U.S. patent application number 10/719935 was filed with the patent office on 2005-02-17 for temperature sensitive state-changing hydrogel composition and method for preparation.
Invention is credited to Kim, Paul, Oh Yoo, Hyun, Son, Taewon, Sung, Changmo.
Application Number | 20050037079 10/719935 |
Document ID | / |
Family ID | 36168657 |
Filed Date | 2005-02-17 |
United States Patent
Application |
20050037079 |
Kind Code |
A1 |
Son, Taewon ; et
al. |
February 17, 2005 |
Temperature sensitive state-changing hydrogel composition and
method for preparation
Abstract
This invention is about temperature sensitive state-changing
hydrogel composition and its method of production that consists of
Branched Gel Polymer 1-10 wt %, Electrolyte Gel Polymer 0.5-5 wt %,
Skin-friendly Enhancements 0.5-5 wt %, Natural Bio Material 1-10 wt
%, Aliphatic Polyol 3-30 wt %, Functional Additive 1-10 wt % and
water 30-93 wt %. Temperature sensitive hydrogel composition is
produced at temperature between 10.degree. C. and 50.degree. C.,
where hydrogel transforms to a fluid state. When this invented
hydrogel composition is contacted with skin, it transforms into a
fluid state owing to body temperature. Then the ingredient or
medication in hydrogel can efficiently and evenly penetrate into
the skin.
Inventors: |
Son, Taewon; (Susung-gu,
KR) ; Oh Yoo, Hyun; (Seoul, KR) ; Sung,
Changmo; (Weston, MA) ; Kim, Paul; (Weston,
MA) |
Correspondence
Address: |
PERMAN & GREEN
425 POST ROAD
FAIRFIELD
CT
06824
US
|
Family ID: |
36168657 |
Appl. No.: |
10/719935 |
Filed: |
November 21, 2003 |
Current U.S.
Class: |
424/486 ;
424/725.1; 424/728; 424/729; 424/744; 424/752; 424/765 |
Current CPC
Class: |
A61K 2800/24 20130101;
A61K 8/0208 20130101; A61K 8/345 20130101; A61Q 19/00 20130101;
A61K 2800/594 20130101; A61K 2800/54 20130101; A61K 8/73 20130101;
A61K 8/042 20130101; A61K 9/7007 20130101; A61K 8/736 20130101;
A61K 9/06 20130101 |
Class at
Publication: |
424/486 ;
424/725.1; 424/728; 424/729; 424/752; 424/765; 424/744 |
International
Class: |
G06K 009/34; A61K
009/14; A61K 035/78 |
Foreign Application Data
Date |
Code |
Application Number |
Aug 14, 2003 |
KR |
10-2003-0056557 |
Claims
1. Temperature sensitive state-changing hydrogel composition,
comprising of; (a) branched gel polymer 1-10 wt %; (b) electrolyte
gel polymer 0.5-5 wt %; (c) skin-friendly enhancements 0.5-5 wt %;
(d) natural bio material 1-10 wt %; (e) aliphatic polyol 3-30 wt %;
(f) functional additive 1-10 wt %; and (g) water 30-93 wt %.
2. State-changing hydrogel composition according to claim 1,
wherein said the Branched gel polymer, one of the Hydrogel
ingredient, is water soluble Polysaccharide Polymers which are
selected from at least one from the group of Galactomannan,
Glucomannan, Guagum, Locastgum and Plutonic.
3. State-changing hydrogel composition according to claim 1, the
Electrolyte gel polymer, one of the Hydrogel ingredient, is the
Polysaccharide Polymers which are selected from at least one from
the group of Aga, Algin, Carrageenan, Xantan and Gelan.
4. State-changing hydrogel composition according to claim 1,
Skin-friendly enhancer, one of the Hydrogel ingredient, is selected
from at least one from the group of Polysaccharide like Chitosan,
proteoglycans, Chitosan derivative, Elastin, Collagen, Hyaluronic
Acid or other Proteins.
5. State-changing hydrogel composition according to claim 1,
Natural bio materials, one of the Hydrogel ingredient, is the
natural substance extracted from plant, animal or mineral which are
aloe, green tea, ginseng, wood vinegar, pine needles, propolis,
gingko leaves, and mulberry leaves (silkworm).
6. State-changing hydrogel composition according to claim 1,
Aliphatic Polyol, one of the Hydrogel ingredients, is liquid
Propylene glycol or liquid glycerine which are water soluble.
