U.S. patent application number 10/915332 was filed with the patent office on 2005-01-20 for external skin care composition.
This patent application is currently assigned to KAO CORPORATION. Invention is credited to Hiro, Kimihiko, Ohashi, Yukihiro, Sano, Tomohiko, Takagi, Yutaka, Yamaki, Kazuhiro.
Application Number | 20050013790 10/915332 |
Document ID | / |
Family ID | 14980341 |
Filed Date | 2005-01-20 |
United States Patent
Application |
20050013790 |
Kind Code |
A1 |
Yamaki, Kazuhiro ; et
al. |
January 20, 2005 |
External skin care composition
Abstract
The invention relates to an external skin care composition
comprising a ceramide production-accelerating agent and a
film-forming polymer. The external skin care composition can
enhance the barrier function of the skin and has an excellent skin
roughness-improving effect.
Inventors: |
Yamaki, Kazuhiro;
(Sumida-ku, JP) ; Sano, Tomohiko; (Sumida-ku,
JP) ; Hiro, Kimihiko; (Haga-gun, JP) ; Takagi,
Yutaka; (Haga-gun, JP) ; Ohashi, Yukihiro;
(Sumida-ku, JP) |
Correspondence
Address: |
OBLON, SPIVAK, MCCLELLAND, MAIER & NEUSTADT, P.C.
1940 DUKE STREET
ALEXANDRIA
VA
22314
US
|
Assignee: |
KAO CORPORATION
Tokyo
JP
|
Family ID: |
14980341 |
Appl. No.: |
10/915332 |
Filed: |
August 11, 2004 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
|
|
10915332 |
Aug 11, 2004 |
|
|
|
09564549 |
May 4, 2000 |
|
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Current U.S.
Class: |
424/74 |
Current CPC
Class: |
A61K 8/894 20130101;
A61Q 1/02 20130101; A61K 8/8176 20130101; A61K 8/891 20130101; A61Q
3/02 20130101; A61K 8/585 20130101; A61K 8/73 20130101; A61K 8/86
20130101; A61Q 17/00 20130101; A61Q 1/08 20130101; A61K 8/8152
20130101; A61Q 1/12 20130101; A61K 8/9794 20170801; A61Q 1/06
20130101; A61Q 1/10 20130101; A61Q 19/00 20130101; A61K 8/9789
20170801; A61Q 19/10 20130101; A61Q 17/04 20130101; A61K 8/675
20130101 |
Class at
Publication: |
424/074 |
International
Class: |
A61K 007/06 |
Foreign Application Data
Date |
Code |
Application Number |
May 10, 1999 |
JP |
11-128255 |
Claims
1. An external skin care composition comprising a ceramide
production-accelerating agent and a film forming polymer, wherein
the ceramide production-accelerating agent is (i) at least one
plant selected from the group consisting of eucalyptus, hop,
zingiber, Uncaria gambir Roxburgh, Rosa multiflora Thunberg, lily,
Job's tears, cattail, loquat, cape jasmine, Saponaria officinalis
Linne, white birch, hydrangea, clove, safflower, Sanguisorba
officinalis Linne, and Sophora flavescens Aiton, or an extract,
steam distilled product or pressed product of said plant: (ii) at
least one member selected from the group consisting of nicametate
citrate, quinolinic acid, pyridine-3,5-dicarboxylic acid,
nicotinamide adenine dinucleotide phosphate, nicotinic acid
mononucleotide, nicotinyl alcohol and tartaric acid nicotinyl
alcohol; or a mixture of (i) and (ii).
2-3. (Cancelled)
4. The external skin care composition according to claim 1, wherein
the film-forming polymer is at least one member selected from the
group consisting of natural polymers, acrylic resins, silicones,
celluloses, alkyd resins, carboxyvinyl polymers, olefin-maleic
anhydride copolymers and salts thereof, epoxy resins, polymers and
copolymers of vinylpyrrolidone, amphoteric polymers, and synthetic
polyelectrolytes.
5. The external skin care composition according to claim 1, wherein
the film-forming polymer is at least one member selected from the
group consisting of mucopolysaccharides, silicones, ionic
group-containing polymers, polyvinyl alcohol, polyvinyl
pyrrolidone, polyethylene glycol, polyacrylamide and alkyl acrylate
copolymers.
6. The external skin care composition of claim 1, wherein said
ceramide production-accelerating agent is present in an amount of
0.00001 to 20% by weight.
7. The external skin care composition of claim 1, wherein said
ceramide-production accelerating agent is present in an amount of
0.001 to 10% by weight.
8. The external skin care composition of claim 4, wherein the
film-forming polymer is at least one natural polymer selected from
the group consisting of proteins, collagen, chitin, chitosan, gum
arabic, guar gum, locust bean gum, xantham gum, acid
hetero-polysaccharides prepared from the callus of plants of the
genus Polanthes L., carrageenan, pullalan, pectin, dextrin, quince
(Cydonia oblongata), agar, hyaluronic acid, chondroitin sulfate,
methyl polyglutamate, ethyl polyglutamate, sodium alginate,
potassium alginate, and propylene glycol alginate.
