U.S. patent application number 10/867147 was filed with the patent office on 2005-06-23 for gaba b receptors. Invention is credited to Mezler, Mario, Muller, Thomas, Raming, Klaus.
Application Number | 20050136511 10/867147 |
Document ID | / |
Family ID | 7929418 |
Filed Date | 2005-06-23 |
United States Patent Application | 20050136511 |
Kind Code | A1 |
Raming, Klaus ; et al. | June 23, 2005 |
The invention relates to polypeptides which exert the biological activity of GABA B receptors, and to nucleic acids which encode these polypeptides, and in particular to their use for finding active compounds for crop protection.
Inventors: | Raming, Klaus; (Leverkusen, DE) ; Mezler, Mario; (Leverkusen, DE) ; Muller, Thomas; (Bonn, DE) |
Correspondence Address: |
BAYER CROPSCIENCE LP Patent Department 100 BAYER ROAD PITTSBURGH PA 15205-9741 US |
Family ID: | 7929418 |
Appl. No.: | 10/867147 |
Filed: | June 14, 2004 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
10867147 | Jun 14, 2004 | |||
09715962 | Nov 17, 2000 | |||
6794149 | ||||
Current U.S. Class: | 435/69.1 ; 435/320.1; 435/325; 530/350; 536/23.5 |
Current CPC Class: | A01K 2217/05 20130101; C07K 14/70571 20130101 |
Class at Publication: | 435/069.1 ; 536/023.5; 530/350; 435/320.1; 435/325 |
International Class: | C07K 014/705; C07H 021/04 |
Date | Code | Application Number |
---|---|---|
Nov 18, 1999 | DE | 19955408.0 |
Sequence CWU 1
1
6 1 2523 DNA Drosophila melanogaster CDS (1)..(2520) 1 atg cgc aaa
gat atg aca agt gat ggt gct gtt acg ttt tgg ata ttt 48 Met Arg Lys
Asp Met Thr Ser Asp Gly Ala Val Thr Phe Trp Ile Phe 1 5 10 15 ttg
ctt tgt tta atc gcc tcg ccg cac ctg caa ggg ggc gtg gcc ggg 96 Leu
Leu Cys Leu Ile Ala Ser Pro His Leu Gln Gly Gly Val Ala Gly 20 25
30 agg ccc gat gaa ctg cac atc ggc ggc atc ttt ccg ata gcc ggc aaa
144 Arg Pro Asp Glu Leu His Ile Gly Gly Ile Phe Pro Ile Ala Gly Lys
35 40 45 gga gga tgg cag ggc ggc cag gcg tgt atg cct gcc aca aga
ctg gcg 192 Gly Gly Trp Gln Gly Gly Gln Ala Cys Met Pro Ala Thr Arg
Leu Ala 50 55 60 ttg gat gat gtc aac aag cag ccg aat ctg ctg ccg
ggc ttc aag ctc 240 Leu Asp Asp Val Asn Lys Gln Pro Asn Leu Leu Pro
Gly Phe Lys Leu 65 70 75 80 atc ctg cac agc aac gac agc gag tgt gag
ccc ggt ttg ggc gcc agc 288 Ile Leu His Ser Asn Asp Ser Glu Cys Glu
Pro Gly Leu Gly Ala Ser 85 90 95 gtg atg tac aat ctg ctc tat aat
aaa ccg caa aag ctg atg ctg ttg 336 Val Met Tyr Asn Leu Leu Tyr Asn
Lys Pro Gln Lys Leu Met Leu Leu 100 105 110 gca gga tgc agc acg gtc
tgc acc act gta gcc gag gct gcc aaa atg 384 Ala Gly Cys Ser Thr Val
Cys Thr Thr Val Ala Glu Ala Ala Lys Met 115 120 125 tgg aat cta att
gtg ctc tgc tac ggg gcc tcg agt ccg gct ctt tcg 432 Trp Asn Leu Ile
Val Leu Cys Tyr Gly Ala Ser Ser Pro Ala Leu Ser 130 135 140 gat cgc
aaa cga ttc ccc act cta ttc cgc acc cat cca tcg gcc acg 480 Asp Arg
Lys Arg Phe Pro Thr Leu Phe Arg Thr His Pro Ser Ala Thr 145 150 155
160 gtg cac aat cca acg cgc atc aag ctg atg aag aaa ttc ggc tgg tcc
528 Val His Asn Pro Thr Arg Ile Lys Leu Met Lys Lys Phe Gly Trp Ser
165 170 175 cgg gtg gcc att ctg cag cag gcg gag gag gtc ttt ata tcg
acc gta 576 Arg Val Ala Ile Leu Gln Gln Ala Glu Glu Val Phe Ile Ser
Thr Val 180 185 190 gag gat ctc gag aat cga tgc atg gag gct ggc gtt
gaa atc gta act 624 Glu Asp Leu Glu Asn Arg Cys Met Glu Ala Gly Val
Glu Ile Val Thr 195 200 205 aga caa tca ttt cta tcc gat cca aca gac
gcc gtg cgc aat ttg cga 672 Arg Gln Ser Phe Leu Ser Asp Pro Thr Asp
Ala Val Arg Asn Leu Arg 210 215 220 cgc cag gat gca cgc atc att gtg
gga ctc ttc tat gtg gtg gcc gcc 720 Arg Gln Asp Ala Arg Ile Ile Val
Gly Leu Phe Tyr Val Val Ala Ala 225 230 235 240 agg agg gtg ctc tgc
gaa atg tac aaa cag cag cta tat ggc cga gct 768 Arg Arg Val Leu Cys
Glu Met Tyr Lys Gln Gln Leu Tyr Gly Arg Ala 245 250 255 cat gtg tgg
ttc ttt att ggc tgg tac gag gac aac tgg tac gag gtg 816 His Val Trp
Phe Phe Ile Gly Trp Tyr Glu Asp Asn Trp Tyr Glu Val 260 265 270 aat
ctg aaa gca gag ggc atc acc tgc act gtt gaa cag atg cga ata 864 Asn
Leu Lys Ala Glu Gly Ile Thr Cys Thr Val Glu Gln Met Arg Ile 275 280
285 gct gcc gaa gga cat ctg aca acg gaa gcg ctc atg tgg aat cag aac
912 Ala Ala Glu Gly His Leu Thr Thr Glu Ala Leu Met Trp Asn Gln Asn
290 295 300 aat cag aca act ata tcc gga atg act gca gag gaa ttt cga
cat cga 960 Asn Gln Thr Thr Ile Ser Gly Met Thr Ala Glu Glu Phe Arg
His Arg 305 310 315 320 ctg aat cag gcg cta atc gag gag ggt tac gac
att aac cac gat cgc 1008 Leu Asn Gln Ala Leu Ile Glu Glu Gly Tyr
Asp Ile Asn His Asp Arg 325 330 335 tat ccg gag gga tat cag gag gcg
cca ctc gcc tac gat gca gtg tgg 1056 Tyr Pro Glu Gly Tyr Gln Glu
Ala Pro Leu Ala Tyr Asp Ala Val Trp 340 345 350 agt gtg gct ttg gct
ttc aac aag acc atg gaa cga ttg aca acc ggg 1104 Ser Val Ala Leu
Ala Phe Asn Lys Thr Met Glu Arg Leu Thr Thr Gly 355 360 365 aag aaa
tct ctg agg gat ttt acc tat acg gac aag gag att gcc gat 1152 Lys
Lys Ser Leu Arg Asp Phe Thr Tyr Thr Asp Lys Glu Ile Ala Asp 370 375
380 gaa atc tac gct gcc atg aac tcc aca caa ttt ctg ggt gta tcg ggt
1200 Glu Ile Tyr Ala Ala Met Asn Ser Thr Gln Phe Leu Gly Val Ser
Gly 385 390 395 400 gtg gtg gca ttc agt tct cag ggc gat cgt att gct
ctt aca cag atc 1248 Val Val Ala Phe Ser Ser Gln Gly Asp Arg Ile
Ala Leu Thr Gln Ile 405 410 415 gaa cag atg ata gac ggc aag tac gag
aag ttg ggt tac tac gat act 1296 Glu Gln Met Ile Asp Gly Lys Tyr
Glu Lys Leu Gly Tyr Tyr Asp Thr 420 425 430 cag ttg gat aac cta tcc
tgg ttg aat act gaa cag tgg att ggt ggc 1344 Gln Leu Asp Asn Leu
Ser Trp Leu Asn Thr Glu Gln Trp Ile Gly Gly 435 440 445 aag gtt cct
caa gat cgc aca att gtc acc cat gtt cta cgc acc gtg 1392 Lys Val
Pro Gln Asp Arg Thr Ile Val Thr His Val Leu Arg Thr Val 450 455 460
tcc ttg cca tta ttt gtg tgc atg tgc aca ata tcc agt tgt ggc ata
1440 Ser Leu Pro Leu Phe Val Cys Met Cys Thr Ile Ser Ser Cys Gly
Ile 465 470 475 480 ttc gtt gcc ttc gcc ttg atc atc ttt aat ata tgg
aat aag cat aga 1488 Phe Val Ala Phe Ala Leu Ile Ile Phe Asn Ile
Trp Asn Lys His Arg 485 490 495 aga gta ata caa tcc tcg cat ccc gtt
tgc aat acg atc atg tta ttt 1536 Arg Val Ile Gln Ser Ser His Pro
