U.S. patent application number 10/717523 was filed with the patent office on 2004-08-05 for nonaerosol/aerosol dispensing of sunscreen sprays comprising silica microparticles.
This patent application is currently assigned to SOCIETE L'OREAL S.A.. Invention is credited to Josso, Martin.
Application Number | 20040151673 10/717523 |
Document ID | / |
Family ID | 32776604 |
Filed Date | 2004-08-05 |
United States Patent
Application |
20040151673 |
Kind Code |
A1 |
Josso, Martin |
August 5, 2004 |
Nonaerosol/aerosol dispensing of sunscreen sprays comprising silica
microparticles
Abstract
Nonaerosol/atomizer pumps or aerosol dispensers comprise (A) a
reservoir confining at least one vaporizable sunscreen composition
suited for UV-photoprotecting the skin and/or hair against the
damaging effects of UV radiation, the at least one vaporizable
sunscreen composition comprising (1) a UV-photoprotecting amount of
at least one UV-sunscreen and (2) an SPF-enhancing amount of
generally spherical silica microparticles, formulated into (3) a
topically applicable, cosmetically acceptable carrier therefor, and
(B) at least one agent for pressurizing the at least one
vaporizable sunscreen composition into a spray of fine sunscreen
particles.
Inventors: |
Josso, Martin; (Paris,
FR) |
Correspondence
Address: |
BURNS DOANE SWECKER & MATHIS L L P
POST OFFICE BOX 1404
ALEXANDRIA
VA
22313-1404
US
|
Assignee: |
SOCIETE L'OREAL S.A.
Paris
FR
|
Family ID: |
32776604 |
Appl. No.: |
10/717523 |
Filed: |
November 21, 2003 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
|
|
60449574 |
Feb 26, 2003 |
|
|
|
Current U.S.
Class: |
424/47 ;
424/59 |
Current CPC
Class: |
A61K 8/0279 20130101;
A61K 2800/412 20130101; A61Q 17/04 20130101; A61K 8/25 20130101;
A61K 8/046 20130101 |
Class at
Publication: |
424/047 ;
424/059 |
International
Class: |
A61K 007/00; A61K
009/00; A61K 007/42 |
Foreign Application Data
Date |
Code |
Application Number |
Nov 21, 2002 |
FR |
02/14599 |
Claims
What is claimed is:
1. A nonaerosol/atomizer pump or aerosol dispenser which comprises
(A) a reservoir confining at least one vaporizable sunscreen
composition suited for UV-photoprotecting the skin and/or hair
against the damaging effects of UV radiation, said at least one
vaporizable sunscreen composition comprising (1) a
UV-photoprotecting amount of at least one UV-sunscreen and (2) an
SPF-enhancing amount of generally spherical silica microparticles,
formulated into (3) a topically applicable, cosmetically acceptable
carrier therefor, and (B) at least one agent for pressurizing said
at least one vaporizable sunscreen composition into a spray of fine
sunscreen particles.
2. The atomizer/aerosol dispenser as defined by claim 1, said at
least one vaporizable sunscreen composition comprising (2) an
SPF-enhancing amount of generally spherical porous silica
microparticles, formulated into (3) a topically applicable,
cosmetically acceptable aqueous carrier therefor.
3. The atomizer/aerosol dispenser as defined by claim 2, said
generally spherical porous silica microparticles having a mean
particle size ranging from 0.5 .mu.m to 20 .mu.m.
4. The atomizer/aerosol dispenser as defined by claim 3, said
generally spherical porous silica microparticles having a mean
particle size ranging from 3 .mu.m to 15 .mu.m.
5. The atomizer/aerosol dispenser as defined by claim 3, said
generally spherical porous silica microparticles having a specific
surface ranging from 50 m.sup.2/g to 1000 m.sup.2/g
6. The atomizer/aerosol dispenser as defined by claim 5, said
generally spherical porous silica microparticles having a specific
surface ranging from 150 m.sup.2/g to 800 m.sup.2/g.
7. The atomizer/aerosol dispenser as defined by claim 5, said
generally spherical porous silica microparticles having a specific
pore volume ranging from 0.5 ml/g to 5 ml/g.
8. The atomizer/aerosol dispenser as defined by claim 7, said
generally spherical porous silica microparticles having a specific
pore volume ranging from 1 ml/g to 2 ml/g.
9. The atomizer/aerosol dispenser as defined by claim 2, said
generally spherical porous silica microparticles comprising from
0.1% to 10% weight of said at least one vaporizable sunscreen
composition.
10. The atomizer/aerosol dispenser as defined by claim 2, said
generally spherical porous silica microparticles comprising from
0.2% to 5% weight of said at least one vaporizable sunscreen
composition.
11. The atomizer/aerosol dispenser as defined by claim 2, said at
least one vaporizable sunscreen composition comprising one or more
organic UV-screening agent(s) and/or one or more inorganic
UV-screening (nano)pigment(s).
12. The atomizer/aerosol dispenser as defined by claim 11, said at
least one vaporizable sunscreen composition comprising one or more
organic UV-screening agent(s) selected from the group consisting of
anthranilates; cinnamic derivatives; dibenzoylmethane derivatives;
salicylic derivatives, camphor derivatives; triazine derivatives;
benzophenone derivatives; .beta.,.beta.'-diphenyl acrylate
derivatives, benzotriazole derivatives, benzimidazole derivatives;
imidazolines; bisbenzoazolyl derivatives; p-aminobenzoic acid
(PABA) derivatives; methylenebis(hydroxyphenylbenzotriazole)
derivatives; benzoxazole derivatives; screening polymers and
screening silicones; dimers derived from .alpha.-alkylstyrene;
4,4-diarylbutadiene derivatives and mixtures thereof.
