U.S. patent application number 10/687109 was filed with the patent office on 2004-03-18 for three dimensional structures and models of fc receptors and uses thereof.
This patent application is currently assigned to Ilexus Pty Limited. Invention is credited to Epa, Vidana, Garrett, Thomas P.J., Hogarth, P. Mark, Maxwell, Kelly F., McKenzie, Ian F.C., Powell, Maree S..
Application Number | 20040054480 10/687109 |
Document ID | / |
Family ID | 26755120 |
Filed Date | 2004-03-18 |
United States Patent
Application |
20040054480 |
Kind Code |
A1 |
Hogarth, P. Mark ; et
al. |
March 18, 2004 |
Three dimensional structures and models of Fc receptors and uses
thereof
Abstract
Disclosed are crystals, crystal structure Fc.gamma.RIIa protein,
three dimensional coordinates of Fc.gamma.RIIa protein, and
structures and models derived from the Fc.gamma.RIIa structure.
Also disclosed are crystals of Fc.epsilon.RI protein and three
dimensional coordinates of Fc.epsilon.RI protein monomers and
dimers derived from the Fc.gamma.RIIa structure. Also disclosed are
three dimensional coordinates of Fc.gamma.RIIIb proteins and models
of Fc.gamma.RIIIb derived from the Fc.gamma.RIIa structure. The
present invention also includes methods to produce such crystals,
crystal structures and models. Uses of such crystals, crystal
structures and models are also disclosed, including structure based
drug design and therapeutic compositions.
Inventors: |
Hogarth, P. Mark;
(Williamstown, AU) ; Powell, Maree S.; (Ferntree
Gully, AU) ; McKenzie, Ian F.C.; (Brunswick, AU)
; Maxwell, Kelly F.; (South Yarra, AU) ; Garrett,
Thomas P.J.; (Brunswick, AU) ; Epa, Vidana;
(Parkville, AU) |
Correspondence
Address: |
SHERIDAN ROSS PC
1560 BROADWAY
SUITE 1200
DENVER
CO
80202
|
Assignee: |
Ilexus Pty Limited
|
Family ID: |
26755120 |
Appl. No.: |
10/687109 |
Filed: |
October 15, 2003 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
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10687109 |
Oct 15, 2003 |
|
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|
09245764 |
Feb 5, 1999 |
|
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6675105 |
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60073972 |
Feb 6, 1998 |
|
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60099994 |
Sep 11, 1998 |
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Current U.S.
Class: |
702/19 ; 702/27;
703/11 |
Current CPC
Class: |
C12N 2799/026 20130101;
C07K 14/70535 20130101; Y02A 90/10 20180101; A61P 43/00 20180101;
A61P 29/00 20180101; A61K 38/00 20130101; C07K 2299/00 20130101;
A61P 37/02 20180101 |
Class at
Publication: |
702/019 ;
702/027; 703/011 |
International
Class: |
G06F 019/00; G01N
033/48; G06G 007/48 |
Claims
What is claimed is:
1. A model of an Fc receptor (FcR) protein, wherein said model
represents a three dimensional structure that substantially
conforms to the atomic coordinates of Table 1.
2. The model of claim 1, wherein said structure substantially
conforms to the atomic coordinates and B-values represented by
Table 1.
3. The model of claim 1, wherein said structure is monomeric.
4. The model of claim 1, wherein said structure is dimeric.
5. The model of claim 1, wherein said structure substantially
conforms to the atomic coordinates of a table selected from the
group consisting of Table 2, Table 3, Table 4 and Table 5.
6. The model of claim 1, wherein at least about 50% of said
structure has an average root-mean-square deviation (RMSD) of less
than about 1.5 .ANG. for backbone atoms in secondary structure
elements in each domain of said structure.
7. The model of claim 1, wherein at least about 50% of common amino
acid side chains between said structure and a structure comprising
said atomic coordinates have an average root-mean-square deviation
(RMSD) of less than about 1.5 .ANG..
8. The model of claim 1, wherein said FcR protein comprises an
amino acid sequence that is at least about 25% identical to an
amino acid sequence selected from the group consisting of SEQ ID
NO:3, SEQ ID NO:10, SEQ ID NO:11 and SEQ 5 ID NO:12.
9. The model of claim 1, wherein said FcR protein comprises an
amino acid sequence that is at least about 40% identical to an
amino acid sequence selected from the group consisting of SEQ ID
NO:3, SEQ ID NO:10, SEQ ID NO:11 and SEQ ID NO:12.
10. The model of claim 1, wherein said FcR protein comprises an
amino acid sequence that is at least about 60% identical to an
amino acid sequence selected from the group consisting of SEQ ID
NO:3, SEQ ID NO:10, SEQ ID NO:11 and SEQ ID NO:12.
11. The model of claim 1, wherein said FcR protein comprises an
amino acid sequence selected from the group consisting of: SEQ ID
NO:3, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID
NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13, a
mutant of any of said amino acid sequences, and an allelic variant
of any of said amino acid sequences.
12. The model of claim 1, wherein said FcR protein comprises an
amino acid sequence selected from the group consisting of: an amino
acid sequence selected from the group consisting of SEQ ID NO:3,
SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9,
SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, SEQ ID NO:13; a mutant of
SEQ ID NO:3, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8,
SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12 or SEQ ID
NO:13; and an allelic variant of SEQ ID NO:3, SEQ ID NO:5, SEQ ID
NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID
NO:11, SEQ ID NO:12 or SEQ ID NO:13.
13. The model of claim 1, wherein said FcR protein is selected from
the group consisting of Fc.gamma.RI protein, Fc.gamma.RIIa protein,
Fc.gamma.RIIb protein, Fc.gamma.RIIc protein, Fc.gamma.RIII
protein, Fc.epsilon.RI protein, Fc.alpha.RI protein and structural
homologues of any of said FcR proteins.
14. The model of claim 1, wherein said FcR protein is selected from
the group consisting of Fc.gamma.RI protein, Fc.gamma.RIIa protein,
Fc.gamma.RIIb protein, Fc.gamma.RIIc protein, Fc.gamma.RIII
protein, Fc.epsilon.RI protein and Fc.alpha.RI protein.
15. The model of claim 1, wherein said FcR protein is selected from
the group consisting of an Fc.gamma.RIIa protein monomer, an
Fc.gamma.RIIa protein dimer and structural homologues of said
Fc.gamma.RIIa proteins.
16. The model of claim 1, wherein said FcR protein is selected from
the group consisting of an Fc.epsilon.RI protein dimer, an
Fc.epsilon.RI protein monomer and structural homologues of said
Fc.epsilon.RI proteins.
17. The model of claim 1, wherein said FcR protein is selected from
the group consisting of an Fc.gamma.RI protein dimer, an
Fc.gamma.RI protein monomer and structural homologues of said
Fc.gamma.RI protein.
18. The model of claim 1, wherein said FcR protein is selected from
the group consisting of an Fc.gamma.RIIb protein dimer, an
Fc.gamma.RIIb protein monomer and structural homologues of said
Fc.gamma.RIIb protein.
19. The model of claim 1, wherein said FcR protein is selected from
the group consisting of an Fc.gamma.RIIc protein dimer,
an.Fc.gamma.RIIc protein monomer and structural homologues of said
Fc.gamma.RIIc protein.
20. The model of claim 1, wherein said FcR protein is selected from
the group consisting of an Fc.gamma.RIIIb protein dimer, an
Fc.gamma.RIIIb protein monomer and structural homologues of said
Fc.gamma.RIIIb protein.
21. The model of claim 1, wherein said FcR protein is selected from
the group consisting of an Fc.alpha.RI protein dimer, an
Fc.alpha.RI protein monomer and structural homologues of said
Fc.alpha.RI protein.
22. The model of claim 1, wherein said atomic coordinates are
generated by the method comprising: (a) providing an Fc.gamma.RIIa
protein in crystalline form; (b) generating an electron-density map
of said crystalline Fc.gamma.RIIa protein; and (c) analyzing said
electron-density map to produce said atomic coordinates.
23. The model of claim 22, wherein said crystalline Fc.gamma.RIIa
protein is produced by a method comprising: combining Fc.gamma.RIIa
protein with a mother liquor buffer selected from the group
consisting of an acetate salt buffer and a sulphate buffer, and
inducing crystal formation to produce said crystalline
Fc.gamma.RIIa protein.
24. The model of claim 23, wherein said acetate buffer comprises
about 200 mM ammonium acetate, about 100 mM sodium citrate and
about 30% PEG 4000, said buffer having a pH of about 5.6.
25. The model of claim 23, wherein said sulphate buffer comprises
about 0.1 M HEPES and about 1.5 M lithium sulphate, said buffer
having a pH of about 7.5.
26. The model of claim 22, wherein said step of generating an
electron-density map comprises analyzing said crystalline
Fc.gamma.RIIa protein by X-ray diffraction.
27. The model of claim 22, wherein said crystalline Fc.gamma.RIIa
protein is derivatized in Di-.gamma.-iodo bis{ethylenediamine} di
Platinum(II) nitrate prior to said X-ray diffraction.
28. The model of claim 22, wherein said crystalline Fc.gamma.RIIa
protein is derivatized in about 5 mM Di-.gamma.-iodo
bis[ethylenediamine] di Platinum(II) nitrate prior to said X-ray
diffraction.
29. The model of claim 1, wherein said model is a computer image
generated by a computer-readable medium encoded with a set of three
dimensional coordinates of said three dimensional structure,
wherein, using a graphical display software program, said three
dimensional coordinates create an electronic file that can be
visualized on a computer capable of representing said electronic
file as a three dimensional image.
30. A computer-assisted method of structure based drug design of
bioactive compounds, comprising: a. providing a model of an Fc
receptor (FcR) protein, wherein said model represents a three
dimensional structure that substantially conforms to the atomic
coordinates of Table 1; b. designing a chemical compound using said
model; and, c. chemically synthesizing said chemical compound.
31. The method of claim 30, wherein said method further comprises:
d. evaluating the bioactivity of said synthesized chemical
compound.
32. The method of claim 30, wherein said three dimensional
structure comprises the atomic coordinates listed in Table 1.
33. The method of claim 30, wherein said three dimensional
structure is dimeric.
34. The method of claim 30, wherein said three dimensional
structure comprises the atomic coordinates listed in a table
selected from the group consisting of Table 2, Table 3, Table 4,
and Table 5.
35. The method of claim 30, wherein said model comprises a computer
image generated when the atomic coordinates listed in Table 1 are
analyzed on a computer using a graphical display software program
to create an electronic file of said image and visualizing said
electronic file on a computer capable of representing said
electronic file as a three dimensional image.
36. The method of claim 30, wherein said step of designing
comprises computational screening of one or more databases of
chemical compounds in which the three dimensional structure of said
compounds are known.
37. The method of claim 36, further comprising interacting a
compound identified by said screening step with said model by
computer.
38. The method of claim 30, wherein said step of designing
comprises directed drug design.
39. The method of claim 30, wherein said step of designing
comprises random drug design.
40. The method of claim 30, wherein said step of designing
comprises grid-based drug design.
41. The method of claim 30, wherein said step of designing
comprises selecting compounds which are predicted to mimic said
three dimensional structure of said FcR protein.
42. The method of claim 30, wherein said step of designing
comprises selecting compounds which are predicted to bind to said
three dimensional structure of said FcR protein.
43. The method of claim 30, wherein said bioactivity is selected
from the group consisting of inhibiting binding of said FcR protein
to an immunoglobulin protein, binding to said FcR protein, binding
to an immunoglobulin which is capable of binding to said FcR
protein, inhibiting phagocytosis of said immunoglobulin protein,
inhibiting dimerization of said FcR protein, stimulating cellular
signal transduction though said FcR protein, and stimulating
release of cytokines through said FcR protein.
44. The method of claim 30, wherein said FcR protein is
Fc.gamma.RIIa and said bioactivity is selected from the group
consisting of inhibiting binding of Fc.gamma.RIIa protein to IgG,
inhibiting phagocytosis of IgG, inhibiting dimerzation of
Fc.gamma.RIIa protein, stimulating cellular signal transduction
though an Fc.gamma.RIIa protein, stimulating release of cytokines
selected from the group consisting of IL-6 and IL-12.
45. The method of claim 30, wherein said FcR protein is
Fc.gamma.RIIIb and said bioactivity is selected from the group
consisting of inhibiting binding of Fc.gamma.RIIIb protein to IgG,
inhibiting phagocytosis of IgG, inhibiting dimerzation of
Fc.gamma.RIIIb protein, stimulating cellular signal transduction
though an Fc.gamma.RIIIb protein, stimulating release of cytokines
selected from the group consisting of IL-6 and IL-12.
46. The method of claim 30, wherein said FcR protein is
Fc.epsilon.RI and said bioactivity is selected from the group
consisting of inhibiting binding of Fc.epsilon.RI protein to IgE,
inhibiting phagocytosis of IgE, inhibiting dimerzation of
Fc.epsilon.RI protein, stimulating cellular signal transduction
though an Fc.epsilon.RI protein, stimulating release of histamine
and serotonin by mast cells and inhibiting release of histamine and
serotonin by mast cells.
47. A computer-assisted method of structure based drug design of
bioactive compounds, comprising: a. providing a model of an Fc
receptor (FcR) protein, wherein said model represents a three
dimensional structure that substantially conforms to the atomic
coordinates selected from the group consisting of atomic
coordinates represented by Table 1; atomic coordinates represented
by Table 2; atomic coordinates represented by Table 3; atomic
coordinates represented by Table 4; and atomic coordinates
represented by Table 5; b. designing a chemical compound using said
model; and, c. chemically synthesizing said chemical compound.
48. A computer-assisted method of structure based drug design of
bioactive compounds, comprising: a. providing a model of a three
dimensional structure of an Fc receptor (FcR) protein selected from
the group consisting of Fc.gamma.RIIa, Fc.gamma.RIIIb and
Fc.epsilon.RI; b. designing a chemical compound using said model;
and, c. chemically synthesizing said chemical compound.
49. A three dimensional computer image of the three dimensional
structure of an FcR protein.
50. The image of claim 49, wherein said structure substantially
conforms with the three dimensional coordinates selected from the
group consisting of the three dimensional coordinates listed in
Table 1; the three dimensional 5 coordinates listed in Table 2; the
three dimensional coordinates listed in Table 3; the three
dimensional coordinates listed in Table 4; and the three
dimensional coordinates listed in Table 5.
51. The image of claim 49, wherein said computer image is generated
when a set of three dimensional coordinates comprising said three
dimensional coordinates are analyzed on a computer using a
graphical display software program to 5 create an electronic file
of said image and visualizing said electronic file on a computer
capable of representing electronic file as a three dimensional
image.
52. The image of claim 49, wherein said three dimensional computer
image is represented by a two dimensional image selected from the
group consisting of FIG. 4, FIG. 6, FIG. 7, FIG. 8, FIG. 9, FIG.
10, FIG. 14, FIG. 15 and FIG. 16.
53. The image of claim 49, wherein said three dimensional computer
image is used to design a therapeutic compound.
54. A computer-readable medium encoded with a set of three
dimensional coordinates of an FcR protein having a three
dimensional structure that substantially conforms to the atomic
coordinates of Table 1, wherein, using a graphical display software
program, said three dimensional coordinates create an electronic
file that can be visualized on a computer capable of representing
said electronic file as a three dimensional image.
55. A computer-readable medium encoded with a set of three
dimensional coordinates selected from the group consisting of the
three dimensional coordinates represented in Table 1, the three
dimensional coordinates represented in Table 2, the three
dimensional coordinates represented in Table 3, the three
dimensional coordinates represented in Table 4, and the three
dimensional coordinates represented in Table 5, wherein, using a
graphical display software program, said three dimensional
coordinates create an electronic file that can be visualized on a
computer capable of representing said electronic file as a three
dimensional image.
56. A model of the three dimensional structure of an FcR protein
selected from the group consisting of Fc.gamma.RI protein,
Fc.gamma.RIIb protein, Fc.gamma.RIIc protein, Fc.gamma.RIIIb
protein, Fc.epsilon.RI protein and Fc.epsilon.RI protein, said
model being produced by the method comprising: (a) providing an
amino acid sequence of an Fc.gamma.RIIa protein and an amino acid
sequence of said FcR protein; (b) identifying structurally
conserved regions shared between said Fc.gamma.RIIa amino acid
sequence and said FcR protein amino acid sequence; and (c)
determining atomic coordinates for said FcR protein by assigning
said structurally conserved regions of said FcR protein to a three
dimensional structure using a three dimensional structure of said
Fc.gamma.RIIa protein which substantially conforms to the atomic
coordinates represented in Table 1, to derive a model of said three
dimensional structure of said FcR protein amino acid sequence.
57. The model of claim 56, wherein said Fc.gamma.RI protein amino
acid sequence comprises SEQ ID NO:7; wherein said Fc.gamma.RIIb
protein amino acid sequence comprises SEQ ID NO:5; wherein said
Fc.gamma.RIIc protein amino acid sequence comprises SEQ ID NO:6;
wherein said Fc.gamma.RIIIb protein amino acid sequence comprises
SEQ ID NO:8; wherein said Fc.epsilon.RI protein amino acid sequence
comprises SEQ ID NO:9; and wherein said Fc.alpha.RI protein amino
acid sequence comprises SEQ ID NO:13.
58. A therapeutic composition that, when administered to an animal,
reduces IgG-mediated tissue damage, said therapeutic composition
comprising an inhibitory compound that inhibits the activity of an
Fc.gamma. receptor (Fc.gamma.R) protein, said inhibitory compound
being identified by the method comprising: (a) providing a three
dimensional structure of an Fc.gamma.R protein selected from the
group consisting of Fc.gamma.RI, Fc.gamma.RIIa, Fc.gamma.RIIb,
Fc.gamma.RIIc and Fc.gamma.RIIIb, wherein said three dimensional
structure of said Fc.gamma.R protein substantially conforms to
atomic coordinates represented by Table 1; (b) using said three
dimensional structure of said Fc.gamma.R protein to design a
chemical compound selected from the group consisting of a compound
that inhibits binding of Fc.gamma.R protein to IgG, a compound that
substantially mimics the three dimensional structure of Fc.gamma.R
protein and a compound that inhibits binding of Fc.gamma.R protein
with a molecule that stimulates cellular signal transduction
through an Fc.gamma.R protein; (c) chemically synthesizing said
chemical compound; and (d) evaluating the ability of said
synthesized chemical compound to reduce IgG-mediated tissue
damage.
59. The composition of claim 58, wherein said IgG-mediated tissue
damage results from a biological response selected from the group
consisting of IgG-mediated hypersensitivity, IgG-mediated
recruitment of inflammatory cells, and IgG-mediated release of
inflammatory modulators.
60. The composition of claim 58, wherein said structure
substantially conforms with the atomic coordinates represented in
Table 1.
61. The composition of claim 58, wherein said chemical compound is
selected from the group consisting of an inorganic compound and an
organic compound.
62. The composition of claim 58, wherein said chemical compound is
selected from the group consisting of oligonucleotides, peptides,
peptidomimetic compounds and small organic molecules.
63. The composition of claim 58, wherein said chemical compound is
selected from the group consisting of an analog of said Fc.gamma.R
protein, a substrate analog of said Fc.gamma.R protein and a
peptidomimetic compound of said Fc.gamma.R protein.
64. The composition of claim 58, wherein said composition further
comprises a component selected from the group consisting of an
excipient, an adjuvant, and a carrier.
65. A therapeutic composition that, when administered to an animal,
enhances IgG-mediated responses, said therapeutic composition
comprising a stimulatory compound that stimulates the activity of
an Fc.gamma. receptor (Fc.gamma.R) protein, said stimulatory
compound being identified by the method comprising: (a) providing a
three dimensional structure of an Fc.gamma.R protein selected from
the group consisting of Fc.gamma.RI, Fc.gamma.RIIa, Fc.gamma.RIIb,
Fc.gamma.RIIc and Fc.gamma.RIIIb, wherein said three dimensional
structure of said Fc.gamma.R protein substantially conforms to
atomic coordinates represented by Table 1; (b) using said three
dimensional structure of said Fc.gamma.R protein to design a
chemical compound selected from the group consisting of a compound
that stimulates binding of Fc.gamma.R protein to IgG, a compound
that substantially mimics the three dimensional structure of
Fc.gamma.R protein and a compound that stimulates binding of
Fc.gamma.R protein with a molecule that stimulates cellular signal
transduction through an Fc.gamma.R protein; (c) chemically
synthesizing said chemical compound; and (d) evaluating the ability
of said synthesized chemical compound to enhance IgG-mediated
responses.
66. A therapeutic composition that, when administered to an animal,
reduces IgE-mediated responses, said therapeutic composition
comprising an inhibitory compound that inhibits the activity of an
Fc.epsilon. receptor I (Fc.epsilon.RI) protein, said inhibitory
compound being identified by the method comprising: (a) providing a
three dimensional structure of an Fc.epsilon.RI protein, wherein
said three dimensional structure of said Fc.epsilon.RI protein
substantially conforms to the atomic coordinates selected from the
group consisting of the atomic coordinates represented by Table 1,
the atomic coordinates represented by Table 2, the atomic
coordinates represented by Table 3, the atomic coordinates
represented by Table 4 and the atomic coordinates represented by
Table 5; (b) using said three dimensional structure of said
Fc.epsilon.RI protein to design a chemical compound selected from
the group consisting of a compound that inhibits binding of
Fc.epsilon.RI protein to IgE, a compound that substantially mimics
the three dimensional structure of Fc.epsilon.RI protein and a
compound that inhibits binding of Fc.epsilon.RI protein with a
molecule that stimulates cellular signal transduction through an
Fc.epsilon.RI protein; (c) chemically synthesizing said chemical
compound; and (d) evaluating the ability of said synthesized
chemical compound to reduce IgE-mediated responses.
67. The composition of claim 66, wherein said IgE-mediated response
results from a biological response selected from the group
consisting of IgE-mediated hypersensitivity, IgE-mediated
recruitment of inflammatory cells, and IgE-mediated release of
inflammatory modulators.
68. The composition of claim 66, wherein said structure comprises
the atomic coordinates represented in Table 3.
69. The composition of claim 66, wherein said structure comprises
the atomic coordinates represented in Table 4.
70. The composition of claim 66, wherein said chemical compound is
selected from the group consisting of an inorganic compound and an
organic compound.
71. The composition of claim 66, wherein said chemical compound is
selected from the group consisting of oligonucleotides, peptides,
peptidomimetic compounds and small organic molecules.
72. The composition of claim 66, wherein said chemical compound is
selected from the group consisting of an analog of said
Fc.epsilon.R protein, a substrate analog of said Fc.epsilon.RI
protein and a peptidomimetic compound of said Fc.epsilon.RI
protein.
73. The composition of claim 66, wherein said composition further
comprises a component selected from the group consisting of an
excipient, an adjuvant, and a carrier.
74. A therapeutic composition that, when administered to an animal,
enhances IgE-mediated responses, said therapeutic composition
comprising a stimulatory compound that stimulates the activity of
an Fc.epsilon. receptor I (Fc.epsilon.RI) protein, said stimulatory
compound being identified by the method comprising: (a) providing a
three dimensional structure of an Fc.epsilon.RI protein, wherein
said three dimensional structure of said Fc.epsilon.RI protein
substantially conforms to the atomic coordinates selected from the
group consisting of the atomic coordinates represented by Table 1,
the atomic coordinates represented by Table 2, the atomic
coordinates represented by Table 3, the atomic coordinates
represented by Table 4 and the atomic coordinates represented by
Table 5; (b) using said three dimensional structure of said
Fc.epsilon.RI protein to design a chemical compound selected from
the group consisting of a compound that stimulates binding of
Fc.epsilon.RI protein to IgE, a compound that substantially mimics
the three dimensional structure of Fc.epsilon.RI protein and a
compound that stimulates binding of Fc.epsilon.RI protein with a
molecule that stimulates cellular signal transduction through an
Fc.epsilon.RI protein; (c) chemically synthesizing said chemical
compound; and (d) evaluating the ability of said synthesized
chemical compound to enhance IgE-mediated responses.
75. A method to determine a three dimensional structure of an FcR
protein, said method comprising (a) providing an amino acid
sequence of an FcR protein selected from the group consisting of
Fc.gamma.RI protein, Fc.gamma.RIIb protein, Fc.gamma.RIIc protein,
Fc.gamma.RIIIb protein, Fc.epsilon.RI protein and Fc.alpha.RI
protein, wherein the three dimensional structure of said FcR
protein is not known; (b) analyzing the pattern of folding of said
amino acid sequence in a three dimensional conformation by fold
recognition; and (c) comparing said pattern of folding of said FcR
protein amino acid sequence with the three dimensional structure of
Fc.gamma.RIIa protein to determine the three dimensional structure
of said FcR protein, wherein said three dimensional structure of
said Fc.gamma.RIIa protein substantially conforms to the atomic
coordinates represented in Table 1.
76. A method to derive a model of the three dimensional structure
of an FcR protein, said method comprising the steps of: (a)
providing an amino acid sequence of an Fc.gamma.RIIa protein and an
amino acid sequence of an FcR protein; (b) identifying structurally
conserved regions shared between said Fc.gamma.RIIa amino acid
sequence and said FcR protein amino acid sequence; (c) determining
atomic coordinates for said target structure by assigning said
structurally conserved regions of said FcR protein to a three
dimensional structure using a three dimensional structure of an
Fc.gamma.RIIa protein based on atomic coordinates that
substantially conform to the atomic coordinates represented in
Table 1 to derive a model of the three dimensional structure of
said FcR protein amino acid sequence.
77. The method of claim 76, further comprising assigning atomic
coordinates for side chains of said FcR protein by determining
sterically allowable positions using a library of rotamers.
78. A method to derive a three dimensional structure of a
crystallized FcR protein, said method comprising the steps of: (a)
comparing the Patterson function of a crystallized FcR protein with
the Patterson function of crystalline Fc.gamma.RIIa protein to
produce an electron-density map of said crystallized FcR protein;
and (b) analyzing said electron-density map to produce said three
dimensional structure of said crystallized FcR protein.
79. The method of claim 78, further comprising the step of
electronically simulating said three dimensional structure of said
crystallized FcR protein to derive a computer image of said three
dimensional structure of said crystallized FcR protein.
80. The method of claim 78, further comprising the step of rotating
said Patterson function of said crystallized FcR protein on said
Patterson function of said crystalline Fc.gamma.RIIa protein to
determine the correct orientation of said crystallized FcR protein
in a crystal of said crystallized FcR protein to identify the
initial phases of said crystallized FcR protein.
81. A composition comprising Fc.gamma.RIIa protein in a crystalline
form.
Description
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This application claims priority under 35 U.S.C. .sctn.
119(e) from U.S. Provisional Application No. 60/073,972, filed Feb.
6, 1998, entitled "CRYSTALS, CRYSTAL STRUCTURES OF Fc.gamma.RIIa,
AND USES THEREOF". This application also claims priority under 35
U.S.C. .sctn. 119(e) from U.S. Provisional Application No.
60/099,994, filed Sep. 11, 1998, entitled "THREE DIMENSIONAL
STRUCTURES AND MODELS OF Fc RECEPTORS AND USES THEREOF." The entire
disclosure of each of U.S. Provisional Application Nos. 60/073,972
and 60/099,994 is incorporated herein by reference.
FIELD OF THE INVENTION
[0002] The present invention relates to three dimensional
structures of Fc receptors (FcR), including crystalline
Fc.gamma.RIIa, crystalline Fc.epsilon.RI, three dimensional
coordinates of Fc.gamma.RIIa protein, a three dimensional structure
of Fc.gamma.RIIa, three dimensional structures of FcR, and
particularly Fc.epsilon.RI and Fc.gamma.RIIIb, derived from the
structure of Fc.gamma.RIIa, models thereof, and uses of such
structures and models.
BACKGROUND OF THE INVENTION
[0003] Fc receptors (FcR) are a family of highly related receptors
that are specific for the Fc portion of immunoglobulin (Ig). These
receptors have major roles in normal immunity and resistance to
infection and provide the humoral immune system with a cellular
effector arm. Receptors have been defined for each of the
immunoglobulin classes and as such are defined by the class of Ig
of which they bind (i.e. Fc gamma receptor (Fc.gamma.R) bind gamma
immunoglobulin (IgG), Fc epsilon receptor (Fc.epsilon.R) bind
epsilon immunoglobulin (IgE), Fc alpha receptor (Fc.alpha.R) bind
alpha immunoglobulin (IgA)). Among the Fc.gamma.R receptors, three
subfamily members have been defined; Fc.gamma.RI, which is a high a
affinity receptor for IgG; Fc.gamma.RII, which are low affinity
receptors for IgG that avidly bind to aggregates immune complexes;
and Fc.gamma.RIII, which are low affinity receptors that bind to
immune complexes. These receptors are highly related structurally
but perform different functions. The structure and function of
Fc.gamma.RII is of interest because of its interaction with immune
complexes and its association with disease.
[0004] Fc.gamma.R are expressed on most hematopoietic cells, and
through the binding of IgG play a key role in homeostasis of the
immune system and host protection against infection. Fc.gamma.RII
is a low affinity receptor for IgG that essentially binds only to
IgG immune complexes and is expressed on a variety of cell types
including, for example monocytes, macrophages, neutrophils,
eosinophils, platelets and B lymphocytes. Fc.gamma.RII is involved
in various immune and inflammatory responses including
antibody-dependent cell-mediated cytotoxicity, clearance of immune
complexes, release of inflammatory mediators and regulation of
antibody production. The binding of IgG to an Fc.gamma.R can lead
to disease indications that involve regulation by Fc.gamma.R. For
example, the autoimmune disease thrombocytopenia purpura involves
tissue (platelet) damage resulting from Fc.gamma.R-dependent IgG
immune complex activation of platelets or their destruction by
Fc.gamma.R+phagocytes. In addition, various inflammatory disease
are known to involve IgG immune complexes (e.g. rheumatoid
arthritis, systemic lupus erythematosus), including type II and
type III hypersensitivity reactions. Type II and type III
hypersensitivity reactions are mediated by IgG, which can activate
either complement-mediated or phagocytic effector mechanisms,
leading to tissue damage.
[0005] The elucidation of the protein structure of Fc.gamma.RIIa,
Fc.epsilon.RI, or indeed any FcR is of importance in the
formulation of therapeutic and diagnostic reagents for disease
management. Until the discovery of the present invention, the
structure and resulting mechanism by which Fc.gamma.RIIa regulates
immune responses was unknown. Thus, despite the general
multifunctional role of Fc.gamma.RIIa, development of useful
reagents for treatment or diagnosis of disease was hindered by lack
of structural information of the receptor. The linear nucleic acid
and amino acid sequence of Fc.gamma.RIIa have been previously
reported (Hibbs et al. Proc. Natl. Acad. Sci. USA, vol. 85, pp.
2240-2244, 1988). Mutagenesis studies to identify regions of human
Fc.gamma.RIIa (Hulett et al., Eur. J. Immunol., vol. 23, pp.
40-645, 1993; Hulett et al., J. Biol. Chem., vol. 69, pp.
15287-15293 1994; and Hulett et al., J. Biol. Chem., vol. 270, pp.
21188-21194, 1995), human Fc.gamma.RIIIb (Hibbs et al., J.
Immunol., vol. 152, p. 4466, 1994; and Tamm et al., J. Biol. Chem.,
vol. 271, p. 3659, 1996) and mouse Fc.gamma.RI (Hulett et al., J.
Immunol., vol. 148, pp. 1863-1868, 1991) have defined important
regions of IgG binding to the Fc.gamma.R. Information based on
linear sequences, however, cannot accurately predict three
dimensional structure of the protein and its functional domains.
Huber et al. (J. Mol. Biol., vol. 230, pp. 1077-1083, 1993) have
described crystal formation of neonatal rat Fc receptor protein
(FcRn). Burmeister et al. (Nature, vol. 372, pp. 336-343, 1994; and
Nature, vol. 372, pp. 379-383, 1994) have described the structure
of FcRn crystals. FcRn, however, is closely related to major
histocompatability protein complex and not related to the leukocyte
Fc.gamma.R family by function or structure. Thus, the protein
structure of FcRn is not predictive of the FcR structure of the
present invention.
[0006] Fc.epsilon.R are expressed on mast cells, and through the
binding of IgE, trigger an inflammatory immune response which is
primarily due to the release of inflammatory mediators upon
degranulation of the mast cell (e.g., histamine and serotonin).
Release of these mediators causes localized vascular permeability
and increase in fluids in the local tissues, including an influx of
polymorphonuclear cells into the site. Thus, binding of IgE to an
Fc.epsilon.RI can lead to disease indications that involve
discharge of fluids from the gut and increased mucus secretion and
bronchial contraction, such indications typically being associated
with diseases involving allergic inflammation. Therefore, the
elucidation of protein structure of Fc.epsilon.RI is of importance
in the formulation of therapeutic and diagnostic reagents for
disease management, and in particular, for the management of
diseases related to allergic inflammation and other Th2-based
immune responses. As for the Fc.gamma.R described above, the linear
nucleic acid and amino acid sequences of human Fc.epsilon.RI have
been previously reported (Kochan et al., 1998, Nuc. Acid. Res.
16:3584). Until the discovery of the present invention, however,
the structure and resulting mechanism by which Fc.epsilon.R
regulates immune responses was unknown. Thus, despite the knowledge
of the general action of Fc.epsilon.RI, the development of useful
reagents for treatment or diagnosis of disease, such as diseases
associated with allergic inflammation, was hindered by lack of
structural information of the receptor.
[0007] Therefore, there is a need in the art to elucidate the three
dimensional structures and models of the Fc receptors, and to use
such structures and models in therapeutic strategies, such as drug
design.
SUMMARY OF THE INVENTION
[0008] The present invention relates to crystalline Fc.gamma.RIIa
and crystalline Fc.epsilon.RI, three dimensional coordinates of
Fc.gamma.RIIa protein, the three dimensional structure of
Fc.gamma.RIIa, three dimensional structures and models of Fc
receptors (FcR) derived from the structure of Fc.gamma.RIIa,
including Fc.epsilon.RI and Fc.gamma.RIIIb, and uses of such
structures and models. Obtaining such crystals is an unexpected
result. It is well known in the protein crystallographic art that
obtaining crystals of quality sufficient for determining the
structure of a protein is unpredictable. In particular, obtaining
crystals of quality sufficient for determining the three
dimensional (3-D) structure of Fc.gamma.RIIa has not been
achievable until the crystallization of Fc.gamma.RIIa as disclosed
in the present application. As such, determination of the three
dimensional structure of Fc.gamma.RIIa has not been possible until
the discovery of the present invention. Additionally, until the
discovery of the present invention, derivation of the three
dimensional structure and models of other Fc receptor (FcR)
proteins has not been possible. The present inventors are also the
first to define the three dimensional structure and provide three
dimensional models for drug design for Fc.epsilon.RI and
Fc.gamma.RIIIb.
[0009] Accordingly, one object of the present invention is to
provide crystals of sufficient quality to obtain a determination of
the three dimensional structure of Fc.gamma.RIIa to high
resolution, preferably to the resolution of about 1.8 angstrom. The
present invention also includes methods for producing crystalline
Fc.gamma.RIIa.
[0010] Yet another object of the present invention is to provide
crystals of Fc.epsilon.RI protein, preferably of sufficient quality
to obtain a determination of the three dimensional structure of
Fc.epsilon.RI to high resolution. The present invention also
includes methods for producing crystalline Fc.epsilon.RI.
[0011] The value of the crystals of Fc.gamma.RIIa and Fc.epsilon.RI
extends beyond merely being able to obtain such crystals. The
knowledge obtained concerning the Fc.gamma.RIIa crystal structure,
for example, has been used by the present inventors to define the
heretofore unknown tertiary structure of the Fc.gamma.RIIa protein,
to model and derive atomic coordinates for the heretofore unknown
tertiary structure of the Fc.epsilon.RI protein and the heretofore
unknown tertiary structure of the Fc.gamma.RIIIb protein, and can
be additionally used to model the heretofore unknown tertiary
structure of other FcR proteins having substantially related linear
amino acid sequence, such as for other members of the Fc.gamma.R
protein family and the Fc.alpha.RI protein. There are three members
of the Fc.gamma.R family of proteins, Fc.gamma.RI, Fc.gamma.RII and
Fc.gamma.RIII, all of which act as immunoregulatory molecules and
all of which bind to IgG. Comparison of nucleic acid and amino acid
sequences of the Fc.gamma.R family of receptors indicates that the
receptors are highly homologous. In addition, each member of the
Fc.gamma.R family of receptors belongs to the Ig super family of
molecules, an assignment based on well established criteria (Hulett
et al. 1994, ibid.). Moreover, Fc.gamma.RII, Fc.gamma.RIII,
Fc.epsilon.RI and Fc.alpha.RI each contain Ig-like domains,
indicating the similarity between these receptors. Fc.gamma.RI
contains three Ig-like domains. The first and second domains,
however, of Fc.gamma.RI are substantially homologous to the Ig-like
domains of Fc.gamma.RII, Fc.gamma.RIII, Fc.epsilon.RI and
Fc.alpha.RI. Current methods of tertiary structure determination
that do not rely on x-ray diffraction techniques and thus do not
require crystallization of the protein (e.g., computer modeling and
nuclear magnetic resonance techniques) enable derivation and
refinement of models of other Fc.gamma.R proteins, Fc.epsilon.RI
and Fc.alpha.RI protein, extrapolated from a three dimensional
structure of Fc.gamma.RIIa protein. Thus, knowledge of the three
dimensional structure of Fc.gamma.RIIa protein has provided a
starting point for investigation into the structure of all of these
proteins.
[0012] Accordingly, a second object of the present invention is to
provide information regarding the structure of Fc.gamma.RIIa
protein and models, atomic coordinates and derived three
dimensional structures of other members of the Fc.gamma.R family of
proteins, Fc.epsilon.RI and Fc.alpha.RI protein.
[0013] The knowledge of the three dimensional structure of
Fc.gamma.RIIa and models of other FcR provides a means for
designing and producing compounds that regulate immune function and
inflammation in an animal, including humans (i.e., structure based
drug design). For example, chemical compounds can be designed to
block binding of immunoglobulin to an Fc receptor protein using
various computer programs and models.
[0014] Another embodiment of the present invention is to provide a
three dimensional computer image of the three dimensional structure
of an FcR.
[0015] Another embodiment of the present invention is to provide a
computer-readable medium encoded with a set of three dimensional
coordinates selected from the group of the three dimensional
coordinates represented in Table 1, the three dimensional
coordinates represented in Table 2, the three dimensional
coordinates represented in Table 3, the three dimensional
coordinates represented in Table 4, and the three dimensional
coordinates represented in Table 5, wherein, using a graphical
display software program, the three dimensional coordinates create
an electronic file that can be visualized on a computer capable of
representing said electronic file as a three dimensional image.
[0016] Accordingly, a third object of the present invention is to
provide methods for using a three dimensional structure of FcR,
such as Fc.gamma.RIIa, and structures, coordinates and models
derived using such structure, for designing reagents for the
treatment and diagnosis of disease, such as by binding to or
mimicking the action of FcR protein, binding to or mimicking the
action of an immunoglobulin (Ig), disrupting cellular signal
transduction through an FcR protein by, for example, preventing
dimerization of two FcR proteins, or enhancing cellular signal
transduction or binding to an FcR by, for example, enhancing
dimerization of two FcR proteins.
[0017] The knowledge of the three dimensional structure of FcR also
provides a means for designing proteins that have altered
beneficial functions by analyzing the structure and interactions
between individual amino acids of the protein. For example,
therapeutic proteins having improved binding to Ig or immune
complexes of Ig can be designed to be used as therapeutic compounds
to prevent immune complex binding to cells or enhance biological
responses such as cellular signal transduction upon binding of FcR
to Ig or complexes thereof. Thus recombinant soluble FcR engineered
to contain improvements can be produced on the basis of the
knowledge of the three dimensional structure.
[0018] Accordingly, a fourth object of the present invention is to
provide for an extrapolation of the three dimensional structure of
FcR to create recombinant protein having altered biological
activity.
[0019] One embodiment of the present invention is a model of an FcR
protein, wherein the model represents the three dimensional
structure of FcR protein, in which the structure substantially
conforms to the atomic coordinates represented by Table 1. Other
embodiments of the present invention are the three dimensional
structure of an Fc.gamma.RIIa protein which substantially conforms
to the atomic coordinates represented by Table 1; the three
dimensional structure of a dimeric Fc.gamma.RIIa protein which
substantially conforms to the atomic coordinates represented by
Table 2; the three dimensional structure of a monomeric
Fc.epsilon.RI protein which substantially conforms to the atomic
coordinates represented by Table 3; the three dimensional structure
of a dimeric Fc.epsilon.RI protein which substantially conforms to
the atomic coordinates represented by Table 4; the three
dimensional structure of a dimeric Fc.gamma.RIIIb protein which
substantially conforms to the atomic coordinates represented by
Table 5 and models representing such structures. Further
embodiments of the present invention relate to a set of three
dimensional coordinates of an Fc.gamma.RIIa protein, wherein said
coordinates are represented in Table 1; a set of three dimensional
coordinates of a dimeric Fc.gamma.RIIa protein, wherein said
coordinates are represented in Table 2; a set of three dimensional
coordinates of an Fc.epsilon.RI protein, wherein said coordinates
are represented in Table 3; a set of three dimensional coordinates
of an Fc.epsilon.RI protein, wherein said coordinates are
represented in Table 4; and a set of three dimensional coordinates
of Fc.gamma.RIIIb, wherein said coordinates are represented in
Table 5. The present invention also includes methods to use such
structures including structure based drug design and methods to
derive models and images of target FcR structures.
[0020] Another embodiment of the present invention is a composition
comprising Fc.gamma.RIIa protein in a crystalline form. Yet another
embodiment of the present invention is a composition comprising
Fc.epsilon.RI protein in a crystalline form.
[0021] Yet another embodiment of the present invention is a method
for producing crystals of Fc.gamma.RIIa, comprising combining
Fc.gamma.RIIa protein with a mother liquor buffer selected from the
group consisting of an acetate salt buffer and a sulphate buffer,
and inducing crystal formation to produce said Fc.gamma.RIIa
crystals.
[0022] The present invention also includes a method for producing
crystals of Fc.epsilon.RI, comprising combining Fc.epsilon.RI
protein with a mother liquor buffer selected from the group
consisting of an acetate salt buffer, a sodium cacodylate buffer
and a sodium citrate buffer, and inducing crystal formation to
produce said Fc.epsilon.RI crystals.
[0023] The present invention also includes a therapeutic
composition that, when administered to an animal, reduces
IgG-mediated tissue damage, said therapeutic composition comprising
an inhibitory compound that inhibits the activity of an
Fc.gamma.RIIa protein, said inhibitory compound being identified by
the method comprising: (a) providing a three dimensional structure
of an Fc.gamma.RIIa protein; (b) using said three dimensional
structure to design a chemical compound selected from the group
consisting of a compound that inhibits binding of Fc.gamma.RIIa
protein to IgG, a compound that substantially mimics the three
dimensional structure of Fc.gamma.RIIa protein and a compound that
inhibits binding of Fc.gamma.RIIa protein with a molecule that
stimulates cellular signal transduction through an Fc.gamma.RIIa
protein; (c) chemically synthesizing said chemical compound; and
(d) evaluating the ability of said synthesized chemical compound to
reduce IgG-mediated tissue damage.
[0024] Another embodiment of the present invention is a therapeutic
composition that is capable of stimulating an IgG humoral immune
response in an animal. Yet another embodiment of the present
invention is a therapeutic composition that improves the
therapeutic affects of an antibody that is administered to an
animal to treat, by opsinization or Fc.gamma.R-dependent effector
functions (e.g. antibody-dependent Fc.gamma.R-medicated
cytotoxicity, phagocytosis or release of cellular mediators), a
particular disease, including, but not limited to, cancer or
infectious disease (e.g. oral infections such as HIV, herpes,
bacterial infections, yeast infections or parasite infections).
Such a therapeutic composition includes one or more stimulatory
compounds that have increased binding to IgG, enhance binding of
IgG to Fc.gamma.R, enhance dimer formation of an Fc.gamma.R and/or
enhance signal transduction through the Fc.gamma.R. Also included
in the present invention is a method to stimulate a humoral immune
response. The method includes the step of administering to an
animal a therapeutic composition of the present invention.
[0025] The present invention also includes a therapeutic
composition that, when administered to an animal, reduces
IgG-mediated tissue damage, said therapeutic composition comprising
an inhibitory compound that inhibits the activity of an
Fc.gamma.RIIIb protein, said inhibitory compound being identified
by the method comprising: (a) providing a three dimensional
structure of an Fc.gamma.RIIIb protein; (b) using said three
dimensional structure to design a chemical compound selected from
the group consisting of a compound that inhibits binding of
Fc.gamma.RIIIb protein to IgG, a compound that substantially mimics
the three dimensional structure of Fc.gamma.RIIIb protein and a
compound that inhibits binding of Fc.gamma.RIIIb protein with a
molecule that stimulates cellular signal transduction through an
Fc.gamma.RIIIb protein; (c) chemically synthesizing said chemical
compound; and (d) evaluating the ability of said synthesized
chemical compound to reduce IgG-mediated tissue damage.
[0026] One embodiment of the present invention is a therapeutic
composition that is capable of reducing IgE-mediated responses.
Such therapeutic compositions are capable of reducing IgE-mediated
responses resulting from IgE-mediated hypersensitivity,
IgE-mediated release of inflammatory modulators or other biological
mechanisms involved in IgE-mediated recruitment of inflammatory
cells that involves Fc.epsilon.R protein. Such a therapeutic
composition of the present invention can: (1) inhibit (i.e.,
prevent, block) binding of Fc.epsilon.R protein on a cell having an
Fc.epsilon.R protein (e.g., mast cells) to an IgE immune complex by
interfering with the IgE binding site of an Fc.epsilon.R protein;
(2) inhibit precipitation of IgE or IgE immune complexes (i.e.,
prevent Fc:Fc interactions between two IgE); (3) inhibit
immunoglobulin-mediated cellular signal transduction by interfering
with the binding of an IgE to a cell surface receptor; and (4)
inhibit Fc.epsilon.R-mediated cellular signal transduction by
interfering with the binding of a cell signal inducing molecule
(i.e., a molecule that induces cellular signal transduction through
an Fc.epsilon.R protein) to an Fc.epsilon.R protein. Such
therapeutic compositions include one or more inhibitory compounds
that inhibit binding of IgE to Fc.epsilon.R protein, IgE to IgE,
IgE to a cell surface receptor, or a cell signal inducing molecule
to Fc.epsilon.R protein. Also included in the present invention are
methods to reduce IgE-mediated responses, such as IgE-mediated
inflammation.
[0027] Another embodiment of the present invention is a therapeutic
composition that is capable of stimulating a IgE humoral immune
response in an animal. Yet another embodiment of the present
invention is a therapeutic composition that improves the
therapeutic affects of an antibody that is administered to an
animal to treat, by opsinization or Fc.epsilon.R-dependent effector
functions (e.g. phagocytosis or release of cellular mediators), a
particular disease. Such a therapeutic composition includes one or
more stimulatory compounds that have increased binding to IgE,
enhance binding of IgE to Fc.epsilon.RI, enhance dimer formation of
Fc.epsilon.RI and/or otherwise enhance signal transduction through
the Fc.epsilon.RI. Also included in the present invention is a
method to stimulate a humoral immune response. The method includes
the step of administering to an animal a therapeutic composition of
the present invention.
BRIEF DESCRIPTION OF THE FIGURES
[0028] FIG. 1 is a scanned image of SDS-PAGE analysis of
PsFc.gamma.RIIa protein during the purification process.
[0029] FIG. 2 is a scanned image of two-dimensional NEPHGE analysis
of purified PsFc.gamma.RIIa protein.
[0030] FIG. 3 illustrates Langmuir plots of purified
PsFc.gamma.RIIa protein binding to different isotypes of human
immunoglobulin G.
[0031] FIG. 4 illustrates a graphical representation of the dimer
of PFc.gamma.RIIa.
[0032] FIG. 5 illustrates the positions of the beta sheets in
Fc.gamma.RIIa Domains 1 and 2 and compares amino acid sequences of
isomorphs of Fc.gamma.RII.
[0033] FIG. 6 illustrates the stereo view of the Fc.gamma.RIIa
structure shown in FIG. 4.
[0034] FIG. 7 illustrates the location of amino acids involved in
binding of Fc.gamma.RIIa to IgG.
[0035] FIG. 8 illustrates an expanded view of an IgG binding region
showing position and side chains of the involved amino acids.
[0036] FIG. 9 illustrates an expanded view of an IgG binding region
showing amino acids which when mutated to alanine improves IgG
binding to Fc.gamma.RIIa.
[0037] FIG. 10 illustrates an expanded view of the region of one
Fc.gamma.RIIa monomer that contributes to the dimer interface.
[0038] FIG. 11 illustrates a comparison of the amino acid sequence
of Fc.gamma.RIIa protein with the amino acid sequences of
Fc.gamma.RI, Fc.gamma.RIIIb and Fc.epsilon.RI protein.
[0039] FIG. 12 illustrates a comparison of structural features
shared by Fc.gamma.RIIa, Fc.gamma.RI, Fc.gamma.RIIIb and
Fc.epsilon.RI proteins.
[0040] FIG. 13 illustrates a sequence alignment of the amino acid
sequences of Fc.gamma.RIIa and Fc.epsilon.RI.
[0041] FIG. 14 is a scanned image illustrating a worm
representation of the structure of an Fc.epsilon.RI monomer.
[0042] FIG. 15 is a scanned image illustrating a worm
representation of the structure of an Fc.epsilon.RI dimer.
[0043] FIG. 16 is a scanned image illustrating a molecular surface
representation of an Fc.epsilon.RI dimer model.
[0044] FIG. 17 is a schematic representation of target sites in the
FcR structure for drug design.
[0045] FIG. 18 illustrates a sequence alignment of the amino acid
sequences of Fc.gamma.RIIa and Fc.gamma.RIIIb.
DETAILED DESCRIPTION OF THE INVENTION
[0046] The present invention relates to the discovery of the
three-dimensional structure of Fc receptor (FcR) proteins, models
of such three-dimensional structures, a method of structure based
drug design using such structures, the compounds identified by such
methods and the use of such compounds in therapeutic compositions.
More particularly, the present invention relates to novel crystals
of Fc gamma receptor IIa (Fc.gamma.RIIa), novel crystals of Fc
epsilon receptor I (Fc.epsilon.RI), methods of production of such
crystals, three dimensional coordinates of Fc.gamma.RIIa protein, a
three dimensional structure of Fc.gamma.RIIa protein, FcR
structures and models derived from the Fc.gamma.RIIa structure,
including Fc.epsilon.RI and Fc.gamma.RIIIb, and uses of such
structure and models to derive other FcR structures and in drug
design strategies. It is to be noted that the term "a" or "an"
entity refers to one or more of that entity; for example, a
compound refers to one or more compounds or at least one compound.
As such, the terms "a" (or "an"), "one or more" and "at least one"
can be used interchangeably herein. It is also to be noted that the
terms "comprising", "including", and "having" can be used
interchangeably. Furthermore, a compound "selected from the group
consisting of" refers to one or more of the compounds in the list
that follows, including mixtures (i.e., combinations) of two or
more of the compounds. According to the present invention, an
isolated, or pure, protein, is a protein that has been removed from
its natural milieu. As such, "isolated" and "biologically pure" do
not necessarily reflect the extent to which the protein has been
purified. An isolated protein of the present invention can be
obtained from its natural source, can be produced using recombinant
DNA technology or can be produced by chemical synthesis. It is also
to be noted that the terms "tertiary" and "three dimensional" can
be used interchangeably. It is also to be noted that reference to
an "FcR protein" can also be recited simply as "FcR" and such terms
can be used to refer to a the complete FcR protein, a portion of
the FcR protein, such as a polypeptide, and/or a monomer or a dimer
of the FcR protein. When reference is specifically made to a
monomer or dimer, for example, such term is typically used in
conjunction with the FcR protein name.
[0047] The production of the crystal structure of Fc.gamma.RIIa has
been described in detail in U.S. Provisional Application Serial No.
60/073,972, filed Feb. 6, 1998. The entire disclosure of U.S.
Provisional Application Serial No. 60/073,972 is incorporated
herein by reference in its entirety.
[0048] One embodiment of the present invention includes a model of
an Fc receptor, in which the model represents a three dimensional
structure of an Fc receptor (FcR) protein. Another embodiment of
the present invention includes the three dimensional structure of
an FcR protein. A three dimensional structure of an FcR protein
encompassed by the present invention substantially conforms with
the atomic coordinates represented in any one of Tables 1-5.
According to the present invention, the use of the term
"substantially conforms" refers to at least a portion of a three
dimensional structure of an FcR protein which is sufficiently
spatially similar to at least a portion of a specified three
dimensional configuration of a particular set of atomic coordinates
(e.g., those represented by Table 1) to allow the three dimensional
structure of the FcR protein to be modeled or calculated (i.e., by
molecular replacement) using the particular set of atomic
coordinates as a basis for determining the atomic coordinates
defining the three dimensional configuration of the FcR protein.
According to the present invention, a three dimensional structure
of a dimer of a first FcR can substantially conform to the atomic
coordinates which represent a three dimensional structure of a
monomer of a second FcR, and vice versa. In the first instance, at
least a portion of the structure of the first FcR protein (i.e., a
monomer of the first FcR protein dimer) substantially conforms to
the atomic coordinates which represent the three dimensional
configuration of the second FcR monomer. In the second reversed
case, a first monomeric FcR protein substantially conforms to at
least a portion of the second FcR protein (i.e., a monomer of the
second FcR protein dimer) Similarly, a three dimensional structure
of a given portion or chain of a first FcR can substantially
conform to at least a portion of the atomic coordinates which
represent a three dimensional configuration of a second FcR.
[0049] More particularly, a structure that substantially conforms
to a given set of atomic coordinates is a structure wherein at
least about 50% of such structure has an average root-mean-square
deviation (RMSD) of less than about 1.5 .ANG. for the backbone
atoms in secondary structure elements in each domain, and more
preferably, less than about 1.3 .ANG. for the backbone atoms in
secondary structure elements in each domain, and, in increasing
preference, less than about 1.0 .ANG., less than about 0.7 .ANG.,
less than about 0.5 .ANG., and most preferably, less than about 0.3
.ANG. for the backbone atoms in secondary structure elements in
each domain. In a more preferred embodiment, a structure that
substantially conforms to a given set of atomic coordinates is a
structure wherein at least about 75% of such structure has the
recited average root-mean-square deviation (RMSD) value, and more
preferably, at least about 90% of such structure has the recited
average root-mean-square deviation (RMSD) value, and most
preferably, about 100% of such structure has the recited average
root-mean-square deviation (RMSD) value. In an even more preferred
embodiment, the above definition of "substantially conforms" can be
extended to include atoms of amino acid side chains. As used
herein, the phrase "common amino acid side chains" refers to amino
acid side chains that are common to both the structure which
substantially conforms to a given set of atomic coordinates and the
structure that is actually represented by such atomic coordinates.
Preferably, a three dimensional structure that substantially
conforms to a given set of atomic coordinates is a structure
wherein at least about 50% of the common amino acid side chains
have an average root-mean-square deviation (RMSD) of less than
about 1.5 .ANG., and more preferably, less than about 1.3 .ANG.,
and, in increasing preference, less than about 1.0 .ANG., less than
about 0.7 .ANG., less than about 0.5 .ANG., and most preferably,
less than about 0.3 .ANG.. In a more preferred embodiment, a
structure that substantially conforms to a given set of atomic
coordinates is a structure wherein at least about 75% of the common
amino acid side chains have the recited average root-mean-square
deviation (RMSD) value, and more preferably, at least about 90% of
the common amino acid side chains have the recited average
root-mean-square deviation (RMSD) value, and most preferably, about
100% of the common amino acid side chains have the recited average
root-mean-square deviation (RMSD) value.
[0050] A three dimensional structure of an FcR protein which
substantially conforms to a specified set of atomic coordinates can
be modeled by a suitable modeling computer program such as MODELER
(A. Sali and T. L. Blundell, J. Mol. Biol., vol. 234:779-815, 1993
as implemented in the Insight II Homology software package (Insight
II (97.0), MSI, San Diego)), using information, for example,
derived from the following data: (1) the amino acid sequence of the
FcR protein; (2) the amino acid sequence of the related portion(s)
of the protein represented by the specified set of atomic
coordinates having a three dimensional configuration; and, (3) the
atomic coordinates of the specified three dimensional
configuration. A three dimensional structure of an FcR protein
which substantially conforms to a specified set of atomic
coordinates can also be calculated by a method such as molecular
replacement, which is described in detail below.
[0051] A suitable three dimensional structure of an FcR protein for
use in modeling or calculating the three dimensional structure of
another FcR protein comprises the set of atomic coordinates
represented in Table 1. The set of three dimensional coordinates
set forth in Table 1 is represented in standard Protein Data Bank
format. According to the present invention, an FcR protein selected
from the group of Fc.gamma.RI, Fc.gamma.RIIa, Fc.gamma.RIIb,
Fc.gamma.RIIc, Fc.gamma.RIIIb, Fc.epsilon.RI and Fc.alpha.RI have a
three dimensional structure which substantially conforms to the set
of atomic coordinates represented by Table 1. As used herein, a
three dimensional structure can also be a most probable, or
significant, fit with a set of atomic coordinates. According to the
present invention, a most probable or significant fit refers to the
fit that a particular FcR protein has with a set of atomic
coordinates derived from that particular FcR protein. Such atomic
coordinates can be derived, for example, from the crystal structure
of the protein such as the coordinates determined for the
Fc.gamma.RIIa structure provided herein, or from a model of the
structure of the protein as determined herein for Fc.epsilon.RI and
Fc.gamma.RIIIb. For example, the three dimensional structure of a
monomeric Fc.gamma.RIIa protein, including a naturally occurring or
recombinantly produced Fc.gamma.RIIa protein, substantially
conforms to and is a most probable fit, or significant fit, with
the atomic coordinates of Table 1. The three dimensional crystal
structure of Fc.gamma.RIIa that was determined by the present
inventors comprises the atomic coordinates of Table 1. Also as an
example, the three dimensional structure of an Fc.epsilon.RI
protein substantially conforms to the atomic coordinates of Table 1
and both substantially conforms to and is a most probable fit with
the atomic coordinates of Table 3, and the three dimensional
structure of the model of Fc.epsilon.RI monomer determined by the
present inventors comprises the atomic coordinates of Table 3. This
definition can be applied to the other FcR proteins in a similar
manner.
[0052] A preferred structure of an FcR protein according to the
present invention substantially conforms to the atomic coordinates,
and the B-values and/or the thermal parameters represented in Table
1. Such values as listed in Table 1 can be interpreted by one of
skill in the art. A more preferred three dimensional structure of
an FcR protein substantially conforms to the three dimensional
coordinates represented in Table 1. An even more preferred three
dimensional structure of an FcR protein is a most probable fit with
the three dimensional coordinates represented in Table 1. Methods
to determine a substantially conforming and probable fit are within
the expertise of skill in the art and are described herein in the
Examples section.
[0053] A preferred FcR protein that has a three dimensional
structure which substantially conforms to the atomic coordinates
represented by Table 1 includes an FcR protein having an amino acid
sequence that is at least about 25%, preferably at least about 30%,
more preferably at least about 40%, more preferably at least about
50%, more preferably at least about 60%, more preferably at least
about 70%, more preferably at least about 80% and more preferably
at least about 90%, identical to an amino acid sequence of an
Fc.gamma.RIIa protein, preferably an amino acid sequence including
SEQ ID NO:3, SEQ ID NO:10, SEQ ID NO:11 and/or SEQ ID NO:12, across
the full-length of the FcR sequence when using, for example, a
sequence alignment program such as the DNAsis.TM. program
(available from Hitachi Software, San Bruno, Calif.) or the
MacVector.TM. program (available from the Eastman Kodak Company,
New Haven, Conn.) or the GC.gamma..TM. program (available from
"GC.gamma.", University of Wisconsin, Madison, Wis.), such
alignment being performed for example, using the standard default
values accompanying such alignment programs.
[0054] One embodiment of the present invention includes a three
dimensional structure of Fc.gamma.RIIa protein. A suitable three
dimensional structure of Fc.gamma.RIIa protein substantially
conforms with the atomic coordinates represented in Table 1. A
suitable three dimensional structure of Fc.gamma.RIIa also
substantially conforms with the atomic coordinates represented by
Tables 2-5. A suitable three dimensional structure of Fc.gamma.RIIa
protein also comprises the set of atomic coordinates represented in
Table 1. The set of three dimensional coordinates of Fc.gamma.RIIa
protein is represented in standard Protein Data Bank format. A
preferred structure of Fc.gamma.RIIa protein substantially conforms
to the atomic coordinates, and the B-values and/or the thermal
parameters represented in Table 1 (monomeric Fc.gamma.RIIa) or
Table 2 (dimeric Fc.gamma.RIIa). Such values as listed in Table 1
can be interpreted by one of skill in the art. A more preferred
three dimensional structure of Fc.gamma.RIIa protein has a most
probable fit with the three dimensional coordinates represented in
Table 1.
[0055] One embodiment of the present invention includes a three
dimensional structure of Fc.epsilon.RI protein. A suitable three
dimensional structure of Fc.epsilon.RI protein substantially
conforms with the atomic coordinates represented in Table 1, Table
2, Table 3, Table 4 or Table 5. A more suitable three dimensional
structure of Fc.epsilon.RI protein substantially conforms with the
sets of atomic coordinates represented in Table 3 (monomeric
Fc.epsilon.RI) or Table 4 (dimeric Fc.epsilon.RI). A suitable three
dimensional structure of Fc.epsilon.RI protein also comprises the
set of atomic coordinates represented in Tables 3 or 4. The sets of
three dimensional coordinates of Fc.epsilon.RI protein are
represented in standard Protein Data Bank format. Such coordinates
as listed in Tables 1-5 can be interpreted by one of skill in the
art. A more preferred three dimensional structure of Fc.epsilon.RI
protein has a probable fit with the three dimensional coordinates
represented in Table 3 or Table 4.
[0056] One embodiment of the present invention includes a three
dimensional structure of Fc.gamma.RIIIb protein. A suitable three
dimensional structure of Fc.gamma.RIIIb protein substantially
conforms with the atomic coordinates represented in Table 1, Table
2, Table 3, Table 4 or Table 5. An even more suitable three
dimensional structure of Fc.gamma.RIIIb protein substantially
conforms with the set of atomic coordinates represented in Table 5.
A suitable three dimensional structure of Fc.gamma.RIIIb protein
also comprises the set of atomic coordinates represented in Table
5. The sets of three dimensional coordinates of Fc.gamma.RIIIb
protein are represented in standard Protein Data Bank format. A
more preferred three dimensional structure of Fc.gamma.RIIIb
protein has a most probable fit with the three dimensional
coordinates represented in Table 5.
[0057] A three dimensional structure of any FcR protein can be
modeled using methods generally known in the art based on
information obtained from analysis of an Fc.gamma.RIIa crystal, and
from other FcR structures which are derived from an Fc.gamma.RIIa
crystal. The Examples section below discloses the production of an
Fc.gamma.RIIa crystal, the production of an Fc.epsilon.RI crystal,
the three dimensional structure of an Fc.gamma.RIIa protein monomer
and dimer derived from the Fc.gamma.RIIa crystal, and the model of
the three dimensional structure of an Fc.epsilon.RI protein monomer
and dimer using methods generally known in the art based on the
information obtained from analysis of an Fc.gamma.RIIa crystal. It
is an embodiment of the present invention that the three
dimensional structure of a crystalline FcR, such as the crystalline
Fc.gamma.RIIa, can be used to derive the three dimensional
structure of any other FcR, such as the Fc.epsilon.RI disclosed
herein. Subsequently, the derived three dimensional structure of
such an FcR (e.g., Fc.epsilon.RI) derived from the crystalline
structure of Fc.gamma.RIIa can be used to derive the three
dimensional structure of other FcR, such as FcR.gamma.III.
Therefore, the novel discovery herein of the crystalline
Fc.gamma.RIIa and the three dimensional structure of Fc.gamma.RIIa
permits one of ordinary skill in the art to now derive the three
dimensional structure, and models thereof, of any FcR. The
derivation of the structure of any FcR can now be achieved even in
the absence of having crystal structure data for such other FcR,
and when the crystal structure of another FcR is available, the
modeling of the three dimensional structure of the new FcR can be
refined using the knowledge already gained from the Fc.gamma.RIIa
structure. It is an advantage of the present invention that, in the
absence of crystal structure data for other FcR proteins, the three
dimensional structures of other FcR proteins can be modeled, taking
into account differences in the amino acid sequence of the other
FcR. Indeed, the recent report of the crystallization of the
monomeric Fc.epsilon.RI and publication of a model of the receptor
(Garman et al., Dec. 23, 1998, Cell 95:951-961) subsequent to the
priority filing dates of the present application has confirmed that
the monomeric Fc.epsilon.RI protein determined by the present
inventors comprising the atomic coordinates represented in Table 3
has the overall gross structural features of the three dimensional
structure of the crystalline Fc.epsilon.RI reported in Garman et
al. Although the atomic coordinates of the crystalline
Fc.epsilon.RI structure of Garman et al. are not currently publicly
available, a review of the structural representations and
discussion in Garman et al. indicates that the three dimensional
structure of the crystalline Fc.epsilon.RI is expected to
substantially conform to the atomic coordinates represented by
Table 3. Moreover, the novel discoveries of the present invention
allow for structure based drug design of compounds which affect the
activity of virtually any FcR, and particularly, of Fc.gamma.R and
Fc.epsilon.RI.
[0058] Crystals are derivatized with heavy atom compounds such as
complexes or salts of Pt, Hg, Au and Pb and X-ray diffraction data
are measured for native and derivatized crystals. Differences in
diffraction intensities for native crystals and derivatized
crystals can be used to determine phases for these data by the
methods of MIR (muliple Isomorphous Replacement) or SIRAS (single
isomorphous replacement with anomalous scattering). The Fourier
transform of these data yield a low resolution electron density map
for the protein. This electron density can be modified by image
enhancement techniques. A molecular model for the protein is then
placed in the electron density. This initial (partial) structure
can be refined using a computer program (such as XPLOR) by
modifying the parameters which describe the structure to minimize
the difference between the measured and calculated diffraction
patterns, while simultaneously restraining the model to conform to
known geometric and chemical properties of proteins. New phases and
a thus a new electron density map can be calculated for protein.
Using this map as a guide the molecular model of the structure may
be improved manually. This procedure is repeated to give the
structure of the protein, represented herein for Fc.gamma.RIIa as a
set of atomic coordinates in Table 1.
[0059] One embodiment of the present invention includes a three
dimensional structure of Fc.gamma.RIIa protein, in which the atomic
coordinates of the Fc.gamma.RIIa protein are generated by the
method comprising: (a) providing Fc.gamma.RIIa protein in
crystalline form; (b) generating an electron-density map of the
crystalline Fc.gamma.RIIa protein; and (c) analyzing the
electron-density map to produce the atomic coordinates.
[0060] According to the present invention, a three dimensional
structure of Fc.gamma.RIIa protein of the present invention can be
used to derive a model of the three dimensional structure of
another FcR protein (i.e., a structure to be modeled). As used
herein, a "structure" of a protein refers to the components and the
manner of arrangement of the components to constitute the protein.
As used herein, the term "model" refers to a representation in a
tangible medium of the three dimensional structure of a protein,
polypeptide or peptide. For example, a model can be a
representation of the three dimensional structure in an electronic
file, on a computer screen, on a piece of paper (i.e., on a two
dimensional medium), and/or as a ball-and-stick figure. Physical
three-dimensional models are tangible and include, but are not
limited to, stick models and space-filling models. The phrase
"imaging the model on a computer screen" refers to the ability to
express (or represent) and manipulate the model on a computer
screen using appropriate computer hardware and software technology
known to those skilled in the art. Such technology is available
from a variety of sources including, for example, Evans and
Sutherland, Salt Lake City, Utah, and Biosym Technologies, San
Diego, Calif. The phrase "providing a picture of the model" refers
to the ability to generate a "hard copy" of the model. Hard copies
include both motion and still pictures. Computer screen images and
pictures of the model can be visualized in a number of formats
including space-filling representations, .alpha. carbon traces,
ribbon diagrams (see, for example, FIG. 14 which is a two
dimensional ribbon diagram model of a three-dimensional structure
of human Fc.epsilon.RI protein) and electron density maps.
[0061] Suitable target FcR structures to model using a method of
the present invention include any FcR protein, polypeptide or
peptide, including monomers, dimers and multimers of an FcR
protein, that is substantially structurally related to an
Fc.gamma.RIIa protein. A preferred target FcR structure that is
substantially structurally related to an Fc.gamma.RIIa protein
includes a target FcR structure having an amino acid sequence that
is at least about 25%, preferably at least about 30%, more
preferably at least about 36%, more preferably at least about 40%,
more preferably at least about 50%, more preferably at least about
60%, more preferably at least about 70%, more preferably at least
about 80% and more preferably at least about 90%, identical to an
amino acid sequence of an Fc.gamma.RIIa protein, preferably an
amino acid sequence including SEQ ID NO:3, SEQ ID NO:10, SEQ ID
NO:11, SEQ ID NO:12, SEQ ID NO:14 and/or SEQ ID NO:15, across the
full-length of the target FcR structure sequence when using, for
example, a sequence alignment program such as the DNAsis.TM.
program (available from Hitachi Software, San Bruno, Calif.) or the
MacVector.TM. program (available from the Eastman Kodak Company,
New Haven, Conn.) or the GC.gamma..TM. program (available from
"GC.gamma.", University of Wisconsin, Madison, Wis.), such
alignment being performed for example, using the standard default
values accompanying such alignment programs. More preferred target
FcR structures to model include proteins comprising amino acid
sequences that are at least about 50%, preferably at least about
60%, more preferably at least about 70%, more preferably at least
about 80%, more preferably at least about 90%, and more preferably
at least about 95%, identical to amino acid sequence SEQ ID NO:3,
SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9,
SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, or SEQ ID NO:13 when
comparing preferred regions of the sequence, such as the amino acid
sequence for Domain 1 or Domain 2 of any one of the amino acid
sequences, when using a DNA alignment program disclosed herein to
align the amino acid sequences. A more preferred target FcR
structure to model includes a structure comprising Fc.gamma.RI,
Fc.gamma.RIIa, Fc.gamma.RIIb, Fc.gamma.RIIc, Fc.gamma.RIIIb,
Fc.epsilon.RI or Fc.alpha.RI protein, more preferably a structure
comprising the amino acid sequence SEQ ID NO:3, SEQ ID NO:5, SEQ ID
NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID
NO:11, SEQ ID NO:12, or SEQ ID NO:13 and more preferably a
structure consisting of the amino acid sequence SEQ ID NO:3, SEQ ID
NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID
NO:10, SEQ ID NO:11, SEQ ID NO:12, or SEQ ID NO:13.
[0062] Preferred target FcR structures to model also include, but
are not limited to, derivations of Fc receptor proteins, such as an
Fc receptor having one or more amino acid residues substituted,
deleted or added (referred to herein as Fc receptor mutants), or
proteins encoded by natural allelic variants of a nucleic acid
molecule encoding an Fc receptor. A preferred Fc receptor protein
to model includes Fc.gamma.RIIa.gamma.Tm (i.e., an Fc.gamma.RIIa
protein from which the transmembrane domain has been deleted), and
mutants or natural allelic variants of a nucleic acid molecule
encoding Fc.gamma.RI, Fc.gamma.RIIa, Fc.gamma.RIIb, Fc.gamma.RIIc,
Fc.gamma.RIIIb, Fc.epsilon.RI, Fc.alpha.RI protein. More preferred
Fc receptor proteins to model include Fc receptor proteins having
an amino acid sequence including SEQ ID NO:5, SEQ ID NO:6, SEQ ID
NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID
NO:12, or SEQ ID NO:13 or mutants or natural allelic variants of
SEQ ID NO:3, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8,
SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, or SEQ ID
NO:13. According to the present invention, an amino acid sequence
for Fc.gamma.RIIb is represented herein as SEQ ID NO:5, an amino
acid sequence for Fc.gamma.RIIc is represented herein as SEQ ID
NO:6, an amino acid sequence for Fc.gamma.RI is represented herein
as SEQ ID NO:7, an amino acid sequence for Fc.gamma.RIII is
represented herein as SEQ ID NO:8, an amino acid sequence for
Fc.epsilon.RI is represented herein as SEQ ID NO:9 and as set forth
in FIG. 13, and an amino acid sequence for Fc.alpha.RI is
represented herein as SEQ ID NO:13. It is noted that the nucleotide
and amino acid sequences for all of the above-known FcR are known
and publicly available. Preferred allelic variants to model
include, but are not limited to, Fc.gamma.RIIa allelic variants
having a glutamine at residue 27 of SEQ ID NO:3 and an arginine at
residue 131 of SEQ ID NO:3, represented herein as SEQ ID NO:10; a
tryptophan at residue 27 of SEQ ID NO:3 and a histidine at residue
131 of SEQ ID NO:3, represented herein as SEQ ID NO:11; or a
tryptophan at residue 27 of SEQ ID NO:3 and an arginine at residue
131 of SEQ ID NO:3, represented herein as SEQ ID NO:12.
[0063] As used herein, a "natural allelic variant" refers to
alternative forms of a gene that occupies corresponding loci on
homologous chromosomes. Allelic variants typically encode proteins
having similar activity to that of the protein encoded by the gene
to which they are being compared. Allelic variants can also
comprise alterations in the 5' or 3' untranslated regions of the
gene (e.g., in regulatory control regions). Allelic variants are
well known to those skilled in the art and would be expected to be
found within a given group of genes encoding an Fc receptor in a
given species of animal.
[0064] As used herein, "mutants of a nucleic acid molecule encoding
an Fc receptor" refer to nucleic acid molecules modified by
nucleotide insertions, deletions and/or substitutions. Preferably,
a mutant of an Fc receptor nucleic acid molecule comprises
modifications such that the protein encoded by the mutant of an Fc
receptor nucleic acid molecule (i.e., an Fc receptor protein
mutant) has one or more epitopes that can be targeted by a humoral
or cellular immune response against a non-mutated Fc receptor
protein. More preferably, the nucleic acid molecule encoding a
mutant Fc receptor protein can form a stable hybrid with a nucleic
acid sequence encoding a non-mutated Fc receptor nucleic acid
molecule under stringent hybridization conditions. Even more
preferably, the nucleic acid molecule encoding a mutant Fc receptor
protein can form a stable hybrid, under stringent hybridization
conditions, with a nucleic acid sequence encoding an amino acid
sequence including SEQ ID NO:3, SEQ ID NO:5, SEQ ID NO:6, SEQ ID
NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID
NO:12, or SEQ ID NO:13.
[0065] As used herein, stringent hybridization conditions refer to
standard hybridization conditions under which nucleic acid
molecules are used to identify similar nucleic acid molecules. Such
standard conditions are disclosed, for example, in Sambrook et al.,
Molecular Cloning: A Laboratory Manual, Cold Spring Harbor Labs
Press, 1989. Sambrook et al., ibid., is incorporated by reference
herein in its entirety (see specifically, pages 9.31-9.62, 11.7 and
11.45-11.61). In addition, formulae to calculate the appropriate
hybridization and wash conditions to achieve hybridization
permitting varying degrees of mismatch of nucleotides are
disclosed, for example, in Meinkoth et al., 1984, Anal. Biochem.
138, 267-284; Meinkoth et al., ibid., is incorporated by reference
herein in its entirety.
[0066] More particularly, stringent hybridization conditions, as
referred to herein, refer to conditions which permit isolation of
nucleic acid molecules having at least about 70% nucleic acid
sequence identity with the nucleic acid molecule being used to
probe in the hybridization reaction, more particularly at least
about 75%, and most particularly at least about 80%. Such
conditions will vary, depending on whether DNA:RNA or DNA:DNA
hybrids are being formed. Calculated melting temperatures for
DNA:DNA hybrids are 10.degree. C. less than for DNA:RNA hybrids. In
particular embodiments, stringent hybridization conditions for
DNA:DNA hybrids include hybridization at an ionic strength of
0.1.times.SSC (0.157 M Na.sup.+) at a temperature of between about
20.degree. C. and about 35.degree. C., more preferably, between
about 28.degree. C. and about 40.degree. C., and even more
preferably, between about 35.degree. C. and about 45.degree. C. In
particular embodiments, stringent hybridization conditions for
DNA:RNA hybrids include hybridization at an ionic strength of
0.1.times.SSC (0.157 M Na.sup.+) at a temperature of between about
30.degree. C. and about 45.degree. C., more preferably, between
about 38.degree. C. and about 50.degree. C., and even more
preferably, between about 45.degree. C and about 55.degree. C.
These values are based on calculations of a melting temperature for
molecules larger than about 100 nucleotides, 0% formamide and a G+C
content of about 50%. Alternatively, T.sub.m can be calculated
empirically as set forth in Sambrook et al., supra, pages 11.55 to
11.57.
[0067] A model of the present invention can be derived using
conserved structural features between the known three dimensional
structure of one FcR protein, such as Fc.gamma.RIIa, and another
target FcR structure. Such structural features include, but are not
limited to, amino acid sequence, conserved di-sulphide bonds, and
.beta.-strands or .beta.-sheets that are highly conserved in
immunoglobulin superfamily members. For example, FIGS. 5, 11 and 12
illustrate the relationship of .beta.-strands with the linear amino
acid sequence of various Fc receptor proteins. Preferably, a model
of the present invention is derived by starting with the backbone
of the three dimensional structure of Fc.gamma.RIIa protein.
Individual residues are then replaced according to the amino acid
sequence of the target FcR structure at residues that differ from
the amino acid sequence of an Fc.gamma.RIIa protein. Care is taken
that replacement of residues does not disturb the tertiary
structure of the backbone. While procedures to model target FcR
structures are generally known in the art, the present invention
provides the first three dimensional structure of Fc.gamma.RIIa
protein and the first three dimensional structures of protein
substantially related to a member of the family of Fc.gamma.R
receptors, an Fc.epsilon.RI and an Fc.gamma.RIIIb. Thus, the
present invention provides essential information to produce
accurate, and therefore, useful models of a member of the family of
Fc.gamma.R receptors, of the Fc.epsilon.RI receptor and of the
Fc.alpha.RI receptor. As discussed above, once the three
dimensional structure of a second FcR has been derived from a
determined three dimensional structure of a first FcR such as
Fc.gamma.RIIa disclosed herein, the second FcR three dimensional
structure can be used to derive (i.e., model or calculate) the
three dimensional structure of another FcR.
[0068] According to the present invention, a structure can be
modeled using techniques generally described by, for example, Sali,
Current Opinions in Biotechnology, vol. 6, pp. 437-451, 1995, and
algorithms can be implemented in program packages such as Homology
95.0 (in the program Insight II, available from Biosym/MSI, San
Diego, Calif.). Use of Homology 95.0 requires an alignment of an
amino acid sequence of a known structure having a known three
dimensional structure with an amino acid sequence of a target
structure to be modeled. The alignment can be a pairwise alignment
or a multiple sequence alignment including other related sequences
(for example, using the method generally described by Rost, Meth.
Enzymol., vol. 266, pp. 525-539, 1996) to improve accuracy.
Structurally conserved regions can be identified by comparing
related structural features, or by examining the degree of sequence
homology between the known structure and the target structure.
Certain coordinates for the target structure are assigned using
known structures from the known structure. Coordinates for other
regions of the target structure can be generated from fragments
obtained from known structures such as those found in the Protein
Data Bank maintained by Brookhaven National Laboratory, Upton, N.Y.
Conformation of side chains of the target structure can be assigned
with reference to what is sterically allowable and using a library
of rotamers and their frequency of occurrence (as generally
described in Ponder and Richards, J. Mol. Biol., vol. 193, pp.
775-791, 1987). The resulting model of the target structure, can be
refined by molecular mechanics (such as embodied in the program
Discover, available from Biosym/MSI) to ensure that the model is
chemically and conformationally reasonable.
[0069] Accordingly, one embodiment of the present invention is a
method to derive a model of the three dimensional structure of a
target FcR structure, the method comprising the steps of: (a)
providing an amino acid sequence of an Fc.gamma.RIIa protein and an
amino acid sequence of a target FcR structure; (b) identifying
structurally conserved regions shared between the Fc.gamma.RIIa
amino acid sequence and the target FcR structure amino acid
sequence; (c) determining atomic coordinates for the target FcR
structure by assigning said structurally conserved regions of the
target FcR structure to a three dimensional structure using a three
dimensional structure of an Fc.gamma.RIIa protein based on atomic
coordinates that substantially conform to the atomic coordinates
represented in Table 1, to derive a model of the three dimensional
structure of the target structure amino acid sequence. A model
according to the present invention has been previously described
herein. Preferably the model comprises a computer model. The method
can further comprise the step of electronically simulating the
structural assignments to derive a computer model of the three
dimensional structure of the target structure amino acid sequence.
Suitable target structures to model include proteins, polypeptides
and peptides of Fc receptors disclosed herein, including monomers
and dimers of such receptors. Preferred amino acid sequences to
model are disclosed herein.
[0070] Another embodiment of the present invention is a method to
derive a computer model of the three dimensional structure of a
target FcR structure for which a crystal has been produced
(referred to herein as a "crystallized target structure"). A
suitable method to produce such a model includes the method
comprising molecular replacement. Methods of molecular replacement
are generally known by those of skill in the art (generally
described in Brunger, Meth. Enzym., vol. 276, pp. 558-580, 1997;
Navaza and Saludjian, Meth. Enzym., vol. 276, pp. 581-594, 1997;
Tong and Rossmann, Meth. Enzym., vol. 276, pp. 594-611, 1997; and
Bentley, Meth. Enzym., vol. 276, pp. 611-619, 1997, each of which
are incorporated by this reference herein in their entirety) and
are performed in a software program including, for example, XPLOR.
According to the present invention, X-ray diffraction data is
collected from the crystal of a crystallized target structure. The
X-ray diffraction data is transformed to calculate a Patterson
function. The Patterson function of the crystallized target
structure is compared with a Patterson function calculated from a
known structure (referred to herein as a search structure). The
Patterson function of the crystallized target structure is rotated
on the search structure Patterson function to determine the correct
orientation of the crystallized target structure in the crystal.
The translation function is then calculated to determine the
location of the target structure with respect to the crystal axes.
Once the crystallized target structure has been correctly
positioned in the unit cell, initial phases for the experimental
data can be calculated. These phases are necessary for calculation
of an electron density map from which structural differences can be
observed and for refinement of the structure. Preferably, the
structural features (e.g., amino acid sequence, conserved
di-sulphide bonds, and .beta.-strands or .beta.-sheets) of the
search molecule are related to the crystallized target structure.
Preferably, a crystallized target FcR structure useful in a method
of molecular replacement according to the present invention has an
amino acid sequence that is at least about 25%, more preferably at
least about 30%, more preferably at least about 40%, more
preferably at least about 50%, more preferably at least about 60%,
more preferably at least about 70%, more preferably at least about
80% and more preferably at least about 90% identical to the amino
acid sequence of the search structure (e.g., Fc.gamma.RIIa), when
the two amino acid sequences are compared using a DNA alignment
program disclosed herein. A preferred search structure of the
present invention includes an Fc.gamma.RIIa protein comprising an
amino acid sequence including SEQ ID NO:3, SEQ ID NO:10, SEQ ID
NO:11, SEQ ID NO:12, SEQ ID NO:14 or SEQ ID NO:15. A more preferred
search structure of the present invention includes an Fc.gamma.RIIa
protein having a three dimensional structure that substantially
conforms with the atomic coordinates listed in Table 1. Preferably,
a Patterson function of a crystalline Fc.gamma.RIIa protein is
derived from X-ray diffraction of an Fc.gamma.RIIa crystal of the
present invention. A preferred target FcR structure for use in a
molecular replacement strategy of the present invention includes
Fc.gamma.RI, Fc.gamma.RIIb, Fc.gamma.RIIc, Fc.gamma.RIII,
Fc.epsilon.RI and/or Fc.alpha.RI, and most preferably,
Fc.epsilon.RI and Fc.gamma.RIIIb.
[0071] A preferred embodiment of the present invention includes a
method to derive a three dimensional structure of a crystallized
target FcR structure (i.e. a crystallized FcR protein), said method
comprising the steps of: (a) comparing the Patterson function of a
crystallized target FcR structure with the Patterson function of
crystalline Fc.gamma.RIIa protein to produce an electron-density
map of said crystallized target FcR structure; and (b) analyzing
the electron-density map to produce the three dimensional structure
of the crystallized target FcR structure.
[0072] Another embodiment of the present invention is a method to
determine a three dimensional structure of a target structure, in
which the three dimensional structure of the target FcR structure
is not known. Such a method is useful for identifying structures
that are related to the three dimensional structure of an
Fc.gamma.RIIa protein based only on the three dimensional structure
of the target structure. Thus, the present method enables
identification of structures that do not have high amino acid
identity with an Fc.gamma.RIIa protein but which do share three
dimensional structure similarities. A preferred method to determine
a three dimensional structure of a target FcR structure comprises:
(a) providing an amino acid sequence of a target structure, wherein
the three dimensional structure of the target structure is not
known; (b) analyzing the pattern of folding of the amino acid
sequence in a three dimensional conformation by fold recognition;
and (c) comparing the pattern of folding of the target structure
amino acid sequence with the three dimensional structure of
Fc.gamma.RIIa protein to determine the three dimensional structure
of the target structure, wherein the three dimensional structure of
the Fc.gamma.RIIa protein substantially conforms to the atomic
coordinates represented in Table 1. Preferred methods of fold
recognition include the methods generally described in Jones, Curr.
Opinion Struc. Biol., vol. 7, pp. 377-387, 1997. Such folding can
be analyzed based on hydrophobic and/or hydrophilic properties of a
target structure.
[0073] One embodiment of the present invention includes a three
dimensional computer image of the three dimensional structure of an
FcR protein. Suitable structures of which to produce three
dimensional computer images are disclosed herein. Preferably, a
computer image is created to a structure substantially conforms
with the three dimensional coordinates listed in Table 1. A
computer image of the present invention can be produced using any
suitable software program, including, but not limited to, MOLSCRIPT
2.0 (Avatar Software AB, Heleneborgsgatan 21C, SE-11731 Stockholm,
Sweden), the graphical display program 0 (Jones et. al., Acta
Crystallography, vol. A47, p. 110, 1991) or the graphical display
program GRASP. Suitable computer hardware useful for producing an
image of the present invention are known to those of skill in the
art. Preferred computer hardware includes a Silicon Graphics
Workstation.
[0074] Another embodiment of the present invention relates to a
computer-readable medium encoded with a set of three dimensional
coordinates selected from the group of the three dimensional
coordinates represented in Table 1, the three dimensional
coordinates represented in Table 2, the three dimensional
coordinates represented in Table 3, the three dimensional
coordinates represented in Table 4, and the three dimensional
coordinates represented in Table 5, wherein, using a graphical
display software program, the three dimensional coordinates create
an electronic file that can be visualized on a computer capable of
representing said electronic file as a three dimensional image.
Preferably, the three dimensional structure is of an FcR protein
selected from the group of Fc.gamma.RIIa, Fc.epsilon.RI, and
Fc.gamma.RIIIb.
[0075] Yet another embodiment of the present invention relates to a
computer-readable medium encoded with a set of three dimensional
coordinates of a three dimensional structure which substantially
conforms to the three dimensional coordinates represented in Table
1, wherein, using a graphical display software program, the set of
three dimensional coordinates create an electronic file that can be
visualized on a computer capable of representing said electronic
file as a three dimensional image. Preferably, the three
dimensional structure is of an FcR protein selected from the group
of Fc.gamma.RI, Fc.gamma.RIIa, Fc.gamma.RIIb, Fc.gamma.RIIc,
Fc.gamma.RIII, Fc.epsilon.RI and Fc.alpha.RI.
[0076] Another embodiment of the present invention relates to a two
dimensional image of an FcR including those illustrated in FIG. 4,
FIG. 6, FIG. 7, FIG. 8, FIG. 9, FIG. 10, FIG. 14, FIG. 15 or FIG.
