U.S. patent application number 10/960575 was filed with the patent office on 2005-03-03 for inhalant medicator.
This patent application is currently assigned to UNISIA JECS CORPORATION. Invention is credited to Ishizeki, Kazunori, Nakamura, Shigemi, Ohki, Hisatomo, Yanagawa, Akira, Yazawa, Yoshiyuki.
Application Number | 20050048003 10/960575 |
Document ID | / |
Family ID | 26579598 |
Filed Date | 2005-03-03 |
United States Patent
Application |
20050048003 |
Kind Code |
A1 |
Ohki, Hisatomo ; et
al. |
March 3, 2005 |
Inhalant medicator
Abstract
A blister pack for an inhalant medicator has a plurality of
medical powder storage chambers spaced apart from each other in a
circumferential direction. The inhalant medicator includes a
pricking tool with a pair of parallel pins that prick inflow and
outflow holes in one of the medical powder storage chambers during
a preliminary operation of inhalant medication. The inflow and
outflow holes are spaced apart from each other by a predetermined
distance in a direction parallel to a lid panel of the blister pack
to produce turbulent airflow within the medical powder storage
chamber during inhalation during which the medical powder is
inhaled by a patient's breathing. The medical powder storage
chambers are dimensioned and designed to properly regulate or
control properties of the airflow passing through the medical
storage chamber, to ensure the airflow is suitable for the medical
powder stored in the storage chamber.
Inventors: |
Ohki, Hisatomo; (Gunma,
JP) ; Nakamura, Shigemi; (Gunma, JP) ;
Ishizeki, Kazunori; (Gunma, JP) ; Yazawa,
Yoshiyuki; (Gunma, JP) ; Yanagawa, Akira;
(Yokohama, JP) |
Correspondence
Address: |
FOLEY AND LARDNER
SUITE 500
3000 K STREET NW
WASHINGTON
DC
20007
US
|
Assignee: |
UNISIA JECS CORPORATION
DOTT LIMITED COMPANY
|
Family ID: |
26579598 |
Appl. No.: |
10/960575 |
Filed: |
October 8, 2004 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
|
|
10960575 |
Oct 8, 2004 |
|
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|
09703794 |
Nov 2, 2000 |
|
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|
6810872 |
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Current U.S.
Class: |
424/46 ;
128/200.23 |
Current CPC
Class: |
A61M 15/0033 20140204;
A61M 2202/064 20130101; A61M 11/002 20140204; A61M 2206/16
20130101; A61M 15/0035 20140204; A61M 15/0048 20140204; A61M
15/0045 20130101 |
Class at
Publication: |
424/046 ;
128/200.23 |
International
Class: |
A61L 009/04; A61K
009/14; A61M 011/00 |
Foreign Application Data
Date |
Code |
Application Number |
Dec 10, 1999 |
JP |
11-352280 |
Dec 10, 1999 |
JP |
11-352281 |
Claims
What is claimed is:
1. An inhalant medicator comprising: a medicator body including a
holder mounting portion at one axial end and an inhalant port at
the other axial end for inhalation of medical powder; a holder
detachably rotatably mounted to the holder mounting portion and
holding thereon a blister pack having a plurality of medical powder
storage chambers spaced apart from each other in a circumferential
direction thereof; the medicator body having a portion defining an
inflow air passage to supply atmosphere toward one of the plurality
of medical powder storage chambers of the blister pack held on the
holder which is mounted to the holder mounting portion; the
medicator body having a portion defining an outflow air passage to
flow out the medical powder stored in the one medical powder
storage chamber of the blister pack held on the holder toward the
inhalant port; and a pricking tool attached to the medicator body
to prick an inflow hole and an outflow hole in the one medical
powder storage chamber of the blister pack, so that the inflow hole
is fluidly communicated with the inflow air passageway and the
outflow hole is fluidly communicated with the outflow air
passageway.
2. The inhalant medicator as claimed in claim 1, wherein the inflow
and outflow holes are spaced apart from each other by a
predetermined distance between a downstream end of the inflow air
passageway and an upstream end of the outflow air passageway.
3. The inhalant medicator as claimed in claim 2, wherein the
medicator body comprises upper and lower medicator-body portions
and a joining portion through which the upper and lower
medicator-body portions are formed integral with each other, and
the upper and lower medicator-body portions define therebetween a
holder mounting groove which opens to three directions, and the
holder comprises a disc-shaped holder so that the disc-shaped
holder is inserted into and removed from within the holder mounting
groove.
4. The inhalant medicator as claimed in claim 3, wherein the
medicator body has a protruded portion formed on the lower
medicator-body portion which is a center of rotation of the holder,
and the holder has a plurality of recessed fit portions each of
which is formed on an upside of the holder and is fitted to one of
the plurality of medical powder storage chambers of the blister
pack, and the holder has a portion defining a guide groove which is
formed on an underside of the holder to guide the protruded portion
to the center of rotation of the holder.
5. The inhalant medicator as claimed in claim 4, which further
comprises a positioning mechanism provided between the holder
mounting portion of the medicator body and the holder, for
positioning the one medical powder storage chamber of the blister
pack held on the holder at a predetermined pricking position of the
pricking tool.
6. The inhalant medicator as claimed in claim 5, wherein the
positioning mechanism comprises a spring-loaded ball housed in a
bore formed in the medicator body and closed at one end, and a
spring operably disposed in the bore so as to bias the ball in a
direction that causes a part of a spherical surface of the ball to
be protruded through an opening end of the bore into the holder
mounting groove.
7. An inhalant medicator comprising: a medicator body including a
holder mounting portion at one axial end and an inhalant port at
the other axial end for inhalation of medical powder; a holder
detachably rotatably mounted to the holder mounting portion and
holding thereon a blister pack having a plurality of blistered
portions spaced apart from each other in a circumferential
direction thereof; the medicator body having a portion defining a
pair of inflow air passages to supply atmosphere toward one of the
plurality of blistered portions of the blister pack held on the
holder which is mounted to the holder mounting portion; the
medicator body having a portion defining a pair of outflow air
passages to flow out the medical powder stored in the one blistered
portion of the blister pack held on the holder toward the inhalant
port; a pricking tool attached to the medicator body and having a
pair of pins to prick upper and lower inflow holes and upper and
lower outflow holes in the one blistered portion of the blister
pack, so that the upper inflow hole is fluidly communicated with a
first one of the inflow air passageways, the lower inflow hole is
fluidly communicated with the second inflow air passageway, the
upper outflow hole is fluidly communicated with a first one of the
outflow air passageways, the lower outflow hole is fluidly
communicated with the second outflow air passageway; the upper
inflow and outflow holes being spaced apart from each other by a
predetermined distance between a downstream end of the first inflow
air passageway and an upstream end of the first outflow air
passageway; and the lower inflow and outflow holes being spaced
apart from each other by a predetermined distance between a
downstream end of the second inflow air passageway and an upstream
end of the second outflow air passageway.
8. The inhalant medicator as claimed in claim 7, wherein the
medicator body is substantially cylindrical in shape and comprises
upper and lower medicator-body portions and a joining portion
through which the upper and lower medicator-body portions are
formed integral with each other, and the upper and lower
medicator-body portions define therebetween a holder mounting
groove which opens to leftward and rightward directions and to one
axial direction of the medicator body, and the holder comprises a
disc-shaped holder so that the disc-shaped holder is inserted into
and removed from within the holder mounting groove.
9. The inhalant medicator as claimed in claim 8, wherein the
medicator body has a protruded portion formed on the lower
medicator-body portion which is a center of rotation of the holder,
and the holder has a plurality of recessed fit portions each of
which is formed on an upside of the holder and is fitted to one of
the plurality of blistered portions of the blister pack, and the
holder has a portion defining a guide groove which is formed on an
underside of the holder to guide the protruded portion to the
center of rotation of the holder.
10. The inhalant medicator as claimed in claim 9, which further
comprises a positioning mechanism provided between the holder
mounting portion of the medicator body and the holder, for
positioning the one blistered portion of the blister pack held on
the holder at a predetermined pricking position of the pricking
tool.
11. The inhalant medicator as claimed in claim 10, wherein the
positioning mechanism comprises a pair of spring-loaded balls each
of which is housed in one of a pair of bores each closed at one end
and formed in the lower medicator-body portion, and a pair of
springs each of which is operably disposed in one of the bores so
as to bias the balls in a direction that causes a part of a
spherical surface of each of the balls to be protruded through an
opening end of each of the balls into the holder mounting
groove.
12. The inhalant medicator as claimed in claim 11, wherein the
holder has a plurality of recessed fit portions which are formed on
the underside of the holder for engagement with the spring-loaded
balls of the positioning mechanism.
13. The inhalant medicator as claimed in claim 7, wherein the
blister pack comprises a base panel having a blistered portion, and
a lid panel affixed onto an obverse of the base panel to define a
medical powder storage chamber by hermetically covering the
blistered portion of the base panel, the blistered portion
comprising a pair of substantially hemispherical convex portions in
which inflow and outflow holes are pricked during a preliminary
operation of inhalant medication, and a flow-constriction portion
formed between the substantially hemispherical convex portions to
define a flow-constriction orifice passage.
14. The inhalant medicator as claimed in claim 13, which further
comprises a flap valve disposed in the flow-constriction orifice
passage.
15. The inhalant medicator as claimed in claim 13, wherein the
blistered portion is formed as an elliptical convex portion having
the flow-constriction portion narrowed in a direction perpendicular
to a flat surface of the lid panel.
16. The inhalant medicator as claimed in claim 13, wherein the
blistered portion is formed as a gourd-shaped convex portion having
a narrow part narrowed at its center in a transverse direction.
17. The inhalant medicator as claimed in claim 7, wherein the
blister pack comprises a base panel having a blistered portion, and
a lid panel affixed onto an obverse of the base panel to define a
medical powder storage chamber by hermetically covering the
blistered portion of the base panel, the blistered portion
comprising a pair of shallow pricked portions in which inflow and
outflow holes are pricked during a preliminary operation of
inhalant medication, and a medical powder collecting portion deeply
recessed between the shallow pricked portions to pre-store medical
powder therein.
