U.S. patent application number 10/917242 was filed with the patent office on 2005-04-14 for novel human protocadherin proteins and polynucleotides encoding the same. Invention is credited to Miranda, Maricar, Turner, C. Alexander JR., Yu, Xuanchuan (Sean).
Application Number | 20050079522 10/917242 |
Document ID | / |
Family ID | 34107084 |
Filed Date | 2005-04-14 |
United States Patent Application | 20050079522 |
Kind Code | A1 |
Yu, Xuanchuan (Sean) ; et al. | April 14, 2005 |
Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
Inventors: | Yu, Xuanchuan (Sean); (Houston, TX) ; Miranda, Maricar; (Houston, TX) ; Turner, C. Alexander JR.; (The Woodlands, TX) |
Correspondence Address: |
Lance K. Ishimoto LEXICON GENETICS INCORPORATED 8800 Technology Forest Place The Woodlands TX 77381 US |
Family ID: | 34107084 |
Appl. No.: | 10/917242 |
Filed: | August 12, 2004 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
10917242 | Aug 12, 2004 | |||
10025225 | Dec 19, 2001 | |||
6852844 | ||||
60257257 | Dec 20, 2000 | |||
Current U.S. Class: | 435/6.16 ; 435/320.1; 435/325; 435/69.1; 530/350; 536/23.5 |
Current CPC Class: | C07K 14/705 20130101 |
Class at Publication: | 435/006 ; 435/069.1; 435/320.1; 435/325; 530/350; 536/023.5 |
International Class: | C12Q 001/68; C07H 021/04; C07K 014/705 |
Sequence CWU 1
1
8 1 13770 DNA homo sapiens 1 atggatataa ttatgggaca ctgtgtgggc
acacggcctc ctgcttgttg cctcatcctc 60 ctgcttttca agcttttggc
cactgtctcc caggggctgc cagggactgg acccctgggc 120 ttccacttca
cacattccat ttataatgct accgtgtatg agaactcagc agcaaggacc 180
tacgtcaaca gccagagtag aatgggcatc accttaatag atctatcctg ggatatcaaa
240 tacagaatag tgtccggaga cgaggaaggc tttttcaaag cagaggaagt
catcattgca 300 gatttctgtt ttctcagaat aagaactaaa ggtggcaatt
ctgccatatt aaatagggaa 360 atccaggata attatttatt gatagtaaaa
ggttctgtca gaggagagga tttggaagca 420 tggaccaaag tgaatataca
ggttttagat atgaatgatc tgagaccttt gttttcaccc 480 acaacatact
ctgttaccat agcagaaagc acacctctaa ggactagtgt tgcccaggtg 540
actgcaacag acgcagatat tggttccaat ggagaattct actactactt taaaaataaa
600 gttgatctct tttcagttca ccccacgagt ggtgtcatct ccttaagtgg
tcgattaaat 660 tatgatgaaa agaataggta tgatctggaa attttggctg
tggaccgggg aatgaaactg 720 tatgggaaca atggagtgag cagtactgca
aagctttatg ttcacattga gcgcataaat 780 gaacatgccc caacaatcca
tgtagtcact catgttcctt tctcgttgga aaaagagcca 840 acatatgcag
tggtgacagt tgatgactta gatgatggag cgaatggaga gatcgaatct 900
gtttccattg tggctgggga tcctttagat cagttcttcc tggctaagga aggaaagtgg
960 ttgaatgagt acaagattaa ggagaggaag cagattgact gggagagctt
tccctatggc 1020 tacaatctca ctcttcaagc aaaagacaag ggatctcctc
aaaaatgttc agcattaaag 1080 gcagtctaca ttggcaaccc cacaagagac
actgtcccca ttagatttga aaaagaagtg 1140 tacgatgtga gcataagtga
attttcccct cctggtgtcg tggttgctat agtaaaatta 1200 agtcctgaac
cgatagatgt ggaatacaaa ttatctcctg gtgaggatgc agtgtacttt 1260
aaaattaatc ctcggtcggg tctgattgtt acagcacggc cactgaatac tgttaagaag
1320 gaggtttata aactggaggt gacaaacaag gaaggagatt taaaagcaca
ggtcaccatc 1380 agcatagaag atgcaaatga ccacacccca gaatttcagc
aaccactgta tgatgcttat 1440 gtgaatgaaa gtgtcccagt gggaaccagc
gttctaacag tttcagcttc tgataaggat 1500 aaaggagaaa atgggtacat
cacctatagt atcgctagcc tgaatttgtt accatttgtc 1560 attaatcagt
ttacaggtgt tattagcaca actgaagaac tggattttga atcctcccca 1620
gaaatttaca gattcattgt tagagcctct gactggggtt caccataccg ccatgaaagt
1680 gaggtcaatg tgactattcg aataggaaat gtcaacgaca acagccctct
ctttgaaaaa 1740 gtggcttgcc agggagttat ttcatatgac tttccagttg
gtggtcacat cacagcagtc 1800 tcagcgatcg atatcgatga acttgaactt
gtaaagtaca aaatcatttc tggaaatgaa 1860 cttggcttct tttatttaaa
cccagattct ggtgttttac agcttaaaaa atcactgaca 1920 aattctggca
ttaaaaatgg caattttgcc ctcagaatta cagcaactga tggagagaat 1980
cttgcagacc ccatgtctat taacatttca gtcctacatg ggaaagtgtc ttcaaagagc
2040 ttcagttgca gagaaactcg tgtggctcaa aagctggcag agaaactact
cattaaggca 2100 aaagcaaatg ggaaactgaa tctggaagat ggatttcttg
acttttattc aattaataga 2160 cagggaccat attttgacaa gtcttttcct
tctgatgtgg ctgtaaagga ggatctgcca 2220 gttggtgcta acattctgaa
gattaaagcc tatgatgccg actctggctt caatggaaaa 2280 gtgctattta
caatatcaga tggaaatacg gatagttgct ttaatattga tatggagact 2340
gggcagctta aagtccttat gcccatggat cgagaacaca cagacctcta tctccttaat
2400 atcaccatct atgacttagg taatccacag aaatcgtcat ggagactgct
gaccatcaat 2460 gtggaggatg ctaatgacaa tagcccagtt tttattcaag
acagttactc agttaacatt 2520 cttgaaagtt caggcattgg tactgaaatc
attcaagtgg aagccagaga caaagactta 2580 ggttctaatg gtgaagtgac
ttactcagtc ttgacagata cacagcagtt tgccatcaat 2640 agctcaactg
gaatcgttta tgtagccgac cagttggacc gggaatccaa agccaattat 2700
tctttgaaaa tagaagccag ggacaaggca gagagtggtc agcagctgtt ttcagttgtc
2760 actcttaaag tttttttaga tgatgtcaat gactgctccc cagctttcat
tcccagtagc 2820 tatagtgtga aggttcttga agatctccct gttggcactg
tcattgcttg gcttgagacc 2880 catgatccag atcttggact ggggggtcaa
gtgcgctatt ctttggtcaa tgactataat 2940 gggagatttg aaatagataa
agcaagtggt gccatccgct tgagcaaaga gcttgattat 3000 gagaaacagc
agttctataa ccttactgtg cgggccaaag acaaagggcg gcctgtctct 3060
ctgtcatctg tttcctttgt tgaggtggaa gtggtggatg tcaatgaaaa cctccacact
3120 ccctatttcc cagactttgc tgttgttgga tctgtaaagg aaaactcacg
cattggaaca 3180 agcgtgctgc aggtgactgc tcgagatgaa gactccggaa
gggatggaga gatccagtac 3240 tccatcaggg atggcagtgg tcttggaagg
ttcagtatag acgacgagag tggggtcatc 3300 actgccgcag acattcttga
tcgggagaca atggggtcat actggctaac agtgtatgcc 3360 acagacaggg
gcgttgttcc actctactcc accattgagg tctacattga agttgaagat 3420
gtgaatgaca atgccccgct gacctcagaa cctatatatt atcctgttgt catggaaaac
3480 tctccaaagg acgtatctgt cattcagatc caggctgaag atcctgactc
cagttccaat 3540 gaaaaactga catacaggat tacaagtgga aatcctcaga
atttttttgc catcaatatc 3600 aaaacaggtc tgattacaac aacttcaagg
aaattggatc gagaacagca ggcagaacat 3660 tttctggagg tgactgtgac
agatggtggt ccctctccaa aacagtcaac catttgggtg 3720 gtggttcagg
ttctagatga aaatgacaac aagccccagt tcccagagaa ggtctaccag 3780
atcaagctgc cagaacgtga ccgaaagaag agaggagaac cgatttacag ggcttttgca
3840 tttgatagag atgagggccc caacgcagaa atctcctaca gtattgtgga
tgggaatgat 3900 gacggaaagt tctttattga ccctaaaact gggatggttt
cttctagaaa gcagtttaca 3960 gcaggcagtt atgacatcct aacgataaag
gcagtggaca atgggcgccc acagaaatcc 4020 tccacggccc gcctccacat
tgaatggatt aagaaaccac ccccttcacc tataccattg 4080 accttcgatg
agccgtttta taacttcaca gtcatggaaa gtgatagagt gactgaaatt 4140
gtaggggtgg tgtctgtgca gccagctaac acccctctgt ggtttgacat agttgggggg
4200 aattttgaca gcgcttttga tgcagagaag ggtgttggga caattgtcat
cgcaaaacct 4260 ttggatgcag agcagaggtc catctataat atgagtgtgg
aagtcaccga tgggacaaat 4320 gttgctgtta ctcaggtatt tatcaaagtg
ctggataata atgataatgg cccagaattc 4380 tctcagccga attacgatgt
gacaatttcc gaggatgtgc ttccagacac ggagatcctg 4440 cagattgaag
ccacagatag agatgagaag cacaagctga gctacactgt tcatagcagc 4500
atcgactcca tcagcatgag aaaattccgg attgacccta gcactggcgt gctctatact
4560 gccgagaggc tggaccatga ggcccaggac aagcacattc tcaacataat
ggtcagagat 4620 caggagtttc cttatcgaag aaacttggcc cgagtcattg
tgaatgtgga ggatgctaat 4680 gatcacagtc cttattttac caacccactg
tatgaagcgt ctgtgtttga atctgctgct 4740 ctgggatcag ctgttctgca
agtgacggct ctggacaaag acaaaggaga aaatgcagaa 4800 ctcatatata
ccatagaagc agggaacact gggaacatgt ttaagatcga accggtccta 4860
ggcatcatca ccatttgcaa agaaccagac atgacgacga tgggtcagtt tgtcctatcc
4920 atcaaagtca cagatcaggg atccccgcca atgtctgcta ctgcaattgt
gcgcatttcc 4980 gtcaccatgt ctgacaattc tcaccccaag ttcattcaca
aagactacca agcagaagta 5040 aatgaaaatg ttgacattgg aacatcagtc
attctaatct ctgccatcag tcaatctacc 5100 ctcatttatg aagtcaaaga
tggagacatt aatgggatct ttaccataaa tccatattct 5160 ggagtcatca
ccactcagaa ggccctggat tatgagcgca catcctctta tcaactcatc 5220
attcaggcca ccaatatggc aggaatggct tccaatgcta cagtcaatat tcagattgtt
5280 gatgaaaatg ataatgcccc agtttttctc ttttctcaat actcaggcag
cctaagtgag 5340 gctgccccaa ttaatagcat tgtcaggagc ttggataaca
gcccactggt gattcgagcc 5400 acagatgctg acagcaaccg gaatgctctg
cttgtgtatc agattgtgga gtcaacagca 5460 aaaaagtttt tcacggtgga
ctccagtaca ggtgcaatca gaacaattgc caacctggac 5520 catgaaacca
ttgcccattt ccattttcat gtgcatgtga gagacagtgg tagcccccaa 5580
ctgactgcag agagtcccgt tgaagtcaac attgaggtga cagatgtgaa tgataaccca
5640 cctgttttta ctcaggctgt gtttgagact atcttacttc tacctaccta
tgttggagtg 5700 gaggttctga aagttagtgc cacagatcct gactctgagg
taccccctga actgacatac 5760 agcctaatgg aaggcagttt ggatcatttt
ttaattgact caaacagtgg agtacttacc 5820 ataaaaaaca acaacctctc
caaggatcac tacatgctga tagttaaggt gtctgatgga 5880 aagttctaca
gtacctccat ggtcaccatc atggttaaag aagccatgga cagcggcctc 5940
cactttacac aaagcttcta ttccacctca atctcagaga acaacactaa cataaccaaa
6000 gttgctattg tcaatgcagt tggaaatcgc cttaatgagc ccttaaaata
cagcatctta 6060 aacccaggaa ataagttcaa gataaaatct acctcagggg
tcattcagac gactggagtc 6120 ccctttgacc gtgaagaaca agagttatat
gagctggtgg tagaagccag ccgtgagctg 6180 gaccatctgc gtgtggccag
agtggtggtc agggttaaca ttgaagacat aaatgacaat 6240 tctccagtct
ttgtgggcct cccatactat gctgctgttc aagtggatgc ggaacccggg 6300
actctgattt atcaggtgac agccattgac aaagataaag gtccaaatgg agaagtgacc
6360 tatgtcctgc aggatgacta tggccacttt gaaattaacc ctaattcagg
gaatgttatt 6420 ttaaaggaag cattcaactc tgacttgtcc aacattgagt
atggagtcac catcctagcc 6480 aaggatggcg gaaaaccttc tttgtctaca
tctgtggagc ttcccatcac tattgtcaac 6540 aaagcaatgc ctgtgtttga
taagcccttt tatacagcat ctgtcaatga agacatcaga 6600 atgaacacac
ccatcctaag catcaatgcc accagtccag aaggccaagg catcatatat 6660
atcattatcg atggggaccc ttttaaacag tttaacattg actttgacac tggggtcctg
6720 aaagttgtta gccctttgga ttatgaagtt acatctgctt acaagctgac
aataagagcc 6780 agcgacgccc ttactggtgc tagggctgaa gtcactgttg
acttgctagt taatgatgta 6840 aatgacaacc cccctatttt cgatcagcct
acatacaata caacactatc agaagcatct 6900 cttattggga cacctgtttt
acaagttgtc tctattgatg cagactcaga aaacaataaa 6960 atggtacatt
atcagattgt ccaggatacc tacaatagca cagattattt tcacatagat 7020
agctcaagtg gcttaatcct gacagcacga atgctggacc atgagttagt acaacactgc
7080 actttgaaag tcagatcaat agatagtggc ttcccatcac tgagcagtga
ggttctcgtt 7140 catatctaca tctctgatgt aaatgacaac cctccagttt
ttaatcagct catttatgag 7200 tcatatgtga gtgaattagc cccccggggc
cattttgtaa cctgtgtaca agcctctgat 7260 gcagacagct ctgattttga
ccggttggaa tatagcattt tatctgggaa tgaccggacg 7320 agctttctga
tggacagcaa gagtggagtt atcacattgt ccaaccatcg gaagcagcgg 7380
atggagcctc tgtacagtct caatgtgtct gtctctgatg ggttgttcac cagcactgca
7440 caggtgcata ttagggtact tggggctaac ttgtacagcc ctgccttttc
acaaagcaca 7500 tacgtagctg aggtgagaga gaacgtggct gcaggaacaa
aggtaattca tgttcgagcc 7560 acagatggtg atccagggac ttatgggcag
atcagctatg ccatcatcaa tgactttgcc 7620 aaggatcgat tcctcataga
cagcaatggg caggtcatca ccacagaaag gctagaccgg 7680 gaaaaccctc
tagaagggga tgttagtatt tttgtgaggg cccttgatgg tggagggaga 7740
acaactttct gcactgtgag agtgattgtt gtggatgaaa atgacaatgc tccccagttc
7800 atgacagtgg aatatagagc cagtgtcagg gcagatgttg gaaggggcca
cttggtcact 7860 caagttcaag ccatagatcc cgatgatgga gcaaattcaa
ggattactta ttccctctat 7920 agcgaggcct ctgtttcagt ggccgacctc
ctggaaatcg atcctgacaa tggctggatg 7980 gtcacaaagg gtaattttaa
ccagctgaaa aatacagtgc tttcgttctt tgtcaaagca 8040 gtagatgggg
gcatcccagt aaagcactcc ctcattcctg tctatatcca cgtcttgccc 8100
cctgaaacgt tcttgccatc attcacccag tctcagtatt cctttaccat tgcagaagat
8160 acagccattg ggagtacagt ggacaccctg aggattttgc ccagtcagaa
tgtctggttc 8220 agcacagtta atggggaacg gccagaaaat aacaaagggg
gcgtattcgt catagaacag 8280 gaaacaggca ctattaagct tgacaaacgc
cttgaccgtg aaaccagccc agctttccac 8340 tttaaagtag cagccactat
acccctggac aaagtagaca ttgtgtttac tgtggatgta 8400 gatatcaagg
tattggattt gaatgacaac aagccagtct ttgaaacttc aagctatgac 8460
accattataa tggaagggat gcctgttggc accaaactca cacaagtgag agctattgat
8520 atggactggg gagccaatgg acaagtcact tactccctcc actcggattc
ccagcccgaa 8580 aaggtaatgg aagcattcaa tattgacagc aacacgggct
ggatcagtac cttgaaggac 8640 ctagatcacg agacagaccc cacattcacc
ttctctgtgg tggcctctga ccttggagag 8700 gcattctctc tttcctccac
ggccttggtc tctgtcagag tgacagatat aaatgacaat 8760 gcaccagtct
tcgcgcagga agtgtaccga gggaatgtga aggagagcga cccaccgggc 8820
gaggtggtag ccgtcctcag cacctgggac agagacacat ccgacgttaa tcgccaagtg
8880 agctaccata ttacaggagg aaaccctcga ggaaggtttg ctctgggcct
ggtgcaaagt 8940 gagtggaagg tctatgtgaa gaggcctcta gacagagaag
aacaggacat ttactttctc 9000 aatatcactg ccactgatgg gctttttgtc
acacaggcca tggtggaagt gagcgtcagt 9060 gatgtgaatg acaatagccc
agtgtgtgat caggttgcat atacagcatt acttcctgaa 9120 gacattccat
caaataaaat catcctgaaa gtcagtgcaa aggatgctga tattggatcc 9180
aatggatata tacgatactc actctatgga tctggaaaca gtgaattttt tctagatcca
9240 gaaagtggcg agttaaaaac cttggctctg ttggaccggg agaggatccc
cgtgtacagc 9300 ctgatggcca aggccactga cgggggtggc aggttctgcc
agtccaacat ccacctaatc 9360 ctggaggatg tgaatgataa cccccctgtg
ttttcttctg accactacaa cacctgtgtc 9420 tatgagaaca cagccaccaa
ggctctgttg accagagttc aagccgtgga ccccgacatt 9480 ggcatcaata
ggaaggtcgt gtactccctg gcagactcag ctggtggggt cttctccatt 9540
gacagctcat ctggcatcat catcctggag cagccactgg accgtgagca gcagtcttcg
9600 tacaacatca gcgtgcgggc cactgaccag agtcctggac agtccctgtc
ctctctcact 9660 actgtcacca tcaccgttct ggacattaat gacaaccccc
ctgtgtttga gaggagggac 9720 tacctggtga cggtgcctga ggacacctcc
cctggcaccc aagtccttgc tgtttttgcc 9780 accagcaaag atattggcac
aaatgctgag atcacttatc tcatccggtc tgggaacgaa 9840 caagggaaat
ttaagatcaa ccccaagaca gggggtattt ctgtctctga agtcctggac 9900
tatgaattat gcaaaaggtt ttacctggta gtggaagcca aagatggggg caccccagct
9960 ctcagcgctg tggccactgt caacatcaac ctcacagatg ttaatgacaa
ccctcccaag 10020 ttcagccaag acgtctacag tgcggttatc agtgaagacg
ccttggtggg agactctgtc 10080 attttgctaa tagcagaaga tgtagacagc
cagcccaacg gacagattca tttttccatt 10140 gtgaatggag atcgggacaa
tgaatttact gtagatcctg tcttgggact tgtgaaagtt 10200 aagaagaaat
tggaccggga acgggtgtct ggatactctc tgcttgtcca ggccgtagac 10260
agtggcattc ctgcaatgtc atcaactgca actgtcaaca ttgatatttc tgatgtgaat
10320 gacaacagcc cggtgtttac acctgccaac tatactgctg tgattcagga
aaataagcca 10380 gtgggcacca gcatcttgca gctggtggtg acagacagag
actcctttca caatgggcct 10440 cccttttcat tctctatttt gtcgggaaat
gaagaggagg agtttgtgtt ggaccctcat 10500 gggatcttgc ggtcggctgt
ggtcttccag cacacagagt ctctggaata cgtgttgtgt 10560 gtccaggcaa
aggattcagg caaaccccag caagtttctc acacttacat ccgcgtgcga 10620
gtcattgagg aaagcaccca caagcccaca gccattcccc tggaaatttt cattgtcacc
10680 atggaggatg actttcctgg tggggtcatt gggaagattc atgccacaga
tcaagacatg 10740 tatgatgtgc tcacatttgc cctgaaatcg gagcagaaaa
gcttatttaa agtgaacagt 10800 cacgatggga aaatcatcgc cctgggaggc
ctggacagcg gcaagtatgt cctgaatgtg 10860 tctgtgagtg atggtcgctt
ccaggtaccc attgatgtgg tcgtgcatgt ggagcagttg 10920 gtgcatgaga
tgctgcagaa cactgtcacc atccgctttg aaaatgtgtc ccctgaggac 10980
ttcgtggggc tgcacatgca tgggttccgg cgcaccctgc ggaatgcagt cctcacccag
11040 aagcaggaca gcctgcgcat catcagcatc cagcccgtgg caggcaccaa
ccaactggac 11100 atgctgtttg cggtggagat gcacagcagc gagttctaca
agccagccta cctgatccag 11160 aagctgtcca atgctagaag acacctggag
aatatcatgc gcatctcagc catcttggag 11220 aagaactgct cagggctgga
ctgtcaggaa cagcattgtg agcaaggctt gtcactcgat 11280 tcccacgcgc
tcatgaccta cagcacggct cgcatcagct ttgtgtgtcc gcgtttctac 11340
aggaacgtgc gttgcacctg caatggagga ctgtgtccgg ggtccaacga tccttgtgtg
11400 gagaagccgt gtccagggga catgcagtgt gtcggttatg aagccagcag
gagaccgttc 11460 ctctgccagt gtccaccagg gaagctcgga gagtgctcag
ggcacacttc tctcagcttt 11520 gctggaaaca gttacatcaa atatcggctt
tctgaaaata gcaaagaaga ggatttcaaa 11580 ctagctctgc gtcttcgaac
actgcaaagc aatgggatta taatgtacac cagagcaaat 11640 ccctgcataa
ttctgaagat tgtggatggc aagctgtggt tccagctgga ctgcggcagc 11700
ggccctggaa tcttgggcat ctcgggccgt gctgtcaacg acgggagctg gcactcggtc
11760 ttcctggagc tcaaccgcaa tttcacgagc ctgtccctgg atgacagcta
cgtggagcgg 11820 cgccgggcgc ccctctactt ccagacgctg agcactgaga
gtagcatcta cttcggcgcc 11880 ctggtgcaag cggataacat ccgcagcctg
actgacacgc gggtcacgca ggtgctcagc 11940 ggcttccagg gctgcctgga
ctcggtgata ctgaataaca atgagctgcc gctgcagaac 12000 aagcgcagca
gcttcgcgga ggtggtgggc ctgacggagc tgaagctggg ctgcgtgctc 12060
tatcccgacg cctgcaagcg cagcccgtgc cagcacgggg gcagctgcac tggcctgcca
12120 tcggggggct atcagtgtac ctgtctctca cagtttacgg ggagaaactg
tgaatctgag 12180 attacagcct gcttcccaaa cccctgccgg aatggaggat
cctgcgatcc aataggaaac 12240 actttcatct gcaattgtaa agctgggctc
actggagtca cgtgtgagga ggacatcaat 12300 gagtgcgaac gagaggagtg
tgagaacgga ggctcctgcg tgaacgtgtt cggctccttc 12360 ctctgcaact
gcacgccggg ctacgtgggc cagtactgcg ggctgcgccc cgtggtggta 12420
cccaatatcc aggctggcca ctcctacgtg gggaaggagg agctcatcgg catcgccgtg
12480 gtcctcttcg tcatcttcat cctggtggtt ctcttcatag tcttccgcaa
gaaggtcttc 12540 cgcaagaact actcccgcaa caacatcacg ctagtgcagg
acccggccac cgccgccctg 12600 cttaacaaga gcaatggcat cccgttccgg
aacctgcgcg gcagtgggga cggccgcaac 12660 gtctaccagg aggtggggcc
cccgcaggtc cccgtgcgcc ccatggccta cacaccctgc 12720 ttccagagtg
actccaggag caacctggat aagatcgtgg acgggctggg aggcgagcac 12780
caggaaatga ccacgtttca ccctgagtcg ccccgcatcc tgacagcccg gcggggcgtg
12840 gtcgtgtgca gtgtggcccc caacctcccc gccgtgtcac cctgccgctc
cgactgcgac 12900 tccatccgga agaatggctg ggacgcggga actgagaaca
aaggggttga tgacccggga 12960 gaagtgacct gctttgcagg tagtaataaa
ggcagcaact ctgaagttca gtccctcagc 13020 tccttccagt cagattctgg
tgacgacaat gcctccatag tgactgtcat tcagcttgtc 13080 aacaatgtag
ttgacactat agagaatgaa gtgtctgtca tggaccaagg acagaactac 13140
aaccgagcct atcactggga cacctctgat tggatgccag gggcccgcct gtcggacata
13200 gaggaagtgc ccaactatga gaaccaggat ggagggtctg cacaccaggg
gagcacacgg 13260 gagctggaga gcgattacta cctgggtggt tatgacattg
acagtgaata cccaccccct 13320 catgaagagg agttcttgag tcaggaccag
ctgcctcctc ctctcccgga ggacttccca 13380 gaccaatatg aggccctgcc
accctcccag cctgtctccc tggccagcac actgagccca 13440 gactgcagga
gaaggcccca gtttcatcct agccagtatc tccctcctca cccattcccc 13500
aacgaaacgg atttggtggg cccgcctgcc agctgtgaat ttagtacttt tgctgtgagc
13560 atgaaccagg gcacagagcc cacaggccca gcagacagcg tgtctctgtc
cttgcacaat 13620 tccagaggca cctcatcctc ggatgtgtct gccaactgcg
gctttgacga ttccgaagta 13680 gccatgagtg actacgagag cgtgggagag
ctcagcctcg ccagccttca cattcccttt 13740 gtggagactc agcatcagac
tcaagtgtag 13770 2 4589 PRT homo sapiens 2 Met Asp Ile Ile Met Gly
His Cys Val Gly Thr Arg Pro Pro Ala Cys 1 5 10 15 Cys Leu Ile Leu
Leu Leu Phe Lys Leu Leu Ala Thr Val Ser Gln Gly 20 25 30 Leu Pro
Gly Thr Gly Pro Leu Gly Phe His Phe Thr His Ser Ile Tyr 35 40 45
Asn Ala Thr Val Tyr Glu Asn Ser Ala Ala Arg Thr Tyr Val Asn Ser 50
55 60 Gln Ser Arg Met Gly Ile Thr Leu Ile Asp Leu Ser Trp Asp Ile
Lys 65 70 75 80 Tyr Arg Ile Val Ser Gly Asp Glu Glu Gly Phe Phe Lys
Ala Glu Glu 85 90 95 Val Ile Ile Ala Asp Phe Cys Phe Leu Arg Ile
Arg Thr Lys Gly Gly 100 105 110 Asn Ser Ala Ile Leu Asn Arg Glu Ile
Gln Asp Asn Tyr Leu Leu Ile 115 120 125 Val Lys Gly Ser Val Arg Gly
Glu Asp Leu Glu Ala Trp Thr Lys Val 130 135 140 Asn Ile Gln Val Leu
Asp Met Asn Asp Leu Arg Pro Leu Phe Ser Pro 145 150 155 160 Thr Thr
Tyr Ser Val Thr Ile Ala Glu Ser Thr Pro Leu Arg Thr Ser 165 170 175
Val Ala Gln Val Thr Ala Thr Asp Ala Asp Ile Gly Ser Asn Gly Glu 180
185 190 Phe Tyr Tyr Tyr Phe Lys Asn Lys Val Asp Leu
Phe Ser Val His Pro 195 200 205 Thr Ser Gly Val Ile Ser Leu Ser Gly
Arg Leu Asn Tyr Asp Glu Lys 210 215 220 Asn Arg Tyr Asp Leu Glu Ile
Leu Ala Val Asp Arg Gly Met Lys Leu 225 230 235 240 Tyr Gly Asn Asn
Gly Val Ser Ser Thr Ala Lys Leu Tyr Val His Ile 245 250 255 Glu Arg
