U.S. patent application number 10/949367 was filed with the patent office on 2005-06-30 for compositions for treating and/or preventing pollinosis.
This patent application is currently assigned to Hououdou Co., Ltd.. Invention is credited to Tsuchida, Kenjirou, Tsuchida, Kotarou, Tsuchida, Yuuzou.
Application Number | 20050142233 10/949367 |
Document ID | / |
Family ID | 34702711 |
Filed Date | 2005-06-30 |
United States Patent
Application |
20050142233 |
Kind Code |
A1 |
Tsuchida, Yuuzou ; et
al. |
June 30, 2005 |
Compositions for treating and/or preventing pollinosis
Abstract
The present invention provides a composition for treating and/or
preventing pollinosis which comprises an extract from Sasa
albo-marginata in an amount ranging from 1 to 10% by mass as
expressed in terms of the solid content of the extract. The
composition of the present invention comprises a Sasa
albo-marginata extract in a concentration considerably higher than
that conventionally used and accordingly, it shows a high effect of
treating and/or preventing various symptoms associated with serious
pollinosis, which has been quite difficult to treat and/or prevent
with the conventional anti-histamic agents or steroidal drugs,
without accompanying any side-effect.
Inventors: |
Tsuchida, Yuuzou; (Tokyo,
JP) ; Tsuchida, Kotarou; (Tokyo, JP) ;
Tsuchida, Kenjirou; (Tokyo, JP) |
Correspondence
Address: |
OBLON, SPIVAK, MCCLELLAND, MAIER & NEUSTADT, P.C.
1940 DUKE STREET
ALEXANDRIA
VA
22314
US
|
Assignee: |
Hououdou Co., Ltd.
Tokyo
JP
|
Family ID: |
34702711 |
Appl. No.: |
10/949367 |
Filed: |
September 27, 2004 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
|
|
10949367 |
Sep 27, 2004 |
|
|
|
PCT/JP03/03822 |
Mar 27, 2003 |
|
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Current U.S.
Class: |
424/769 |
Current CPC
Class: |
A61K 36/899
20130101 |
Class at
Publication: |
424/769 |
International
Class: |
A61K 035/78 |
Foreign Application Data
Date |
Code |
Application Number |
Mar 27, 2002 |
JP |
2002-88823 |
Claims
1. A composition for treating and/or preventing pollinosis
comprising an extract from Sasa albo-marginata in an amount ranging
from 1 to 10% by mass as expressed in terms of the solid content of
the extract.
2. The composition for treating and/or preventing pollinosis of
claim 1, wherein it comprises sulfur-containing components derived
from the Sasa albo-marginata extract in an amount ranging from 4 to
100 mg per 100 g of the composition as expressed in terms of the
amount of sulfur.
3. The composition for treating and/or preventing pollinosis of
claim 1, wherein the content of the Sasa albo-marginata extract
ranges from 2 to 8% by mass as expressed in terms of the amount of
the solid contents.
4. The composition for treating and/or preventing pollinosis as set
forth in claim 1, wherein it is in the form of a cream
composition.
5. The composition for treating and/or preventing pollinosis as set
forth in claim 1, wherein it further comprises an organic acid.
6. The composition for treating and/or preventing pollinosis as set
forth in claim 1, wherein it further comprises tannin derived from
Sasa albo-marginata.
Description
TECHNICAL FIELD
[0001] The present invention relates to a composition for treating
and/or preventing pollinosis, which comprises an extract from Sasa
albo-marginata (Bambooseae Sasa) as an effective component.
BACKGROUND ART
[0002] Recently, there have rapidly been increased the number of
patients suffering from allergic symptoms (hereunder referred to as
"pollinosis") accompanied by, for instance, conjunctivitis (itching
and congestion of eyes), rhinitis (sneezing, snivel and nasal
congestion) and bronchial asthma, which are caused due to the
allergic hypersensitivity against pollens of, for instance, hinoki
(white cedar), sugi (Japanese cedar) and ragweed (Ambrosia
artemisiifolia), and dead bodies of, for instance, ticks or mites.
In respect of pollinosis, a steroidal drug has been used for
alleviating the related symptoms, but the symptoms have never been
alleviated in a large number of patients even if such a steroidal
drug is administered to these patients. Accordingly, there has been
desired for the development of an effective means for treating
and/or alleviating pollinosis.
DISCLOSURE OF THE INVENTION
[0003] It is thus an object of the present invention to provide a
composition for treating and/or preventing pollinosis, which can
ensure a high effect of treating and/or preventing pollinosis.
[0004] According to the present invention, there is provided a
composition for treating and/or preventing pollinosis, which
comprises an extract from Sasa albo-marginata (Bambooseae Sasa) in
an amount ranging from 1 to 10% by mass as expressed in terms of
the solid content of the extract.