7. State-changing hydrogel composition according to claim 1,
Functional additive, one of the Hydrogel ingredient, is the
additive that can provide stability and beauty care functionality.
They are propilparavin, Kojic acid, .alpha.-Hydroxy acid,
imidazolidinylurea, twin80 and retinol.
8. Temperature Sensitive State-changing Hydrogel production method
is as follows: At the room temperature, mixing Aliphatic Polyol
3-30 wt % with branched gel polymer 1-10 wt % (extracted from group
of Galactomannan, Glucomannan, Guagum, Locastgum and Plutonic),
Electrolyte gel polymer 0.5-5 wt % (extracted from group of Aga,
Aglin, Carragenan, Xantan and Gelan), Functional Additive 1-10 wt %
(extracted from group of Chitosan derivative, Proteoglucan,
Elastin, Collagen and Hyaluronic acid), and adding between about
30-93 wt % water; increasing the temperature to 45.about.95.degree.
C.
Description
SHORT DESCRIPTION OF FIGURES
[0001] FIG. 1 shows the viscosity of the Hydrogel composition
measured at various temperatures.
[0002] FIG. 2 shows that the hydrogel is formed by two gel type
Polymers. Part (a) shows that physical bond of the branched polymer
and electrical bond of the electrolyte gel polymer exists together.
Part (b) shows the fluid state of the polymers where electrical
bond of the electrolyte gel polymer exists but the physical bond of
the branched gel polymer does not exist.
[0003] FIG. 3 shows the skin care hydrogel sheet that was produced
using invented hydrogel composition. Part (a) is the base that is
made out of rayon textile and part (b) is the invented
Hydrogel.
DETAILED DESCRIPTION OF THE INVENTION
Purpose of the Invention
Technical Field and Traditional Technique
[0004] This invention is about the temperature sensitive
state-changing Hydrogel composition and the method for its
preparation. In detail, it is the Hydrogel composition and its
method of production of the gel that transforms into state-changing
condition by temperature difference which can be applied
efficiently to skin as beauty care.
[0005] The state-changing Hydrogel composition means a material
Hydrogel, which contains great quantity of water, changes its form
into state of fluid at a certain temperature.
[0006] In Recent years, Hydrogel has been used in many areas of
skin-care such as cosmetic products, and dermal treatment. Hydrogel
is used as a base frame because it is suitable for the controlled
release of drugs (N. A. Pappas Ed., "Hydrogels in Medicine and
Pharmacy, Vol.11; Polymers`, CRC Press, Inc., 1987.). This means
that Hydrogel is used as a base frame with hormones such as
progesterone, and then slowly releases and controls the quantity of
the hormones into the body.
[0007] According to Sakai U.S. Pat. No. 5,344,655, a procedure to
transfer drug through skin into the body using water soluble
polymers such as Cellulose Derivative containing hydrogel has been
already introduced.
[0008] According to Fox, U.S. Pat. No. 5,405,366, the technique
used in transdermal drug delivery system using water soluble
polymers, which form an optical bridge, contained adhesive hydrogel
were introduced.
[0009] Gebner introduced in U.S. Pat. No. 4,593,053 the usage and
production method of Hydrogel that is skin friendly and pressure
sensitive.
[0010] Transdermal delivery of drugs is a technique that transfers
hormones such as Progesterone, Progestin, Estrogen, and
Testosterone into the body through the skin. This high level
medicating system slowly releases adjusted quantity of medicine
into body through transdermal from hydrogel which is attached on
the skin.
[0011] Shumiller U.S. Pat. No. 6,215,374 introduces the
composition, method, and the device of the hydrogel for efficient
transdermal delivery of drugs.
[0012] Verner U.S. Pat. No. 5,064,654 also introduces the
composition of adhesive hydrogel for transdermal delivery of
drugs.
[0013] Sapota U.S. Pat. No. 4,942,158 introduced the composition of
hydrogel that contains penetration increment additive for better
transdermal delivery of drugs.
[0014] Moreover, Rolf U.S. Pat. Nos. 6,361,790 and 6,406,712
introduced a patch and dressing method of skin application using
hydrogel.
[0015] All of the above traditional techniques apply hydrogel to
skin, but it only releases the medicine slowly to the skin from
hydrogel which is in the form of gel.
[0016] When hydrogel is in the gel state, it takes relatively long
time for the medicine to penetrate into skin, and the drug could
only be delivered to the limited area where the hydrogel directly
contacts the skin.