9. The external skin care composition of claim 4, wherein the
film-forming polymer is at least one acrylic resin selected from
the group consisting of polyacrylic acid, poly(methyl acrylate),
poly(ethyl acrylate), poly(butyl acrylate), polyacrylamide,
poly(N-isopropylacrylamide), ammonium polyacrylate, sodium
polyacrylate, crosslinked sodium polyacrylate, poly methacrylic
acid, poly(methyl methacrylate), poly(ethyl methacrylate),
poly(butyl methacrylate), polymethacrylamide, sodium methacrylate,
acrylic acid-styrene-ammonium methacrylate copolmyers, acrylic
acid-styrene copolymers, acrylic acid-methacrylamide copolymers,
alkyl acrylate-styrene copolymers, alkyl acrylate-styrene
copolymers, alkyl acrylate copolymers, ethyl
acrylate-acrylamide-acrylic acid copolymers, ethyl acrylate-butyl
acrylate copolymers, ethyl acrylate-ethyl methacrylate copolymers,
ethyl acrylate-butyl acrylate copolymers, ethyl acrylate-ethyl
methacrylate copolymers, ethyl acrylate-methyl methacrylate-acrylic
acid copolymers, ethyl acrylate-methyl methacrylate copolymers,
ethyl acrylate-methacrylic acid copolymers, octyl acrylate-styrene
copolymers, octyl acrylate-vinyl acetate copolymers, hydroxypropyl
acrylate-butylaminoethyl methacrylate-acrylic acid acrylamide
copolymers, butyl acrylate-ethyl hydroxymethacrylate copolymers,
butyl acrylate-hydroxymethacrylic acid copolymers, butyl
acrylate-methacrylic acid copolymers, butyl acrylate-vinyl acetate
copolymers, methyl acrylate-ethyl acrylate copolymers, methyl
acrylate-styrene copolymers, methoxyethyl acrylate-hydroxyethyl
acrylate-butyl acrylate copolymers, methoxyethyl
acrylate-hydroxyethyl acrylate copolymers, acrylic resin
alkanolamines, methacrylic acid-styrene copolymers, methacrylic
acid-butyl methacrylate copolymers, methacrylic acid-methyl
methacrylate copolymers, and methyl methacrylate-butyl
acrylate-octyl acrylate copolymers.
10. The external skin care composition of claim 4, wherein the
film-forming polymer is at least one silicone selected from the
group consisting of alkyl-modified silicones, oxazoline-modified
silicones, dimethylsiloxane-methylcetyloxysiloxane copolymers, and
high molecular weight polysiloxanes.
11. The external skin care composition of claim 4, wherein the
film-forming polymer is at least one cellulose selected from the
group consisting of methyl cellulose, ethyl cellulose, cationized
cellulose, carboxymethyl cellulose, hydroxyethyl cellulose,
hydroxypropyl cellulose, and hydroxypropylmethyl cellulose.
12. The external skin care composition of claim 4, wherein the
film-forming polymer is at least one alkyd resin selected from the
group consisting of alkyd resins of isophthalic acid,
epoxy-modified alkyd resins of phthalic acid, alkyd resins of
succinic acid, alkyd resins comprising cyclohexane groups, alkyd
resins comprising cyclohexene groups, alkyd resins of phthalic
acid, and rosin-modified alkyd resins of maleic acid.
13. The external skin care composition of claim 4, wherein the
film-forming polymer is at least one carboxyvinyl polymer selected
from the group consisting of carboxyvinyl polymers, alkyl-modified
carboxyvinyl polymers, and calcium or potassium salts thereof.
14. The external skin care composition of claim 4, wherein the
film-forming polymer is at least one olefin-maleic anhydride
copolymers or salt thereof selected from the group consisting of
ethylene-maleic anhydride copolymers and isobutylene-sodium maleic
anhydride copolymers.
15. The external skin care composition of claim 4, wherein the
film-forming polymer is at least one epoxy resin selected from the
group consisting of bisphenol A epoxy resin stearic acid esters,
epoxy bisphenol A epoxy resin ricinoleic acid esters, epoxy resin
beef tallow fatty acid esters, and epoxy resin whale oil fatty acid
esters.
16. The external skin care composition of claim 4, wherein the
film-forming polymer is at least one vinylpyrrolidone polymer
selected from the group consisting of poly(vinyl pyrrolidone),
vinylpyrrolidone-styrene copolymers, vinylpyrrolidone-vinyl acetate
copolymers, and diethyl sulfate
vinylpyrrolidone-N,N-dimethylaminoethyl-m- ethacrylic acid
copolymers.
17. The external skin care composition of claim 4, wherein the
film-forming polymer is a
N-methacryloylethyl-N,N-dimethylammonium-N-meth-
yl-carboxybetaine-butyl methacrylate copolymer.
18. The external skin care composition of claim 4, wherein the
film-forming polymer is poly(methacryloyloxyethyltrimethylammonium
chloride).
19. The external skin care composition of claim 4, wherein the
film-forming polymer is present in an amount of 0.001 to 60% by
weight.
20. The external skin care composition of claim 4, wherein the
film-forming polymer is present in an amount of 0.005 to 40% by
weight.
21. The external skin care composition of claim 1, wherein the
composition further comprises at least one surfactant, oil, sterol,
amino acid, moisturizer, powder, ultraviolet absorbent, gelling
agent, antiinflammatory agent, antioxidant, and pH adjuster.
22. A cosmetic comprising the composition of claim 1.
23. The cosmetic of claim 22, wherein said cosmetic is selected
from the group consisting of a foundation, a powder, a lip stick, a
cheek rouge, an eye shadow, a nail enamel, and a bath additive.
24. The external skin care composition of claim 1, wherein the
composition has apH of 2 to 11.
25. The external skin care composition of claim 1, wherein the
composition has a pH of 3 to 9.
Description
BACKGROUND OF THE INVENTION
[0001] 1. Field of the Invention
[0002] The present invention relates to an external skin care
composition which can enhance the moisturizing function and barrier
function of the skin and has an excellent skin roughness-improving
effect.
[0003] 2. Description of the Background Art
[0004] Ceramide which is one of sphingolipids is largely present in
the horny layer and is known to deeply participates in the
development of protecting function and barrier function of the skin
to have effects on the improvement of a rough skin and the
prevention of cutaneous aging. Therefore, it is attempted to apply
an external skin care composition with natural ceramide or
pseudoceramide incorporated therein to the skin so as to supply
decreased ceramide in the horny layer. According to this attempt,
however, no long-term effect is recognized, and stability is
insufficient. On the other hand, substances capable of facilitating
the synthesis of ceramide in epidermic cells have been found, and
it has also been conducted to develop preparations for effectively
increasing the amount of ceramide in the horny layer. However,
their effects to improve a rough skin have been yet
insufficient.
