U.S. patent application number 10/665073 was filed with the patent office on 2005-03-24 for flexible heat exchangers for medical cooling and warming applications.
This patent application is currently assigned to Coolhead Technologies, Inc.. Invention is credited to Chen, Yunquan, Fletcher, R. David.
Application Number | 20050065581 10/665073 |
Document ID | / |
Family ID | 34312841 |
Filed Date | 2005-03-24 |
United States Patent
Application |
20050065581 |
Kind Code |
A1 |
Fletcher, R. David ; et
al. |
March 24, 2005 |
Flexible heat exchangers for medical cooling and warming
applications
Abstract
A flexible heat exchanger is suitable for heating or cooling
living subjects. The heat exchanger has a a volume having at least
one inlet for receiving a heat exchange fluid and at least one
outlet. A flexible heat exchange plate that isessentially
impermeable to the heat exchange fluid is penetrated by
substantially rigid thermally conductive members. The members
provide paths of high thermal conductivity through the plate. The
heat exchange fluid may be water.
Inventors: |
Fletcher, R. David; (White
Rock, CA) ; Chen, Yunquan; (Delta, CA) |
Correspondence
Address: |
OYEN, WIGGS, GREEN & MUTALA
480 - THE STATION
601 WEST CORDOVA STREET
VANCOUVER
BC
V6B 1G1
CA
|
Assignee: |
Coolhead Technologies, Inc.
White Rock
CA
|
Family ID: |
34312841 |
Appl. No.: |
10/665073 |
Filed: |
September 22, 2003 |
Current U.S.
Class: |
607/104 ;
607/105 |
Current CPC
Class: |
A61F 2007/0001 20130101;
F28D 2021/0077 20130101; A61F 7/02 20130101; F28F 3/12 20130101;
F28F 3/022 20130101; F28F 2255/02 20130101; A61F 2007/0054
20130101 |
Class at
Publication: |
607/104 ;
607/105 |
International
Class: |
A61F 007/00 |
Claims
What is claimed is:
1. A flexible heat exchanger for warming or cooling a living
subject, the heat exchanger comprising: a volume having at least
one inlet for receiving a heat exchange fluid and at least one
outlet; and, a flexible heat exchange plate essentially impermeable
to the heat exchange fluid, the plate comprising a plurality of
substantially rigid thermally conductive members extending through
a flexible material of the plate from an outside surface of the
plate into the volume.
2. A flexible heat exchanger according to claim 1 wherein the
volume is defined between the plate and a flexible back wall spaced
apart from the plate.
3. A flexible heat exchanger according to claim 1 wherein the
thermally conductive members are arranged in a rectangular
array.
4. A flexible heat exchanger according to claim 3 wherein the
thermally conductive members each comprise a generally rectangular
base on the outside surface of the plate.
5. A flexible heat exchanger according to claim 1 wherein the
thermally conductive members are arranged in a triangular
array.
6. A flexible heat exchanger according to claim 1 wherein the
thermally conductive members are arranged to provide a plurality of
substantially unbroken lines of the flexible material extending
between the thermally conductive members.
7. A flexible heat exchanger according to claim 1 wherein the
thermally conductive members each have a thermal conductivity of at
least 50 W.sup.-1K.sup.-1.
8. A flexible heat exchanger according to claim 1 wherein the
thermally conductive members each have a thermal conductivity of at
least 100 Wm.sup.-1K.sup.-1.
9. A flexible heat exchanger according to claim 8 wherein the
thermally conductive members are made of a material selected from
the group consisting of: aluminum, copper, gold, silver, alloys of
two or more of aluminum, copper, gold, or silver with one another
and alloys of one or more of aluminum, copper, gold, or silver with
one or more other metals.
10. A flexible heat exchanger according to claim 8 wherein the
thermally conductive members are made of materials selected from
the group consisting of: carbon, graphite, diamond, and
sapphire.
11. A flexible heat exchanger according to claim 1 wherein a
plurality of the thermally conductive members covers at least 70%
of an area of the outer side of the flexible heat exchange
plate.
12. A flexible heat exchanger according to claim 1 wherein the
flexible material of the plate comprises an elastomer material and
the thermally conductive members are embedded in the elastomer
material.
13. A flexible heat exchanger according to claim 12 wherein the
elastomer material comprises a material selected from the group
consisting of: polyurethane, polypropylene, polyethylene,
ethylene-vinyl acetate, polyvinyl chloride, silicone, natural
rubber, and a combination of two or more of polyurethane,
polypropylene, polyethylene, ethylene-vinyl acetate, polyvinyl
chloride, and silicone.
14. A flexible heat exchanger according to claim 1 wherein the
thermally conductive members project into the volume.
15. A flexible heat exchanger according to claim 14 wherein the
thermally conductive members project into the volume from the inner
surface of the plate by distances of at least 3 mm.
16. A flexible heat exchanger according to claim 1 wherein the
flexible material of the plate has a thermal conductivity not
exceeding 5 Wm.sup.-1K.sup.-1.
17. A flexible heat exchanger according to claim 1 wherein a
plurality of the thermally conductive members each comprise an
outer end comprising a base on the outer side of the plate and an
inner end projecting into the volume.
18. A flexible heat exchanger according to claim 17 wherein the
inner end of each of the plurality of thermally conductive members
comprises a plurality of spaced apart projections.