Ile Asn Glu His Ala Pro Thr Ile His Val Val Thr His Val 260 265 270
Pro Phe Ser Leu Glu Lys Glu Pro Thr Tyr Ala Val Val Thr Val Asp 275
280 285 Asp Leu Asp Asp Gly Ala Asn Gly Glu Ile Glu Ser Val Ser Ile
Val 290 295 300 Ala Gly Asp Pro Leu Asp Gln Phe Phe Leu Ala Lys Glu
Gly Lys Trp 305 310 315 320 Leu Asn Glu Tyr Lys Ile Lys Glu Arg Lys
Gln Ile Asp Trp Glu Ser 325 330 335 Phe Pro Tyr Gly Tyr Asn Leu Thr
Leu Gln Ala Lys Asp Lys Gly Ser 340 345 350 Pro Gln Lys Cys Ser Ala
Leu Lys Ala Val Tyr Ile Gly Asn Pro Thr 355 360 365 Arg Asp Thr Val
Pro Ile Arg Phe Glu Lys Glu Val Tyr Asp Val Ser 370 375 380 Ile Ser
Glu Phe Ser Pro Pro Gly Val Val Val Ala Ile Val Lys Leu 385 390 395
400 Ser Pro Glu Pro Ile Asp Val Glu Tyr Lys Leu Ser Pro Gly Glu Asp
405 410 415 Ala Val Tyr Phe Lys Ile Asn Pro Arg Ser Gly Leu Ile Val
Thr Ala 420 425 430 Arg Pro Leu Asn Thr Val Lys Lys Glu Val Tyr Lys
Leu Glu Val Thr 435 440 445 Asn Lys Glu Gly Asp Leu Lys Ala Gln Val
Thr Ile Ser Ile Glu Asp 450 455 460 Ala Asn Asp His Thr Pro Glu Phe
Gln Gln Pro Leu Tyr Asp Ala Tyr 465 470 475 480 Val Asn Glu Ser Val
Pro Val Gly Thr Ser Val Leu Thr Val Ser Ala 485 490 495 Ser Asp Lys
Asp Lys Gly Glu Asn Gly Tyr Ile Thr Tyr Ser Ile Ala 500 505 510 Ser
Leu Asn Leu Leu Pro Phe Val Ile Asn Gln Phe Thr Gly Val Ile 515 520
525 Ser Thr Thr Glu Glu Leu Asp Phe Glu Ser Ser Pro Glu Ile Tyr Arg
530 535 540 Phe Ile Val Arg Ala Ser Asp Trp Gly Ser Pro Tyr Arg His
Glu Ser 545 550 555 560 Glu Val Asn Val Thr Ile Arg Ile Gly Asn Val
Asn Asp Asn Ser Pro 565 570 575 Leu Phe Glu Lys Val Ala Cys Gln Gly
Val Ile Ser Tyr Asp Phe Pro 580 585 590 Val Gly Gly His Ile Thr Ala
Val Ser Ala Ile Asp Ile Asp Glu Leu 595 600 605 Glu Leu Val Lys Tyr
Lys Ile Ile Ser Gly Asn Glu Leu Gly Phe Phe 610 615 620 Tyr Leu Asn
Pro Asp Ser Gly Val Leu Gln Leu Lys Lys Ser Leu Thr 625 630 635 640
Asn Ser Gly Ile Lys Asn Gly Asn Phe Ala Leu Arg Ile Thr Ala Thr 645
650 655 Asp Gly Glu Asn Leu Ala Asp Pro Met Ser Ile Asn Ile Ser Val
Leu 660 665 670 His Gly Lys Val Ser Ser Lys Ser Phe Ser Cys Arg Glu
Thr Arg Val 675 680 685 Ala Gln Lys Leu Ala Glu Lys Leu Leu Ile Lys
Ala Lys Ala Asn Gly 690 695 700 Lys Leu Asn Leu Glu Asp Gly Phe Leu
Asp Phe Tyr Ser Ile Asn Arg 705 710 715 720 Gln Gly Pro Tyr Phe Asp
Lys Ser Phe Pro Ser Asp Val Ala Val Lys 725 730 735 Glu Asp Leu Pro
Val Gly Ala Asn Ile Leu Lys Ile Lys Ala Tyr Asp 740 745 750 Ala Asp
Ser Gly Phe Asn Gly Lys Val Leu Phe Thr Ile Ser Asp Gly 755 760 765
Asn Thr Asp Ser Cys Phe Asn Ile Asp Met Glu Thr Gly Gln Leu Lys 770
775 780 Val Leu Met Pro Met Asp Arg Glu His Thr Asp Leu Tyr Leu Leu
Asn 785 790 795 800 Ile Thr Ile Tyr Asp Leu Gly Asn Pro Gln Lys Ser
Ser Trp Arg Leu 805 810 815 Leu Thr Ile Asn Val Glu Asp Ala Asn Asp
Asn Ser Pro Val Phe Ile 820 825 830 Gln Asp Ser Tyr Ser Val Asn Ile
Leu Glu Ser Ser Gly Ile Gly Thr 835 840 845 Glu Ile Ile Gln Val Glu
Ala Arg Asp Lys Asp Leu Gly Ser Asn Gly 850 855 860 Glu Val Thr Tyr
Ser Val Leu Thr Asp Thr Gln Gln Phe Ala Ile Asn 865 870 875 880 Ser
Ser Thr Gly Ile Val Tyr Val Ala Asp Gln Leu Asp Arg Glu Ser 885 890
895 Lys Ala Asn Tyr Ser Leu Lys Ile Glu Ala Arg Asp Lys Ala Glu Ser
900 905 910 Gly Gln Gln Leu Phe Ser Val Val Thr Leu Lys Val Phe Leu
Asp Asp 915 920 925 Val Asn Asp Cys Ser Pro Ala Phe Ile Pro Ser Ser
Tyr Ser Val Lys 930 935 940 Val Leu Glu Asp Leu Pro Val Gly Thr Val
Ile Ala Trp Leu Glu Thr 945 950 955 960 His Asp Pro Asp Leu Gly Leu
Gly Gly Gln Val Arg Tyr Ser Leu Val 965 970 975 Asn Asp Tyr Asn Gly
Arg Phe Glu Ile Asp Lys Ala Ser Gly Ala Ile 980 985 990 Arg Leu Ser
Lys Glu Leu Asp Tyr Glu Lys Gln Gln Phe Tyr Asn Leu 995 1000 1005
Thr Val Arg Ala Lys Asp Lys Gly Arg Pro Val Ser Leu Ser Ser Val
1010 1015 1020 Ser Phe Val Glu Val Glu Val Val Asp Val Asn Glu Asn
Leu His Thr 1025 1030 1035 1040 Pro Tyr Phe Pro Asp Phe Ala Val Val
Gly Ser Val Lys Glu Asn Ser 1045 1050 1055 Arg Ile Gly Thr Ser Val
Leu Gln Val Thr Ala Arg Asp Glu Asp Ser 1060 1065 1070 Gly Arg Asp
Gly Glu Ile Gln Tyr Ser Ile Arg Asp Gly Ser Gly Leu 1075 1080 1085
Gly Arg Phe Ser Ile Asp Asp Glu Ser Gly Val Ile Thr Ala Ala Asp
1090 1095 1100 Ile Leu Asp Arg Glu Thr Met Gly Ser Tyr Trp Leu Thr
Val Tyr Ala 1105 1110 1115 1120 Thr Asp Arg Gly Val Val Pro Leu Tyr
Ser Thr Ile Glu Val Tyr Ile 1125 1130 1135 Glu Val Glu Asp Val Asn
Asp Asn Ala Pro Leu Thr Ser Glu Pro Ile 1140 1145 1150 Tyr Tyr Pro
Val Val Met Glu Asn Ser Pro Lys Asp Val Ser Val Ile 1155 1160 1165
Gln Ile Gln Ala Glu Asp Pro Asp Ser Ser Ser Asn Glu Lys Leu Thr
1170 1175 1180 Tyr Arg Ile Thr Ser Gly Asn Pro Gln Asn Phe Phe Ala
Ile Asn Ile 1185 1190 1195 1200 Lys Thr Gly Leu Ile Thr Thr Thr Ser
Arg Lys Leu Asp Arg Glu Gln 1205 1210 1215 Gln Ala Glu His Phe Leu
Glu Val Thr Val Thr Asp Gly Gly Pro Ser 1220 1225 1230 Pro Lys Gln
Ser Thr Ile Trp Val Val Val Gln Val Leu Asp Glu Asn 1235 1240 1245
Asp Asn Lys Pro Gln Phe Pro Glu Lys Val Tyr Gln Ile Lys Leu Pro
1250 1255 1260 Glu Arg Asp Arg Lys Lys Arg Gly Glu Pro Ile Tyr Arg
Ala Phe Ala 1265 1270 1275 1280 Phe Asp Arg Asp Glu Gly Pro Asn Ala
Glu Ile Ser Tyr Ser Ile Val 1285 1290 1295 Asp Gly Asn Asp Asp Gly
Lys Phe Phe Ile Asp Pro Lys Thr Gly Met 1300 1305 1310 Val Ser Ser
Arg Lys Gln Phe Thr Ala Gly Ser Tyr Asp Ile Leu Thr 1315 1320 1325
Ile Lys Ala Val Asp Asn Gly Arg Pro Gln Lys Ser Ser Thr Ala Arg
1330 1335 1340 Leu His Ile Glu Trp Ile Lys Lys Pro Pro Pro Ser Pro
Ile Pro Leu 1345 1350 1355 1360 Thr Phe Asp Glu Pro Phe Tyr Asn Phe
Thr Val Met Glu Ser Asp Arg 1365 1370 1375 Val Thr Glu Ile Val Gly
Val Val Ser Val Gln Pro Ala Asn Thr Pro 1380 1385 1390 Leu Trp Phe
Asp Ile Val Gly Gly Asn Phe Asp Ser Ala Phe Asp Ala 1395 1400 1405
Glu Lys Gly Val Gly Thr Ile Val Ile Ala Lys Pro Leu Asp Ala Glu
1410 1415 1420 Gln Arg Ser Ile Tyr Asn Met Ser Val Glu Val Thr Asp
Gly Thr Asn 1425 1430 1435 1440 Val Ala Val Thr Gln Val Phe Ile Lys
Val Leu Asp Asn Asn Asp Asn 1445 1450 1455 Gly Pro Glu Phe Ser Gln
Pro Asn Tyr Asp Val Thr Ile Ser Glu Asp 1460 1465 1470 Val Leu Pro
Asp Thr Glu Ile Leu Gln Ile Glu Ala Thr Asp Arg Asp 1475 1480 1485
Glu Lys His Lys Leu Ser Tyr Thr Val His Ser Ser Ile Asp Ser Ile
1490 1495 1500 Ser Met Arg Lys Phe Arg Ile Asp Pro Ser Thr Gly Val
Leu Tyr Thr 1505 1510 1515 1520 Ala Glu Arg Leu Asp His Glu Ala Gln
Asp Lys His Ile Leu Asn Ile 1525 1530 1535 Met Val Arg Asp Gln Glu
Phe Pro Tyr Arg Arg Asn Leu Ala Arg Val 1540 1545 1550 Ile Val Asn
Val Glu Asp Ala Asn Asp His Ser Pro Tyr Phe Thr Asn 1555 1560 1565
Pro Leu Tyr Glu Ala Ser Val Phe Glu Ser Ala Ala Leu Gly Ser Ala
1570 1575 1580 Val Leu Gln Val Thr Ala Leu Asp Lys Asp Lys Gly Glu
Asn Ala Glu 1585 1590 1595 1600 Leu Ile Tyr Thr Ile Glu Ala Gly Asn
Thr Gly Asn Met Phe Lys Ile 1605 1610 1615 Glu Pro Val Leu Gly Ile
Ile Thr Ile Cys Lys Glu Pro Asp Met Thr 1620 1625 1630 Thr Met Gly
Gln Phe Val Leu Ser Ile Lys Val Thr Asp Gln Gly Ser 1635 1640 1645
Pro Pro Met Ser Ala Thr Ala Ile Val Arg Ile Ser Val Thr Met Ser
1650 1655 1660 Asp Asn Ser His Pro Lys Phe Ile His Lys Asp Tyr Gln
Ala Glu Val 1665 1670 1675 1680 Asn Glu Asn Val Asp Ile Gly Thr Ser
Val Ile Leu Ile Ser Ala Ile 1685 1690 1695 Ser Gln Ser Thr Leu Ile
Tyr Glu Val Lys Asp Gly Asp Ile Asn Gly 1700 1705 1710 Ile Phe Thr
Ile Asn Pro Tyr Ser Gly Val Ile Thr Thr Gln Lys Ala 1715 1720 1725
Leu Asp Tyr Glu Arg Thr Ser Ser Tyr Gln Leu Ile Ile Gln Ala Thr
1730 1735 1740 Asn Met Ala Gly Met Ala Ser Asn Ala Thr Val Asn Ile
Gln Ile Val 1745 1750 1755 1760 Asp Glu Asn Asp Asn Ala Pro Val Phe
Leu Phe Ser Gln Tyr Ser Gly 1765 1770 1775 Ser Leu Ser Glu Ala Ala
Pro Ile Asn Ser Ile Val Arg Ser Leu Asp 1780 1785 1790 Asn Ser Pro
Leu Val Ile Arg Ala Thr Asp Ala Asp Ser Asn Arg Asn 1795 1800 1805
Ala Leu Leu Val Tyr Gln Ile Val Glu Ser Thr Ala Lys Lys Phe Phe
1810 1815 1820 Thr Val Asp Ser Ser Thr Gly Ala Ile Arg Thr Ile Ala
Asn Leu Asp 1825 1830 1835 1840 His Glu Thr Ile Ala His Phe His Phe
His Val His Val Arg Asp Ser 1845 1850 1855 Gly Ser Pro Gln Leu Thr
Ala Glu Ser Pro Val Glu Val Asn Ile Glu 1860 1865 1870 Val Thr Asp
Val Asn Asp Asn Pro Pro Val Phe Thr Gln Ala Val Phe 1875 1880 1885
Glu Thr Ile Leu Leu Leu Pro Thr Tyr Val Gly Val Glu Val Leu Lys
1890 1895 1900 Val Ser Ala Thr Asp Pro Asp Ser Glu Val Pro Pro Glu
Leu Thr Tyr 1905 1910 1915 1920 Ser Leu Met Glu Gly Ser Leu Asp His
Phe Leu Ile Asp Ser Asn Ser 1925 1930 1935 Gly Val Leu Thr Ile Lys
Asn Asn Asn Leu Ser Lys Asp His Tyr Met 1940 1945 1950 Leu Ile Val
Lys Val Ser Asp Gly Lys Phe Tyr Ser Thr Ser Met Val 1955 1960 1965
Thr Ile Met Val Lys Glu Ala Met Asp Ser Gly Leu His Phe Thr Gln
1970 1975 1980 Ser Phe Tyr Ser Thr Ser Ile Ser Glu Asn Asn Thr Asn
Ile Thr Lys 1985 1990 1995 2000 Val Ala Ile Val Asn Ala Val Gly Asn
Arg Leu Asn Glu Pro Leu Lys 2005 2010 2015 Tyr Ser Ile Leu Asn Pro
Gly Asn Lys Phe Lys Ile Lys Ser Thr Ser 2020 2025 2030 Gly Val Ile
Gln Thr Thr Gly Val Pro Phe Asp Arg Glu Glu Gln Glu 2035 2040 2045
Leu Tyr Glu Leu Val Val Glu Ala Ser Arg Glu Leu Asp His Leu Arg
2050 2055 2060 Val Ala Arg Val Val Val Arg Val Asn Ile Glu Asp Ile
Asn Asp Asn 2065 2070 2075 2080 Ser Pro Val Phe Val Gly Leu Pro Tyr
Tyr Ala Ala Val Gln Val Asp 2085 2090 2095 Ala Glu Pro Gly Thr Leu
Ile Tyr Gln Val Thr Ala Ile Asp Lys Asp 2100 2105 2110 Lys Gly Pro
Asn Gly Glu Val Thr Tyr Val Leu Gln Asp Asp Tyr Gly 2115 2120 2125
His Phe Glu Ile Asn Pro Asn Ser Gly Asn Val Ile Leu Lys Glu Ala
2130 2135 2140 Phe Asn Ser Asp Leu Ser Asn Ile Glu Tyr Gly Val Thr
Ile Leu Ala 2145 2150 2155 2160 Lys Asp Gly Gly Lys Pro Ser Leu Ser
Thr Ser Val Glu Leu Pro Ile 2165 2170 2175 Thr Ile Val Asn Lys Ala
Met Pro Val Phe Asp Lys Pro Phe Tyr Thr 2180 2185 2190 Ala Ser Val
Asn Glu Asp Ile Arg Met Asn Thr Pro Ile Leu Ser Ile 2195 2200 2205
Asn Ala Thr Ser Pro Glu Gly Gln Gly Ile Ile Tyr Ile Ile Ile Asp
2210 2215 2220 Gly Asp Pro Phe Lys Gln Phe Asn Ile Asp Phe Asp Thr
Gly Val Leu 2225 2230 2235 2240 Lys Val Val Ser Pro Leu Asp Tyr Glu
Val Thr Ser Ala Tyr Lys Leu 2245 2250 2255 Thr Ile Arg Ala Ser Asp
Ala Leu Thr Gly Ala Arg Ala Glu Val Thr 2260 2265 2270 Val Asp Leu
Leu Val Asn Asp Val Asn Asp Asn Pro Pro Ile Phe Asp 2275 2280 2285
Gln Pro Thr Tyr Asn Thr Thr Leu Ser Glu Ala Ser Leu Ile Gly Thr
2290 2295 2300 Pro Val Leu Gln Val Val Ser Ile Asp Ala Asp Ser Glu
Asn Asn Lys 2305 2310 2315 2320 Met Val His Tyr Gln Ile Val Gln Asp
Thr Tyr Asn Ser Thr Asp Tyr 2325 2330 2335 Phe His Ile Asp Ser Ser
Ser Gly Leu Ile Leu Thr Ala Arg Met Leu 2340 2345 2350 Asp His Glu
Leu Val Gln His Cys Thr Leu Lys Val Arg Ser Ile Asp 2355 2360 2365
Ser Gly Phe Pro Ser Leu Ser Ser Glu Val Leu Val His Ile Tyr Ile
2370 2375 2380 Ser Asp Val Asn Asp Asn Pro Pro Val Phe Asn Gln Leu
Ile Tyr Glu 2385 2390 2395 2400 Ser Tyr Val Ser Glu Leu Ala Pro Arg
Gly His Phe Val Thr Cys Val 2405 2410 2415 Gln Ala Ser Asp Ala Asp
Ser Ser Asp Phe Asp Arg Leu Glu Tyr Ser 2420 2425 2430 Ile Leu Ser
Gly Asn Asp Arg Thr Ser Phe Leu Met Asp Ser Lys Ser 2435 2440 2445
Gly Val Ile Thr Leu Ser Asn His Arg Lys Gln Arg Met Glu Pro Leu
2450 2455 2460 Tyr Ser Leu Asn Val Ser Val Ser Asp Gly Leu Phe Thr
Ser Thr Ala 2465 2470 2475 2480 Gln Val His Ile Arg Val Leu Gly Ala
Asn Leu Tyr Ser Pro Ala Phe 2485 2490 2495 Ser Gln Ser Thr Tyr Val
Ala Glu Val Arg Glu Asn Val Ala Ala Gly 2500 2505 2510 Thr Lys Val
Ile His Val Arg Ala Thr Asp Gly Asp Pro Gly Thr Tyr 2515 2520 2525
Gly Gln Ile Ser Tyr Ala Ile Ile Asn Asp Phe Ala Lys Asp Arg Phe
2530 2535 2540 Leu Ile Asp Ser Asn Gly Gln Val Ile Thr Thr Glu Arg
Leu Asp Arg 2545 2550 2555 2560 Glu Asn Pro Leu Glu Gly Asp Val Ser
Ile Phe Val Arg Ala Leu Asp 2565 2570 2575 Gly Gly Gly Arg Thr Thr
Phe Cys Thr Val Arg Val Ile Val Val Asp 2580 2585 2590 Glu Asn Asp
Asn Ala Pro Gln Phe Met Thr Val Glu Tyr Arg Ala Ser 2595 2600 2605
Val Arg Ala Asp Val Gly Arg Gly His Leu Val Thr Gln Val Gln Ala
2610 2615
2620 Ile Asp Pro Asp Asp Gly Ala Asn Ser Arg Ile Thr Tyr Ser Leu
Tyr 2625 2630 2635 2640 Ser Glu Ala Ser Val Ser Val Ala Asp Leu Leu
Glu Ile Asp Pro Asp 2645 2650 2655 Asn Gly Trp Met Val Thr Lys Gly
Asn Phe Asn Gln Leu Lys Asn Thr 2660 2665 2670 Val Leu Ser Phe Phe
Val Lys Ala Val Asp Gly Gly Ile Pro Val Lys 2675 2680 2685 His Ser
Leu Ile Pro Val Tyr Ile His Val Leu Pro Pro Glu Thr Phe 2690 2695
2700 Leu Pro Ser Phe Thr Gln Ser Gln Tyr Ser Phe Thr Ile Ala Glu
Asp 2705 2710 2715 2720 Thr Ala Ile Gly Ser Thr Val Asp Thr Leu Arg
Ile Leu Pro Ser Gln 2725 2730 2735 Asn Val Trp Phe Ser Thr Val Asn
Gly Glu Arg Pro Glu Asn Asn Lys 2740 2745 2750 Gly Gly Val Phe Val
Ile Glu Gln Glu Thr Gly Thr Ile Lys Leu Asp 2755 2760 2765 Lys Arg
Leu Asp Arg Glu Thr Ser Pro Ala Phe His Phe Lys Val Ala 2770 2775
2780 Ala Thr Ile Pro Leu Asp Lys Val Asp Ile Val Phe Thr Val Asp
Val 2785 2790 2795 2800 Asp Ile Lys Val Leu Asp Leu Asn Asp Asn Lys
Pro Val Phe Glu Thr 2805 2810 2815 Ser Ser Tyr Asp Thr Ile Ile Met
Glu Gly Met Pro Val Gly Thr Lys 2820 2825 2830 Leu Thr Gln Val Arg
Ala Ile Asp Met Asp Trp Gly Ala Asn Gly Gln 2835 2840 2845 Val Thr
Tyr Ser Leu His Ser Asp Ser Gln Pro Glu Lys Val Met Glu 2850 2855
2860 Ala Phe Asn Ile Asp Ser Asn Thr Gly Trp Ile Ser Thr Leu Lys
Asp 2865 2870 2875 2880 Leu Asp His Glu Thr Asp Pro Thr Phe Thr Phe
Ser Val Val Ala Ser 2885 2890 2895 Asp Leu Gly Glu Ala Phe Ser Leu
Ser Ser Thr Ala Leu Val Ser Val 2900 2905 2910 Arg Val Thr Asp Ile
Asn Asp Asn Ala Pro Val Phe Ala Gln Glu Val 2915 2920 2925 Tyr Arg
Gly Asn Val Lys Glu Ser Asp Pro Pro Gly Glu Val Val Ala 2930 2935
2940 Val Leu Ser Thr Trp Asp Arg Asp Thr Ser Asp Val Asn Arg Gln
Val 2945 2950 2955 2960 Ser Tyr His Ile Thr Gly Gly Asn Pro Arg Gly
Arg Phe Ala Leu Gly 2965 2970 2975 Leu Val Gln Ser Glu Trp Lys Val
Tyr Val Lys Arg Pro Leu Asp Arg 2980 2985 2990 Glu Glu Gln Asp Ile
Tyr Phe Leu Asn Ile Thr Ala Thr Asp Gly Leu 2995 3000 3005 Phe Val
Thr Gln Ala Met Val Glu Val Ser Val Ser Asp Val Asn Asp 3010 3015
3020 Asn Ser Pro Val Cys Asp Gln Val Ala Tyr Thr Ala Leu Leu Pro
Glu 3025 3030 3035 3040 Asp Ile Pro Ser Asn Lys Ile Ile Leu Lys Val
Ser Ala Lys Asp Ala 3045 3050 3055 Asp Ile Gly Ser Asn Gly Tyr Ile
Arg Tyr Ser Leu Tyr Gly Ser Gly 3060 3065 3070 Asn Ser Glu Phe Phe
Leu Asp Pro Glu Ser Gly Glu Leu Lys Thr Leu 3075 3080 3085 Ala Leu
Leu Asp Arg Glu Arg Ile Pro Val Tyr Ser Leu Met Ala Lys 3090 3095
3100 Ala Thr Asp Gly Gly Gly Arg Phe Cys Gln Ser Asn Ile His Leu
Ile 3105 3110 3115 3120 Leu Glu Asp Val Asn Asp Asn Pro Pro Val Phe
Ser Ser Asp His Tyr 3125 3130 3135 Asn Thr Cys Val Tyr Glu Asn Thr
Ala Thr Lys Ala Leu Leu Thr Arg 3140 3145 3150 Val Gln Ala Val Asp
Pro Asp Ile Gly Ile Asn Arg Lys Val Val Tyr 3155 3160 3165 Ser Leu
Ala Asp Ser Ala Gly Gly Val Phe Ser Ile Asp Ser Ser Ser 3170 3175
3180 Gly Ile Ile Ile Leu Glu Gln Pro Leu Asp Arg Glu Gln Gln Ser
Ser 3185 3190 3195 3200 Tyr Asn Ile Ser Val Arg Ala Thr Asp Gln Ser
Pro Gly Gln Ser Leu 3205 3210 3215 Ser Ser Leu Thr Thr Val Thr Ile
Thr Val Leu Asp Ile Asn Asp Asn 3220 3225 3230 Pro Pro Val Phe Glu
Arg Arg Asp Tyr Leu Val Thr Val Pro Glu Asp 3235 3240 3245 Thr Ser
Pro Gly Thr Gln Val Leu Ala Val Phe Ala Thr Ser Lys Asp 3250 3255
3260 Ile Gly Thr Asn Ala Glu Ile Thr Tyr Leu Ile Arg Ser Gly Asn
Glu 3265 3270 3275 3280 Gln Gly Lys Phe Lys Ile Asn Pro Lys Thr Gly
Gly Ile Ser Val Ser 3285 3290 3295 Glu Val Leu Asp Tyr Glu Leu Cys
Lys Arg Phe Tyr Leu Val Val Glu 3300 3305 3310 Ala Lys Asp Gly Gly
Thr Pro Ala Leu Ser Ala Val Ala Thr Val Asn 3315 3320 3325 Ile Asn
Leu Thr Asp Val Asn Asp Asn Pro Pro Lys Phe Ser Gln Asp 3330 3335
3340 Val Tyr Ser Ala Val Ile Ser Glu Asp Ala Leu Val Gly Asp Ser
Val 3345 3350 3355 3360 Ile Leu Leu Ile Ala Glu Asp Val Asp Ser Gln
Pro Asn Gly Gln Ile 3365 3370 3375 His Phe Ser Ile Val Asn Gly Asp
Arg Asp Asn Glu Phe Thr Val Asp 3380 3385 3390 Pro Val Leu Gly Leu
Val Lys Val Lys Lys Lys Leu Asp Arg Glu Arg 3395 3400 3405 Val Ser
Gly Tyr Ser Leu Leu Val Gln Ala Val Asp Ser Gly Ile Pro 3410 3415
3420 Ala Met Ser Ser Thr Ala Thr Val Asn Ile Asp Ile Ser Asp Val
Asn 3425 3430 3435 3440 Asp Asn Ser Pro Val Phe Thr Pro Ala Asn Tyr
Thr Ala Val Ile Gln 3445 3450 3455 Glu Asn Lys Pro Val Gly Thr Ser
Ile Leu Gln Leu Val Val Thr Asp 3460 3465 3470 Arg Asp Ser Phe His
Asn Gly Pro Pro Phe Ser Phe Ser Ile Leu Ser 3475 3480 3485 Gly Asn
Glu Glu Glu Glu Phe Val Leu Asp Pro His Gly Ile Leu Arg 3490 3495
3500 Ser Ala Val Val Phe Gln His Thr Glu Ser Leu Glu Tyr Val Leu
Cys 3505 3510 3515 3520 Val Gln Ala Lys Asp Ser Gly Lys Pro Gln Gln
Val Ser His Thr Tyr 3525 3530 3535 Ile Arg Val Arg Val Ile Glu Glu
Ser Thr His Lys Pro Thr Ala Ile 3540 3545 3550 Pro Leu Glu Ile Phe
Ile Val Thr Met Glu Asp Asp Phe Pro Gly Gly 3555 3560 3565 Val Ile
Gly Lys Ile His Ala Thr Asp Gln Asp Met Tyr Asp Val Leu 3570 3575
3580 Thr Phe Ala Leu Lys Ser Glu Gln Lys Ser Leu Phe Lys Val Asn
Ser 3585 3590 3595 3600 His Asp Gly Lys Ile Ile Ala Leu Gly Gly Leu
Asp Ser Gly Lys Tyr 3605 3610 3615 Val Leu Asn Val Ser Val Ser Asp
Gly Arg Phe Gln Val Pro Ile Asp 3620 3625 3630 Val Val Val His Val
Glu Gln Leu Val His Glu Met Leu Gln Asn Thr 3635 3640 3645 Val Thr
Ile Arg Phe Glu Asn Val Ser Pro Glu Asp Phe Val Gly Leu 3650 3655
3660 His Met His Gly Phe Arg Arg Thr Leu Arg Asn Ala Val Leu Thr
Gln 3665 3670 3675 3680 Lys Gln Asp Ser Leu Arg Ile Ile Ser Ile Gln
Pro Val Ala Gly Thr 3685 3690 3695 Asn Gln Leu Asp Met Leu Phe Ala
Val Glu Met His Ser Ser Glu Phe 3700 3705 3710 Tyr Lys Pro Ala Tyr
Leu Ile Gln Lys Leu Ser Asn Ala Arg Arg His 3715 3720 3725 Leu Glu
Asn Ile Met Arg Ile Ser Ala Ile Leu Glu Lys Asn Cys Ser 3730 3735
3740 Gly Leu Asp Cys Gln Glu Gln His Cys Glu Gln Gly Leu Ser Leu
Asp 3745 3750 3755 3760 Ser His Ala Leu Met Thr Tyr Ser Thr Ala Arg
Ile Ser Phe Val Cys 3765 3770 3775 Pro Arg Phe Tyr Arg Asn Val Arg
Cys Thr Cys Asn Gly Gly Leu Cys 3780 3785 3790 Pro Gly Ser Asn Asp
Pro Cys Val Glu Lys Pro Cys Pro Gly Asp Met 3795 3800 3805 Gln Cys
Val Gly Tyr Glu Ala Ser Arg Arg Pro Phe Leu Cys Gln Cys 3810 3815
3820 Pro Pro Gly Lys Leu Gly Glu Cys Ser Gly His Thr Ser Leu Ser
Phe 3825 3830 3835 3840 Ala Gly Asn Ser Tyr Ile Lys Tyr Arg Leu Ser
Glu Asn Ser Lys Glu 3845 3850 3855 Glu Asp Phe Lys Leu Ala Leu Arg
Leu Arg Thr Leu Gln Ser Asn Gly 3860 3865 3870 Ile Ile Met Tyr Thr
Arg Ala Asn Pro Cys Ile Ile Leu Lys Ile Val 3875 3880 3885 Asp Gly
Lys Leu Trp Phe Gln Leu Asp Cys Gly Ser Gly Pro Gly Ile 3890 3895
3900 Leu Gly Ile Ser Gly Arg Ala Val Asn Asp Gly Ser Trp His Ser
Val 3905 3910 3915 3920 Phe Leu Glu Leu Asn Arg Asn Phe Thr Ser Leu
Ser Leu Asp Asp Ser 3925 3930 3935 Tyr Val Glu Arg Arg Arg Ala Pro
Leu Tyr Phe Gln Thr Leu Ser Thr 3940 3945 3950 Glu Ser Ser Ile Tyr
Phe Gly Ala Leu Val Gln Ala Asp Asn Ile Arg 3955 3960 3965 Ser Leu
Thr Asp Thr Arg Val Thr Gln Val Leu Ser Gly Phe Gln Gly 3970 3975
3980 Cys Leu Asp Ser Val Ile Leu Asn Asn Asn Glu Leu Pro Leu Gln
Asn 3985 3990 3995 4000 Lys Arg Ser Ser Phe Ala Glu Val Val Gly Leu
Thr Glu Leu Lys Leu 4005 4010 4015 Gly Cys Val Leu Tyr Pro Asp Ala
Cys Lys Arg Ser Pro Cys Gln His 4020 4025 4030 Gly Gly Ser Cys Thr
Gly Leu Pro Ser Gly Gly Tyr Gln Cys Thr Cys 4035 4040 4045 Leu Ser
Gln Phe Thr Gly Arg Asn Cys Glu Ser Glu Ile Thr Ala Cys 4050 4055
4060 Phe Pro Asn Pro Cys Arg Asn Gly Gly Ser Cys Asp Pro Ile Gly