18. The inhalant medicator as claimed in claim 7, wherein the
blister pack comprises a base panel having a blistered portion in
which inflow and outflow holes are pricked during a preliminary
operation of inhalant medication, and a lid panel affixed onto an
obverse of the base panel to define a medical powder storage
chamber by hermetically covering the blistered portion of the base
panel, the blistered portion comprising a sloped surface which
defines a shallow portion at a side of the inflow hole and defines
a deep portion at a side of the outflow hole.
19. The inhalant medicator as claimed in claim 7, wherein the
blister pack comprises a base panel having a blistered portion in
which inflow and outflow holes are pricked during a preliminary
operation of inhalant medication, and a lid panel affixed onto an
obverse of the base panel to define a medical powder storage
chamber by hermetically covering the blistered portion of the base
panel, the blistered portion comprising a sloped surface which
defines a shallow portion at a side of the outflow hole and defines
a deep portion at a side of the inflow hole.
20. An inhalant medicator comprising: a medicator body including a
holder mounting portion at one axial end and an inhalant port at
the other axial end for inhalation of medical powder; a holder
detachably rotatably mounted to the holder mounting portion and
holding thereon a blister pack having a plurality of medical powder
storage chambers spaced apart from each other in a circumferential
direction thereof; the medicator body having a portion defining an
inflow air passage to supply atmosphere toward one of the plurality
of medical powder storage chambers of the blister pack held on the
holder which is mounted to the holder mounting portion; the
medicator body having a portion defining an outflow air passage to
flow out the medical powder stored in the one medical powder
storage chamber of the blister pack held on the holder toward the
inhalant port; a pricking means attached to the medicator body for
pricking an inflow hole and an outflow hole in the one medical
powder storage chamber of the blister pack during a preliminary
operation of inhalant medication, so that the inflow hole is
fluidly communicated with the inflow air passageway and the outflow
hole is fluidly communicated with the outflow air passageway; and
the pricking means comprising a pair of parallel pins spaced apart
from each other by a predetermined distance smaller than a
longitudinal length of each of the medical powder storage chambers
of the blister pack; and the inflow and outflow holes are spaced
apart from each other by the predetermined distance to produce
turbulent air flow within the one medical powder storage chambers
of the blister pack during the inhalant medication in which the
medical powder is inhaled.
Description
TECHNICAL FIELD
[0001] The present invention relates to an inhalant medicator
suitable to prescribe granular or powdered medicines toward within
lungs of a patient by way of breathing action of the patient, and
particularly to a blister pack suitable for the inhalant
medicator.
BACKGROUND ART
[0002] Generally, there are two medications of prescribing medical
powder toward within lungs of an asthmatic patient, that is, one
being a medication that a medicine is inhaled by way of a liquid
aerosol atomizer, and the other being an inhalation treatment by
way of which granular or powdered medicines (which will be
hereinafter referred to as "medical powder") encapsulated in a
capsule or stored in a medical powder storage chamber are
inhaled.
[0003] Of these medications for an asthmatic patient, an inhalant
medicator used for an inhalation treatment where a dose of medical
powder is inhaled, is generally constructed by a medicator body
including a capsule housing chamber (or a medical powder storage
chamber) at one axial end and equipped at the other axial end with
an inhalant port through which the medical powder is inhaled, an
air passageway communicating the inhalant port with the atmosphere
via the capsule housing chamber, and a pricking tool which provided
for pricking holes in the capsule accommodated in the capsule
housing chamber.
[0004] In recent years, there have been proposed and developed
various inhalant medicators utilizing a blister pack having a set
of blisters (a plurality of blistered medical powder storage
chambers) spaced apart from each other in the circumferential
direction, for inhalant medication. Such inhalant medicators have
been disclosed in Japanese Patent Provisional Publication Nos.
59-88158 and 62-41668. The inhalant medicator as disclosed in the
Japanese Patent Provisional Publication Nos. 59-88158 and 62-41668,
includes a blister pack holder which holds a blister pack having a
plurality of blisters circumferentially spaced apart from each
other. The blister pack holder is rotatably mounted to a medicator
body. Also, the blister pack installed on the holder consists of a
base panel formed with a large number of blistered portions, a lid
panel affixed onto the principal surface of the base panel and
defining a plurality of medical powder storage chambers by
hermetically covering the blistered portions of the base panel. A
dose of medical powder is stored in each of the medical powder
storage chambers. In order to prescribe or administer the medical
powder toward within lungs of a patient by way of breathing action,
first, the blister pack is installed on the pack holder of the
inhalant medicator. Second, holes needed to intercommunicate the
atmospheric side and the inhalant port via the internal space of
the medical powder storage chamber are pricked by means of a single
plunger having a needle-shaped pricking tip. Under these
conditions, when the patient draws his or her breath while taking
the inhalant port in his or her mouse, air flow directed from the
pricked holes through the medical powder storage chamber into the
inhalant port enables medical powder stored in the medical powder
storage chamber to be carried into the inhalant port. In this
manner, medical powder stored in the storage chamber can be inhaled
through the inhalant port into lungs of the patient. In order to
continuously perform inhalant medication, the blister pack is
rotated by a predetermined angle together with the blister pack
holder, and then the next medical powder storage chamber of the
same blister pack is set at the pricking position. Thereafter, in
the same manner described previously, a series of inhalant
medication procedures are made. Thus, it is possible to
consecutively dose a patient with a specified amount of medical
powder by rotation of the blister pack holder without exchanging a
capsule.
[0005] However, in the inhalant medicators as disclosed in the
Japanese Patent Provisional Publication Nos. 59-88158 and 62-41668,
in order to prick holes in the medical powder storage chamber of
the blister pack, a single needle-shaped plunger is used as the
pricking tool. Thus, two holes, penetrating the medical powder
storage chamber aligned to each other in a direction perpendicular
to upper and lower surfaces of the blister pack, are pricked or
pierced in one blistered portion of the blister pack. Air
introduced into the medical powder storage chamber (the blistered
portion) flows straight through the medical powder storage chamber
from one (the inflow side) of the two pricked holes to the other
(the outflow side). Actually, various sorts of medical powder
having different characteristics or properties, such as a
condensation property, a particle size (fine powder, granule, or
the like) are used.
SUMMARY OF THE INVENTION
[0006] In the previously-described inhalant medicator with a single
needle-shaped plunger, it is impossible to adequately diffuse
medical powder in a medical powder storage chamber of a blister
pack by way of such straight air flow (directed from one pricked
hole to the other) in which there is less turbulence and thus the
air stream direction is almost same, and which has a substantially
constant flow velocity. Thus, some medical powder may be
undesirably left in the medical powder storage chamber after
prescribing the medical powder toward within lungs of a patient by
breathing action. As a result of this, the patient cannot inhale a
specified amount of medical powder into the lungs, thus lowering
medical benefits of powdered or granular medicines.
[0007] Accordingly, it is an object of the invention to provide an
inhalant medicator, which avoids the aforementioned
disadvantages.
[0008] It is another object of the invention to provide an inhalant
medicator, which is capable of prescribing a specified amount of
medical powder toward within lungs of a patient, while
satisfactorily diffusing the medical powder stored in a medical
powder storage chamber of a blister pack.
[0009] It is a still further object of the invention to provide a
blister pack suitable for an inhalant medicator, which enhances a
medication efficiency, effectively diffusing medical powder stored
in a medical powder storage chamber of the blister pack depending
on characteristics or properties of the medical powder, such as a
strong condensation property, and a particle size.
[0010] In order to accomplish the aforementioned and other objects
of the present invention, an inhalant medicator comprises a
medicator body including a holder mounting portion at one axial end
and an inhalant port at the other axial end for inhalation of
medical powder, a holder detachably rotatably mounted to the holder
mounting portion and holding thereon a blister pack having a
plurality of medical powder storage chambers spaced apart from each
other in a circumferential direction thereof, the medicator body
having a portion defining an inflow air passage to supply
atmosphere toward one of the plurality of medical powder storage
chambers of the blister pack held on the holder which is mounted to
the holder mounting portion, the medicator body having a portion
defining an outflow air passage to flow out the medical powder
stored in the one medical powder storage chamber of the blister
pack held on the holder toward the inhalant port, and a pricking
tool attached to the medicator body to prick an inflow hole and an
outflow hole in the one medical powder storage chamber of the
blister pack, so that the inflow hole is fluidly communicated with
the inflow air passageway and the outflow hole is fluidly
communicated with the outflow air passageway. The inflow and
outflow holes are spaced apart from each other by a predetermined
distance between a downstream end of the inflow air passageway and
an upstream end of the outflow air passageway. It is preferable
that the medicator body may comprise upper and lower medicator-body
portions and a joining portion through which the upper and lower
medicator-body portions are formed integral with each other, the
upper and lower medicator-body portions defining therebetween a
holder mounting groove which opens to three directions, and the
holder comprising a disc-shaped holder so that the disc-shaped
holder is inserted into and removed from within the holder mounting
groove. More preferably, the medicator body has a protruded portion
formed on the lower medicator-body portion which is a center of
rotation of the holder, and the holder has a plurality of recessed
fit portions each of which is formed on an upside of the holder and
is fitted to one of the plurality of medical powder storage
chambers of the blister pack, and the holder has a portion defining
a guide groove which is formed on an underside of the holder to
guide the protruded portion to the center of rotation of the
holder. It is preferable that the inhalant medicator may further
comprise a positioning mechanism provided between the holder
mounting portion of the medicator body and the holder, for
positioning the one medical powder storage chamber of the blister
pack held on the holder at a predetermined pricking position of the
pricking tool. More preferably, the positioning mechanism comprises
a spring-loaded ball housed in a bore formed in the medicator body
and closed at one end, and a spring operably disposed in the bore
so as to bias the ball in a direction that causes a part of a
spherical surface of the ball to be protruded through an opening
end of the bore into the holder mounting groove.