13. The atomizer/aerosol dispenser as defined by claim 12, said at
least one vaporizable sunscreen composition comprising one or more
organic UV-screening agent(s) selected from the group consisting of
Ethylhexyl Salicylate, Ethylhexyl Methoxycinnamate, Octocrylene,
Phenylbenzimidazole Sulphonic Acid, Benzophenone-3, Benzophenone-4,
Benzophenone-5, n-Hexyl
2-(4-diethylamino-2-hydroxybenzoyl)benzoate, 4-Methylbenzylidene
camphor, Terephthalylidene Dicamphor Sulphonic, Disodium Phenyl
Dibenzimidazole Tetra-sulphonate, 2,4,6-Tris(diisobutyl
4'-aminobenzalmalonate)-s-triazin- e, Anisotriazine, Ethylhexyl
triazone, Diethylhexyl Butamido Triazone, Methylene
bis-Benzotriazolyl Tetramethylbutylphenol, Drometrizole
Trisiloxane, Polysilicone-1,1-dicarboxy
(2,2'-dimthyl-propyl)-4,4-dipheny- lbutadiene,
2,4-bis-[5-1(dimthylpropyl)benzoxazol-2-yl-(4-phenyl)-imino]-6-
-(2-ethylhexyl)-imino-1,3,5-triazine and mixtures thereof.
14. The atomizer/aerosol dispenser as defined by claim 11, said at
least one vaporizable sunscreen composition comprising one or more
coated or uncoated metal oxide (nano)pigment(s).
15. The atomizer/aerosol dispenser as defined by claim 14, said at
least one vaporizable sunscreen composition comprising one or more
(nano)pigment(s) of titanium, iron, zinc, zirconium or cerium.
16. The atomizer/aerosol dispenser as defined by claim 2, said at
least one UV-sunscreen comprising from 0.1% to 30% by weight of
said at least one vaporizable sunscreen composition.
17. The atomizer/aerosol dispenser as defined by claim 2, said at
least one UV-sunscreen comprising from 0.5% to 15% by weight of
said at least one vaporizable sunscreen composition.
18. The atomizer/aerosol dispenser as defined by claim 2,
comprising (B) at least one propellant.
19. The atomizer/aerosol dispenser as defined by claim 2, said at
least one vaporizable sunscreen composition comprising at least one
self- or artificial tanning agent.
20. The atomizer/aerosol dispenser as defined by claim 19, said at
least one self- or artificial tanning agent comprising at least one
mono- or polycarbonyl compound.
21. The atomizer/aerosol dispenser as defined by claim 20, said at
least one self- or artificial tanning agent being selected from the
group consisting of isatin, alloxan, ninhydrin, glyceraldehyde,
mesotartaric aldehyde, glutaraldehyde, erythrulose,
pyrazolin-4,5-dione derivatives, dihydroxyacetone (DHA),
4,4-dihydroxypyrazolin-5-one derivatives and mixtures thereof.
22. The atomizer/aerosol dispenser as defined by claim 21, said at
least one self- or artificial tanning agent comprising DHA.
23. The atomizer/aerosol dispenser as defined by claim 19, said at
least one self- or artificial tanning agent comprising from 0.1% to
10% by weight of said at least one vaporizable sunscreen
composition.
24. The atomizer/aerosol dispenser as defined by claim 19, said at
least one self- or artificial tanning agent comprising from 0.2% to
8% by weight of said at least one vaporizable sunscreen
composition.
25. The atomizer/aerosol dispenser as defined by claim 2, said at
least one vaporizable sunscreen composition further comprising at
least one cosmetic additive or adjuvant selected from the group
consisting of fatty substances, organic solvents, thickeners,
demulcents, opacifiers, stabilizers, emollients, anti-foaming
agents, moisturizing agents, perfumes, preservatives, polymers,
fillers, sequestrants, bactericides and/or odor absorbers,
alkalinizing or acidifying agents, surfactants, emulsifiers,
anti-free radical agents, antioxidants, vitamins, .alpha.-hydroxy
acids and mixtures thereof.
26. The atomizer/aerosol dispenser as defined by claim 2, said at
least one vaporizable sunscreen composition further comprising at
least one polymer of isophthalic acid or of sulphoisophthalic
acid.
27. The atomizer/aerosol dispenser as defined by claim 26, said at
least one polymer of isophthalic acid or of sulphoisophthalic acid
comprising a copolymer of phthalate/sulphoisophthalate/glycol or a
copolymer of diethylene
glycol/phthalate/isophthalate/1,4-cyclohexanedimethanol.
28. The atomizer/aerosol dispenser as defined by claim 2, said at
least one vaporizable sunscreen composition comprising a simple or
complex emulsion.
29. The atomizer/aerosol dispenser as defined by claim 2, said at
least one vaporizable sunscreen composition comprising an
oil-in-water or water-in-oil emulsion.
30. A vaporizable sunscreen composition suited for pressurization
into a spray of fine sunscreen particles, comprising (1) a
UV-photoprotecting amount of at least one UV-sunscreen and (2) an
SPF-enhancing amount of generally spherical silica microparticles,
formulated into (3) a topically applicable, cosmetically acceptable
carrier therefor.
31. The vaporizable sunscreen composition as defined by claim 30,
comprising (2) an SPF-enhancing amount of generally spherical
silica microparticles, formulated into (3) a topically applicable,
cosmetically acceptable aqueous carrier therefor.