[0017] To overcome this disadvantage, a penetration enhancer was
added or skin friendly hydrogel was used.
[0018] Generally, unlike medical treatment on skin, when using
cosmetic product for skin care a protection device is not applied
for long time use on an area of the skin. It is rather applied for
a short period and then removed. Hydrogel is used in this skin care
system to increase effectiveness, and it is produced in sheet and
patch forms to effectively apply to the skin. However, even though
hydrogel is used, there are limitations when hydrogel is in the
form of gel. This limitation causes delay in speed and the quantity
of the drug delivery.
[0019] The friendliness between hydrogel and skin greatly effects
delivery of contained drugs or medicine in hydrogel. This means,
greater the acceptances faster and more effective delivery of the
medicine, and lesser the acceptances slower and less effective
delivery of the medicine.
[0020] When applying skincare substance contained hydrogel for
beauty treatment onto skin, it needs to be removed sooner than the
medical treatment product. That is, the beauty treatment hydrogel
needs to deliver the substance to the skin fast and effectively. To
fulfill this feature, the hydrogel needs to evenly and rapidly
deliver the substance. Therefore, an innovative hydrogel that can
fulfill the above characteristics is required.
Technical Subject of Invention
[0021] This invention is to provide the temperature sensitive
state-changing hydrogel which delivers beauty substance into the
skin evenly and rapidly. The hydrogel composition changes its state
into liquid which can flow due to body temperature after skin
contact.
[0022] Also this invention is to provide the production method of
temperature sensitive state-changing hydrogel that distributes
beauty substance onto skin evenly and rapidly.
Structure of Invention
[0023] Temperature sensitive hydrogel composition consists of
Branched Gel Polymer 1-10 wt %, Electrolyte Gel Polymer 0.5-5 wt %,
Skin-friendly Enhancements 0.5-5 wt %, Natural Bio Material 1-10 wt
%, Aliphatic Polyol 3-30 wt %, Functional Additive 1-10 wt % and
water 30-93 wt % and transforms to the state of fluid at the
temperature of 10.about.50.degree. C.
[0024] Temperature Sensitive State-changing Hydrogel has two steps
for its production.
[0025] The first step (Preparation of Gel solution): At room
temperature, mix Aliphatic polyol 3-30 wt % with Branched gel
polymer 1-10 wt % (extracted from group of Galactomannan,
Glucomannan, Guagum, Locastgum and Plutonic), Electrolyte gel
polymer 0.5-5 wt % (extracted from group of Aga, Algin,
Carrageenan, Xantan and Gelan), Functional Additive 1-10 wt %
(extracted from group of Chitosan derivative, Proteoglucan,
Elastin, Collagen and Hyaluronic acid), and 30-93 wt % water. Then
increase the temperature to 45.about.95.degree. C.
[0026] The second step: While maintaining the temperature at
45.about.95.degree. C., sequentially add Natural Bio Material 1-10
wt % (extracted from Aloe, Green Tea, Ginseng, Wood Vinegar, Pine
Needles, Gingko Leaf, Mulberry Leaf (Silkworm)), Skin-friendly
Enhancements 0.5-5 wt % (Extracted from Metilparavin,
Propilpaprvin, Kojic acid, .alpha.-Hydroxy Acid and Retinol), and
cool it down to room temperature.
[0027] Detailed instructions are explained below.
[0028] The characteristic of temperature sensitive state-changing
hydrogel composition is that it transforms from gel to liquid state
at an ideal temperature of 30-40.degree. C., generally
10-50.degree. C. Because it enhances the acceptance level between
hydrogel and skin, it delivers beauty substance or medicine evenly
and rapidly.
[0029] This invention is to construct ideal and effective method of
hydrogel that can be used in short time beauty treatment, and then
produce suitable temperature sensitive state-changing hydrogel
composition.
[0030] This temperature sensitive state-changing hydrogel
composition optimizes acceptance level between hydrogel composition
and skin when gel transforms into liquid state after a skincare
substance contained hydrogel sheet or patch is applied to skin.
[0031] And since this hydrogel composition contains natural
acceptance level enhancements, contented amount of cosmetic can be
delivered into transdermal.
[0032] Therefore this study provides new hydrogel that has
characteristic of temperature sensitive hydrogel that transforms
its state from gel to liquid when it reaches certain
temperature.
[0033] Especially, when this invented Hydrogel is used in beauty
care in a form of hydrogel sheet or patch, the body temperature
will change the hydrogel state to liquid so that it becomes a
flowable composition. This hydrogel will automatically adhere and
penetrate into the skin and increase the acceptance level
greatly.