[0011] According to another aspect of the invention, an inhalant
medicator comprises a medicator body including a holder mounting
portion at one axial end and an inhalant port at the other axial
end for inhalation of medical powder, a holder detachably rotatably
mounted to the holder mounting portion and holding thereon a
blister pack having a plurality of blistered portions spaced apart
from each other in a circumferential direction thereof, the
medicator body having a portion defining a pair of inflow air
passages to supply atmosphere toward one of the plurality of
blistered portions of the blister pack held on the holder which is
mounted to the holder mounting portion, the medicator body having a
portion defining a pair of outflow air passages to flow out the
medical powder stored in the one blistered portion of the blister
pack held on the holder toward the inhalant port, a pricking tool
attached to the medicator body and having a pair of pins to prick
upper and lower inflow holes and upper and lower outflow holes in
the one blistered portion of the blister pack, so that the upper
inflow hole is fluidly communicated with a first one of the inflow
air passageways, the lower inflow hole is fluidly communicated with
the second inflow air passageway, the upper outflow hole is fluidly
communicated with a first one of the outflow air passageways, the
lower outflow hole is fluidly communicated with the second outflow
air passageway, the upper inflow and outflow holes being spaced
apart from each other by a predetermined distance between a
downstream end of the first inflow air passage/way and an upstream
end of the first outflow air passageway, and the lower inflow and
outflow holes being spaced apart from each other by a predetermined
distance between a downstream end of the second inflow air
passageway and an upstream end of the second outflow air
passageway.
[0012] According to a further aspect of the invention, an inhalant
medicator comprises a medicator body including a holder mounting
portion at one axial end and an inhalant port at the other axial
end for inhalation of medical powder, a holder detachably rotatably
mounted to the holder mounting portion and holding thereon a
blister pack having a plurality of medical powder storage chambers
spaced apart from each other in a circumferential direction
thereof, the medicator body having a portion defining an inflow air
passage to supply atmosphere toward one of the plurality of medical
powder storage chambers of the blister pack held on the holder
which is mounted to the holder mounting portion, the medicator body
having a portion defining an outflow air passage to flow out the
medical powder stored in the one medical powder storage chamber of
the blister pack held on the holder toward the inhalant port, a
pricking means attached to the medicator body for pricking an
inflow hole and an outflow hole in the one medical powder storage
chamber of the blister pack during a preliminary operation of
inhalant medication, so that the inflow hole is fluidly
communicated with the inflow air passageway and the outflow hole is
fluidly communicated with the outflow air passageway, and the
pricking means comprising a pair of parallel pins spaced apart from
each other by a predetermined distance smaller than a longitudinal
length of each of the medical powder storage chambers of the
blister pack, and the inflow and outflow holes are spaced apart
from each other by the predetermined distance to produce turbulent
air flow within the one medical powder storage chambers of the
blister pack during the inhalant medication in which the medical
powder is inhaled.
[0013] According to a still further aspect of the invention, a
blister pack for an inhalant medicator comprises a base panel
having a blistered portion, a lid panel affixed onto an obverse of
the base panel to define a medical powder storage chamber by
hermetically covering the blistered portion of the base panel, the
blistered portion comprising a pair of substantially hemispherical
convex portions in which inflow and outflow holes are pricked
during a preliminary operation of inhalant medication, and a
flow-constriction portion formed between the substantially
hemispherical convex portions to define a flow-constriction orifice
passage. It is preferable that the blister pack may further
comprise a flap valve disposed in the flow-constriction orifice
passage.
[0014] According to another aspect of the invention, a blister pack
for an inhalant medicator comprises a base panel having a blistered
portion, a lid panel affixed onto an obverse of the base panel to
define a medical powder storage chamber by hermetically covering
the blistered portion of the base panel, the blistered portion
comprising a pair of shallow pricked portions in which inflow and
outflow holes are pricked during a preliminary operation of
inhalant medication; and a medical powder collecting portion deeply
recessed between the shallow pricked portions to pre-store medical
powder therein.
[0015] According to another aspect of the invention, a blister pack
for an inhalant medicator comprises a base panel having a blistered
portion in which inflow and outflow holes are pricked during a
preliminary operation of inhalant medication, a lid panel affixed
onto an obverse of the base panel to define a medical powder
storage chamber by hermetically covering the blistered portion of
the base panel, and the blistered portion comprising a sloped
surface which defines a shallow portion at a side of the inflow
hole and defines a deep portion at a side of the outflow hole.
[0016] According to another aspect of the invention, a blister pack
for an inhalant medicator comprises a base panel having a blistered
portion in which inflow and outflow holes are pricked during a
preliminary operation of inhalant medication, a lid panel affixed
onto an obverse of the base panel to define a medical powder
storage chamber by hermetically covering the blistered portion of
the base panel, and the blistered portion comprising a sloped
surface which defines a shallow portion at a side of the outflow
hole and defines a deep portion at a side of the inflow hole.
[0017] The other objects and features of this invention will become
understood from the following description with reference to the
accompanying drawings.
BRIEF DESCRIPTION OF THE DRAWINGS
[0018] FIG. 1 is a longitudinal cross-sectional view illustrating
one embodiment of an inhalant medicator of the invention.
[0019] FIG. 2 is a plan view illustrating the inhalant medicator of
the embodiment shown in FIG. 1.
[0020] FIG. 3 is a longitudinal cross-sectional view illustrating
details of a medicator body of the inhalant medicator shown in FIG.
1.
[0021] FIG. 4 is a longitudinal cross-sectional view of the
medicator body, taken along the line IV-IV shown in FIG. 3.
[0022] FIG. 5 is a lateral cross-sectional view illustrating the
medicator body and a positioning mechanism, taken along the line
V-V of FIG. 1.
[0023] FIG. 6 is a top view illustrating a blister pack holder (8)
mounted on the medicator body of the inhalant medicator shown in
FIG. 1.
[0024] FIG. 7 is a bottom view illustrating the blister pack holder
(8) shown in FIG. 6.
[0025] FIG. 8 is a perspective view of a blister pack (16) to be
installed on the holder of FIG. 6, as viewed from its bottom side
(its base panel side).
[0026] FIG. 9 is a longitudinal cross-sectional view illustrating
the inhalant medicator in a state where the blister pack is
installed on the holder of FIG. 6 and then the holder is mounted in
a holder mounting groove formed in the medicator body of the
inhalant medicator shown in FIG. 1.
[0027] FIG. 10 is a longitudinal cross-sectional view illustrating
the inhalant medicator in a state where medical powder stored in
the storage chamber of the blister pack (16) installed on the
holder of FIG. 6 is inhaled.
[0028] FIG. 11 is a partly enlarged longitudinal cross-sectional
view showing air flow and medical powder flow in the medical powder
storage chamber (16D) of the blister pack (16) installed on the
holder of FIG. 6.
[0029] FIG. 12 is a longitudinal cross-sectional view illustrating
another embodiment of an inhalant medicator with a blister pack
holder having a cross section different from that shown in FIG.
1.
[0030] FIG. 13 is a plan view illustrating the inhalant medicator
of the embodiment shown in FIG. 12.
[0031] FIG. 14 is a plan view illustrating a blister pack holder
(80) mounted on the medicator body of the inhalant medicator shown
in FIG. 12.
[0032] FIG. 15 is a perspective view of a blister pack (21) to be
installed on the holder of FIG. 14, as viewed from its bottom side
(its base panel side).
[0033] FIG. 16 is a bottom view illustrating details of one
blistered portion (23) of the blister pack (21) installed on the
holder of FIG. 14.
[0034] FIG. 17 is a partly enlarged longitudinal cross-sectional
view showing the blistered portion (23), a medical-powder storage
chamber (25), and a flow-constriction passage (26).
[0035] FIG. 18 is a longitudinal cross-sectional view illustrating
the inhalant medicator in a state where medical powder stored in
the storage chamber of the blister pack (21) installed on the
holder of FIG. 14 is inhaled.
[0036] FIG. 19 is a partly enlarged longitudinal cross-sectional
view showing air flow and medical powder flow in the medical powder
storage chamber (25) of the blister pack (21) installed on the
holder of FIG. 14.
[0037] FIG. 20 is a perspective view of a modified blister pack
(31), as viewed from its bottom side (its base panel side).
[0038] FIG. 21 is a partly enlarged longitudinal cross-sectional
view showing a blistered portion (33), a medical-powder storage
chamber (36), and a medical powder collecting portion (34).
[0039] FIG. 22 is a partly enlarged longitudinal cross-sectional
view showing air flow and medical powder flow in the medical powder
storage chamber of the blister pack (31) of FIG. 20, during initial
inhalation action.
[0040] FIG. 23 is a partly enlarged longitudinal cross-sectional
view showing air flow and medical powder flow in the medical powder
storage chamber of the blister pack (31) in the middle of the
inhalation action.
[0041] FIG. 24 is a perspective view of another modified blister
pack (41), as viewed from its bottom side (its base panel
side).
[0042] FIG. 25 is a partly enlarged longitudinal cross-sectional
view showing a blistered portion (43), a medical-powder storage
chamber (46), and a sloped surface (44).
[0043] FIG. 26 is a partly enlarged longitudinal cross-sectional
view showing air flow and medical powder flow in the medical powder
storage chamber of the blister pack (41) of FIG. 24, during initial
inhalation action.
[0044] FIG. 27 is a partly enlarged longitudinal cross-sectional
view showing air flow and medical powder flow in the medical powder
storage chamber of the blister pack (41) in the middle of the
inhalation action.
[0045] FIG. 28 is a perspective view of another modified blister
pack (51), as viewed from its bottom side (its base panel
side).
[0046] FIG. 29 is a partly enlarged longitudinal cross-sectional
view showing a blistered portion (53), a medical-powder storage
chamber (56), and a sloped surface (54).