SUMMARY OF THE INVENTION
[0005] It is an object of the present invention to provide an
external skin care composition which can enhance the barrier
function of the skin and has an excellent skin roughness-improving
effect.
[0006] The present inventors have found that when a ceramide
production-accelerating substance and a high-molecular compound
having film-forming properties are used in combination, an
excellent skin roughness-improving effect is synergistically
exhibited.
[0007] According to the present invention, there is thus provided
an external skin care composition comprising a ceramide
production-accelerating agent and a film-forming polymer.
[0008] The external skin care composition according to the present
invention can enhance the barrier function of the skin and has a
marked skin roughness-improving effect.
BRIEF DESCRIPTION OF THE DRAWINGS
[0009] The above and other objects, features and advantages of the
present invention will become apparent from the following
description and the appended claims, taken in conjunction with the
accompanying drawings, in which:
[0010] FIG. 1 diagrammatically illustrates the ceramide
production-accelerating effects of extracts of eucalyptus
(Eucalyptus globulus), hop and ginger (zingiber) on human
keratinocytes;
[0011] FIG. 2 diagrammatically illustrates the effects of
increasing the amount of ceramide in the epidermis and horny layer
by the extracts of eucalyptus (Eucalyptus globulus), hop and ginger
(zingiber); and
[0012] FIG. 3 diagrammatically illustrates the ceramide
production-accelerating effects of extracts of gambier (Uncaria
gambir Roxburgh), rose fruit (Rosa multiflora Thunberg), marronnier
(horse chestnut), lily, Coicis semen (Job's-tears), cattail (Typha
angustifolia linne), loquat, cape jasmine, ginseng (Panax ginseng
C. A. Meyer), Saponaria officinalis Linne, white birch (Betula
pendula Roth), hydrangea, clove, safflower, Sanguisorba officinalis
Linne, iris (Iris florentina L.) and Sophora flavescens Aiton on
human keratinocytes.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
[0013] No particular limitation is imposed on the ceramide
production-accelerating substance useful in the practice of the
present invention so far as it is a substance capable of
accelerating the production of ceramide in the skin. Examples
thereof include (1) plants, and extracts, steam distilled products
and pressed products thereof, and (2) nicotinic acid, nicotinic
acid salts, nicotinyl alcohol and derivatives thereof.
[0014] Examples of the plants in the item (1) include eucalyptus,
hop, zingiber, Uncaria gambir Roxburgh, Rosa multiflora Thunberg,
horse chestnut, lily, Job's-tears, cattail, loquat, cape jasmine,
Panax ginseng C. A. Meyer, Saponaria officinalis Linne, white
birch, hydrangea, clove, safflower, Sanguisorba officinalis Linne,
iris and Sophora flavescens Aiton.
[0015] Eucalyptus is a plant of Eucalyptus globulus or any other
related species thereof, belonging to the family Myrtaceas, and its
leaves, twigs, blossoms or fruits are mainly used.
[0016] Hop (Humulus lupulus) is a plant belonging to the family
Moraceae, and its female flower spikes are mainly used.
[0017] Zingiber (Zingiberis rhizoma) is a plant belonging to the
family Zingiberaceae, and its rhizome (ginger) is mainly used.
[0018] Uncaria gambir Roxburgh is a plant belonging to the family
Rubiaseae, and its leaves or young branches are mainly used.
[0019] Rosa multiflora Thunberg is a plant belonging to the family
Rosaceae, and its false fruits or fruits (nuts) (i.e., rose fruit)
are mainly used.
[0020] Horse chestnut (Aesculus hippocastanum Linne) is a plant
belonging to the family Hippocastanaceae, and its seeds, leaves or
bark is mainly used.
[0021] Lily (Lilium candidum) is a plant belonging to the family
Liliaceae, and its bulb is mainly used.
[0022] Job's-tears (Coix lacryma-jobi Linne var. ma-yuen Stapf) is
a plant belonging to the family Gramineae, and its seeds (Coicis
semen) from which a seed coat has been removed are mainly used.
[0023] Cattail is a plant of Typha angustifolia linne or any other
related species thereof, belonging to the family Typhaceae, and its
flower spikes are mainly used
[0024] Loquat (Eriobotrya japonica Lindley) is a plant belonging to
the family Rosaceae, and its leaves are mainly used.
[0025] Cape jasmine (Gardenia jasminoides Ellis) is a plant
belonging to the family Rubiaseae, and its fruits are mainly
used.
[0026] Panax ginseng C. A. Meyer (Panax schinseng Nees) is a plant
belonging to the family Araliaceae, and its root or a steamed and
dried product thereof is mainly used.
[0027] Saponaria officinalis Linne is a plant belonging to the
family Caryophyllaceae, and its leaves or root is mainly used.
[0028] White birch is a plant of Betula pendula Roth or any other
related species thereof, belonging to the family Betulaceae, and
its leaves, bark, xylem or sap is mainly used.
[0029] Hydrangea (Hydrangea serrata Seringe var. thunbergii
Sugimoto; Hydrangea macrophylla Seringe var. thunbergii Makino) is
a plant belonging to the family Saxifragaceae, and its leaves or
the tips of branches thereof are mainly used.
[0030] Clove (Syzygium aromaticum Merrill et Perry; Eugenia
caryophyllata Thunberg) is a plant belonging to the family
Myrtaceae, and its spikes (ears), flower stalks, immature fruits or
leaves are mainly used.
[0031] Safflower (Carthamus tinctorius Linne) is a plant belonging
to the family Compositae, and its flower, a portion obtained by
removing most of a yellow pigment from the flower, or the whole
thereof is mainly used.
