 Lys Ser Ala
Thr Val Tyr Pro Lys Pro Ala Ser Val His Phe Lys Ala 435 440 445 Asp
Ser Val His Phe Lys Gly Asp Ser Val His Phe Lys Pro Asp Ser 450 455
460 Val His Phe Lys Pro Ala Ser Ser Asn Pro Lys Pro Ile Thr Gly His
465 470 475 480 His Val Ser Ala Gly Ser His Ser Lys Ser Ala Phe Asn
Ala Ala Thr 485 490 495 Ser His Pro Lys Pro Ile Lys Pro Ala Thr Ser
His Ala Glu Pro Thr 500 505 510 Thr Ala Asp Tyr Pro Lys Pro Ala Thr
Thr Ser His Pro Lys Pro Ala 515 520 525 Ala Ala Asp Asn Pro Glu Leu
Ser Ala Ser His Cys Pro Glu Ile Pro 530 535 540 Ala Ile Ala His Pro
Val Ser Asp Asp Ser Asp Leu Pro Glu Ser Ala 545 550 555 560 Ser Ser
Pro Ala Ala Gly Pro Thr Lys Pro Ala Ala Ser Gln Leu Glu 565 570 575
Ser Asp Thr Ile Ala Asp Leu Pro Asp Pro Thr Val Val Thr Thr Ser 580
585 590 Thr Asn Asp Tyr His Asp Val Val Val Val Asp Val Glu Asp Asp
Pro 595 600 605 Asp Glu Met Ala Val 610 143 33 DNA Artificial
Sequence Novel Sequence 143 gctgaggttc gcaataaact aaccatgttt gtg 33
144 31 DNA Artificial Sequence Novel Sequence 144 ctccttcggt
cctcctatcg ttgtcagaag t 31 145 27 DNA Artificial Sequence Novel
Sequence 145 ttagatatcg gggcccaccc tagcggt 27 146 29 DNA Artificial
Sequence Novel Sequence 146 ggtaccccca cagccatttc atcaggatc 29 147
31 DNA Artificial Sequence Novel Sequence 147 gatctggagt accccattga
cgtcaatggg g 31 148 31 DNA Artificial Sequence Novel Sequence 148
gatcccccat tgacgtcaat ggggtactcc a 31
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