Val Cys Asn Thr Ile Met Leu Phe 500 505 510 ggt gtc atc atc tgt cta
ata tct gtc atc tta ctg ggc atc gac gga 1584 Gly Val Ile Ile Cys
Leu Ile Ser Val Ile Leu Leu Gly Ile Asp Gly 515 520 525 cgc ttt gtc
agc ccc gag gaa tat cca aag ata tgt caa gcg cgg gct 1632 Arg Phe
Val Ser Pro Glu Glu Tyr Pro Lys Ile Cys Gln Ala Arg Ala 530 535 540
tgg tta cta tcc acc ggt ttt aca cta gca tac ggt gct atg ttc agc
1680 Trp Leu Leu Ser Thr Gly Phe Thr Leu Ala Tyr Gly Ala Met Phe
Ser 545 550 555 560 aag gtc tgg cgt gtg cat cgt ttt aca aca aaa gca
aaa act gac cca 1728 Lys Val Trp Arg Val His Arg Phe Thr Thr Lys
Ala Lys Thr Asp Pro 565 570 575 aag aaa aaa gtg gaa cct tgg aag cta
tac acc atg gtt tcg ggg cta 1776 Lys Lys Lys Val Glu Pro Trp Lys
Leu Tyr Thr Met Val Ser Gly Leu 580 585 590 tta tca ata gat tta gtg
ata tta ctc tca tgg cag atc ttt gat ccg 1824 Leu Ser Ile Asp Leu
Val Ile Leu Leu Ser Trp Gln Ile Phe Asp Pro 595 600 605 ctg cag cgt
tat ctc gaa aca ttc cca ctc gaa gat cca gta tct act 1872 Leu Gln
Arg Tyr Leu Glu Thr Phe Pro Leu Glu Asp Pro Val Ser Thr 610 615 620
act gat gat att aaa ata cgt cca gag ctt gag cat tgt gaa agt caa
1920 Thr Asp Asp Ile Lys Ile Arg Pro Glu Leu Glu His Cys Glu Ser
Gln 625 630 635 640 cgc aac tcc atg tgg ttg ggt ctt gta tac ggc ttc
aag ggg cta atc 1968 Arg Asn Ser Met Trp Leu Gly Leu Val Tyr Gly
Phe Lys Gly Leu Ile 645 650 655 ctg gtg ttt ggc ctc ttt ttg gcg tac
gag acg cgc tcc att aaa gtg 2016 Leu Val Phe Gly Leu Phe Leu Ala
Tyr Glu Thr Arg Ser Ile Lys Val 660 665 670 aaa cag atc aac gat tcg
cgt tat gtg ggc atg agc atc tat aac gtg 2064 Lys Gln Ile Asn Asp
Ser Arg Tyr Val Gly Met Ser Ile Tyr Asn Val 675 680 685 gtc gtc ctt
tgc ctg ata aca gct ccg gtg ggc atg gtc att gca tcg 2112 Val Val
Leu Cys Leu Ile Thr Ala Pro Val Gly Met Val Ile Ala Ser 690 695 700
caa cag gac gcg tcc ttt gcc ttc gtt gct cta gct gtg ata ttc tgt
2160 Gln Gln Asp Ala Ser Phe Ala Phe Val Ala Leu Ala Val Ile Phe
Cys 705 710 715 720 tgt ttc cta agc atg ctg ctg ata ttt gtg cca aag
gtc att gag gtt 2208 Cys Phe Leu Ser Met Leu Leu Ile Phe Val Pro
Lys Val Ile Glu Val 725 730 735 ata cgt cat ccc aag gat aag gcc gaa
tcg aaa tac aat ccc gat tca 2256 Ile Arg His Pro Lys Asp Lys Ala
Glu Ser Lys Tyr Asn Pro Asp Ser 740 745 750 gcc ata tcg aaa gag gac
gaa gaa cgc tat cag aaa ctt gtt acc gaa 2304 Ala Ile Ser Lys Glu
Asp Glu Glu Arg Tyr Gln Lys Leu Val Thr Glu 755 760 765 aac gag caa
ttg caa cga tta ata aca cag aag gag gaa aag att cga 2352 Asn Glu
Gln Leu Gln Arg Leu Ile Thr Gln Lys Glu Glu Lys Ile Arg 770 775 780
gtc ctg cga cag cgt ctg gtg gag cgg ggc gac gcc aag ggc aca gaa
2400 Val Leu Arg Gln Arg Leu Val Glu Arg Gly Asp Ala Lys Gly Thr
Glu 785 790 795 800 ctg aat ggt gca aca ggt gtc gcc tcc gcc gcc gtt
gca aca act tcg 2448 Leu Asn Gly Ala Thr Gly Val Ala Ser Ala Ala
Val Ala Thr Thr Ser 805 810 815 cag ccc gct tcc ctc atc aac tca tca
gca cat gcc acg ccc gca gcc 2496 Gln Pro Ala Ser Leu Ile Asn Ser
Ser Ala His Ala Thr Pro Ala Ala 820 825 830 aca ctc gca atc aca caa
ggt gag tag 2523 Thr Leu Ala Ile Thr Gln Gly Glu 835 840 2 840 PRT
Drosophila melanogaster 2 Met Arg Lys Asp Met Thr Ser Asp Gly Ala
Val Thr Phe Trp Ile Phe 1 5 10 15 Leu Leu Cys Leu Ile Ala Ser Pro
His Leu Gln Gly Gly Val Ala Gly 20 25 30 Arg Pro Asp Glu Leu His
Ile Gly Gly Ile Phe Pro Ile Ala Gly Lys 35 40 45 Gly Gly Trp Gln
Gly Gly Gln Ala Cys Met Pro Ala Thr Arg Leu Ala 50 55 60 Leu Asp
Asp Val Asn Lys Gln Pro Asn Leu Leu Pro Gly Phe Lys Leu 65 70 75 80
Ile Leu His Ser Asn Asp Ser Glu Cys Glu Pro Gly Leu Gly Ala Ser 85
90 95 Val Met Tyr Asn Leu Leu Tyr Asn Lys Pro Gln Lys Leu Met Leu
Leu 100 105 110 Ala Gly Cys Ser Thr Val Cys Thr Thr Val Ala Glu Ala
Ala Lys Met 115 120 125 Trp Asn Leu Ile Val Leu Cys Tyr Gly Ala Ser
Ser Pro Ala Leu Ser 130 135 140 Asp Arg Lys Arg Phe Pro Thr Leu Phe
Arg Thr His Pro Ser Ala Thr 145 150 155 160 Val His Asn Pro Thr Arg
Ile Lys Leu Met Lys Lys Phe Gly Trp Ser 165 170 175 Arg Val Ala Ile
Leu Gln Gln Ala Glu Glu Val Phe Ile Ser Thr Val 180 185 190 Glu Asp
Leu Glu Asn Arg Cys Met Glu Ala Gly Val Glu Ile Val Thr 195 200 205
Arg Gln Ser Phe Leu Ser Asp Pro Thr Asp Ala Val Arg Asn Leu Arg 210
215 220 Arg Gln Asp Ala Arg Ile Ile Val Gly Leu Phe Tyr Val Val Ala
Ala 225 230 235 240 Arg Arg Val Leu Cys Glu Met Tyr Lys Gln Gln Leu
Tyr Gly Arg Ala 245 250 255 His Val Trp Phe Phe Ile Gly Trp Tyr Glu
Asp Asn Trp Tyr Glu Val 260 265 270 Asn Leu Lys Ala Glu Gly Ile Thr
Cys Thr Val Glu Gln Met Arg Ile 275 280 285 Ala Ala Glu Gly His Leu
Thr Thr Glu Ala Leu Met Trp Asn Gln Asn 290 295 300 Asn Gln Thr Thr
Ile Ser Gly Met Thr Ala Glu Glu Phe Arg His Arg 305 310 315 320 Leu
Asn Gln Ala Leu Ile Glu Glu Gly Tyr Asp Ile Asn His Asp Arg 325 330
335 Tyr Pro Glu Gly Tyr Gln Glu Ala Pro Leu Ala Tyr Asp Ala Val Trp
340 345 350 Ser Val Ala Leu Ala Phe Asn Lys Thr Met Glu Arg Leu Thr
Thr Gly 355 360 365 Lys Lys Ser Leu Arg Asp Phe Thr Tyr Thr Asp Lys
Glu Ile Ala Asp 370 375 380 Glu Ile Tyr Ala Ala Met Asn Ser Thr Gln
Phe Leu Gly Val Ser Gly 385 390 395 400 Val Val Ala Phe Ser Ser Gln
Gly Asp Arg Ile Ala Leu Thr Gln Ile 405 410 415 Glu Gln Met Ile Asp
Gly Lys Tyr Glu Lys Leu Gly Tyr Tyr Asp Thr 420 425 430 Gln Leu Asp
Asn Leu Ser Trp Leu Asn Thr Glu Gln Trp Ile Gly Gly 435 440 445 Lys
Val Pro Gln Asp Arg Thr Ile Val Thr His Val Leu Arg Thr Val 450 455
460 Ser Leu Pro Leu Phe Val Cys Met Cys Thr Ile Ser Ser Cys Gly Ile
465 470 475 480 Phe Val Ala Phe Ala Leu Ile Ile Phe Asn Ile Trp Asn
Lys His Arg 485 490 495 Arg Val Ile Gln Ser Ser His Pro Val Cys Asn
Thr Ile Met Leu Phe 500 505 510 Gly Val Ile Ile Cys Leu Ile Ser Val
Ile Leu Leu Gly Ile Asp Gly 515 520 525 Arg Phe Val Ser Pro Glu Glu
Tyr Pro Lys Ile Cys Gln Ala Arg Ala 530 535 540 Trp Leu Leu Ser Thr
Gly Phe Thr Leu Ala Tyr Gly Ala Met Phe Ser 545 550 555 560 Lys Val
Trp Arg Val His Arg Phe Thr Thr Lys Ala Lys Thr Asp Pro 565 570 575
Lys Lys Lys Val Glu Pro Trp Lys Leu Tyr Thr Met Val Ser Gly Leu 580
585 590 Leu Ser Ile Asp Leu Val Ile Leu Leu Ser Trp Gln Ile Phe Asp
Pro 595 600 605 Leu Gln Arg Tyr Leu Glu Thr Phe Pro Leu Glu Asp Pro
Val Ser Thr 610 615 620 Thr Asp Asp Ile Lys Ile Arg Pro Glu Leu Glu