Asn 4065 4070 4075 4080 Thr Phe Ile Cys Asn Cys Lys Ala Gly Leu Thr
Gly Val Thr Cys Glu 4085 4090 4095 Glu Asp Ile Asn Glu Cys Glu Arg
Glu Glu Cys Glu Asn Gly Gly Ser 4100 4105 4110 Cys Val Asn Val Phe
Gly Ser Phe Leu Cys Asn Cys Thr Pro Gly Tyr 4115 4120 4125 Val Gly
Gln Tyr Cys Gly Leu Arg Pro Val Val Val Pro Asn Ile Gln 4130 4135
4140 Ala Gly His Ser Tyr Val Gly Lys Glu Glu Leu Ile Gly Ile Ala
Val 4145 4150 4155 4160 Val Leu Phe Val Ile Phe Ile Leu Val Val Leu
Phe Ile Val Phe Arg 4165 4170 4175 Lys Lys Val Phe Arg Lys Asn Tyr
Ser Arg Asn Asn Ile Thr Leu Val 4180 4185 4190 Gln Asp Pro Ala Thr
Ala Ala Leu Leu Asn Lys Ser Asn Gly Ile Pro 4195 4200 4205 Phe Arg
Asn Leu Arg Gly Ser Gly Asp Gly Arg Asn Val Tyr Gln Glu 4210 4215
4220 Val Gly Pro Pro Gln Val Pro Val Arg Pro Met Ala Tyr Thr Pro
Cys 4225 4230 4235 4240 Phe Gln Ser Asp Ser Arg Ser Asn Leu Asp Lys
Ile Val Asp Gly Leu 4245 4250 4255 Gly Gly Glu His Gln Glu Met Thr
Thr Phe His Pro Glu Ser Pro Arg 4260 4265 4270 Ile Leu Thr Ala Arg
Arg Gly Val Val Val Cys Ser Val Ala Pro Asn 4275 4280 4285 Leu Pro
Ala Val Ser Pro Cys Arg Ser Asp Cys Asp Ser Ile Arg Lys 4290 4295
4300 Asn Gly Trp Asp Ala Gly Thr Glu Asn Lys Gly Val Asp Asp Pro
Gly 4305 4310 4315 4320 Glu Val Thr Cys Phe Ala Gly Ser Asn Lys Gly
Ser Asn Ser Glu Val 4325 4330 4335 Gln Ser Leu Ser Ser Phe Gln Ser
Asp Ser Gly Asp Asp Asn Ala Ser 4340 4345 4350 Ile Val Thr Val Ile
Gln Leu Val Asn Asn Val Val Asp Thr Ile Glu 4355 4360 4365 Asn Glu
Val Ser Val Met Asp Gln Gly Gln Asn Tyr Asn Arg Ala Tyr 4370 4375
4380 His Trp Asp Thr Ser Asp Trp Met Pro Gly Ala Arg Leu Ser Asp
Ile 4385 4390 4395 4400 Glu Glu Val Pro Asn Tyr Glu Asn Gln Asp Gly
Gly Ser Ala His Gln 4405 4410 4415 Gly Ser Thr Arg Glu Leu Glu Ser
Asp Tyr Tyr Leu Gly Gly Tyr Asp 4420 4425 4430 Ile Asp Ser Glu Tyr
Pro Pro Pro His Glu Glu Glu Phe Leu Ser Gln 4435 4440 4445 Asp Gln
Leu Pro Pro Pro Leu Pro Glu Asp Phe Pro Asp Gln Tyr Glu 4450 4455
4460 Ala Leu Pro Pro Ser Gln Pro Val Ser Leu Ala Ser Thr Leu Ser
Pro 4465 4470 4475 4480 Asp Cys Arg Arg Arg Pro Gln Phe His Pro Ser
Gln Tyr Leu Pro Pro 4485 4490 4495 His Pro Phe Pro Asn Glu Thr Asp
Leu Val Gly Pro Pro Ala Ser Cys 4500 4505 4510 Glu Phe Ser Thr Phe
Ala Val Ser Met Asn Gln Gly Thr Glu Pro Thr 4515 4520 4525 Gly Pro
Ala Asp Ser Val Ser Leu Ser Leu His Asn Ser Arg Gly Thr 4530 4535
4540 Ser Ser Ser Asp Val Ser Ala Asn Cys Gly Phe Asp Asp Ser Glu
Val 4545 4550 4555 4560 Ala Met Ser Asp Tyr Glu Ser Val Gly Glu Leu
Ser Leu Ala Ser Leu 4565 4570 4575 His Ile Pro Phe Val Glu Thr Gln
His Gln Thr Gln Val 4580 4585 3 11559 DNA homo sapiens 3 atggatataa
ttatgggaca ctgtgtgggc acacggcctc ctgcttgttg cctcatcctc 60
ctgcttttca agcttttggc cactgtctcc caggggctgc cagggactgg acccctgggc
120 ttccacttca cacattccat ttataatgct accgtgtatg agaactcagc
agcaaggacc 180 tacgtcaaca gccagagtag aatgggcatc accttaatag
atctatcctg ggatatcaaa 240 tacagaatag tgtccggaga cgaggaaggc
tttttcaaag cagaggaagt catcattgca 300 gatttctgtt ttctcagaat
aagaactaaa ggtggcaatt ctgccatatt aaatagggaa 360 atccaggata
attatttatt gatagtaaaa ggttctgtca gaggagagga tttggaagca 420
tggaccaaag tgaatataca ggttttagat atgaatgatc tgagaccttt gttttcaccc
480 acaacatact ctgttaccat agcagaaagc acacctctaa ggactagtgt
tgcccaggtg 540 actgcaacag acgcagatat tggttccaat ggagaattct
actactactt taaaaataaa 600 gttgatctct tttcagttca ccccacgagt
ggtgtcatct ccttaagtgg tcgattaaat 660 tatgatgaaa agaataggta
tgatctggaa attttggctg tggaccgggg aatgaaactg 720 tatgggaaca
atggagtgag cagtactgca aagctttatg ttcacattga gcgcataaat 780
gaacatgccc caacaatcca tgtagtcact catgttcctt tctcgttgga aaaagagcca
840 acatatgcag tggtgacagt tgatgactta gatgatggag cgaatggaga
gatcgaatct 900 gtttccattg tggctgggga tcctttagat cagttcttcc
tggctaagga aggaaagtgg 960 ttgaatgagt acaagattaa ggagaggaag
cagattgact gggagagctt tccctatggc 1020 tacaatctca ctcttcaagc
aaaagacaag ggatctcctc aaaaatgttc agcattaaag 1080 gcagtctaca
ttggcaaccc cacaagagac actgtcccca ttagatttga aaaagaagtg 1140
tacgatgtga gcataagtga attttcccct cctggtgtcg tggttgctat agtaaaatta
1200 agtcctgaac cgatagatgt ggaatacaaa ttatctcctg gtgaggatgc
agtgtacttt 1260 aaaattaatc ctcggtcggg tctgattgtt acagcacggc
cactgaatac tgttaagaag 1320 gaggtttata aactggaggt gacaaacaag
gaaggagatt taaaagcaca ggtcaccatc 1380 agcatagaag atgcaaatga
ccacacccca gaatttcagc aaccactgta tgatgcttat 1440 gtgaatgaaa
gtgtcccagt gggaaccagc gttctaacag tttcagcttc tgataaggat 1500
aaaggagaaa atgggtacat cacctatagt atcgctagcc tgaatttgtt accatttgtc
1560 attaatcagt ttacaggtgt tattagcaca actgaagaac tggattttga
atcctcccca 1620 gaaatttaca gattcattgt tagagcctct gactggggtt
caccataccg ccatgaaagt 1680 gaggtcaatg tgactattcg aataggaaat
gtcaacgaca acagccctct ctttgaaaaa 1740 gtggcttgcc agggagttat
ttcatatgac tttccagttg gtggtcacat cacagcagtc 1800 tcagcgatcg
atatcgatga acttgaactt gtaaagtaca aaatcatttc tggaaatgaa 1860
cttggcttct tttatttaaa cccagattct ggtgttttac agcttaaaaa atcactgaca
1920 aattctggca ttaaaaatgg caattttgcc ctcagaatta cagcaactga
tggagagaat 1980 cttgcagacc ccatgtctat taacatttca gtcctacatg
ggaaagtgtc ttcaaagagc 2040 ttcagttgca gagaaactcg tgtggctcaa
aagctggcag agaaactact cattaaggca 2100 aaagcaaatg ggaaactgaa
tctggaagat ggatttcttg acttttattc aattaataga 2160 cagggaccat
attttgacaa gtcttttcct tctgatgtgg ctgtaaagga ggatctgcca 2220
gttggtgcta acattctgaa gattaaagcc tatgatgccg actctggctt caatggaaaa
2280 gtgctattta caatatcaga tggaaatacg gatagttgct ttaatattga
tatggagact 2340 gggcagctta aagtccttat gcccatggat cgagaacaca
cagacctcta tctccttaat 2400 atcaccatct atgacttagg taatccacag
aaatcgtcat ggagactgct gaccatcaat 2460 gtggaggatg ctaatgacaa
tagcccagtt tttattcaag acagttactc agttaacatt 2520 cttgaaagtt
caggcattgg tactgaaatc attcaagtgg aagccagaga caaagactta 2580
ggttctaatg gtgaagtgac ttactcagtc ttgacagata cacagcagtt tgccatcaat
2640 agctcaactg gaatcgttta tgtagccgac cagttggacc gggaatccaa
agccaattat 2700 tctttgaaaa tagaagccag ggacaaggca gagagtggtc
agcagctgtt ttcagttgtc 2760 actcttaaag tttttttaga tgatgtcaat
gactgctccc cagctttcat tcccagtagc 2820 tatagtgtga aggttcttga
agatctccct gttggcactg tcattgcttg gcttgagacc 2880 catgatccag
atcttggact ggggggtcaa gtgcgctatt ctttggtcaa tgactataat 2940
gggagatttg aaatagataa agcaagtggt gccatccgct tgagcaaaga gcttgattat
3000 gagaaacagc agttctataa ccttactgtg cgggccaaag acaaagggcg
gcctgtctct 3060 ctgtcatctg tttcctttgt tgaggtggaa gtggtggatg
tcaatgaaaa cctccacact 3120 ccctatttcc cagactttgc tgttgttgga
tctgtaaagg aaaactcacg cattggaaca 3180 agcgtgctgc aggtgactgc
tcgagatgaa gactccggaa gggatggaga gatccagtac 3240 tccatcaggg
atggcagtgg tcttggaagg ttcagtatag acgacgagag tggggtcatc 3300
actgccgcag acattcttga tcgggagaca atggggtcat actggctaac agtgtatgcc
3360 acagacaggg gcgttgttcc actctactcc accattgagg tctacattga
agttgaagat 3420 gtgaatgaca atgccccgct gacctcagaa cctatatatt
atcctgttgt catggaaaac 3480 tctccaaagg acgtatctgt cattcagatc
caggctgaag atcctgactc cagttccaat 3540 gaaaaactga catacaggat
tacaagtgga aatcctcaga atttttttgc catcaatatc 3600 aaaacaggtc
tgattacaac aacttcaagg aaattggatc gagaacagca ggcagaacat 3660
tttctggagg tgactgtgac agatggtggt ccctctccaa aacagtcaac catttgggtg
3720 gtggttcagg ttctagatga aaatgacaac aagccccagt tcccagagaa
ggtctaccag 3780 atcaagctgc cagaacgtga ccgaaagaag agaggagaac
cgatttacag ggcttttgca 3840 tttgatagag atgagggccc caacgcagaa
atctcctaca gtattgtgga tgggaatgat 3900 gacggaaagt tctttattga
ccctaaaact gggatggttt cttctagaaa gcagtttaca 3960 gcaggcagtt
atgacatcct aacgataaag gcagtggaca atgggcgccc acagaaatcc 4020
tccacggccc gcctccacat tgaatggatt aagaaaccac ccccttcacc tataccattg
4080 accttcgatg agccgtttta taacttcaca gtcatggaaa gtgatagagt
gactgaaatt 4140 gtaggggtgg tgtctgtgca gccagctaac acccctctgt
ggtttgacat agttgggggg 4200 aattttgaca gcgcttttga tgcagagaag
ggtgttggga caattgtcat cgcaaaacct 4260 ttggatgcag agcagaggtc
catctataat atgagtgtgg aagtcaccga tgggacaaat 4320 gttgctgtta
ctcaggtatt tatcaaagtg ctggataata atgataatgg cccagaattc 4380
tctcagccga attacgatgt gacaatttcc gaggatgtgc ttccagacac ggagatcctg
4440 cagattgaag ccacagatag agatgagaag cacaagctga gctacactgt
tcatagcagc 4500 atcgactcca tcagcatgag aaaattccgg attgacccta
gcactggcgt gctctatact 4560 gccgagaggc tggaccatga ggcccaggac
aagcacattc tcaacataat ggtcagagat 4620 caggagtttc cttatcgaag
aaacttggcc cgagtcattg tgaatgtgga ggatgctaat 4680 gatcacagtc
cttattttac caacccactg tatgaagcgt ctgtgtttga atctgctgct 4740
ctgggatcag ctgttctgca agtgacggct ctggacaaag acaaaggaga aaatgcagaa
4800 ctcatatata ccatagaagc agggaacact gggaacatgt ttaagatcga
accggtccta 4860 ggcatcatca ccatttgcaa agaaccagac atgacgacga
tgggtcagtt tgtcctatcc 4920 atcaaagtca cagatcaggg atccccgcca
atgtctgcta ctgcaattgt gcgcatttcc 4980 gtcaccatgt ctgacaattc
tcaccccaag ttcattcaca aagactacca agcagaagta 5040 aatgaaaatg
ttgacattgg aacatcagtc attctaatct ctgccatcag tcaatctacc 5100
ctcatttatg aagtcaaaga tggagacatt aatgggatct ttaccataaa tccatattct
5160 ggagtcatca ccactcagaa ggccctggat tatgagcgca catcctctta
tcaactcatc 5220 attcaggcca ccaatatggc aggaatggct tccaatgcta
cagtcaatat tcagattgtt 5280 gatgaaaatg ataatgcccc agtttttctc
ttttctcaat actcaggcag cctaagtgag 5340 gctgccccaa ttaatagcat
tgtcaggagc ttggataaca gcccactggt gattcgagcc 5400 acagatgctg
acagcaaccg gaatgctctg cttgtgtatc agattgtgga gtcaacagca 5460
aaaaagtttt tcacggtgga ctccagtaca ggtgcaatca gaacaattgc caacctggac
5520 catgaaacca ttgcccattt ccattttcat gtgcatgtga gagacagtgg
tagcccccaa 5580 ctgactgcag agagtcccgt tgaagtcaac attgaggtga
cagatgtgaa tgataaccca 5640 cctgttttta ctcaggctgt gtttgagact
atcttacttc tacctaccta tgttggagtg 5700 gaggttctga aagttagtgc
cacagatcct gactctgagg taccccctga actgacatac 5760 agcctaatgg
aaggcagttt ggatcatttt ttaattgact caaacagtgg agtacttacc 5820
ataaaaaaca acaacctctc caaggatcac tacatgctga tagttaaggt gtctgatgga
5880 aagttctaca gtacctccat ggtcaccatc atggttaaag aagccatgga
cagcggcctc 5940 cactttacac aaagcttcta ttccacctca atctcagaga
acaacactaa cataaccaaa 6000 gttgctattg tcaatgcagt tggaaatcgc
cttaatgagc ccttaaaata cagcatctta 6060 aacccaggaa ataagttcaa
gataaaatct acctcagggg tcattcagac gactggagtc 6120 ccctttgacc
gtgaagaaca agagttatat gagctggtgg tagaagccag ccgtgagctg 6180
gaccatctgc gtgtggccag agtggtggtc agggttaaca ttgaagacat aaatgacaat
6240 tctccagtct ttgtgggcct cccatactat gctgctgttc aagtggatgc
ggaacccggg 6300 actctgattt atcaggtgac agccattgac aaagataaag
gtccaaatgg agaagtgacc 6360 tatgtcctgc aggatgacta tggccacttt
gaaattaacc ctaattcagg gaatgttatt 6420 ttaaaggaag cattcaactc
tgacttgtcc aacattgagt atggagtcac catcctagcc 6480 aaggatggcg
gaaaaccttc tttgtctaca tctgtggagc ttcccatcac tattgtcaac 6540
aaagcaatgc ctgtgtttga taagcccttt tatacagcat ctgtcaatga agacatcaga
6600 atgaacacac ccatcctaag catcaatgcc accagtccag aaggccaagg
catcatatat 6660 atcattatcg atggggaccc ttttaaacag tttaacattg
actttgacac tggggtcctg 6720 aaagttgtta gccctttgga ttatgaagtt
acatctgctt acaagctgac aataagagcc 6780 agcgacgccc ttactggtgc
tagggctgaa gtcactgttg acttgctagt taatgatgta 6840 aatgacaacc
cccctatttt cgatcagcct acatacaata caacactatc agaagcatct 6900
cttattggga cacctgtttt acaagttgtc tctattgatg cagactcaga aaacaataaa
6960 atggtacatt atcagattgt ccaggatacc tacaatagca cagattattt
tcacatagat 7020 agctcaagtg gcttaatcct gacagcacga atgctggacc
atgagttagt acaacactgc 7080 actttgaaag tcagatcaat agatagtggc
ttcccatcac tgagcagtga ggttctcgtt 7140 catatctaca tctctgatgt
aaatgacaac cctccagttt ttaatcagct catttatgag 7200 tcatatgtga
gtgaattagc cccccggggc cattttgtaa cctgtgtaca agcctctgat 7260
gcagacagct ctgattttga ccggttggaa tatagcattt tatctgggaa tgaccggacg
7320 agctttctga tggacagcaa gagtggagtt atcacattgt ccaaccatcg
gaagcagcgg 7380 atggagcctc tgtacagtct caatgtgtct gtctctgatg
ggttgttcac cagcactgca 7440 caggtgcata ttagggtact tggggctaac
ttgtacagcc ctgccttttc acaaagcaca 7500 tacgtagctg aggtgagaga
gaacgtggct gcaggaacaa aggtaattca tgttcgagcc 7560 acagatggtg
atccagggac ttatgggcag atcagctatg ccatcatcaa tgactttgcc 7620
aaggatcgat tcctcataga cagcaatggg caggtcatca ccacagaaag gctagaccgg
7680 gaaaaccctc tagaagggga tgttagtatt tttgtgaggg cccttgatgg
tggagggaga 7740 acaactttct gcactgtgag agtgattgtt gtggatgaaa
atgacaatgc tccccagttc 7800 atgacagtgg aatatagagc cagtgtcagg
gcagatgttg gaaggggcca cttggtcact 7860 caagttcaag ccatagatcc
cgatgatgga gcaaattcaa ggattactta ttccctctat 7920 agcgaggcct
ctgtttcagt ggccgacctc ctggaaatcg atcctgacaa tggctggatg 7980
gtcacaaagg gtaattttaa ccagctgaaa aatacagtgc tttcgttctt tgtcaaagca
8040 gtagatgggg gcatcccagt aaagcactcc ctcattcctg tctatatcca
cgtcttgccc 8100 cctgaaacgt tcttgccatc attcacccag tctcagtatt
cctttaccat tgcagaagat 8160 acagccattg ggagtacagt ggacaccctg
aggattttgc ccagtcagaa tgtctggttc 8220 agcacagtta atggggaacg
gccagaaaat aacaaagggg gcgtattcgt catagaacag 8280 gaaacaggca
ctattaagct tgacaaacgc cttgaccgtg aaaccagccc agctttccac 8340
tttaaagtag cagccactat acccctggac aaagtagaca ttgtgtttac tgtggatgta
8400 gatatcaagg tattggattt gaatgacaac aagccagtct ttgaaacttc
aagctatgac 8460 accattataa tggaagggat gcctgttggc accaaactca
cacaagtgag agctattgat 8520 atggactggg gagccaatgg acaagtcact
tactccctcc actcggattc ccagcccgaa 8580 aaggtaatgg aagcattcaa
tattgacagc aacacgggct ggatcagtac cttgaaggac 8640 ctagatcacg
agacagaccc cacattcacc ttctctgtgg tggcctctga ccttggagag 8700
gcattctctc tttcctccac ggccttggtc tctgtcagag tgacagatat aaatgacaat
8760 gcaccagtct tcgcgcagga agtgtaccga gggaatgtga aggagagcga
cccaccgggc 8820 gaggtggtag ccgtcctcag cacctgggac agagacacat
ccgacgttaa tcgccaagtg 8880 agctaccata ttacaggagg aaaccctcga
ggaaggtttg ctctgggcct ggtgcaaagt 8940 gagtggaagg tctatgtgaa
gaggcctcta gacagagaag aacaggacat ttactttctc 9000 aatatcactg
ccactgatgg gctttttgtc acacaggcca tggtggaagt gagcgtcagt 9060
gatgtgaatg acaatagccc agtgtgtgat caggttgcat atacagcatt acttcctgaa
9120 gacattccat caaataaaat catcctgaaa gtcagtgcaa aggatgctga
tattggatcc 9180 aatggatata tacgatactc actctatgga tctggaaaca
gtgaattttt tctagatcca 9240 gaaagtggcg agttaaaaac cttggctctg
ttggaccggg agaggatccc cgtgtacagc 9300 ctgatggcca aggccactga
cgggggtggc aggttctgcc agtccaacat ccacctaatc 9360 ctggaggatg
tgaatgataa cccccctgtg ttttcttctg accactacaa cacctgtgtc 9420
tatgagaaca cagccaccaa ggctctgttg accagagttc aagccgtgga ccccgacatt
9480 ggcatcaata ggaaggtcgt gtactccctg gcagactcag ctggtggggt
cttctccatt 9540 gacagctcat ctggcatcat catcctggag cagccactgg
accgtgagca gcagtcttcg 9600 tacaacatca gcgtgcgggc cactgaccag
agtcctggac agtccctgtc ctctctcact 9660 actgtcacca tcaccgttct
ggacattaat gacaaccccc ctgtgtttga gaggagggac 9720 tacctggtga
cggtgcctga ggacacctcc cctggcaccc aagtccttgc tgtttttgcc 9780
accagcaaag atattggcac aaatgctgag atcacttatc tcatccggtc tgggaacgaa
9840 caagggaaat ttaagatcaa ccccaagaca gggggtattt ctgtctctga
agtcctggac 9900 tatgaattat gcaaaaggtt ttacctggta gtggaagcca
aagatggggg caccccagct 9960 ctcagcgctg tggccactgt caacatcaac
ctcacagatg ttaatgacaa ccctcccaag 10020 ttcagccaag acgtctacag
tgcggttatc agtgaagacg ccttggtggg agactctgtc 10080 attttgctaa
tagcagaaga tgtagacagc cagcccaacg gacagattca tttttccatt 10140
gtgaatggag atcgggacaa tgaatttact gtagatcctg tcttgggact tgtgaaagtt
10200 aagaagaaat tggaccggga acgggtgtct ggatactctc tgcttgtcca
ggccgtagac 10260 agtggcattc ctgcaatgtc atcaactgca actgtcaaca
ttgatatttc tgatgtgaat 10320 gacaacagcc cggtgtttac acctgccaac
tatactgctg tgattcagga aaataagcca 10380 gtgggcacca gcatcttgca
gctggtggtg acagacagag actcctttca caatgggcct 10440 cccttttcat
tctctatttt gtcgggaaat gaagaggagg agtttgtgtt ggaccctcat 10500
gggatcttgc ggtcggctgt ggtcttccag cacacagagt ctctggaata cgtgttgtgt
10560 gtccaggcaa aggattcagg caaaccccag caagtttctc acacttacat
ccgcgtgcga 10620 gtcattgagg aaagcaccca caagcccaca gccattcccc
tggaaatttt cattgtcacc 10680 atggaggatg actttcctgg tggggtcatt
gggaagattc atgccacaga tcaagacatg 10740 tatgatgtgc tcacatttgc
cctgaaatcg gagcagaaaa gcttatttaa agtgaacagt 10800 cacgatggga
aaatcatcgc cctgggaggc ctggacagcg gcaagtatgt cctgaatgtg 10860
tctgtgagtg atggtcgctt ccaggtaccc attgatgtgg tcgtgcatgt ggagcagttg
10920 gtgcatgaga tgctgcagaa cactgtcacc atccgctttg aaaatgtgtc
ccctgaggac 10980 ttcgtggggc tgcacatgca tgggttccgg cgcaccctgc
ggaatgcagt cctcacccag 11040 aagcaggaca gcctgcgcat catcagcatc
cagcccgtgg caggcaccaa ccaactggac 11100 atgctgtttg cggtggagat
gcacagcagc gagttctaca agccagccta cctgatccag 11160 aagctgtcca
atgctagaag acacctggag aatatcatgc gcatctcagc catcttggag 11220
aagaactgct cagggctgga ctgtcaggaa cagcattgtg agcaaggctt gtcactcgat
11280 tcccacgcgc tcatgaccta cagcacggct cgcatcagct ttgtgtgtcc
gcgtttctac 11340 aggaacgtgc gttgcacctg caatggagga ctgtgtccgg
ggtccaacga tccttgtgtg 11400 gagaagccgt gtccagggga catgcagtgt
gtcggttatg aagccagcag gagaccgttc 11460 ctctgccagt gtccaccagg
gaagctcgga gagtgctcag ggcacacttc tctcagcttt 11520 gctggaaaca
gttacatcaa atatcggctt tctgaatag 11559 4 3852 PRT homo sapiens 4 Met
Asp Ile Ile Met Gly His Cys Val Gly Thr Arg Pro Pro Ala Cys 1 5 10
15 Cys Leu Ile Leu Leu Leu Phe Lys Leu Leu Ala Thr Val Ser Gln Gly
20 25 30 Leu Pro Gly Thr Gly Pro Leu Gly Phe His Phe Thr His Ser
Ile Tyr 35 40 45 Asn Ala Thr Val Tyr Glu Asn Ser Ala Ala Arg Thr
Tyr Val Asn Ser 50 55 60 Gln Ser Arg Met Gly Ile Thr Leu Ile Asp
Leu Ser Trp Asp Ile Lys 65 70 75 80 Tyr Arg Ile Val Ser Gly Asp Glu
Glu Gly Phe Phe Lys Ala Glu Glu 85 90 95 Val Ile Ile Ala Asp Phe
Cys Phe Leu Arg Ile Arg Thr Lys Gly Gly 100 105 110 Asn Ser Ala Ile
Leu Asn Arg Glu Ile Gln Asp Asn Tyr Leu Leu Ile 115 120 125 Val Lys
Gly Ser Val Arg Gly Glu Asp Leu Glu Ala Trp Thr Lys Val 130 135 140
Asn Ile Gln Val Leu Asp Met Asn Asp Leu Arg Pro Leu Phe Ser Pro 145
150 155 160 Thr Thr Tyr Ser Val Thr Ile Ala Glu Ser Thr Pro Leu Arg
Thr Ser 165 170 175 Val Ala Gln Val Thr Ala Thr Asp Ala Asp Ile Gly
Ser Asn Gly Glu 180 185 190 Phe Tyr Tyr Tyr Phe Lys Asn Lys Val Asp
Leu Phe Ser Val His Pro 195 200 205 Thr Ser Gly Val Ile Ser Leu Ser
Gly Arg Leu Asn Tyr Asp Glu Lys 210 215 220 Asn Arg Tyr Asp Leu Glu
Ile Leu Ala Val Asp Arg Gly Met Lys Leu 225 230 235 240 Tyr Gly Asn
Asn Gly Val Ser Ser Thr Ala Lys Leu Tyr Val His Ile 245 250 255 Glu
Arg Ile Asn Glu His Ala Pro Thr Ile His Val Val Thr His Val 260 265
270 Pro Phe Ser Leu Glu Lys Glu Pro Thr Tyr Ala Val Val Thr Val Asp
275 280 285 Asp Leu Asp Asp Gly Ala Asn Gly Glu Ile Glu Ser Val Ser
Ile Val 290 295 300 Ala Gly Asp Pro Leu Asp Gln Phe Phe Leu Ala Lys
Glu Gly Lys Trp 305 310 315 320 Leu Asn Glu Tyr Lys Ile Lys Glu Arg
Lys Gln Ile Asp Trp Glu Ser 325 330 335 Phe Pro Tyr Gly Tyr Asn Leu
Thr Leu Gln Ala Lys Asp Lys Gly Ser 340 345 350 Pro Gln Lys Cys Ser
Ala Leu Lys Ala Val Tyr Ile Gly Asn Pro Thr 355 360 365 Arg Asp Thr
Val Pro Ile Arg Phe Glu Lys Glu Val Tyr Asp Val Ser 370 375 380 Ile
Ser Glu Phe Ser Pro Pro Gly Val Val Val Ala Ile Val Lys Leu 385 390
395 400 Ser Pro Glu Pro Ile Asp Val Glu Tyr Lys Leu Ser Pro Gly Glu
Asp 405 410 415 Ala Val Tyr Phe Lys Ile Asn Pro Arg Ser Gly Leu Ile
Val Thr Ala 420 425 430 Arg Pro Leu Asn Thr Val Lys Lys Glu Val Tyr
Lys Leu Glu Val Thr 435 440 445 Asn Lys Glu Gly Asp Leu Lys Ala Gln
Val Thr Ile Ser Ile Glu Asp 450 455 460 Ala Asn Asp His Thr Pro Glu
Phe Gln Gln Pro Leu Tyr Asp Ala Tyr 465 470 475 480 Val Asn Glu Ser
Val Pro Val Gly Thr Ser Val Leu Thr Val Ser Ala 485 490 495 Ser Asp
Lys Asp Lys Gly Glu Asn Gly Tyr Ile Thr Tyr Ser Ile Ala 500 505 510
Ser Leu Asn Leu Leu Pro Phe Val Ile Asn Gln Phe Thr Gly Val Ile 515
520 525 Ser Thr Thr Glu Glu Leu Asp Phe Glu Ser Ser Pro Glu Ile Tyr
Arg 530 535 540 Phe Ile Val Arg Ala Ser Asp Trp Gly Ser Pro Tyr Arg