32. The vaporizable sunscreen composition as defined by claim 31,
said generally spherical porous silica microparticles having a mean
particle size ranging from 0.5 .mu.m to 20 .mu.m.
33. The vaporizable sunscreen composition as defined by claim 32,
said generally spherical porous silica microparticles having a mean
particle size ranging from 3 .mu.m to 15 .mu.m.
34. The vaporizable sunscreen composition as defined by claim 32,
said generally spherical porous silica microparticles having a
specific surface ranging from 50 m.sup.2/g to 1000 m.sup.2/g
35. The vaporizable sunscreen composition as defined by claim 34,
said generally spherical porous silica microparticles having a
specific surface ranging from 150 m.sup.2/g to 800 m.sup.2/g.
36. The vaporizable sunscreen composition as defined by claim 34,
said generally spherical porous silica microparticles having a
specific pore volume ranging from 0.5 ml/g to 5 ml/g.
37. The vaporizable sunscreen composition as defined by claim 36,
said generally spherical porous silica microparticles having a
specific pore volume ranging from 1 ml/g to 2 ml/g.
38. The vaporizable sunscreen composition as defined by claim 31,
said generally spherical porous silica microparticles comprising
from 0.1% to 10% weight of said at least one vaporizable sunscreen
composition.
39. The vaporizable sunscreen composition as defined by claim 31,
said generally spherical porous silica microparticles comprising
from 0.2% to 5% weight of said at least one vaporizable sunscreen
composition.
40. The vaporizable sunscreen composition as defined by claim 31,
said at least one vaporizable sunscreen composition comprising one
or more organic UV-screening agent(s) and/or one or more inorganic
UV-screening (nano)pigment(s).
41. The vaporizable sunscreen composition as defined by claim 40,
said at least one vaporizable sunscreen composition comprising one
or more organic UV-screening agent(s) selected from the group
consisting of anthranilates; cinnamic derivatives; dibenzoylmethane
derivatives; salicylic derivatives, camphor derivatives; triazine
derivatives; benzophenone derivatives; .beta.,.beta.'-diphenyl
acrylate derivatives, benzotriazole derivatives, benzimidazole
derivatives; imidazolines; bisbenzoazolyl derivatives;
p-aminobenzoic acid (PABA) derivatives;
methylenebis(hydroxyphenylbenzotriazole) derivatives; benzoxazole
derivatives; screening polymers and screening silicones; dimers
derived from .alpha.-alkylstyrene; 4,4-diarylbutadiene derivatives
and mixtures thereof.
42. The vaporizable sunscreen composition as defined by claim 41,
said at least one vaporizable sunscreen composition comprising one
or more organic UV-screening agent(s) selected from the group
consisting of Ethylhexyl Salicylate, Ethylhexyl Methoxycinnamate,
Octocrylene, Phenylbenzimidazole Sulphonic Acid, Benzophenone-3,
Benzophenone-4, Benzophenone-5, n-Hexyl
2-(4-diethylamino-2-hydroxybenzoyl)benzoate, 4-Methylbenzylidene
camphor, Terephthalylidene Dicamphor Sulphonic, Disodium Phenyl
Dibenzimidazole Tetra-sulphonate, 2,4,6-Tris(diisobutyl
4'-aminobenzalmalonate)-s-triazine, Anisotriazine, Ethylhexyl
triazone, Diethylhexyl Butamido Triazone, Methylene
bis-Benzotriazolyl Tetramethylbutylphenol, Drometrizole
Trisiloxane, Polysilicone-1,1-dicarb- oxy
(2,2'-dimthyl-propyl)-4,4-diphnylbutadine,
2,4-bis-[5-1(dimthylpropyl)-
benzoxazol-2-yl-(4-phenyl)-imino]-6-(2-ethylhexyl)-imino-1,3,5-triazine
and mixtures thereof.
43. The vaporizable sunscreen composition as defined by claim 40,
said at least one vaporizable sunscreen composition comprising one
or more coated or uncoated metal oxide (nano)pigment(s).
44. The vaporizable sunscreen composition as defined by claim 43,
said at least one vaporizable sunscreen composition comprising one
or more (nano)pigment(s) of titanium, iron, zinc, zirconium or
cerium.
45. The vaporizable sunscreen composition as defined by claim 31,
said at least one UV-sunscreen comprising from 0.1% to 30% by
weight of said at least one vaporizable sunscreen composition.
46. The vaporizable sunscreen composition as defined by claim 31,
said at least one UV-sunscreen comprising from 0.5% to 15% by
weight of said at least one vaporizable sunscreen composition.
47. The vaporizable sunscreen composition as defined by claim 31,
said at least one vaporizable sunscreen composition comprising at
least one self- or artificial tanning agent.
48. The vaporizable sunscreen composition as defined by claim 47,
said at least one self- or artificial tanning agent comprising at
least one mono- or polycarbonyl compound.
49. The vaporizable sunscreen composition as defined by claim 48,
said at least one self- or artificial tanning agent being selected
from the group consisting of isatin, alloxan, ninhydrin,
glyceraldehyde, mesotartaric aldehyde, glutaraldehyde, erythrulose,
pyrazolin-4,5-dione derivatives, dihydroxyacetone (DHA),
4,4-dihydroxypyrazolin-5-one derivatives and mixtures thereof.
50. The vaporizable sunscreen composition as defined by claim 49,
said at least one self- or artificial tanning agent comprising
DHA.