His Cys Glu Ser Gln 625 630 635 640 Arg Asn Ser Met Trp Leu Gly Leu
Val Tyr Gly Phe Lys Gly Leu Ile 645 650 655 Leu Val Phe Gly Leu Phe
Leu Ala Tyr Glu Thr Arg Ser Ile Lys Val 660 665 670 Lys Gln Ile Asn
Asp Ser Arg Tyr Val Gly Met Ser Ile Tyr Asn Val 675 680 685 Val Val
Leu Cys Leu Ile Thr Ala Pro Val Gly Met Val Ile Ala Ser 690 695 700
Gln Gln Asp Ala Ser Phe Ala Phe Val Ala Leu Ala Val Ile Phe Cys 705
710 715 720 Cys Phe Leu Ser Met Leu Leu Ile Phe Val Pro Lys Val Ile
Glu Val 725 730 735 Ile Arg His Pro Lys Asp Lys Ala Glu Ser Lys Tyr
Asn Pro Asp Ser 740 745 750 Ala Ile Ser Lys Glu Asp Glu Glu Arg Tyr
Gln Lys Leu Val Thr Glu 755 760 765 Asn Glu Gln Leu Gln Arg Leu Ile
Thr Gln Lys Glu Glu Lys Ile Arg 770 775 780 Val Leu Arg Gln Arg Leu
Val Glu Arg Gly Asp Ala Lys Gly Thr Glu 785 790 795 800 Leu Asn Gly
Ala Thr Gly Val Ala Ser Ala Ala Val Ala Thr Thr Ser 805 810 815 Gln
Pro Ala Ser Leu Ile Asn Ser Ser Ala His Ala Thr Pro Ala Ala 820 825
830 Thr Leu Ala Ile Thr Gln Gly Glu 835 840 3 3663 DNA Drosophila
melanogaster CDS (1)..(3660) 3 atg ttc cgg cca agt tgg ttt cca ttc
gcc agc ctg ctg ttc ctg ctc 48 Met Phe Arg Pro Ser Trp Phe Pro Phe
Ala Ser Leu Leu Phe Leu Leu 1 5 10 15 ctt tgg agc acc gcc tgt ggc
agg aca gcc aag aga tcg gac gtc tac 96 Leu Trp Ser Thr Ala Cys Gly
Arg Thr Ala Lys Arg Ser Asp Val Tyr 20 25 30 ata gcg gga ttc ttc
ccg tac ggg gat ggc gtg gaa aac tcc tac acc 144 Ile Ala Gly Phe Phe
Pro Tyr Gly Asp Gly Val Glu Asn Ser Tyr Thr 35 40 45 ggt cgg ggc
gtt atg ccc agt gta aag ctc gcc ttg ggt cac gtt aat 192 Gly Arg Gly
Val Met Pro Ser Val Lys Leu Ala Leu Gly His Val Asn 50 55 60 gag
cat gga aag ata ctg gcc aac tac agg ctg cac atg tgg tgg aac 240 Glu
His Gly Lys Ile Leu Ala Asn Tyr Arg Leu His Met Trp Trp Asn 65 70
75 80 gac act cag tgc aat gct gct gtg ggc gta aag tcc ttc ttc gat
atg 288 Asp Thr Gln Cys Asn Ala Ala Val Gly Val Lys Ser Phe Phe Asp
Met 85 90 95 atg cat tcg ggt ccc aat aaa gtg atg ctc ttc ggc gct
gcg tgc acc 336 Met His Ser Gly Pro Asn Lys Val Met Leu Phe Gly Ala
Ala Cys Thr 100 105 110 cat gtg acc gat ccc ata gcc aag gcc agc aag
cac tgg cac ctc acc 384 His Val Thr Asp Pro Ile Ala Lys Ala Ser Lys
His Trp His Leu Thr 115 120 125 cag ctc agc tac gcg gac acc cat ccc
atg ttc acc aag gat gcg ttt 432 Gln Leu Ser Tyr Ala Asp Thr His Pro
Met Phe Thr Lys Asp Ala Phe 130 135
140 ccg aat ttc ttt cgc gtg gta ccc tcg gag aat gcc ttt aat gcg ccg
480 Pro Asn Phe Phe Arg Val Val Pro Ser Glu Asn Ala Phe Asn Ala Pro
145 150 155 160 cga ctg gcc ttg ctg aag gag ttc aat tgg acc aga gtg
ggc act gtc 528 Arg Leu Ala Leu Leu Lys Glu Phe Asn Trp Thr Arg Val
Gly Thr Val 165 170 175 tac cag aat gag cca cgc tat tcg ctg ccc cac
aat cac atg gtg gct 576 Tyr Gln Asn Glu Pro Arg Tyr Ser Leu Pro His
Asn His Met Val Ala 180 185 190 gac ctg gat gcc atg gag gtc gag gtg
gtg gaa acg cag agc ttc gtc 624 Asp Leu Asp Ala Met Glu Val Glu Val
Val Glu Thr Gln Ser Phe Val 195 200 205 aac gat gtg gct gaa tca ttg
aag aaa ctg cgc gag aag gac gtg agg 672 Asn Asp Val Ala Glu Ser Leu
Lys Lys Leu Arg Glu Lys Asp Val Arg 210 215 220 atc att ctg ggc aac
ttt aac gag cac ttt gca cgc aag gca ttc tgt 720 Ile Ile Leu Gly Asn
Phe Asn Glu His Phe Ala Arg Lys Ala Phe Cys 225 230 235 240 gag gct
tat aaa ttg gat atg tat ggc aga gcc tat caa tgg ctg atc 768 Glu Ala
Tyr Lys Leu Asp Met Tyr Gly Arg Ala Tyr Gln Trp Leu Ile 245 250 255
atg gct acc tat tcc acg gat tgg tgg aat gtc acg cag gac agc gag 816
Met Ala Thr Tyr Ser Thr Asp Trp Trp Asn Val Thr Gln Asp Ser Glu 260
265 270 tgc agt gtg gag gag atc gct aca gcc ttg gaa ggt gcc att cta
gtg 864 Cys Ser Val Glu Glu Ile Ala Thr Ala Leu Glu Gly Ala Ile Leu
Val 275 280 285 gat ctt ttg ccc ttg tcc acc agt ggt gac atc aca gtg
gct ggc att 912 Asp Leu Leu Pro Leu Ser Thr Ser Gly Asp Ile Thr Val
Ala Gly Ile 290 295 300 act gct gat gag tat ctt gtg gag tac gac aga
ctg cga ggc act gaa 960 Thr Ala Asp Glu Tyr Leu Val Glu Tyr Asp Arg
Leu Arg Gly Thr Glu 305 310 315 320 tat tcc cgc ttt cat ggc tat acc
tac gat ggt atc tgg gca gct gcc 1008 Tyr Ser Arg Phe His Gly Tyr
Thr Tyr Asp Gly Ile Trp Ala Ala Ala 325 330 335 ctg gcc att cag tat
gtg gcc gaa aag cga gag gat ctg cta aca cat 1056 Leu Ala Ile Gln
Tyr Val Ala Glu Lys Arg Glu Asp Leu Leu Thr His 340 345 350 ttt gat
tat cgc gtg aag gac tgg gag agt gtc ttc ctt gag gct cta 1104 Phe
Asp Tyr Arg Val Lys Asp Trp Glu Ser Val Phe Leu Glu Ala Leu 355 360
365 cgt aat aca tcc ttc gag ggt gtg acg gga ccc gtg cgt ttc tac aac
1152 Arg Asn Thr Ser Phe Glu Gly Val Thr Gly Pro Val Arg Phe Tyr
Asn 370 375 380 aac gag cgc aag gcc aac atc ctg atc aat cag ttt cag
ctg gga caa 1200 Asn Glu Arg Lys Ala Asn Ile Leu Ile Asn Gln Phe
Gln Leu Gly Gln 385 390 395 400 atg gaa aag atc ggg gaa tac cac tca
cag aag tca cac ttg gat tta 1248 Met Glu Lys Ile Gly Glu Tyr His
Ser Gln Lys Ser His Leu Asp Leu 405 410 415 agc ttg gga aaa cca gtc
aaa tgg gtg ggg aaa act cct ccc aag gat 1296 Ser Leu Gly Lys Pro
Val Lys Trp Val Gly Lys Thr Pro Pro Lys Asp 420 425 430 cgc act ttg
atc tac atc gag cac agt cag gtc aat cca acc ata tat 1344 Arg Thr
Leu Ile Tyr Ile Glu His Ser Gln Val Asn Pro Thr Ile Tyr 435 440 445
att gta tcg gct agt gct tcg gtc att gga gtg att att gcc aca gtt
1392 Ile Val Ser Ala Ser Ala Ser Val Ile Gly Val Ile Ile Ala Thr
Val 450 455 460 ttt ctg gcc ttt aac att aag tat cgc aat caa aga tac
atc aag atg 1440 Phe Leu Ala Phe Asn Ile Lys Tyr Arg Asn Gln Arg
Tyr Ile Lys Met 465 470 475 480 tcc agt ccc cat ttg aac aat ctg atc
att gtg ggc tgt atg att acc 1488 Ser Ser Pro His Leu Asn Asn Leu
Ile Ile Val Gly Cys Met Ile Thr 485 490 495 tat ttg agc atc att ttc
ctg ggt ctc gat acc aca tta agt agt gtg 1536 Tyr Leu Ser Ile Ile
Phe Leu Gly Leu Asp Thr Thr Leu Ser Ser Val 500 505 510 gca gct ttt
ccc tat atc tgc aca gct cga gcc tgg atc ttg atg gct 1584 Ala Ala
Phe Pro Tyr Ile Cys Thr Ala Arg Ala Trp Ile Leu Met Ala 515 520 525
gga ttc agt ctc agt ttt gga gcc atg ttc tcg aag acg tgg cgg gtg
1632 Gly Phe Ser Leu Ser Phe Gly Ala Met Phe Ser Lys Thr Trp Arg
Val 530 535 540 cat tcg ata ttc acc gat ctg aag ctc aat aag aag gtg
atc aag gac 1680 His Ser Ile Phe Thr Asp Leu Lys Leu Asn Lys Lys