19. A flexible heat exchanger according to claim 17 wherein a
plurality of the thermally conductive members each comprise a first
part connected to the second part wherein the first and second
parts define a circumferentially extending groove and the flexible
material of the plate is received in the groove.
20. A flexible heat exchanger according to claim 17 wherein the
inner end of each of the thermally conductive members is tubular,
square, rectangular, circular or spherical.
21. A flexible heat exchanger according to claim 1 wherein the
outer surface has a concave curved configuration in the absence of
bending forces acting on the heat exchanger.
22. A flexible heat exchanger according to claim 1 wherein the
outer surface has a convex curved configuration in the absence of
bending forces acting on the heat exchanger.
23. A flexible heat exchanger according to claim 1 wherein a
portion of the outer surface of the heat exchanger on which the
thermally conductive members are disposed is dimensioned to be
applied exclusively to an area of a subject's anatomy overlying a
carotid artery of the subject.
24. A flexible heat exchanger according to claim 1 wherein a total
area of the thermally conductive members exposed on the outside
surface of the plate exceeds a total cross sectional area of the
thermally conductive members at a point where the cross sectional
members enter the volume.
25. A flexible heat exchanger according to claim 1 wherein the
volume is defined between a flexible rear wall and the flexible
plate and the heat exchanger comprises spacing means for preventing
the rear wall from collapsing against the flexible plate.
26. A flexible heat exchanger according to claim 1 wherein the
volume is defined between the flexible plate, a flexible rear wall
made of the flexible material and flexible side walls made of the
flexible material.
27. A system for controlling a temperature of a subject, the system
comprising: a heat exchanger according to claim 1; a reservoir
containing a heat exchange fluid; a first feed pump connected to
feed heat exchange fluid from the reservoir into the input of the
heat exchanger; a second feed pump connected to withdraw the heat
exchange fluid from the output of the heat exchanger.
28. A system according to claim 27 comprising a controller
connected to control operation of the first and second feed pumps
to maintain a pressure of the heat exchange fluid within the volume
within a desired range of an ambient air pressure outside the
volume.
29. A system according to claim 28 comprising an adjustable bypass
valve connected in parallel with one of the first and second feed
pumps wherein the controller is configured to operate an actuator
to adjust the bypass valve.
30. A system according to claim 27 comprising an adjustable bypass
valve connected in parallel with one of the first and second feed
pumps.
31. A system according to claim 30 wherein the adjustable bypass
valve is configured to be opened by a pressure differential across
the bypass valve.
32. A system according to claim 27 comprising a variable
restriction connected between the heat exchanger and one of the
feed pumps.
Description
TECHNICAL FIELD
[0001] The invention relates to heat exchangers. The invention has
particular application in warming or cooling living subjects. The
invention may be applied to cooling the brains or other body parts
of living subjects.
BACKGROUND
[0002] It has been discovered that quickly inducing hypothermia can
significantly improve the recovery prospects of patients who suffer
global ischemic brain injury secondary to cardiac arrest and
probably focal ischemic brain injury from thrombotic or embolic
causes. The latter is referred to as an ischemic stroke. Some
trials have placed global and focal ischemic brain damaged victims
in whole-body cooling chambers or devices. Intra vascular devices
are used for whole body cooling and, secondarily, brain cooling.
Such chambers or devices are unwieldy and can be intimidating for
the patient. Fletcher, U.S. Pat. No. 6,511,502 discloses methods
for cooling a subject's brain by applying heat exchangers to the
neck of the subject adjacent the subject's carotid arteries. The
heat exchangers cool blood flowing to the subject's brain.
[0003] In various other areas of medicine it is desirable to cool
body parts. Prior U.S. patents which relate to cooling body parts
include: U.S. Pat. Nos. 5,916,242; 4,566,455; 4,750,493; 4,763,866;
4,020,963; 5,190,032; 5,486,204; 5,643,336; 5,897,581; 5,913,855;
5,057,964; and 6,030,412.
[0004] Various types of heat exchanger exist. Air cooled heat sinks
are structures which take heat from an object and dissipate the
heat into ambient air. Such heat sinks typically consist of a
finned piece of thermally conductive material having a face which
can be placed in thermal contact with an object, such as an
electronic component, to be cooled. Some heat sinks are equipped
with fans located to flow air past the fins to improve the rate at
which heat is dissipated.
[0005] U.S. Pat. No. 6,549,411 B1 discloses a flexible heat sink
that can be attached to a generally flat surface of an object. The
heat sink can flex to conform to the surface of the object to
achieve improved contact with the object, and hence increase the
efficiency of heat transfer between the heat sink and the object.
U.S. Pat. No. 6,367,541 B2 discloses a heat sink that can be
attached to multiple electronic chips which have different heights.
The heat sink dissipates heat from the chips into ambient air. The
devices disclosed in these patents are not suitable for heating or
cooling living subjects.
[0006] U.S. Pat. No. 5,368,093 discloses a flexible bag filled with
thermal transfer fluid useful for thawing frozen foods. U.S. Pat.
No. 4,910,978 discloses a flexible pack containing a gel. The pack
can be cooled and applied to a patient for cold therapy. The pack
conforms to surface contours of the patient's body. These devices
have limited cooling capacities.
[0007] More sophisticated heat exchangers use a heat exchange fluid
such as a cooling or heating liquid instead of ambient air to carry
heat away from or provide heat to an object to be cooled or heated.