[0032] Sanguisorba officinalis Linne is a plant belonging to the
family Rosaceae, and its root or rhizome is mainly used.
[0033] Iris is a plant belonging to the family Iridaceae,
exemplified by Iris florentina L., Iris germania L., Iris pallida
L., etc., and its rhizome is mainly used.
[0034] Sophora flavescens Aiton is a plant belonging to the family
Leguminosae, and its root or a portion obtained by removing most of
the periderm of the root is mainly used.
[0035] In the present invention, the above-described plants may be
used as they are, or after they are dried and ground. However,
extracts, steam distilled products or pressed products thereof may
also be used. More purified products thereof, such as essential
oils, may also be used, or commercial products may also be
utilized.
[0036] Examples of a solvent used in extraction include those
routinely used in extraction of plant components, such as water,
petroleum ether, n-hexane, toluene, dichloroethane, chloroform,
ether, ethyl acetate, acetone, methanol, ethanol, propanol,
butanol, ethylene glycol, propylene glycol and butylene glycol. Of
these, water, ethanol, propylene glycol and butylene glycol are
particularly preferred. These solvents may be used either singly or
in any combination thereof. Ordinary conditions may be applied for
the extraction. For example, any one of the above-described plants
is immersed at 3 to 100.degree. C. for several hours to several
weeks in the solvent or heated under reflux. When the plant is used
as an essential oil, the conventional method may also be adopted.
For example, the essential oil may be obtained from any one of the
above-described plants by steam distillation, extraction or
pressing. The extracts, steam distilled products or pressed
products of these plants may be used as ceramide
production-accelerating agents in the present invention as they
are. However, a fraction with high activity may also be
fractionated by a proper isolating means, for example, gel
filtration, chromatography or rectification.
[0037] Examples of nicotinic acid (salts), nicotinyl alcohol and
derivatives thereof in the item (2) include niconitic acid, methyl
nicotinate, ethyl nicotinate, benzyl nicotinate, nicotinamide,
nicametate citrate, tocopherol nicotinate, quinolinic acid,
pyridine-3,5-dicarboxyli- c acid, nicotinamide adenine dinucleotide
phosphate (NADP), niconitic acid mononucleotide, nicotinyl alcohol
and tartaric acid nicotinyl alcohol. These compounds may be used in
any form of commercial products, synthetic products and extracts
from nature.
[0038] These ceramide production-accelerating agents may be used
either singly or in any combination thereof. Among the
above-mentioned ceramide production-accelerating agents, (1) the
plants, and extracts, steam distilled products and pressed products
thereof are preferred, with eucalyptus extract and ginger extract
being particularly preferred. The amount of these ceramide
production-accelerating agents to be incorporated into the external
skin care composition according to the present invention is
preferably 0.00001 to 20% by weight, particularly 0.001 to 10% by
weight in terms of solid content. In the case of a bath additive
composition, such an amount is preferably used in an amount of at
least 0.1 ppb, particularly 1 to 1,000 ppb in a bath.
[0039] No particular limitation is imposed on the film-forming
polymer useful in the practice of the present invention. Specific
examples thereof include the following:
[0040] Natural Polymers:
[0041] proteins such as collagen, collagen derivatives and
decomposition products of keratin, chitin and derivatives thereof,
chitosan and derivatives thereof, gum arabic, guar gum, locust bean
gum, xanthan gum, acid hetero-polysaccharides derived from callus
of plants belonging to the genus Polyanthes L., carrageenan,
pullulan, pectin, dextrin, quince (Cydonia oblonga), agar,
hyaluronic acid, chondroitin sulfate, methyl polyglutamate, ethyl
polyglutamate, sodium alginate, potassium alginate, propylene
glycol alginate, etc.;
[0042] Acrylic Resins:
[0043] polyacrylic acid, poly(methyl acrylate), poly-(ethyl
acrylate), poly(butyl acrylate), polyacrylamide,
poly(N-isopropylacrylamide), ammonium polyacrylate, sodium
polyacrylate), crosslinked sodium polyacrylate, polymethacrylic
acid, poly(methyl methacrylate, poly-(ethyl methacrylate),
poly(butyl methacrylate), polymethacrylamide, sodium methacrylate,
acrylic acid-styrene-ammonium methacrylate copolymers, acrylic
acid-styrene copolymers, acrylic acid-methacrylamide copolymers,
alkyl acrylate-styrene copolymers, alkyl acrylate copolymers, ethyl
acrylate-acrylamide-acrylic acid copolymers, ethyl acrylate-butyl
acrylate copolymers, ethyl acrylate-ethyl methacrylate copolymers,
ethyl acrylate-methyl methacrylate-acrylic acid copolymers, ethyl
acrylate-methyl methacrylate copolymers, ethyl acrylate-methacrylic
acid copolymers, octyl acrylate-styrene copolymers, octyl
acrylate-vinyl acetate copolymers, hydroxypropyl
acrylate-butylaminoethyl methacrylate-acrylic acid acrylamide
copolymers, butyl acrylate-ethyl hydroxymethacrylate copolymers,
butyl acrylate-hydroxymethacrylic acid copolymers, butyl
acrylate-methyl methacrylate copolymers, butyl acrylate-methacrylic
acid copolymers, butyl acrylate-vinyl acetate copolymers, methyl
acrylate-ethyl acrylate copolymers, methyl acrylate-styrene
copolymers, methoxyethyl acrylate-hydroxyethyl acrylate-butyl
acrylate copolymers, methoxyethyl acrylate-hydroxyethyl acrylate
copolymers, acrylic resin alkanolamines, methacrylic acid-styrene
copolymers, methacrylic acid-butyl methacrylate copolymers,
methacrylic acid-methyl methacrylate copolymers, methyl
methacrylate-butyl acrylate-octyl acrylate copolymers, etc.;
[0044] Silicones:
[0045] alkyl-modified silicones, oxazoline-modified silicones,
dimethylsiloxane-methylcetyloxysiloxane copolymers, high-molecular
methyl polysiloxane, etc.;
[0046] Celluloses:
[0047] methyl cellulose, ethyl cellulose, cationized cellulose,
carboxymethyl cellulose, hydroxyethyl cellulose, hydroxypropyl
cellulose, hydroxypropylmethyl cellulose, etc.;
[0048] Alkyd Resins:
[0049] isophthalic acid type alkyd resins, epoxy-modified phthalic
acid type alkyd resins, succinic acid type alkyd resins,
cyclohexane type alkyd resins, cyclohexene type alkyd resins,
phthalic acid type alkyd resins, rosin-modified maleic acid type
alkyd resins, etc.;
[0050] Carboxyvinyl Polymers:
[0051] carboxyvinyl polymers, alkyl-modified carboxyvinyl polymers
and calcium or potassium salts thereof, etc.; Olefin-maleic
anhydride copolymers and salts thereof:
[0052] ethylene-maleic anhydride copolymers isobutylene-sodium
maleic anhydride copolymers, etc.;
[0053] Epoxy Resins:
[0054] bisphenol A type epoxy resin oleic acid esters, bisphenol A
type epoxy resin stearic acid esters, bisphenol A type epoxy resin
ricinoleic acid esters, epoxy resin beef tallow fatty acid esters,
epoxy resin whale oil fatty acid esters, etc.