[0005] The term "pollinosis" as used herein means the allergic
symptoms (pollinosis in a broad sense), which are caused due to the
allergic hypersensitivity against pollens of, for instance, hinoki
(white cedar), sugi (Japanese cedar) and ragweed (Ambrosia
artemisiifolia), and dead bodies of, for instance, ticks or mites
and which are accompanied by, for instance, conjunctivitis (itching
and congestion of eyes), rhinitis (sneezing, snivel and nasal
congestion) and bronchial asthma, and more specifically, the term
means the allergosis (pollinosis in a narrow sense), which are
caused due to the allergic hypersensitivity against pollens and
accompanied by, for instance, conjunctivitis (itching and
congestion of eyes), rhinitis (sneezing, snivel and nasal
congestion) and bronchial asthma.
BEST MODE FOR CARRYING OUT THE INVENTION
[0006] The present invention relates to a composition for treating
and/or preventing pollinosis, which comprises an extract from Sasa
albo-marginata in an amount ranging from 1 to 10% by mass,
preferably 2 to 8% by mass and more preferably 3 to 6% by mass, as
expressed in terms of the solid content of the extract. In this
respect, if the content of the extract from Sasa albo-marginata is
less than 1% by mass, the resulting composition is insufficient in
the intended effect of treating and/or preventing the pollinosis,
while if the content thereof exceeds 10% by mass, the composition
would be too stimulative to the skin.
[0007] Conventionally, the Sasa albo-marginata extract has been
prepared in the form of an extract having a solid content ranging
from 0.5 to 10% by mass and has been used in a variety of
applications. The extract having such a solid content has been used
in such a manner that the content thereof in a final product in
general ranges from about 1 to 10% by mass and therefore, the solid
content of the Sasa albo-marginata extract in the final product in
general ranges from about 0.05 to 0.8% by mass and at highest on
the order of less than 1% by mass. The reason for this is, for
instance, that the Sasa albo-marginata extract is relatively
expensive, that the extract would show the anti-inflammatory effect
and antibiotic action even in such a low concentration to some
extent and that it would be unreasonable to increase the added
amount of the effective component to a level of not less than 10%
by mass. However, the product having such a low content of the
extract is almost ineffective in the treatment and/or prevention of
pollinosis.
[0008] The inventors of this invention have found that if the Sasa
albo-marginata extract is present in a final product in a solid
content ranging from 1 to 10% by mass, preferably 2 to 8% by mass
and more preferably 3 to 6% by mass, the product shows a highly
improved effect of treating and/or preventing pollinosis, which
have never been recognized when using a conventional extract having
a low solid content. Thus, the inventors of this invention have
completed the present invention on the basis of these findings.
[0009] The Sasa albo-marginata extract per se has long been known,
but there has never been tried any attempt to use an extract in
such a high solid content. The reason for this has not yet been
elucidated, but it has surprisingly been recognized that the use of
such an extract in a concentration higher than that of the
conventionally used one (not less than 10 times) would permit the
significant improvement of the effect of treating and/or preventing
pollinosis.
[0010] The Sasa albo-marginata used in the present invention, as a
raw material for the extract thereof is not restricted to any
specific one and any plant belonging to the genus Sasa may be used
herein. Specific examples thereof include those specified below:
Kumai Sasa; Sasa albo-marginata Makino et Shibata (Kuma Sasa);
ground bamboo; Okuyama Sasa; Ezo-Miyama Sasa; Sasa Paniculata
Makino et Shibata; Yahiko Sasa; Oba Sasa; Miyama Sasa; Sendai Sasa;
Yukawa Sasa; Aboi Sasa; and Onuka Sasa. Among these, specific
examples of commercially available ones include Kumai Sasa and Kuma
Sasa (Chugoku Sasa and Hida Sasa). For instance, preferably used
herein are extracts derived from, for instance, Kumai Sasa and/or
Kuma Sasa collected in, for instance, TESHIO Mountains in Hokkaido
during the term extending from July to October.
[0011] The Sasa albo-marginata extract used in the present
invention is preferably one prepared by extracting raw leaves or
dried leaves of Sasa albo-marginata, preferably dried leaves
thereof with water maintained at. a temperature ranging from 100 to
180.degree. C. at ordinary pressure or while applying a
pressure.
[0012] The extraction method is not restricted to any particular
one, but usable herein includes, for instance, that disclosed in
Japanese Patent No. 3,212,278 (Japanese Un-Examined Patent
Publication Hei 11-196818). More specifically, leaves of Sasa
albo-marginata are extracted at a temperature ranging from 100 to
180.degree. C. for 5 to 30 minutes using a pressurized hot water
extraction device, the resulting extract is separated into a
moisture-containing solid content (moisture content: 40 to 70%) in
a moisture separator, thereafter the moisture-containing solid
content is treated at a temperature ranging from 100 to 200.degree.