Val Ile Lys Asp 545 550 555 560 tat caa ttg ttt atg gtt gtg ggc gtg
ctt ttg gcc att gat ata gcc 1728 Tyr Gln Leu Phe Met Val Val Gly
Val Leu Leu Ala Ile Asp Ile Ala 565 570 575 att ata acc acc tgg cag
att gcc gat ccc ttt tac cgc gaa act aaa 1776 Ile Ile Thr Thr Trp
Gln Ile Ala Asp Pro Phe Tyr Arg Glu Thr Lys 580 585 590 cag ttg gaa
ccc ttg cat cac gag aat att gat gat gtc ttg gtg atc 1824 Gln Leu
Glu Pro Leu His His Glu Asn Ile Asp Asp Val Leu Val Ile 595 600 605
ccc gaa aac gag tac tgc cag tct gag cac atg acc ata ttc gtt agc
1872 Pro Glu Asn Glu Tyr Cys Gln Ser Glu His Met Thr Ile Phe Val
Ser 610 615 620 att att tat gcc tac aag gga ctg ttg ttg gtt ttt ggc
gcc ttt ttg 1920 Ile Ile Tyr Ala Tyr Lys Gly Leu Leu Leu Val Phe
Gly Ala Phe Leu 625 630 635 640 gcc tgg gaa act cga cat gtt tct ata
ccg gct ctg aac gat tcc aag 1968 Ala Trp Glu Thr Arg His Val Ser
Ile Pro Ala Leu Asn Asp Ser Lys 645 650 655 cat att ggt ttc tcc gtt
tat aac gtg ttc atc act tgt ctg gcc gga 2016 His Ile Gly Phe Ser
Val Tyr Asn Val Phe Ile Thr Cys Leu Ala Gly 660 665 670 gcg gct ata
tcc ctg gtg cta tcg gat cga aag gat tta gtt ttt gtc 2064 Ala Ala
Ile Ser Leu Val Leu Ser Asp Arg Lys Asp Leu Val Phe Val 675 680 685
tta ctc tcg ttt ttt atc att ttt tgt acg aca gcc act ttg tgt ttg
2112 Leu Leu Ser Phe Phe Ile Ile Phe Cys Thr Thr Ala Thr Leu Cys
Leu 690 695 700 gtg ttc gta ccg aaa ttg gtg gag ctg aag cgg aat ccc
cag ggc gtg 2160 Val Phe Val Pro Lys Leu Val Glu Leu Lys Arg Asn
Pro Gln Gly Val 705 710 715 720 gtg gac aaa cgc gtt agg gcc acg ttg
aga ccc atg tcc aaa aac gga 2208 Val Asp Lys Arg Val Arg Ala Thr
Leu Arg Pro Met Ser Lys Asn Gly 725 730 735 cgc cgg gat tcc tcg gtg
tgc gaa ctg gag caa cga ttg cga gat gta 2256 Arg Arg Asp Ser Ser
Val Cys Glu Leu Glu Gln Arg Leu Arg Asp Val 740 745 750 aag aac aca
aac tgc cga ttc cga aag gcg ctg atg gag aag gag aac 2304 Lys Asn
Thr Asn Cys Arg Phe Arg Lys Ala Leu Met Glu Lys Glu Asn 755 760 765
gag ctg cag gcc tta atc cgc aag ctg gga ccc gag gca cgc aaa tgg
2352 Glu Leu Gln Ala Leu Ile Arg Lys Leu Gly Pro Glu Ala Arg Lys
Trp 770 775 780 atc gat ggg gtg acc tgc aca ggt ggc tcc aac gtc ggt
agc gaa ctg 2400 Ile Asp Gly Val Thr Cys Thr Gly Gly Ser Asn Val
Gly Ser Glu Leu 785 790 795 800 gag ccc ata ctg aac gat gac att gtt
agg ctc tca gct cca ccg gtg 2448 Glu Pro Ile Leu Asn Asp Asp Ile
Val Arg Leu Ser Ala Pro Pro Val 805 810 815 cgt cga gag atg ccc agc
acc aca gtt acc gag atg acg tcc gtg gat 2496 Arg Arg Glu Met Pro
Ser Thr Thr Val Thr Glu Met Thr Ser Val Asp 820 825 830 agt gtg acc
tcg act cat gtg gag atg gat aac tcc ttt gtg tcg gtg 2544 Ser Val
Thr Ser Thr His Val Glu Met Asp Asn Ser Phe Val Ser Val 835 840 845
cag tct aca gtg atg gcg cca tcg ctt cct ccc aaa aag aaa aag caa
2592 Gln Ser Thr Val Met Ala Pro Ser Leu Pro Pro Lys Lys Lys Lys
Gln 850 855 860 tcg att gta gag cac cac tcg cat gcc cct gct cca act
atg atg cag 2640 Ser Ile Val Glu His His Ser His Ala Pro Ala Pro
Thr Met Met Gln 865 870 875 880 ccc atc cag cag caa ctg cag cag cac
tta cag caa cat cag cag atg 2688 Pro Ile Gln Gln Gln Leu Gln Gln
His Leu Gln Gln His Gln Gln Met 885 890 895 cag cag cag cac ctg cag
cag cag caa cac cag cag atg caa cag caa 2736 Gln Gln Gln His Leu
Gln Gln Gln Gln His Gln Gln Met Gln Gln Gln 900 905 910 cag cag cag
cag cag cat cat cat cgc cat ctg gag aag aga aac tcg 2784 Gln Gln
Gln Gln Gln His His His Arg His Leu Glu Lys Arg Asn Ser 915 920 925
gtg tcc gct cag acc gat gat aat ata ggc agc atc acc agt acg gcg
2832 Val Ser Ala Gln Thr Asp Asp Asn Ile Gly Ser Ile Thr Ser Thr
Ala 930 935 940 ggc aag cgg agc gga gga gac tgc tcc agc atg cgg gag
agg cgt caa 2880 Gly Lys Arg Ser Gly Gly Asp Cys Ser Ser Met Arg
Glu Arg Arg Gln 945 950 955 960 tcg acc gcc tcc agg cac tac gac agt
ggc agc cag acg ccc acc gcc 2928 Ser Thr Ala Ser Arg His Tyr Asp
Ser Gly Ser Gln Thr Pro Thr Ala 965 970 975 cgg cca aag tac agc agc
tcg cac cgg aac tcc tcc acc aac atc tcc 2976 Arg Pro Lys Tyr Ser
Ser Ser His Arg Asn Ser Ser Thr Asn Ile Ser 980 985 990 aca tcg caa
tcg gag ttg agc aac atg tgt cca cac tca aag ccc agt 3024 Thr Ser
Gln Ser Glu Leu Ser Asn Met Cys Pro His Ser Lys Pro Ser 995 1000
1005 act ccg gct gtg att aag act ccc act gcc tcc gac cat cgc cgc
acc 3072 Thr Pro Ala Val Ile Lys Thr Pro Thr Ala Ser Asp His Arg
Arg Thr 1010 1015 1020 agc atg ggc tcc gct ctg aag tcc aat ttc gtg
gtt tca cag agt gac 3120 Ser Met Gly Ser Ala Leu Lys Ser Asn Phe
Val Val Ser Gln Ser Asp 1025 1030 1035 1040 ctc tgg gac acg cac acg
ctg tcg cac gcc aag cag cgc cag tcg ccg 3168 Leu Trp Asp Thr His
Thr Leu Ser His Ala Lys Gln Arg Gln Ser Pro 1045 1050 1055 cgg aac
tac gcc agt ccg cag cgc tgt gcg gaa cat cat ggc ggc cac 3216 Arg
Asn Tyr Ala Ser Pro Gln Arg Cys Ala Glu His His Gly Gly His 1060
1065 1070 ggg atg acc tat gac ccg aac acc acc tcg ccc atc cag cgg
tcc gtc 3264 Gly Met Thr Tyr Asp Pro Asn Thr Thr Ser Pro Ile Gln
Arg Ser Val 1075 1080 1085 tcc gag aag aac cgc aac aaa cat cgg cca
aaa ccg caa aag ggc acc 3312 Ser Glu Lys Asn Arg Asn Lys His Arg
Pro Lys Pro Gln Lys Gly Thr 1090 1095 1100 gtt tgc cag agc gag acg
gac agc gaa cgg gaa cga gat ccg ccg ccc 3360 Val Cys Gln Ser Glu
Thr Asp Ser Glu Arg Glu Arg Asp Pro Pro Pro 1105 1110 1115 1120 aac
agt cag ccg tgc gtc cag ccg cgt aag gtc agc cgg agc tct aac 3408
Asn Ser Gln Pro Cys Val Gln Pro Arg Lys Val Ser Arg Ser Ser Asn
1125 1130 1135 atc cag cac gcc gcc cac cac cac agt tcg ccc aat gtg
gcg ccc gat 3456 Ile Gln His Ala Ala His His His Ser Ser Pro Asn
Val Ala Pro Asp 1140 1145 1150 aag cag cgg agc agg cag cgc ggc aag
cag gat agc agc atc tac ggc 3504 Lys Gln Arg Ser Arg Gln Arg Gly
Lys Gln Asp Ser Ser Ile Tyr Gly 1155 1160 1165 gcc agc agc gag acg
gaa ctg ctc gag ggc gag acg gca att ttg ccc 3552 Ala Ser Ser Glu
Thr Glu Leu Leu Glu Gly Glu Thr Ala Ile Leu Pro 1170 1175 1180 atc
ttc cgg aaa ctc ctc acc gag aag agt ccc aac tat cgg ggc cgc 3600
Ile Phe Arg Lys Leu Leu Thr Glu Lys Ser Pro Asn Tyr Arg Gly Arg
1185 1190 1195 1200 agt gcc gtg ggc cag agc tgt ccg aat ata tcc atc
aaa tgc gat atc 3648 Ser Ala Val Gly Gln Ser Cys Pro Asn Ile Ser
Ile Lys Cys Asp Ile 1205 1210 1215 gtc gag tac ttg tag 3663 Val Glu