16. Most of these figures were drawn with MOLSCRIPT 2.0 (Avatar
Software AB, Heleneborgsgatan 21C, SE-11731 Stockholm, Sweden).
[0077] One embodiment of the present invention includes an image of
FcR protein that is generated when a set of three dimensional
coordinates comprising the three dimensional coordinates
represented in Table 1 are analyzed on a computer using a graphical
display software program to create an electronic file of said image
and visualizing said electronic file on a computer capable of
representing electronic file as a three dimensional image. Suitable
graphical software display programs include MOLSCRIPT 2.0, 0 and
GRASP. A suitable computer to visualize such image includes a
Silicon Graphics Workstation. Suitable structures and models to
image are disclosed herein. Preferably, the three dimensional
structures and/or models are of an FcR protein selected from the
group of Fc.gamma.RI, Fc.gamma.RIIa, Fc.gamma.RIIb, Fc.gamma.RIIc,
Fc.gamma.RIII, Fc.epsilon.RI and Fc.alpha.RI.
[0078] The present invention also includes a three dimensional
model of the three dimensional structure of a target structure
including Fc.gamma.RI protein, Fc.gamma.RIIa, Fc.gamma.RIIb
protein, Fc.gamma.RIIc protein, Fc.gamma.RIIIb protein,
Fc.epsilon.RI protein, and Fc.alpha.RI protein, such a three
dimensional model being produced by the method comprising: (a)
providing an amino acid sequences of an Fc.gamma.RIIa protein and
an amino acid sequence of a target FcR structure; (b) identifying
structurally conserved regions shared between the Fc.gamma.RIIa
amino acid sequence and the target FcR structure amino acid
sequence; (c) determining atomic coordinates for the FcR protein by
assigning the structurally conserved regions of the target FcR
structure to a three dimensional structure using a three
dimensional structure of an Fc.gamma.RIIa protein based on atomic
coordinates that substantially conform to the atomic coordinates
represented in Table 1 to derive a model of the three dimensional
structure of the target FcR structure amino acid sequence.
Preferably, the model comprises a computer model. Preferably, the
method further comprises the step of electronically simulating the
structural assignments to derive a computer model of the three
dimensional structure of the target FcR structure amino acid
sequence. Preferred amino acid sequences of Fc.gamma.RI protein,
Fc.gamma.RIIb protein, Fc.gamma.RIIc protein, Fc.gamma.RIIIb
protein and Fc.epsilon.RI protein are disclosed herein.
[0079] One embodiment of the present invention includes a method
for producing crystals of Fc.gamma.RIIa, comprising combining
Fc.gamma.RIIa protein with a mother liquor and inducing crystal
formation to produce the Fc.gamma.RIIa crystals. Another embodiment
of the present invention includes a method for producing crystals
of Fc.epsilon.RI, comprising combining Fc.epsilon.RI protein with a
mother liquor and inducing crystal formation to produce the
Fc.epsilon.RI crystals. Although the production of crystals of
Fc.gamma.RIIa and Fc.epsilon.RI are specifically described herein,
it is to be understood that such processes as are described herein
can be adapted by those of skill in the art to produce crystals of
other Fc receptors (FcR), particularly Fc.gamma.RI, Fc.gamma.RIIb,
Fc.gamma.RIIc, Fc.gamma.RIIIb and Fc.alpha.RI, the three
dimensional structures of which are also encompassed by the present
invention.
[0080] Preferably, crystals of Fc.gamma.RIIa are formed using a
solution containing a range of Fc.gamma.RIIa protein from about 1
mg/ml to about 20 mg/ml, more preferably from about 2 mg/ml to
about 15 mg/ml, and even more preferably from about 3 mg/ml to
about 6 mg/ml of Fc.gamma.RIIa protein in a mother liquor, with 3
mg/ml and 6 mg/ml of Fc.gamma.RIIa protein in a mother liquor being
more preferred. Preferably, crystals are formed using droplets
containing from about 1 .mu.g to about 30 .mu.g, more preferably
from about 5 .mu.g to about 25 .mu.g, and more preferably from
about 4.5 .mu.g to about 9 .mu.g of Fc.gamma.RIIa protein per 3
.mu.l droplet.
[0081] A suitable mother liquor of the present invention comprises
an acetate salt buffer. A preferred acetate salt buffer of the
present invention comprises ammonium acetate. The concentration of
ammonium acetate in the buffer prior to crystallization can range
from about 100 mM to about 500 mM ammonium acetate. Preferably, the
concentration of ammonium acetate in the buffer ranges from about
150 mM to about 300 mM ammonium acetate. More preferably, the
concentration of ammonium acetate in the buffer is 200 mM ammonium
acetate. A suitable acetate salt buffer preferably includes a
buffer having a pH of from about 5 to about 7, more preferably from
about 5.5 to about 6.5, and more preferably a pH of about 5.6.
Preferably, the pH of an acetate salt buffer or the present
invention is controlled using sodium citrate. A suitable acetate
salt buffer contains sodium citrate at a concentration of about
0.01 M sodium citrate, more preferably 0.05 M sodium citrate and
more preferably 0.1 M sodium citrate. A suitable acetate salt
buffer contains any polyethylene glycol (PEG), with PEG 4000 being
more preferred. Suitable PEG 4000 concentrations in an acetate salt
buffer of the present invention include a concentration of about
20%, preferably about 25%, and more preferably about 30% PEG
4000.
[0082] Another suitable mother liquor of the present invention
comprises a sulphate buffer. A preferred sulphate buffer of the
present invention comprises lithium sulfate. The concentration of
lithium sulfate in the buffer prior to crystallization can range
from about 100 mM to about 2.5 M lithium sulfate. Preferably, the
concentration of lithium sulfate in the buffer ranges from about
500 mM to about 2 M lithium sulfate. More preferably, the
concentration of lithium sulfate in the buffer is about 1.5 M
lithium sulfate. A suitable sulphate buffer preferably includes a
buffer having a pH of from about 5 to about 9, more preferably from
about 6 to about 8, and more preferably a pH of about 7.5.
Preferably, the pH of a sulphate buffer or the present invention is
controlled using HEPES. A suitable sulphate buffer contains HEPES
at a concentration of about 0.01 M HEPES, more preferably 0.05 M
HEPES and more preferably 0.1 M HEPES.
[0083] Supersaturated solutions of Fc.gamma.RIIa protein can be
induced to crystallize by several methods including, but not
limited to, vapor diffusion, liquid diffusion, batch
crystallization, constant temperature and temperature induction or
a combination thereof. Preferably, supersaturated solutions of
Fc.gamma.RIIa protein are induced to crystallize by vapor diffusion
(i.e., hanging drop method). In a vapor diffusion method, an
Fc.gamma.RIIa protein is combined with a mother liquor of the
present invention that will cause the Fc.gamma.RIIa protein
solution to become supersaturated and form Fc.gamma.RIIa crystals
at a constant temperature. Vapor diffusion is preferably performed
under a controlled temperature in the range of from about
15.degree. C. to about 30.degree. C., more preferably from about
20.degree. C. to about 25.degree. C., and more preferably at a
constant temperature of about 22.degree. C.
[0084] In a preferred embodiment, the present invention includes a
method to produce crystals of Fc.gamma.RIIa comprising the steps
of: (a) preparing an about 3 mg/ml solution of Fc.gamma.RIIa
protein in an acetate salt buffer to form a supersaturated
formulation, in which the buffer comprises about 200 mM ammonium
acetate, about 100 mM sodium citrate and about 30% PEG 4000 and has
a pH of about pH 5.8; (b) dropping about 3 .mu.l droplets of the
supersaturated formulation onto a coverslip and inverting this over
a well containing about 1 ml of the acetate salt buffer; and (c)
incubating until crystals of Fc.gamma.RIIa form.
[0085] In another preferred embodiment, the present invention
includes a method to produce crystals of Fc.gamma.RIIa comprising
the steps of: (a) preparing an about 3 mg/ml solution of
Fc.gamma.RIIa protein in a sulphate buffer to form a supersaturated
formulation, in which the buffer comprises about 0.15 M HEPES and
about 1.5 M lithium sulphate and has a pH of about pH 7.5; (b)
dropping about 3 .mu.l droplets of the supersaturated formulation
onto a coverslip and inverting this over a containing about 1 ml of
the sulphate buffer; and (c) incubating until crystals of
Fc.gamma.RIIa form.
[0086] As discussed briefly above, another embodiment of the
present invention is a method of producing Fc.epsilon.RI crystals
and the Fc.epsilon.RI crystals produced thereby. Preferably,
crystals of Fc.epsilon.RI are formed using a solution containing a
range of Fc.epsilon.RI protein from about 1 mg/ml to about 20
mg/ml, more preferably from about 2 mg/ml to about 15 mg/ml, and
even more preferably from about 3 mg/ml to about 6 mg/ml of
Fc.epsilon.RI protein in a mother liquor, with 3 mg/ml and 6 mg/ml
of Fc.epsilon.RI protein in a mother liquor being more preferred.
Preferably, crystals are formed using droplets containing from
about 1 .mu.g to about 30 .mu.g, more preferably from about 5 .mu.g
to about 25 .mu.g, and more preferably from about 4.5 .mu.g to
about 9 .mu.g of Fc.epsilon.RI protein per 3 .mu.l droplet.
[0087] A suitable mother liquor of the present invention comprises
an acetate salt buffer. A preferred acetate salt buffer of the
present invention comprises calcium acetate. The concentration of
calcium acetate in the buffer prior to crystallization can range
from about 100 mM to about 500 mM calcium acetate. Preferably, the
concentration of calcium acetate in the buffer ranges from about
150 mM to about 300 mM calcium acetate. More preferably, the
concentration of calcium acetate in the buffer is 200 mM calcium
acetate. A suitable acetate salt buffer preferably includes a
buffer having a pH of from about 5.5 to about 7.5, more preferably
from about 6.0 to about 7.0, and more preferably a pH of about 6.5.
Preferably, the pH of an acetate salt buffer or the present
invention is controlled using sodium cacodylate. A suitable acetate
salt buffer contains sodium cacodylate at a concentration of about
0.01 M sodium cacodylate, more preferably 0.05 M sodium cacodylate
and more preferably 0.1 M sodium cacodylate. A suitable acetate
salt buffer contains any polyethylene glycol (PEG), with PEG 8000
being more preferred. Suitable PEG 8000 concentrations in an
acetate salt buffer of the present invention include a
concentration of about 10% w/v, preferably about 15%, and more
preferably about 20% w/v PEG 8000.
[0088] Another suitable mother liquor of the present invention
comprises a buffer which includes sodium cacodylate together with
2-propanol and polyethylene glycol. A preferred sodium cacodylate
buffer of the present invention comprises a concentration of sodium
cacodylate in the buffer prior to crystallization of about 0.01 M
sodium cacodylate, more preferably 0.05 M sodium cacodylate and
more preferably 0.1 M sodium cacodylate. A suitable sodium
cacodylate buffer preferably includes a buffer having a pH of from
about 5 to about 7, more preferably from about 5.5 to about 6.5,
and more preferably a pH of from about 5.5 to about 6.0. A suitable
sodium cacodylate buffer contains 2-propanol at a concentration of
about 5% v/v, more preferably 7% v/v and more preferably 10% v/v. A
suitable sodium cacodylate buffer contains any polyethylene glycol
(PEG), with PEG 4000 being more preferred. Suitable PEG 4000
concentrations in an acetate salt buffer of the present invention
include a concentration of about 10% w/v, preferably about 15%, and
more preferably about 20% w/v PEG 4000.
[0089] Another suitable mother liquor of the present invention
comprises a sodium citrate buffer which includes tri sodium citrate
dihydrate together with sodium cacodylate and 2-propanol. A
preferred sodium citrate buffer of the present invention comprises
a concentration of tri sodium citrate dihydrate in the buffer prior
to crystallization of about 0.05 M tri sodium citrate dihydrate,
more preferably 0.1 M tri sodium citrate dihydrate and more
preferably 0.2 M tri sodium citrate dihydrate. A suitable sodium
citrate buffer preferably includes a buffer having a pH of from
about 5.5 to about 7, more preferably from about 6.0 to about 7.0,
and more preferably a pH of about 6.5. A preferred sodium citrate
buffer of the present invention comprises a concentration of sodium
cacodylate in the buffer prior to crystallization of about 0.01 M
sodium cacodylate, more preferably 0.05 M sodium cacodylate and
more preferably 0.1 M sodium cacodylate. A suitable sodium citrate
buffer contains 2-propanol at a concentration of about 15% v/v,
more preferably 20% v/v and more preferably 30% v/v.
[0090] Supersaturated solutions of Fc.epsilon.RI protein can be
induced to crystallize by several methods including, but not
limited to, vapor diffusion, liquid diffusion, batch
crystallization, constant temperature and temperature induction or
a combination thereof. Preferably, supersaturated solutions of
Fc.epsilon.RI protein are induced to crystallize by vapor diffusion
(i.e., hanging drop method). In a vapor diffusion method, an
Fc.epsilon.RI protein is combined with a mother liquor of the
present invention that will cause the Fc.epsilon.RI protein
solution to become supersaturated and form Fc.epsilon.RI crystals
at a constant temperature. Vapor diffusion is preferably performed
under a controlled temperature in the range of from about
15.degree. C. to about 30.degree. C., more preferably from about
20.degree. C. to about 25.degree. C., and more preferably at a
constant temperature of about 22.degree. C.
[0091] In a preferred embodiment, the present invention includes a
method to produce crystals of Fc.epsilon.RI comprising the steps
of: (a) preparing an about 3 mg/ml solution of Fc.epsilon.RI
protein in an acetate salt buffer to form a supersaturated
formulation, in which the buffer comprises about 200 mM calcium
acetate, about 100 mM sodium cacodylate and about 18% w/v PEG 8000
and has a pH of about pH 6.5; (b) dropping about 3 .mu.l droplets
of the supersaturated formulation onto a coverslip and inverting
this over a well containing about 1 ml of the acetate salt buffer;
and (c) incubating until crystals of Fc.epsilon.RI form.
[0092] In another preferred embodiment, the present invention
includes a method to produce crystals of Fc.epsilon.RI comprising
the steps of: (a) preparing an about 3 mg/ml solution of
Fc.epsilon.RI protein in a sodium cacodylate buffer to form a
supersaturated formulation, in which the buffer comprises about 100
mM sodium cacodylate, about 10% v/v 2-propanol and about 20% w/v
PEG 4000 and has a pH of about pH 5.5-6.0; (b) dropping about 3
.mu.l droplets of the supersaturated formulation onto a coverslip
and inverting this over a containing about 1 ml of the sulphate
buffer; and (c) incubating until crystals of Fc.epsilon.RI
form.
[0093] In another preferred embodiment, the present invention
includes a method to produce crystals of Fc.epsilon.RI comprising
the steps of: (a) preparing an about 3 mg/ml solution of
Fc.epsilon.RI protein in a sodium citrate buffer to form a
supersaturated formulation, in which the buffer comprises about 200
mM tri sodium citrate dihydrate, about 100 mM sodium cacodylate and
about 30% v/v 2-propanol and has a pH of about pH 6.5; (b) dropping
about 3 .mu.l droplets of the supersaturated formulation onto a
coverslip and inverting this over a containing about 1 ml of the
sulphate buffer; and (c) incubating until crystals of Fc.epsilon.RI
form.
[0094] Any isolated FcR protein can be used with the present
method. An isolated FcR protein can be isolated from its natural
milieu or produced using recombinant DNA technology (e.g.,
polymerase chain reaction (PCR) amplification, cloning) or chemical
synthesis. To produce recombinant FcR protein, a nucleic acid
molecule encoding FcR protein can be inserted into any vector
capable of delivering the nucleic acid molecule into a host cell.
Suitable and preferred nucleic acid molecules to include in
recombinant vectors of the present invention are as disclosed
herein. A preferred nucleic acid molecule of the present invention
encodes a human FcR protein, and more preferably, a human
Fc.gamma.RIIa protein, a human Fc.epsilon.RI protein, or a human
Fc.gamma.RIIIb protein. A nucleic acid molecule of the present
invention can encode any portion of an FcR protein, preferably a
full-length FcR protein, and more preferably a soluble form of FcR
protein (i.e., a form of FcR protein capable of being secreted by a
cell that produces such protein). A more preferred nucleic acid
molecule to include in a recombinant vector, and particularly in a
recombinant molecule, includes a nucleic acid molecule encoding a
protein having the amino acid sequence represented by SEQ ID NO:3,
SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9,
SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12, or SEQ ID NO:13. A
preferred nucleic acid molecule to include in a recombinant
molecule includes sFc.gamma.RIIa and sFc.epsilon.RI, the production
of which are described in the Examples section.
[0095] A recombinant vector of the present invention can be either
RNA or DNA, either prokaryotic or eukaryotic, and typically is a
virus or a plasmid. Preferably, a nucleic acid molecule encoding an
FcR protein is inserted into a vector comprising an expression
vector to form a recombinant molecule. As used herein, an
expression vector is a DNA or RNA vector that is capable of
transforming a host cell and of affecting expression of a specified
nucleic acid molecule. Expression vectors of the present invention
include any vectors that function (i.e., direct gene expression) in
recombinant cells of the present invention, including in bacterial,
fungal, endoparasite, insect, other animal, and plant cells.
Preferred expression vectors of the present invention direct
expression in insect cells. A more preferred expression vector of
the present invention comprises pVL1392 baculovirus shuttle
plasmid. A preferred recombinant molecule of the present invention
comprises pVL-sFc.gamma.RIIa(a), pVL-sFc.gamma.RIIa(b), and
pVL-sFc.epsilon.RI.
[0096] An expression vector of the present invention can be
transformed into any suitable host cell to form a recombinant cell.
A suitable host cell includes any cell capable of expressing a
nucleic acid molecule inserted into the expression vector. For
example, a prokaryotic expression vector can be transformed into a
bacterial host cell. A preferred host cell of the present invention
includes a cell capable of expressing a baculovirus, in particular
an insect cell, with Spodoptera frugiperda or Trichoplusia ni cells
being preferred. A preferred recombinant cell of the present
invention includes S.
frugiperda:pVL-sFc.gamma.RIIa(a)/pVL-sFc.gamma.RIIa(b) cells and S.
frugiperda:pVL-sFc.epsilon.RI the production of which is described
herein.
[0097] One method to isolate FcR protein useful for producing FcR
crystals includes recovery of recombinant proteins from cell
cultures of recombinant cells expressing such FcR protein. In one
embodiment, an isolated recombinant FcR protein of the present
invention is produced by culturing a cell capable of expressing the
protein under conditions effective to produce the protein, and
recovering the protein. A preferred cell to culture is a
recombinant cell of the present invention. Effective culture
conditions include, but are not limited to, effective media,
bioreactor, temperature, pH and oxygen conditions and culture
medium that permit protein production. Such culturing conditions
are within the expertise of one of ordinary skill in the art.
Examples of suitable conditions are included in the Examples
section.
[0098] Preferably, a recombinant cell of the present invention
expresses a secreted form of FcR protein. FcR proteins of the
present invention can be purified using a variety of standard
protein purification techniques, such as, but not limited to,
affinity chromatography, ion exchange chromatography, filtration,
electrophoresis, hydrophobic interaction chromatography, gel
filtration chromatography, reverse phase chromatography,
chromatofocusing and differential solubilization. Preferably, an
FcR protein is purified in such a manner that the protein is
purified sufficiently for formation of crystals useful for
obtaining information related to the three dimensional structure of
an FcR protein. Preferably, a composition of FcR protein is about
70%, more preferably 75%, more preferably 80%, more preferably 85%
and more preferably 90% pure.
[0099] In one embodiment, a recombinant FcR protein is purified
from a cell culture supernatant harvested between about 20 hours
and about 60 hours post-infection, preferably between about 30
hours and about 50 hours post-infection, and more preferably about
40 hours post-infection. Preferably, an Fc.gamma.RIIa protein is
purified from a supernatant by a method comprising the steps: (a)
applying supernatant from S.
frugiperda:pVL-sFc.gamma.RIIa(a)/pVL-sFc.gamma.RIIa(b) cells to an
ion exchange column; (b) collecting unbound protein from the ion
exchange column and applying the unbound protein to an
immuno-affinity chromatography column; (c) eluting proteins bound
to the immuno-affinity chromatography column and applying the
eluted proteins to a gel filtration column; and (d) collecting
filtered proteins from the gel filtration column to obtain the
Fc.gamma.RIIa protein. Preferably, an Fc.epsilon.RI protein is
purified from a supernatant by a method comprising the steps: (a)
applying supernatant from S. frugiperda:pVL-sFc.epsilon.RI cells to
an ion exchange column; (b) collecting unbound protein from the ion
exchange column and applying the unbound protein to an
immuno-affinity chromatography column; (c) eluting proteins bound
to the immuno-affinity chromatography column and applying the
eluted proteins to a gel filtration column; and (d) collecting
filtered proteins from the gel filtration column to obtain the
Fc.epsilon.RI protein.
[0100] In view of the high degree of amino acid sequence homology
between human Fc.gamma.R proteins and other members of the
Fc.gamma.R family of proteins, the methods of purification of the
present invention are applicable for each member of the Fc.gamma.R
family. In addition, one of skill in the art will recognize that
the purification methods of the present invention are generally
useful for purifying any FcR protein, such as the Fc.epsilon.RI
protein, except using IgE rather than IgG for the step of
immuno-affinity chromatography purification, and such as the
Fc.alpha.RI protein, except using IgA rather than IgG for the
purification step. Isolated protein of the members of the
Fc.gamma.R family of proteins, Fc.epsilon.R protein and Fc.alpha.R
protein may be obtained through recombinant DNA technology or may
be purified from natural sources, including but not limited to,
monocytes, macrophages, neutrophils, eosinophils, platelets and B
lymphocytes (i.e., B cells). Descriptions of recombinant production
of isolated Fc.gamma.RIIa and Fc.epsilon.RI proteins are described
in the Examples section.
[0101] Another embodiment of the present invention includes a
composition comprising FcR protein in a crystalline form (i.e., FcR
crystals). As used herein, the terms "crystalline FcR" and "FcR
crystal" both refer to crystallized FcR protein and are intended to
be used interchangeably. Preferably, a crystalline FcR is produced
using the crystal formation method described herein, in particular
according to the method disclosed in Example 6 or Example 9. A FcR
crystal of the present invention can comprise any crystal structure
and preferably precipitates as an orthorhombic crystal. A suitable
crystalline FcR of the present invention includes a monomer or a
multimer of FcR protein. A preferred crystalline FcR comprises one
FcR protein in an asymmetric unit. A more preferred crystalline FcR
comprises a dimer of FcR proteins.
[0102] A particular embodiment of the present invention includes a
composition comprising Fc.gamma.RIIa protein in a crystalline form
(i.e., Fc.gamma.RIIa crystals). As used herein, the terms
"crystalline Fc.gamma.RIIa" and "Fc.gamma.RIIa crystal" both refer
to crystallized Fc.gamma.RIIa protein and are intended to be used
interchangeably. Preferably, a crystal Fc.gamma.RIIa is produced
using the crystal formation method described herein, in particular
according to the method disclosed in Example 6. A Fc.gamma.RIIa
crystal of the present invention can comprise any crystal structure
and preferably precipitates as an orthorhombic crystal. Preferably,
a composition of the present invention includes Fc.gamma.RIIa
protein molecules arranged in a crystalline manner in a space group
P2.sub.12.sub.12, so as to form a unit cell of dimensions a=78.80
.ANG., b=100.55 .ANG., c=27.85 .ANG.. A preferred crystal of the
present invention provides X-ray diffraction data for determination
of atomic coordinates of the Fc.gamma.RIIa protein to a resolution
of about 3.0 .ANG., preferably about 2.4 .ANG., and more preferably
at about 1.8 .ANG..
[0103] A suitable crystalline Fc.gamma.RIIa of the present
invention includes a monomer or a multimer of Fc.gamma.RIIa
protein. A preferred crystalline Fc.gamma.RIIa comprises one
Fc.gamma.RIIa proteins in an asymmetric unit. A more preferred
crystalline Fc.gamma.RIIa comprises a dimer of Fc.gamma.RIIa
proteins.
[0104] Another particular embodiment of the present invention
includes a composition comprising Fc.epsilon.RI protein in a
crystalline form (i.e., Fc.epsilon.RI crystals). As used herein,
the terms "crystalline Fc.epsilon.RI" and "Fc.epsilon.RI crystal"
both refer to crystallized Fc.epsilon.RI protein and are intended
to be used interchangeably. Preferably, a crystal Fc.epsilon.RI is
produced using the crystal formation method described herein, in
particular according to the method disclosed in Example 9. A
Fc.epsilon.RI crystal of the present invention can comprise any
crystal structure and preferably precipitates as an orthorhombic
crystal. A suitable crystalline Fc.epsilon.RI of the present
invention includes a monomer or a multimer of Fc.epsilon.RI
protein. A preferred crystalline.Fc.epsilon.RI comprises one
Fc.epsilon.RI protein in an asymmetric unit. A more preferred
crystalline Fc.epsilon.RI comprises a dimer of Fc.epsilon.RI
proteins.
[0105] According to the present invention, crystalline FcR can be
used to determine the ability of a chemical compound of the present
invention to bind to Fc.gamma.RIIa protein a manner predicted by a
structure based drug design method of the present invention.
Preferably, an Fc.gamma.RIIa crystal is soaked in a solution
containing a chemical compound of the present invention. Binding of
the chemical compound to the crystal is then determined by methods
standard in the art.
[0106] One embodiment of the present invention is a therapeutic
composition. A therapeutic composition of the present invention
comprises one or more therapeutic compounds. Preferred therapeutic
compounds of the present invention include inhibitory compounds and
stimulatory compounds.
[0107] One embodiment of the present invention is a therapeutic
composition that is capable of reducing IgG-mediated tissue damage.
Suitable therapeutic compositions are capable of reducing
IgG-mediated tissue damage resulting from IgG-mediated
hypersensitivity or other biological mechanisms involved in
IgG-mediated recruitment of inflammatory cells that involves
Fc.gamma.R protein. For example, a therapeutic composition of the
present invention can: (1) inhibit (i.e., prevent, block) binding
of Fc.gamma.R protein on a cell having an Fc.gamma.R protein (e.g.,
B cells, macrophage, neutrophil, eosinophil or platelet cells) to
an IgG immune complex by interfering with the IgG binding site of
an Fc.gamma.R protein; (2) binding to the Fc portion of IgG to
inhibit complement fixation by an IgG immune complex by interfering
with the complement binding site of an IgG molecule; (3) inhibit
precipitation of IgG or IgG immune complexes (i.e., prevent Fc:Fc
interactions between two IgG); (4) inhibit immunoglobulin-mediated
cellular signal transduction by interfering with the binding of an
IgG to a cell surface receptor; (5) inhibit Fc.gamma.R-mediated
cellular signal transduction by interfering with the binding of a
cell signal inducing molecule (i.e., a molecule that induces
cellular signal transduction through an Fc.gamma.R protein) to an
Fc.gamma.R protein; (6) inhibit opsinization of pathogens by
inhibiting binding of IgG bound to a pathogen to Fc.gamma.R protein
on a phagocytic cell (e.g., to prevent antibody dependent
enhancement (ADE) of viral infection, such as with flaviviruses and
dengue virus); and (7) inhibit the binding of viral molecules to
Fc.gamma.R protein (e.g., measles virus nucleocapsid protein). As
used herein, the term "immune complex" refers to a complex that is
formed when an antibody binds to a soluble antigen. As used herein,
the term "complement fixation" refers to complement activation by
an antigen:antibody complex that results in recruitment of
inflammatory cells, typically by assembly of a complex comprising
C3a and C5a, or generation of cleaved C4. As used herein, the term
"binding site" refers to the region of a molecule (e.g., a protein)
to which another molecule specifically binds. Such therapeutic
compositions include one or more inhibitory compounds that inhibit
binding of IgG to Fc.gamma.R protein, IgG to complement, IgG to
IgG, IgG to a cell surface receptor, a cell signal inducing
molecule to Fc.gamma.R protein, Fc.gamma.R protein to virus or
inhibit opsinization. Also included in the present invention are
methods to reduce IgG-mediated tissue damage. The method includes
the step of administering to an animal a therapeutic composition of
the present invention.
[0108] Another embodiment of the present invention is a therapeutic
composition that is capable of stimulating an IgG humoral immune
response in an animal. Yet another embodiment of the present
invention is a therapeutic composition that improves the
therapeutic affects of an antibody that is administered to an
animal to treat, by opsinization or Fc.gamma.R-dependent effector
functions (e.g. antibody-dependent Fc.gamma.R-medicated
cytotoxicity, phagocytosis or release of cellular mediators), a
particular disease, including, but not limited to, cancer or
infectious disease (e.g. oral infections such as HIV, herpes,
bacterial infections, yeast infections or parasite infections).
Such a therapeutic composition includes one or more stimulatory
compounds that have increased binding to IgG, enhance binding of
IgG to Fc.gamma.R, enhance dimer formation of an Fc.gamma.R and/or
enhance signal transduction through the Fc.gamma.R. Also included
in the present invention is a method to stimulate a humoral immune
response. The method includes the step of administering to an
animal a therapeutic composition of the present invention.
[0109] Suitable inhibitory compounds of the present invention are
compounds that interact directly with an Fc.gamma.R protein,
preferably an Fc.gamma.RIIa protein or an Fc.gamma.RIIIb protein,
thereby inhibiting the binding of IgG to an Fc.gamma.R protein, by
either blocking the IgG binding site of an Fc.gamma.R (referred to
herein as substrate analogs) or by modifying other regions of the
Fc.gamma.R protein (such as in the upper groove of the IgG binding
cleft between the monomers of an Fc.gamma.R dimer, at the dimer
interface, in the cleft or hinge region between D1 and D2 on each
monomer, and/or underneath the IgG binding cleft in the lower
groove formed by the monomers of an Fc.gamma.R dimer) such that IgG
cannot bind to the Fc.gamma.R (e.g., by allosteric interaction). A
Fc.gamma.R substrate analog refers to a compound that interacts
with (e.g., binds to, associates with, modifies) the IgG binding
site of an Fc.gamma.R protein. A Fc.gamma.R substrate analog can,
for example, comprise a chemical compound that mimics the Fc
portion of an IgG, or that binds specifically to the IgG binding
site of an Fc.gamma.R but does not mimic the Fc portion of an IgG.
An inhibitory compound of the present invention can also include a
compound that essentially mimics at least a portion of an
Fc.gamma.RIIa protein that binds to IgG (referred to herein as a
peptidomimetic compound). Other suitable inhibitory compounds of
the present invention include compounds that inhibit the binding of
an Fc.gamma.R protein to a cell signal inducing molecule other than
IgG. Examples of such cell signal inducing molecules include
another Fc.gamma.R (i.e., to form a dimer of Fc.gamma.R proteins),
or a cell surface accessory molecule, an intracellular accessory
molecule or virus (e.g., measles virus nucleocapsid protein).
[0110] One embodiment of the present invention is a therapeutic
composition that is capable of reducing IgE-mediated responses.
Suitable therapeutic compositions are capable of reducing
IgE-mediated responses resulting from IgE-mediated
hypersensitivity, IgE-mediated release of inflammatory modulators
or other biological mechanisms involved in IgE-mediated recruitment
of inflammatory cells that involves Fc.epsilon.R protein. For
example, a therapeutic composition of the present invention can:
(1) inhibit (i.e., prevent, block) binding of Fc.epsilon.R protein
on a cell having an Fc.epsilon.R protein (e.g., mast cells) to an
IgE immune complex by interfering with the IgE binding site of an
Fc.epsilon.R protein; (2) inhibit precipitation of IgE or IgE
immune complexes (i.e., prevent Fc:Fc interactions between two
IgE); (3) inhibit immunoglobulin-mediated cellular signal
transduction by interfering with the binding of an IgE to a cell
surface receptor; and (4) inhibit Fc.epsilon.R-mediated cellular
signal transduction by interfering with the binding of a cell
signal inducing molecule (i.e., a molecule that induces cellular
signal transduction through an Fc.epsilon.R protein) to an
Fc.epsilon.R protein. Such therapeutic compositions include one or
more inhibitory compounds that inhibit binding of IgE to
Fc.epsilon.R protein, IgE to IgE, IgE to a cell surface receptor,
or a cell signal inducing molecule to Fc.epsilon.R protein. Also
included in the present invention are methods to reduce
IgE-mediated responses, such as IgE-mediated inflammation. The
method includes the step of administering to an animal a
therapeutic composition of the present invention.
[0111] Another embodiment of the present invention is a therapeutic
composition that is capable of stimulating a IgE humoral immune
response in an animal. Yet another embodiment of the present
invention is a therapeutic composition that improves the
therapeutic affects of an antibody that is administered to an
animal to treat, by opsinization or Fc.epsilon.R-dependent effector
functions (e.g. phagocytosis or release of cellular mediators), a
particular disease. Such a therapeutic composition includes one or
more stimulatory compounds that have increased binding to IgE,
enhance binding of IgE to Fc.epsilon.RI, enhance dimer formation of
Fc.epsilon.RI and/or otherwise enhance signal transduction through
the Fc.epsilon.RI. Also included in the present invention is a
method to stimulate a humoral immune response. The method includes
the step of administering to an animal a therapeutic composition of
the present invention.
[0112] Suitable inhibitory compounds of the present invention are
compounds that interact directly with an Fc.epsilon.R protein,
thereby inhibiting the binding of IgE to an Fc.epsilon.R protein,
by either blocking the IgE binding site of an Fc.epsilon.R
(referred to herein as substrate analogs) or by modifying other
regions of the Fc.epsilon.R protein (such as in the upper groove of
the IgE binding cleft between the monomers of an Fc.epsilon.RI
dimer, at the dimer interface, in the cleft or hinge region between
D1 and D2 on each monomer, and/or underneath the IgE binding cleft
in the lower groove formed by the monomers of an Fc.epsilon.RI
dimer) such that IgE cannot bind to the Fc.epsilon.R (e.g., by
allosteric interaction). A Fc.epsilon.R substrate analog refers to
a compound that interacts with (e.g., binds to, associates with,
modifies) the IgE binding site of an Fc.epsilon.R protein. A
Fc.epsilon.R substrate analog can, for example, comprise a chemical
compound that mimics the Fc portion of an IgE, or that binds
specifically to the IgE binding site of an Fc.epsilon.R but does
not mimic the Fc portion of an IgE. An inhibitory compound of the
present invention can also include a compound that essentially
mimics at least a portion of an Fc.epsilon.R protein that binds to
IgE (referred to herein as a peptidomimetic compound). Other
suitable inhibitory compounds of the present invention include
compounds that inhibit the binding of an Fc.epsilon.R protein to a
cell signal inducing molecule other than IgE. Examples of such cell
signal inducing molecules include another Fc.epsilon.R (i.e., to
form a dimer of Fc.epsilon.R proteins), or a cell surface accessory
molecule, an intracellular accessory molecule or virus (e.g.,
measles virus nucleocapsid protein).
[0113] Inhibitory compounds of the present invention can be
identified by various means known to those of skill in the art. For
example, binding of an inhibitory compound to, or otherwise
interaction with, an FcR protein, can be determined with FcR
protein in solution or on cells using, for example, immunoassays
such as enzyme linked immunoabsorbent assays (ELISA) and
radioimmunoassays (RIA) or binding assays such as Biacore assays.
Cell-based assays can include, for example, cytokine (e.g., IL-4,
IL-6 or IL-12) secretion assays, or intracellular signal
transduction assays that determine, for example, protein or lipid
phosphorylation, mediator release or intracellular Ca.sup.++
mobilization upon FcR binding to a cell signal inducing
molecule.
[0114] Suitable stimulatory therapeutic compounds of the present
invention are compounds that exhibit improved binding to Ig when
compared with the ability of a natural FcR protein (e.g., an FcR
protein isolated from its natural milieu) to bind to Ig, and also
include compounds that enhance the binding of Ig to its FcR or
enhance signal transduction through the FcR. Stimulatory compounds
of the present invention are identified by their ability to: (1)
bind to, or otherwise interact with, Ig at a higher level than, for
example, natural FcR protein; (2) enhance binding of Ig to its FcR;
(3) enhance dimer formation of an FcR by binding either to the FcR,
to an Ig that binds to the FcR or to the combination of Ig bound to
the FcR; and/or (4) enhance signal transduction through the FcR.
Methods to determine improved binding of Ig to a stimulatory
compound of the present invention compared with, for example,
natural FcR protein, include binding assays that determine the
stability of binding, affinity or kinetics at which an Ig binds to
a stimulatory compound and a natural FcR protein. Such methods are
well known to those of skill in the art and are disclosed herein in
the Examples section. A stimulatory compound of the present
invention can also include a compound that binds to an Ig or an FcR
protein, thereby enhancing the binding of Ig to FcR protein or
improving cellular signal transduction during or after the binding
of Ig to FcR protein, by, for example, modifying other regions of
the FcR or Ig by an allosteric interaction that modifies the
Ig-binding site of FcR or the Fc portion of Ig that binds to an FcR
protein. Another stimulatory compound of the present invention can
include a compound that binds to FcR protein in the absence of Ig,
in such a manner that FcR-mediated cellular signal transduction is
stimulated.
[0115] One of skill in the art will understand that inhibitory or
stimulatory compounds can also be developed based on the structure
of any FcR and its Ig ligand, as described above for Fc.gamma.R
protein and IgG and Fc.epsilon.RI and IgE.
[0116] According to the present invention, suitable therapeutic
compounds of the present invention include peptides or other
organic molecules, and inorganic molecules. Suitable organic
molecules include small organic molecules. Preferably, a
therapeutic compound of the present invention is not harmful (e.g.,
toxic) to an animal when such compound is administered to an
animal. Peptides refer to a class of compounds that is small in
molecular weight and yields two or more amino acids upon
hydrolysis. A polypeptide is comprised of two or more peptides. As
used herein, a protein is comprised of one or more polypeptides.
Preferred therapeutic compounds to design include peptides composed
of "L" and/or "D" amino acids that are configured as normal or
retroinverso peptides, peptidomimetic compounds, small organic
molecules, or homo- or hetero-polymers thereof, in linear or
branched configurations.
[0117] Therapeutic compounds of the present invention can be
designed using structure based drug design. Until the discovery of
the three dimensional structure of the present invention, no
information was available for structure based development of
therapeutic compounds based on the structure of FcR protein. Such
rational development heretofore could not be executed de novo from
available linear amino acid sequence information. Structure based
drug design refers to the use of computer simulation to predict a
conformation of a peptide, polypeptide, protein, or conformational
interaction between a peptide or polypeptide, and a therapeutic
compound. For example, generally, for a protein to effectively
interact with a therapeutic compound, it is necessary that the
three dimensional structure of the therapeutic compound assume a
compatible conformation that allows the compound to bind to the
protein in such a manner that a desired result is obtained upon
binding. Knowledge of the three dimensional structure of the
protein enables a skilled artisan to design a therapeutic compound
having such compatible conformation. For example, knowledge of the
three dimensional structure of the IgG binding site of
Fc.gamma.RIIa protein enables one of skill in the art to design a
therapeutic compound that binds to Fc.gamma.RIIa, is stable and
results in inhibition of a biological response such as IgG binding
to cells having Fc.gamma.R, or cellular signal transduction, upon
such binding. In addition, for example, knowledge of the three
dimensional structure of the IgG binding site of Fc.gamma.RIIa
protein enables a skilled artisan to design a substrate analog of
Fc.gamma.RIIa protein.
[0118] Suitable structures and models useful for structure based
drug design are disclosed herein. Preferred structures to use in a
method of structure based drug design include a structure of
Fc.gamma.RIIa protein, a structure of Fc.epsilon.RI protein, a
structure of an Fc.gamma.RIIIb protein, and a model of a target FcR
structure. Preferred models of target structures to use in a method
of structure based drug design include models produced by any
modeling method disclosed herein, including molecular replacement
and fold recognition related methods.
[0119] One embodiment of the present invention is a
computer-assisted method of structure based drug design of
bioactive compounds, comprising: (a) providing a structure of a
protein including a three dimensional structure of an FcR protein
or a model of the present invention; (b) designing a chemical
compound using the three dimensional structure or model; and (c)
chemically synthesizing the chemical compound. Such a method can
additionally include the step of (d) evaluating the bioactivity of
the synthesized chemical compound. Suitable three dimensional
structures an FcR protein and models to use with the present method
are disclosed herein. According to the present invention, the step
of designing can include creating a new chemical compound or
searching databases of libraries of known compounds (e.g., a
compound listed in a computational screening database containing
three dimensional structures of known compounds). Designing can
also be performed by simulating chemical compounds having
substitute moieties at certain structural features. The step of
designing can include selecting a chemical compound based on a
known function of the compound. A preferred step of designing
comprises computational screening of one or more databases of
compounds in which the three dimensional structure of the compound
is known and is interacted (e.g., docked, aligned, matched,
interfaced) with the three dimensional structure of an FcR protein
by computer (e.g. as described by Humblet and Dunbar, Animal
Reports in Medicinal Chemistry, vol. 28, pp. 275-283, 1993, M
Venuti, ed., Academic Press). Methods to synthesize suitable
chemical compounds are known to those of skill in the art and
depend upon the structure of the chemical being synthesized.
Methods to evaluate the bioactivity of the synthesized compound
depend upon the bioactivity of the compound (e.g., inhibitory or
stimulatory) and are disclosed herein.
[0120] Various other methods of structure-based drug design are
disclosed in Maulik et al., 1997, Molecular Biotechnology:
Therapeutic Applications and Strategies, Wiley-Liss, Inc., which is
incorporated herein by reference in its entirety. Maulik et al.
disclose, for example, methods of directed design, in which the
user directs the process of creating novel molecules from a
fragment library of appropriately selected fragments; random
design, in which the user uses a genetic or other algorithm to
randomly mutate fragments and their combinations while
simultaneously applying a selection criterion to evaluate the
fitness of candidate ligands; and a grid-based approach in which
the user calculates the interaction energy between three
dimensional receptor structures and small fragment probes, followed
by linking together of favorable probe sites.
[0121] Preferably, a chemical compound of the present invention
that binds to the Ig binding site of an FcR protein is known to
originate from a chemical compound having chemical and/or
stereochemical complementarity with FcR protein and/or Ig. Such
complementarity is characteristic of a chemical compound that
matches the surface of the receptor either in shape or in
distribution of chemical groups and binds to FcR protein to promote
or inhibit Ig binding to the FcR protein, or to induce cellular
signal transduction upon binding to FcR protein. More preferably, a
chemical compound that binds to the Ig binding site of an FcR
protein associates with an affinity of at least about 10.sup.-6 M,
and more preferably with an affinity of at least about 10.sup.-8
M.
[0122] Preferably, five sites of FcR protein are targets for
structure based drug design. These sites include the Ig-binding
site of FcR protein, the upper groove between two FcR monomers, the
dimerization interface between two FcR protein monomers, the lower
groove between two FcR monomers, the interface, cleft or hinge
region between Domains 1 and 2 of FcR protein, and combinations of
any of these sites (e.g., interacting with the Ig-binding site and
the upper groove between monomers simultaneously). A schematic
representation of these sites is shown in FIG. 17, with "a"
representing the Ig-binding site of FcR protein, "b" representing
the upper groove between two FcR monomers, "c" representing the
dimerization interface between two FcR protein monomers, "d"
representing the interface, cleft or hinge region between Domains 1
and 2 of FcR protein, and "e" representing the lower groove between
two FcR monomers. The following discussion provides specific detail
on drug-design using target sites of the FcR and as an example,
references preferred target sites on the Fc.gamma.RIIa structure.
It is to be understood, however, that one of skill in the art,
using the description of the Fc.epsilon.RI structure and the
Fc.gamma.RIIIb structure provided herein, will be able to
effectively select similar target sites on the Fc.epsilon.RI
protein monomer and dimer for structure based drug design.
Additionally, one of skill in the art, now being able to model the
other FcR proteins based on the information provided herein, will
also be able to effectively select similar target sites on the
other FcR proteins for structure based drug design.
[0123] The Ig-binding site (FIG. 17; "a") is targeted to directly
affect the binding of FcR to Ig (i.e., inhibition or enhancement).
The IgG binding site of Fc.gamma.RIIa protein, for example,
includes, but is not limited to, residues 155, 156, 158-160,
113-116, 129, 131, 133 and 134 of SEQ ID NO:3, and can also include
at least a portion of the second site described above (FIG. 17;
"b"), the groove between the two IgG binding sites that form upon
dimerization of Fc.gamma.RIIa protein. Residues from site "b" that
are included in IgG binding include, but are not limited to,
residues 117-121, 125-129, 150-154 and 157-161 of SEQ ID NO:3. A
suitable target site for structure based drug design comprising the
IgG binding site of Fc.gamma.RIIa protein is illustrated in FIG. 7.
More specifically, mutagenesis studies have identified several
residues which have an effect on the binding of IgG, and the three
dimensional structure disclosed herein clearly identifies which
residues are surface exposed (i.e., are likely to participate in
binding of IgG and are not just having an allosteric effect). These
residues can be classified in three spatial groups: (1) Phe129,
His131, Lys113, Pro114, Leu115, Val116; (2) Pro134 and Asp133; and
(3) Leu159 and Ser161. Group (1) forms a continuous surface leading
from the lip of the groove "b" (FIG. 17) across the binding surface
"a" (FIG. 17), and represents the most preferred target of design
work at the site of IgG binding. Group (2) is separated from Group
(1) by Leu132, which is currently of unknown importance in the
binding of IgG, and may well be part of the surface exposed
residues. Group (3) contains residues which are remote from the
other two groups and do not appear to be available to participate
in binding of the IgG by the dimer structure.
[0124] The upper groove between the two monomers of the FcR (FIG.
17; "b") is also targeted to directly affect the binding of FcR to
Ig (i.e., inhibition or enhancement). The upper groove provides an
attractive site to build into in contrast to targeting a flat
protein surface. The dimer structure of the Fc.gamma.RIIa protein
suggests targeting C2 or pseudo C2 symmetric inhibitors. Preferred
residues to target in the Fc.gamma.RIIa protein include Lys117,
His131, Phe129, Asn154, Ser161, Leu159, Thr152 and Phe121, with
Phe129, Lys117 and His131 being most preferred. In one embodiment,
compounds can be designed which interact with both the upper groove
"b" and the IgG binding surface "a" simultaneously. For example,
improved Ig regulatory compounds may be obtained by designing
regulatory compounds which flow out of the groove and bind to the
binding surface of "a" as described above. Alternatively, a
regulatory compound which binds to "b" may sterically hinder
binding of IgG to "a" without actually interacting with the "a"
binding surface.
[0125] The receptor dimer interface (FIG. 17; "c") is targeted to
directly affect the ability of two FcR proteins to form a dimer,
thereby affecting cellular signal transduction through one or both
of the FcR proteins. Without being bound by theory, the present
inventors believe that dimer formation can affect cellular signal
transduction or affect the conformation of the Ig binding of one or
both of the FcR proteins involved in the dimer, thereby affecting
cellular signal transduction. In addition, the dimer interface
represents an excellent target site because one monomer provides
ligand information for the other monomer and vice versa. A suitable
target site for structure based drug design comprising the
dimerization interface between two Fc.gamma.RIIa proteins is
illustrated in FIG. 10. More specifically, residues 117-131 and
residues 150-164 make up the interfacial area of the Fc.gamma.RIIa
dimer, and peptides from these sequences or their mimics may be
binding inhibitors. An examination of hydrogen bonding interactions
from the crystal structure of Fc.gamma.RIIa indicates relatively
few interactions between the monomers in the interfacial area, but
a notable cluster is spanned by the hexapeptide
Phe121-Gln122-Asn123-Gly124-Lys125-Ser126. Additionally, there is a
hydrogen bond between the monomers involving Gly124-Ser561 and
Ser126-Leu559. There are also some hydrophobic contacts made by the
Lys125 sidechain and by the Phe121 phenyl ring.
[0126] The interface between Domains 1 and 2 (FIG. 17; "d") is
targeted to affect IgG binding to an Fc.gamma.RIIa protein. The
present inventors have discovered that in the three dimensional
structure of Fc.gamma.RIIa protein, Domain 1 makes close contact
with Domain 2. In particular, a loop comprising residues 17-20 of
SEQ ID NO:3 in Domain 1 lie close to the loops of Domain 2 to form
at least a portion of the IgG-binding site. Interactions with IgG
are believed to occur close to the D1D2 interface and so
alterations at this site may effect Ig binding. Additionally, a
cleft is defined by residues 12-14 (base), 6-10 and 77-80 (D1 face)
and 93-96 and 101 (D2 face), and as such represents a potential
site for inhibitor design. A suitable target site for structure
based drug design comprising the interface between Domain 1 and
Domain 2 of an Fc.gamma.RIIa protein is illustrated in FIG. 5.
[0127] The lower groove between the two monomers of the FcR (FIG.
17; "e") is also targeted to directly affect the binding of FcR to
Ig (i.e., inhibition or enhancement). A similar design strategy can
be used for this site as described above for the upper groove "b",
although it is less clear whether compounds binding to this site
would be inhibitory, or more probably enhance IgG binding to the
Fc.gamma.R.
[0128] Drug design strategies as specifically described above with
regard to residues and regions of the Fc.gamma.RIIa monomer and
dimer can be similarly applied to the other FcR structures,
including the Fc.gamma.RIIIb and Fc.epsilon.RI structures disclosed
herein. One of ordinary skill in the art, using the art recognized
modeling programs and drug design methods, many of which are
described herein, will be able to modify the Fc.gamma.RIIa design
strategy according to differences in amino acid sequence and more
favored structures, for example, in the other FcR, to similarly
design compounds which regulate other FcR action. In addition, one
of skill in the art could use lead compound structures derived from
one FcR, such as the Fc.gamma.RIIa protein, and taking into account
differences in amino acid residues in another FcR protein, such as
Fc.epsilon.RI, modify the Fc.gamma.RIIa lead compound to design
lead compound structures for regulation of the Fc.epsilon.RI
protein. For example, His131>Tyr131 in the upper groove
pharmacophore could be accommodated by changing an acidic moiety in
an Fc.gamma.RIIa lead compound structure to an electron deficient
ketone moiety.
[0129] In the present method of structure based drug design, it is
not necessary to align a candidate chemical compound (i.e., a
chemical compound being analyzed in, for example, a computational
screening method of the present invention) to each residue in a
target site. Suitable candidate chemical compounds can align to a
subset of residues described for a target site. Preferably, a
candidate chemical compound comprises a conformation that promotes
the formation of covalent or noncovalent crosslinking between the
target site and the candidate chemical compound. Preferably, a
candidate chemical compound binds to a surface adjacent to a target
site to provide an additional site of interaction in a complex.
When designing an antagonist (i.e., a chemical compound that
inhibits the binding of a ligand to FcR protein by blocking a
binding site or interface), the antagonist should bind with
sufficient affinity to the binding site or to substantially
prohibit a ligand (i.e., a molecule that specifically binds to the
target site) from binding to a target area. It will be appreciated
by one of skill in the art that it is not necessary that the
complementarity between a candidate chemical compound and a target
site extend over all residues specified here in order to inhibit or
promote binding of a ligand.
[0130] In general, the design of a chemical compound possessing
stereochemical complementarity can be accomplished by means of
techniques that optimize, chemically or geometrically, the "fit"
between a chemical compound and a target site. Such techniques are
disclosed by, for example, Sheridan and Venkataraghavan, Acc. Chem
Res., vol. 20, p. 322, 1987: Goodford, J. Med. Chem., vol. 27, p.
557, 1984; Beddell, Chem. Soc. Reviews, vol. 279, 1985; Hol, Angew.
Chem., vol. 25, p. 767, 1986; and Verlinde and Hol, Structure, vol.
2, p. 577, 1994, each of which are incorporated by this reference
herein in their entirety.
[0131] One embodiment of the present invention for structure based
drug design comprises identifying a chemical compound that
complements the shape of an FcR protein or a structure that is
related to an FcR protein. Such method is referred to herein as a
"geometric approach". In a geometric approach of the present
invention, the number of internal degrees of freedom (and the
corresponding local minima in the molecular conformation space) is
reduced by considering only the geometric (hard-sphere)
interactions of two rigid bodies, where one body (the active site)
contains "pockets" or "grooves" that form binding sites for the
second body (the complementing molecule, such as a ligand).
[0132] The geometric approach is described by Kuntz et al., J. Mol.
Biol., vol. 161, p. 269, 1982, which is incorporated by this
reference herein in its entirety. The algorithm for chemical
compound design can be implemented using the software program DOCK
Package, Version 1.0 (available from the Regents of the University
of California). Pursuant to the Kuntz algorithm, the shape of the
cavity or groove on the surface of a structure (e.g., Fc.gamma.RIIa
protein) at a binding site or interface is defined as a series of
overlapping spheres of different radii. One or more extant
databases of crystallographic data (e.g., the Cambridge Structural
Database System maintained by University Chemical Laboratory,
Cambridge University, Lensfield Road, Cambridge CB2 lEW, U.K.) or
the Protein Data Bank maintained by Brookhaven National Laboratory,
is then searched for chemical compounds that approximate the shape
thus defined.
[0133] Chemical compounds identified by the geometric approach can
be modified to satisfy criteria associated with chemical
complementarity, such as hydrogen bonding, ionic interactions or
Van der Waals interactions.
[0134] Another embodiment of the present invention for structure
based drug design comprises determining the interaction of chemical
groups ("probes") with an active site at sample positions within
and around a binding site or interface, resulting in an array of
energy values from which three dimensional contour surfaces at
selected energy levels can be generated. This method is referred to
herein as a "chemical-probe approach." The chemical-probe approach
to the design of a chemical compound of the present invention is
described by, for example, Goodford, J. Med. Chem., vol. 28, p.
849, 1985, which is incorporated by this reference herein in its
entirety, and is implemented using an appropriate software package,
including for example, GRID (available from Molecular Discovery
Ltd., Oxford OX2 9LL, U.K.). The chemical prerequisites for a
site-complementing molecule can be identified at the outset, by
probing the active site of an Fc.gamma.RIIa protein, for example,
(as represented by the atomic coordinates shown in Table 1) with
different chemical probes, e.g., water, a methyl group, an amine
nitrogen, a carboxyl oxygen and/or a hydroxyl. Preferred sites for
interaction between an active site and a probe are determined.
Putative complementary chemical compounds can be generated using
the resulting three dimensional pattern of such sites.
[0135] A therapeutic composition of the present invention can
comprise one or more therapeutic compounds of the present
invention. A therapeutic composition can further comprise other
compounds capable of reducing Ig-mediated responses or increasing a
humoral immune response. For example, a therapeutic composition of
the present invention useful for reducing tissue damage can also
include compounds that block recruitment of inflammatory cells,
such as by, for example, blocking complement fixation,
extravasation, block binding of viral proteins to FcR, block