C. for 5 to 60 minutes in a saturated vapor-heating device, the
solid content thus treated is again treated at 100 to 180.degree.
C. for 5 to 30 minutes using a pressurized hot water extraction
device and the extracts obtained in the first and second extraction
steps are combined prior to practical use. Alternatively, it is
also possible to use an extract obtained by extracting dried leaves
of Sasa albo-marginata with, for instance, water heated to 60 to
100.degree. C. for 30 minutes to 12 hours.
[0013] There has been known "AHSS" available from
CHLOROLAND.MOSHIRI CO.,LTD as an example of commercially available
one having a content of the Sasa albo-marginata extract of 50% by
mass as expressed in terms of the solid content of the extract.
[0014] The Sasa albo-marginata extract thus obtained contains
sulfur-containing components and the content thereof as expressed
in terms of the amount of sulfur ranges from about 4 to 10 mg and
usually about 6 to 9 mg per one gram of the solid content of the
Sasa albo-marginata extract. Principal constituents of the
sulfur-containing components are considered to be sulfur-containing
amino acids.
[0015] The composition for treating and/or preventing pollinosis
according to the present invention comprises such sulfur-containing
components derived from the Sasa albo-marginata extract in an
amount preferably ranging from 4 to 500 mg, more preferably 8 to
250 mg and most preferably 16 to 150 mg per 100 g of the
composition, as expressed in terms of the amount of sulfur.
[0016] Moreover, the solid content of the Sasa albo-marginata
extract contains tannin and the content thereof in the solid
contents is in the order of about 5 to 15% by mass based on the
mass of the solid contents present in the extract.
[0017] It is desirable that the composition for treating and/or
preventing pollinosis according to the present invention comprise
the tannin derived from the Sasa albo-marginata extract in an
amount preferably ranging from 0.05 to 7.5% by mass and more
preferably 0.1 to 6% by mass as expressed in terms of the
concentration of the solid contents thereof.
[0018] The composition for treating and/or preventing pollinosis
according to the present invention may comprise only the Sasa
albo-marginata extract as an effective component or the
simultaneous use of a reasonable amount of an organic acid would
permit the further improvement of the resulting composition in its
effect of treating and/or preventing pollinosis. Examples of such
organic acids include malic acid, citric acid, lactic acid, oxalic
acid, malonic acid, succinic acid, fumaric acid, acetic acid,
benzoic acid, phenyl-acetic acid, salicylic acid and phenols.
[0019] The amount of such an organic acid used in the composition
for treating and/or preventing pollinosis according to the present
invention preferably ranges from 0.01 to 5% by mass, more
preferably 0.02 to 3% by mass and most preferably 0.05 to 1.5% by
mass based on the total mass of the composition.
[0020] In the preparation of the composition for treating and/or
preventing pollinosis according to the present invention, there may
be used, for instance, a basic component such as an oily component,
a moisture retentive agent and/or a preservative (or an
antiseptic), which are commonly used in pharmaceutical
compositions, cosmetics and compositions applied to the skin, in
addition to a desired amount of the foregoing Sasa albo-marginata
extract.
[0021] The origins of the water used in the composition are not
restricted to particular ones and examples thereof include tap
water, natural water and purified water, but preferably used herein
is highly purified water such as ion-exchange water.
[0022] Examples of oily components usable herein are oils derived
from animals such as squalane, tallow, lard, horse fat, lanolin and
beeswax; oils derived from vegetables such as olive oil, grape seed
oil, palm oil, jojoba oil and germ oil (such as rice germ oil); and
synthetic or semi-synthetic oils such as liquid paraifin, higher
fatty acid esters (such as octyl palmitate, isopropyl palmitate and
octyl dodecyl myristate) and silicone oil.
[0023] The oily components are used in appropriate combinations
depending on the performance requirement, for instance, an ability
of protecting the skin, an effect of imparting emollient (or an
effect of preventing drying of the skin and imparting softness and
resilience to the skin through the coverage of the skin surface
with a thin film) and an ability of imparting refreshed feeling to
the skin. In one of preferred examples of such combinations, the
oily component comprises squalane, olive oil and octyl dodecyl
myristate.
[0024] The composition comprises a solid oil component such as
stearic acid, stearyl alcohol, behenic acid, cetanol and vaseline
to control the hardness and flowability of the composition and the
composition preferably comprises stearic acid and cetanol in
combination.
[0025] When preparing the composition for treating and/or
preventing pollinosis according to the present invention in the
form of a cream composition, a creaming agent is used to convert
the mixture of the Sasa albo-marginata extract, water and an oily
component into a cream. Such a creaming agent is not restricted to
any particular one, but glycerin monostearate and a
self-emulsifiable glycerin monostearate (a product obtained by
incorporating an emulsifying agent into glycerin monostearate) are
in general used in combination.
