U.S. patent application number 10/720985 was filed with the patent office on 2004-07-22 for device for administering an injectable product.
Invention is credited to Michel, Peter.
Application Number | 20040143217 10/720985 |
Document ID | / |
Family ID | 7918703 |
Filed Date | 2004-07-22 |
United States Patent
Application |
20040143217 |
Kind Code |
A1 |
Michel, Peter |
July 22, 2004 |
Device for administering an injectable product
Abstract
The invention relates to a device for administering an
injectable product, comprising: a) a casing (3); b) a container for
said product accommodated by said casing (3) c) a delivering means
(2) for delivering product out of said container (1); d) a drive
means (8); and e) a transmission link via which said drive means
(8) drives said delivering means (2). The device is characterised
in that: f) a fluid space (21, 22) for an incompressible fluid and
g) a pressure reducing means (3, 10, 23) are provided in said
transmission link; h) wherein said fluid space (21, 22) can be
impinged on a drive side by pressure from said drive means (8) and
said pressure reducing means (3, 10, 23) reduces a fluid pressure
generated by said drive means (8) toward a driven side of said
fluid space (21, 22).
Inventors: |
Michel, Peter; (Burgdorf,
CH) |
Correspondence
Address: |
David E. Bruhn
DORSEY & WHITNEY LLP
Intellectual Property Department, Suite 1500
50 South Sixth Street
Minneapolis
MN
55402-1498
US
|
Family ID: |
7918703 |
Appl. No.: |
10/720985 |
Filed: |
November 24, 2003 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
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10720985 |
Nov 24, 2003 |
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10077229 |
Feb 15, 2002 |
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6736795 |
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10077229 |
Feb 15, 2002 |
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PCT/CH00/00390 |
Jul 18, 2000 |
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Current U.S.
Class: |
604/131 |
Current CPC
Class: |
A61M 5/1454 20130101;
A61M 2005/14513 20130101; A61M 5/14566 20130101; A61M 2205/3331
20130101 |
Class at
Publication: |
604/131 |
International
Class: |
A61M 037/00 |
Foreign Application Data
Date |
Code |
Application Number |
Aug 18, 1999 |
DE |
DE 199 39 023 A1 |
Claims
What is claimed is:
1. A device for administering an injectable product, comprising: a)
a casing; b) a container for said product accommodated by said
casing; c) a delivering means for delivering product out of said
container; d) a drive means; and e) a transmission link via which
said drive means drives said delivering means; characterised in
that: f) a fluid space for an incompressible fluid and g) a
pressure reducing means are provided in said transmission link; h)
wherein said fluid space can be impinged on a drive side by
pressure from said drive means and said pressure reducing means
reduces a fluid pressure generated by said drive means toward a
driven side of said fluid space.
2. The device as set forth in claim 1, characterised in that a
working stroke of said drive means is transmitted in said fluid
space into a working stroke of said delivering means which is
greater than the working stroke of said drive means.
3. The device as set forth in the preceding claim, characterised in
that a bias of said drive means is determined by a replaceably
arranged distance ring.
4. The device as set forth in claim 1, characterised in that said
drive side of said fluid space is formed by a piston area of a
drive piston which is larger than a piston area of a driven piston
which forms the driven side of said fluid space.
5. The device as set forth in claim 1, characterised in that said
fluid space is sub-divided into a first partial space including
said drive side and a second partial space including said driven
side, and in that said two partial spaces are connected to each
other by a fluid connection formed by said pressure reducing
means.
6. The device as set forth in the preceding claim, characterised in
that said two partial spaces are connected to each other
exclusively by a system of capillaries, if a higher pressure
prevails in said first partial space than in said second partial
space.
7. The device as set forth in claim 5, characterised in that said
fluid connection includes a spiral fluid channel or is formed by
the same.
8. The device as set forth in the preceding claim, characterised in
that said pressure reducing means comprises a capillary body, and
in that said spiral fluid channel is formed between a surface area
of said capillary body and an opposite surface area.
9. The device as set forth in claim 5, characterised in that said
first partial space or said second partial space is formed as a
toroidal chamber between an outer sleeve and an inner sleeve, and
in that the other of said two partial fluid spaces is formed in
said inner sleeve.
10. The device as set forth in the preceding claim, characterised
in that: said toroidal chamber forms said first partial space; and
a drive piston guided fluid-proof by said outer sleeve and said
inner sleeve forms said drive side.