51. The vaporizable sunscreen composition as defined by claim 47,
said at least one self- or artificial tanning agent comprising from
0.1% to 10% by weight of said at least one vaporizable sunscreen
composition.
52. The vaporizable sunscreen composition as defined by claim 47,
said at least one self- or artificial tanning agent comprising from
0.2% to 8% by weight of said at least one vaporizable sunscreen
composition.
53. The vaporizable sunscreen composition as defined by claim 31,
said at least one vaporizable sunscreen composition further
comprising at least one cosmetic additive or adjuvant selected from
the group consisting of fatty substances, organic solvents,
thickeners, demulcents, opacifiers, stabilizers, emollients,
anti-foaming agents, moisturizing agents, perfumes, preservatives,
polymers, fillers, sequestrants, bactericides and/or odor
absorbers, alkalinizing or acidifying agents, surfactants,
emulsifiers, anti-free radical agents, antioxidants, vitamins,
.alpha.-hydroxy acids and mixtures thereof.
54. The vaporizable sunscreen composition as defined by claim 31,
said at least one vaporizable sunscreen composition further
comprising at least one polymer of isophthalic acid or of
sulphoisophthalic acid.
55. The vaporizable sunscreen composition as defined by claim 54,
said at least one polymer of isophthalic acid or of
sulphoisophthalic acid comprising a copolymer of
phthalate/sulphoisophthalate/glycol or a copolymer of diethylene
glycol/phthalate/isophthalate/1,4-cyclohexanedime- thanol.
56. The vaporizable sunscreen composition as defined by claim 31,
said at least one vaporizable sunscreen composition comprising a
simple or complex emulsion.
57. The vaporizable sunscreen composition as defined by claim 31,
said at least one vaporizable sunscreen composition comprising an
oil-in-water or water-in-oil emulsion.
58. A regime or regimen for UV-photoprotecting the skin and/or hair
against the damaging effects of UV radiation, comprising spraying
thereon an effective amount of fine sunscreen particles pressurized
from the vaporizable sunscreen composition as defined by claim
30.
59. A regime or regimen for UV-photoprotecting the skin and/or hair
against the damaging effects of UV radiation, comprising spraying
thereon an effective amount of fine sunscreen particles pressurized
from the vaporizable sunscreen composition as defined by claim 31.
Description
CROSS-REFERENCE TO PRIORITY/PROVISIONAL APPLICATIONS
[0001] This application claims priority under 35 U.S.C. .sctn. 119
of FR-02/14599, filed Nov. 21, 2002, and of provisional application
Serial No. 60/449,574, filed Feb. 26, 2003, both hereby expressly
incorporated by reference. This application is also a continuation
of said '574 provisional.
BACKGROUND OF THE INVENTION
[0002] 1. Technical Field of the Invention
[0003] The present invention relates to a pressurizing device or
dispenser comprising at least (A) a reservoir containing at least
one composition intended for protecting the skin and/or the hair
against ultraviolet radiation, said at least one composition which
comprises, in a cosmetically acceptable aqueous carrier, at least:
(a) a photoprotective system capable of screening out UV radiation;
(b) generally spherical microparticles of porous silica; and (B)
means which make it possible to put the at least one composition
under pressure.
[0004] 2. Description of Background/Related/Prior Art
[0005] It is known that light radiation having wavelengths of
between 280 nm and 400 nm allows tanning of the human epidermis,
and that radiation having wavelengths of between 280 nm and 320 nm,
known by the name UV-B radiation, causes erythemas and skin burns
which can impede the development of natural tanning; this UV-B
radiation should therefore be screened out.
[0006] It is also known that UV-A rays having wavelengths of
between 320 nm and 400 nm, which cause tanning of the skin, are
capable of inducing its impairment, in particular in the case of a
sensitive skin or of a skin continually exposed to solar radiation.
UV-A rays cause in particular a loss of elasticity of the skin and
the appearance of wrinkles which lead to premature skin aging. They
promote the onset of the erythematous reaction or amplify this
reaction in some subjects and may even be responsible for
phototoxic or photoallergic reactions. It is therefore desirable
also to screen out UV-A radiation.
[0007] Many cosmetic compositions intended for photoprotecting
(UV-A and/or UV-B) the skin are known to this art.
[0008] These anti-sun compositions are quite often provided in the
form of an oil-in-water type emulsion (that is to say a
cosmetically acceptable carrier consisting of an aqueous dispersing
continuous phase and an oily dispersed discontinuous phase) which
contains, in various concentrations, one or more lipophilic and/or
hydrophilic conventional organic screening agents capable of
selectively absorbing harmful UV radiation, these screening agents
(and their quantities) being selected according to the desired sun
protection factor, the sun protection factor (SPF) mathematically
expressing the ratio of the dose of UV radiation necessary to
achieve the erythematogenic threshold with the UV screening agent
to the dose of UV radiation necessary to achieve the
erythematogenic threshold without UV screening agent.
[0009] Accordingly, an increasing need exists for anti-sun or
sunscreen products having a high protection index. High protection
indices can be obtained by incorporating more screening agents in
high concentrations. This can not always be done since the addition
of large quantities of screening agents considerably increases the
cost of the anti-sun formulations and the risks of skin
irritation.
[0010] Anti-sun/sunscreen products provided in spray form are
increasingly sought by consumers because of their ease of use and
their cosmetic pleasantness.
[0011] Unlike conventional anti-sun milks and creams, it is
particularly difficult to obtain anti-sun compositions in spray
form having a high protection index.