[0026] Moreover, the composition for treating and/or preventing
pollinosis according to the present invention may, if necessary,
contain other additives such as a stabilizer, a moisture retentive
agent, a wound-healing agent, a preservative and/or a
surfactant.
[0027] Examples of stabilizers are a combination of a carboxy vinyl
polymer with potassium hydroxide, and polyethylene glycol
distearate. In particular, polyethylene glycol sesquistearate (a
1:1 mixture of polyethylene glycol distearate and polyethylene
glycol monostearate) (molecular weight of the polyethylene glycol
ranging from 1000 to 20,000) is preferably used herein since it has
high stability, it is never separated into water and oil and the
hardness required when the composition is applied to the skin in
the form of a cream composition can effectively be controlled.
[0028] Examples of moisture retentive agents usable herein are
sodium salt of hyaluronic acid, collagen, aloe extract (in
particular, aloe extract (2) derived from Aloe arborescens is
preferred), urea, 1,3-butylene glycol, glycerin, trehalose,
sorbitol, amino acids and sodium salt of pyrrolidone carboxylic
acid.
[0029] Examples of wound-healing agents usable herein are
allantoin, dipotassium glycyrrhizinate, glycyrrhiza extract and
mugwort extract.
[0030] The preservative (or antiseptic) is used subsidiarily since
the Sasa albo-marginata extract has an antibiotic effect by nature.
Examples of such preservatives are sodium benzoate, lower alkyl
esters of p-hydroxy benzoic acid (for instance, so-called paraben
such as methyl, ethyl, propyl or butyl ester), sodium propionate,
mixed fatty acid esters (a mixture of capric acid glyceryl, lauric
acid polyglyceryl-2 and lauric acid polyglyceryl- 10), phenoxytal,
and light-sensitive substance No. 201 (yellow dye), with paraben
and mixed fatty acid esters being preferably used herein.
[0031] Examples of surfactants are sodium N-acyl-L-glutamate and
polyoxyethylene sorbitan monostearate.
[0032] In addition, the composition may, if required, comprise
aroma components such as orange oil, lemon oil, bitter orange peel
oil and perfumes.
[0033] Water and, if necessary, an organic acid are added to the
foregoing components to make the total amount of the resulting
composition 100% by mass.
[0034] The following Table 1 shows preferred amounts (% by mass) of
the foregoing ingredients required for preparing the composition
for treating and/or preventing pollinosis according to the
invention in the form of a cream composition. The amount of each
component other than water corresponds to the mass thereof free of
any moisture.
1TABLE 1 More Most Preferred preferred preferred Component range
range range Sasa albo-marginata 1 to 10 2 to 8 3 to 6 extract
Liquid oily component 6 to 30 2 to 20 5 to 15 Solid oily component
2 to 35 3 to 25 5 to 15 Creaming agent 1 to 6 1.5 to 4 1.6 to 3
Stabilizer 0 to 2 0 to 1.5 0 to 1 Moisture retentive agent 0 to 10
0.05 to 5 0.1 to 5 Wound-healing agent 0 to 2 0.05 to 1 0.1 to 0.5
Aroma component 0 to 5 0 to 3 0 to 1 Organic acid 0.01 to 5 0.1 to
3 0.5 to 1.5 Water Balance Balance Balance
[0035] The foregoing components are introduced into a
heating-mixing kettle equipped with a stirring blade and preferably
an emulsification apparatus and they are then admixed together at
70 to 90.degree. C. for one to two hours to form a composition for
treating and/or preventing pollinosis according to the
invention.
[0036] The composition for treating and/or preventing pollinosis
according to the invention may be used in various dosage forms
other than a cream composition such as an ointment, a liquid, a
jelly, an eye drop and other forms, with a cream composition being
preferred because it can easily be used and shows a considerable
effect.
[0037] Alternatively, the composition of the present invention may
likewise be used in the form of a mask obtained by impregnating a
substrate such as absorbent gauze with the Sasa albo-marginata
extract at a high temperature of preferably not less than
80.degree. C. in an amount ranging from 1 to 10% by mass as
expressed in terms of the solid content of the extract and then
drying the impregnated substrate and the resulting mask is also
effectively used for treating and/or preventing pollinosis.
[0038] It is sufficient to apply the composition of the present
invention to the affected part, after cleaning the same, in an
appropriate amount thereof, for instance, 0.1 to 1 g per 100
cm.sup.2 of the skin in case of a cream composition over 1 to 5
times, usually 1 to 3 times a day.