U.S. Pat. No. 5,757,615 discloses a flexible heat exchanger with
circulating water as coolant for cooling a notebook computer. U.S.
Pat. No. 5,643,336 discloses a flexible heating or cooling pad with
circulating fluid for therapeutically treating the orbital,
frontal, nasal and peri-oral regions of a patient's head. U.S. Pat.
No. 6,551,347 B1 discloses a flexible heat exchange structure
having fluid-conducting channels formed between two layers of
flexible material for heat/cold and pressure therapy. U.S. Pat.
Nos. 6,197,045 B1 and 6,375,674 B1 disclose a flexible medical pad
with an adhesive surface for adhering the pad to the skin of a
patient. U.S. Pat. No. 6,030,412 discloses a flexible enveloping
member for enveloping a head, neck, and upper back of a mammal for
cooling the brain of the mammal suffering a brain injury. All of
these heat exchangers require heat to pass through a layer of some
flexible material such as rubber, or a flexible plastic such as
polyurethane. In addition, heat is exchanged between the surface of
the flexible material and circulating fluid. Water is the most
commonly used circulating fluid.
[0008] U.S. Pat. No. 3,825,063 discloses a heat exchanger having
metal screens of fine mesh with internal plastic barriers that at
least partly penetrate the screens. The screens are stacked to
provide transverse heat conduction relative to longitudinal flow
paths. U.S. Pat. No. 4,403,653 discloses a heat transfer panel
comprising a woven wire mesh core embedded in a layer of plastic
material. The mesh and closure layer extend in the same
longitudinal direction. U.S. Pat. No. 5,660,917 discloses a sheet
with electrically insulating thermal conductors embedded in it. The
apparatus disclosed in those patents is not adapted for warming or
cooling living subjects.
[0009] Rubber and flexible plastics are poor conductors of heat
exchangers. To provide a high heat transfer efficiency in a
flexible heat exchanger in which heat is transferred across a layer
of rubber or plastic the layer must be very thin. This makes such
heat exchangers prone to damage. In addition, water is a poor heat
conductor. Heat exchange between the flexible material and water is
largely dependent on convection. Water flowing over a relatively
flat surface will not result in efficient heat exchange.
[0010] There remains a need for heat exchangers suitable for
warming or cooling a living subject(s) via the subject's skin
surface. There is a particular need for such heat exchangers that
have high ratio of heat-transfer capacity to skin contact area.
There is also a need for heat exchangers which can be used in
practicing the methods described in Fletcher, U.S. Pat. No.
6,511,502 and which avoid at least some disadvantages of prior heat
exchangers.
SUMMARY OF THE INVENTION
[0011] The invention relates to heat exchangers. One aspect of the
invention provides a flexible heat exchanger. The heat exchanger
comprises a volume having at least one inlet for receiving a heat
exchange fluid and at least one outlet. A heat exchange fluid, for
example, water, can flow through the volume. A flexible heat
exchange plate essentially impermeable to the heat exchange fluid
has a plurality of substantially rigid thermally conductive
members. The thermally conductive members extend through a flexible
material of the plate from an outside surface of the plate into the
volume. The thermally conductive members conduct heat between a
subject and the heat exchange fluid.
[0012] In some embodiments the volume is defined between the plate
and a flexible back wail spaced apart from the plate. The thermally
conductive elements are arranged in an arrangement which permits
the plate to flex to conform to surface contours of the
subject.
[0013] In preferred embodiments the thermally conductive members
each have a thermal conductivity of at least 50 Wm.sup.-1 K.sup.-1
and preferably at least 100 Wm.sup.-1 K.sup.-1. The thermally
conductive elements may be made of materials such as aluminum,
copper, gold, silver, alloys of two or more of aluminum, copper,
gold, or silver with one another, alloys of one or more of
aluminum, copper, gold, or silver with one or more other metals,
carbon, graphite, diamond, or sapphire.
[0014] The thermally conductive members may cover a substantial
portion of the outer surface of the flexible heat exchange plate.
For example, the thermally conductive members may be exposed in an
area of at least 50%, preferably at least 70% and, in some
embodiments, at least 80% of an area of the flexible heat exchange
plate.
[0015] The flexible material of the plate may comprise an elastomer
material. The thermally conductive members may be embedded in the
elastomer material by any suitable process. The elastomer material
may comprise, for example, natural rubber, polyurethane,
polypropylene, polyethylene, ethylene-vinyl acetate, polyvinyl
chloride, silicone, or a combination of two or more of
polyurethane, polypropylene, polyethylene, ethylene-vinyl acetate,
polyvinyl chloride, and silicone. In some embodiments the elastomer
material has a thermal conductivity not exceeding 5 Wm.sup.-1
K.sup.-1.
[0016] Another aspect of the invention provides systems for heating
or cooling a subject. The systems have a reservoir holding heat
exchange fluid and a pair of feed pumps. One feed pump is connected
to deliver the heat exchange fluid to a heat exchanger. Another
feed pump is connected to withdraw the heat exchange fluid from the
heat exchanger. The rate at which the heat exchange fluid is
introduced into the heat exchanger by the first fed pump is
balanced with the rate at which fluid is withdrawn from the heat
exchanger by the second feed pump to maintain a pressure within a
volume in the heat exchanger within a desired range of an ambient
pressure.
[0017] Further aspects of the invention and features of specific
embodiments of the invention are described below.