Tyr Leu 1220 4 1220 PRT Drosophila melanogaster 4 Met Phe Arg Pro
Ser Trp Phe Pro Phe Ala Ser Leu Leu Phe Leu Leu 1 5 10 15 Leu Trp
Ser Thr Ala Cys Gly Arg Thr Ala Lys Arg Ser Asp Val Tyr 20 25 30
Ile Ala Gly Phe Phe Pro Tyr Gly Asp Gly Val Glu Asn Ser Tyr Thr 35
40 45 Gly Arg Gly Val Met Pro Ser Val Lys Leu Ala Leu Gly His Val
Asn 50 55 60 Glu His Gly Lys Ile Leu Ala Asn Tyr Arg Leu His Met
Trp Trp Asn 65 70 75 80 Asp Thr Gln Cys Asn Ala Ala Val Gly Val Lys
Ser Phe Phe Asp Met 85 90 95 Met His Ser Gly Pro Asn Lys Val Met
Leu Phe Gly Ala Ala Cys Thr 100 105 110 His Val Thr Asp Pro Ile Ala
Lys Ala Ser Lys His Trp His Leu Thr 115 120 125 Gln Leu Ser Tyr Ala
Asp Thr His Pro Met Phe Thr Lys Asp Ala Phe 130 135 140 Pro Asn Phe
Phe Arg Val Val Pro Ser Glu Asn Ala Phe Asn Ala Pro 145 150 155 160
Arg Leu Ala Leu Leu Lys Glu Phe Asn Trp Thr Arg Val Gly Thr Val 165
170 175 Tyr Gln Asn Glu Pro Arg Tyr Ser Leu Pro His Asn His Met Val
Ala 180 185 190 Asp Leu Asp Ala Met Glu Val Glu Val Val Glu Thr Gln
Ser Phe Val 195 200 205 Asn Asp Val Ala Glu Ser Leu Lys Lys Leu Arg
Glu Lys Asp Val Arg 210 215 220 Ile Ile Leu Gly Asn Phe Asn Glu His
Phe Ala Arg Lys Ala Phe Cys 225 230 235 240 Glu Ala Tyr Lys Leu Asp
Met Tyr Gly Arg Ala Tyr Gln Trp Leu Ile 245 250 255 Met Ala Thr Tyr
Ser Thr Asp Trp Trp Asn Val Thr Gln Asp Ser Glu 260 265 270 Cys Ser
Val Glu Glu Ile Ala Thr Ala Leu Glu Gly Ala Ile Leu Val 275 280 285
Asp Leu Leu Pro Leu Ser Thr Ser Gly Asp Ile Thr Val Ala Gly Ile 290
295 300 Thr Ala Asp Glu Tyr Leu Val Glu Tyr Asp Arg Leu Arg Gly Thr
Glu 305 310 315 320 Tyr Ser Arg Phe His Gly Tyr Thr Tyr Asp Gly Ile
Trp Ala Ala Ala 325 330 335 Leu Ala Ile Gln Tyr Val Ala Glu Lys Arg
Glu Asp Leu Leu Thr His 340 345 350 Phe Asp Tyr Arg Val Lys Asp Trp
Glu Ser Val Phe Leu Glu Ala Leu 355 360 365 Arg Asn Thr Ser Phe Glu
Gly Val Thr Gly Pro Val Arg Phe Tyr Asn 370 375 380 Asn Glu Arg Lys
Ala Asn Ile Leu Ile Asn Gln Phe Gln Leu Gly Gln 385 390 395 400 Met
Glu Lys Ile Gly Glu Tyr His Ser Gln Lys Ser His Leu Asp Leu 405 410
415 Ser Leu Gly Lys Pro Val Lys Trp Val Gly Lys Thr Pro Pro Lys Asp
420 425 430 Arg Thr Leu Ile Tyr Ile Glu His Ser Gln Val Asn Pro Thr
Ile Tyr 435 440 445 Ile Val Ser Ala Ser Ala Ser Val Ile Gly Val Ile
Ile Ala Thr Val 450 455 460 Phe Leu Ala Phe Asn Ile Lys Tyr Arg Asn
Gln Arg Tyr Ile Lys Met 465 470 475 480 Ser Ser Pro His Leu Asn Asn
Leu Ile Ile Val Gly Cys Met Ile Thr 485 490 495 Tyr Leu Ser Ile Ile
Phe Leu Gly Leu Asp Thr Thr Leu Ser Ser Val 500 505 510 Ala Ala Phe
Pro Tyr Ile Cys Thr Ala Arg Ala Trp Ile Leu Met Ala 515 520 525 Gly
Phe Ser Leu Ser Phe Gly Ala Met Phe Ser Lys Thr Trp Arg Val 530 535
540 His Ser Ile Phe Thr Asp Leu Lys Leu Asn Lys Lys Val Ile Lys Asp
545 550 555 560 Tyr Gln Leu Phe Met Val Val Gly Val Leu Leu Ala Ile
Asp Ile Ala 565 570 575 Ile Ile Thr Thr Trp Gln Ile Ala Asp Pro Phe
Tyr Arg Glu Thr Lys 580 585 590 Gln Leu Glu Pro Leu His His Glu Asn
Ile Asp Asp Val Leu Val Ile 595 600 605 Pro Glu Asn Glu Tyr Cys Gln
Ser Glu His Met Thr Ile Phe Val Ser 610 615 620 Ile Ile Tyr Ala Tyr
Lys Gly Leu Leu Leu Val Phe Gly Ala Phe Leu 625 630 635 640 Ala Trp
Glu Thr Arg His Val Ser Ile Pro Ala Leu Asn Asp Ser Lys 645 650 655
His Ile Gly Phe Ser Val Tyr Asn Val Phe Ile Thr Cys Leu Ala Gly 660
665 670 Ala Ala Ile Ser Leu Val Leu Ser Asp Arg Lys Asp Leu Val Phe
Val 675 680 685
Leu Leu Ser Phe Phe Ile Ile Phe Cys Thr Thr Ala Thr Leu Cys Leu 690
695 700 Val Phe Val Pro Lys Leu Val Glu Leu Lys Arg Asn Pro Gln Gly
Val 705 710 715 720 Val Asp Lys Arg Val Arg Ala Thr Leu Arg Pro Met
Ser Lys Asn Gly 725 730 735 Arg Arg Asp Ser Ser Val Cys Glu Leu Glu
Gln Arg Leu Arg Asp Val 740 745 750 Lys Asn Thr Asn Cys Arg Phe Arg
Lys Ala Leu Met Glu Lys Glu Asn 755 760 765 Glu Leu Gln Ala Leu Ile
Arg Lys Leu Gly Pro Glu Ala Arg Lys Trp 770 775 780 Ile Asp Gly Val
Thr Cys Thr Gly Gly Ser Asn Val Gly Ser Glu Leu 785 790 795 800 Glu
Pro Ile Leu Asn Asp Asp Ile Val Arg Leu Ser Ala Pro Pro Val 805 810
815 Arg Arg Glu Met Pro Ser Thr Thr Val Thr Glu Met Thr Ser Val Asp
820 825 830 Ser Val Thr Ser Thr His Val Glu Met Asp Asn Ser Phe Val
Ser Val 835 840 845 Gln Ser Thr Val Met Ala Pro Ser Leu Pro Pro Lys
Lys Lys Lys Gln 850 855 860 Ser Ile Val Glu His His Ser His Ala Pro
Ala Pro Thr Met Met Gln 865 870 875 880 Pro Ile Gln Gln Gln Leu Gln
Gln His Leu Gln Gln His Gln Gln Met 885 890 895 Gln Gln Gln His Leu
Gln Gln Gln Gln His Gln Gln Met Gln Gln Gln 900 905 910 Gln Gln Gln
Gln Gln His His His Arg His Leu Glu Lys Arg Asn Ser 915 920 925 Val
Ser Ala Gln Thr Asp Asp Asn Ile Gly Ser Ile Thr Ser Thr Ala 930 935
940 Gly Lys Arg Ser Gly Gly Asp Cys Ser Ser Met Arg Glu Arg Arg Gln
945 950 955 960 Ser Thr Ala Ser Arg His Tyr Asp Ser Gly Ser Gln Thr
Pro Thr Ala 965 970 975 Arg Pro Lys Tyr Ser Ser Ser His Arg Asn Ser
Ser Thr Asn Ile Ser 980 985 990 Thr Ser Gln Ser Glu Leu Ser Asn Met
Cys Pro His Ser Lys Pro Ser 995 1000 1005 Thr Pro Ala Val Ile Lys
Thr Pro Thr Ala Ser Asp His Arg Arg Thr 1010 1015 1020 Ser Met Gly
Ser Ala Leu Lys Ser Asn Phe Val Val Ser Gln Ser Asp 1025 1030 1035
1040 Leu Trp Asp Thr His Thr Leu Ser His Ala Lys Gln Arg Gln Ser
Pro 1045 1050 1055 Arg Asn Tyr Ala Ser Pro Gln Arg Cys Ala Glu His
His Gly Gly His 1060 1065 1070 Gly Met Thr Tyr Asp Pro Asn Thr Thr
Ser Pro Ile Gln Arg Ser Val 1075 1080 1085 Ser Glu Lys Asn Arg Asn
Lys His Arg Pro Lys Pro Gln Lys Gly Thr 1090 1095 1100 Val Cys Gln
Ser Glu Thr Asp Ser Glu Arg Glu Arg Asp Pro Pro Pro 1105 1110 1115
1120 Asn Ser Gln Pro Cys Val Gln Pro Arg Lys Val Ser Arg Ser Ser
Asn 1125 1130 1135 Ile Gln His Ala Ala His His His Ser Ser Pro Asn
Val Ala Pro Asp 1140 1145 1150 Lys Gln Arg Ser Arg Gln Arg Gly Lys
Gln Asp Ser Ser Ile Tyr Gly 1155 1160 1165 Ala Ser Ser Glu Thr Glu
Leu Leu Glu Gly Glu Thr Ala Ile Leu Pro 1170 1175 1180 Ile Phe Arg
Lys Leu Leu Thr Glu Lys Ser Pro Asn Tyr Arg Gly Arg 1185 1190 1195
1200 Ser Ala Val Gly Gln Ser Cys Pro Asn Ile Ser Ile Lys Cys Asp
Ile 1205 1210 1215 Val Glu Tyr Leu 1220 5 3918 DNA Drosophila
melanogaster CDS (1)..(3915) 5 atg cgc ata att caa ccg gtc caa ggg
acc aga tac ggt cca tgg ccg 48 Met Arg Ile Ile Gln Pro Val Gln Gly