SUMMARY OF THE INVENTION
[0012] After considerable research, it has now surprisingly and
unexpectedly been determined that including spherical
microparticles of porous silica in a pressurizing device confining
a composition containing at least one UV radiation screening
system, it is possible to obtain an anti-sun/sunscreen composition
having protection indices higher than those which may be obtained
with the same photoprotective system alone.
[0013] This discovery forms the basis of the present invention.
DETAILED DESCRIPTION OF BEST MODE AND SPECIFIC/PREFERRED
EMBODIMENTS OF THE INVENTION
[0014] Thus, the present invention features a pressurizing device
comprising at least (A) a reservoir containing at least one
composition intended for protecting the skin and/or the hair
against ultraviolet radiation, said at least one composition which
comprises, in a cosmetically acceptable aqueous carrier, at least:
(a) a photoprotective system capable of screening out UV radiation;
(b) spherical microparticles of porous silica; and (B) means which
make it possible to put said at least one composition under
pressure.
[0015] According to the invention, the expression photoprotective
system capable of screening out UV radiation is understood to
denote generally any compound or any combination of compounds
which, by mechanisms known per se of absorption and/or reflection
and/or diffusion of UV-A and/or UV-B radiation, makes it possible
to prevent, or at least limit, the coming of the said radiation
into contact with a surface (skin, hair) to which this or these
compounds have been applied. In other words, these compounds may be
UV absorbing photoprotective organic screening agents or inorganic
(nano)pigments diffusing and/or reflecting UV, and mixtures
thereof.
[0016] The present invention also features the use of spherical
microparticles of porous silica in a vaporizable composition
comprising, in a cosmetically acceptable aqueous carrier, at least
one photoprotective system capable of screening out UV radiation,
as agent which makes it possible to increase the sun protection
factor (SPF).
[0017] According to the invention, the expression "vaporizable
composition" is understood to denote in general any composition
which is capable of producing, under pressure in an appropriate
device or dispenser, fine particles.
[0018] Other characteristics, aspects and advantages of the present
invention will emerge on reading the detailed description which
follows.
[0019] The spherical microparticles of porous silica in accordance
with the invention preferably have a mean particle size ranging
from 0.5 .mu.m to 20 .mu.m and more particularly from 3 .mu.m to 15
.mu.m.
[0020] They preferably have a specific surface ranging from 50 to
1,000 m.sup.2/g and more particularly from 150 to 800
m.sup.2/g.
[0021] They preferably have a specific pore volume ranging from 0.5
to 5 ml/g and more particularly from 1 to 2 ml/g.
[0022] By way of example of microbeads of porous silica, it is
possible to use the following commercial products:
[0023] Silica Beads SB 150 from Myoshi
[0024] Sunsphere H-51 from Asahi Glass
[0025] Sunsil 130 from Sunjin
[0026] Spherica P-1500 from Ikeda Corporation
[0027] Sylosphere from Fuji Silysia.
[0028] The spherical microparticles of porous silica in accordance
with the present invention are used in the compositions in
accordance with the invention at concentrations preferably ranging
from 0.1% to 10% by weight relative to the total weight of the
composition and more particularly from 0.2% to 5% by weight.
[0029] According to the invention, the photoprotective system may
consist of one or more organic screening agents and/or one or more
inorganic (nano)pigments.
[0030] The organic screening agents are chosen in particular from
anthranilates; cinnamic derivatives; dibenzoylmethane derivatives;
salicylic derivatives, camphor derivatives; triazine derivatives
such as those described in U.S. Pat. No. 4,367,390, EP-863,145,
EP-517,104, EP-570,838, EP-796,851, EP-775,698, EP-878,469,
EP-933,376, EP-507,691, EP-507,692, EP-790,243 and EP-944,624;
benzophenone derivatives; .beta.,.beta.'-diphenyl acrylate
derivatives; benzotriazole derivatives; benzimidazole derivatives;
imidazolines; bis-benzoazolyl derivatives as described in
EP-669,323 and U.S. Pat. No. 2,463,264; p-aminobenzoic acid (PABA)
derivatives; methylenebis(hydroxyphenylbenzotriazole) derivatives
as described in U.S. Pat. Nos. 5,237,071, 5,166,355, GB-2,303,549,
DE-1,972,6 184 and EP-893,119; benzoxazole derivatives as described
in EP-0-832,642, EP-1-027,883, EP-1-300,137 and DE-10-162,844;
screening polymers and screening silicones such as those described
in particular in WO 93/04665; dimers derived from
.alpha.-alkylstyrene such as those described in DE-19,855,649;
4,4-diarylbutadienes such as those described in E-0-967,200,
DE-19-746,654, DE-19-755,649, EP-A-1008586, EP-1-133,980 and
EP-133,981 and mixtures thereof.