BRIEF DESCRIPTION OF THE DRAWINGS
[0018] In drawings which illustrate non-limiting embodiments of the
invention:
[0019] FIGS. 1A, 1B and 1C are respectively a longitudinal
elevational cross-section view; a top plan view and a bottom plan
view of a flexible heat exchanger configured as a cooling/warming
pad for a subject's neck
[0020] FIGS. 2A, 2B and 2C are respectively a cross-section view; a
bottom view; and a top view of the flexible heat exchange plate of
a heat exchanger according to an alternative embodiment of the
invention;
[0021] FIG. 2D is a partial view of the outside surface of a heat
exchanger having thermally conductive members arranged in a
triangular array;
[0022] FIG. 2E is a partial view of the outside surface of a heat
exchanger having thermally conductive members arranged to provide
converging lines of flexible material;
[0023] FIG. 2F is a view of the outside surface of a heat exchanger
having thermally conductive members arranged in a rectangular array
oriented at an angle to a long axis of the heat exchanger;
[0024] FIGS. 3A, 3B and 3C are respectively a cross-section view; a
bottom view; and a top view of the flexible heat exchange plate of
a heat exchanger according to one embodiment of the invention;
[0025] FIGS. 4A through 4L are views of different heat conductors
that can be used in heat exchangers according to different
embodiments of the invention;
[0026] FIGS. 5A and 5B are respectively sectional and bottom views
of a flexible plate of a heat exchanger according to another
embodiment of the invention; and
[0027] FIGS. 6, 7 and 8 are schematic views of cooling systems
according to the invention.
DESCRIPTION
[0028] Throughout the following description, specific details are
set forth in order to provide a more thorough understanding of the
invention. However, the invention may be practiced without these
particulars. In other instances, well known elements have not been
shown or described in detail to avoid unnecessarily obscuring the
invention. Accordingly, the specification and drawings are to be
regarded in an illustrative, rather than a restrictive, sense.
[0029] Some embodiments of this invention provide flexible heat
exchangers suitable for use in warming or cooling living subjects.
Heat exchangers according to the invention have a flexible heat
exchange plate. A plurality of thermal channels pass through the
flexible heat exchange plate. The flexible heat exchange plate has
a plurality of thermally conductive members projecting through a
flexible fluid essentially impermeable medium that is essentially
fluid-impermeable. The thermally conductive members provide
higher-temperature effective means to accept heat from a
higher-temperature side, channel the heat through the medium, and
release the heat on a lower-temperature side of the flexible heat
exchange plate.
[0030] An outer side of the flexible heat exchange plate can be
brought into contact with a living subject. In preferred
embodiments, an inner side of the flexible heat exchange plate
forms one side of a channel which carries a heat exchange
fluid.
[0031] The thermally conductive members may be made of any suitable
thermally conductive materials including thermally conductive
metals, for example, aluminum, copper, gold, silver, or alloys of
these metals with one another and with other metals. The thermally
conductive members may also be made of non-metals which have high
thermal conductivities such as carbon, suitable grades of graphite,
diamond, sapphire or the like. Preferably the thermally conductive
members are made from materials having thermal conductivities, k,
of at least 50 Wm.sup.-1K.sup.-1 and preferably at least 100
Wm.sup.-1K.sup.-1.
[0032] The thermally conductive members are sized and located to
permit the thermally conductive plate to be flexed sufficiently to
conform substantially to a part of a body of a living subject. The
thermally conductive members are dimensioned and distributed in a
manner so that the thermally conductive members cover a large
proportion of the area of the outer side of the flexible heat
exchange plate. In certain embodiments of the invention a plurality
of the thermally conductive members cover at least 50%, preferably
at least 70%, and most preferably at least 80% of an area of the
outer side of the flexible heat exchange plate.
[0033] In some embodiments of the invention a plurality of the
thermally conductive members have thermally conductive pins, fins,
bars or the like that project into the volume of a heat exchanger
to form an efficient heat exchange interface with heat exchange
fluid in the volume. The projecting pins, fins, bars, plates or the
like that form a heat exchange interface with the fluid inside the
volume of a heat exchanger may or may not be similar in shape or
other physical characteristics to the pins, fins, bars, plates or
the like that extend through the flexible medium to form a thermal
channel through the medium.
[0034] The following example embodiments of the invention will be
described in the context of cooling a living subject. Embodiments
of the invention could also be applied to warming a subject.
[0035] FIGS. 1A through 1C show a heat exchanger 10 according to an
embodiment of the invention. Heat exchanger 10 has a flexible heat
exchange plate 12 penetrated by a number of thermally conductive
members 14. Plate 12 has an outer face 16 and an inner face 18.
Heat exchanger 10 has an inside volume 20 and ports 22, 23 by way
of which a heat exchange fluid can flow through volume 20. Volume
20 is defined on a front side by plate 12 and on a rear side by a
rear wall 24. Side walls 25 extend between plate 12 and rear wall
24. Plate 12, rear wall 24 and side walls 25 are all flexible so
that the outer surface 16 of heat exchanger 10 can conform to the
local contours of a portion of a subject's anatomy.