[0047] FIG. 30 is a partly enlarged longitudinal cross-sectional
view showing air flow and medical powder flow in the medical powder
storage chamber of the blister pack (51) of FIG. 28, during initial
inhalation action.
[0048] FIG. 31 is a partly enlarged longitudinal cross-sectional
view showing air flow and medical powder flow in the medical powder
storage chamber of the blister pack (51) in the middle of the
inhalation action.
[0049] FIG. 32 is a partly enlarged longitudinal cross-sectional
view showing another modified blister pack (61), particularly a
blistered portion (63), a lid panel (64), a medical powder storage
portion (65), a flow-constriction passage (66), and a flap valve
(67).
[0050] FIG. 33 is a perspective view of a still further modified
blister pack with a plurality of guitar-shaped blistered portions
(23'), as viewed from its bottom side (its base panel side).
DESCRIPTION OF THE PREFERRED EMBODIMENTS
[0051] Referring now to the drawings, particularly to FIGS. 1
through 11, there are shown the inhalant medicator of the first
embodiment and a blister pack 16 applied to the inhalant medicator
of the first embodiment. In FIGS. 1, 2, 9 and 10, reference sign 1
denotes an inhalant medicator assembly. The inhalant medicator
assembly 1 is mainly constructed by a medicator body 2 and an
inhalant port 7. As described later, the medicator body 2 is formed
therein with a plurality of air passageways, and also serves as a
blister pack holder mounting portion for a blister pack 16 which
will be fully described later. As best seen in FIGS. 3 through 5,
as a whole, the medicator body 2 is substantially cylindrical in
shape. To be exact, the medicator body 2 is comprised of an upper
medicator-body portion 4 having a substantially semi-circular cross
section, a lower medicator-body portion 5 having a substantially
semi-circular cross section (see FIGS. 3 and 5), and a
substantially cylindrical joining portion 3 through which the upper
and lower medicator-body portions 4 and 5 are formed integral with
each other. Joining portion 3 has an internal thread portion 3A
into which an external thread portion 7A of the inhalant port 7 is
screwed. Upper and lower medicator-body portions 4 and 5, each
having the substantially semi-circular cross section, are
constructed in such a manner as to axially extend from the joining
portion 3, so that their opposed flat surfaces, namely a ceiling
wall surface 6B of a holder mounting groove 6 (described later) and
a bottom surface 6C of the holder mounting groove 6, are parallel
to each other and spaced apart from each other by a predetermined
aperture (see FIGS. 3 and 5). Medicator body 2 is also formed with
the blister pack holder mounting groove 6 defined between upper and
lower medicator-body portions 4 and 5. As a whole, the medicator
body 2 is substantially cylindrical in shape. As clearly shown in
FIGS. 1, 3 and 5, the upper medicator-body portion 4 is formed with
a pricking tool guide 4A capable of slidably supporting or guiding
a support portion 13 of a pricking tool (pricking means) 12
(described later). The holder mounting groove 6 is defined between
upper and lower medicator-body portions 4 and 5 by three surfaces,
namely an innermost end surface 6A forming part of the joining
portion 3, the ceiling wall surface 6B corresponding to the
underside of upper medicator-body portion 4, and the bottom surface
6C corresponding to the upside of lower medicator-body portion 5.
As viewed from the axial direction of the inhalant port 7, the
holder mounting groove 6 opens to three directions, that is,
leftwards and rightwards, and in one axial direction of the
medicator body. The innermost end surface 6A of the groove 6 is
formed into a concave circular-arc shape that fits the contour of
the outer periphery of a blister pack holder 8 (see FIG. 4). The
predetermined aperture defined between the ceiling wall surface 6B
and the bottom surface 6C is dimensioned to be somewhat greater
than the thickness dimension of the holder 8 (see FIG. 1). The
lower medicator-body portion 5 is formed with a protruded portion
6D extending upwards from a substantially central portion of the
bottom surface 6C of holder mounting groove 6, such that the axis
of the protruded portion 6D is perpendicular to the bottom surface
6C. The protruded portion 6D functions as a center of rotation (or
an axis of rotation) of the blister pack holder 8. The protruded
portion 6D is engaged with a guide groove 8E formed in the holder
8, when mounting the holder 8 into the groove 6. Inhalant port 7 is
screwed into the other axial end of medicator body 2, and is
substantially cylindrical hollow in shape. The top end (the
left-hand side axial end of the inhalant medicator assembly 1 shown
in FIG. 1) of inhalant port 7 is configured in a manner so as to
gradually diametrically small-sized in the other axial direction.
As shown in FIG. 1, the root portion of inhalant port 7 is formed
nearby the external thread portion 7A with a plurality of
radially-extending auxiliary air passageways 7B, 7B, . . . (only
two auxiliary air passageways 7B and 7B are shown in FIG. 1, for
the purpose of illustrative simplicity). Each of the auxiliary air
passageways 7B serves to avoid difficulty in breathing action by
increasing a quantity of air flowing through the inhalant medicator
during the breathing action. As can be appreciated from the cross
section shown in FIG. 1, the inhalant port 7 is installed on the
other axial end of the medicator body by screwing the external
thread portion 7A of inhalant port 7 into the internal thread
portion 3A of joining portion 3 of the medicator body. On the other
hand, the blister pack holder 8 is detachably rotatably mounted
into the groove 6 of medicator body 2, so that the disc-shaped
holder 8 is easily inserted into and removed from within the groove
6. When the innermost end of the guide groove 8E of the holder
engages with the protruded portion 6D of the medicator body, the
holder 8 is rotatable about the protruded portion 6D. As clearly
shown in FIGS. 6 and 7, the holder 8 has a substantially disc
shape. As can be seen from the top view shown in FIG. 6, the holder
8 is formed on its upside with eight recessed fit portions 8A, 8A,
. . . , 8A circumferentially spaced apart from each other by 45
degrees and located near its circumference. In the inhalant
medicator of the first embodiment, the eight recessed fit portions
8A are configured or formed as eight radially-elongated,
substantially semi-cylindrical cavities. Eight blistered portions
16B of blister pack 16 (described later) are integrally fitted into
the respective eight recessed fit portions 8A of holder 8. The
holder 8 is formed in each of recessed fit portions 8A with an
inflow pin insertion hole (a radially inward pin insertion hole) 8B
and an outflow pin insertion hole (a radially-outward pin insertion
hole) 8C spaced apart from each other in the radial direction of
the holder 8 (viewing FIG. 6), so that two pin insertion holes 8B
and 8C penetrate the disc-shaped holder 8 in a direction
perpendicular to upper and lower surfaces of the holder 8. As
viewed from the top view of FIG. 6 and from the bottom view of FIG.
8, and as can be appreciated from the circumferentially-spaced
layout of eight radially-elongated recessed fit portions 8A, eight
pairs of radially-aligned inward and outward pin insertion holes
(8B, 8C) are also circumferentially spaced apart from each other by
45 degrees. As viewed from the bottom view shown in FIG. 7, the
holder 8 is also formed with eight recessed fit portions 8D, 8D, .
. . , 8D. The recessed fit portions 8D are formed as eight small
spherical bowl cavities. In the shown embodiment, the number of the
recessed fit portions 8D is an even number, for easy but reliable
engagement between one diametrically-opposed pair (8D, 8D) of the
eight recessed fit portions and a pair of spring-loaded balls (9A,
9A) of a positioning mechanism 9 (described later). As fully
described later, a positioning mechanism (positioning means) 9 is
provided between the holder 8 and the blister pack holder mounting
portion of the medicator body for positioning one of the medical
powder storage chambers of the blister pack installed or held on
the holder 8 at a predetermined pricking position. A pair of
spherical ball portions (9B, 9B) included in the positioning
mechanism 9 are easily fitted to one diametrically-opposed pair
(8D, 8D) of the eight recessed fit portions. Such easy fit between
two spherical ball portions (9B, 9B) and diametrically-opposed pair
(8D, 8D) ensures easy rotation of the holder 8 about the protruded
portion 6D (serving as the axis of rotation of the holder 8) and is
produced by proper mechanical snap action during rotary motion of
the holder. In the shown embodiment, two spherical ball portions
(9B, 9B) are comprised of spring-loaded balls included in the
positioning mechanism 9 (described later). The eight recessed fit
portions 8D (eight small spherical bowl cavities) are located
around the center of the holder 8. Each of recessed fit portions 8D
is located on a straight line including two centers of the
associated radially-aligned inward and outward pin insertion holes
8B and 8C. The eight recessed fit portions 8D are also
circumferentially spaced apart from each other by 45 degrees. The
holder 8 is also formed on the underside with the guide groove 8E
radially extending from the center of rotation of the holder 8. The
guide groove 8E is formed to guide the protruded portion 6D of the
holder mounting groove 6 toward the center of rotation of the
holder 8. The holder 8 is inserted or mounted into the holder
mounting groove 6 in accordance with the following procedures.
First, the guide groove 8E is engaged with the protruded portion 6D
under a condition where the blister pack 16 is installed on and
fitted to the upside of the holder 8. Thereafter, the holder 8
installing thereon the blister pack 16, is inserted into the holder
mounting groove 6 of medicator body 2, until the innermost end of
the guide groove 8E of the holder reaches the protruded portion 6D
of the medicator body. As best seen in FIGS. 4 and 5, a component
part denoted by 9 is the positioning mechanism (or positioning
means). The positioning mechanism 9 includes a pair of
spring-loaded ball housing bores (9A, 9A) each closed at one end.