[0039] In case of, for instance, the itching of eyes, it is
likewise sufficient to apply a cream composition to the eyelids, in
particular, the periphery thereof and/or the lower eyelid of a
patient. It is also possible to apply an eye drop to the eyes of a
patient. Such an eye drop may desirably comprise 2 to 8% by mass
and preferably 2 to 3% by mass of the Sasa albo-marginata extract
as expressed in terms of the solid content thereof. The amount and
number of application of the composition or the number of dropping
thereof in the eyes may appropriately be changed while taking into
consideration, for instance, the extent of pollinosis. When
applying the composition for treating and/or preventing pollinosis
according to the invention to the affected part, the typical
symptoms of pollinosis (such as itching and congestion of eyes,
sneezing, snivel and nasal congestion) would rapidly be alleviated
or eliminated within the term generally ranging from about 5 to 10
minutes.
[0040] The composition of the present invention comprises 1 to 10%
by mass of the Sasa albo-marginata extract as expressed in terms of
the solid content and accordingly, the composition would show a
considerable effect of improving various symptoms associated with
the pollinosis.
[0041] The following are preferred embodiments of the composition
for treating and/or preventing pollinosis according to the present
invention.
[0042] 1. A composition for treating and/or preventing pollinosis,
which comprises the Sasa albo-marginata extract (1 to 10% by mass
as expressed in terms of the solid content), water, an oily
component and a creaming agent.
[0043] 2. The composition according to the foregoing item 1 in
which the oily component is at least one member selected from the
group consisting of animal oil, vegetable oil, synthetic oil and
semi-synthetic oil.
[0044] 3. The composition according to the foregoing item 1 in
which the oily component is at least one member selected from the
group consisting of squalane, tallow, lard, horse fat, lanolin,
beeswax, olive oil, grape seed oil, palm oil, jojoba oil, germ oil,
liquid paraffin, octyl palmitate, isopropyl palmitate, octyl
dodecyl myristate, silicone oil, stearic acid, stearyl alcohol,
behenic acid, cetanol and vaseline.
[0045] 4. The composition according to any one of the foregoing
items 1 to 3 in which the creaming agent is a combination of
glycerin monostearate with self-emulsifiable glycerin
monostearate.
[0046] 5. The composition according to any one of the foregoing
items 1 to 4 which further comprises at least one component
selected from the group consisting of a stabilizer, a moisture
retentive agent, a wound-healing agent, a preservative and a
surfactant.
[0047] 6. The composition according to the foregoing item 5 in
which the stabilizer is at least one member selected from the group
consisting of a combination of a carboxy vinyl polymer with
potassium hydroxide, and polyethylene glycol distearate.
[0048] 7. The composition according to the foregoing item 5 in
which the moisture retentive agent is at least one member selected
from the group consisting of sodium salt of hyaluronic acid,
collagen, aloe extract, urea, 1,3-butylene glycol, glycerin,
trehalose, sorbitol, amino acids and sodium salt of pyrrolidone
carboxylic acid.
[0049] 8. The composition according to the foregoing item 5 in
which the wound-healing agent is at least one member selected from
the group consisting of allantoin, dipotassium glycyrrhizinate,
glycyrrhiza extract and mugwort extract.
[0050] 9. The composition according to the foregoing item 5 in
which the preservative is at least one member selected from the
group consisting of sodium benzoate, lower alkyl esters of
p-hydroxy benzoic acid, sodium propionate, mixed fatty acid esters,
phenoxytal, and yellow dye.
[0051] 10. The composition according to the foregoing item 5 which
further comprises at least one member selected from the group
consisting of orange oil, lemon oil, bitter orange peel oil and
perfumes.
[0052] 11. The composition according to the foregoing item 10,
which comprises a Sasa albo-marginata extract, water, an oily
component, a creaming agent, a stabilizer, a moisture retentive
agent, a wound-healing-promoting agent, a preservative and a
surfactant, wherein the oily component is at least one member
selected from the group consisting of squalane, tallow, lard, horse
fat, lanolin, beeswax, olive oil, grape seed oil, palm oil, jojoba
oil, germ oil, liquid paraffin, octyl palmitate, isopropyl
palmitate, octyl dodecyl myristate, silicone oil, stearic acid,
stearyl alcohol, behenic acid, cetanol and vaseline; the creaming
agent is a combination of glycerin monostearate with
self-emulsifiable glycerin monostearate; the stabilizer is at least
one member selected from the group consisting of a combination of a
carboxy vinyl polymer with potassium hydroxide and polyethylene
glycol distearate; the moisture retentive agent is at least one
member selected from the group consisting of sodium salt of
hyaluronic acid, collagen, aloe extract, urea, 1,3-butylene glycol,
glycerin, trehalose, sorbitol, amino acids and sodium salt of
pyrrolidone carboxylic acid; the wound-healing agent is at least
one member selected from the group consisting of allantoin,
dipotassium glycyrrhizinate, glycyrrhiza extract and mugwort
extract; the preservative is at least one member selected from the
group consisting of sodium benzoate, lower alkyl esters of
p-hydroxy benzoic acid, sodium propionate, mixed fatty acid esters,
phenoxytal, and yellow dye; and the surfactant is sodium
N-acyl-L-glutamate.