[0036] Thermally conductive members 14 pass through the material 30
of plate 12. Inside ends 26 of thermally conductive members 14
project into volume 20. Ends 26 preferably project significantly
into volume 20. In the illustrated embodiment, ends 26 are cut away
to provide increased surface area for heat transfer with fluid in
volume 20. Each inner end 26 comprises a number of prongs 27. Outer
faces 28 of thermally conductive members can be placed against the
skin of a subject. Outer faces 28 may be outer faces of bases 29.
Bases 29 are separated sufficiently to permit heat exchanger 10 to
flex in a desired degree but are preferably closely spaced to
maximize the area of outer faces 28 that can be placed against a
desired region on a subject. For example, in some embodiments,
bases 29 are spaced apart from one another by spacings in the range
of 0.5 mm to 5.0 mm.
[0037] In some embodiments, each base 29 has a thickness in the
range of 0.5 mm to 5 mm. Preferably, base 29 has a thickness in the
range of 1 mm to 2.5 mm. The size and dimensions of base 29 in the
plane of plate 12 may be chosen to suit the application, and
particularly depends on the contour of the object to be cooled or
heated. Thermally conductive members 14 according to some
embodiments of the invention for use in cooling/warming pads for
human subjects, have bases 29 having areas in the range of 1
mm.sup.2 to 400 mm.sup.2. For such cooling/heating pads the area is
preferably in the range of 10 mm.sup.2 to 100 mm.sup.2.
[0038] Thermally conductive members 14 may have reduced cross
sectional areas in their portions inside bases 29. The
cross-sectional area of thermally conductive members 14 at the
point that thermally conductive members 14 emerge from material 30
on the inside face of plate 12 may, for example, be in the range of
20% to 100%, and preferably 35% to 65%, of the area of base 29.
[0039] Plate 12 comprises a flexible membrane through which
thermally conductive members 14 project. The membrane may be made
of a flexible material or materials 30. Thermally conductive
members have lengths sufficient to pass through material 30. In
preferred embodiments, members 14 project into volume 20. Thermally
conductive members 14 may, for example, project into volume 20 for
a distance in the range of 0 mm to 20 mm. In some embodiments
intended for warming or cooling a living subject, thermally
conductive members 14 project into volume 20 for a distance in the
range of 2 mm to 10 mm. In some embodiments members 14 project past
material 30 by at least 3 mm. The portions of members 14 which
project into volume 20 may also function as supports to maintain a
minimum spacing between wall 24 and plate 12.
[0040] It is not necessary that all thermally conductive members 14
be identical or that all thermally conductive members 14 have
equal-sized bases 29 although it is convenient to make heat
exchanger 10 with thermally conductive members 14 substantially the
same as one another.
[0041] In some embodiments, rear wall 24 is made of material 30.
Substantially all of heat exchanger 10, except for thermally
conductive members 14, may be made of the same material or
materials 30. Material 30 is preferably both flexible and
elastically stretchable. Material 30 may, for example, comprise any
of a variety of suitable flexible polymers such as natural rubber,
polyurethane, polypropylene, polyethylene, ethylene-vinyl acetate,
polyvinyl chloride, silicone, a combination of these materials or
the like. Material 30, or portions of material 30 may optionally be
loaded with particles of one or more thermally conductive materials
such as metal or graphite. However, since material 30 is not
required to play a significant role in conducting heat, material 30
may be a material having a low thermal conductivity not exceeding 5
Wm.sup.-1K.sup.-1 without significantly impairing the function of
heat exchanger 10. In some embodiments, material 30 has a hardness
in the range of 10 to 80 on the Shore A hardness scale.
[0042] One specific example embodiment of the invention is
constructed as shown in FIGS. 1A to 1C and is designed to be
applied to the neck of a human subject to cool the subject's brain.
This embodiment of heat exchanger 10 has approximately 50 thermally
conductive members 14 arranged in a rectangular array. Each member
14 has nine pins which project into volume 20. Bases 29 have areas
of about 10 mm.times.10 mm and thicknesses of about 2 mm. Each of
the pins has a diameter of about 1.8 mm. The total length of each
of the pins is about 10 mm. The thickness of material 30 in the
walls of heat exchanger 10 is about 4 mm. Two short acrylic tubes
of approximately 10 mm inner diameter provide inlet and outlet
ports 22 and 23. Cold water may be used as a cooling fluid.
[0043] Two such heat exchangers may be dimensioned so that they can
be applied to a subject's neck respectively over the left and right
carotid arteries to cool the subject's brain by cooling blood
flowing to the subject's brain. The heat exchangers are
sufficiently flexible to conform substantially to the curvature of
the subject's neck without causing unacceptable pressure spots. The
heat exchangers may be held in place under a collar, such as a foam
collar.
[0044] Plate 12 may be fabricated using any suitable process. For
example, plate 12 may be made by making holes in a sheet of
material 30 and inserting thermally conductive members 14 through
the holes. The holes may initially have dimensions smaller than
corresponding dimensions of thermally conductive members 14 so that
material 30 seals around thermally conductive members 14
sufficiently to prevent any significant loss of heat exchange fluid
from volume 20. Additionally, or in the alternative, a sealant,
such as a suitable glue may be provided to enhance the seal between
thermally conductive members 14 and material 30. Plate 12 may also
be made by a suitable plastic manufacturing process such as thermal
injection molding, reaction injection molding, compression molding,
vacuum forming or casting. In this case, thermally conductive
members 14 may be molded into plate 12.
[0045] The thickness of material 30 in plate 12 can be selected to
provide a desired compromise between flexibility and durability.