[0034] To obtain the above characteristics, this invented hydrogel
composition includes gel substances that are comprised of tree type
and electrolyte polymers together with acceptance level enhancer
and natural bio materials to increase the acceptance level with the
skin. Also, Polyhydric Alcohol and a functional substance will be
added to give the liquid state hydrogel more flux.
[0035] Based on the total weight, Hydrogel composition consists of
Branched Gel Polymer 1-10 wt %, Electrolyte Gel Polymer 0.5-5 wt %,
Skin-friendly Enhancements 0.5-5 wt %, Natural Bio Material 1-10 wt
%, Aliphatic Polyol 3-30 wt %, Functional Additive 1-10 wt % and
water 30-93 wt %.
[0036] The inventors found out that when the above stated elements
are included in hydrogel composition in above mentioned proportion,
hydrogel composition changes its state to liquid by body
temperature when it is applied to the skin. It was also found that
because of the above characteristics, substances included in
hydrogel composition rapidly adhere and penetrate into skin.
[0037] For the invented hydrogel composition, Branched Gel Polymers
and Electrolyte Gel Polymers are used as gel type substances. The
Electrolyte Gel Polymers keeps the invented gel composition to stay
in a gel state, and in some cases it keeps invented gel composition
to stay in the gel state in room temperature (ideally between
0-30.degree. C.).
[0038] The Branched Gel Polymers acts as a substance to change the
state from solid to liquid form when the temperature increases
10-50.degree. C. (ideally 30-40.degree. C.). FIG. 2 shows the
formation of the two polymers. Part (a) shows that physical bond of
the branched gel polymer and electrical bond of the electrolyte gel
polymer exists together. Part (b) shows the liquid state of the
polymers where electrical bond of the electrolyte gel polymer
exists but the physical bond of the branched gel polymer does not
exist.
[0039] The Branched gel polymers are water soluble Polysaccharide
Polymers which are Galactomannan, Glucomannan, Guagum, Locastgum
and Plutonic. The Electrolyte gel polymers are Polysaccharide
Polymers which are Aga, Algin, Carrageenan, Xantan and Gelan),
Functional Additive 1-10 wt %(extracted from group of Chitosan
derivative, Proteoglyucans, Elastin, Collagen and Hyaluronic
acid.
[0040] Based on total weight, the Branched gel polymers have 1-10
wt % and the Electrolyte gel polymers have 0.5-5 wt %. If the
composition is not within this range, gel state will not form nor
will it change to liquid state even with increase in
temperature.
[0041] Below stated skin-friendly enhancer will improve the
acceptability of the skin to help the drugs to rapidly penetrate
into skin, these substance are but not limited to the
Polysaccharides like Chitosan, Proteoglycans, Chitosan derivative,
Elastin, Collagen, Hyaluronic Acid or other Proteins that can be
water soluble. The desired quantity of 0.5-5 wt % is based on the
total weight of the composition. These skin-friendly enhancers are
less effective if the substances contained less than desirable
amount, and also there will be a problem of stationary state as a
gel if the substances contained more than the desirable amount.
[0042] Like the skin-friendly enhancers, below natural biomaterials
are also added to improve the acceptability of the skin. They are
natural substances that are extracted from plant, animal or mineral
which are as follows but not limited to extracted substance from
aloe, green tea, ginseng, wood vinegar, pine needles, propolis,
gingko leaves, and mulberry leaves (silkworm). The desirable
quantities are about 1-10 wt % based on total weight of the
composition. These natural biomaterials are less effective if the
substances contain less than desirable amount, but also there will
be a problem of stationary state as a gel if the substances contain
more than desirable amount.
[0043] Aliphatic Polyols like Propylene glycol and glycerine are
soluble in water liquid which facilitates hydrogel composition to
adhere and penetrate into the skin. The desirable quantities are
about 3-30 wt % based on total weight. If the alcohol content is
more than the desirable amount, formation of the gel state will be
a problem. If it is less than the desirable amount, then the
problem of stationary state as a gel will arise.
[0044] Functional additives listed below are the additives that can
provide stability and functionality. They are propilparavin, Kojic
acid, .alpha.-Hydroxy acid, imidazolidinylurea, twin80 and retinol.
Desirable quantities are 1-10 wt % based on total weight of the
composition. If the additive content are less than the desirable
amount, stability will be decreased which would prohibit from
long-term storage, and if it has more than the desirable amount,
the problem of stationary state as a gel will arise.