[0053] 12. The composition as set forth in the foregoing item 11
which further comprises at least one member selected from the group
consisting of orange oil, lemon oil, bitter orange peel oil and
perfumes.
[0054] 13. The composition as set forth in the foregoing item 1
which comprises a Sasa albo-marginata extract, water, squalane,
olive oil, glycerin monostearate, self-emulsifiable glycerin
monostearate, a carboxy vinyl polymer, potassium hydroxide, urea,
1,3-butylene glycol, allantoin, a lower alkyl ester of p-hydroxy
benzoic acid, stearic acid, sodium N-acyl-L-glutamate and lemon
oil.
[0055] 14. The composition as set forth in the foregoing item 1
which comprises a Sasa albo-marginata extract, water, squalane,
olive oil, octyl dodecyl myristate, cetanol, glycerin monostearate,
self-emulsifiable glycerin monostearate, a carboxy vinyl polymer,
potassium hydroxide, urea, 1,3-butylene glycol, allantoin, a mixed
fatty acid ester, stearic acid, sodium N-acyl-L-glutamate and
orange oil.
[0056] 15. The composition as set forth in any one of the foregoing
items 1 to 14 which comprises polyethylene glycol
sesquistearate.
[0057] 16. A composition for treating and/or preventing pollinosis
which comprises an aqueous solution containing a Sasa
albo-marginata extract (1 to 10% by mass as expressed in terms of
the solid content).
[0058] 17. The composition of the foregoing item 16 in which it is
in the form of an eye drop or a mouthwash.
[0059] The present invention will hereunder be described in more
detail with reference to the following Reference Examples, working
Examples and Test Examples.
REFERENCE EXAMPLE 1
Preparation of Sasa albo-marginata Extract
[0060] Dried leaves of the Sasa albo-marginata collected in TESHIO
Mountains in Hokkaido Japan in September were introduced into a
pressurized hot water extraction tank, treated at 125.degree. C.
for 10 minutes in the tank, the hot water was cooled down to about
80.degree. C. by the action of a cooling water and then the
resulting extract was separated from the moisture-containing solid
content using a screw-press in such a manner that the moisture
content of the latter was controlled to a level of about 50% by
mass. Then the solid contents having a moisture content of about
50% by mass were introduced into an autoclave and heat-treated
under pressure at 180.degree. C. for 10 minutes using saturated
steam. The moisture-containing solid contents thus treated were
again introduced into a pressurized hot water-extraction tank and
treated at 110.degree. C. for 5 minutes to thus obtain an extract.
The first and second extracts were combined together, filtered
through a diatomaceous earth layer, the resulting filtrate was
concentrated under reduced pressure till the solid content thereof
was increased to 50% by mass and the concentrate thus prepared was
subjected to a fluidized sterilization treatment at a temperature
ranging from 110 to 130.degree. C. to give a Sasa albo-marginata
extract.
[0061] The Sasa albo-marginata extract was inspected for the sulfur
content and it was found to be 3850 .mu.m/ml (7.7 mg per one gram
of the solid content).
REFERENCE EXAMPLE 2
[0062] The commercially available Sasa albo-marginata extract (the
extract derived from Bambuseae Sasa; available from HOUOUDOU Co.,
Ltd.) was inspected for the components thereof and as a result, the
extract included the following components: Water: 59.5% by mass;
Proteins: 8.6% by mass; Lipid: 0.6% by mass; Minerals: 9.0% by
mass; Carbohydrates: 19.8% by mass; and Tannin: 2.5% by mass.
EXAMPLES 1 to 4
[0063] The components listed in the following Table 2 were admixed
together in amounts (% by mass) likewise specified in Table 2,
introduced into a heating and mixing kettle equipped with a
stirring blade and an emulsification apparatus and then mixed
therein with stirring at 80.degree. C. for 2 hours to thus give a
cream composition for treating and/or preventing pollinosis
according to the present invention. The added amounts of a Sasa
albo-marginata extract having a solid content of 8% by mass (a
product obtained by diluting the Sasa albo-marginata extract having
a solid content of 50% by mass and prepared in Reference Example 1)
were 12.5, 25, 37.5 and 75% by mass respectively (therefore, the
contents of the extract as expressed in terms of the solid content
thereof were 1, 2, 3 and 6% by mass; and sulfur contents of these
samples were 7.7 mg, 15.4 mg, 23.1 mg and 46.2 mg per 100 g of the
composition, respectively).
