U.S. patent application number 10/492199 was filed with the patent office on 2004-12-09 for tooth agent.
Invention is credited to Hosoya, Manabu, Kitsunai, Yoshitaka, Matsumoto, Hiromasa, Oshino, Kazushi.
Application Number | 20040247533 10/492199 |
Document ID | / |
Family ID | 26624092 |
Filed Date | 2004-12-09 |
United States Patent
Application |
20040247533 |
Kind Code |
A1 |
Hosoya, Manabu ; et
al. |
December 9, 2004 |
Tooth agent
Abstract
A toothpaste filled in a container which has two chambers and is
capable of simultaneously discharging two different compositions
filled respectively in the two chambers when the main body of the
container is pressed, wherein a ratio of a storage modulus G.sub.A'
of Composition (A) filled in one chamber to a storage modulus
G.sub.B' of Composition (B) filled in the other chamber falls
within a range of from 0.6 to 1.4. By controlling the ratio, it is
possible to stably discharge from the container storing these two
compositions separately predetermined amounts of these two
compositions which will otherwise cause a time-dependent change if
they are pre-mixed thereby failing to attain the purpose of their
addition.
Inventors: |
Hosoya, Manabu; (Tokyo,
JP) ; Oshino, Kazushi; (Tokyo, JP) ;
Matsumoto, Hiromasa; (Tokyo, JP) ; Kitsunai,
Yoshitaka; (Tokyo, JP) |
Correspondence
Address: |
OBLON, SPIVAK, MCCLELLAND, MAIER & NEUSTADT, P.C.
1940 DUKE STREET
ALEXANDRIA
VA
22314
US
|
Family ID: |
26624092 |
Appl. No.: |
10/492199 |
Filed: |
April 21, 2004 |
PCT Filed: |
October 25, 2002 |
PCT NO: |
PCT/JP02/11099 |
Current U.S.
Class: |
424/49 |
Current CPC
Class: |
A61K 2800/88 20130101;
A61K 8/19 20130101; A61K 8/0204 20130101; A61K 8/11 20130101; A61Q
11/00 20130101; A61K 8/21 20130101 |
Class at
Publication: |
424/049 |
International
Class: |
A61K 007/16 |
Foreign Application Data
Date |
Code |
Application Number |
Oct 25, 2001 |
JP |
2001-327367 |
Mar 11, 2002 |
JP |
2002-65550 |
Claims
1. A toothpaste having two compositions which are filled separately
in two chambers of a container capable of simultaneously
discharging therefrom these two compositions when the body of the
container is pressed, wherein a ratio of the storage modulus
G.sub.A' of one composition (A) in one chamber to the storage
modulus G.sub.B' of the other composition (B) in another chamber
falls within a range of from 0.6 to 1.4.
2. The toothpaste of claim 1, wherein the ratio G.sub.A'/G.sub.B'
is a ratio at tan.delta.=1.
3. The toothpaste of claim 1, wherein at least one of the
compositions contains at least one of sodium carboxymethylcellulose
and silica.
4. The toothpaste of any one of claims 1 to 3, wherein composition
(A) contains a calcium ion-supplying compound, while composition
(B) contains a fluoride ion-supplying compound.
5. The toothpaste of claim 4, wherein composition (A) contains
granules.
Description
TECHNICAL FIELD
[0001] The present invention relates to a toothpaste having two
different compositions which are filled separately in two chambers
of a container capable of simultaneously discharging therefrom
predetermined amounts of these two different compositions.
BACKGROUND ART
[0002] The dentin is composed mainly of hydroxyapatite (Ca.sub.10
(PO.sub.4) .sub.6 (OH).sub.2). In the mouth, there is an
equilibrium between dissolution (demineralization) of phosphate
ions and calcium ions and crystallization (remineralization) of
calcium phosphate or hydroxyapatite. At the initial stage of tooth
decay, white spots usually appear in the transparent enamel layer
of the tooth. If fluoride ions or calcium ions are caused to exist
on the tooth surface at this stage, remineralization is promoted by
these fluoride ions or calcium ions, resulting in the disappearance
of these white spots and recovery of transparency of the enamel
layer.