Thr Arg Tyr Gly Pro Trp Pro 1 5 10 15 gcc gtg gga ctg agg cta gtc
ctg gcc ctt gcc tgg gca acg tcg gca 96 Ala Val Gly Leu Arg Leu Val
Leu Ala Leu Ala Trp Ala Thr Ser Ala 20 25 30 gcg gct gcc atg gag
tca tca gcc gag ctg cag gcc ctg ggc cac gag 144 Ala Ala Ala Met Glu
Ser Ser Ala Glu Leu Gln Ala Leu Gly His Glu 35 40 45 gca att agg
cca ggt gct gcc tca att agc aca tcc agc cca tcc agc 192 Ala Ile Arg
Pro Gly Ala Ala Ser Ile Ser Thr Ser Ser Pro Ser Ser 50 55 60 tcg
cca ccc gga gaa tcg gca tcg act gtg act gca ggg ggg act ccg 240 Ser
Pro Pro Gly Glu Ser Ala Ser Thr Val Thr Ala Gly Gly Thr Pro 65 70
75 80 att cca ccg cgc tcc gat tgg aag tac aaa cgg acg aaa gtc aaa
cgc 288 Ile Pro Pro Arg Ser Asp Trp Lys Tyr Lys Arg Thr Lys Val Lys
Arg 85 90 95 cgg cag cag cgc ctc aat tcg cac agc aat ctg ccc gga
agc acc aat 336 Arg Gln Gln Arg Leu Asn Ser His Ser Asn Leu Pro Gly
Ser Thr Asn 100 105 110 gcc tcc cac gct cac cac ctc ctc aat ctg ccc
ccc agg cag cga tac 384 Ala Ser His Ala His His Leu Leu Asn Leu Pro
Pro Arg Gln Arg Tyr 115 120 125 ttg aag gtc aac cag gtg ttc gaa agc
gaa cgc cgc atg tcg ccg gcc 432 Leu Lys Val Asn Gln Val Phe Glu Ser
Glu Arg Arg Met Ser Pro Ala 130 135 140 gaa atg cag cgc aat cat ggc
aaa atc gtg ctg ctc gga ctc ttt gag 480 Glu Met Gln Arg Asn His Gly
Lys Ile Val Leu Leu Gly Leu Phe Glu 145 150 155 160 ctg tcc aca tcg
cgg gga cca cgt ccg gat ggt ctg agc gaa ttg gga 528 Leu Ser Thr Ser
Arg Gly Pro Arg Pro Asp Gly Leu Ser Glu Leu Gly 165 170 175 gct gcc
acc atg gcc gtg gaa cac atc aac cgc aag cgc ctg ctg ccg 576 Ala Ala
Thr Met Ala Val Glu His Ile Asn Arg Lys Arg Leu Leu Pro 180 185 190
ggc tac acc ctc gag ctc gtg acc aac gat act cag tgt gat cct gga 624
Gly Tyr Thr Leu Glu Leu Val Thr Asn Asp Thr Gln Cys Asp Pro Gly 195
200 205 gtg ggc gtg gat cgc ttc ttc cac gcc atc tac aca cag ccc tcg
acg 672 Val Gly Val Asp Arg Phe Phe His Ala Ile Tyr Thr Gln Pro Ser
Thr 210 215 220 agg atg gtg atg ctg ctg gga tcg gcc tgc tcg gag gtc
acc gag agc 720 Arg Met Val Met Leu Leu Gly Ser Ala Cys Ser Glu Val
Thr Glu Ser 225 230 235 240 ctg gcg aag gtg gtg ccc tac tgg aac atc
gtg cag gta tcc ttc ggt 768 Leu Ala Lys Val Val Pro Tyr Trp Asn Ile
Val Gln Val Ser Phe Gly 245 250 255 tcc aca tcg ccg gcg ttg agc gac
agg cgg gag ttc ccc tac ttc tac 816 Ser Thr Ser Pro Ala Leu Ser Asp
Arg Arg Glu Phe Pro Tyr Phe Tyr 260 265 270 agg aca gtg gcc ccg gac
tcc tca cac aat ccg gcg cgc atc gct ttc 864 Arg Thr Val Ala Pro Asp
Ser Ser His Asn Pro Ala Arg Ile Ala Phe 275 280 285 att cgg aag ttt
ggc tgg ggc acg gtg acc act ttc tcg cag aac gag 912 Ile Arg Lys Phe
Gly Trp Gly Thr Val Thr Thr Phe Ser Gln Asn Glu 290 295 300 gag gtt
cac tcg ctg gcg gtg aac aac ctg gtc acc gaa ctg gag gcg 960 Glu Val
His Ser Leu Ala Val Asn Asn Leu Val Thr Glu Leu Glu Ala 305 310 315
320 gcc aac ata tcc tgt gcc gcc acc atc acc ttt gcg gcc acc gac ttc
1008 Ala Asn Ile Ser Cys Ala Ala Thr Ile Thr Phe Ala Ala Thr Asp
Phe 325 330 335 aag gag cag ctg ctg cta ctt agg gag acg gac acg cgc
atc atc atc 1056 Lys Glu Gln Leu Leu Leu Leu Arg Glu Thr Asp Thr
Arg Ile Ile Ile 340 345 350 ggc agc ttc tcg cag gag ctg gcc ccc cag
atc ctg tgc gag gcc tac 1104 Gly Ser Phe Ser Gln Glu Leu Ala Pro
Gln Ile Leu Cys Glu Ala Tyr 355 360 365 agg ctt cga atg ttc ggg gcg
gac tac gcc tgg atc ctc cac gag agc 1152 Arg Leu Arg Met Phe Gly
Ala Asp Tyr Ala Trp Ile Leu His Glu Ser 370 375 380 atg ggg gct ccg
tgg tgg ccg gac cag cgc acc gcc tgc tct aac cac 1200 Met Gly Ala
Pro Trp Trp Pro Asp Gln Arg Thr Ala Cys Ser Asn His 385 390 395 400
gaa ctg cag ctg gcc gtc gag aac ctc atc gtg gtc tca acg cac aac
1248 Glu Leu Gln Leu Ala Val Glu Asn Leu Ile Val Val Ser Thr His
Asn 405 410 415 agc atc gtt gga aat aac gtc agc tat agt gga ctg aac
aat cac atg 1296 Ser Ile Val Gly Asn Asn Val Ser Tyr Ser Gly Leu
Asn Asn His Met 420 425 430 ttc aac tcc cag ctg cgc aag caa tcc gcc
cag ttc cac ggc cag gat 1344 Phe Asn Ser Gln Leu Arg Lys Gln Ser
Ala Gln Phe His Gly Gln Asp 435 440 445 gga ttt ggc tcc ggt tat ggt
ccc agg atc agt atc gct gca acg caa 1392 Gly Phe Gly Ser Gly Tyr
Gly Pro Arg Ile Ser Ile Ala Ala Thr Gln 450 455 460 tct gac tct cgt
cgg cgg agg aga agg ggc gtg gta ggc acc agc gga 1440 Ser Asp Ser
Arg Arg Arg Arg Arg Arg Gly Val Val Gly Thr Ser Gly 465 470 475 480
ggg cac ctc ttt ccg gag gcg atc tcg cag tac gcg ccg caa acc tac
1488 Gly His Leu Phe Pro Glu Ala Ile Ser Gln Tyr Ala Pro Gln Thr
Tyr 485 490 495 gac gcc gtg tgg gcc atc gcc ctg gcc ttg aga gcc gct
gag gag cac 1536 Asp Ala Val Trp Ala Ile Ala Leu Ala Leu Arg Ala
Ala Glu Glu His 500 505 510 tgg cgg cgg aac gag gag cag tcg aag ctg
gac gga ttc gat tac acc 1584 Trp Arg Arg Asn Glu Glu Gln Ser Lys
Leu Asp Gly Phe Asp Tyr Thr 515 520 525 cgc agc gac atg gcc tgg gag
ttc ctg cag caa atg ggc aag ctc cac 1632 Arg Ser Asp Met Ala Trp
Glu Phe Leu Gln Gln Met Gly Lys Leu His 530 535 540 ttc ctg gga gtg
tcg ggc ccc gtt tcc ttc agc ggc cca gat cgc gtt 1680 Phe Leu Gly
Val Ser Gly Pro Val Ser Phe Ser Gly Pro Asp Arg Val 545 550 555 560
ggc acc act gcc ttc tat caa atc cag cgc ggt ttg ctg gaa ccg gtg
1728 Gly Thr Thr Ala Phe Tyr Gln Ile Gln Arg Gly Leu Leu Glu Pro
Val 565 570 575 gcc ctc tac tat ccg gcc acg gat gcc ctg gac ttc cgg
tgt ccc cgc 1776 Ala Leu Tyr Tyr Pro Ala Thr Asp Ala Leu Asp Phe
Arg Cys Pro Arg 580 585 590 tgc cgg ccg gtg aag tgg cac agc ggg cag
gta ccc atc gcc aag cgg 1824 Cys Arg Pro Val Lys Trp His Ser Gly
Gln Val Pro Ile Ala Lys Arg 595 600 605 gtg ttc aag ctg cgg gtg gcg
acc atc gct cca ctg gcc ttc tac acc 1872 Val Phe Lys Leu Arg Val
Ala Thr Ile Ala Pro Leu Ala Phe Tyr Thr 610 615 620 atc gcc acc ctc
tcc agc gtg gga atc gct ctg gcc atc acc ttc ctg 1920 Ile Ala Thr
Leu Ser Ser Val Gly Ile Ala Leu Ala Ile Thr Phe Leu 625 630 635 640
gcg ttc aat ctg cac ttt cgg aag ctg aag gca att aaa ctt tcc agc
1968 Ala Phe Asn Leu His Phe Arg Lys Leu Lys Ala Ile Lys Leu Ser
Ser 645 650 655 ccg aag ctg agc aac atc acc gca gtg ggc tgc atc ttt
gtg tac gcc 2016 Pro Lys Leu Ser Asn Ile Thr Ala Val Gly Cys Ile
Phe Val Tyr Ala 660 665 670 acc gtc atc ctt ttg ggc ttg gac cac tcg
acg ctg ccc tcg gcg gag 2064 Thr Val Ile Leu Leu Gly Leu Asp His