[0055] Vinylpyrrolidone-Based Polymers:
[0056] poly(vinyl pyrrolidone), vinylpyrrolidone-styrene
copolymers, vinylpyrrolidone-vinyl acetate copolymers, diethyl
sulfate vinylpyrrolidone-N,N-dimethylaminoethyl-methacrylic acid
copolymers, etc.;
[0057] Amphoteric Polymers:
[0058]
N-methacryloylethyl-N,N-dimethylammonium-.alpha.-N-methylcarboxybet-
aine-stearyl methacrylate copolymers,
N-methacryloylethyl-N,N-dimethylammo-
nium-.alpha.-N-methyl-carboxybetaine-butyl methacrylate copolymers,
etc.;
[0059] Synthetic Polyelectrolytes:
[0060] poly(methacryloyloxyethyltrimethylammonium chloride), etc.;
and
[0061] Other Polymers:
[0062] poly(vinyl methyl ether), vinyl methyl ether-ethyl maleate
copolymers, vinyl methyl ether-butyl maleate copolymers,
styrene-methylstyrene-indene copolymers, toluenesulfonamide resins,
polyamide epichlorohydrin, polyethylene-imine, polyethylene glycol,
polyethylene glycol-epichlorohydrin-coconut oil
alkylamine-dipropylenetri- amine condensates, polyvinyl acetal
diester aminoacetate, polyvinyl acetal diethylamino-acetate,
poly(dimethylmethylenepieridinium chloride), methoxyethylene-maleic
anhydride copolymers, dimethyldiallylammonium chloride-acrylamide
copolymers, hydrogenated styrene-methylstyrene-indene copolymers,
maleic anhydride-diisobutylene copolymer sodium salts, nylon 6,
nylon 6,6, polyethylene, polypropylene, polyisobutylene,
polyisoprene, polystyrene, polytetrafluoroethylene, polyvinyl
alcohol, polyvinyl butyrate, polyvinyl chloride, vinyl
acetate-crotonic acid copolymers, vinyl acetate-styrene copolymers,
butadiene-acrylonitrile copolymers, etc.
[0063] These polymers may be used either singly or in any
combination thereof.
[0064] Among the above-mentioned film-forming polymers,
mucopolysaccharides, silicones, ionic group-containing polymers,
polyvinyl alcohol, polyvinyl pyrrolidone, polyethylene glycol,
polyacrylamide and alkyl acrylate copolymers are preferred. As the
preferred mucopolysaccharides, silicones and ionic group-containing
polymer, examples are chitin and derivatives thereof, xanthan gum,
pullulan and acid hetero-polysaccharides derived from callus of
plants belonging to the genus Polyanthes L., and hyaluronic acid;
alkyl-modified silicones, oxazoline-modified silicones and
high-molecular methyl polysiloxane; and sodium alginate, potassium
alginate, polyacrylic acid, acrylic acid-styrene copolymers,
carboxyvinyl polymers, alkyl-modified carboxyvinyl polymers and
carboxymethyl cellulose.
[0065] The amount of these film-forming polymers to be incorporated
into the external skin care composition according to the present
invention is preferably 0.001 to 60% by weight, particularly 0.005
to 40% by weight from the viewpoints of the feeling of the
resulting external skin care composition upon use and
stability.
[0066] Various kinds of optional components commonly used may be
suitably incorporated in the external skin care compositions
according to the present invention. For example, surfactants, oils,
sterols, amino acids, moisturizers, powders, ultraviolet
absorbents, gelling agents, antiinflammatory agents, antioxidants,
pH adjusters and other components.
[0067] The external skin care composition according to the present
invention may be prepared in any form, such as a solubilization
system, emulsification system, powder-dispersed solubilization
system, powder-dispersed emulsification system or powder-dispersed
oil system, in accordance with a method known per se in the art,
and can be used for a make-up cosmetic such as a foundation,
powder, lip stick, cheek rouge, eye shadow or nail enamel; or a
bath additive composition in the form of tablets, capsules,
granules, powder or solution.
[0068] The pH of the external skin care composition according to
the present invention is preferably adjusted to 2 to 11,
particularly 3 to 9.