[0003] When both fluoride ions and calcium ions are incorporated in
one composition in advance, however, they react with each other to
form calcium fluoride particles having too large a particle size to
be taken readily into the tooth. This results in the problem that a
tooth remineralization-promotion effect is not possible.
[0004] To overcome this problem, a two-component type oral hygiene
product has been proposed (Japanese Patent Application Laid-Open
No. Sho 52-61236) in which two components are contained in
respective containers and, upon use, they are mixed as needed. The
toothpaste disclosed therein is however inconvenient, because the
two components filled separately in the respective tubes must be
mixed upon use.
[0005] Japanese Patent Application Laid-Open No. Sho 53-41441
discloses "a toothpaste composed of at least two components which
are mutually reactive and are maintained separately in one
dispensing container capable of discharging the content therefrom
via a closable orifice". Japanese Patent Application Laid-Open No.
Sho 58-219107 discloses a bottle having two compartments as an
embodiment physically separating a calcium ion substance and a
fluoride ion substance. Japanese Patent Application Laid-Open No.
2001-247439 discloses "a complex toothpaste comprising a first
toothpaste component containing tricalcium phosphate as a main
effective ingredient; a second toothpaste component containing a
fluoride compound as a main effective component; and an
integrally-formed container having a plurality of chambers needed
to hold these two components separatly and a discharge port
required for discharging these two components therefrom. In each of
the above-described documents, however, no reference is made to
discharging of a predetermined amount of each composition filled in
the chamber or compartment.
[0006] On the other hand, it is difficult to stably discharge the
desired amounts of the two compositions filled in the respective
chambers or compartments, because they have different components
and therefore have different physical properties. In some cases,
imbalance in the discharged amount between these two compositions
occurs and the amount of one of them is excessively large, while
that of the other one is small. It is therefore difficult to stably
discharge predetermined amounts of these two compositions every
time they are discharged. In particular, when one of the
compositions contains granules and the other one does not, the
above-described problem is pronounced owing to a difference in the
physical properties attributable to the presence or absence of the
granules, making it difficult to simultaneously and stably
discharge desired amounts of these two compositions whenever they
are discharged.
[0007] The present invention relates to a toothpaste containing two
compositions prepared separately in advance as respective
compositions and filled separately in a tube container capable of
discharging a mixture of the compositions each in a predetermined
amount, said two compositions, when mixed in advance, being not
able to achieve the intended object of the invention.
DISCLOSURE OF THE INVENTION
[0008] The present inventors have carried out an investigation on a
composition, paying attention to the viscoelastic behavior of the
composition. As a result, it has been found that squeezed amounts
of two different compositions which have been filled in the
respective chambers of a tube container can be controlled by
specifying a ratio of the storage modulus G'.sub.A of one
composition (A) filled in one chamber to the storage modulus
G'.sub.B of the other composition (B) filled in the other chamber,
particularly a ratio of the storage modulus (G'.sub.A/G'.sub.B) at
tan.delta.=1, leading to the completion of the present
invention.
[0009] In the present invention, there is thus provided a
toothpaste having two compositions filled separately in two
chambers of a container capable of simultaneously discharging
therefrom these two compositions when the body of the container is
pressed, wherein a ratio of the storage modulus G.sub.A' of one
composition (A) in one chamber to the storage modulus G'.sub.B of
the other composition (B) in another chamber falls within a range
of from 0.6 to 1.4, preferably a ratio G.sub.A'/G.sub.B' of the
storage modulus at tan.delta.=1 falls within a range of from 0.6/1
to 1/0.6.
BRIEF DESCRIPTION OF THE DRAWINGS
[0010] FIG. 1 illustrates transverse cross-sections (5 type) of
toothpaste containers.