Since heat exchanger 10 does not rely on material 30 to conduct
heat, it is not necessary to make material 30 extremely thin to
improve heat conduction. Material 30 may, for example, have a
thickness in the range of about 1 mm to 20 mm. In some currently
preferred embodiments of the invention, material 30 has a thickness
in the range of 4 mm to 7 mm in plate 12. When thermally conductive
members of the type shown in FIGS. 4I to FIG. 4L are used, the
thickness of material 30 may be smaller, for example, as little as
about 1 mm in plate 12.
[0046] Projections of material 30 or some other material may
optionally extend into volume 20. Such projections may be
positioned to support wall 24 relative to plate 12, to direct the
flow of fluid 65 within volume 20 and/or to induce turbulence at
selected locations in the flow of fluid 65 in order to provide
enhanced thermal contact between thermally conductive members 14
and fluid 65.
[0047] Thermally conductive members 14 may be arranged in a wide
range of patterns. For example, as shown in FIGS. 1A to 1C and 3A
to 3C, members 14 may be arranged in a number of rows and columns
to form a rectangular array, which could be a square array. In some
embodiments, members 14 are arranged in rows or columns which are
shifted relative to one another as shown in FIGS. 2B and 2C. This
arrangement creates increased turbulence in fluid flowing through
volume 20 and hence increases the efficiency of heat transfer
between the inside ends of thermally conductive members 14 and
fluid 65. In some embodiments, bases of members 14 are arranged in
a rectangular array as illustrated, for example, in FIG. 1, while
portions of members 14 which project into volume 20 are arranged in
rows or columns which are shifted relative to one another as shown
in FIGS. 2B and 2C. In some embodiments, members 14 are arranged in
a triangular array, as shown in FIG. 2D.
[0048] Flexing of plate 12 may be facilitated by arranging members
14 to provide substantially unbroken lines 31 of material 30
extending generally parallel to one or more axes about which a user
may wish to flex heat exchanger 10. The embodiment shown in FIG. 1B
shows two sets of lines 31 of material 30 which extend between
adjacent rows and columns of members 14. The embodiment illustrated
in FIG. 2B has one set of parallel lines 31. Lines 31 are not
necessarily parallel to one another. For example, FIG. 2E
illustrates an arrangement of members 14 which facilitates flexing
in such a way as to conform to a portion of the surface of a cone.
The array of members 14 is not necessarily aligned with any axis of
heat exchanger 10. For example, FIG. 2F shows the outside face of a
heat exchanger wherein thermally conductive members 14 are arranged
in a rectangular array oriented at an angle, .phi., to a long axis
of the heat exchanger.
[0049] FIGS. 1A to 1C and 2A to 2F illustrate heat exchangers in
which faces 28 are substantially flush with material 30 on outer
face 16. This arrangement facilitates cleaning, as outer face 16 is
substantially smooth. FIGS. 3A to 3C illustrate an alternative
embodiment of the invention wherein base 29 is not embedded in
material 30. The embodiments illustrated in these Figures can be
fabricated by inserting thermally conductive members 14 though
holes formed in a sheet of material 30.
[0050] Thermally conductive members 14 may take any of a wide
variety of forms which provide the function of carrying heat in
either direction between a subject on one side of the flexible
plate and a heat exchange fluid or other matter on an opposed side
as the flexible plate that is warmer or cooler than the subject.
Ideally, members 14 provide good thermal interfaces between the
thermally conductive members and the subject to be cooled or
warmed; good thermal channels across flexible material 30; and good
thermal interfaces between the thermally conductive members and the
fluid in volume 20 of the thermal exchanger. Some possible forms
for members 14 are illustrated in FIGS. 4A through 4L. It is
understood that these are possible forms and are included only as
examples. Modifications to these examples can be made to obtain a
much larger list of examples. In addition, features illustrated in
these examples can be exchanged or combined partially or fully to
obtain an even larger list of examples.
[0051] FIG. 4A shows a thermally conductive member 14A having a
square base 29 and cylindrical pin 32. Pin 32 can carry heat
through material 30 and constitute a means for channeling heat
through flexible material 30 and releasing heat into (or taking
heat from) fluid in volume 20 of a heat exchanger. FIG. 4B shows a
thermally conductive member 14B having a circular base 29 instead
of a square base.
[0052] FIG. 4C shows a thermally conductive member 14C wherein both
base 29 and the pin 32 are square in cross-section (like the
thermally conductive members of FIGS. 2A to 2C). FIG. 4D shows a
thermally conductive member 14D similar to member 14A except that
pin 32 has a circumferential groove 33 in its part close to base
29. Groove 33 receives extra material 30 in an injection molding or
casting process to better seal member 14D to material 30. FIG. 4E
shows a thermally conductive member 14E wherein a tip of pin 32 is
tapered to facilitate insertion into a hole in a sheet of material
30.
[0053] FIG. 4F shows a thermally conductive member 14F having a
pair of platelike rectangular conductors 34 which serve both as
thermal channels through material 30 and as structures for
releasing heat into (or taking heat from) volume 20. Conductors 34
may be arranged in a V-shape to better transfer heat to fluid
flowing past plates 34. Plate-like conductors could also be
arranged in other manners such as being parallel with each other.
Thermally conductive member 14F has the advantage in manufacturing
that it can be made by cutting and folding thermally conductive
sheet material.
