U.S. patent application number 10/822010 was filed with the patent office on 2005-10-13 for skin lightening composition.
Invention is credited to Ho, Thienna.
Application Number | 20050226827 10/822010 |
Document ID | / |
Family ID | 35060766 |
Filed Date | 2005-10-13 |
United States Patent
Application |
20050226827 |
Kind Code |
A1 |
Ho, Thienna |
October 13, 2005 |
Skin lightening composition
Abstract
A skin lightening composition for lightening the natural skin
color of a user, and for treating disorders of hyperpigmentation.
The active ingredient is methyl sulfonyl methane (MSM), a naturally
occurring sulfur compound which may be safely administered
topically or orally and which is highly effective for decreasing
the ratio of dark melanin to light melanin, and thereby lightening
the skin color of a user. The skin lightening composition
additionally comprises a liquid solution or a cosmetic carrier such
as a cream, a lotion, or a gel, for ease of topical application.
Additionally, the skin lightening composition is provided in liquid
or solid form for oral ingestion. Topical preparations of the skin
lightening composition contain MSM in an amount equal to
approximately 1 to 20 weight percent MSM relative to the weight of
the entire composition. Orally ingestible preparations of the skin
lightening composition contain approximately 200 mg to 5000 mg MSM
per serving.
Inventors: |
Ho, Thienna; (San Francisco,
CA) |
Correspondence
Address: |
O'MELVENY & MYERS LLP
400 SOUTH HOPE STREET
LOS ANGELES
CA
90071-2899
US
|
Family ID: |
35060766 |
Appl. No.: |
10/822010 |
Filed: |
April 9, 2004 |
Current U.S.
Class: |
424/62 |
Current CPC
Class: |
A61P 17/00 20180101;
A61K 8/46 20130101; A61K 2800/92 20130101; A61Q 19/04 20130101 |
Class at
Publication: |
424/062 |
International
Class: |
A61K 007/135 |
Claims
What is claimed is:
1. A topical preparation of a skin lightening composition, suitable
for direct application to the face and body of a user, for
lightening the natural skin color of the user and for treating
disorders of hyperpigmentation, comprising: methyl sulfonyl
methane, a naturally occurring sulfur compound which lightens the
skin; and a vehicle; and wherein the methyl sulfonyl methane is
dissolved within the vehicle at an amount equal to approximately 1
to 20 weight percent methyl sulfonyl methane relative to the weight
of the entire skin lightening composition.
2. The topical preparation of a skin lightening composition as
recited in claim 1, wherein the vehicle is a liquid solution.
3. The topical preparation of a skin lightening composition as
recited in claim 2, further comprising a perfume.
4. The topical preparation of a skin lightening composition as
recited in claim 3, further comprising a nutrient chosen from a
class of nutrients consisting of vitamins and minerals.
5. The topical preparation of a skin lightening composition as
recited in claim 1, wherein the vehicle is a cosmetic carrier
chosen from a class of cosmetic carriers consisting of creams,
lotions, and gels, wherein the methyl sulfonyl methane is blended
within said cosmetic carrier at an amount equal to approximately 1
to 20 weight percent methyl sulfonyl methane relative to the weight
of the entire skin lightening composition.
6. The topical preparation of a skin lightening composition as
recited in claim 5, further comprising a perfume.
7. The topical preparation of a skin lightening composition as
recited in claim 6, further comprising a nutrient chosen from a
class of nutrients consisting of vitamins and minerals.
8. An orally ingestible preparation of a skin lightening
composition, comprising: approximately 200 mg to 5000 mg methyl
sulfonyl methane per serving; and an edible form chosen from a
class of edible forms consisting of tablets, pills, capsules, and
powders; and wherein the methyl sulfonyl methane is contained
within the edible form.
9. The orally ingestible preparation of a skin whitening formula as
recited in claim 8, further comprising at least one nutrient chosen
from a class of nutrients consisting of vitamins, minerals,
antioxidants, proteins, and amino acids, and wherein said at least
one nutrient is contained within the edible form.
10. A method for lightening the natural skin color of a user and
for treating disorders of hyperpigmentation, utilizing a topical
preparation of a skin lightening composition comprising methyl
sulfonyl methane and a vehicle, wherein the methyl sulfonyl methane
is dissolved within the vehicle at an amount equal to approximately
1 to 20 weight percent methyl sulfonyl methane relative to the
weight of the entire skin lightening composition, said method
comprising the step of directly applying the skin lightening
composition to the face and body of a user, and thereby lightening
the skin of the face and the body.