PREPARATION EXAMPLE 1
Preparation of Eucalyptus Extract
[0069] Leaves of Eucalyptus globulus Labillardiere were cut into
pieces, and a mixed solvent (20:80; 100 ml) of water and
1,3-butanediol was added to the cut pieces (10 g) to conduct
extraction at room temperature for 24 hours while sometimes
stirring the mixture. The resultant extract was then filtered, and
the filtrate was left at rest for 7 days at 5.degree. C. to age the
filtrate, and dregs and precipitate formed were separated by
filtration. Water (100 ml) was added to the resultant filtrate, and
the mixture was concentrated to about 70 ml at 40.degree. C. under
reduced pressure. After this process was repeated 3 times, water
and 1,3-butanediol were added in such a manner that the
concentration of 1,3-butanediol was adjusted to 80 v/v %, and the
whole solution amounted to 100 ml.
PREPARATION EXAMPLE 2
[0070] Plant extracts shown in Table 1 were prepared in accordance
with a method known per se in the art.
1TABLE 1 Plant extract Plant Extraction solvent Hop extract Female
spikes of Humulus 1,3-Butanediol lupulus Ginger extract Rhizome of
Zingiber Water:ethanol = 50:50 officinale Roscoe Gambier extract
Leaves or young branches of Water.fwdarw.water:ethanol = 50:50
Uncaria gambir Roxburgh Rose fruit extract Fruits of Rosa
multiflora Water:ethanol = 50:50 Thunberg Marronnier extract Seeds
of Aesculus Water:1,3-butanediol = 50:50 hippocastanum Linne Lily
extract Bulb of Lilium candidum) Water:1,3-butanediol = 50:50
Coicis semen extract Seeds of Coix lacryma-jobi
Water:1,3-butanediol = 50:50 Linne var. ma-yuen Stapf from which a
seed coat has been removed Cattail extract Flower spikes of Typha
Water:1,3-butanediol = 10:90 angustifolia linne Loquat leaf extract
Leaves of Eriobotrya Japonica Water:1,3-butanediol = 10:90 Lindley
Cape jasmine extract Fruits of Gardenia 1,3-Butanediol jasminoides
Ellis Ginseng extract Root of Panax ginseng C. A. Water:ethanol =
50:50 Meyer Saponaria officinalis Leaves of Saponaria
Water:1,3-butanediol = 50:50 Linne extract officinalis Linne White
birch extract Bark or xylem of Betula Water:ethanol = 50:50 pendula
Roth Hydrangea extract Leaves or branch tips of Water:ethanol =
50:50 Hydrangea serrata Seringe var. thunbergii Sugimoto Clove
extract Spikes (ears) of Syzygium Water:ethanol = 50:50 aromaticum
Merrill et Perry Safflower extract The whole Carthamus
Water:ethanol = 50:50 tinctorius Linne Sanguisorba Root or rhizome
or Water:ethanol = 50:50 officinalis Linne Sanguisorba officinalis
Linne extract Iris root extract Rhizome of Iris florentina L.
Ethanol Sophora flavescens Root of Sophora flavescans
Water:ethanol:1,3- Aiton extract Aiton butanediol = 50:30:20
TEST EXAMPLE 1
Test for Acceleration of Ceramide Production (Cell System)
[0071] <Method>
[0072] Human keratinocytes (HK-f; product of Kyokuto Seiyaku Kogyo
K.K.) were cultured for 24 hours at 37.degree. C. under 5% CO.sub.2
in a medium (GIBCO SFM/-BPE, EGF) containing [.sup.14C]-serine
(product of Daiichi Pure Chemicals Co., Ltd.) using a 6-well plate.
The crude drug extract of eucalyptus, hop or ginger obtained in
Preparation Example 1 or 2 was then added to the medium in a
proportion of 0.001% by weight or 0.01% by weight in terms of solid
content to conduct the culture for additional 24 hours. After the
medium was removed, and the wells were washed once with PBS, cells
were scraped with a cell scraper to collect them in a test tube.
After water (3.6 ml), chloroform (4 ml) and methanol (4 ml) were
added to the human keratinocytes in this test tube to mix them, a
chloroform layer was isolated and dried to solid. The lipid
extracted was developed to the top twice with a solvent 1
(chloroform:methanol:acetic acid=190:9:1) and to 3 cm from the
bottom with a solvent 2 (chloroform:methanol:acetone=76:20:4) on a
HPTLC plate [silica gel G60 (20.times.10 cm), Art. 5641; product of
Merck Co.]. The counts of ceramide and glycosylceramide on the TLC
plate were measured by means of an autoradiograph (BAS2000;
manufactured by Fuji Photo Film Co., Ltd.).
[0073] <Results>
[0074] The results obtained by calculating out an acceleration rate
of ceramide production with the acceleration rate of a control, to
which no crude drug extract was added, regarded as 1.0 are shown in
FIG. 1. As apparent from FIG. 1, all extracts of eucalyptus, hop
and ginger were observed having a ceramide production-accelerating
effect on human keratinocytes.
TEST EXAMPLE 2
Test for Acceleration of Ceramide Production (Animal System)
[0075] <Method>
[0076] The plant extract (0.1% by weight, 0.01% by weight or 0.001%
by weight in terms of solid content) of eucalyptus, hop or ginger
obtained in Preparation Example 1 or 2, which had been diluted with
a 7:3 mixed solvent of propylene glycol and ethanol, was applied to
the back of a hairless mouse SKHI for 2 weeks, and the skin was
then cut out of the back. The skin was subjected to a heat
treatment at 60.degree. C. for 60 seconds, thereby peeling the
epidermis from the skin. The epidermis was divided into halves, and
the horny layer was prepared from one of them using 0.5% trypsin.
After the epidermis and horny layer were lyophilized, and their
weights were measured, lipid extraction was conducted in accordance
with the Bligh/Dyer method (chloroform:methanol:water=4:4:3.6)- ,
and the extracts were subjected to HPTLC in the same manner as in
Test Example 1. After development, the plate was immersed in a
solution containing 8% by weight of phosphoric acid and 10% by
weight of copper sulfate to conduct printing at 160.degree. C. for
15 minutes, and ceramide was then determined by means of a
densitometer (Bio.cndot.Image; manufactured by Bio-Image Co.).