Ser Thr Leu Pro Ser Ala Glu 675 680 685 gac tct ttc gca acg gtc tgc
acg gcc cgc gtc tat ctg ctc tcc gcc 2112 Asp Ser Phe Ala Thr Val
Cys Thr Ala Arg Val Tyr Leu Leu Ser Ala 690 695 700 gga ttc tcg ttg
gcc ttt gga tcg atg ttt gcc aag acc tac aga gtg 2160 Gly Phe Ser
Leu Ala Phe Gly Ser Met Phe Ala Lys Thr Tyr Arg Val 705 710 715 720
cat cgg ata ttc act cgt acc ggc agc gtt ttc aag gac aag atg ctg
2208 His Arg Ile Phe Thr Arg Thr Gly Ser Val Phe Lys Asp Lys Met
Leu 725 730 735 cag gac att caa ctg atc ttg ctc gtc ggc gga ttg ctt
ctg gtg gat 2256 Gln Asp Ile Gln Leu Ile Leu Leu Val Gly Gly Leu
Leu Leu Val Asp 740 745 750 gcg ctg ctc gta acc ctt tgg gtg gtc acc
gat cca atg gag cgc cat 2304 Ala Leu Leu Val Thr Leu Trp Val Val
Thr Asp Pro Met Glu Arg His 755 760 765 ctt cac aac ctg acg ctc gag
atc agt gcg act gat aga agt gtc gtt 2352 Leu His Asn Leu Thr Leu
Glu Ile Ser Ala Thr Asp Arg Ser Val Val 770 775 780 tac cag cct cag
gtt gaa gtt tgc cgt tcg cag cac acg caa acg tgg 2400 Tyr Gln Pro
Gln Val Glu Val Cys Arg Ser Gln His Thr Gln Thr Trp 785 790 795 800
ttg agt gtc ctg tac gcc tac aaa ggc ctt ctt ctt gtg gtg ggt gtc
2448 Leu Ser Val Leu Tyr Ala Tyr Lys Gly Leu Leu Leu Val Val Gly
Val 805 810 815 tat atg gcc tgg gag acg cgc cac gta aaa ata cct gct
ctc aat gac 2496 Tyr Met Ala Trp Glu Thr Arg His Val Lys Ile Pro
Ala Leu Asn Asp 820 825 830 tcg cag tac atc gga gtg tct gta tac agt
gtg gtc atc acc agc gcc 2544 Ser Gln Tyr Ile Gly Val Ser Val Tyr
Ser Val Val Ile Thr Ser Ala 835 840 845 atc gtc gtg gtg ctg gcc aac
ttg att tcg gag cga gtc acc ctg gcc 2592 Ile Val Val Val Leu Ala
Asn Leu Ile Ser Glu Arg Val Thr Leu Ala 850 855 860 ttc atc aca atc
aca gct ctg att tta acc agc acc act gca acc ctt 2640 Phe Ile Thr
Ile Thr Ala Leu Ile Leu Thr Ser Thr Thr Ala Thr Leu 865 870 875 880
tgt ctg ctt ttc atc cca aaa ctc cat gat att tgg gca aga aac gat
2688 Cys Leu Leu Phe Ile Pro Lys Leu His Asp Ile Trp Ala Arg Asn
Asp 885 890 895 att atc gat ccg gtt atc cac agt atg ggc ctt aag atg
gag tgc aac 2736 Ile Ile Asp Pro Val Ile His Ser Met Gly Leu Lys
Met Glu Cys Asn 900 905 910 aca cgc cga ttc gtg gtc gat gat cgc cga
gaa ctg cag tat cga gtg 2784 Thr Arg Arg Phe Val Val Asp Asp Arg
Arg Glu Leu Gln Tyr Arg Val 915 920 925 gag gtg caa aac agg gtc tat
aag aag gaa atc cag gct ctg gac gcc 2832 Glu Val Gln Asn Arg Val
Tyr Lys Lys Glu Ile Gln Ala Leu Asp Ala 930 935 940 gag att cga aag
ctg gag agg cta ctc gag tcg gga cta acc acc acc 2880 Glu Ile Arg
Lys Leu Glu Arg Leu Leu Glu Ser Gly Leu Thr Thr Thr 945 950 955 960
tcc acc aca act tcg tcg tcc aca tca ctc tta act ggg gga ggt cat
2928 Ser Thr Thr Thr Ser Ser Ser Thr Ser Leu Leu Thr Gly Gly Gly
His 965 970 975 cta aag cca gaa ctg acg gta acc agt ggc atc tcg cag
act ccg gct 2976 Leu Lys Pro Glu Leu Thr Val Thr Ser Gly Ile Ser
Gln Thr Pro Ala 980 985 990 gca agt aaa aac aga act cca agt atc tcg
gga ata ctg ccc aat ctc 3024 Ala Ser Lys Asn Arg Thr Pro Ser Ile
Ser Gly Ile Leu Pro Asn Leu 995 1000 1005 ctg ctt tcc gtg ctg cct
cct gtg att cca cgg gcc agt tgg ccg tca 3072 Leu Leu Ser Val Leu
Pro Pro Val Ile Pro Arg Ala Ser Trp Pro Ser 1010 1015 1020 gca gag
tac atg cag atc ccg atg agg cgt tct gtt acc ttt gcc tcc 3120 Ala
Glu Tyr Met Gln Ile Pro Met Arg Arg Ser Val Thr Phe Ala Ser 1025
1030 1035 1040 cag ccc caa tta gag gag gcc tgc ctg cct gca cag gac
ttg att aac 3168 Gln Pro Gln Leu Glu Glu Ala Cys Leu Pro Ala Gln
Asp Leu Ile Asn 1045 1050 1055 ctc cgt tta gcc cac cag cag gcc acg
gag gct aag acg ggc ttg ata 3216 Leu Arg Leu Ala His Gln Gln Ala
Thr Glu Ala Lys Thr Gly Leu Ile 1060 1065 1070 aac cga tta cga ggg
ata ttt tct cgc acc act tcg agc aac aag gga 3264 Asn Arg Leu Arg
Gly Ile Phe Ser Arg Thr Thr Ser Ser Asn Lys Gly 1075 1080 1085 tcc
acc gcc agc ttg gcg gac caa aag ggt ctg aag gcg gcc ttt aaa 3312
Ser Thr Ala Ser Leu Ala Asp Gln Lys Gly Leu Lys Ala Ala Phe Lys
1090 1095 1100 tcg cac atg gga ctg ttc acc cgc ctg att ccc tcc tct
caa acg gcg 3360 Ser His Met Gly Leu Phe Thr Arg Leu Ile Pro Ser
Ser Gln Thr Ala 1105 1110 1115 1120 tcc tgc aat gcc ata tac aat aat
cca aat cag gat tcc att ccc tca 3408 Ser Cys Asn Ala Ile Tyr Asn
Asn Pro Asn Gln Asp Ser Ile Pro Ser 1125 1130 1135 gag gcg tcc tcc
cac ccg aat ggt aac cac cta aag ccc atc cat agg 3456 Glu Ala Ser
Ser His Pro Asn Gly Asn His Leu Lys Pro Ile His Arg 1140 1145 1150
ggt tca ttg acc aaa agc ggt act cac ctg gat cac ctt acc aag gat
3504 Gly Ser Leu Thr Lys Ser Gly Thr His Leu Asp His Leu Thr Lys
Asp 1155 1160 1165 ccg aat ttc ctg cct atc ccc act att tct ggc ggt
gaa cag
ggg gac 3552 Pro Asn Phe Leu Pro Ile Pro Thr Ile Ser Gly Gly Glu
Gln Gly Asp 1170 1175 1180 caa acg ttg ggt gga aag tat gtg aaa ctg
ctg gag acc aag gtg aac 3600 Gln Thr Leu Gly Gly Lys Tyr Val Lys
Leu Leu Glu Thr Lys Val Asn 1185 1190 1195 1200 ttc caa ttg ccc agc
aac cgg aga cct tcg gtg gtg cag cag cca ccc 3648 Phe Gln Leu Pro
Ser Asn Arg Arg Pro Ser Val Val Gln Gln Pro Pro 1205 1210 1215 agt
tta agg gaa agg gta agg ggt tcg cca cgc ttt cca cac cgc atc 3696
Ser Leu Arg Glu Arg Val Arg Gly Ser Pro Arg Phe Pro His Arg Ile
1220 1225 1230 ctg ccg ccc act tgc agt ctc agc gcc ctg gcc gaa tcc
gag gac cgt 3744 Leu Pro Pro Thr Cys Ser Leu Ser Ala Leu Ala Glu
Ser Glu Asp Arg 1235 1240 1245 ccc gga gat agc acc tct atc ttg ggc
agc tgc aag tcc ata cct cgc 3792 Pro Gly Asp Ser Thr Ser Ile Leu
Gly Ser Cys Lys Ser Ile Pro Arg 1250 1255 1260 att tcg ctg cag cag
gtc acc agt gga ggc acc tgg aaa tcg atg gaa 3840 Ile Ser Leu Gln
Gln Val Thr Ser Gly Gly Thr Trp Lys Ser Met Glu 1265 1270 1275 1280
aca gtg ggc aag tcg agg ctt tcc ctc ggc gat tcc cag gaa gag gag
3888 Thr Val Gly Lys Ser Arg Leu Ser Leu Gly Asp Ser Gln Glu Glu
Glu 1285 1290 1295 cag cag gcg cct gcg aat ggc acc gaa taa 3918 Gln
Gln Ala Pro Ala Asn Gly Thr Glu 1300 1305 6 1305 PRT Drosophila
melanogaster 6 Met Arg Ile Ile Gln Pro Val Gln Gly Thr Arg Tyr Gly
Pro Trp Pro 1 5 10 15 Ala Val Gly Leu Arg Leu Val Leu Ala Leu Ala
Trp Ala Thr Ser Ala 20 25 30 Ala Ala Ala Met Glu Ser Ser Ala Glu
Leu Gln Ala Leu Gly His Glu 35 40 45 Ala Ile Arg Pro Gly Ala Ala
Ser Ile Ser Thr Ser Ser Pro Ser Ser 50 55 60 Ser Pro Pro Gly Glu