His Glu Ser 545 550 555 560 Glu Val Asn Val Thr Ile Arg Ile Gly Asn
Val Asn Asp Asn Ser Pro 565 570 575 Leu Phe Glu Lys Val Ala Cys Gln
Gly Val Ile Ser Tyr Asp Phe Pro 580 585 590 Val Gly Gly His Ile Thr
Ala Val Ser Ala Ile Asp Ile Asp Glu Leu 595 600 605 Glu Leu Val Lys
Tyr Lys Ile Ile Ser Gly Asn Glu Leu Gly Phe Phe 610 615 620 Tyr Leu
Asn Pro Asp Ser Gly Val Leu Gln Leu Lys Lys Ser Leu Thr 625 630 635
640 Asn Ser Gly Ile Lys Asn Gly Asn Phe Ala Leu Arg Ile Thr Ala Thr
645 650 655 Asp Gly Glu Asn Leu Ala Asp Pro Met Ser Ile Asn Ile Ser
Val Leu 660 665 670 His Gly Lys Val Ser Ser Lys Ser Phe Ser Cys Arg
Glu Thr Arg Val 675 680 685 Ala Gln Lys Leu Ala Glu Lys Leu Leu Ile
Lys Ala Lys Ala Asn Gly 690 695 700 Lys Leu Asn Leu Glu Asp Gly Phe
Leu Asp Phe Tyr Ser Ile Asn Arg 705 710 715 720 Gln Gly Pro Tyr Phe
Asp Lys Ser Phe Pro Ser Asp Val Ala Val Lys 725 730 735 Glu Asp Leu
Pro Val Gly Ala Asn Ile Leu Lys Ile Lys Ala Tyr Asp 740 745 750 Ala
Asp Ser Gly Phe Asn Gly Lys Val Leu Phe Thr Ile Ser Asp Gly 755 760
765 Asn Thr Asp Ser Cys Phe Asn Ile Asp Met Glu Thr Gly Gln Leu Lys
770 775 780 Val Leu Met Pro Met Asp Arg Glu His Thr Asp Leu Tyr Leu
Leu Asn 785 790 795 800 Ile Thr Ile Tyr Asp Leu Gly Asn Pro Gln Lys
Ser Ser Trp Arg Leu 805 810 815 Leu Thr Ile Asn Val Glu Asp Ala Asn
Asp Asn Ser Pro Val Phe Ile 820 825 830 Gln Asp Ser Tyr Ser Val Asn
Ile Leu Glu Ser Ser Gly Ile Gly Thr 835 840 845 Glu Ile Ile Gln Val
Glu Ala Arg Asp Lys Asp Leu Gly Ser Asn Gly 850 855 860 Glu Val Thr
Tyr Ser Val Leu Thr Asp Thr Gln Gln Phe Ala Ile Asn 865 870 875 880
Ser Ser Thr Gly Ile Val Tyr Val Ala Asp Gln Leu Asp Arg Glu Ser 885
890 895 Lys Ala Asn Tyr Ser Leu Lys Ile Glu Ala Arg Asp Lys Ala Glu
Ser 900 905 910 Gly Gln Gln Leu Phe Ser Val Val Thr Leu Lys Val Phe
Leu Asp Asp 915 920 925 Val Asn Asp Cys Ser Pro Ala Phe Ile Pro Ser
Ser Tyr Ser Val Lys 930 935 940 Val Leu Glu Asp Leu Pro Val Gly Thr
Val Ile Ala Trp Leu Glu Thr 945 950 955 960 His Asp Pro Asp Leu Gly
Leu Gly Gly Gln Val Arg Tyr Ser Leu Val 965 970 975 Asn Asp Tyr Asn
Gly Arg Phe Glu Ile Asp Lys Ala Ser Gly Ala Ile 980 985 990 Arg Leu
Ser Lys Glu Leu Asp Tyr Glu Lys Gln Gln Phe Tyr Asn Leu 995 1000
1005
Thr Val Arg Ala Lys Asp Lys Gly Arg Pro Val Ser Leu Ser Ser Val
1010 1015 1020 Ser Phe Val Glu Val Glu Val Val Asp Val Asn Glu Asn
Leu His Thr 1025 1030 1035 1040 Pro Tyr Phe Pro Asp Phe Ala Val Val
Gly Ser Val Lys Glu Asn Ser 1045 1050 1055 Arg Ile Gly Thr Ser Val
Leu Gln Val Thr Ala Arg Asp Glu Asp Ser 1060 1065 1070 Gly Arg Asp
Gly Glu Ile Gln Tyr Ser Ile Arg Asp Gly Ser Gly Leu 1075 1080 1085
Gly Arg Phe Ser Ile Asp Asp Glu Ser Gly Val Ile Thr Ala Ala Asp
1090 1095 1100 Ile Leu Asp Arg Glu Thr Met Gly Ser Tyr Trp Leu Thr
Val Tyr Ala 1105 1110 1115 1120 Thr Asp Arg Gly Val Val Pro Leu Tyr
Ser Thr Ile Glu Val Tyr Ile 1125 1130 1135 Glu Val Glu Asp Val Asn
Asp Asn Ala Pro Leu Thr Ser Glu Pro Ile 1140 1145 1150 Tyr Tyr Pro
Val Val Met Glu Asn Ser Pro Lys Asp Val Ser Val Ile 1155 1160 1165
Gln Ile Gln Ala Glu Asp Pro Asp Ser Ser Ser Asn Glu Lys Leu Thr
1170 1175 1180 Tyr Arg Ile Thr Ser Gly Asn Pro Gln Asn Phe Phe Ala
Ile Asn Ile 1185 1190 1195 1200 Lys Thr Gly Leu Ile Thr Thr Thr Ser
Arg Lys Leu Asp Arg Glu Gln 1205 1210 1215 Gln Ala Glu His Phe Leu
Glu Val Thr Val Thr Asp Gly Gly Pro Ser 1220 1225 1230 Pro Lys Gln
Ser Thr Ile Trp Val Val Val Gln Val Leu Asp Glu Asn 1235 1240 1245
Asp Asn Lys Pro Gln Phe Pro Glu Lys Val Tyr Gln Ile Lys Leu Pro
1250 1255 1260 Glu Arg Asp Arg Lys Lys Arg Gly Glu Pro Ile Tyr Arg
Ala Phe Ala 1265 1270 1275 1280 Phe Asp Arg Asp Glu Gly Pro Asn Ala
Glu Ile Ser Tyr Ser Ile Val 1285 1290 1295 Asp Gly Asn Asp Asp Gly
Lys Phe Phe Ile Asp Pro Lys Thr Gly Met 1300 1305 1310 Val Ser Ser
Arg Lys Gln Phe Thr Ala Gly Ser Tyr Asp Ile Leu Thr 1315 1320 1325
Ile Lys Ala Val Asp Asn Gly Arg Pro Gln Lys Ser Ser Thr Ala Arg
1330 1335 1340 Leu His Ile Glu Trp Ile Lys Lys Pro Pro Pro Ser Pro
Ile Pro Leu 1345 1350 1355 1360 Thr Phe Asp Glu Pro Phe Tyr Asn Phe
Thr Val Met Glu Ser Asp Arg 1365 1370 1375 Val Thr Glu Ile Val Gly
Val Val Ser Val Gln Pro Ala Asn Thr Pro 1380 1385 1390 Leu Trp Phe
Asp Ile Val Gly Gly Asn Phe Asp Ser Ala Phe Asp Ala 1395 1400 1405
Glu Lys Gly Val Gly Thr Ile Val Ile Ala Lys Pro Leu Asp Ala Glu
1410 1415 1420 Gln Arg Ser Ile Tyr Asn Met Ser Val Glu Val Thr Asp
Gly Thr Asn 1425 1430 1435 1440 Val Ala Val Thr Gln Val Phe Ile Lys
Val Leu Asp Asn Asn Asp Asn 1445 1450 1455 Gly Pro Glu Phe Ser Gln
Pro Asn Tyr Asp Val Thr Ile Ser Glu Asp 1460 1465 1470 Val Leu Pro
Asp Thr Glu Ile Leu Gln Ile Glu Ala Thr Asp Arg Asp 1475 1480 1485
Glu Lys His Lys Leu Ser Tyr Thr Val His Ser Ser Ile Asp Ser Ile
1490 1495 1500 Ser Met Arg Lys Phe Arg Ile Asp Pro Ser Thr Gly Val
Leu Tyr Thr 1505 1510 1515 1520 Ala Glu Arg Leu Asp His Glu Ala Gln
Asp Lys His Ile Leu Asn Ile 1525 1530 1535 Met Val Arg Asp Gln Glu
Phe Pro Tyr Arg Arg Asn Leu Ala Arg Val 1540 1545 1550 Ile Val Asn
Val Glu Asp Ala Asn Asp His Ser Pro Tyr Phe Thr Asn 1555 1560 1565
Pro Leu Tyr Glu Ala Ser Val Phe Glu Ser Ala Ala Leu Gly Ser Ala
1570 1575 1580 Val Leu Gln Val Thr Ala Leu Asp Lys Asp Lys Gly Glu
Asn Ala Glu 1585 1590 1595 1600 Leu Ile Tyr Thr Ile Glu Ala Gly Asn
Thr Gly Asn Met Phe Lys Ile 1605 1610 1615 Glu Pro Val Leu Gly Ile
Ile Thr Ile Cys Lys Glu Pro Asp Met Thr 1620 1625 1630 Thr Met Gly
Gln Phe Val Leu Ser Ile Lys Val Thr Asp Gln Gly Ser 1635 1640 1645
Pro Pro Met Ser Ala Thr Ala Ile Val Arg Ile Ser Val Thr Met Ser
1650 1655 1660 Asp Asn Ser His Pro Lys Phe Ile His Lys Asp Tyr Gln
Ala Glu Val 1665 1670 1675 1680 Asn Glu Asn Val Asp Ile Gly Thr Ser
Val Ile Leu Ile Ser Ala Ile 1685 1690 1695 Ser Gln Ser Thr Leu Ile
Tyr Glu Val Lys Asp Gly Asp Ile Asn Gly 1700 1705 1710 Ile Phe Thr
Ile Asn Pro Tyr Ser Gly Val Ile Thr Thr Gln Lys Ala 1715 1720 1725
Leu Asp Tyr Glu Arg Thr Ser Ser Tyr Gln Leu Ile Ile Gln Ala Thr
1730 1735 1740 Asn Met Ala Gly Met Ala Ser Asn Ala Thr Val Asn Ile
Gln Ile Val 1745 1750 1755 1760 Asp Glu Asn Asp Asn Ala Pro Val Phe
Leu Phe Ser Gln Tyr Ser Gly 1765 1770 1775 Ser Leu Ser Glu Ala Ala
Pro Ile Asn Ser Ile Val Arg Ser Leu Asp 1780 1785 1790 Asn Ser Pro
Leu Val Ile Arg Ala Thr Asp Ala Asp Ser Asn Arg Asn 1795 1800 1805
Ala Leu Leu Val Tyr Gln Ile Val Glu Ser Thr Ala Lys Lys Phe Phe
1810 1815 1820 Thr Val Asp Ser Ser Thr Gly Ala Ile Arg Thr Ile Ala
Asn Leu Asp 1825 1830 1835 1840 His Glu Thr Ile Ala His Phe His Phe
His Val His Val Arg Asp Ser 1845 1850 1855 Gly Ser Pro Gln Leu Thr
Ala Glu Ser Pro Val Glu Val Asn Ile Glu 1860 1865 1870 Val Thr Asp
Val Asn Asp Asn Pro Pro Val Phe Thr Gln Ala Val Phe 1875 1880 1885
Glu Thr Ile Leu Leu Leu Pro Thr Tyr Val Gly Val Glu Val Leu Lys
1890 1895 1900 Val Ser Ala Thr Asp Pro Asp Ser Glu Val Pro Pro Glu
Leu Thr Tyr 1905 1910 1915 1920 Ser Leu Met Glu Gly Ser Leu Asp His
Phe Leu Ile Asp Ser Asn Ser 1925 1930 1935 Gly Val Leu Thr Ile Lys
Asn Asn Asn Leu Ser Lys Asp His Tyr Met 1940 1945 1950 Leu Ile Val
Lys Val Ser Asp Gly Lys Phe Tyr Ser Thr Ser Met Val 1955 1960 1965
Thr Ile Met Val Lys Glu Ala Met Asp Ser Gly Leu His Phe Thr Gln
1970 1975 1980 Ser Phe Tyr Ser Thr Ser Ile Ser Glu Asn Asn Thr Asn
Ile Thr Lys 1985 1990 1995 2000 Val Ala Ile Val Asn Ala Val Gly Asn
Arg Leu Asn Glu Pro Leu Lys 2005 2010 2015 Tyr Ser Ile Leu Asn Pro
Gly Asn Lys Phe Lys Ile Lys Ser Thr Ser 2020 2025 2030 Gly Val Ile
Gln Thr Thr Gly Val Pro Phe Asp Arg Glu Glu Gln Glu 2035 2040 2045
Leu Tyr Glu Leu Val Val Glu Ala Ser Arg Glu Leu Asp His Leu Arg
2050 2055 2060 Val Ala Arg Val Val Val Arg Val Asn Ile Glu Asp Ile
Asn Asp Asn 2065 2070 2075 2080 Ser Pro Val Phe Val Gly Leu Pro Tyr
Tyr Ala Ala Val Gln Val Asp 2085 2090 2095 Ala Glu Pro Gly Thr Leu
Ile Tyr Gln Val Thr Ala Ile Asp Lys Asp 2100 2105 2110 Lys Gly Pro
Asn Gly Glu Val Thr Tyr Val Leu Gln Asp Asp Tyr Gly 2115 2120 2125
His Phe Glu Ile Asn Pro Asn Ser Gly Asn Val Ile Leu Lys Glu Ala
2130 2135 2140 Phe Asn Ser Asp Leu Ser Asn Ile Glu Tyr Gly Val Thr
Ile Leu Ala 2145 2150 2155 2160 Lys Asp Gly Gly Lys Pro Ser Leu Ser
Thr Ser Val Glu Leu Pro Ile 2165 2170 2175 Thr Ile Val Asn Lys Ala
Met Pro Val Phe Asp Lys Pro Phe Tyr Thr 2180 2185 2190 Ala Ser Val
Asn Glu Asp Ile Arg Met Asn Thr Pro Ile Leu Ser Ile 2195 2200 2205
Asn Ala Thr Ser Pro Glu Gly Gln Gly Ile Ile Tyr Ile Ile Ile Asp
2210 2215 2220 Gly Asp Pro Phe Lys Gln Phe Asn Ile Asp Phe Asp Thr
Gly Val Leu 2225 2230 2235 2240 Lys Val Val Ser Pro Leu Asp Tyr Glu
Val Thr Ser Ala Tyr Lys Leu 2245 2250 2255 Thr Ile Arg Ala Ser Asp
Ala Leu Thr Gly Ala Arg Ala Glu Val Thr 2260 2265 2270 Val Asp Leu
Leu Val Asn Asp Val Asn Asp Asn Pro Pro Ile Phe Asp 2275 2280 2285
Gln Pro Thr Tyr Asn Thr Thr Leu Ser Glu Ala Ser Leu Ile Gly Thr
2290 2295 2300 Pro Val Leu Gln Val Val Ser Ile Asp Ala Asp Ser Glu
Asn Asn Lys 2305 2310 2315 2320 Met Val His Tyr Gln Ile Val Gln Asp
Thr Tyr Asn Ser Thr Asp Tyr 2325 2330 2335 Phe His Ile Asp Ser Ser
Ser Gly Leu Ile Leu Thr Ala Arg Met Leu 2340 2345 2350 Asp His Glu
Leu Val Gln His Cys Thr Leu Lys Val Arg Ser Ile Asp 2355 2360 2365
Ser Gly Phe Pro Ser Leu Ser Ser Glu Val Leu Val His Ile Tyr Ile
2370 2375 2380 Ser Asp Val Asn Asp Asn Pro Pro Val Phe Asn Gln Leu
Ile Tyr Glu 2385 2390 2395 2400 Ser Tyr Val Ser Glu Leu Ala Pro Arg
Gly His Phe Val Thr Cys Val 2405 2410 2415 Gln Ala Ser Asp Ala Asp
Ser Ser Asp Phe Asp Arg Leu Glu Tyr Ser 2420 2425 2430 Ile Leu Ser
Gly Asn Asp Arg Thr Ser Phe Leu Met Asp Ser Lys Ser 2435 2440 2445
Gly Val Ile Thr Leu Ser Asn His Arg Lys Gln Arg Met Glu Pro Leu
2450 2455 2460 Tyr Ser Leu Asn Val Ser Val Ser Asp Gly Leu Phe Thr
Ser Thr Ala 2465 2470 2475 2480 Gln Val His Ile Arg Val Leu Gly Ala
Asn Leu Tyr Ser Pro Ala Phe 2485 2490 2495 Ser Gln Ser Thr Tyr Val
Ala Glu Val Arg Glu Asn Val Ala Ala Gly 2500 2505 2510 Thr Lys Val
Ile His Val Arg Ala Thr Asp Gly Asp Pro Gly Thr Tyr 2515 2520 2525
Gly Gln Ile Ser Tyr Ala Ile Ile Asn Asp Phe Ala Lys Asp Arg Phe
2530 2535 2540 Leu Ile Asp Ser Asn Gly Gln Val Ile Thr Thr Glu Arg
Leu Asp Arg 2545 2550 2555 2560 Glu Asn Pro Leu Glu Gly Asp Val Ser
Ile Phe Val Arg Ala Leu Asp 2565 2570 2575 Gly Gly Gly Arg Thr Thr
Phe Cys Thr Val Arg Val Ile Val Val Asp 2580 2585 2590 Glu Asn Asp
Asn Ala Pro Gln Phe Met Thr Val Glu Tyr Arg Ala Ser 2595 2600 2605
Val Arg Ala Asp Val Gly Arg Gly His Leu Val Thr Gln Val Gln Ala
2610 2615 2620 Ile Asp Pro Asp Asp Gly Ala Asn Ser Arg Ile Thr Tyr
Ser Leu Tyr 2625 2630 2635 2640 Ser Glu Ala Ser Val Ser Val Ala Asp
Leu Leu Glu Ile Asp Pro Asp 2645 2650 2655 Asn Gly Trp Met Val Thr
Lys Gly Asn Phe Asn Gln Leu Lys Asn Thr 2660 2665 2670 Val Leu Ser
Phe Phe Val Lys Ala Val Asp Gly Gly Ile Pro Val Lys 2675 2680 2685
His Ser Leu Ile Pro Val Tyr Ile His Val Leu Pro Pro Glu Thr Phe
2690 2695 2700 Leu Pro Ser Phe Thr Gln Ser Gln Tyr Ser Phe Thr Ile
Ala Glu Asp 2705 2710 2715 2720 Thr Ala Ile Gly Ser Thr Val Asp Thr
Leu Arg Ile Leu Pro Ser Gln 2725 2730 2735 Asn Val Trp Phe Ser Thr
Val Asn Gly Glu Arg Pro Glu Asn Asn Lys 2740 2745 2750 Gly Gly Val
Phe Val Ile Glu Gln Glu Thr Gly Thr Ile Lys Leu Asp 2755 2760 2765
Lys Arg Leu Asp Arg Glu Thr Ser Pro Ala Phe His Phe Lys Val Ala
2770 2775 2780 Ala Thr Ile Pro Leu Asp Lys Val Asp Ile Val Phe Thr
Val Asp Val 2785 2790 2795 2800 Asp Ile Lys Val Leu Asp Leu Asn Asp
Asn Lys Pro Val Phe Glu Thr 2805 2810 2815 Ser Ser Tyr Asp Thr Ile
Ile Met Glu Gly Met Pro Val Gly Thr Lys 2820 2825 2830 Leu Thr Gln
Val Arg Ala Ile Asp Met Asp Trp Gly Ala Asn Gly Gln 2835 2840 2845
Val Thr Tyr Ser Leu His Ser Asp Ser Gln Pro Glu Lys Val Met Glu
2850 2855 2860 Ala Phe Asn Ile Asp Ser Asn Thr Gly Trp Ile Ser Thr
Leu Lys Asp 2865 2870 2875 2880 Leu Asp His Glu Thr Asp Pro Thr Phe
Thr Phe Ser Val Val Ala Ser 2885 2890 2895 Asp Leu Gly Glu Ala Phe
Ser Leu Ser Ser Thr Ala Leu Val Ser Val 2900 2905 2910 Arg Val Thr
Asp Ile Asn Asp Asn Ala Pro Val Phe Ala Gln Glu Val 2915 2920 2925
Tyr Arg Gly Asn Val Lys Glu Ser Asp Pro Pro Gly Glu Val Val Ala
2930 2935 2940 Val Leu Ser Thr Trp Asp Arg Asp Thr Ser Asp Val Asn
Arg Gln Val 2945 2950 2955 2960 Ser Tyr His Ile Thr Gly Gly Asn Pro
Arg Gly Arg Phe Ala Leu Gly 2965 2970 2975 Leu Val Gln Ser Glu Trp
Lys Val Tyr Val Lys Arg Pro Leu Asp Arg 2980 2985 2990 Glu Glu Gln
Asp Ile Tyr Phe Leu Asn Ile Thr Ala Thr Asp Gly Leu 2995 3000 3005
Phe Val Thr Gln Ala Met Val Glu Val Ser Val Ser Asp Val Asn Asp
3010 3015 3020 Asn Ser Pro Val Cys Asp Gln Val Ala Tyr Thr Ala Leu
Leu Pro Glu 3025 3030 3035 3040 Asp Ile Pro Ser Asn Lys Ile Ile Leu
Lys Val Ser Ala Lys Asp Ala 3045 3050 3055 Asp Ile Gly Ser Asn Gly
Tyr Ile Arg Tyr Ser Leu Tyr Gly Ser Gly 3060 3065 3070 Asn Ser Glu
Phe Phe Leu Asp Pro Glu Ser Gly Glu Leu Lys Thr Leu 3075 3080 3085
Ala Leu Leu Asp Arg Glu Arg Ile Pro Val Tyr Ser Leu Met Ala Lys
3090 3095 3100 Ala Thr Asp Gly Gly Gly Arg Phe Cys Gln Ser Asn Ile
His Leu Ile 3105 3110 3115 3120 Leu Glu Asp Val Asn Asp Asn Pro Pro
Val Phe Ser Ser Asp His Tyr 3125 3130 3135 Asn Thr Cys Val Tyr Glu
Asn Thr Ala Thr Lys Ala Leu Leu Thr Arg 3140 3145 3150 Val Gln Ala
Val Asp Pro Asp Ile Gly Ile Asn Arg Lys Val Val Tyr 3155 3160 3165
Ser Leu Ala Asp Ser Ala Gly Gly Val Phe Ser Ile Asp Ser Ser Ser
3170 3175 3180 Gly Ile Ile Ile Leu Glu Gln Pro Leu Asp Arg Glu Gln
Gln Ser Ser 3185 3190 3195 3200 Tyr Asn Ile Ser Val Arg Ala Thr Asp
Gln Ser Pro Gly Gln Ser Leu 3205 3210 3215 Ser Ser Leu Thr Thr Val
Thr Ile Thr Val Leu Asp Ile Asn Asp Asn 3220 3225 3230 Pro Pro Val
Phe Glu Arg Arg Asp Tyr Leu Val Thr Val Pro Glu Asp 3235 3240 3245
Thr Ser Pro Gly Thr Gln Val Leu Ala Val Phe Ala Thr Ser Lys Asp
3250 3255 3260 Ile Gly Thr Asn Ala Glu Ile Thr Tyr Leu Ile Arg Ser
Gly Asn Glu 3265 3270 3275 3280 Gln Gly Lys Phe Lys Ile Asn Pro Lys
Thr Gly Gly Ile Ser Val Ser 3285 3290 3295 Glu Val Leu Asp Tyr Glu
Leu Cys Lys Arg Phe Tyr Leu Val Val Glu 3300 3305 3310 Ala Lys Asp
Gly Gly Thr Pro Ala Leu Ser Ala Val Ala Thr Val Asn 3315 3320 3325
Ile Asn Leu Thr Asp Val Asn Asp Asn Pro Pro Lys Phe Ser Gln Asp
3330 3335 3340 Val Tyr Ser Ala Val Ile Ser Glu Asp Ala Leu Val Gly
Asp Ser Val 3345 3350 3355 3360 Ile Leu Leu Ile Ala Glu Asp Val Asp
Ser Gln Pro Asn Gly Gln Ile 3365 3370 3375 His Phe Ser Ile Val Asn
Gly Asp Arg Asp Asn Glu Phe Thr Val Asp 3380 3385 3390 Pro Val Leu
Gly Leu Val Lys Val Lys Lys Lys Leu Asp Arg Glu Arg 3395 3400 3405
Val Ser Gly Tyr Ser Leu Leu Val Gln Ala Val Asp Ser Gly Ile Pro
3410
3415 3420 Ala Met Ser Ser Thr Ala Thr Val Asn Ile Asp Ile Ser Asp
Val Asn 3425 3430 3435 3440 Asp Asn Ser Pro Val Phe Thr Pro Ala Asn
Tyr Thr Ala Val Ile Gln 3445 3450 3455 Glu Asn Lys Pro Val Gly Thr
Ser Ile Leu Gln Leu Val Val Thr Asp 3460 3465 3470 Arg Asp Ser Phe
His Asn Gly Pro Pro Phe Ser Phe Ser Ile Leu Ser 3475 3480 3485 Gly
Asn Glu Glu Glu Glu Phe Val Leu Asp Pro His Gly Ile Leu Arg 3490
3495 3500 Ser Ala Val Val Phe Gln His Thr Glu Ser Leu Glu Tyr Val
Leu Cys 3505 3510 3515 3520 Val Gln Ala Lys Asp Ser Gly Lys Pro Gln
Gln Val Ser His Thr Tyr 3525 3530 3535 Ile Arg Val Arg Val Ile Glu
Glu Ser Thr His Lys Pro Thr Ala Ile 3540 3545 3550 Pro Leu Glu Ile
Phe Ile Val Thr Met Glu Asp Asp Phe Pro Gly Gly 3555 3560 3565 Val
Ile Gly Lys Ile His Ala Thr Asp Gln Asp Met Tyr Asp Val Leu 3570
3575 3580 Thr Phe Ala Leu Lys Ser Glu Gln Lys Ser Leu Phe Lys Val
Asn Ser 3585 3590 3595 3600 His Asp Gly Lys Ile Ile Ala Leu Gly Gly
Leu Asp Ser Gly Lys Tyr 3605 3610 3615 Val Leu Asn Val Ser Val Ser
Asp Gly Arg Phe Gln Val Pro Ile Asp 3620 3625 3630 Val Val Val His
Val Glu Gln Leu Val His Glu Met Leu Gln Asn Thr 3635 3640 3645 Val
Thr Ile Arg Phe Glu Asn Val Ser Pro Glu Asp Phe Val Gly Leu 3650
3655 3660 His Met His Gly Phe Arg Arg Thr Leu Arg Asn Ala Val Leu
Thr Gln 3665 3670 3675 3680 Lys Gln Asp Ser Leu Arg Ile Ile Ser Ile
Gln Pro Val Ala Gly Thr 3685 3690 3695 Asn Gln Leu Asp Met Leu Phe
Ala Val Glu Met His Ser Ser Glu Phe 3700 3705 3710 Tyr Lys Pro Ala
Tyr Leu Ile Gln Lys Leu Ser Asn Ala Arg Arg His 3715 3720 3725 Leu
Glu Asn Ile Met Arg Ile Ser Ala Ile Leu Glu Lys Asn Cys Ser 3730
3735 3740 Gly Leu Asp Cys Gln Glu Gln His Cys Glu Gln Gly Leu Ser
Leu Asp 3745 3750 3755 3760 Ser His Ala Leu Met Thr Tyr Ser Thr Ala
Arg Ile Ser Phe Val Cys 3765 3770 3775 Pro Arg Phe Tyr Arg Asn Val
Arg Cys Thr Cys Asn Gly Gly Leu Cys 3780 3785 3790 Pro Gly Ser Asn
Asp Pro Cys Val Glu Lys Pro Cys Pro Gly Asp Met 3795 3800 3805 Gln
Cys Val Gly Tyr Glu Ala Ser Arg Arg Pro Phe Leu Cys Gln Cys 3810
3815 3820 Pro Pro Gly Lys Leu Gly Glu Cys Ser Gly His Thr Ser Leu
Ser Phe 3825 3830 3835 3840 Ala Gly Asn Ser Tyr Ile Lys Tyr Arg Leu
Ser Glu 3845 3850 5 13758 DNA homo sapiens 5 atgggacact gtgtgggcac
acggcctcct gcttgttgcc tcatcctcct gcttttcaag 60 cttttggcca
ctgtctccca ggggctgcca gggactggac ccctgggctt ccacttcaca 120
cattccattt ataatgctac cgtgtatgag aactcagcag caaggaccta cgtcaacagc
180 cagagtagaa tgggcatcac cttaatagat ctatcctggg atatcaaata
cagaatagtg 240 tccggagacg aggaaggctt tttcaaagca gaggaagtca
tcattgcaga tttctgtttt 300 ctcagaataa gaactaaagg tggcaattct
gccatattaa atagggaaat ccaggataat 360 tatttattga tagtaaaagg
ttctgtcaga ggagaggatt tggaagcatg gaccaaagtg 420 aatatacagg
ttttagatat gaatgatctg agacctttgt tttcacccac aacatactct 480
gttaccatag cagaaagcac acctctaagg actagtgttg cccaggtgac tgcaacagac
540 gcagatattg gttccaatgg agaattctac tactacttta aaaataaagt
tgatctcttt 600 tcagttcacc ccacgagtgg tgtcatctcc ttaagtggtc
gattaaatta tgatgaaaag 660 aataggtatg atctggaaat tttggctgtg
gaccggggaa tgaaactgta tgggaacaat 720 ggagtgagca gtactgcaaa
gctttatgtt cacattgagc gcataaatga acatgcccca 780 acaatccatg
tagtcactca tgttcctttc tcgttggaaa aagagccaac atatgcagtg 840
gtgacagttg atgacttaga tgatggagcg aatggagaga tcgaatctgt ttccattgtg
900 gctggggatc ctttagatca gttcttcctg gctaaggaag gaaagtggtt
gaatgagtac 960 aagattaagg agaggaagca gattgactgg gagagctttc
cctatggcta caatctcact 1020 cttcaagcaa aagacaaggg atctcctcaa
aaatgttcag cattaaaggc agtctacatt 1080 ggcaacccca caagagacac
tgtccccatt agatttgaaa aagaagtgta cgatgtgagc 1140 ataagtgaat
tttcccctcc tggtgtcgtg gttgctatag taaaattaag tcctgaaccg 1200
atagatgtgg aatacaaatt atctcctggt gaggatgcag tgtactttaa aattaatcct
1260 cggtcgggtc tgattgttac agcacggcca ctgaatactg ttaagaagga
ggtttataaa 1320 ctggaggtga caaacaagga aggagattta aaagcacagg
tcaccatcag catagaagat 1380 gcaaatgacc acaccccaga atttcagcaa
ccactgtatg atgcttatgt gaatgaaagt 1440 gtcccagtgg gaaccagcgt
tctaacagtt tcagcttctg ataaggataa aggagaaaat 1500 gggtacatca
cctatagtat cgctagcctg aatttgttac catttgtcat taatcagttt 1560
acaggtgtta ttagcacaac tgaagaactg gattttgaat cctccccaga aatttacaga
1620 ttcattgtta gagcctctga ctggggttca ccataccgcc atgaaagtga
ggtcaatgtg 1680 actattcgaa taggaaatgt caacgacaac agccctctct
ttgaaaaagt ggcttgccag 1740 ggagttattt catatgactt tccagttggt
ggtcacatca cagcagtctc agcgatcgat 1800 atcgatgaac ttgaacttgt
aaagtacaaa atcatttctg gaaatgaact tggcttcttt 1860 tatttaaacc
cagattctgg tgttttacag cttaaaaaat cactgacaaa ttctggcatt 1920
aaaaatggca attttgccct cagaattaca gcaactgatg gagagaatct tgcagacccc
1980 atgtctatta acatttcagt cctacatggg aaagtgtctt caaagagctt
cagttgcaga 2040 gaaactcgtg tggctcaaaa gctggcagag aaactactca
ttaaggcaaa agcaaatggg 2100 aaactgaatc tggaagatgg atttcttgac