[0077] <Results>
[0078] The results obtained by calculating out a quantitative
proportion of ceramide with the amount of ceramide in a control, to
which no crude drug extract was added, regarded as 1.0 are shown in
FIG. 2. As apparent from FIG. 2, all extracts of eucalyptus, hop
and ginger were observed having an effect of increasing the amounts
of ceramide in the epidermis and horny layer.
TEST EXAMPLE 3
Test for Acceleration of Ceramide Production (Cell System)
[0079] <Method>
[0080] A test for acceleration of ceramide production was conducted
in the same manner as in Test Example 1 except that the extracts of
gambier, rose fruit, marronnier, lily, Coicis semen, cattail,
loquat, cape jasmine, ginseng, Saponaria officinalis Linne, white
birch, hydrangea, clove, safflower, Sanguisorba officinalis Linne,
iris root and Sophora flavescens Aiton obtained in Preparation
Example 2 were separately used.
[0081] <Results>
[0082] The results obtained by calculating out an acceleration rate
of ceramide production with the acceleration rate of a control, to
which no crude drug extract was added, regarded as 1.0 are shown in
FIG. 3. As apparent from FIG. 3, all the extracts were observed
having a ceramide production-accelerating effect on human
keratinocytes.
TEST EXAMPLE 4
EXAMPLES 1 TO 4 AND COMPARATIVE EXAMPLES 1 to 4
[0083] Emulsification type cosmetic compositions having their
corresponding formulations shown in Table 2 were prepared in a
method known per se in the art to evaluate them as to effects of
enhancing the moisturizing function and barrier function of the
skin and the improvement rate of skin roughness.
[0084] (Evaluation Method)
[0085] Chosen as volunteers in winter were 10 women of 20 to 40
years of old who had skin roughness on their both cheeks. Each of
the above-prepared external skin care preparations was applied to
the left and right cheeks of each volunteer 3 times a day. On the
following day of the completion of the 3-week application test,
evaluation was made with respect to the following items. The
results are shown in Table 2.
[0086] (1) Effect of Enhancing a Moisturizing Function:
[0087] After washing the face with warm water of 37.degree. C.,
each volunteer was allowed to rest for 30 minutes in a room which
was air-conditioned at 20.degree. and 40% humidity. The water
content of her horny layer was then measured by an impedance meter
(manufactured by IBS Company). The measured value was indicated by
an average value .+-.standard error. A higher measured value
indicates that the test sample has a higher effect for enhancing
the moisturizing function of the skin.
[0088] (2) Effect of Enhancing the Barrier Function of the
Skin:
[0089] A transepidermal water loss (TEWL) was measured by means of
a Hydrometer (manufactured by Meeco Co.) in accordance with a
method known per se in the art. A lower transepidermal water loss
indicates that the test sample has a higher effect for enhancing
the water-retaining function and barrier function of the skin.
[0090] (3) Improvement Rate of Skin Roughness:
[0091] Skin roughness was observed visually and ranked in
accordance with the following standard. Each score was indicated by
an average value .+-. standard error. A lower score indicates a
higher improvement rate of skin roughness.
[0092] 0: No skin roughness was observed;
[0093] 1: Slight skin roughness was observed;
[0094] 2: Skin roughness was observed;
[0095] 3: Rather severe skin roughness was observed;
[0096] 4: Severe skin roughness was observed.
2 TABLE 2 Example Comparative Example 1 2 3 4 1 2 3 4 Eucalyptus
extract (in terms of 0.01 0.02 0.02 -- -- 0.01 -- -- solids) Ginger
extract (in terms of -- -- -- 0.02 -- -- -- -- solids) Pullulan 2.0
2.0 1.0 -- -- 2.0 2.0 Polyethylene glycol*.sup.1 -- -- 1.0 -- -- --
-- -- Alkyl acrylate copolymer*.sup.2 -- -- -- 1.0 -- -- -- --
Polyvinyl pyrrolidone*.sup.3 -- -- -- 1.2 -- -- -- -- Cholesterol
-- -- -- -- -- -- -- 0.5 Hydrogenated, purified soybean -- -- -- --
-- -- -- 1.0 lecithin Sorbitan monostearate 2.0 2.0 2.0 2.0 2.0 2.0
2.0 2.0 2-Octyldodecyl myristate 10.0 10.0 10.0 10.0 10.0 10.0 10.0
10.0 Squalane 5.0 5.0 5.0 5.0 5.0 5.0 5.0 5.0 succinic acid 1.0 1.0
1.0 1.0 1.0 1.0 1.0 1.0 Potassium succinate trihydrate 1.0 1.0 1.0
1.0 1.0 1.0 1.0 1.0 Purified water Bal. Bal. Bal. Bal. Bal. Bal.
Bal. Bal. Water content in the horny layer 25.5 .+-. 3.3 27.0 .+-.
2.9 23.6 .+-. 2.6 27.5 .+-. 2.5 7.2 .+-. 1.0 8.5 .+-. 0.6 9.0 .+-.
1.0 9.5 .+-. 1.0 (.mu.moh) Transepidermal water loss 7 5 5 4 25 22
20 21 (g/m.sup.2 .multidot. hr) Score of skin roughness 0.9 .+-.
0.3 0.9 .+-. 0.2 0.8 .+-. 0.2 0.7 .+-. 0.2 3.0 .+-. 0.4 2.8 .+-.
0.8 2.4 .+-. 0.3 2.4 .+-. 0.3 *.sup.1PEG-1540, product of Sanyo
Chemical Industries, Ltd. *.sup.2Iodosol GH810, product of Kanebo
NSC Ltd. *.sup.3Rubisquall K-90, product of BASF Japan Ltd.