[0031] As examples of organic screening agents which are active in
the UV-A and/or UV-B range, there may be mentioned those designated
below under their INCI name:
[0032] para-Aminobenzoic Acid Derivatives:
[0033] PABA,
[0034] Ethyl PABA,
[0035] Ethyl Dihydroxypropyl PABA,
[0036] Ethylhexyl Dimethyl PABA sold in particular under the name
"ESCALOL 507" by ISP,
[0037] Glyceryl PABA,
[0038] PEG-25 PABA sold under the name "UVINUL P25" by BASF,
[0039] Salicylic Derivatives:
[0040] Homosalate sold under the name "Eusolex HMS" by Rona/EM
Industries, Ethylhexyl Salicylate sold under the name "NEO HELIOPAN
OS" by Haarmann and REIMER,
[0041] Dipropyleneglycol Salicylate sold under the name "DIPSAL" by
SCHER, TEA Salicylate, sold under the name "NEO HELIOPAN TS" by
Haarmann and REIMER,
[0042] Dibenzoylmethane Derivatives:
[0043] Butyl Methoxydibenzoylmethane sold in particular under the
trademark "PARSOL 1789" by HOFFMANN LA ROCHE,
[0044] Isopropyl Dibenzoylmethane,
[0045] Cinnamic Derivatives:
[0046] Ethylhexyl Methoxycinnamate sold in particular under the
trademark "PARSOL MCX" by HOFFMANN LA ROCHE,
[0047] Isopropyl Methoxy cinnamate,
[0048] Isoamyl Methoxy cinnamate sold under the trademark "NEO
HELIOPAN E 1000" by HAARMANN and REIMER,
[0049] Cinoxate,
[0050] DEA Methoxycinnamate,
[0051] Diisopropyl Methylcinnamate,
[0052] Glyceryl Ethylhexanoate Dimethoxycinnamate,
[0053] .beta.,.beta.'-Diphenyl Acrylate Derivatives:
[0054] Octocrylene sold in particular under the trademark "UVINUL
N539" by BASF, Etocrylene, sold in particular under the trademark
"UVINUL N35" by BASF,
[0055] Benzophenone Derivatives:
[0056] Benzophenone-1 sold under the trademark "UVINUL 400" by
BASF,
[0057] Benzophenone-2 sold under the trademark "UVINUL D50" by
BASF,
[0058] Benzophenone-3 or Oxybenzone, sold under the trademark
"UVINUL M40" by BASF,
[0059] Benzophenone-4 sold under the trademark "UVINUL MS40" by
BASF,
[0060] Benzophenone-5,
[0061] Benzophenone-6 sold under the trademark "Helisorb 11" by
Norquay,
[0062] Benzophenone-8 sold under the trademark "Spectra-Sorb UV-24"
by American Cyanamid,
[0063] Benzophenone-9 sold under the trademark "UVINUL DS-49" by
BASF, Benzophenone-12,
[0064] n-Hexyl 2-(4-diethylamino-2-hydroxybenzoyl)benzoate,
[0065] Benzylidenecamphor Derivatives:
[0066] 3-Benzylidene camphor manufactured under the name "MEXORYL
SD" by CHIMEX,
[0067] 4-Methylbenzylidene camphor sold under the name "EUSOLEX
6300" by MERCK,
[0068] Benzylidene Camphor Sulphonic Acid manufactured under the
name "MEXORYL SL" by CHIMEX,
[0069] Camphor Benzalkonium Methosulphate manufactured under the
name "MEXORYL SO" by CHIMEX,
[0070] Terephthalylidene Dicamphor Sulphonic Acid manufactured
under the name "MEXORYL SX" by CHIMEX,
[0071] Polyacrylamidomethyl Benzylidene Camphor manufactured under
the name "MEXORYL SW" by CHIMEX,
[0072] Benzimidazole Derivatives:
[0073] Phenylbenzimidazole Sulphonic Acid sold in particular under
the trademark "EUSOLEX 232" by MERCK, Disodium Phenyl
Dibenzimidazole Tetra-sulphonate sold under the trademark "NEO
HELIOPAN AP" by Haarmann and REIMER,
[0074] Triazine Derivatives:
[0075] Anisotriazine sold under the trademark "TINOSORB S" by CIBA
SPECIALTY CHEMICALS,
[0076] Ethylhexyl triazone sold in particular under the trademark
"UVINUL T150" by BASF,
[0077] Diethylhexyl Butamido Triazone sold under the trademark
"UVASORB HEB" by SIGMA 3V,
[0078] 2,4,6-Tris(diisobutyl
4'-aminobenzalmalonate)-s-triazine,
[0079] Benzotriazole Derivatives:
[0080] Drometrizole Trisiloxane sold under the name "Silatrizole"
by RHODIA CHIMIE, Methylene bis-Benzotriazolyl
Tetramethylbutylphenol, sold in solid form under the trademark
"MIXXIM BB/100" by FAIRMOUNT CHEMICAL or in micronized form in
aqueous dispersion under the trademark "TINOSORB M" by CIBA
SPECIALTY CHEMICALS,
[0081] Anthranilic Derivatives:
[0082] Menthyl anthranilate sold under the trademark "NEO HELIOPAN
MA" by Haarmann and REIMER,
[0083] Imidazoline Derivatives:
[0084] Ethylhexyl Dimethoxybenzylidene Dioxoimidazoline
Propionate,
[0085] Benzalmalonate Derivatives:
[0086] Polyorganosiloxane with benzalmalonate functional groups as
the product Polysilicone-15 sold under the trademark "PARSOL SLX"
by HOFFMANN LA ROCHE,
[0087] 4,4-Diarylbutadiene Derivatives:
[0088]
1,1-Dicarboxy-(2,2'-dimethylpropyl)-4,4-diphenylbutadiene
[0089] Benzoxazole Derivatives:
[0090]
2,4-bis-[5-1(dimthylpropyl)benzoxazol-2-yl-(4-phenyl)-imino]-6-(2-e-
thylhexyl)-imino-1,3,5-triazine sold under the trademark Uvasorb
K2A by Sigma 3V; and mixtures thereof.