11. The device as set forth in claim 9, characterized in that: said
second partial space is formed in said inner sleeve; and in that a
driven piston guided fluid-proof by said inner sleeve forms said
driven side.
12. The device as set forth in claim 9, characterized in that: said
pressure reducing means comprises a separating body which forms a
front face of said toroidal chamber and which separates said two
partial fluid spaces from each other; a valve is accommodated by
said separating body, said valve only allows a flow of fluid from
said driven side to said drive side of said fluid space; and in
that said separating body forms said fluid correction.
Description
BACKGROUND OF THE INVENTION
[0001] 1. Technical Field
[0002] The invention relates to a device for administering an
injectable product.
[0003] 2. Description of the Related Art
[0004] Injection devices, for example injection syringes or
injection pens, such as the invention relates to in particular
though not exclusively, conventionally comprise a casing which
accommodates an ampoule with the product to be injected, a
delivering means for delivering the product out of the ampoule and
a coupling means. The delivering means is conventionally formed by
a piston which is movable in the ampoule. In simple syringes, the
muscular power of the user serves as the drive means. The use of
spring elements, in particular pressure springs, as the drive means
is also known. The coupling means forms a transmission link or
drive connection from the drive means to the delivering means.
[0005] The known drive means, for example drive springs, have the
disadvantage that the drive force or drive energy applied by them
is subject to changes in the course of being released. In drive
springs, the drive energy changes in accordance with the spring
characteristic. The delivering rate of the delivering means follows
such changes. Correspondingly, the delivery rate changes in the
course of delivery in accordance with the changing drive
energy.
SUMMARY OF THE INVENTION
[0006] It is an object of the invention to provide a device for
administering an injectable product, with which the product is
evenly delivered in the course of an injection or infusion.
[0007] The invention is based on a device for administering an
injectable product which includes a casing, a container for the
product accommodated by the casing, a delivering means, a drive
means and a transmission link or coupling means. The product is
delivered directly out of the container by the delivering means.
The drive means supplies the drive energy required for this, said
drive energy being transmitted in the transmission link to the
delivering means, in such a way that the delivering means is driven
by the drive means, to deliver the product.
[0008] The container, the delivering means, the drive means and the
transmission members of the transmission link are preferably
arranged in the casing. Other arrangements are, however, in
principle equally possible. The injectable product is preferably a
medical or cosmetic agent, in particular in the form of a liquid
active solution. A prominent example is insulin, administered using
the device within the context of a treatment for diabetes. The
device is preferably an infusion device. It can, however, also be
an injection device. The container can, in particular, be formed as
an ampoule, as is the case in known infusion devices. The
delivering means is preferably formed by a piston accommodated by
the container, which is advanced towards an outlet of the
container, to deliver the product. However, instead of such a
piston, the delivering means can in principle be formed by any type
of pump suitable for delivering the product.
[0009] According to its type, the drive means is preferably formed
in such a way that it releases the energy stored in it when it is
triggered. Via a coupling means, this released energy is
transmitted in the transmission link to the delivering means which,
driven for its part in this way, delivers the product out of the
container. The drive means is preferably formed by a drive spring,
particularly preferably a pressure spring. In principle, however,
other designs of drive means may also be used, e.g. those which
release a pressure gas when triggered.
[0010] According to the invention, a fluid space for an
incompressible fluid and a pressure reducing means are provided in
the transmission link from the drive means to the delivering means,
i.e. in the coupling means.
[0011] The fluid space correspondingly comprises a drive side, upon
which the drive means acts, and a driven side, which acts on the
delivering means. Both the drive side and the driven side can be
connected, directly or via other transmission members, to the drive
means and/or delivering means respectively. The fluid space can be
impinged on its drive side by pressure from the drive means. The
pressure thus generated is reduced toward the driven side of the
fluid space by the pressure reducing means. The pressure is
preferably reduced to a fifth or less and particularly preferably
to a tenth or less by means of the pressure reducing means. The
pressure reducing means creates a fluid connection which only
allows a delayed flow of the fluid from the drive side towards the
driven side, such that in a dynamic state, i.e. while the
delivering means is being driven, a greater fluid pressure prevails
on the drive side than on the driven side.