Description
BACKGROUND OF THE INVENTION
[0001] 1. Field of the Invention
[0002] The invention generally relates to a composition of matter,
and in particular relates to a skin lightening composition for
lightening the natural skin color of a user, and also for treating
disorders of hyperpigmentation.
[0003] 2. Description of the Related Art
[0004] Skin lighteners are used by millions of individuals for
lightening their natural skin color for cosmetic reasons. Skin
lighteners are also useful for treating the excessively dark skin
color caused by a dermatological condition known as
hyperpigmentation, characterized by abnormally increased
pigmentation. A number of compounds are known to lighten skin tone
when applied topically. The most popular of these is hydroquinone,
which is safe, effective, and available without a prescription.
Despite its overall safety and effectiveness, hydroquinone has been
known to cause dermatological ochronosis, a progressive
discoloration and degeneration of the skin, when used over an
extended period of time.
[0005] Alternative compounds for lightening skin color are
available. However, most of the synthetic or herbal compounds
discovered have side effects and are not as effective as
hydroquinone. Accordingly, there is a need for a skin lightening
composition comprising methyl sulfonyl methane, a nontoxic, natural
metabolite which is effective for lightening the natural skin color
of a user and for treating disorders of hyperpigmentation, and
which has no side effects.
[0006] A variety of formulations have been devised for lightening
skin, some which do not utilize hydroquinone. For example, U.S.
Pat. No. 6,497,860 to Kawato appears to show a skin lightening
composition comprising a reducing agent and a cosmetically
acceptable carrier for the reducing agent, and which is
substantially free of hydroquinone.
[0007] A variety of formulations have been devised which contain
methyl sulfonyl methane. By way of example, U.S. Pat. No. 6,328,987
to Marini appears to show a skin care composition for improving the
appearance of aged or damaged skin, containing alpha interferon and
optionally containing methyl sulfonyl methane. Additionally, U.S.
Pat. No. 4,296,130 to Herschler appears to show a method for
softening skin and strengthening nails, comprising topically
applying methyl sulfonyl methane to the skin and nails.
Furthermore, U.S. Pat. No. 6,573,299 to Petrus appears to show a
method for the prevention and treatment of the aging eye by the
application of a topical composition which optionally comprises
methyl sulfonyl methane. Also, U.S. Pat. No. 4,477,469 to Herschler
appears to show a preparation containing methyl sulfonyl methane
that is applied topically, for softening skin and strengthening
nails.
[0008] While these formulations and methods of using formulations
may be suitable for the particular purpose employed, or for general
use, they would not be as suitable for the purposes of the present
invention as disclosed hereafter.
SUMMARY OF THE INVENTION
[0009] It is an object of the invention to provide a skin
lightening composition which is effective in lightening the natural
skin color of a user and for treating disorders of
hyperpigmentation, and which is safe when topically applied to
human skin. Accordingly, the active ingredient of the skin
lightening composition is methyl sulfonyl methane, which is highly
effective in lightening the natural skin color of a user and for
treating disorders of hyperpigmentation, and which is safe when
topically applied to human skin.
[0010] It is another object of the invention to provide a skin
lightening composition that is also safe and effective when orally
ingested. Accordingly, methyl sulfonyl methane is a natural
metabolite found in the human body, is nontoxic, and is suitable
for long-term use by oral ingestion.
[0011] It is yet another object of this invention to provide a skin
lightening composition suitable for use with a wide variety of
different cosmetic "carriers", for ease of application to a user's
skin. Accordingly, topical preparations of the skin lightening
composition may be dissolved in a liquid solution, or in a carrier
such as a cream, a lotion, or a gel. (Orally ingestible
preparations may be in liquid, tablet, capsule, or powder
form).
[0012] The invention is a skin lightening composition for
lightening the natural skin color of a user, and for treating
disorders of hyperpigmentation. The active ingredient is methyl
sulfonyl methane (MSM), a naturally occurring sulfur compound which
may be safely administered topically or orally and which is highly
effective for decreasing the ratio of dark melanin to light
melanin, and thereby lightening the skin color of a user. The skin
lightening composition additionally comprises a liquid solution or
a cosmetic carrier such as a cream, a lotion, or a gel, for ease of
topical application. Additionally, the skin lightening composition
is provided in liquid or solid form for oral ingestion. Topical
preparations of the skin lightening composition contain MSM in an
amount equal to approximately 1 to 20 weight percent MSM relative
to the weight of the entire composition. Orally ingestible
preparations of the skin lightening composition contain
approximately 200 mg to 5000 mg MSM per serving.