The bores (9A, 9A) are point-symmetrical with respect to the
protruded portion 6D and formed in the bottom surface 6C (lower
medicator-body portion 5) of holder mounting groove 6. The
positioning mechanism 9 also includes two spring-loaded spherical
balls (9B, 9B) housed in the respective ball housing bores (9A, 9A)
in an unremovable fashion so that the inside diameter of the
opening end of each spring-loaded ball housing bore 9A is slightly
less than the inside diameter of the other portion of the bore 9A,
and two coil springs (9C, 9C), each operably disposed in the ball
housing bore 9A in a manner so as to permanently bias the
associated ball 9B in a direction that causes a part of the
spherical surface of the ball 9B to be slightly protruded from the
bottom surface 6C through an opening end of the bore 9A into the
groove 6 of medicator body 2. In the shown embodiment, the
positioning mechanism 9 is comprised of a snap-action mechanism
with a pair of spring-loaded balls (9B, 9B). With the
previously-noted arrangement of the positioning mechanism 9, when
the holder 8 is rotated under a condition where the holder 8 has
been mounted into the groove 6 of medicator body 2, the two
spring-loaded balls (9B, 9B) can be brought into engagement with
the respective recessed fit portions (8D, 8D) of the holder 8. By
way of the engagement between the two spring-loaded balls (9B, 9B)
and the recessed fit portions (8D, 8D) with the rotary motion of
the holder 8, one of eight radially-elongated recessed fit portions
8A (that is, one of eight medical powder storage chambers 16D of
blister pack 16) is efficiently reliably positioned in a
predetermined pricking position of the pricking tool 12 (or in a
set position for inhalant medication). Reference sign 10 denotes an
inflow air passageway through which the atmosphere (outside air)
can be introduced into or directed toward within the recessed fit
portion 8A of the holder 8. The inflow air passageway 10 includes
an upper axially-extending air passage 10A which is bored or formed
in the upper medicator-body portion 4, and whose one axial end
opens at one axial end of the upper medicator-body portion 4 to the
atmosphere. In a similar manner, the inflow air passageway 10
includes a lower axially-extending air passage 10B which is bored
or formed in the lower medicator-body portion 5, and whose one
axial end opens at one axial end of the lower medicator-body
portion 5 to the atmosphere. The inflow air passageway 10 also
includes a radially-extending pin insertion hole 10C formed in the
medicator body 2 so that the pin insertion hole 10C radially
extends from the pricking tool guide 4A via the upper
medicator-body portion 4 toward the lower medicator-body portion 5.
The radially-extending pin insertion hole 10C is fluidly
communicated with the other axial end of each of the upper and
lower axially-extending air passages 10A and 10B. The pin insertion
hole 10C is designed to communicate with the inflow pin insertion
hole 8B of the holder 8, when one of eight recessed fit portions 8A
of the holder 8 is positioned in the pricking position. On the
other hand, reference sign 11 denotes an outflow air passageway
through which medical powder stored in the medical powder storage
chamber 16D of the blister pack 16 flows into the inhalant port 7.
The outflow air passageway 11 includes a pin insertion hole 11A, an
upper outflow air passage 11B, and a lower outflow air passage 11C.
The pin insertion hole 11A radially extends in parallel with the
pin insertion hole 10C of the inflow air passageway 10. The upper
outflow air passage 11B axially extends from the upper
medicator-body portion 4 via the joining portion 3 toward the
inhalant port 7. One axial end of the upper outflow air passage 11B
is fluidly communicated with the pin insertion hole 11A, whereas
the other axial end opens to the interior space of the inhalant
port 7. In a similar manner, one axial end of the lower outflow air
passage 11C is fluidly communicated with the pin insertion hole
11A, whereas the other axial end opens to the interior space of the
inhalant port 7. In FIG. 1, a component part denoted by reference
sign 12 is the pricking tool used to prick holes in the blister
pack 16. As shown in FIG. 1, the pricking tool 12 includes the
support portion 13 whose outer periphery is slidably supported or
guided by a cylindrical inner peripheral wall of the pricking tool
guide 4A, and a pair of parallel pins (14, 14) whose root portions
are fixedly connected to the support portion 13, and whose tips are
inserted into the respective pin insertion holes 10C and 11A. The
pair of parallel pins are spaced apart from each other by a
predetermined distance smaller than a longitudinal length of each
of the blistered portions of the blister pack. The pricking tool 12
also includes a return spring 15 operably disposed between the
support portion 13 and the upper medicator-body portion 4 for
permanently biasing the support portion 13 and the pins (14, 14)
toward their initial positions. When the pricking action is
performed, a patient pushes the support portion 13 of pricking tool
12 into the pricking tool guide 4A against the bias of the spring
15, and thus the two pins (14, 14) are deeply inserted into the
respective pin insertion holes 10C and 11A. Thus, the tips of pins
(14, 14) penetrate the blister pack 16. As a result of this, two
inflow holes or two inflow ports (H1, H1) and two outflow holes or
two outflow ports (H2, H2) are pricked respectively in the
blistered portion 16B of a base panel 16A and a lid panel 16C of
blister pack 16 (see FIGS. 10 and 11), so that two inflow holes
(H1, H1) and two outflow holes (H2, H2) are pricked in a
perpendicular to the upper surface of the lid panel of the blister
pack, and two inflow holes (H1, H1) and two outflow holes (H2, H2)
are spaced apart from each other by a predetermined distance which
corresponds to a distance between the downstream end of the inflow
air passage and the upstream end of the outflow air passageway. As
detailed hereunder, eight blistered portions 16B of the base panel
16A define eight medical powder storage chambers 16D in conjunction
with the lid panel 16C. After pricking, as soon as the pushing
force applied to the support portion 13 is removed, the support
portion 13 and the two pins (14, 14) are returned back to their
initial positions.
[0052] Referring now to FIGS. 8 and 9, there is shown the detailed
structure of the blister pack 16 applied to the inhalant medicator
of the first embodiment. As shown in FIGS. 8 and 9, blister pack 16
is comprised of base panel 16A and lid panel 16C affixed onto the
principal surface (or the obverse) of base panel 16A. The base
panel 16A has a thin-walled disc shape and is made of synthetic
resin, aluminum material, or the like. As best seen in FIG. 8, the
base panel 16A has a plurality of blistered portions 16B, 16B, . .
. , 16B (in the first embodiment, eight blistered portions) around
its entire circumference. On the other hand, the lid panel 16C has
a thin-walled disc shape and is made of synthetic resin, aluminum
material, or the like. The blistered portions 16B formed in the
base panel 16A are located near the circumference of the base panel
16A, and formed as eight radially-elongated, substantially
semi-cylindrical convex portions. The eight blistered portions 16B
are circumferentially spaced apart from each other by 45 degrees.
By hermetically covering or closing the base panel 16A having eight
blistered portions 16B by the lid panel 16C, eight medical powder
storage chambers 16D are defined between the eight blistered
portions 16B of base panel 16A and the lid panel 16C. Actually, a
predetermined amount of medical powder, such as granular medicine
or powdered medicine is stored in each of the medical powder
storage chambers 16D.
[0053] The inhalant medicator of the first embodiment is
constructed as previously discussed. Hereinbelow described in
detail in reference to FIGS. 9-11 are the preliminary operation of
inhalant medication through which a patient inhales medical powder,
and the flow of air and the flow of medical powder during
inhalation.
[0054] First of all, blister pack holder 8 is removed from the
holder mounting groove 6 of medicator body 2. During removal of the
holder 8, the guide groove 8E, formed in the underside of the
holder and radially outwardly extending from the center of the
holder, must be axially aligned with respect to the axis of the
medicator body 2 under a condition in which the outermost end of
guide groove 8E faces the inhalant port 7. Then, the holder 8 can
be removed from the medicator body 2 by pulling the holder 8
against the bias produced by the two spring-loaded balls 9B of the
positioning mechanism 9. Then, blister pack 16 is fitted to and
installed on the upside of holder 8, such that eight blistered
portions 16B of the blister pack are fitted to respective recessed
fit portions 8A of the holder 8. At this time, by fitting the
blistered portions 16B (the medical powder storage chambers 16D) to
the respective recessed fit portions 8A, the blister pack 16 can be
integrally connected to and reliably positioned with respect to the
holder 8, and thus the blister pack 16 is rotatable together with
the holder 8. After the blister pack 16 has been installed on the
holder 8, the holder 8 is mounted into the holder mounting groove
6. In this case, the guide groove 8E must be aligned with the axis
of the medicator body 2 so that the outermost end of the guide
groove 8E is directed toward the inhalant port 7, and also the
protruded portion 6D must be engaged with the guide groove 8E. In
this manner, after the holder 8 has been completely pushed into the
holder mounting groove 6 until the innermost end of the guide
groove 8E engages with the protruded portion 6D, two balls (9B, 9B)
of the positioning mechanism 9 are engaged with the two
diametrically-opposed, small recessed fit portions 8D of the holder
8 by rotating the holder 8 in an arbitrary direction. By way of a
series of preliminary setting operations as discussed above, as
shown in FIG. 9, it is possible to accurately position one of the
medical powder storage chambers 16D of blister pack 16 at the
predetermined pricking position (the set position for inhalant
medication).