[0012] The invention enables a drive means to be used in which
substantially more energy is stored than would be required to drive
the delivering means and the resulting delivery of the product. The
comparatively large drive energy released when the drive means is
triggered is attenuated by the fluid coupling in accordance with
the invention onto the measure required for delivering and
administering. The excess of drive energy is available, controlled
due to the fluid coupling in accordance with the invention, for
driving the delivering means. If a drive spring is used as the
drive means, as is preferred, then the spring strength of this
drive means can be significantly higher than in the case of a
direct drive connection to the delivering means. In particular,
such a drive spring can be operated in a smaller range of its
spring characteristic than would be possible in the case of a
direct coupling.
[0013] Particularly preferably, a working stroke of the drive means
is transmitted into a working stroke of the delivering means by the
fluid coupling, said working stroke of the delivering means being
greater than the working stroke of the drive means. In the case of
a pressure or tension spring as the drive means and a piston as the
delivering means, the respective working stroke is the stretching
or straining of the spring and the distance covered by the piston
in dependence on this working stroke.
[0014] Particularly preferably, the delivering means is formed as a
piston and the drive means likewise acts on a piston, designated in
the following as a drive piston. In this embodiment, the drive side
of the fluid space is formed by a piston area of the drive piston.
The piston area of the drive piston is preferably larger than a
piston area of a driven piston, wherein the piston area of the
driven piston forms the driven side of the fluid space.
[0015] Through this ratio of the two piston areas, a stroke of the
drive piston is transmitted into a comparatively larger stroke of
the driven piston. Expressed differently, a smaller stroke of the
drive piston is required to achieve a given stroke of the driven
piston. The working stroke of the drive piston can be kept
correspondingly short. The drive means can be operated in a tight
range around its optimal operating point. Furthermore, the
different-sized piston areas lead to a reduction of force. The
force exerted by the drive piston is reduced in accordance with the
ratio of the areas of the drive piston and driven piston. This
reduction occurs in addition to the reduction of force as a result
of the reduction of pressure. The Applicant reserves the right to
independently further prosecute the feature of the different-sized
piston areas, together with features a) to e) of claim 1.
[0016] The driven piston can form the delivering means directly.
The driven piston is, however, preferably another piston.
[0017] In a particularly preferred example embodiment, the fluid
space is sub-divided into a first partial space including the drive
side and a second partial space including the driven side, and the
two partial spaces are connected to each other exclusively by a
system of capillaries, if a higher pressure prevails on the drive
side than on the driven side of the fluid space. The system of
capillaries can be formed by a single capillary or also by a
plurality of capillaries.
[0018] The capillary or plurality of capillaries is/are
advantageously as long as possible. Its/their length is preferably
at least 0.5 m. If a plurality of capillaries are formed, this
preferably applies to each of the capillaries. The through-flow
rate in long capillaries is less dependent on the diameter of the
capillary, as directly follows from the Hagen-Poiseuille Law.
According to the Hagen-Poiseuille Law, variations in the diameter
due to imprecision in production enter into the through-flow rate
in the fourth power. However, with an increasing length of the
capillary, its diameter can likewise be enlarged, if the
through-flow rate is to remain constant. Larger diameters are on
the one hand by their very nature simpler to produce than smaller
diameters, and with an increasing size of the diameter, deviations
from the desired diameter arise to an increasingly less important
extent only. Furthermore, an as high viscosity of the working fluid
as possible in the fluid space is preferred.
[0019] The system of capillaries preferably comprises a capillary
running spirally, or a plurality of such capillaries. In a
preferred example embodiment, the system of capillaries is formed
by a single, spiral capillary. A spiral capillary not only has the
advantage of a large length, but can also be simply produced. In
particular, it can be formed in the form of an external or internal
thread on a corresponding surface area, preferably a shell or
jacket surface area, of a capillary body. The capillary body with
the external or internal thread is preferably placed into or onto
another body with a smooth opposite surface area, wherein care must
be taken that the threads of the capillary body are sealed against
each other on the opposite surface area.
BRIEF DESCRIPTION OF THE DRAWINGS
[0020] The invention will now be described by way of a preferred
example embodiment. There is shown:
[0021] FIG. 1 an infusion device in a longitudinal section;
[0022] FIG. 2 a capillary in accordance with Detail I of FIG. 1;
and
[0023] FIG. 3 an alternative embodiment of a capillary.