opsinization or enhance normal and passive antibody immunity. A
therapeutic composition of the present invention useful for
reducing Ig-mediated inflammation can include compounds that block
recruitment of inflammatory cells and/or block signal transduction
pathway which leads to the release of inflammatory mediators.
[0136] A therapeutic composition of the present invention useful
for increasing a humoral response can also include compounds that
increase antibody production against an antigen (i.e., adjuvants),
including, but not limited to, cytokines, chemokines, and compounds
that induce the production of cytokines and chemokines (e.g.,
granulocyte macrophage colony stimulating factor (GM-CSF),
granulocyte colony stimulating factor (G-CSF), macrophage colony
stimulating factor (M-CSF), colony stimulating factor (CSF),
erythropoietin (EPO), interleukin 2 (IL-2), interleukin-3 (IL-3),
interleukin 4 (IL-4), interleukin 5 (IL-5), interleukin 6 (IL-6),
interleukin 7 (IL-7), interleukin 8 (IL-8), interleukin 10 (IL-10),
interleukin 12 (IL-12), interferon gamma, interferon gamma inducing
factor I (IGIF), transforming growth factor beta, RANTES (regulated
upon activation, normal T cell expressed and presumably secreted),
macrophage inflammatory proteins (e.g., MIP-1 alpha and MIP-1
beta), bacterial components (e.g., endotoxins, in particular
superantigens, exotoxins and cell wall components); aluminum-based
salts; calcium-based salts; silica; polynucleotides; toxoids; serum
proteins, viral coat proteins; block copolymer adjuvants (e.g.,
Hunter's Titermax.TM. adjuvant (Vaxce.TM., Inc. Norcross, Ga.),
Ribi adjuvants (Ribi ImmunoChem Research, Inc., Hamilton, Mont.);
and saponins and their derivatives (e.g., Quil A (Superfos
Biosector A/S, Denmark).
[0137] A therapeutic composition of the present invention can be
used to treat disease in an animal by administering such
composition to an animal in such a manner that desired therapeutic
results are obtained. Preferred animals to treat include mammals,
marsupials, reptiles and birds, with humans, companion animals,
food animals, zoo animals and other economically relevant animals
(e.g., race horses and animals valued for their coats, such as
chinchillas and minks). More preferred animals to treat include
humans, dogs, cats, horses, cattle, sheep, swine, chickens,
ostriches, emus, turkeys, koalas and kangaroos. Particularly
preferred animals to protect are humans, dogs and cats.
[0138] A preferred therapeutic composition of the present invention
also includes an excipient, an adjuvant and/or carrier. Suitable
excipients include compounds that the animal to be treated can
tolerate. Examples of such excipients include water, saline,
Ringer's solution, dextrose solution, Hank's solution, and other
aqueous physiologically balanced salt solutions. Nonaqueous
vehicles, such as fixed oils, sesame oil, ethyl oleate, or
triglycerides may also be used. Other useful formulations include
suspensions containing viscosity enhancing agents, such as sodium
carboxymethylcellulose, sorbitol, or dextran. Excipients can also
contain minor amounts of additives, such as substances that enhance
isotonicity and chemical stability. Examples of buffers include
phosphate buffer, bicarbonate buffer and Tris buffer, while
examples of preservatives include thimerosal, o-cresol, formalin
and benzyl alcohol. Standard formulations can either be liquid
injectables or solids which can be taken up in a suitable liquid as
a suspension or solution for injection. Thus, in a non-liquid
formulation, the excipient can comprise dextrose, human serum
albumin, preservatives, etc., to which sterile water or saline can
be added prior to administration.
[0139] In one embodiment of the present invention, a therapeutic
composition can include a carrier. Carriers include compounds that
increase the half-life of a therapeutic composition in the treated
animal. Suitable carriers include, but are not limited to,
polymeric controlled release vehicles, biodegradable implants,
liposomes, bacteria, viruses, other cells, oils, esters, and
glycols.
[0140] Acceptable protocols to administer therapeutic compositions
of the present invention in an effective manner include individual
dose size, number of doses, frequency of dose administration, and
mode of administration. Determination of such protocols can be
accomplished by those skilled in the art. Modes of administration
can include, but are not limited to, subcutaneous, intradermal,
intravenous, intranasal, oral, transdermal, intraocular and
intramuscular routes.
[0141] Another embodiment of the present invention are diagnostic
compounds capable of detecting altered FcR protein on or isolated
from cells obtained from patients having abnormal immunity or
inflammation. Using the methods of structure based drug design
described herein, diagnostic reagents that bind to FcR protein can
be developed using the three dimensional structure of FcR protein.
Preferred diagnostic reagents of the present invention include
molecules capable of binding to the Ig binding site of an FcR
protein capable of binding to Ig and molecules capable of binding
to circulating FcR protein obtained from patients with
inflammation. Preferred diagnostic reagents include molecules that
are immunogenic or can be chemically coupled to detectable
compounds, such as radioisotopes, enzymes, dyes or biotin.
[0142] In a preferred embodiment, a therapeutic compound or
diagnostic compound of the present invention comprises a protein
engineered by recombinant DNA methods.
1TABLE 1 REMARK Latest coordinates of the Fc Gamma Receptor IIa
structure REMARK Written by O version 5.10.1 REMARK Wed May 20
10:23:51 1998 CRYST1 79.221 100.866 28.172 90.00 90.00 90.00 ORIGX1
1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000
0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1
0.012623 0.000000 0.000000 0.00000 SCALE2 0.000000 0.009914
0.000000 0.00000 SCALE3 0.000000 0.000000 0.035496 0.00000 ATOM 1
CB ALA 1 36.645 68.826 -4.702 1.00 51.37 6 ATOM 2 C ALA 1 36.199
68.294 -2.285 1.00 42.22 6 ATOM 3 O ALA 1 36.801 67.492 -1.569 1.00
42.70 8 ATOM 4 N ALA 1 34.367 68.121 -3.997 1.00 45.74 7 ATOM 5 CA
ALA 1 35.829 67.992 -3.724 1.00 43.68 6 ATOM 6 N PRO 2 35.903
69.499 -1.817 1.00 40.54 7 ATOM 7 CD PRO 2 35.149 70.546 -2.533
1.00 38.91 6 ATOM 8 CA PRO 2 36.172 69.844 -0.425 1.00 38.61 6 ATOM
9 CB PRO 2 35.765 71.300 -0.322 1.00 39.86 6 ATOM 10 CG PRO 2
34.790 71.513 -1.426 1.00 41.36 6 ATOM 11 C PRO 2 35.294 68.931
0.434 1.00 36.70 6 ATOM 12 O PRO 2 34.188 68.654 -0.042 1.00 32.46
8 ATOM 13 N PRO 3 35.789 68.496 1.579 1.00 33.82 7 ATOM 14 CD PRO 3
37.120 68.857 2.110 1.00 35.16 6 ATOM 15 CA PRO 3 35.069 67.637
2.491 1.00 38.25 6 ATOM 16 CB PRO 3 35.872 67.639 3.799 1.00 37.39
6 ATOM 17 CG PRO 3 37.180 68.267 3.486 1.00 37.41 6 ATOM 18 C PRO 3
33.653 68.136 2.790 1.00 37.48 6 ATOM 19 O PRO 3 33.393 69.335
2.683 1.00 34.39 8 ATOM 20 N LYS 4 32.763 67.212 3.173 1.00 37.04 7
ATOM 21 CA LYS 4 31.399 67.678 3.424 1.00 34.97 6 ATOM 22 CB LYS 4
30.318 66.664 3.122 1.00 43.98 6 ATOM 23 CG LYS 4 30.564 65.191
3.278 1.00 47.64 6 ATOM 24 CD LYS 4 29.775 64.349 2.292 1.00 52.03
6 ATOM 25 CE LYS 4 28.317 64.743 2.137 1.00 57.56 6 ATOM 26 NZ LYS
4 27.724 64.253 0.855 1.00 56.40 7 ATOM 27 C LYS 4 31.243 68.234
4.825 1.00 31.44 6 ATOM 28 O LYS 4 31.846 67.769 5.784 1.00 29.91 8
ATOM 29 N ALA 5 30.416 69.280 4.908 1.00 28.75 7 ATOM 30 CA ALA 5
30.039 69.813 6.218 1.00 27.21 6 ATOM 31 CB ALA 5 29.155 71.032
6.110 1.00 21.94 6 ATOM 32 C ALA 5 29.278 68.683 6.923 1.00 26.42 6
ATOM 33 O ALA 5 28.760 67.794 6.222 1.00 26.10 8 ATOM 34 N VAL 6
29.231 68.674 8.241 1.00 24.91 7 ATOM 35 CA VAL 6 28.515 67.632
8.985 1.00 26.95 6 ATOM 36 CB VAL 6 29.490 66.738 9.770 1.00 29.36
6 ATOM 37 CG1 VAL 6 28.779 65.726 10.676 1.00 29.86 6 ATOM 38 CG2
VAL 6 30.434 66.024 8.801 1.00 26.74 6 ATOM 39 C VAL 6 27.503
68.253 9.942 1.00 28.93 6 ATOM 40 O VAL 6 27.846 68.994 10.866 1.00
31.46 8 ATOM 41 N LEU 7 26.233 67.929 9.758 1.00 30.08 7 ATOM 42 CA
LEU 7 25.105 68.383 10.546 1.00 29.33 6 ATOM 43 CB LEU 7 23.839
68.346 9.657 1.00 33.18 6 ATOM 44 CG LEU 7 22.828 69.458 9.960 1.00
34.94 6 ATOM 45 CD1 LEU 7 22.082 69.876 8.721 1.00 27.55 6 ATOM 46
CD2 LEU 7 21.887 69.002 11.069 1.00 32.30 6 ATOM 47 C LEU 7 24.816
67.565 11.794 1.00 29.57 6 ATOM 48 O LEU 7 24.653 66.351 11.800
1.00 30.04 8 ATOM 49 N LYS 8 24.768 68.242 12.930 1.00 28.04 7 ATOM
50 CA LYS 8 24.568 67.692 14.257 1.00 25.12 6 ATOM 51 CB LYS 8
25.738 68.179 15.132 1.00 33.32 6 ATOM 52 CG LYS 8 25.777 67.611
16.532 1.00 39.37 6 ATOM 53 CD LYS 8 25.967 68.598 17.652 1.00
43.84 6 ATOM 54 CE LYS 8 27.129 69.561 17.487 1.00 47.78 6 ATOM 55
NZ LYS 8 27.525 70.175 18.793 1.00 48.98 7 ATOM 56 C LYS 8 23.233
68.192 14.797 1.00 24.53 6 ATOM 57 O LYS 8 22.934 69.384 14.739
1.00 25.35 8 ATOM 58 N LEU 9 22.423 67.310 15.333 1.00 24.78 7 ATOM
59 CA LEU 9 21.080 67.553 15.843 1.00 22.07 6 ATOM 60 CB LEU 9
20.189 66.483 15.190 1.00 20.04 6 ATOM 61 CG LEU 9 18.725 66.363
15.596 1.00 20.57 6 ATOM 62 CD1 LEU 9 17.980 67.624 15.214 1.00
19.57 6 ATOM 63 CD2 LEU 9 18.084 65.137 14.903 1.00 23.44 6 ATOM 64
C LEU 9 21.019 67.415 17.346 1.00 21.01 6 ATOM 65 O LEU 9 21.424
66.393 17.869 1.00 22.38 8 ATOM 66 N GLU 10 20.583 68.410 18.118
1.00 22.53 7 ATOM 67 CA GLU 10 20.480 68.285 19.567 1.00 21.02 6
ATOM 68 CB GLU 10 21.523 69.182 20.270 1.00 27.36 6 ATOM 69 CGA GLU
10 22.971 68.778 20.090 0.50 28.21 6 ATOM 70 CGB GLU 10 22.946
68.657 20.195 0.50 38.29 6 ATOM 71 CDA GLU 10 24.047 69.789 20.422
0.50 28.55 6 ATOM 72 CDB GLU 10 23.100 67.202 20.587 0.50 43.48 6
ATOM 73 OE1 GLU 10 25.131 69.365 20.907 0.50 26.56 8 ATOM 74 OE1
GLU 10 22.443 66.771 21.565 0.50 47.24 8 ATOM 75 OE2 GLU 10 23.888
71.008 20.186 0.50 22.10 8 ATOM 76 OE2 GLU 10 23.871 66.486 19.908
0.50 46.42 8 ATOM 77 C GLU 10 19.096 68.728 20.008 1.00 19.76 6
ATOM 78 O GLU 10 18.701 69.842 19.613 1.00 18.00 8 ATOM 79 N PRO 11
18.423 67.995 20.888 1.00 19.07 7 ATOM 80 CD PRO 11 17.058 68.340
21.390 1.00 18.71 6 ATOM 81 CA PRO 11 18.834 66.662 21.319 1.00
18.84 6 ATOM 82 CB PRO 11 17.807 66.272 22.365 1.00 17.38 6 ATOM 83
CG PRO 11 16.560 67.000 21.944 1.00 18.86 6 ATOM 84 C PRO 11 18.787
65.758 20.090 1.00 20.01 6 ATOM 85 O PRO 11 18.310 66.212 19.051
1.00 16.22 8 ATOM 86 N PRO 12 19.232 64.517 20.155 1.00 19.94 7
ATOM 87 CD PRO 12 19.915 63.948 21.361 1.00 21.08 6 ATOM 88 CA PRO
12 19.409 63.700 18.976 1.00 20.68 6 ATOM 89 CB PRO 12 20.455
62.656 19.397 1.00 19.82 6 ATOM 90 CG PRO 12 20.292 62.567 20.872
1.00 23.59 6 ATOM 91 C PRO 12 18.179 63.061 18.395 1.00 18.70 6
ATOM 92 O PRO 12 18.268 62.475 17.318 1.00 19.85 8 ATOM 93 N TRP 13
17.039 63.169 19.059 1.00 15.64 7 ATOM 94 CA TRP 13 15.815 62.568
18.561 1.00 17.91 6 ATOM 95 CB TRP 13 14.688 62.840 19.562 1.00
14.32 6 ATOM 96 CG TRP 13 15.124 62.749 21.006 1.00 16.77 6 ATOM 97
CD2 TRP 13 15.633 61.612 21.703 1.00 16.90 6 ATOM 98 CE2 TRP 13
15.899 62.005 23.032 1.00 16.87 6 ATOM 99 CE3 TRP 13 15.867 60.279
21.350 1.00 18.03 6 ATOM 100 CD1 TRP 13 15.106 63.769 21.916 1.00
18.97 6 ATOM 101 NE1 TRP 13 15.589 63.343 23.137 1.00 11.16 7 ATOM
102 CZ2 TRP 13 16.405 61.124 23.973 1.00 15.92 6 ATOM 103 CZ3 TRP
13 16.358 59.409 22.301 1.00 10.59 6 ATOM 104 CH2 TRP 13 16.645
59.825 23.611 1.00 17.87 6 ATOM 105 C TRP 13 15.421 63.033 17.163
1.00 19.47 6 ATOM 106 O TRP 13 15.283 64.238 16.908 1.00 17.22 8
ATOM 107 N ILE 14 15.101 62.078 16.275 1.00 16.57 7 ATOM 108 CA ILE
14 14.666 62.441 14.936 1.00 18.93 6 ATOM 109 CB ILE 14 15.185
61.523 13.816 1.00 16.07 6 ATOM 110 CG2 ILE 14 16.720 61.521 13.840
1.00 16.61 6 ATOM 111 CG1 ILE 14 14.582 60.119 13.972 1.00 21.35 6
ATOM 112 CD1 ILE 14 15.045 59.150 12.896 1.00 26.28 6 ATOM 113 C
ILE 14 13.144 62.549 14.825 1.00 20.48 6 ATOM 114 O ILE 14 12.652
63.048 13.817 1.00 19.41 8 ATOM 115 N ASN 15 12.403 62.087 15.836
1.00 19.46 7 ATOM 116 CA ASN 15 10.935 62.270 15.778 1.00 18.11 6
ATOM 117 CB ASN 15 10.161 60.962 15.731 1.00 13.53 6 ATOM 118 CG
ASN 15 10.591 59.946 16.762 1.00 19.11 6 ATOM 119 OD1 ASN 15 11.728
59.959 17.227 1.00 13.35 8 ATOM 120 ND2 ASN 15 9.688 59.033 17.142
1.00 10.11 7 ATOM 121 C ASN 15 10.632 63.124 17.005 1.00 17.54 6
ATOM 122 O ASN 15 11.016 62.735 18.111 1.00 15.32 8 ATOM 123 N VAL
16 10.122 64.331 16.805 1.00 16.86 7 ATOM 124 CA VAL 16 9.871
65.273 17.893 1.00 15.77 6 ATOM 125 CB VAL 16 10.761 66.534 17.748
1.00 16.54 6 ATOM 126 CG1 VAL 16 12.251 66.141 17.733 1.00 13.42 6
ATOM 127 CG2 VAL 16 10.490 67.345 16.491 1.00 18.04 6 ATOM 128 C
VAL 16 8.420 65.708 17.921 1.00 19.01 6 ATOM 129 O VAL 16 7.618
65.381 17.010 1.00 17.12 8 ATOM 130 N LEU 17 8.022 66.422 18.964
1.00 17.68 7 ATOM 131 CA LEU 17 6.664 66.962 19.068 1.00 15.11 6
ATOM 132 CB LEU 17 6.162 66.726 20.522 1.00 20.26 6 ATOM 133 CG LEU
17 5.873 65.251 20.823 1.00 23.07 6 ATOM 134 CD1 LEU 17 5.447
65.013 22.253 1.00 17.70 6 ATOM 135 CD2 LEU 17 4.832 64.714 19.855
1.00 26.74 6 ATOM 136 C LEU 17 6.563 68.439 18.732 1.00 16.37 6
ATOM 137 O LEU 17 7.518 69.187 18.961 1.00 18.24 8 ATOM 138 N GLN
18 5.424 68.931 18.227 1.00 18.55 7 ATOM 139 CA GLN 18 5.237 70.370
18.032 1.00 19.13 6 ATOM 140 CB GLN 18 3.790 70.721 17.696 1.00
31.65 6 ATOM 141 CG GLN 18 3.510 71.249 16.314 1.00 37.32 6 ATOM
142 CD GLN 18 2.120 70.902 15.800 1.00 36.92 6 ATOM 143 OE1 GLN 18
1.953 70.032 14.943 1.00 30.97 8 ATOM 144 NE2 GLN 18 1.135 71.618
16.333 1.00 31.73 7 ATOM 145 C GLN 18 5.561 71.077 19.348 1.00
19.43 6 ATOM 146 O GLN 18 5.194 70.568 20.413 1.00 18.10 8 ATOM 147
N GLU 19 6.317 72.164 19.232 1.00 19.68 7 ATOM 148 CA GLU 19 6.727
73.045 20.293 1.00 18.88 6 ATOM 149 CB GLU 19 5.597 73.341 21.293
1.00 27.39 6 ATOM 150 CG GLU 19 4.649 74.418 20.714 1.00 30.12 6
ATOM 151 CD GLU 19 3.558 74.699 21.720 1.00 41.87 6 ATOM 152 OE1
GLU 19 3.857 75.330 22.758 1.00 48.83 8 ATOM 153 OE2 GLU 19 2.421
74.272 21.464 1.00 46.61 8 ATOM 154 C GLU 19 8.004 72.622 20.998
1.00 21.46 6 ATOM 155 O GLU 19 8.496 73.405 21.815 1.00 26.39 8
ATOM 156 N ASP 20 8.606 71.506 20.619 1.00 19.91 7 ATOM 157 CA ASP
20 9.898 71.094 21.114 1.00 20.76 6 ATOM 158 CB ASP 20 10.285
69.649 20.726 1.00 13.47 6 ATOM 159 CG ASP 20 9.587 68.578 21.526
1.00 13.93 6 ATOM 160 OD1 ASP 20 8.873 68.805 22.534 1.00 17.57 8
ATOM 161 OD2 ASP 20 9.723 67.405 21.104 1.00 13.79 8 ATOM 162 C ASP
20 11.002 71.950 20.451 1.00 19.58 6 ATOM 163 O ASP 20 10.913
72.219 19.262 1.00 17.49 8 ATOM 164 N SER 21 12.071 72.198 21.174
1.00 17.22 7 ATOM 165 CA SER 21 13.233 72.929 20.659 1.00 17.62 6
ATOM 166 CBA SER 21 14.011 73.525 21.844 0.50 17.49 6 ATOM 167 CBB
SER 21 13.981 73.556 21.846 0.50 13.14 6 ATOM 168 OGA SER 21 14.900
74.516 21.355 0.50 22.95 8 ATOM 169 OGB SER 21 13.175 74.579 22.416
0.50 6.85 8 ATOM 170 C SER 21 14.181 72.038 19.873 1.00 18.61 6
ATOM 171 O SER 21 14.424 70.884 20.265 1.00 21.41 8 ATOM 172 N VAL
22 14.638 72.512 18.721 1.00 15.80 7 ATOM 173 CA VAL 22 15.585
71.733 17.910 1.00 17.93 6 ATOM 174 CB VAL 22 15.052 71.234 16.560
1.00 20.37 6 ATOM 175 CG1 VAL 22 16.093 70.401 15.804 1.00 17.77 6
ATOM 176 CG2 VAL 22 13.858 70.300 16.679 1.00 17.26 6 ATOM 177 C
VAL 22 16.822 72.609 17.665 1.00 19.20 6 ATOM 178 O VAL 22 16.633
73.769 17.291 1.00 18.52 8 ATOM 179 N THR 23 18.021 72.107 17.917
1.00 16.32 7 ATOM 180 CA THR 23 19.249 72.823 17.648 1.00 19.99 6
ATOM 181 CB THR 23 20.080 73.128 18.911 1.00 22.97 6 ATOM 182 OG1
THR 23 19.192 73.749 19.850 1.00 18.42 8 ATOM 183 CG2 THR 23 21.241
74.057 18.614 1.00 16.78 6 ATOM 184 C THR 23 20.098 72.016 16.658
1.00 24.68 6 ATOM 185 O THR 23 20.509 70.880 16.897 1.00 22.59 8
ATOM 186 N LEU 24 20.257 72.618 15.467 1.00 23.73 7 ATOM 187 CA LEU
24 21.081 72.051 14.423 1.00 23.11 6 ATOM 188 CB LEU 24 20.427
72.206 13.046 1.00 20.25 6 ATOM 189 CG LEU 24 19.053 71.480 12.959
1.00 23.95 6 ATOM 190 CD1 LEU 24 18.324 71.856 11.681 1.00 20.78 6
ATOM 191 CD2 LEU 24 19.251 69.985 13.049 1.00 22.74 6 ATOM 192 C
LEU 24 22.444 72.763 14.450 1.00 25.87 6 ATOM 193 O LEU 24 22.470
74.008 14.537 1.00 24.57 8 ATOM 194 N THR 25 23.520 71.980 14.367
1.00 20.22 7 ATOM 195 CA THR 25 24.847 72.600 14.336 1.00 23.21 6
ATOM 196 CB THR 25 25.656 72.265 15.597 1.00 27.69 6 ATOM 197 OG1
THR 25 24.945 72.730 16.755 1.00 26.30 8 ATOM 198 CG2 THR 25 27.041
72.925 15.590 1.00 28.49 6 ATOM 199 C THR 25 25.604 72.166 13.075
1.00 22.31 6 ATOM 200 O THR 25 25.706 70.951 12.819 1.00 23.86 8
ATOM 201 N CYS 26 26.092 73.134 12.307 1.00 18.68 7 ATOM 202 CA CYS
26 26.832 72.888 11.075 1.00 23.20 6 ATOM 203 C CYS 26 28.345
72.910 11.346 1.00 23.06 6 ATOM 204 O CYS 26 28.957 73.980 11.556
1.00 23.76 8 ATOM 205 CB CYS 26 26.509 73.881 9.958 1.00 17.92 6
ATOM 206 SG CYS 26 27.138 73.358 8.311 1.00 22.25 16 ATOM 207 N GLN
27 28.929 71.729 11.355 1.00 19.35 7 ATOM 208 CA GLN 27 30.332
71.521 11.658 1.00 23.30 6 ATOM 209 CB GLN 27 30.543 70.209 12.464
1.00 29.78 6 ATOM 210 CG GLN 27 29.623 70.044 13.672 1.00 31.50 6
ATOM 211 CD GLN 27 29.927 68.828 14.518 1.00 33.01 6 ATOM 212 OE1
GLN 27 30.322 67.774 14.032 1.00 38.67 8 ATOM 213 NE2 GLN 27 29.792
68.895 15.834 1.00 36.36 7 ATOM 214 C GLN 27 31.169 71.417 10.377
1.00 26.33 6 ATOM 215 O GLN 27 30.764 70.856 9.347 1.00 23.15 8
ATOM 216 N GLY 28 32.363 72.019 10.438 1.00 27.69 7 ATOM 217 CA GLY
28 33.289 72.019 9.313 1.00 28.02 6 ATOM 218 C GLY 28 34.022 73.360
9.215 1.00 29.41 6 ATOM 219 O GLY 28 33.639 74.335 9.862 1.00 28.46
8 ATOM 220 N ALA 29 35.062 73.421 8.389 1.00 27.48 7 ATOM 221 CA
ALA 29 35.824 74.640 8.210 1.00 27.39 6 ATOM 222 CB ALA 29 36.979
74.353 7.239 1.00 25.91 6 ATOM 223 C ALA 29 34.959 75.730 7.574
1.00 28.27 6 ATOM 224 O ALA 29 34.315 75.415 6.561 1.00 26.07 8
ATOM 225 N ARG 30 35.060 76.951 8.064 1.00 23.97 7 ATOM 226 CA ARG
30 34.303 78.055 7.490 1.00 27.17 6 ATOM 227 CB ARG 30 33.571
78.823 8.601 1.00 30.34 6 ATOM 228 CG ARG 30 32.574 78.090 9.460
1.00 34.05 6 ATOM 229 CD ARG 30 32.365 78.880 10.761 1.00 33.86 6
ATOM 230 NE ARG 30 32.407 77.902 11.836 1.00 38.60 7 ATOM 231 CZ
ARG 30 32.487 78.082 13.126 1.00 38.08 6 ATOM 232 NH1 ARG 30 32.567
79.298 13.635 1.00 36.51 7 ATOM 233 NH2 ARG 30 32.467 76.990 13.879
1.00 46.13 7 ATOM 234 C ARG 30 35.194 79.148 6.880 1.00 26.70 6
ATOM 235 O ARG 30 36.399 79.142 7.075 1.00 29.22 8 ATOM 236 N SER
31 34.573 80.129 6.246 1.00 26.85 7 ATOM 237 CA SER 31 35.315
81.284 5.738 1.00 26.56 6 ATOM 238 CB SER 31 34.682 81.846 4.476
1.00 25.03 6 ATOM 239 OG SER 31 34.562 80.875 3.477 1.00 27.59 8
ATOM 240 C SER 31 35.273 82.321 6.861 1.00 26.58 6 ATOM 241 O SER
31 34.396 82.246 7.739 1.00 23.91 8 ATOM 242 N PRO 32 36.163 83.308
6.839 1.00 23.48 7 ATOM 243 CD PRO 32 37.224 83.483 5.842 1.00
22.70 6 ATOM 244 CA PRO 32 36.176 84.350 7.861 1.00 24.75 6 ATOM
245 CB PRO 32 37.621 84.830 7.805 1.00 24.34 6 ATOM 246 CG PRO 32
38.095 84.571 6.414 1.00 23.77 6 ATOM 247 C PRO 32 35.172 85.449
7.549 1.00 29.23 6 ATOM 248 O PRO 32 35.472 86.609 7.223 1.00 28.28
8 ATOM 249 N GLU 33 33.913 85.121 7.709 1.00 29.77 7 ATOM 250 CA
GLU 33 32.725 85.896 7.417 1.00 33.37 6 ATOM 251 CBA GLU 33 32.177
85.426 6.073 0.50 35.18 6 ATOM 252 CBB GLU 33 32.123 85.457 6.084
0.50 31.98 6 ATOM 253 CGA GLU 33 30.795 84.829 5.952 0.50 39.40 6
ATOM 254 CGB GLU 33 31.776 83.990 5.954 0.50 34.05 6 ATOM 255 CDA
GLU 33 30.394 84.525 4.521 0.50 46.48 6 ATOM 256 CDB GLU 33 31.601
83.533 4.517 0.50 34.67 6 ATOM 257 OE1 GLU 33 29.268 84.856 4.076
0.50 49.23 8 ATOM 258 OE1 GLU 33 32.194 84.168 3.619 0.50 32.81 8
ATOM 259 OE2 GLU 33 31.232 83.952 3.788 0.50 47.50 8 ATOM 260 OE2
GLU 33 30.877 82.542 4.275 0.50 24.64 8 ATOM 261 C GLU 33 31.683
85.689 8.519 1.00 32.61 6 ATOM 262 O GLU 33 31.612 84.600 9.085
1.00 28.72 8 ATOM 263 N SER 34 30.844 86.682 8.743 1.00 32.15 7
ATOM 264 CA SER 34 29.804 86.591 9.764 1.00 32.72 6 ATOM 265 CB SER
34 29.277 88.013 10.037 1.00 34.26 6 ATOM 266 OG SER 34 28.320
87.931 11.093 1.00 45.88 8 ATOM 267 C SER 34 28.668 85.674 9.332
1.00 30.93 6 ATOM 268 O SER 34 28.156 84.883 10.124 1.00 28.87 8
ATOM 269 N ASP 35 28.222 85.773 8.082 1.00 28.02 7 ATOM 270 CA ASP
35 27.167 84.858 7.599 1.00 28.62 6 ATOM 271 CB ASP 35 26.292
85.538 6.585 1.00 29.65 6 ATOM 272 CG ASP 35 25.357 86.639 7.057
1.00 37.43 6 ATOM 273 OD1 ASP 35 25.027 86.769 8.258 1.00 33.53 8
ATOM 274 OD2 ASP 35 24.902 87.396 6.154 1.00 36.01 8 ATOM 275 C ASP
35 27.882 83.643 6.973 1.00 27.08 6 ATOM 276 O ASP 35 27.997 83.566
5.756 1.00 28.07 8 ATOM 277 N SER 36 28.461 82.748 7.774 1.00 25.55
7 ATOM 278 CA SER 36 29.282 81.680 7.225 1.00 27.45 6 ATOM 279 CB
SER 36 30.440 81.431 8.213 1.00 34.87 6 ATOM 280 OG SER 36 29.973
80.802 9.405 1.00 39.51 8 ATOM 281 C SER 36 28.558 80.382 6.890
1.00 27.14 6 ATOM 282 O SER 36 29.143 79.421 6.363 1.00 25.67 8
ATOM 283 N ILE 37 27.293 80.223 7.231 1.00 24.64 7 ATOM 284 CA ILE
37 26.580 78.973 6.977 1.00 24.33 6 ATOM 285 CB ILE 37 26.164
78.307 8.309 1.00 30.71 6 ATOM 286 CG2 ILE 37 25.561 76.931 8.032
1.00 26.94 6 ATOM 287 CG1 ILE 37 27.333 78.221 9.308 1.00 21.66 6
ATOM 288 CD1 ILE 37 28.443 77.278 8.867 1.00 27.66 6 ATOM 289 C ILE
37 25.336 79.159 6.128 1.00 24.08 6 ATOM 290 O ILE 37 24.515 80.033
6.390 1.00 23.50 8 ATOM 291 N GLN 38 25.122 78.314 5.127 1.00 24.52
7 ATOM 292 CA GLN 38 23.862 78.296 4.399 1.00 23.13 6 ATOM 293 CB
GLN 38 24.016 78.068 2.905 1.00 29.28 6 ATOM 294 CG GLN 38 24.458
79.296 2.123 1.00 29.86 6 ATOM 295 CD GLN 38 24.692 78.965 0.661
1.00 33.48 6 ATOM 296 OE1 GLN 38 25.540 78.122 0.323 1.00 28.34 8
ATOM 297 NE2 GLN 38 23.922 79.668 -0.177 1.00 38.54 7 ATOM 298 C
GLN 38 23.048 77.128 4.985 1.00 23.81 6 ATOM 299 O GLN 38 23.598
76.022 5.087 1.00 22.62 8 ATOM 300 N TRP 39 21.807
77.386 5.371 1.00 21.43 7 ATOM 301 CA TRP 39 20.987 76.304 5.905
1.00 21.73 6 ATOM 302 CB TRP 39 20.345 76.633 7.257 1.00 21.01 6
ATOM 303 CG TRP 39 21.264 76.633 8.430 1.00 17.58 6 ATOM 304 CD2
TRP 39 21.721 75.523 9.212 1.00 17.00 6 ATOM 305 CE2 TRP 39 22.569
76.033 10.220 1.00 16.71 6 ATOM 306 CE3 TRP 39 21.495 74.147 9.158
1.00 21.47 6 ATOM 307 CD1 TRP 39 21.844 77.750 8.974 1.00 19.92 6
ATOM 308 NE1 TRP 39 22.626 77.400 10.061 1.00 22.18 7 ATOM 309 CZ2
TRP 39 23.218 75.220 11.152 1.00 18.29 6 ATOM 310 CZ3 TRP 39 22.109
73.329 10.091 1.00 21.62 6 ATOM 311 CH2 TRP 39 22.960 73.874 11.064
1.00 20.15 6 ATOM 312 C TRP 39 19.890 75.993 4.898 1.00 22.76 6
ATOM 313 O TRP 39 19.407 76.925 4.238 1.00 23.42 8 ATOM 314 N PHE
40 19.533 74.701 4.758 1.00 22.91 7 ATOM 315 CA PHE 40 18.512
74.389 3.754 1.00 26.86 6 ATOM 316 CB PHE 40 19.121 73.722 2.513
1.00 24.16 6 ATOM 317 CG PHE 40 20.225 74.429 1.788 1.00 23.96 6
ATOM 318 CD1 PHE 40 21.551 74.280 2.189 1.00 23.61 6 ATOM 319 CD2
PHE 40 19.945 75.244 0.696 1.00 22.47 6 ATOM 320 CE1 PHE 40 22.564
74.919 1.504 1.00 20.83 6 ATOM 321 CE2 PHE 40 20.967 75.880 0.020
1.00 21.69 6 ATOM 322 CZ PHE 40 22.267 75.740 0.432 1.00 21.86 6
ATOM 323 C PHE 40 17.466 73.435 4.349 1.00 23.51 6 ATOM 324 O PHE
40 17.838 72.588 5.151 1.00 21.94 8 ATOM 325 N HIS 41 16.232 73.575
3.905 1.00 21.59 7 ATOM 326 CA HIS 41 15.107 72.771 4.366 1.00
24.07 6 ATOM 327 CB HIS 41 14.032 73.572 5.099 1.00 18.72 6 ATOM
328 CG HIS 41 12.864 72.727 5.548 1.00 23.41 6 ATOM 329 CD2 HIS 41
12.794 71.415 5.899 1.00 21.85 6 ATOM 330 ND1 HIS 41 11.588 73.218
5.709 1.00 21.97 7 ATOM 331 CE1 HIS 41 10.789 72.259 6.135 1.00
22.79 6 ATOM 332 NE2 HIS 41 11.504 71.161 6.268 1.00 21.87 7 ATOM
333 C HIS 41 14.455 72.163 3.115 1.00 21.83 6 ATOM 334 O HIS 41
13.972 72.919 2.282 1.00 21.37 8 ATOM 335 N ASN 42 14.576 70.847
2.959 1.00 22.08 7 ATOM 336 CA ASN 42 14.077 70.196 1.726 1.00
20.46 6 ATOM 337 CB ASN 42 12.562 70.322 1.722 1.00 18.21 6 ATOM
338 CG ASN 42 11.925 69.397 2.761 1.00 22.74 6 ATOM 339 OD1 ASN 42
12.473 68.343 3.087 1.00 24.40 8 ATOM 340 ND2 ASN 42 10.804 69.804
3.341 1.00 18.43 7 ATOM 341 C ASN 42 14.733 70.811 0.488 1.00 21.32
6 ATOM 342 O ASN 42 14.085 71.047 -0.533 1.00 20.13 8 ATOM 343 N
GLY 43 16.002 71.220 0.568 1.00 20.53 7 ATOM 344 CA GLY 43 16.767
71.861 -0.480 1.00 20.83 6 ATOM 345 C GLY 43 16.586 73.360 -0.661
1.00 24.51 6 ATOM 346 O GLY 43 17.209 73.987 -1.550 1.00 25.30 8
ATOM 347 N ASN 44 15.633 73.970 0.051 1.00 21.27 7 ATOM 348 CA ASN
44 15.391 75.393 -0.112 1.00 20.46 6 ATOM 349 CB ASN 44 13.903
75.734 0.000 1.00 23.82 6 ATOM 350 CG ASN 44 13.049 74.834 -0.891
1.00 22.26 6 ATOM 351 OD1 ASN 44 12.148 74.144 -0.409 1.00 25.47 8
ATOM 352 ND2 ASN 44 13.382 74.787 -2.171 1.00 21.59 7 ATOM 353 C
ASN 44 16.208 76.143 0.937 1.00 19.78 6 ATOM 354 O ASN 44 16.180
75.778 2.107 1.00 22.07 8 ATOM 355 N LEU 45 16.907 77.188 0.523
1.00 22.22 7 ATOM 356 CA LEU 45 17.730 77.962 1.459 1.00 21.67 6
ATOM 357 CB LEU 45 18.391 79.141 0.715 1.00 28.15 6 ATOM 358 CG LEU
45 19.159 80.171 1.538 1.00 29.14 6 ATOM 359 CD1 LEU 45 20.479
79.571 2.002 1.00 25.07 6 ATOM 360 CD2 LEU 45 19.452 81.466 0.775
1.00 28.51 6 ATOM 361 C LEU 45 16.825 78.559 2.525 1.00 22.27 6
ATOM 362 O LEU 45 15.748 78.997 2.118 1.00 20.13 8 ATOM 363 N ILE
46 17.263 78.604 3.766 1.00 20.11 7 ATOM 364 CA ILE 46 16.539
79.322 4.835 1.00 24.64 6 ATOM 365 CB ILE 46 16.657 78.508 6.132
1.00 22.24 6 ATOM 366 CG2 ILE 46 16.007 79.134 7.358 1.00 21.33 6
ATOM 367 CG1 ILE 46 16.111 77.072 5.945 1.00 20.74 6 ATOM 368 CD1
ILE 46 16.664 76.147 7.024 1.00 20.48 6 ATOM 369 C ILE 46 17.351
80.625 5.006 1.00 25.53 6 ATOM 370 O ILE 46 18.419 80.600 5.624
1.00 22.91 8 ATOM 371 N PRO 47 16.937 81.747 4.444 1.00 30.56 7
ATOM 372 CD PRO 47 15.704 81.884 3.620 1.00 32.61 6 ATOM 373 CA PRO
47 17.731 82.968 4.434 1.00 30.93 6 ATOM 374 CB PRO 47 17.030
83.836 3.363 1.00 31.28 6 ATOM 375 CG PRO 47 15.610 83.400 3.441
1.00 32.54 6 ATOM 376 C PRO 47 17.888 83.762 5.706 1.00 28.32 6
ATOM 377 O PRO 47 18.733 84.670 5.747 1.00 29.24 8 ATOM 378 N THR
48 17.092 83.513 6.730 1.00 26.79 7 ATOM 379 CA THR 48 17.135
84.298 7.971 1.00 26.97 6 ATOM 380 CB THR 48 15.698 84.323 8.532
1.00 31.78 6 ATOM 381 OG1 THR 48 15.241 82.958 8.520 1.00 31.45 8
ATOM 382 CG2 THR 48 14.798 85.150 7.605 1.00 27.40 6 ATOM 383 C THR
48 18.075 83.757 9.021 1.00 26.31 6 ATOM 384 O THR 48 18.206 84.334
10.113 1.00 28.00 8 ATOM 385 N HIS 49 18.698 82.602 8.772 1.00
24.44 7 ATOM 386 CA HIS 49 19.612 81.942 9.707 1.00 24.19 6 ATOM
387 CB HIS 49 18.953 80.610 10.174 1.00 25.11 6 ATOM 388 CG HIS 49
17.722 80.939 10.961 1.00 22.20 6 ATOM 389 CD2 HIS 49 16.430 81.109
10.624 1.00 27.86 6 ATOM 390 ND1 HIS 49 17.809 81.225 12.306 1.00
29.80 7 ATOM 391 CE1 HIS 49 16.595 81.526 12.762 1.00 28.91 6 ATOM
392 NE2 HIS 49 15.748 81.474 11.761 1.00 25.35 7 ATOM 393 C HIS 49
20.923 81.588 9.041 1.00 23.08 6 ATOM 394 O HIS 49 20.942 80.805
8.075 1.00 20.57 8 ATOM 395 N THR 50 22.038 82.162 9.497 1.00 25.11
7 ATOM 396 CA THR 50 23.321 81.974 8.807 1.00 22.98 6 ATOM 397 CB
THR 50 23.732 83.314 8.137 1.00 23.01 6 ATOM 398 OG1 THR 50 23.843
84.252 9.231 1.00 18.66 8 ATOM 399 CG2 THR 50 22.757 83.817 7.101
1.00 19.07 6 ATOM 400 C THR 50 24.460 81.645 9.766 1.00 24.61 6
ATOM 401 O THR 50 25.640 81.772 9.393 1.00 26.17 8 ATOM 402 N GLN
51 24.126 81.274 10.985 1.00 24.52 7 ATOM 403 CA GLN 51 25.132
80.979 11.995 1.00 27.31 6 ATOM 404 CB GLN 51 24.708 81.505 13.378
1.00 28.63 6 ATOM 405 CG GLN 51 24.438 83.014 13.378 1.00 32.81 6
ATOM 406 CD GLN 51 25.677 83.810 12.995 1.00 38.53 6 ATOM 407 OE1
GLN 51 26.606 83.952 13.802 1.00 37.60 8 ATOM 408 NE2 GLN 51 25.724
84.331 11.765 1.00 32.79 7 ATOM 409 C GLN 51 25.411 79.487 12.101
1.00 26.69 6 ATOM 410 O GLN 51 24.626 78.636 11.689 1.00 26.27 8
ATOM 411 N PRO 52 26.510 79.138 12.769 1.00 25.16 7 ATOM 412 CD PRO
52 27.553 80.091 13.270 1.00 24.54 6 ATOM 413 CA PRO 52 26.917
77.763 12.974 1.00 25.24 6 ATOM 414 CB PRO 52 28.264 77.888 13.708
1.00 26.09 6 ATOM 415 CG PRO 52 28.804 79.217 13.257 1.00 23.35 6
ATOM 416 C PRO 52 25.900 76.915 13.722 1.00 25.71 6 ATOM 417 O PRO
52 25.877 75.687 13.542 1.00 21.61 8 ATOM 418 N SER 53 25.044
77.497 14.556 1.00 24.05 7 ATOM 419 CA SER 53 23.991 76.773 15.239
1.00 25.63 6 ATOM 420 CB SER 53 24.105 76.711 16.758 1.00 31.86 6
ATOM 421 OG SER 53 24.778 75.495 17.094 1.00 42.46 8 ATOM 422 C SER
53 22.681 77.460 14.854 1.00 24.85 6 ATOM 423 O SER 53 22.681
78.673 14.691 1.00 23.68 8 ATOM 424 N TYR 54 21.658 76.689 14.614
1.00 24.52 7 ATOM 425 CA TYR 54 20.333 77.167 14.212 1.00 26.29 6
ATOM 426 CB TYR 54 20.050 76.886 12.729 1.00 26.92 6 ATOM 427 CG
TYR 54 18.612 76.998 12.274 1.00 30.15 6 ATOM 428 CD1 TYR 54 17.719
77.905 12.825 1.00 29.18 6 ATOM 429 CE1 TYR 54 16.407 78.006 12.409
1.00 31.26 6 ATOM 430 CD2 TYR 54 18.104 76.166 11.280 1.00 31.67 6
ATOM 431 CE2 TYR 54 16.796 76.217 10.855 1.00 31.66 6 ATOM 432 CZ
TYR 54 15.950 77.151 11.429 1.00 33.63 6 ATOM 433 OH TYR 54 14.624
77.219 11.038 1.00 34.53 8 ATOM 434 C TYR 54 19.378 76.450 15.167
1.00 24.84 6 ATOM 435 O TYR 54 19.300 75.210 15.129 1.00 22.53 8
ATOM 436 N ARG 55 18.773 77.181 16.070 1.00 21.66 7 ATOM 437 CA ARG
55 17.864 76.650 17.070 1.00 23.60 6 ATOM 438 CB ARG 55 18.242
77.157 18.480 1.00 25.95 6 ATOM 439 CG ARG 55 17.478 76.340 19.551
1.00 23.98 6 ATOM 440 CD ARG 55 17.651 76.982 20.918 1.00 35.38 6
ATOM 441 NE ARG 55 16.821 76.365 21.956 1.00 27.47 7 ATOM 442 CZ
ARG 55 17.278 75.530 22.879 1.00 33.10 6 ATOM 443 NH1 ARG 55 18.570
75.209 22.904 1.00 30.00 7 ATOM 444 NH2 ARG 55 16.418 75.049 23.778
1.00 32.66 7 ATOM 445 C ARG 55 16.434 77.103 16.802 1.00 27.49 6
ATOM 446 O ARG 55 16.275 78.312 16.569 1.00 22.62 8 ATOM 447 N PHE
56 15.455 76.174 16.781 1.00 23.78 7 ATOM 448 CA PHE 56 14.092
76.636 16.510 1.00 21.92 6 ATOM 449 CB PHE 56 13.716 76.495 15.036
1.00 25.99 6 ATOM 450 CG PHE 56 13.819 75.131 14.386 1.00 20.84 6
ATOM 451 CD1 PHE 56 15.019 74.653 13.897 1.00 21.33 6 ATOM 452 CD2
PHE 56 12.705 74.319 14.264 1.00 20.31 6 ATOM 453 CE1 PHE 56 15.103
73.415 13.283 1.00 21.52 6 ATOM 454 CE2 PHE 56 12.768 73.077 13.680
1.00 18.36 6 ATOM 455 CZ PHE 56 13.973 72.616 13.159 1.00 18.38 6
ATOM 456 C PHE 56 13.095 75.862 17.372 1.00 23.93 6 ATOM 457 O PHE
56 13.454 74.833 17.921 1.00 22.42 8 ATOM 458 N LYS 57 11.865
76.340 17.423 1.00 22.46 7 ATOM 459 CA LYS 57 10.735 75.659 18.054
1.00 24.34 6 ATOM 460 CBA LYS 57 9.892 76.620 18.881 0.50 28.51 6
ATOM 461 CBB LYS 57 9.822 76.727 18.669 0.50 22.87 6 ATOM 462 CGA
LYS 57 10.656 77.298 20.010 0.50 33.64 6 ATOM 463 CGB LYS 57 8.769
76.208 19.632 0.50 24.29 6 ATOM 464 CDA LYS 57 11.436 76.342 20.892
0.50 40.75 6 ATOM 465 CDB LYS 57 8.631 77.186 20.798 0.50 26.90 6
ATOM 466 CEA LYS 57 12.612 76.990 21.603 0.50 43.07 6 ATOM 467 CEB
LYS 57 9.138 76.604 22.092 0.50 29.79 6 ATOM 468 NZA LYS 57 12.703
76.630 23.044 0.50 51.71 7 ATOM 469 NZB LYS 57 8.050 76.265 23.060
0.50 36.22 7 ATOM 470 C LYS 57 9.950 74.923 16.969 1.00 21.30 6
ATOM 471 O LYS 57 9.436 75.551 16.052 1.00 19.46 8 ATOM 472 N ALA
58 9.928 73.588 16.945 1.00 18.23 7 ATOM 473 CA ALA 58 9.341 72.864
15.821 1.00 15.74 6 ATOM 474 CB ALA 58 9.612 71.361 16.094 1.00
9.09 6 ATOM 475 C ALA 58 7.841 73.034 15.614 1.00 20.26 6 ATOM 476
O ALA 58 7.067 73.064 16.574 1.00 18.04 8 ATOM 477 N ASN 59 7.392
73.126 14.367 1.00 18.31 7 ATOM 478 CA ASN 59 5.986 73.071 14.019
1.00 23.04 6 ATOM 479 CB ASN 59 5.222 74.301 13.612 1.00 32.39 6
ATOM 480 CG ASN 59 5.880 75.643 13.665 1.00 38.26 6 ATOM 481 OD1
ASN 59 5.855 76.279 14.716 1.00 42.50 8 ATOM 482 ND2 ASN 59 6.426
76.066 12.529 1.00 43.39 7 ATOM 483 C ASN 59 5.825 72.052 12.867
1.00 24.07 6 ATOM 484 O ASN 59 6.794 71.476 12.365 1.00 21.25 8
ATOM 485 N ASN 60 4.582 71.833 12.484 1.00 24.40 7 ATOM 486 CA ASN
60 4.192 70.823 11.519 1.00 31.47 6 ATOM 487 CB ASN 60 2.680 70.893
11.234 1.00 31.46 6 ATOM 488 CGA ASN 60 2.272 69.776 10.274 0.50
31.26 6 ATOM 489 CGB ASN 60 2.221 72.272 10.814 0.50 35.72 6 ATOM
490 OD1 ASN 60 2.337 68.582 10.597 0.50 22.52 8 ATOM 491 OD1 ASN 60
2.985 73.240 10.768 0.50 33.04 8 ATOM 492 ND2 ASN 60 1.863 70.175
9.070 0.50 26.04 7 ATOM 493 ND2 ASN 60 0.932 72.391 10.483 0.50
39.47 7 ATOM 494 C ASN 60 5.006 70.943 10.234 1.00 29.05 6 ATOM 495
O ASN 60 5.645 69.986 9.780 1.00 32.27 8 ATOM 496 N ASN 61 5.098
72.153 9.710 1.00 30.20 7 ATOM 497 CAA ASN 61 5.863 72.487 8.529
0.50 28.68 6 ATOM 498 CAB ASN 61 5.857 72.367 8.477 0.50 29.13 6
ATOM 499 CBA ASN 61 5.564 73.955 8.150 0.50 26.19 6 ATOM 500 CBB
ASN 61 5.403 73.671 7.806 0.50 30.25 6 ATOM 501 CGA ASN 61 4.101
74.127 7.792 0.50 27.01 6 ATOM 502 CGB ASN 61 5.608 74.882 8.678
0.50 32.36 6 ATOM 503 OD1 ASN 61 3.502 75.125 8.184 0.50 28.58 8
ATOM 504 OD1 ASN 61 6.383 74.820 9.637 0.50 33.38 8 ATOM 505 ND2
ASN 61 3.526 73.172 7.071 0.50 34.39 7 ATOM 506 ND2 ASN 61 4.927
75.991 8.384 0.50 33.52 7 ATOM 507 C ASN 61 7.371 72.336 8.628 1.00
25.33 6 ATOM 508 O ASN 61 8.030 72.535 7.617 1.00 21.46 8 ATOM 509
N ASP 62 7.932 71.978 9.767 1.00 24.89 7 ATOM 510 CA ASP 62 9.373
71.842 9.941 1.00 21.37 6 ATOM 511 CB ASP 62 9.749 72.284 11.372
1.00 16.89 6 ATOM 512 CG ASP 62 9.620 73.782 11.538 1.00 26.20 6
ATOM 513 OD1 ASP 62 9.824 74.549 10.570 1.00 20.81 8 ATOM 514 OD2
ASP 62 9.276 74.273 12.611 1.00 17.90 8 ATOM 515 C ASP 62 9.887
70.439 9.645 1.00 18.69 6 ATOM 516 O ASP 62 11.104 70.209 9.654
1.00 20.50 8 ATOM 517 N SER 63 9.011 69.477 9.394 1.00 19.81 7 ATOM
518 CA SER 63 9.434 68.132 9.015 1.00 19.84 6 ATOM 519 CB SER 63
8.268 67.164 8.811 1.00 22.04 6 ATOM 520 OG SER 63 7.506 67.018
10.009 1.00 20.02 8 ATOM 521 C SER 63 10.196 68.204 7.682 1.00
23.89 6 ATOM 522 O SER 63 10.015 69.160 6.911 1.00 17.92 8 ATOM 523
N GLY 64 11.056 67.195 7.467 1.00 19.50 7 ATOM 524 CA GLY 64 11.769
67.191 6.190 1.00 22.23 6 ATOM 525 C GLY 64 13.272 66.965 6.340
1.00 19.81 6 ATOM 526 O GLY 64 13.744 66.564 7.399 1.00 18.93 8
ATOM 527 N GLU 65 13.980 67.226 5.238 1.00 17.01 7 ATOM 528 CA GLU
65 15.428 67.013 5.269 1.00 21.39 6 ATOM 529 CBA GLU 65 15.934
66.562 3.901 0.50 13.64 6 ATOM 530 CBB GLU 65 15.933 66.446 3.947
0.50 23.81 6 ATOM 531 CGA GLU 65 16.507 65.158 3.813 0.50 15.71 6
ATOM 532 CGB GLU 65 15.409 65.059 3.602 0.50 32.15 6 ATOM 533 CDA
GLU 65 16.656 64.679 2.381 0.50 22.33 6 ATOM 534 CDB GLU 65 15.898
63.965 4.520 0.50 40.56 6 ATOM 535 OE1 GLU 65 17.428 65.263 1.586
0.50 22.70 8 ATOM 536 OE1 GLU 65 16.578 64.271 5.525 0.50 41.83 8
ATOM 537 OE2 GLU 65 15.991 63.686 2.014 0.50 31.04 8 ATOM 538 OE2
GLU 65 15.624 62.758 4.278 0.50 46.02 8 ATOM 539 C GLU 65 16.155
68.324 5.593 1.00 21.56 6 ATOM 540 O GLU 65 15.756 69.325 5.007
1.00 21.41 8 ATOM 541 N TYR 66 17.172 68.268 6.458 1.00 21.38 7
ATOM 542 CA TYR 66 17.966 69.483 6.691 1.00 17.91 6 ATOM 543 CB TYR
66 17.954 69.984 8.129 1.00 17.39 6 ATOM 544 CG TYR 66 16.620
70.563 8.534 1.00 18.08 6 ATOM 545 CD1 TYR 66 15.605 69.686 8.957
1.00 18.56 6 ATOM 546 CE1 TYR 66 14.369 70.147 9.323 1.00 16.48 6
ATOM 547 CD2 TYR 66 16.348 71.921 8.485 1.00 18.23 6 ATOM 548 CE2
TYR 66 15.102 72.382 8.867 1.00 18.37 6 ATOM 549 CZ TYR 66 14.124
71.516 9.279 1.00 18.98 6 ATOM 550 OH TYR 66 12.872 71.939 9.624
1.00 14.14 8 ATOM 551 C TYR 66 19.379 69.231 6.212 1.00 13.96 6
ATOM 552 O TYR 66 19.923 68.135 6.353 1.00 18.14 8 ATOM 553 N THR
67 20.010 70.228 5.568 1.00 17.95 7 ATOM 554 CA THR 67 21.374
70.138 5.117 1.00 18.06 6 ATOM 555 CB THR 67 21.514 69.844 3.599
1.00 22.52 6 ATOM 556 OG1 THR 67 20.669 70.737 2.835 1.00 16.85 8
ATOM 557 CG2 THR 67 21.215 68.371 3.309 1.00 17.46 6 ATOM 558 C THR
67 22.044 71.508 5.384 1.00 18.76 6 ATOM 559 O THR 67 21.354 72.515
5.567 1.00 17.47 8 ATOM 560 N CYS 68 23.354 71.540 5.389 1.00 19.74
7 ATOM 561 CA CYS 68 24.099 72.792 5.597 1.00 23.50 6 ATOM 562 C
CYS 68 25.382 72.759 4.758 1.00 23.12 6 ATOM 563 O CYS 68 25.791
71.712 4.279 1.00 25.07 8 ATOM 564 CB CYS 68 24.434 73.082 7.055
1.00 18.70 6 ATOM 565 SG CYS 68 25.675 71.985 7.798 1.00 23.45 16
ATOM 566 N GLN 69 25.975 73.920 4.534 1.00 24.47 7 ATOM 567 CA GLN
69 27.174 74.121 3.770 1.00 24.99 6 ATOM 568 CB GLN 69 26.909
74.344 2.264 1.00 27.22 6 ATOM 569 CG GLN 69 28.155 74.057 1.419
1.00 25.14 6 ATOM 570 CD GLN 69 27.857 74.022 -0.065 1.00 32.43 6
ATOM 571 OE1 GLN 69 26.710 74.166 -0.487 1.00 31.34 8 ATOM 572 NE2
GLN 69 28.896 73.814 -0.874 1.00 27.89 7 ATOM 573 C GLN 69 27.901
75.383 4.266 1.00 27.60 6 ATOM 574 O GLN 69 27.289 76.352 4.734
1.00 25.37 8 ATOM 575 N THR 70 29.206 75.318 4.115 1.00 28.73 7
ATOM 576 CA THR 70 30.059 76.465 4.439 1.00 32.10 6 ATOM 577 CB THR
70 31.125 76.153 5.491 1.00 33.36 6 ATOM 578 OG1 THR 70 30.619
75.311 6.553 1.00 45.26 8 ATOM 579 CG2 THR 70 31.453 77.444 6.210
1.00 50.20 6 ATOM 580 C THR 70 30.737 76.890 3.138 1.00 32.77 6
ATOM 581 O THR 70 30.680 76.170 2.130 1.00 30.75 8 ATOM 582 N GLY
71 31.472 78.007 3.175 1.00 31.83 7 ATOM 583 CA GLY 71 32.224
78.469 2.033 1.00 27.97 6 ATOM 584 C GLY 71 33.376 77.544 1.690
1.00 29.94 6 ATOM 585 O GLY 71 33.938 77.668 0.596 1.00 32.37 8
ATOM 586 N GLN 72 33.842 76.707 2.594 1.00 24.86 7 ATOM 587 CA GLN
72 34.920 75.779 2.457 1.00 27.14 6 ATOM 588 CB GLN 72 35.868
75.974 3.667 1.00 27.31 6 ATOM 589 CG GLN 72 36.291 77.451 3.825
1.00 30.51 6 ATOM 590 CD GLN 72 36.961 77.995 2.567 1.00 30.53 6
ATOM 591 OE1 GLN 72 37.981 77.441 2.161 1.00 39.95 8 ATOM 592 NE2
GLN 72 36.402 79.014 1.944 1.00 31.16 7 ATOM 593 C GLN 72 34.530
74.305 2.441 1.00 29.60 6 ATOM 594 O GLN 72 35.419 73.442 2.578
1.00 30.82 8 ATOM 595 N THR 73 33.248 73.954 2.380 1.00 25.83 7
ATOM 596 CA THR 73 32.861 72.549 2.426 1.00 26.62 6 ATOM 597 CB THR
73 32.278 72.135 3.792 1.00 26.64 6 ATOM 598 OG1 THR 73 31.226
73.051 4.138 1.00 27.54 8 ATOM 599 CG2 THR 73 33.313 72.124 4.897
1.00 28.16 6 ATOM 600 C THR 73 31.824 72.223 1.371 1.00 26.31 6
ATOM 601 O THR 73 31.210 73.110 0.776 1.00 28.00 8 ATOM 602 N SER
74 31.685 70.927 1.074 1.00 28.62 7 ATOM 603 CA SER 74 30.592
70.605 0.112 1.00 29.44 6 ATOM 604 CB SER 74 31.020 69.470 -0.803
1.00 30.45 6 ATOM 605 OG SER 74 31.407 68.399 0.034 1.00 41.05 8
ATOM 606 C SER 74 29.366
70.395 0.992 1.00 26.65 6 ATOM 607 O SER 74 29.461 70.438 2.228
1.00 25.57 8 ATOM 608 N LEU 75 28.178 70.281 0.442 1.00 29.47 7
ATOM 609 CA LEU 75 26.915 70.163 1.158 1.00 25.10 6 ATOM 610 CB LEU
75 25.749 70.141 0.159 1.00 27.83 6 ATOM 611 CG LEU 75 24.348
70.136 0.777 1.00 27.24 6 ATOM 612 CD1 LEU 75 23.888 71.554 1.094
1.00 24.13 6 ATOM 613 CD2 LEU 75 23.349 69.420 -0.133 1.00 24.42 6
ATOM 614 C LEU 75 26.884 68.973 2.087 1.00 25.84 6 ATOM 615 O LEU
75 27.300 67.858 1.711 1.00 22.45 8 ATOM 616 N SER 76 26.376 69.158
3.315 1.00 23.31 7 ATOM 617 CA SER 76 26.357 68.009 4.219 1.00
25.20 6 ATOM 618 CB SER 76 25.916 68.402 5.644 1.00 26.64 6 ATOM
619 OG SER 76 24.514 68.663 5.624 1.00 29.43 8 ATOM 620 C SER 76
25.346 66.955 3.738 1.00 23.00 6 ATOM 621 O SER 76 24.431 67.304
3.006 1.00 21.02 8 ATOM 622 N ASP 77 25.506 65.739 4.241 1.00 22.24
7 ATOM 623 CA ASP 77 24.493 64.712 4.094 1.00 26.03 6 ATOM 624 CB
ASP 77 24.907 63.362 4.683 1.00 20.27 6 ATOM 625 CG ASP 77 25.914
62.676 3.758 1.00 25.73 6 ATOM 626 OD1 ASP 77 25.821 62.893 2.541
1.00 23.79 8 ATOM 627 OD2 ASP 77 26.769 61.954 4.292 1.00 28.92 8
ATOM 628 C ASP 77 23.267 65.191 4.929 1.00 25.85 6 ATOM 629 O ASP
77 23.423 65.904 5.914 1.00 24.00 8 ATOM 630 N PRO 78 22.098 64.758
4.492 1.00 27.37 7 ATOM 631 CD PRO 78 21.917 63.917 3.275 1.00
26.84 6 ATOM 632 CA PRO 78 20.849 65.130 5.098 1.00 25.42 6 ATOM
633 CB PRO 78 19.795 64.592 4.141 1.00 28.38 6 ATOM 634 CG PRO 78
20.453 63.586 3.272 1.00 27.24 6 ATOM 635 C PRO 78 20.575 64.556
6.479 1.00 25.28 6 ATOM 636 O PRO 78 21.006 63.459 6.820 1.00 23.68
8 ATOM 637 N VAL 79 19.833 65.331 7.265 1.00 20.24 7 ATOM 638 CA
VAL 79 19.287 64.861 8.535 1.00 18.86 6 ATOM 639 CB VAL 79 19.850
65.516 9.783 1.00 19.49 6 ATOM 640 CG1 VAL 79 19.042 65.239 11.046
1.00 22.25 6 ATOM 641 CG2 VAL 79 21.275 64.959 10.036 1.00 21.95 6
ATOM 642 C VAL 79 17.777 65.046 8.399 1.00 19.76 6 ATOM 643 O VAL
79 17.283 66.130 8.076 1.00 22.34 8 ATOM 644 N HIS 80 17.024 63.955
8.566 1.00 19.43 7 ATOM 645 CA HIS 80 15.584 63.976 8.387 1.00
18.11 6 ATOM 646 CB HIS 80 15.130 62.621 7.784 1.00 26.87 6 ATOM
647 CG HIS 80 13.712 62.754 7.293 1.00 31.93 6 ATOM 648 CD2 HIS 80
13.194 62.983 6.069 1.00 27.05 6 ATOM 649 ND1 HIS 80 12.637 62.697
8.176 1.00 34.35 7 ATOM 650 CE1 HIS 80 11.525 62.847 7.480 1.00
34.80 6 ATOM 651 NE2 HIS 80 11.831 63.016 6.210 1.00 34.81 7 ATOM
652 C HIS 80 14.865 64.187 9.718 1.00 23.08 6 ATOM 653 O HIS 80
15.096 63.496 10.709 1.00 23.37 8 ATOM 654 N LEU 81 13.953 65.138
9.747 1.00 19.18 7 ATOM 655 CA LEU 81 13.244 65.478 10.957 1.00
21.58 6 ATOM 656 CB LEU 81 13.567 66.937 11.331 1.00 18.20 6 ATOM
657 CG LEU 81 12.847 67.381 12.605 1.00 18.21 6 ATOM 658 CD1 LEU 81
13.496 66.708 13.812 1.00 19.39 6 ATOM 659 CD2 LEU 81 12.865 68.912
12.696 1.00 14.76 6 ATOM 660 C LEU 81 11.747 65.255 10.783 1.00
19.36 6 ATOM 661 O LEU 81 11.225 65.543 9.720 1.00 20.96 8 ATOM 662
N THR 82 11.100 64.689 11.793 1.00 19.61 7 ATOM 663 CA THR 82 9.642
64.463 11.680 1.00 18.45 6 ATOM 664 CB THR 82 9.316 62.950 11.683
1.00 25.98 6 ATOM 665 OG1 THR 82 9.907 62.351 10.527 1.00 18.89 8
ATOM 666 CG2 THR 82 7.795 62.775 11.666 1.00 24.98 6 ATOM 667 C THR
82 8.971 65.100 12.891 1.00 16.02 6 ATOM 668 O THR 82 9.248 64.735
14.035 1.00 14.79 8 ATOM 669 N VAL 83 8.075 66.045 12.647 1.00
16.23 7 ATOM 670 CA VAL 83 7.451 66.758 13.753 1.00 16.97 6 ATOM
671 CB VAL 83 7.559 68.282 13.530 1.00 12.81 6 ATOM 672 CG1 VAL 83
7.051 68.972 14.799 1.00 15.92 6 ATOM 673 CG2 VAL 83 8.986 68.760
13.246 1.00 11.78 6 ATOM 674 C VAL 83 6.020 66.264 13.892 1.00
19.97 6 ATOM 675 O VAL 83 5.261 66.329 12.918 1.00 18.57 8 ATOM 676
N LEU 84 5.686 65.756 15.075 1.00 16.89 7 ATOM 677 CA LEU 84 4.372
65.188 15.312 1.00 19.89 6 ATOM 678 CB LEU 84 4.621 63.786 15.890
1.00 18.15 6 ATOM 679 CG LEU 84 5.491 62.863 15.021 1.00 23.40 6
ATOM 680 CD1 LEU 84 5.927 61.690 15.868 1.00 25.20 6 ATOM 681 CD2
LEU 84 4.752 62.396 13.758 1.00 20.46 6 ATOM 682 C LEU 84 3.487
66.016 16.228 1.00 22.29 6 ATOM 683 O LEU 84 3.928 66.891 16.975
1.00 23.90 8 ATOM 684 N PHE 85 2.189 65.750 16.218 1.00 21.03 7
ATOM 685 CA PHE 85 1.254 66.444 17.111 1.00 22.92 6 ATOM 686 CB PHE
85 0.399 67.431 16.333 1.00 21.76 6 ATOM 687 CG PHE 85 -0.440
68.350 17.184 1.00 27.90 6 ATOM 688 CD1 PHE 85 0.103 69.013 18.266
1.00 28.30 6 ATOM 689 CD2 PHE 85 -1.787 68.533 16.899 1.00 26.61 6
ATOM 690 CE1 PHE 85 -0.664 69.874 19.040 1.00 29.65 6 ATOM 691 CE2
PHE 85 -2.559 69.386 17.668 1.00 25.61 6 ATOM 692 CZ PHE 85 -1.996
70.047 18.733 1.00 28.75 6 ATOM 693 C PHE 85 0.455 65.399 17.852
1.00 21.99 6 ATOM 694 O PHE 85 -0.642 65.000 17.426 1.00 22.11 8
ATOM 695 N GLU 86 1.023 64.883 18.938 1.00 20.76 7 ATOM 696 CA GLU
86 0.421 63.762 19.702 1.00 18.04 6 ATOM 697 CB GLU 86 1.142 62.463
19.210 1.00 20.84 6 ATOM 698 CG GLU 86 0.711 61.815 17.911 1.00
25.05 6 ATOM 699 CD GLU 86 1.647 61.048 17.019 1.00 41.96 6 ATOM
700 OE1 GLU 86 2.719 60.507 17.416 1.00 46.14 8 ATOM 701 OE2 GLU 86
1.429 60.893 15.765 1.00 40.77 8 ATOM 702 C GLU 86 0.694 64.026
21.176 1.00 18.46 6 ATOM 703 O GLU 86 1.588 64.839 21.462 1.00
16.67 8 ATOM 704 N TRP 87 0.031 63.408 22.156 1.00 12.60 7 ATOM 705
CA TRP 87 0.328 63.631 23.553 1.00 13.01 6 ATOM 706 CB TRP 87
-0.808 63.056 24.411 1.00 18.40 6 ATOM 707 CG TRP 87 -1.922 64.023
24.687 1.00 21.87 6 ATOM 708 CD2 TRP 87 -1.812 65.176 25.521 1.00
21.14 6 ATOM 709 CE2 TRP 87 -3.065 65.805 25.526 1.00 24.31 6 ATOM
710 CE3 TRP 87 -0.767 65.738 26.255 1.00 24.84 6 ATOM 711 CD1 TRP
87 -3.216 63.985 24.231 1.00 22.52 6 ATOM 712 NE1 TRP 87 -3.907
65.069 24.734 1.00 22.53 7 ATOM 713 CZ2 TRP 87 -3.303 66.966 26.266
1.00 29.91 6 ATOM 714 CZ3 TRP 87 -0.998 66.890 26.987 1.00 29.83 6
ATOM 715 CH2 TRP 87 -2.254 67.499 26.970 1.00 29.09 6 ATOM 716 C
TRP 87 1.599 62.967 24.068 1.00 15.44 6 ATOM 717 O TRP 87 2.178
63.499 25.018 1.00 16.68 8 ATOM 718 N LEU 88 2.036 61.873 23.447
1.00 14.44 7 ATOM 719 CA LEU 88 3.153 61.051 23.861 1.00 20.07 6
ATOM 720 CB LEU 88 2.596 59.942 24.783 1.00 17.49 6 ATOM 721 CG LEU
88 3.608 59.303 25.769 1.00 16.97 6 ATOM 722 CD1 LEU 88 4.062
60.299 26.830 1.00 17.38 6 ATOM 723 CD2 LEU 88 2.987 58.053 26.370
1.00 13.93 6 ATOM 724 C LEU 88 3.889 60.399 22.677 1.00 20.44 6
ATOM 725 O LEU 88 3.255 59.857 21.752 1.00 19.65 8 ATOM 726 N VAL
89 5.218 60.517 22.620 1.00 18.11 7 ATOM 727 CA VAL 89 5.998 59.926
21.542 1.00 14.66 6 ATOM 728 CBA VAL 89 6.686 61.029 20.699 0.50
7.52 6 ATOM 729 CBB VAL 89 6.677 60.941 20.604 0.50 13.86 6 ATOM
730 CG1 VAL 89 7.573 61.890 21.597 0.50 7.13 6 ATOM 731 CG1 VAL 89
5.696 61.409 19.543 0.50 15.87 6 ATOM 732 CG2 VAL 89 7.501 60.486
19.531 0.50 3.91 6 ATOM 733 CG2 VAL 89 7.264 62.090 21.402 0.50
18.65 6 ATOM 734 C VAL 89 7.109 59.032 22.107 1.00 15.71 6 ATOM 735
O VAL 89 7.689 59.262 23.179 1.00 14.52 8 ATOM 736 N LEU 90 7.379
57.958 21.386 1.00 15.13 7 ATOM 737 CA LEU 90 8.520 57.133 21.703
1.00 13.72 6 ATOM 738 CB LEU 90 8.287 55.625 21.488 1.00 17.87 6
ATOM 739 CG LEU 90 9.650 54.978 21.873 1.00 26.07 6 ATOM 740 CD1
LEU 90 9.479 54.066 23.036 1.00 30.57 6 ATOM 741 CD2 LEU 90 10.373
54.463 20.662 1.00 25.07 6 ATOM 742 C LEU 90 9.657 57.674 20.803
1.00 17.58 6 ATOM 743 O LEU 90 9.611 57.517 19.576 1.00 14.46 8
ATOM 744 N GLN 91 10.673 58.298 21.412 1.00 15.83 7 ATOM 745 CA GLN
91 11.745 58.908 20.623 1.00 17.70 6 ATOM 746 CB GLN 91 12.252
60.238 21.264 1.00 15.03 6 ATOM 747 CG GLN 91 11.105 61.231 21.472
1.00 12.81 6 ATOM 748 CD GLN 91 11.564 62.636 21.868 1.00 15.79 6
ATOM 749 OE1 GLN 91 12.023 62.823 22.988 1.00 14.61 8 ATOM 750 NE2
GLN 91 11.409 63.610 20.984 1.00 16.27 7 ATOM 751 C GLN 91 12.971
58.042 20.375 1.00 17.71 6 ATOM 752 O GLN 91 13.370 57.296 21.268
1.00 19.37 8 ATOM 753 N THR 92 13.607 58.207 19.218 1.00 14.05 7
ATOM 754 CA THR 92 14.853 57.488 18.934 1.00 19.01 6 ATOM 755 CB
THR 92 14.562 56.225 18.089 1.00 16.40 6 ATOM 756 OG1 THR 92 15.769
55.485 17.905 1.00 18.39 8 ATOM 757 CG2 THR 92 13.943 56.499 16.720
1.00 10.45 6 ATOM 758 C THR 92 15.803 58.416 18.173 1.00 18.96 6
ATOM 759 O THR 92 15.339 59.272 17.409 1.00 21.88 8 ATOM 760 N PRO
93 17.095 58.153 18.251 1.00 18.78 7 ATOM 761 CD PRO 93 17.747
57.169 19.135 1.00 22.16 6 ATOM 762 CA PRO 93 18.090 58.929 17.530
1.00 24.37 6 ATOM 763 CB PRO 93 19.352 58.803 18.371 1.00 24.99 6
ATOM 764 CG PRO 93 19.162 57.609 19.235 1.00 26.05 6 ATOM 765 C PRO
93 18.285 58.362 16.138 1.00 27.02 6 ATOM 766 O PRO 93 18.852
59.019 15.248 1.00 27.04 8 ATOM 767 N HIS 94 17.978 57.069 15.960
1.00 24.22 7 ATOM 768 CA HIS 94 18.114 56.421 14.651 1.00 25.72 6
ATOM 769 CB HIS 94 19.444 55.690 14.439 1.00 20.09 6 ATOM 770 CG
HIS 94 20.639 56.587 14.595 1.00 21.67 6 ATOM 771 CD2 HIS 94 21.161
57.530 13.798 1.00 23.30 6 ATOM 772 ND1 HIS 94 21.380 56.595 15.754
1.00 27.49 7 ATOM 773 CE1 HIS 94 22.338 57.501 15.657 1.00 26.54 6
ATOM 774 NE2 HIS 94 22.211 58.078 14.482 1.00 32.10 7 ATOM 775 C
HIS 94 17.038 55.350 14.453 1.00 24.49 6 ATOM 776 O HIS 94 16.481
54.838 15.429 1.00 24.01 8 ATOM 777 N LEU 95 16.847 54.929 13.214
1.00 21.96 7 ATOM 778 CA LEU 95 15.900 53.847 12.960 1.00 26.06 6
ATOM 779 CB LEU 95 15.014 54.118 11.741 1.00 26.66 6 ATOM 780 CG
LEU 95 13.994 55.248 11.899 1.00 35.19 6 ATOM 781 CD1 LEU 95 13.449
55.601 10.525 1.00 25.66 6 ATOM 782 CD2 LEU 95 12.895 54.908 12.900
1.00 24.13 6 ATOM 783 C LEU 95 16.626 52.525 12.720 1.00 26.30 6
ATOM 784 O LEU 95 15.999 51.464 12.790 1.00 26.83 8 ATOM 785 N GLU
96 17.884 52.601 12.326 1.00 25.44 7 ATOM 786 CA GLU 96 18.688
51.413 12.087 1.00 28.55 6 ATOM 787 CB GLU 96 19.062 51.144 10.634
1.00 28.97 6 ATOM 788 CG GLU 96 17.977 51.334 9.605 1.00 34.46 6
ATOM 789 CD GLU 96 18.414 51.109 8.168 1.00 42.07 6 ATOM 790 OE1
GLU 96 19.560 50.709 7.882 1.00 41.53 8 ATOM 791 OE2 GLU 96 17.592
51.343 7.256 1.00 45.31 8 ATOM 792 C GLU 96 19.995 51.575 12.885
1.00 32.22 6 ATOM 793 O GLU 96 20.525 52.686 13.015 1.00 31.68 8
ATOM 794 N PHE 97 20.396 50.487 13.538 1.00 29.38 7 ATOM 795 CA PHE
97 21.622 50.447 14.315 1.00 31.45 6 ATOM 796 CB PHE 97 21.388
50.351 15.832 1.00 29.88 6 ATOM 797 CG PHE 97 20.640 51.497 16.464
1.00 28.91 6 ATOM 798 CD1 PHE 97 19.256 51.580 16.386 1.00 19.88 6
ATOM 799 CD2 PHE 97 21.311 52.503 17.131 1.00 27.06 6 ATOM 800 CE1
PHE 97 18.557 52.624 16.971 1.00 23.29 6 ATOM 801 CE2 PHE 97 20.622
53.545 17.719 1.00 23.27 6 ATOM 802 CZ PHE 97 19.244 53.626 17.636
1.00 25.87 6 ATOM 803 C PHE 97 22.455 49.233 13.861 1.00 31.11 6
ATOM 804 O PHE 97 22.007 48.334 13.164 1.00 32.31 8 ATOM 805 N GLN
98 23.726 49.213 14.219 1.00 34.14 7 ATOM 806 CA GLN 98 24.636
48.131 13.939 1.00 33.31 6 ATOM 807 CB GLN 98 26.042 48.629 13.635
1.00 38.15 6 ATOM 808 CG GLN 98 26.207 49.422 12.356 1.00 45.65 6
ATOM 809 CD GLN 98 25.763 48.712 11.097 1.00 49.99 6 ATOM 810 OE1
GLN 98 26.455 47.828 10.589 1.00 52.58 8 ATOM 811 NE2 GLN 98 24.603
49.088 10.563 1.00 53.06 7 ATOM 812 C GLN 98 24.662 47.218 15.172
1.00 31.48 6 ATOM 813 O GLN 98 24.459 47.664 16.300 1.00 27.98 8
ATOM 814 N GLU 99 24.990 45.955 14.920 1.00 30.75 7 ATOM 815 CA GLU
99 25.112 44.978 16.009 1.00 32.56 6 ATOM 816 CB GLU 99 25.598
43.653 15.420 1.00 36.89 6 ATOM 817 CG GLU 99 25.204 42.392 16.141
1.00 44.86 6 ATOM 818 CD GLU 99 24.771 41.288 15.184 1.00 48.45 6
ATOM 819 OE1 GLU 99 23.802 40.573 15.521 1.00 53.90 8 ATOM 820 OE2
GLU 99 25.400 41.148 14.118 1.00 50.56 8 ATOM 821 C GLU 99 26.130
45.551 16.980 1.00 31.14 6 ATOM 822 O GLU 99 27.136 46.048 16.475
1.00 31.94 8 ATOM 823 N GLY 100 25.919 45.571 18.275 1.00 32.19 7
ATOM 824 CA GLY 100 26.874 46.123 19.217 1.00 31.10 6 ATOM 825 C
GLY 100 26.643 47.541 19.696 1.00 31.51 6 ATOM 826 O GLY 100 27.082
47.931 20.789 1.00 30.30 8 ATOM 827 N GLU 101 25.948 48.369 18.921
1.00 34.41 7 ATOM 828 CA GLU 101 25.675 49.746 19.297 1.00 34.07 6
ATOM 829 CB GLU 101 24.949 50.452 18.148 1.00 37.86 6 ATOM 830 CG
GLU 101 25.777 50.676 16.889 1.00 48.38 6 ATOM 831 CD GLU 101
24.984 51.520 15.895 1.00 49.17 6 ATOM 832 OE1 GLU 101 24.251
52.408 16.385 1.00 58.51 8 ATOM 833 OE2 GLU 101 25.046 51.333
14.669 1.00 48.56 8 ATOM 834 C GLU 101 24.783 49.848 20.537 1.00
33.06 6 ATOM 835 O GLU 101 24.086 48.888 20.886 1.00 27.70 8 ATOM
836 N THR 102 24.747 51.057 21.107 1.00 31.92 7 ATOM 837 CA THR 102
23.870 51.303 22.248 1.00 32.85 6 ATOM 838 CB THR 102 24.508 52.161
23.341 1.00 35.75 6 ATOM 839 OG1 THR 102 25.546 51.438 24.021 1.00
36.79 8 ATOM 840 CG2 THR 102 23.532 52.577 24.441 1.00 35.82 6 ATOM
841 C THR 102 22.582 51.944 21.721 1.00 32.54 6 ATOM 842 O THR 102
22.650 52.932 20.991 1.00 30.03 8 ATOM 843 N ILE 103 21.431 51.329
22.014 1.00 28.53 7 ATOM 844 CA ILE 103 20.162 51.939 21.590 1.00
25.40 6 ATOM 845 CB ILE 103 19.131 50.873 21.163 1.00 26.58 6 ATOM
846 CG2 ILE 103 17.776 51.496 20.828 1.00 25.47 6 ATOM 847 CG1 ILE
103 19.669 50.080 19.971 1.00 21.79 6 ATOM 848 CD1 ILE 103 18.739
49.003 19.438 1.00 19.73 6 ATOM 849 C ILE 103 19.624 52.753 22.767
1.00 25.27 6 ATOM 850 O ILE 103 19.439 52.181 23.853 1.00 23.06 8
ATOM 851 N MET 104 19.443 54.059 22.591 1.00 24.90 7 ATOM 852 CA
MET 104 18.893 54.913 23.639 1.00 21.55 6 ATOM 853 CB MET 104
19.797 56.097 23.963 1.00 33.48 6 ATOM 854 CG MET 104 20.810 55.826
25.101 1.00 29.68 6 ATOM 855 SD MET 104 21.940 57.256 25.242 1.00
46.02 16 ATOM 856 CE MET 104 22.667 57.216 23.589 1.00 31.10 6 ATOM
857 C MET 104 17.528 55.456 23.215 1.00 21.27 6 ATOM 858 O MET 104
17.374 55.991 22.106 1.00 22.96 8 ATOM 859 N LEU 105 16.503 55.242
24.027 1.00 20.55 7 ATOM 860 CA LEU 105 15.134 55.668 23.728 1.00
22.33 6 ATOM 861 CB LEU 105 14.192 54.450 23.550 1.00 14.66 6 ATOM
862 CG LEU 105 14.713 53.389 22.561 1.00 18.89 6 ATOM 863 CD1 LEU
105 13.796 52.178 22.489 1.00 19.44 6 ATOM 864 CD2 LEU 105 14.882
54.056 21.186 1.00 18.70 6 ATOM 865 C LEU 105 14.567 56.559 24.817
1.00 20.15 6 ATOM 866 O LEU 105 15.050 56.506 25.950 1.00 18.39 8
ATOM 867 N ARG 106 13.523 57.324 24.483 1.00 18.25 7 ATOM 868 CA
ARG 106 12.912 58.174 25.516 1.00 17.87 6 ATOM 869 CB ARG 106
13.607 59.553 25.508 1.00 14.96 6 ATOM 870 CG ARG 106 12.834 60.597
26.290 1.00 16.79 6 ATOM 871 CD ARG 106 13.699 61.788 26.757 1.00
19.51 6 ATOM 872 NE ARG 106 13.334 62.927 26.025 1.00 23.46 7 ATOM
873 CZ ARG 106 12.990 64.174 26.065 1.00 24.43 6 ATOM 874 NH1 ARG
106 12.923 64.892 27.176 1.00 25.93 7 ATOM 875 NH2 ARG 106 12.697
64.795 24.936 1.00 18.72 7 ATOM 876 C ARG 106 11.422 58.321 25.304
1.00 18.56 6 ATOM 877 O ARG 106 10.998 58.479 24.142 1.00 20.43 8
ATOM 878 N CYS 107 10.642 58.246 26.378 1.00 15.23 7 ATOM 879 CA
CYS 107 9.189 58.419 26.292 1.00 14.89 6 ATOM 880 C CYS 107 8.934
59.891 26.583 1.00 15.28 6 ATOM 881 O CYS 107 9.296 60.294 27.690
1.00 15.96 8 ATOM 882 CB CYS 107 8.438 57.565 27.322 1.00 14.55 6
ATOM 883 SG CYS 107 6.691 57.368 27.013 1.00 13.91 16 ATOM 884 N
HIS 108 8.446 60.653 25.604 1.00 15.07 7 ATOM 885 CA HIS 108 8.334
62.103 25.811 1.00 11.91 6 ATOM 886 CB HIS 108 9.190 62.757 24.708
1.00 16.03 6 ATOM 887 CG HIS 108 9.119 64.240 24.572 1.00 16.94 6
ATOM 888 CD2 HIS 108 9.068 65.023 23.462 1.00 17.64 6 ATOM 889 ND1
HIS 108 9.103 65.108 25.657 1.00 17.41 7 ATOM 890 CE1 HIS 108 9.034
66.350 25.215 1.00 17.37 6 ATOM 891 NE2 HIS 108 9.021 66.333 23.895
1.00 20.00 7 ATOM 892 C HIS 108 6.925 62.647 25.733 1.00 11.83 6
ATOM 893 O HIS 108 6.224 62.361 24.762 1.00 12.54 8 ATOM 894 N SER
109 6.515 63.502 26.654 1.00 13.70 7 ATOM 895 CA SER 109 5.160
64.091 26.605 1.00 11.70 6 ATOM 896 CB SER 109 4.583 64.134 28.041
1.00 13.47 6 ATOM 897 OG SER 109 5.609 64.845 28.800 1.00 16.16 8
ATOM 898 C SER 109 5.190 65.459 25.970 1.00 14.21 6 ATOM 899 O SER
109 6.180 66.232 25.903 1.00 14.63 8 ATOM 900 N TRP 110 4.047
65.804 25.381 1.00 16.58 7 ATOM 901 CA TRP 110 3.860 67.102 24.708
1.00 16.04 6 ATOM 902 CB TRP 110 2.480 67.158 24.072 1.00 18.73 6
ATOM 903 CG TRP 110 2.187 68.425 23.306 1.00 21.24 6 ATOM 904 CD2
TRP 110 1.135 69.339 23.589 1.00 20.70 6 ATOM 905 CE2 TRP 110 1.193
70.361 22.616 1.00 25.92 6 ATOM 906 CE3 TRP 110 0.112 69.372 24.549
1.00 24.16 6 ATOM 907 CD1 TRP 110 2.827 68.908 22.214 1.00 22.22 6
ATOM 908 NE1 TRP 110 2.233 70.069 21.765 1.00 22.81 7 ATOM 909 CZ2
TRP 110 0.276 71.404
22.568 1.00 24.18 6 ATOM 910 CZ3 TRP 110 -0.781 70.434 24.509 1.00
30.15 6 ATOM 911 CH2 TRP 110 -0.698 71.433 23.526 1.00 31.04 6 ATOM
912 C TRP 110 4.082 68.245 25.681 1.00 14.44 6 ATOM 913 O TRP 110
3.665 68.219 26.852 1.00 17.08 8 ATOM 914 N LYS 111 4.928 69.199
25.294 1.00 19.42 7 ATOM 915 CA LYS 111 5.347 70.325 26.115 1.00
19.40 6 ATOM 916 CB LYS 111 4.131 71.241 26.418 1.00 21.00 6 ATOM
917 CG LYS 111 3.583 71.904 25.155 1.00 24.94 6 ATOM 918 CD LYS 111
2.124 72.287 25.337 1.00 34.17 6 ATOM 919 CE LYS 111 1.952 73.719
25.781 1.00 37.49 6 ATOM 920 NZ LYS 111 2.783 74.668 24.987 1.00
52.66 7 ATOM 921 C LYS 111 5.940 69.921 27.450 1.00 20.33 6 ATOM
922 O LYS 111 5.905 70.694 28.419 1.00 16.80 8 ATOM 923 N ASP 112
6.444 68.695 27.602 1.00 18.28 7 ATOM 924 CA ASP 112 6.989 68.233
28.861 1.00 20.31 6 ATOM 925 CB ASP 112 8.242 69.088 29.191 1.00
24.52 6 ATOM 926 CG ASP 112 9.306 68.737 28.155 1.00 31.39 6 ATOM
927 OD1 ASP 112 9.700 67.545 28.119 1.00 39.68 8 ATOM 928 OD2 ASP
112 9.719 69.588 27.360 1.00 35.00 8 ATOM 929 C ASP 112 6.015
68.203 30.018 1.00 23.40 6 ATOM 930 O ASP 112 6.426 68.475 31.148
1.00 23.42 8 ATOM 931 N LYS 113 4.731 67.889 29.785 1.00 23.10 7
ATOM 932 CA LYS 113 3.792 67.721 30.891 1.00 22.35 6 ATOM 933 CB
LYS 113 2.352 67.432 30.437 1.00 21.68 6 ATOM 934 CG LYS 113 1.758
68.611 29.659 1.00 27.09 6 ATOM 935 CD LYS 113 0.232 68.574 29.608
1.00 28.34 6 ATOM 936 CE LYS 113 -0.269 69.780 28.816 1.00 32.92 6
ATOM 937 NZ LYS 113 -0.196 71.075 29.554 1.00 33.55 7 ATOM 938 C
LYS 113 4.352 66.597 31.748 1.00 19.86 6 ATOM 939 O LYS 113 4.890
65.603 31.264 1.00 21.45 8 ATOM 940 N PRO 114 4.288 66.761 33.066
1.00 20.08 7 ATOM 941 CD PRO 114 3.701 67.928 33.768 1.00 16.95 6
ATOM 942 CA PRO 114 4.923 65.801 33.957 1.00 17.00 6 ATOM 943 CB
PRO 114 4.548 66.292 35.342 1.00 19.22 6 ATOM 944 CG PRO 114 4.169
67.733 35.176 1.00 21.34 6 ATOM 945 C PRO 114 4.451 64.405 33.636
1.00 16.83 6 ATOM 946 O PRO 114 3.237 64.125 33.512 1.00 16.01 8
ATOM 947 N LEU 115 5.414 63.483 33.560 1.00 15.95 7 ATOM 948 CA LEU
115 5.081 62.104 33.215 1.00 17.10 6 ATOM 949 CB LEU 115 5.769
61.879 31.856 1.00 16.83 6 ATOM 950 CG LEU 115 5.790 60.498 31.231
1.00 21.64 6 ATOM 951 CD1 LEU 115 4.399 60.132 30.733 1.00 19.24 6
ATOM 952 CD2 LEU 115 6.777 60.486 30.043 1.00 19.80 6 ATOM 953 C
LEU 115 5.606 61.116 34.226 1.00 21.13 6 ATOM 954 O LEU 115 6.788
61.200 34.569 1.00 18.84 8 ATOM 955 N VAL 116 4.839 60.105 34.630
1.00 20.51 7 ATOM 956 CA VAL 116 5.314 59.073 35.545 1.00 20.40 6
ATOM 957 CB VAL 116 4.787 59.277 36.971 1.00 18.72 6 ATOM 958 CG1
VAL 116 5.313 60.547 37.644 1.00 22.67 6 ATOM 959 CG2 VAL 116 3.257
59.328 36.998 1.00 22.12 6 ATOM 960 C VAL 116 4.807 57.703 35.073
1.00 19.73 6 ATOM 961 O VAL 116 3.910 57.682 34.223 1.00 20.76 8
ATOM 962 N LYS 117 5.268 56.615 35.693 1.00 17.34 7 ATOM 963 CA LYS
117 4.760 55.290 35.381 1.00 20.33 6 ATOM 964 CB LYS 117 3.271
55.182 35.802 1.00 21.74 6 ATOM 965 CG LYS 117 3.115 54.927 37.301
1.00 24.43 6 ATOM 966 CD LYS 117 1.793 55.445 37.832 1.00 32.69 6
ATOM 967 CE LYS 117 0.798 54.314 38.056 1.00 40.27 6 ATOM 968 NZ
LYS 117 -0.568 54.865 38.266 1.00 44.06 7 ATOM 969 C LYS 117 4.956
54.936 33.914 1.00 18.58 6 ATOM 970 O LYS 117 4.026 54.535 33.234
1.00 24.35 8 ATOM 971 N VAL 118 6.181 55.063 33.417 1.00 20.45 7
ATOM 972 CA VAL 118 6.542 54.798 32.039 1.00 19.15 6 ATOM 973 CB
VAL 118 7.756 55.643 31.607 1.00 12.17 6 ATOM 974 CG1 VAL 118 8.199
55.396 30.176 1.00 18.94 6 ATOM 975 CG2 VAL 118 7.408 57.129 31.794
1.00 16.75 6 ATOM 976 C VAL 118 6.868 53.330 31.797 1.00 18.58 6
ATOM 977 O VAL 118 7.606 52.717 32.564 1.00 17.16 8 ATOM 978 N THR
119 6.307 52.803 30.711 1.00 15.94 7 ATOM 979 CA THR 119 6.527
51.425 30.335 1.00 16.50 6 ATOM 980 CB THR 119 5.291 50.523 30.367
1.00 19.59 6 ATOM 981 OG1 THR 119 4.770 50.410 31.693 1.00 23.11 8
ATOM 982 CG2 THR 119 5.695 49.123 29.872 1.00 24.83 6 ATOM 983 C
THR 119 7.053 51.424 28.881 1.00 17.81 6 ATOM 984 O THR 119 6.436
52.130 28.095 1.00 14.36 8 ATOM 985 N PHE 120 8.121 50.679 28.643
1.00 14.86 7 ATOM 986 CA PHE 120 8.616 50.608 27.259 1.00 13.85 6
ATOM 987 CB PHE 120 10.122 50.797 27.240 1.00 15.51 6 ATOM 988 CG
PHE 120 10.553 52.230 27.463 1.00 13.38 6 ATOM 989 CD1 PHE 120
10.748 52.701 28.750 1.00 20.15 6 ATOM 990 CD2 PHE 120 10.792
53.051 26.381 1.00 20.08 6 ATOM 991 CE1 PHE 120 11.186 54.002
28.953 1.00 17.14 6 ATOM 992 CE2 PHE 120 11.230 54.367 26.578 1.00
22.12 6 ATOM 993 CZ PHE 120 11.423 54.818 27.867 1.00 17.10 6 ATOM
994 C PHE 120 8.279 49.216 26.721 1.00 17.13 6 ATOM 995 O PHE 120
8.640 48.221 27.407 1.00 14.78 8 ATOM 996 N PHE 121 7.626 49.166
25.575 1.00 16.20 7 ATOM 997 CA PHE 121 7.277 47.868 25.011 1.00
18.83 6 ATOM 998 CB PHE 121 5.799 47.821 24.616 1.00 13.50 6 ATOM
999 CG PHE 121 4.768 48.052 25.656 1.00 18.60 6 ATOM 1000 CD1 PHE
121 4.368 49.339 26.017 1.00 17.37 6 ATOM 1001 CD2 PHE 121 4.208
46.961 26.334 1.00 18.44 6 ATOM 1002 CE1 PHE 121 3.409 49.524
27.006 1.00 19.78 6 ATOM 1003 CE2 PHE 121 3.260 47.173 27.313 1.00
22.69 6 ATOM 1004 CZ PHE 121 2.843 48.445 27.660 1.00 15.74 6 ATOM
1005 C PHE 121 8.074 47.539 23.749 1.00 18.44 6 ATOM 1006 O PHE 121
8.351 48.454 22.987 1.00 15.63 8 ATOM 1007 N GLN 122 8.333 46.253
23.480 1.00 19.35 7 ATOM 1008 CA GLN 122 8.959 45.880 22.203 1.00
19.90 6 ATOM 1009 CB GLN 122 10.396 45.379 22.317 1.00 16.32 6 ATOM
1010 CG GLN 122 10.784 44.583 21.065 1.00 18.39 6 ATOM 1011 CD GLN
122 12.050 43.764 21.247 1.00 21.98 6 ATOM 1012 OE1 GLN 122 12.423
43.461 22.374 1.00 19.18 8 ATOM 1013 NE2 GLN 122 12.700 43.396
20.153 1.00 24.51 7 ATOM 1014 C GLN 122 8.067 44.774 21.609 1.00
15.34 6 ATOM 1015 O GLN 122 7.789 43.832 22.321 1.00 17.30 8 ATOM
1016 N ASN 123 7.474 44.931 20.439 1.00 18.98 7 ATOM 1017 CA ASN
123 6.542 43.975 19.859 1.00 22.95 6 ATOM 1018 CB ASN 123 7.241
42.708 19.332 1.00 19.57 6 ATOM 1019 CG ASN 123 8.228 43.130 18.244
1.00 26.31 6 ATOM 1020 OD1 ASN 123 8.013 44.053 17.441 1.00 19.76 8
ATOM 1021 ND2 ASN 123 9.375 42.463 18.213 1.00 28.57 7 ATOM 1022 C
ASN 123 5.397 43.643 20.803 1.00 21.02 6 ATOM 1023 O ASN 123 4.911
42.525 20.918 1.00 19.19 8 ATOM 1024 N GLY 124 4.951 44.632 21.579
1.00 19.77 7 ATOM 1025 CA GLY 124 3.852 44.516 22.495 1.00 16.41 6
ATOM 1026 C GLY 124 4.159 43.885 23.844 1.00 14.85 6 ATOM 1027 O
GLY 124 3.210 43.658 24.611 1.00 15.05 8 ATOM 1028 N LYS 125 5.405
43.610 24.133 1.00 13.81 7 ATOM 1029 CA LYS 125 5.830 42.997 25.379
1.00 21.18 6 ATOM 1030 CB LYS 125 6.700 41.738 25.247 1.00 14.85 6
ATOM 1031 CG LYS 125 6.934 41.032 26.559 1.00 16.28 6 ATOM 1032 CD
LYS 125 7.406 39.587 26.281 1.00 22.51 6 ATOM 1033 CE LYS 125 7.925
38.989 27.587 1.00 30.62 6 ATOM 1034 NZ LYS 125 8.822 37.818 27.330
1.00 36.72 7 ATOM 1035 C LYS 125 6.725 44.014 26.121 1.00 18.20 6
ATOM 1036 O LYS 125 7.648 44.525 25.509 1.00 19.98 8 ATOM 1037 N
SER 126 6.385 44.216 27.393 1.00 17.62 7 ATOM 1038 CA SER 126 7.107
45.241 28.155 1.00 20.03 6 ATOM 1039 CB SER 126 6.355 45.459 29.485
1.00 23.22 6 ATOM 1040 OG SER 126 7.317 45.773 30.466 1.00 38.12 8
ATOM 1041 C SER 126 8.541 44.823 28.389 1.00 17.85 6 ATOM 1042 O
SER 126 8.842 43.657 28.647 1.00 21.31 8 ATOM 1043 N GLN 127 9.490
45.718 28.254 1.00 17.16 7 ATOM 1044 CA GLN 127 10.898 45.515
28.408 1.00 17.45 6 ATOM 1045 CB GLN 127 11.723 46.073 27.225 1.00
20.82 6 ATOM 1046 CG GLN 127 11.352 45.419 25.897 1.00 18.56 6 ATOM
1047 CD GLN 127 11.497 43.912 25.927 1.00 24.44 6 ATOM 1048 OE1 GLN
127 12.606 43.416 26.116 1.00 31.62 8 ATOM 1049 NE2 GLN 127 10.436
43.130 25.773 1.00 19.15 7 ATOM 1050 C GLN 127 11.386 46.251 29.661
1.00 20.94 6 ATOM 1051 O GLN 127 12.439 45.929 30.179 1.00 18.25 8
ATOM 1052 N LYS 128 10.643 47.285 30.032 1.00 21.18 7 ATOM 1053 CA
LYS 128 11.070 48.048 31.216 1.00 23.10 6 ATOM 1054 CB LYS 128