[0091] The organic screening agents which are more particularly
preferred are chosen from the following compounds:
[0092] Ethylhexyl Salicylate,
[0093] Butyl Methoxydibenzoylmethane,
[0094] Ethylhexyl Methoxycinnamate,
[0095] Octocrylene,
[0096] Phenylbenzimidazole Sulphonic Acid,
[0097] Benzophenone-3,
[0098] Benzophenone-4,
[0099] Benzophenone-5,
[0100] n-Hexyl 2-(4-diethylamino-2-hydroxybenzoyl)benzoate,
[0101] 4-Methylbenzylidene camphor,
[0102] Terephthalylidene Dicamphor Sulphonic Acid,
[0103] Disodium Phenyl Dibenzimidazole Tetra-sulphonate,
[0104] 2,4,6-Tris(diisobutyl
4'-aminobenzalmalonate)-s-triazine,
[0105] Anisotriazine,
[0106] Ethylhexyl triazone,
[0107] Diethylhexyl Butamido Triazone,
[0108] Methylene bis-Benzotriazolyl Tetramethylbutylphenol,
[0109] Drometrizole Trisiloxane,
[0110] Polysilicone-15,
[0111]
1,1-Dicarboxy-(2,2'-dimethylpropyl)-4,4-diphenyl-butadiene,
[0112]
2,4-bis-[5-1(dimthylpropyl)benzoxazol-2-yl-(4-phenyl)-imino]-6-(2-e-
thylhexyl)-imino-1,3,5-triazine sold under and mixtures
thereof.
[0113] The inorganic screening agents are chosen from pigments or
nanopigments (mean primary particle size: generally between 5 nm
and 100 nm, preferably between 10 nm and 50 nm) of metal oxides,
coated or otherwise, such as for example nanopigments of titanium
oxide (amorphous or crystallized in rutile and/or anatase form), of
iron oxide, of zinc oxide, of zirconium oxide or of cerium oxide
which are all UV photoprotective agents well known per se.
Conventional coating agents are moreover alumina and/or aluminum
stearate. Such coated or uncoated nanopigments of metal oxides are
described in particular in EP-518,772 and EP-518,773.
[0114] The photoprotective system according to the invention is
generally present in the compositions according to the invention in
an amount ranging from 0.1% to 30% by weight and preferably from
0.5% to 15% by weight, relative to the total weight of the
composition.
[0115] The vaporizable compositions in accordance with the
invention are applied to the skin or the hair in the form of fine
particles by means pressurizing devices. The devices in accordance
with the invention are well known to persons skilled in the art and
comprise nonaerosol or "atomizer" pumps, aerosol containers
comprising propellants and aerosol pumps using compressed air as
propellant. The latter are described in U.S. Pat. Nos. 4,077,441
and 4,850,517 (which form an integral part of the content of the
description).
[0116] The compositions packaged as an aerosol in accordance with
the invention contain in general conventional propelling agents
such as for example the hydrofluorinated compounds
dichlorodifluoromethane, difluoroethane, dimethyl ether, isobutane,
n-butane, propane or trichlorofluoromethane. They are preferably
present in quantities ranging from 15% to 50% by weight relative to
the total weight of the composition.
[0117] The compositions according to the invention may also contain
agents for artificially bronzing and/or tanning the skin
(self-tanning agents).
[0118] The self-tanning agents are generally chosen from mono- or
polycarbonyl compounds such as for example isatin, alloxan,
ninhydrin, glyceraldehyde, mesotartaric aldehyde, glutaraldehyde,
erythrulose, pyrazolin-4,5-dione derivatives as described in
FR-2-466,492 and WO 97/35842, dihydroxyacetone (DHA),
4,4-dihydroxypyrazolin-5-one derivatives as described in
EP-903,342. DHA will preferably be used.
[0119] DHA may be used in free form and/or encapsulated for example
into lipid vesicles such as liposomes, described in particular in
WO 97/25970.
[0120] The mono- or polycarbonyl self-tanning agents are generally
present in the compositions according to the invention in
proportions ranging from 0.1% to 10% by weight relative to the
total weight of the composition, and preferably from 0.2% to 8% by
weight relative to the total weight of the composition.
[0121] The compositions of the invention may additionally comprise
conventional cosmetic adjuvants chosen in particular from fatty
substances, organic solvents, thickeners, demulcents, opacifiers,
stabilizers, emollients, anti-foaming agents, moisturizing agents,
perfumes, preservatives, polymers, fillers, sequestrants,
bactericides and/or odor absorbers, alkalinizing or acidifying
agents, surfactants, emulsifiers, anti-free radical agents,
antioxidants, vitamins such as vitamins E and C, .alpha.-hydroxy
acids or any other ingredient normally used in cosmetics, in
particular for the manufacture of vaporizable aqueous anti-sun
compositions.
[0122] The fatty substances may consist of an oil or a wax or
mixtures thereof, and they also comprise fatty acids, fatty
alcohols and fatty acid esters. The oils may be chosen from animal,
vegetable, mineral or synthetic oils and in particular from liquid
paraffin, paraffin oil, volatile or nonvolatile silicone oils,
isoparaffins, polyolefins, fluorinated and perfluorinated oils.
Likewise, the waxes may be chosen from animal, fossil, vegetable,
mineral or synthetic waxes known per se.
[0123] Among the organic solvents, there may be mentioned lower
alcohols and polyols.