2TABLE 2 Component Amount (% by mass) Squalane 5.0 Olive oil 6.0
Lemon oil 1.0 Stearic acid 4.0 Glycerin monostearate 0.8 Carboxy
vinyl polymer (CARBOPOL 940) 0.2 Glycerin monostearate
(self-emulsifiable type) 1.0 Sodium N-acyl-L-glutamate 0.2
1,3-Butylene glycol 1.0 Urea 10.0 Allantoin 0.1 Methyl
p-oxy-benzoate 0.1 Propyl p-oxy-benzoate 0.1 Sasa albo-marginata
extract (solid content 8% by Desired amount mass) Potassium
hydroxide 0.02 Ion-exchange water Balance
EXAMPLE 5
[0064] The same procedures used in Examples 1 to 4 were repeated
using the components shown in the following Table 3 in the amounts
likewise specified in Table 3 to thus give each corresponding cream
composition for treating and/or preventing pollinosis according to
the present invention.
3TABLE 3 Component Amount (% by mass) Squalane 1.0 Olive oil 4.0
Orange oil 1.0 Octyl dodecyl myristate 5.0 Stearic acid 4.0 Cetanol
2.0 Polyethylene glycol di-stearate 0.5 Glycerin monostearate 1.0
Carboxy vinyl polymer (CARBOPOL 940) 0.2 Glycerin monostearate
(self-emulsifiable type) 1.4 Sodium N-acyl-L-glutamate 0.2
1,3-Butylene glycol 1.0 Urea 3.0 Allantoin 0.1 Mixed fatty acid
ester (NIKOGUARD DL) 0.5 Sasa albo-marginata extract (solid
content: 8% by 75.0 mass) Potassium hydroxide 0.05 Ion-exchange
water (ad. 100 ml) 0.05
[0065] The resulting composition was found to have a sulfur content
of 46.2 mg per 100 g thereof.
EXAMPLE 6
[0066] The components listed in the following Table 4 were admied
together in amounts (% by mass) likewise specified in Table 4,
introduced into a heating and mixing kettle equipped with a
stirring blade and an emulsification apparatus and then mixed
therein with stirring at 80.degree. C. for 2 hours to thus give a
cream composition for treating and/or preventing pollinosis
according to the present invention.
4TABLE 4 Component Amount (% by mass) Liquid paraffin 10.0 Squalane
1.0 Olive oil 1.0 Orange oil 1.0 Octyl dodecyl myristate 6.0
1,2-Pentanediol 0.5 Phenoxy-ethanol 0.5 Cetanol 1.5 Stearic acid
4.0 Glycerin monostearate 2.0 Glycerin monostearate
(self-emulsifiable type) 2.5 Polyethylene glycol di-stearate 0.5
Carboxy vinyl polymer 0.3 Sodium N-acyl-L-glutamate 0.2
1,3-Butylene glycol 1.0 Ethanol 3.0 Tri-methyl glycine 0.5 Sodium
hyaluronate 1.0 Sasa albo-marginata extract (solid content: 12.0
50% by mass) Purified water 51.5
[0067] The pH value of the resulting cream was found to be
6.00.
EXAMPLE 7
[0068] The components listed in the following Table 5 were admixed
together in amounts (% by mass) likewise specified in Table 5,
introduced into a heating and mixing kettle equipped with a
stirring blade and an emulsification apparatus and then mixed
therein with stirring at 80.degree. C. for 2 hours to thus give a
cream composition for treating and/or preventing pollinosis
according to the present invention.
5TABLE 5 Component Amount (% by mass) Olive oil 3.0 Squalane 1.0
Liquid paraffin 3.0 Cetanol 1.3 Glycerin monostearate 2.0 Glycerin
monostearate (self-emulsifiable type) 5.0 Polyoxyethylene (20)
stearyl ether 1.0 Polyoxyethylene (20) cetyl ether 1.0
Polyoxyethylene (140) monostearate 1.0 Bentonite 0.5 Xanthane gum
0.2 Glucono-.delta.-lactone 4.0 dl-Malic acid 1.0 Triethanolamine
3.3 1,2-Pentanediol 0.5 Phenoxy-ethanol 0.5 1,3-Butylene glycol 2.0
Sasa albo-marginata extract (solid content: 12.0 50% by mass)
Purified water 57.7
[0069] The pH value of the resulting cream was found to be
4.68.
EXAMPLES 8 to 10
[0070] The same procedures used in Example 7 were repeated except
that dl-malic acid was not added, that the amount of the Sasa
albo-marginata extract (solid content: 50% by mass) used was
changed to 16, 20 or 30% by mass and that the amount of the
purified water was correspondingly controlled to thus give each
corresponding cream for treating and/or preventing pollinosis
according to the present invention, which had a content of the Sasa
albo-marginata extract (amount of the solid content thereof) was 8,
10 or 15% by mass.