ttttattcaa ttaatagaca gggaccatat 2160 tttgacaagt cttttccttc
tgatgtggct gtaaaggagg atctgccagt tggtgctaac 2220 attctgaaga
ttaaagccta tgatgccgac tctggcttca atggaaaagt gctatttaca 2280
atatcagatg gaaatacgga tagttgcttt aatattgata tggagactgg gcagcttaaa
2340 gtccttatgc ccatggatcg agaacacaca gacctctatc tccttaatat
caccatctat 2400 gacttaggta atccacagaa atcgtcatgg agactgctga
ccatcaatgt ggaggatgct 2460 aatgacaata gcccagtttt tattcaagac
agttactcag ttaacattct tgaaagttca 2520 ggcattggta ctgaaatcat
tcaagtggaa gccagagaca aagacttagg ttctaatggt 2580 gaagtgactt
actcagtctt gacagataca cagcagtttg ccatcaatag ctcaactgga 2640
atcgtttatg tagccgacca gttggaccgg gaatccaaag ccaattattc tttgaaaata
2700 gaagccaggg acaaggcaga gagtggtcag cagctgtttt cagttgtcac
tcttaaagtt 2760 tttttagatg atgtcaatga ctgctcccca gctttcattc
ccagtagcta tagtgtgaag 2820 gttcttgaag atctccctgt tggcactgtc
attgcttggc ttgagaccca tgatccagat 2880 cttggactgg ggggtcaagt
gcgctattct ttggtcaatg actataatgg gagatttgaa 2940 atagataaag
caagtggtgc catccgcttg agcaaagagc ttgattatga gaaacagcag 3000
ttctataacc ttactgtgcg ggccaaagac aaagggcggc ctgtctctct gtcatctgtt
3060 tcctttgttg aggtggaagt ggtggatgtc aatgaaaacc tccacactcc
ctatttccca 3120 gactttgctg ttgttggatc tgtaaaggaa aactcacgca
ttggaacaag cgtgctgcag 3180 gtgactgctc gagatgaaga ctccggaagg
gatggagaga tccagtactc catcagggat 3240 ggcagtggtc ttggaaggtt
cagtatagac gacgagagtg gggtcatcac tgccgcagac 3300 attcttgatc
gggagacaat ggggtcatac tggctaacag tgtatgccac agacaggggc 3360
gttgttccac tctactccac cattgaggtc tacattgaag ttgaagatgt gaatgacaat
3420 gccccgctga cctcagaacc tatatattat cctgttgtca tggaaaactc
tccaaaggac 3480 gtatctgtca ttcagatcca ggctgaagat cctgactcca
gttccaatga aaaactgaca 3540 tacaggatta caagtggaaa tcctcagaat
ttttttgcca tcaatatcaa aacaggtctg 3600 attacaacaa cttcaaggaa
attggatcga gaacagcagg cagaacattt tctggaggtg 3660 actgtgacag
atggtggtcc ctctccaaaa cagtcaacca tttgggtggt ggttcaggtt 3720
ctagatgaaa atgacaacaa gccccagttc ccagagaagg tctaccagat caagctgcca
3780 gaacgtgacc gaaagaagag aggagaaccg atttacaggg cttttgcatt
tgatagagat 3840 gagggcccca acgcagaaat ctcctacagt attgtggatg
ggaatgatga cggaaagttc 3900 tttattgacc ctaaaactgg gatggtttct
tctagaaagc agtttacagc aggcagttat 3960 gacatcctaa cgataaaggc
agtggacaat gggcgcccac agaaatcctc cacggcccgc 4020 ctccacattg
aatggattaa gaaaccaccc ccttcaccta taccattgac cttcgatgag 4080
ccgttttata acttcacagt catggaaagt gatagagtga ctgaaattgt aggggtggtg
4140 tctgtgcagc cagctaacac ccctctgtgg tttgacatag ttggggggaa
ttttgacagc 4200 gcttttgatg cagagaaggg tgttgggaca attgtcatcg
caaaaccttt ggatgcagag 4260 cagaggtcca tctataatat gagtgtggaa
gtcaccgatg ggacaaatgt tgctgttact 4320 caggtattta tcaaagtgct
ggataataat gataatggcc cagaattctc tcagccgaat 4380 tacgatgtga
caatttccga ggatgtgctt ccagacacgg agatcctgca gattgaagcc 4440
acagatagag atgagaagca caagctgagc tacactgttc atagcagcat cgactccatc
4500 agcatgagaa aattccggat tgaccctagc actggcgtgc tctatactgc
cgagaggctg 4560 gaccatgagg cccaggacaa gcacattctc aacataatgg
tcagagatca ggagtttcct 4620 tatcgaagaa acttggcccg agtcattgtg
aatgtggagg atgctaatga tcacagtcct 4680 tattttacca acccactgta
tgaagcgtct gtgtttgaat ctgctgctct gggatcagct 4740 gttctgcaag
tgacggctct ggacaaagac aaaggagaaa atgcagaact catatatacc 4800
atagaagcag ggaacactgg gaacatgttt aagatcgaac cggtcctagg catcatcacc
4860 atttgcaaag aaccagacat gacgacgatg ggtcagtttg tcctatccat
caaagtcaca 4920 gatcagggat ccccgccaat gtctgctact gcaattgtgc
gcatttccgt caccatgtct 4980 gacaattctc accccaagtt cattcacaaa
gactaccaag cagaagtaaa tgaaaatgtt 5040 gacattggaa catcagtcat
tctaatctct gccatcagtc aatctaccct catttatgaa 5100 gtcaaagatg
gagacattaa tgggatcttt accataaatc catattctgg agtcatcacc 5160
actcagaagg ccctggatta tgagcgcaca tcctcttatc aactcatcat tcaggccacc
5220 aatatggcag gaatggcttc caatgctaca gtcaatattc agattgttga
tgaaaatgat 5280 aatgccccag tttttctctt ttctcaatac tcaggcagcc
taagtgaggc tgccccaatt 5340 aatagcattg tcaggagctt ggataacagc
ccactggtga ttcgagccac agatgctgac 5400 agcaaccgga atgctctgct
tgtgtatcag attgtggagt caacagcaaa aaagtttttc 5460 acggtggact
ccagtacagg tgcaatcaga acaattgcca acctggacca tgaaaccatt 5520
gcccatttcc attttcatgt gcatgtgaga gacagtggta gcccccaact gactgcagag
5580 agtcccgttg aagtcaacat tgaggtgaca gatgtgaatg ataacccacc
tgtttttact 5640 caggctgtgt ttgagactat cttacttcta cctacctatg
ttggagtgga ggttctgaaa 5700 gttagtgcca cagatcctga ctctgaggta
ccccctgaac tgacatacag cctaatggaa 5760 ggcagtttgg atcatttttt
aattgactca aacagtggag tacttaccat aaaaaacaac 5820 aacctctcca
aggatcacta catgctgata gttaaggtgt ctgatggaaa gttctacagt 5880
acctccatgg tcaccatcat ggttaaagaa gccatggaca gcggcctcca ctttacacaa
5940 agcttctatt ccacctcaat ctcagagaac aacactaaca taaccaaagt
tgctattgtc 6000 aatgcagttg gaaatcgcct taatgagccc ttaaaataca
gcatcttaaa cccaggaaat 6060 aagttcaaga taaaatctac ctcaggggtc
attcagacga ctggagtccc ctttgaccgt 6120 gaagaacaag agttatatga
gctggtggta gaagccagcc gtgagctgga ccatctgcgt 6180 gtggccagag
tggtggtcag ggttaacatt gaagacataa atgacaattc tccagtcttt 6240
gtgggcctcc catactatgc tgctgttcaa gtggatgcgg aacccgggac tctgatttat
6300 caggtgacag ccattgacaa agataaaggt ccaaatggag aagtgaccta
tgtcctgcag 6360 gatgactatg gccactttga aattaaccct aattcaggga
atgttatttt aaaggaagca 6420 ttcaactctg acttgtccaa cattgagtat
ggagtcacca tcctagccaa ggatggcgga 6480 aaaccttctt tgtctacatc
tgtggagctt cccatcacta ttgtcaacaa agcaatgcct 6540 gtgtttgata
agccctttta tacagcatct gtcaatgaag acatcagaat gaacacaccc 6600
atcctaagca tcaatgccac cagtccagaa ggccaaggca tcatatatat cattatcgat
6660 ggggaccctt ttaaacagtt taacattgac tttgacactg gggtcctgaa
agttgttagc 6720 cctttggatt atgaagttac atctgcttac aagctgacaa
taagagccag cgacgccctt 6780 actggtgcta gggctgaagt cactgttgac
ttgctagtta atgatgtaaa tgacaacccc 6840 cctattttcg atcagcctac
atacaataca acactatcag aagcatctct tattgggaca 6900 cctgttttac
aagttgtctc tattgatgca gactcagaaa acaataaaat ggtacattat 6960
cagattgtcc aggataccta caatagcaca gattattttc acatagatag ctcaagtggc
7020 ttaatcctga cagcacgaat gctggaccat gagttagtac aacactgcac
tttgaaagtc 7080 agatcaatag atagtggctt cccatcactg agcagtgagg
ttctcgttca tatctacatc 7140 tctgatgtaa atgacaaccc tccagttttt
aatcagctca tttatgagtc atatgtgagt 7200 gaattagccc cccggggcca
ttttgtaacc tgtgtacaag cctctgatgc agacagctct 7260 gattttgacc
ggttggaata tagcatttta tctgggaatg accggacgag ctttctgatg 7320
gacagcaaga gtggagttat cacattgtcc aaccatcgga agcagcggat ggagcctctg
7380 tacagtctca atgtgtctgt ctctgatggg ttgttcacca gcactgcaca
ggtgcatatt 7440 agggtacttg gggctaactt gtacagccct gccttttcac
aaagcacata cgtagctgag 7500 gtgagagaga acgtggctgc aggaacaaag
gtaattcatg ttcgagccac agatggtgat 7560 ccagggactt atgggcagat
cagctatgcc atcatcaatg actttgccaa ggatcgattc 7620 ctcatagaca
gcaatgggca ggtcatcacc acagaaaggc tagaccggga aaaccctcta 7680
gaaggggatg ttagtatttt tgtgagggcc cttgatggtg gagggagaac aactttctgc
7740 actgtgagag tgattgttgt ggatgaaaat gacaatgctc cccagttcat
gacagtggaa 7800 tatagagcca gtgtcagggc agatgttgga aggggccact
tggtcactca agttcaagcc 7860 atagatcccg atgatggagc aaattcaagg
attacttatt ccctctatag cgaggcctct 7920 gtttcagtgg ccgacctcct
ggaaatcgat cctgacaatg gctggatggt cacaaagggt 7980 aattttaacc
agctgaaaaa tacagtgctt tcgttctttg tcaaagcagt agatgggggc 8040
atcccagtaa agcactccct cattcctgtc tatatccacg tcttgccccc tgaaacgttc
8100 ttgccatcat tcacccagtc tcagtattcc tttaccattg cagaagatac
agccattggg 8160 agtacagtgg acaccctgag gattttgccc agtcagaatg
tctggttcag cacagttaat 8220 ggggaacggc cagaaaataa caaagggggc
gtattcgtca tagaacagga aacaggcact 8280 attaagcttg acaaacgcct
tgaccgtgaa accagcccag ctttccactt taaagtagca 8340 gccactatac
ccctggacaa agtagacatt gtgtttactg tggatgtaga tatcaaggta 8400
ttggatttga atgacaacaa gccagtcttt gaaacttcaa gctatgacac cattataatg
8460 gaagggatgc ctgttggcac caaactcaca caagtgagag ctattgatat
ggactgggga 8520 gccaatggac aagtcactta ctccctccac tcggattccc
agcccgaaaa ggtaatggaa 8580 gcattcaata ttgacagcaa cacgggctgg
atcagtacct tgaaggacct agatcacgag 8640 acagacccca cattcacctt
ctctgtggtg gcctctgacc ttggagaggc attctctctt 8700 tcctccacgg
ccttggtctc tgtcagagtg acagatataa atgacaatgc accagtcttc 8760
gcgcaggaag tgtaccgagg gaatgtgaag gagagcgacc caccgggcga ggtggtagcc
8820 gtcctcagca cctgggacag agacacatcc gacgttaatc gccaagtgag
ctaccatatt 8880 acaggaggaa accctcgagg aaggtttgct ctgggcctgg
tgcaaagtga gtggaaggtc 8940 tatgtgaaga ggcctctaga cagagaagaa
caggacattt actttctcaa tatcactgcc 9000 actgatgggc tttttgtcac
acaggccatg gtggaagtga gcgtcagtga tgtgaatgac 9060 aatagcccag
tgtgtgatca ggttgcatat acagcattac ttcctgaaga cattccatca 9120
aataaaatca tcctgaaagt cagtgcaaag gatgctgata ttggatccaa tggatatata
9180 cgatactcac tctatggatc tggaaacagt gaattttttc tagatccaga
aagtggcgag 9240 ttaaaaacct tggctctgtt ggaccgggag aggatccccg
tgtacagcct gatggccaag 9300 gccactgacg ggggtggcag gttctgccag
tccaacatcc acctaatcct ggaggatgtg 9360 aatgataacc cccctgtgtt
ttcttctgac cactacaaca cctgtgtcta tgagaacaca 9420 gccaccaagg
ctctgttgac cagagttcaa gccgtggacc ccgacattgg catcaatagg 9480
aaggtcgtgt actccctggc agactcagct ggtggggtct tctccattga cagctcatct
9540 ggcatcatca tcctggagca gccactggac cgtgagcagc agtcttcgta
caacatcagc 9600 gtgcgggcca ctgaccagag tcctggacag tccctgtcct
ctctcactac tgtcaccatc 9660 accgttctgg acattaatga caacccccct
gtgtttgaga ggagggacta cctggtgacg 9720 gtgcctgagg acacctcccc
tggcacccaa gtccttgctg tttttgccac cagcaaagat 9780 attggcacaa
atgctgagat cacttatctc atccggtctg ggaacgaaca agggaaattt 9840
aagatcaacc ccaagacagg gggtatttct gtctctgaag tcctggacta tgaattatgc
9900 aaaaggtttt acctggtagt ggaagccaaa gatgggggca ccccagctct
cagcgctgtg 9960 gccactgtca acatcaacct cacagatgtt aatgacaacc
ctcccaagtt cagccaagac 10020 gtctacagtg cggttatcag tgaagacgcc
ttggtgggag actctgtcat tttgctaata 10080 gcagaagatg tagacagcca
gcccaacgga cagattcatt tttccattgt gaatggagat 10140 cgggacaatg
aatttactgt agatcctgtc ttgggacttg tgaaagttaa gaagaaattg 10200
gaccgggaac gggtgtctgg atactctctg cttgtccagg ccgtagacag tggcattcct
10260 gcaatgtcat caactgcaac tgtcaacatt gatatttctg atgtgaatga
caacagcccg 10320 gtgtttacac ctgccaacta tactgctgtg attcaggaaa
ataagccagt gggcaccagc 10380 atcttgcagc tggtggtgac agacagagac
tcctttcaca atgggcctcc cttttcattc 10440 tctattttgt cgggaaatga
agaggaggag tttgtgttgg accctcatgg gatcttgcgg 10500 tcggctgtgg
tcttccagca cacagagtct ctggaatacg tgttgtgtgt ccaggcaaag 10560
gattcaggca aaccccagca agtttctcac acttacatcc gcgtgcgagt cattgaggaa
10620 agcacccaca agcccacagc cattcccctg gaaattttca ttgtcaccat
ggaggatgac 10680 tttcctggtg gggtcattgg gaagattcat gccacagatc
aagacatgta tgatgtgctc 10740 acatttgccc tgaaatcgga gcagaaaagc
ttatttaaag tgaacagtca cgatgggaaa 10800 atcatcgccc tgggaggcct
ggacagcggc aagtatgtcc tgaatgtgtc tgtgagtgat 10860 ggtcgcttcc
aggtacccat tgatgtggtc gtgcatgtgg agcagttggt gcatgagatg 10920
ctgcagaaca ctgtcaccat ccgctttgaa aatgtgtccc ctgaggactt cgtggggctg
10980 cacatgcatg ggttccggcg caccctgcgg aatgcagtcc tcacccagaa
gcaggacagc 11040 ctgcgcatca tcagcatcca gcccgtggca ggcaccaacc
aactggacat gctgtttgcg 11100 gtggagatgc acagcagcga gttctacaag
ccagcctacc tgatccagaa gctgtccaat 11160 gctagaagac acctggagaa
tatcatgcgc atctcagcca tcttggagaa gaactgctca 11220 gggctggact
gtcaggaaca gcattgtgag caaggcttgt cactcgattc ccacgcgctc 11280
atgacctaca gcacggctcg catcagcttt gtgtgtccgc gtttctacag gaacgtgcgt
11340 tgcacctgca atggaggact gtgtccgggg tccaacgatc cttgtgtgga
gaagccgtgt 11400 ccaggggaca tgcagtgtgt cggttatgaa gccagcagga
gaccgttcct ctgccagtgt 11460 ccaccaggga agctcggaga gtgctcaggg
cacacttctc tcagctttgc tggaaacagt 11520 tacatcaaat atcggctttc
tgaaaatagc aaagaagagg atttcaaact agctctgcgt 11580 cttcgaacac
tgcaaagcaa tgggattata atgtacacca gagcaaatcc ctgcataatt 11640
ctgaagattg tggatggcaa gctgtggttc cagctggact gcggcagcgg ccctggaatc
11700 ttgggcatct cgggccgtgc tgtcaacgac gggagctggc actcggtctt
cctggagctc 11760 aaccgcaatt tcacgagcct gtccctggat gacagctacg
tggagcggcg ccgggcgccc 11820 ctctacttcc agacgctgag cactgagagt
agcatctact tcggcgccct ggtgcaagcg 11880 gataacatcc gcagcctgac
tgacacgcgg gtcacgcagg tgctcagcgg cttccagggc 11940 tgcctggact
cggtgatact gaataacaat gagctgccgc tgcagaacaa gcgcagcagc 12000
ttcgcggagg tggtgggcct gacggagctg aagctgggct gcgtgctcta tcccgacgcc
12060 tgcaagcgca gcccgtgcca gcacgggggc agctgcactg gcctgccatc
ggggggctat 12120 cagtgtacct gtctctcaca gtttacgggg agaaactgtg
aatctgagat tacagcctgc 12180 ttcccaaacc cctgccggaa tggaggatcc
tgcgatccaa taggaaacac tttcatctgc 12240 aattgtaaag ctgggctcac
tggagtcacg tgtgaggagg acatcaatga gtgcgaacga 12300 gaggagtgtg
agaacggagg
ctcctgcgtg aacgtgttcg gctccttcct ctgcaactgc 12360 acgccgggct
acgtgggcca gtactgcggg ctgcgccccg tggtggtacc caatatccag 12420
gctggccact cctacgtggg gaaggaggag ctcatcggca tcgccgtggt cctcttcgtc
12480 atcttcatcc tggtggttct cttcatagtc ttccgcaaga aggtcttccg
caagaactac 12540 tcccgcaaca acatcacgct agtgcaggac ccggccaccg
ccgccctgct taacaagagc 12600 aatggcatcc cgttccggaa cctgcgcggc
agtggggacg gccgcaacgt ctaccaggag 12660 gtggggcccc cgcaggtccc
cgtgcgcccc atggcctaca caccctgctt ccagagtgac 12720 tccaggagca
acctggataa gatcgtggac gggctgggag gcgagcacca ggaaatgacc 12780
acgtttcacc ctgagtcgcc ccgcatcctg acagcccggc ggggcgtggt cgtgtgcagt
12840 gtggccccca acctccccgc cgtgtcaccc tgccgctccg actgcgactc
catccggaag 12900 aatggctggg acgcgggaac tgagaacaaa ggggttgatg
acccgggaga agtgacctgc 12960 tttgcaggta gtaataaagg cagcaactct
gaagttcagt ccctcagctc cttccagtca 13020 gattctggtg acgacaatgc
ctccatagtg actgtcattc agcttgtcaa caatgtagtt 13080 gacactatag
agaatgaagt gtctgtcatg gaccaaggac agaactacaa ccgagcctat 13140
cactgggaca cctctgattg gatgccaggg gcccgcctgt cggacataga ggaagtgccc
13200 aactatgaga accaggatgg agggtctgca caccagggga gcacacggga
gctggagagc 13260 gattactacc tgggtggtta tgacattgac agtgaatacc
caccccctca tgaagaggag 13320 ttcttgagtc aggaccagct gcctcctcct
ctcccggagg acttcccaga ccaatatgag 13380 gccctgccac cctcccagcc
tgtctccctg gccagcacac tgagcccaga ctgcaggaga 13440 aggccccagt
ttcatcctag ccagtatctc cctcctcacc cattccccaa cgaaacggat 13500
ttggtgggcc cgcctgccag ctgtgaattt agtacttttg ctgtgagcat gaaccagggc
13560 acagagccca caggcccagc agacagcgtg tctctgtcct tgcacaattc
cagaggcacc 13620 tcatcctcgg atgtgtctgc caactgcggc tttgacgatt
ccgaagtagc catgagtgac 13680 tacgagagcg tgggagagct cagcctcgcc
agccttcaca ttccctttgt ggagactcag 13740 catcagactc aagtgtag 13758 6
4585 PRT homo sapiens 6 Met Gly His Cys Val Gly Thr Arg Pro Pro Ala
Cys Cys Leu Ile Leu 1 5 10 15 Leu Leu Phe Lys Leu Leu Ala Thr Val
Ser Gln Gly Leu Pro Gly Thr 20 25 30 Gly Pro Leu Gly Phe His Phe
Thr His Ser Ile Tyr Asn Ala Thr Val 35 40 45 Tyr Glu Asn Ser Ala
Ala Arg Thr Tyr Val Asn Ser Gln Ser Arg Met 50 55 60 Gly Ile Thr
Leu Ile Asp Leu Ser Trp Asp Ile Lys Tyr Arg Ile Val 65 70 75 80 Ser
Gly Asp Glu Glu Gly Phe Phe Lys Ala Glu Glu Val Ile Ile Ala 85 90
95 Asp Phe Cys Phe Leu Arg Ile Arg Thr Lys Gly Gly Asn Ser Ala Ile
100 105 110 Leu Asn Arg Glu Ile Gln Asp Asn Tyr Leu Leu Ile Val Lys
Gly Ser 115 120 125 Val Arg Gly Glu Asp Leu Glu Ala Trp Thr Lys Val
Asn Ile Gln Val 130 135 140 Leu Asp Met Asn Asp Leu Arg Pro Leu Phe
Ser Pro Thr Thr Tyr Ser 145 150 155 160 Val Thr Ile Ala Glu Ser Thr
Pro Leu Arg Thr Ser Val Ala Gln Val 165 170 175 Thr Ala Thr Asp Ala
Asp Ile Gly Ser Asn Gly Glu Phe Tyr Tyr Tyr 180 185 190 Phe Lys Asn
Lys Val Asp Leu Phe Ser Val His Pro Thr Ser Gly Val 195 200 205 Ile
Ser Leu Ser Gly Arg Leu Asn Tyr Asp Glu Lys Asn Arg Tyr Asp 210 215
220 Leu Glu Ile Leu Ala Val Asp Arg Gly Met Lys Leu Tyr Gly Asn Asn
225 230 235 240 Gly Val Ser Ser Thr Ala Lys Leu Tyr Val His Ile Glu
Arg Ile Asn 245 250 255 Glu His Ala Pro Thr Ile His Val Val Thr His
Val Pro Phe Ser Leu 260 265 270 Glu Lys Glu Pro Thr Tyr Ala Val Val
Thr Val Asp Asp Leu Asp Asp 275 280 285 Gly Ala Asn Gly Glu Ile Glu
Ser Val Ser Ile Val Ala Gly Asp Pro 290 295 300 Leu Asp Gln Phe Phe
Leu Ala Lys Glu Gly Lys Trp Leu Asn Glu Tyr 305 310 315 320 Lys Ile
Lys Glu Arg Lys Gln Ile Asp Trp Glu Ser Phe Pro Tyr Gly 325 330 335
Tyr Asn Leu Thr Leu Gln Ala Lys Asp Lys Gly Ser Pro Gln Lys Cys 340
345 350 Ser Ala Leu Lys Ala Val Tyr Ile Gly Asn Pro Thr Arg Asp Thr
Val 355 360 365 Pro Ile Arg Phe Glu Lys Glu Val Tyr Asp Val Ser Ile
Ser Glu Phe 370 375 380 Ser Pro Pro Gly Val Val Val Ala Ile Val Lys
Leu Ser Pro Glu Pro 385 390 395 400 Ile Asp Val Glu Tyr Lys Leu Ser
Pro Gly Glu Asp Ala Val Tyr Phe 405 410 415 Lys Ile Asn Pro Arg Ser
Gly Leu Ile Val Thr Ala Arg Pro Leu Asn 420 425 430 Thr Val Lys Lys
Glu Val Tyr Lys Leu Glu Val Thr Asn Lys Glu Gly 435 440 445 Asp Leu
Lys Ala Gln Val Thr Ile Ser Ile Glu Asp Ala Asn Asp His 450 455 460
Thr Pro Glu Phe Gln Gln Pro Leu Tyr Asp Ala Tyr Val Asn Glu Ser 465
470 475 480 Val Pro Val Gly Thr Ser Val Leu Thr Val Ser Ala Ser Asp
Lys Asp 485 490 495 Lys Gly Glu Asn Gly Tyr Ile Thr Tyr Ser Ile Ala
Ser Leu Asn Leu 500 505 510 Leu Pro Phe Val Ile Asn Gln Phe Thr Gly
Val Ile Ser Thr Thr Glu 515 520 525 Glu Leu Asp Phe Glu Ser Ser Pro
Glu Ile Tyr Arg Phe Ile Val Arg 530 535 540 Ala Ser Asp Trp Gly Ser
Pro Tyr Arg His Glu Ser Glu Val Asn Val 545 550 555 560 Thr Ile Arg
Ile Gly Asn Val Asn Asp Asn Ser Pro Leu Phe Glu Lys 565 570 575 Val
Ala Cys Gln Gly Val Ile Ser Tyr Asp Phe Pro Val Gly Gly His 580 585
590 Ile Thr Ala Val Ser Ala Ile Asp Ile Asp Glu Leu Glu Leu Val Lys
595 600 605 Tyr Lys Ile Ile Ser Gly Asn Glu Leu Gly Phe Phe Tyr Leu
Asn Pro 610 615 620 Asp Ser Gly Val Leu Gln Leu Lys Lys Ser Leu Thr
Asn Ser Gly Ile 625 630 635 640 Lys Asn Gly Asn Phe Ala Leu Arg Ile
Thr Ala Thr Asp Gly Glu Asn 645 650 655 Leu Ala Asp Pro Met Ser Ile
Asn Ile Ser Val Leu His Gly Lys Val 660 665 670 Ser Ser Lys Ser Phe
Ser Cys Arg Glu Thr Arg Val Ala Gln Lys Leu 675 680 685 Ala Glu Lys
Leu Leu Ile Lys Ala Lys Ala Asn Gly Lys Leu Asn Leu 690 695 700 Glu
Asp Gly Phe Leu Asp Phe Tyr Ser Ile Asn Arg Gln Gly Pro Tyr 705 710
715 720 Phe Asp Lys Ser Phe Pro Ser Asp Val Ala Val Lys Glu Asp Leu
Pro 725 730 735 Val Gly Ala Asn Ile Leu Lys Ile Lys Ala Tyr Asp Ala
Asp Ser Gly 740 745 750 Phe Asn Gly Lys Val Leu Phe Thr Ile Ser Asp
Gly Asn Thr Asp Ser 755 760 765 Cys Phe Asn Ile Asp Met Glu Thr Gly
Gln Leu Lys Val Leu Met Pro 770 775 780 Met Asp Arg Glu His Thr Asp
Leu Tyr Leu Leu Asn Ile Thr Ile Tyr 785 790 795 800 Asp Leu Gly Asn
Pro Gln Lys Ser Ser Trp Arg Leu Leu Thr Ile Asn 805 810 815 Val Glu
Asp Ala Asn Asp Asn Ser Pro Val Phe Ile Gln Asp Ser Tyr 820 825 830
Ser Val Asn Ile Leu Glu Ser Ser Gly Ile Gly Thr Glu Ile Ile Gln 835
840 845 Val Glu Ala Arg Asp Lys Asp Leu Gly Ser Asn Gly Glu Val Thr
Tyr 850 855 860 Ser Val Leu Thr Asp Thr Gln Gln Phe Ala Ile Asn Ser
Ser Thr Gly 865 870 875 880 Ile Val Tyr Val Ala Asp Gln Leu Asp Arg
Glu Ser Lys Ala Asn Tyr 885 890 895 Ser Leu Lys Ile Glu Ala Arg Asp
Lys Ala Glu Ser Gly Gln Gln Leu 900 905 910 Phe Ser Val Val Thr Leu
Lys Val Phe Leu Asp Asp Val Asn Asp Cys 915 920 925 Ser Pro Ala Phe
Ile Pro Ser Ser Tyr Ser Val Lys Val Leu Glu Asp 930 935 940 Leu Pro
Val Gly Thr Val Ile Ala Trp Leu Glu Thr His Asp Pro Asp 945 950 955
960 Leu Gly Leu Gly Gly Gln Val Arg Tyr Ser Leu Val Asn Asp Tyr Asn
965 970 975 Gly Arg Phe Glu Ile Asp Lys Ala Ser Gly Ala Ile Arg Leu
Ser Lys 980 985 990 Glu Leu Asp Tyr Glu Lys Gln Gln Phe Tyr Asn Leu
Thr Val Arg Ala 995 1000 1005 Lys Asp Lys Gly Arg Pro Val Ser Leu
Ser Ser Val Ser Phe Val Glu 1010 1015 1020 Val Glu Val Val Asp Val
Asn Glu Asn Leu His Thr Pro Tyr Phe Pro 1025 1030 1035 1040 Asp Phe
Ala Val Val Gly Ser Val Lys Glu Asn Ser Arg Ile Gly Thr 1045 1050