IN A PREFERRED EMBODIMENT
[0011] In the present invention, the storage modulus G' is a value
(Pa) as measured by a rheometer ("MCR300", product of Paar Physica)
when 0.1 to 1000% strain is applied under the following conditions:
use of a 25 mm Parallel Plate, plate-plate distance of 0.7 mm,
frequency of 0.16 Hz, and measuring temperature of 25.degree. C.
The measuring method is not limited thereto, wherein a rheometer is
preferred, and various commercially available ones are usable.
[0012] The initial modulus G.sub.o'is determined by the following
measuring method. The composition is placed on the testing stand of
a rheometer and clamped with parallel plates to give a
predetermined thickness. After it is allowed to stand for 15
minutes to sufficiently relax the stress applied to the sample upon
clamping, measurement is started. The storage modulus G' and loss
modulus G" are measured while changing the intensity of the strain
in 20 steps from 0.1% to 1000% strain at an equal interval on a
common logarithm. The initial modulus G.sub.o' is the value at the
third step in 20 steps, that is, a storage modulus G' when 0.25%
strain is applied.
[0013] The initial modulus G.sub.o', storage modulus G' and storage
modulus G' at tan.delta.=1 can be adjusted to desired values by
controlling the content of each component in the composition. For
example, a composition having desired initial modulus G.sub.o'and
modulus G' at tan.delta.=1 can be obtained as shown below in Table
1 by using two kinds of silicas different in an oil absorption
amount and two kinds of sodium carboxymethylcelluloses different in
degree of etherification.
[0014] The term "tan.delta." as used herein means a ratio of the
storage modulus G' to the loss modulus G" (tan.delta.=G"/G'). The
storage modulus G' and loss modulus G" are parameters indicating
the dynamic viscoelasticity, details of which are described
specifically, for example, in "Oishisa no Rheology", Nobuko
Nakahama, Hiro Ogoshi, Hatsue Moritaka (Kougaku Shuppan),
p22-26".
[0015] The two kinds of silicas different in an oil absorption
amount and used for the adjustment of the modulus G' are, for
example, two kinds of silicas selected from those having an oil
absorption amount ranging from 50 to 400 mL/100 g. Examples of the
commercially available silicas different in an oil absorption
amount include "SORBOSIL" (product of CROSFIELD) and "SYLOPURE"
(product of Fuji Silysia Chemical Ltd).
[0016] The oil absorption amount can be measured by a method in
accordance with JIS K5101.
[0017] As the two kinds of sodium carboxymethylcelluloses different
in degree of etherification, two kinds of carboxymethylcelluloses
selected from carboxymethylcelluloses having a degree of
etherification ranging from 0.3 to 2.0 can be used. Specific
examples of the carboxymethylcelluloses different in degree of
etherification include "CMC Daicels" produced by Daicel Chemical
Industries.
[0018] The initial modulus G.sub.o' and the modulus G' at
tan.delta.=1 are adjusted by properly using them in combination.
Specifically, for example, the initial modulus G.sub.o' and the
modulus G' at tan.delta.=1 both increase by increasing the
incorporation ratio of a silica having a larger oil absorption
amount as shown later in Table 2. The initial modulus G.sub.o'
increases and the modulus G' at tan.delta.=1 lowers by increasing
the incorporation ratio of a carboxymethylcellulose having a lower
degree of etherification.
[0019] In the present invention, a ratio G.sub.A'/G.sub.B' of the
modulus of Composition (A) to that of Composition (B), in which
both of the compositions are filled in the respective chambers of
the container, is from 0.6 to 1.4, preferably from 0.8 to 1.25,
more preferably from 0.9 to 1.11, especially preferably 1
(G.sub.A'/G.sub.B'=1).
[0020] In order to constantly discharge the two compositions in
equal amounts, it is preferred to adjust the ratio of
G'.sub.A/G'.sub.B at tan.delta.=1 to fall within a range of from
0.6/1 to 1/0.6, preferably from 0.8/1 to 1/0.8, more preferably
from 0.9/1 to 1/0.9, especially preferably 1. In addition, it is
preferred to adjust the initial storage modulus G' of each of the
two compositions to fall within a range of from 200 to 2000 Pa.