[0054] FIG. 4G shows a thermally conductive element 14G having a
thermal channel portion provided by a tubular pin 36. FIG. 4H shows
a thermally conductive member 14H having multiple pins 38 extending
from base 29. Pins 38 provide multiple thermal channels extending
from the same base 29 and projecting into the volume 30. Conductive
member 14H advantageously provides increased contact area between
conductive member 14H and a heat transfer fluid in volume 20. FIGS.
4I and 4J show a thermally conductive member 14J that is designed
to reduce the possibility of fluid leaking between material 30 and
member 14I. Member 14I may be fabricated in two-pieces 14I-1 and
14I-2 that can be assembled together in a manner that provides good
thermal contact between pieces 14I-1 and 14I-2. In the illustrated
embodiment, one of the pieces of member 141 has a pin 39 which is
received in a corresponding socket 40 (see FIG. 3J) in the other
piece. Pin 39 may have an interference fit in socket 40 to keep the
two pieces tightly together and to provide good heat transfer
between the pieces. A circumferentially extending groove 41 is
defined between pieces 14I-1 and 14I-2. Groove 41 receives material
30. The faces of pieces 14I-1 and 14I-2 which contact material 30
may be undercut to provide ridges 42 which help to prevent fluid
from leaking past member 141. The pieces of multi-piece thermally
conductive members may be fastened together in other ways which
provide thermal contact between the pieces. For example, fastening
means such as screws, rivets, or the like may be provided. FIGS. 4K
and 4L show a thermally conductive member 14K that is similar to
member 14I but is an integral part. Member 14K is designed to be
cramped onto material 30. Material 30 projects into a groove 43.
The sides of the groove 43 may be cramped together to hold material
30 around the edges of member 14K as shown in FIG. 4L.
[0055] FIGS. 5A and 5B show a flexible fluid heat exchanger 50
which is normally curved in the absence of applied forces. Heat
exchanger 50 may be used to apply heat to or to cool a
substantially cylindrical object such as a subject's limb. Apart
from being curved, heat exchanger 50 is similar to heat exchanger
10 of FIGS. 1A through 1C.
[0056] A suitable circulation system may be used to circulate a
heat exchange fluid through the volume 20 of one or more heat
exchangers as described herein. For cooling purposes it is
desirable that the temperature of circulating fluid 65 be greater
than 0.degree. C. to avoid freezing the subject's skin. The desired
temperature of the circulating fluid will depend to some degree on
the application and the portion of the subject's body to be
treated. The desired temperature for cold therapy ranges between
0.degree. C. and 15.degree. C. Water has properties which make it
good for use as a circulating fluid 65.
[0057] It is generally desirable to maintain the pressure of fluid
in volume 20 approximately equal to the air pressure surrounding
heat exchanger 10. If the pressure within volume 20 is
significantly smaller than the ambient air pressure then pressure
differences across the walls of volume 20 will tend to collapse
volume 20 although the projected ends 26 of thermally conductive
members 14 may prevent the walls from complete collapse. If the
pressure within volume 20 is significantly larger than the ambient
air pressure then heat exchanger 10 will tend to balloon.
[0058] FIG. 6 is a schematic view of a cooling system which
includes a heat exchanger 10 and a fluid circulating system 60.
Circulation system 60 has an insulated reservoir 62 containing a
volume of ice 64. System 60 contains a suitable heat exchange fluid
65, which may be liquid water. System 60 delivers fluid 65 to heat
exchanger 10 through delivery conduit 66 and returns coolant to
reservoir 62 through a return conduit 67.
[0059] A first feed pump 70 upstream from heat exchanger 10
delivers fluid 65 from reservoir 62 to heat exchanger 10. A second
feed pump 72 is located downstream from heat exchanger 10. Second
feed pump 72 draws fluid 65 from heat exchanger 10 and returns the
fluid to reservoir 62. First and second feed pumps 70 and 72 are
balanced so that within volume 20 of heat exchanger 10 the pressure
of fluid 65 is substantially equal to the ambient air pressure.
[0060] One or more bypass valves may be provided to provide better
control over fluid pressure within volume 20. In system 60, an
adjustable bypass valve 74 is connected between the output of first
feed pump 70 and reservoir 62. Bypass valve 74 indirectly regulates
the pressure within volume 20. When bypass valve 74 is opened, a
larger proportion of fluid 65 is returned to reservoir 62 by way of
bypass conduit 75 and the amount of fluid 65 flowing into heat
exchanger 10 is reduced. Bypass valve 74 may be
pressure-operated.
[0061] System 60 has a second bypass valve 76 connected in parallel
with second feed pump 72. When second bypass valve 76 is open,
second feed pump 72 can draw fluid 65 from reservoir 62 by way of
conduit 77. Opening second bypass valve 76 increases pressure at
the input of second feed pump 72 and consequently increases the
pressure within volume 20.
[0062] Many variations of system 60 are possible. Although two
bypass valves are shown in FIG. 6 for maximum flexibility, one
bypass valve connected parallel with either one of pumps 70 or 72
or in parallel with heat exchanger 10 may be sufficient to permit
pressure inside heat exchanger 10 to be maintained within a desired
range. In addition, depending upon the construction of pumps 70 and
72 and the fluid flow properties of the circuit which includes
conduits 66, 67 and heat exchanger 10 it may be possible to
maintain the fluid pressure in volume 20 within the desired range
without the need for bypass valves 74 and 76. Where bypass valves
are provided it is not necessary that they be connected directly to
reservoir 62 as illustrated. Other connections may be provided
which have the result of maintaining pressures upstream and/or
downstream from heat exchanger 10 at values which keep the pressure
within volume 20 at a desired level while maintaining fluid flow
through volume 20.