[0055] Hereunder described in detail is the actual operation of
inhalant medication made by virtue of breathing action of a
patient. First of all, in order to prick holes in the blister pack
16 held at the predetermined pricking position, the support portion
13 of pricking tool 12 is pushed or depressed. As shown in FIGS. 10
and 11, two opposed inflow holes (H1, H1) communicating inflow air
passageway 10 are pricked in the blistered portion 16B of base
panel 16A and in the lid panel 16C by means of one of the two pins
(14, 14) inserted into the pin insertion hole 10C, and at the same
time two opposed outflow holes (H2, H2) communicating outflow air
passageway 11 are pricked in the blistered portion 16B of base
panel 16A and in the lid panel 16C by means of the other pin 14
inserted into the pin insertion hole 11A. As a result, the medical
powder storage chamber 16D of blister pack 16 is communicated
through the inflow holes (H1, H1) with the inflow air passageway
10, and also communicated through the outflow holes (H2, H2) with
the outflow air passageway 11. Under these conditions, when the
patient draws his or her breath while taking the inhalant port 7 in
his or her mouse, air (atmosphere) passes through the inflow air
passageway 10 via the two inflow holes (H1, H1) and then flows into
the medical powder storage chamber 16D. At this time, the air flow
introduced via the inflow holes (H1, H1) into the medical powder
storage chamber 16D is brought into collision with the inner wall
surface of medical powder storage chamber 16D, because the inflow
holes (H1, H1) and the outflow holes (H2, H2) are spaced apart from
each other in the axial direction of the medicator body (or in the
longitudinal direction of the blistered portion of the blister
pack) by a distance between the two pin insertion holes 8B and 8C,
thereby resulting in turbulent flow within the medical powder
storage chamber 16D. Thus, the medical powder stored in the chamber
16D can be effectively diffused or micronized by means of the
turbulent flow. As a consequence, it is possible to effectively
flow out almost all of the medical powder pre-stored in the storage
chamber 16D through the outflow holes (H2, H2) and the outflow air
passageway 11 into the inhalant port 7 by virtue of the turbulent
air flow. As discussed above, during breathing action, the patient
can inhale a specified amount of medical powder via his or her oral
cavity and trachea into lungs with the aid of the turbulent air
flow. In this manner, the first inhalant medication can be
completed. Subsequently to the above, when the second inhalant
medication is needed, the holder 8 is first rotated from the
current angular position by 45 degrees. The next
diametrically-opposed recessed fit portions 8D of holder 8 are thus
engaged with the two spring-loaded balls 9B of positioning
mechanism 9. After this, through the previously-noted pricking
operation and inhaling operation, it is possible to inhale medical
powder pre-stored in the other medical powder storage chamber 16D.
In this manner, eight inhalant medications in total can be
continuously made. After the eight inhalant medications in total
have been made, the holder 8 is removed from the medicator body 2,
and then the old blister pack is replaced with a new blister pack
for the next inhalation medication.
[0056] As set forth above, according to the inhalant medicator of
the first embodiment, the inflow holes (H1, H1) communicating the
inflow air passageway 10 and the outflow holes (H2, H2)
communicating the outflow air passageway can be formed or pricked
in the blister pack by means of two pins (14, 14) fixedly connected
to the pricking tool 12, so that the inflow holes (H1, H1) and the
outflow holes (H2, H2) are spaced apart from each other by a
predetermined distance corresponding to a distance between the axes
of two pins (14, 14). As a result of this, air flowing via the
inflow holes (H1, H1) toward the outflow holes (H2, H2) is not
directed straight, but brought into collision with the inner wall
of the medical powder storage chamber. Turbulent air flow is thus
produced within the medical powder storage chamber by the air flow
directed from two inflow holes (H1, H1) via the internal space of
the medical powder storage chamber to two outflow holes (H2, H2).
Therefore, it is possible to effectively diffuse or micronize
medical powder stored in the medical powder storage chamber by
virtue of the turbulent air flow occurring in the medical powder
storage chamber owing to the two inflow holes and two outflow holes
pricked in both the base panel and lid panel of the blister pack by
the two parallel pins during inhalation treatment of air/medical
powder mixture. As a result of this, it is possible to efficiently
reliably prescribe a specified amount of medical powder pre-stored
in one of storage chambers 16D into lungs of a patient by way of
breathing action. This enhances medical benefits of the medical
powder, thereby enhancing the reliability of the inhalant
medicator. Furthermore, the holder 8 is formed on its underside
with the recessed fit portions 8D, and additionally the positioning
mechanism 9 is provided in the holder mounting groove 6 for
positioning the medical powder storage chamber 16D of blister pack
16 at the predetermined pricking position (the set position for
inhalant medication) by fitting the spring-loaded balls (9B, 9B) to
the recessed fit portions (8D, 8D). Thus, it is possible to easily
accurately position the medical powder storage chamber 16D of
blister pack 16 at the predetermined pricking position. In other
words, it is possible to accurately prick holes (H1, H1, H2, H2) in
the blistered portion of base panel 16A of blister pack 16 and in
the lid panel 16C, thus ensuring easy handling of the inhalant
medicator. Moreover, in the inhalant medicator assembly 1 of the
first embodiment, the medicator body 2 is constructed by not only
upper and lower medicator-body portions 4 and 5, but also joining
portion 3 interconnecting the upper and lower medicator-body
portions 4 and 5, and also the holder mounting groove 6 is simply
defined between the upper and lower medicator-body portions. Such a
holder mounting groove structure is so simple. The inhalant
medicator of the embodiment is designed to be easily assembled by
mounting the disc-shaped blister pack holder 8 into the holder
mounting groove 6 being simple in structure, thus reducing the
number of parts of the inhalant medicator assembly. This ensures
ease of assembly, and also reduces total production costs of the
inhalant medicator. Additionally, the disc-shaped holder 8 is
formed on its upside with circumferentially equally spaced,
radially-elongated eight recessed fit portions 8A (eight
substantially semi-cylindrical cavities). Thus, it is possible to
accurately easily position the blister pack 16 on the holder 8 by
fitting the blistered portions 16B to the respective recessed fit
portions 8A, thus allowing the blister pack 16 to integrally rotate
together with the holder 8. This ensures ease of handling. In
addition to the above, the holder 8 is formed on its underside with
the guide groove 8E which is engageable with the protruded portion
6D of holder mounting groove 6. The guide groove 8E permits the
protruded portion 6D to be reliably easily guided to the rotation
center of the holder 8 (the innermost end of the guide groove 8E).
This ensures accurate and easy mounting of the holder 8 on the
desired position of the medicator body 2, thus ensuring ease of
handling.
[0057] Referring now to FIGS. 12 through 19, there are shown the
inhalant medicator of the second embodiment and a blister pack 21
applied to the inhalant medicator of the second embodiment. The
inhalant medicator of the second embodiment of FIGS. 12-19 is
similar to the first embodiment of FIGS. 1-11, except that the
shape of the blister pack holder 80 and the shape of the blister
pack 21 of the second embodiment are different from those of the
first embodiment. Thus, the same reference signs used to designate
elements in the first embodiment shown in FIGS. 1-11 will be
applied to the corresponding elements used in the second embodiment
shown in FIGS. 12-19, for the purpose of comparison of the first
and second embodiments. The blister pack 21 and its holder 80 of
the second embodiment will be hereinafter described in detail with
reference to the accompanying drawings, while detailed description
of elements denoted by the same reference signs will be omitted
because the above description thereon seems to be
self-explanatory.
[0058] As best seen in FIGS. 15 through 17, blister pack 21 is
comprised of a base panel 22, a lid panel 24, a medical powder
storage chamber 25, and a flow-constriction passage 26. Base panel
22 has a thin-walled disc shape and is made of synthetic resin,
aluminum material, or the like. The base panel has a plurality of
blistered portions 23, 23, . . . , 23 (in the second embodiment,
eight blistered portions) around its entire circumference. On the
other hand, lid panel 24 has a thin-walled disc shape and is made
of synthetic resin, aluminum material, or the like. The eight
blistered portions 23 are circumferentially spaced apart from each
other by 45 degrees. As best seen in FIGS. 16 and 17, the blistered
portions 23 formed in the base panel 22 are located near the
circumference of the base panel 22, and formed as eight
radially-elongated, substantially elliptical convex portions. Each
of the blistered portions 23 includes a radially-inward,
substantially hemispherical convex portion 23A and a
radially-outward, substantially hemispherical convex portion 23B,
and a flow-constriction portion 23C formed between the two
hemispherical convex portions 23A and 23B. The flow-constriction
portion 23C is configured to provide a flow-constriction orifice
passage 26 between the base panel 22 and the lid panel 24 at a
connecting point between two convex portions 23A and 23B in close
proximity to the inner wall of the lid panel 24. By hermetically
covering or closing the base panel 22 having eight blistered
portions 23 by the lid panel 24, eight medical powder storage
chambers 25 are defined between the eight blistered portions 23 of
base panel 22 and the lid panel 24. A predetermined amount of
medical powder is stored in each of the medical powder storage
chambers 24. The flow-constriction orifice passage 26 is formed in
the medical powder storage chamber 25 and arranged between the
previously-described inflow holes (H1, H1) and outflow holes (H2,
H2). The flow-constriction orifice passage 26 functions to increase
the flow velocity of air flowing from the inflow holes (H1, H1) via
the interior of the medical powder storage chamber 25 to the
outflow holes (H2, H2). Additionally, the flow-constriction orifice
passage 26 functions to cause proper turbulent flow within the
medical powder storage chamber 25 and consequent mixing action. By
suitably varying or selecting the orifice size of the
flow-constriction orifice passage 26 depending on characteristics
or properties of medical powder used, such as a strong
condensation, and a particle size, turbulent air flow suitable to
properties of medical powder can be produced. Therefore, it is
possible to effectively diffuse the medical powder by virtue of the
flow-constriction orifice passage 26 which is dimensioned and
designed to be suitable for the properties of medical powder stored
in the storage chamber 25. On the other hand, the holder 80 is
formed on its upside with eight recessed fit portions 80A, 80A, . .
. , 80A circumferentially spaced apart from each other by 45
degrees and located near its circumference. In the inhalant
medicator of the second embodiment, the eight recessed fit portions
80A are configured or formed as eight radially-elongated,
substantially elliptical cavities. Eight blistered portions 23 of
blister pack 21 are integrally fitted into the respective eight
recessed fit portions 80A of holder 80.
[0059] In the same manner as the inhalant medicator of the first
embodiment, when inhalant medication is initiated using the
inhalant medicator of the second embodiment, first, the preliminary
operation of inhalant medication is made. Inflow holes (H1, H1) and
outflow holes (H2, H2) are pricked in the blistered portion 23 of
base panel 22 and in the lid panel 24 of blister pack 21 held at
the predetermined pricking position, after a series of preliminary
setting operations have been completed. Under these conditions,
when the patient draws his or her breath while taking the inhalant
port 7 in his or her mouse, air flows through the inflow air
passage 10 and the inflow holes (H1, H1) into the storage chamber
25. At this time, air flow directed from the inflow holes (H1, H1)
to the outflow holes (H2, H2) passes through the flow-constriction
orifice passage 26. By means of the orifice passage 26, the flow
velocity of air flow passing through the orifice passage 26 is
increased, and thus causing properly strengthened turbulent flow
(see FIGS. 18 and 19). Therefore, the strengthened turbulent flow
can effectively diffuse or micronize the medical powder. As a
result of this, it is possible to effectively flow out almost all
of medical powder pre-stored in the storage chamber 25 through the
outflow holes (H2, H2) and the outflow air passageway 11 into the
inhalant port 7 by virtue of the properly-strengthened turbulent
air flow. Thus, during breathing action, the patient can inhale a
specified amount of medical powder via his or her oral cavity and
trachea into lungs by way of the properly-strengthened turbulent
air flow.