12.177 49.034 30.842 1.00 21.83 6 ATOM 1055 CG LYS 128 12.683
49.882 32.013 1.00 24.67 6 ATOM 1056 CD LYS 128 13.739 50.905
31.589 1.00 18.23 6 ATOM 1057 CE LYS 128 14.048 51.746 32.870 1.00
27.02 6 ATOM 1058 NZ LYS 128 15.081 52.794 32.574 1.00 24.24 7 ATOM
1059 C LYS 128 9.884 48.844 31.754 1.00 24.93 6 ATOM 1060 O LYS 128
9.193 49.481 30.960 1.00 20.79 8 ATOM 1061 N PHE 129 9.678 48.822
33.062 1.00 21.39 7 ATOM 1062 CA PHE 129 8.708 49.695 33.695 1.00
24.45 6 ATOM 1063 CB PHE 129 7.610 48.926 34.458 1.00 25.50 6 ATOM
1064 CG PHE 129 6.772 49.837 35.327 1.00 25.51 6 ATOM 1065 CD1 PHE
129 5.799 50.630 34.762 1.00 19.40 6 ATOM 1066 CD2 PHE 129 7.002
49.928 36.700 1.00 29.98 6 ATOM 1067 CE1 PHE 129 5.026 51.491
35.535 1.00 25.00 6 ATOM 1068 CE2 PHE 129 6.249 50.788 37.491 1.00
28.84 6 ATOM 1069 CZ PHE 129 5.262 51.574 36.902 1.00 32.29 6 ATOM
1070 C PHE 129 9.480 50.577 34.687 1.00 27.88 6 ATOM 1071 O PHE 129
10.388 50.049 35.359 1.00 30.99 8 ATOM 1072 N SER 130 9.134 51.846
34.853 1.00 26.67 7 ATOM 1073 CA SER 130 9.779 52.641 35.917 1.00
24.98 6 ATOM 1074 CB SER 130 11.025 53.344 35.422 1.00 21.29 6 ATOM
1075 OG SER 130 11.271 54.465 36.250 1.00 25.72 8 ATOM 1076 C SER
130 8.777 53.667 36.434 1.00 24.39 6 ATOM 1077 O SER 130 8.123
54.285 35.576 1.00 24.91 8 ATOM 1078 N HIS 131 8.668 53.889 37.730
1.00 22.12 7 ATOM 1079 CA HIS 131 7.710 54.901 38.204 1.00 23.65 6
ATOM 1080 CB HIS 131 7.604 54.918 39.737 1.00 28.35 6 ATOM 1081 CG
HIS 131 6.859 53.706 40.197 1.00 23.57 6 ATOM 1082 CD2 HIS 131
7.307 52.509 40.642 1.00 18.55 6 ATOM 1083 ND1 HIS 131 5.478 53.666
40.170 1.00 26.69 7 ATOM 1084 CE1 HIS 131 5.095 52.478 40.617 1.00
16.65 6 ATOM 1085 NE2 HIS 131 6.173 51.764 40.890 1.00 23.94 7 ATOM
1086 C HIS 131 8.108 56.314 37.814 1.00 23.89 6 ATOM 1087 O HIS 131
7.261 57.205 37.712 1.00 26.21 8 ATOM 1088 N LEU 132 9.426 56.548
37.689 1.00 21.77 7 ATOM 1089 CA LEU 132 9.886 57.900 37.480 1.00
20.70 6 ATOM 1090 CB LEU 132 10.630 58.361 38.760 1.00 30.28 6 ATOM
1091 CG LEU 132 10.022 58.084 40.148 1.00 26.56 6 ATOM 1092 CD1 LEU
132 11.073 58.316 41.229 1.00 29.07 6 ATOM 1093 CD2 LEU 132 8.814
58.980 40.435 1.00 24.99 6 ATOM 1094 C LEU 132 10.762 58.144 36.279
1.00 22.94 6 ATOM 1095 O LEU 132 10.794 59.326 35.900 1.00 22.01 8
ATOM 1096 N ASP 133 11.541 57.181 35.778 1.00 21.75 7 ATOM 1097 CA
ASP 133 12.469 57.401 34.679 1.00 24.62 6 ATOM 1098 CB ASP 133
13.560 56.327 34.854 1.00 29.71 6 ATOM 1099 CG ASP 133 14.734
56.321 33.915 1.00 32.90 6 ATOM 1100 OD1 ASP 133 14.837 57.254
33.083 1.00 32.91 8 ATOM 1101 OD2 ASP 133 15.597 55.394 34.000 1.00
36.01 8 ATOM 1102 C ASP 133 11.843 57.230 33.296 1.00 25.88 6 ATOM
1103 O ASP 133 11.419 56.136 32.940 1.00 24.36 8 ATOM 1104 N PRO
134 11.857 58.261 32.460 1.00 24.65 7 ATOM 1105 CD PRO 134 12.347
59.620 32.778 1.00 22.97 6 ATOM 1106 CA PRO 134 11.293 58.185
31.112 1.00 24.00 6 ATOM 1107 CB PRO 134 10.889 59.662 30.870 1.00
24.02 6 ATOM 1108 CG PRO 134 11.987 60.433 31.544 1.00 23.04 6 ATOM
1109 C PRO 134 12.256 57.764 30.017 1.00 22.11 6 ATOM 1110 O PRO
134 11.970 57.930 28.824 1.00 19.00 8 ATOM 1111 N THR 135 13.420
57.212 30.350 1.00 21.43 7 ATOM 1112 CA THR 135 14.424 56.805
29.401 1.00 24.98 6 ATOM 1113 CB THR 135 15.748 57.584 29.593 1.00
27.24 6 ATOM 1114 OG1 THR 135 16.331 57.065 30.796 1.00 24.99 8
ATOM 1115 CG2 THR 135 15.461 59.069 29.706 1.00 26.07 6 ATOM 1116 C
THR 135 14.747 55.312 29.451 1.00 23.58 6 ATOM 1117 O THR 135
14.445 54.629 30.423 1.00 26.14 8 ATOM 1118 N PHE 136 15.267 54.790
28.347 1.00 20.63 7 ATOM 1119 CA PHE 136 15.549 53.391 28.150 1.00
20.10 6 ATOM 1120 CB PHE 136 14.343 52.706 27.523 1.00 25.47 6 ATOM
1121 CG PHE 136 14.408 51.250 27.170 1.00 25.61 6 ATOM 1122 CD1 PHE
136 14.528 50.270 28.121 1.00 27.00 6 ATOM 1123 CD2 PHE 136 14.332
50.847 25.841 1.00 27.45 6 ATOM 1124 CE1 PHE 136 14.571 48.929
27.787 1.00 32.62 6 ATOM 1125 CE2 PHE 136 14.385 49.516 25.490 1.00
28.46 6 ATOM 1126 CZ PHE 136 14.493 48.549 26.463 1.00 30.41 6 ATOM
1127 C PHE 136 16.796 53.197 27.297 1.00 24.00 6 ATOM 1128 O PHE
136 16.952 53.801 26.230 1.00 24.50 8 ATOM 1129 N SER 137 17.665
52.294 27.730 1.00 21.97 7 ATOM 1130 CA SER 137 18.914 52.010
27.050 1.00 26.52 6 ATOM 1131 CB SER 137 20.120 52.418 27.908 1.00
30.03 6 ATOM 1132 OG SER 137 20.769 53.559 27.412 1.00 44.19 8 ATOM
1133 C SER 137 19.128 50.507 26.840 1.00 27.38 6 ATOM 1134 O SER
137 18.911 49.694 27.721 1.00 27.33 8 ATOM 1135 N ILE 138 19.654
50.164 25.686 1.00 25.86 7 ATOM 1136 CA ILE 138 20.004 48.806
25.343 1.00 29.46 6 ATOM 1137 CB ILE 138 19.189 48.176 24.193 1.00
33.38 6 ATOM 1138 CG2 ILE 138 19.669 46.748 23.941 1.00 27.23 6
ATOM 1139 CG1 ILE 138 17.679 48.197 24.472 1.00 30.55 6 ATOM 1140
CD1 ILE 138 16.817 48.155 23.223 1.00 29.53 6 ATOM 1141 C ILE 138
21.477 48.875 24.926 1.00 29.88 6 ATOM 1142 O ILE 138 21.768 49.377
23.849 1.00 27.99 8 ATOM 1143 N PRO 139 22.345 48.476 25.837 1.00
31.71 7 ATOM 1144 CD PRO 139 22.018 47.938 27.184 1.00 32.73 6 ATOM
1145 CA PRO 139 23.776 48.398 25.598 1.00 33.85 6 ATOM 1146 CB PRO
139 24.380 48.213 26.983 1.00 36.13 6 ATOM 1147 CG PRO 139 23.248
48.384 27.950 1.00 34.99 6 ATOM 1148 C PRO 139 24.030 47.160 24.741
1.00 35.63 6 ATOM 1149 O PRO 139 23.324 46.160 24.888 1.00 38.22 8
ATOM 1150 N GLN 140 24.974 47.208 23.827 1.00 36.97 7 ATOM 1151 CA
GLN 140 25.288 46.110 22.935 1.00 35.17 6 ATOM 1152 CB GLN 140
26.223 45.124 23.631 1.00 43.87 6 ATOM 1153 CG GLN 140 27.518
45.802 24.088 1.00 49.77 6 ATOM 1154 CD GLN 140 27.883 45.282
25.468 1.00 56.21 6 ATOM 1155 OE1 GLN 140 28.145 44.084 25.593 1.00
57.44 8 ATOM 1156 NE2 GLN 140 27.883 46.161 26.468 1.00 57.25 7
ATOM 1157 C GLN 140 24.060 45.418 22.362 1.00 34.61 6 ATOM 1158 O
GLN 140 23.677 44.284 22.693 1.00 33.34 8 ATOM 1159 N ALA 141
23.473 46.111 21.391 1.00 29.80 7 ATOM 1160 CA ALA 141 22.287
45.634 20.694 1.00 30.02 6 ATOM 1161 CB ALA 141 21.778 46.745
19.774 1.00 27.89 6 ATOM 1162 C ALA 141 22.561 44.400 19.832 1.00
29.52 6 ATOM 1163 O ALA 141 23.650 44.270 19.263 1.00 29.60 8 ATOM
1164 N ASN 142 21.528 43.582 19.665 1.00 30.60 7 ATOM 1165 CA ASN
142 21.642 42.435 18.738 1.00 31.55 6 ATOM 1166 CB ASN 142 21.985
41.139 19.453 1.00 30.39 6 ATOM 1167 CG ASN 142 21.012 40.749
20.534 1.00 31.63 6 ATOM 1168 OD1 ASN 142 19.838 40.423 20.268 1.00
27.57 8 ATOM 1169 ND2 ASN 142 21.479 40.739 21.781 1.00 33.23 7
ATOM 1170 C ASN 142 20.357 42.321 17.936 1.00 32.33 6 ATOM 1171 O
ASN 142 19.453 43.168 18.122 1.00 29.09 8 ATOM 1172 N HIS 143
20.223 41.257 17.134 1.00 29.40 7 ATOM 1173 CA HIS 143 19.075
41.086 16.266 1.00 28.82 6 ATOM 1174 CB HIS 143 19.262 39.895
15.272 1.00 24.51 6 ATOM 1175 CG HIS 143 20.360 40.234 14.295 1.00
31.72 6 ATOM 1176 CD2 HIS 143 20.704 41.420 13.740 1.00 33.88 6
ATOM 1177 ND1 HIS 143 21.278 39.328 13.822 1.00 32.86 7 ATOM 1178
CE1 HIS 143 22.117 39.927 13.008 1.00 31.84 6 ATOM 1179 NE2 HIS 143
21.794 41.202 12.941 1.00 31.48 7 ATOM 1180 C HIS 143 17.747 40.857
16.976 1.00 26.62 6 ATOM 1181 O HIS 143 16.696 41.098 16.366 1.00
25.96 8 ATOM 1182 N SER 144 17.812 40.412 18.221 1.00 20.85 7 ATOM
1183 CA SER 144 16.557 40.128 18.941 1.00 24.82 6 ATOM 1184 CB SER
144 16.839 38.979 19.915 1.00 30.28 6 ATOM 1185 OG SER 144 17.739
39.389 20.930 1.00 39.11 8 ATOM 1186 C SER 144 15.976 41.423 19.474
1.00 24.89 6 ATOM 1187 O SER 144 14.775 41.518 19.755 1.00 25.22 8
ATOM 1188 N HIS 145 16.746 42.522 19.463 1.00 20.33 7 ATOM 1189 CA
HIS 145 16.306 43.861 19.811 1.00 19.38 6 ATOM 1190 CB HIS 145
17.474 44.762 20.302 1.00 19.40 6 ATOM 1191 CG HIS 145 18.145
44.212 21.534 1.00 18.37 6 ATOM 1192 CD2 HIS 145 17.620 43.886
22.744 1.00 18.22 6 ATOM 1193 ND1 HIS 145 19.493 43.965 21.627 1.00
23.55 7 ATOM 1194 CE1 HIS 145 19.768 43.492 22.829 1.00 26.33 6
ATOM 1195 NE2 HIS 145 18.643 43.412 23.525 1.00 21.05 7 ATOM 1196 C
HIS 145 15.589 44.553 18.657 1.00 22.05 6 ATOM 1197 O HIS 145
15.013 45.636 18.848 1.00 21.86 8 ATOM 1198 N SER 146 15.569 43.997
17.440 1.00 20.66 7 ATOM 1199 CA SER 146 14.833 44.649 16.363 1.00
19.96 6 ATOM 1200 CB SER 146 15.075 44.009 14.986 1.00 20.48 6 ATOM
1201 OG SER 146 16.442 44.154 14.613 1.00 25.61 8 ATOM 1202 C SER
146 13.339 44.596 16.656 1.00 20.51 6 ATOM 1203 O SER 146 12.915
43.614 17.287 1.00 22.06 8 ATOM 1204 N GLY 147 12.556 45.578 16.197
1.00 16.70 7 ATOM 1205 CA GLY 147 11.123
45.383 16.411 1.00 20.49 6 ATOM 1206 C GLY 147 10.385 46.714 16.555
1.00 22.63 6 ATOM 1207 O GLY 147 10.982 47.762 16.332 1.00 16.09 8
ATOM 1208 N ASP 148 9.111 46.560 16.951 1.00 20.62 7 ATOM 1209 CA
ASP 148 8.324 47.777 17.121 1.00 21.57 6 ATOM 1210 CB ASP 148 6.882
47.579 16.674 1.00 28.99 6 ATOM 1211 CG ASP 148 6.819 47.144 15.219
1.00 41.07 6 ATOM 1212 OD1 ASP 148 7.849 47.338 14.540 1.00 39.21 8
ATOM 1213 OD2 ASP 148 5.763 46.620 14.808 1.00 39.40 8 ATOM 1214 C
ASP 148 8.315 48.214 18.590 1.00 20.72 6 ATOM 1215 O ASP 148 7.817
47.469 19.447 1.00 20.27 8 ATOM 1216 N TYR 149 8.822 49.440 18.798
1.00 16.97 7 ATOM 1217 CA TYR 149 8.811 49.966 20.164 1.00 18.60 6
ATOM 1218 CB TYR 149 10.193 50.587 20.472 1.00 16.94 6 ATOM 1219 CG
TYR 149 11.272 49.534 20.606 1.00 18.45 6 ATOM 1220 CD1 TYR 149
11.901 48.928 19.528 1.00 19.27 6 ATOM 1221 CE1 TYR 149 12.877
47.948 19.737 1.00 20.18 6 ATOM 1222 CD2 TYR 149 11.672 49.162
21.879 1.00 18.36 6 ATOM 1223 CE2 TYR 149 12.636 48.216 22.116 1.00
15.60 6 ATOM 1224 CZ TYR 149 13.238 47.606 21.027 1.00 18.77 6 ATOM
1225 OH TYR 149 14.211 46.660 21.253 1.00 18.41 8 ATOM 1226 C TYR
149 7.767 51.061 20.355 1.00 15.78 6 ATOM 1227 O TYR 149 7.539
51.859 19.450 1.00 15.86 8 ATOM 1228 N HIS 150 7.196 51.126 21.559
1.00 15.01 7 ATOM 1229 CA HIS 150 6.247 52.171 21.925 1.00 12.99 6
ATOM 1230 CB HIS 150 4.849 51.980 21.372 1.00 11.96 6 ATOM 1231 CG
HIS 150 3.942 51.032 22.117 1.00 17.71 6 ATOM 1232 CD2 HIS 150
2.944 51.295 23.004 1.00 16.09 6 ATOM 1233 ND1 HIS 150 3.988 49.660
21.971 1.00 11.60 7 ATOM 1234 CE1 HIS 150 3.058 49.103 22.716 1.00
16.95 6 ATOM 1235 NE2 HIS 150 2.407 50.057 23.370 1.00 19.22 7 ATOM
1236 C HIS 150 6.263 52.270 23.462 1.00 13.37 6 ATOM 1237 O HIS 150
6.922 51.448 24.129 1.00 12.78 8 ATOM 1238 N CYS 151 5.680 53.355
23.957 1.00 14.21 7 ATOM 1239 CA CYS 151 5.670 53.559 25.414 1.00
15.38 6 ATOM 1240 C CYS 151 4.301 53.982 25.880 1.00 16.27 6 ATOM
1241 O CYS 151 3.422 54.404 25.132 1.00 15.15 8 ATOM 1242 CB CYS
151 6.746 54.562 25.856 1.00 16.85 6 ATOM 1243 SG CYS 151 6.581
56.269 25.248 1.00 14.82 16 ATOM 1244 N THR 152 4.080 53.805 27.186
1.00 17.41 7 ATOM 1245 CA THR 152 2.875 54.223 27.862 1.00 17.27 6
ATOM 1246 CB THR 152 1.899 53.131 28.305 1.00 21.80 6 ATOM 1247 OG1
THR 152 2.527 52.212 29.205 1.00 17.53 8 ATOM 1248 CG2 THR 152
1.356 52.388 27.075 1.00 17.12 6 ATOM 1249 C THR 152 3.346 54.989
29.127 1.00 19.83 6 ATOM 1250 O THR 152 4.471 54.724 29.600 1.00
16.21 8 ATOM 1251 N GLY 153 2.496 55.913 29.534 1.00 17.84 7 ATOM
1252 CA GLY 153 2.815 56.706 30.731 1.00 20.33 6 ATOM 1253 C GLY
153 1.647 57.605 31.108 1.00 18.60 6 ATOM 1254 O GLY 153 0.779
57.915 30.293 1.00 19.87 8 ATOM 1255 N ASN 154 1.603 58.000 32.373
1.00 20.99 7 ATOM 1256 CA ASN 154 0.560 58.815 32.959 1.00 20.36 6
ATOM 1257 CB ASN 154 0.512 58.556 34.478 1.00 26.77 6 ATOM 1258 CG
ASN 154 -0.800 57.928 34.897 1.00 40.91 6 ATOM 1259 OD1 ASN 154
-1.700 58.580 35.441 1.00 46.67 8 ATOM 1260 ND2 ASN 154 -0.927
56.639 34.633 1.00 40.24 7 ATOM 1261 C ASN 154 0.879 60.300 32.817
1.00 22.51 6 ATOM 1262 O ASN 154 1.973 60.685 33.272 1.00 22.15 8
ATOM 1263 N ILE 155 -0.018 61.067 32.202 1.00 19.40 7 ATOM 1264 CA
ILE 155 0.198 62.514 32.139 1.00 22.27 6 ATOM 1265 CB ILE 155 0.210
63.116 30.731 1.00 26.29 6 ATOM 1266 CG2 ILE 155 0.327 64.640
30.831 1.00 23.31 6 ATOM 1267 CG1 ILE 155 1.367 62.544 29.899 1.00
28.16 6 ATOM 1268 CD1 ILE 155 1.371 62.874 28.434 1.00 29.42 6 ATOM
1269 C ILE 155 -0.974 63.089 32.941 1.00 27.67 6 ATOM 1270 O ILE
155 -2.112 62.726 32.639 1.00 24.10 8 ATOM 1271 N GLY 156 -0.732
63.838 34.020 1.00 33.10 7 ATOM 1272 CA GLY 156 -1.942 64.285
34.780 1.00 37.62 6 ATOM 1273 C GLY 156 -2.447 63.053 35.527 1.00
38.80 6 ATOM 1274 O GLY 156 -1.659 62.512 36.299 1.00 43.91 8 ATOM
1275 N TYR 157 -3.655 62.573 35.307 1.00 41.47 7 ATOM 1276 CA TYR
157 -4.182 61.357 35.894 1.00 43.65 6 ATOM 1277 CB TYR 157 -5.381
61.642 36.832 1.00 51.51 6 ATOM 1278 CG TYR 157 -5.020 62.592
37.961 1.00 57.42 6 ATOM 1279 CD1 TYR 157 -5.523 63.885 37.982 1.00
60.45 6 ATOM 1280 CE1 TYR 157 -5.179 64.765 38.992 1.00 62.57 6
ATOM 1281 CD2 TYR 157 -4.140 62.204 38.963 1.00 61.00 6 ATOM 1282
CE2 TYR 157 -3.788 63.079 39.982 1.00 63.03 6 ATOM 1283 CZ TYR 157
-4.313 64.353 39.986 1.00 63.56 6 ATOM 1284 OH TYR 157 -3.979
65.237 40.984 1.00 66.68 8 ATOM 1285 C TYR 157 -4.676 60.351 34.849
1.00 41.96 6 ATOM 1286 O TYR 157 -5.445 59.420 35.115 1.00 41.33 8
ATOM 1287 N THR 158 -4.298 60.547 33.594 1.00 36.77 7 ATOM 1288 CA
THR 158 -4.722 59.693 32.496 1.00 30.71 6 ATOM 1289 CB THR 158
-5.260 60.597 31.364 1.00 30.82 6 ATOM 1290 OG1 THR 158 -6.237
61.471 31.942 1.00 30.47 8 ATOM 1291 CG2 THR 158 -5.851 59.819
30.207 1.00 29.21 6 ATOM 1292 C THR 158 -3.532 58.944 31.912 1.00
25.66 6 ATOM 1293 O THR 158 -2.521 59.609 31.642 1.00 24.50 8 ATOM
1294 N LEU 159 -3.689 57.664 31.609 1.00 21.00 7 ATOM 1295 CA LEU
159 -2.617 56.924 30.960 1.00 21.01 6 ATOM 1296 CB LEU 159 -2.737
55.435 31.284 1.00 26.53 6 ATOM 1297 CG LEU 159 -1.601 54.487
30.958 1.00 27.15 6 ATOM 1298 CD1 LEU 159 -0.323 54.817 31.713 1.00
25.15 6 ATOM 1299 CD2 LEU 159 -1.979 53.036 31.316 1.00 28.75 6
ATOM 1300 C LEU 159 -2.654 57.179 29.461 1.00 22.04 6 ATOM 1301 O
LEU 159 -3.711 57.248 28.844 1.00 22.64 7 ATOM 1302 N PHE 160
-1.484 57.396 28.855 1.00 20.79 7 ATOM 1303 CA PHE 160 -1.430
57.576 27.409 1.00 19.10 6 ATOM 1304 CB PHE 160 -0.821 58.946
27.060 1.00 20.91 6 ATOM 1305 CG PHE 160 -1.848 60.034 27.216 1.00
19.50 6 ATOM 1306 CD1 PHE 160 -1.971 60.676 28.442 1.00 24.86 6
ATOM 1307 CD2 PHE 160 -2.645 60.409 26.156 1.00 21.03 6 ATOM 1308
CE1 PHE 160 -2.903 61.709 28.588 1.00 29.44 6 ATOM 1309 CE2 PHE 160
-3.582 61.421 26.296 1.00 19.89 6 ATOM 1310 CZ PHE 160 -3.704
62.074 27.529 1.00 25.34 6 ATOM 1311 C PHE 160 -0.521 56.513 26.794
1.00 17.36 6 ATOM 1312 O PHE 160 0.346 55.982 27.504 1.00 18.36 8
ATOM 1313 N SER 161 -0.753 56.240 25.521 1.00 17.60 7 ATOM 1314 CA
SER 161 0.087 55.302 24.785 1.00 14.63 6 ATOM 1315 CB SER 161
-0.744 54.150 24.188 1.00 20.14 6 ATOM 1316 OG SER 161 0.115 53.054
23.901 1.00 21.55 8 ATOM 1317 C SER 161 0.662 56.037 23.561 1.00
18.96 6 ATOM 1318 O SER 161 -0.101 56.753 22.894 1.00 19.79 8 ATOM
1319 N SER 162 1.921 55.796 23.232 1.00 16.19 7 ATOM 1320 CA SER
162 2.518 56.404 22.049 1.00 16.74 6 ATOM 1321 CB SER 162 4.029
56.678 22.233 1.00 16.78 6 ATOM 1322 OG SER 162 4.801 55.530 21.900
1.00 21.00 8 ATOM 1323 C SER 162 2.322 55.485 20.845 1.00 18.24 6
ATOM 1324 O SER 162 1.949 54.305 20.987 1.00 16.85 8 ATOM 1325 N
LYS 163 2.535 56.027 19.652 1.00 17.96 7 ATOM 1326 CA LYS 163 2.484
55.203 18.445 1.00 17.36 6 ATOM 1327 CB LYS 163 2.369 55.957 17.133
1.00 20.94 6 ATOM 1328 CG LYS 163 1.228 56.885 16.902 1.00 25.34 6
ATOM 1329 CD LYS 163 -0.128 56.271 16.685 1.00 29.02 6 ATOM 1330 CE
LYS 163 -0.954 57.131 15.721 1.00 42.35 6 ATOM 1331 NZ LYS 163
-0.495 58.558 15.692 1.00 38.14 7 ATOM 1332 C LYS 163 3.821 54.466
18.391 1.00 17.27 6 ATOM 1333 O LYS 163 4.817 54.906 18.978 1.00
16.54 8 ATOM 1334 N PRO 164 3.840 53.348 17.696 1.00 18.39 7 ATOM
1335 CD PRO 164 2.702 52.743 16.952 1.00 20.79 6 ATOM 1336 CA PRO
164 5.060 52.572 17.546 1.00 19.84 6 ATOM 1337 CB PRO 164 4.545
51.177 17.142 1.00 17.33 6 ATOM 1338 CG PRO 164 3.254 51.416 16.475
1.00 21.76 6 ATOM 1339 C PRO 164 6.032 53.169 16.528 1.00 19.62 6
ATOM 1340 O PRO 164 5.723 53.942 15.619 1.00 19.46 8 ATOM 1341 N
VAL 165 7.295 52.833 16.674 1.00 17.22 7 ATOM 1342 CA VAL 165 8.427
53.162 15.841 1.00 20.36 6 ATOM 1343 CB VAL 165 9.405 54.190 16.450
1.00 20.84 6 ATOM 1344 CG1 VAL 165 10.418 54.643 15.404 1.00 20.46
6 ATOM 1345 CG2 VAL 165 8.699 55.475 16.899 1.00 23.72 6 ATOM 1346
C VAL 165 9.173 51.833 15.590 1.00 22.05 6 ATOM 1347 O VAL 165
9.532 51.094 16.499 1.00 22.10 8 ATOM 1348 N THR 166 9.444 51.549
14.320 1.00 24.93 7 ATOM 1349 CA THR 166 10.111 50.317 13.939 1.00
26.07 6 ATOM 1350 CB THR 166 9.631 49.784 12.579 1.00 31.66 6 ATOM
1351 OG1 THR 166 9.737 50.811 11.569 1.00 38.39 8 ATOM 1352 CG2 THR
166 8.180 49.353 12.694 1.00 23.71 6 ATOM 1353 C THR 166 11.611
50.597 13.909 1.00 25.06 6 ATOM 1354 O THR 166 11.985 51.536 13.244
1.00 21.88 8 ATOM 1355 N ILE 167 12.362 49.878 14.714 1.00 21.40 7
ATOM 1356 CA ILE 167 13.784 49.907 14.909 1.00 25.06 6 ATOM 1357 CB
ILE 167 14.088 50.164 16.424 1.00 26.21 6 ATOM 1358 CG2 ILE 167
15.588 50.159 16.673 1.00 26.68 6 ATOM 1359 CG1 ILE 167 13.415
51.472 16.825 1.00 26.56 6 ATOM 1360 CD1 ILE 167 13.946 52.318
17.939 1.00 30.83 6 ATOM 1361 C ILE 167 14.416 48.572 14.501 1.00
24.36 6 ATOM 1362 O ILE 167 14.013 47.482 14.920 1.00 23.36 8 ATOM
1363 N THR 168 15.412 48.591 13.630 1.00 22.83 7 ATOM 1364 CA THR
168 16.083 47.405 13.152 1.00 27.27 6 ATOM 1365 CB THR 168 15.945
47.266 11.622 1.00 31.88 6 ATOM 1366 OG1 THR 168 14.565 47.371
11.277 1.00 32.11 8 ATOM 1367 CG2 THR 168 16.462 45.894 11.179 1.00
34.54 6 ATOM 1368 C THR 168 17.575 47.414 13.501 1.00 28.53 6 ATOM
1369 O THR 168 18.190 48.483 13.508 1.00 32.64 8 ATOM 1370 N VAL
169 18.090 46.260 13.863 1.00 23.55 7 ATOM 1371 CA VAL 169 19.472
46.011 14.163 1.00 27.27 6 ATOM 1372 CB VAL 169 19.728 45.359
15.523 1.00 28.51 6 ATOM 1373 CG1 VAL 169 21.227 45.133 15.757 1.00
26.42 6 ATOM 1374 CG2 VAL 169 19.189 46.160 16.696 1.00 27.97 6
ATOM 1375 C VAL 169 20.011 45.022 13.098 1.00 32.65 6 ATOM 1376 O
VAL 169 19.332 44.056 12.710 1.00 33.21 8 ATOM 1377 N GLN 170
21.245 45.196 12.689 0.01 33.85 7 ATOM 1378 CA GLN 170 21.966
44.390 11.737 0.01 35.75 6 ATOM 1379 CB GLN 170 23.335 44.027
12.362 0.01 36.48 6 ATOM 1380 CG GLN 170 24.465 44.012 11.347 0.01
37.54 6 ATOM 1381 CD GLN 170 25.478 45.110 11.599 0.01 37.91 6 ATOM
1382 OE1 GLN 170 25.142 46.186 12.096 0.01 38.17 8 ATOM 1383 NE2
GLN 170 26.735 44.846 11.257 0.01 38.21 7 ATOM 1384 C GLN 170
21.355 43.088 11.241 0.01 36.70 6 ATOM 1385 O GLN 170 21.049 42.167
11.995 0.01 36.81 8 ATOM 1386 N VAL 171 21.273 42.959 9.919 0.01
37.51 7 ATOM 1387 CA VAL 171 20.781 41.772 9.240 0.01 38.20 6 ATOM
1388 CB VAL 171 19.483 41.208 9.842 0.01 38.61 6 ATOM 1389 CG1 VAL
171 18.334 42.199 9.681 0.01 38.88 6 ATOM 1390 CG2 VAL 171 19.115
39.881 9.180 0.01 38.83 6 ATOM 1391 C VAL 171 20.587 42.048 7.750
0.01 38.42 6 ATOM 1392 O VAL 171 21.420 41.573 6.949 0.01 38.53 8
ATOM 1393 OW0 WAT 201 13.958 68.106 19.930 1.00 18.36 8 ATOM 1394
OW0 WAT 202 13.653 41.241 23.320 1.00 24.59 8 ATOM 1395 OW0 WAT 203
5.895 57.410 18.965 1.00 14.14 8 ATOM 1396 OW0 WAT 204 9.519 72.688
30.514 1.00 42.11 8 ATOM 1397 OW0 WAT 205 8.700 64.454 28.355 1.00
21.65 8 ATOM 1398 OW0 WAT 206 25.548 65.664 7.898 1.00 24.88 8 ATOM
1399 OW0 WAT 207 2.902 52.471 31.897 1.00 19.13 8 ATOM 1400 OW0 WAT
208 14.303 45.256 23.676 1.00 24.28 8 ATOM 1401 OW0 WAT 209 10.371
62.552 29.076 1.00 27.73 8 ATOM 1402 OW0 WAT 210 12.433 66.629
21.505 1.00 14.04 8 ATOM 1403 OW0 WAT 211 5.417 47.499 21.002 1.00
16.89 8 ATOM 1404 OW0 WAT 212 29.599 82.797 11.595 1.00 34.62 8
ATOM 1405 OW0 WAT 213 17.813 70.187 2.648 1.00 16.34 8 ATOM 1406
OW0 WAT 214 6.656 58.315 16.413 1.00 24.31 8 ATOM 1407 OW0 WAT 215
21.191 80.146 5.335 1.00 30.05 8 ATOM 1408 OW0 WAT 216 15.621
66.766 18.319 1.00 18.82 8 ATOM 1409 OW0 WAT 217 6.528 56.410
14.460 1.00 26.68 8 ATOM 1410 OW0 WAT 218 6.213 69.723 22.792 1.00
19.89 8 ATOM 1411 OW0 WAT 219 12.935 67.874 24.109 1.00 29.95 8
ATOM 1412 OW0 WAT 220 -2.277 62.236 20.953 1.00 28.34 8 ATOM 1413
OW0 WAT 221 20.151 71.344 0.183 1.00 21.62 8 ATOM 1414 OW0 WAT 222
27.773 65.203 6.295 1.00 20.74 8 ATOM 1415 OW0 WAT 223 -0.481
58.864 19.811 1.00 24.67 8 ATOM 1416 OW0 WAT 224 17.815 67.914
1.120 1.00 26.99 8 ATOM 1417 OW0 WAT 225 16.604 64.761 25.523. 1.00
18.45 8 ATOM 1418 OW0 WAT 226 -0.330 59.580 22.516 1.00 29.01 8
ATOM 1419 OW0 WAT 227 13.324 40.955 17.129 1.00 40.98 8 ATOM 1420
OW0 WAT 228 9.214 41.380 22.450 1.00 41.91 8 ATOM 1421 OW0 WAT 229
20.146 82.270 13.850 1.00 50.03 8 ATOM 1422 OW0 WAT 230 21.707
80.353 12.325 1.00 18.46 8 ATOM 1423 OW0 WAT 231 15.403 67.167
25.599 1.00 21.44 8 ATOM 1424 OW0 WAT 232 12.703 63.258 30.174 1.00
37.28 8 ATOM 1425 OW0 WAT 233 12.479 61.400 39.250 1.00 23.78 8
ATOM 1426 OW0 WAT 234 13.921 59.460 9.106 1.00 40.49 8 ATOM 1427
OW0 WAT 235 7.230 72.381 24.432 1.00 41.81 8 ATOM 1428 OW0 WAT 236
2.989 58.681 19.344 1.00 17.29 8 ATOM 1429 OW0 WAT 237 12.865
75.036 10.180 1.00 47.19 8 ATOM 1430 OW0 WAT 238 2.754 67.991
13.259 1.00 35.75 8 ATOM 1431 OW0 WAT 239 17.416 57.608 26.641 1.00
32.09 8 ATOM 1432 OW0 WAT 240 31.068 75.579 10.888 1.00 20.85 8
ATOM 1433 OW0 WAT 241 17.725 71.985 21.261 1.00 25.43 8 ATOM 1434
OW0 WAT 242 32.760 65.251 6.079 1.00 38.04 8 ATOM 1435 OW0 WAT 243
14.079 72.373 25.218 1.00 20.23 8 ATOM 1436 OW0 WAT 244 16.644
77.936 -2.315 1.00 34.00 8 ATOM 1437 OW0 WAT 245 1.790 62.643
35.518 1.00 30.63 8 ATOM 1438 OW0 WAT 246 10.026 76.840 13.639 1.00
31.10 8 ATOM 1439 OW0 WAT 247 11.096 40.538 24.599 1.00 33.25 8
ATOM 1440 OW0 WAT 248 19.457 73.016 -2.970 1.00 36.88 8 ATOM 1441
OW0 WAT 249 18.578 60.108 26.756 1.00 30.86 8 ATOM 1442 OW0 WAT 250
11.119 78.675 16.190 1.00 37.83 8 ATOM 1443 OW0 WAT 251 2.583
76.687 28.032 1.00 73.18 8 ATOM 1444 OW0 WAT 252 0.243 75.153
22.803 1.00 34.15 8 ATOM 1445 OW0 WAT 253 33.328 82.165 10.255 1.00
23.17 8 ATOM 1446 OW0 WAT 254 22.212 87.081 5.080 1.00 51.41 8 ATOM
1447 OW0 WAT 255 21.393 83.921 11.680 1.00 31.47 8 ATOM 1448 OW0
WAT 256 37.174 72.382 4.349 1.00 36.66 8 ATOM 1449 OW0 WAT 257
23.291 53.950 13.981 1.00 45.02 8 ATOM 1450 OW0 WAT 258 31.521
80.134 5.404 1.00 28.19 8 ATOM 1451 OW0 WAT 259 11.904 78.169 8.209
1.00 61.39 8 ATOM 1452 OW0 WAT 260 7.393 36.160 24.668 1.00 45.96 8
ATOM 1453 OW0 WAT 261 12.356 70.954 23.727 1.00 23.77 8 ATOM 1454
OW0 WAT 262 33.898 69.078 7.353 1.00 32.96 8 ATOM 1455 OW0 WAT 263
28.502 52.764 25.478 1.00 58.40 8 ATOM 1456 OW0 WAT 264 23.414
37.810 18.427 1.00 35.16 8 ATOM 1457 OW0 WAT 265 4.792 74.631
16.778 1.00 44.49 8 ATOM 1458 OW0 WAT 266 28.509 77.721 -1.620 1.00
50.51 8 ATOM 1459 OW0 WAT 267 19.685 68.488 -0.712 1.00 45.74 8
ATOM 1460 OW0 WAT 268 10.899 74.487 23.620 1.00 43.61 8 ATOM 1461
OW0 WAT 269 -1.033 73.720 20.128 1.00 34.52 8 ATOM 1462 OW0 WAT 270
15.215 67.397 0.077 1.00 27.35 8 ATOM 1463 OW0 WAT 271 8.748 79.989
16.508 1.00 51.59 8 ATOM 1464 OW0 WAT 272 22.332 82.314 3.707 1.00
30.25 8 ATOM 1465 OW0 WAT 273 23.373 70.771 17.610 1.00 22.44 8
ATOM 1466 OW0 WAT 274 11.965 67.872 26.359 1.00 26.92 8 ATOM 1467
OW0 WAT 275 35.793 71.146 7.198 1.00 27.19 8 ATOM 1468 OW0 WAT 276
10.333 72.530 25.867 1.00 46.78 8 ATOM 1469 OW0 WAT 277 17.230
69.185 24.852 1.00 26.22 8 ATOM 1470 OW0 WAT 278 17.594 51.432
30.830 1.00 32.58 8 ATOM 1471 OW0 WAT 279 8.561 67.703 32.884 1.00
37.04 8 ATOM 1472 OW0 WAT 280 16.374 71.765 -4.195 1.00 31.45 8
ATOM 1473 OW0 WAT 281 8.995 70.329 24.946 1.00 36.64 8 ATOM 1474
OW0 WAT 282 19.019 47.051 28.676 1.00 48.06 8 ATOM 1475 OW0 WAT 283
20.039 61.350 15.742 1.00 23.23 8 ATOM 1476 OW0 WAT 284 21.308
55.309 20.658 1.00 28.24 8 ATOM 1477 OW0 WAT 285 7.405 70.019 5.261
1.00 41.47 8 ATOM 1478 OW0 WAT 286 23.729 66.066 0.632 1.00 30.27 8
ATOM 1479 OW0 WAT 287 15.826 40.095 23.946 1.00 41.94 8 ATOM 1480
OW0 WAT 288 -0.119 50.371 24.812 0.50 25.93 8 ATOM 1481 OW0 WAT 289
3.397 54.879 42.245 1.00 29.87 8 ATOM 1482 OW0 WAT 290 10.215
53.151 32.270 1.00 43.33 8 ATOM 1483 OW0 WAT 291 8.440 65.109
33.883 1.00 34.09 8 END
[0143]
2TABLE 2 REMARK Written by O version 5.10.1 REMARK Wed May 20
10:23:51 1998 CRYST1 79.221 100.866 28.172 90.00 90.00 90.00 ORIGX1
1.000000 0.000000 0.000000 0.00000 ORIGX2 0.000000 1.000000
0.000000 0.00000 ORIGX3 0.000000 0.000000 1.000000 0.00000 SCALE1
0.012623 0.000000 0.000000 0.00000 SCALE2 0.000000 0.009914
0.000000 0.00000 SCALE3 0.000000 0.000000 0.035496 0.00000 ATOM 1
CB ALA 1 36.645 68.826 -4.702 1.00 51.37 6 ATOM 2 C ALA 1 36.199
68.294 -2.285 1.00 42.22 6 ATOM 3 O ALA 1 36.801 67.492 -1.569 1.00
42.70 8 ATOM 4 N ALA 1 34.367 68.121 -3.997 1.00 45.74 7 ATOM 5 CA
ALA 1 35.829 67.992 -3.724 1.00 43.68 6 ATOM 6 N PRO 2 35.903
69.499 -1.817 1.00 40.54 7 ATOM 7 CD PRO 2 35.149 70.546 -2.533
1.00 38.91 6 ATOM 8 CA PRO 2 36.172 69.844 -0.425 1.00 38.61 6 ATOM
9 CB PRO 2 35.765 71.300 -0.322 1.00 39.86 6 ATOM 10 CG PRO 2
34.790 71.513 -1.426 1.00 41.36 6 ATOM 11 C PRO 2 35.294 68.931
0.434 1.00 36.70 6 ATOM 12 O PRO 2 34.188 68.654 -0.042 1.00 32.46
8 ATOM 13 N PRO 3 35.789 68.496 1.579 1.00 33.82 7 ATOM 14 CD PRO 3
37.120 68.857 2.110 1.00 35.16 6 ATOM 15 CA PRO 3 35.069 67.637
2.491 1.00 38.25 6 ATOM 16 CB PRO 3 35.872 67.639 3.799 1.00 37.39
6 ATOM 17 CG PRO 3 37.180 68.267 3.486 1.00 37.41 6 ATOM 18 C PRO 3
33.653 68.136 2.790 1.00 37.48 6 ATOM 19 O PRO 3 33.393 69.335
2.683 1.00 34.39 8 ATOM 20 N LYS 4 32.763 67.212 3.173 1.00 37.04 7
ATOM 21 CA LYS 4 31.399 67.678 3.424 1.00 34.97 6 ATOM 22 CB LYS 4
30.318 66.664 3.122 1.00 43.98 6 ATOM 23 CG LYS 4 30.564 65.191
3.278 1.00 47.64 6 ATOM 24 CD LYS 4 29.775 64.349 2.292 1.00 52.03
6 ATOM 25 CE LYS 4 28.317 64.743 2.137 1.00 57.56 6 ATOM 26 NZ LYS
4 27.724 64.253 0.855 1.00 56.40 7 ATOM 27 C LYS 4 31.243 68.234
4.825 1.00 31.44 6 ATOM 28 O LYS 4 31.846 67.769 5.784 1.00 29.91 8
ATOM 29 N ALA 5 30.416 69.280 4.908 1.00 28.75 7 ATOM 30 CA ALA 5
30.039 69.813 6.218 1.00 27.21 6 ATOM 31 CB ALA 5 29.155 71.032
6.110 1.00 21.94 6 ATOM 32 C ALA 5 29.278 68.683 6.923 1.00 26.42 6
ATOM 33 O ALA 5 28.760 67.794 6.222 1.00 26.10 8 ATOM 34 N VAL 6
29.231 68.674 8.241 1.00 24.91 7 ATOM 35 CA VAL 6 28.515 67.632
8.985 1.00 26.95 6 ATOM 36 CB VAL 6 29.490 66.738 9.770 1.00 29.36
6 ATOM 37 CG1 VAL 6 28.779 65.726 10.676 1.00 29.86 6 ATOM 38 CG2
VAL 6 30.434 66.024 8.801 1.00 26.74 6 ATOM 39 C VAL 6 27.503
68.253 9.942 1.00 28.93 6 ATOM 40 O VAL 6 27.846 68.994 10.866 1.00
31.46 8 ATOM 41 N LEU 7 26.233 67.929 9.758 1.00 30.08 7 ATOM 42 CA
LEU 7 25.105 68.383 10.546 1.00 29.33 6 ATOM 43 CB LEU 7 23.839
68.346 9.657 1.00 33.18 6 ATOM 44 CG LEU 7 22.828 69.458 9.960 1.00
34.94 6 ATOM 45 CD1 LEU 7 22.082 69.876 8.721 1.00 27.55 6 ATOM 46
CD2 LEU 7 21.887 69.002 11.069 1.00 32.30 6 ATOM 47 C LEU 7 24.816
67.565 11.794 1.00 29.57 6 ATOM 48 O LEU 7 24.653 66.351 11.800
1.00 30.04 8 ATOM 49 N LYS 8 24.768 68.242 12.930 1.00 28.04 7 ATOM
50 CA LYS 8 24.568 67.692 14.257 1.00 25.12 6 ATOM 51 CB LYS 8
25.738 68.179 15.132 1.00 33.32 6 ATOM 52 CG LYS 8 25.777 67.611
16.532 1.00 39.37 6 ATOM 53 CD LYS 8 25.967 68.598 17.652 1.00
43.84 6 ATOM 54 CE LYS 8 27.129 69.561 17.487 1.00 47.78 6 ATOM 55
NZ LYS 8 27.525 70.175 18.793 1.00 48.98 7 ATOM 56 C LYS 8 23.233
68.192 14.797 1.00 24.53 6 ATOM 57 O LYS 8 22.934 69.384 14.739
1.00 25.35 8 ATOM 58 N LEU 9 22.423 67.310 15.333 1.00 24.78 7 ATOM
59 CA LEU 9 21.080 67.553 15.843 1.00 22.07 6 ATOM 60 CB LEU 9
20.189 66.483 15.190 1.00 20.04 6 ATOM 61 CG LEU 9 18.725 66.363
15.596 1.00 20.57 6 ATOM 62 CD1 LEU 9 17.980 67.624 15.214 1.00
19.57 6 ATOM 63 CD2 LEU 9 18.084 65.137 14.903 1.00 23.44 6 ATOM 64
C LEU 9 21.019 67.415 17.346 1.00 21.01 6 ATOM 65 O LEU 9 21.424
66.393 17.869 1.00 22.38 8 ATOM 66 N GLU 10 20.583 68.410 18.118
1.00 22.53 7 ATOM 67 CA GLU 10 20.480 68.285 19.567 1.00 21.02 6
ATOM 68 CB GLU 10 21.523 69.182 20.270 1.00 27.36 6 ATOM 69 CGA GLU
10 22.971 68.778 20.090 0.50 28.21 6 ATOM 70 CGB GLU 10 22.946
68.657 20.195 0.50 38.29 6 ATOM 71 CDA GLU 10 24.047 69.789 20.422
0.50 28.55 6 ATOM 72 CDB GLU 10 23.100 67.202 20.587 0.50 43.48 6
ATOM 73 OE1 GLU 10 25.131 69.365 20.907 0.50 26.56 8 ATOM 74 OE1
GLU 10 22.443 66.771 21.565 0.50 47.24 8 ATOM 75 OE2 GLU 10 23.888
71.008 20.186 0.50 22.10 8 ATOM 76 OE2 GLU 10 23.871 66.486 19.908
0.50 46.42 8 ATOM 77 C GLU 10 19.096 68.728 20.008 1.00 19.76 6
ATOM 78 O GLU 10 18.701 69.842 19.613 1.00 18.00 8 ATOM 79 N PRO 11
18.423 67.995 20.888 1.00 19.07 7 ATOM 80 CD PRO 11 17.058 68.340
21.390 1.00 18.71 6 ATOM 81 CA PRO 11 18.834 66.662 21.319 1.00
18.84 6 ATOM 82 CB PRO 11 17.807 66.272 22.365 1.00 17.38 6 ATOM 83
CG PRO 11 16.560 67.000 21.944 1.00 18.86 6 ATOM 84 C PRO 11 18.787
65.758 20.090 1.00 20.01 6 ATOM 85 O PRO 11 18.310 66.212 19.051
1.00 16.22 8 ATOM 86 N PRO 12 19.232 64.517 20.155 1.00 19.94 7
ATOM 87 CD PRO 12 19.915 63.948 21.361 1.00 21.08 6 ATOM 88 CA PRO
12 19.409 63.700 18.976 1.00 20.68 6 ATOM 89 CB PRO 12 20.455
62.656 19.397 1.00 19.82 6 ATOM 90 CG PRO 12 20.292 62.567 20.872
1.00 23.59 6 ATOM 91 C PRO 12 18.179 63.061 18.395 1.00 18.70 6
ATOM 92 O PRO 12 18.268 62.475 17.318 1.00 19.85 8 ATOM 93 N TRP 13
17.039 63.169 19.059 1.00 15.64 7 ATOM 94 CA TRP 13 15.815 62.568
18.561 1.00 17.91 6 ATOM 95 CB TRP 13 14.688 62.840 19.562 1.00
14.32 6 ATOM 96 CG TRP 13 15.124 62.749 21.006 1.00 16.77 6 ATOM 97
CD2 TRP 13 15.633 61.612 21.703 1.00 16.90 6 ATOM 98 CE2 TRP 13
15.899 62.005 23.032 1.00 16.87 6 ATOM 99 CE3 TRP 13 15.867 60.279
21.350 1.00 18.03 6 ATOM 100 CD1 TRP 13 15.106 63.769 21.916 1.00
18.97 6 ATOM 101 NE1 TRP 13 15.589 63.343 23.137 1.00 11.16 7 ATOM
102 CZ2 TRP 13 16.405 61.124 23.973 1.00 15.92 6 ATOM 103 CZ3 TRP
13 16.358 59.409 22.301 1.00 10.59 6 ATOM 104 CH2 TRP 13 16.645
59.825 23.611 1.00 17.87 6 ATOM 105 C TRP 13 15.421 63.033 17.163
1.00 19.47 6 ATOM 106 O TRP 13 15.283 64.238 16.908 1.00 17.22 8
ATOM 107 N ILE 14 15.101 62.078 16.275 1.00 16.57 7 ATOM 108 CA ILE
14 14.666 62.441 14.936 1.00 18.93 6 ATOM 109 CB ILE 14 15.185
61.523 13.816 1.00 16.07 6 ATOM 110 CG2 ILE 14 16.720 61.521 13.840
1.00 16.61 6 ATOM 111 CG1 ILE 14 14.582 60.119 13.972 1.00 21.35 6
ATOM 112 CD1 ILE 14 15.045 59.150 12.896 1.00 26.28 6 ATOM 113 C
ILE 14 13.144 62.549 14.825 1.00 20.48 6 ATOM 114 O ILE 14 12.652
63.048 13.817 1.00 19.41 8 ATOM 115 N ASN 15 12.403 62.087 15.836
1.00 19.46 7 ATOM 116 CA ASN 15 10.935 62.270 15.778 1.00 18.11 6
ATOM 117 CB ASN 15 10.161 60.962 15.731 1.00 13.53 6 ATOM 118 CG
ASN 15 10.591 59.946 16.762 1.00 19.11 6 ATOM 119 OD1 ASN 15 11.728
59.959 17.227 1.00 13.35 8 ATOM 120 ND2 ASN 15 9.688 59.033 17.142
1.00 10.11 7 ATOM 121 C ASN 15 10.632 63.124 17.005 1.00 17.54 6
ATOM 122 O ASN 15 11.016 62.735 18.111 1.00 15.32 8 ATOM 123 N VAL
16 10.122 64.331 16.805 1.00 16.86 7 ATOM 124 CA VAL 16 9.871
65.273 17.893 1.00 15.77 6 ATOM 125 CB VAL 16 10.761 66.534 17.748
1.00 16.54 6 ATOM 126 CG1 VAL 16 12.251 66.141 17.733 1.00 13.42 6
ATOM 127 CG2 VAL 16 10.490 67.345 16.491 1.00 18.04 6 ATOM 128 C
VAL 16 8.420 65.708 17.921 1.00 19.01 6 ATOM 129 O VAL 16 7.618
65.381 17.010 1.00 17.12 8 ATOM 130 N LEU 17 8.022 66.422 18.964
1.00 17.68 7 ATOM 131 CA LEU 17 6.664 66.962 19.068 1.00 15.11 6
ATOM 132 CB LEU 17 6.162 66.726 20.522 1.00 20.26 6 ATOM 133 CG LEU
17 5.873 65.251 20.823 1.00 23.07 6 ATOM 134 CD1 LEU 17 5.447
65.013 22.253 1.00 17.70 6 ATOM 135 CD2 LEU 17 4.832 64.714 19.855
1.00 26.74 6 ATOM 136 C LEU 17 6.563 68.439 18.732 1.00 16.37 6
ATOM 137 O LEU 17 7.518 69.187 18.961 1.00 18.24 8 ATOM 138 N GLN
18 5.424 68.931 18.227 1.00 18.55 7 ATOM 139 CA GLN 18 5.237 70.370
18.032 1.00 19.13 6 ATOM 140 CB GLN 18 3.790 70.721 17.696 1.00
31.65 6 ATOM 141 CG GLN 18 3.510 71.249 16.314 1.00 37.32 6 ATOM
142 CD GLN 18 2.120 70.902 15.800 1.00 36.92 6 ATOM 143 OE1 GLN 18
1.953 70.032 14.943 1.00 30.97 8 ATOM 144 NE2 GLN 18 1.135 71.618
16.333 1.00 31.73 7 ATOM 145 C GLN 18 5.561 71.077 19.348 1.00
19.43 6 ATOM 146 O GLN 18 5.194 70.568 20.413 1.00 18.10 8 ATOM 147
N GLU 19 6.317 72.164 19.232 1.00 19.68 7 ATOM 148 CA GLU 19 6.727
73.045 20.293 1.00 18.88 6 ATOM 149 CB GLU 19 5.597 73.341 21.293
1.00 27.39 6 ATOM 150 CG GLU 19 4.649 74.418 20.714 1.00 30.12 6
ATOM 151 CD GLU 19 3.558 74.699 21.720 1.00 41.87 6 ATOM 152 OE1
GLU 19 3.857 75.330 22.758 1.00 48.83 8 ATOM 153 OE2 GLU 19 2.421
74.272 21.464 1.00 46.61 8 ATOM 154 C GLU 19 8.004 72.622 20.998
1.00 21.46 6 ATOM 155 O GLU 19 8.496 73.405 21.815 1.00 26.39 8
ATOM 156 N ASP 20 8.606 71.506 20.619 1.00 19.91 7 ATOM 157 CA ASP
20 9.898 71.094 21.114 1.00 20.76 6 ATOM 158 CB ASP 20 10.285
69.649 20.726 1.00 13.47 6 ATOM 159 CG ASP 20 9.587 68.578 21.526
1.00 13.93 6 ATOM 160 OD1 ASP 20 8.873 68.805 22.534 1.00 17.57 8
ATOM 161 OD2 ASP 20 9.723 67.405 21.104 1.00 13.79 8 ATOM 162 C ASP
20 11.002 71.950 20.451 1.00 19.58 6 ATOM 163 O ASP 20 10.913
72.219 19.262 1.00 17.49 8 ATOM 164 N SER 21 12.071 72.198 21.174
1.00 17.22 7 ATOM 165 CA SER 21 13.233 72.929 20.659 1.00 17.62 6
ATOM 166 CBA SER 21 14.011 73.525 21.844 0.50 17.49 6 ATOM 167 CBB
SER 21 13.981 73.556 21.846 0.50 13.14 6 ATOM 168 OGA SER 21 14.900
74.516 21.355 0.50 22.95 8 ATOM 169 OGB SER 21 13.175 74.579 22.416
0.50 6.85 8 ATOM 170 C SER 21 14.181 72.038 19.873 1.00 18.61 6
ATOM 171 O SER 21 14.424 70.884 20.265 1.00 21.41 8 ATOM 172 N VAL
22 14.638 72.512 18.721 1.00 15.80 7 ATOM 173 CA VAL 22 15.585
71.733 17.910 1.00 17.93 6 ATOM 174 CB VAL 22 15.052 71.234 16.560
1.00 20.37 6 ATOM 175 CG1 VAL 22 16.093 70.401 15.804 1.00 17.77 6
ATOM 176 CG2 VAL 22 13.858 70.300 16.679 1.00 17.26 6 ATOM 177 C
VAL 22 16.822 72.609 17.665 1.00 19.20 6 ATOM 178 O VAL 22 16.633
73.769 17.291 1.00 18.52 8 ATOM 179 N THR 23 18.021 72.107 17.917
1.00 16.32 7 ATOM 180 CA THR 23 19.249 72.823 17.648 1.00 19.99 6
ATOM 181 CB THR 23 20.080 73.128 18.911 1.00 22.97 6 ATOM 182 OG1
THR 23 19.192 73.749 19.850 1.00 18.42 8 ATOM 183 CG2 THR 23 21.241
74.057 18.614 1.00 16.78 6 ATOM 184 C THR 23 20.098 72.016 16.658
1.00 24.68 6 ATOM 185 O THR 23 20.509 70.880 16.897 1.00 22.59 8
ATOM 186 N LEU 24 20.257 72.618 15.467 1.00 23.73 7 ATOM 187 CA LEU
24 21.081 72.051 14.423 1.00 23.11 6 ATOM 188 CB LEU 24 20.427
72.206 13.046 1.00 20.25 6 ATOM 189 CG LEU 24 19.053 71.480 12.959
1.00 23.95 6 ATOM 190 CD1 LEU 24 18.324 71.856 11.681 1.00 20.78 6
ATOM 191 CD2 LEU 24 19.251 69.985 13.049 1.00 22.74 6 ATOM 192 C
LEU 24 22.444 72.763 14.450 1.00 25.87 6 ATOM 193 O LEU 24 22.470
74.008 14.537 1.00 24.57 8 ATOM 194 N THR 25 23.520 71.980 14.367
1.00 20.22 7 ATOM 195 CA THR 25 24.847 72.600 14.336 1.00 23.21 6
ATOM 196 CB THR 25 25.656 72.265 15.597 1.00 27.69 6 ATOM 197 OG1
THR 25 24.945 72.730 16.755 1.00 26.30 8 ATOM 198 CG2 THR 25 27.041
72.925 15.590 1.00 28.49 6 ATOM 199 C THR 25 25.604 72.166 13.075
1.00 22.31 6 ATOM 200 O THR 25 25.706 70.951 12.819 1.00 23.86 8
ATOM 201 N CYS 26 26.092 73.134 12.307 1.00 18.68 7 ATOM 202 CA CYS
26 26.832 72.888 11.075 1.00 23.20 6 ATOM 203 C CYS 26 28.345
72.910 11.346 1.00 23.06 6 ATOM 204 O CYS 26 28.957 73.980 11.556
1.00 23.76 8 ATOM 205 CB CYS 26 26.509 73.881 9.958 1.00 17.92 6
ATOM 206 SG CYS 26 27.138 73.358 8.311 1.00 22.25 16 ATOM 207 N GLN
27 28.929 71.729 11.355 1.00 19.35 7 ATOM 208 CA GLN 27 30.332
71.521 11.658 1.00 23.30 6 ATOM 209 CB GLN 27 30.543 70.209 12.464
1.00 29.78 6 ATOM 210 CG GLN 27 29.623 70.044 13.672 1.00 31.50 6
ATOM 211 CD GLN 27 29.927 68.828 14.518 1.00 33.01 6 ATOM 212 OE1
GLN 27 30.322 67.774 14.032 1.00 38.67 8 ATOM 213 NE2 GLN 27 29.792
68.895 15.834 1.00 36.36 7 ATOM 214 C GLN 27 31.169 71.417 10.377
1.00 26.33 6 ATOM 215 O GLN 27 30.764 70.856 9.347 1.00 23.15 8
ATOM 216 N GLY 28 32.363 72.019 10.438 1.00 27.69 7 ATOM 217 CA GLY
28 33.289 72.019 9.313 1.00 28.02 6 ATOM 218 C GLY 28 34.022 73.360
9.215 1.00 29.41 6 ATOM 219 O GLY 28 33.639 74.335 9.862 1.00 28.46
8 ATOM 220 N ALA 29 35.062 73.421 8.389 1.00 27.48 7 ATOM 221 CA
ALA 29 35.824 74.640 8.210 1.00 27.39 6 ATOM 222 CB ALA 29 36.979
74.353 7.239 1.00 25.91 6 ATOM 223 C ALA 29 34.959 75.730 7.574
1.00 28.27 6 ATOM 224 O ALA 29 34.315 75.415 6.561 1.00 26.07 8
ATOM 225 N ARG 30 35.060 76.951 8.064 1.00 23.97 7 ATOM 226 CA ARG
30 34.303 78.055 7.490 1.00 27.17 6 ATOM 227 CB ARG 30 33.571
78.823 8.601 1.00 30.34 6 ATOM 228 CG ARG 30 32.574 78.090 9.460
1.00 34.05 6 ATOM 229 CD ARG 30 32.365 78.880 10.761 1.00 33.86 6
ATOM 230 NE ARG 30 32.407 77.902 11.836 1.00 38.60 7 ATOM 231 CZ
ARG 30 32.487 78.082 13.126 1.00 38.08 6 ATOM 232 NH1 ARG 30 32.567
79.298 13.635 1.00 36.51 7 ATOM 233 NH2 ARG 30 32.467 76.990 13.879
1.00 46.13 7 ATOM 234 C ARG 30 35.194 79.148 6.880 1.00 26.70 6
ATOM 235 O ARG 30 36.399 79.142 7.075 1.00 29.22 8 ATOM 236 N SER
31 34.573 80.129 6.246 1.00 26.85 7 ATOM 237 CA SER 31 35.315
81.284 5.738 1.00 26.56 6 ATOM 238 CB SER 31 34.682 81.846 4.476
1.00 25.03 6 ATOM 239 OG SER 31 34.562 80.875 3.477 1.00 27.59 8
ATOM 240 C SER 31 35.273 82.321 6.861 1.00 26.58 6 ATOM 241 O SER
31 34.396 82.246 7.739 1.00 23.91 8 ATOM 242 N PRO 32 36.163 83.308
6.839 1.00 23.48 7 ATOM 243 CD PRO 32 37.224 83.483 5.842 1.00
22.70 6 ATOM 244 CA PRO 32 36.176 84.350 7.861 1.00 24.75 6 ATOM
245 CB PRO 32 37.621 84.830 7.805 1.00 24.34 6 ATOM 246 CG PRO 32
38.095 84.571 6.414 1.00 23.77 6 ATOM 247 C PRO 32 35.172 85.449
7.549 1.00 29.23 6 ATOM 248 O PRO 32 35.472 86.609 7.223 1.00 28.28
8 ATOM 249 N GLU 33 33.913 85.121 7.709 1.00 29.77 7 ATOM 250 CA
GLU 33 32.725 85.896 7.417 1.00 33.37 6 ATOM 251 CBA GLU 33 32.177
85.426 6.073 0.50 35.18 6 ATOM 252 CBB GLU 33 32.123 85.457 6.084
0.50 31.98 6 ATOM 253 CGA GLU 33 30.795 84.829 5.952 0.50 39.40 6
ATOM 254 CGB GLU 33 31.776 83.990 5.954 0.50 34.05 6 ATOM 255 CDA
GLU 33 30.394 84.525 4.521 0.50 46.48 6 ATOM 256 CDB GLU 33 31.601
83.533 4.517 0.50 34.67 6 ATOM 257 OE1 GLU 33 29.268 84.856 4.076
0.50 49.23 8 ATOM 258 OE1 GLU 33 32.194 84.168 3.619 0.50 32.81 8
ATOM 259 OE2 GLU 33 31.232 83.952 3.788 0.50 47.50 8 ATOM 260 OE2
GLU 33 30.877 82.542 4.275 0.50 24.64 8 ATOM 261 C GLU 33 31.683
85.689 8.519 1.00 32.61 6 ATOM 262 O GLU 33 31.612 84.600 9.085
1.00 28.72 8 ATOM 263 N SER 34 30.844 86.682 8.743 1.00 32.15 7
ATOM 264 CA SER 34 29.804 86.591 9.764 1.00 32.72 6 ATOM 265 CB SER
34 29.277 88.013 10.037 1.00 34.26 6 ATOM 266 OG SER 34 28.320
87.931 11.093 1.00 45.88 8 ATOM 267 C SER 34 28.668 85.674 9.332
1.00 30.93 6 ATOM 268 O SER 34 28.156 84.883 10.124 1.00 28.87 8
ATOM 269 N ASP 35 28.222 85.773 8.082 1.00 28.02 7 ATOM 270 CA ASP
35 27.167 84.858 7.599 1.00 28.62 6 ATOM 271 CB ASP 35 26.292
85.538 6.585 1.00 29.65 6 ATOM 272 CG ASP 35 25.357 86.639 7.057
1.00 37.43 6 ATOM 273 OD1 ASP 35 25.027 86.769 8.258 1.00 33.53 8
ATOM 274 OD2 ASP 35 24.902 87.396 6.154 1.00 36.01 8 ATOM 275 C ASP
35 27.882 83.643 6.973 1.00 27.08 6 ATOM 276 O ASP 35 27.997 83.566
5.756 1.00 28.07 8 ATOM 277 N SER 36 28.461 82.748 7.774 1.00 25.55
7 ATOM 278 CA SER 36 29.282 81.680 7.225 1.00 27.45 6 ATOM 279 CB
SER 36 30.440 81.431 8.213 1.00 34.87 6 ATOM 280 OG SER 36 29.973
80.802 9.405 1.00 39.51 8 ATOM 281 C SER 36 28.558 80.382 6.890
1.00 27.14 6 ATOM 282 O SER 36 29.143 79.421 6.363 1.00 25.67 8
ATOM 283 N ILE 37 27.293 80.223 7.231 1.00 24.64 7 ATOM 284 CA ILE
37 26.580 78.973 6.977 1.00 24.33 6 ATOM 285 CB ILE 37 26.164
78.307 8.309 1.00 30.71 6 ATOM 286 CG2 ILE 37 25.561 76.931 8.032
1.00 26.94 6 ATOM 287 CG1 ILE 37 27.333 78.221 9.308 1.00 21.66 6
ATOM 288 CD1 ILE 37 28.443 77.278 8.867 1.00 27.66 6 ATOM 289 C ILE
37 25.336 79.159 6.128 1.00 24.08 6 ATOM 290 O ILE 37 24.515 80.033
6.390 1.00 23.50 8 ATOM 291 N GLN 38 25.122 78.314 5.127 1.00 24.52
7 ATOM 292 CA GLN 38 23.862 78.296 4.399 1.00 23.13 6 ATOM 293 CB
GLN 38 24.016 78.068 2.905 1.00 29.28 6 ATOM 294 CG GLN 38 24.458
79.296 2.123 1.00 29.86 6 ATOM 295 CD GLN 38 24.692 78.965 0.661
1.00 33.48 6 ATOM 296 OE1 GLN 38 25.540 78.122 0.323 1.00 28.34 8
ATOM 297 NE2 GLN 38 23.922 79.668 -0.177 1.00 38.54 7 ATOM 298 C
GLN 38 23.048 77.128 4.985 1.00 23.81 6 ATOM 299 O GLN 38 23.598
76.022 5.087 1.00 22.62 8 ATOM 300 N TRP 39 21.807 77.386 5.371
1.00 21.43 7 ATOM 301 CA TRP 39 20.987 76.304 5.905
1.00 21.73 6 ATOM 302 CB TRP 39 20.345 76.633 7.257 1.00 21.01 6
ATOM 303 CG TRP 39 21.264 76.633 8.430 1.00 17.58 6 ATOM 304 CD2
TRP 39 21.721 75.523 9.212 1.00 17.00 6 ATOM 305 CE2 TRP 39 22.569
76.033 10.220 1.00 16.71 6 ATOM 306 CE3 TRP 39 21.495 74.147 9.158
1.00 21.47 6 ATOM 307 CD1 TRP 39 21.844 77.750 8.974 1.00 19.92 6
ATOM 308 NE1 TRP 39 22.626 77.400 10.061 1.00 22.18 7 ATOM 309 CZ2
TRP 39 23.218 75.220 11.152 1.00 18.29 6 ATOM 310 CZ3 TRP 39 22.109
73.329 10.091 1.00 21.62 6 ATOM 311 CH2 TRP 39 22.960 73.874 11.064
1.00 20.15 6 ATOM 312 C TRP 39 19.890 75.993 4.898 1.00 22.76 6
ATOM 313 O TRP 39 19.407 76.925 4.238 1.00 23.42 8 ATOM 314 N PHE
40 19.533 74.701 4.758 1.00 22.91 7 ATOM 315 CA PHE 40 18.512
74.389 3.754 1.00 26.86 6 ATOM 316 CB PHE 40 19.121 73.722 2.513
1.00 24.16 6 ATOM 317 CG PHE 40 20.225 74.429 1.788 1.00 23.96 6
ATOM 318 CD1 PHE 40 21.551 74.280 2.189 1.00 23.61 6 ATOM 319 CD2
PHE 40 19.945 75.244 0.696 1.00 22.47 6 ATOM 320 CE1 PHE 40 22.564
74.919 1.504 1.00 20.83 6 ATOM 321 CE2 PHE 40 20.967 75.880 0.020
1.00 21.69 6 ATOM 322 CZ PHE 40 22.267 75.740 0.432 1.00 21.86 6
ATOM 323 C PHE 40 17.466 73.435 4.349 1.00 23.51 6 ATOM 324 O PHE
40 17.838 72.588 5.151 1.00 21.94 8 ATOM 325 N HIS 41 16.232 73.575
3.905 1.00 21.59 7 ATOM 326 CA HIS 41 15.107 72.771 4.366 1.00
24.07 6 ATOM 327 CB HIS 41 14.032 73.572 5.099 1.00 18.72 6 ATOM
328 CG HIS 41 12.864 72.727 5.548 1.00 23.41 6 ATOM 329 CD2 HIS 41
12.794 71.415 5.899 1.00 21.85 6 ATOM 330 ND1 HIS 41 11.588 73.218
5.709 1.00 21.97 7 ATOM 331 CE1 HIS 41 10.789 72.259 6.135 1.00
22.79 6 ATOM 332 NE2 HIS 41 11.504 71.161 6.268 1.00 21.87 7 ATOM
333 C HIS 41 14.455 72.163 3.115 1.00 21.83 6 ATOM 334 O HIS 41
13.972 72.919 2.282 1.00 21.37 8 ATOM 335 N ASN 42 14.576 70.847
2.959 1.00 22.08 7 ATOM 336 CA ASN 42 14.077 70.196 1.726 1.00
20.46 6 ATOM 337 CB ASN 42 12.562 70.322 1.722 1.00 18.21 6 ATOM
338 CG ASN 42 11.925 69.397 2.761 1.00 22.74 6 ATOM 339 OD1 ASN 42
12.473 68.343 3.087 1.00 24.40 8 ATOM 340 ND2 ASN 42 10.804 69.804
3.341 1.00 18.43 7 ATOM 341 C ASN 42 14.733 70.811 0.488 1.00 21.32
6 ATOM 342 O ASN 42 14.085 71.047 -0.533 1.00 20.13 8 ATOM 343 N
GLY 43 16.002 71.220 0.568 1.00 20.53 7 ATOM 344 CA GLY 43 16.767
71.861 -0.480 1.00 20.83 6 ATOM 345 C GLY 43 16.586 73.360 -0.661
1.00 24.51 6 ATOM 346 O GLY 43 17.209 73.987 -1.550 1.00 25.30 8
ATOM 347 N ASN 44 15.633 73.970 0.051 1.00 21.27 7 ATOM 348 CA ASN
44 15.391 75.393 -0.112 1.00 20.46 6 ATOM 349 CB ASN 44 13.903
75.734 0.000 1.00 23.82 6 ATOM 350 CG ASN 44 13.049 74.834 -0.891
1.00 22.26 6 ATOM 351 OD1 ASN 44 12.148 74.144 -0.409 1.00 25.47 8
ATOM 352 ND2 ASN 44 13.382 74.787 -2.171 1.00 21.59 7 ATOM 353 C
ASN 44 16.208 76.143 0.937 1.00 19.78 6 ATOM 354 O ASN 44 16.180
75.778 2.107 1.00 22.07 8 ATOM 355 N LEU 45 16.907 77.188 0.523
1.00 22.22 7 ATOM 356 CA LEU 45 17.730 77.962 1.459 1.00 21.67 6
ATOM 357 CB LEU 45 18.391 79.141 0.715 1.00 28.15 6 ATOM 358 CG LEU
45 19.159 80.171 1.538 1.00 29.14 6 ATOM 359 CD1 LEU 45 20.479
79.571 2.002 1.00 25.07 6 ATOM 360 CD2 LEU 45 19.452 81.466 0.775
1.00 28.51 6 ATOM 361 C LEU 45 16.825 78.559 2.525 1.00 22.27 6
ATOM 362 O LEU 45 15.748 78.997 2.118 1.00 20.13 8 ATOM 363 N ILE
46 17.263 78.604 3.766 1.00 20.11 7 ATOM 364 CA ILE 46 16.539
79.322 4.835 1.00 24.64 6 ATOM 365 CB ILE 46 16.657 78.508 6.132
1.00 22.24 6 ATOM 366 CG2 ILE 46 16.007 79.134 7.358 1.00 21.33 6
ATOM 367 CG1 ILE 46 16.111 77.072 5.945 1.00 20.74 6 ATOM 368 CD1
ILE 46 16.664 76.147 7.024 1.00 20.48 6 ATOM 369 C ILE 46 17.351
80.625 5.006 1.00 25.53 6 ATOM 370 O ILE 46 18.419 80.600 5.624
1.00 22.91 8 ATOM 371 N PRO 47 16.937 81.747 4.444 1.00 30.56 7
ATOM 372 CD PRO 47 15.704 81.884 3.620 1.00 32.61 6 ATOM 373 CA PRO
47 17.731 82.968 4.434 1.00 30.93 6 ATOM 374 CB PRO 47 17.030
83.836 3.363 1.00 31.28 6 ATOM 375 CG PRO 47 15.610 83.400 3.441
1.00 32.54 6 ATOM 376 C PRO 47 17.888 83.762 5.706 1.00 28.32 6
ATOM 377 O PRO 47 18.733 84.670 5.747 1.00 29.24 8 ATOM 378 N THR
48 17.092 83.513 6.730 1.00 26.79 7 ATOM 379 CA THR 48 17.135
84.298 7.971 1.00 26.97 6 ATOM 380 CB THR 48 15.698 84.323 8.532
1.00 31.78 6 ATOM 381 OG1 THR 48 15.241 82.958 8.520 1.00 31.45 8
ATOM 382 CG2 THR 48 14.798 85.150 7.605 1.00 27.40 6 ATOM 383 C THR
48 18.075 83.757 9.021 1.00 26.31 6 ATOM 384 O THR 48 18.206 84.334
10.113 1.00 28.00 8 ATOM 385 N HIS 49 18.698 82.602 8.772 1.00
24.44 7 ATOM 386 CA HIS 49 19.612 81.942 9.707 1.00 24.19 6 ATOM
387 CB HIS 49 18.953 80.610 10.174 1.00 25.11 6 ATOM 388 CG HIS 49
17.722 80.939 10.961 1.00 22.20 6 ATOM 389 CD2 HIS 49 16.430 81.109
10.624 1.00 27.86 6 ATOM 390 ND1 HIS 49 17.809 81.225 12.306 1.00
29.80 7 ATOM 391 CE1 HIS 49 16.595 81.526 12.762 1.00 28.91 6 ATOM
392 NE2 HIS 49 15.748 81.474 11.761 1.00 25.35 7 ATOM 393 C HIS 49
20.923 81.588 9.041 1.00 23.08 6 ATOM 394 O HIS 49 20.942 80.805
8.075 1.00 20.57 8 ATOM 395 N THR 50 22.038 82.162 9.497 1.00 25.11
7 ATOM 396 CA THR 50 23.321 81.974 8.807 1.00 22.98 6 ATOM 397 CB
THR 50 23.732 83.314 8.137 1.00 23.01 6 ATOM 398 OG1 THR 50 23.843
84.252 9.231 1.00 18.66 8 ATOM 399 CG2 THR 50 22.757 83.817 7.101
1.00 19.07 6 ATOM 400 C THR 50 24.460 81.645 9.766 1.00 24.61 6
ATOM 401 O THR 50 25.640 81.772 9.393 1.00 26.17 8 ATOM 402 N GLN
51 24.126 81.274 10.985 1.00 24.52 7 ATOM 403 CA GLN 51 25.132
80.979 11.995 1.00 27.31 6 ATOM 404 CB GLN 51 24.708 81.505 13.378
1.00 28.63 6 ATOM 405 CG GLN 51 24.438 83.014 13.378 1.00 32.81 6
ATOM 406 CD GLN 51 25.677 83.810 12.995 1.00 38.53 6 ATOM 407 OE1
GLN 51 26.606 83.952 13.802 1.00 37.60 8 ATOM 408 NE2 GLN 51 25.724
84.331 11.765 1.00 32.79 7 ATOM 409 C GLN 51 25.411 79.487 12.101
1.00 26.69 6 ATOM 410 O GLN 51 24.626 78.636 11.689 1.00 26.27 8
ATOM 411 N PRO 52 26.510 79.138 12.769 1.00 25.16 7 ATOM 412 CD PRO
52 27.553 80.091 13.270 1.00 24.54 6 ATOM 413 CA PRO 52 26.917
77.763 12.974 1.00 25.24 6 ATOM 414 CB PRO 52 28.264 77.888 13.708
1.00 26.09 6 ATOM 415 CG PRO 52 28.804 79.217 13.257 1.00 23.35 6
ATOM 416 C PRO 52 25.900 76.915 13.722 1.00 25.71 6 ATOM 417 O PRO
52 25.877 75.687 13.542 1.00 21.61 8 ATOM 418 N SER 53 25.044
77.497 14.556 1.00 24.05 7 ATOM 419 CA SER 53 23.991 76.773 15.239
1.00 25.63 6 ATOM 420 CB SER 53 24.105 76.711 16.758 1.00 31.86 6
ATOM 421 OG SER 53 24.778 75.495 17.094 1.00 42.46 8 ATOM 422 C SER
53 22.681 77.460 14.854 1.00 24.85 6 ATOM 423 O SER 53 22.681
78.673 14.691 1.00 23.68 8 ATOM 424 N TYR 54 21.658 76.689 14.614
1.00 24.52 7 ATOM 425 CA TYR 54 20.333 77.167 14.212 1.00 26.29 6
ATOM 426 CB TYR 54 20.050 76.886 12.729 1.00 26.92 6 ATOM 427 CG
TYR 54 18.612 76.998 12.274 1.00 30.15 6 ATOM 428 CD1 TYR 54 17.719
77.905 12.825 1.00 29.18 6 ATOM 429 CE1 TYR 54 16.407 78.006 12.409
1.00 31.26 6 ATOM 430 CD2 TYR 54 18.104 76.166 11.280 1.00 31.67 6
ATOM 431 CE2 TYR 54 16.796 76.217 10.855 1.00 31.66 6 ATOM 432 CZ
TYR 54 15.950 77.151 11.429 1.00 33.63 6 ATOM 433 OH TYR 54 14.624
77.219 11.038 1.00 34.53 8 ATOM 434 C TYR 54 19.378 76.450 15.167
1.00 24.84 6 ATOM 435 O TYR 54 19.300 75.210 15.129 1.00 22.53 8
ATOM 436 N ARG 55 18.773 77.181 16.070 1.00 21.66 7 ATOM 437 CA ARG
55 17.864 76.650 17.070 1.00 23.60 6 ATOM 438 CB ARG 55 18.242
77.157 18.480 1.00 25.95 6 ATOM 439 CG ARG 55 17.478 76.340 19.551
1.00 23.98 6 ATOM 440 CD ARG 55 17.651 76.982 20.918 1.00 35.38 6
ATOM 441 NE ARG 55 16.821 76.365 21.956 1.00 27.47 7 ATOM 442 CZ
ARG 55 17.278 75.530 22.879 1.00 33.10 6 ATOM 443 NH1 ARG 55 18.570
75.209 22.904 1.00 30.00 7 ATOM 444 NH2 ARG 55 16.418 75.049 23.778
1.00 32.66 7 ATOM 445 C ARG 55 16.434 77.103 16.802 1.00 27.49 6
ATOM 446 O ARG 55 16.275 78.312 16.569 1.00 22.62 8 ATOM 447 N PHE
56 15.455 76.174 16.781 1.00 23.78 7 ATOM 448 CA PHE 56 14.092
76.636 16.510 1.00 21.92 6 ATOM 449 CB PHE 56 13.716 76.495 15.036
1.00 25.99 6 ATOM 450 CG PHE 56 13.819 75.131 14.386 1.00 20.84 6
ATOM 451 CD1 PHE 56 15.019 74.653 13.897 1.00 21.33 6 ATOM 452 CD2
PHE 56 12.705 74.319 14.264 1.00 20.31 6 ATOM 453 CE1 PHE 56 15.103
73.415 13.283 1.00 21.52 6 ATOM 454 CE2 PHE 56 12.768 73.077 13.680
1.00 18.36 6 ATOM 455 CZ PHE 56 13.973 72.616 13.159 1.00 18.38 6
ATOM 456 C PHE 56 13.095 75.862 17.372 1.00 23.93 6 ATOM 457 O PHE
56 13.454 74.833 17.921 1.00 22.42 8 ATOM 458 N LYS 57 11.865
76.340 17.423 1.00 22.46 7 ATOM 459 CA LYS 57 10.735 75.659 18.054
1.00 24.34 6 ATOM 460 CBA LYS 57 9.892 76.620 18.881 0.50 28.51 6
ATOM 461 CBB LYS 57 9.822 76.727 18.669 0.50 22.87 6 ATOM 462 CGA
LYS 57 10.656 77.298 20.010 0.50 33.64 6 ATOM 463 CGB LYS 57 8.769
76.208 19.632 0.50 24.29 6 ATOM 464 CDA LYS 57 11.436 76.342 20.892
0.50 40.75 6 ATOM 465 CDB LYS 57 8.631 77.186 20.798 0.50 26.90 6
ATOM 466 CEA LYS 57 12.612 76.990 21.603 0.50 43.07 6 ATOM 467 CEB
LYS 57 9.138 76.604 22.092 0.50 29.79 6 ATOM 468 NZA LYS 57 12.703
76.630 23.044 0.50 51.71 7 ATOM 469 NZB LYS 57 8.050 76.265 23.060
0.50 36.22 7 ATOM 470 C LYS 57 9.950 74.923 16.969 1.00 21.30 6
ATOM 471 O LYS 57 9.436 75.551 16.052 1.00 19.46 8 ATOM 472 N ALA
58 9.928 73.588 16.945 1.00 18.23 7 ATOM 473 CA ALA 58 9.341 72.864
15.821 1.00 15.74 6 ATOM 474 CB ALA 58 9.612 71.361 16.094 1.00
9.09 6 ATOM 475 C ALA 58 7.841 73.034 15.614 1.00 20.26 6 ATOM 476
O ALA 58 7.067 73.064 16.574 1.00 18.04 8 ATOM 477 N ASN 59 7.392
73.126 14.367 1.00 18.31 7 ATOM 478 CA ASN 59 5.986 73.071 14.019
1.00 23.04 6 ATOM 479 CB ASN 59 5.222 74.301 13.612 1.00 32.39 6
ATOM 480 CG ASN 59 5.880 75.643 13.665 1.00 38.26 6 ATOM 481 OD1
ASN 59 5.855 76.279 14.716 1.00 42.50 8 ATOM 482 ND2 ASN 59 6.426
76.066 12.529 1.00 43.39 7 ATOM 483 C ASN 59 5.825 72.052 12.867
1.00 24.07 6 ATOM 484 O ASN 59 6.794 71.476 12.365 1.00 21.25 8
ATOM 485 N ASN 60 4.582 71.833 12.484 1.00 24.40 7 ATOM 486 CA ASN
60 4.192 70.823 11.519 1.00 31.47 6 ATOM 487 CB ASN 60 2.680 70.893
11.234 1.00 31.46 6 ATOM 488 CGA ASN 60 2.272 69.776 10.274 0.50
31.26 6 ATOM 489 CGB ASN 60 2.221 72.272 10.814 0.50 35.72 6 ATOM
490 OD1 ASN 60 2.337 68.582 10.597 0.50 22.52 8 ATOM 491 OD1 ASN 60
2.985 73.240 10.768 0.50 33.04 8 ATOM 492 ND2 ASN 60 1.863 70.175
9.070 0.50 26.04 7 ATOM 493 ND2 ASN 60 0.932 72.391 10.483 0.50
39.47 7 ATOM 494 C ASN 60 5.006 70.943 10.234 1.00 29.05 6 ATOM 495
O ASN 60 5.645 69.986 9.780 1.00 32.27 8 ATOM 496 N ASN 61 5.098
72.153 9.710 1.00 30.20 7 ATOM 497 CAA ASN 61 5.863 72.487 8.529
0.50 28.68 6 ATOM 498 CAB ASN 61 5.857 72.367 8.477 0.50 29.13 6
ATOM 499 CBA ASN 61 5.564 73.955 8.150 0.50 26.19 6 ATOM 500 CBB
ASN 61 5.403 73.671 7.806 0.50 30.25 6 ATOM 501 CGA ASN 61 4.101
74.127 7.792 0.50 27.01 6 ATOM 502 CGB ASN 61 5.608 74.882 8.678
0.50 32.36 6 ATOM 503 OD1 ASN 61 3.502 75.125 8.184 0.50 28.58 8
ATOM 504 OD1 ASN 61 6.383 74.820 9.637 0.50 33.38 8 ATOM 505 ND2
ASN 61 3.526 73.172 7.071 0.50 34.39 7 ATOM 506 ND2 ASN 61 4.927
75.991 8.384 0.50 33.52 7 ATOM 507 C ASN 61 7.371 72.336 8.628 1.00
25.33 6 ATOM 508 O ASN 61 8.030 72.535 7.617 1.00 21.46 8 ATOM 509
N ASP 62 7.932 71.978 9.767 1.00 24.89 7 ATOM 510 CA ASP 62 9.373
71.842 9.941 1.00 21.37 6 ATOM 511 CB ASP 62 9.749 72.284 11.372
1.00 16.89 6 ATOM 512 CG ASP 62 9.620 73.782 11.538 1.00 26.20 6
ATOM 513 OD1 ASP 62 9.824 74.549 10.570 1.00 20.81 8 ATOM 514 OD2
ASP 62 9.276 74.273 12.611 1.00 17.90 8 ATOM 515 C ASP 62 9.887
70.439 9.645 1.00 18.69 6 ATOM 516 O ASP 62 11.104 70.209 9.654
1.00 20.50 8 ATOM 517 N SER 63 9.011 69.477 9.394 1.00 19.81 7 ATOM
518 CA SER 63 9.434 68.132 9.015 1.00 19.84 6 ATOM 519 CB SER 63
8.268 67.164 8.811 1.00 22.04 6 ATOM 520 OG SER 63 7.506 67.018
10.009 1.00 20.02 8 ATOM 521 C SER 63 10.196 68.204 7.682 1.00
23.89 6 ATOM 522 O SER 63 10.015 69.160 6.911 1.00 17.92 8 ATOM 523
N GLY 64 11.056 67.195 7.467 1.00 19.50 7 ATOM 524 CA GLY 64 11.769
67.191 6.190 1.00 22.23 6 ATOM 525 C GLY 64 13.272 66.965 6.340
1.00 19.81 6 ATOM 526 O GLY 64 13.744 66.564 7.399 1.00 18.93 8
ATOM 527 N GLU 65 13.980 67.226 5.238 1.00 17.01 7 ATOM 528 CA GLU
65 15.428 67.013 5.269 1.00 21.39 6 ATOM 529 CBA GLU 65 15.934
66.562 3.901 0.50 13.64 6 ATOM 530 CBB GLU 65 15.933 66.446 3.947
0.50 23.81 6 ATOM 531 CGA GLU 65 16.507 65.158 3.813 0.50 15.71 6
ATOM 532 CGB GLU 65 15.409 65.059 3.602 0.50 32.15 6 ATOM 533 CDA
GLU 65 16.656 64.679 2.381 0.50 22.33 6 ATOM 534 CDB GLU 65 15.898
63.965 4.520 0.50 40.56 6 ATOM 535 OE1 GLU 65 17.428 65.263 1.586
0.50 22.70 8 ATOM 536 OE1 GLU 65 16.578 64.271 5.525 0.50 41.83 8
ATOM 537 OE2 GLU 65 15.991 63.686 2.014 0.50 31.04 8 ATOM 538 OE2
GLU 65 15.624 62.758 4.278 0.50 46.02 8 ATOM 539 C GLU 65 16.155
68.324 5.593 1.00 21.56 6 ATOM 540 O GLU 65 15.756 69.325 5.007
1.00 21.41 8 ATOM 541 N TYR 66 17.172 68.268 6.458 1.00 21.38 7
ATOM 542 CA TYR 66 17.966 69.483 6.691 1.00 17.91 6 ATOM 543 CB TYR
66 17.954 69.984 8.129 1.00 17.39 6 ATOM 544 CG TYR 66 16.620
70.563 8.534 1.00 18.08 6 ATOM 545 CD1 TYR 66 15.605 69.686 8.957
1.00 18.56 6 ATOM 546 CE1 TYR 66 14.369 70.147 9.323 1.00 16.48 6
ATOM 547 CD2 TYR 66 16.348 71.921 8.485 1.00 18.23 6 ATOM 548 CE2
TYR 66 15.102 72.382 8.867 1.00 18.37 6 ATOM 549 CZ TYR 66 14.124
71.516 9.279 1.00 18.98 6 ATOM 550 OH TYR 66 12.872 71.939 9.624
1.00 14.14 8 ATOM 551 C TYR 66 19.379 69.231 6.212 1.00 13.96 6
ATOM 552 O TYR 66 19.923 68.135 6.353 1.00 18.14 8 ATOM 553 N THR
67 20.010 70.228 5.568 1.00 17.95 7 ATOM 554 CA THR 67 21.374
70.138 5.117 1.00 18.06 6 ATOM 555 CB THR 67 21.514 69.844 3.599
1.00 22.52 6 ATOM 556 OG1 THR 67 20.669 70.737 2.835 1.00 16.85 8
ATOM 557 CG2 THR 67 21.215 68.371 3.309 1.00 17.46 6 ATOM 558 C THR
67 22.044 71.508 5.384 1.00 18.76 6 ATOM 559 O THR 67 21.354 72.515
5.567 1.00 17.47 8 ATOM 560 N CYS 68 23.354 71.540 5.389 1.00 19.74
7 ATOM 561 CA CYS 68 24.099 72.792 5.597 1.00 23.50 6 ATOM 562 C
CYS 68 25.382 72.759 4.758 1.00 23.12 6 ATOM 563 O CYS 68 25.791
71.712 4.279 1.00 25.07 8 ATOM 564 CB CYS 68 24.434 73.082 7.055
1.00 18.70 6 ATOM 565 SG CYS 68 25.675 71.985 7.798 1.00 23.45 16
ATOM 566 N GLN 69 25.975 73.920 4.534 1.00 24.47 7 ATOM 567 CA GLN
69 27.174 74.121 3.770 1.00 24.99 6 ATOM 568 CB GLN 69 26.909
74.344 2.264 1.00 27.22 6 ATOM 569 CG GLN 69 28.155 74.057 1.419
1.00 25.14 6 ATOM 570 CD GLN 69 27.857 74.022 -0.065 1.00 32.43 6
ATOM 571 OE1 GLN 69 26.710 74.166 -0.487 1.00 31.34 8 ATOM 572 NE2
GLN 69 28.896 73.814 -0.874 1.00 27.89 7 ATOM 573 C GLN 69 27.901
75.383 4.266 1.00 27.60 6 ATOM 574 O GLN 69 27.289 76.352 4.734
1.00 25.37 8 ATOM 575 N THR 70 29.206 75.318 4.115 1.00 28.73 7
ATOM 576 CA THR 70 30.059 76.465 4.439 1.00 32.10 6 ATOM 577 CB THR
70 31.125 76.153 5.491 1.00 33.36 6 ATOM 578 OG1 THR 70 30.619
75.311 6.553 1.00 45.26 8 ATOM 579 CG2 THR 70 31.453 77.444 6.210
1.00 50.20 6 ATOM 580 C THR 70 30.737 76.890 3.138 1.00 32.77 6
ATOM 581 O THR 70 30.680 76.170 2.130 1.00 30.75 8 ATOM 582 N GLY
71 31.472 78.007 3.175 1.00 31.83 7 ATOM 583 CA GLY 71 32.224
78.469 2.033 1.00 27.97 6 ATOM 584 C GLY 71 33.376 77.544 1.690
1.00 29.94 6 ATOM 585 O GLY 71 33.938 77.668 0.596 1.00 32.37 8
ATOM 586 N GLN 72 33.842 76.707 2.594 1.00 24.86 7 ATOM 587 CA GLN
72 34.920 75.779 2.457 1.00 27.14 6 ATOM 588 CB GLN 72 35.868
75.974 3.667 1.00 27.31 6 ATOM 589 CG GLN 72 36.291 77.451 3.825
1.00 30.51 6 ATOM 590 CD GLN 72 36.961 77.995 2.567 1.00 30.53 6
ATOM 591 OE1 GLN 72 37.981 77.441 2.161 1.00 39.95 8 ATOM 592 NE2
GLN 72 36.402 79.014 1.944 1.00 31.16 7 ATOM 593 C GLN 72 34.530
74.305 2.441 1.00 29.60 6 ATOM 594 O GLN 72 35.419 73.442 2.578
1.00 30.82 8 ATOM 595 N THR 73 33.248 73.954 2.380 1.00 25.83 7
ATOM 596 CA THR 73 32.861 72.549 2.426 1.00 26.62 6 ATOM 597 CB THR
73 32.278 72.135 3.792 1.00 26.64 6 ATOM 598 OG1 THR 73 31.226
73.051 4.138 1.00 27.54 8 ATOM 599 CG2 THR 73 33.313 72.124 4.897
1.00 28.16 6 ATOM 600 C THR 73 31.824 72.223 1.371 1.00 26.31 6
ATOM 601 O THR 73 31.210 73.110 0.776 1.00 28.00 8 ATOM 602 N SER
74 31.685 70.927 1.074 1.00 28.62 7 ATOM 603 CA SER 74 30.592
70.605 0.112 1.00 29.44 6 ATOM 604 CB SER 74 31.020 69.470 -0.803
1.00 30.45 6 ATOM 605 OG SER 74 31.407 68.399 0.034 1.00 41.05 8
ATOM 606 C SER 74 29.366 70.395 0.992 1.00 26.65 6 ATOM 607 O SER
74 29.461 70.438 2.228
1.00 25.57 8 ATOM 608 N LEU 75 28.178 70.281 0.442 1.00 29.47 7
ATOM 609 CA LEU 75 26.915 70.163 1.158 1.00 25.10 6 ATOM 610 CB LEU
75 25.749 70.141 0.159 1.00 27.83 6 ATOM 611 CG LEU 75 24.348
70.136 0.777 1.00 27.24 6 ATOM 612 CD1 LEU 75 23.888 71.554 1.094
1.00 24.13 6 ATOM 613 CD2 LEU 75 23.349 69.420 -0.133 1.00 24.42 6
ATOM 614 C LEU 75 26.884 68.973 2.087 1.00 25.84 6 ATOM 615 O LEU
75 27.300 67.858 1.711 1.00 22.45 8 ATOM 616 N SER 76 26.376 69.158
3.315 1.00 23.31 7 ATOM 617 CA SER 76 26.357 68.009 4.219 1.00
25.20 6 ATOM 618 CB SER 76 25.916 68.402 5.644 1.00 26.64 6 ATOM
619 OG SER 76 24.514 68.663 5.624 1.00 29.43 8 ATOM 620 C SER 76
25.346 66.955 3.738 1.00 23.00 6 ATOM 621 O SER 76 24.431 67.304
3.006 1.00 21.02 8 ATOM 622 N ASP 77 25.506 65.739 4.241 1.00 22.24
7 ATOM 623 CA ASP 77 24.493 64.712 4.094 1.00 26.03 6 ATOM 624 CB
ASP 77 24.907 63.362 4.683 1.00 20.27 6 ATOM 625 CG ASP 77 25.914
62.676 3.758 1.00 25.73 6 ATOM 626 OD1 ASP 77 25.821 62.893 2.541
1.00 23.79 8 ATOM 627 OD2 ASP 77 26.769 61.954 4.292 1.00 28.92 8
ATOM 628 C ASP 77 23.267 65.191 4.929 1.00 25.85 6 ATOM 629 O ASP
77 23.423 65.904 5.914 1.00 24.00 8 ATOM 630 N PRO 78 22.098 64.758
4.492 1.00 27.37 7 ATOM 631 CD PRO 78 21.917 63.917 3.275 1.00
26.84 6 ATOM 632 CA PRO 78 20.849 65.130 5.098 1.00 25.42 6 ATOM
633 CB PRO 78 19.795 64.592 4.141 1.00 28.38 6 ATOM 634 CG PRO 78
20.453 63.586 3.272 1.00 27.24 6 ATOM 635 C PRO 78 20.575 64.556
6.479 1.00 25.28 6 ATOM 636 O PRO 78 21.006 63.459 6.820 1.00 23.68
8 ATOM 637 N VAL 79 19.833 65.331 7.265 1.00 20.24 7 ATOM 638 CA
VAL 79 19.287 64.861 8.535 1.00 18.86 6 ATOM 639 CB VAL 79 19.850
65.516 9.783 1.00 19.49 6 ATOM 640 CG1 VAL 79 19.042 65.239 11.046
1.00 22.25 6 ATOM 641 CG2 VAL 79 21.275 64.959 10.036 1.00 21.95 6
ATOM 642 C VAL 79 17.777 65.046 8.399 1.00 19.76 6 ATOM 643 O VAL
79 17.283 66.130 8.076 1.00 22.34 8 ATOM 644 N HIS 80 17.024 63.955
8.566 1.00 19.43 7 ATOM 645 CA HIS 80 15.584 63.976 8.387 1.00
18.11 6 ATOM 646 CB HIS 80 15.130 62.621 7.784 1.00 26.87 6 ATOM
647 CG HIS 80 13.712 62.754 7.293 1.00 31.93 6 ATOM 648 CD2 HIS 80
13.194 62.983 6.069 1.00 27.05 6 ATOM 649 ND1 HIS 80 12.637 62.697
8.176 1.00 34.35 7 ATOM 650 CE1 HIS 80 11.525 62.847 7.480 1.00
34.80 6 ATOM 651 NE2 HIS 80 11.831 63.016 6.210 1.00 34.81 7 ATOM
652 C HIS 80 14.865 64.187 9.718 1.00 23.08 6 ATOM 653 O HIS 80
15.096 63.496 10.709 1.00 23.37 8 ATOM 654 N LEU 81 13.953 65.138
9.747 1.00 19.18 7 ATOM 655 CA LEU 81 13.244 65.478 10.957 1.00
21.58 6 ATOM 656 CB LEU 81 13.567 66.937 11.331 1.00 18.20 6 ATOM
657 CG LEU 81 12.847 67.381 12.605 1.00 18.21 6 ATOM 658 CD1 LEU 81
13.496 66.708 13.812 1.00 19.39 6 ATOM 659 CD2 LEU 81 12.865 68.912
12.696 1.00 14.76 6 ATOM 660 C LEU 81 11.747 65.255 10.783 1.00
19.36 6 ATOM 661 O LEU 81 11.225 65.543 9.720 1.00 20.96 8 ATOM 662
N THR 82 11.100 64.689 11.793 1.00 19.61 7 ATOM 663 CA THR 82 9.642
64.463 11.680 1.00 18.45 6 ATOM 664 CB THR 82 9.316 62.950 11.683
1.00 25.98 6 ATOM 665 OG1 THR 82 9.907 62.351 10.527 1.00 18.89 8
ATOM 666 CG2 THR 82 7.795 62.775 11.666 1.00 24.98 6 ATOM 667 C THR
82 8.971 65.100 12.891 1.00 16.02 6 ATOM 668 O THR 82 9.248 64.735
14.035 1.00 14.79 8 ATOM 669 N VAL 83 8.075 66.045 12.647 1.00
16.23 7 ATOM 670 CA VAL 83 7.451 66.758 13.753 1.00 16.97 6 ATOM
671 CB VAL 83 7.559 68.282 13.530 1.00 12.81 6 ATOM 672 CG1 VAL 83
7.051 68.972 14.799 1.00 15.92 6 ATOM 673 CG2 VAL 83 8.986 68.760
13.246 1.00 11.78 6 ATOM 674 C VAL 83 6.020 66.264 13.892 1.00
19.97 6 ATOM 675 O VAL 83 5.261 66.329 12.918 1.00 18.57 8 ATOM 676
N LEU 84 5.686 65.756 15.075 1.00 16.89 7 ATOM 677 CA LEU 84 4.372
65.188 15.312 1.00 19.89 6 ATOM 678 CB LEU 84 4.621 63.786 15.890
1.00 18.15 6 ATOM 679 CG LEU 84 5.491 62.863 15.021 1.00 23.40 6
ATOM 680 CD1 LEU 84 5.927 61.690 15.868 1.00 25.20 6 ATOM 681 CD2
LEU 84 4.752 62.396 13.758 1.00 20.46 6 ATOM 682 C LEU 84 3.487
66.016 16.228 1.00 22.29 6 ATOM 683 O LEU 84 3.928 66.891 16.975
1.00 23.90 8 ATOM 684 N PHE 85 2.189 65.750 16.218 1.00 21.03 7
ATOM 685 CA PHE 85 1.254 66.444 17.111 1.00 22.92 6 ATOM 686 CB PHE
85 0.399 67.431 16.333 1.00 21.76 6 ATOM 687 CG PHE 85 -0.440
68.350 17.184 1.00 27.90 6 ATOM 688 CD1 PHE 85 0.103 69.013 18.266
1.00 28.30 6 ATOM 689 CD2 PHE 85 -1.787 68.533 16.899 1.00 26.61 6
ATOM 690 CE1 PHE 85 -0.664 69.874 19.040 1.00 29.65 6 ATOM 691 CE2
PHE 85 -2.559 69.386 17.668 1.00 25.61 6 ATOM 692 CZ PHE 85 -1.996
70.047 18.733 1.00 28.75 6 ATOM 693 C PHE 85 0.455 65.399 17.852
1.00 21.99 6 ATOM 694 O PHE 85 -0.642 65.000 17.426 1.00 22.11 8
ATOM 695 N GLU 86 1.023 64.883 18.938 1.00 20.76 7 ATOM 696 CA GLU
86 0.421 63.762 19.702 1.00 18.04 6 ATOM 697 CB GLU 86 1.142 62.463
19.210 1.00 20.84 6 ATOM 698 CG GLU 86 0.711 61.815 17.911 1.00
25.05 6 ATOM 699 CD GLU 86 1.647 61.048 17.019 1.00 41.96 6 ATOM
700 OE1 GLU 86 2.719 60.507 17.416 1.00 46.14 8 ATOM 701 OE2 GLU 86
1.429 60.893 15.765 1.00 40.77 8 ATOM 702 C GLU 86 0.694 64.026
21.176 1.00 18.46 6 ATOM 703 O GLU 86 1.588 64.839 21.462 1.00
16.67 8 ATOM 704 N TRP 87 0.031 63.408 22.156 1.00 12.60 7 ATOM 705
CA TRP 87 0.328 63.631 23.553 1.00 13.01 6 ATOM 706 CB TRP 87
-0.808 63.056 24.411 1.00 18.40 6 ATOM 707 CG TRP 87 -1.922 64.023
24.687 1.00 21.87 6 ATOM 708 CD2 TRP 87 -1.812 65.176 25.521 1.00
21.14 6 ATOM 709 CE2 TRP 87 -3.065 65.805 25.526 1.00 24.31 6 ATOM
710 CE3 TRP 87 -0.767 65.738 26.255 1.00 24.84 6 ATOM 711 CD1 TRP
87 -3.216 63.985 24.231 1.00 22.52 6 ATOM 712 NE1 TRP 87 -3.907
65.069 24.734 1.00 22.53 7 ATOM 713 CZ2 TRP 87 -3.303 66.966 26.266
1.00 29.91 6 ATOM 714 CZ3 TRP 87 -0.998 66.890 26.987 1.00 29.83 6
ATOM 715 CH2 TRP 87 -2.254 67.499 26.970 1.00 29.09 6 ATOM 716 C