[0021] In the two compositions of the toothpaste of the present
invention, that is, Composition (A) and Composition (B), two
components which will react with each other and undergo a
time-dependent change to fail to attain the purpose of the
invention are incorporated separately. For example, a calcium
ion-supplying compound is incorporated into Composition (A), while
a fluoride ion-supplying compound is incorporated into Composition
(B). Since these compounds are filled in separate chambers of a
container, they do not react with each other. When the container is
pressed, they are discharged simultaneously from separate chambers,
react with each other in an oral cavity, and form fine particles of
calcium fluoride in the vicinity of the tooth surface, thereby
bringing about excellent remineralization promoting effects of the
tooth.
[0022] Examples of the calcium ion-supplying compound contained in
Composition (A) include calcium lactate, calcium carbonate, calcium
secondary phosphate, calcium tertiary phosphate, calcium
pyrophosphate, and calcium sulfate. In Composition (A), not only
the calcium ion-supplying compound, but also a powdery component
such as water insoluble sodium metaphosphate, silica, aluminum
hydroxide, magnesium phosphate, zeolite, aluminosilicate composite,
magnesium carbonate or red iron oxide may be incorporated.
[0023] When the powdery component is added, the average particle
size of its primary particles is 0.1 to 10 .mu.m, preferably from
0.3 to 7 .mu.m, more preferably from 0.5 to 2 .mu.m. The term
"average particle size" as used herein means a value as measured by
a laser diffraction/scattering particle size distribution
analyzer.
[0024] The calcium ion-supplying compound is preferably
incorporated in Composition (A) in an amount of from 50 to 16000
ppm, more preferably from 200 to 8000 ppm, even more preferably
from 800 to 8000 ppm, each in terms of calcium ion.
[0025] Composition A preferably contains granules and their average
particle size is preferably from 50 to 500 .mu.m. The term "average
particle size" as used herein means a value as measured by a laser
diffraction/scattering particle size distribution analyzer, and
from the viewpoint of the feeling during teeth brushing, the
particle size from 90 to 400 .mu.m is especially preferred.
[0026] For these granules, water can be used as a binder, and
either an organic or inorganic binder can also be used. Examples of
the organic binder include water soluble polymers such as
polyacrylic acid, polyvinyl alcohol and polyethylene glycol,
polysaccharides such as hydroxyethylcellulose,
carboxymethylcellulose, hydroxypropylcellulose, xanthan gum and
carrageenan, water insoluble polymers such as natural fibers,
polyvinyl chloride, polyethylene, polypropylene, polystyrene,
poly(methyl methacrylate), nylon and silicone, and oils or fats
such as paraffin, higher alcohols and waxes. Examples of the
inorganic binders include water soluble metal salts such as sodium
chloride and potassium chloride, water soluble metal salts of an
organic acid such as sodium citrate, sodium tartrate and sodium
siccinate, and non-water-soluble compounds such as colloidal
silica, magnesium aluminometasilicate, bentonite, montmorillonite,
kaolin, synthetic aluminum silicate, calcium silicate, aluminum
hydroxide gel, alumina sol, magnesium carbonate, synthetic
hydrotalcite, magnesium oxide and magnesium hydroxide. These
binders may be used in combination of at least two of them. From
the viewpoint of the stability of granules in the toothpaste, the
inorganic non-water-soluble compounds are preferred as the binder,
with colloidal silica and synthetic aluminum silicate being
particularly preferred.
[0027] As the granules, those disintegrated under a load of from
0.1 to 50 g, preferably from 3 to 15 g per granule are preferred,
because they are excellent in plaque removing performance, and at
such disintegration strength, they are disintegrated moderately by
brushing without inducing a foreign-matter sensation in the oral
cavity.
[0028] Such granules are prepared by spray granulation, spray
cooling, extrusion, pressing, cutting or granulation method.
[0029] The toothpaste of the present invention preferably contains
1 to 50 mass %, more preferably from 3 to 40 mass %, even more
preferably from 5 to 30 mass % of granules in the whole
toothpaste.