[0060] As discussed above, according to the inhalant medicator of
the second embodiment, the flow-constriction orifice passage 26 is
defined within the medical powder storage chamber 25 of blister
pack 21 by the flow-constriction portion 23C of blistered portion
23 so that the flow-constriction orifice passage 26 is located
between the inflow holes (H1, H1) and the outflow holes (H2, H2).
The flow-constriction orifice passage 26 acts to properly regulate
or control the air flow passing through the medical powder storage
chamber 25 depending on the properties or characteristics peculiar
to medical powder stored in the storage chamber 25. Therefore, it
is possible to produce turbulent air flow suitable for medical
powder stored in the storage chamber 25 by properly determining or
setting an orifice size of the flow-constriction orifice passage 26
in due consideration of characteristics or properties of the
medical powder, such as a particle size (fine powder or granule), a
condensation property (strong condensation or weak condensation),
an amount of a dose of medical powder, or the like. Therefore, it
is possible to reliably effectively prescribe a specified amount of
medical powder toward within lungs of the patient. This enhances
medical benefits of the medical powder, and also enhances the
reliability of the inhalant medicator. Additionally, the blister
pack 21, storing medical powder, has its own flow-constriction
orifice passage 26 in each of the blistered portions (or in each of
the medical powder storage chambers). Thus, it is possible to
easily form a flow-constriction orifice passage suitable for every
kind of medical powder, and thereby an efficiency of inhalant
medication can be remarkably enhanced.
[0061] Referring now to FIGS. 20 through 23, there is shown the
modified blister pack 31. As detailed hereunder, the modified
blister pack 31 shown in FIGS. 20-23 is characterized by a
deeply-recessed medical powder collecting portion 34, as viewed
from the cross section shown in FIG. 21. The blister pack 31 is
comprised of base panel 32, medical powder collecting portion 34,
lid panel 35, and medical powder storage chamber 36. The base panel
32 has a thin-walled disc shape and is made of synthetic resin,
aluminum material, or the like. As best seen in FIG. 20, the base
panel 32 has a plurality of blistered portions 33, 33, . . . , 33
(eight blistered portions) around its entire circumference. The
shape and material of the lid panel 35 of blister pack 31 are
identical to those of blister pack 16 applied to the inhalant
medicator of the first embodiment (or to those of blister pack 21
applied to the inhalant medicator of the second embodiment). The
modified blister pack 31 shown in FIGS. 20-23 is different from the
blister pack 21 shown in FIGS. 15-17, in that the shape of each
blistered portion 33 of base panel 32 differs from the shape of
each blistered portion 23 of base panel 22. As best seen in FIG.
21, the blistered portions 33 are formed as eight
radially-elongated, substantially elliptical convex portions. Each
of the blistered portions 33 includes a radially-inward, shallow
pricked portion 33A in which the previously-noted inflow hole H1 is
pricked, and a radially-outward, shallow pricked portion 33B in
which the previously-noted outflow hole H2 is pricked. The medical
powder collecting portion 34 is deeply formed or recessed in the
base panel 32 midway between the radially-inward, shallow pricked
portion 33A and the radially-outward, shallow pricked portion 33B.
The medical powder collecting portion 34 serves as an air-flow
regulation means as described later. When the blister pack 31 is
installed on the blister pack holder, the medical powder collecting
portion 34 of the blistered portion 33 serves as a deeply-recessed
medical powder collecting portion kept at a level lower than the
shallow pricked portions (33A, 33B). A portion denoted by reference
sign 36 is the medical powder storage chamber defined between the
blistered portion 33 of base panel 32 and the lid panel 35. A
predetermined amount of medical powder is stored in the medical
powder storage chamber 36, such that almost all of the medical
powder is collected or pre-stored in the medical powder collecting
portion 34. The blister pack 31 shown in FIGS. 20-23 is constructed
as previously discussed. Hereinbelow described in detail in
reference to FIGS. 22 and 23 are the flow of air passing through
the medical powder storage chamber 36 and the flow of medical
powder within the storage chamber 36 during inhalation. Inflow
holes (H1, H1) and outflow holes (H2, H2) are pricked in the
blistered portion 33 of base panel 32 and in the lid panel 34 of
blister pack 31 held at the predetermined pricking position, after
a series of preliminary setting operations have been completed.
Under these conditions, when the patient draws his or her breath
while taking the inhalant port 7 in his or her mouse, at the
initial stage of the inhaling action, air introduced through the
inflow air passage 10 via the inflow holes (H1, H1) into the
storage chamber 35, functions to fling up and diffuse a part of
medical powder located at the top of the medical powder collecting
portion 34 (see FIG. 22). The upflung and diffused portion of the
medical powder collected in the collecting portion 34 is supplied
into the outflow holes (H2, H2). When several times of inhaling
actions are repeated, the medical powder stored in the storage
chamber 36 can be gradually reduced. At this time, as clearly shown
in FIG. 23, air flow passing through the inflow holes (H1, H1)
enters the medical powder collecting portion 34, and therefore
medical powder collected in the collecting portion 34 is gradually
flung up and diffused from the uppermost portion until a lowermost
portion of the medical powder stored is flung up, and thus the
diffused medical powder is supplied into the outflow holes (H2, H2)
little by little. As discussed above, according to the structure of
the blister pack 31 having the deeply-recessed medical powder
collecting portion 34, it is possible to fling up and uniformly
diffuse the medical powder stored in the storage chamber 36 little
by little. This prevents a large amount of air/medical powder
mixture in one breath from being flown into the outflow holes (H2,
H2), thus avoiding the outflow holes from being choked up with such
a large amount of medical powder flow mass. In case that inhalant
medication is made to a patient having a weak trachea, the patient
can inhale the medical powder little by little. This prevents the
patient from getting a fit of coughing during the inhalant
medication, thus ensuring a stable medication during the breathing
action.
[0062] Referring now to FIGS. 24 through 27, there is shown another
modified blister pack 41. As detailed hereunder, the modified
blister pack 41 shown in FIGS. 24-27 is characterized by a sloped
surface 44, as viewed from the cross section shown in FIG. 25. The
blister pack 41 is comprised of base panel 42, sloped surface 44,
lid panel 45, and medical powder storage chamber 46. The blistered
portion 43 of blister pack 41 is formed with the previously-noted
sloped surface 44 such that a side of the inflow holes (H1, H1)
penetrating the radially-inward half of the blistered portion of
base panel 42 is formed as a shallow portion, whereas a side of the
outflow holes (H2, H2) penetrating the radially-outward half of the
blistered portion of base panel 42 is formed as a deep portion. As
best seen in FIG. 24, the base panel 42 has a plurality of
blistered portions 43, 43, . . . , 43 (eight blistered portions)
around its entire circumference. The shape and material of the lid
panel 45 of blister pack 41 are identical to those of blister pack
16 applied to the inhalant medicator of the first embodiment (or to
those of blister pack 31 shown in FIGS. 20-23). The modified
blister pack 41 shown in FIGS. 24-27 is different from the blister
pack 21 shown in FIGS. 15-17, in that the shape of each blistered
portion 43 of base panel 42 differs from the shape of each
blistered portion 23 of base panel 22. As best seen in FIG. 25, the
blistered portions 43 are formed as eight radially-elongated,
substantially elliptical convex portions. The radially-elongated
inward half of the blistered portion 43 is formed as a
comparatively shallow, sloped surface portion 44 (simply, a sloped
surface), while the radially-elongated outward half of the
blistered portion 43 is formed as a comparatively deep, recessed
portion (simply, a deep recess), as viewed from the cross section
shown in FIG. 25. In other words, the sloped surface 44 is
dimensioned or sloped downwards (viewing FIG. 25) so that the
convexity ratio of the blistered portion 43 radially increases from
the inside to the outside. The inflow holes (H1, H1) are pricked in
the sloped surface 44, while the outflow holes (H2, H2) are pricked
in the deep recess. The medical powder storage chamber 46 is
defined between the blistered portion 43 of base panel 42 and the
lid panel 45. A predetermined amount of medical powder is stored in
the medical powder storage chamber 46, such that almost all of the
medical powder is mainly stored in the deep recess corresponding to
the outflow holes (H2, H2) by way of the sloped surface 44. The
blister pack 41 shown in FIGS. 24-27 is constructed as previously
discussed. Hereinbelow described in detail in reference to FIGS. 26
and 27 are the flow of air passing through the medical powder
storage chamber 46 and the flow of medical powder within the
storage chamber 46 during inhalation. Inflow holes (H1, H1) and
outflow holes (H2, H2) are pricked in the blistered portion 43 of
base panel 42 and in the lid panel 44 of blister pack 41 held at
the predetermined pricking position, after a series of preliminary
setting operations have been completed. Under these conditions,
when a patient draws his or her breath while taking the inhalant
port 7 in his or her mouse, at the initial stage of the inhaling
action, air introduced through the inflow air passage 10 via the
inflow holes (H1, H1) into the storage chamber 46, flows through
the interior of the storage chamber in a manner so as to push out
the medical powder toward within the outflow holes (H2, H2) while
diffusing the medical powder mainly stored in the deep recess of
the blistered portion 43 (see FIG. 26). Thus, the air introduced
through the inflow holes (H1, H1) forcibly pushes the medical
powder towards the outflow holes (H2, H2), and thus the medical
powder stored in the storage chamber 46 is flown out of the outflow
holes (H2, H2) at a breath (see FIG. 27). According to the
structure of the blister pack 41 having the sloped surface 44 at
the inflow side thereof, it is possible to flow out the medical
powder stored in the storage chamber 46 at a breath, such that the
medical power accumulated around the outflow holes (H2, H2) is
pushed out by way of air flow directed from the inflow holes (H1,
H1) to the outflow holes (H2, H2). As a result, the patient can
inhale the medical powder stored in the storage chamber 46 for a
short time period. This reduces a burden on the patient's lungs. In
particular, the blister pack 41 shown in FIGS. 24-27 is suitable to
prescribe a relatively small amount of medical powder.