TRP 87 1.599 62.967 24.068 1.00 15.44 6 ATOM 717 O TRP 87 2.178
63.499 25.018 1.00 16.68 8 ATOM 718 N LEU 88 2.036 61.873 23.447
1.00 14.44 7 ATOM 719 CA LEU 88 3.153 61.051 23.861 1.00 20.07 6
ATOM 720 CB LEU 88 2.596 59.942 24.783 1.00 17.49 6 ATOM 721 CG LEU
88 3.608 59.303 25.769 1.00 16.97 6 ATOM 722 CD1 LEU 88 4.062
60.299 26.830 1.00 17.38 6 ATOM 723 CD2 LEU 88 2.987 58.053 26.370
1.00 13.93 6 ATOM 724 C LEU 88 3.889 60.399 22.677 1.00 20.44 6
ATOM 725 O LEU 88 3.255 59.857 21.752 1.00 19.65 8 ATOM 726 N VAL
89 5.218 60.517 22.620 1.00 18.11 7 ATOM 727 CA VAL 89 5.998 59.926
21.542 1.00 14.66 6 ATOM 728 CBA VAL 89 6.686 61.029 20.699 0.50
7.52 6 ATOM 729 CBB VAL 89 6.677 60.941 20.604 0.50 13.86 6 ATOM
730 CG1 VAL 89 7.573 61.890 21.597 0.50 7.13 6 ATOM 731 CG1 VAL 89
5.696 61.409 19.543 0.50 15.87 6 ATOM 732 CG2 VAL 89 7.501 60.486
19.531 0.50 3.91 6 ATOM 733 CG2 VAL 89 7.264 62.090 21.402 0.50
18.65 6 ATOM 734 C VAL 89 7.109 59.032 22.107 1.00 15.71 6 ATOM 735
O VAL 89 7.689 59.262 23.179 1.00 14.52 8 ATOM 736 N LEU 90 7.379
57.958 21.386 1.00 15.13 7 ATOM 737 CA LEU 90 8.520 57.133 21.703
1.00 13.72 6 ATOM 738 CB LEU 90 8.287 55.625 21.488 1.00 17.87 6
ATOM 739 CG LEU 90 9.650 54.978 21.873 1.00 26.07 6 ATOM 740 CD1
LEU 90 9.479 54.066 23.036 1.00 30.57 6 ATOM 741 CD2 LEU 90 10.373
54.463 20.662 1.00 25.07 6 ATOM 742 C LEU 90 9.657 57.674 20.803
1.00 17.58 6 ATOM 743 O LEU 90 9.611 57.517 19.576 1.00 14.46 8
ATOM 744 N GLN 91 10.673 58.298 21.412 1.00 15.83 7 ATOM 745 CA GLN
91 11.745 58.908 20.623 1.00 17.70 6 ATOM 746 CB GLN 91 12.252
60.238 21.264 1.00 15.03 6 ATOM 747 CG GLN 91 11.105 61.231 21.472
1.00 12.81 6 ATOM 748 CD GLN 91 11.564 62.636 21.868 1.00 15.79 6
ATOM 749 OE1 GLN 91 12.023 62.823 22.988 1.00 14.61 8 ATOM 750 NE2
GLN 91 11.409 63.610 20.984 1.00 16.27 7 ATOM 751 C GLN 91 12.971
58.042 20.375 1.00 17.71 6 ATOM 752 O GLN 91 13.370 57.296 21.268
1.00 19.37 8 ATOM 753 N THR 92 13.607 58.207 19.218 1.00 14.05 7
ATOM 754 CA THR 92 14.853 57.488 18.934 1.00 19.01 6 ATOM 755 CB
THR 92 14.562 56.225 18.089 1.00 16.40 6 ATOM 756 OG1 THR 92 15.769
55.485 17.905 1.00 18.39 8 ATOM 757 CG2 THR 92 13.943 56.499 16.720
1.00 10.45 6 ATOM 758 C THR 92 15.803 58.416 18.173 1.00 18.96 6
ATOM 759 O THR 92 15.339 59.272 17.409 1.00 21.88 8 ATOM 760 N PRO
93 17.095 58.153 18.251 1.00 18.78 7 ATOM 761 CD PRO 93 17.747
57.169 19.135 1.00 22.16 6 ATOM 762 CA PRO 93 18.090 58.929 17.530
1.00 24.37 6 ATOM 763 CB PRO 93 19.352 58.803 18.371 1.00 24.99 6
ATOM 764 CG PRO 93 19.162 57.609 19.235 1.00 26.05 6 ATOM 765 C PRO
93 18.285 58.362 16.138 1.00 27.02 6 ATOM 766 O PRO 93 18.852
59.019 15.248 1.00 27.04 8 ATOM 767 N HIS 94 17.978 57.069 15.960
1.00 24.22 7 ATOM 768 CA HIS 94 18.114 56.421 14.651 1.00 25.72 6
ATOM 769 CB HIS 94 19.444 55.690 14.439 1.00 20.09 6 ATOM 770 CG
HIS 94 20.639 56.587 14.595 1.00 21.67 6 ATOM 771 CD2 HIS 94 21.161
57.530 13.798 1.00 23.30 6 ATOM 772 ND1 HIS 94 21.380 56.595 15.754
1.00 27.49 7 ATOM 773 CE1 HIS 94 22.338 57.501 15.657 1.00 26.54 6
ATOM 774 NE2 HIS 94 22.211 58.078 14.482 1.00 32.10 7 ATOM 775 C
HIS 94 17.038 55.350 14.453 1.00 24.49 6 ATOM 776 O HIS 94 16.481
54.838 15.429 1.00 24.01 8 ATOM 777 N LEU 95 16.847 54.929 13.214
1.00 21.96 7 ATOM 778 CA LEU 95 15.900 53.847 12.960 1.00 26.06 6
ATOM 779 CB LEU 95 15.014 54.118 11.741 1.00 26.66 6 ATOM 780 CG
LEU 95 13.994 55.248 11.899 1.00 35.19 6 ATOM 781 CD1 LEU 95 13.449
55.601 10.525 1.00 25.66 6 ATOM 782 CD2 LEU 95 12.895 54.908 12.900
1.00 24.13 6 ATOM 783 C LEU 95 16.626 52.525 12.720 1.00 26.30 6
ATOM 784 O LEU 95 15.999 51.464 12.790 1.00 26.83 8 ATOM 785 N GLU
96 17.884 52.601 12.326 1.00 25.44 7 ATOM 786 CA GLU 96 18.688
51.413 12.087 1.00 28.55 6 ATOM 787 CB GLU 96 19.062 51.144 10.634
1.00 28.97 6 ATOM 788 CG GLU 96 17.977 51.334 9.605 1.00 34.46 6
ATOM 789 CD GLU 96 18.414 51.109 8.168 1.00 42.07 6 ATOM 790 OE1
GLU 96 19.560 50.709 7.882 1.00 41.53 8 ATOM 791 OE2 GLU 96 17.592
51.343 7.256 1.00 45.31 8 ATOM 792 C GLU 96 19.995 51.575 12.885
1.00 32.22 6 ATOM 793 O GLU 96 20.525 52.686 13.015 1.00 31.68 8
ATOM 794 N PHE 97 20.396 50.487 13.538 1.00 29.38 7 ATOM 795 CA PHE
97 21.622 50.447 14.315 1.00 31.45 6 ATOM 796 CB PHE 97 21.388
50.351 15.832 1.00 29.88 6 ATOM 797 CG PHE 97 20.640 51.497 16.464
1.00 28.91 6 ATOM 798 CD1 PHE 97 19.256 51.580 16.386 1.00 19.88 6
ATOM 799 CD2 PHE 97 21.311 52.503 17.131 1.00 27.06 6 ATOM 800 CE1
PHE 97 18.557 52.624 16.971 1.00 23.29 6 ATOM 801 CE2 PHE 97 20.622
53.545 17.719 1.00 23.27 6 ATOM 802 CZ PHE 97 19.244 53.626 17.636
1.00 25.87 6 ATOM 803 C PHE 97 22.455 49.233 13.861 1.00 31.11 6
ATOM 804 O PHE 97 22.007 48.334 13.164 1.00 32.31 8 ATOM 805 N GLN
98 23.726 49.213 14.219 1.00 34.14 7 ATOM 806 CA GLN 98 24.636
48.131 13.939 1.00 33.31 6 ATOM 807 CB GLN 98 26.042 48.629 13.635
1.00 38.15 6 ATOM 808 CG GLN 98 26.207 49.422 12.356 1.00 45.65 6
ATOM 809 CD GLN 98 25.763 48.712 11.097 1.00 49.99 6 ATOM 810 OE1
GLN 98 26.455 47.828 10.589 1.00 52.58 8 ATOM 811 NE2 GLN 98 24.603
49.088 10.563 1.00 53.06 7 ATOM 812 C GLN 98 24.662 47.218 15.172
1.00 31.48 6 ATOM 813 O GLN 98 24.459 47.664 16.300 1.00 27.98 8
ATOM 814 N GLU 99 24.990 45.955 14.920 1.00 30.75 7 ATOM 815 CA GLU
99 25.112 44.978 16.009 1.00 32.56 6 ATOM 816 CB GLU 99 25.598
43.653 15.420 1.00 36.89 6 ATOM 817 CG GLU 99 25.204 42.392 16.141
1.00 44.86 6 ATOM 818 CD GLU 99 24.771 41.288 15.184 1.00 48.45 6
ATOM 819 OE1 GLU 99 23.802 40.573 15.521 1.00 53.90 8 ATOM 820 OE2
GLU 99 25.400 41.148 14.118 1.00 50.56 8 ATOM 821 C GLU 99 26.130
45.551 16.980 1.00 31.14 6 ATOM 822 O GLU 99 27.136 46.048 16.475
1.00 31.94 8 ATOM 823 N GLY 100 25.919 45.571 18.275 1.00 32.19 7
ATOM 824 CA GLY 100 26.874 46.123 19.217 1.00 31.10 6 ATOM 825 C
GLY 100 26.643 47.541 19.696 1.00 31.51 6 ATOM 826 O GLY 100 27.082
47.931 20.789 1.00 30.30 8 ATOM 827 N GLU 101 25.948 48.369 18.921
1.00 34.41 7 ATOM 828 CA GLU 101 25.675 49.746 19.297 1.00 34.07 6
ATOM 829 CB GLU 101 24.949 50.452 18.148 1.00 37.86 6 ATOM 830 CG
GLU 101 25.777 50.676 16.889 1.00 48.38 6 ATOM 831 CD GLU 101
24.984 51.520 15.895 1.00 49.17 6 ATOM 832 OE1 GLU 101 24.251
52.408 16.385 1.00 58.51 8 ATOM 833 OE2 GLU 101 25.046 51.333
14.669 1.00 48.56 8 ATOM 834 C GLU 101 24.783 49.848 20.537 1.00
33.06 6 ATOM 835 O GLU 101 24.086 48.888 20.886 1.00 27.70 8 ATOM
836 N THR 102 24.747 51.057 21.107 1.00 31.92 7 ATOM 837 CA THR 102
23.870 51.303 22.248 1.00 32.85 6 ATOM 838 CB THR 102 24.508 52.161
23.341 1.00 35.75 6 ATOM 839 OG1 THR 102 25.546 51.438 24.021 1.00
36.79 8 ATOM 840 CG2 THR 102 23.532 52.577 24.441 1.00 35.82 6 ATOM
841 C THR 102 22.582 51.944 21.721 1.00 32.54 6 ATOM 842 O THR 102
22.650 52.932 20.991 1.00 30.03 8 ATOM 843 N ILE 103 21.431 51.329
22.014 1.00 28.53 7 ATOM 844 CA ILE 103 20.162 51.939 21.590 1.00
25.40 6 ATOM 845 CB ILE 103 19.131 50.873 21.163 1.00 26.58 6 ATOM
846 CG2 ILE 103 17.776 51.496 20.828 1.00 25.47 6 ATOM 847 CG1 ILE
103 19.669 50.080 19.971 1.00 21.79 6 ATOM 848 CD1 ILE 103 18.739
49.003 19.438 1.00 19.73 6 ATOM 849 C ILE 103 19.624 52.753 22.767
1.00 25.27 6 ATOM 850 O ILE 103 19.439 52.181 23.853 1.00 23.06 8
ATOM 851 N MET 104 19.443 54.059 22.591 1.00 24.90 7 ATOM 852 CA
MET 104 18.893 54.913 23.639 1.00 21.55 6 ATOM 853 CB MET 104
19.797 56.097 23.963 1.00 33.48 6 ATOM 854 CG MET 104 20.810 55.826
25.101 1.00 29.68 6 ATOM 855 SD MET 104 21.940 57.256 25.242 1.00
46.02 16 ATOM 856 CE MET 104 22.667 57.216 23.589 1.00 31.10 6 ATOM
857 C MET 104 17.528 55.456 23.215 1.00 21.27 6 ATOM 858 O MET 104
17.374 55.991 22.106 1.00 22.96 8 ATOM 859 N LEU 105 16.503 55.242
24.027 1.00 20.55 7 ATOM 860 CA LEU 105 15.134 55.668 23.728 1.00
22.33 6 ATOM 861 CB LEU 105 14.192 54.450 23.550 1.00 14.66 6 ATOM
862 CG LEU 105 14.713 53.389 22.561 1.00 18.89 6 ATOM 863 CD1 LEU
105 13.796 52.178 22.489 1.00 19.44 6 ATOM 864 CD2 LEU 105 14.882
54.056 21.186 1.00 18.70 6 ATOM 865 C LEU 105 14.567 56.559 24.817
1.00 20.15 6 ATOM 866 O LEU 105 15.050 56.506 25.950 1.00 18.39 8
ATOM 867 N ARG 106 13.523 57.324 24.483 1.00 18.25 7 ATOM 868 CA
ARG 106 12.912 58.174 25.516 1.00 17.87 6 ATOM 869 CB ARG 106
13.607 59.553 25.508 1.00 14.96 6 ATOM 870 CG ARG 106 12.834 60.597
26.290 1.00 16.79 6 ATOM 871 CD ARG 106 13.699 61.788 26.757 1.00
19.51 6 ATOM 872 NE ARG 106 13.334 62.927 26.025 1.00 23.46 7 ATOM
873 CZ ARG 106 12.990 64.174 26.065 1.00 24.43 6 ATOM 874 NH1 ARG
106 12.923 64.892 27.176 1.00 25.93 7 ATOM 875 NH2 ARG 106 12.697
64.795 24.936 1.00 18.72 7 ATOM 876 C ARG 106 11.422 58.321 25.304
1.00 18.56 6 ATOM 877 O ARG 106 10.998 58.479 24.142 1.00 20.43 8
ATOM 878 N CYS 107 10.642 58.246 26.378 1.00 15.23 7 ATOM 879 CA
CYS 107 9.189 58.419 26.292 1.00 14.89 6 ATOM 880 C CYS 107 8.934
59.891 26.583 1.00 15.28 6 ATOM 881 O CYS 107 9.296 60.294 27.690
1.00 15.96 8 ATOM 882 CB CYS 107 8.438 57.565 27.322 1.00 14.55 6
ATOM 883 SG CYS 107 6.691 57.368 27.013 1.00 13.91 16 ATOM 884 N
HIS 108 8.446 60.653 25.604 1.00 15.07 7 ATOM 885 CA HIS 108 8.334
62.103 25.811 1.00 11.91 6 ATOM 886 CB HIS 108 9.190 62.757 24.708
1.00 16.03 6 ATOM 887 CG HIS 108 9.119 64.240 24.572 1.00 16.94 6
ATOM 888 CD2 HIS 108 9.068 65.023 23.462 1.00 17.64 6 ATOM 889 ND1
HIS 108 9.103 65.108 25.657 1.00 17.41 7 ATOM 890 CE1 HIS 108 9.034
66.350 25.215 1.00 17.37 6 ATOM 891 NE2 HIS 108 9.021 66.333 23.895
1.00 20.00 7 ATOM 892 C HIS 108 6.925 62.647 25.733 1.00 11.83 6
ATOM 893 O HIS 108 6.224 62.361 24.762 1.00 12.54 8 ATOM 894 N SER
109 6.515 63.502 26.654 1.00 13.70 7 ATOM 895 CA SER 109 5.160
64.091 26.605 1.00 11.70 6 ATOM 896 CB SER 109 4.583 64.134 28.041
1.00 13.47 6 ATOM 897 OG SER 109 5.609 64.845 28.800 1.00 16.16 8
ATOM 898 C SER 109 5.190 65.459 25.970 1.00 14.21 6 ATOM 899 O SER
109 6.180 66.232 25.903 1.00 14.63 8 ATOM 900 N TRP 110 4.047
65.804 25.381 1.00 16.58 7 ATOM 901 CA TRP 110 3.860 67.102 24.708
1.00 16.04 6 ATOM 902 CB TRP 110 2.480 67.158 24.072 1.00 18.73 6
ATOM 903 CG TRP 110 2.187 68.425 23.306 1.00 21.24 6 ATOM 904 CD2
TRP 110 1.135 69.339 23.589 1.00 20.70 6 ATOM 905 CE2 TRP 110 1.193
70.361 22.616 1.00 25.92 6 ATOM 906 CE3 TRP 110 0.112 69.372 24.549
1.00 24.16 6 ATOM 907 CD1 TRP 110 2.827 68.908 22.214 1.00 22.22 6
ATOM 908 NE1 TRP 110 2.233 70.069 21.765 1.00 22.81 7 ATOM 909 CZ2
TRP 110 0.276 71.404 22.568 1.00 24.18 6 ATOM 910 CZ3 TRP 110
-0.781 70.434 24.509 1.00
30.15 6 ATOM 911 CH2 TRP 110 -0.698 71.433 23.526 1.00 31.04 6 ATOM
912 C TRP 110 4.082 68.245 25.681 1.00 14.44 6 ATOM 913 O TRP 110
3.665 68.219 26.852 1.00 17.08 8 ATOM 914 N LYS 111 4.928 69.199
25.294 1.00 19.42 7 ATOM 915 CA LYS 111 5.347 70.325 26.115 1.00
19.40 6 ATOM 916 CB LYS 111 4.131 71.241 26.418 1.00 21.00 6 ATOM
917 CG LYS 111 3.583 71.904 25.155 1.00 24.94 6 ATOM 918 CD LYS 111
2.124 72.287 25.337 1.00 34.17 6 ATOM 919 CE LYS 111 1.952 73.719
25.781 1.00 37.49 6 ATOM 920 NZ LYS 111 2.783 74.668 24.987 1.00
52.66 7 ATOM 921 C LYS 111 5.940 69.921 27.450 1.00 20.33 6 ATOM
922 O LYS 111 5.905 70.694 28.419 1.00 16.80 8 ATOM 923 N ASP 112
6.444 68.695 27.602 1.00 18.28 7 ATOM 924 CA ASP 112 6.989 68.233
28.861 1.00 20.31 6 ATOM 925 CB ASP 112 8.242 69.088 29.191 1.00
24.52 6 ATOM 926 CG ASP 112 9.306 68.737 28.155 1.00 31.39 6 ATOM
927 OD1 ASP 112 9.700 67.545 28.119 1.00 39.68 8 ATOM 928 OD2 ASP
112 9.719 69.588 27.360 1.00 35.00 8 ATOM 929 C ASP 112 6.015
68.203 30.018 1.00 23.40 6 ATOM 930 O ASP 112 6.426 68.475 31.148
1.00 23.42 8 ATOM 931 N LYS 113 4.731 67.889 29.785 1.00 23.10 7
ATOM 932 CA LYS 113 3.792 67.721 30.891 1.00 22.35 6 ATOM 933 CB
LYS 113 2.352 67.432 30.437 1.00 21.68 6 ATOM 934 CG LYS 113 1.758
68.611 29.659 1.00 27.09 6 ATOM 935 CD LYS 113 0.232 68.574 29.608
1.00 28.34 6 ATOM 936 CE LYS 113 -0.269 69.780 28.816 1.00 32.92 6
ATOM 937 NZ LYS 113 -0.196 71.075 29.554 1.00 33.55 7 ATOM 938 C
LYS 113 4.352 66.597 31.748 1.00 19.86 6 ATOM 939 O LYS 113 4.890
65.603 31.264 1.00 21.45 8 ATOM 940 N PRO 114 4.288 66.761 33.066
1.00 20.08 7 ATOM 941 CD PRO 114 3.701 67.928 33.768 1.00 16.95 6
ATOM 942 CA PRO 114 4.923 65.801 33.957 1.00 17.00 6 ATOM 943 CB
PRO 114 4.548 66.292 35.342 1.00 19.22 6 ATOM 944 CG PRO 114 4.169
67.733 35.176 1.00 21.34 6 ATOM 945 C PRO 114 4.451 64.405 33.636
1.00 16.83 6 ATOM 946 O PRO 114 3.237 64.125 33.512 1.00 16.01 8
ATOM 947 N LEU 115 5.414 63.483 33.560 1.00 15.95 7 ATOM 948 CA LEU
115 5.081 62.104 33.215 1.00 17.10 6 ATOM 949 CB LEU 115 5.769
61.879 31.856 1.00 16.83 6 ATOM 950 CG LEU 115 5.790 60.498 31.231
1.00 21.64 6 ATOM 951 CD1 LEU 115 4.399 60.132 30.733 1.00 19.24 6
ATOM 952 CD2 LEU 115 6.777 60.486 30.043 1.00 19.80 6 ATOM 953 C
LEU 115 5.606 61.116 34.226 1.00 21.13 6 ATOM 954 O LEU 115 6.788
61.200 34.569 1.00 18.84 8 ATOM 955 N VAL 116 4.839 60.105 34.630
1.00 20.51 7 ATOM 956 CA VAL 116 5.314 59.073 35.545 1.00 20.40 6
ATOM 957 CB VAL 116 4.787 59.277 36.971 1.00 18.72 6 ATOM 958 CG1
VAL 116 5.313 60.547 37.644 1.00 22.67 6 ATOM 959 CG2 VAL 116 3.257
59.328 36.998 1.00 22.12 6 ATOM 960 C VAL 116 4.807 57.703 35.073
1.00 19.73 6 ATOM 961 O VAL 116 3.910 57.682 34.223 1.00 20.76 8
ATOM 962 N LYS 117 5.268 56.615 35.693 1.00 17.34 7 ATOM 963 CA LYS
117 4.760 55.290 35.381 1.00 20.33 6 ATOM 964 CB LYS 117 3.271
55.182 35.802 1.00 21.74 6 ATOM 965 CG LYS 117 3.115 54.927 37.301
1.00 24.43 6 ATOM 966 CD LYS 117 1.793 55.445 37.832 1.00 32.69 6
ATOM 967 CE LYS 117 0.798 54.314 38.056 1.00 40.27 6 ATOM 968 NZ
LYS 117 -0.568 54.865 38.266 1.00 44.06 7 ATOM 969 C LYS 117 4.956
54.936 33.914 1.00 18.58 6 ATOM 970 O LYS 117 4.026 54.535 33.234
1.00 24.35 8 ATOM 971 N VAL 118 6.181 55.063 33.417 1.00 20.45 7
ATOM 972 CA VAL 118 6.542 54.798 32.039 1.00 19.15 6 ATOM 973 CB
VAL 118 7.756 55.643 31.607 1.00 12.17 6 ATOM 974 CG1 VAL 118 8.199
55.396 30.176 1.00 18.94 6 ATOM 975 CG2 VAL 118 7.408 57.129 31.794
1.00 16.75 6 ATOM 976 C VAL 118 6.868 53.330 31.797 1.00 18.58 6
ATOM 977 O VAL 118 7.606 52.717 32.564 1.00 17.16 8 ATOM 978 N THR
119 6.307 52.803 30.711 1.00 15.94 7 ATOM 979 CA THR 119 6.527
51.425 30.335 1.00 16.50 6 ATOM 980 CB THR 119 5.291 50.523 30.367
1.00 19.59 6 ATOM 981 OG1 THR 119 4.770 50.410 31.693 1.00 23.11 8
ATOM 982 CG2 THR 119 5.695 49.123 29.872 1.00 24.83 6 ATOM 983 C
THR 119 7.053 51.424 28.881 1.00 17.81 6 ATOM 984 O THR 119 6.436
52.130 28.095 1.00 14.36 8 ATOM 985 N PHE 120 8.121 50.679 28.643
1.00 14.86 7 ATOM 986 CA PHE 120 8.616 50.608 27.259 1.00 13.85 6
ATOM 987 CB PHE 120 10.122 50.797 27.240 1.00 15.51 6 ATOM 988 CG
PHE 120 10.553 52.230 27.463 1.00 13.38 6 ATOM 989 CD1 PHE 120
10.748 52.701 28.750 1.00 20.15 6 ATOM 990 CD2 PHE 120 10.792
53.051 26.381 1.00 20.08 6 ATOM 991 CE1 PHE 120 11.186 54.002
28.953 1.00 17.14 6 ATOM 992 CE2 PHE 120 11.230 54.367 26.578 1.00
22.12 6 ATOM 993 CZ PHE 120 11.423 54.818 27.867 1.00 17.10 6 ATOM
994 C PHE 120 8.279 49.216 26.721 1.00 17.13 6 ATOM 995 O PHE 120
8.640 48.221 27.407 1.00 14.78 8 ATOM 996 N PHE 121 7.626 49.166
25.575 1.00 16.20 7 ATOM 997 CA PHE 121 7.277 47.868 25.011 1.00
18.83 6 ATOM 998 CB PHE 121 5.799 47.821 24.616 1.00 13.50 6 ATOM
999 CG PHE 121 4.768 48.052 25.656 1.00 18.60 6 ATOM 1000 CD1 PHE
121 4.368 49.339 26.017 1.00 17.37 6 ATOM 1001 CD2 PHE 121 4.208
46.961 26.334 1.00 18.44 6 ATOM 1002 CE1 PHE 121 3.409 49.524
27.006 1.00 19.78 6 ATOM 1003 CE2 PHE 121 3.260 47.173 27.313 1.00
22.69 6 ATOM 1004 CZ PHE 121 2.843 48.445 27.660 1.00 15.74 6 ATOM
1005 C PHE 121 8.074 47.539 23.749 1.00 18.44 6 ATOM 1006 O PHE 121
8.351 48.454 22.987 1.00 15.63 8 ATOM 1007 N GLN 122 8.333 46.253
23.480 1.00 19.35 7 ATOM 1008 CA GLN 122 8.959 45.880 22.203 1.00
19.90 6 ATOM 1009 CB GLN 122 10.396 45.379 22.317 1.00 16.32 6 ATOM
1010 CG GLN 122 10.784 44.583 21.065 1.00 18.39 6 ATOM 1011 CD GLN
122 12.050 43.764 21.247 1.00 21.98 6 ATOM 1012 OE1 GLN 122 12.423
43.461 22.374 1.00 19.18 8 ATOM 1013 NE2 GLN 122 12.700 43.396
20.153 1.00 24.51 7 ATOM 1014 C GLN 122 8.067 44.774 21.609 1.00
15.34 6 ATOM 1015 O GLN 122 7.789 43.832 22.321 1.00 17.30 8 ATOM
1016 N ASN 123 7.474 44.931 20.439 1.00 18.98 7 ATOM 1017 CA ASN
123 6.542 43.975 19.859 1.00 22.95 6 ATOM 1018 CB ASN 123 7.241
42.708 19.332 1.00 19.57 6 ATOM 1019 CG ASN 123 8.228 43.130 18.244
1.00 26.31 6 ATOM 1020 OD1 ASN 123 8.013 44.053 17.441 1.00 19.76 8
ATOM 1021 ND2 ASN 123 9.375 42.463 18.213 1.00 28.57 7 ATOM 1022 C
ASN 123 5.397 43.643 20.803 1.00 21.02 6 ATOM 1023 O ASN 123 4.911
42.525 20.918 1.00 19.19 8 ATOM 1024 N GLY 124 4.951 44.632 21.579
1.00 19.77 7 ATOM 1025 CA GLY 124 3.852 44.516 22.495 1.00 16.41 6
ATOM 1026 C GLY 124 4.159 43.885 23.844 1.00 14.85 6 ATOM 1027 O
GLY 124 3.210 43.658 24.611 1.00 15.05 8 ATOM 1028 N LYS 125 5.405
43.610 24.133 1.00 13.81 7 ATOM 1029 CA LYS 125 5.830 42.997 25.379
1.00 21.18 6 ATOM 1030 CB LYS 125 6.700 41.738 25.247 1.00 14.85 6
ATOM 1031 CG LYS 125 6.934 41.032 26.559 1.00 16.28 6 ATOM 1032 CD
LYS 125 7.406 39.587 26.281 1.00 22.51 6 ATOM 1033 CE LYS 125 7.925
38.989 27.587 1.00 30.62 6 ATOM 1034 NZ LYS 125 8.822 37.818 27.330
1.00 36.72 7 ATOM 1035 C LYS 125 6.725 44.014 26.121 1.00 18.20 6
ATOM 1036 O LYS 125 7.648 44.525 25.509 1.00 19.98 8 ATOM 1037 N
SER 126 6.385 44.216 27.393 1.00 17.62 7 ATOM 1038 CA SER 126 7.107
45.241 28.155 1.00 20.03 6 ATOM 1039 CB SER 126 6.355 45.459 29.485
1.00 23.22 6 ATOM 1040 OG SER 126 7.317 45.773 30.466 1.00 38.12 8
ATOM 1041 C SER 126 8.541 44.823 28.389 1.00 17.85 6 ATOM 1042 O
SER 126 8.842 43.657 28.647 1.00 21.31 8 ATOM 1043 N GLN 127 9.490
45.718 28.254 1.00 17.16 7 ATOM 1044 CA GLN 127 10.898 45.515
28.408 1.00 17.45 6 ATOM 1045 CB GLN 127 11.723 46.073 27.225 1.00
20.82 6 ATOM 1046 CG GLN 127 11.352 45.419 25.897 1.00 18.56 6 ATOM
1047 CD GLN 127 11.497 43.912 25.927 1.00 24.44 6 ATOM 1048 OE1 GLN
127 12.606 43.416 26.116 1.00 31.62 8 ATOM 1049 NE2 GLN 127 10.436
43.130 25.773 1.00 19.15 7 ATOM 1050 C GLN 127 11.386 46.251 29.661
1.00 20.94 6 ATOM 1051 O GLN 127 12.439 45.929 30.179 1.00 18.25 8
ATOM 1052 N LYS 128 10.643 47.285 30.032 1.00 21.18 7 ATOM 1053 CA
LYS 128 11.070 48.048 31.216 1.00 23.10 6 ATOM 1054 CB LYS 128
12.177 49.034 30.842 1.00 21.83 6 ATOM 1055 CG LYS 128 12.683
49.882 32.013 1.00 24.67 6 ATOM 1056 CD LYS 128 13.739 50.905
31.589 1.00 18.23 6 ATOM 1057 CE LYS 128 14.048 51.746 32.870 1.00
27.02 6 ATOM 1058 NZ LYS 128 15.081 52.794 32.574 1.00 24.24 7 ATOM
1059 C LYS 128 9.884 48.844 31.754 1.00 24.93 6 ATOM 1060 O LYS 128
9.193 49.481 30.960 1.00 20.79 8 ATOM 1061 N PHE 129 9.678 48.822
33.062 1.00 21.39 7 ATOM 1062 CA PHE 129 8.708 49.695 33.695 1.00
24.45 6 ATOM 1063 CB PHE 129 7.610 48.926 34.458 1.00 25.50 6 ATOM
1064 CG PHE 129 6.772 49.837 35.327 1.00 25.51 6 ATOM 1065 CD1 PHE
129 5.799 50.630 34.762 1.00 19.40 6 ATOM 1066 CD2 PHE 129 7.002
49.928 36.700 1.00 29.98 6 ATOM 1067 CE1 PHE 129 5.026 51.491
35.535 1.00 25.00 6 ATOM 1068 CE2 PHE 129 6.249 50.788 37.491 1.00
28.84 6 ATOM 1069 CZ PHE 129 5.262 51.574 36.902 1.00 32.29 6 ATOM
1070 C PHE 129 9.480 50.577 34.687 1.00 27.88 6 ATOM 1071 O PHE 129
10.388 50.049 35.359 1.00 30.99 8 ATOM 1072 N SER 130 9.134 51.846
34.853 1.00 26.67 7 ATOM 1073 CA SER 130 9.779 52.641 35.917 1.00
24.98 6 ATOM 1074 CB SER 130 11.025 53.344 35.422 1.00 21.29 6 ATOM
1075 OG SER 130 11.271 54.465 36.250 1.00 25.72 8 ATOM 1076 C SER
130 8.777 53.667 36.434 1.00 24.39 6 ATOM 1077 O SER 130 8.123
54.285 35.576 1.00 24.91 8 ATOM 1078 N HIS 131 8.668 53.889 37.730
1.00 22.12 7 ATOM 1079 CA HIS 131 7.710 54.901 38.204 1.00 23.65 6
ATOM 1080 CB HIS 131 7.604 54.918 39.737 1.00 28.35 6 ATOM 1081 CG
HIS 131 6.859 53.706 40.197 1.00 23.57 6 ATOM 1082 CD2 HIS 131
7.307 52.509 40.642 1.00 18.55 6 ATOM 1083 ND1 HIS 131 5.478 53.666
40.170 1.00 26.69 7 ATOM 1084 CE1 HIS 131 5.095 52.478 40.617 1.00
16.65 6 ATOM 1085 NE2 HIS 131 6.173 51.764 40.890 1.00 23.94 7 ATOM
1086 C HIS 131 8.108 56.314 37.814 1.00 23.89 6 ATOM 1087 O HIS 131
7.261 57.205 37.712 1.00 26.21 8 ATOM 1088 N LEU 132 9.426 56.548
37.689 1.00 21.77 7 ATOM 1089 CA LEU 132 9.886 57.900 37.480 1.00
20.70 6 ATOM 1090 CB LEU 132 10.630 58.361 38.760 1.00 30.28 6 ATOM
1091 CG LEU 132 10.022 58.084 40.148 1.00 26.56 6 ATOM 1092 CD1 LEU
132 11.073 58.316 41.229 1.00 29.07 6 ATOM 1093 CD2 LEU 132 8.814
58.980 40.435 1.00 24.99 6 ATOM 1094 C LEU 132 10.762 58.144 36.279
1.00 22.94 6 ATOM 1095 O LEU 132 10.794 59.326 35.900 1.00 22.01 8
ATOM 1096 N ASP 133 11.541 57.181 35.778 1.00 21.75 7 ATOM 1097 CA
ASP 133 12.469 57.401 34.679 1.00 24.62 6 ATOM 1098 CB ASP 133
13.560 56.327 34.854 1.00 29.71 6 ATOM 1099 CG ASP 133 14.734
56.321 33.915 1.00 32.90 6 ATOM 1100 OD1 ASP 133 14.837 57.254
33.083 1.00 32.91 8 ATOM 1101 OD2 ASP 133 15.597 55.394 34.000 1.00
36.01 8 ATOM 1102 C ASP 133 11.843 57.230 33.296 1.00 25.88 6 ATOM
1103 O ASP 133 11.419 56.136 32.940 1.00 24.36 8 ATOM 1104 N PRO
134 11.857 58.261 32.460 1.00 24.65 7 ATOM 1105 CD PRO 134 12.347
59.620 32.778 1.00 22.97 6 ATOM 1106 CA PRO 134 11.293 58.185
31.112 1.00 24.00 6 ATOM 1107 CB PRO 134 10.889 59.662 30.870 1.00
24.02 6 ATOM 1108 CG PRO 134 11.987 60.433 31.544 1.00 23.04 6 ATOM
1109 C PRO 134 12.256 57.764 30.017 1.00 22.11 6 ATOM 1110 O PRO
134 11.970 57.930 28.824 1.00 19.00 8 ATOM 1111 N THR 135 13.420
57.212 30.350 1.00 21.43 7 ATOM 1112 CA THR 135 14.424 56.805
29.401 1.00 24.98 6 ATOM 1113 CB THR 135 15.748 57.584 29.593 1.00
27.24 6 ATOM 1114 OG1 THR 135 16.331 57.065 30.796 1.00 24.99 8
ATOM 1115 CG2 THR 135 15.461 59.069 29.706 1.00 26.07 6 ATOM 1116 C
THR 135 14.747 55.312 29.451 1.00 23.58 6 ATOM 1117 O THR 135
14.445 54.629 30.423 1.00 26.14 8 ATOM 1118 N PHE 136 15.267 54.790
28.347 1.00 20.63 7 ATOM 1119 CA PHE 136 15.549 53.391 28.150 1.00
20.10 6 ATOM 1120 CB PHE 136 14.343 52.706 27.523 1.00 25.47 6 ATOM
1121 CG PHE 136 14.408 51.250 27.170 1.00 25.61 6 ATOM 1122 CD1 PHE
136 14.528 50.270 28.121 1.00 27.00 6 ATOM 1123 CD2 PHE 136 14.332
50.847 25.841 1.00 27.45 6 ATOM 1124 CE1 PHE 136 14.571 48.929
27.787 1.00 32.62 6 ATOM 1125 CE2 PHE 136 14.385 49.516 25.490 1.00
28.46 6 ATOM 1126 CZ PHE 136 14.493 48.549 26.463 1.00 30.41 6 ATOM
1127 C PHE 136 16.796 53.197 27.297 1.00 24.00 6 ATOM 1128 O PHE
136 16.952 53.801 26.230 1.00 24.50 8 ATOM 1129 N SER 137 17.665
52.294 27.730 1.00 21.97 7 ATOM 1130 CA SER 137 18.914 52.010
27.050 1.00 26.52 6 ATOM 1131 CB SER 137 20.120 52.418 27.908 1.00
30.03 6 ATOM 1132 OG SER 137 20.769 53.559 27.412 1.00 44.19 8 ATOM
1133 C SER 137 19.128 50.507 26.840 1.00 27.38 6 ATOM 1134 O SER
137 18.911 49.694 27.721 1.00 27.33 8 ATOM 1135 N ILE 138 19.654
50.164 25.686 1.00 25.86 7 ATOM 1136 CA ILE 138 20.004 48.806
25.343 1.00 29.46 6 ATOM 1137 CB ILE 138 19.189 48.176 24.193 1.00
33.38 6 ATOM 1138 CG2 ILE 138 19.669 46.748 23.941 1.00 27.23 6
ATOM 1139 CG1 ILE 138 17.679 48.197 24.472 1.00 30.55 6 ATOM 1140
CD1 ILE 138 16.817 48.155 23.223 1.00 29.53 6 ATOM 1141 C ILE 138
21.477 48.875 24.926 1.00 29.88 6 ATOM 1142 O ILE 138 21.768 49.377
23.849 1.00 27.99 8 ATOM 1143 N PRO 139 22.345 48.476 25.837 1.00
31.71 7 ATOM 1144 CD PRO 139 22.018 47.938 27.184 1.00 32.73 6 ATOM
1145 CA PRO 139 23.776 48.398 25.598 1.00 33.85 6 ATOM 1146 CB PRO
139 24.380 48.213 26.983 1.00 36.13 6 ATOM 1147 CG PRO 139 23.248
48.384 27.950 1.00 34.99 6 ATOM 1148 C PRO 139 24.030 47.160 24.741
1.00 35.63 6 ATOM 1149 O PRO 139 23.324 46.160 24.888 1.00 38.22 8
ATOM 1150 N GLN 140 24.974 47.208 23.827 1.00 36.97 7 ATOM 1151 CA
GLN 140 25.288 46.110 22.935 1.00 35.17 6 ATOM 1152 CB GLN 140
26.223 45.124 23.631 1.00 43.87 6 ATOM 1153 CG GLN 140 27.518
45.802 24.088 1.00 49.77 6 ATOM 1154 CD GLN 140 27.883 45.282
25.468 1.00 56.21 6 ATOM 1155 OE1 GLN 140 28.145 44.084 25.593 1.00
57.44 8 ATOM 1156 NE2 GLN 140 27.883 46.161 26.468 1.00 57.25 7
ATOM 1157 C GLN 140 24.060 45.418 22.362 1.00 34.61 6 ATOM 1158 O
GLN 140 23.677 44.284 22.693 1.00 33.34 8 ATOM 1159 N ALA 141
23.473 46.111 21.391 1.00 29.80 7 ATOM 1160 CA ALA 141 22.287
45.634 20.694 1.00 30.02 6 ATOM 1161 CB ALA 141 21.778 46.745
19.774 1.00 27.89 6 ATOM 1162 C ALA 141 22.561 44.400 19.832 1.00
29.52 6 ATOM 1163 O ALA 141 23.650 44.270 19.263 1.00 29.60 8 ATOM
1164 N ASN 142 21.528 43.582 19.665 1.00 30.60 7 ATOM 1165 CA ASN
142 21.642 42.435 18.738 1.00 31.55 6 ATOM 1166 CB ASN 142 21.985
41.139 19.453 1.00 30.39 6 ATOM 1167 CG ASN 142 21.012 40.749
20.534 1.00 31.63 6 ATOM 1168 OD1 ASN 142 19.838 40.423 20.268 1.00
27.57 8 ATOM 1169 ND2 ASN 142 21.479 40.739 21.781 1.00 33.23 7
ATOM 1170 C ASN 142 20.357 42.321 17.936 1.00 32.33 6 ATOM 1171 O
ASN 142 19.453 43.168 18.122 1.00 29.09 8 ATOM 1172 N HIS 143
20.223 41.257 17.134 1.00 29.40 7 ATOM 1173 CA HIS 143 19.075
41.086 16.266 1.00 28.82 6 ATOM 1174 CB HIS 143 19.262 39.895
15.272 1.00 24.51 6 ATOM 1175 CG HIS 143 20.360 40.234 14.295 1.00
31.72 6 ATOM 1176 CD2 HIS 143 20.704 41.420 13.740 1.00 33.88 6
ATOM 1177 ND1 HIS 143 21.278 39.328 13.822 1.00 32.86 7 ATOM 1178
CE1 HIS 143 22.117 39.927 13.008 1.00 31.84 6 ATOM 1179 NE2 HIS 143
21.794 41.202 12.941 1.00 31.48 7 ATOM 1180 C HIS 143 17.747 40.857
16.976 1.00 26.62 6 ATOM 1181 O HIS 143 16.696 41.098 16.366 1.00
25.96 8 ATOM 1182 N SER 144 17.812 40.412 18.221 1.00 20.85 7 ATOM
1183 CA SER 144 16.557 40.128 18.941 1.00 24.82 6 ATOM 1184 CB SER
144 16.839 38.979 19.915 1.00 30.28 6 ATOM 1185 OG SER 144 17.739
39.389 20.930 1.00 39.11 8 ATOM 1186 C SER 144 15.976 41.423 19.474
1.00 24.89 6 ATOM 1187 O SER 144 14.775 41.518 19.755 1.00 25.22 8
ATOM 1188 N HIS 145 16.746 42.522 19.463 1.00 20.33 7 ATOM 1189 CA
HIS 145 16.306 43.861 19.811 1.00 19.38 6 ATOM 1190 CB HIS 145
17.474 44.762 20.302 1.00 19.40 6 ATOM 1191 CG HIS 145 18.145
44.212 21.534 1.00 18.37 6 ATOM 1192 CD2 HIS 145 17.620 43.886
22.744 1.00 18.22 6 ATOM 1193 ND1 HIS 145 19.493 43.965 21.627 1.00
23.55 7 ATOM 1194 CE1 HIS 145 19.768 43.492 22.829 1.00 26.33 6
ATOM 1195 NE2 HIS 145 18.643 43.412 23.525 1.00 21.05 7 ATOM 1196 C
HIS 145 15.589 44.553 18.657 1.00 22.05 6 ATOM 1197 O HIS 145
15.013 45.636 18.848 1.00 21.86 8 ATOM 1198 N SER 146 15.569 43.997
17.440 1.00 20.66 7 ATOM 1199 CA SER 146 14.833 44.649 16.363 1.00
19.96 6 ATOM 1200 CB SER 146 15.075 44.009 14.986 1.00 20.48 6 ATOM
1201 OG SER 146 16.442 44.154 14.613 1.00 25.61 8 ATOM 1202 C SER
146 13.339 44.596 16.656 1.00 20.51 6 ATOM 1203 O SER 146 12.915
43.614 17.287 1.00 22.06 8 ATOM 1204 N GLY 147 12.556 45.578 16.197
1.00 16.70 7 ATOM 1205 CA GLY 147 11.123 45.383 16.411 1.00 20.49 6
ATOM 1206 C GLY 147 10.385 46.714
16.555 1.00 22.63 6 ATOM 1207 O GLY 147 10.982 47.762 16.332 1.00
16.09 8 ATOM 1208 N ASP 148 9.111 46.560 16.951 1.00 20.62 7 ATOM
1209 CA ASP 148 8.324 47.777 17.121 1.00 21.57 6 ATOM 1210 CB ASP
148 6.882 47.579 16.674 1.00 28.99 6 ATOM 1211 CG ASP 148 6.819
47.144 15.219 1.00 41.07 6 ATOM 1212 OD1 ASP 148 7.849 47.338
14.540 1.00 39.21 8 ATOM 1213 OD2 ASP 148 5.763 46.620 14.808 1.00
39.40 8 ATOM 1214 C ASP 148 8.315 48.214 18.590 1.00 20.72 6 ATOM
1215 O ASP 148 7.817 47.469 19.447 1.00 20.27 8 ATOM 1216 N TYR 149
8.822 49.440 18.798 1.00 16.97 7 ATOM 1217 CA TYR 149 8.811 49.966
20.164 1.00 18.60 6 ATOM 1218 CB TYR 149 10.193 50.587 20.472 1.00
16.94 6 ATOM 1219 CG TYR 149 11.272 49.534 20.606 1.00 18.45 6 ATOM
1220 CD1 TYR 149 11.901 48.928 19.528 1.00 19.27 6 ATOM 1221 CE1
TYR 149 12.877 47.948 19.737 1.00 20.18 6 ATOM 1222 CD2 TYR 149
11.672 49.162 21.879 1.00 18.36 6 ATOM 1223 CE2 TYR 149 12.636
48.216 22.116 1.00 15.60 6 ATOM 1224 CZ TYR 149 13.238 47.606
21.027 1.00 18.77 6 ATOM 1225 OH TYR 149 14.211 46.660 21.253 1.00
18.41 8 ATOM 1226 C TYR 149 7.767 51.061 20.355 1.00 15.78 6 ATOM
1227 O TYR 149 7.539 51.859 19.450 1.00 15.86 8 ATOM 1228 N HIS 150
7.196 51.126 21.559 1.00 15.01 7 ATOM 1229 CA HIS 150 6.247 52.171
21.925 1.00 12.99 6 ATOM 1230 CB HIS 150 4.849 51.980 21.372 1.00
11.96 6 ATOM 1231 CG HIS 150 3.942 51.032 22.117 1.00 17.71 6 ATOM
1232 CD2 HIS 150 2.944 51.295 23.004 1.00 16.09 6 ATOM 1233 ND1 HIS
150 3.988 49.660 21.971 1.00 11.60 7 ATOM 1234 CE1 HIS 150 3.058
49.103 22.716 1.00 16.95 6 ATOM 1235 NE2 HIS 150 2.407 50.057
23.370 1.00 19.22 7 ATOM 1236 C HIS 150 6.263 52.270 23.462 1.00
13.37 6 ATOM 1237 O HIS 150 6.922 51.448 24.129 1.00 12.78 8 ATOM
1238 N CYS 151 5.680 53.355 23.957 1.00 14.21 7 ATOM 1239 CA CYS
151 5.670 53.559 25.414 1.00 15.38 6 ATOM 1240 C CYS 151 4.301
53.982 25.880 1.00 16.27 6 ATOM 1241 O CYS 151 3.422 54.404 25.132
1.00 15.15 8 ATOM 1242 CB CYS 151 6.746 54.562 25.856 1.00 16.85 6
ATOM 1243 SG CYS 151 6.581 56.269 25.248 1.00 14.82 16 ATOM 1244 N
THR 152 4.080 53.805 27.186 1.00 17.41 7 ATOM 1245 CA THR 152 2.875
54.223 27.862 1.00 17.27 6 ATOM 1246 CB THR 152 1.899 53.131 28.305
1.00 21.80 6 ATOM 1247 OG1 THR 152 2.527 52.212 29.205 1.00 17.53 8
ATOM 1248 CG2 THR 152 1.356 52.388 27.075 1.00 17.12 6 ATOM 1249 C
THR 152 3.346 54.989 29.127 1.00 19.83 6 ATOM 1250 O THR 152 4.471
54.724 29.600 1.00 16.21 8 ATOM 1251 N GLY 153 2.496 55.913 29.534
1.00 17.84 7 ATOM 1252 CA GLY 153 2.815 56.706 30.731 1.00 20.33 6
ATOM 1253 C GLY 153 1.647 57.605 31.108 1.00 18.60 6 ATOM 1254 O
GLY 153 0.779 57.915 30.293 1.00 19.87 8 ATOM 1255 N ASN 154 1.603
58.000 32.373 1.00 20.99 7 ATOM 1256 CA ASN 154 0.560 58.815 32.959
1.00 20.36 6 ATOM 1257 CB ASN 154 0.512 58.556 34.478 1.00 26.77 6
ATOM 1258 CG ASN 154 -0.800 57.928 34.897 1.00 40.91 6 ATOM 1259
OD1 ASN 154 -1.700 58.580 35.441 1.00 46.67 8 ATOM 1260 ND2 ASN 154
-0.927 56.639 34.633 1.00 40.24 7 ATOM 1261 C ASN 154 0.879 60.300
32.817 1.00 22.51 6 ATOM 1262 O ASN 154 1.973 60.685 33.272 1.00
22.15 8 ATOM 1263 N ILE 155 -0.018 61.067 32.202 1.00 19.40 7 ATOM
1264 CA ILE 155 0.198 62.514 32.139 1.00 22.27 6 ATOM 1265 CB ILE
155 0.210 63.116 30.731 1.00 26.29 6 ATOM 1266 CG2 ILE 155 0.327
64.640 30.831 1.00 23.31 6 ATOM 1267 CG1 ILE 155 1.367 62.544
29.899 1.00 28.16 6 ATOM 1268 CD1 ILE 155 1.371 62.874 28.434 1.00
29.42 6 ATOM 1269 C ILE 155 -0.974 63.089 32.941 1.00 27.67 6 ATOM
1270 O ILE 155 -2.112 62.726 32.639 1.00 24.10 8 ATOM 1271 N GLY
156 -0.732 63.838 34.020 1.00 33.10 7 ATOM 1272 CA GLY 156 -1.942
64.285 34.780 1.00 37.62 6 ATOM 1273 C GLY 156 -2.447 63.053 35.527
1.00 38.80 6 ATOM 1274 O GLY 156 -1.659 62.512 36.299 1.00 43.91 8
ATOM 1275 N TYR 157 -3.655 62.573 35.307 1.00 41.47 7 ATOM 1276 CA
TYR 157 -4.182 61.357 35.894 1.00 43.65 6 ATOM 1277 CB TYR 157
-5.381 61.642 36.832 1.00 51.51 6 ATOM 1278 CG TYR 157 -5.020
62.592 37.961 1.00 57.42 6 ATOM 1279 CD1 TYR 157 -5.523 63.885
37.982 1.00 60.45 6 ATOM 1280 CE1 TYR 157 -5.179 64.765 38.992 1.00
62.57 6 ATOM 1281 CD2 TYR 157 -4.140 62.204 38.963 1.00 61.00 6
ATOM 1282 CE2 TYR 157 -3.788 63.079 39.982 1.00 63.03 6 ATOM 1283
CZ TYR 157 -4.313 64.353 39.986 1.00 63.56 6 ATOM 1284 OH TYR 157
-3.979 65.237 40.984 1.00 66.68 8 ATOM 1285 C TYR 157 -4.676 60.351
34.849 1.00 41.96 6 ATOM 1286 O TYR 157 -5.445 59.420 35.115 1.00
41.33 8 ATOM 1287 N THR 158 -4.298 60.547 33.594 1.00 36.77 7 ATOM
1288 CA THR 158 -4.722 59.693 32.496 1.00 30.71 6 ATOM 1289 CB THR
158 -5.260 60.597 31.364 1.00 30.82 6 ATOM 1290 OG1 THR 158 -6.237
61.471 31.942 1.00 30.47 8 ATOM 1291 CG2 THR 158 -5.851 59.819
30.207 1.00 29.21 6 ATOM 1292 C THR 158 -3.532 58.944 31.912 1.00
25.66 6 ATOM 1293 O THR 158 -2.521 59.609 31.642 1.00 24.50 8 ATOM
1294 N LEU 159 -3.689 57.664 31.609 1.00 21.00 7 ATOM 1295 CA LEU
159 -2.617 56.924 30.960 1.00 21.01 6 ATOM 1296 CB LEU 159 -2.737
55.435 31.284 1.00 26.53 6 ATOM 1297 CG LEU 159 -1.601 54.487
30.958 1.00 27.15 6 ATOM 1298 CD1 LEU 159 -0.323 54.817 31.713 1.00
25.15 6 ATOM 1299 CD2 LEU 159 -1.979 53.036 31.316 1.00 28.75 6
ATOM 1300 C LEU 159 -2.654 57.179 29.461 1.00 22.04 6 ATOM 1301 O
LEU 159 -3.711 57.248 28.844 1.00 22.64 8 ATOM 1302 N PHE 160
-1.484 57.396 28.855 1.00 20.79 7 ATOM 1303 CA PHE 160 -1.430
57.576 27.409 1.00 19.10 6 ATOM 1304 CB PHE 160 -0.821 58.946
27.060 1.00 20.91 6 ATOM 1305 CG PHE 160 -1.848 60.034 27.216 1.00
19.50 6 ATOM 1306 CD1 PHE 160 -1.971 60.676 28.442 1.00 24.86 6
ATOM 1307 CD2 PHE 160 -2.645 60.409 26.156 1.00 21.03 6 ATOM 1308
CE1 PHE 160 -2.903 61.709 28.588 1.00 29.44 6 ATOM 1309 CE2 PHE 160
-3.582 61.421 26.296 1.00 19.89 6 ATOM 1310 CZ PHE 160 -3.704
62.074 27.529 1.00 25.34 6 ATOM 1311 C PHE 160 -0.521 56.513 26.794
1.00 17.36 6 ATOM 1312 O PHE 160 0.346 55.982 27.504 1.00 18.36 8
ATOM 1313 N SER 161 -0.753 56.240 25.521 1.00 17.60 7 ATOM 1314 CA
SER 161 0.087 55.302 24.785 1.00 14.63 6 ATOM 1315 CB SER 161
-0.744 54.150 24.188 1.00 20.14 6 ATOM 1316 OG SER 161 0.115 53.054
23.901 1.00 21.55 8 ATOM 1317 C SER 161 0.662 56.037 23.561 1.00
18.96 6 ATOM 1318 O SER 161 -0.101 56.753 22.894 1.00 19.79 8 ATOM
1319 N SER 162 1.921 55.796 23.232 1.00 16.19 7 ATOM 1320 CA SER
162 2.518 56.404 22.049 1.00 16.74 6 ATOM 1321 CB SER 162 4.029
56.678 22.233 1.00 16.78 6 ATOM 1322 OG SER 162 4.801 55.530 21.900
1.00 21.00 8 ATOM 1323 C SER 162 2.322 55.485 20.845 1.00 18.24 6
ATOM 1324 O SER 162 1.949 54.305 20.987 1.00 16.85 8 ATOM 1325 N
LYS 163 2.535 56.027 19.652 1.00 17.96 7 ATOM 1326 CA LYS 163 2.484
55.203 18.445 1.00 17.36 6 ATOM 1327 CB LYS 163 2.369 55.957 17.133
1.00 20.94 6 ATOM 1328 CG LYS 163 1.228 56.885 16.902 1.00 25.34 6
ATOM 1329 CD LYS 163 -0.128 56.271 16.685 1.00 29.02 6 ATOM 1330 CE
LYS 163 -0.954 57.131 15.721 1.00 42.35 6 ATOM 1331 NZ LYS 163
-0.495 58.558 15.692 1.00 38.14 7 ATOM 1332 C LYS 163 3.821 54.466
18.391 1.00 17.27 6 ATOM 1333 O LYS 163 4.817 54.906 18.978 1.00
16.54 8 ATOM 1334 N PRO 164 3.840 53.348 17.696 1.00 18.39 7 ATOM
1335 CD PRO 164 2.702 52.743 16.952 1.00 20.79 6 ATOM 1336 CA PRO
164 5.060 52.572 17.546 1.00 19.84 6 ATOM 1337 CB PRO 164 4.545
51.177 17.142 1.00 17.33 6 ATOM 1338 CG PRO 164 3.254 51.416 16.475
1.00 21.76 6 ATOM 1339 C PRO 164 6.032 53.169 16.528 1.00 19.62 6
ATOM 1340 O PRO 164 5.723 53.942 15.619 1.00 19.46 8 ATOM 1341 N
VAL 165 7.295 52.833 16.674 1.00 17.22 7 ATOM 1342 CA VAL 165 8.427
53.162 15.841 1.00 20.36 6 ATOM 1343 CB VAL 165 9.405 54.190 16.450
1.00 20.84 6 ATOM 1344 CG1 VAL 165 10.418 54.643 15.404 1.00 20.46
6 ATOM 1345 CG2 VAL 165 8.699 55.475 16.899 1.00 23.72 6 ATOM 1346
C VAL 165 9.173 51.833 15.590 1.00 22.05 6 ATOM 1347 O VAL 165
9.532 51.094 16.499 1.00 22.10 8 ATOM 1348 N THR 166 9.444 51.549
14.320 1.00 24.93 7 ATOM 1349 CA THR 166 10.111 50.317 13.939 1.00
26.07 6 ATOM 1350 CB THR 166 9.631 49.784 12.579 1.00 31.66 6 ATOM
1351 OG1 THR 166 9.737 50.811 11.569 1.00 38.39 8 ATOM 1352 CG2 THR
166 8.180 49.353 12.694 1.00 23.71 6 ATOM 1353 C THR 166 11.611
50.597 13.909 1.00 25.06 6 ATOM 1354 O THR 166 11.985 51.536 13.244
1.00 21.88 8 ATOM 1355 N ILE 167 12.362 49.878 14.714 1.00 21.40 7
ATOM 1356 CA ILE 167 13.784 49.907 14.909 1.00 25.06 6 ATOM 1357 CB
ILE 167 14.088 50.164 16.424 1.00 26.21 6 ATOM 1358 CG2 ILE 167
15.588 50.159 16.673 1.00 26.68 6 ATOM 1359 CG1 ILE 167 13.415
51.472 16.825 1.00 26.56 6 ATOM 1360 CD1 ILE 167 13.946 52.318
17.939 1.00 30.83 6 ATOM 1361 C ILE 167 14.416 48.572 14.501 1.00
24.36 6 ATOM 1362 O ILE 167 14.013 47.482 14.920 1.00 23.36 8 ATOM
1363 N THR 168 15.412 48.591 13.630 1.00 22.83 7 ATOM 1364 CA THR
168 16.083 47.405 13.152 1.00 27.27 6 ATOM 1365 CB THR 168 15.945
47.266 11.622 1.00 31.88 6 ATOM 1366 OG1 THR 168 14.565 47.371
11.277 1.00 32.11 8 ATOM 1367 CG2 THR 168 16.462 45.894 11.179 1.00
34.54 6 ATOM 1368 C THR 168 17.575 47.414 13.501 1.00 28.53 6 ATOM
1369 O THR 168 18.190 48.483 13.508 1.00 32.64 8 ATOM 1370 N VAL
169 18.090 46.260 13.863 1.00 23.55 7 ATOM 1371 CA VAL 169 19.472
46.011 14.163 1.00 27.27 6 ATOM 1372 CB VAL 169 19.728 45.359
15.523 1.00 28.51 6 ATOM 1373 CG1 VAL 169 21.227 45.133 15.757 1.00
26.42 6 ATOM 1374 CG2 VAL 169 19.189 46.160 16.696 1.00 27.97 6
ATOM 1375 C VAL 169 20.011 45.022 13.098 1.00 32.65 6 ATOM 1376 O
VAL 169 19.332 44.056 12.710 1.00 33.21 8 ATOM 1377 N GLN 170
21.245 45.196 12.689 0.01 33.85 7 ATOM 1378 CA GLN 170 21.966
44.390 11.737 0.01 35.75 6 ATOM 1379 CB GLN 170 23.335 44.027
12.362 0.01 36.48 6 ATOM 1380 CG GLN 170 24.465 44.012 11.347 0.01
37.54 6 ATOM 1381 CD GLN 170 25.478 45.110 11.599 0.01 37.91 6 ATOM
1382 OE1 GLN 170 25.142 46.186 12.096 0.01 38.17 8 ATOM 1383 NE2
GLN 170 26.735 44.846 11.257 0.01 38.21 7 ATOM 1384 C GLN 170
21.355 43.088 11.241 0.01 36.70 6 ATOM 1385 O GLN 170 21.049 42.167
11.995 0.01 36.81 8 ATOM 1386 N VAL 171 21.273 42.959 9.919 0.01
37.51 7 ATOM 1387 CA VAL 171 20.781 41.772 9.240 0.01 38.20 6 ATOM
1388 CB VAL 171 19.483 41.208 9.842 0.01 38.61 6 ATOM 1389 CG1 VAL
171 18.334 42.199 9.681 0.01 38.88 6 ATOM 1390 CG2 VAL 171 19.115
39.881 9.180 0.01 38.83 6 ATOM 1391 C VAL 171 20.587 42.048 7.750
0.01 38.42 6 ATOM 1392 O VAL 171 21.420 41.573 6.949 0.01 38.53 8
ATOM 1393 OW0 WAT 201 13.958 68.106 19.930 1.00 18.36 8 ATOM 1394
OW0 WAT 202 13.653 41.241 23.320 1.00 24.59 8 ATOM 1395 OW0 WAT 203
5.895 57.410 18.965 1.00 14.14 8 ATOM 1396 OW0 WAT 204 9.519 72.688
30.514 1.00 42.11 8 ATOM 1397 OW0 WAT 205 8.700 64.454 28.355 1.00
21.65 8 ATOM 1398 OW0 WAT 206 25.548 65.664 7.898 1.00 24.88 8 ATOM
1399 OW0 WAT 207 2.902 52.471 31.897 1.00 19.13 8 ATOM 1400 OW0 WAT
208 14.303 45.256 23.676 1.00 24.28 8 ATOM 1401 OW0 WAT 209 10.371
62.552 29.076 1.00 27.73 8 ATOM 1402 OW0 WAT 210 12.433 66.629
21.505 1.00 14.04 8 ATOM 1403 OW0 WAT 211 5.417 47.499 21.002 1.00
16.89 8 ATOM 1404 OW0 WAT 212 29.599 82.797 11.595 1.00 34.62 8
ATOM 1405 OW0 WAT 213 17.813 70.187 2.648 1.00 16.34 8 ATOM 1406
OW0 WAT 214 6.656 58.315 16.413 1.00 24.31 8 ATOM 1407 OW0 WAT 215
21.191 80.146 5.335 1.00 30.05 8 ATOM 1408 OW0 WAT 216 15.621
66.766 18.319 1.00 18.82 8 ATOM 1409 OW0 WAT 217 6.528 56.410
14.460 1.00 26.68 8 ATOM 1410 OW0 WAT 218 6.213 69.723 22.792 1.00
19.89 8 ATOM 1411 OW0 WAT 219 12.935 67.874 24.109 1.00 29.95 8
ATOM 1412 OW0 WAT 220 -2.277 62.236 20.953 1.00 28.34 8 ATOM 1413
OW0 WAT 221 20.151 71.344 0.183 1.00 21.62 8 ATOM 1414 OW0 WAT 222
27.773 65.203 6.295 1.00 20.74 8 ATOM 1415 OW0 WAT 223 -0.481
58.864 19.811 1.00 24.67 8 ATOM 1416 OW0 WAT 224 17.815 67.914
1.120 1.00 26.99 8 ATOM 1417 OW0 WAT 225 16.604 64.761 25.523 1.00
18.45 8 ATOM 1418 OW0 WAT 226 -0.330 59.580 22.516 1.00 29.01 8
ATOM 1419 OW0 WAT 227 13.324 40.955 17.129 1.00 40.98 8 ATOM 1420
OW0 WAT 228 9.214 41.380 22.450 1.00 41.91 8 ATOM 1421 OW0 WAT 229
20.146 82.270 13.850 1.00 50.03 8 ATOM 1422 OW0 WAT 230 21.707
80.353 12.325 1.00 18.46 8 ATOM 1423 OW0 WAT 231 15.403 67.167
25.599 1.00 21.44 8 ATOM 1424 OW0 WAT 232 12.703 63.258 30.174 1.00
37.28 8 ATOM 1425 OW0 WAT 233 12.479 61.400 39.250 1.00 23.78 8
ATOM 1426 OW0 WAT 234 13.921 59.460 9.106 1.00 40.49 8 ATOM 1427
OW0 WAT 235 7.230 72.381 24.432 1.00 41.81 8 ATOM 1428 OW0 WAT 236
2.989 58.681 19.344 1.00 17.29 8 ATOM 1429 OW0 WAT 237 12.865
75.036 10.180 1.00 47.19 8 ATOM 1430 OW0 WAT 238 2.754 67.991
13.259 1.00 35.75 8 ATOM 1431 OW0 WAT 239 17.416 57.608 26.641 1.00
32.09 8 ATOM 1432 OW0 WAT 240 31.068 75.579 10.888 1.00 20.85 8
ATOM 1433 OW0 WAT 241 17.725 71.985 21.261 1.00 25.43 8 ATOM 1434
OW0 WAT 242 32.760 65.251 6.079 1.00 38.04 8 ATOM 1435 OW0 WAT 243
14.079 72.373 25.218 1.00 20.23 8 ATOM 1436 OW0 WAT 244 16.644
77.936 -2.315 1.00 34.00 8 ATOM 1437 OW0 WAT 245 1.790 62.643
35.518 1.00 30.63 8 ATOM 1438 OW0 WAT 246 10.026 76.840 13.639 1.00
31.10 8 ATOM 1439 OW0 WAT 247 11.096 40.538 24.599 1.00 33.25 8
ATOM 1440 OW0 WAT 248 19.457 73.016 -2.970 1.00 36.88 8 ATOM 1441
OW0 WAT 249 18.578 60.108 26.756 1.00 30.86 8 ATOM 1442 OW0 WAT 250
11.119 78.675 16.190 1.00 37.83 8 ATOM 1443 OW0 WAT 251 2.583
76.687 28.032 1.00 73.18 8 ATOM 1444 OW0 WAT 252 0.243 75.153
22.803 1.00 34.15 8 ATOM 1445 OW0 WAT 253 33.328 82.165 10.255 1.00
23.17 8 ATOM 1446 OW0 WAT 254 22.212 87.081 5.080 1.00 51.41 8 ATOM
1447 OW0 WAT 255 21.393 83.921 11.680 1.00 31.47 8 ATOM 1448 OW0
WAT 256 37.174 72.382 4.349 1.00 36.66 8 ATOM 1449 OW0 WAT 257
23.291 53.950 13.981 1.00 45.02 8 ATOM 1450 OW0 WAT 258 31.521
80.134 5.404 1.00 28.19 8 ATOM 1451 OW0 WAT 259 11.904 78.169 8.209
1.00 61.39 8 ATOM 1452 OW0 WAT 260 7.393 36.160 24.668 1.00 45.96 8
ATOM 1453 OW0 WAT 261 12.356 70.954 23.727 1.00 23.77 8 ATOM 1454
OW0 WAT 262 33.898 69.078 7.353 1.00 32.96 8 ATOM 1455 OW0 WAT 263
28.502 52.764 25.478 1.00 58.40 8 ATOM 1456 OW0 WAT 264 23.414
37.810 18.427 1.00 35.16 8 ATOM 1457 OW0 WAT 265 4.792 74.631
16.778 1.00 44.49 8 ATOM 1458 OW0 WAT 266 28.509 77.721 -1.620 1.00
50.51 8 ATOM 1459 OW0 WAT 267 19.685 68.488 -0.712 1.00 45.74 8
ATOM 1460 OW0 WAT 268 10.899 74.487 23.620 1.00 43.61 8 ATOM 1461
OW0 WAT 269 -1.033 73.720 20.128 1.00 34.52 8 ATOM 1462 OW0 WAT 270
15.215 67.397 0.077 1.00 27.35 8 ATOM 1463 OW0 WAT 271 8.748 79.989
16.508 1.00 51.59 8 ATOM 1464 OW0 WAT 272 22.332 82.314 3.707 1.00
30.25 8 ATOM 1465 OW0 WAT 273 23.373 70.771 17.610 1.00 22.44 8
ATOM 1466 OW0 WAT 274 11.965 67.872 26.359 1.00 26.92 8 ATOM 1467
OW0 WAT 275 35.793 71.146 7.198 1.00 27.19 8 ATOM 1468 OW0 WAT 276
10.333 72.530 25.867 1.00 46.78 8 ATOM 1469 OW0 WAT 277 17.230
69.185 24.852 1.00 26.22 8 ATOM 1470 OW0 WAT 278 17.594 51.432
30.830 1.00 32.58 8 ATOM 1471 OW0 WAT 279 8.561 67.703 32.884 1.00
37.04 8 ATOM 1472 OW0 WAT 280 16.374 71.765 -4.195 1.00 31.45 8
ATOM 1473 OW0 WAT 281 8.995 70.329 24.946 1.00 36.64 8 ATOM 1474
OW0 WAT 282 19.019 47.051 28.676 1.00 48.06 8 ATOM 1475 OW0 WAT 283
20.039 61.350 15.742 1.00 23.23 8 ATOM 1476 OW0 WAT 284 21.308
55.309 20.658 1.00 28.24 8 ATOM 1477 OW0 WAT 285 7.405 70.019 5.261
1.00 41.47 8 ATOM 1478 OW0 WAT 286 23.729 66.066 0.632 1.00 30.27 8
ATOM 1479 OW0 WAT 287 15.826 40.095 23.946 1.00 41.94 8 ATOM 1480
OW0 WAT 288 -0.119 50.371 24.812 0.50 25.93 8 ATOM 1481 OW0 WAT 289
3.397 54.879 42.245 1.00 29.87 8 ATOM 1482 OW0 WAT 290 10.215
53.151 32.270 1.00 43.33 8 ATOM 1483 OW0 WAT 291 8.440 65.109
33.883 1.00 34.09 8 ATOM 1 CB ALA 401 -36.645 32.040 -4.702 1.00
51.37 6 ATOM 2 C ALA 401 -36.199 32.572 -2.285 1.00 42.22 6 ATOM 3
O ALA 401 -36.801 33.374 -1.569 1.00 42.70 8 ATOM 4 N ALA 401
-34.367 32.745 -3.997 1.00 45.74 7 ATOM 5 CA ALA 401 -35.829 32.874
-3.724 1.00 43.68 6 ATOM 6 N PRO 402 -35.903 31.367 -1.817 1.00
40.54 7 ATOM 7 CD PRO 402 -35.149 30.320 -2.533 1.00 38.91 6 ATOM 8
CA PRO 402 -36.172 31.022 -0.425 1.00 38.61 6 ATOM 9 CB PRO 402
-35.765 29.566 -0.322 1.00 39.86 6 ATOM 10 CG PRO 402 -34.790
29.353 -1.426 1.00 41.36 6 ATOM 11 C PRO 402 -35.294 31.935 0.434
1.00 36.70 6 ATOM 12 O PRO 402 -34.188 32.212 -0.042 1.00 32.46 8
ATOM 13 N PRO 403 -35.789 32.370 1.579 1.00 33.82 7 ATOM 14 CD PRO
403 -37.120 32.009 2.110 1.00 35.16 6 ATOM 15 CA PRO 403 -35.069
33.229 2.491
1.00 38.25 6 ATOM 16 CB PRO 403 -35.872 33.227 3.799 1.00 37.39 6
ATOM 17 CG PRO 403 -37.180 32.599 3.486 1.00 37.41 6 ATOM 18 C PRO
403 -33.653 32.730 2.790 1.00 37.48 6 ATOM 19 O PRO 403 -33.393
31.531 2.683 1.00 34.39 8 ATOM 20 N LYS 404 -32.763 33.654 3.173
1.00 37.04 7 ATOM 21 CA LYS 404 -31.399 33.188 3.424 1.00 34.97 6
ATOM 22 CB LYS 404 -30.318 34.202 3.122 1.00 43.98 6 ATOM 23 CG LYS
404 -30.564 35.675 3.278 1.00 47.64 6 ATOM 24 CD LYS 404 -29.775
36.517 2.292 1.00 52.03 6 ATOM 25 CE LYS 404 -28.317 36.123 2.137
1.00 57.56 6 ATOM 26 NZ LYS 404 -27.724 36.613 0.855 1.00 56.40 7
ATOM 27 C LYS 404 -31.243 32.632 4.825 1.00 31.44 6 ATOM 28 O LYS
404 -31.846 33.097 5.784 1.00 29.91 8 ATOM 29 N ALA 405 -30.416
31.586 4.908 1.00 28.75 7 ATOM 30 CA ALA 405 -30.039 31.053 6.218
1.00 27.21 6 ATOM 31 CB ALA 405 -29.155 29.834 6.110 1.00 21.94 6
ATOM 32 C ALA 405 -29.278 32.183 6.923 1.00 26.42 6 ATOM 33 O ALA
405 -28.760 33.072 6.222 1.00 26.10 8 ATOM 34 N VAL 406 -29.231
32.192 8.241 1.00 24.91 7 ATOM 35 CA VAL 406 -28.515 33.234 8.985
1.00 26.95 6 ATOM 36 CB VAL 406 -29.490 34.128 9.770 1.00 29.36 6
ATOM 37 CG1 VAL 406 -28.779 35.140 10.676 1.00 29.86 6 ATOM 38 CG2
VAL 406 -30.434 34.842 8.801 1.00 26.74 6 ATOM 39 C VAL 406 -27.503
32.613 9.942 1.00 28.93 6 ATOM 40 O VAL 406 -27.846 31.872 10.866
1.00 31.46 8 ATOM 41 N LEU 407 -26.233 32.937 9.758 1.00 30.08 7
ATOM 42 CA LEU 407 -25.105 32.483 10.546 1.00 29.33 6 ATOM 43 CB
LEU 407 -23.839 32.520 9.657 1.00 33.18 6 ATOM 44 CG LEU 407
-22.828 31.408 9.960 1.00 34.94 6 ATOM 45 CD1 LEU 407 -22.082
30.990 8.721 1.00 27.55 6 ATOM 46 CD2 LEU 407 -21.887 31.864 11.069
1.00 32.30 6 ATOM 47 C LEU 407 -24.816 33.301 11.794 1.00 29.57 6
ATOM 48 O LEU 407 -24.653 34.515 11.800 1.00 30.04 8 ATOM 49 N LYS
408 -24.768 32.624 12.930 1.00 28.04 7 ATOM 50 CA LYS 408 -24.568
33.174 14.257 1.00 25.12 6 ATOM 51 CB LYS 408 -25.738 32.687 15.132
1.00 33.32 6 ATOM 52 CG LYS 408 -25.777 33.255 16.532 1.00 39.37 6
ATOM 53 CD LYS 408 -25.967 32.268 17.652 1.00 43.84 6 ATOM 54 CE
LYS 408 -27.129 31.305 17.487 1.00 47.78 6 ATOM 55 NZ LYS 408
-27.525 30.691 18.793 1.00 48.98 7 ATOM 56 C LYS 408 -23.233 32.674
14.797 1.00 24.53 6 ATOM 57 O LYS 408 -22.934 31.482 14.739 1.00
25.35 8 ATOM 58 N LEU 409 -22.423 33.556 15.333 1.00 24.78 7 ATOM
59 CA LEU 409 -21.080 33.313 15.843 1.00 22.07 6 ATOM 60 CB LEU 409
-20.189 34.383 15.190 1.00 20.04 6 ATOM 61 CG LEU 409 -18.725
34.503 15.596 1.00 20.57 6 ATOM 62 CD1 LEU 409 -17.980 33.242
15.214 1.00 19.57 6 ATOM 63 CD2 LEU 409 -18.084 35.729 14.903 1.00
23.44 6 ATOM 64 C LEU 409 -21.019 33.451 17.346 1.00 21.01 6 ATOM
65 O LEU 409 -21.424 34.473 17.869 1.00 22.38 8 ATOM 66 N GLU 410
-20.583 32.456 18.118 1.00 22.53 7 ATOM 67 CA GLU 410 -20.480
32.581 19.567 1.00 21.02 6 ATOM 68 CB GLU 410 -21.523 31.684 20.270
1.00 27.36 6 ATOM 69 CGA GLU 410 -22.971 32.088 20.090 0.50 28.21 6
ATOM 70 CGB GLU 410 -22.946 32.209 20.195 0.50 38.29 6 ATOM 71 CDA
GLU 410 -24.047 31.077 20.422 0.50 28.55 6 ATOM 72 CDB GLU 410
-23.100 33.664 20.587 0.50 43.48 6 ATOM 73 OE1 GLU 410 -25.131
31.501 20.907 0.50 26.56 8 ATOM 74 OE1 GLU 410 -22.443 34.095
21.565 0.50 47.24 8 ATOM 75 OE2 GLU 410 -23.888 29.858 20.186 0.50
22.10 8 ATOM 76 OE2 GLU 410 -23.871 34.380 19.908 0.50 46.42 8 ATOM
77 C GLU 410 -19.096 32.138 20.008 1.00 19.76 6 ATOM 78 O GLU 410
-18.701 31.024 19.613 1.00 18.00 8 ATOM 79 N PRO 411 -18.423 32.871
20.888 1.00 19.07 7 ATOM 80 CD PRO 411 -17.058 32.526 21.390 1.00
18.71 6 ATOM 81 CA PRO 411 -18.834 34.204 21.319 1.00 18.84 6 ATOM
82 CB PRO 411 -17.807 34.594 22.365 1.00 17.38 6 ATOM 83 CG PRO 411
-16.560 33.866 21.944 1.00 18.86 6 ATOM 84 C PRO 411 -18.787 35.108
20.090 1.00 20.01 6 ATOM 85 O PRO 411 -18.310 34.654 19.051 1.00
16.22 8 ATOM 86 N PRO 412 -19.232 36.349 20.155 1.00 19.94 7 ATOM
87 CD PRO 412 -19.915 36.918 21.361 1.00 21.08 6 ATOM 88 CA PRO 412
-19.409 37.166 18.976 1.00 20.68 6 ATOM 89 CB PRO 412 -20.455
38.210 19.397 1.00 19.82 6 ATOM 90 CG PRO 412 -20.292 38.299 20.872
1.00 23.59 6 ATOM 91 C PRO 412 -18.179 37.805 18.395 1.00 18.70 6
ATOM 92 O PRO 412 -18.268 38.391 17.318 1.00 19.85 8 ATOM 93 N TRP
413 -17.039 37.697 19.059 1.00 15.64 7 ATOM 94 CA TRP 413 -15.815
38.298 18.561 1.00 17.91 6 ATOM 95 CB TRP 413 -14.688 38.026 19.562
1.00 14.32 6 ATOM 96 CG TRP 413 -15.124 38.117 21.006 1.00 16.77 6
ATOM 97 CD2 TRP 413 -15.633 39.254 21.703 1.00 16.90 6 ATOM 98 CE2
TRP 413 -15.899 38.861 23.032 1.00 16.87 6 ATOM 99 CE3 TRP 413
-15.867 40.587 21.350 1.00 18.03 6 ATOM 100 CD1 TRP 413 -15.106
37.097 21.916 1.00 18.97 6 ATOM 101 NE1 TRP 413 -15.589 37.523
23.137 1.00 11.16 7 ATOM 102 CZ2 TRP 413 -16.405 39.742 23.973 1.00
15.92 6 ATOM 103 CZ3 TRP 413 -16.358 41.457 22.301 1.00 10.59 6
ATOM 104 CH2 TRP 413 -16.645 41.041 23.611 1.00 17.87 6 ATOM 105 C
TRP 413 -15.421 37.833 17.163 1.00 19.47 6 ATOM 106 O TRP 413
-15.283 36.628 16.908 1.00 17.22 8 ATOM 107 N ILE 414 -15.101
38.788 16.275 1.00 16.57 7 ATOM 108 CA ILE 414 -14.666 38.425
14.936 1.00 18.93 6 ATOM 109 CB ILE 414 -15.185 39.343 13.816 1.00
16.07 6 ATOM 110 CG2 ILE 414 -16.720 39.345 13.840 1.00 16.61 6
ATOM 111 CG1 ILE 414 -14.582 40.747 13.972 1.00 21.35 6 ATOM 112
CD1 ILE 414 -15.045 41.716 12.896 1.00 26.28 6 ATOM 113 C ILE 414
-13.144 38.317 14.825 1.00 20.48 6 ATOM 114 O ILE 414 -12.652
37.818 13.817 1.00 19.41 8 ATOM 115 N ASN 415 -12.403 38.779 15.836
1.00 19.46 7 ATOM 116 CA ASN 415 -10.935 38.596 15.778 1.00 18.11 6
ATOM 117 CB ASN 415 -10.161 39.904 15.731 1.00 13.53 6 ATOM 118 CG
ASN 415 -10.591 40.920 16.762 1.00 19.11 6 ATOM 119 OD1 ASN 415
-11.728 40.907 17.227 1.00 13.35 8 ATOM 120 ND2 ASN 415 -9.688
41.833 17.142 1.00 10.11 7 ATOM 121 C ASN 415 -10.632 37.742 17.005
1.00 17.54 6 ATOM 122 O ASN 415 -11.016 38.131 18.111 1.00 15.32 8
ATOM 123 N VAL 416 -10.122 36.535 16.805 1.00 16.86 7 ATOM 124 CA
VAL 416 -9.871 35.593 17.893 1.00 15.77 6 ATOM 125 CB VAL 416
-10.761 34.332 17.748 1.00 16.54 6 ATOM 126 CG1 VAL 416 -12.251
34.725 17.733 1.00 13.42 6 ATOM 127 CG2 VAL 416 -10.490 33.521
16.491 1.00 18.04 6 ATOM 128 C VAL 416 -8.420 35.158 17.921 1.00
19.01 6 ATOM 129 O VAL 416 -7.618 35.485 17.010 1.00 17.12 8 ATOM
130 N LEU 417 -8.022 34.444 18.964 1.00 17.68 7 ATOM 131 CA LEU 417
-6.664 33.904 19.068 1.00 15.11 6 ATOM 132 CB LEU 417 -6.162 34.140
20.522 1.00 20.26 6 ATOM 133 CG LEU 417 -5.873 35.615 20.823 1.00
23.07 6 ATOM 134 CD1 LEU 417 -5.447 35.853 22.253 1.00 17.70 6 ATOM
135 CD2 LEU 417 -4.832 36.152 19.855 1.00 26.74 6 ATOM 136 C LEU
417 -6.563 32.427 18.732 1.00 16.37 6 ATOM 137 O LEU 417 -7.518
31.679 18.961 1.00 18.24 8 ATOM 138 N GLN 418 -5.424 31.935 18.227
1.00 18.55 7 ATOM 139 CA GLN 418 -5.237 30.496 18.032 1.00 19.13 6
ATOM 140 CB GLN 418 -3.790 30.145 17.696 1.00 31.65 6 ATOM 141 CG
GLN 418 -3.510 29.617 16.314 1.00 37.32 6 ATOM 142 CD GLN 418
-2.120 29.964 15.800 1.00 36.92 6 ATOM 143 OE1 GLN 418 -1.953
30.834 14.943 1.00 30.97 8 ATOM 144 NE2 GLN 418 -1.135 29.248
16.333 1.00 31.73 7 ATOM 145 C GLN 418 -5.561 29.789 19.348 1.00
19.43 6 ATOM 146 O GLN 418 -5.194 30.298 20.413 1.00 18.10 8 ATOM
147 N GLU 419 -6.317 28.702 19.232 1.00 19.68 7 ATOM 148 CA GLU 419
-6.727 27.821 20.293 1.00 18.88 6 ATOM 149 CB GLU 419 -5.597 27.525
21.293 1.00 27.39 6 ATOM 150 CG GLU 419 -4.649 26.448 20.714 1.00
30.12 6 ATOM 151 CD GLU 419 -3.558 26.167 21.720 1.00 41.87 6 ATOM
152 OE1 GLU 419 -3.857 25.536 22.758 1.00 48.83 8 ATOM 153 OE2 GLU
419 -2.421 26.594 21.464 1.00 46.61 8 ATOM 154 C GLU 419 -8.004
28.244 20.998 1.00 21.46 6 ATOM 155 O GLU 419 -8.496 27.461 21.815
1.00 26.39 8 ATOM 156 N ASP 420 -8.606 29.360 20.619 1.00 19.91 7
ATOM 157 CA ASP 420 -9.898 29.772 21.114 1.00 20.76 6 ATOM 158 CB
ASP 420 -10.285 31.217 20.726 1.00 13.47 6 ATOM 159 CG ASP 420
-9.587 32.288 21.526 1.00 13.93 6 ATOM 160 OD1 ASP 420 -8.873
32.061 22.534 1.00 17.57 8 ATOM 161 OD2 ASP 420 -9.723 33.461
21.104 1.00 13.79 8 ATOM 162 C ASP 420 -11.002 28.916 20.451 1.00
19.58 6 ATOM 163 O ASP 420 -10.913 28.647 19.262 1.00 17.49 8 ATOM
164 N SER 421 -12.071 28.668 21.174 1.00 17.22 7 ATOM 165 CA SER
421 -13.233 27.937 20.659 1.00 17.62 6 ATOM 166 CBA SER 421 -14.011
27.341 21.844 0.50 17.49 6 ATOM 167 CBB SER 421 -13.981 27.310
21.846 0.50 13.14 6 ATOM 168 OGA SER 421 -14.900 26.350 21.355 0.50
22.95 8 ATOM 169 OGB SER 421 -13.175 26.287 22.416 0.50 6.85 8 ATOM
170 C SER 421 -14.181 28.828 19.873 1.00 18.61 6 ATOM 171 O SER 421
-14.424 29.982 20.265 1.00 21.41 8 ATOM 172 N VAL 422 -14.638
28.354 18.721 1.00 15.80 7 ATOM 173 CA VAL 422 -15.585 29.133
17.910 1.00 17.93 6 ATOM 174 CB VAL 422 -15.052 29.632 16.560 1.00
20.37 6 ATOM 175 CG1 VAL 422 -16.093 30.465 15.804 1.00 17.77 6
ATOM 176 CG2 VAL 422 -13.858 30.566 16.679 1.00 17.26 6 ATOM 177 C
VAL 422 -16.822 28.257 17.665 1.00 19.20 6 ATOM 178 O VAL 422
-16.633 27.097 17.291 1.00 18.52 8 ATOM 179 N THR 423 -18.021
28.759 17.917 1.00 16.32 7 ATOM 180 CA THR 423 -19.249 28.043
17.648 1.00 19.99 6 ATOM 181 CB THR 423 -20.080 27.738 18.911 1.00
22.97 6 ATOM 182 OG1 THR 423 -19.192 27.117 19.850 1.00 18.42 8
ATOM 183 CG2 THR 423 -21.241 26.809 18.614 1.00 16.78 6 ATOM 184 C
THR 423 -20.098 28.850 16.658 1.00 24.68 6 ATOM 185 O THR 423
-20.509 29.986 16.897 1.00 22.59 8 ATOM 186 N LEU 424 -20.257
28.248 15.467 1.00 23.73 7 ATOM 187 CA LEU 424 -21.081 28.815
14.423 1.00 23.11 6 ATOM 188 CB LEU 424 -20.427 28.660 13.046 1.00
20.25 6 ATOM 189 CG LEU 424 -19.053 29.386 12.959 1.00 23.95 6 ATOM
190 CD1 LEU 424 -18.324 29.010 11.681 1.00 20.78 6 ATOM 191 CD2 LEU
424 -19.251 30.881 13.049 1.00 22.74 6 ATOM 192 C LEU 424 -22.444
28.103 14.450 1.00 25.87 6 ATOM 193 O LEU 424 -22.470 26.858 14.537
1.00 24.57 8 ATOM 194 N THR 425 -23.520 28.886 14.367 1.00 20.22 7
ATOM 195 CA THR 425 -24.847 28.266 14.336 1.00 23.21 6 ATOM 196 CB
THR 425 -25.656 28.601 15.597 1.00 27.69 6 ATOM 197 OG1 THR 425
-24.945 28.136 16.755 1.00 26.30 8 ATOM 198 CG2 THR 425 -27.041
27.941 15.590 1.00 28.49 6 ATOM 199 C THR 425 -25.604 28.700 13.075
1.00 22.31 6 ATOM 200 O THR 425 -25.706 29.915 12.819 1.00 23.86 8
ATOM 201 N CYS 426 -26.092 27.732 12.307 1.00 18.68 7 ATOM 202 CA
CYS 426 -26.832 27.978 11.075 1.00 23.20 6 ATOM 203 C CYS 426
-28.345 27.956 11.346 1.00 23.06 6 ATOM 204 O CYS 426 -28.957
26.886 11.556 1.00 23.76 8 ATOM 205 CB CYS 426 -26.509 26.985 9.958
1.00 17.92 6 ATOM 206 SG CYS 426 -27.138 27.508 8.311 1.00 22.25 16
ATOM 207 N GLN 427 -28.929 29.137 11.355 1.00 19.35 7 ATOM 208 CA
GLN 427 -30.332 29.345 11.658 1.00 23.30 6 ATOM 209 CB GLN 427
-30.543 30.657 12.464 1.00 29.78 6 ATOM 210 CG GLN 427 -29.623
30.822 13.672 1.00 31.50 6 ATOM 211 CD GLN 427 -29.927 32.038
14.518 1.00 33.01 6 ATOM 212 OE1 GLN 427 -30.322 33.092 14.032 1.00
38.67 8 ATOM 213 NE2 GLN 427 -29.792 31.971 15.834 1.00 36.36 7
ATOM 214 C GLN 427 -31.169 29.449 10.377 1.00 26.33 6 ATOM 215 O
GLN 427 -30.764 30.010 9.347 1.00 23.15 8 ATOM 216 N GLY 428
-32.363 28.847 10.438 1.00 27.69 7 ATOM 217 CA GLY 428 -33.289
28.847 9.313 1.00 28.02 6 ATOM 218 C GLY 428 -34.022 27.506 9.215
1.00 29.41 6 ATOM 219 O GLY 428 -33.639 26.531 9.862 1.00 28.46 8
ATOM 220 N ALA 429 -35.062 27.445 8.389 1.00 27.48 7 ATOM 221 CA
ALA 429 -35.824 26.226 8.210 1.00 27.39 6 ATOM 222 CB ALA 429
-36.979 26.513 7.239 1.00 25.91 6 ATOM 223 C ALA 429 -34.959 25.136
7.574 1.00 28.27 6 ATOM 224 O ALA 429 -34.315 25.451 6.561 1.00
26.07 8 ATOM 225 N ARG 430 -35.060 23.915 8.064 1.00 23.97 7 ATOM
226 CA ARG 430 -34.303 22.811 7.490 1.00 27.17 6 ATOM 227 CB ARG
430 -33.571 22.043 8.601 1.00 30.34 6 ATOM 228 CG ARG 430 -32.574
22.776 9.460 1.00 34.05 6 ATOM 229 CD ARG 430 -32.365 21.986 10.761
1.00 33.86 6 ATOM 230 NE ARG 430 -32.407 22.964 11.836 1.00 38.60 7
ATOM 231 CZ ARG 430 -32.487 22.784 13.126 1.00 38.08 6 ATOM 232 NH1
ARG 430 -32.567 21.568 13.635 1.00 36.51 7 ATOM 233 NH2 ARG 430
-32.467 23.876 13.879 1.00 46.13 7 ATOM 234 C ARG 430 -35.194
21.718 6.880 1.00 26.70 6 ATOM 235 O ARG 430 -36.399 21.724 7.075
1.00 29.22 8 ATOM 236 N SER 431 -34.573 20.737 6.246 1.00 26.85 7
ATOM 237 CA SER 431 -35.315 19.582 5.738 1.00 26.56 6 ATOM 238 CB
SER 431 -34.682 19.020 4.476 1.00 25.03 6 ATOM 239 OG SER 431
-34.562 19.991 3.477 1.00 27.59 8 ATOM 240 C SER 431 -35.273 18.545
6.861 1.00 26.58 6 ATOM 241 O SER 431 -34.396 18.620 7.739 1.00
23.91 8 ATOM 242 N PRO 432 -36.163 17.558 6.839 1.00 23.48 7 ATOM
243 CD PRO 432 -37.224 17.383 5.842 1.00 22.70 6 ATOM 244 CA PRO
432 -36.176 16.516 7.861 1.00 24.75 6 ATOM 245 CB PRO 432 -37.621
16.036 7.805 1.00 24.34 6 ATOM 246 CG PRO 432 -38.095 16.295 6.414
1.00 23.77 6 ATOM 247 C PRO 432 -35.172 15.417 7.549 1.00 29.23 6
ATOM 248 O PRO 432 -35.472 14.257 7.223 1.00 28.28 8 ATOM 249 N GLU
433 -33.913 15.745 7.709 1.00 29.77 7 ATOM 250 CA GLU 433 -32.725
14.970 7.417 1.00 33.37 6 ATOM 251 CBA GLU 433 -32.177 15.440 6.073
0.50 35.18 6 ATOM 252 CBB GLU 433 -32.123 15.409 6.084 0.50 31.98 6
ATOM 253 CGA GLU 433 -30.795 16.037 5.952 0.50 39.40 6 ATOM 254 CGB
GLU 433 -31.776 16.876 5.954 0.50 34.05 6 ATOM 255 CDA GLU 433
-30.394 16.341 4.521 0.50 46.48 6 ATOM 256 CDB GLU 433 -31.601
17.333 4.517 0.50 34.67 6 ATOM 257 OE1 GLU 433 -29.268 16.010 4.076
0.50 49.23 8 ATOM 258 OE1 GLU 433 -32.194 16.698 3.619 0.50 32.81 8
ATOM 259 OE2 GLU 433 -31.232 16.914 3.788 0.50 47.50 8 ATOM 260 OE2
GLU 433 -30.877 18.324 4.275 0.50 24.64 8 ATOM 261 C GLU 433
-31.683 15.177 8.519 1.00 32.61 6 ATOM 262 O GLU 433 -31.612 16.266
9.085 1.00 28.72 8 ATOM 263 N SER 434 -30.844 14.184 8.743 1.00
32.15 7 ATOM 264 CA SER 434 -29.804 14.275 9.764 1.00 32.72 6 ATOM
265 CB SER 434 -29.277 12.853 10.037 1.00 34.26 6 ATOM 266 OG SER
434 -28.320 12.935 11.093 1.00 45.88 8 ATOM 267 C SER 434 -28.668
15.192 9.332 1.00 30.93 6 ATOM 268 O SER 434 -28.156 15.983 10.124
1.00 28.87 8 ATOM 269 N ASP 435 -28.222 15.093 8.082 1.00 28.02 7
ATOM 270 CA ASP 435 -27.167 16.008 7.599 1.00 28.62 6 ATOM 271 CB
ASP 435 -26.292 15.328 6.585 1.00 29.65 6 ATOM 272 CG ASP 435
-25.357 14.227 7.057 1.00 37.43 6 ATOM 273 OD1 ASP 435 -25.027
14.097 8.258 1.00 33.53 8 ATOM 274 OD2 ASP 435 -24.902 13.470 6.154
1.00 36.01 8 ATOM 275 C ASP 435 -27.882 17.223 6.973 1.00 27.08 6
ATOM 276 O ASP 435 -27.997 17.300 5.756 1.00 28.07 8 ATOM 277 N SER
436 -28.461 18.118 7.774 1.00 25.55 7 ATOM 278 CA SER 436 -29.282
19.186 7.225 1.00 27.45 6 ATOM 279 CB SER 436 -30.440 19.435 8.213
1.00 34.87 6 ATOM 280 OG SER 436 -29.973 20.064 9.405 1.00 39.51 8
ATOM 281 C SER 436 -28.558 20.484 6.890 1.00 27.14 6 ATOM 282 O SER
436 -29.143 21.445 6.363 1.00 25.67 8 ATOM 283 N ILE 437 -27.293
20.643 7.231 1.00 24.64 7 ATOM 284 CA ILE 437 -26.580 21.893 6.977
1.00 24.33 6 ATOM 285 CB ILE 437 -26.164 22.559 8.309 1.00 30.71 6
ATOM 286 CG2 ILE 437 -25.561 23.935 8.032 1.00 26.94 6 ATOM 287 CG1
ILE 437 -27.333 22.645 9.308 1.00 21.66 6 ATOM 288 CD1 ILE 437
-28.443 23.588 8.867 1.00 27.66 6 ATOM 289 C ILE 437 -25.336 21.707
6.128 1.00 24.08 6 ATOM 290 O ILE 437 -24.515 20.833 6.390 1.00
23.50 8 ATOM 291 N GLN 438 -25.122 22.552 5.127 1.00 24.52 7 ATOM
292 CA GLN 438 -23.862 22.570 4.399 1.00 23.13 6 ATOM 293 CB GLN
438 -24.016 22.798 2.905 1.00 29.28 6 ATOM 294 CG GLN 438 -24.458
21.570 2.123 1.00 29.86 6 ATOM 295 CD GLN 438 -24.692 21.901 0.661
1.00 33.48 6 ATOM 296 OE1 GLN 438 -25.540 22.744 0.323 1.00 28.34 8
ATOM 297 NE2 GLN 438 -23.922 21.198 -0.177 1.00 38.54 7 ATOM 298 C
GLN 438 -23.048 23.738 4.985 1.00 23.81 6 ATOM 299 O GLN 438
-23.598 24.844 5.087 1.00 22.62 8 ATOM 300 N TRP 439 -21.807 23.480
5.371 1.00 21.43 7 ATOM 301 CA TRP 439 -20.987 24.562 5.905 1.00
21.73 6 ATOM 302 CB TRP 439 -20.345 24.233 7.257 1.00 21.01 6 ATOM
303 CG TRP 439 -21.264 24.233 8.430 1.00 17.58 6 ATOM 304 CD2 TRP
439 -21.721 25.343 9.212 1.00 17.00 6 ATOM 305 CE2 TRP 439 -22.569
24.833 10.220 1.00 16.71 6 ATOM 306 CE3 TRP 439 -21.495 26.719
9.158 1.00 21.47 6 ATOM 307 CD1 TRP 439 -21.844 23.116 8.974 1.00
19.92 6 ATOM 308 NE1 TRP 439 -22.626 23.466 10.061 1.00 22.18 7
ATOM 309 CZ2 TRP 439 -23.218 25.646 11.152 1.00 18.29 6 ATOM 310
CZ3 TRP 439 -22.109 27.537 10.091
1.00 21.62 6 ATOM 311 CH2 TRP 439 -22.960 26.992 11.064 1.00 20.15
6 ATOM 312 C TRP 439 -19.890 24.873 4.898 1.00 22.76 6 ATOM 313 O
TRP 439 -19.407 23.941 4.238 1.00 23.42 8 ATOM 314 N PHE 440
-19.533 26.165 4.758 1.00 22.91 7 ATOM 315 CA PHE 440 -18.512
26.477 3.754 1.00 26.86 6 ATOM 316 CB PHE 440 -19.121 27.144 2.513
1.00 24.16 6 ATOM 317 CG PHE 440 -20.225 26.437 1.788 1.00 23.96 6
ATOM 318 CD1 PHE 440 -21.551 26.586 2.189 1.00 23.61 6 ATOM 319 CD2
PHE 440 -19.945 25.622 0.696 1.00 22.47 6 ATOM 320 CE1 PHE 440
-22.564 25.947 1.504 1.00 20.83 6 ATOM 321 CE2 PHE 440 -20.967
24.986 0.020 1.00 21.69 6 ATOM 322 CZ PHE 440 -22.267 25.126 0.432
1.00 21.86 6 ATOM 323 C PHE 440 -17.466 27.431 4.349 1.00 23.51 6
ATOM 324 O PHE 440 -17.838 28.278 5.151 1.00 21.94 8 ATOM 325 N HIS
441 -16.232 27.291 3.905 1.00 21.59 7 ATOM 326 CA HIS 441 -15.107
28.095 4.366 1.00 24.07 6 ATOM 327 CB HIS 441 -14.032 27.294 5.099
1.00 18.72 6 ATOM 328 CG HIS 441 -12.864 28.139 5.548 1.00 23.41 6
ATOM 329 CD2 HIS 441 -12.794 29.451 5.899 1.00 21.85 6 ATOM 330 ND1
HIS 441 -11.588 27.648 5.709 1.00 21.97 7 ATOM 331 CE1 HIS 441
-10.789 28.607 6.135 1.00 22.79 6 ATOM 332 NE2 HIS 441 -11.504
29.705 6.268 1.00 21.87 7 ATOM 333 C HIS 441 -14.455 28.703 3.115
1.00 21.83 6 ATOM 334 O HIS 441 -13.972 27.947 2.282 1.00 21.37 8
ATOM 335 N ASN 442 -14.576 30.019 2.959 1.00 22.08 7 ATOM 336 CA
ASN 442 -14.077 30.670 1.726 1.00 20.46 6 ATOM 337 CB ASN 442
-12.562 30.544 1.722 1.00 18.21 6 ATOM 338 CG ASN 442 -11.925
31.469 2.761 1.00 22.74 6 ATOM 339 OD1 ASN 442 -12.473 32.523 3.087
1.00 24.40 8 ATOM 340 ND2 ASN 442 -10.804 31.062 3.341 1.00 18.43 7
ATOM 341 C ASN 442 -14.733 30.055 0.488 1.00 21.32 6 ATOM 342 O ASN
442 -14.085 29.819 -0.533 1.00 20.13 8 ATOM 343 N GLY 443 -16.002
29.646 0.568 1.00 20.53 7 ATOM 344 CA GLY 443 -16.767 29.005 -0.480
1.00 20.83 6 ATOM 345 C GLY 443 -16.586 27.506 -0.661 1.00 24.51 6
ATOM 346 O GLY 443 -17.209 26.879 -1.550 1.00 25.30 8 ATOM 347 N
ASN 444 -15.633 26.896 0.051 1.00 21.27 7 ATOM 348 CA ASN 444
-15.391 25.473 -0.112 1.00 20.46 6 ATOM 349 CB ASN 444 -13.903
25.132 0.000 1.00 23.82 6 ATOM 350 CG ASN 444 -13.049 26.032 -0.891
1.00 22.26 6 ATOM 351 OD1 ASN 444 -12.148 26.722 -0.409 1.00 25.47
8 ATOM 352 ND2 ASN 444 -13.382 26.079 -2.171 1.00 21.59 7 ATOM 353
C ASN 444 -16.208 24.723 0.937 1.00 19.78 6 ATOM 354 O ASN 444
-16.180 25.088 2.107 1.00 22.07 8 ATOM 355 N LEU 445 -16.907 23.678
0.523 1.00 22.22 7 ATOM 356 CA LEU 445 -17.730 22.904 1.459 1.00
21.67 6 ATOM 357 CB LEU 445 -18.391 21.725 0.715 1.00 28.15 6 ATOM
358 CG LEU 445 -19.159 20.695 1.538 1.00 29.14 6 ATOM 359 CD1 LEU
445 -20.479 21.295 2.002 1.00 25.07 6 ATOM 360 CD2 LEU 445 -19.452
19.400 0.775 1.00 28.51 6 ATOM 361 C LEU 445 -16.825 22.307 2.525
1.00 22.27 6 ATOM 362 O LEU 445 -15.748 21.869 2.118 1.00 20.13 8
ATOM 363 N ILE 446 -17.263 22.262 3.766 1.00 20.11 7 ATOM 364 CA