1055 Ser Val Leu Gln Val Thr Ala Arg Asp Glu Asp Ser Gly Arg Asp
Gly 1060 1065 1070 Glu Ile Gln Tyr Ser Ile Arg Asp Gly Ser Gly Leu
Gly Arg Phe Ser 1075 1080 1085 Ile Asp Asp Glu Ser Gly Val Ile Thr
Ala Ala Asp Ile Leu Asp Arg 1090 1095 1100 Glu Thr Met Gly Ser Tyr
Trp Leu Thr Val Tyr Ala Thr Asp Arg Gly 1105 1110 1115 1120 Val Val
Pro Leu Tyr Ser Thr Ile Glu Val Tyr Ile Glu Val Glu Asp 1125 1130
1135 Val Asn Asp Asn Ala Pro Leu Thr Ser Glu Pro Ile Tyr Tyr Pro
Val 1140 1145 1150 Val Met Glu Asn Ser Pro Lys Asp Val Ser Val Ile
Gln Ile Gln Ala 1155 1160 1165 Glu Asp Pro Asp Ser Ser Ser Asn Glu
Lys Leu Thr Tyr Arg Ile Thr 1170 1175 1180 Ser Gly Asn Pro Gln Asn
Phe Phe Ala Ile Asn Ile Lys Thr Gly Leu 1185 1190 1195 1200 Ile Thr
Thr Thr Ser Arg Lys Leu Asp Arg Glu Gln Gln Ala Glu His 1205 1210
1215 Phe Leu Glu Val Thr Val Thr Asp Gly Gly Pro Ser Pro Lys Gln
Ser 1220 1225 1230 Thr Ile Trp Val Val Val Gln Val Leu Asp Glu Asn
Asp Asn Lys Pro 1235 1240 1245 Gln Phe Pro Glu Lys Val Tyr Gln Ile
Lys Leu Pro Glu Arg Asp Arg 1250 1255 1260 Lys Lys Arg Gly Glu Pro
Ile Tyr Arg Ala Phe Ala Phe Asp Arg Asp 1265 1270 1275 1280 Glu Gly
Pro Asn Ala Glu Ile Ser Tyr Ser Ile Val Asp Gly Asn Asp 1285 1290
1295 Asp Gly Lys Phe Phe Ile Asp Pro Lys Thr Gly Met Val Ser Ser
Arg 1300 1305 1310 Lys Gln Phe Thr Ala Gly Ser Tyr Asp Ile Leu Thr
Ile Lys Ala Val 1315 1320 1325 Asp Asn Gly Arg Pro Gln Lys Ser Ser
Thr Ala Arg Leu His Ile Glu 1330 1335 1340 Trp Ile Lys Lys Pro Pro
Pro Ser Pro Ile Pro Leu Thr Phe Asp Glu 1345 1350 1355 1360 Pro Phe
Tyr Asn Phe Thr Val Met Glu Ser Asp Arg Val Thr Glu Ile 1365 1370
1375 Val Gly Val Val Ser Val Gln Pro Ala Asn Thr Pro Leu Trp Phe
Asp 1380 1385 1390 Ile Val Gly Gly Asn Phe Asp Ser Ala Phe Asp Ala
Glu Lys Gly Val 1395 1400 1405 Gly Thr Ile Val Ile Ala Lys Pro Leu
Asp Ala Glu Gln Arg Ser Ile 1410 1415 1420 Tyr Asn Met Ser Val Glu
Val Thr Asp Gly Thr Asn Val Ala Val Thr 1425 1430 1435 1440 Gln Val
Phe Ile Lys Val Leu Asp Asn Asn Asp Asn Gly Pro Glu Phe 1445 1450
1455 Ser Gln Pro Asn Tyr Asp Val Thr Ile Ser Glu Asp Val Leu Pro
Asp 1460 1465 1470 Thr Glu Ile Leu Gln Ile Glu Ala Thr Asp Arg Asp
Glu Lys His Lys 1475 1480 1485 Leu Ser Tyr Thr Val His Ser Ser Ile
Asp Ser Ile Ser Met Arg Lys 1490 1495 1500 Phe Arg Ile Asp Pro Ser
Thr Gly Val Leu Tyr Thr Ala Glu Arg Leu 1505 1510 1515 1520 Asp His
Glu Ala Gln Asp Lys His Ile Leu Asn Ile Met Val Arg Asp 1525 1530
1535 Gln Glu Phe Pro Tyr Arg Arg Asn Leu Ala Arg Val Ile Val Asn
Val 1540 1545 1550 Glu Asp Ala Asn Asp His Ser Pro Tyr Phe Thr Asn
Pro Leu Tyr Glu 1555 1560 1565 Ala Ser Val Phe Glu Ser Ala Ala Leu
Gly Ser Ala Val Leu Gln Val 1570 1575 1580 Thr Ala Leu Asp Lys Asp
Lys Gly Glu Asn Ala Glu Leu Ile Tyr Thr 1585 1590 1595 1600 Ile Glu
Ala Gly Asn Thr Gly Asn Met Phe Lys Ile Glu Pro Val Leu 1605 1610
1615 Gly Ile Ile Thr Ile Cys Lys Glu Pro Asp Met Thr Thr Met Gly
Gln 1620 1625 1630 Phe Val Leu Ser Ile Lys Val Thr Asp Gln Gly Ser
Pro Pro Met Ser 1635 1640 1645 Ala Thr Ala Ile Val Arg Ile Ser Val
Thr Met Ser Asp Asn Ser His 1650 1655 1660 Pro Lys Phe Ile His Lys
Asp Tyr Gln Ala Glu Val Asn Glu Asn Val 1665 1670 1675 1680 Asp Ile
Gly Thr Ser Val Ile Leu Ile Ser Ala Ile Ser Gln Ser Thr 1685 1690
1695 Leu Ile Tyr Glu Val Lys Asp Gly Asp Ile Asn Gly Ile Phe Thr
Ile 1700 1705 1710 Asn Pro Tyr Ser Gly Val Ile Thr Thr Gln Lys Ala
Leu Asp Tyr Glu 1715 1720 1725 Arg Thr Ser Ser Tyr Gln Leu Ile Ile
Gln Ala Thr Asn Met Ala Gly 1730 1735 1740 Met Ala Ser Asn Ala Thr
Val Asn Ile Gln Ile Val Asp Glu Asn Asp 1745 1750 1755 1760 Asn Ala
Pro Val Phe Leu Phe Ser Gln Tyr Ser Gly Ser Leu Ser Glu 1765 1770
1775 Ala Ala Pro Ile Asn Ser Ile Val Arg Ser Leu Asp Asn Ser Pro
Leu 1780 1785 1790 Val Ile Arg Ala Thr Asp Ala Asp Ser Asn Arg Asn
Ala Leu Leu Val 1795 1800 1805 Tyr Gln Ile Val Glu Ser Thr Ala Lys
Lys Phe Phe Thr Val Asp Ser 1810 1815 1820 Ser Thr Gly Ala Ile Arg
Thr Ile Ala Asn Leu Asp His Glu Thr Ile 1825 1830 1835 1840 Ala His
Phe His Phe His Val His Val Arg Asp Ser Gly Ser Pro Gln 1845 1850
1855 Leu Thr Ala Glu Ser Pro Val Glu Val Asn Ile Glu Val Thr Asp
Val 1860 1865 1870 Asn Asp Asn Pro Pro Val Phe Thr Gln Ala Val Phe
Glu Thr Ile Leu 1875 1880 1885 Leu Leu Pro Thr Tyr Val Gly Val Glu
Val Leu Lys Val Ser Ala Thr 1890 1895 1900 Asp Pro Asp Ser Glu Val
Pro Pro Glu Leu Thr Tyr Ser Leu Met Glu 1905 1910 1915 1920 Gly Ser
Leu Asp His Phe Leu Ile Asp Ser Asn Ser Gly Val Leu Thr 1925 1930
1935 Ile Lys Asn Asn Asn Leu Ser Lys Asp His Tyr Met Leu Ile Val
Lys 1940 1945 1950 Val Ser Asp Gly Lys Phe Tyr Ser Thr Ser Met Val
Thr Ile Met Val 1955 1960 1965 Lys Glu Ala Met Asp Ser Gly Leu His
Phe Thr Gln Ser Phe Tyr Ser 1970 1975 1980 Thr Ser Ile Ser Glu Asn
Asn Thr Asn Ile Thr Lys Val Ala Ile Val 1985 1990 1995 2000 Asn Ala
Val Gly Asn Arg Leu Asn Glu Pro Leu Lys Tyr Ser Ile Leu 2005 2010
2015 Asn Pro Gly Asn Lys Phe Lys Ile Lys Ser Thr Ser Gly Val Ile
Gln 2020 2025 2030 Thr Thr Gly Val Pro Phe Asp Arg Glu Glu Gln Glu
Leu Tyr Glu Leu 2035 2040 2045 Val Val Glu Ala Ser Arg Glu Leu Asp
His Leu Arg Val Ala Arg Val 2050 2055 2060 Val Val Arg Val Asn Ile
Glu Asp Ile Asn Asp Asn Ser Pro Val Phe 2065 2070 2075 2080 Val Gly
Leu Pro Tyr Tyr Ala Ala Val Gln Val Asp Ala Glu Pro Gly 2085 2090
2095 Thr Leu Ile Tyr Gln Val Thr Ala Ile Asp Lys Asp Lys Gly Pro
Asn 2100 2105 2110 Gly Glu Val Thr Tyr Val Leu Gln Asp Asp Tyr Gly
His Phe Glu Ile 2115 2120 2125 Asn Pro Asn Ser Gly Asn Val Ile Leu
Lys Glu Ala Phe Asn Ser Asp 2130 2135 2140 Leu Ser Asn Ile Glu Tyr
Gly Val Thr Ile Leu Ala Lys Asp Gly Gly 2145 2150 2155 2160 Lys Pro
Ser Leu Ser Thr Ser Val Glu Leu Pro Ile Thr Ile Val Asn 2165 2170
2175 Lys Ala Met Pro Val Phe Asp Lys Pro Phe Tyr Thr Ala Ser Val
Asn
2180 2185 2190 Glu Asp Ile Arg Met Asn Thr Pro Ile Leu Ser Ile Asn
Ala Thr Ser 2195 2200 2205 Pro Glu Gly Gln Gly Ile Ile Tyr Ile Ile
Ile Asp Gly Asp Pro Phe 2210 2215 2220 Lys Gln Phe Asn Ile Asp Phe
Asp Thr Gly Val Leu Lys Val Val Ser 2225 2230 2235 2240 Pro Leu Asp
Tyr Glu Val Thr Ser Ala Tyr Lys Leu Thr Ile Arg Ala 2245 2250 2255
Ser Asp Ala Leu Thr Gly Ala Arg Ala Glu Val Thr Val Asp Leu Leu
2260 2265 2270 Val Asn Asp Val Asn Asp Asn Pro Pro Ile Phe Asp Gln
Pro Thr Tyr 2275 2280 2285 Asn Thr Thr Leu Ser Glu Ala Ser Leu Ile
Gly Thr Pro Val Leu Gln 2290 2295 2300 Val Val Ser Ile Asp Ala Asp
Ser Glu Asn Asn Lys Met Val His Tyr 2305 2310 2315 2320 Gln Ile Val
Gln Asp Thr Tyr Asn Ser Thr Asp Tyr Phe His Ile Asp 2325 2330 2335
Ser Ser Ser Gly Leu Ile Leu Thr Ala Arg Met Leu Asp His Glu Leu
2340 2345 2350 Val Gln His Cys Thr Leu Lys Val Arg Ser Ile Asp Ser
Gly Phe Pro 2355 2360 2365 Ser Leu Ser Ser Glu Val Leu Val His Ile
Tyr Ile Ser Asp Val Asn 2370 2375 2380 Asp Asn Pro Pro Val Phe Asn
Gln Leu Ile Tyr Glu Ser Tyr Val Ser 2385 2390 2395 2400 Glu Leu Ala
Pro Arg Gly His Phe Val Thr Cys Val Gln Ala Ser Asp 2405 2410 2415
Ala Asp Ser Ser Asp Phe Asp Arg Leu Glu Tyr Ser Ile Leu Ser Gly
2420 2425 2430 Asn Asp Arg Thr Ser Phe Leu Met Asp Ser Lys Ser Gly
Val Ile Thr 2435 2440 2445 Leu Ser Asn His Arg Lys Gln Arg Met Glu
Pro Leu Tyr Ser Leu Asn 2450 2455 2460 Val Ser Val Ser Asp Gly Leu
Phe Thr Ser Thr Ala Gln Val His Ile 2465 2470 2475 2480 Arg Val Leu
Gly Ala Asn Leu Tyr Ser Pro Ala Phe Ser Gln Ser Thr 2485 2490 2495
Tyr Val Ala Glu Val Arg Glu Asn Val Ala Ala Gly Thr Lys Val Ile
2500 2505 2510 His Val Arg Ala Thr Asp Gly Asp Pro Gly Thr Tyr Gly
Gln Ile Ser 2515 2520 2525 Tyr Ala Ile Ile Asn Asp Phe Ala Lys Asp
Arg Phe Leu Ile Asp Ser 2530 2535 2540 Asn Gly Gln Val Ile Thr Thr
Glu Arg Leu Asp Arg Glu Asn Pro Leu 2545 2550 2555 2560 Glu Gly Asp
Val Ser Ile Phe Val Arg Ala Leu Asp Gly Gly Gly Arg 2565 2570 2575
Thr Thr Phe Cys Thr Val Arg Val Ile Val Val Asp Glu Asn Asp Asn
2580 2585 2590 Ala Pro Gln Phe Met Thr Val Glu Tyr Arg Ala Ser Val
Arg Ala Asp 2595 2600 2605 Val Gly Arg Gly His Leu Val Thr Gln Val
Gln Ala Ile Asp Pro Asp 2610 2615 2620 Asp Gly Ala Asn Ser Arg Ile
Thr Tyr Ser Leu Tyr Ser Glu Ala Ser 2625 2630 2635 2640 Val Ser Val
Ala Asp Leu Leu Glu Ile Asp Pro Asp Asn Gly Trp Met 2645 2650 2655
Val Thr Lys Gly Asn Phe Asn Gln Leu Lys Asn Thr Val Leu Ser Phe
2660 2665 2670 Phe Val Lys Ala Val Asp Gly Gly Ile Pro Val Lys His
Ser Leu Ile 2675 2680 2685 Pro Val Tyr Ile His Val Leu Pro Pro Glu
Thr Phe Leu Pro Ser Phe 2690 2695 2700 Thr Gln Ser Gln Tyr Ser Phe
Thr Ile Ala Glu Asp Thr Ala Ile Gly 2705 2710 2715 2720 Ser Thr Val
Asp Thr Leu Arg Ile Leu Pro Ser Gln Asn Val Trp Phe 2725 2730 2735
Ser Thr Val Asn Gly Glu Arg Pro Glu Asn Asn Lys Gly Gly Val Phe
2740 2745 2750 Val Ile Glu Gln Glu Thr Gly Thr Ile Lys Leu Asp Lys
Arg Leu Asp 2755 2760 2765 Arg Glu Thr Ser Pro Ala Phe His Phe Lys
Val Ala Ala Thr Ile Pro 2770 2775 2780 Leu Asp Lys Val Asp Ile Val
Phe Thr Val Asp Val Asp Ile Lys Val 2785 2790 2795 2800 Leu Asp Leu
Asn Asp Asn Lys Pro Val Phe Glu Thr Ser Ser Tyr Asp 2805 2810 2815
Thr Ile Ile Met Glu Gly Met Pro Val Gly Thr Lys Leu Thr Gln Val
2820 2825 2830 Arg Ala Ile Asp Met Asp Trp Gly Ala Asn Gly Gln Val
Thr Tyr Ser 2835 2840 2845 Leu His Ser Asp Ser Gln Pro Glu Lys Val
Met Glu Ala Phe Asn Ile 2850 2855 2860 Asp Ser Asn Thr Gly Trp Ile
Ser Thr Leu Lys Asp Leu Asp His Glu 2865 2870 2875 2880 Thr Asp Pro
Thr Phe Thr Phe Ser Val Val Ala Ser Asp Leu Gly Glu 2885 2890 2895
Ala Phe Ser Leu Ser Ser Thr Ala Leu Val Ser Val Arg Val Thr Asp
2900 2905 2910 Ile Asn Asp Asn Ala Pro Val Phe Ala Gln Glu Val Tyr
Arg Gly Asn 2915 2920 2925 Val Lys Glu Ser Asp Pro Pro Gly Glu Val
Val Ala Val Leu Ser Thr 2930 2935 2940 Trp Asp Arg Asp Thr Ser Asp
Val Asn Arg Gln Val Ser Tyr His Ile 2945 2950 2955 2960 Thr Gly Gly
Asn Pro Arg Gly Arg Phe Ala Leu Gly Leu Val Gln Ser 2965 2970 2975
Glu Trp Lys Val Tyr Val Lys Arg Pro Leu Asp Arg Glu Glu Gln Asp
2980 2985 2990 Ile Tyr Phe Leu Asn Ile Thr Ala Thr Asp Gly Leu Phe
Val Thr Gln 2995 3000 3005 Ala Met Val Glu Val Ser Val Ser Asp Val
Asn Asp Asn Ser Pro Val 3010 3015 3020 Cys Asp Gln Val Ala Tyr Thr
Ala Leu Leu Pro Glu Asp Ile Pro Ser 3025 3030 3035 3040 Asn Lys Ile
Ile Leu Lys Val Ser Ala Lys Asp Ala Asp Ile Gly Ser 3045 3050 3055
Asn Gly Tyr Ile Arg Tyr Ser Leu Tyr Gly Ser Gly Asn Ser Glu Phe
3060 3065 3070 Phe Leu Asp Pro Glu Ser Gly Glu Leu Lys Thr Leu Ala
Leu Leu Asp 3075 3080 3085 Arg Glu Arg Ile Pro Val Tyr Ser Leu Met
Ala Lys Ala Thr Asp Gly 3090 3095 3100 Gly Gly Arg Phe Cys Gln Ser
Asn Ile His Leu Ile Leu Glu Asp Val 3105 3110 3115 3120 Asn Asp Asn
Pro Pro Val Phe Ser Ser Asp His Tyr Asn Thr Cys Val 3125 3130 3135
Tyr Glu Asn Thr Ala Thr Lys Ala Leu Leu Thr Arg Val Gln Ala Val
3140 3145 3150 Asp Pro Asp Ile Gly Ile Asn Arg Lys Val Val Tyr Ser
Leu Ala Asp 3155 3160 3165 Ser Ala Gly Gly Val Phe Ser Ile Asp Ser
Ser Ser Gly Ile Ile Ile 3170 3175 3180 Leu Glu Gln Pro Leu Asp Arg
Glu Gln Gln Ser Ser Tyr Asn Ile Ser 3185 3190 3195 3200 Val Arg Ala
Thr Asp Gln Ser Pro Gly Gln Ser Leu Ser Ser Leu Thr 3205 3210 3215
Thr Val Thr Ile Thr Val Leu Asp Ile Asn Asp Asn Pro Pro Val Phe
3220 3225 3230 Glu Arg Arg Asp Tyr Leu Val Thr Val Pro Glu Asp Thr
Ser Pro Gly 3235 3240 3245 Thr Gln Val Leu Ala Val Phe Ala Thr Ser
Lys Asp Ile Gly Thr Asn 3250 3255 3260 Ala Glu Ile Thr Tyr Leu Ile
Arg Ser Gly Asn Glu Gln Gly Lys Phe 3265 3270 3275 3280 Lys Ile Asn
Pro Lys Thr Gly Gly Ile Ser Val Ser Glu Val Leu Asp 3285 3290 3295
Tyr Glu Leu Cys Lys Arg Phe Tyr Leu Val Val Glu Ala Lys Asp Gly
3300 3305 3310 Gly Thr Pro Ala Leu Ser Ala Val Ala Thr Val Asn Ile
Asn Leu Thr 3315 3320 3325 Asp Val Asn Asp Asn Pro Pro Lys Phe Ser
Gln Asp Val Tyr Ser Ala 3330 3335 3340 Val Ile Ser Glu Asp Ala Leu
Val Gly Asp Ser Val Ile Leu Leu Ile 3345 3350 3355 3360 Ala Glu Asp
Val Asp Ser Gln Pro Asn Gly Gln Ile His Phe Ser Ile 3365 3370 3375
Val Asn Gly Asp Arg Asp Asn Glu Phe Thr Val Asp Pro Val Leu Gly
3380 3385 3390 Leu Val Lys Val Lys Lys Lys Leu Asp Arg Glu Arg Val
Ser Gly Tyr 3395 3400 3405 Ser Leu Leu Val Gln Ala Val Asp Ser Gly
Ile Pro Ala Met Ser Ser 3410 3415 3420 Thr Ala Thr Val Asn Ile Asp
Ile Ser Asp Val Asn Asp Asn Ser Pro 3425 3430 3435 3440 Val Phe Thr
Pro Ala Asn Tyr Thr Ala Val Ile Gln Glu Asn Lys Pro 3445 3450 3455
Val Gly Thr Ser Ile Leu Gln Leu Val Val Thr Asp Arg Asp Ser Phe
3460 3465 3470 His Asn Gly Pro Pro Phe Ser Phe Ser Ile Leu Ser Gly
Asn Glu Glu 3475 3480 3485 Glu Glu Phe Val Leu Asp Pro His Gly Ile
Leu Arg Ser Ala Val Val 3490 3495 3500 Phe Gln His Thr Glu Ser Leu
Glu Tyr Val Leu Cys Val Gln Ala Lys 3505 3510 3515 3520 Asp Ser Gly
Lys Pro Gln Gln Val Ser His Thr Tyr Ile Arg Val Arg 3525 3530 3535
Val Ile Glu Glu Ser Thr His Lys Pro Thr Ala Ile Pro Leu Glu Ile
3540 3545 3550 Phe Ile Val Thr Met Glu Asp Asp Phe Pro Gly Gly Val
Ile Gly Lys 3555 3560 3565 Ile His Ala Thr Asp Gln Asp Met Tyr Asp
Val Leu Thr Phe Ala Leu 3570 3575 3580 Lys Ser Glu Gln Lys Ser Leu
Phe Lys Val Asn Ser His Asp Gly Lys 3585 3590 3595 3600 Ile Ile Ala
Leu Gly Gly Leu Asp Ser Gly Lys Tyr Val Leu Asn Val 3605 3610 3615
Ser Val Ser Asp Gly Arg Phe Gln Val Pro Ile Asp Val Val Val His
3620 3625 3630 Val Glu Gln Leu Val His Glu Met Leu Gln Asn Thr Val
Thr Ile Arg 3635 3640 3645 Phe Glu Asn Val Ser Pro Glu Asp Phe Val
Gly Leu His Met His Gly 3650 3655 3660 Phe Arg Arg Thr Leu Arg Asn
Ala Val Leu Thr Gln Lys Gln Asp Ser 3665 3670 3675 3680 Leu Arg Ile
Ile Ser Ile Gln Pro Val Ala Gly Thr Asn Gln Leu Asp 3685 3690 3695
Met Leu Phe Ala Val Glu Met His Ser Ser Glu Phe Tyr Lys Pro Ala
3700 3705 3710 Tyr Leu Ile Gln Lys Leu Ser Asn Ala Arg Arg His Leu
Glu Asn Ile 3715 3720 3725 Met Arg Ile Ser Ala Ile Leu Glu Lys Asn
Cys Ser Gly Leu Asp Cys 3730 3735 3740 Gln Glu Gln His Cys Glu Gln
Gly Leu Ser Leu Asp Ser His Ala Leu 3745 3750 3755 3760 Met Thr Tyr
Ser Thr Ala Arg Ile Ser Phe Val Cys Pro Arg Phe Tyr 3765 3770 3775
Arg Asn Val Arg Cys Thr Cys Asn Gly Gly Leu Cys Pro Gly Ser Asn
3780 3785 3790 Asp Pro Cys Val Glu Lys Pro Cys Pro Gly Asp Met Gln
Cys Val Gly 3795 3800 3805 Tyr Glu Ala Ser Arg Arg Pro Phe Leu Cys
Gln Cys Pro Pro Gly Lys 3810 3815 3820 Leu Gly Glu Cys Ser Gly His
Thr Ser Leu Ser Phe Ala Gly Asn Ser 3825 3830 3835 3840 Tyr Ile Lys
Tyr Arg Leu Ser Glu Asn Ser Lys Glu Glu Asp Phe Lys 3845 3850 3855
Leu Ala Leu Arg Leu Arg Thr Leu Gln Ser Asn Gly Ile Ile Met Tyr
3860 3865 3870 Thr Arg Ala Asn Pro Cys Ile Ile Leu Lys Ile Val Asp
Gly Lys Leu 3875 3880 3885 Trp Phe Gln Leu Asp Cys Gly Ser Gly Pro
Gly Ile Leu Gly Ile Ser 3890 3895 3900 Gly Arg Ala Val Asn Asp Gly
Ser Trp His Ser Val Phe Leu Glu Leu 3905 3910 3915 3920 Asn Arg Asn
Phe Thr Ser Leu Ser Leu Asp Asp Ser Tyr Val Glu Arg 3925 3930 3935
Arg Arg Ala Pro Leu Tyr Phe Gln Thr Leu Ser Thr Glu Ser Ser Ile
3940 3945 3950 Tyr Phe Gly Ala Leu Val Gln Ala Asp Asn Ile Arg Ser
Leu Thr Asp 3955 3960 3965 Thr Arg Val Thr Gln Val Leu Ser Gly Phe
Gln Gly Cys Leu Asp Ser 3970 3975 3980 Val Ile Leu Asn Asn Asn Glu
Leu Pro Leu Gln Asn Lys Arg Ser Ser 3985 3990 3995 4000 Phe Ala Glu
Val Val Gly Leu Thr Glu Leu Lys Leu Gly Cys Val Leu 4005 4010 4015
Tyr Pro Asp Ala Cys Lys Arg Ser Pro Cys Gln His Gly Gly Ser Cys
4020 4025 4030 Thr Gly Leu Pro Ser Gly Gly Tyr Gln Cys Thr Cys Leu
Ser Gln Phe 4035 4040 4045 Thr Gly Arg Asn Cys Glu Ser Glu Ile Thr
Ala Cys Phe Pro Asn Pro 4050 4055 4060 Cys Arg Asn Gly Gly Ser Cys
Asp Pro Ile Gly Asn Thr Phe Ile Cys 4065 4070 4075 4080 Asn Cys Lys
Ala Gly Leu Thr Gly Val Thr Cys Glu Glu Asp Ile Asn 4085 4090 4095
Glu Cys Glu Arg Glu Glu Cys Glu Asn Gly Gly Ser Cys Val Asn Val
4100 4105 4110 Phe Gly Ser Phe Leu Cys Asn Cys Thr Pro Gly Tyr Val
Gly Gln Tyr 4115 4120 4125 Cys Gly Leu Arg Pro Val Val Val Pro Asn
Ile Gln Ala Gly His Ser 4130 4135 4140 Tyr Val Gly Lys Glu Glu Leu
Ile Gly Ile Ala Val Val Leu Phe Val 4145 4150 4155 4160 Ile Phe Ile
Leu Val Val Leu Phe Ile Val Phe Arg Lys Lys Val Phe 4165 4170 4175
Arg Lys Asn Tyr Ser Arg Asn Asn Ile Thr Leu Val Gln Asp Pro Ala
4180 4185 4190 Thr Ala Ala Leu Leu Asn Lys Ser Asn Gly Ile Pro Phe
Arg Asn Leu 4195 4200 4205 Arg Gly Ser Gly Asp Gly Arg Asn Val Tyr
Gln Glu Val Gly Pro Pro 4210 4215 4220 Gln Val Pro Val Arg Pro Met
Ala Tyr Thr Pro Cys Phe Gln Ser Asp 4225 4230 4235 4240 Ser Arg Ser
Asn Leu Asp Lys Ile Val Asp Gly Leu Gly Gly Glu His 4245 4250 4255
Gln Glu Met Thr Thr Phe His Pro Glu Ser Pro Arg Ile Leu Thr Ala
4260 4265 4270 Arg Arg Gly Val Val Val Cys Ser Val Ala Pro Asn Leu
Pro Ala Val 4275 4280 4285 Ser Pro Cys Arg Ser Asp Cys Asp Ser Ile
Arg Lys Asn Gly Trp Asp 4290 4295 4300 Ala Gly Thr Glu Asn Lys Gly
Val Asp Asp Pro Gly Glu Val Thr Cys 4305 4310 4315 4320 Phe Ala Gly
Ser Asn Lys Gly Ser Asn Ser Glu Val Gln Ser Leu Ser 4325 4330 4335
Ser Phe Gln Ser Asp Ser Gly Asp Asp Asn Ala Ser Ile Val Thr Val
4340 4345 4350 Ile Gln Leu Val Asn Asn Val Val Asp Thr Ile Glu Asn
Glu Val Ser 4355 4360 4365 Val Met Asp Gln Gly Gln Asn Tyr Asn Arg
Ala Tyr His Trp Asp Thr 4370 4375 4380 Ser Asp Trp Met Pro Gly Ala
Arg Leu Ser Asp Ile Glu Glu Val Pro 4385 4390 4395 4400 Asn Tyr Glu
Asn Gln Asp Gly Gly Ser Ala His Gln Gly Ser Thr Arg 4405 4410 4415
Glu Leu Glu Ser Asp Tyr Tyr Leu Gly Gly Tyr Asp Ile Asp Ser Glu
4420 4425 4430 Tyr Pro Pro Pro His Glu Glu Glu Phe Leu Ser Gln Asp
Gln Leu Pro 4435 4440 4445 Pro Pro Leu Pro Glu Asp Phe Pro Asp Gln
Tyr Glu Ala Leu Pro Pro 4450 4455 4460 Ser Gln Pro Val Ser Leu Ala
Ser Thr Leu Ser Pro Asp Cys Arg Arg 4465 4470 4475 4480 Arg Pro Gln
Phe His Pro Ser Gln Tyr Leu Pro Pro His Pro Phe Pro 4485 4490 4495
Asn Glu Thr Asp Leu Val Gly Pro Pro Ala Ser Cys Glu Phe Ser Thr
4500 4505 4510 Phe Ala Val Ser Met Asn Gln Gly Thr Glu Pro Thr Gly
Pro Ala Asp 4515 4520 4525 Ser Val Ser Leu Ser Leu His Asn Ser Arg
Gly Thr Ser Ser Ser Asp 4530 4535 4540 Val Ser Ala Asn Cys Gly Phe
Asp Asp Ser Glu Val Ala Met Ser Asp 4545 4550 4555 4560 Tyr Glu Ser
Val Gly Glu Leu Ser Leu Ala Ser Leu His Ile Pro Phe 4565 4570 4575
Val Glu Thr Gln His Gln Thr Gln Val 4580 4585 7 13767 DNA homo
sapiens 7 atggatataa ttatgggaca ctgtgtgggc acacggcctc
ctgcttgttg cctcatcctc 60 ctgcttttca agcttttggc cactgtctcc
caggggctgc cagggactgg acccctgggc 120 ttccacttca cacattccat
ttataatgct accgtgtatg agaactcagc agcaaggacc 180 tacgtcaaca
gccagagtag aatgggcatc accttaatag atctatcctg ggatatcaaa 240
tacagaatag tgtccggaga cgaggaaggc tttttcaaag cagaggaagt catcattgca
300 gatttctgtt ttctcagaat aagaactaaa ggtggcaatt ctgccatatt
aaatagggaa 360 atccaggata attatttatt gatagtaaaa ggttctgtca
gaggagagga tttggaagca 420 tggaccaaag tgaatataca ggttttagat
atgaatgatc tgagaccttt gttttcaccc 480 acaacatact ctgttaccat
agcagaaagc acacctctaa ggactagtgt tgcccaggtg 540 actgcaacag
acgcagatat tggttccaat ggagaattct actactactt taaaaataaa 600
gttgatctct tttcagttca ccccacgagt ggtgtcatct ccttaagtgg tcgattaaat
660 tatgatgaaa agaataggta tgatctggaa attttggctg tggaccgggg
aatgaaactg 720 tatgggaaca atggagtgag cagtactgca aagctttatg
ttcacattga gcgcataaat 780 gaacatgccc caacaatcca tgtagtcact
catgttcctt tctcgttgga aaaagagcca 840 acatatgcag tggtgacagt
tgatgactta gatgatggag cgaatggaga gatcgaatct 900 gtttccattg
tggctgggga tcctttagat cagttcttcc tggctaagga aggaaagtgg 960
ttgaatgagt acaagattaa ggagaggaag cagattgact gggagagctt tccctatggc
1020 tacaatctca ctcttcaagc aaaagacaag ggatctcctc aaaaatgttc