EXAMPLES 11 to 13
[0071] The same procedures used in Example 7 were repeated except
that the amount of the Sasa albo-marginata extract (solid content:
50% by mass) used was changed to 16, 20 or 30% by mass and that the
amount of the purified water was correspondingly controlled to thus
give each corresponding cream for treating and/or preventing
pollinosis according to the present invention, which had a content
of the Sasa albo-marginata extract (amount of the solid content
thereof) was 8, 10 or 15% by mass.
TEST EXAMPLE 1
Effect of Alleviating the Symptoms of Patients Suffering from
Pollinosis
[0072] When applying, to patients suffering from pollinosis, the
cream composition (having a content of the solid contents of the
Sasa albo-marginata extract equal to 2% by mass) for treating
and/or preventing pollinosis which was prepared in Example 2, there
were observed the results listed in the following Table 6. Table 6
also shows the symptoms of the patients (affected parts, extent of
the symptoms), the site to which the composition was applied and
the extent of effects achieve. The extent of the patients' symptom
was evaluated according to the following three stage criteria: A:
serious; B: medium; and C: mild.
6TABLE 6 Patient No.; Symptoms Sex (age) Eye Nose Throat Others
Effects 1; male (43) -- B -- -- Quick acting 2; male (43) A A -- --
Quick acting 3; female (28) A A -- -- Sparingly effective 4; male
(29) A A -- -- Effective 5; male (39) C -- -- -- Effective 6;
female (33) A A -- -- Effective only for 2 to 3 hours 7; male (31)
A A -- -- Effective 8; male (48) A A -- -- Effective 9; male (51) A
A -- -- Effective 10; male (58) B B -- -- Effective 11; female (12)
B B -- -- Effective 12; male (38) -- A -- -- Effective 13; female
(19) A A -- -- Effective 14; male (42) B B -- -- Slightly effective
15; male (51) A A -- -- Effective 16; male (29) A A -- -- Effective
17; male (48) A A -- -- Slightly effective 18; female (45) A A --
-- Effective 19; male (28) A A -- -- Effective 20; male (59) -- B
-- -- Effective 21; female (55) A A -- -- Effective 22; male (60) A
A -- -- Effective 23; male (38) B B -- -- Effective 24; female (29)
-- C -- -- Effective 25; female (60) -- B -- -- Effective 26;
female (45) A A -- -- Effective 27; male (20) -- B -- -- Effective
28; female (62) A A -- -- Effective (simultaneously using an
anti-histamic agent) 29; female (45) A A -- -- Significantly
effective 30; female (45) -- B -- -- Effective (simultaneously
using an anti-histamic agent) 31; male (35) -- B -- -- Effective
32; male (55) -- A -- -- Effective (simultaneously using an
anti-histamic agent) 33; male (39) -- B -- -- Effective 34; female
(31) -- B -- -- Effective 35; female (46) A A B* -- Effective
(simultaneously using an anti-histamic agent) 36; male (50) -- B --
-- Effective 37; male (47) -- B -- -- Effective 38; female (22) --
B -- -- Effective 39; female (64) -- A -- -- Significantly
effective 40; female (27) -- B -- -- Quick acting 41; male (20) --
A -- -- Effective 42; male (42) -- A -- -- Effective *The patient
rinsed out her mouth with an aqueous solution containing the Sasa
albo-marginata extract in an amount of 2% by mass as expressed in
terms of the solid content.
[0073] The data listed in Table 6 clearly indicate that the
composition of the present invention has an effect of alleviating
the symptoms of a large number of patients suffering from
pollinosis. The composition of the invention may be used in
combination with an anti-histamic agent and in such case, the
composition would permit the reduction of the amount of the
anti-histamic agent to be used.
[0074] Industrial Applicability
[0075] The composition for treating and/or preventing pollinosis
according to the present invention, which comprises a Sasa
albo-marginata extract in an amount ranging from 1 to 10% by mass
as expressed in terms of the solid content, can show, in a clinical
level, a quite significant effect of treating and/or preventing
pollinosis for which there has not yet been proposed any effective
pollinosis-treating and/or preventing composition and it is
excellent in that it has no side-effect. More specifically, the
composition of the present invention shows a quite significant
effect of treating and/or preventing the allergic symptoms
(pollinosis in a broad sense), which are caused due to the allergic
hypersensitivity against pollens of, for instance, hinoki (white
cedar), sugi (Japanese cedar) and ragweed (Ambrosia
artemisiifolia), and dead bodies of, for instance, ticks or mites
and which are accompanied by, for instance, conjunctivitis (itching
and congestion of eyes), rhinitis (sneezing, snivel and nasal
congestion) and bronchial asthma, and in particular, the allergosis
(pollinosis in a narrow sense), which are caused due to the
allergic hypersensitivity against pollens and accompanied by, for
instance, conjunctivitis (itching and congestion of eyes), rhinitis
(sneezing, snivel and nasal congestion) and bronchial asthma,
without any side-effect.
* * * * *