DETAILED DESCRIPTION
[0024] FIG. 1 shows a longitudinal section of an infusion
device.
[0025] A circular cylindrical outer sleeve 3, together with a
sealing piece 9 at a proximal end and a sealing cap 19 at a distal
end, forms a casing of the infusion device. A container holder 4a
is held centred in a proximal region of the outer sleeve 3. A
container 1 in the form of an ampoule is accommodated by the
container holder 4a, likewise centred with respect to the central
longitudinal axis of the outer sleeve 3. The container 1 is filled
with a product to be injected, for example insulin. A delivering
means 2 in the form of a delivering piston is furthermore movably
accommodated by the container, in a straight line toward an outlet
of the container 1. A catheter 20 is connected to the outlet of the
container 1 in a manner known in its own right
[0026] An inner sleeve 4b is arranged in a distal region of the
infusion device, concentric with respect to the outer sleeve 3. In
the example embodiment, the container holder 4a and the inner
sleeve 4b are formed as a one-piece sleeve. The container holder 4a
and the inner sleeve 4b could also be separate components. However,
forming them as one piece simplifies holding them commonly centred
in the outer sleeve 3, as can be directly inferred from FIG. 1 and
the subsequent description.
[0027] An inner surface area of the inner sleeve 4b forms a slide
bearing for a driven piston 6 accommodated by the inner sleeve 4b,
said driven piston being connected rigidly to the delivering piston
2 by means of a piston rod 7. The driven piston 6 and the piston
rod 7 are formed as one piece. The piston rod 7 abuts the
delivering piston 2. It could also be firmly connected to the
delivering piston 2; for example, it could be screwed to the
delivering piston 2. Furthermore, the piston rod 7 can equally be
guided into a collar region between the container holder 4a and the
inner sleeve 4b, for example guided fluid-proof. The driven piston
6 seals toward the inner sleeve 4b using sealing rings 17 in the
manner of piston rings.
[0028] A ring space is formed between the outer sleeve 3 and the
inner sleeve 4b, a drive piston 5 being arranged in said ring
space. The drive piston 5 is a ring piston which is slid back and
forth, fluid-proof and tight, between the outer sleeve 3 and the
inner sleeve 4b. Sealing rings 15 are accommodated by grooves in an
inner surface area of the drive piston 5 and other sealing rings 16
are accommodated by grooves on an outer surface area of the drive
piston 5, each in the manner of piston rings. The drive piston 5
comprises a plane ring area on a distal front face. The drive
piston 5 tapers toward the inner sleeve 4b in the proximal
direction. The taper is formed by means of a collar. An opposite
area of the infusion device lies opposite the collar, seen in the
proximal direction. The opposite area is formed by a distance piece
in the form of a distance ring 9a, which surrounds the container
holder 4a and lies loose on the sealing piece 9.
[0029] In a ring space between the outer sleeve 3 on the one hand
and the container holder 4a and the inner sleeve 4b on the other, a
pressure spring 8 is accommodated between the two opposing areas,
i.e. the collar of the drive piston 5 and the distance ring 9a,
abutting the two areas. By varying the strength of the distance
ring 9a, i.e. by exchanging it, the device can be simply adapted to
different pressure springs 8, to continuously set the operative
range of the spring optimally.
[0030] A capillary body 10 is arranged behind the drive piston 5 in
the distal direction. The capillary body 10 comprises a proximal
ring region and is occluded by a base at its distal end. In the
region of its ring body, the capillary body 10 is sealed
fluid-proof against the outer sleeve 3 and preferably also against
the inner sleeve 4b. A distal front area of the inner sleeve 4b
pushes fluid-proof against the base of the capillary body 10 via a
sealing ring 18. The capillary body 10 is provided with a aperture
opening 14 in the region of a distal opening on the front face of
the inner sleeve 4b which is sealed by the sealing ring 18.
[0031] An aperture open in one direction only is formed in the
capillary body 10 by a reflux valve. The reflux valve comprises a
valve ball 11 which is pressed into its fitting within the
capillary body 10 in a known way by means of a valve spring 12. The
valve spring 12 is in turn supported on a valve closure 13.