[0045] Water is the main substance of the hydrogel composition that
is based on total weight of the composition its quantity is about
30-93 wt %. Water content less than the amount will rose a problem
of stationary state when the temperature rises, and more water will
have a problem of not forming a gel.
[0046] Hydrogel composition comprised as above will have unique
characteristics of staying in a gel state in temperature between
0-10.degree. C., and changing to liquid state in 10-50.degree. C.
Also this invented hydrogel composition can remain as a gel state
at 0-30.degree. C. or at room temperature, and transform to liquid
state in 20-40.degree. C. depending upon different amount of
substances in the composition. As it was stated above, this
invented hydrogel composition is sensitive to temperature
difference and has characteristic of changing its states so that
skin care substances in the hydrogel composition can rapidly and
evenly penetrate into skin when it is applied directly to the
skin.
[0047] The Hydrogel composition can be produced by the following
method. First, mix Branched gel polymer and electrolyte gel polymer
into the Aliphatic Polyol and make the polymer solution, then mix
the functional additive to the Aliphatic Polyol and make the
functional solution. Combine the two polymer solution and the
functional solution and produce the basic mixture solution.
[0048] Next step is to mix the basic mixture solution with the
deionized water and heat the solution temperature to 45-95.degree.
C. While maintaining the temperature, add the acceptance enhancer
and the natural biomaterials to the solution which will produce the
liquid state Hydrogel composition. The amount of added substance
should be as mentioned before, and their benefits have also been
mentioned earlier.
[0049] Also, this invented hydrogel composition can be produced as
a patch or sheet to be applied to skin. For example, to apply this
invented hydrogel composition as a beauty care product, gel type
hydrogel can be produced by cooling liquid hydrogel composition
made in sheet or patch form to a temperature in between
45-95.degree. C. FIG. 3 shows the beauty care hydrogel sheet by
inserting rayon textile as a wick into hydrogel composition. Part
(a) is the rayon textile and part (b) is the invented hydrogel
composition.
[0050] When this invented hydrogel sheet or patch is applied to the
skin, the hydrogel will transform its state from gel to liquid by
the body temperature which will add the flux to the hydrogel.
Because this invented state-changing hydrogel changes to the liquid
state by the body temperature when it is applied to the skin, this
will let the hydrogel automatically adhere to the skin and the skin
will accept more of the substance. Therefore, it is more effective
in skin care than traditional hydrogel.
[0051] Below examples explains this invention in more detail.
However, this does not limit the inventions categories.
EXAMPLES
Example 1
[0052] Mix glycerine 170 g, Carrageenan 6 g and Locastgum 20 g at
room temperature and stir in a 3 liter heatable container. Add to
the mixture solution glycerine 30 g, metilparaben 0.8 g,
propileparaben 0.3 g. Add 740 g of deionized water and heat the
solution to 85.degree. C. This will be the gel solution.
[0053] While maintaining the temperature at 85.degree. C., add
sequentially aloe extraction 20 g, collagen 5 g, imidazolidinylurea
2 g, twin80 1.5 g, and chitosan 3.7 g to the gel solution. This is
the hydrogel composition. FIG. 1 shows the viscosity of the above
hydrogel composition measured at various temperatures. As it is
shown in FIG. 1, the hydrogel composition decreases its viscosity
when the temperature increases and transforms to liquid state.
[0054] Hydrogel sheet can be produced by adding a rayon textile as
a wick to this hydrogel composition at the temperature of
80.degree. C. and then cooling it. This will be used to release
beauty care ingredients to the skin.
[0055] Generally, when hydrogel is applied to skin the coverage is
40-70%. However, due to the characteristic of the invented hydrogel
which is temperature sensitive state-changing, it has 100% coverage
and faster migration rate of ingredient. It is a product that
increases epidermal absorption of hydrogel.
[0056] In the case of this invention, it is considered that
additional explanation about epidermal absorption is needed when
the hydrogel is applied to skin. However, please note that in a
case when sufficient time is necessary for the concrete experiment
and data entry, application should be submitted as it is. Then it
could be reapplied within a year with domestic priority
assertion.
Invention Effectiveness
[0057] The invented hydrogel composition is not only very effective
in skin care but also effective in skin treatment if rapid delivery
of drug or skin-friendly material is required. Especially, the
invented hydrogel can be used very effectively in skin care
transdermal cosmetic delivery.
* * * * *