[0063] In some cases it may be convenient to provide a single
reservoir 62 for providing heat exchange fluid for multiple heat
exchangers 10. In such cases it is best to provide upstream and
downstream pumps 70 and 72 for each heat exchanger 10. In the
alternative, suitable manifolds, such as T-connectors, could be
provided to allow a number of heat exchangers 10 to be connected in
parallel between a single upstream pump system and a single
downstream pump system.
[0064] FIG. 7 illustrates another fluid circulating system 60A. In
system 60A, a first flow regulator 78 comprising a restrictor 80
and a bypass valve 82 is provided between first feed pump 70 and
heat exchanger 10. Bypass valve 82 is connected in parallel with
restrictor 80. When fluid 65 is flowing through flow regulator 78
then a pressure drop across flow regulator 78 depends upon the
fluid flow rate and upon the degree to which bypass valve 82 is
open.
[0065] System 60A has a second flow regulator 79 which includes a
second flow restrictor 84 and a bypass valve 86. Bypass valve 86 is
connected in parallel with restrictor 84.
[0066] In system 60A, bypass valves 82 and 86 are adjustable. The
fluid pressure within volume 20 can be controlled by adjusting one
or both of bypass valves 82 and 86.
[0067] Some alternative embodiments of the invention lack one of
flow regulators 78 and 79. When system 60A is connected to supply
fluid 65 to a plurality of heat exchangers 10 it is preferable to
provide for each heat exchanger 10 at least one adjustable flow
regulator 78 or 79 located where only fluid going to or from that
heat exchanger passes through the flow regulator. This permits the
pressure within each heat exchanger 10 to be individually
regulated. In the alternative, as described above, suitable
manifolds may be provided to split the flow of fluid 65 between a
number of heat exchangers 10 connected in parallel.
[0068] FIG. 8 illustrates another fluid circulating system 60B. In
system 60B the pressure within volume 20 of heat exchanger 10 is
controlled by adjusting the rate of operation of one or both of
upstream and downstream feed pumps 70 and 72. In some embodiments
of the invention a control system simultaneously increases the rate
of operation of feed pump 70 and decreases the rate of operation of
feed pump 72 or vice versa. The rate of operation of pumps 70 and
72 may be controlled by adjusting the rate of rotation of motors
which drive the pumps, by adjusting displacements of the pumps, or
the like.
[0069] In the illustrated embodiment, control is accomplished by
operating a power splitter 88 (illustrated schematically by a
potentiometer). Power splitter 88 can be operated to increase the
speed of a motor driving pump 70 and to decrease the speed of a
motor driving pump 72 or vice versa.
[0070] Systems 60, 60A and 60C may be automatically controlled
using any suitable control system. For example, a controller may be
provided to operate bypass valves and/or control pump speeds or
displacements by way of suitable actuators (not shown) as necessary
to control pressure within volume 20 to stay within a desired
range. Those skilled in the art are familiar with suitable
controllers. The controller may, for example, comprise a suitable
programmed programmable controller or a hardware controller. One or
more pressure sensors and/or flow sensors (not shown ) may be
included to provide feedback to the controller.
[0071] Any of cooling systems 60, 60A and 60B could be adapted for
warming by replacing ice 64 with a suitable heating element which
can be operated to raise fluid 65 in reservoir 62 to a desired
temperature. Instead of ice 64, any of systems 60, 60A or 60B could
cool fluid 65 by way of a refrigeration system. However, a
refrigeration system large enough to provide high-rate cooling of a
living person is expensive, consumes a large amount of power and is
not readily portable. Ice has the advantage that melting a block of
ice takes a large amount of heat. A reservoir 62 containing enough
ice to apply high rate cooling to a human subject for a significant
period can be small enough to be readily portable.
[0072] Where a component (e.g. a member, assembly, element, device,
circuit, etc.) is referred to above, unless otherwise indicated,
reference to that component (including a reference to a "means")
should be interpreted as including as equivalents of that component
any component which performs the function of the described
component (i.e., that is functionally equivalent), including
components which are not structurally equivalent to the disclosed
structure which performs the function in the illustrated exemplary
embodiments of the invention.
[0073] As will be apparent to those skilled in the art in the light
of the foregoing disclosure, many alterations and modifications are
possible in the practice of this invention without departing from
the spirit or scope thereof. For example:
[0074] Thermally conductive members 14 may have any suitable shapes
and arrangements. Those illustrated herein are but examples.
[0075] Flexible material 30 may have different compositions in
different parts of a heat exchanger according to the invention.
Different suitable flexible materials 30 may be used for material
30 in different parts of a heat exchanger.
[0076] A heat exchanger according to the invention is not
necessarily rectangular or parallel-sided. A heat exchanger
according to the invention could have other shapes. Heat exchangers
according to some currently preferred embodiments of the invention
are elongated and have fluid inlets and fluid outlets located in
areas at opposed ends of a long axis.
[0077] Accordingly, the scope of the invention is to be construed
in accordance with the substance defined by the following
claims.
* * * * *