[0030] As the fluoride ion-supplying compound contained in
Composition (B), either an inorganic compound or an organic
compound may be used. Specific examples include sodium fluoride,
potassium fluoride, tin fluoride, sodium fluosilicate, sodium
monofluorophosphate, aluminum fluoride, silver fluoride, hexylamine
hydrofluoride, decanolamine hydrofluoride, and octadecenylamine
hydrofluoride of these, use of sodium monofluorophosphate or sodium
fluoride is especially preferred. The content of the fluoride
ion-supplying compound in the total amount of the toothpaste of the
present invention is preferably from 0.002 to 1 mass %, especially
from 0.01 to 0.2 mass % in terms of fluorine.
[0031] Compositions (A) and (B) of the toothpaste of the present
invention may contain, in addition to the above-described
components, a humectant such as glycerin and polyethylene glycol,
an effervescent agent, a bond such as sodium carboxymethyl
cellulose, carrageenan and silica, a sweetener such as sodium
saccharin, a colorant, a preservative such as methyl
paraoxybenzoate, a bactericide such as benzethonium chloride,
isopropylmethylphenol and triclosan, an anti-inflammatory agent,
and a flavor.
[0032] The toothpaste of the present invention can be prepared by
adjusting the contents of the above-described components, and
filling Composition (A) and Composition (B), which have been
adjusted to have a ratio of the modulus G'.sub.A/ G'.sub.B within a
predetermined range, in respective chambers of a container capable
of discharging the content when a pressure is applied.
[0033] As the container, various containers capable of discharging
the content filled therein when the body of the container is
pressed can be used. It is preferable to use a container which has
been obtained by stacking thin metal films or thin plastic films to
form a tube, sealing one end of the tube, and providing, a
discharge port for simultaneously discharging plural contents at
the other end of the tube and, inside of the tube, a plurality of
compartments each connected with the discharge port and extending
from the one end of the tube to the other end of the tube. With
such a structure, it is possible to apply equal pressure to these
compartments whenever pressure is applied.
[0034] The compartments include those obtained by disposing a
barrier inside of the container to prevent mixing of the two
compositions, bag-like compartments, those obtained by inserting
smaller container(s) in the main container, and those obtained by
joining containers at the discharge port. Any of these compartments
has one end connected with the discharge port of the container. In
addition, it is preferred that a ratio of the cross-sectional areas
of the two compartments (R.sub.c) and a ratio of the volumes of the
two compartments (R.sub.v) are approximately equal, specifically,
R.sub.c/R.sub.v is within a range of from 0.9/1 to 1/0.9.
[0035] FIG. 1 illustrates examples of the cross-sections of the
containers having compartments therein. They are: a container
divided into two compartments disposed inside thereof (FIG. 1 (1)),
that having two cylindrical compartments disposed concentrically
(FIG. 1 (2)), that having two cylindrical compartments disposed
eccentrically (FIG. 1 (3)), that having one semi-columnar
compartment disposed therein (FIG. 1 (4)), and that having two
semi-columnar compartments disposed therein (FIG. 1 (5)).
EXAMPLES
Examples 1 and 2
[0036] Compositions of A group and B group shown in Tables 1 and 2
were prepared. Composition A and Composition B were filled
respectively in two 60-mL compartments of a toothpaste container
having the cross-section shown in FIG. 1 (5).
[0037] Test on discharge property:
[0038] The bottom (sealed portion) of the container was inserted
lightly into a tube compressor having two rubber rolls which had a
diameter of 5 cm and were arranged with a clearance of 0.5 mm, and
stress was applied to the tube by rotating the rolls. The container
was pressed so that the toothpaste 1 cm in length was squeezed out
and the mass of each of Composition A and Composition B was
measured. The mass ratio of Composition B (W.sub.B) to Composition
A (W.sub.A) was calculated.