[0013] To the accomplishment of the above and related objects the
invention may be embodied in the form described in the following
description. Attention is called to the fact, however, that the
examples given are illustrative only. Variations are contemplated
as being part of the invention.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
[0014] The skin lightening composition according to the present
invention is safe and effective for lightening the natural skin
color of a user, and also for treating disorders of
hyperpigmentation, which are characterized by abnormally increased
pigmentation. The active ingredient of the skin lightening
composition is methyl sulfonyl methane (MSM), a naturally occurring
sulfur compound found in the tissues and body fluids of higher
mammals, and in fresh fruits and vegetables, meat, milk, seafood,
and grains. Sulfur helps the body maintain the three dimensional
conformation of proteins required for their proper activity. Sulfur
is required for cell regeneration and collagen production in
connective tissues of the skin, and in muscles, cartilage, organs
and bone. MSM affects the synthesis of the melanin pigments, as
will be described.
[0015] Melanin is the pigment that largely determines skin color,
and is synthesized by the melanocytes in the basal layer of the
epidermis. There are two melanin pigments, eumelanin and
pheomelanin. Eumelanin is black and pheomelanin is yellow. The
ratio of these two pigments in the skin determines how dark or
light the skin will be. The synthesis of eumelanin and pheomelanin
requires the amino acid tyrosine and the enzyme tyrosinase.
Tyrosinase catalyzes the conversion of tyrosine into biochemical
intermediates dopa and dopaquinone. Dopaquinone is the precursor of
both eumelanin and pheomelanin in the process of melanogenesis, the
biochemical processes which synthesize the melanins. Differences in
the ratio of melanin pigments create wide variations in human skin
color, ranging from "white" skin color to "black" skin color.
Darker skinned individuals have a higher eumelanin to pheomelanin
ratio. To lighten skin color, the skin lightening composition
targets melanogenesis. In particular, MSM causes dopaquinone to be
diverted towards the production of pheomelanin, rather than
eumelanin, by safely and effectively increasing intracellular
sulfur levels. Under a high intracellular sulfur concentration,
melanogenesis automatically leads to an increased synthesis of
sulfhydryl-dopa conjugates resulting in the synthesis of the
lighter colored pheomelanin instead of the darker colored
eumelanin, which is the basis of the activity of MSM in the skin
lightening composition.
[0016] MSM has been previously used in supplements for treating
acne, arthritis, muscle pain, and skin damage and aging. MSM can be
used safely and effectively for lightening the natural skin color
of a user and for treating disorders of hyperpigmentation. Methyl
sulfonyl methane is all natural, nontoxic, non-allergenic, and
non-pyretic, and is safe and effective when administered topically
or when orally ingested, even over prolonged periods of time.
Moreover, MSM has no undesirable pharmacological effects when taken
in conjunction with other substances.
[0017] The skin lightening composition is provided in two types of
preparations. In particular, the skin lightening composition is
provided in topical preparations which are applied directly to the
skin, and also in orally ingestible preparations. Topical
preparations of the skin lightening composition comprise MSM
dissolved or mixed within a vehicle. The vehicle may be a liquid
solution, or it may be a cosmetic carrier such as a cream, a
lotion, or a gel. Topical preparations of the skin lightening
composition contain MSM at an amount equal to approximately 1 to 20
weight percent MSM relative to the weight of the entire skin
lightening composition. Liquid solutions for topical application
may include MSM in aqueous or non-aqueous solutions or emulsions.
It is contemplated that the skin lightening composition may be
combined with other cosmetics, such as moisturizers or perfumes, in
order to provide a skin lightening composition with properties in
addition to its skin lightening properties. By way of example, the
skin whitening formula may comprises a moisturizing face and body
cream into which the MSM has been blended. It is additionally
contemplated that the skin lightening composition will be provided
as a solid mixture, e.g. a mixture of MSM with vitamins and
minerals that a user can mix with water and use for washing the
face and body. Alternately, the skin whitening formula may be
supplied as a liquid solution which may be directly used as a face
and body wash.
[0018] Orally ingestible preparations of the skin lightening
composition are provided in liquid or in solid form, and contain
approximately 200 mg to 5000 mg MSM per serving. Orally ingestible
preparations of the skin whitening formula may be in an edible form
such as a tablet, a pill, a capsule, or in powder form. MSM can
also be orally ingested in a nutritious mixture that contains
vitamins, minerals, herbs, antioxidants, proteins, and/or amino
acids.
[0019] In conclusion, herein is presented a skin lightening
composition for lightening the natural skin color of a user, and
also for treating disorders of hyperpigmentation. The invention is
illustrated by example throughout the written description. It
should be understood that numerous variations are possible, while
adhering to the inventive concept. Such variations are contemplated
as being a part of the present invention.
* * * * *