[0032] A fluid space is formed between the distal front area of the
drive piston 5 and a distal front area of the driven piston 6, said
fluid space being occluded fluid-proof by said two pistons 5 and 6
and comprising a first partial space 21 and a second partial space
22. The two partial spaces 21 and 22 are separated from each other
by the capillary body 10. The fluid space 21, 22 is completely
filled with an incompressible working fluid. A highly viscous oil
is preferably used as the working fluid.
[0033] The reflux valve 11, 12, 13 only allows a through-flow of
the working fluid from the partial space 22 into the partial space
21, and prevents a through-flow in the other direction.
[0034] The capillary body 10, together with an inner surface area
of the outer sleeve 3 surrounding the capillary body, forms a fluid
connection in the form of a system of capillaries. The system of
capillaries is shown in Detail I of FIG. 2. It is formed by a
single, connected fluid channel, namely a capillary 23. The
capillary 23, in the form of a multiple thread, encircles the outer
surface area of the capillary body 10 in a spiral. In principle,
the capillary 23 can also be formed by a single thread. When the
capillary body 10 is installed, the capillary 23 connects the two
partial fluid spaces 21 and 22. The inner surface area of the outer
sleeve 3 opposite the capillary 23 is simply smooth. The capillary
body 10 is guided into the outer sleeve 3 by a slight pressing
power. When installed, the "teeth" on the outer surface area of the
capillary body 10, which separate the individual threads of the
capillary 23 from each other, press fluid-proof against the inner
surface area of the outer sleeve 3. The teeth of the capillary body
10 are flattened for sealing purposes. The capillary body 10
consists of a softer material than the outer sleeve 3, in order to
improve sealing. For the same purpose, however, the outer sleeve 3
could also in principle be made of a softer material than the
capillary body 10.
[0035] An alternative embodiment of a capillary 23 is shown in FIG.
3. In this case, the capillary 23 is formed in one insert as a
straight fluid channel. The insert is held fluid-proof in a
receptacle of the capillary body. A bore which extends the
capillary 23 of the insert is formed in the capillary body 10, such
that in this embodiment too, a fluid connection is provided between
the two partial spaces 21 and 22 by means of a capillary 23.
[0036] By inserting a distance ring 9a, all deviations from the
corresponding desired values arising in the transmission link from
the pressure spring 8 to the driven piston 6 can be simply
compensated for. In this way, not only differences in the pressure
springs but also for example capillary defects may be compensated
for by means of the distance ring 9a. Compensating is achieved by
setting the bias of the pressure spring 8 by means of an easily
replaceable distance ring 9a. There are thus distance rings 9a of
various strengths for various types of devices, and when the device
is being assembled, the distance ring which exhibits the optimal
strength for compensating is inserted.
[0037] The functionality of the infusion device will now be
described:
[0038] In the state shown in FIG. 1, the container 1 is filled with
the product and the delivering piston 2 correspondingly assumes its
distal position in the container 1. The driven piston 6 also
correspondingly assumes its distal position in the inner sleeve 4b.
In this distal position, the driven piston 6 is ideally occluded by
the rear front area of the inner sleeve 4b, in order to keep the
overall length of the device as short as possible.
[0039] In this state of the device, the partial fluid space 22
exhibits its smallest volume. The partial fluid space 23
correspondingly exhibits its largest volume. The driven piston 6 is
held in its distal position either directly by the user or
preferably by means of a latch. At the same time, the drive piston
5 assumes its proximal position. In this proximal position of the
drive piston 5, the pressure spring 8 is tensed between the two
areas formed by the collar area of the drive piston 5 and the
distance ring 9a.
[0040] For subcutaneously administering the product, an injection
needle arranged at the proximal end of the catheter 20 is inserted,
and the latch on the driven piston 6 or the piston rod 7
respectively is released. Under the pressure of the pressure spring
8, a fluid pressure is built up in the partial fluid space 21 via
the drive piston 5. This fluid pressure can only be decreased by
the capillary 23. Under the pressure of the drive piston 5, fluid
flows out of the partial fluid space 21, through the capillary 23,
into the partial fluid space 22. The driven piston 6 is moved in
the proximal direction by the pressure building in the partial
fluid space 22. The partial fluid space 21 thus forms a drive side
and the partial fluid space 22 a driven side of the fluid space 21,
22 as a whole. More precisely, the drive side is formed by a piston
area of the drive piston 5 facing the partial fluid space 21, and
the drive side by a piston area of the driven piston 6 facing the
partial fluid space 22.