[0039] Judgment on discharge property:
[0040] .circleincircle.: 1/1.1
.ltoreq.W.sub.B/W.sub.A.ltoreq.1.1
[0041] X: W.sub.B/W.sub.A<0.6 or W.sub.B/W.sub.A>1/0.6
1TABLE 1 (parts by mass) Composition Composition A-1 A-2
Carboxymethylcellulose (degree of 1.2 0.7 etherification: 1.0 to
1.5) Carboxymethylcellulose (degree of 0.2 0.4 etherification: 0.6
to 0.8) Silica (oil absorption amount: 130 mL/100 g) 6.0 6.0 Silica
(oil absorption amount: 260 mL/100 g) -- 14.0 Calcium carbonate
(average particle size: 14.0 -- 150 .mu.m) Sodium
monofluorophosphate 0.73 0.73 Sorbitol solution 40.83 40.83
Polyethylene glycol 600 4.0 4.0 Sodium saccharin 0.14 0.14 Sodium
lauryl sulfate 1.2 1.2 Flavor 1.0 1.0 Blue No. 1 (0.6%) 0.1 0.1
Purified water Balance Balance Initial modulus G' [Pa] 427 1600
Modulus G' at tan .delta. = 1 [Pa] 226 177
[0042]
2TABLE 2 (parts by mass) Composition Composition Composition
Composition Composition Composition B-1 B-2 B-3 B-4 B-5 B-6
Carboxymethylcellulose (degree of 1.1 1.1 1.1 1.1 1.1 0.9
etherification: 1.0 to 1.5) Carboxymethylcellulose (degree of 0 0 0
0 0 0.2 etherification: 0.6 to 0.8) Silica 8.0 7.0 6.0 5.0 4.0 5.0
(oil absorption amount: 130 mL/100 g) Silica 11.0 13.0 13.0 14.0
15.0 14.0 (oil absorption amount: 260 mL/100 g) Sodium fluoride 0.2
0.2 0.2 0.2 0.2 0.2 Sorbitol solution 38.5 38.5 38.5 38.5 38.5 38.5
Polyethylene glycol 600 4.0 4.0 4.0 4.0 4.0 4.0 Sodium saccharin
0.1 0.1 0.1 0.1 0.1 0.1 Sodium lauryl sulfate 1.2 1.2 1.2 1.2 1.2
1.2 Flavor 1.0 1.0 1.0 1.0 1.0 1.0 Purified water Balance Balance
Balance Balance Balance Balance Initial modulus G' [Pa] 2500 1700
946 564 147 776 Modulus G' at tan .delta. = 1 [Pa] 425 322 239 174
123 144
[0043] As is apparent from Table 3, ratios of the modulus,
G.sub.A'/G.sub.B', at tan .delta.=1 were 0.95 and 1.02,
respectively, in Examples 1 and 2, suggesting that the toothpastes
have a good discharge property. In each example, by controlling the
ratio G.sub.A'/G.sub.B' of the storage modulus of the compositions
to fall within a range of from 0.6/1 to 1/0.6, predetermined
amounts of compositions were discharged stably whenever the
toothpaste was squeezed.
[0044] On the other hand, in the toothpastes in Comparative
Examples 1 and 2, the ratios G.sub.A'/G.sub.B' of the storage
modulus at tan .delta.=1 were 0.53 and 0.55, respectively, and the
toothpastes had an inferior discharge property. Two-component type
toothpastes put on the American market were also tested for their
discharge property. The results are shown in Table 3. The ratios
G.sub.A'/G.sub.B' of the storage modulus of these pastes at tan 6=1
were both 0.46 and they were inferior in their discharge property.
In the toothpastes of Comparative Examples or commercially
available ones, two compositions differ greatly in G' and thus the
discharged amount of one of the compositions is excessively larger
or excessively smaller, resulting in a failure to stably discharge
predetermined amounts of the compositions each time they are
used.