[0063] Referring now to Figs. FIGS. 28 through 31, there is shown
another modified blister pack 51. As detailed hereunder, the
modified blister pack 51 shown in FIGS. 28-31 is characterized by a
sloped surface 54, as viewed from the cross section shown in FIG.
29. The blister pack 51 is comprised of base panel 52, sloped
surface 54, lid panel 55, and medical powder storage chamber 56.
The blistered portion 53 of blister pack 51 is formed with the
previously-noted sloped surface 54 such that a side of the outflow
holes (H2, H2) penetrating the radially-outward half of the
blistered portion of base panel 52 is formed as a shallow portion,
whereas a side of the inflow holes (H1, H1) penetrating the
radially-inward half of the blistered portion of base panel 52 is
formed as a deep portion. As best seen in FIG. 28, the base panel
52 has a plurality of blistered portions 53, 53, . . . , 53 (eight
blistered portions) around its entire circumference. The shape and
material of the lid panel 55 of blister pack 51 are identical to
those of blister pack 16 applied to the inhalant medicator of the
first embodiment (or to those of blister pack 31 shown in FIGS.
20-23). The modified blister pack 51 shown in FIGS. 28-31 is
different from the blister pack 21 shown in FIGS. 15-17, in that
the shape of each blistered portion 53 of base panel 52 differs
from the shape of each blistered portion 23 of base panel 22. As
best seen in FIG. 29, the blistered portions 53 are formed as eight
radially-elongated, substantially elliptical convex portions. The
radially-elongated outward half of the blistered portion 53 is
formed as a comparatively shallow, sloped surface portion 54
(simply, a sloped surface), while the radially-elongated inward
half of the blistered portion 53 is formed as a comparatively deep,
recessed portion (simply, a deep recess), as viewed from the cross
section shown in FIG. 29. In other words, the sloped surface 54 is
dimensioned or sloped upwards (viewing FIG. 25) so that the
convexity ratio of the blistered portion 53 radially decreases from
the inside to the outside. The outflow holes (H2, H2) are pricked
in the sloped surface 54, while the inflow holes (H1, H1) are
pricked in the deep recess. The medical powder storage chamber 56
is defined between the blistered portion 53 of base panel 52 and
the lid panel 55. A predetermined amount of medical powder is
stored in the medical powder storage chamber 56, such that almost
all of the medical powder is mainly stored in the deep recess
corresponding to the inflow holes (H1, H1) by way of the sloped
surface 54. The blister pack 51 shown in FIGS. 28-31 is constructed
as previously discussed. Hereinbelow described in detail in
reference to FIGS. 30 and 31 are the flow of air passing through
the medical powder storage chamber 56 and the flow of medical
powder within the storage chamber 56 during inhalation. Inflow
holes (H1, H1) and outflow holes (H2, H2) are pricked in the
blistered portion 53 of base panel 52 and in the lid panel 54 of
blister pack 51 held at the predetermined pricking position, after
a series of preliminary setting operations have been completed.
Under these conditions, when a patient draws his or her breath
while taking the inhalant port 7 in his or her mouse, at the
initial stage of the inhaling action, air introduced through the
inflow holes (H1, H1) into the storage chamber 56 is brought into
direct-collision with the medical powder pre-stored in the deep
recess of blistered portion 53 in which the inflow holes (H1, H1)
are pricked. As a result, the medical powder is diffused within the
storage chamber 56 at a breath (see FIG. 30). Then, air flow
introduced through the inflow holes (H1, H1) acts to gradually flow
out the medical powder through the outflow holes (H2, H2) (see FIG.
31). According to the structure of the blister pack 51 having the
sloped surface 54 at the outflow side thereof, it is possible to
effectively diffuse the medical powder stored in the storage
chamber by way of direct collision between the air flow introduced
through the inflow holes (H1, H1) into the storage chamber and the
medical powder stored. Thus, the blister pack 51 functions to
uniformly disperse the medical powder into the entire air flow,
while adequately diffusing the medical powder within the storage
chamber 56. That is, the blister pack 51 permits medical powder to
be stably supplied or inhaled into the lungs of the patient little
by little.
[0064] Referring now to FIG. 32, there is shown another modified
blister pack 61. The modified blister pack 61 is characterized by a
flow-constriction orifice passage 66 and a flap valve 67. The
flow-constriction passage 66 is located between the radially inward
and outward halves of the blistered portion 63 of the blister pack
61. The flap valve 67 is disposed in the flow-constriction passage
66 so that the flap valve fully opens only in presence of a strong
inhaling action. The blister pack 61 is comprised of base panel 62,
lid panel 64, medical powder storage chamber 65, flow-constriction
passage 66, and flap valve 67. The base panel 62 has a thin-walled
disc shape and is made of synthetic resin, aluminum material, or
the like. As seen in FIG. 32, the base panel 62 has a plurality of
blistered portions 63, 63, . . . , 63 (eight blistered portions)
around its entire circumference. Each of the blistered portions 63
includes a radially-inward convex portion 63A and a
radially-outward convex portion 63B, and a flow-constriction
portion 63C provided between the two convex portions 63A and 63B.
The shape and material of the lid panel 64 of blister pack 61 are
identical to those of blister pack 21 applied to the inhalant
medicator of the second embodiment. The lid panel 64 is formed at
its inner wall with the flap valve 67 which opens and closes the
flow-constriction passage 66. By hermetically covering the base
panel 62 by the lid panel 64, eight medical powder storage chambers
65 are defined between the eight blistered portions 63 of base
panel 62 and the lid panel 64. A predetermined amount of medical
powder is stored in only the inward convex portion 63A of the two
convex portions 63A and 63B of each of the blistered portions,
before inhaling action is started. As can be appreciated from
comparison between the blister pack 21 applied to the inhalant
medicator of the second embodiment shown in FIG. 17 and the blister
pack 61 shown in FIG. 32, the blister pack 61 shown in FIG. 32 is
different from the blister pack shown in FIG. 17, in that the
flow-constriction orifice passage 26 (serving as a fixed orifice)
is replaced with the flow-constriction passage 66 and the flap
valve 67, and that medical powder is pre-stored in only the
upstream side (that is, the inward convex portion 63A) of the two
convex portions 63A and 63B. When an inhalation force (or a suction
force) of the patient is weak, the flap valve 67 is kept at its
closed position indicated by the solid line in FIG. 32, in a manner
so as to fully close the flow-constriction passage 66. Conversely,
when the patient's inhalation force becomes strong enough to
diffuse the medical powder stored in the inward convex portion 63A
and to disperse the medical powder into the downstream convex
portion 63B, the flap valve 67 is opened to permit
fluid-communication between the two convex portions 63A and 63B, as
indicated by the two-dotted line in FIG. 32. According to the
blister pack 61 having the flap valve 67 disposed in the
flow-constriction passage 66, it is possible to inhibit medical
powder from being prescribed toward within lungs of the patient in
case of a weak inhalation force. In other words, the blister pack
61 is designed to permit medical powder to be prescribed toward
within the lungs of the patient, only when a level of the
inhalation force exceeds a predetermined threshold value, and thus
an acceptable inhalation-force level that adequately diffuses the
medical powder is satisfied. Furthermore, it is possible to
intermittently or pulsatively prescribe medical powder toward
within lungs of a patient by adjusting the magnitude of the
inhalation force. As discussed above, the blister pack 61 shown in
FIG. 32 insures adequate diffusion of the medical powder, thus
enhancing an efficiency of medication.
[0065] In the first and second embodiments and all of the modified
blister packs (31; 41; 51; 61) shown and described herein, although
the inhalant medicator is exemplified in the blister pack having
eight blistered portions (or eight medical powder storage
chambers), the invention is not limited to the particular
embodiments shown and described herein. In lieu thereof, a blister
pack having two or more and seven or less blistered portions, or a
blister pack having nine or more blistered portions may be used in
the inhalant medication. In this case, the number of the recessed
fit portions (8A; 80A) of holder (8; 80), the number of the pin
insertion hole pairs (8B, 8C), and the number of small recessed fit
portions 8D must be set to be identical to the number of the
blistered portions.
[0066] Referring now to FIG. 33, there is shown a modification of
the blister pack 21 applied to the inhalant medicator of the second
embodiment shown in FIGS. 12-19. In the second embodiment, each of
the blistered portions 23 of blister pack 21 is formed as a
radially-elongated, elliptical convex portion having the
flow-constriction portion narrowed in a direction perpendicular to
a flat surface of the lid panel. In lieu thereof, as shown in FIG.
33, a blistered portion may be formed as a radially-extending,
guitar-shaped or gourd-shaped convex portion 23' having a narrow
part narrowed at its center in a transverse direction. The narrow
portion of the gourd-shaped convex portion 23' forms a greatly
reduced flow-constriction passage between the two convex portions
23A and 23B, thereby remarkably effectively increasing the flow
velocity of air flow through the orifice passage 26.
[0067] The entire contents of Japanese Patent Application Nos.
P11-352280 (filed Dec. 10, 1999) and P11-352281 (filed Dec. 10,
1999) are incorporated herein by reference.
[0068] While the foregoing is a description of the preferred
embodiments carried out the invention, it will be understood that
the invention is not limited to the particular embodiments shown
and described herein, but that various changes and modifications
may be made without departing from the scope or spirit of this
invention as defined by the following claims.
* * * * *