[0041] In the example embodiment, a pressure reducing means is
formed by the capillary body 10, the outer sleeve 3 and the
capillary 23 formed by their co-operation. A constructively
determined drop in pressure is effected by said pressure reducing
means. Due to the drop in pressure generated, it is possible to use
a stronger pressure spring 8 for driving the delivering piston 2
than would be possible in an unchoked drive.
[0042] Moreover, the piston area of the drive piston 5 is larger
than the piston area of the driven piston 6. Correspondingly, a
stroke of the drive piston 5 effects a comparatively greater stroke
of the driven piston 6. The driven piston 6 in turn acts directly
on the delivering piston 2 by means of the rigid piston rod 7.
Correspondingly, a complete stroke of the driven piston 6
corresponds to the stroke of the delivering piston 2. The stroke of
the delivering piston 2 is in turn determined by the conventionally
used containers 1. The complete working stroke of the delivering
piston 2, which corresponds to a complete delivery of the contents
of the container 1, compares with a by comparison substantially
shorter working stroke of the drive piston 5 and thus of the
pressure spring 8.
[0043] The concentric arrangement of the two partial fluid spaces
21 and 22 of the overall fluid space 21, 22 is also constructively
interesting. Through this arrangement, the overall length of the
device can be kept short.
[0044] To drive it, the delivering piston 2 is charged with a
pressure of about one bar, i.e. it exerts such a pressure on the
contents of the container 1. The fluid coupling is correspondingly
formed to transmit the force of the pressure spring 8 from the
drive side of the fluid space 21, 22 onto the driven side. This is
substantially achieved by the pressure reducing means formed by the
outer sleeve 3, the capillary body 10 and the capillary 23, and by
the size ratio of the two piston areas of the pistons 5 and 6.
[0045] After the product has been delivered, for example after the
device has been completely emptied, the container 1 can be
re-filled to administer product again, or preferably replaced with
a new, filled container. Before replacing the container, the
delivering piston 2 is retracted by means of the piston rod 7 to
the starting position shown in FIG. 1. In the starting position,
the piston rod 7 is latched by a suitable locking means. In the
course of retracting, the driven piston 6 pushes the fluid out of
the completely filled partial fluid space 22 into the partial fluid
space 21. In this way, the fluid flows out of the internal space of
the inner sleeve 4b, through the opening 14 in the base of the
capillary body 10, and via a small intermediate space between the
sealing cap 19 and the capillary body 10 to the reflux valve 11,
12, 13. Under the pressure of the fluid in the partial fluid space
22, the reflux valve opens and the fluid flows through the
through-flow formed by the reflux valve and into the partial fluid
space 21. Here, the pressure of the pressure spring 8 has to be
overcome to advance the drive piston 5 in the proximal direction
and ultimately into the starting position shown. The device is then
ready to deliver product again.
[0046] In the foregoing description a preferred embodiment of the
invention has been presented for the purpose of illustration and
description. It is not intended to be exhaustive or to limit the
invention to the precise form disclosed. Obvious modifications or
variations are possible in light of the above teachings. The
embodiment was chosen and described to provide the best
illustration of the principals of the invention and its practical
application, and to enable one ordinary skill in the art to utilize
the invention in various embodiments and with various modifications
as are suited to the particular use contemplated. All such
modifications and variations are within the scope of the invention
as determined by the appended claims when interpreted in accordance
with the breadth they are fairly, legally, and equitably
entitled.
List of Reference Numerals
[0047] 1 container, ampoule
[0048] 2 delivering means, delivering piston
[0049] 3 casing, outer sleeve
[0050] 4a container holder
[0051] 4b inner sleeve
[0052] 5 drive piston
[0053] 6 driven piston
[0054] 7 piston rod
[0055] 8 drive means, drive spring, pressure spring
[0056] 9 sealing cap
[0057] 9a distance piece
[0058] 10 separating body, capillary body
[0059] 11 valve ball
[0060] 12 valve spring
[0061] 13 valve closure
[0062] 14 aperture opening
[0063] 15 sealing rings
[0064] 16 sealing rings
[0065] 17 sealing rings
[0066] 18 sealing ring
[0067] 19 sealing cap
[0068] 20 catheter
[0069] 21 partial fluid space
[0070] 22 partial fluid space
[0071] 23 fluid connection, system of capillaries, fluid channel,
capillary
* * * * *