[0124] The thickeners may be chosen in particular from crosslinked
acrylic polymers such as Carbomers, crosslinked
acrylate/C.sub.10-C.sub.30 alkyl acrylate polymers of the Pemulen
type or polyacrylate-3 sold under the name VISCOPHOBE DB 1000 by
Amerchol; polyacrylamides such as the emulsion polyacrylamide,
C.sub.13-C.sub.14 isoparaffin and laureth-7 sold under the name
SEPIGEL 305 by SEPPIC, homopolymers or copolymers of AMPS such as
HOSTACERIN AMPS sold by CLARIANT, guar gums and celluloses,
modified or otherwise, such as hydroxypropylated guar gum,
methylhydroxyethylcellu- lose and hydroxypropylmethylcellulose,
xanthan gum, nanometric silicas of the Aerosil type.
[0125] The emulsifying agents or emulsion stabilizers may be chosen
from nonionic, anionic or cationic surfactants. Among the emulsion
stabilizers, there will be used more particularly polymers of
isophthalic acid or of sulphoisophthalic acid, and in particular
copolymers of phthalate/sulphoisophthalate/glycol (for example
diethylene glycol/phthalate/isophthalate/1,4-cyclohexanedimethanol)
sold under the names "Eastman AQ polymer" (AQ35S, AQ38S, AQ55S,
AQ48 Ultra) by the company Eastman Chemical.
[0126] Of course, those skilled in the art will be careful to
choose the possible additional compound or compounds cited above
and/or their quantities such that the advantageous properties
intrinsically attached to the combination [photoprotective
system+microbeads of porous silica] in accordance with the
invention are not, or not substantially, impaired by the
addition(s) envisaged.
[0127] The compositions according to the invention may be prepared
according to techniques well known to persons skilled in the art,
intended for the preparation of vaporizable formulations.
[0128] The compositions according to the invention are preferably
provided in the form of a simple or complex emulsion (O/W, W/O,
O/W/O or W/O/W) such as a cream or a milk, and more particularly in
the form of a lotion.
[0129] More preferably, the compositions according to the invention
are provided in the form of an oil-in-water or water-in-oil
emulsion.
[0130] When it is an emulsion, the aqueous phase thereof may
comprise a nonionic vesicular dispersion prepared according known
methods (Bangham, Standish and Watkins, J. Mol. Biol. 13, 238
(1965), FR-2-315,991 and FR-2-416,008).
[0131] In order to further illustrate the present invention and the
advantages thereof, the following specific examples are given, it
being understood that same are intended only as illustrative and in
nowise limitative. In said examples to follow, all parts and
percentages are given by weight, unless otherwise indicated.
EXAMPLE 1
[0132] An anti-sun formulation A according to the invention capable
of being packaged as a nonaerosol or aerosol spray and capable of
being dispensed in the form of fine particles was prepared.
1 QUANTITY % FORMULATION A BY WEIGHT Octocrylene(UVINUL N539) 10
Ethylhexyl triazone (UVINUL T150) 1 Drometrizole
trisiloxane(Mexoryl XL) 3 Butyl methoxydibenzoylmethane 3 (Parsol
1789) Terephthalylidene dicamphor sulfonic 0.5 acid (MEXORYL SX)
Titanium dioxide 5 C.sub.12-C.sub.15 alkyl benzoate 6 Jojoba oil 1
Shea butter 1 Cyclohexasiloxane (DC Fluid 246 5 from Dow Corning)
Glycerin 6 Propylene glycol 6 Microbeads of porous silica (Silica 1
Beads SB 150 from Myoshi) Copolymer of 1 Diglycol/Cyclohexanedimet-
hanol/ isophthalates/Sulphoisophthalates (AQ 38S from EASTMAN)
Polyacrylate-3 as an emulsion at 25% 0.5 (VISCOPHOBE DB 1000 from
Amerchol) 0.5 Mixture of natural tocopherols and 0.2 soya-bean oil
Triethanolamine qs Preservatives qs Water qs 100
[0133] A comparative anti-sun formulation B was then prepared,
having the same carrier as formulation A but containing no
microbeads of porous silica.
[0134] For each of the compositions A and B, the sun protection
factor (SPF) which was attached to it was then determined. This was
determined using the in vitro method described by B. L. DIFFEY et
al., in J. Soc. Cosmet. Chem. 40 127-133 (1989); this method
consists in determining the monochromatic protection factors in a
range of wavelengths from 290 nm to 400 nm and in calculating from
them the sun protection factor according to a given mathematical
equation. The measurement was carried out with a step of 1 nm on a
UV-1000S apparatus from the company Labsphere, 2 mg/cm.sup.2 of
product being spread on the Transpore.RTM. strip.
[0135] The results (mean value corresponding to five trials) are
grouped together in the Table below:
2TABLE B (not in accordance A (invention) with with the invention)
microbeads of porous without microbead of Composition silica porous
silica Mean SPF (standard 21.5 15.5 deviation) (2.6) (2.8)
[0136] These results clearly show that the addition, in a
vaporizable carrier, of spherical microparticles of porous silica
to a photoprotective system consisting of octocrylene, butyl
methoxydibenzoylmethane, ethylhexyl triazone, Drometrizole
trisiloxane, Terephthalylidene dicamphor sulphonic acid and
nanopigments of TiO.sub.2, makes it possible to significantly
increase its sun protection factor.
[0137] Each patent, patent application, publication and literature
article/report cited or indicated herein is hereby expressly
incorporated by reference.
[0138] While the invention has been described in terms of various
specific and preferred embodiments, the skilled artisan will
appreciate that various modifications, substitutions, omissions,
and changes may be made without departing from the spirit thereof.
Accordingly, it is intended that the scope of the present invention
be limited solely by the scope of the following claims, including
equivalents thereof.
* * * * *