agcattaaag 1080 gcagtctaca ttggcaaccc cacaagagac actgtcccca
ttagatttga aaaagaagtg 1140 tacgatgtga gcataagtga attttcccct
cctggtgtcg tggttgctat agtaaaatta 1200 agtcctgaac cgatagatgt
ggaatacaaa ttatctcctg gtgaggatgc agtgtacttt 1260 aaaattaatc
ctcggtcggg tctgattgtt acagcacggc cactgaatac tgttaagaag 1320
gaggtttata aactggaggt gacaaacaag gaaggagatt taaaagcaca ggtcaccatc
1380 agcatagaag atgcaaatga ccacacccca gaatttcagc aaccactgta
tgatgcttat 1440 gtgaatgaaa gtgtcccagt gggaaccagc gttctaacag
tttcagcttc tgataaggat 1500 aaaggagaaa atgggtacat cacctatagt
atcgctagcc tgaatttgtt accatttgtc 1560 attaatcagt ttacaggtgt
tattagcaca actgaagaac tggattttga atcctcccca 1620 gaaatttaca
gattcattgt tagagcctct gactggggtt caccataccg ccatgaaagt 1680
gaggtcaatg tgactattcg aataggaaat gtcaacgaca acagccctct ctttgaaaaa
1740 gtggcttgcc agggagttat ttcatatgac tttccagttg gtggtcacat
cacagcagtc 1800 tcagcgatcg atatcgatga acttgaactt gtaaagtaca
aaatcatttc tggaaatgaa 1860 cttggcttct tttatttaaa cccagattct
ggtgttttac agcttaaaaa atcactgaca 1920 aattctggca ttaaaaatgg
caattttgcc ctcagaatta cagcaactga tggagagaat 1980 cttgcagacc
ccatgtctat taacatttca gtcctacatg ggaaagtgtc ttcaaagagc 2040
ttcagttgca gagaaactcg tgtggctcaa aagctggcag agaaactact cattaaggca
2100 aaagcaaatg ggaaactgaa tctggaagat ggatttcttg acttttattc
aattaataga 2160 cagggaccat attttgacaa gtcttttcct tctgatgtgg
ctgtaaagga ggatctgcca 2220 gttggtgcta acattctgaa gattaaagcc
tatgatgccg actctggctt caatggaaaa 2280 gtgctattta caatatcaga
tggaaatacg gatagttgct ttaatattga tatggagact 2340 gggcagctta
aagtccttat gcccatggat cgagaacaca cagacctcta tctccttaat 2400
atcaccatct atgacttagg taatccacag aaatcgtcat ggagactgct gaccatcaat
2460 gtggaggatg ctaatgacaa tagcccagtt tttattcaag acagttactc
agttaacatt 2520 cttgaaagtt caggcattgg tactgaaatc attcaagtgg
aagccagaga caaagactta 2580 ggttctaatg gtgaagtgac ttactcagtc
ttgacagata cacagcagtt tgccatcaat 2640 agctcaactg gaatcgttta
tgtagccgac cagttggacc gggaatccaa agccaattat 2700 tctttgaaaa
tagaagccag ggacaaggca gagagtggtc agcagctgtt ttcagttgtc 2760
actcttaaag tttttttaga tgatgtcaat gactgctccc cagctttcat tcccagtagc
2820 tatagtgtga aggttcttga agatctccct gttggcactg tcattgcttg
gcttgagacc 2880 catgatccag atcttggact ggggggtcaa gtgcgctatt
ctttggtcaa tgactataat 2940 gggagatttg aaatagataa agcaagtggt
gccatccgct tgagcaaaga gcttgattat 3000 gagaaacagc agttctataa
ccttactgtg cgggccaaag acaaagggcg gcctgtctct 3060 ctgtcatctg
tttcctttgt tgaggtggaa gtggtggatg tcaatgaaaa cctccacact 3120
ccctatttcc cagactttgc tgttgttgga tctgtaaagg aaaactcacg cattggaaca
3180 agcgtgctgc aggtgactgc tcgagatgaa gactccggaa gggatggaga
gatccagtac 3240 tccatcaggg atggcagtgg tcttggaagg ttcagtatag
acgacgagag tggggtcatc 3300 actgccgcag acattcttga tcgggagaca
atggggtcat actggctaac agtgtatgcc 3360 acagacaggg gcgttgttcc
actctactcc accattgagg tctacattga agttgaagat 3420 gtgaatgaca
atgccccgct gacctcagaa cctatatatt atcctgttgt catggaaaac 3480
tctccaaagg acgtatctgt cattcagatc caggctgaag atcctgactc cagttccaat
3540 gaaaaactga catacaggat tacaagtgga aatcctcaga atttttttgc
catcaatatc 3600 aaaacaggtc tgattacaac aacttcaagg aaattggatc
gagaacagca ggcagaacat 3660 tttctggagg tgactgtgac agatggtggt
ccctctccaa aacagtcaac catttgggtg 3720 gtggttcagg ttctagatga
aaatgacaac aagccccagt tcccagagaa ggtctaccag 3780 atcaagctgc
cagaacgtga ccgaaagaag agaggagaac cgatttacag ggcttttgca 3840
tttgatagag atgagggccc caacgcagaa atctcctaca gtattgtgga tgggaatgat
3900 gacggaaagt tctttattga ccctaaaact gggatggttt cttctagaaa
gcagtttaca 3960 gcaggcagtt atgacatcct aacgataaag gcagtggaca
atgggcgccc acagaaatcc 4020 tccacggccc gcctccacat tgaatggatt
aagaaaccac ccccttcacc tataccattg 4080 accttcgatg agccgtttta
taacttcaca gtcatggaaa gtgatagagt gactgaaatt 4140 gtaggggtgg
tgtctgtgca gccagctaac acccctctgt ggtttgacat agttgggggg 4200
aattttgaca gcgcttttga tgcagagaag ggtgttggga caattgtcat cgcaaaacct
4260 ttggatgcag agcagaggtc catctataat atgagtgtgg aagtcaccga
tgggacaaat 4320 gttgctgtta ctcaggtatt tatcaaagtg ctggataata
atgataatgg cccagaattc 4380 tctcagccga attacgatgt gacaatttcc
gaggatgtgc ttccagacac ggagatcctg 4440 cagattgaag ccacagatag
agatgagaag cacaagctga gctacactgt tcatagcagc 4500 atcgactcca
tcagcatgag aaaattccgg attgacccta gcactggcgt gctctatact 4560
gccgagaggc tggaccatga ggcccaggac aagcacattc tcaacataat ggtcagagat
4620 caggagtttc cttatcgaag aaacttggcc cgagtcattg tgaatgtgga
ggatgctaat 4680 gatcacagtc cttattttac caacccactg tatgaagcgt
ctgtgtttga atctgctgct 4740 ctgggatcag ctgttctgca agtgacggct
ctggacaaag acaaaggaga aaatgcagaa 4800 ctcatatata ccatagaagc
agggaacact gggaacatgt ttaagatcga accggtccta 4860 ggcatcatca
ccatttgcaa agaaccagac atgacgacga tgggtcagtt tgtcctatcc 4920
atcaaagtca cagatcaggg atccccgcca atgtctgcta ctgcaattgt gcgcatttcc
4980 gtcaccatgt ctgacaattc tcaccccaag ttcattcaca aagactacca
agcagaagta 5040 aatgaaaatg ttgacattgg aacatcagtc attctaatct
ctgccatcag tcaatctacc 5100 ctcatttatg aagtcaaaga tggagacatt
aatgggatct ttaccataaa tccatattct 5160 ggagtcatca ccactcagaa
ggccctggat tatgagcgca catcctctta tcaactcatc 5220 attcaggcca
ccaatatggc aggaatggct tccaatgcta cagtcaatat tcagattgtt 5280
gatgaaaatg ataatgcccc agtttttctc ttttctcaat actcaggcag cctaagtgag
5340 gctgccccaa ttaatagcat tgtcaggagc ttggataaca gcccactggt
gattcgagcc 5400 acagatgctg acagcaaccg gaatgctctg cttgtgtatc
agattgtgga gtcaacagca 5460 aaaaagtttt tcacggtgga ctccagtaca
ggtgcaatca gaacaattgc caacctggac 5520 catgaaacca ttgcccattt
ccattttcat gtgcatgtga gagacagtgg tagcccccaa 5580 ctgactgcag
agagtcccgt tgaagtcaac attgaggtga cagatgtgaa tgataaccca 5640
cctgttttta ctcaggctgt gtttgagact atcttacttc tacctaccta tgttggagtg
5700 gaggttctga aagttagtgc cacagatcct gactctgagg taccccctga
actgacatac 5760 agcctaatgg aaggcagttt ggatcatttt ttaattgact
caaacagtgg agtacttacc 5820 ataaaaaaca acaacctctc caaggatcac
tacatgctga tagttaaggt gtctgatgga 5880 aagttctaca gtacctccat
ggtcaccatc atggttaaag aagccatgga cagcggcctc 5940 cactttacac
aaagcttcta ttccacctca atctcagaga acaacactaa cataaccaaa 6000
gttgctattg tcaatgcagt tggaaatcgc cttaatgagc ccttaaaata cagcatctta
6060 aacccaggaa ataagttcaa gataaaatct acctcagggg tcattcagac
gactggagtc 6120 ccctttgacc gtgaagaaca agagttatat gagctggtgg
tagaagccag ccgtgagctg 6180 gaccatctgc gtgtggccag agtggtggtc
agggttaaca ttgaagacat aaatgacaat 6240 tctccagtct ttgtgggcct
cccatactat gctgctgttc aagtggatgc ggaacccggg 6300 actctgattt
atcaggtgac agccattgac aaagataaag gtccaaatgg agaagtgacc 6360
tatgtcctgc aggatgacta tggccacttt gaaattaacc ctaattcagg gaatgttatt
6420 ttaaaggaag cattcaactc tgacttgtcc aacattgagt atggagtcac
catcctagcc 6480 aaggatggcg gaaaaccttc tttgtctaca tctgtggagc
ttcccatcac tattgtcaac 6540 aaagcaatgc ctgtgtttga taagcccttt
tatacagcat ctgtcaatga agacatcaga 6600 atgaacacac ccatcctaag
catcaatgcc accagtccag aaggccaagg catcatatat 6660 atcattatcg
atggggaccc ttttaaacag tttaacattg actttgacac tggggtcctg 6720
aaagttgtta gccctttgga ttatgaagtt acatctgctt acaagctgac aataagagcc
6780 agcgacgccc ttactggtgc tagggctgaa gtcactgttg acttgctagt
taatgatgta 6840 aatgacaacc cccctatttt cgatcagcct acatacaata
caacactatc agaagcatct 6900 cttattggga cacctgtttt acaagttgtc
tctattgatg cagactcaga aaacaataaa 6960 atggtacatt atcagattgt
ccaggatacc tacaatagca cagattattt tcacatagat 7020 agctcaagtg
gcttaatcct gacagcacga atgctggacc atgagttagt acaacactgc 7080
actttgaaag tcagatcaat agatagtggc ttcccatcac tgagcagtga ggttctcgtt
7140 catatctaca tctctgatgt aaatgacaac cctccagttt ttaatcagct
catttatgag 7200 tcatatgtga gtgaattagc cccccggggc cattttgtaa
cctgtgtaca agcctctgat 7260 gcagacagct ctgattttga ccggttggaa
tatagcattt tatctgggaa tgaccggacg 7320 agctttctga tggacagcaa
gagtggagtt atcacattgt ccaaccatcg gaagcagcgg 7380 atggagcctc
tgtacagtct caatgtgtct gtctctgatg ggttgttcac cagcactgca 7440
caggtgcata ttagggtact tggggctaac ttgtacagcc ctgccttttc acaaagcaca
7500 tacgtagctg aggtgagaga gaacgtggct gcaggaacaa aggtaattca
tgttcgagcc 7560 acagatggtg atccagggac ttatgggcag atcagctatg
ccatcatcaa tgactttgcc 7620 aaggatcgat tcctcataga cagcaatggg
caggtcatca ccacagaaag gctagaccgg 7680 gaaaaccctc tagaagggga
tgttagtatt tttgtgaggg cccttgatgg tggagggaga 7740 acaactttct
gcactgtgag agtgattgtt gtggatgaaa atgacaatgc tccccagttc 7800
atgacagtgg aatatagagc cagtgtcagg gcagatgttg gaaggggcca cttggtcact
7860 caagttcaag ccatagatcc cgatgatgga gcaaattcaa ggattactta
ttccctctat 7920 agcgaggcct ctgtttcagt ggccgacctc ctggaaatcg
atcctgacaa tggctggatg 7980 gtcacaaagg gtaattttaa ccagctgaaa
aatacagtgc tttcgttctt tgtcaaagca 8040 gtagatgggg gcatcccagt
aaagcactcc ctcattcctg tctatatcca cgtcttgccc 8100 cctgaaacgt
tcttgccatc attcacccag tctcagtatt cctttaccat tgcagaagat 8160
acagccattg ggagtacagt ggacaccctg aggattttgc ccagtcagaa tgtctggttc
8220 agcacagtta atggggaacg gccagaaaat aacaaagggg gcgtattcgt
catagaacag 8280 gaaacaggca ctattaagct tgacaaacgc cttgaccgtg
aaaccagccc agctttccac 8340 tttaaagtag cagccactat acccctggac
aaagtagaca ttgtgtttac tgtggatgta 8400 gatatcaagg tattggattt
gaatgacaac aagccagtct ttgaaacttc aagctatgac 8460 accattataa
tggaagggat gcctgttggc accaaactca cacaagtgag agctattgat 8520
atggactggg gagccaatgg acaagtcact tactccctcc actcggattc ccagcccgaa
8580 aaggtaatgg aagcattcaa tattgacagc aacacgggct ggatcagtac
cttgaaggac 8640 ctagatcacg agacagaccc cacattcacc ttctctgtgg
tggcctctga ccttggagag 8700 gcattctctc tttcctccac ggccttggtc
tctgtcagag tgacagatat aaatgacaat 8760 gcaccagtct tcgcgcagga
agtgtaccga gggaatgtga aggagagcga cccaccgggc 8820 gaggtggtag
ccgtcctcag cacctgggac agagacacat ccgacgttaa tcgccaagtg 8880
agctaccata ttacaggagg aaaccctcga ggaaggtttg ctctgggcct ggtgcaaagt
8940 gagtggaagg tctatgtgaa gaggcctcta gacagagaag aacaggacat
ttactttctc 9000 aatatcactg ccactgatgg gctttttgtc acacaggcca
tggtggaagt gagcgtcagt 9060 gatgtgaatg acaatagccc agtgtgtgat
caggttgcat atacagcatt acttcctgaa 9120 gacattccat caaataaaat
catcctgaaa gtcagtgcaa aggatgctga tattggatcc 9180 aatggatata
tacgatactc actctatgga tctggaaaca gtgaattttt tctagatcca 9240
gaaagtggcg agttaaaaac cttggctctg ttggaccggg agaggatccc cgtgtacagc
9300 ctgatggcca aggccactga cgggggtggc aggttctgcc agtccaacat
ccacctaatc 9360 ctggaggatg tgaatgataa cccccctgtg ttttcttctg
accactacaa cacctgtgtc 9420 tatgagaaca cagccaccaa ggctctgttg
accagagttc aagccgtgga ccccgacatt 9480 ggcatcaata ggaaggtcgt
gtactccctg gcagactcag ctggtggggt cttctccatt 9540 gacagctcat
ctggcatcat catcctggag cagccactgg accgtgagca gcagtcttcg 9600
tacaacatca gcgtgcgggc cactgaccag agtcctggac agtccctgtc ctctctcact
9660 actgtcacca tcaccgttct ggacattaat gacaaccccc ctgtgtttga
gaggagggac 9720 tacctggtga cggtgcctga ggacacctcc cctggcaccc
aagtccttgc tgtttttgcc 9780 accagcaaag atattggcac aaatgctgag
atcacttatc tcatccggtc tgggaacgaa 9840 caagggaaat ttaagatcaa
ccccaagaca gggggtattt ctgtctctga agtcctggac 9900 tatgaattat
gcaaaaggtt ttacctggta gtggaagcca aagatggggg caccccagct 9960
ctcagcgctg tggccactgt caacatcaac ctcacagatg ttaatgacaa ccctcccaag
10020 ttcagccaag acgtctacag tgcggttatc agtgaagacg ccttggtggg
agactctgtc 10080 attttgctaa tagcagaaga tgtagacagc cagcccaacg
gacagattca tttttccatt 10140 gtgaatggag atcgggacaa tgaatttact
gtagatcctg tcttgggact tgtgaaagtt 10200 aagaagaaat tggaccggga
acgggtgtct ggatactctc tgcttgtcca ggccgtagac 10260 agtggcattc
ctgcaatgtc atcaactgca actgtcaaca ttgatatttc tgatgtgaat 10320
gacaacagcc cggtgtttac acctgccaac tatactgctg tgattcagga aaataagcca
10380 gtgggcacca gcatcttgca gctggtggtg acagacagag actcctttca
caatgggcct 10440 cccttttcat tctctatttt gtcgggaaat gaagaggagg
agtttgtgtt ggaccctcat 10500 gggatcttgc ggtcggctgt ggtcttccag
cacacagagt ctctggaata cgtgttgtgt 10560 gtccaggcaa aggattcagg
caaaccccag caagtttctc acacttacat ccgcgtgcga 10620 gtcattgagg
aaagcaccca caagcccaca gccattcccc tggaaatttt cattgtcacc 10680
atggaggatg actttcctgg tggggtcatt gggaagattc atgccacaga tcaagacatg
10740 tatgatgtgc tcacatttgc cctgaaatcg gagcagaaaa gcttatttaa
agtgaacagt 10800 cacgatggga aaatcatcgc cctgggaggc ctggacagcg
gcaagtatgt cctgaatgtg 10860 tctgtgagtg atggtcgctt ccaggtaccc
attgatgtgg tcgtgcatgt ggagcagttg 10920 gtgcatgaga tgctgcagaa
cactgtcacc atccgctttg aaaatgtgtc ccctgaggac 10980 ttcgtggggc
tgcacatgca tgggttccgg cgcaccctgc ggaatgcagt cctcacccag 11040
aagcaggaca gcctgcgcat catcagcatc cagcccgtgg caggcaccaa ccaactggac
11100 atgctgtttg cggtggagat gcacagcagc gagttctaca agccagccta
cctgatccag 11160 aagctgtcca atgctagaag acacctggag aatatcatgc
gcatctcagc catcttggag 11220 aagaactgct cagggctgga ctgtcaggaa
cagcattgtg agcaaggctt gtcactcgat 11280 tcccacgcgc tcatgaccta
cagcacggct cgcatcagct ttgtgtgtcc gcgtttctac 11340 aggaacgtgc
gttgcacctg caatggagga ctgtgtccgg ggtccaacga tccttgtgtg 11400
gagaagccgt gtccagggga catgcagtgt gtcggttatg aagccagcag gagaccgttc
11460 ctctgccagt gtccaccagg gaagctcgga gagtgctcag ggcacacttc
tctcagcttt 11520 gctggaaaca gttacatcaa atatcggctt tctgaaaata
gcaaagaaga ggatttcaaa 11580 ctagctctgc gtcttcgaac actgcaaagc
aatgggatta taatgtacac cagagcaaat 11640 ccctgcataa ttctgaagat
tgtggatggc aagctgtggt tccagctgga ctgcggcagc 11700 ggccctggaa
tcttgggcat ctcgggccgt gctgtcaacg acgggagctg gcactcggtc 11760
ttcctggagc tcaaccgcaa tttcacgagc ctgtccctgg atgacagcta cgtggagcgg
11820 cgccgggcgc ccctctactt ccagacgctg agcactgaga gtagcatcta
cttcggcgcc 11880 ctggtgcaag cggataacat ccgcagcctg actgacacgc
gggtcacgca ggtgctcagc 11940 ggcttccagg gctgcctgga ctcggtgata
ctgaataaca atgagctgcc gctgcagaac 12000 aagcgcagca gcttcgcgga
ggtggtgggc ctgacggagc tgaagctggg ctgcgtgctc 12060 tatcccgacg
cctgcaagcg cagcccgtgc cagcacgggg gcagctgcac tggcctgcca 12120
tcggggggct atcagtgtac ctgtctctca cagtttacgg ggagaaactg tgaatctgag
12180 attacagcct gcttcccaaa cccctgccgg aatggaggat cctgcgatcc
aataggaaac 12240 actttcatct gcaattgtaa agctgggctc actggagtca
cgtgtgagga ggacatcaat 12300 gagtgcgaac gagaggagtg tgagaacgga
ggctcctgcg tgaacgtgtt cggctccttc 12360 ctctgcaact gcacgccggg
ctacgtgggc cagtactgcg ggcgccccgt ggtggtaccc 12420 aatatccagg
ctggccactc ctacgtgggg aaggaggagc tcatcggcat cgccgtggtc 12480
ctcttcgtca tcttcatcct ggtggttctc ttcatagtct tccgcaagaa ggtcttccgc
12540 aagaactact cccgcaacaa catcacgcta gtgcaggacc cggccaccgc
cgccctgctt 12600 aacaagagca atggcatccc gttccggaac ctgcgcggca
gtggggacgg ccgcaacgtc 12660 taccaggagg tggggccccc gcaggtcccc
gtgcgcccca tggcctacac accctgcttc 12720 cagagtgact ccaggagcaa
cctggataag atcgtggacg ggctgggagg cgagcaccag 12780 gaaatgacca
cgtttcaccc tgagtcgccc cgcatcctga cagcccggcg gggcgtggtc 12840
gtgtgcagtg tggcccccaa cctccccgcc gtgtcaccct gccgctccga ctgcgactcc
12900 atccggaaga atggctggga cgcgggaact gagaacaaag gggttgatga
cccgggagaa 12960 gtgacctgct ttgcaggtag taataaaggc agcaactctg
aagttcagtc cctcagctcc 13020 ttccagtcag attctggtga cgacaatgcc
tccatagtga ctgtcattca gcttgtcaac 13080 aatgtagttg acactataga
gaatgaagtg tctgtcatgg accaaggaca gaactacaac 13140 cgagcctatc
actgggacac ctctgattgg atgccagggg cccgcctgtc ggacatagag 13200
gaagtgccca actatgagaa ccaggatgga gggtctgcac accaggggag cacacgggag
13260 ctggagagcg attactacct gggtggttat gacattgaca gtgaataccc
accccctcat 13320 gaagaggagt tcttgagtca ggaccagctg cctcctcctc
tcccggagga cttcccagac 13380 caatatgagg ccctgccacc ctcccagcct
gtctccctgg ccagcacact gagcccagac 13440 tgcaggagaa ggccccagtt
tcatcctagc cagtatctcc ctcctcaccc attccccaac 13500 gaaacggatt
tggtgggccc gcctgccagc tgtgaattta gtacttttgc tgtgagcatg 13560
aaccagggca cagagcccac aggcccagca gacagcgtgt ctctgtcctt gcacaattcc
13620 agaggcacct catcctcgga tgtgtctgcc aactgcggct ttgacgattc
cgaagtagcc 13680 atgagtgact acgagagcgt gggagagctc agcctcgcca
gccttcacat tccctttgtg 13740 gagactcagc atcagactca agtgtag 13767 8
4588 PRT homo sapiens 8 Met Asp Ile Ile Met Gly His Cys Val Gly Thr
Arg Pro Pro Ala Cys 1 5 10 15 Cys Leu Ile Leu Leu Leu Phe Lys Leu
Leu Ala Thr Val Ser Gln Gly 20 25 30 Leu Pro Gly Thr Gly Pro Leu
Gly Phe His Phe Thr His Ser Ile Tyr 35 40 45 Asn Ala Thr Val Tyr
Glu Asn Ser Ala Ala Arg Thr Tyr Val Asn Ser 50 55 60 Gln Ser Arg
Met Gly Ile Thr Leu Ile Asp Leu Ser Trp Asp Ile Lys 65 70 75 80 Tyr
Arg Ile Val Ser Gly Asp Glu Glu Gly Phe Phe Lys Ala Glu Glu 85 90
95 Val Ile Ile Ala Asp Phe Cys Phe Leu Arg Ile Arg Thr Lys Gly Gly
100 105 110 Asn Ser Ala Ile Leu Asn Arg Glu Ile Gln Asp Asn Tyr Leu
Leu Ile 115 120 125 Val Lys Gly Ser Val Arg Gly Glu Asp Leu Glu Ala
Trp Thr Lys Val 130 135 140 Asn Ile Gln Val Leu Asp Met Asn Asp Leu
Arg Pro Leu Phe Ser Pro 145 150 155 160 Thr Thr Tyr Ser Val Thr Ile
Ala Glu Ser Thr Pro Leu Arg Thr Ser 165 170 175 Val Ala Gln Val Thr
Ala Thr Asp Ala Asp Ile Gly Ser Asn Gly Glu 180 185 190 Phe Tyr Tyr
Tyr Phe Lys Asn Lys Val Asp Leu Phe Ser Val His Pro 195 200 205
Thr Ser Gly Val Ile Ser Leu Ser Gly Arg Leu Asn Tyr Asp Glu Lys 210
215 220 Asn Arg Tyr Asp Leu Glu Ile Leu Ala Val Asp Arg Gly Met Lys
Leu 225 230 235 240 Tyr Gly Asn Asn Gly Val Ser Ser Thr Ala Lys Leu
Tyr Val His Ile 245 250 255 Glu Arg Ile Asn Glu His Ala Pro Thr Ile
His Val Val Thr His Val 260 265 270 Pro Phe Ser Leu Glu Lys Glu Pro
Thr Tyr Ala Val Val Thr Val Asp 275 280 285 Asp Leu Asp Asp Gly Ala
Asn Gly Glu Ile Glu Ser Val Ser Ile Val 290 295 300 Ala Gly Asp Pro
Leu Asp Gln Phe Phe Leu Ala Lys Glu Gly Lys Trp 305 310 315 320 Leu
Asn Glu Tyr Lys Ile Lys Glu Arg Lys Gln Ile Asp Trp Glu Ser 325 330
335 Phe Pro Tyr Gly Tyr Asn Leu Thr Leu Gln Ala Lys Asp Lys Gly Ser
340 345 350 Pro Gln Lys Cys Ser Ala Leu Lys Ala Val Tyr Ile Gly Asn
Pro Thr 355 360 365 Arg Asp Thr Val Pro Ile Arg Phe Glu Lys Glu Val
Tyr Asp Val Ser 370 375 380 Ile Ser Glu Phe Ser Pro Pro Gly Val Val
Val Ala Ile Val Lys Leu 385 390 395 400 Ser Pro Glu Pro Ile Asp Val
Glu Tyr Lys Leu Ser Pro Gly Glu Asp 405 410 415 Ala Val Tyr Phe Lys
Ile Asn Pro Arg Ser Gly Leu Ile Val Thr Ala 420 425 430 Arg Pro Leu
Asn Thr Val Lys Lys Glu Val Tyr Lys Leu Glu Val Thr 435 440 445 Asn
Lys Glu Gly Asp Leu Lys Ala Gln Val Thr Ile Ser Ile Glu Asp 450 455
460 Ala Asn Asp His Thr Pro Glu Phe Gln Gln Pro Leu Tyr Asp Ala Tyr
465 470 475 480 Val Asn Glu Ser Val Pro Val Gly Thr Ser Val Leu Thr
Val Ser Ala 485 490 495 Ser Asp Lys Asp Lys Gly Glu Asn Gly Tyr Ile
Thr Tyr Ser Ile Ala 500 505 510 Ser Leu Asn Leu Leu Pro Phe Val Ile
Asn Gln Phe Thr Gly Val Ile 515 520 525 Ser Thr Thr Glu Glu Leu Asp
Phe Glu Ser Ser Pro Glu Ile Tyr Arg 530 535 540 Phe Ile Val Arg Ala
Ser Asp Trp Gly Ser Pro Tyr Arg His Glu Ser 545 550 555 560 Glu Val
Asn Val Thr Ile Arg Ile Gly Asn Val Asn Asp Asn Ser Pro 565 570 575
Leu Phe Glu Lys Val Ala Cys Gln Gly Val Ile Ser Tyr Asp Phe Pro 580
585 590 Val Gly Gly His Ile Thr Ala Val Ser Ala Ile Asp Ile Asp Glu
Leu 595 600 605 Glu Leu Val Lys Tyr Lys Ile Ile Ser Gly Asn Glu Leu
Gly Phe Phe 610 615 620 Tyr Leu Asn Pro Asp Ser Gly Val Leu Gln Leu
Lys Lys Ser Leu Thr 625 630 635 640 Asn Ser Gly Ile Lys Asn Gly Asn
Phe Ala Leu Arg Ile Thr Ala Thr 645 650 655 Asp Gly Glu Asn Leu Ala
Asp Pro Met Ser Ile Asn Ile Ser Val Leu 660 665 670 His Gly Lys Val
Ser Ser Lys Ser Phe Ser Cys Arg Glu Thr Arg Val 675 680 685 Ala Gln
Lys Leu Ala Glu Lys Leu Leu Ile Lys Ala Lys Ala Asn Gly 690 695 700
Lys Leu Asn Leu Glu Asp Gly Phe Leu Asp Phe Tyr Ser Ile Asn Arg 705
710 715 720 Gln Gly Pro Tyr Phe Asp Lys Ser Phe Pro Ser Asp Val Ala
Val Lys 725 730 735 Glu Asp Leu Pro Val Gly Ala Asn Ile Leu Lys Ile
Lys Ala Tyr Asp 740 745 750 Ala Asp Ser Gly Phe Asn Gly Lys Val Leu
Phe Thr Ile Ser Asp Gly 755 760 765 Asn Thr Asp Ser Cys Phe Asn Ile
Asp Met Glu Thr Gly Gln Leu Lys 770 775 780 Val Leu Met Pro Met Asp
Arg Glu His Thr Asp Leu Tyr Leu Leu Asn 785 790 795 800 Ile Thr Ile