ILE 446 -16.539 21.544 4.835 1.00 24.64 6 ATOM 365 CB ILE 446
-16.657 22.358 6.132 1.00 22.24 6 ATOM 366 CG2 ILE 446 -16.007
21.732 7.358 1.00 21.33 6 ATOM 367 CG1 ILE 446 -16.111 23.794 5.945
1.00 20.74 6 ATOM 368 CD1 ILE 446 -16.664 24.719 7.024 1.00 20.48 6
ATOM 369 C ILE 446 -17.351 20.241 5.006 1.00 25.53 6 ATOM 370 O ILE
446 -18.419 20.266 5.624 1.00 22.91 8 ATOM 371 N PRO 447 -16.937
19.119 4.444 1.00 30.56 7 ATOM 372 CD PRO 447 -15.704 18.982 3.620
1.00 32.61 6 ATOM 373 CA PRO 447 -17.731 17.898 4.434 1.00 30.93 6
ATOM 374 CB PRO 447 -17.030 17.030 3.363 1.00 31.28 6 ATOM 375 CG
PRO 447 -15.610 17.466 3.441 1.00 32.54 6 ATOM 376 C PRO 447
-17.888 17.104 5.706 1.00 28.32 6 ATOM 377 O PRO 447 -18.733 16.196
5.747 1.00 29.24 8 ATOM 378 N THR 448 -17.092 17.353 6.730 1.00
26.79 7 ATOM 379 CA THR 448 -17.135 16.568 7.971 1.00 26.97 6 ATOM
380 CB THR 448 -15.698 16.543 8.532 1.00 31.78 6 ATOM 381 OG1 THR
448 -15.241 17.908 8.520 1.00 31.45 8 ATOM 382 CG2 THR 448 -14.798
15.716 7.605 1.00 27.40 6 ATOM 383 C THR 448 -18.075 17.109 9.021
1.00 26.31 6 ATOM 384 O THR 448 -18.206 16.532 10.113 1.00 28.00 8
ATOM 385 N HIS 449 -18.698 18.264 8.772 1.00 24.44 7 ATOM 386 CA
HIS 449 -19.612 18.924 9.707 1.00 24.19 6 ATOM 387 CB HIS 449
-18.953 20.256 10.174 1.00 25.11 6 ATOM 388 CG HIS 449 -17.722
19.927 10.961 1.00 22.20 6 ATOM 389 CD2 HIS 449 -16.430 19.757
10.624 1.00 27.86 6 ATOM 390 ND1 HIS 449 -17.809 19.641 12.306 1.00
29.80 7 ATOM 391 CE1 HIS 449 -16.595 19.340 12.762 1.00 28.91 6
ATOM 392 NE2 HIS 449 -15.748 19.392 11.761 1.00 25.35 7 ATOM 393 C
HIS 449 -20.923 19.278 9.041 1.00 23.08 6 ATOM 394 O HIS 449
-20.942 20.061 8.075 1.00 20.57 8 ATOM 395 N THR 450 -22.038 18.704
9.497 1.00 25.11 7 ATOM 396 CA THR 450 -23.321 18.892 8.807 1.00
22.98 6 ATOM 397 CB THR 450 -23.732 17.552 8.137 1.00 23.01 6 ATOM
398 OG1 THR 450 -23.843 16.614 9.231 1.00 18.66 8 ATOM 399 CG2 THR
450 -22.757 17.049 7.101 1.00 19.07 6 ATOM 400 C THR 450 -24.460
19.221 9.766 1.00 24.61 6 ATOM 401 O THR 450 -25.640 19.094 9.393
1.00 26.17 8 ATOM 402 N GLN 451 -24.126 19.592 10.985 1.00 24.52 7
ATOM 403 CA GLN 451 -25.132 19.887 11.995 1.00 27.31 6 ATOM 404 CB
GLN 451 -24.708 19.361 13.378 1.00 28.63 6 ATOM 405 CG GLN 451
-24.438 17.852 13.378 1.00 32.81 6 ATOM 406 CD GLN 451 -25.677
17.056 12.995 1.00 38.53 6 ATOM 407 OE1 GLN 451 -26.606 16.914
13.802 1.00 37.60 8 ATOM 408 NE2 GLN 451 -25.724 16.535 11.765 1.00
32.79 7 ATOM 409 C GLN 451 -25.411 21.379 12.101 1.00 26.69 6 ATOM
410 O GLN 451 -24.626 22.230 11.689 1.00 26.27 8 ATOM 411 N PRO 452
-26.510 21.728 12.769 1.00 25.16 7 ATOM 412 CD PRO 452 -27.553
20.775 13.270 1.00 24.54 6 ATOM 413 CA PRO 452 -26.917 23.103
12.974 1.00 25.24 6 ATOM 414 CB PRO 452 -28.264 22.978 13.708 1.00
26.09 6 ATOM 415 CG PRO 452 -28.804 21.649 13.257 1.00 23.35 6 ATOM
416 C PRO 452 -25.900 23.951 13.722 1.00 25.71 6 ATOM 417 O PRO 452
-25.877 25.179 13.542 1.00 21.61 8 ATOM 418 N SER 453 -25.044
23.369 14.556 1.00 24.05 7 ATOM 419 CA SER 453 -23.991 24.093
15.239 1.00 25.63 6 ATOM 420 CB SER 453 -24.105 24.155 16.758 1.00
31.86 6 ATOM 421 OG SER 453 -24.778 25.371 17.094 1.00 42.46 8 ATOM
422 C SER 453 -22.681 23.406 14.854 1.00 24.85 6 ATOM 423 O SER 453
-22.681 22.193 14.691 1.00 23.68 8 ATOM 424 N TYR 454 -21.658
24.177 14.614 1.00 24.52 7 ATOM 425 CA TYR 454 -20.333 23.699
14.212 1.00 26.29 6 ATOM 426 CB TYR 454 -20.050 23.980 12.729 1.00
26.92 6 ATOM 427 CG TYR 454 -18.612 23.868 12.274 1.00 30.15 6 ATOM
428 CD1 TYR 454 -17.719 22.961 12.825 1.00 29.18 6 ATOM 429 CE1 TYR
454 -16.407 22.860 12.409 1.00 31.26 6 ATOM 430 CD2 TYR 454 -18.104
24.700 11.280 1.00 31.67 6 ATOM 431 CE2 TYR 454 -16.796 24.649
10.855 1.00 31.66 6 ATOM 432 CZ TYR 454 -15.950 23.715 11.429 1.00
33.63 6 ATOM 433 OH TYR 454 -14.624 23.647 11.038 1.00 34.53 8 ATOM
434 C TYR 454 -19.378 24.416 15.167 1.00 24.84 6 ATOM 435 O TYR 454
-19.300 25.656 15.129 1.00 22.53 8 ATOM 436 N ARG 455 -18.773
23.685 16.070 1.00 21.66 7 ATOM 437 CA ARG 455 -17.864 24.216
17.070 1.00 23.60 6 ATOM 438 CB ARG 455 -18.242 23.709 18.480 1.00
25.95 6 ATOM 439 CG ARG 455 -17.478 24.526 19.551 1.00 23.98 6 ATOM
440 CD ARG 455 -17.651 23.884 20.918 1.00 35.38 6 ATOM 441 NE ARG
455 -16.821 24.501 21.956 1.00 27.47 7 ATOM 442 CZ ARG 455 -17.278
25.336 22.879 1.00 33.10 6 ATOM 443 NH1 ARG 455 -18.570 25.657
22.904 1.00 30.00 7 ATOM 444 NH2 ARG 455 -16.418 25.817 23.778 1.00
32.66 7 ATOM 445 C ARG 455 -16.434 23.763 16.802 1.00 27.49 6 ATOM
446 O ARG 455 -16.275 22.554 16.569 1.00 22.62 8 ATOM 447 N PHE 456
-15.455 24.692 16.781 1.00 23.78 7 ATOM 448 CA PHE 456 -14.092
24.230 16.510 1.00 21.92 6 ATOM 449 CB PHE 456 -13.716 24.371
15.036 1.00 25.99 6 ATOM 450 CG PHE 456 -13.819 25.735 14.386 1.00
20.84 6 ATOM 451 CD1 PHE 456 -15.019 26.213 13.897 1.00 21.33 6
ATOM 452 CD2 PHE 456 -12.705 26.547 14.264 1.00 20.31 6 ATOM 453
CE1 PHE 456 -15.103 27.451 13.283 1.00 21.52 6 ATOM 454 CE2 PHE 456
-12.768 27.789 13.680 1.00 18.36 6 ATOM 455 CZ PHE 456 -13.973
28.250 13.159 1.00 18.38 6 ATOM 456 C PHE 456 -13.095 25.004 17.372
1.00 23.93 6 ATOM 457 O PHE 456 -13.454 26.033 17.921 1.00 22.42 8
ATOM 458 N LYS 457 -11.865 24.526 17.423 1.00 22.46 7 ATOM 459 CA
LYS 457 -10.735 25.207 18.054 1.00 24.34 6 ATOM 460 CBA LYS 457
-9.892 24.246 18.881 0.50 28.51 6 ATOM 461 CBB LYS 457 -9.822
24.139 18.669 0.50 22.87 6 ATOM 462 CGA LYS 457 -10.656 23.568
20.010 0.50 33.64 6 ATOM 463 CGB LYS 457 -8.769 24.658 19.632 0.50
24.29 6 ATOM 464 CDA LYS 457 -11.436 24.524 20.892 0.50 40.75 6
ATOM 465 CDB LYS 457 -8.631 23.680 20.798 0.50 26.90 6 ATOM 466 CEA
LYS 457 -12.612 23.876 21.603 0.50 43.07 6 ATOM 467 CEB LYS 457
-9.138 24.262 22.092 0.50 29.79 6 ATOM 468 NZA LYS 457 -12.703
24.236 23.044 0.50 51.71 7 ATOM 469 NZB LYS 457 -8.050 24.601
23.060 0.50 36.22 7 ATOM 470 C LYS 457 -9.950 25.943 16.969 1.00
21.30 6 ATOM 471 O LYS 457 -9.436 25.315 16.052 1.00 19.46 8 ATOM
472 N ALA 458 -9.928 27.278 16.945 1.00 18.23 7 ATOM 473 CA ALA 458
-9.341 28.002 15.821 1.00 15.74 6 ATOM 474 CB ALA 458 -9.612 29.505
16.094 1.00 9.09 6 ATOM 475 C ALA 458 -7.841 27.832 15.614 1.00
20.26 6 ATOM 476 O ALA 458 -7.067 27.802 16.574 1.00 18.04 8 ATOM
477 N ASN 459 -7.392 27.740 14.367 1.00 18.31 7 ATOM 478 CA ASN 459
-5.986 27.795 14.019 1.00 23.04 6 ATOM 479 CB ASN 459 -5.222 26.565
13.612 1.00 32.39 6 ATOM 480 CG ASN 459 -5.880 25.223 13.665 1.00
38.26 6 ATOM 481 OD1 ASN 459 -5.855 24.587 14.716 1.00 42.50 8 ATOM
482 ND2 ASN 459 -6.426 24.800 12.529 1.00 43.39 7 ATOM 483 C ASN
459 -5.825 28.814 12.867 1.00 24.07 6 ATOM 484 O ASN 459 -6.794
29.390 12.365 1.00 21.25 8 ATOM 485 N ASN 460 -4.582 29.033 12.484
1.00 24.40 7 ATOM 486 CA ASN 460 -4.192 30.043 11.519 1.00 31.47 6
ATOM 487 CB ASN 460 -2.680 29.973 11.234 1.00 31.46 6 ATOM 488 CGA
ASN 460 -2.272 31.090 10.274 0.50 31.26 6 ATOM 489 CGB ASN 460
-2.221 28.594 10.814 0.50 35.72 6 ATOM 490 OD1 ASN 460 -2.337
32.284 10.597 0.50 22.52 8 ATOM 491 OD1 ASN 460 -2.985 27.626
10.768 0.50 33.04 8 ATOM 492 ND2 ASN 460 -1.863 30.691 9.070 0.50
26.04 7 ATOM 493 ND2 ASN 460 -0.932 28.475 10.483 0.50 39.47 7 ATOM
494 C ASN 460 -5.006 29.923 10.234 1.00 29.05 6 ATOM 495 O ASN 460
-5.645 30.880 9.780 1.00 32.27 8 ATOM 496 N ASN 461 -5.098 28.713
9.710 1.00 30.20 7 ATOM 497 CAA ASN 461 -5.863 28.379 8.529 0.50
28.68 6 ATOM 498 CAB ASN 461 -5.857 28.499 8.477 0.50 29.13 6 ATOM
499 CBA ASN 461 -5.564 26.911 8.150 0.50 26.19 6 ATOM 500 CBB ASN
461 -5.403 27.195 7.806 0.50 30.25 6 ATOM 501 CGA ASN 461 -4.101
26.739 7.792 0.50 27.01 6 ATOM 502 CGB ASN 461 -5.608 25.984 8.678
0.50 32.36 6 ATOM 503 OD1 ASN 461 -3.502 25.741 8.184 0.50 28.58 8
ATOM 504 OD1 ASN 461 -6.383 26.046 9.637 0.50 33.38 8 ATOM 505 ND2
ASN 461 -3.526 27.694 7.071 0.50 34.39 7 ATOM 506 ND2 ASN 461
-4.927 24.875 8.384 0.50 33.52 7 ATOM 507 C ASN 461 -7.371 28.530
8.628 1.00 25.33 6 ATOM 508 O ASN 461 -8.030 28.331 7.617 1.00
21.46 8 ATOM 509 N ASP 462 -7.932 28.888 9.767 1.00 24.89 7 ATOM
510 CA ASP 462 -9.373 29.024 9.941 1.00 21.37 6 ATOM 511 CB ASP 462
-9.749 28.582 11.372 1.00 16.89 6 ATOM 512 CG ASP 462 -9.620 27.084
11.538 1.00 26.20 6 ATOM 513 OD1 ASP 462 -9.824 26.317 10.570 1.00
20.81 8 ATOM 514 OD2 ASP 462 -9.276 26.593 12.611 1.00 17.90 8 ATOM
515 C ASP 462 -9.887 30.427 9.645 1.00 18.69 6 ATOM 516 O ASP 462
-11.104 30.657 9.654 1.00 20.50 8 ATOM 517 N SER 463 -9.011 31.389
9.394 1.00 19.81 7 ATOM 518 CA SER 463 -9.434 32.734 9.015 1.00
19.84 6 ATOM 519 CB SER 463 -8.268 33.702 8.811 1.00 22.04 6 ATOM
520 OG SER 463 -7.506 33.848 10.009 1.00 20.02 8 ATOM 521 C SER 463
-10.196 32.662 7.682 1.00 23.89 6 ATOM 522 O SER 463 -10.015 31.706
6.911 1.00 17.92 8 ATOM 523 N GLY 464 -11.056 33.671 7.467 1.00
19.50 7 ATOM 524 CA GLY 464 -11.769 33.675 6.190 1.00 22.23 6 ATOM
525 C GLY 464 -13.272 33.901 6.340 1.00 19.81 6 ATOM 526 O GLY 464
-13.744 34.302 7.399 1.00 18.93 8 ATOM 527 N GLU 465 -13.980 33.640
5.238 1.00 17.01 7 ATOM 528 CA GLU 465 -15.428 33.853 5.269 1.00
21.39 6 ATOM 529 CBA GLU 465 -15.934 34.304 3.901 0.50 13.64 6 ATOM
530 CBB GLU 465 -15.933 34.420 3.947 0.50 23.81 6 ATOM 531 CGA GLU
465 -16.507 35.708 3.813 0.50 15.71 6 ATOM 532 CGB GLU 465 -15.409
35.807 3.602 0.50 32.15 6 ATOM 533 CDA GLU 465 -16.656 36.187 2.381
0.50 22.33 6 ATOM 534 CDB GLU 465 -15.898 36.901 4.520 0.50 40.56 6
ATOM 535 OE1 GLU 465 -17.428 35.603 1.586 0.50 22.70 8 ATOM 536 OE1
GLU 465 -16.578 36.595 5.525 0.50 41.83 8 ATOM 537 OE2 GLU 465
-15.991 37.180 2.014 0.50 31.04 8 ATOM 538 OE2 GLU 465 -15.624
38.108 4.278 0.50 46.02 8 ATOM 539 C GLU 465 -16.155 32.542 5.593
1.00 21.56 6 ATOM 540 O GLU 465 -15.756 31.541 5.007 1.00 21.41 8
ATOM 541 N TYR 466 -17.172 32.598 6.458 1.00 21.38 7 ATOM 542 CA
TYR 466 -17.966 31.383 6.691 1.00 17.91 6 ATOM 543 CB TYR 466
-17.954 30.882 8.129 1.00 17.39 6 ATOM 544 CG TYR 466 -16.620
30.303 8.534 1.00 18.08 6 ATOM 545 CD1 TYR 466 -15.605 31.180 8.957
1.00 18.56 6 ATOM 546 CE1 TYR 466 -14.369 30.719 9.323 1.00 16.48 6
ATOM 547 CD2 TYR 466 -16.348 28.945 8.485 1.00 18.23 6 ATOM 548 CE2
TYR 466 -15.102 28.484 8.867 1.00 18.37 6 ATOM 549 CZ TYR 466
-14.124 29.350 9.279 1.00 18.98 6 ATOM 550 OH TYR 466 -12.872
28.927 9.624 1.00 14.14 8 ATOM 551 C TYR 466 -19.379 31.635 6.212
1.00 13.96 6 ATOM 552 O TYR 466 -19.923 32.731 6.353 1.00 18.14 8
ATOM 553 N THR 467 -20.010 30.638 5.568 1.00 17.95 7 ATOM 554 CA
THR 467 -21.374 30.728 5.117 1.00 18.06 6 ATOM 555 CB THR 467
-21.514 31.022 3.599 1.00 22.52 6 ATOM 556 OG1 THR 467 -20.669
30.129 2.835 1.00 16.85 8 ATOM 557 CG2 THR 467 -21.215 32.495 3.309
1.00 17.46 6 ATOM 558 C THR 467 -22.044 29.358 5.384 1.00 18.76 6
ATOM 559 O THR 467 -21.354 28.351 5.567 1.00 17.47 8 ATOM 560 N CYS
468 -23.354 29.326 5.389 1.00 19.74 7 ATOM 561 CA CYS 468 -24.099
28.074 5.597 1.00 23.50 6 ATOM 562 C CYS 468 -25.382 28.107 4.758
1.00 23.12 6 ATOM 563 O CYS 468 -25.791 29.154 4.279 1.00 25.07 8
ATOM 564 CB CYS 468 -24.434 27.784 7.055 1.00 18.70 6 ATOM 565 SG
CYS 468 -25.675 28.881 7.798 1.00 23.45 16 ATOM 566 N GLN 469
-25.975 26.946 4.534 1.00 24.47 7 ATOM 567 CA GLN 469 -27.174
26.745 3.770 1.00 24.99 6 ATOM 568 CB GLN 469 -26.909 26.522 2.264
1.00 27.22 6 ATOM 569 CG GLN 469 -28.155 26.809 1.419 1.00 25.14 6
ATOM 570 CD GLN 469 -27.857 26.844 -0.065 1.00 32.43 6 ATOM 571 OE1
GLN 469 -26.710 26.700 -0.487 1.00 31.34 8 ATOM 572 NE2 GLN 469
-28.896 27.052 -0.874 1.00 27.89 7 ATOM 573 C GLN 469 -27.901
25.483 4.266 1.00 27.60 6 ATOM 574 O GLN 469 -27.289 24.514 4.734
1.00 25.37 8 ATOM 575 N THR 470 -29.206 25.548 4.115 1.00 28.73 7
ATOM 576 CA THR 470 -30.059 24.401 4.439 1.00 32.10 6 ATOM 577 CB
THR 470 -31.125 24.713 5.491 1.00 33.36 6 ATOM 578 OG1 THR 470
-30.619 25.555 6.553 1.00 45.26 8 ATOM 579 CG2 THR 470 -31.453
23.422 6.210 1.00 50.20 6 ATOM 580 C THR 470 -30.737 23.976 3.138
1.00 32.77 6 ATOM 581 O THR 470 -30.680 24.696 2.130 1.00 30.75 8
ATOM 582 N GLY 471 -31.472 22.859 3.175 1.00 31.83 7 ATOM 583 CA
GLY 471 -32.224 22.397 2.033 1.00 27.97 6 ATOM 584 C GLY 471
-33.376 23.322 1.690 1.00 29.94 6 ATOM 585 O GLY 471 -33.938 23.198
0.596 1.00 32.37 8 ATOM 586 N GLN 472 -33.842 24.159 2.594 1.00
24.86 7 ATOM 587 CA GLN 472 -34.920 25.087 2.457 1.00 27.14 6 ATOM
588 CB GLN 472 -35.868 24.892 3.667 1.00 27.31 6 ATOM 589 CG GLN
472 -36.291 23.415 3.825 1.00 30.51 6 ATOM 590 CD GLN 472 -36.961
22.871 2.567 1.00 30.53 6 ATOM 591 OE1 GLN 472 -37.981 23.425 2.161
1.00 39.95 8 ATOM 592 NE2 GLN 472 -36.402 21.852 1.944 1.00 31.16 7
ATOM 593 C GLN 472 -34.530 26.561 2.441 1.00 29.60 6 ATOM 594 O GLN
472 -35.419 27.424 2.578 1.00 30.82 8 ATOM 595 N THR 473 -33.248
26.912 2.380 1.00 25.83 7 ATOM 596 CA THR 473 -32.861 28.317 2.426
1.00 26.62 6 ATOM 597 CB THR 473 -32.278 28.731 3.792 1.00 26.64 6
ATOM 598 OG1 THR 473 -31.226 27.815 4.138 1.00 27.54 8 ATOM 599 CG2
THR 473 -33.313 28.742 4.897 1.00 28.16 6 ATOM 600 C THR 473
-31.824 28.643 1.371 1.00 26.31 6 ATOM 601 O THR 473 -31.210 27.756
0.776 1.00 28.00 8 ATOM 602 N SER 474 -31.685 29.939 1.074 1.00
28.62 7 ATOM 603 CA SER 474 -30.592 30.261 0.112 1.00 29.44 6 ATOM
604 CB SER 474 -31.020 31.396 -0.803 1.00 30.45 6 ATOM 605 OG SER
474 -31.407 32.467 0.034 1.00 41.05 8 ATOM 606 C SER 474 -29.366
30.471 0.992
1.00 26.65 6 ATOM 607 O SER 474 -29.461 30.428 2.228 1.00 25.57 8
ATOM 608 N LEU 475 -28.178 30.585 0.442 1.00 29.47 7 ATOM 609 CA
LEU 475 -26.915 30.703 1.158 1.00 25.10 6 ATOM 610 CB LEU 475
-25.749 30.725 0.159 1.00 27.83 6 ATOM 611 CG LEU 475 -24.348
30.730 0.777 1.00 27.24 6 ATOM 612 CD1 LEU 475 -23.888 29.312 1.094
1.00 24.13 6 ATOM 613 CD2 LEU 475 -23.349 31.446 -0.133 1.00 24.42
6 ATOM 614 C LEU 475 -26.884 31.893 2.087 1.00 25.84 6 ATOM 615 O
LEU 475 -27.300 33.008 1.711 1.00 22.45 8 ATOM 616 N SER 476
-26.376 31.708 3.315 1.00 23.31 7 ATOM 617 CA SER 476 -26.357
32.857 4.219 1.00 25.20 6 ATOM 618 CB SER 476 -25.916 32.464 5.644
1.00 26.64 6 ATOM 619 OG SER 476 -24.514 32.203 5.624 1.00 29.43 8
ATOM 620 C SER 476 -25.346 33.911 3.738 1.00 23.00 6 ATOM 621 O SER
476 -24.431 33.562 3.006 1.00 21.02 8 ATOM 622 N ASP 477 -25.506
35.127 4.241 1.00 22.24 7 ATOM 623 CA ASP 477 -24.493 36.154 4.094
1.00 26.03 6 ATOM 624 CB ASP 477 -24.907 37.504 4.683 1.00 20.27 6
ATOM 625 CG ASP 477 -25.914 38.190 3.758 1.00 25.73 6 ATOM 626 OD1
ASP 477 -25.821 37.973 2.541 1.00 23.79 8 ATOM 627 OD2 ASP 477
-26.769 38.912 4.292 1.00 28.92 8 ATOM 628 C ASP 477 -23.267 35.675
4.929 1.00 25.85 6 ATOM 629 O ASP 477 -23.423 34.962 5.914 1.00
24.00 8 ATOM 630 N PRO 478 -22.098 36.108 4.492 1.00 27.37 7 ATOM
631 CD PRO 478 -21.917 36.949 3.275 1.00 26.84 6 ATOM 632 CA PRO
478 -20.849 35.736 5.098 1.00 25.42 6 ATOM 633 CB PRO 478 -19.795
36.274 4.141 1.00 28.38 6 ATOM 634 CG PRO 478 -20.453 37.280 3.272
1.00 27.24 6 ATOM 635 C PRO 478 -20.575 36.310 6.479 1.00 25.28 6
ATOM 636 O PRO 478 -21.006 37.407 6.820 1.00 23.68 8 ATOM 637 N VAL
479 -19.833 35.535 7.265 1.00 20.24 7 ATOM 638 CA VAL 479 -19.287
36.005 8.535 1.00 18.86 6 ATOM 639 CB VAL 479 -19.850 35.350 9.783
1.00 19.49 6 ATOM 640 CG1 VAL 479 -19.042 35.627 11.046 1.00 22.25
6 ATOM 641 CG2 VAL 479 -21.275 35.907 10.036 1.00 21.95 6 ATOM 642
C VAL 479 -17.777 35.820 8.399 1.00 19.76 6 ATOM 643 O VAL 479
-17.283 34.736 8.076 1.00 22.34 8 ATOM 644 N HIS 480 -17.024 36.911
8.566 1.00 19.43 7 ATOM 645 CA HIS 480 -15.584 36.890 8.387 1.00
18.11 6 ATOM 646 CB HIS 480 -15.130 38.245 7.784 1.00 26.87 6 ATOM
647 CG HIS 480 -13.712 38.112 7.293 1.00 31.93 6 ATOM 648 CD2 HIS
480 -13.194 37.883 6.069 1.00 27.05 6 ATOM 649 ND1 HIS 480 -12.637
38.169 8.176 1.00 34.35 7 ATOM 650 CE1 HIS 480 -11.525 38.019 7.480
1.00 34.80 6 ATOM 651 NE2 HIS 480 -11.831 37.850 6.210 1.00 34.81 7
ATOM 652 C HIS 480 -14.865 36.679 9.718 1.00 23.08 6 ATOM 653 O HIS
480 -15.096 37.370 10.709 1.00 23.37 8 ATOM 654 N LEU 481 -13.953
35.728 9.747 1.00 19.18 7 ATOM 655 CA LEU 481 -13.244 35.388 10.957
1.00 21.58 6 ATOM 656 CB LEU 481 -13.567 33.929 11.331 1.00 18.20 6
ATOM 657 CG LEU 481 -12.847 33.485 12.605 1.00 18.21 6 ATOM 658 CD1
LEU 481 -13.496 34.158 13.812 1.00 19.39 6 ATOM 659 CD2 LEU 481
-12.865 31.954 12.696 1.00 14.76 6 ATOM 660 C LEU 481 -11.747
35.611 10.783 1.00 19.36 6 ATOM 661 O LEU 481 -11.225 35.323 9.720
1.00 20.96 8 ATOM 662 N THR 482 -11.100 36.177 11.793 1.00 19.61 7
ATOM 663 CA THR 482 -9.642 36.403 11.680 1.00 18.45 6 ATOM 664 CB
THR 482 -9.316 37.916 11.683 1.00 25.98 6 ATOM 665 OG1 THR 482
-9.907 38.515 10.527 1.00 18.89 8 ATOM 666 CG2 THR 482 -7.795
38.091 11.666 1.00 24.98 6 ATOM 667 C THR 482 -8.971 35.766 12.891
1.00 16.02 6 ATOM 668 O THR 482 -9.248 36.131 14.035 1.00 14.79 8
ATOM 669 N VAL 483 -8.075 34.821 12.647 1.00 16.23 7 ATOM 670 CA
VAL 483 -7.451 34.108 13.753 1.00 16.97 6 ATOM 671 CB VAL 483
-7.559 32.584 13.530 1.00 12.81 6 ATOM 672 CG1 VAL 483 -7.051
31.894 14.799 1.00 15.92 6 ATOM 673 CG2 VAL 483 -8.986 32.106
13.246 1.00 11.78 6 ATOM 674 C VAL 483 -6.020 34.602 13.892 1.00
19.97 6 ATOM 675 O VAL 483 -5.261 34.537 12.918 1.00 18.57 8 ATOM
676 N LEU 484 -5.686 35.110 15.075 1.00 16.89 7 ATOM 677 CA LEU 484
-4.372 35.678 15.312 1.00 19.89 6 ATOM 678 CB LEU 484 -4.621 37.080
15.890 1.00 18.15 6 ATOM 679 CG LEU 484 -5.491 38.003 15.021 1.00
23.40 6 ATOM 680 CD1 LEU 484 -5.927 39.176 15.868 1.00 25.20 6 ATOM
681 CD2 LEU 484 -4.752 38.470 13.758 1.00 20.46 6 ATOM 682 C LEU
484 -3.487 34.850 16.228 1.00 22.29 6 ATOM 683 O LEU 484 -3.928
33.975 16.975 1.00 23.90 8 ATOM 684 N PHE 485 -2.189 35.116 16.218
1.00 21.03 7 ATOM 685 CA PHE 485 -1.254 34.422 17.111 1.00 22.92 6
ATOM 686 CB PHE 485 -0.399 33.435 16.333 1.00 21.76 6 ATOM 687 CG
PHE 485 0.440 32.516 17.184 1.00 27.90 6 ATOM 688 CD1 PHE 485
-0.103 31.853 18.266 1.00 28.30 6 ATOM 689 CD2 PHE 485 1.787 32.333
16.899 1.00 26.61 6 ATOM 690 CE1 PHE 485 0.664 30.992 19.040 1.00
29.65 6 ATOM 691 CE2 PHE 485 2.559 31.480 17.668 1.00 25.61 6 ATOM
692 CZ PHE 485 1.996 30.819 18.733 1.00 28.75 6 ATOM 693 C PHE 485
-0.455 35.467 17.852 1.00 21.99 6 ATOM 694 O PHE 485 0.642 35.866
17.426 1.00 22.11 8 ATOM 695 N GLU 486 -1.023 35.983 18.938 1.00
20.76 7 ATOM 696 CA GLU 486 -0.421 37.104 19.702 1.00 18.04 6 ATOM
697 CB GLU 486 -1.142 38.403 19.210 1.00 20.84 6 ATOM 698 CG GLU
486 -0.711 39.051 17.911 1.00 25.05 6 ATOM 699 CD GLU 486 -1.647
39.818 17.019 1.00 41.96 6 ATOM 700 OE1 GLU 486 -2.719 40.359
17.416 1.00 46.14 8 ATOM 701 OE2 GLU 486 -1.429 39.973 15.765 1.00
40.77 8 ATOM 702 C GLU 486 -0.694 36.840 21.176 1.00 18.46 6 ATOM
703 O GLU 486 -1.588 36.027 21.462 1.00 16.67 8 ATOM 704 N TRP 487
-0.031 37.458 22.156 1.00 12.60 7 ATOM 705 CA TRP 487 -0.328 37.235
23.553 1.00 13.01 6 ATOM 706 CB TRP 487 0.808 37.810 24.411 1.00
18.40 6 ATOM 707 CG TRP 487 1.922 36.843 24.687 1.00 21.87 6 ATOM
708 CD2 TRP 487 1.812 35.690 25.521 1.00 21.14 6 ATOM 709 CE2 TRP
487 3.065 35.061 25.526 1.00 24.31 6 ATOM 710 CE3 TRP 487 0.767
35.128 26.255 1.00 24.84 6 ATOM 711 CD1 TRP 487 3.216 36.881 24.231
1.00 22.52 6 ATOM 712 NE1 TRP 487 3.907 35.797 24.734 1.00 22.53 7
ATOM 713 CZ2 TRP 487 3.303 33.900 26.266 1.00 29.91 6 ATOM 714 CZ3
TRP 487 0.998 33.976 26.987 1.00 29.83 6 ATOM 715 CH2 TRP 487 2.254
33.367 26.970 1.00 29.09 6 ATOM 716 C TRP 487 -1.599 37.899 24.068
1.00 15.44 6 ATOM 717 O TRP 487 -2.178 37.367 25.018 1.00 16.68 8
ATOM 718 N LEU 488 -2.036 38.993 23.447 1.00 14.44 7 ATOM 719 CA
LEU 488 -3.153 39.815 23.861 1.00 20.07 6 ATOM 720 CB LEU 488
-2.596 40.924 24.783 1.00 17.49 6 ATOM 721 CG LEU 488 -3.608 41.563
25.769 1.00 16.97 6 ATOM 722 CD1 LEU 488 -4.062 40.567 26.830 1.00
17.38 6 ATOM 723 CD2 LEU 488 -2.987 42.813 26.370 1.00 13.93 6 ATOM
724 C LEU 488 -3.889 40.467 22.677 1.00 20.44 6 ATOM 725 O LEU 488
-3.255 41.009 21.752 1.00 19.65 8 ATOM 726 N VAL 489 -5.218 40.349
22.620 1.00 18.11 7 ATOM 727 CA VAL 489 -5.998 40.940 21.542 1.00
14.66 6 ATOM 728 CBA VAL 489 -6.686 39.837 20.699 0.50 7.52 6 ATOM
729 CBB VAL 489 -6.677 39.925 20.604 0.50 13.86 6 ATOM 730 CG1 VAL
489 -7.573 38.976 21.597 0.50 7.13 6 ATOM 731 CG1 VAL 489 -5.696
39.457 19.543 0.50 15.87 6 ATOM 732 CG2 VAL 489 -7.501 40.380
19.531 0.50 3.91 6 ATOM 733 CG2 VAL 489 -7.264 38.776 21.402 0.50
18.65 6 ATOM 734 C VAL 489 -7.109 41.834 22.107 1.00 15.71 6 ATOM
735 O VAL 489 -7.689 41.604 23.179 1.00 14.52 8 ATOM 736 N LEU 490
-7.379 42.908 21.386 1.00 15.13 7 ATOM 737 CA LEU 490 -8.520 43.733
21.703 1.00 13.72 6 ATOM 738 CB LEU 490 -8.287 45.241 21.488 1.00
17.87 6 ATOM 739 CG LEU 490 -9.650 45.888 21.873 1.00 26.07 6 ATOM
740 CD1 LEU 490 -9.479 46.800 23.036 1.00 30.57 6 ATOM 741 CD2 LEU
490 -10.373 46.403 20.662 1.00 25.07 6 ATOM 742 C LEU 490 -9.657
43.192 20.803 1.00 17.58 6 ATOM 743 O LEU 490 -9.611 43.349 19.576
1.00 14.46 8 ATOM 744 N GLN 491 -10.673 42.568 21.412 1.00 15.83 7
ATOM 745 CA GLN 491 -11.745 41.958 20.623 1.00 17.70 6 ATOM 746 CB
GLN 491 -12.252 40.628 21.264 1.00 15.03 6 ATOM 747 CG GLN 491
-11.105 39.635 21.472 1.00 12.81 6 ATOM 748 CD GLN 491 -11.564
38.230 21.868 1.00 15.79 6 ATOM 749 OE1 GLN 491 -12.023 38.043
22.988 1.00 14.61 8 ATOM 750 NE2 GLN 491 -11.409 37.256 20.984 1.00
16.27 7 ATOM 751 C GLN 491 -12.971 42.824 20.375 1.00 17.71 6 ATOM
752 O GLN 491 -13.370 43.570 21.268 1.00 19.37 8 ATOM 753 N THR 492
-13.607 42.659 19.218 1.00 14.05 7 ATOM 754 CA THR 492 -14.853
43.378 18.934 1.00 19.01 6 ATOM 755 CB THR 492 -14.562 44.641
18.089 1.00 16.40 6 ATOM 756 OG1 THR 492 -15.769 45.381 17.905 1.00
18.39 8 ATOM 757 CG2 THR 492 -13.943 44.367 16.720 1.00 10.45 6
ATOM 758 C THR 492 -15.803 42.450 18.173 1.00 18.96 6 ATOM 759 O
THR 492 -15.339 41.594 17.409 1.00 21.88 8 ATOM 760 N PRO 493
-17.095 42.713 18.251 1.00 18.78 7 ATOM 761 CD PRO 493 -17.747
43.697 19.135 1.00 22.16 6 ATOM 762 CA PRO 493 -18.090 41.937
17.530 1.00 24.37 6 ATOM 763 CB PRO 493 -19.352 42.063 18.371 1.00
24.99 6 ATOM 764 CG PRO 493 -19.162 43.257 19.235 1.00 26.05 6 ATOM
765 C PRO 493 -18.285 42.504 16.138 1.00 27.02 6 ATOM 766 O PRO 493
-18.852 41.847 15.248 1.00 27.04 8 ATOM 767 N HIS 494 -17.978
43.797 15.960 1.00 24.22 7 ATOM 768 CA HIS 494 -18.114 44.445
14.651 1.00 25.72 6 ATOM 769 CB HIS 494 -19.444 45.176 14.439 1.00
20.09 6 ATOM 770 CG HIS 494 -20.639 44.279 14.595 1.00 21.67 6 ATOM
771 CD2 HIS 494 -21.161 43.336 13.798 1.00 23.30 6 ATOM 772 ND1 HIS
494 -21.380 44.271 15.754 1.00 27.49 7 ATOM 773 CE1 HIS 494 -22.338
43.365 15.657 1.00 26.54 6 ATOM 774 NE2 HIS 494 -22.211 42.788
14.482 1.00 32.10 7 ATOM 775 C HIS 494 -17.038 45.516 14.453 1.00
24.49 6 ATOM 776 O HIS 494 -16.481 46.028 15.429 1.00 24.01 8 ATOM
777 N LEU 495 -16.847 45.937 13.214 1.00 21.96 7 ATOM 778 CA LEU
495 -15.900 47.019 12.960 1.00 26.06 6 ATOM 779 CB LEU 495 -15.014
46.748 11.741 1.00 26.66 6 ATOM 780 CG LEU 495 -13.994 45.618
11.899 1.00 35.19 6 ATOM 781 CD1 LEU 495 -13.449 45.265 10.525 1.00
25.66 6 ATOM 782 CD2 LEU 495 -12.895 45.958 12.900 1.00 24.13 6
ATOM 783 C LEU 495 -16.626 48.341 12.720 1.00 26.30 6 ATOM 784 O
LEU 495 -15.999 49.402 12.790 1.00 26.83 8 ATOM 785 N GLU 496
-17.884 48.265 12.326 1.00 25.44 7 ATOM 786 CA GLU 496 -18.688
49.453 12.087 1.00 28.55 6 ATOM 787 CB GLU 496 -19.062 49.722
10.634 1.00 28.97 6 ATOM 788 CG GLU 496 -17.977 49.532 9.605 1.00
34.46 6 ATOM 789 CD GLU 496 -18.414 49.757 8.168 1.00 42.07 6 ATOM
790 OE1 GLU 496 -19.560 50.157 7.882 1.00 41.53 8 ATOM 791 OE2 GLU
496 -17.592 49.523 7.256 1.00 45.31 8 ATOM 792 C GLU 496 -19.995
49.291 12.885 1.00 32.22 6 ATOM 793 O GLU 496 -20.525 48.180 13.015
1.00 31.68 8 ATOM 794 N PHE 497 -20.396 50.379 13.538 1.00 29.38 7
ATOM 795 CA PHE 497 -21.622 50.419 14.315 1.00 31.45 6 ATOM 796 CB
PHE 497 -21.388 50.515 15.832 1.00 29.88 6 ATOM 797 CG PHE 497
-20.640 49.369 16.464 1.00 28.91 6 ATOM 798 CD1 PHE 497 -19.256
49.286 16.386 1.00 19.88 6 ATOM 799 CD2 PHE 497 -21.311 48.363
17.131 1.00 27.06 6 ATOM 800 CE1 PHE 497 -18.557 48.242 16.971 1.00
23.29 6 ATOM 801 CE2 PHE 497 -20.622 47.321 17.719 1.00 23.27 6
ATOM 802 CZ PHE 497 -19.244 47.240 17.636 1.00 25.87 6 ATOM 803 C
PHE 497 -22.455 51.633 13.861 1.00 31.11 6 ATOM 804 O PHE 497
-22.007 52.532 13.164 1.00 32.31 8 ATOM 805 N GLN 498 -23.726
51.653 14.219 1.00 34.14 7 ATOM 806 CA GLN 498 -24.636 52.735
13.939 1.00 33.31 6 ATOM 807 CB GLN 498 -26.042 52.237 13.635 1.00
38.15 6 ATOM 808 CG GLN 498 -26.207 51.444 12.356 1.00 45.65 6 ATOM
809 CD GLN 498 -25.763 52.154 11.097 1.00 49.99 6 ATOM 810 OE1 GLN
498 -26.455 53.038 10.589 1.00 52.58 8 ATOM 811 NE2 GLN 498 -24.603
51.778 10.563 1.00 53.06 7 ATOM 812 C GLN 498 -24.662 53.648 15.172
1.00 31.48 6 ATOM 813 O GLN 498 -24.459 53.202 16.300 1.00 27.98 8
ATOM 814 N GLU 499 -24.990 54.911 14.920 1.00 30.75 7 ATOM 815 CA
GLU 499 -25.112 55.888 16.009 1.00 32.56 6 ATOM 816 CB GLU 499
-25.598 57.213 15.420 1.00 36.89 6 ATOM 817 CG GLU 499 -25.204
58.474 16.141 1.00 44.86 6 ATOM 818 CD GLU 499 -24.771 59.578
15.184 1.00 48.45 6 ATOM 819 OE1 GLU 499 -23.802 60.293 15.521 1.00
53.90 8 ATOM 820 OE2 GLU 499 -25.400 59.718 14.118 1.00 50.56 8
ATOM 821 C GLU 499 -26.130 55.315 16.980 1.00 31.14 6 ATOM 822 O
GLU 499 -27.136 54.818 16.475 1.00 31.94 8 ATOM 823 N GLY 500
-25.919 55.295 18.275 1.00 32.19 7 ATOM 824 CA GLY 500 -26.874
54.743 19.217 1.00 31.10 6 ATOM 825 C GLY 500 -26.643 53.325 19.696
1.00 31.51 6 ATOM 826 O GLY 500 -27.082 52.935 20.789 1.00 30.30 8
ATOM 827 N GLU 501 -25.948 52.497 18.921 1.00 34.41 7 ATOM 828 CA
GLU 501 -25.675 51.120 19.297 1.00 34.07 6 ATOM 829 CB GLU 501
-24.949 50.414 18.148 1.00 37.86 6 ATOM 830 CG GLU 501 -25.777
50.190 16.889 1.00 48.38 6 ATOM 831 CD GLU 501 -24.984 49.346
15.895 1.00 49.17 6 ATOM 832 OE1 GLU 501 -24.251 48.458 16.385 1.00
58.51 8 ATOM 833 OE2 GLU 501 -25.046 49.533 14.669 1.00 48.56 8
ATOM 834 C GLU 501 -24.783 51.018 20.537 1.00 33.06 6 ATOM 835 O
GLU 501 -24.086 51.978 20.886 1.00 27.70 8 ATOM 836 N THR 502
-24.747 49.809 21.107 1.00 31.92 7 ATOM 837 CA THR 502 -23.870
49.563 22.248 1.00 32.85 6 ATOM 838 CB THR 502 -24.508 48.705
23.341 1.00 35.75 6 ATOM 839 OG1 THR 502 -25.546 49.428 24.021 1.00
36.79 8 ATOM 840 CG2 THR 502 -23.532 48.289 24.441 1.00 35.82 6
ATOM 841 C THR 502 -22.582 48.922 21.721 1.00 32.54 6 ATOM 842 O
THR 502 -22.650 47.934 20.991 1.00 30.03 8 ATOM 843 N ILE 503
-21.431 49.537 22.014 1.00 28.53 7 ATOM 844 CA ILE 503 -20.162
48.927 21.590 1.00 25.40 6 ATOM 845 CB ILE 503 -19.131 49.993
21.163 1.00 26.58 6 ATOM 846 CG2 ILE 503 -17.776 49.370 20.828 1.00
25.47 6 ATOM 847 CG1 ILE 503 -19.669 50.786 19.971 1.00 21.79 6
ATOM 848 CD1 ILE 503 -18.739 51.863 19.438 1.00 19.73 6 ATOM 849 C
ILE 503 -19.624 48.113 22.767 1.00 25.27 6 ATOM 850 O ILE 503
-19.439 48.685 23.853 1.00 23.06 8 ATOM 851 N MET 504 -19.443
46.807 22.591 1.00 24.90 7 ATOM 852 CA MET 504 -18.893 45.953
23.639 1.00 21.55 6 ATOM 853 CB MET 504 -19.797 44.769 23.963 1.00
33.48 6 ATOM 854 CG MET 504 -20.810 45.040 25.101 1.00 29.68 6 ATOM
855 SD MET 504 -21.940 43.610 25.242 1.00 46.02 16 ATOM 856 CE MET
504 -22.667 43.650 23.589 1.00 31.10 6 ATOM 857 C MET 504 -17.528
45.410 23.215 1.00 21.27 6 ATOM 858 O MET 504 -17.374 44.875 22.106
1.00 22.96 8 ATOM 859 N LEU 505 -16.503 45.624 24.027 1.00 20.55 7
ATOM 860 CA LEU 505 -15.134 45.198 23.728 1.00 22.33 6 ATOM 861 CB
LEU 505 -14.192 46.416 23.550 1.00 14.66 6 ATOM 862 CG LEU 505
-14.713 47.477 22.561 1.00 18.89 6 ATOM 863 CD1 LEU 505 -13.796
48.688 22.489 1.00 19.44 6 ATOM 864 CD2 LEU 505 -14.882 46.810
21.186 1.00 18.70 6 ATOM 865 C LEU 505 -14.567 44.307 24.817 1.00
20.15 6 ATOM 866 O LEU 505 -15.050 44.360 25.950 1.00 18.39 8 ATOM
867 N ARG 506 -13.523 43.542 24.483 1.00 18.25 7 ATOM 868 CA ARG
506 -12.912 42.692 25.516 1.00 17.87 6 ATOM 869 CB ARG 506 -13.607
41.313 25.508 1.00 14.96 6 ATOM 870 CG ARG 506 -12.834 40.269
26.290 1.00 16.79 6 ATOM 871 CD ARG 506 -13.699 39.078 26.757 1.00
19.51 6 ATOM 872 NE ARG 506 -13.334 37.939 26.025 1.00 23.46 7 ATOM
873 CZ ARG 506 -12.990 36.692 26.065 1.00 24.43 6 ATOM 874 NH1 ARG
506 -12.923 35.974 27.176 1.00 25.93 7 ATOM 875 NH2 ARG 506 -12.697
36.071 24.936 1.00 18.72 7 ATOM 876 C ARG 506 -11.422 42.545 25.304
1.00 18.56 6 ATOM 877 O ARG 506 -10.998 42.387 24.142 1.00 20.43 8
ATOM 878 N CYS 507 -10.642 42.620 26.378 1.00 15.23 7 ATOM 879 CA
CYS 507 -9.189 42.447 26.292 1.00 14.89 6 ATOM 880 C CYS 507 -8.934
40.975 26.583 1.00 15.28 6 ATOM 881 O CYS 507 -9.296 40.572 27.690
1.00 15.96 8 ATOM 882 CB CYS 507 -8.438 43.301 27.322 1.00 14.55 6
ATOM 883 SG CYS 507 -6.691 43.498 27.013 1.00 13.91 16 ATOM 884 N
HIS 508 -8.446 40.213 25.604 1.00 15.07 7 ATOM 885 CA HIS 508
-8.334 38.763 25.811 1.00 11.91 6 ATOM 886 CB HIS 508 -9.190 38.109
24.708 1.00 16.03 6 ATOM 887 CG HIS 508 -9.119 36.626 24.572 1.00
16.94 6 ATOM 888 CD2 HIS 508 -9.068 35.843 23.462 1.00 17.64 6 ATOM
889 ND1 HIS 508 -9.103 35.758 25.657 1.00 17.41 7 ATOM 890 CE1 HIS
508 -9.034 34.516 25.215 1.00 17.37 6 ATOM 891 NE2 HIS 508 -9.021
34.533 23.895 1.00 20.00 7 ATOM 892 C HIS 508 -6.925 38.219 25.733
1.00 11.83 6 ATOM 893 O HIS 508 -6.224 38.505 24.762 1.00 12.54 8
ATOM 894 N SER 509 -6.515 37.364 26.654 1.00 13.70 7 ATOM 895 CA
SER 509 -5.160 36.775 26.605 1.00 11.70 6 ATOM 896 CB SER 509
-4.583 36.732 28.041 1.00 13.47 6 ATOM 897 OG SER 509 -5.609 36.021
28.800 1.00 16.16 8 ATOM 898 C SER 509 -5.190 35.407 25.970 1.00
14.21 6 ATOM 899 O SER 509 -6.180 34.634 25.903 1.00 14.63 8 ATOM
900 N TRP 510 -4.047 35.062
25.381 1.00 16.58 7 ATOM 901 CA TRP 510 -3.860 33.764 24.708 1.00
16.04 6 ATOM 902 CB TRP 510 -2.480 33.708 24.072 1.00 18.73 6 ATOM
903 CG TRP 510 -2.187 32.441 23.306 1.00 21.24 6 ATOM 904 CD2 TRP
510 -1.135 31.527 23.589 1.00 20.70 6 ATOM 905 CE2 TRP 510 -1.193
30.505 22.616 1.00 25.92 6 ATOM 906 CE3 TRP 510 -0.112 31.494
24.549 1.00 24.16 6 ATOM 907 CD1 TRP 510 -2.827 31.958 22.214 1.00
22.22 6 ATOM 908 NE1 TRP 510 -2.233 30.797 21.765 1.00 22.81 7 ATOM
909 CZ2 TRP 510 -0.276 29.462 22.568 1.00 24.18 6 ATOM 910 CZ3 TRP
510 0.781 30.432 24.509 1.00 30.15 6 ATOM 911 CH2 TRP 510 0.698
29.433 23.526 1.00 31.04 6 ATOM 912 C TRP 510 -4.082 32.621 25.681
1.00 14.44 6 ATOM 913 O TRP 510 -3.665 32.647 26.852 1.00 17.08 8
ATOM 914 N LYS 511 -4.928 31.667 25.294 1.00 19.42 7 ATOM 915 CA
LYS 511 -5.347 30.541 26.115 1.00 19.40 6 ATOM 916 CB LYS 511
-4.131 29.625 26.418 1.00 21.00 6 ATOM 917 CG LYS 511 -3.583 28.962
25.155 1.00 24.94 6 ATOM 918 CD LYS 511 -2.124 28.579 25.337 1.00
34.17 6 ATOM 919 CE LYS 511 -1.952 27.147 25.781 1.00 37.49 6 ATOM
920 NZ LYS 511 -2.783 26.198 24.987 1.00 52.66 7 ATOM 921 C LYS 511
-5.940 30.945 27.450 1.00 20.33 6 ATOM 922 O LYS 511 -5.905 30.172
28.419 1.00 16.80 8 ATOM 923 N ASP 512 -6.444 32.171 27.602 1.00
18.28 7 ATOM 924 CA ASP 512 -6.989 32.633 28.861 1.00 20.31 6 ATOM
925 CB ASP 512 -8.242 31.778 29.191 1.00 24.52 6 ATOM 926 CG ASP
512 -9.306 32.129 28.155 1.00 31.39 6 ATOM 927 OD1 ASP 512 -9.700
33.321 28.119 1.00 39.68 8 ATOM 928 OD2 ASP 512 -9.719 31.278
27.360 1.00 35.00 8 ATOM 929 C ASP 512 -6.015 32.663 30.018 1.00
23.40 6 ATOM 930 O ASP 512 -6.426 32.391 31.148 1.00 23.42 8 ATOM
931 N LYS 513 -4.731 32.977 29.785 1.00 23.10 7 ATOM 932 CA LYS 513
-3.792 33.145 30.891 1.00 22.35 6 ATOM 933 CB LYS 513 -2.352 33.434
30.437 1.00 21.68 6 ATOM 934 CG LYS 513 -1.758 32.255 29.659 1.00
27.09 6 ATOM 935 CD LYS 513 -0.232 32.292 29.608 1.00 28.34 6 ATOM
936 CE LYS 513 0.269 31.086 28.816 1.00 32.92 6 ATOM 937 NZ LYS 513
0.196 29.791 29.554 1.00 33.55 7 ATOM 938 C LYS 513 -4.352 34.269
31.748 1.00 19.86 6 ATOM 939 O LYS 513 -4.890 35.263 31.264 1.00
21.45 8 ATOM 940 N PRO 514 -4.288 34.105 33.066 1.00 20.08 7 ATOM
941 CD PRO 514 -3.701 32.938 33.768 1.00 16.95 6 ATOM 942 CA PRO
514 -4.923 35.065 33.957 1.00 17.00 6 ATOM 943 CB PRO 514 -4.548
34.574 35.342 1.00 19.22 6 ATOM 944 CG PRO 514 -4.169 33.133 35.176
1.00 21.34 6 ATOM 945 C PRO 514 -4.451 36.461 33.636 1.00 16.83 6
ATOM 946 O PRO 514 -3.237 36.741 33.512 1.00 16.01 8 ATOM 947 N LEU
515 -5.414 37.383 33.560 1.00 15.95 7 ATOM 948 CA LEU 515 -5.081
38.762 33.215 1.00 17.10 6 ATOM 949 CB LEU 515 -5.769 38.987 31.856
1.00 16.83 6 ATOM 950 CG LEU 515 -5.790 40.368 31.231 1.00 21.64 6
ATOM 951 CD1 LEU 515 -4.399 40.734 30.733 1.00 19.24 6 ATOM 952 CD2
LEU 515 -6.777 40.380 30.043 1.00 19.80 6 ATOM 953 C LEU 515 -5.606
39.750 34.226 1.00 21.13 6 ATOM 954 O LEU 515 -6.788 39.666 34.569
1.00 18.84 8 ATOM 955 N VAL 516 -4.839 40.761 34.630 1.00 20.51 7
ATOM 956 CA VAL 516 -5.314 41.793 35.545 1.00 20.40 6 ATOM 957 CB
VAL 516 -4.787 41.589 36.971 1.00 18.72 6 ATOM 958 CG1 VAL 516
-5.313 40.319 37.644 1.00 22.67 6 ATOM 959 CG2 VAL 516 -3.257
41.538 36.998 1.00 22.12 6 ATOM 960 C VAL 516 -4.807 43.163 35.073
1.00 19.73 6 ATOM 961 O VAL 516 -3.910 43.184 34.223 1.00 20.76 8
ATOM 962 N LYS 517 -5.268 44.251 35.693 1.00 17.34 7 ATOM 963 CA
LYS 517 -4.760 45.576 35.381 1.00 20.33 6 ATOM 964 CB LYS 517
-3.271 45.684 35.802 1.00 21.74 6 ATOM 965 CG LYS 517 -3.115 45.939
37.301 1.00 24.43 6 ATOM 966 CD LYS 517 -1.793 45.421 37.832 1.00
32.69 6 ATOM 967 CE LYS 517 -0.798 46.552 38.056 1.00 40.27 6 ATOM
968 NZ LYS 517 0.568 46.001 38.266 1.00 44.06 7 ATOM 969 C LYS 517
-4.956 45.930 33.914 1.00 18.58 6 ATOM 970 O LYS 517 -4.026 46.331
33.234 1.00 24.35 8 ATOM 971 N VAL 518 -6.181 45.803 33.417 1.00
20.45 7 ATOM 972 CA VAL 518 -6.542 46.068 32.039 1.00 19.15 6 ATOM
973 CB VAL 518 -7.756 45.223 31.607 1.00 12.17 6 ATOM 974 CG1 VAL
518 -8.199 45.470 30.176 1.00 18.94 6 ATOM 975 CG2 VAL 518 -7.408
43.737 31.794 1.00 16.75 6 ATOM 976 C VAL 518 -6.868 47.536 31.797
1.00 18.58 6 ATOM 977 O VAL 518 -7.606 48.149 32.564 1.00 17.16 8
ATOM 978 N THR 519 -6.307 48.063 30.711 1.00 15.94 7 ATOM 979 CA
THR 519 -6.527 49.441 30.335 1.00 16.50 6 ATOM 980 CB THR 519
-5.291 50.343 30.367 1.00 19.59 6 ATOM 981 OG1 THR 519 -4.770
50.456 31.693 1.00 23.11 8 ATOM 982 CG2 THR 519 -5.695 51.743
29.872 1.00 24.83 6 ATOM 983 C THR 519 -7.053 49.442 28.881 1.00
17.81 6 ATOM 984 O THR 519 -6.436 48.736 28.095 1.00 14.36 8 ATOM
985 N PHE 520 -8.121 50.187 28.643 1.00 14.86 7 ATOM 986 CA PHE 520
-8.616 50.258 27.259 1.00 13.85 6 ATOM 987 CB PHE 520 -10.122
50.069 27.240 1.00 15.51 6 ATOM 988 CG PHE 520 -10.553 48.636
27.463 1.00 13.38 6 ATOM 989 CD1 PHE 520 -10.748 48.165 28.750 1.00
20.15 6 ATOM 990 CD2 PHE 520 -10.792 47.815 26.381 1.00 20.08 6
ATOM 991 CE1 PHE 520 -11.186 46.864 28.953 1.00 17.14 6 ATOM 992
CE2 PHE 520 -11.230 46.499 26.578 1.00 22.12 6 ATOM 993 CZ PHE 520
-11.423 46.048 27.867 1.00 17.10 6 ATOM 994 C PHE 520 -8.279 51.650
26.721 1.00 17.13 6 ATOM 995 O PHE 520 -8.640 52.645 27.407 1.00
14.78 8 ATOM 996 N PHE 521 -7.626 51.700 25.575 1.00 16.20 7 ATOM
997 CA PHE 521 -7.277 52.998 25.011 1.00 18.83 6 ATOM 998 CB PHE
521 -5.799 53.045 24.616 1.00 13.50 6 ATOM 999 CG PHE 521 -4.768
52.814 25.656 1.00 18.60 6 ATOM 1000 CD1 PHE 521 -4.368 51.527
26.017 1.00 17.37 6 ATOM 1001 CD2 PHE 521 -4.208 53.905 26.334 1.00
18.44 6 ATOM 1002 CE1 PHE 521 -3.409 51.342 27.006 1.00 19.78 6
ATOM 1003 CE2 PHE 521 -3.260 53.693 27.313 1.00 22.69 6 ATOM 1004
CZ PHE 521 -2.843 52.421 27.660 1.00 15.74 6 ATOM 1005 C PHE 521
-8.074 53.327 23.749 1.00 18.44 6 ATOM 1006 O PHE 521 -8.351 52.412
22.987 1.00 15.63 8 ATOM 1007 N GLN 522 -8.333 54.613 23.480 1.00
19.35 7 ATOM 1008 CA GLN 522 -8.959 54.986 22.203 1.00 19.90 6 ATOM
1009 CB GLN 522 -10.396 55.487 22.317 1.00 16.32 6 ATOM 1010 CG GLN
522 -10.784 56.283 21.065 1.00 18.39 6 ATOM 1011 CD GLN 522 -12.050
57.102 21.247 1.00 21.98 6 ATOM 1012 OE1 GLN 522 -12.423 57.405
22.374 1.00 19.18 8 ATOM 1013 NE2 GLN 522 -12.700 57.470 20.153
1.00 24.51 7 ATOM 1014 C GLN 522 -8.067 56.092 21.609 1.00 15.34 6
ATOM 1015 O GLN 522 -7.789 57.034 22.321 1.00 17.30 8 ATOM 1016 N
ASN 523 -7.474 55.935 20.439 1.00 18.98 7 ATOM 1017 CA ASN 523
-6.542 56.891 19.859 1.00 22.95 6 ATOM 1018 CB ASN 523 -7.241
58.158 19.332 1.00 19.57 6 ATOM 1019 CG ASN 523 -8.228 57.736
18.244 1.00 26.31 6 ATOM 1020 OD1 ASN 523 -8.013 56.813 17.441 1.00
19.76 8 ATOM 1021 ND2 ASN 523 -9.375 58.403 18.213 1.00 28.57 7
ATOM 1022 C ASN 523 -5.397 57.223 20.803 1.00 21.02 6 ATOM 1023 O
ASN 523 -4.911 58.341 20.918 1.00 19.19 8 ATOM 1024 N GLY 524
-4.951 56.234 21.579 1.00 19.77 7 ATOM 1025 CA GLY 524 -3.852
56.350 22.495 1.00 16.41 6 ATOM 1026 C GLY 524 -4.159 56.981 23.844
1.00 14.85 6 ATOM 1027 O GLY 524 -3.210 57.208 24.611 1.00 15.05 8
ATOM 1028 N LYS 525 -5.405 57.256 24.133 1.00 13.81 7 ATOM 1029 CA
LYS 525 -5.830 57.869 25.379 1.00 21.18 6 ATOM 1030 CB LYS 525
-6.700 59.128 25.247 1.00 14.85 6 ATOM 1031 CG LYS 525 -6.934
59.834 26.559 1.00 16.28 6 ATOM 1032 CD LYS 525 -7.406 61.279
26.281 1.00 22.51 6 ATOM 1033 CE LYS 525 -7.925 61.877 27.587 1.00
30.62 6 ATOM 1034 NZ LYS 525 -8.822 63.048 27.330 1.00 36.72 7 ATOM
1035 C LYS 525 -6.725 56.852 26.121 1.00 18.20 6 ATOM 1036 O LYS
525 -7.648 56.341 25.509 1.00 19.98 8 ATOM 1037 N SER 526 -6.385
56.650 27.393 1.00 17.62 7 ATOM 1038 CA SER 526 -7.107 55.625
28.155 1.00 20.03 6 ATOM 1039 CB SER 526 -6.355 55.407 29.485 1.00
23.22 6 ATOM 1040 OG SER 526 -7.317 55.093 30.466 1.00 38.12 8 ATOM
1041 C SER 526 -8.541 56.043 28.389 1.00 17.85 6 ATOM 1042 O SER
526 -8.842 57.209 28.647 1.00 21.31 8 ATOM 1043 N GLN 527 -9.490
55.148 28.254 1.00 17.16 7 ATOM 1044 CA GLN 527 -10.898 55.351
28.408 1.00 17.45 6 ATOM 1045 CB GLN 527 -11.723 54.793 27.225 1.00
20.82 6 ATOM 1046 CG GLN 527 -11.352 55.447 25.897 1.00 18.56 6
ATOM 1047 CD GLN 527 -11.497 56.954 25.927 1.00 24.44 6 ATOM 1048
OE1 GLN 527 -12.606 57.450 26.116 1.00 31.62 8 ATOM 1049 NE2 GLN
527 -10.436 57.736 25.773 1.00 19.15 7 ATOM 1050 C GLN 527 -11.386
54.615 29.661 1.00 20.94 6 ATOM 1051 O GLN 527 -12.439 54.937
30.179 1.00 18.25 8 ATOM 1052 N LYS 528 -10.643 53.581 30.032 1.00
21.18 7 ATOM 1053 CA LYS 528 -11.070 52.818 31.216 1.00 23.10 6
ATOM 1054 CB LYS 528 -12.177 51.832 30.842 1.00 21.83 6 ATOM 1055
CG LYS 528 -12.683 50.984 32.013 1.00 24.67 6 ATOM 1056 CD LYS 528
-13.739 49.961 31.589 1.00 18.23 6 ATOM 1057 CE LYS 528 -14.048
49.120 32.870 1.00 27.02 6 ATOM 1058 NZ LYS 528 -15.081 48.072
32.574 1.00 24.24 7 ATOM 1059 C LYS 528 -9.884 52.022 31.754 1.00
24.93 6 ATOM 1060 O LYS 528 -9.193 51.385 30.960 1.00 20.79 8 ATOM
1061 N PHE 529 -9.678 52.044 33.062 1.00 21.39 7 ATOM 1062 CA PHE
529 -8.708 51.171 33.695 1.00 24.45 6 ATOM 1063 CB PHE 529 -7.610
51.940 34.458 1.00 25.50 6 ATOM 1064 CG PHE 529 -6.772 51.029
35.327 1.00 25.51 6 ATOM 1065 CD1 PHE 529 -5.799 50.236 34.762 1.00
19.40 6 ATOM 1066 CD2 PHE 529 -7.002 50.938 36.700 1.00 29.98 6
ATOM 1067 CE1 PHE 529 -5.026 49.375 35.535 1.00 25.00 6 ATOM 1068
CE2 PHE 529 -6.249 50.078 37.491 1.00 28.84 6 ATOM 1069 CZ PHE 529
-5.262 49.292 36.902 1.00 32.29 6 ATOM 1070 C PHE 529 -9.480 50.289
34.687 1.00 27.88 6 ATOM 1071 O PHE 529 -10.388 50.817 35.359 1.00
30.99 8 ATOM 1072 N SER 530 -9.134 49.020 34.853 1.00 26.67 7 ATOM
1073 CA SER 530 -9.779 48.225 35.917 1.00 24.98 6 ATOM 1074 CB SER
530 -11.025 47.522 35.422 1.00 21.29 6 ATOM 1075 OG SER 530 -11.271
46.401 36.250 1.00 25.72 8 ATOM 1076 C SER 530 -8.777 47.199 36.434
1.00 24.39 6 ATOM 1077 O SER 530 -8.123 46.581 35.576 1.00 24.91 8
ATOM 1078 N HIS 531 -8.668 46.977 37.730 1.00 22.12 7 ATOM 1079 CA
HIS 531 -7.710 45.965 38.204 1.00 23.65 6 ATOM 1080 CB HIS 531
-7.604 45.948 39.737 1.00 28.35 6 ATOM 1081 CG HIS 531 -6.859
47.160 40.197 1.00 23.57 6 ATOM 1082 CD2 HIS 531 -7.307 48.357
40.642 1.00 18.55 6 ATOM 1083 ND1 HIS 531 -5.478 47.200 40.170 1.00
26.69 7 ATOM 1084 CE1 HIS 531 -5.095 48.388 40.617 1.00 16.65 6
ATOM 1085 NE2 HIS 531 -6.173 49.102 40.890 1.00 23.94 7 ATOM 1086 C
HIS 531 -8.108 44.552 37.814 1.00 23.89 6 ATOM 1087 O HIS 531
-7.261 43.661 37.712 1.00 26.21 8 ATOM 1088 N LEU 532 -9.426 44.318
37.689 1.00 21.77 7 ATOM 1089 CA LEU 532 -9.886 42.966 37.480 1.00
20.70 6 ATOM 1090 CB LEU 532 -10.630 42.505 38.760 1.00 30.28 6
ATOM 1091 CG LEU 532 -10.022 42.782 40.148 1.00 26.56 6 ATOM 1092
CD1 LEU 532 -11.073 42.550 41.229 1.00 29.07 6 ATOM 1093 CD2 LEU
532 -8.814 41.886 40.435 1.00 24.99 6 ATOM 1094 C LEU 532 -10.762
42.722 36.279 1.00 22.94 6 ATOM 1095 O LEU 532 -10.794 41.540
35.900 1.00 22.01 8 ATOM 1096 N ASP 533 -11.541 43.685 35.778 1.00
21.75 7 ATOM 1097 CA ASP 533 -12.469 43.465 34.679 1.00 24.62 6
ATOM 1098 CB ASP 533 -13.560 44.539 34.854 1.00 29.71 6 ATOM 1099
CG ASP 533 -14.734 44.545 33.915 1.00 32.90 6 ATOM 1100 OD1 ASP 533
-14.837 43.612 33.083 1.00 32.91 8 ATOM 1101 OD2 ASP 533 -15.597
45.472 34.000 1.00 36.01 8 ATOM 1102 C ASP 533 -11.843 43.636
33.296 1.00 25.88 6 ATOM 1103 O ASP 533 -11.419 44.730 32.940 1.00
24.36 8 ATOM 1104 N PRO 534 -11.857 42.605 32.460 1.00 24.65 7 ATOM
1105 CD PRO 534 -12.347 41.246 32.778 1.00 22.97 6 ATOM 1106 CA PRO
534 -11.293 42.681 31.112 1.00 24.00 6 ATOM 1107 CB PRO 534 -10.889
41.204 30.870 1.00 24.02 6 ATOM 1108 CG PRO 534 -11.987 40.433
31.544 1.00 23.04 6 ATOM 1109 C PRO 534 -12.256 43.102 30.017 1.00
22.11 6 ATOM 1110 O PRO 534 -11.970 42.936 28.824 1.00 19.00 8 ATOM
1111 N THR 535 -13.420 43.654 30.350 1.00 21.43 7 ATOM 1112 CA THR
535 -14.424 44.061 29.401 1.00 24.98 6 ATOM 1113 CB THR 535 -15.748
43.282 29.593 1.00 27.24 6 ATOM 1114 OG1 THR 535 -16.331 43.801
30.796 1.00 24.99 8 ATOM 1115 CG2 THR 535 -15.461 41.797 29.706
1.00 26.07 6 ATOM 1116 C THR 535 -14.747 45.554 29.451 1.00 23.58 6
ATOM 1117 O THR 535 -14.445 46.237 30.423 1.00 26.14 8 ATOM 1118 N
PHE 536 -15.267 46.076 28.347 1.00 20.63 7 ATOM 1119 CA PHE 536
-15.549 47.475 28.150 1.00 20.10 6 ATOM 1120 CB PHE 536 -14.343
48.160 27.523 1.00 25.47 6 ATOM 1121 CG PHE 536 -14.408 49.616
27.170 1.00 25.61 6 ATOM 1122 CD1 PHE 536 -14.528 50.596 28.121
1.00 27.00 6 ATOM 1123 CD2 PHE 536 -14.332 50.019 25.841 1.00 27.45
6 ATOM 1124 CE1 PHE 536 -14.571 51.937 27.787 1.00 32.62 6 ATOM
1125 CE2 PHE 536 -14.385 51.350 25.490 1.00 28.46 6 ATOM 1126 CZ
PHE 536 -14.493 52.317 26.463 1.00 30.41 6 ATOM 1127 C PHE 536
-16.796 47.669 27.297 1.00 24.00 6 ATOM 1128 O PHE 536 -16.952
47.065 26.230 1.00 24.50 8 ATOM 1129 N SER 537 -17.665 48.572
27.730 1.00 21.97 7 ATOM 1130 CA SER 537 -18.914 48.856 27.050 1.00
26.52 6 ATOM 1131 CB SER 537 -20.120 48.448 27.908 1.00 30.03 6
ATOM 1132 OG SER 537 -20.769 47.307 27.412 1.00 44.19 8 ATOM 1133 C
SER 537 -19.128 50.359 26.840 1.00 27.38 6 ATOM 1134 O SER 537
-18.911 51.172 27.721 1.00 27.33 8 ATOM 1135 N ILE 538 -19.654
50.702 25.686 1.00 25.86 7 ATOM 1136 CA ILE 538 -20.004 52.060
25.343 1.00 29.46 6 ATOM 1137 CB ILE 538 -19.189 52.690 24.193 1.00
33.38 6 ATOM 1138 CG2 ILE 538 -19.669 54.118 23.941 1.00 27.23 6
ATOM 1139 CG1 ILE 538 -17.679 52.669 24.472 1.00 30.55 6 ATOM 1140
CD1 ILE 538 -16.817 52.711 23.223 1.00 29.53 6 ATOM 1141 C ILE 538
-21.477 51.991 24.926 1.00 29.88 6 ATOM 1142 O ILE 538 -21.768
51.489 23.849 1.00 27.99 8 ATOM 1143 N PRO 539 -22.345 52.390
25.837 1.00 31.71 7 ATOM 1144 CD PRO 539 -22.018 52.928 27.184 1.00
32.73 6 ATOM 1145 CA PRO 539 -23.776 52.468 25.598 1.00 33.85 6
ATOM 1146 CB PRO 539 -24.380 52.653 26.983 1.00 36.13 6 ATOM 1147
CG PRO 539 -23.248 52.482 27.950 1.00 34.99 6 ATOM 1148 C PRO 539
-24.030 53.706 24.741 1.00 35.63 6 ATOM 1149 O PRO 539 -23.324
54.706 24.888 1.00 38.22 8 ATOM 1150 N GLN 540 -24.974 53.658
23.827 1.00 36.97 7 ATOM 1151 CA GLN 540 -25.288 54.756 22.935 1.00
35.17 6 ATOM 1152 CB GLN 540 -26.223 55.742 23.631 1.00 43.87 6
ATOM 1153 CG GLN 540 -27.518 55.064 24.088 1.00 49.77 6 ATOM 1154
CD GLN 540 -27.883 55.584 25.468 1.00 56.21 6 ATOM 1155 OE1 GLN 540
-28.145 56.782 25.593 1.00 57.44 8 ATOM 1156 NE2 GLN 540 -27.883
54.705 26.468 1.00 57.25 7 ATOM 1157 C GLN 540 -24.060 55.448
22.362 1.00 34.61 6 ATOM 1158 O GLN 540 -23.677 56.582 22.693 1.00
33.34 8 ATOM 1159 N ALA 541 -23.473 54.755 21.391 1.00 29.80 7 ATOM
1160 CA ALA 541 -22.287 55.232 20.694 1.00 30.02 6 ATOM 1161 CB ALA
541 -21.778 54.121 19.774 1.00 27.89 6 ATOM 1162 C ALA 541 -22.561
56.466 19.832 1.00 29.52 6 ATOM 1163 O ALA 541 -23.650 56.596
19.263 1.00 29.60 8 ATOM 1164 N ASN 542 -21.528 57.284 19.665 1.00
30.60 7 ATOM 1165 CA ASN 542 -21.642 58.431 18.738 1.00 31.55 6
ATOM 1166 CB ASN 542 -21.985 59.727 19.453 1.00 30.39 6 ATOM 1167
CG ASN 542 -21.012 60.117 20.534 1.00 31.63 6 ATOM 1168 OD1 ASN 542
-19.838 60.443 20.268 1.00 27.57 8 ATOM 1169 ND2 ASN 542 -21.479
60.127 21.781 1.00 33.23 7 ATOM 1170 C ASN 542 -20.357 58.545
17.936 1.00 32.33 6 ATOM 1171 O ASN 542 -19.453 57.698 18.122 1.00
29.09 8 ATOM 1172 N HIS 543 -20.223 59.609 17.134 1.00 29.40 7 ATOM
1173 CA HIS 543 -19.075 59.780 16.266 1.00 28.82 6 ATOM 1174 CB HIS
543 -19.262 60.971 15.272 1.00 24.51 6 ATOM 1175 CG HIS 543 -20.360
60.632 14.295 1.00 31.72 6 ATOM 1176 CD2 HIS 543 -20.704 59.446
13.740 1.00 33.88 6 ATOM 1177 ND1 HIS 543 -21.278 61.538 13.822
1.00 32.86 7 ATOM 1178 CE1 HIS 543 -22.117 60.939 13.008 1.00 31.84
6 ATOM 1179 NE2 HIS 543 -21.794 59.664 12.941 1.00 31.48 7 ATOM
1180 C HIS 543 -17.747 60.009 16.976 1.00 26.62 6 ATOM 1181 O HIS
543 -16.696 59.768 16.366 1.00 25.96 8 ATOM 1182 N SER 544 -17.812
60.454 18.221 1.00 20.85 7 ATOM 1183 CA SER 544 -16.557 60.738
18.941 1.00 24.82 6 ATOM 1184 CB SER 544 -16.839 61.887 19.915 1.00
30.28 6 ATOM 1185 OG SER 544 -17.739 61.477 20.930 1.00 39.11 8
ATOM 1186 C SER 544 -15.976 59.443 19.474 1.00 24.89 6 ATOM 1187 O
SER 544 -14.775 59.348 19.755 1.00 25.22 8 ATOM 1188 N HIS 545
-16.746 58.344 19.463 1.00 20.33 7 ATOM 1189 CA HIS 545 -16.306
57.005 19.811 1.00 19.38 6 ATOM 1190 CB HIS 545 -17.474 56.104
20.302 1.00 19.40
6 ATOM 1191 CG HIS 545 -18.145 56.654 21.534 1.00 18.37 6 ATOM 1192
CD2 HIS 545 -17.620 56.980 22.744 1.00 18.22 6 ATOM 1193 ND1 HIS
545 -19.493 56.901 21.627 1.00 23.55 7 ATOM 1194 CE1 HIS 545
-19.768 57.374 22.829 1.00 26.33 6 ATOM 1195 NE2 HIS 545 -18.643
57.454 23.525 1.00 21.05 7 ATOM 1196 C HIS 545 -15.589 56.313
18.657 1.00 22.05 6 ATOM 1197 O HIS 545 -15.013 55.230 18.848 1.00
21.86 8 ATOM 1198 N SER 546 -15.569 56.869 17.440 1.00 20.66 7 ATOM
1199 CA SER 546 -14.833 56.217 16.363 1.00 19.96 6 ATOM 1200 CB SER
546 -15.075 56.857 14.986 1.00 20.48 6 ATOM 1201 OG SER 546 -16.442
56.712 14.613 1.00 25.61 8 ATOM 1202 C SER 546 -13.339 56.270
16.656 1.00 20.51 6 ATOM 1203 O SER 546 -12.915 57.252 17.287 1.00
22.06 8 ATOM 1204 N GLY 547 -12.556 55.288 16.197 1.00 16.70 7 ATOM
1205 CA GLY 547 -11.123 55.483 16.411 1.00 20.49 6 ATOM 1206 C GLY
547 -10.385 54.152 16.555 1.00 22.63 6 ATOM 1207 O GLY 547 -10.982
53.104 16.332 1.00 16.09 8 ATOM 1208 N ASP 548 -9.111 54.306 16.951
1.00 20.62 7 ATOM 1209 CA ASP 548 -8.324 53.089 17.121 1.00 21.57 6
ATOM 1210 CB ASP 548 -6.882 53.287 16.674 1.00 28.99 6 ATOM 1211 CG
ASP 548 -6.819 53.722 15.219 1.00 41.07 6 ATOM 1212 OD1 ASP 548
-7.849 53.528 14.540 1.00 39.21 8 ATOM 1213 OD2 ASP 548 -5.763
54.246 14.808 1.00 39.40 8 ATOM 1214 C ASP 548 -8.315 52.652 18.590
1.00 20.72 6 ATOM 1215 O ASP 548 -7.817 53.397 19.447 1.00 20.27 8
ATOM 1216 N TYR 549 -8.822 51.426 18.798 1.00 16.97 7 ATOM 1217 CA
TYR 549 -8.811 50.900 20.164 1.00 18.60 6 ATOM 1218 CB TYR 549
-10.193 50.279 20.472 1.00 16.94 6 ATOM 1219 CG TYR 549 -11.272
51.332 20.606 1.00 18.45 6 ATOM 1220 CD1 TYR 549 -11.901 51.938
19.528 1.00 19.27 6 ATOM 1221 CE1 TYR 549 -12.877 52.918 19.737
1.00 20.18 6 ATOM 1222 CD2 TYR 549 -11.672 51.704 21.879 1.00 18.36
6 ATOM 1223 CE2 TYR 549 -12.636 52.650 22.116 1.00 15.60 6 ATOM
1224 CZ TYR 549 -13.238 53.260 21.027 1.00 18.77 6 ATOM 1225 OH TYR
549 -14.211 54.206 21.253 1.00 18.41 8 ATOM 1226 C TYR 549 -7.767
49.805 20.355 1.00 15.78 6 ATOM 1227 O TYR 549 -7.539 49.007 19.450
1.00 15.86 8 ATOM 1228 N HIS 550 -7.196 49.740 21.559 1.00 15.01 7
ATOM 1229 CA HIS 550 -6.247 48.695 21.925 1.00 12.99 6 ATOM 1230 CB
HIS 550 -4.849 48.886 21.372 1.00 11.96 6 ATOM 1231 CG HIS 550
-3.942 49.834 22.117 1.00 17.71 6 ATOM 1232 CD2 HIS 550 -2.944
49.571 23.004 1.00 16.09 6 ATOM 1233 ND1 HIS 550 -3.988 51.206
21.971 1.00 11.60 7 ATOM 1234 CE1 HIS 550 -3.058 51.763 22.716 1.00
16.95 6 ATOM 1235 NE2 HIS 550 -2.407 50.809 23.370 1.00 19.22 7
ATOM 1236 C HIS 550 -6.263 48.596 23.462 1.00 13.37 6 ATOM 1237 O
HIS 550 -6.922 49.418 24.129 1.00 12.78 8 ATOM 1238 N CYS 551
-5.680 47.511 23.957 1.00 14.21 7 ATOM 1239 CA CYS 551 -5.670
47.307 25.414 1.00 15.38 6 ATOM 1240 C CYS 551 -4.301 46.884 25.880
1.00 16.27 6 ATOM 1241 O CYS 551 -3.422 46.462 25.132 1.00 15.15 8
ATOM 1242 CB CYS 551 -6.746 46.304 25.856 1.00 16.85 6 ATOM 1243 SG
CYS 551 -6.581 44.597 25.248 1.00 14.82 16 ATOM 1244 N THR 552
-4.080 47.061 27.186 1.00 17.41 7 ATOM 1245 CA THR 552 -2.875
46.643 27.862 1.00 17.27 6 ATOM 1246 CB THR 552 -1.899 47.735
28.305 1.00 21.80 6 ATOM 1247 OG1 THR 552 -2.527 48.654 29.205 1.00
17.53 8 ATOM 1248 CG2 THR 552 -1.356 48.478 27.075 1.00 17.12 6
ATOM 1249 C THR 552 -3.346 45.877 29.127 1.00 19.83 6 ATOM 1250 O
THR 552 -4.471 46.142 29.600 1.00 16.21 8 ATOM 1251 N GLY 553
-2.496 44.953 29.534 1.00 17.84 7 ATOM 1252 CA GLY 553 -2.815
44.160 30.731 1.00 20.33 6 ATOM 1253 C GLY 553 -1.647 43.261 31.108
1.00 18.60 6 ATOM 1254 O GLY 553 -0.779 42.951 30.293 1.00 19.87 8
ATOM 1255 N ASN 554 -1.603 42.866 32.373 1.00 20.99 7 ATOM 1256 CA
ASN 554 -0.560 42.051 32.959 1.00 20.36 6 ATOM 1257 CB ASN 554
-0.512 42.310 34.478 1.00 26.77 6 ATOM 1258 CG ASN 554 0.800 42.938
34.897 1.00 40.91 6 ATOM 1259 OD1 ASN 554 1.700 42.286 35.441 1.00
46.67 8 ATOM 1260 ND2 ASN 554 0.927 44.227 34.633 1.00 40.24 7 ATOM
1261 C ASN 554 -0.879 40.566 32.817 1.00 22.51 6 ATOM 1262 O ASN
554 -1.973 40.181 33.272 1.00 22.15 8 ATOM 1263 N ILE 555 0.018
39.799 32.202 1.00 19.40 7 ATOM 1264 CA ILE 555 -0.198 38.352
32.139 1.00 22.27 6 ATOM 1265 CB ILE 555 -0.210 37.750 30.731 1.00
26.29 6 ATOM 1266 CG2 ILE 555 -0.327 36.226 30.831 1.00 23.31 6
ATOM 1267 CG1 ILE 555 -1.367 38.322 29.899 1.00 28.16 6 ATOM 1268
CD1 ILE 555 -1.371 37.992 28.434 1.00 29.42 6 ATOM 1269 C ILE 555
0.974 37.777 32.941 1.00 27.67 6 ATOM 1270 O ILE 555 2.112 38.140
32.639 1.00 24.10 8 ATOM 1271 N GLY 556 0.732 37.028 34.020 1.00
33.10 7 ATOM 1272 CA GLY 556 1.942 36.581 34.780 1.00 37.62 6 ATOM
1273 C GLY 556 2.447 37.813 35.527 1.00 38.80 6 ATOM 1274 O GLY 556
1.659 38.354 36.299 1.00 43.91 8 ATOM 1275 N TYR 557 3.655 38.293
35.307 1.00 41.47 7 ATOM 1276 CA TYR 557 4.182 39.509 35.894 1.00
43.65 6 ATOM 1277 CB TYR 557 5.381 39.224 36.832 1.00 51.51 6 ATOM
1278 CG TYR 557 5.020 38.274 37.961 1.00 57.42 6 ATOM 1279 CD1 TYR
557 5.523 36.981 37.982 1.00 60.45 6 ATOM 1280 CE1 TYR 557 5.179
36.101 38.992 1.00 62.57 6 ATOM 1281 CD2 TYR 557 4.140 38.662
38.963 1.00 61.00 6 ATOM 1282 CE2 TYR 557 3.788 37.787 39.982 1.00
63.03 6 ATOM 1283 CZ TYR 557 4.313 36.513 39.986 1.00 63.56 6 ATOM
1284 OH TYR 557 3.979 35.629 40.984 1.00 66.68 8 ATOM 1285 C TYR
557 4.676 40.515 34.849 1.00 41.96 6 ATOM 1286 O TYR 557 5.445
41.446 35.115 1.00 41.33 8 ATOM 1287 N THR 558 4.298 40.319 33.594
1.00 36.77 7 ATOM 1288 CA THR 558 4.722 41.173 32.496 1.00 30.71 6
ATOM 1289 CB THR 558 5.260 40.269 31.364 1.00 30.82 6 ATOM 1290 OG1
THR 558 6.237 39.395 31.942 1.00 30.47 8 ATOM 1291 CG2 THR 558
5.851 41.047 30.207 1.00 29.21 6 ATOM 1292 C THR 558 3.532 41.922
31.912 1.00 25.66 6 ATOM 1293 O THR 558 2.521 41.257 31.642 1.00
24.50 8 ATOM 1294 N LEU 559 3.689 43.202 31.609 1.00 21.00 7 ATOM
1295 CA LEU 559 2.617 43.942 30.960 1.00 21.01 6 ATOM 1296 CB LEU
559 2.737 45.431 31.284 1.00 26.53 6 ATOM 1297 CG LEU 559 1.601
46.379 30.958 1.00 27.15 6 ATOM 1298 CD1 LEU 559 0.323 46.049
31.713 1.00 25.15 6 ATOM 1299 CD2 LEU 559 1.979 47.830 31.316 1.00
28.75 6 ATOM 1300 C LEU 559 2.654 43.687 29.461 1.00 22.04 6 ATOM
1301 O LEU 559 3.711 43.618 28.844 1.00 22.64 8 ATOM 1302 N PHE 560
1.484 43.470 28.855 1.00 20.79 7 ATOM 1303 CA PHE 560 1.430 43.290
27.409 1.00 19.10 6 ATOM 1304 CB PHE 560 0.821 41.920 27.060 1.00
20.91 6 ATOM 1305 CG PHE 560 1.848 40.832 27.216 1.00 19.50 6 ATOM
1306 CD1 PHE 560 1.971 40.190 28.442 1.00 24.86 6 ATOM 1307 CD2 PHE
560 2.645 40.457 26.156 1.00 21.03 6 ATOM 1308 CE1 PHE 560 2.903
39.157 28.588 1.00 29.44 6 ATOM 1309 CE2 PHE 560 3.582 39.445
26.296 1.00 19.89 6 ATOM 1310 CZ PHE 560 3.704 38.792 27.529 1.00
25.34 6 ATOM 1311 C PHE 560 0.521 44.353 26.794 1.00 17.36 6 ATOM
1312 O PHE 560 -0.346 44.884 27.504 1.00 18.36 8 ATOM 1313 N SER
561 0.753 44.626 25.521 1.00 17.60 7 ATOM 1314 CA SER 561 -0.087
45.564 24.785 1.00 14.63 6 ATOM 1315 CB SER 561 0.744 46.716 24.188
1.00 20.14 6 ATOM 1316 OG SER 561 -0.115 47.812 23.901 1.00 21.55 8
ATOM 1317 C SER 561 -0.662 44.829 23.561 1.00 18.96 6 ATOM 1318 O
SER 561 0.101 44.113 22.894 1.00 19.79 8 ATOM 1319 N SER 562 -1.921
45.070 23.232 1.00 16.19 7 ATOM 1320 CA SER 562 -2.518 44.462
22.049 1.00 16.74 6 ATOM 1321 CB SER 562 -4.029 44.188 22.233 1.00
16.78 6 ATOM 1322 OG SER 562 -4.801 45.336 21.900 1.00 21.00 8 ATOM
1323 C SER 562 -2.322 45.381 20.845 1.00 18.24 6 ATOM 1324 O SER
562 -1.949 46.561 20.987 1.00 16.85 8 ATOM 1325 N LYS 563 -2.535
44.839 19.652 1.00 17.96 7 ATOM 1326 CA LYS 563 -2.484 45.663
18.445 1.00 17.36 6 ATOM 1327 CB LYS 563 -2.369 44.909 17.133 1.00
20.94 6 ATOM 1328 CG LYS 563 -1.228 43.981 16.902 1.00 25.34 6 ATOM
1329 CD LYS 563 0.128 44.595 16.685 1.00 29.02 6 ATOM 1330 CE LYS
563 0.954 43.735 15.721 1.00 42.35 6 ATOM 1331 NZ LYS 563 0.495
42.308 15.692 1.00 38.14 7 ATOM 1332 C LYS 563 -3.821 46.400 18.391
1.00 17.27 6 ATOM 1333 O LYS 563 -4.817 45.960 18.978 1.00 16.54 8
ATOM 1334 N PRO 564 -3.840 47.518 17.696 1.00 18.39 7 ATOM 1335 CD
PRO 564 -2.702 48.123 16.952 1.00 20.79 6 ATOM 1336 CA PRO 564
-5.060 48.294 17.546 1.00 19.84 6 ATOM 1337 CB PRO 564 -4.545
49.689 17.142 1.00 17.33 6 ATOM 1338 CG PRO 564 -3.254 49.450
16.475 1.00 21.76 6 ATOM 1339 C PRO 564 -6.032 47.697 16.528 1.00
19.62 6 ATOM 1340 O PRO 564 -5.723 46.924 15.619 1.00 19.46 8 ATOM
1341 N VAL 565 -7.295 48.033 16.674 1.00 17.22 7 ATOM 1342 CA VAL
565 -8.427 47.704 15.841 1.00 20.36 6 ATOM 1343 CB VAL 565 -9.405
46.676 16.450 1.00 20.84 6 ATOM 1344 CG1 VAL 565 -10.418 46.223
15.404 1.00 20.46 6 ATOM 1345 CG2 VAL 565 -8.699 45.391 16.899 1.00
23.72 6 ATOM 1346 C VAL 565 -9.173 49.033 15.590 1.00 22.05 6 ATOM
1347 O VAL 565 -9.532 49.772 16.499 1.00 22.10 8 ATOM 1348 N THR
566 -9.444 49.317 14.320 1.00 24.93 7 ATOM 1349 CA THR 566 -10.111
50.549 13.939 1.00 26.07 6 ATOM 1350 CB THR 566 -9.631 51.082
12.579 1.00 31.66 6 ATOM 1351 OG1 THR 566 -9.737 50.055 11.569 1.00
38.39 8 ATOM 1352 CG2 THR 566 -8.180 51.513 12.694 1.00 23.71 6
ATOM 1353 C THR 566 -11.611 50.269 13.909 1.00 25.06 6 ATOM 1354 O
THR 566 -11.985 49.330 13.244 1.00 21.88 8 ATOM 1355 N ILE 567
-12.362 50.988 14.714 1.00 21.40 7 ATOM 1356 CA ILE 567 -13.784
50.959 14.909 1.00 25.06 6 ATOM 1357 CB ILE 567 -14.088 50.702
16.424 1.00 26.21 6 ATOM 1358 CG2 ILE 567 -15.588 50.707 16.673
1.00 26.68 6 ATOM 1359 CG1 ILE 567 -13.415 49.394 16.825 1.00 26.56
6 ATOM 1360 CD1 ILE 567 -13.946 48.548 17.939 1.00 30.83 6 ATOM
1361 C ILE 567 -14.416 52.294 14.501 1.00 24.36 6 ATOM 1362 O ILE
567 -14.013 53.384 14.920 1.00 23.36 8 ATOM 1363 N THR 568 -15.412
52.275 13.630 1.00 22.83 7 ATOM 1364 CA THR 568 -16.083 53.461
13.152 1.00 27.27 6 ATOM 1365 CB THR 568 -15.945 53.600 11.622 1.00
31.88 6 ATOM 1366 OG1 THR 568 -14.565 53.495 11.277 1.00 32.11 8
ATOM 1367 CG2 THR 568 -16.462 54.972 11.179 1.00 34.54 6 ATOM 1368
C THR 568 -17.575 53.452 13.501 1.00 28.53 6 ATOM 1369 O THR 568
-18.190 52.383 13.508 1.00 32.64 8 ATOM 1370 N VAL 569 -18.090
54.606 13.863 1.00 23.55 7 ATOM 1371 CA VAL 569 -19.472 54.855
14.163 1.00 27.27 6 ATOM 1372 CB VAL 569 -19.728 55.507 15.523 1.00
28.51 6 ATOM 1373 CG1 VAL 569 -21.227 55.733 15.757 1.00 26.42 6
ATOM 1374 CG2 VAL 569 -19.189 54.706 16.696 1.00 27.97 6 ATOM 1375
C VAL 569 -20.011 55.844 13.098 1.00 32.65 6 ATOM 1376 O VAL 569
-19.332 56.810 12.710 1.00 33.21 8 ATOM 1377 N GLN 570 -21.245
55.670 12.689 0.01 33.85 7 ATOM 1378 CA GLN 570 -21.966 56.476
11.737 0.01 35.75 6 ATOM 1379 CB GLN 570 -23.335 56.839 12.362 0.01
36.48 6 ATOM 1380 CG GLN 570 -24.465 56.854 11.347 0.01 37.54 6
ATOM 1381 CD GLN 570 -25.478 55.756 11.599 0.01 37.91 6 ATOM 1382
OE1 GLN 570 -25.142 54.680 12.096 0.01 38.17 8 ATOM 1383 NE2 GLN
570 -26.735 56.020 11.257 0.01 38.21 7 ATOM 1384 C GLN 570 -21.355
57.778 11.241 0.01 36.70 6 ATOM 1385 O GLN 570 -21.049 58.699
11.995 0.01 36.81 8 ATOM 1386 N VAL 571 -21.273 57.907 9.919 0.01
37.51 7 ATOM 1387 CA VAL 571 -20.781 59.094 9.240 0.01 38.20 6 ATOM
1388 CB VAL 571 -19.483 59.658 9.842 0.01 38.61 6 ATOM 1389 CG1 VAL
571 -18.334 58.667 9.681 0.01 38.88 6 ATOM 1390 CG2 VAL 571 -19.115
60.985 9.180 0.01 38.83 6 ATOM 1391 C VAL 571 -20.587 58.818 7.750
0.01 38.42 6 ATOM 1392 O VAL 571 -21.420 59.293 6.949 0.01 38.53 8
ATOM 1 OW0 WAT 601 -13.958 32.760 19.930 1.00 18.36 8 ATOM 2 OW0
WAT 602 -13.653 59.625 23.320 1.00 24.59 8 ATOM 3 OW0 WAT 603
-5.895 43.456 18.965 1.00 14.14 8 ATOM 4 OW0 WAT 604 -9.519 28.178
30.514 1.00 42.11 8 ATOM 5 OW0 WAT 605 -8.700 36.412 28.355 1.00
21.65 8 ATOM 6 OW0 WAT 606 -25.548 35.202 7.898 1.00 24.88 8 ATOM 7
OW0 WAT 607 -2.902 48.395 31.897 1.00 19.13 8 ATOM 8 OW0 WAT 608
-14.303 55.610 23.676 1.00 24.28 8 ATOM 9 OW0 WAT 609 -10.371
38.314 29.076 1.00 27.73 8 ATOM 10 OW0 WAT 610 -12.433 34.237
21.505 1.00 14.04 8 ATOM 11 OW0 WAT 611 -5.417 53.367 21.002 1.00
16.89 8 ATOM 12 OW0 WAT 612 -29.599 18.069 11.595 1.00 34.62 8 ATOM
13 OW0 WAT 613 -17.813 30.679 2.648 1.00 16.34 8 ATOM 14 OW0 WAT
614 -6.656 42.551 16.413 1.00 24.31 8 ATOM 15 OW0 WAT 615 -21.191
20.720 5.335 1.00 30.05 8 ATOM 16 OW0 WAT 616 -15.621 34.100 18.319
1.00 18.82 8 ATOM 17 OW0 WAT 617 -6.528 44.456 14.460 1.00 26.68 8
ATOM 18 OW0 WAT 618 -6.213 31.143 22.792 1.00 19.89 8 ATOM 19 OW0
WAT 619 -12.935 32.992 24.109 1.00 29.95 8 ATOM 20 OW0 WAT 620
2.277 38.630 20.953 1.00 28.34 8 ATOM 21 OW0 WAT 621 -20.151 29.522
0.183 1.00 21.62 8 ATOM 22 OW0 WAT 622 -27.773 35.663 6.295 1.00
20.74 8 ATOM 23 OW0 WAT 623 0.481 42.002 19.811 1.00 24.67 8 ATOM
24 OW0 WAT 624 -17.815 32.952 1.120 1.00 26.99 8 ATOM 25 OW0 WAT
625 -16.604 36.105 25.523 1.00 18.45 8 ATOM 26 OW0 WAT 626 0.330
41.286 22.516 1.00 29.01 8 ATOM 27 OW0 WAT 627 -13.324 59.911
17.129 1.00 40.98 8 ATOM 28 OW0 WAT 628 -9.214 59.486 22.450 1.00
41.91 8 ATOM 29 OW0 WAT 629 -20.146 18.596 13.850 1.00 50.03 8 ATOM
30 OW0 WAT 630 -21.707 20.513 12.325 1.00 18.46 8 ATOM 31 OW0 WAT
631 -15.403 33.699 25.599 1.00 21.44 8 ATOM 32 OW0 WAT 632 -12.703
37.608 30.174 1.00 37.28 8 ATOM 33 OW0 WAT 633 -12.479 39.466
39.250 1.00 23.78 8 ATOM 34 OW0 WAT 634 -13.921 41.406 9.106 1.00
40.49 8 ATOM 35 OW0 WAT 635 -7.230 28.485 24.432 1.00 41.81 8 ATOM
36 OW0 WAT 636 -2.989 42.185 19.344 1.00 17.29 8 ATOM 37 OW0 WAT
637 -12.865 25.830 10.180 1.00 47.19 8 ATOM 38 OW0 WAT 638 -2.754
32.875 13.259 1.00 35.75 8 ATOM 39 OW0 WAT 639 -17.416 43.258
26.641 1.00 32.09 8 ATOM 40 OW0 WAT 640 -31.068 25.287 10.888 1.00
20.85 8 ATOM 41 OW0 WAT 641 -17.725 28.881 21.261 1.00 25.43 8 ATOM
42 OW0 WAT 642 -32.760 35.615 6.079 1.00 38.04 8 ATOM 43 OW0 WAT
643 -14.079 28.493 25.218 1.00 20.23 8 ATOM 44 OW0 WAT 644 -16.644
22.930 -2.315 1.00 34.00 8 ATOM 45 OW0 WAT 645 -1.790 38.223 35.518
1.00 30.63 8 ATOM 46 OW0 WAT 646 -10.026 24.026 13.639 1.00 31.10 8
ATOM 47 OW0 WAT 647 -11.096 60.328 24.599 1.00 33.25 8 ATOM 48 OW0
WAT 648 -19.457 27.850 -2.970 1.00 36.88 8 ATOM 49 OW0 WAT 649
-18.578 40.758 26.756 1.00 30.86 8 ATOM 50 OW0 WAT 650 -11.119
22.191 16.190 1.00 37.83 8 ATOM 51 OW0 WAT 651 -2.583 24.179 28.032
1.00 73.18 8 ATOM 52 OW0 WAT 652 -0.243 25.713 22.803 1.00 34.15 8
ATOM 53 OW0 WAT 653 -33.328 18.701 10.255 1.00 23.17 8 ATOM 54 OW0
WAT 654 -22.212 13.785 5.080 1.00 51.41 8 ATOM 55 OW0 WAT 655
-21.393 16.945 11.680 1.00 31.47 8 ATOM 56 OW0 WAT 656 -37.174
28.484 4.349 1.00 36.66 8 ATOM 57 OW0 WAT 657 -23.291 46.916 13.981
1.00 45.02 8 ATOM 58 OW0 WAT 658 -31.521 20.732 5.404 1.00 28.19 8
ATOM 59 OW0 WAT 659 -11.904 22.697 8.209 1.00 61.39 8 ATOM 60 OW0
WAT 660 -7.393 64.706 24.668 1.00 45.96 8 ATOM 61 OW0 WAT 661
-12.356 29.912 23.727 1.00 23.77 8 ATOM 62 OW0 WAT 662 -33.898
31.788 7.353 1.00 32.96 8 ATOM 63 OW0 WAT 663 -28.502 48.102 25.478
1.00 58.40 8 ATOM 64 OW0 WAT 664 -23.414 63.056 18.427 1.00 35.16 8
ATOM 65 OW0 WAT 665 -4.792 26.235 16.778 1.00 44.49 8 ATOM 66 OW0
WAT 666 -28.509 23.145 -1.620 1.00 50.51 8 ATOM 67 OW0 WAT 667
-19.685 32.378 -0.712 1.00 45.74 8 ATOM 68 OW0 WAT 668 -10.899
26.379 23.620 1.00 43.61 8 ATOM 69 OW0 WAT 669 1.033 27.146 20.128
1.00 34.52 8 ATOM 70 OW0 WAT 670 -15.215 33.469 0.077 1.00 27.35 8
ATOM 71 OW0 WAT 671 -8.748 20.877 16.508 1.00 51.59 8 ATOM 72 OW0
WAT 672 -22.332 18.552 3.707 1.00 30.25 8 ATOM 73 OW0 WAT 673
-23.373 30.095 17.610 1.00 22.44 8 ATOM 74 OW0 WAT 674 -11.965
32.994 26.359 1.00 26.92 8 ATOM 75 OW0 WAT 675 -35.793 29.720 7.198
1.00 27.19 8 ATOM 76 OW0 WAT 676 -10.333 28.336 25.867 1.00 46.78 8
ATOM 77 OW0 WAT 677 -17.230 31.681 24.852 1.00 26.22 8 ATOM 78 OW0
WAT 678 -17.594 49.434 30.830 1.00 32.58 8 ATOM 79 OW0 WAT 679
-8.561 33.163 32.884 1.00 37.04 8 ATOM 80 OW0 WAT 680 -16.374
29.101 -4.195 1.00 31.45 8 ATOM 81 OW0 WAT 681 -8.995 30.537 24.946
1.00 36.64 8 ATOM 82 OW0 WAT 682 -19.019 53.815 28.676 1.00 48.06 8
ATOM 83 OW0 WAT 683 -20.039 39.516 15.742 1.00 23.23 8 ATOM 84 OW0
WAT 684 -21.308 45.557 20.658 1.00 28.24 8 ATOM 85 OW0 WAT 685
-7.405 30.847 5.261 1.00 41.47 8 ATOM 86 OW0 WAT 686 -23.729 34.800
0.632 1.00 30.27 8 ATOM 87 OW0 WAT 687 -15.826 60.771 23.946 1.00
41.94 8 ATOM 88 OW0 WAT 688 0.119 50.495 24.812 0.50 25.93 8 ATOM
89 OW0 WAT 689 -3.397 45.987 42.245 1.00 29.87 8 ATOM 90 OW0 WAT
690 -10.215 47.715 32.270 1.00 43.33 8 ATOM
91 OW0 WAT 691 -8.440 35.757 33.883 1.00 34.09 8 END
[0144]
3TABLE 3 REMARK Homology model of Fc epsilon Receptor I by V. C.