TEST EXAMPLE 5
[0097] Emulsification type cosmetic compositions were prepared in
the same manner as in Test Example 4 except that extracts of hop,
gambier, rose fruit, marronnier, lily, Coicis semen, cattail,
loquat leaf, cape jasmine, ginseng, Saponaria officinalis Linne,
white birch, hydrangea, clove, safflower, Sanguisorba officinalis
Linne, iris root and Sophora flavescens Aiton set forth in Table 1
were separately incorporated in place of the eucalyptus extract in
the formulation of Test Example 4 shown in Table 2, and evaluated
as to effects of enhancing the moisturizing function and barrier
function of the skin and the improvement rate of skin roughness in
the same manner as in Test Example 4. As a result, all the
emulsification type cosmetic compositions were found to have
excellent effects.
EXAMPLE 5
Toilet Lotion
[0098] A toilet lotion having the following composition was
prepared in accordance with a method known per se in the art.
3 (wt. %) Eucalyptus extract (in terms of solids) 0.01 Polyethylene
glycol*.sup.1 1.00 Polyoxyethylene (29) sorbitan monolaurate 1.50
Glycerol 2.00 Paraben 0.10 Purified water Balance *.sup.1PEG-1540,
product of Sanyo Chemical Industries, Ltd.
EXAMPLE 6
O/W Type Emulsion
[0099] An O/W type emulsion having the following composition was
prepared in accordance with a method known per se in the art.
4 (wt. %) Eucalyptus extract (in terms of solids) 0.02 Polyethylene
glycol*.sup.1 1.00 Pullulan*.sup.2 0.40 Cetyl alcohol 1.00 Vaseline
2.00 Squalane 6.00 Dimethyl polysiloxane 2.00 Glycerol 2.00
Pseudoceramide*.sup.3 1.00 Polyoxyethylene (10) monooleate 1.00
Glycerol monostearate 1.00 Acid hetero-polysaccharide derived from
2.00 callus of plant*.sup.4 Paraben 0.20 Purified water Balance
*.sup.1PEG-2000, product of Sanyo Chemical Industries, Ltd.
*.sup.2Pullulan PI-20, product of Hayashibara Company, Ltd.
*.sup.3N-(3-Hexadecyloxy-2-hydroxypropyl)-N-2-hydroxyethylhexadecanamide.
*.sup.41% by weight aqueous solution of tuberose
polysaccharide.
EXAMPLE 7
W/O Type Cream
[0100] A W/O type cream having the following composition was
prepared in accordance with a method known per se in the art.
5 (wt. %) Eucalyptus extract (in terms of solids) 0.02 Alkyl
acrylate copolymer*.sup.1 1.30 Polyvinyl pyrrolidone*.sup.2 0.70
Dimethyl polysiloxane 10.00 Methylphenyl polysiloxane 3.00
Octamethylcyclotetrasiloxane 12.00 Polyoxyalkylene-modified
silicone 5.00 1-3-Butylene glycol 6.00 Pseudoceramide*.sup.3 1.20
Paraben 0.20 Perfume base Trace amount Purified water Balance
*.sup.1Iodosol GH810, product of Kanebo NSC Ltd. *.sup.2Rubisquall
K-90, product of BASF Japan Ltd.
*.sup.3N-(3-Hexadecyloxy-2-hydroxypropyl)-N-2-hydroxyethylhexadecanamide.
EXAMPLE 8
Sunscreen Composition
[0101] A sunscreen composition having the following composition was
prepared in accordance with a method known per se in the art.
6 (wt. %) Ginger extract (in terms of solids) 0.01 Alkyl acrylate
copolymer*.sup.1 0.80 Polyethylene glycol*.sup.2 1.00 Octyl
p-methoxycinnamate 5.00 Silicon-coated zinc oxide 6.00
Silicon-coated titanium oxide 0.50 Dimethyl polysiloxane 5.00
Octamethylcyclotetrasilox- ane 20.00 Polyoxyalkylene-modified
silicone 3.00 Ethanol 3.00 Glycerol 3.00 Magnesium sulfate 1.00
Paraben 0.20 Perfume base Trace amount Purified water Balance
*.sup.1Iodosol GH810, product of Kanebo NSC Ltd. *.sup.2PEG-4000S,
product of Sanyo Chemical Industries, Ltd.
EXAMPLE 9
Cosmetic Jelly
[0102] A cosmetic jelly having the following composition was
prepared in accordance with a method known per se in the art.
7 (wt. %) Ginger extract (in terms of solids) 0.01 Polyethylene
glycol*.sup.2 0.50 Xanthan gum*.sup.2 0.20 Glycerol 3.00 Ethanol
3.00 Carboxyvinyl polymer 0.50 Potassium hydroxide 0.15
Polyoxyethylene hardened castor oil 1.00 Citric acid 0.80 Trisodium
citrate 0.80 Nylon powder 1.00 Paraben 0.10 Perfume base Trace
amount Purified water Balance *.sup.1PEG-2000, product of Sanyo
Chemical Industries, Ltd. *.sup.2Neosoft XKK, product of Kohjin
Co., Ltd.
EXAMPLE 10
Liquid Bath Additive Composition
[0103] A liquid bath additive composition having the following
composition was prepared in accordance with a method known per se
in the art.
8 (wt. %) Eucalyptus extract (in terms of solids) 0.02
Pseudoceramide*.sup.1 0.10 Isopropyl myristate 15.00 Liquid
paraffin Balance Polyoxyethylene (12) oleyl ether 10.00
Polyoxyethylene (6) oleyl ether 6.00 Acid hetero-polysaccharide
derived from 2.00 callus of plant*.sup.2 Paraben 0.30 Perfume base
Trace amount *.sup.1N-(3-Hexadecyloxy-2-hydroxypropyl)-N-2-hyd-
roxyethylhexadecanamide. *.sup.21% by weight aqueous solution of
tuberose polysaccharide.
[0104] The Japanese priority document JP11-128255 filed on May 10,
1999 is hereby incorporated, in its entirety, by reference.
* * * * *