Tyr Asp Leu Gly Asn Pro Gln Lys Ser Ser Trp Arg Leu 805 810 815 Leu
Thr Ile Asn Val Glu Asp Ala Asn Asp Asn Ser Pro Val Phe Ile 820 825
830 Gln Asp Ser Tyr Ser Val Asn Ile Leu Glu Ser Ser Gly Ile Gly Thr
835 840 845 Glu Ile Ile Gln Val Glu Ala Arg Asp Lys Asp Leu Gly Ser
Asn Gly 850 855 860 Glu Val Thr Tyr Ser Val Leu Thr Asp Thr Gln Gln
Phe Ala Ile Asn 865 870 875 880 Ser Ser Thr Gly Ile Val Tyr Val Ala
Asp Gln Leu Asp Arg Glu Ser 885 890 895 Lys Ala Asn Tyr Ser Leu Lys
Ile Glu Ala Arg Asp Lys Ala Glu Ser 900 905 910 Gly Gln Gln Leu Phe
Ser Val Val Thr Leu Lys Val Phe Leu Asp Asp 915 920 925 Val Asn Asp
Cys Ser Pro Ala Phe Ile Pro Ser Ser Tyr Ser Val Lys 930 935 940 Val
Leu Glu Asp Leu Pro Val Gly Thr Val Ile Ala Trp Leu Glu Thr 945 950
955 960 His Asp Pro Asp Leu Gly Leu Gly Gly Gln Val Arg Tyr Ser Leu
Val 965 970 975 Asn Asp Tyr Asn Gly Arg Phe Glu Ile Asp Lys Ala Ser
Gly Ala Ile 980 985 990 Arg Leu Ser Lys Glu Leu Asp Tyr Glu Lys Gln
Gln Phe Tyr Asn Leu 995 1000 1005 Thr Val Arg Ala Lys Asp Lys Gly
Arg Pro Val Ser Leu Ser Ser Val 1010 1015 1020 Ser Phe Val Glu Val
Glu Val Val Asp Val Asn Glu Asn Leu His Thr 1025 1030 1035 1040 Pro
Tyr Phe Pro Asp Phe Ala Val Val Gly Ser Val Lys Glu Asn Ser 1045
1050 1055 Arg Ile Gly Thr Ser Val Leu Gln Val Thr Ala Arg Asp Glu
Asp Ser 1060 1065 1070 Gly Arg Asp Gly Glu Ile Gln Tyr Ser Ile Arg
Asp Gly Ser Gly Leu 1075 1080 1085 Gly Arg Phe Ser Ile Asp Asp Glu
Ser Gly Val Ile Thr Ala Ala Asp 1090 1095 1100 Ile Leu Asp Arg Glu
Thr Met Gly Ser Tyr Trp Leu Thr Val Tyr Ala 1105 1110 1115 1120 Thr
Asp Arg Gly Val Val Pro Leu Tyr Ser Thr Ile Glu Val Tyr Ile 1125
1130 1135 Glu Val Glu Asp Val Asn Asp Asn Ala Pro Leu Thr Ser Glu
Pro Ile 1140 1145 1150 Tyr Tyr Pro Val Val Met Glu Asn Ser Pro Lys
Asp Val Ser Val Ile 1155 1160 1165 Gln Ile Gln Ala Glu Asp Pro Asp
Ser Ser Ser Asn Glu Lys Leu Thr 1170 1175 1180 Tyr Arg Ile Thr Ser
Gly Asn Pro Gln Asn Phe Phe Ala Ile Asn Ile 1185 1190 1195 1200 Lys
Thr Gly Leu Ile Thr Thr Thr Ser Arg Lys Leu Asp Arg Glu Gln 1205
1210 1215 Gln Ala Glu His Phe Leu Glu Val Thr Val Thr Asp Gly Gly
Pro Ser 1220 1225 1230 Pro Lys Gln Ser Thr Ile Trp Val Val Val Gln
Val Leu Asp Glu Asn 1235 1240 1245 Asp Asn Lys Pro Gln Phe Pro Glu
Lys Val Tyr Gln Ile Lys Leu Pro 1250 1255 1260 Glu Arg Asp Arg Lys
Lys Arg Gly Glu Pro Ile Tyr Arg Ala Phe Ala 1265 1270 1275 1280 Phe
Asp Arg Asp Glu Gly Pro Asn Ala Glu Ile Ser Tyr Ser Ile Val 1285
1290 1295 Asp Gly Asn Asp Asp Gly Lys Phe Phe Ile Asp Pro Lys Thr
Gly Met 1300 1305 1310 Val Ser Ser Arg Lys Gln Phe Thr Ala Gly Ser
Tyr Asp Ile Leu Thr 1315 1320 1325 Ile Lys Ala Val Asp Asn Gly Arg
Pro Gln Lys Ser Ser Thr Ala Arg 1330 1335 1340 Leu His Ile Glu Trp
Ile Lys Lys Pro Pro Pro Ser Pro Ile Pro Leu 1345 1350 1355 1360 Thr
Phe Asp Glu Pro Phe Tyr Asn Phe Thr Val Met Glu Ser Asp Arg 1365
1370 1375 Val Thr Glu Ile Val Gly Val Val Ser Val Gln Pro Ala Asn
Thr Pro 1380 1385 1390 Leu Trp Phe Asp Ile Val Gly Gly Asn Phe Asp
Ser Ala Phe Asp Ala 1395 1400 1405 Glu Lys Gly Val Gly Thr Ile Val
Ile Ala Lys Pro Leu Asp Ala Glu 1410 1415 1420 Gln Arg Ser Ile Tyr
Asn Met Ser Val Glu Val Thr Asp Gly Thr Asn 1425 1430 1435 1440 Val
Ala Val Thr Gln Val Phe Ile Lys Val Leu Asp Asn Asn Asp Asn 1445
1450 1455 Gly Pro Glu Phe Ser Gln Pro Asn Tyr Asp Val Thr Ile Ser
Glu Asp 1460 1465 1470 Val Leu Pro Asp Thr Glu Ile Leu Gln Ile Glu
Ala Thr Asp Arg Asp 1475 1480 1485 Glu Lys His Lys Leu Ser Tyr Thr
Val His Ser Ser Ile Asp Ser Ile 1490 1495 1500 Ser Met Arg Lys Phe
Arg Ile Asp Pro Ser Thr Gly Val Leu Tyr Thr 1505 1510 1515 1520 Ala
Glu Arg Leu Asp His Glu Ala Gln Asp Lys His Ile Leu Asn Ile 1525
1530 1535 Met Val Arg Asp Gln Glu Phe Pro Tyr Arg Arg Asn Leu Ala
Arg Val 1540 1545 1550 Ile Val Asn Val Glu Asp Ala Asn Asp His Ser
Pro Tyr Phe Thr Asn 1555 1560 1565 Pro Leu Tyr Glu Ala Ser Val Phe
Glu Ser Ala Ala Leu Gly Ser Ala 1570 1575 1580 Val Leu Gln Val Thr
Ala Leu Asp Lys Asp Lys Gly Glu Asn Ala Glu 1585 1590 1595 1600 Leu
Ile Tyr Thr Ile Glu Ala Gly Asn Thr Gly Asn Met Phe Lys Ile 1605
1610 1615 Glu Pro Val Leu Gly Ile Ile Thr Ile Cys Lys Glu Pro Asp
Met Thr 1620 1625 1630 Thr Met Gly Gln Phe Val Leu Ser Ile Lys Val
Thr Asp Gln Gly Ser 1635 1640 1645 Pro Pro Met Ser Ala Thr Ala Ile
Val Arg Ile Ser Val Thr Met Ser 1650 1655 1660 Asp Asn Ser His Pro
Lys Phe Ile His Lys Asp Tyr Gln Ala Glu Val 1665 1670 1675 1680 Asn
Glu Asn Val Asp Ile Gly Thr Ser Val Ile Leu Ile Ser Ala Ile 1685
1690 1695 Ser Gln Ser Thr Leu Ile Tyr Glu Val Lys Asp Gly Asp Ile
Asn Gly 1700 1705 1710 Ile Phe Thr Ile Asn Pro Tyr Ser Gly Val Ile
Thr Thr Gln Lys Ala 1715 1720 1725 Leu Asp Tyr Glu Arg Thr Ser Ser
Tyr Gln Leu Ile Ile Gln Ala Thr 1730 1735 1740 Asn Met Ala Gly Met
Ala Ser Asn Ala Thr Val Asn Ile Gln Ile Val 1745 1750 1755 1760 Asp
Glu Asn Asp Asn Ala Pro Val Phe Leu Phe Ser Gln Tyr Ser Gly 1765
1770 1775 Ser Leu Ser Glu Ala Ala Pro Ile Asn Ser Ile Val Arg Ser
Leu Asp 1780 1785 1790 Asn Ser Pro Leu Val Ile Arg Ala Thr Asp Ala
Asp Ser Asn Arg Asn 1795 1800 1805 Ala Leu Leu Val Tyr Gln Ile Val
Glu Ser Thr Ala Lys Lys Phe Phe 1810 1815 1820 Thr Val Asp Ser Ser
Thr Gly Ala Ile Arg Thr Ile Ala Asn Leu Asp 1825 1830 1835 1840 His
Glu Thr Ile Ala His Phe His Phe His Val His Val Arg Asp Ser 1845
1850 1855 Gly Ser Pro Gln Leu Thr Ala Glu Ser Pro Val Glu Val Asn
Ile Glu 1860 1865 1870 Val Thr Asp Val Asn Asp Asn Pro Pro Val Phe
Thr Gln Ala Val Phe 1875 1880 1885 Glu Thr Ile Leu Leu Leu Pro Thr
Tyr Val Gly Val Glu Val Leu Lys 1890 1895 1900 Val Ser Ala Thr Asp
Pro Asp Ser Glu Val Pro Pro Glu Leu Thr Tyr 1905 1910 1915 1920 Ser
Leu Met Glu Gly Ser Leu Asp His Phe Leu Ile Asp Ser Asn Ser 1925
1930 1935 Gly Val Leu Thr Ile Lys Asn Asn Asn Leu Ser Lys Asp His
Tyr Met 1940 1945 1950 Leu Ile Val Lys Val Ser Asp Gly Lys Phe Tyr
Ser Thr Ser Met Val 1955 1960 1965 Thr Ile Met Val Lys Glu Ala Met
Asp Ser Gly Leu His Phe Thr Gln 1970 1975 1980 Ser Phe Tyr Ser Thr
Ser Ile Ser Glu Asn Asn Thr Asn Ile Thr Lys 1985 1990 1995 2000 Val
Ala Ile Val Asn Ala Val Gly Asn Arg Leu Asn Glu Pro Leu Lys 2005
2010 2015 Tyr Ser Ile Leu Asn Pro Gly Asn Lys Phe Lys Ile Lys Ser
Thr Ser 2020 2025 2030 Gly Val Ile Gln Thr Thr Gly Val Pro Phe Asp
Arg Glu Glu Gln Glu 2035 2040 2045 Leu Tyr Glu Leu Val Val Glu Ala
Ser Arg Glu Leu Asp His Leu Arg 2050 2055 2060 Val Ala Arg Val Val
Val Arg Val Asn Ile Glu Asp Ile Asn Asp Asn 2065 2070 2075 2080 Ser
Pro Val Phe Val Gly Leu Pro Tyr Tyr Ala Ala Val Gln Val Asp 2085
2090 2095 Ala Glu Pro Gly Thr Leu Ile Tyr Gln Val Thr Ala Ile Asp
Lys Asp 2100 2105 2110 Lys Gly Pro Asn Gly Glu Val Thr Tyr Val Leu
Gln Asp Asp Tyr Gly 2115 2120 2125 His Phe Glu Ile Asn Pro Asn Ser
Gly Asn Val Ile Leu Lys Glu Ala 2130 2135 2140 Phe Asn Ser Asp Leu
Ser Asn Ile Glu Tyr Gly Val Thr Ile Leu Ala 2145 2150 2155 2160 Lys
Asp Gly Gly Lys Pro Ser Leu Ser Thr Ser Val Glu Leu Pro Ile 2165
2170 2175 Thr Ile Val Asn Lys Ala Met Pro Val Phe Asp Lys Pro Phe
Tyr Thr 2180 2185 2190 Ala Ser Val Asn Glu Asp Ile Arg Met Asn Thr
Pro Ile Leu Ser Ile 2195 2200 2205 Asn Ala Thr Ser Pro Glu Gly Gln
Gly Ile Ile Tyr Ile Ile Ile Asp 2210 2215 2220 Gly Asp Pro Phe Lys
Gln Phe Asn Ile Asp Phe Asp Thr Gly Val Leu 2225 2230 2235 2240 Lys
Val Val Ser Pro Leu Asp Tyr Glu Val Thr Ser Ala Tyr Lys Leu 2245
2250 2255 Thr Ile Arg Ala Ser Asp Ala Leu Thr Gly Ala Arg Ala Glu
Val Thr 2260 2265 2270 Val Asp Leu Leu Val Asn Asp Val Asn Asp Asn
Pro Pro Ile Phe Asp 2275 2280 2285 Gln Pro Thr Tyr Asn Thr Thr Leu
Ser Glu Ala Ser Leu Ile Gly Thr 2290 2295 2300 Pro Val Leu Gln Val
Val Ser Ile Asp Ala Asp Ser Glu Asn Asn Lys 2305 2310 2315 2320 Met
Val His Tyr Gln Ile Val Gln Asp Thr Tyr Asn Ser Thr Asp Tyr 2325
2330 2335 Phe His Ile Asp Ser Ser Ser Gly Leu Ile Leu Thr Ala Arg
Met Leu 2340 2345 2350 Asp His Glu Leu Val Gln His Cys Thr Leu Lys
Val Arg Ser Ile Asp 2355 2360 2365 Ser Gly Phe Pro Ser Leu Ser Ser
Glu Val Leu Val His Ile Tyr Ile 2370 2375 2380 Ser Asp Val Asn Asp
Asn Pro Pro Val Phe Asn Gln Leu Ile Tyr Glu 2385 2390 2395 2400 Ser
Tyr Val Ser Glu Leu Ala Pro Arg Gly His Phe Val Thr Cys Val 2405
2410 2415 Gln Ala Ser Asp Ala Asp Ser Ser Asp Phe Asp Arg Leu Glu
Tyr Ser 2420 2425 2430 Ile Leu Ser Gly Asn Asp Arg Thr Ser Phe Leu
Met Asp Ser Lys Ser 2435 2440 2445 Gly Val Ile Thr Leu Ser Asn His
Arg Lys Gln Arg Met Glu Pro Leu 2450 2455 2460 Tyr Ser Leu Asn Val
Ser Val Ser Asp Gly Leu Phe Thr Ser Thr Ala 2465 2470 2475 2480 Gln
Val His Ile Arg Val Leu Gly Ala Asn Leu Tyr Ser Pro Ala Phe 2485
2490 2495 Ser Gln Ser Thr Tyr Val Ala Glu Val Arg Glu Asn Val Ala
Ala Gly 2500 2505 2510 Thr Lys Val Ile His Val Arg Ala Thr Asp Gly
Asp Pro Gly Thr Tyr 2515 2520 2525 Gly Gln Ile Ser Tyr Ala Ile Ile
Asn Asp Phe Ala Lys Asp Arg Phe 2530 2535 2540 Leu Ile Asp Ser Asn
Gly Gln Val Ile Thr Thr Glu Arg Leu Asp Arg 2545 2550 2555 2560 Glu
Asn Pro Leu Glu Gly Asp Val Ser Ile Phe Val Arg Ala Leu Asp 2565
2570 2575 Gly Gly Gly Arg Thr Thr Phe Cys Thr Val Arg Val Ile Val
Val Asp 2580 2585 2590 Glu Asn Asp Asn Ala Pro Gln Phe Met Thr Val
Glu Tyr Arg Ala Ser 2595 2600 2605 Val Arg Ala Asp Val Gly Arg Gly
His Leu Val Thr Gln Val Gln Ala 2610 2615 2620 Ile Asp Pro Asp Asp
Gly Ala Asn Ser Arg Ile Thr Tyr Ser
Leu Tyr 2625 2630 2635 2640 Ser Glu Ala Ser Val Ser Val Ala Asp Leu
Leu Glu Ile Asp Pro Asp 2645 2650 2655 Asn Gly Trp Met Val Thr Lys
Gly Asn Phe Asn Gln Leu Lys Asn Thr 2660 2665 2670 Val Leu Ser Phe
Phe Val Lys Ala Val Asp Gly Gly Ile Pro Val Lys 2675 2680 2685 His
Ser Leu Ile Pro Val Tyr Ile His Val Leu Pro Pro Glu Thr Phe 2690
2695 2700 Leu Pro Ser Phe Thr Gln Ser Gln Tyr Ser Phe Thr Ile Ala
Glu Asp 2705 2710 2715 2720 Thr Ala Ile Gly Ser Thr Val Asp Thr Leu
Arg Ile Leu Pro Ser Gln 2725 2730 2735 Asn Val Trp Phe Ser Thr Val
Asn Gly Glu Arg Pro Glu Asn Asn Lys 2740 2745 2750 Gly Gly Val Phe
Val Ile Glu Gln Glu Thr Gly Thr Ile Lys Leu Asp 2755 2760 2765 Lys
Arg Leu Asp Arg Glu Thr Ser Pro Ala Phe His Phe Lys Val Ala 2770
2775 2780 Ala Thr Ile Pro Leu Asp Lys Val Asp Ile Val Phe Thr Val
Asp Val 2785 2790 2795 2800 Asp Ile Lys Val Leu Asp Leu Asn Asp Asn
Lys Pro Val Phe Glu Thr 2805 2810 2815 Ser Ser Tyr Asp Thr Ile Ile
Met Glu Gly Met Pro Val Gly Thr Lys 2820 2825 2830 Leu Thr Gln Val
Arg Ala Ile Asp Met Asp Trp Gly Ala Asn Gly Gln 2835 2840 2845 Val
Thr Tyr Ser Leu His Ser Asp Ser Gln Pro Glu Lys Val Met Glu 2850
2855 2860 Ala Phe Asn Ile Asp Ser Asn Thr Gly Trp Ile Ser Thr Leu
Lys Asp 2865 2870 2875 2880 Leu Asp His Glu Thr Asp Pro Thr Phe Thr
Phe Ser Val Val Ala Ser 2885 2890 2895 Asp Leu Gly Glu Ala Phe Ser
Leu Ser Ser Thr Ala Leu Val Ser Val 2900 2905 2910 Arg Val Thr Asp
Ile Asn Asp Asn Ala Pro Val Phe Ala Gln Glu Val 2915 2920 2925 Tyr
Arg Gly Asn Val Lys Glu Ser Asp Pro Pro Gly Glu Val Val Ala 2930
2935 2940 Val Leu Ser Thr Trp Asp Arg Asp Thr Ser Asp Val Asn Arg
Gln Val 2945 2950 2955 2960 Ser Tyr His Ile Thr Gly Gly Asn Pro Arg
Gly Arg Phe Ala Leu Gly 2965 2970 2975 Leu Val Gln Ser Glu Trp Lys
Val Tyr Val Lys Arg Pro Leu Asp Arg 2980 2985 2990 Glu Glu Gln Asp
Ile Tyr Phe Leu Asn Ile Thr Ala Thr Asp Gly Leu 2995 3000 3005 Phe
Val Thr Gln Ala Met Val Glu Val Ser Val Ser Asp Val Asn Asp 3010
3015 3020 Asn Ser Pro Val Cys Asp Gln Val Ala Tyr Thr Ala Leu Leu
Pro Glu 3025 3030 3035 3040 Asp Ile Pro Ser Asn Lys Ile Ile Leu Lys
Val Ser Ala Lys Asp Ala 3045 3050 3055 Asp Ile Gly Ser Asn Gly Tyr
Ile Arg Tyr Ser Leu Tyr Gly Ser Gly 3060 3065 3070 Asn Ser Glu Phe
Phe Leu Asp Pro Glu Ser Gly Glu Leu Lys Thr Leu 3075 3080 3085 Ala
Leu Leu Asp Arg Glu Arg Ile Pro Val Tyr Ser Leu Met Ala Lys 3090
3095 3100 Ala Thr Asp Gly Gly Gly Arg Phe Cys Gln Ser Asn Ile His
Leu Ile 3105 3110 3115 3120 Leu Glu Asp Val Asn Asp Asn Pro Pro Val
Phe Ser Ser Asp His Tyr 3125 3130 3135 Asn Thr Cys Val Tyr Glu Asn
Thr Ala Thr Lys Ala Leu Leu Thr Arg 3140 3145 3150 Val Gln Ala Val
Asp Pro Asp Ile Gly Ile Asn Arg Lys Val Val Tyr 3155 3160 3165 Ser
Leu Ala Asp Ser Ala Gly Gly Val Phe Ser Ile Asp Ser Ser Ser 3170
3175 3180 Gly Ile Ile Ile Leu Glu Gln Pro Leu Asp Arg Glu Gln Gln
Ser Ser 3185 3190 3195 3200 Tyr Asn Ile Ser Val Arg Ala Thr Asp Gln
Ser Pro Gly Gln Ser Leu 3205 3210 3215 Ser Ser Leu Thr Thr Val Thr
Ile Thr Val Leu Asp Ile Asn Asp Asn 3220 3225 3230 Pro Pro Val Phe
Glu Arg Arg Asp Tyr Leu Val Thr Val Pro Glu Asp 3235 3240 3245 Thr
Ser Pro Gly Thr Gln Val Leu Ala Val Phe Ala Thr Ser Lys Asp 3250
3255 3260 Ile Gly Thr Asn Ala Glu Ile Thr Tyr Leu Ile Arg Ser Gly
Asn Glu 3265 3270 3275 3280 Gln Gly Lys Phe Lys Ile Asn Pro Lys Thr
Gly Gly Ile Ser Val Ser 3285 3290 3295 Glu Val Leu Asp Tyr Glu Leu
Cys Lys Arg Phe Tyr Leu Val Val Glu 3300 3305 3310 Ala Lys Asp Gly
Gly Thr Pro Ala Leu Ser Ala Val Ala Thr Val Asn 3315 3320 3325 Ile
Asn Leu Thr Asp Val Asn Asp Asn Pro Pro Lys Phe Ser Gln Asp 3330
3335 3340 Val Tyr Ser Ala Val Ile Ser Glu Asp Ala Leu Val Gly Asp
Ser Val 3345 3350 3355 3360 Ile Leu Leu Ile Ala Glu Asp Val Asp Ser
Gln Pro Asn Gly Gln Ile 3365 3370 3375 His Phe Ser Ile Val Asn Gly
Asp Arg Asp Asn Glu Phe Thr Val Asp 3380 3385 3390 Pro Val Leu Gly
Leu Val Lys Val Lys Lys Lys Leu Asp Arg Glu Arg 3395 3400 3405 Val
Ser Gly Tyr Ser Leu Leu Val Gln Ala Val Asp Ser Gly Ile Pro 3410
3415 3420 Ala Met Ser Ser Thr Ala Thr Val Asn Ile Asp Ile Ser Asp
Val Asn 3425 3430 3435 3440 Asp Asn Ser Pro Val Phe Thr Pro Ala Asn
Tyr Thr Ala Val Ile Gln 3445 3450 3455 Glu Asn Lys Pro Val Gly Thr
Ser Ile Leu Gln Leu Val Val Thr Asp 3460 3465 3470 Arg Asp Ser Phe
His Asn Gly Pro Pro Phe Ser Phe Ser Ile Leu Ser 3475 3480 3485 Gly
Asn Glu Glu Glu Glu Phe Val Leu Asp Pro His Gly Ile Leu Arg 3490
3495 3500 Ser Ala Val Val Phe Gln His Thr Glu Ser Leu Glu Tyr Val
Leu Cys 3505 3510 3515 3520 Val Gln Ala Lys Asp Ser Gly Lys Pro Gln
Gln Val Ser His Thr Tyr 3525 3530 3535 Ile Arg Val Arg Val Ile Glu
Glu Ser Thr His Lys Pro Thr Ala Ile 3540 3545 3550 Pro Leu Glu Ile
Phe Ile Val Thr Met Glu Asp Asp Phe Pro Gly Gly 3555 3560 3565 Val
Ile Gly Lys Ile His Ala Thr Asp Gln Asp Met Tyr Asp Val Leu 3570
3575 3580 Thr Phe Ala Leu Lys Ser Glu Gln Lys Ser Leu Phe Lys Val
Asn Ser 3585 3590 3595 3600 His Asp Gly Lys Ile Ile Ala Leu Gly Gly
Leu Asp Ser Gly Lys Tyr 3605 3610 3615 Val Leu Asn Val Ser Val Ser
Asp Gly Arg Phe Gln Val Pro Ile Asp 3620 3625 3630 Val Val Val His
Val Glu Gln Leu Val His Glu Met Leu Gln Asn Thr 3635 3640 3645 Val
Thr Ile Arg Phe Glu Asn Val Ser Pro Glu Asp Phe Val Gly Leu 3650
3655 3660 His Met His Gly Phe Arg Arg Thr Leu Arg Asn Ala Val Leu
Thr Gln 3665 3670 3675 3680 Lys Gln Asp Ser Leu Arg Ile Ile Ser Ile
Gln Pro Val Ala Gly Thr 3685 3690 3695 Asn Gln Leu Asp Met Leu Phe
Ala Val Glu Met His Ser Ser Glu Phe 3700 3705 3710 Tyr Lys Pro Ala
Tyr Leu Ile Gln Lys Leu Ser Asn Ala Arg Arg His 3715 3720 3725 Leu
Glu Asn Ile Met Arg Ile Ser Ala Ile Leu Glu Lys Asn Cys Ser 3730
3735 3740 Gly Leu Asp Cys Gln Glu Gln His Cys Glu Gln Gly Leu Ser
Leu Asp 3745 3750 3755 3760 Ser His Ala Leu Met Thr Tyr Ser Thr Ala
Arg Ile Ser Phe Val Cys 3765 3770 3775 Pro Arg Phe Tyr Arg Asn Val
Arg Cys Thr Cys Asn Gly Gly Leu Cys 3780 3785 3790 Pro Gly Ser Asn
Asp Pro Cys Val Glu Lys Pro Cys Pro Gly Asp Met 3795 3800 3805 Gln
Cys Val Gly Tyr Glu Ala Ser Arg Arg Pro Phe Leu Cys Gln Cys 3810
3815 3820 Pro Pro Gly Lys Leu Gly Glu Cys Ser Gly His Thr Ser Leu
Ser Phe 3825 3830 3835 3840 Ala Gly Asn Ser Tyr Ile Lys Tyr Arg Leu
Ser Glu Asn Ser Lys Glu 3845 3850 3855 Glu Asp Phe Lys Leu Ala Leu
Arg Leu Arg Thr Leu Gln Ser Asn Gly 3860 3865 3870 Ile Ile Met Tyr
Thr Arg Ala Asn Pro Cys Ile Ile Leu Lys Ile Val 3875 3880 3885 Asp
Gly Lys Leu Trp Phe Gln Leu Asp Cys Gly Ser Gly Pro Gly Ile 3890
3895 3900 Leu Gly Ile Ser Gly Arg Ala Val Asn Asp Gly Ser Trp His
Ser Val 3905 3910 3915 3920 Phe Leu Glu Leu Asn Arg Asn Phe Thr Ser
Leu Ser Leu Asp Asp Ser 3925 3930 3935 Tyr Val Glu Arg Arg Arg Ala
Pro Leu Tyr Phe Gln Thr Leu Ser Thr 3940 3945 3950 Glu Ser Ser Ile
Tyr Phe Gly Ala Leu Val Gln Ala Asp Asn Ile Arg 3955 3960 3965 Ser
Leu Thr Asp Thr Arg Val Thr Gln Val Leu Ser Gly Phe Gln Gly 3970
3975 3980 Cys Leu Asp Ser Val Ile Leu Asn Asn Asn Glu Leu Pro Leu
Gln Asn 3985 3990 3995 4000 Lys Arg Ser Ser Phe Ala Glu Val Val Gly
Leu Thr Glu Leu Lys Leu 4005 4010 4015 Gly Cys Val Leu Tyr Pro Asp
Ala Cys Lys Arg Ser Pro Cys Gln His 4020 4025 4030 Gly Gly Ser Cys
Thr Gly Leu Pro Ser Gly Gly Tyr Gln Cys Thr Cys 4035 4040 4045 Leu
Ser Gln Phe Thr Gly Arg Asn Cys Glu Ser Glu Ile Thr Ala Cys 4050
4055 4060 Phe Pro Asn Pro Cys Arg Asn Gly Gly Ser Cys Asp Pro Ile
Gly Asn 4065 4070 4075 4080 Thr Phe Ile Cys Asn Cys Lys Ala Gly Leu
Thr Gly Val Thr Cys Glu 4085 4090 4095 Glu Asp Ile Asn Glu Cys Glu
Arg Glu Glu Cys Glu Asn Gly Gly Ser 4100 4105 4110 Cys Val Asn Val
Phe Gly Ser Phe Leu Cys Asn Cys Thr Pro Gly Tyr 4115 4120 4125 Val
Gly Gln Tyr Cys Gly Arg Pro Val Val Val Pro Asn Ile Gln Ala 4130
4135 4140 Gly His Ser Tyr Val Gly Lys Glu Glu Leu Ile Gly Ile Ala
Val Val 4145 4150 4155 4160 Leu Phe Val Ile Phe Ile Leu Val Val Leu
Phe Ile Val Phe Arg Lys 4165 4170 4175 Lys Val Phe Arg Lys Asn Tyr
Ser Arg Asn Asn Ile Thr Leu Val Gln 4180 4185 4190 Asp Pro Ala Thr
Ala Ala Leu Leu Asn Lys Ser Asn Gly Ile Pro Phe 4195 4200 4205 Arg
Asn Leu Arg Gly Ser Gly Asp Gly Arg Asn Val Tyr Gln Glu Val 4210
4215 4220 Gly Pro Pro Gln Val Pro Val Arg Pro Met Ala Tyr Thr Pro
Cys Phe 4225 4230 4235 4240 Gln Ser Asp Ser Arg Ser Asn Leu Asp Lys
Ile Val Asp Gly Leu Gly 4245 4250 4255 Gly Glu His Gln Glu Met Thr
Thr Phe His Pro Glu Ser Pro Arg Ile 4260 4265 4270 Leu Thr Ala Arg
Arg Gly Val Val Val Cys Ser Val Ala Pro Asn Leu 4275 4280 4285 Pro
Ala Val Ser Pro Cys Arg Ser Asp Cys Asp Ser Ile Arg Lys Asn 4290
4295 4300 Gly Trp Asp Ala Gly Thr Glu Asn Lys Gly Val Asp Asp Pro
Gly Glu 4305 4310 4315 4320 Val Thr Cys Phe Ala Gly Ser Asn Lys Gly
Ser Asn Ser Glu Val Gln 4325 4330 4335 Ser Leu Ser Ser Phe Gln Ser
Asp Ser Gly Asp Asp Asn Ala Ser Ile 4340 4345 4350 Val Thr Val Ile
Gln Leu Val Asn Asn Val Val Asp Thr Ile Glu Asn 4355 4360 4365 Glu
Val Ser Val Met Asp Gln Gly Gln Asn Tyr Asn Arg Ala Tyr His 4370
4375 4380 Trp Asp Thr Ser Asp Trp Met Pro Gly Ala Arg Leu Ser Asp
Ile Glu 4385 4390 4395 4400 Glu Val Pro Asn Tyr Glu Asn Gln Asp Gly
Gly Ser Ala His Gln Gly 4405 4410 4415 Ser Thr Arg Glu Leu Glu Ser
Asp Tyr Tyr Leu Gly Gly Tyr Asp Ile 4420 4425 4430 Asp Ser Glu Tyr
Pro Pro Pro His Glu Glu Glu Phe Leu Ser Gln Asp 4435 4440 4445 Gln
Leu Pro Pro Pro Leu Pro Glu Asp Phe Pro Asp Gln Tyr Glu Ala 4450
4455 4460 Leu Pro Pro Ser Gln Pro Val Ser Leu Ala Ser Thr Leu Ser
Pro Asp 4465 4470 4475 4480 Cys Arg Arg Arg Pro Gln Phe His Pro Ser
Gln Tyr Leu Pro Pro His 4485 4490 4495 Pro Phe Pro Asn Glu Thr Asp
Leu Val Gly Pro Pro Ala Ser Cys Glu 4500 4505 4510 Phe Ser Thr Phe
Ala Val Ser Met Asn Gln Gly Thr Glu Pro Thr Gly 4515 4520 4525 Pro
Ala Asp Ser Val Ser Leu Ser Leu His Asn Ser Arg Gly Thr Ser 4530
4535 4540 Ser Ser Asp Val Ser Ala Asn Cys Gly Phe Asp Asp Ser Glu
Val Ala 4545 4550 4555 4560 Met Ser Asp Tyr Glu Ser Val Gly Glu Leu
Ser Leu Ala Ser Leu His 4565 4570 4575 Ile Pro Phe Val Glu Thr Gln
His Gln Thr Gln Val 4580 4585
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