Epa; based on structure of FcgRIIa by K. Maxwell. REMARK Produced
by MODELLER: 24-Aug-98 01:02:51 REMARK MODELLER OBJECTIVE FUNCTION:
643.1817 1 ATOM 1 N VAL 1 36.442 43.253 22.184 1.00 0.14 1SG 2 ATOM
2 CA VAL 1 37.922 43.321 22.176 1.00 0.14 1SG 3 ATOM 3 CB VAL 1
38.483 42.986 23.538 1.00 0.14 1SG 4 ATOM 4 CG1 VAL 1 38.026 44.080
24.516 1.00 0.14 1SG 5 ATOM 5 CG2 VAL 1 38.051 41.576 23.970 1.00
0.14 1SG 6 ATOM 6 C VAL 1 38.614 42.508 21.119 1.00 0.14 1SG 7 ATOM
7 O VAL 1 39.758 42.821 20.796 1.00 0.14 1SG 8 ATOM 8 N PRO 2
38.026 41.492 20.533 1.00 0.15 1SG 9 ATOM 9 CA PRO 2 38.761 40.840
19.488 1.00 0.15 1SG 10 ATOM 10 CD PRO 2 37.208 40.531 21.266 1.00
0.15 1SG 11 ATOM 11 CB PRO 2 38.099 39.483 19.270 1.00 0.15 1SG 12
ATOM 12 CG PRO 2 37.502 39.155 20.647 1.00 0.15 1SG 13 ATOM 13 C
PRO 2 38.754 41.707 18.276 1.00 0.15 1SG 14 ATOM 14 O PRO 2 37.885
42.569 18.163 1.00 0.15 1SG 15 ATOM 15 N GLN 3 39.714 41.495 17.359
1.00 0.19 1SG 16 ATOM 16 CA GLN 3 39.782 42.301 16.180 1.00 0.19
1SG 17 ATOM 17 CB GLN 3 40.951 41.913 15.260 1.00 0.19 1SG 18 ATOM
18 CG GLN 3 41.177 42.871 14.092 1.00 0.19 1SG 19 ATOM 19 CD GLN 3
42.430 42.400 13.369 1.00 0.19 1SG 20 ATOM 20 OE1 GLN 3 42.839
41.249 13.508 1.00 0.19 1SG 21 ATOM 21 NE2 GLN 3 43.063 43.312
12.584 1.00 0.19 1SG 22 ATOM 22 C GLN 3 38.497 42.103 15.448 1.00
0.19 1SG 23 ATOM 23 O GLN 3 37.821 41.091 15.627 1.00 0.19 1SG 24
ATOM 24 N LYS 4 38.112 43.088 14.614 1.00 0.23 1SG 25 ATOM 25 CA
LYS 4 36.855 42.998 13.932 1.00 0.23 1SG 26 ATOM 26 CB LYS 4 36.146
44.354 13.776 1.00 0.23 1SG 27 ATOM 27 CG LYS 4 35.714 44.972
15.107 1.00 0.23 1SG 28 ATOM 28 CD LYS 4 35.315 46.446 14.996 1.00
0.23 1SG 29 ATOM 29 CE LYS 4 36.506 47.386 14.804 1.00 0.23 1SG 30
ATOM 30 NZ LYS 4 36.033 48.778 14.631 1.00 0.23 1SG 31 ATOM 31 C
LYS 4 37.089 42.464 12.560 1.00 0.23 1SG 32 ATOM 32 O LYS 4 37.990
42.883 11.834 1.00 0.23 1SG 33 ATOM 33 N PRO 5 36.261 41.520 12.218
1.00 0.25 1SG 34 ATOM 34 CA PRO 5 36.316 40.878 10.938 1.00 0.25
1SG 35 ATOM 35 CD PRO 5 34.937 41.436 12.804 1.00 0.25 1SG 36 ATOM
36 CB PRO 5 35.140 39.910 10.930 1.00 0.25 1SG 37 ATOM 37 CG PRO 5
34.094 40.656 11.780 1.00 0.25 1SG 38 ATOM 38 C PRO 5 36.086 41.953
9.932 1.00 0.25 1SG 39 ATOM 39 O PRO 5 35.464 42.958 10.275 1.00
0.25 1SG 40 ATOM 40 N LYS 6 36.592 41.786 8.699 1.00 0.35 1SG 41
ATOM 41 CA LYS 6 36.336 42.790 7.714 1.00 0.35 1SG 42 ATOM 42 CB
LYS 6 37.597 43.344 7.030 1.00 0.35 1SG 43 ATOM 43 CG LYS 6 38.418
44.275 7.924 1.00 0.35 1SG 44 ATOM 44 CD LYS 6 39.065 43.574 9.120
1.00 0.35 1SG 45 ATOM 45 CE LYS 6 39.884 44.516 10.004 1.00 0.35
1SG 46 ATOM 46 NZ LYS 6 40.469 43.767 11.137 1.00 0.35 1SG 47 ATOM
47 C LYS 6 35.491 42.168 6.659 1.00 0.35 1SG 48 ATOM 48 O LYS 6
35.686 41.011 6.289 1.00 0.35 1SG 49 ATOM 49 N VAL 7 34.498 42.928
6.165 1.00 0.35 1SG 50 ATOM 50 CA VAL 7 33.668 42.408 5.124 1.00
0.35 1SG 51 ATOM 51 CB VAL 7 32.207 42.721 5.299 1.00 0.35 1SG 52
ATOM 52 CG1 VAL 7 32.014 44.247 5.280 1.00 0.35 1SG 53 ATOM 53 CG2
VAL 7 31.423 41.985 4.200 1.00 0.35 1SG 54 ATOM 54 C VAL 7 34.132
43.039 3.857 1.00 0.35 1SG 55 ATOM 55 O VAL 7 34.313 44.254 3.783
1.00 0.35 1SG 56 ATOM 56 N SER 8 34.363 42.211 2.825 1.00 0.17 1SG
57 ATOM 57 CA SER 8 34.831 42.734 1.580 1.00 0.17 1SG 58 ATOM 58 CB
SER 8 36.059 41.994 1.024 1.00 0.17 1SG 59 ATOM 59 OG SER 8 36.458
42.571 -0.210 1.00 0.17 1SG 60 ATOM 60 C SER 8 33.733 42.575 0.586
1.00 0.17 1SG 61 ATOM 61 O SER 8 33.030 41.566 0.575 1.00 0.17 1SG
62 ATOM 62 N LEU 9 33.552 43.593 -0.272 1.00 0.11 1SG 63 ATOM 63 CA
LEU 9 32.519 43.525 -1.257 1.00 0.11 1SG 64 ATOM 64 CB LEU 9 31.563
44.731 -1.198 1.00 0.11 1SG 65 ATOM 65 CG LEU 9 30.442 44.709
-2.253 1.00 0.11 1SG 66 ATOM 66 CD2 LEU 9 29.725 46.068 -2.316 1.00
0.11 1SG 67 ATOM 67 CD1 LEU 9 29.474 43.536 -2.025 1.00 0.11 1SG 68
ATOM 68 C LEU 9 33.175 43.554 -2.597 1.00 0.11 1SG 69 ATOM 69 O LEU
9 33.992 44.428 -2.883 1.00 0.11 1SG 70 ATOM 70 N ASN 10 32.851
42.565 -3.450 1.00 0.17 1SG 71 ATOM 71 CA ASN 10 33.401 42.565
-4.771 1.00 0.17 1SG 72 ATOM 72 CB ASN 10 34.406 41.428 -5.011 1.00
0.17 1SG 73 ATOM 73 CG ASN 10 35.623 41.693 -4.139 1.00 0.17 1SG 74
ATOM 74 OD1 ASN 10 35.830 41.018 -3.132 1.00 0.17 1SG 75 ATOM 75
ND2 ASN 10 36.451 42.698 -4.532 1.00 0.17 1SG 76 ATOM 76 C ASN 10
32.257 42.340 -5.702 1.00 0.17 1SG 77 ATOM 77 O ASN 10 31.543
41.346 -5.585 1.00 0.17 1SG 78 ATOM 78 N PRO 11 32.037 43.241
-6.615 1.00 0.35 1SG 79 ATOM 79 CA PRO 11 32.836 44.431 -6.695 1.00
0.35 1SG 80 ATOM 80 CD PRO 11 31.554 42.825 -7.923 1.00 0.35 1SG 81
ATOM 81 CB PRO 11 32.565 45.023 -8.076 1.00 0.35 1SG 82 ATOM 82 CG
PRO 11 32.180 43.803 -8.930 1.00 0.35 1SG 83 ATOM 83 C PRO 11
32.450 45.345 -5.579 1.00 0.35 1SG 84 ATOM 84 O PRO 11 31.441
45.098 -4.920 1.00 0.35 1SG 85 ATOM 85 N PRO 12 33.234 46.363
-5.359 1.00 0.52 1SG 86 ATOM 86 CA PRO 12 32.980 47.289 -4.289 1.00
0.52 1SG 87 ATOM 87 CD PRO 12 34.649 46.281 -5.684 1.00 0.52 1SG 88
ATOM 88 CB PRO 12 34.259 48.107 -4.134 1.00 0.52 1SG 89 ATOM 89 CG
PRO 12 35.360 47.165 -4.647 1.00 0.52 1SG 90 ATOM 90 C PRO 12
31.775 48.132 -4.544 1.00 0.52 1SG 91 ATOM 91 O PRO 12 31.347
48.837 -3.632 1.00 0.52 1SG 92 ATOM 92 N TRP 13 31.217 48.087
-5.767 1.00 0.35 1SG 93 ATOM 93 CA TRP 13 30.116 48.944 -6.099 1.00
0.35 1SG 94 ATOM 94 CB TRP 13 29.535 48.655 -7.492 1.00 0.35 1SG 95
ATOM 95 CG TRP 13 30.569 48.725 -8.590 1.00 0.35 1SG 96 ATOM 96 CD2
TRP 13 31.368 49.880 -8.883 1.00 0.35 1SG 97 ATOM 97 CD1 TRP 13
30.982 47.743 -9.442 1.00 0.35 1SG 98 ATOM 98 NE1 TRP 13 31.981
48.216 -10.257 1.00 0.35 1SG 99 ATOM 99 CE2 TRP 13 32.232 49.530
-9.921 1.00 0.35 1SG 100 ATOM 100 CE3 TRP 13 31.389 51.127 -8.327
1.00 0.35 1SG 101 ATOM 101 CZ2 TRP 13 33.131 50.426 -10.422 1.00
0.35 1SG 102 ATOM 102 CZ3 TRP 13 32.292 52.032 -8.839 1.00 0.35 1SG
103 ATOM 103 CH2 TRP 13 33.145 51.687 -9.867 1.00 0.35 1SG 104 ATOM
104 C TRP 13 29.028 48.729 -5.094 1.00 0.35 1SG 105 ATOM 105 O TRP
13 28.536 47.615 -4.920 1.00 0.35 1SG 106 ATOM 106 N ASN 14 28.646
49.808 -4.379 1.00 0.15 1SG 107 ATOM 107 CA ASN 14 27.615 49.722
-3.385 1.00 0.15 1SG 108 ATOM 108 CB ASN 14 27.490 50.980 -2.504
1.00 0.15 1SG 109 ATOM 109 CG ASN 14 26.978 52.146 -3.340 1.00 0.15
1SG 110 ATOM 110 OD1 ASN 14 27.409 52.366 -4.471 1.00 0.15 1SG 111
ATOM 111 ND2 ASN 14 26.008 52.913 -2.773 1.00 0.15 1SG 112 ATOM 112
C ASN 14 26.300 49.521 -4.065 1.00 0.15 1SG 113 ATOM 113 O ASN 14
25.463 48.747 -3.602 1.00 0.15 1SG 114 ATOM 114 N ARG 15 26.087
50.221 -5.196 1.00 0.13 1SG 115 ATOM 115 CA ARG 15 24.834 50.135
-5.884 1.00 0.13 1SG 116 ATOM 116 CB ARG 15 24.365 51.472 -6.487
1.00 0.13 1SG 117 ATOM 117 CG ARG 15 24.050 52.558 -5.458 1.00 0.13
1SG 118 ATOM 118 CD ARG 15 23.590 53.872 -6.094 1.00 0.13 1SG 119
ATOM 119 NE ARG 15 23.349 54.844 -4.990 1.00 0.13 1SG 120 ATOM 120
CZ ARG 15 22.138 55.461 -4.864 1.00 0.13 1SG 121 ATOM 121 NH1 ARG
15 21.143 55.212 -5.764 1.00 0.13 1SG 122 ATOM 122 NH2 ARG 15
21.924 56.330 -3.833 1.00 0.13 1SG 123 ATOM 123 C ARG 15 25.033
49.218 -7.039 1.00 0.13 1SG 124 ATOM 124 O ARG 15 25.976 49.374
-7.813 1.00 0.13 1SG 125 ATOM 125 N ILE 16 24.144 48.220 -7.185
1.00 0.12 1SG 126 ATOM 126 CA ILE 16 24.295 47.330 -8.294 1.00 0.12
1SG 127 ATOM 127 CB ILE 16 24.817 45.969 -7.928 1.00 0.12 1SG 128
ATOM 128 CG2 ILE 16 26.224 46.139 -7.331 1.00 0.12 1SG 129 ATOM 129
CG1 ILE 16 23.828 45.237 -7.005 1.00 0.12 1SG 130 ATOM 130 CD1 ILE
16 24.141 43.749 -6.850 1.00 0.12 1SG 131 ATOM 131 C ILE 16 22.948
47.120 -8.892 1.00 0.12 1SG 132 ATOM 132 O ILE 16 21.939 47.597
-8.374 1.00 0.12 1SG 133 ATOM 133 N PHE 17 22.919 46.404 -10.030
1.00 0.17 1SG 134 ATOM 134 CA PHE 17 21.684 46.108 -10.688 1.00
0.17 1SG 135 ATOM 135 CB PHE 17 21.755 46.075 -12.223 1.00 0.17 1SG
136 ATOM 136 CG PHE 17 21.919 47.447 -12.765 1.00 0.17 1SG 137 ATOM
137 CD1 PHE 17 20.844 48.303 -12.811 1.00 0.17 1SG 138 ATOM 138 CD2
PHE 17 23.137 47.862 -13.248 1.00 0.17 1SG 139 ATOM 139 CE1 PHE 17
20.984 49.568 -13.324 1.00 0.17 1SG 140 ATOM 140 CE2 PHE 17 23.283
49.126 -13.764 1.00 0.17 1SG 141 ATOM 141 CZ PHE 17 22.205 49.976
-13.800 1.00 0.17 1SG 142 ATOM 142 C PHE 17 21.314 44.719 -10.316
1.00 0.17 1SG 143 ATOM 143 O PHE 17 22.151 43.922 -9.896 1.00 0.17
1SG 144 ATOM 144 N LYS 18 20.018 44.402 -10.462 1.00 0.22 1SG 145
ATOM 145 CA LYS 18 19.571 43.082 -10.162 1.00 0.22 1SG 146 ATOM 146
CB LYS 18 18.040 42.943 -10.187 1.00 0.22 1SG 147 ATOM 147 CG LYS
18 17.424 43.301 -11.539 1.00 0.22 1SG 148 ATOM 148 CD LYS 18
15.961 42.882 -11.672 1.00 0.22 1SG 149 ATOM 149 CE LYS 18 15.353
43.196 -13.039 1.00 0.22 1SG 150 ATOM 150 NZ LYS 18 14.014 42.574
-13.142 1.00 0.22 1SG 151 ATOM 151 C LYS 18 20.141 42.189 -11.210
1.00 0.22 1SG 152 ATOM 152 O LYS 18 20.335 42.596 -12.355 1.00 0.22
1SG 153 ATOM 153 N GLY 19 20.455 40.940 -10.824 1.00 0.21 1SG 154
ATOM 154 CA GLY 19 20.986 40.005 -11.767 1.00 0.21 1SG 155 ATOM 155
C GLY 19 22.474 40.059 -11.692 1.00 0.21 1SG 156 ATOM 156 O GLY 19
23.160 39.196 -12.236 1.00 0.21 1SG 157 ATOM 157 N GLU 20 23.017
41.079 -11.005 1.00 0.23 1SG 158 ATOM 158 CA GLU 20 24.442 41.177
-10.910 1.00 0.23 1SG 159 ATOM 159 CB GLU 20 24.940 42.579 -10.523
1.00 0.23 1SG 160 ATOM 160 CG GLU 20 24.680 43.613 -11.619 1.00
0.23 1SG 161 ATOM 161 CD GLU 20 25.391 43.115 -12.870 1.00 0.23 1SG
162 ATOM 162 OE1 GLU 20 26.556 42.653 -12.741 1.00 0.23 1SG 163
ATOM 163 OE2 GLU 20 24.774 43.175 -13.967 1.00 0.23 1SG 164 ATOM
164 C GLU 20 24.897 40.218 -9.864 1.00 0.23 1SG 165 ATOM 165 O GLU
20 24.122 39.806 -9.001 1.00 0.23 1SG 166 ATOM 166 N ASN 21 26.181
39.822 -9.930 1.00 0.16 1SG 167 ATOM 167 CA ASN 21 26.694 38.898
-8.965 1.00 0.16 1SG 168 ATOM 168 CB ASN 21 27.686 37.880 -9.553
1.00 0.16 1SG 169 ATOM 169 CG ASN 21 26.895 36.971 -10.481 1.00
0.16 1SG 170 ATOM 170 OD1 ASN 21 25.671 36.909 -10.394 1.00 0.16
1SG 171 ATOM 171 ND2 ASN 21 27.602 36.251 -11.392 1.00 0.16 1SG 172
ATOM 172 C ASN 21 27.415 39.694 -7.933 1.00 0.16 1SG 173 ATOM 173 O
ASN 21 28.121 40.652 -8.246 1.00 0.16 1SG 174 ATOM 174 N VAL 22
27.217 39.327 -6.654 1.00 0.07 1SG 175 ATOM 175 CA VAL 22 27.876
40.026 -5.596 1.00 0.07 1SG 176 ATOM 176 CB VAL 22 26.922 40.670
-4.632 1.00 0.07 1SG 177 ATOM 177 CG1 VAL 22 27.727 41.288 -3.478
1.00 0.07 1SG 178 ATOM 178 CG2 VAL 22 26.056 41.681 -5.405 1.00
0.07 1SG 179 ATOM 179 C VAL 22 28.661 39.015 -4.836 1.00 0.07 1SG
180 ATOM 180 O VAL 22 28.186 37.907 -4.590 1.00 0.07 1SG 181 ATOM
181 N THR 23 29.908 39.362 -4.469 1.00 0.06 1SG 182 ATOM 182 CA THR
23 30.692 38.440 -3.706 1.00 0.06 1SG 183 ATOM 183 CB THR 23 31.980
38.047 -4.368 1.00 0.06 1SG 184 ATOM 184 OG1 THR 23 31.714 37.430
-5.619 1.00 0.06 1SG 185 ATOM 185 CG2 THR 23 32.727 37.067 -3.446
1.00 0.06 1SG 186 ATOM 186 C THR 23 31.044 39.117 -2.425 1.00 0.06
1SG 187 ATOM 187 O THR 23 31.577 40.225 -2.418 1.00 0.06 1SG 188
ATOM 188 N LEU 24 30.731 38.460 -1.295 1.00 0.06 1SG 189 ATOM 189
CA LEU 24 31.057 39.021 -0.020 1.00 0.06 1SG 190 ATOM 190 CB LEU 24
29.871 39.048 0.956 1.00 0.06 1SG 191 ATOM 191 CG LEU 24 28.702
39.930 0.479 1.00 0.06 1SG 192 ATOM 192 CD2 LEU 24 29.182 41.346
0.123 1.00 0.06 1SG 193 ATOM 193 CD1 LEU 24 27.548 39.924 1.495
1.00 0.06 1SG 194 ATOM 194 C LEU 24 32.076 38.112 0.572 1.00 0.06
1SG 195 ATOM 195 O LEU 24 31.886 36.898 0.615 1.00 0.06 1SG 196
ATOM 196 N THR 25 33.206 38.678 1.030 1.00 0.28 1SG 197 ATOM 197 CA
THR 25 34.202 37.838 1.616 1.00 0.28 1SG 198 ATOM 198 CB THR 25
35.507 37.852 0.876 1.00 0.28 1SG 199 ATOM 199 OG1 THR 25 35.319
37.412 -0.461 1.00 0.28 1SG 200 ATOM 200 CG2 THR 25 36.496 36.927
1.605 1.00 0.28 1SG 201 ATOM 201 C THR 25 34.460 38.367 2.979 1.00
0.28 1SG 202 ATOM 202 O THR 25 34.579 39.572 3.187 1.00 0.28 1SG
203 ATOM 203 N CYS 26 34.543 37.462 3.960 1.00 0.52 1SG 204 ATOM
204 CA CYS 26 34.770 37.922 5.286 1.00 0.52 1SG 205 ATOM 205 CB CYS
26 33.724 37.332 6.226 1.00 0.52 1SG 206 ATOM 206 SG CYS 26 33.905
37.844 7.940 1.00 0.52 1SG 207 ATOM 207 C CYS 26 36.111 37.410
5.681 1.00 0.52 1SG 208 ATOM 208 O CYS 26 36.327 36.201 5.748 1.00
0.52 1SG 209 ATOM 209 N ASN 27 37.050 38.332 5.961 1.00 0.35 1SG
210 ATOM 210 CA ASN 27 38.377 37.918 6.298 1.00 0.35 1SG 211 ATOM
211 CB ASN 27 39.472 38.673 5.527 1.00 0.35 1SG 212 ATOM 212 CG ASN
27 39.389 40.140 5.927 1.00 0.35 1SG 213 ATOM 213 OD1 ASN 27 38.320
40.747 5.897 1.00 0.35 1SG 214 ATOM 214 ND2 ASN 27 40.549 40.726
6.326 1.00 0.35 1SG 215 ATOM 215 C ASN 27 38.595 38.211 7.743 1.00
0.35 1SG 216 ATOM 216 O ASN 27 37.972 39.107 8.310 1.00 0.35 1SG
217 ATOM 217 N GLY 28 39.483 37.427 8.381 1.00 0.15 1SG 218 ATOM
218 CA GLY 28 39.779 37.636 9.765 1.00 0.15 1SG 219 ATOM 219 C GLY
28 40.251 36.330 10.306 1.00 0.15 1SG 220 ATOM 220 O GLY 28 40.302
35.333 9.587 1.00 0.15 1SG 221 ATOM 221 N ASN 29 40.604 36.299
11.606 1.00 0.16 1SG 222 ATOM 222 CA ASN 29 41.053 35.065 12.173
1.00 0.16 1SG 223 ATOM 223 CB ASN 29 41.554 35.176 13.624 1.00 0.16
1SG 224 ATOM 224 CG ASN 29 42.895 35.895 13.621 1.00 0.16 1SG 225
ATOM 225 OD1 ASN 29 43.494 36.131 12.573 1.00 0.16 1SG 226 ATOM 226
ND2 ASN 29 43.391 36.241 14.838 1.00 0.16 1SG 227 ATOM 227 C ASN 29
39.883 34.143 12.168 1.00 0.16 1SG 228 ATOM 228 O ASN 29 38.741
34.566 12.336 1.00 0.16 1SG 229 ATOM 229 N ASN 30 40.148 32.843
11.949 1.00 0.16 1SG 230 ATOM 230 CA ASN 30 39.080 31.893 11.889
1.00 0.16 1SG 231 ATOM 231 CB ASN 30 38.855 31.359 10.468 1.00 0.16
1SG 232 ATOM 232 CG ASN 30 37.718 30.355 10.511 1.00 0.16 1SG 233
ATOM 233 OD1 ASN 30 36.716 30.535 11.200 1.00 0.16 1SG 234 ATOM 234
ND2 ASN 30 37.899 29.239 9.758 1.00 0.16 1SG 235 ATOM 235 C ASN 30
39.436 30.721 12.744 1.00 0.16 1SG 236 ATOM 236 O ASN 30 40.609
30.390 12.909 1.00 0.16 1SG 237 ATOM 237 N PHE 31 38.409 30.073
13.332 1.00 0.12 1SG 238 ATOM 238 CA PHE 31 38.628 28.899 14.123
1.00 0.12 1SG 239 ATOM 239 CB PHE 31 37.510 28.639 15.146 1.00 0.12
1SG 240 ATOM 240 CG PHE 31 37.857 27.404 15.902 1.00 0.12 1SG 241
ATOM 241 CD1 PHE 31 38.774 27.447 16.927 1.00 0.12 1SG 242 ATOM 242
CD2 PHE 31 37.260 26.205 15.592 1.00 0.12 1SG 243 ATOM 243 CE1 PHE
31 39.092 26.310 17.631 1.00 0.12 1SG 244 ATOM 244 CE2 PHE 31
37.575 25.064 16.292 1.00 0.12 1SG 245 ATOM 245 CZ PHE 31 38.495
25.115 17.312 1.00 0.12 1SG 246 ATOM 246 C PHE 31 38.639 27.765
13.155 1.00 0.12 1SG 247 ATOM 247 O PHE 31 38.118 27.888 12.049
1.00 0.12 1SG 248 ATOM 248 N PHE 32 39.248 26.626 13.528 1.00 0.11
1SG 249 ATOM 249 CA PHE 32 39.265 25.565 12.570 1.00 0.11 1SG 250
ATOM 250 CS PHE 32 40.426 24.579 12.773 1.00 0.11 1SG 251 ATOM 251
CG PHE 32 41.663 25.381 12.563 1.00 0.11 1SG 252 ATOM 252 CD1 PHE
32 42.195 26.109 13.602 1.00 0.11 1SG 253 ATOM 253 CD2 PHE 32
42.284 25.417 11.337 1.00 0.11 1SG 254 ATOM 254 CE1 PHE 32 43.335
26.857 13.428 1.00 0.11 1SG 255 ATOM 255 CE2 PHE 32 43.424 26.164
11.157 1.00 0.11 1SG 256 ATOM 256 CZ PHE 32 43.952 26.885 12.201
1.00 0.11 1SG 257 ATOM 257 C PHE 32 37.980 24.827 12.710 1.00 0.11
1SG 258 ATOM 258 O PHE 32 37.879 23.858 13.460 1.00 0.11 1SG 259
ATOM 259 N GLU 33 36.949 25.287 11.977 1.00 0.10 1SG 260 ATOM 260
CA GLU 33 35.673 24.643 12.038 1.00 0.10 1SG 261 ATOM 261 CB GLU 33
34.682 25.327 12.994 1.00 0.10 1SG 262 ATOM 262 CG GLU 33 34.364
26.773 12.610 1.00 0.10 1SG 263 ATOM 263 CD GLU 33 33.383 27.314
13.638 1.00 0.10 1SG 264 ATOM 264 OE1 GLU 33 32.437 26.565 13.999
1.00 0.10 1SG 265 ATOM 265 OE2 GLU 33 33.567 28.481 14.077 1.00
0.10 1SG 266 ATOM 266 C GLU 33 35.076 24.698 10.672 1.00 0.10 1SG
267 ATOM 267 O GLU 33 35.453 25.532 9.849 1.00 0.10 1SG 268 ATOM
268 N VAL 34 34.130 23.784 10.391 1.00 0.09 1SG 269 ATOM 269 CA VAL
34 33.509 23.763 9.103 1.00 0.09 1SG 270 ATOM 270 CB VAL 34 32.562
22.612 8.943 1.00 0.09 1SG 271 ATOM 271 CG1 VAL 34 31.945 22.676
7.538 1.00 0.09 1SG 272 ATOM 272 CG2 VAL 34 33.335 21.310 9.215
1.00 0.09 1SG 273 ATOM 273 C VAL 34 32.742 25.032 8.926 1.00 0.09
1SG 274 ATOM 274 O VAL 34 32.854 25.693 7.895 1.00 0.09 1SG 275
ATOM 275 N SER 35 31.953 25.431 9.942 1.00 0.11 1SG 276 ATOM 276 CA
SER 35 31.202 26.645 9.800 1.00 0.11 1SG 277 ATOM 277 CB SER 35
29.838 26.613 10.522 1.00 0.11 1SG 278 ATOM 278 OG SER 35 30.011
26.400 11.915 1.00 0.11 1SG 279 ATOM 279 C SER 35 32.033 27.743
10.378 1.00 0.11 1SG 280 ATOM 280 O SER 35 31.856 28.153 11.524
1.00 0.11 1SG 281 ATOM 281 N SER 36 32.974 28.249 9.563
1.00 0.27 1SG 282 ATOM 282 CA SER 36 33.906 29.251 9.984 1.00 0.27
1SG 283 ATOM 283 CB SER 36 34.962 29.539 8.905 1.00 0.27 1SG 284
ATOM 284 OG SER 36 35.648 28.343 8.571 1.00 0.27 1SG 285 ATOM 285 C
SER 36 33.204 30.541 10.256 1.00 0.27 1SG 286 ATOM 286 O SER 36
33.439 31.186 11.277 1.00 0.27 1SG 287 ATOM 287 N THR 37 32.290
30.954 9.360 1.00 0.48 1SG 288 ATOM 288 CA THR 37 31.752 32.266
9.550 1.00 0.48 1SG 289 ATOM 289 CB THR 37 32.132 33.216 8.462 1.00
0.48 1SG 290 ATOM 290 OG1 THR 37 31.579 34.490 8.737 1.00 0.48 1SG
291 ATOM 291 CG2 THR 37 31.591 32.685 7.124 1.00 0.48 1SG 292 ATOM
292 C THR 37 30.265 32.253 9.596 1.00 0.48 1SG 293 ATOM 293 O THR
37 29.607 31.337 9.105 1.00 0.48 1SG 294 ATOM 294 N LYS 38 29.708
33.307 10.225 1.00 0.41 1SG 295 ATOM 295 CA LYS 38 28.291 33.482
10.294 1.00 0.41 1SG 296 ATOM 296 CB LYS 38 27.770 33.754 11.715
1.00 0.41 1SG 297 ATOM 297 CG LYS 38 28.245 32.739 12.757 1.00 0.41
1SG 298 ATOM 298 CD LYS 38 29.734 32.877 13.087 1.00 0.41 1SG 299
ATOM 299 CE LYS 38 30.193 32.030 14.276 1.00 0.41 1SG 300 ATOM 300
NZ LYS 38 31.621 32.301 14.565 1.00 0.41 1SG 301 ATOM 301 C LYS 38
28.013 34.720 9.506 1.00 0.41 1SG 302 ATOM 302 O LYS 38 28.709
35.726 9.652 1.00 0.41 1SG 303 ATOM 303 N TRP 39 26.998 34.677
8.624 1.00 0.18 1SG 304 ATOM 304 CA TRP 39 26.680 35.852 7.870 1.00
0.18 1SG 305 ATOM 305 CB TRP 39 26.599 35.645 6.344 1.00 0.18 1SG
306 ATOM 306 CG TRP 39 27.940 35.495 5.663 1.00 0.18 1SG 307 ATOM
307 CD2 TRP 39 28.804 36.606 5.377 1.00 0.18 1SG 308 ATOM 308 CD1
TRP 39 28.585 34.378 5.220 1.00 0.18 1SG 309 ATOM 309 NE1 TRP 39
29.800 34.725 4.672 1.00 0.18 1SG 310 ATOM 310 CE2 TRP 39 29.947
36.094 4.764 1.00 0.18 1SG 311 ATOM 311 CE3 TRP 39 28.656 37.943
5.611 1.00 0.18 1SG 312 ATOM 312 CZ2 TRP 39 30.964 36.918 4.374
1.00 0.18 1SG 313 ATOM 313 CZ3 TRP 39 29.681 38.772 5.214 1.00 0.18
1SG 314 ATOM 314 CH2 TRP 39 30.813 38.269 4.607 1.00 0.18 1SG 315
ATOM 315 C TRP 39 25.345 36.329 8.319 1.00 0.18 1SG 316 ATOM 316 O
TRP 39 24.473 35.536 8.668 1.00 0.18 1SG 317 ATOM 317 N PHE 40
25.166 37.662 8.355 1.00 0.08 1SG 318 ATOM 318 CA PHE 40 23.898
38.177 8.759 1.00 0.08 1SG 319 ATOM 319 CB PHE 40 23.942 38.924
10.102 1.00 0.08 1SG 320 ATOM 320 CG PHE 40 24.268 37.911 11.142
1.00 0.08 1SG 321 ATOM 321 CD1 PHE 40 25.575 37.560 11.393 1.00
0.08 1SG 322 ATOM 322 CD2 PHE 40 23.262 37.311 11.865 1.00 0.08 1SG
323 ATOM 323 CE1 PHE 40 25.872 36.623 12.352 1.00 0.08 1SG 324 ATOM
324 CE2 PHE 40 23.555 36.372 12.826 1.00 0.08 1SG 325 ATOM 325 CZ
PHE 40 24.863 36.028 13.071 1.00 0.08 1SG 326 ATOM 326 C PHE 40
23.449 39.146 7.721 1.00 0.08 1SG 327 ATOM 327 O PHE 40 24.243
39.920 7.189 1.00 0.08 1SG 328 ATOM 328 N HIS 41 22.150 39.090
7.382 1.00 0.10 1SG 329 ATOM 329 CA HIS 41 21.589 40.033 6.468 1.00
0.10 1SG 330 ATOM 330 ND1 HIS 41 19.882 40.132 3.044 1.00 0.10 1SG
331 ATOM 331 CG HIS 41 20.491 40.427 4.242 1.00 0.10 1SG 332 ATOM
332 CB HIS 41 20.942 39.397 5.232 1.00 0.10 1SG 333 ATOM 333 NE2
HIS 41 20.036 42.349 3.153 1.00 0.10 1SG 334 ATOM 334 CD2 HIS 41
20.577 41.784 4.294 1.00 0.10 1SG 335 ATOM 335 CE1 HIS 41 19.631
41.317 2.434 1.00 0.10 1SG 336 ATOM 336 C HIS 41 20.508 40.722
7.226 1.00 0.10 1SG 337 ATOM 337 O HIS 41 19.557 40.090 7.682 1.00
0.10 1SG 338 ATOM 338 N ASN 42 20.632 42.049 7.386 1.00 0.11 1SG
339 ATOM 339 CA ASN 42 19.651 42.772 8.132 1.00 0.11 1SG 340 ATOM
340 CB ASN 42 18.252 42.764 7.489 1.00 0.11 1SG 341 ATOM 341 CG ASN
42 18.291 43.691 6.283 1.00 0.11 1SG 342 ATOM 342 OD1 ASN 42 19.275
44.395 6.062 1.00 0.11 1SG 343 ATOM 343 ND2 ASN 42 17.185 43.710
5.492 1.00 0.11 1SG 344 ATOM 344 C ASN 42 19.566 42.155 9.490 1.00
0.11 1SG 345 ATOM 345 O ASN 42 18.525 42.200 10.144 1.00 0.11 1SG
346 ATOM 346 N GLY 43 20.683 41.567 9.955 1.00 0.08 1SG 347 ATOM
347 CA GLY 43 20.714 41.014 11.277 1.00 0.08 1SG 348 ATOM 348 C GLY
43 20.172 39.620 11.264 1.00 0.08 1SG 349 ATOM 349 O GLY 43 20.036
39.001 12.318 1.00 0.08 1SG 350 ATOM 350 N SER 44 19.844 39.074
10.079 1.00 0.15 1SG 351 ATOM 351 CA SER 44 19.330 37.735 10.068
1.00 0.15 1SG 352 ATOM 352 CB SER 44 18.218 37.498 9.034 1.00 0.15
1SG 353 ATOM 353 OG SER 44 18.737 37.641 7.720 1.00 0.15 1SG 354
ATOM 354 C SER 44 20.464 36.832 9.717 1.00 0.15 1SG 355 ATOM 355 O
SER 44 21.203 37.085 8.769 1.00 0.15 1SG 356 ATOM 356 N LEU 45
20.638 35.747 10.491 1.00 0.35 1SG 357 ATOM 357 CA LEU 45 21.720
34.843 10.241 1.00 0.35 1SG 358 ATOM 358 CB LEU 45 21.939 33.852
11.413 1.00 0.35 1SG 359 ATOM 359 CG LEU 45 23.091 32.823 11.298
1.00 0.35 1SG 360 ATOM 360 CD2 LEU 45 22.938 31.865 10.100 1.00
0.35 1SG 361 ATOM 361 CD1 LEU 45 23.226 32.022 12.602 1.00 0.35 1SG
362 ATOM 362 C LEU 45 21.398 34.097 8.988 1.00 0.35 1SG 363 ATOM
363 O LEU 45 20.249 33.736 8.740 1.00 0.35 1SG 364 ATOM 364 N SER
46 22.430 33.863 8.153 1.00 0.48 1SG 365 ATOM 365 CA SER 46 22.263
33.118 6.938 1.00 0.48 1SG 366 ATOM 366 CB SER 46 22.957 33.730
5.707 1.00 0.48 1SG 367 ATOM 367 OG SER 46 22.355 34.958 5.334 1.00
0.48 1SG 368 ATOM 368 C SER 46 22.960 31.813 7.135 1.00 0.48 1SG
369 ATOM 369 O SER 46 24.137 31.770 7.487 1.00 0.48 1SG 370 ATOM
370 N GLU 47 22.221 30.711 6.936 1.00 0.44 1SG 371 ATOM 371 CA GLU
47 22.724 29.371 7.017 1.00 0.44 1SG 372 ATOM 372 CB GLU 47 21.604
28.321 7.026 1.00 0.44 1SG 373 ATOM 373 CG GLU 47 20.768 28.350
5.745 1.00 0.44 1SG 374 ATOM 374 CD GLU 47 19.700 27.272 5.839 1.00
0.44 1SG 375 ATOM 375 OE1 GLU 47 19.539 26.690 6.945 1.00 0.44 1SG
376 ATOM 376 OE2 GLU 47 19.030 27.016 4.803 1.00 0.44 1SG 377 ATOM
377 C GLU 47 23.552 29.092 5.800 1.00 0.44 1SG 378 ATOM 378 O GLU
47 24.413 28.215 5.800 1.00 0.44 1SG 379 ATOM 379 N GLU 48 23.288
29.858 4.730 1.00 0.45 1SG 380 ATOM 380 CA GLU 48 23.741 29.635
3.387 1.00 0.45 1SG 381 ATOM 381 CB GLU 48 23.284 30.775 2.465 1.00
0.45 1SG 382 ATOM 382 CG GLU 48 23.798 32.140 2.929 1.00 0.45 1SG
383 ATOM 383 CD GLU 48 23.187 33.215 2.041 1.00 0.45 1SG 384 ATOM
384 OE1 GLU 48 22.440 32.852 1.094 1.00 0.45 1SG 385 ATOM 385 OE2
GLU 48 23.459 34.417 2.302 1.00 0.45 1SG 386 ATOM 386 C GLU 48
25.226 29.496 3.195 1.00 0.45 1SG 387 ATOM 387 O GLU 48 25.647
28.553 2.528 1.00 0.45 1SG 388 ATOM 388 N THR 49 26.087 30.365
3.758 1.00 0.55 1SG 389 ATOM 389 CA THR 49 27.427 30.251 3.247 1.00
0.55 1SG 390 ATOM 390 CB THR 49 27.684 31.331 2.235 1.00 0.55 1SG
391 ATOM 391 OG1 THR 49 28.936 31.166 1.589 1.00 0.55 1SG 392 ATOM
392 CG2 THR 49 27.629 32.679 2.968 1.00 0.55 1SG 393 ATOM 393 C THR
49 28.482 30.361 4.310 1.00 0.55 1SG 394 ATOM 394 O THR 49 28.213
30.658 5.473 1.00 0.55 1SG 395 ATOM 395 N ASN 50 29.736 30.090
3.881 1.00 0.44 1SG 396 ATOM 396 CA ASN 50 30.937 30.109 4.665 1.00
0.44 1SG 397 ATOM 397 CB ASN 50 31.925 28.990 4.291 1.00 0.44 1SG
398 ATOM 398 CG ASN 50 31.335 27.665 4.747 1.00 0.44 1SG 399 ATOM
399 OD1 ASN 50 31.044 27.481 5.927 1.00 0.44 1SG 400 ATOM 400 ND2
ASN 50 31.153 26.715 3.790 1.00 0.44 1SG 401 ATOM 401 C ASN 50
31.648 31.407 4.437 1.00 0.44 1SG 402 ATOM 402 O ASN 50 31.038
32.472 4.355 1.00 0.44 1SG 403 ATOM 403 N SER 51 32.990 31.325
4.329 1.00 0.25 1SG 404 ATOM 404 CA SER 51 33.843 32.473 4.237 1.00
0.25 1SG 405 ATOM 405 CB SER 51 35.323 32.099 4.049 1.00 0.25 1SG
406 ATOM 406 OG SER 51 35.506 31.465 2.792 1.00 0.25 1SG 407 ATOM
407 C SER 51 33.455 33.328 3.073 1.00 0.25 1SG 408 ATOM 408 O SER
51 33.338 34.545 3.215 1.00 0.25 1SG 409 ATOM 409 N SER 52 33.234
32.733 1.887 1.00 0.14 1SG 410 ATOM 410 CA SER 52 32.906 33.575
0.772 1.00 0.14 1SG 411 ATOM 411 CB SER 52 33.750 33.288 -0.481
1.00 0.14 1SG 412 ATOM 412 OG SER 52 35.116 33.578 -0.227 1.00 0.14
1SG 413 ATOM 413 C SER 52 31.480 33.343 0.406 1.00 0.14 1SG 414
ATOM 414 O SER 52 31.035 32.204 0.274 1.00 0.14 1SG 415 ATOM 415 N
LEU 53 30.709 34.437 0.251 1.00 0.09 1SG 416 ATOM 416 CA LEU 53
29.346 34.271 -0.150 1.00 0.09 1SG 417 ATOM 417 CB LEU 53 28.319
34.889 0.816 1.00 0.09 1SG 418 ATOM 418 CG LEU 53 26.856 34.696
0.368 1.00 0.09 1SG 419 ATOM 419 CD2 LEU 53 25.893 35.495 1.259
1.00 0.09 1SG 420 ATOM 420 CD1 LEU 53 26.482 33.208 0.298 1.00 0.09
1SG 421 ATOM 421 C LEU 53 29.195 34.941 -1.473 1.00 0.09 1SG 422
ATOM 422 O LEU 53 29.476 36.130 -1.619 1.00 0.09 1SG 423 ATOM 423 N
ASN 54 28.760 34.174 -2.488 1.00 0.09 1SG 424 ATOM 424 CA ASN 54
28.584 34.749 -3.786 1.00 0.09 1SG 425 ATOM 425 CB ASN 54 29.349
34.011 -4.897 1.00 0.09 1SG 426 ATOM 426 CG ASN 54 29.234 34.837
-6.169 1.00 0.09 1SG 427 ATOM 427 OD1 ASN 54 28.770 35.975 -6.145
1.00 0.09 1SG 428 ATOM 428 ND2 ASN 54 29.658 34.244 -7.317 1.00
0.09 1SG 429 ATOM 429 C ASN 54 27.137 34.629 -4.118 1.00 0.09 1SG
430 ATOM 430 O ASN 54 26.544 33.562 -3.972 1.00 0.09 1SG 431 ATOM
431 N ILE 55 26.522 35.736 -4.566 1.00 0.08 1SG 432 ATOM 432 CA ILE
55 25.141 35.665 -4.922 1.00 0.08 1SG 433 ATOM 433 CB ILE 55 24.258
36.575 -4.120 1.00 0.08 1SG 434 ATOM 434 CG2 ILE 55 24.346 36.152
-2.644 1.00 0.08 1SG 435 ATOM 435 CG1 ILE 55 24.636 38.044 -4.369
1.00 0.08 1SG 436 ATOM 436 CD1 ILE 55 23.600 39.030 -3.832 1.00
0.08 1SG 437 ATOM 437 C ILE 55 25.039 36.115 -6.337 1.00 0.08 1SG
438 ATOM 438 O ILE 55 25.773 36.998 -6.779 1.00 0.08 1SG 439 ATOM
439 N VAL 56 24.119 35.493 -7.090 1.00 0.10 1SG 440 ATOM 440 CA VAL
56 23.922 35.858 -8.456 1.00 0.10 1SG 441 ATOM 441 CB VAL 56 23.985
34.683 -9.389 1.00 0.10 1SG 442 ATOM 442 CG1 VAL 56 23.615 35.140
-10.810 1.00 0.10 1SG 443 ATOM 443 CG2 VAL 56 25.383 34.050 -9.280
1.00 0.10 1SG 444 ATOM 444 C VAL 56 22.544 36.412 -8.532 1.00 0.10
1SG 445 ATOM 445 O VAL 56 21.686 36.071 -7.719 1.00 0.10 1SG 446
ATOM 446 N ASN 57 22.312 37.292 -9.523 1.00 0.11 1SG 447 ATOM 447
CA ASN 57 21.035 37.906 -9.706 1.00 0.11 1SG 448 ATOM 448 CB ASN 57
19.953 36.958 -10.250 1.00 0.11 1SG 449 ATOM 449 CG ASN 57 18.801
37.822 -10.747 1.00 0.11 1SG 450 ATOM 450 OD1 ASN 57 18.420 38.801
-10.107 1.00 0.11 1SG 451 ATOM 451 ND2 ASN 57 18.239 37.461 -11.932
1.00 0.11 1SG 452 ATOM 452 C ASN 57 20.576 38.473 -8.404 1.00 0.11
1SG 453 ATOM 453 O ASN 57 19.548 38.066 -7.865 1.00 0.11 1SG 454
ATOM 454 N ALA 58 21.353 39.425 -7.850 1.00 0.21 1SG 455 ATOM 455
CA ALA 58 20.945 40.022 -6.615 1.00 0.21 1SG 456 ATOM 456 CB ALA 58
21.884 41.136 -6.118 1.00 0.21 1SG 457 ATOM 457 C ALA 58 19.608
40.631 -6.871 1.00 0.21 1SG 458 ATOM 458 O ALA 58 19.393 41.275
-7.897 1.00 0.21 1SG 459 ATOM 459 N LYS 59 18.660 40.414 -5.941
1.00 0.31 1SG 460 ATOM 460 CA LYS 59 17.329 40.910 -6.123 1.00 0.31
1SG 461 ATOM 461 CB LYS 59 16.237 39.929 -5.664 1.00 0.31 1SG 462
ATOM 462 CG LYS 59 16.172 38.657 -6.511 1.00 0.31 1SG 463 ATOM 463
CD LYS 59 15.844 38.913 -7.985 1.00 0.31 1SG 464 ATOM 464 CE LYS 59
15.812 37.638 -8.834 1.00 0.31 1SG 465 ATOM 465 NZ LYS 59 15.485
37.972 -10.239 1.00 0.31 1SG 466 ATOM 466 C LYS 59 17.157 42.162
-5.331 1.00 0.31 1SG 467 ATOM 467 O LYS 59 18.068 42.622 -4.645
1.00 0.31 1SG 468 ATOM 468 N PHE 60 15.948 42.746 -5.431 1.00 0.23
1SG 469 ATOM 469 CA PHE 60 15.595 43.928 -4.704 1.00 0.23 1SG 470
ATOM 470 CB PHE 60 14.165 44.410 -4.999 1.00 0.23 1SG 471 ATOM 471
CG PHE 60 13.854 45.482 -4.011 1.00 0.23 1SG 472 ATOM 472 CD1 PHE
60 14.289 46.773 -4.202 1.00 0.23 1SG 473 ATOM 473 CD2 PHE 60
13.119 45.189 -2.885 1.00 0.23 1SG 474 ATOM 474 CE1 PHE 60 13.998
47.753 -3.282 1.00 0.23 1SG 475 ATOM 475 CE2 PHE 60 12.825 46.165
-1.962 1.00 0.23 1SG 476 ATOM 476 CZ PHE 60 13.264 47.451 -2.161
1.00 0.23 1SG 477 ATOM 477 C PHE 60 15.656 43.581 -3.255 1.00 0.23
1SG 478 ATOM 478 O PHE 60 16.056 44.387 -2.417 1.00 0.23 1SG 479
ATOM 479 N GLU 61 15.265 42.337 -2.942 1.00 0.15 1SG 480 ATOM 480
CA GLU 61 15.215 41.816 -1.609 1.00 0.15 1SG 481 ATOM 481 CB GLU 61
14.699 40.370 -1.604 1.00 0.15 1SG 482 ATOM 482 CG GLU 61 15.521
39.448 -2.507 1.00 0.15 1SG 483 ATOM 483 CD GLU 61 14.713 38.185
-2.765 1.00 0.15 1SG 484 ATOM 484 OE1 GLU 61 14.026 37.714 -1.820
1.00 0.15 1SG 485 ATOM 485 OE2 GLU 61 14.761 37.681 -3.919 1.00
0.15 1SG 486 ATOM 486 C GLU 61 16.595 41.837 -1.028 1.00 0.15 1SG
487 ATOM 487 O GLU 61 16.769 42.050 0.170 1.00 0.15 1SG 488 ATOM
488 N ASP 62 17.618 41.636 -1.877 1.00 0.16 1SG 489 ATOM 489 CA ASP
62 18.983 41.538 -1.440 1.00 0.16 1SG 490 ATOM 490 CB ASP 62 19.962
41.211 -2.582 1.00 0.16 1SG 491 ATOM 491 CG ASP 62 19.751 39.749
-2.954 1.00 0.16 1SG 492 ATOM 492 OD1 ASP 62 18.944 39.075 -2.259
1.00 0.16 1SG 493 ATOM 493 OD2 ASP 62 20.401 39.282 -3.927 1.00
0.16 1SG 494 ATOM 494 C ASP 62 19.437 42.801 -0.773 1.00 0.16 1SG
495 ATOM 495 O ASP 62 20.299 42.749 0.100 1.00 0.16 1SG 496 ATOM
496 N SER 63 18.904 43.974 -1.168 1.00 0.20 1SG 497 ATOM 497 CA SER
63 19.352 45.201 -0.565 1.00 0.20 1SG 498 ATOM 498 CB SER 63 18.578
46.439 -1.050 1.00 0.20 1SG 499 ATOM 499 OG SER 63 17.217 46.346
-0.655 1.00 0.20 1SG 500 ATOM 500 C SER 63 19.192 45.109 0.923 1.00
0.20 1SG 501 ATOM 501 O SER 63 18.201 44.586 1.430 1.00 0.20 1SG
502 ATOM 502 N GLY 64 20.203 45.609 1.665 1.00 0.22 1SG 503 ATOM
503 CA GLY 64 20.164 45.561 3.098 1.00 0.22 1SG 504 ATOM 504 C GLY
64 21.570 45.701 3.585 1.00 0.22 1SG 505 ATOM 505 O GLY 64 22.472
46.032 2.817 1.00 0.22 1SG 506 ATOM 506 N GLU 65 21.792 45.447
4.892 1.00 0.19 1SG 507 ATOM 507 CA GLU 65 23.115 45.557 5.436 1.00
0.19 1SG 508 ATOM 508 CB GLU 65 23.191 46.214 6.825 1.00 0.19 1SG
509 ATOM 509 CG GLU 65 22.869 47.707 6.845 1.00 0.19 1SG 510 ATOM
510 CD GLU 65 23.123 48.205 8.262 1.00 0.19 1SG 511 ATOM 511 OE1
GLU 65 22.725 47.496 9.225 1.00 0.19 1SG 512 ATOM 512 OE2 GLU 65
23.734 49.299 8.401 1.00 0.19 1SG 513 ATOM 513 C GLU 65 23.647
44.176 5.620 1.00 0.19 1SG 514 ATOM 514 O GLU 65 22.902 43.245
5.925 1.00 0.19 1SG 515 ATOM 515 N TYR 66 24.970 44.009 5.422 1.00
0.22 1SG 516 ATOM 516 CA TYR 66 25.570 42.720 5.594 1.00 0.22 1SG
517 ATOM 517 CB TYR 66 26.312 42.202 4.348 1.00 0.22 1SG 518 ATOM
518 CG TYR 66 25.308 41.992 3.266 1.00 0.22 1SG 519 ATOM 519 CD1
TYR 66 24.943 43.031 2.440 1.00 0.22 1SG 520 ATOM 520 CD2 TYR 66
24.726 40.759 3.079 1.00 0.22 1SG 521 ATOM 521 CE1 TYR 66 24.019
42.842 1.440 1.00 0.22 1SG 522 ATOM 522 CE2 TYR 66 23.800 40.563
2.081 1.00 0.22 1SG 523 ATOM 523 CZ TYR 66 23.446 41.606 1.260 1.00
0.22 1SG 524 ATOM 524 OH TYR 66 22.497 41.407 0.236 1.00 0.22 1SG
525 ATOM 525 C TYR 66 26.580 42.828 6.692 1.00 0.22 1SG 526 ATOM
526 O TYR 66 27.258 43.845 6.835 1.00 0.22 1SG 527 ATOM 527 N LYS
67 26.683 41.768 7.516 1.00 0.45 1SG 528 ATOM 528 CA LYS 67 27.618
41.753 8.602 1.00 0.45 1SG 529 ATOM 529 CB LYS 67 26.953 42.023
9.958 1.00 0.45 1SG 530 ATOM 530 CG LYS 67 26.340 43.420 10.055
1.00 0.45 1SG 531 ATOM 531 CD LYS 67 25.324 43.562 11.188 1.00 0.45
1SG 532 ATOM 532 CE LYS 67 23.974 42.913 10.871 1.00 0.45 1SG 533
ATOM 533 NZ LYS 67 23.325 43.628 9.750 1.00 0.45 1SG 534 ATOM 534 C
LYS 67 28.183 40.371 8.662 1.00 0.45 1SG 535 ATOM 535 O LYS 67
27.569 39.421 8.180 1.00 0.45 1SG 536 ATOM 536 N CYS 68 29.390
40.228 9.244 1.00 0.52 1SG 537 ATOM 537 CA CYS 68 30.003 38.935
9.333 1.00 0.52 1SG 538 ATOM 538 CB CYS 68 31.059 38.703 8.250 1.00
0.52 1SG 539 ATOM 539 SG CYS 68 32.113 37.291 8.666 1.00 0.52 1SG
540 ATOM 540 C CYS 68 30.754 38.840 10.621 1.00 0.52 1SG 541 ATOM
541 O CYS 68 31.295 39.830 11.110 1.00 0.52 1SG 542 ATOM 542 N GLN
69 30.796 37.631 11.218 1.00 0.27 1SG 543 ATOM 543 CA GLN 69 31.610
37.462 12.382 1.00 0.27 1SG 544 ATOM 544 CB GLN 69 30.855 37.549
13.718 1.00 0.27 1SG 545 ATOM 545 CG GLN 69 29.833 36.434 13.927
1.00 0.27 1SG 546 ATOM 546 CD GLN 69 29.290 36.575 15.342 1.00 0.27
1SG 547 ATOM 547 OE1 GLN 69 29.847 37.306 16.160 1.00 0.27 1SG 548
ATOM 548 NE2 GLN 69 28.177 35.853 15.642 1.00 0.27 1SG 549 ATOM 549
C GLN 69 32.221 36.103 12.322 1.00 0.27 1SG 550 ATOM 550 O GLN 69
31.741 35.214 11.620 1.00 0.27 1SG 551 ATOM 551 N HIS 70 33.333
35.928 13.056 1.00 0.11 1SG 552 ATOM 552 CA HIS 70 33.988 34.660
13.145 1.00 0.11 1SG 553 ATOM 553 ND1 HIS 70 35.166 33.594 10.252
1.00 0.11 1SG 554 ATOM 554 CG HIS 70 35.399 34.688 11.056 1.00 0.11
1SG 555 ATOM 555 CB HIS 70 35.405 34.631 12.551 1.00 0.11 1SG 556
ATOM 556 NE2 HIS 70 35.486 35.325 8.894 1.00 0.11 1SG 557 ATOM 557
CD2 HIS 70 35.593 35.736 10.211 1.00 0.11 1SG 558 ATOM 558 CE1 HIS
70 35.229 34.031 8.970 1.00 0.11 1SG 559 ATOM 559 C HIS 70 34.110
34.372 14.599 1.00 9.11 1SG 560 ATOM 560 O HIS 70 33.793 35.212
15.438 1.00 0.11 1SG 561 ATOM 561 N GLN 71 34.541 33.146 14.938
1.00 0.12 1SG 562 ATOM 562 CA GLN 71 34.685 32.822 16.322 1.00 0.12
1SG 563 ATOM 563 CB GLN 71 35.169 31.379 16.553
1.00 0.12 1SG 564 ATOM 564 CG GLN 71 34.160 30.298 16.156 1.00 0.12
1SG 565 ATOM 565 CD GLN 71 33.100 30.213 17.246 1.00 0.12 1SG 566
ATOM 566 OE1 GLN 71 33.038 31.052 18.143 1.00 0.12 1SG 567 ATOM 567
NE2 GLN 71 32.237 29.166 17.171 1.00 0.12 1SG 568 ATOM 568 C GLN 71
35.731 33.730 16.880 1.00 0.12 1SG 569 ATOM 569 O GLN 71 35.580
34.277 17.970 1.00 0.12 1SG 570 ATOM 570 N GLN 72 36.827 33.913
16.123 1.00 0.21 1SG 571 ATOM 571 CA GLN 72 37.952 34.675 16.575
1.00 0.21 1SG 572 ATOM 572 CB GLN 72 39.129 34.611 15.587 1.00 0.21
1SG 573 ATOM 573 CG GLN 72 39.531 33.182 15.217 1.00 0.21 1SG 574
ATOM 574 CD GLN 72 39.805 32.408 16.498 1.00 0.21 1SG 575 ATOM 575
OE1 GLN 72 40.001 32.986 17.566 1.00 0.21 1SG 576 ATOM 576 NE2 GLN
72 39.809 31.053 16.390 1.00 0.21 1SG 577 ATOM 577 C GLN 72 37.612
36.126 16.723 1.00 0.21 1SG 578 ATOM 578 O GLN 72 37.927 36.739
17.741 1.00 0.21 1SG 579 ATOM 579 N VAL 73 36.943 36.714 15.712
1.00 0.31 1SG 580 ATOM 580 CA VAL 73 36.757 38.137 15.714 1.00 0.31
1SG 581 ATOM 581 CB VAL 73 36.891 38.749 14.349 1.00 0.31 1SG 582
ATOM 582 CG1 VAL 73 38.329 38.520 13.852 1.00 0.31 1SG 583 ATOM 583
CG2 VAL 73 35.809 38.152 13.433 1.00 0.31 1SG 584 ATOM 584 C VAL 73
35.419 38.532 16.245 1.00 0.31 1SG 585 ATOM 585 O VAL 73 34.556
37.707 16.541 1.00 0.31 1SG 586 ATOM 586 N ASN 74 35.258 39.864
16.381 1.00 0.41 1SG 587 ATOM 587 CA ASN 74 34.078 40.535 16.838
1.00 0.41 1SG 588 ATOM 588 CB ASN 74 34.389 41.966 17.323 1.00 0.41
1SG 589 ATOM 589 CG ASN 74 33.215 42.515 18.119 1.00 0.41 1SG 590
ATOM 590 OD1 ASN 74 32.226 41.823 18.353 1.00 0.41 1SG 591 ATOM 591
ND2 ASN 74 33.322 43.804 18.540 1.00 0.41 1SG 592 ATOM 592 C ASN 74
33.177 40.636 15.647 1.00 0.41 1SG 593 ATOM 593 O ASN 74 33.389
39.959 14.644 1.00 0.41 1SG 594 ATOM 594 N GLU 75 32.113 41.457
15.746 1.00 0.48 1SG 595 ATOM 595 CA GLU 75 31.220 41.642 14.641
1.00 0.48 1SG 596 ATOM 596 CB GLU 75 29.879 42.271 15.056 1.00 0.48
1SG 597 ATOM 597 CG GLU 75 29.072 41.393 16.014 1.00 0.48 1SG 598
ATOM 598 CD GLU 75 28.504 40.229 15.218 1.00 0.48 1SG 599 ATOM 599
OE1 GLU 75 28.423 40.354 13.967 1.00 0.48 1SG 600 ATOM 600 OE2 GLU
75 28.141 39.200 15.848 1.00 0.48 1SG 601 ATOM 601 C GLU 75 31.884
42.588 13.693 1.00 0.48 1SG 602 ATOM 602 O GLU 75 32.611 43.491
14.107 1.00 0.48 1SG 603 ATOM 603 N SER 76 31.657 42.386 12.381
1.00 0.42 1SG 604 ATOM 604 CA SER 76 32.239 43.230 11.379 1.00 0.42
1SG 605 ATOM 605 CB SER 76 32.350 42.539 10.010 1.00 0.42 1SG 606
ATOM 606 OG SER 76 32.918 43.427 9.061 1.00 0.42 1SG 607 ATOM 607 C
SER 76 31.346 44.416 11.208 1.00 0.42 1SG 668 ATOM 608 O SER 76
30.182 44.388 11.604 1.00 0.42 1SG 609 ATOM 609 N GLU 77 31.884
45.509 10.627 1.00 0.31 1SG 610 ATOM 610 CA GLU 77 31.059 46.657
10.396 1.00 0.31 1SG 611 ATOM 611 CB GLU 77 31.813 47.908 9.915
1.00 0.31 1SG 612 ATOM 612 CG GLU 77 32.856 48.431 10.898 1.00 0.31
1SG 613 ATOM 613 CD GLU 77 34.144 47.681 10.608 1.00 0.31 1SG 614
ATOM 614 OE1 GLU 77 34.416 47.430 9.403 1.00 0.31 1SG 615 ATOM 615
OE2 GLU 77 34.871 47.348 11.581 1.00 0.31 1SG 616 ATOM 616 C GLU 77
30.149 46.280 9.278 1.00 0.31 1SG 617 ATOM 617 O GLU 77 30.493
45.470 8.419 1.00 0.31 1SG 618 ATOM 618 N PRO 78 28.978 46.839
9.296 1.00 0.29 1SG 619 ATOM 619 CA PRO 78 28.046 46.505 8.257 1.00
0.29 1SG 620 ATOM 620 CD PRO 78 28.309 47.037 10.573 1.00 0.29 1SG
621 ATOM 621 CB PRO 78 26.663 46.846 8.806 1.00 0.29 1SG 622 ATOM
622 CG PRO 78 26.830 46.701 10.328 1.00 0.29 1SG 623 ATOM 623 C PRO
78 28.349 47.178 6.959 1.00 0.29 1SG 624 ATOM 624 O PRO 78 28.956
48.248 6.958 1.00 0.29 1SG 625 ATOM 625 N VAL 79 27.945 46.539
5.845 1.00 0.31 1SG 626 ATOM 626 CA VAL 79 28.075 47.100 4.536 1.00
0.31 1SG 627 ATOM 627 CB VAL 79 28.861 46.242 3.590 1.00 0.31 1SG
628 ATOM 628 CG1 VAL 79 28.171 44.872 3.480 1.00 0.31 1SG 629 ATOM
629 CG2 VAL 79 28.983 46.983 2.247 1.00 0.31 1SG 630 ATOM 630 C VAL
79 26.678 47.181 4.020 1.00 0.31 1SG 631 ATOM 631 O VAL 79 25.899
46.245 4.193 1.00 0.31 1SG 632 ATOM 632 N TYR 80 26.305 48.306
3.381 1.00 0.19 1SG 633 ATOM 633 CA TYR 80 24.946 48.385 2.937 1.00
0.19 1SG 634 ATOM 634 CB TYR 80 24.256 49.729 3.235 1.00 0.19 1SG
635 ATOM 635 CG TYR 80 22.813 49.553 2.905 1.00 0.19 1SG 636 ATOM
636 CD1 TYR 80 22.346 49.756 1.626 1.00 0.19 1SG 637 ATOM 637 CD2
TYR 80 21.926 49.172 3.886 1.00 0.19 1SG 638 ATOM 638 CE1 TYR 80
21.013 49.586 1.333 1.00 0.19 1SG 639 ATOM 639 CE2 TYR 80 20.593
49.000 3.600 1.00 0.19 1SG 640 ATOM 640 CZ TYR 80 20.135 49.209
2.322 1.00 0.19 1SG 641 ATOM 641 OH TYR 80 18.767 49.033 2.023 1.00
0.19 1SG 642 ATOM 642 C TYR 80 24.940 48.188 1.459 1.00 0.19 1SG
643 ATOM 643 O TYR 80 25.745 48.771 0.734 1.00 0.19 1SG 644 ATOM
644 N LEU 81 24.021 47.332 0.979 1.00 0.08 1SG 645 ATOM 645 CA LEU
81 23.950 47.054 -0.424 1.00 0.08 1SG 646 ATOM 646 CB LEU 81 24.024
45.551 -0.740 1.00 0.08 1SG 647 ATOM 647 CG LEU 81 23.950 45.230
-2.243 1.00 0.08 1SG 648 ATOM 648 CD2 LEU 81 23.763 43.724 -2.484
1.00 0.08 1SG 649 ATOM 649 CD1 LEU 81 25.157 45.810 -2.996 1.00
0.08 1SG 650 ATOM 650 C LEU 81 22.632 47.548 -0.923 1.00 0.08 1SG
651 ATOM 651 O LEU 81 21.611 47.411 -0.251 1.00 0.08 1SG 652 ATOM
652 N GLU 82 22.633 48.166 -2.119 1.00 0.09 1SG 653 ATOM 653 CA GLU
82 21.417 48.652 -2.696 1.00 0.09 1SG 654 ATOM 654 CB GLU 82 21.424
50.176 -2.909 1.00 0.09 1SG 655 ATOM 655 CG GLU 82 21.484 50.982
-1.610 1.00 0.09 1SG 656 ATOM 656 CD GLU 82 21.724 52.442 -1.972
1.00 0.09 1SG 657 ATOM 657 OE1 GLU 82 21.178 52.895 -3.014 1.00
0.09 1SG 658 ATOM 658 OE2 GLU 82 22.467 53.122 -1.216 1.00 0.09 1SG
659 ATOM 659 C GLU 82 21.317 48.028 -4.048 1.00 0.09 1SG 660 ATOM
660 O GLU 82 22.273 48.049 -4.822 1.00 0.09 1SG 661 ATOM 661 N VAL
83 20.151 47.442 -4.369 1.00 0.09 1SG 662 ATOM 662 CA VAL 83 19.999
46.839 -5.659 1.00 0.09 1SG 663 ATOM 663 CB VAL 83 19.493 45.431
-5.602 1.00 0.09 1SG 664 ATOM 664 CG1 VAL 83 20.533 44.566 -4.871
1.00 0.09 1SG 665 ATOM 665 CG2 VAL 83 18.111 45.445 -4.931 1.00
0.09 1SG 666 ATOM 666 C VAL 83 18.974 47.642 -6.383 1.00 0.09 1SG
667 ATOM 667 O VAL 83 17.973 48.052 -5.797 1.00 0.09 1SG 668 ATOM
668 N PHE 84 19.207 47.907 -7.682 1.00 0.23 1SG 669 ATOM 669 CA PHE
84 18.257 48.698 -8.403 1.00 0.23 1SG 670 ATOM 670 CB PHE 84 18.805
50.055 -8.873 1.00 0.23 1SG 671 ATOM 671 CG PHE 84 19.450 50.743
-7.723 1.00 0.23 1SG 672 ATOM 672 CD1 PHE 84 18.715 51.444 -6.799
1.00 0.23 1SG 673 ATOM 673 CD2 PHE 84 20.812 50.670 -7.567 1.00
0.23 1SG 674 ATOM 674 CE1 PHE 84 19.328 52.069 -5.740 1.00 0.23 1SG
675 ATOM 675 CE2 PHE 84 21.428 51.294 -6.510 1.00 0.23 1SG 676 ATOM
676 CZ PHE 84 20.689 51.999 -5.594 1.00 0.23 1SG 677 ATOM 677 C PHE
84 17.966 47.967 -9.668 1.00 0.23 1SG 678 ATOM 678 O PHE 84 18.750
47.124 -10.101 1.00 0.23 1SG 679 ATOM 679 N SER 85 16.802 48.247
-10.283 1.00 0.34 1SG 680 ATOM 680 CA SER 85 16.544 47.653 -11.558
1.00 0.34 1SG 681 ATOM 681 CB SER 85 15.248 46.824 -11.611 1.00
0.34 1SG 682 ATOM 682 OG SER 85 14.121 47.637 -11.326 1.00 0.34 1SG
683 ATOM 683 C SER 85 16.439 48.779 -12.538 1.00 0.34 1SG 684 ATOM
684 O SER 85 15.403 49.431 -12.656 1.00 0.34 1SG 685 ATOM 685 N ASP
86 17.538 49.042 -13.267 1.00 0.23 1SG 686 ATOM 686 CA ASP 86
17.542 50.101 -14.232 1.00 0.23 1SG 687 ATOM 687 CB ASP 86 18.144
51.413 -13.702 1.00 0.23 1SG 688 ATOM 688 CG ASP 86 17.182 51.997
-12.678 1.00 0.23 1SG 689 ATOM 689 OD1 ASP 86 15.949 51.949 -12.931
1.00 0.23 1SG 690 ATOM 690 OD2 ASP 86 17.667 52.492 -11.625 1.00
0.23 1SG 691 ATOM 691 C ASP 86 18.413 49.652 -15.356 1.00 0.23 1SG
692 ATOM 692 O ASP 86 19.189 48.709 -15.213 1.00 0.23 1SG 693 ATOM
693 N TRP 87 18.280 50.297 -16.529 1.00 0.14 1SG 694 ATOM 694 CA
TRP 87 19.116 49.918 -17.626 1.00 0.14 1SG 695 ATOM 695 CB TRP 87
18.696 50.502 -18.982 1.00 0.14 1SG 696 ATOM 696 CG TRP 87 17.552
49.733 -19.589 1.00 0.14 1SG 697 ATOM 697 CD2 TRP 87 17.711 48.410
-20.124 1.00 0.14 1SG 698 ATOM 698 CD1 TRP 87 16.234 50.051 -19.727
1.00 0.14 1SG 699 ATOM 699 NE1 TRP 87 15.562 49.008 -20.322 1.00
0.14 1SG 700 ATOM 700 CE2 TRP 87 16.460 47.990 -20.570 1.00 0.14
1SG 701 ATOM 701 CE3 TRP 87 18.813 47.610 -20.230 1.00 0.14 1SG 702
ATOM 702 CZ2 TRP 87 16.289 46.756 -21.133 1.00 0.14 1SG 703 ATOM
703 CZ3 TRP 87 18.640 46.369 -20.801 1.00 0.14 1SG 704 ATOM 704 CH2
TRP 87 17.402 45.949 -21.244 1.00 0.14 1SG 705 ATOM 705 C TRP 87
20.535 50.295 -17.364 1.00 0.14 1SG 706 ATOM 706 O TRP 87 21.443
49.504 -17.607 1.00 0.14 1SG 707 ATOM 707 N LEU 88 20.772 51.514
-16.847 1.00 0.12 1SG 708 ATOM 708 CA LEU 88 22.128 51.938 -16.649
1.00 0.12 1SG 709 ATOM 709 CB LEU 88 22.571 52.993 -17.679 1.00
0.12 1SG 710 ATOM 710 CG LEU 88 24.024 53.484 -17.521 1.00 0.12 1SG
711 ATOM 711 CD2 LEU 88 24.277 54.759 -18.343 1.00 0.12 1SG 712
ATOM 712 CD1 LEU 88 25.038 52.377 -17.830 1.00 0.12 1SG 713 ATOM
713 C LEU 88 22.224 52.584 -15.307 1.00 0.12 1SG 714 ATOM 714 O LEU
88 21.278 53.228 -14.856 1.00 0.12 1SG 715 ATOM 715 N LEU 89 23.374
52.412 -14.622 1.00 0.11 1SG 716 ATOM 716 CA LEU 89 23.535 53.058
-13.352 1.00 0.11 1SG 717 ATOM 717 CB LEU 89 23.298 52.139 -12.138
1.00 0.11 1SG 718 ATOM 718 CG LEU 89 23.481 52.831 -10.774 1.00
0.11 1SG 719 ATOM 719 CD2 LEU 89 23.511 51.805 -9.629 1.00 0.11 1SG
720 ATOM 720 CD1 LEU 89 22.428 53.934 -10.560 1.00 0.11 1SG 721
ATOM 721 C LEU 89 24.951 53.524 -13.265 1.00 0.11 1SG 722 ATOM 722
O LEU 89 25.847 52.949 -13.882 1.00 0.11 1SG 723 ATOM 723 N LEU 90
25.182 54.611 -12.507 1.00 0.11 1SG 724 ATOM 724 CA LEU 90 26.528
55.046 -12.310 1.00 0.11 1SG 725 ATOM 725 CB LEU 90 26.688 56.576
-12.242 1.00 0.11 1SG 726 ATOM 726 CG LEU 90 28.146 57.033 -12.047
1.00 0.11 1SG 727 ATOM 727 CD2 LEU 90 28.228 58.537 -11.741 1.00
0.11 1SG 728 ATOM 728 CD1 LEU 90 29.013 56.629 -13.250 1.00 0.11
1SG 729 ATOM 729 C LEU 90 26.875 54.478 -10.975 1.00 0.11 1SG 730
ATOM 730 O LEU 90 26.167 54.707 -9.996 1.00 0.11 1SG 731 ATOM 731 N
GLN 91 27.972 53.704 -10.903 1.00 0.11 1SG 732 ATOM 732 CA GLN 91
28.255 53.028 -9.674 1.00 0.11 1SG 733 ATOM 733 CB GLN 91 28.619
51.545 -9.880 1.00 0.11 1SG 734 ATOM 734 CG GLN 91 27.482 50.714
-10.484 1.00 0.11 1SG 735 ATOM 735 CD GLN 91 27.980 49.285 -10.669
1.00 0.11 1SG 736 ATOM 736 OE1 GLN 91 29.136 49.064 -11.026 1.00
0.11 1SG 737 ATOM 737 NE2 GLN 91 27.089 48.288 -10.419 1.00 0.11
1SG 738 ATOM 738 C GLN 91 29.413 53.684 -9.004 1.00 0.11 1SG 739
ATOM 739 O GLN 91 30.329 54.186 -9.654 1.00 0.11 1SG 740 ATOM 740 N
ALA 92 29.370 53.720 -7.658 1.00 0.18 1SG 741 ATOM 741 CA ALA 92
30.446 54.291 -6.909 1.00 0.18 1SG 742 ATOM 742 CB ALA 92 30.134
55.687 -6.346 1.00 0.18 1SG 743 ATOM 743 C ALA 92 30.703 53.398
-5.743 1.00 0.18 1SG 744 ATOM 744 O ALA 92 29.797 52.745 -5.231
1.00 0.18 1SG 745 ATOM 745 N SER 93 31.975 53.316 -5.319 1.00 0.25
1SG 746 ATOM 746 CA SER 93 32.314 52.505 -4.192 1.00 0.25 1SG 747
ATOM 747 CB SER 93 33.830 52.393 -3.991 1.00 0.25 1SG 748 ATOM 748
OG SER 93 34.110 51.577 -2.865 1.00 0.25 1SG 749 ATOM 749 C SER 93
31.729 53.125 -2.961 1.00 0.25 1SG 750 ATOM 750 O SER 93 31.113
52.443 -2.144 1.00 0.25 1SG 751 ATOM 751 N ALA 94 31.898 54.454
-2.798 1.00 0.19 1SG 752 ATOM 752 CA ALA 94 31.393 55.085 -1.611
1.00 0.19 1SG 753 ATOM 753 CB ALA 94 32.469 55.303 -0.534 1.00 0.19
1SG 754 ATOM 754 C ALA 94 30.843 56.428 -1.971 1.00 0.19 1SG 755