Ser Ala Ser Thr Val Thr Ala Gly Gly Thr Pro 65 70 75 80 Ile Pro Pro
Arg Ser Asp Trp Lys Tyr Lys Arg Thr Lys Val Lys Arg 85 90 95 Arg
Gln Gln Arg Leu Asn Ser His Ser Asn Leu Pro Gly Ser Thr Asn 100 105
110 Ala Ser His Ala His His Leu Leu Asn Leu Pro Pro Arg Gln Arg Tyr
115 120 125 Leu Lys Val Asn Gln Val Phe Glu Ser Glu Arg Arg Met Ser
Pro Ala 130 135 140 Glu Met Gln Arg Asn His Gly Lys Ile Val Leu Leu
Gly Leu Phe Glu 145 150 155 160 Leu Ser Thr Ser Arg Gly Pro Arg Pro
Asp Gly Leu Ser Glu Leu Gly 165 170 175 Ala Ala Thr Met Ala Val Glu
His Ile Asn Arg Lys Arg Leu Leu Pro 180 185 190 Gly Tyr Thr Leu Glu
Leu Val Thr Asn Asp Thr Gln Cys Asp Pro Gly 195 200 205 Val Gly Val
Asp Arg Phe Phe His Ala Ile Tyr Thr Gln Pro Ser Thr 210 215 220 Arg
Met Val Met Leu Leu Gly Ser Ala Cys Ser Glu Val Thr Glu Ser 225 230
235 240 Leu Ala Lys Val Val Pro Tyr Trp Asn Ile Val Gln Val Ser Phe
Gly 245 250 255 Ser Thr Ser Pro Ala Leu Ser Asp Arg Arg Glu Phe Pro
Tyr Phe Tyr 260 265 270 Arg Thr Val Ala Pro Asp Ser Ser His Asn Pro
Ala Arg Ile Ala Phe 275 280 285 Ile Arg Lys Phe Gly Trp Gly Thr Val
Thr Thr Phe Ser Gln Asn Glu 290 295 300 Glu Val His Ser Leu Ala Val
Asn Asn Leu Val Thr Glu Leu Glu Ala 305 310 315 320 Ala Asn Ile Ser
Cys Ala Ala Thr Ile Thr Phe Ala Ala Thr Asp Phe 325 330 335 Lys Glu
Gln Leu Leu Leu Leu Arg Glu Thr Asp Thr Arg Ile Ile Ile 340 345 350
Gly Ser Phe Ser Gln Glu Leu Ala Pro Gln Ile Leu Cys Glu Ala Tyr 355
360 365 Arg Leu Arg Met Phe Gly Ala Asp Tyr Ala Trp Ile Leu His Glu
Ser 370 375 380 Met Gly Ala Pro Trp Trp Pro Asp Gln Arg Thr Ala Cys
Ser Asn His 385 390 395 400 Glu Leu Gln Leu Ala Val Glu Asn Leu Ile
Val Val Ser Thr His Asn 405 410 415 Ser Ile Val Gly Asn Asn Val Ser
Tyr Ser Gly Leu Asn Asn His Met 420 425 430 Phe Asn Ser Gln Leu Arg
Lys Gln Ser Ala Gln Phe His Gly Gln Asp 435 440 445 Gly Phe Gly Ser
Gly Tyr Gly Pro Arg Ile Ser Ile Ala Ala Thr Gln 450 455 460 Ser Asp
Ser Arg Arg Arg Arg Arg Arg Gly Val Val Gly Thr Ser Gly 465 470 475
480 Gly His Leu Phe Pro Glu Ala Ile Ser Gln Tyr Ala Pro Gln Thr Tyr
485 490 495 Asp Ala Val Trp Ala Ile Ala Leu Ala Leu Arg Ala Ala Glu
Glu His 500 505 510 Trp Arg Arg Asn Glu Glu Gln Ser Lys Leu Asp Gly
Phe Asp Tyr Thr 515 520 525 Arg Ser Asp Met Ala Trp Glu Phe Leu Gln
Gln Met Gly Lys Leu His 530 535 540 Phe Leu Gly Val Ser Gly Pro Val
Ser Phe Ser Gly Pro Asp Arg Val 545 550 555 560 Gly Thr Thr Ala Phe
Tyr Gln Ile Gln Arg Gly Leu Leu Glu Pro Val 565 570 575 Ala Leu Tyr
Tyr Pro Ala Thr Asp Ala Leu Asp Phe Arg Cys Pro Arg 580 585 590 Cys
Arg Pro Val Lys Trp His Ser Gly Gln Val Pro Ile Ala Lys Arg 595 600
605 Val Phe Lys Leu Arg Val Ala Thr Ile Ala Pro Leu Ala Phe Tyr Thr
610 615 620 Ile Ala Thr Leu Ser Ser Val Gly Ile Ala Leu Ala Ile Thr
Phe Leu 625 630 635 640 Ala Phe Asn Leu His Phe Arg Lys Leu Lys Ala
Ile Lys Leu Ser Ser 645 650 655 Pro Lys Leu Ser Asn Ile Thr Ala Val
Gly Cys Ile Phe Val Tyr Ala 660 665 670 Thr Val Ile Leu Leu Gly Leu
Asp His Ser Thr Leu Pro Ser Ala Glu 675 680 685 Asp Ser Phe Ala Thr
Val Cys Thr Ala Arg Val Tyr Leu Leu Ser Ala 690 695 700 Gly Phe Ser
Leu Ala Phe Gly Ser Met Phe Ala Lys Thr Tyr Arg Val 705 710 715 720
His Arg Ile Phe Thr Arg Thr Gly Ser Val Phe Lys Asp Lys Met Leu 725
730 735 Gln Asp Ile Gln Leu Ile Leu Leu Val Gly Gly Leu Leu Leu Val
Asp 740 745 750 Ala Leu Leu Val Thr Leu Trp Val Val Thr Asp Pro Met
Glu Arg His 755 760 765 Leu His Asn Leu Thr Leu Glu Ile Ser Ala Thr
Asp Arg Ser Val Val 770 775 780 Tyr Gln Pro Gln Val Glu Val Cys Arg
Ser Gln His Thr Gln Thr Trp 785 790 795 800 Leu Ser Val Leu Tyr Ala
Tyr Lys Gly Leu Leu Leu Val Val Gly Val 805 810 815 Tyr Met Ala Trp
Glu Thr Arg His Val Lys Ile Pro Ala Leu Asn Asp 820 825 830 Ser Gln
Tyr Ile Gly Val Ser Val Tyr Ser Val Val Ile Thr Ser Ala 835 840 845
Ile Val Val Val Leu Ala Asn Leu Ile Ser Glu Arg Val Thr Leu Ala 850
855 860 Phe Ile Thr Ile Thr Ala Leu Ile Leu Thr Ser Thr Thr Ala Thr
Leu 865 870 875 880 Cys Leu Leu Phe Ile Pro Lys Leu His Asp Ile Trp
Ala Arg Asn Asp 885 890 895 Ile Ile Asp Pro Val Ile His Ser Met Gly
Leu Lys Met Glu Cys Asn 900 905 910 Thr Arg Arg Phe Val Val Asp Asp
Arg Arg Glu Leu Gln Tyr Arg Val 915 920 925 Glu Val Gln Asn Arg Val
Tyr Lys Lys Glu Ile Gln Ala Leu Asp Ala 930 935 940 Glu Ile Arg Lys
Leu Glu Arg Leu Leu Glu Ser Gly Leu Thr Thr Thr 945 950 955 960 Ser
Thr Thr Thr Ser Ser Ser Thr Ser Leu Leu Thr Gly Gly Gly His 965 970
975 Leu Lys Pro Glu Leu Thr Val Thr Ser Gly Ile Ser Gln Thr Pro Ala
980 985 990 Ala Ser Lys Asn Arg Thr Pro Ser Ile Ser Gly Ile Leu Pro
Asn Leu 995 1000 1005 Leu Leu Ser Val Leu Pro Pro Val Ile Pro Arg
Ala Ser Trp Pro Ser 1010 1015 1020 Ala Glu Tyr Met Gln Ile Pro Met
Arg Arg Ser Val Thr Phe Ala Ser 1025 1030 1035 1040 Gln Pro Gln Leu
Glu Glu Ala Cys Leu Pro Ala Gln Asp Leu Ile Asn 1045 1050 1055 Leu
Arg Leu Ala His Gln Gln Ala Thr Glu Ala Lys Thr Gly Leu Ile 1060
1065 1070 Asn Arg Leu Arg Gly Ile Phe Ser Arg Thr Thr Ser Ser Asn
Lys Gly 1075 1080 1085 Ser Thr Ala Ser Leu Ala Asp Gln Lys Gly Leu
Lys Ala Ala Phe Lys 1090 1095 1100 Ser His Met Gly Leu Phe Thr Arg
Leu Ile Pro Ser Ser Gln Thr Ala 1105 1110 1115 1120 Ser Cys Asn Ala
Ile Tyr Asn Asn Pro Asn Gln Asp Ser Ile Pro Ser 1125 1130 1135 Glu
Ala Ser Ser His Pro Asn Gly Asn His Leu Lys Pro Ile His Arg 1140
1145 1150 Gly Ser Leu Thr Lys Ser Gly Thr His Leu Asp His Leu Thr
Lys Asp 1155 1160 1165 Pro Asn Phe Leu Pro Ile Pro Thr Ile Ser Gly
Gly Glu Gln Gly Asp 1170 1175 1180 Gln Thr Leu Gly Gly Lys Tyr Val
Lys Leu Leu Glu Thr Lys Val Asn 1185 1190 1195 1200 Phe Gln Leu Pro
Ser Asn Arg Arg Pro Ser Val Val Gln Gln Pro Pro 1205 1210 1215 Ser
Leu Arg Glu Arg Val Arg Gly Ser Pro Arg Phe Pro His Arg Ile 1220
1225 1230 Leu Pro Pro Thr Cys Ser Leu Ser Ala Leu Ala Glu Ser Glu
Asp Arg 1235 1240 1245 Pro Gly Asp Ser Thr Ser Ile Leu Gly Ser Cys
Lys Ser Ile Pro Arg 1250 1255 1260 Ile Ser Leu Gln Gln Val Thr Ser
Gly Gly Thr Trp Lys Ser Met Glu 1265 1270 1275 1280 Thr Val Gly Lys
Ser Arg Leu Ser Leu Gly Asp Ser Gln Glu Glu Glu 1285 1290 1295 Gln
Gln Ala Pro Ala Asn Gly Thr Glu 1300 1305
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