3 TABLE 3 Comp. Comp. P&G Colgate Ex. 1 Ex. 2 Ex. 1 Ex. 2 Crest
Sensitive Compositions Group A A-1 A-2 A-1 A-2 Blue Blue paste
paste Group B B-3 B-4 B-1 B-2 White White paste paste Initial
modulus G' [Pa] Group A 427 1600 427 1600 540 375 Group B 946 564
2500 1700 1020 807 Modulus G' at tan .delta. = 1 Group A 226 177
226 177 97 85 [Pa] Group B 239 174 425 322 211 186 Ratio of modulus
G' at tan .delta. = 1 0.95 1.02 0.53 0.55 0.46 0.46
(G.sub.A'/G.sub.B') Discharge property .circleincircle.
.circleincircle. X X X X
Examples 3 and 4
[0045] Compositions A and B shown in Table 4 were prepared and they
were filled respectively in two 60-mL compartments of a toothpaste
container having the cross-section as shown in FIG. 1 (5).
[0046] The discharge property was evaluated as in Examples 1 and 2.
As a result, as apparent from Table 4, although each of the
Compositions (B) of Examples 3 and 4 and Comparative Examples 3 and
4 has a viscosity of 3000 dPa.multidot.S (25.degree. C.), the
ratios G.sub.A'/G.sub.B' s of the toothpastes of Examples 3 and 4
are 0.91 and 0.73, respectively, and these toothpastes have good
discharge properties. The ratios G.sub.A'/G.sub.B' S of the
toothpastes of Comparative Examples 3 and 4 are, on the other hand,
1.45 and 1.8, respectively, and these toothpastes have inferior
discharge properties. It is not always possible to discharge
predetermined amounts of the compositions stably by controlling the
viscosity of the compositions, but by adjusting the ratio
G.sub.A'/G.sub.B' of the storage modulus within a range of from 0.6
to 1.4, predetermined amounts of the compositions can be discharged
stably.
[0047] The toothpastes of Examples 3 and 4 did not undergo any
change in its discharge property and in components even if they
were discharged after storing at 25.degree. C. for 3 months.
4TABLE 4 (parts by mass) Example 3 Example 4 Comp. Ex. 3 Comp. Ex.
4 A B A B A B A B Calcium carbonate 25 -- 15 -- 35 -- 40 --
(average particle size: 150 .mu.m) Sodium pyrophosphate 2 -- 2 -- 2
-- 2 -- Sodium 0.73 -- 0.73 -- 0.73 -- 0.73 -- monofluorophosphate
Sodium fluoride 0.2 -- 0.2 -- 0.2 -- 0.2 Sorbitol solution (a 70
wt. % 36 40 36 40 36 40 36 40 solution) Polyethylene glycol 600 4 4
4 4 4 4 4 4 Sodium saccharin 0.13 0.13 0.13 0.13 0.13 0.13 0.13
0.13 Sodium lauryl sulfate 1.3 1.3 1.3 1.3 1.3 1.3 1.3 1.3 Silicic
acid anhydride 7 15 7 15 7 15 7 15 Sodium 1 1 1 1 1 1 1 1
carboxymethylcellulose Flavor 1 1 1 1 1 1 1 1 Purified water
Balance Balance Balance Balance Balance Balance Balance Balance
Total 100 100 100 100 100 100 100 100 Viscosity of composition 4000
3000 3000 3000 5000 3000 5500 3000 (dPa .multidot. s) 25.degree. C.
Storage modulus (G') 1000 1100 800 1100 1600 1100 2000 1100 Ratio
of storage modulus of 0.91 0.73 1.45 1.8 two compositions
(G.sub.A'/G.sub.B') Discharge property .circleincircle.
.circleincircle. X X
Industrial Applicability
[0048] In the toothpaste of the present invention containing
Composition A and Composition B filled separately in a container
having two separate chambers, it is possible to discharge the
compositions in predetermined amounts from the container by
controlling the ratio of the storage modulus G.sub.A' of
Composition (A) to the storage modulus G.sub.B' of Composition (B),
wherein said Composition A and Composition B are such compositions
which, if pre-mixed, will otherwise cause time-dependent change and
fail to achieve the intended purpose of the invention.
* * * * *