ATOM 755 O ALA 94 31.285 57.069 -2.923 1.00 0.19 1SG 756 ATOM 756 N
GLU 95 29.814 56.855 -1.216 1.00 0.12 1SG 757 ATOM 757 CA GLU 95
29.169 58.121 -1.400 1.00 0.12 1SG 758 ATOM 758 CB GLU 95 27.888
58.222 -0.553 1.00 0.12 1SG 759 ATOM 759 CG GLU 95 26.823 57.198
-0.963 1.00 0.12 1SG 760 ATOM 760 CD GLU 95 25.743 57.151 0.108
1.00 0.12 1SG 761 ATOM 761 OE1 GLU 95 25.714 58.073 0.966 1.00 0.12
1SG 762 ATOM 762 OE2 GLU 95 24.930 56.188 0.080 1.00 0.12 1SG 763
ATOM 763 C GLU 95 30.096 59.221 -0.983 1.00 0.12 1SG 764 ATOM 764 O
GLU 95 30.230 60.228 -1.676 1.00 0.12 1SG 765 ATOM 765 N VAL 96
30.780 59.047 0.164 1.00 0.11 1SG 766 ATOM 766 CA VAL 96 31.626
60.097 0.652 1.00 0.11 1SG 767 ATOM 767 CB VAL 96 31.355 60.462
2.080 1.00 0.11 1SG 768 ATOM 768 CG1 VAL 96 32.367 61.537 2.516
1.00 0.11 1SG 769 ATOM 769 CG2 VAL 96 29.886 60.903 2.191 1.00 0.11
1SG 770 ATOM 770 C VAL 96 33.039 59.638 0.573 1.00 0.11 1SG 771
ATOM 771 O VAL 96 33.336 58.455 0.737 1.00 0.11 1SG 772 ATOM 772 N
VAL 97 33.954 60.587 0.303 1.00 0.10 1SG 773 ATOM 773 CA VAL 97
35.339 60.254 0.175 1.00 0.10 1SG 774 ATOM 774 CB VAL 97 35.826
60.312 -1.243 1.00 0.10 1SG 775 ATOM 775 CG1 VAL 97 35.078 59.249
-2.062 1.00 0.10 1SG 776 ATOM 776 CG2 VAL 97 35.642 61.745 -1.768
1.00 0.10 1SG 777 ATOM 777 C VAL 97 36.119 61.271 0.931 1.00 0.10
1SG 778 ATOM 778 O VAL 97 35.603 62.323 1.300 1.00 0.10 1SG 779
ATOM 779 N MET 98 37.402 60.962 1.185 1.00 0.12 1SG 780 ATOM 780 CA
MET 98 38.263 61.868 1.879 1.00 0.12 1SG 781 ATOM 781 CB MET 98
39.295 61.145 2.762 1.00 0.12 1SG 782 ATOM 782 CG MET 98 38.651
60.261 3.835 1.00 0.12 1SG 783 ATOM 783 SD MET 98 37.735 61.156
5.127 1.00 0.12 1SG 784 ATOM 784 CE MET 98 39.181 61.447 6.184 1.00
0.12 1SG 785 ATOM 785 C MET 98 39.008 62.583 0.802 1.00 0.12 1SG
786 ATOM 786 O MET 98 39.188 62.048 -0.290 1.00 0.12 1SG 787 ATOM
787 N GLU 99 39.440 63.830 1.057 1.00 0.10 1SG 788 ATOM 788 CA GLU
99 40.130 64.507 0.002 1.00 0.10 1SG 789 ATOM 789 CB GLU 99 40.449
65.986 0.286 1.00 0.10 1SG 790 ATOM 790 CG GLU 99 41.112 66.684
-0.906 1.00 0.10 1SG 791 ATOM 791 CD GLU 99 41.405 68.130 -0.533
1.00 0.10 1SG 792 ATOM 792 OE1 GLU 99 40.500 68.797 0.034 1.00 0.10
1SG 793 ATOM 793 OE2 GLU 99 42.546 68.586 -0.812 1.00 0.10 1SG 794
ATOM 794 C GLU 99 41.427 63.806 -0.211 1.00 0.10 1SG 795 ATOM 795 O
GLU 99 42.056 63.330 0.733 1.00 0.10 1SG 796 ATOM 796 N GLY 100
41.846 63.711 -1.486 1.00 0.20 1SG 797 ATOM 797 CA GLY 100 43.097
63.098 -1.803 1.00 0.20 1SG 798 ATOM 798 C GLY 100 42.858 61.680
-2.198 1.00 0.20 1SG 799 ATOM 799 O GLY 100 43.718 61.061 -2.822
1.00 0.20 1SG 800 ATOM 800 N GLN 101 41.686 61.111 -1.860 1.00 0.50
1SG 801 ATOM 801 CA GLN 101 41.519 59.748 -2.261 1.00 0.50 1SG 802
ATOM 802 CB GLN 101 40.589 58.891 -1.379 1.00 0.50 1SG 803 ATOM 803
CG GLN 101 39.119 59.298 -1.332 1.00 0.50 1SG 804 ATOM 804 CD GLN
101 38.416 58.229 -0.499 1.00 0.50 1SG 805 ATOM 805 OE1 GLN 101
37.204 58.040 -0.574 1.00 0.50 1SG 806 ATOM 806 NE2 GLN 101 39.213
57.489 0.318 1.00 0.50 1SG 807 ATOM 807 C GLN 101 41.046 59.724
-3.672 1.00 0.50 1SG 808 ATOM 808 O GLN 101 40.446 60.674 -4.176
1.00 0.50 1SG 809 ATOM 809 N PRO 102 41.375 58.654 -4.332 1.00 0.57
1SG 810 ATOM 810 CA PRO 102 40.964 58.525 -5.698 1.00 0.57 1SG 811
ATOM 811 CD PRO 102 42.668 58.028 -4.098 1.00 0.57 1SG 812 ATOM 812
CB PRO 102 41.873 57.469 -6.321 1.00 0.57 1SG 813 ATOM 813 CG PRO
102 43.156 57.556 -5.478 1.00 0.57 1SG 814 ATOM 814 C PRO 102
39.518 58.180 -5.764 1.00 0.57 1SG 815 ATOM 815 O PRO 102 39.021
57.507 -4.864 1.00 0.57 1SG 816 ATOM 816 N LEU 103 38.823 58.637
-6.818 1.00 0.26 1SG 817 ATOM 817 CA LEU 103 37.446 58.299 -6.967
1.00 0.26 1SG 818 ATOM 818 CB LEU 103 36.529 59.508 -7.225 1.00
0.26 1SG 819 ATOM 819 CG LEU 103 35.043 59.129 -7.383 1.00 0.26 1SG
820 ATOM 820 CD2 LEU 103 34.221 60.312 -7.920 1.00 0.26 1SG 821
ATOM 821 CD1 LEU 103 34.473 58.542 -6.082 1.00 0.26 1SG 822 ATOM
822 C LEU 103 37.366 57.422 -8.164 1.00 0.26 1SG 823 ATOM 823 O LEU
103 37.940 57.728 -9.207 1.00 0.26 1SG 824 ATOM 824 N PHE 104
36.674 56.279 -8.032 1.00 0.08 1SG 825 ATOM 825 CA PHE 104 36.542
55.422 -9.168 1.00 0.08 1SG 826 ATOM 826 CB PHE 104 37.073 53.998
-8.931 1.00 0.08 1SG 827 ATOM 827 CG PHE 104 37.001 53.256 -10.222
1.00 0.08 1SG 828 ATOM 828 CD1 PHE 104 37.981 53.414 -11.176 1.00
0.08 1SG 829 ATOM 829 CD2 PHE 104 35.961 52.393 -10.476 1.00 0.08
1SG 830 ATOM 830 CE1 PHE 104 37.919 52.727 -12.365 1.00 0.08 1SG
831 ATOM 831 CE2 PHE 104 35.892 51.703 -11.664 1.00 0.08 1SG 832
ATOM 832 CZ PHE 104 36.873 51.871 -12.611 1.00 0.08 1SG 833 ATOM
833 C PHE 104 35.081 55.331 -9.441 1.00 0.08 1SG 834 ATOM 834 O PHE
104 34.282 55.127 -8.528 1.00 0.08 1SG 835 ATOM 835 N LEU 105
34.691 55.515 -10.715 1.00 0.10 1SG 836 ATOM 836 CA LEU 105 33.306
55.440 -11.062 1.00 0.10 1SG 837 ATOM 837 CB LEU 105 32.705 56.779
-11.524 1.00 0.10 1SG 838 ATOM 838 CG LEU 105 32.678 57.865 -10.432
1.00 0.10 1SG 839 ATOM 839 CD2 LEU 105 32.015 57.352 -9.144 1.00
0.10 1SG 840 ATOM 840 CD1 LEU 105 32.045 59.163 -10.958 1.00 0.10
1SG 841 ATOM 841 C LEU 105 33.203 54.497 -12.208
1.00 0.10 1SG 842 ATOM 842 O LEU 105 34.173 54.269 -12.929 1.00
0.10 1SG 843 ATOM 843 N ARG 106 32.014 53.900 -12.389 1.00 0.15 1SG
844 ATOM 844 CA ARG 106 31.866 52.960 -13.452 1.00 0.15 1SG 845
ATOM 845 CB ARG 106 32.026 51.519 -12.938 1.00 0.15 1SG 846 ATOM
846 CG ARG 106 31.891 50.409 -13.977 1.00 0.15 1SG 847 ATOM 847 CD
ARG 106 32.273 49.049 -13.387 1.00 0.15 1SG 848 ATOM 848 NE ARG 106
32.035 48.004 -14.420 1.00 0.15 1SG 849 ATOM 849 CZ ARG 106 31.108
47.032 -14.187 1.00 0.15 1SG 850 ATOM 850 NH1 ARG 106 30.419 47.031
-13.009 1.00 0.15 1SG 851 ATOM 851 NH2 ARG 106 30.895 46.057
-15.119 1.00 0.15 1SG 852 ATOM 852 C ARG 106 30.491 53.116 -14.005
1.00 0.15 1SG 853 ATOM 853 O ARG 106 29.531 53.327 -13.265 1.00
0.15 1SG 854 ATOM 854 N CYS 107 30.363 53.038 -15.342 1.00 0.16 1SG
855 ATOM 855 CA CYS 107 29.059 53.096 -15.924 1.00 0.16 1SG 856
ATOM 856 CB CYS 107 29.005 53.868 -17.255 1.00 0.16 1SG 857 ATOM
857 SG CYS 107 29.607 55.572 -17.068 1.00 0.16 1SG 858 ATOM 858 C
CYS 107 28.730 51.668 -16.190 1.00 0.16 1SG 859 ATOM 859 O CYS 107
29.442 50.988 -16.927 1.00 0.16 1SG 860 ATOM 860 N HIS 108 27.648
51.164 -15.572 1.00 0.11 1SG 861 ATOM 861 CA HIS 108 27.365 49.768
-15.705 1.00 0.11 1SG 862 ATOM 862 ND1 HIS 108 25.867 46.991
-14.343 1.00 0.11 1SG 863 ATOM 863 CG HIS 108 27.113 47.571 -14.417
1.00 0.11 1SG 864 ATOM 864 CB HIS 108 27.349 49.051 -14.343 1.00
0.11 1SG 865 ATOM 865 NE2 HIS 108 27.329 45.329 -14.542 1.00 0.11
1SG 866 ATOM 866 CD2 HIS 108 27.995 46.542 -14.541 1.00 0.11 1SG
867 ATOM 867 CE1 HIS 108 26.055 45.649 -14.420 1.00 0.11 1SG 868
ATOM 868 C HIS 108 26.033 49.600 -16.350 1.00 0.11 1SG 869 ATOM 869
O HIS 108 25.078 50.307 -16.033 1.00 0.11 1SG 870 ATOM 870 N GLY
109 25.949 48.636 -17.287 1.00 0.09 1SG 871 ATOM 871 CA GLY 109
24.722 48.381 -17.976 1.00 0.09 1SG 872 ATOM 872 C GLY 109 24.148
47.131 -17.403 1.00 0.09 1SG 873 ATOM 873 O GLY 109 24.870 46.270
-16.904 1.00 0.09 1SG 874 ATOM 874 N TRP 110 22.812 47.003 -17.469
1.00 0.32 1SG 875 ATOM 875 CA TRP 110 22.150 45.862 -16.919 1.00
0.32 1SG 876 ATOM 876 CB TRP 110 20.623 46.057 -16.844 1.00 0.32
1SG 877 ATOM 877 CG TRP 110 19.843 44.901 -16.269 1.00 0.32 1SG 878
ATOM 878 CD2 TRP 110 18.944 44.087 -17.034 1.00 0.32 1SG 879 ATOM
879 CD1 TRP 110 19.782 44.442 -14.985 1.00 0.32 1SG 880 ATOM 880
NE1 TRP 110 18.904 43.387 -14.905 1.00 0.32 1SG 881 ATOM 881 CE2
TRP 110 18.377 43.161 -16.158 1.00 0.32 1SG 882 ATOM 882 CE3 TRP
110 18.613 44.112 -18.358 1.00 0.32 1SG 883 ATOM 883 CZ2 TRP 110
17.467 42.241 -16.595 1.00 0.32 1SG 884 ATOM 884 CZ3 TRP 110 17.696
43.185 -18.796 1.00 0.32 1SG 885 ATOM 885 CH2 TRP 110 17.134 42.268
-17.932 1.00 0.32 1SG 886 ATOM 886 C TRP 110 22.469 44.684 -17.783
1.00 0.32 1SG 887 ATOM 887 O TRP 110 22.612 44.803 -18.999 1.00
0.32 1SG 888 ATOM 888 N ARG 111 22.622 43.507 -17.146 1.00 0.53 1SG
889 ATOM 889 CA ARG 111 22.948 42.292 -17.835 1.00 0.53 1SG 890
ATOM 890 CB ARG 111 21.891 41.812 -18.846 1.00 0.53 1SG 891 ATOM
891 CG ARG 111 20.728 41.061 -18.202 1.00 0.53 1SG 892 ATOM 892 CD
ARG 111 19.970 40.150 -19.176 1.00 0.53 1SG 893 ATOM 893 NE ARG 111
19.081 40.997 -20.019 1.00 0.53 1SG 894 ATOM 894 CZ ARG 111 18.507
40.481 -21.145 1.00 0.53 1SG 895 ATOM 895 NH1 ARG 111 18.813 39.213
-21.550 1.00 0.53 1SG 896 ATOM 896 NH2 ARG 111 17.649 41.243
-21.885 1.00 0.53 1SG 897 ATOM 897 C ARG 111 24.232 42.460 -18.581
1.00 0.53 1SG 898 ATOM 898 O ARG 111 24.532 41.678 -19.482 1.00
0.53 1SG 899 ATOM 899 N ASN 112 25.038 43.468 -18.204 1.00 0.33 1SG
900 ATOM 900 CA ASN 112 26.311 43.678 -18.830 1.00 0.33 1SG 901
ATOM 901 CB ASN 112 27.335 42.576 -18.504 1.00 0.33 1SG 902 ATOM
902 CG ASN 112 27.731 42.721 -17.046 1.00 0.33 1SG 903 ATOM 903 OD1
ASN 112 28.052 43.819 -16.594 1.00 0.33 1SG 904 ATOM 904 ND2 ASN
112 27.702 41.592 -16.288 1.00 0.33 1SG 905 ATOM 905 C ASN 112
26.153 43.727 -20.315 1.00 0.33 1SG 906 ATOM 906 O ASN 112 26.933
43.116 -21.046 1.00 0.33 1SG 907 ATOM 907 N TRP 113 25.146 44.464
-20.817 1.00 0.13 1SG 908 ATOM 908 CA TRP 113 25.015 44.533 -22.240
1.00 0.13 1SG 909 ATOM 909 CB TRP 113 23.669 45.100 -22.722 1.00
0.13 1SG 910 ATOM 910 CG TRP 113 22.493 44.191 -22.444 1.00 0.13
1SG 911 ATOM 911 CD2 TRP 113 22.228 42.976 -23.165 1.00 0.13 1SG
912 ATOM 912 CD1 TRP 113 21.509 44.306 -21.504 1.00 0.13 1SG 913
ATOM 913 NE1 TRP 113 20.640 43.244 -21.602 1.00 0.13 1SG 914 ATOM
914 CE2 TRP 113 21.075 42.416 -22.619 1.00 0.13 1SG 915 ATOM 915
CE3 TRP 113 22.895 42.373 -24.195 1.00 0.13 1SG 916 ATOM 916 CZ2
TRP 113 20.571 41.241 -23.102 1.00 0.13 1SG 917 ATOM 917 CZ3 TRP
113 22.379 41.191 -24.679 1.00 0.13 1SG 918 ATOM 918 CH2 TRP 113
21.238 40.635 -24.142 1.00 0.13 1SG 919 ATOM 919 C TRP 113 26.119
45.405 -22.742 1.00 0.13 1SG 920 ATOM 920 O TRP 113 26.654 46.236
-22.011 1.00 0.13 1SG 921 ATOM 921 N ASP 114 26.496 45.227 -24.022
1.00 0.12 1SG 922 ATOM 922 CA ASP 114 27.588 45.975 -24.571 1.00
0.12 1SG 923 ATOM 923 CB ASP 114 27.841 45.683 -26.059 1.00 0.12
1SG 924 ATOM 924 CG ASP 114 28.304 44.241 -26.189 1.00 0.12 1SG 925
ATOM 925 OD1 ASP 114 29.314 43.875 -25.531 1.00 0.12 1SG 926 ATOM
926 OD2 ASP 114 27.652 43.486 -26.958 1.00 0.12 1SG 927 ATOM 927 C
ASP 114 27.248 47.423 -24.474 1.00 0.12 1SG 928 ATOM 928 O ASP 114
26.138 47.838 -24.803 1.00 0.12 1SG 929 ATOM 929 N VAL 115 28.212
48.232 -23.999 1.00 0.21 1SG 930 ATOM 930 CA VAL 115 27.972 49.637
-23.884 1.00 0.21 1SG 931 ATOM 931 CB VAL 115 27.896 50.121 -22.466
1.00 0.21 1SG 932 ATOM 932 CG1 VAL 115 27.643 51.639 -22.481 1.00
0.21 1SG 933 ATOM 933 CG2 VAL 115 26.813 49.317 -21.728 1.00 0.21
1SG 934 ATOM 934 C VAL 115 29.128 50.336 -24.516 1.00 0.21 1SG 935
ATOM 935 O VAL 115 30.265 49.873 -24.449 1.00 0.21 1SG 936 ATOM 936
N TYR 116 28.848 51.473 -25.172 1.00 0.44 1SG 937 ATOM 937 CA TYR
116 29.880 52.234 -25.804 1.00 0.44 1SG 938 ATOM 938 CB TYR 116
30.062 51.874 -27.283 1.00 0.44 1SG 939 ATOM 939 CG TYR 116 28.712
52.007 -27.883 1.00 0.44 1SG 940 ATOM 940 CD1 TYR 116 28.279 53.200
-28.399 1.00 0.44 1SG 941 ATOM 941 CD2 TYR 116 27.864 50.929
-27.902 1.00 0.44 1SG 942 ATOM 942 CE1 TYR 116 27.023 53.311
-28.945 1.00 0.44 1SG 943 ATOM 943 CE2 TYR 116 26.607 51.031
-28.445 1.00 0.44 1SG 944 ATOM 944 CZ TYR 116 26.183 52.225 -28.971
1.00 0.44 1SG 945 ATOM 945 OH TYR 116 24.892 52.332 -29.530 1.00
0.44 1SG 946 ATOM 946 C TYR 116 29.464 53.663 -25.712 1.00 0.44 1SG
947 ATOM 947 O TYR 116 28.359 53.962 -25.263 1.00 0.44 1SG 948 ATOM
948 N LYS 117 30.353 54.580 -26.142 1.00 0.45 1SG 949 ATOM 949 CA
LYS 117 30.080 55.988 -26.073 1.00 0.45 1SG 950 ATOM 950 CB LYS 117
29.019 56.496 -27.064 1.00 0.45 1SG 951 ATOM 951 CG LYS 117 29.519
56.616 -28.501 1.00 0.45 1SG 952 ATOM 952 CD LYS 117 28.443 57.089
-29.479 1.00 0.45 1SG 953 ATOM 953 CE LYS 117 28.988 57.432 -30.865
1.00 0.45 1SG 954 ATOM 954 NZ LYS 117 29.035 56.215 -31.705 1.00
0.45 1SG 955 ATOM 955 C LYS 117 29.606 56.330 -24.702 1.00 0.45 1SG
956 ATOM 956 O LYS 117 28.453 56.713 -24.513 1.00 0.45 1SG 957 ATOM
957 N VAL 118 30.497 56.195 -23.704 1.00 0.21 1SG 958 ATOM 958 CA
VAL 118 30.122 56.475 -22.352 1.00 0.21 1SG 959 ATOM 959 CB VAL 118
30.761 55.541 -21.370 1.00 0.21 1SG 960 ATOM 960 CG1 VAL 118 30.419
56.016 -19.953 1.00 0.21 1SG 961 ATOM 961 CG2 VAL 118 30.294 54.109
-21.678 1.00 0.21 1SG 962 ATOM 962 C VAL 118 30.579 57.856 -22.012
1.00 0.21 1SG 963 ATOM 963 O VAL 118 31.688 58.262 -22.354 1.00
0.21 1SG 964 ATOM 964 N ILE 119 29.704 58.631 -21.340 1.00 0.09 1SG
965 ATOM 965 CA ILE 119 30.083 59.955 -20.951 1.00 0.09 1SG 966
ATOM 966 CB ILE 119 29.298 61.032 -21.637 1.00 0.09 1SG 967 ATOM
967 CG2 ILE 119 29.724 62.381 -21.035 1.00 0.09 1SG 968 ATOM 968
CG1 ILE 119 29.490 60.945 -23.159 1.00 0.09 1SG 969 ATOM 969 CD1
ILE 119 28.509 61.812 -23.947 1.00 0.09 1SG 970 ATOM 970 C ILE 119
29.821 60.088 -19.488 1.00 0.09 1SG 971 ATOM 971 O ILE 119 28.827
59.579 -18.972 1.00 0.09 1SG 972 ATOM 972 N TYR 120 30.737 60.771
-18.778 1.00 0.09 1SG 973 ATOM 973 CA TYR 120 30.560 61.006 -17.378
1.00 0.09 1SG 974 ATOM 974 CB TYR 120 31.820 60.775 -16.525 1.00
0.09 1SG 975 ATOM 975 CG TYR 120 31.970 59.317 -16.261 1.00 0.09
1SG 976 ATOM 976 CD1 TYR 120 32.530 58.457 -17.178 1.00 0.09 1SG
977 ATOM 977 CD2 TYR 120 31.540 58.817 -15.054 1.00 0.09 1SG 978
ATOM 978 CE1 TYR 120 32.652 57.117 -16.885 1.00 0.09 1SG 979 ATOM
979 CE2 TYR 120 31.659 57.483 -14.755 1.00 0.09 1SG 980 ATOM 980 CZ
TYR 120 32.217 56.631 -15.673 1.00 0.09 1SG 981 ATOM 981 OH TYR 120
32.335 55.263 -15.355 1.00 0.09 1SG 982 ATOM 982 C TYR 120 30.176
62.434 -17.220 1.00 0.09 1SG 983 ATOM 983 O TYR 120 30.750 63.318
-17.855 1.00 0.09 1SG 984 ATOM 984 N TYR 121 29.163 62.691 -16.372
1.00 0.18 1SG 985 ATOM 985 CA TYR 121 28.723 64.038 -16.193 1.00
0.18 1SG 986 ATOM 986 CB TYR 121 27.258 64.245 -16.599 1.00 0.18
1SG 987 ATOM 987 CG TYR 121 27.150 63.949 -18.056 1.00 0.18 1SG 988
ATOM 988 CD1 TYR 121 27.377 64.931 -18.993 1.00 0.18 1SG 989 ATOM
989 CD2 TYR 121 26.824 62.683 -18.486 1.00 0.18 1SG 990 ATOM 990
CE1 TYR 121 27.275 64.654 -20.337 1.00 0.18 1SG 991 ATOM 991 CE2
TYR 121 26.720 62.402 -19.827 1.00 0.18 1SG 992 ATOM 992 CZ TYR 121
26.942 63.389 -20.756 1.00 0.18 1SG 993 ATOM 993 OH TYR 121 26.834
63.101 -22.133 1.00 0.18 1SG 994 ATOM 994 C TYR 121 28.829 64.371
-14.740 1.00 0.18 1SG 995 ATOM 995 O TYR 121 28.541 63.547 -13.874
1.00 0.18 1SG 996 ATOM 996 N LYS 122 29.284 65.605 -14.456 1.00
0.28 1SG 997 ATOM 997 CA LYS 122 29.428 66.129 -13.134 1.00 0.28
1SG 998 ATOM 998 CB LYS 122 30.880 66.537 -12.818 1.00 0.28 1SG 999
ATOM 999 CG LYS 122 31.137 66.957 -11.369 1.00 0.28 1SG 1000 ATOM
1000 CD LYS 122 32.608 67.287 -11.095 1.00 0.28 1SG 1001 ATOM 1001
CE LYS 122 33.591 66.393 -11.855 1.00 0.28 1SG 1002 ATOM 1002 NZ
LYS 122 34.985 66.786 -11.541 1.00 0.28 1SG 1003 ATOM 1003 C LYS
122 28.641 67.394 -13.143 1.00 0.28 1SG 1004 ATOM 1004 O LYS 122
29.023 68.358 -13.804 1.00 0.28 1SG 1005 ATOM 1005 N ASP 123 27.517
67.417 -12.408 1.00 0.20 1SG 1006 ATOM 1006 CA ASP 123 26.698
68.590 -12.349 1.00 0.20 1SG 1007 ATOM 1007 CB ASP 123 27.342
69.736 -11.555 1.00 0.20 1SG 1008 ATOM 1008 CG ASP 123 27.300
69.305 -10.096 1.00 0.20 1SG 1009 ATOM 1009 OD1 ASP 123 26.407
68.486 -9.750 1.00 0.20 1SG 1010 ATOM 1010 OD2 ASP 123 28.159
69.781 -9.310 1.00 0.20 1SG 1011 ATOM 1011 C ASP 123 26.373 69.035
-13.739 1.00 0.20 1SG 1012 ATOM 1012 O ASP 123 26.275 70.230
-14.018 1.00 0.20 1SG 1013 ATOM 1013 N GLY 124 26.196 68.062
-14.652 1.00 0.17 1SG 1014 ATOM 1014 CA GLY 124 25.784 68.369
-15.990 1.00 0.17 1SG 1015 ATOM 1015 C GLY 124 26.969 68.690
-16.840 1.00 0.17 1SG 1016 ATOM 1016 O GLY 124 26.818 69.053
-18.006 1.00 0.17 1SG 1017 ATOM 1017 N GLU 125 28.189 68.566
-16.293 1.00 0.24 1SG 1018 ATOM 1018 CA GLU 125 29.322 68.878
-17.110 1.00 0.24 1SG 1019 ATOM 1019 CB GLU 125 30.365 69.739
-16.386 1.00 0.24 1SG 1020 ATOM 1020 CG GLU 125 31.381 70.369
-17.331 1.00 0.24 1SG 1021 ATOM 1021 CD GLU 125 32.334 71.210
-16.497 1.00 0.24 1SG 1022 ATOM 1022 OE1 GLU 125 32.596 70.818
-15.328 1.00 0.24 1SG 1023 ATOM 1023 OE2 GLU 125 32.807 72.256
-17.015 1.00 0.24 1SG 1024 ATOM 1024 C GLU 125 29.961 67.582
-17.482 1.00 0.24 1SG 1025 ATOM 1025 O GLU 125 30.165 66.716
-16.637 1.00 0.24 1SG 1026 ATOM 1026 N ALA 126 30.306 67.396
-18.766 1.00 0.26 1SG 1027 ATOM 1027 CA ALA 126 30.860 66.125
-19.130 1.00 0.26 1SG 1028 ATOM 1028 CB ALA 126 30.790 65.834
-20.639 1.00 0.26 1SG 1029 ATOM 1029 C ALA 126 32.302 66.112
-18.741 1.00 0.26 1SG 1030 ATOM 1030 O ALA 126 33.114 66.845
-19.302 1.00 0.26 1SG 1031 ATOM 1031 N LEU 127 32.645 65.289
-17.731 1.00 0.39 1SG 1032 ATOM 1032 CA LEU 127 34.008 65.183
-17.302 1.00 0.39 1SG 1033 ATOM 1033 CB LEU 127 34.179 64.277
-16.074 1.00 0.39 1SG 1034 ATOM 1034 CG LEU 127 33.482 64.807
-14.812 1.00 0.39 1SG 1035 ATOM 1035 CD2 LEU 127 33.881 63.986
-13.576 1.00 0.39 1SG 1036 ATOM 1036 CD1 LEU 127 31.960 64.884
-15.010 1.00 0.39 1SG 1037 ATOM 1037 C LEU 127 34.796 64.549
-18.400 1.00 0.39 1SG 1038 ATOM 1038 O LEU 127 35.840 65.061
-18.800 1.00 0.39 1SG 1039 ATOM 1039 N LYS 128 34.304 63.411
-18.933 1.00 0.43 1SG 1040 ATOM 1040 CA LYS 128 35.062 62.772
-19.966 1.00 0.43 1SG 1041 ATOM 1041 CB LYS 128 36.120 61.788
-19.443 1.00 0.43 1SG 1042 ATOM 1042 CG LYS 128 35.512 60.519
-18.844 1.00 0.43 1SG 1043 ATOM 1043 CD LYS 128 36.528 59.394
-18.642 1.00 0.43 1SG 1044 ATOM 1044 CE LYS 128 35.890 58.054
-18.279 1.00 0.43 1SG 1045 ATOM 1045 NZ LYS 128 35.161 57.519
-19.451 1.00 0.43 1SG 1046 ATOM 1046 C LYS 128 34.135 61.974
-20.820 1.00 0.43 1SG 1047 ATOM 1047 O LYS 128 33.048 61.582
-20.398 1.00 0.43 1SG 1048 ATOM 1048 N TYR 129 34.557 61.737
-22.075 1.00 0.26 1SG 1049 ATOM 1049 CA TYR 129 33.811 60.931
-22.993 1.00 0.26 1SG 1050 ATOM 1050 CB TYR 129 33.135 61.748
-24.108 1.00 0.26 1SG 1051 ATOM 1051 CG TYR 129 32.753 60.810
-25.201 1.00 0.26 1SG 1052 ATOM 1052 CD1 TYR 129 31.645 59.997
-25.109 1.00 0.26 1SG 1053 ATOM 1053 CD2 TYR 129 33.524 60.758
-26.339 1.00 0.26 1SG 1054 ATOM 1054 CE1 TYR 129 31.320 59.142
-26.139 1.00 0.26 1SG 1055 ATOM 1055 CE2 TYR 129 33.205 59.908
-27.369 1.00 0.26 1SG 1056 ATOM 1056 CZ TYR 129 32.101 59.099
-27.271 1.00 0.26 1SG 1057 ATOM 1057 OH TYR 129 31.779 58.229
-28.332 1.00 0.26 1SG 1058 ATOM 1058 C TYR 129 34.778 59.999
-23.647 1.00 0.26 1SG 1059 ATOM 1059 O TYR 129 35.824 60.422
-24.135 1.00 0.26 1SG 1060 ATOM 1060 N TRP 130 34.462 58.689
-23.653 1.00 0.16 1SG 1061 ATOM 1061 CA TRP 130 35.333 57.766
-24.319 1.00 0.16 1SG 1062 ATOM 1062 CB TRP 130 36.317 57.060
-23.376 1.00 0.16 1SG 1063 ATOM 1063 CG TRP 130 37.415 56.304
-24.085 1.00 0.16 1SG 1064 ATOM 1064 CD2 TRP 130 38.743 56.820
-24.263 1.00 0.16 1SG 1065 ATOM 1065 CD1 TRP 130 37.411 55.054
-24.630 1.00 0.16 1SG 1066 ATOM 1066 NE1 TRP 130 38.651 54.765
-25.146 1.00 0.16 1SG 1067 ATOM 1067 CE2 TRP 130 39.481 55.840
-24.923 1.00 0.16 1SG 1068 ATOM 1068 CE3 TRP 130 39.304 58.011
-23.900 1.00 0.16 1SG 1069 ATOM 1069 CZ2 TRP 130 40.797 56.035
-25.232 1.00 0.16 1SG 1070 ATOM 1070 CZ3 TRP 130 40.631 58.206
-24.218 1.00 0.16 1SG 1071 ATOM 1071 CH2 TRP 130 41.364 57.237
-24.872 1.00 0.16 1SG 1072 ATOM 1072 C TRP 130 34.445 56.710
-24.894 1.00 0.16 1SG 1073 ATOM 1073 O TRP 130 33.462 56.312
-24.270 1.00 0.16 1SG 1074 ATOM 1074 N TYR 131 34.742 56.241
-26.120 1.00 0.17 1SG 1075 ATOM 1075 CA TYR 131 33.876 55.242
-26.671 1.00 0.17 1SG 1076 ATOM 1076 CB TYR 131 34.256 54.830
-28.102 1.00 0.17 1SG 1077 ATOM 1077 CG TYR 131 33.897 55.923
-29.045 1.00 0.17 1SG 1078 ATOM 1078 CD1 TYR 131 34.677 57.051
-29.158 1.00 0.17 1SG 1079 ATOM 1079 CD2 TYR 131 32.777 55.801
-29.833 1.00 0.17 1SG 1080 ATOM 1080 CE1 TYR 131 34.335 58.049
-30.040 1.00 0.17 1SG 1081 ATOM 1081 CE2 TYR 131 32.430 56.794
-30.716 1.00 0.17 1SG 1082 ATOM 1082 CZ TYR 131 33.211 57.920
-30.821 1.00 0.17 1SG 1083 ATOM 1083 OH TYR 131 32.855 58.940
-31.729 1.00 0.17 1SG 1084 ATOM 1084 C TYR 131 33.952 53.988
-25.858 1.00 0.17 1SG 1085 ATOM 1085 O TYR 131 32.949 53.520
-25.323 1.00 0.17 1SG 1086 ATOM 1086 N GLU 132 35.164 53.409
-25.753 1.00 0.19 1SG 1087 ATOM 1087 CA GLU 132 35.336 52.145
-25.095 1.00 0.19 1SG 1088 ATOM 1088 CB GLU 132 36.595 51.383
-25.550 1.00 0.19 1SG 1089 ATOM 1089 CG GLU 132 37.918 52.085
-25.259 1.00 0.19 1SG 1090 ATOM 1090 CD GLU 132 39.023 51.244
-25.885 1.00 0.19 1SG 1091 ATOM 1091 OE1 GLU 132 38.999 49.998
-25.702 1.00 0.19 1SG 1092 ATOM 1092 OE2 GLU 132 39.905 51.838
-26.561 1.00 0.19 1SG 1093 ATOM 1093 C GLU 132 35.334 52.226
-23.595 1.00 0.19 1SG 1094 ATOM 1094 O GLU 132 34.804 51.333
-22.938 1.00 0.19 1SG 1095 ATOM 1095 N ASN 133 35.901 53.300
-23.008 1.00 0.18 1SG 1096 ATOM 1096 CA ASN 133 36.132 53.303
-21.586 1.00 0.18 1SG 1097 ATOM 1097 CB ASN 133 37.146 54.366
-21.119 1.00 0.18 1SG 1098 ATOM 1098 CG ASN 133 37.569 54.017
-19.697 1.00 0.18 1SG 1099 ATOM 1099 OD1 ASN 133 36.964 53.162
-19.050 1.00 0.18 1SG 1100 ATOM 1100 ND2 ASN 133 38.631 54.700
-19.191 1.00 0.18 1SG 1101 ATOM 1101 C ASN 133 34.876 53.504
-20.800 1.00 0.18 1SG 1102 ATOM 1102 O ASN 133 34.256 54.566
-20.828 1.00 0.18 1SG 1103 ATOM 1103 N HIS 134 34.477 52.431
-20.089 1.00 0.16 1SG 1104 ATOM 1104 CA HIS 134 33.342 52.361
-19.214 1.00 0.16 1SG 1105 ATOM 1105 ND1 HIS 134 31.445 50.137
-20.751 1.00 0.16 1SG 1106 ATOM 1106 CG HIS 134 32.655 50.103
-20.093 1.00 0.16 1SG 1107 ATOM 1107 CB HIS 134 32.970 50.911
-18.870 1.00 0.16 1SG 1108 ATOM 1108 NE2 HIS 134 32.738 48.717
-21.871 1.00 0.16 1SG 1109 ATOM 1109 CD2 HIS 134 33.432 49.231
-20.790 1.00 0.16 1SG 1110 ATOM 1110 CE1 HIS 134 31.550 49.291
-21.805 1.00 0.16 1SG 1111 ATOM 1111 C HIS 134 33.620 53.068
-17.920 1.00 0.16 1SG 1112 ATOM 1112 O HIS 134 32.711 53.632
-17.314 1.00 0.16 1SG 1113 ATOM 1113 N ASN 135 34.887 53.046
-17.453 1.00 0.14 1SG 1114 ATOM 1114 CA ASN 135 35.191 53.542
-16.136 1.00 0.14 1SG 1115 ATOM 1115 CB ASN 135 36.182 52.646
-15.379 1.00 0.14 1SG 1116 ATOM 1116 CG ASN 135 35.543 51.277
-15.216 1.00 0.14 1SG 1117 ATOM 1117 OD1 ASN 135 34.446 51.144
-14.676 1.00 0.14 1SG 1118 ATOM 1118 ND2 ASN 135 36.246 50.224
-15.714 1.00 0.14 1SG 1119 ATOM 1119 C ASN 135 35.824 54.896
-16.197 1.00 0.14 1SG 1120 ATOM 1120 O ASN 135 36.357 55.313
-17.223 1.00 0.14 1SG 1121 ATOM 1121 N ILE 136 35.735 55.630
-15.065 1.00 0.19 1SG 1122 ATOM 1122 CA ILE 136 36.343 56.921
-14.918 1.00 0.19 1SG 1123 ATOM 1123 CB ILE 136 35.366 58.059
-14.963 1.00 0.19 1SG 1124 ATOM 1124 CG2 ILE 136 34.435 57.932
-13.746 1.00 0.19 1SG 1125 ATOM 1125 CG1 ILE 136 36.110 59.402
-15.040 1.00 0.19 1SG 1126 ATOM 1126 CD1 ILE 136 35.202 60.579
-15.391 1.00 0.19 1SG 1127 ATOM 1127 C ILE 136 36.965 56.952
-13.559 1.00 0.19 1SG 1128 ATOM 1128 O ILE 136 36.449 56.350
-12.619 1.00 0.19 1SG 1129 ATOM 1129 N SER 137 38.112 57.642
-13.419 1.00 0.24 1SG 1130 ATOM 1130 CA SER 137 38.739 57.700
-12.133 1.00 0.24 1SG 1131 ATOM 1131 CB SER 137 39.970 56.783
-12.034 1.00 0.24 1SG 1132 ATOM 1132 OG SER 137 40.555 56.873
-10.745 1.00 0.24 1SG 1133 ATOM 1133 C SER 137 39.198 59.104
-11.907 1.00 0.24 1SG 1134 ATOM 1134 O SER 137 39.686 59.763
-12.823 1.00 0.24 1SG 1135 ATOM 1135 N ILE 138 39.035 59.607
-10.670 1.00 0.31 1SG 1136 ATOM 1136 CA ILE 138 39.486 60.933
-10.378 1.00 0.31 1SG 1137 ATOM 1137 CB ILE 138 38.419 61.805
-9.789 1.00 0.31 1SG 1138 ATOM 1138 CG2 ILE 138 39.058 63.162
-9.443 1.00 0.31 1SG 1139 ATOM 1139 CG1 ILE 138 37.227 61.911
-10.757 1.00 0.31 1SG 1140 ATOM 1140 CD1 ILE 138 35.963 62.479
-10.116 1.00 0.31 1SG 1141 ATOM 1141 C ILE 138 40.547 60.785 -9.343
1.00 0.31 1SG 1142 ATOM 1142 O ILE 138 40.328 60.190 -8.290 1.00
0.31 1SG 1143 ATOM 1143 N THR 139 41.743 61.328 -9.610 1.00 0.40
1SG 1144 ATOM 1144 CA THR 139 42.788 61.172 -8.648 1.00 0.40 1SG
1145 ATOM 1145 CB THR 139 44.128 60.908 -9.262 1.00 0.40 1SG 1146
ATOM 1146 OG1 THR 139 44.467 61.963 -10.149 1.00 0.40 1SG 1147 ATOM
1147 CG2 THR 139 44.075 59.569 -10.013 1.00 0.40 1SG 1148 ATOM 1148
C THR 139 42.873 62.438 -7.870 1.00 0.40 1SG 1149 ATOM 1149 O THR
139 42.513 63.503 -8.369 1.00 0.40 1SG 1150 ATOM 1150 N ASN 140
43.351 62.333 -6.613 1.00 0.29 1SG 1151 ATOM 1151 CA ASN 140 43.471
63.472 -5.750 1.00 0.29 1SG 1152 ATOM 1152 CB ASN 140 44.596 64.437
-6.160 1.00 0.29 1SG 1153 ATOM 1153 CG ASN 140 45.928 63.762 -5.868
1.00 0.29 1SG 1154 ATOM 1154 OD1 ASN 140 46.306 62.785 -6.513 1.00
0.29 1SG 1155 ATOM 1155 ND2 ASN 140 46.667 64.304 -4.864 1.00 0.29
1SG 1156 ATOM 1156 C ASN 140 42.181 64.224 -5.754 1.00 0.29 1SG
1157 ATOM 1157 O ASN 140 42.115 65.358 -6.226 1.00 0.29 1SG 1158
ATOM 1158 N ALA 141 41.113 63.595 -5.227 1.00 0.26 1SG 1159 ATOM
1159 CA ALA 141 39.821 64.215 -5.216 1.00 0.26 1SG 1160 ATOM 1160
CB ALA 141 38.719 63.333 -4.603 1.00 0.26 1SG 1161 ATOM 1161 C ALA
141 39.898 65.471 -4.413 1.00 0.26 1SG 1162 ATOM 1162 O ALA 141
40.719 65.603 -3.507 1.00 0.26 1SG 1163 ATOM 1163 N THR 142 39.031
66.442 -4.762 1.00 0.35 1SG 1164 ATOM 1164 CA THR 142 38.998 67.708
-4.097 1.00 0.35 1SG 1165 ATOM 1165 CB THR 142 39.528 68.833 -4.935
1.00 0.35 1SG 1166 ATOM 1166 OG1 THR 142 39.621 70.022 -4.165 1.00
0.35 1SG 1167 ATOM 1167 CG2 THR 142 38.582 69.043 -6.130 1.00 0.35
1SG 1168 ATOM 1168 C THR 142 37.569 68.019 -3.789 1.00 0.35 1SG
1169 ATOM 1169 O THR 142 36.665 67.266 -4.145 1.00 0.35 1SG 1170
ATOM 1170 N VAL 143 37.343 69.150 -3.095 1.00 0.29 1SG 1171 ATOM
1171 CA VAL 143 36.032 69.574 -2.700 1.00 0.29 1SG 1172 ATOM 1172
CB VAL 143 36.059 70.811 -1.856 1.00 0.29 1SG 1173 ATOM 1173 CG1
VAL 143 34.611 71.189 -1.502 1.00 0.29 1SG 1174 ATOM 1174 CG2 VAL
143 36.953 70.542 -0.631 1.00 0.29 1SG 1175 ATOM 1175 C VAL 143
35.226 69.861 -3.926 1.00 0.29 1SG 1176 ATOM 1176 O VAL 143 34.025
69.598 -3.970 1.00 0.29 1SG 1177 ATOM 1177 N GLU 144 35.880 70.403
-4.967 1.00 0.25 1SG 1178 ATOM 1178 CA GLU 144 35.205 70.752 -6.183
1.00 0.25 1SG 1179 ATOM 1179 CB GLU 144 36.143 71.376 -7.228 1.00
0.25 1SG 1180 ATOM 1180 CG GLU 144 36.668 72.746 -6.801 1.00 0.25
1SG 1181 ATOM 1181 CD GLU 144 37.666 72.520 -5.676 1.00 0.25 1SG
1182 ATOM 1182 OE1 GLU 144 38.780 72.013 -5.971 1.00 0.25 1SG 1183
ATOM 1183 OE2 GLU 144 37.326 72.845 -4.507 1.00 0.25 1SG 1184 ATOM
1184 C GLU 144 34.635 69.501 -6.767 1.00 0.25 1SG 1185 ATOM 1185 O
GLU 144 33.591 69.521 -7.417 1.00 0.25 1SG 1186 ATOM 1186 N ASP 145
35.312 68.367 -6.525 1.00 0.22 1SG 1187 ATOM 1187 CA ASP 145 34.927
67.107 -7.086 1.00 0.22 1SG 1188 ATOM 1188 CB ASP 145 35.835 65.959
-6.608 1.00 0.22 1SG 1189 ATOM 1189 CG ASP 145 35.542 64.709 -7.427
1.00 0.22 1SG 1190 ATOM 1190 OD1 ASP 145 34.357 64.287 -7.484 1.00
0.22 1SG 1191 ATOM 1191 OD2 ASP 145 36.511 64.160 -8.016 1.00 0.22
1SG 1192 ATOM 1192 C ASP 145 33.523 66.785 -6.680 1.00 0.22 1SG
1193 ATOM 1193 O ASP 145 32.759 66.255 -7.486 1.00 0.22 1SG 1194
ATOM 1194 N SER 146 33.134 67.103 -5.430 1.00 0.20 1SG 1195 ATOM
1195 CA SER 146 31.813 66.766 -4.974 1.00 0.20 1SG 1196 ATOM 1196
CB SER 146 31.492 67.291 -3.563 1.00 0.20 1SG 1197 ATOM 1197 OG SER
146 31.476 68.711 -3.564 1.00 0.20 1SG 1198 ATOM 1198 C SER 146
30.806 67.344 -5.914 1.00 0.20 1SG 1199 ATOM 1199 O SER 146 31.006
68.414 -6.488 1.00 0.20 1SG 1200 ATOM 1200 N GLY 147 29.691 66.614
-6.114 1.00 0.21 1SG 1201 ATOM 1201 CA GLY 147 28.676 67.077 -7.012
1.00 0.21 1SG 1202 ATOM 1202 C GLY 147 27.818 65.904 -7.348 1.00
0.21 1SG 1203 ATOM 1203 O GLY 147 27.869 64.869 -6.686 1.00 0.21
1SG 1204 ATOM 1204 N THR 148 26.991 66.048 -8.399 1.00 0.17 1SG
1205 ATOM 1205 CA THR 148 26.137 64.966 -8.774 1.00 0.17 1SG 1206
ATOM 1206 CB THR 148 24.735 65.398 -9.070 1.00 0.17 1SG 1207 ATOM
1207 OG1 THR 148 24.174 66.037 -7.933 1.00 0.17 1SG 1208 ATOM 1208
CG2 THR 148 23.912 64.152 -9.424 1.00 0.17 1SG 1209 ATOM 1209 C THR
148 26.701 64.381 -10.022 1.00 0.17 1SG 1210 ATOM 1210 O THR 148
27.063 65.103 -10.949 1.00 0.17 1SG 1211 ATOM 1211 N TYR 149 26.809
63.040 -10.068 1.00 0.12 1SG 1212 ATOM 1212 CA TYR 149 27.360
62.412 -11.231 1.00 0.12 1SG 1213 ATOM 1213 CB TYR 149 28.585
61.526 -10.948 1.00 0.12 1SG 1214 ATOM 1214 CG TYR 149 29.753
62.381 -10.600 1.00 0.12 1SG 1215 ATOM 1215 CD1 TYR 149 29.899
62.900 -9.335 1.00 0.12 1SG 1216 ATOM 1216 CD2 TYR 149 30.712
62.647 -11.548 1.00 0.12 1SG 1217 ATOM 1217 CE1 TYR 149 30.988
63.680 -9.026 1.00 0.12 1SG 1218 ATOM 1218 CE2 TYR 149 31.803
63.425 -11.245 1.00 0.12 1SG 1219 ATOM 1219 CZ TYR 149 31.940
63.945 -9.981 1.00 0.12 1SG 1220 ATOM 1220 OH TYR 149 33.057 64.744
-9.663 1.00 0.12 1SG 1221 ATOM 1221 C TYR 149 26.341 61.495 -11.819
1.00 0.12 1SG 1222 ATOM 1222 O TYR 149 25.587 60.836 -11.105 1.00
0.12 1SG 1223 ATOM 1223 N TYR 150 26.286 61.458 -13.164 1.00 0.12
1SG 1224 ATOM 1224 CA TYR 150 25.436 60.528 -13.842 1.00 0.12 1SG
1225 ATOM 1225 CB TYR 150 24.026 61.056 -14.177 1.00 0.12 1SG 1226
ATOM 1226 CG TYR 150 24.091 62.236 -15.083 1.00 0.12 1SG 1227 ATOM
1227 CD1 TYR 150 24.135 62.078 -16.450 1.00 0.12 1SG 1228 ATOM 1228
CD2 TYR 150 24.090 63.507 -14.559 1.00 0.12 1SG 1229 ATOM 1229 CE1
TYR 150 24.184 63.175 -17.277 1.00 0.12 1SG 1230 ATOM 1230 CE2 TYR
150 24.140 64.607 -15.380 1.00 0.12 1SG 1231 ATOM 1231 CZ TYR 150
24.186 64.441 -16.741 1.00 0.12 1SG 1232 ATOM 1232 OH TYR 150
24.236 65.569 -17.586 1.00 0.12 1SG 1233 ATOM 1233 C TYR 150 26.154
60.142 -15.092 1.00 0.12 1SG 1234 ATOM 1234 O TYR 150 27.127 60.786
-15.483 1.00 0.12 1SG 1235 ATOM 1235 N CYS 151 25.714 59.054
-15.747 1.00 0.27 1SG 1236 ATOM 1236 CA CYS 151 26.449 58.615
-16.891 1.00 0.27 1SG 1237 ATOM 1237 CB CYS 151 27.202 57.301
-16.613 1.00 0.27 1SG 1238 ATOM 1238 SG CYS 151 28.205 56.708
-18.002 1.00 0.27 1SG 1239 ATOM 1239 C CYS 151 25.494 58.381
-18.012 1.00 0.27 1SG 1240 ATOM 1240 O CYS 151 24.314 58.113
-17.797 1.00 0.27 1SG 1241 ATOM 1241 N THR 152 25.991 58.533
-19.254 1.00 0.37 1SG 1242 ATOM 1242 CA THR 152 25.213 58.239
-20.419 1.00 0.37 1SG 1243 ATOM 1243 CB THR 152 24.881 59.420
-21.283 1.00 0.37 1SG 1244 ATOM 1244 OG1 THR 152 26.039 60.203
-21.521 1.00 0.37 1SG 1245 ATOM 1245 CG2 THR 152 23.764 60.239
-20.631 1.00 0.37 1SG 1246 ATOM 1246 C THR 152 25.993 57.273
-21.235 1.00 0.37 1SG 1247 ATOM 1247 O THR 152 27.222 57.258
-21.206 1.00 0.37 1SG 1248 ATOM 1248 N GLY 153 25.276 56.407
-21.972 1.00 0.21 1SG 1249 ATOM 1249 CA GLY 153 25.949 55.443
-22.782 1.00 0.21 1SG 1250 ATOM 1250 C GLY 153 24.927 54.865
-23.693 1.00 0.21 1SG 1251 ATOM 1251 O GLY 153 23.727 54.978
-23.449 1.00 0.21 1SG 1252 ATOM 1252 N LYS 154 25.384 54.221
-24.781 1.00 0.12 1SG 1253 ATOM 1253 CA LYS 154 24.429 53.670
-25.687 1.00 0.12 1SG 1254 ATOM 1254 CB LYS 154 24.681 54.054
-27.152 1.00 0.12 1SG 1255 ATOM 1255 CG LYS 154 24.557 55.554
-27.414 1.00 0.12 1SG 1256 ATOM 1256 CD LYS 154 25.103 55.976
-28.778 1.00 0.12 1SG 1257 ATOM 1257 CE LYS 154 24.981 57.477
-29.048 1.00 0.12 1SG 1258 ATOM 1258 NZ LYS 154 25.536 57.801
-30.382 1.00 0.12 1SG 1259 ATOM 1259 C LYS 154 24.520 52.188
-25.611 1.00 0.12 1SG 1260 ATOM 1260 O LYS 154 25.575 51.600
-25.848 1.00 0.12 1SG 1261 ATOM 1261 N VAL 155 23.395 51.548
-25.250 1.00 0.20 1SG 1262 ATOM 1262 CA VAL 155 23.342 50.123
-25.248 1.00 0.20 1SG 1263 ATOM 1263 CB VAL 155 22.778 49.535
-23.985 1.00 0.20 1SG 1264 ATOM 1264 CG1 VAL 155 23.730 49.874
-22.824 1.00 0.20 1SG 1265 ATOM 1265 CG2 VAL 155 21.347 50.064
-23.790 1.00 0.20 1SG 1266 ATOM 1266 C VAL 155 22.424 49.793
-26.367 1.00 0.20 1SG 1267 ATOM 1267 O VAL 155 21.364 50.401
-26.514 1.00 0.20 1SG 1268 ATOM 1268 N TRP 156 22.830 48.847
-27.226 1.00 0.33 1SG 1269 ATOM 1269 CA TRP 156 21.988 48.552
-28.338 1.00 0.33 1SG 1270 ATOM 1270 CB TRP 156 20.541 48.207
-27.940 1.00 0.33 1SG 1271 ATOM 1271 CG TRP 156 20.416 46.980
-27.065 1.00 0.33 1SG 1272 ATOM 1272 CD2 TRP 156 20.349 45.628
-27.548 1.00 0.33 1SG 1273 ATOM 1273 CD1 TRP 156 20.351 46.905
-25.705 1.00 0.33 1SG 1274 ATOM 1274 NE1 TRP 156 20.250 45.593
-25.308 1.00 0.33 1SG 1275 ATOM 1275 CE2 TRP 156 20.248 44.795
-26.433 1.00 0.33 1SG 1276 ATOM 1276 CE3 TRP 156 20.371 45.122
-28.816 1.00 0.33 1SG 1277 ATOM 1277 CZ2 TRP 156 20.169 43.438
-26.570 1.00 0.33 1SG 1278 ATOM 1278 CZ3 TRP 156 20.290 43.752
-28.949 1.00 0.33 1SG 1279 ATOM 1279 CH2 TRP 156 20.191 42.926
-27.848 1.00 0.33 1SG 1280 ATOM 1280 C TRP 156 21.971 49.807
-29.139 1.00 0.33 1SG 1281 ATOM 1281 O TRP 156 22.916 50.595
-29.101 1.00 0.33 1SG 1282 ATOM 1282 N GLN 157 20.880 50.014
-29.892 1.00 0.49 1SG 1283 ATOM 1283 CA GLN 157 20.742 51.178
-30.711 1.00 0.49 1SG 1284 ATOM 1284 CB GLN 157 19.491 51.114
-31.599 1.00 0.49 1SG 1285 ATOM 1285 CG GLN 157 19.421 49.846
-32.447 1.00 0.49 1SG 1286 ATOM 1286 CD GLN 157 20.718 49.744
-33.227 1.00 0.49 1SG 1287 ATOM 1287 OE1 GLN 157 21.154 50.709
-33.851 1.00 0.49 1SG 1288 ATOM 1288 NE2 GLN 157 21.358 48.547
-33.180 1.00 0.49 1SG 1289 ATOM 1289 C GLN 157 20.571 52.382
-29.842 1.00 0.49 1SG 1290 ATOM 1290 O GLN 157 21.157 53.433
-30.097 1.00 0.49 1SG 1291 ATOM 1291 N LEU 158 19.769 52.242
-28.769 1.00 0.41 1SG 1292 ATOM 1292 CA LEU 158 19.383 53.372
-27.974 1.00 0.41 1SG 1293 ATOM 1293 CB LEU 158 18.139 53.117
-27.106 1.00 0.41 1SG 1294 ATOM 1294 CG LEU 158 16.869 52.845
-27.933 1.00 0.41 1SG 1295 ATOM 1295 CD2 LEU 158 17.020 51.571
-28.782 1.00 0.41 1SG 1296 ATOM 1296 CD1 LEU 158 16.466 54.076
-28.762 1.00 0.41 1SG 1297 ATOM 1297 C LEU 158 20.476 53.827
-27.067 1.00 0.41 1SG 1298 ATOM 1298 O LEU 158 21.433 53.107
-26.787 1.00 0.41 1SG 1299 ATOM 1299 N ASP 159 20.333 55.089
-26.610 1.00 0.19 1SG 1300 ATOM 1300 CA ASP 159 21.230 55.721
-25.689 1.00 0.19 1SG 1301 ATOM 1301 CB ASP 159 21.643 57.142
-26.138 1.00 0.19 1SG 1302 ATOM 1302 CG ASP 159 22.711 57.750
-25.227 1.00 0.19 1SG 1303 ATOM 1303 OD1 ASP 159 22.869 57.289
-24.067 1.00 0.19 1SG 1304 ATOM 1304 OD2 ASP 159 23.385 58.706
-25.697 1.00 0.19 1SG 1305 ATOM 1305 C ASP 159 20.460 55.850
-24.413 1.00 0.19 1SG 1306 ATOM 1306 O ASP 159 19.280 56.200
-24.424 1.00 0.19 1SG 1307 ATOM 1307 N TYR 160 21.100 55.535
-23.272 1.00 0.11 1SG 1308 ATOM 1308 CA TYR 160 20.407 55.630
-22.022 1.00 0.11 1SG 1309 ATOM 1309 CB TYR 160 20.273 54.289
-21.280 1.00 0.11 1SG 1310 ATOM 1310 CG TYR 160 19.308 53.437
-22.031 1.00 0.11 1SG 1311 ATOM 1311 CD1 TYR 160 19.672 52.822
-23.207 1.00 0.11 1SG 1312 ATOM 1312 CD2 TYR 160 18.036 53.241
-21.545 1.00 0.11 1SG 1313 ATOM 1313 CE1 TYR 160 18.776 52.036
-23.892 1.00 0.11 1SG 1314 ATOM 1314 CE2 TYR 160 17.135 52.456
-22.225 1.00 0.11 1SG 1315 ATOM 1315 CZ TYR 160 17.506 51.852
-23.402 1.00 0.11 1SG 1316 ATOM 1316 OH TYR 160 16.587 51.045
-24.106 1.00 0.11 1SG 1317 ATOM 1317 C TYR 160 21.173 56.539
-21.122 1.00 0.11 1SG 1318 ATOM 1318 O TYR 160 22.366 56.770
-21.316 1.00 0.11 1SG 1319 ATOM 1319 N GLU 161 20.472 57.112
-20.124 1.00 0.12 1SG 1320 ATOM 1320 CA GLU 161 21.125 57.944
-19.159 1.00 0.12 1SG 1321 ATOM 1321 CB GLU 161 20.623 59.399
-19.119 1.00 0.12 1SG 1322 ATOM 1322 CG GLU 161 21.484 60.299
-18.228 1.00 0.12 1SG 1323 ATOM 1323 CD GLU 161 21.015 61.741
-18.382 1.00 0.12 1SG 1324 ATOM 1324 OE1 GLU 161 19.816 62.015
-18.112 1.00 0.12 1SG 1325 ATOM 1325 OE2 GLU 161 21.860 62.592
-18.773 1.00 0.12 1SG 1326 ATOM 1326 C GLU 161 20.870 57.327
-17.824 1.00 0.12 1SG 1327 ATOM 1327 O GLU 161 19.815 56.739
-17.589 1.00 0.12 1SG 1328 ATOM 1328 N SER 162 21.860 57.419
-16.919 1.00 0.11 1SG 1329 ATOM 1329 CA SER 162 21.729 56.834
-15.619 1.00 0.11 1SG 1330 ATOM 1330 CB SER 162 23.065 56.348
-15.030 1.00 0.11 1SG 1331 ATOM 1331 OG SER 162 22.857 55.774
-13.748 1.00 0.11 1SG 1332 ATOM 1332 C SER 162 21.172 57.852
-14.688 1.00 0.11 1SG 1333 ATOM 1333 O SER 162 21.083 59.035
-15.012 1.00 0.11 1SG 1334 ATOM 1334 N GLU 163 20.754 57.391
-13.495 1.00 0.13 1SG 1335 ATOM 1335 CA GLU 163 20.245 58.279
-12.496 1.00 0.13 1SG 1336 ATOM 1336 CB GLU 163 19.399 57.559
-11.433 1.00 0.13 1SG 1337 ATOM 1337 CG GLU 163 20.166 56.464
-10.691 1.00 0.13 1SG 1338 ATOM 1338 CD GLU 163 19.148 55.604
-9.957 1.00 0.13 1SG 1339 ATOM 1339 OE1 GLU 163 18.185 55.142
-10.626 1.00 0.13 1SG 1340 ATOM 1340 OE2 GLU 163 19.315 55.396
-8.726 1.00 0.13 1SG 1341 ATOM 1341 C GLU 163 21.427 58.899 -11.832
1.00 0.13 1SG 1342 ATOM 1342 O GLU 163 22.501 58.306 -11.741 1.00
0.13 1SG 1343 ATOM 1343 N PRO 164 21.247 60.108 -11.395 1.00 0.13
1SG 1344 ATOM 1344 CA PRO 164 22.340 60.787 -10.760 1.00 0.13 1SG
1345 ATOM 1345 CD PRO 164 20.412 61.023 -12.159 1.00 0.13 1SG 1346
ATOM 1346 CB PRO 164 21.993 62.271 -10.814 1.00 0.13 1SG 1347 ATOM
1347 CG PRO 164 21.098 62.393 -12.057 1.00 0.13 1SG 1348 ATOM 1348
C PRO 164 22.582 60.282 -9.378 1.00 0.13 1SG 1349 ATOM 1349 O PRO
164 21.649 59.793 -8.745 1.00 0.13 1SG 1350 ATOM 1350 N LEU 165
23.838 60.371 -8.902 1.00 0.11 1SG 1351 ATOM 1351 CA LEU 165 24.145
59.970 -7.563 1.00 0.11 1SG 1352 ATOM 1352 CB LEU 165 25.043 58.726
-7.474 1.00 0.11 1SG 1353 ATOM 1353 CG LEU 165 24.393 57.464 -8.071
1.00 0.11 1SG 1354 ATOM 1354 CD2 LEU 165 22.957 57.275 -7.560 1.00
0.11 1SG 1355 ATOM 1355 CD1 LEU 165 25.276 56.226 -7.849 1.00 0.11
1SG 1356 ATOM 1356 C LEU 165 24.887 61.114 -6.959 1.00 0.11 1SG
1357 ATOM 1357 O LEU 165 25.628 61.811 -7.650 1.00 0.11 1SG 1358
ATOM 1358 N
ASN 166 24.696 61.358 -5.650 1.00 0.10 1SG 1359 ATOM 1359 CA ASN
166 25.384 62.468 -5.065 1.00 0.10 1SG 1360 ATOM 1360 CB ASN 166
24.587 63.214 -3.980 1.00 0.10 1SG 1361 ATOM 1361 CG ASN 166 23.476
64.012 -4.647 1.00 0.10 1SG 1362 ATOM 1362 OD1 ASN 166 23.226
63.888 -5.845 1.00 0.10 1SG 1363 ATOM 1363 ND2 ASN 166 22.794
64.872 -3.846 1.00 0.10 1SG 1364 ATOM 1364 C ASN 166 26.621 61.954
-4.414 1.00 0.10 1SG 1365 ATOM 1365 O ASN 166 26.569 61.093 -3.537
1.00 0.10 1SG 1366 ATOM 1366 N ILE 167 27.780 62.472 -4.857 1.00
0.22 1SG 1367 ATOM 1367 CA ILE 167 29.021 62.087 -4.261 1.00 0.22
1SG 1368 ATOM 1368 CB ILE 167 30.024 61.566 -5.249 1.00 0.22 1SG
1369 ATOM 1369 CG2 ILE 167 31.364 61.380 -4.515 1.00 0.22 1SG 1370
ATOM 1370 CG1 ILE 167 29.500 60.285 -5.918 1.00 0.22 1SG 1371 ATOM
1371 CD1 ILE 167 30.315 59.855 -7.138 1.00 0.22 1SG 1372 ATOM 1372
C ILE 167 29.588 63.326 -3.662 1.00 0.22 1SG 1373 ATOM 1373 O ILE
167 29.637 64.372 -4.306 1.00 0.22 1SG 1374 ATOM 1374 N THR 168
30.016 63.251 -2.391 1.00 0.48 1SG 1375 ATOM 1375 CA THR 168 30.555
64.431 -1.790 1.00 0.48 1SG 1376 ATOM 1376 CB THR 168 29.789 64.932
-0.603 1.00 0.48 1SG 1377 ATOM 1377 OG1 THR 168 29.672 63.906 0.372
1.00 0.48 1SG 1378 ATOM 1378 CG2 THR 168 28.411 65.422 -1.054 1.00
0.48 1SG 1379 ATOM 1379 C THR 168 31.917 64.138 -1.288 1.00 0.48
1SG 1380 ATOM 1380 O THR 168 32.229 63.015 -0.894 1.00 0.48 1SG
1381 ATOM 1381 N VAL 169 32.784 65.163 -1.315 1.00 0.55 1SG 1382
ATOM 1382 CA VAL 169 34.061 64.960 -0.722 1.00 0.55 1SG 1383 ATOM
1383 CB VAL 169 35.186 65.749 -1.338 1.00 0.55 1SG 1384 ATOM 1384
CG1 VAL 169 35.366 65.272 -2.785 1.00 0.55 1SG 1385 ATOM 1385 CG2
VAL 169 34.903 67.254 -1.220 1.00 0.55 1SG 1386 ATOM 1386 C VAL 169
33.871 65.395 0.689 1.00 0.55 1SG 1387 ATOM 1387 O VAL 169 33.425
66.509 0.960 1.00 0.55 1SG 1388 ATOM 1388 N ILE 170 34.178 64.492
1.631 1.00 0.56 1SG 1389 ATOM 1389 CA ILE 170 33.974 64.776 3.017
1.00 0.56 1SG 1390 ATOM 1390 CB ILE 170 34.332 63.609 3.909 1.00
0.56 1SG 1391 ATOM 1391 CG2 ILE 170 35.849 63.375 3.822 1.00 0.56
1SG 1392 ATOM 1392 CG1 ILE 170 33.816 63.807 5.348 1.00 0.56 1SG
1393 ATOM 1393 CD1 ILE 170 34.469 64.961 6.108 1.00 0.56 1SG 1394
ATOM 1394 C ILE 170 34.831 65.949 3.356 1.00 0.56 1SG 1395 ATOM
1395 O ILE 170 34.414 66.833 4.103 1.00 0.56 1SG 1396 ATOM 1396 N
LYS 171 36.052 65.993 2.792 1.00 0.52 1SG 1397 ATOM 1397 CA LYS 171
36.958 67.069 3.063 1.00 0.52 1SG 1398 ATOM 1398 CB LYS 171 38.241
66.953 2.216 1.00 0.52 1SG 1399 ATOM 1399 CG LYS 171 39.411 67.838
2.650 1.00 0.52 1SG 1400 ATOM 1400 CD LYS 171 39.151 69.334 2.515
1.00 0.52 1SG 1401 ATOM 1401 CE LYS 171 40.396 70.193 2.745 1.00
0.52 1SG 1402 ATOM 1402 NZ LYS 171 40.985 69.879 4.064 1.00 0.52
1SG 1403 ATOM 1403 C LYS 171 36.237 68.329 2.704 1.00 0.52 1SG 1404
ATOM 1404 O LYS 171 35.772 68.490 1.578 1.00 0.52 1SG 1405 ATOM
1405 N ALA 172 36.106 69.253 3.677 1.00 0.31 1SG 1406 ATOM 1406 CA
ALA 172 35.369 70.457 3.427 1.00 0.31 1SG 1407 ATOM 1407 CB ALA 172
34.326 70.764 4.515 1.00 0.31 1SG 1408 ATOM 1408 C ALA 172 36.321
71.645 3.385 1.00 0.31 1SG 1409 ATOM 1409 O ALA 172 35.863 72.767
3.726 1.00 0.31 1SG 1410 ATOM 1410 OXT ALA 172 37.507 71.460 3.008
1.00 0.31 1SG 1411 END
[0145]
4TABLE 4 REMARK Model of the Fc Epsilon Receptor I `dimer`; V.C.
Epa, 28/08/98. ATOM 1 N VAL A 1 35.035 67.423 -3.312 1.00 0.14 N1+
ATOM 2 CA VAL A 1 36.312 67.082 -2.644 1.00 0.14 C ATOM 3 C VAL A 1
36.557 67.737 -1.314 1.00 0.14 C ATOM 4 O VAL A 1 37.357 67.213
-0.542 1.00 0.14 O ATOM 5 CB VAL A 1 37.484 67.327 -3.566 1.00 0.14
C ATOM 6 CG1 VAL A 1 37.364 66.351 -4.747 1.00 0.14 C ATOM 7 CG2
VAL A 1 37.528 68.799 -4.005 1.00 0.14 C ATOM 8 1H VAL A 1 34.869
66.862 -4.138 1.00 0.00 H ATOM 9 2H VAL A 1 34.241 67.268 -2.703
1.00 0.00 H ATOM 10 3H VAL A 1 34.995 68.390 -3.602 1.00 0.00 H
ATOM 11 HA VAL A 1 36.235 66.006 -2.400 1.00 0.00 H ATOM 12 HB VAL
A 1 38.411 67.089 -3.011 1.00 0.00 H ATOM 13 1HG1 VAL A 1 38.229
66.431 -5.429 1.00 0.00 H ATOM 14 2HG1 VAL A 1 37.326 65.302 -4.406
1.00 0.00 H ATOM 15 3HG1 VAL A 1 36.463 66.547 -5.351 1.00 0.00 H
ATOM 16 1HG2 VAL A 1 38.228 68.883 -4.860 1.00 0.00 H ATOM 17 2HG2
VAL A 1 36.576 69.170 -4.412 1.00 0.00 H ATOM 18 3HG2 VAL A 1
38.001 69.445 -3.249 1.00 0.00 H ATOM 19 N PRO A 2 35.933 68.836
-0.959 1.00 0.15 N ATOM 20 CA PRO A 2 36.195 69.325 0.363 1.00 0.15
C ATOM 21 C PRO A 2 35.493 68.456 1.350 1.00 0.15 C ATOM 22 O PRO A
2 34.546 67.769 0.973 1.00 0.15 O ATOM 23 CB PRO A 2 35.731 70.778
0.391 1.00 0.15 C ATOM 24 CG PRO A 2 35.897 71.231 -1.067 1.00 0.15
C ATOM 25 CD PRO A 2 35.709 69.942 -1.884 1.00 0.15 C ATOM 26 HA
PRO A 2 37.285 69.336 0.558 1.00 0.00 H ATOM 27 1HB PRO A 2 36.304
71.370 1.118 1.00 0.00 H ATOM 28 2HB PRO A 2 34.669 70.840 0.677
1.00 0.00 H ATOM 29 1HG PRO A 2 36.917 71.626 -1.212 1.00 0.00 H
ATOM 30 2HG PRO A 2 35.203 72.033 -1.366 1.00 0.00 H ATOM 31 1HD
PRO A 2 34.667 69.886 -2.239 1.00 0.00 H ATOM 32 2HD PRO A 2 36.339
70.042 -2.732 1.00 0.00 H ATOM 33 N GLN A 3 35.941 68.473 2.617
1.00 0.19 N ATOM 34 CA GLN A 3 35.329 67.651 3.614 1.00 0.19 C ATOM
35 C GLN A 3 33.901 68.073 3.703 1.00 0.19 C ATOM 36 O GLN A 3
33.553 69.196 3.339 1.00 0.19 O ATOM 37 CB GLN A 3 35.986 67.803
4.996 1.00 0.19 C ATOM 38 CG GLN A 3 35.493 66.802 6.040 1.00 0.19
C ATOM 39 CD GLN A 3 36.327 67.022 7.293 1.00 0.19 C ATOM 40 OE1
GLN A 3 36.930 68.079 7.467 1.00 0.19 O ATOM 41 NE2 GLN A 3 36.374
65.997 8.185 1.00 0.19 N ATOM 42 H GLN A 3 36.686 69.083 2.909 1.00
0.00 H ATOM 43 HA GLN A 3 35.401 66.596 3.289 1.00 0.00 H ATOM 44
1HB GLN A 3 35.828 68.836 5.351 1.00 0.00 H ATOM 45 2HB GLN A 3
37.076 67.663 4.874 1.00 0.00 H ATOM 46 1HG GLN A 3 35.596 65.769
5.669 1.00 0.00 H ATOM 47 2HG GLN A 3 34.444 66.987 6.303 1.00 0.00
H ATOM 48 1HE2 GLN A 3 36.281 65.050 7.857 1.00 0.00 H ATOM 49 2HE2
GLN A 3 37.049 66.168 8.921 1.00 0.00 H ATOM 50 N LYS A 4 33.024
67.165 4.172 1.00 0.23 N ATOM 51 CA LYS A 4 31.626 67.476 4.219
1.00 0.23 C ATOM 52 C LYS A 4 31.282 67.937 5.594 1.00 0.23 C ATOM
53 O LYS A 4 31.667 67.348 6.603 1.00 0.23 O ATOM 54 CB LYS A 4
30.722 66.273 3.904 1.00 0.23 C ATOM 55 CG LYS A 4 30.861 65.765
2.467 1.00 0.23 C ATOM 56 CD LYS A 4 30.229 64.389 2.241 1.00 0.23
C ATOM 57 CE LYS A 4 31.032 63.242 2.856 1.00 0.23 C ATOM 58 NZ LYS
A 4 30.320 61.959 2.659 1.00 0.23 N1+ ATOM 59 H LYS A 4 33.282
66.218 4.377 1.00 0.00 H ATOM 60 HA LYS A 4 31.442 68.204 3.416
1.00 0.00 H ATOM 61 1HB LYS A 4 29.665 66.523 4.096 1.00 0.00 H
ATOM 62 2HB LYS A 4 30.952 65.468 4.623 1.00 0.00 H ATOM 63 1HG LYS
A 4 31.919 65.737 2.150 1.00 0.00 H ATOM 64 2HG LYS A 4 30.360
66.486 1.801 1.00 0.00 H ATOM 65 1HD LYS A 4 30.132 64.216 1.154
1.00 0.00 H ATOM 66 2HD LYS A 4 29.200 64.402 2.645 1.00 0.00 H
ATOM 67 1HE LYS A 4 31.168 63.364 3.942 1.00 0.00 H ATOM 68 2HE LYS
A 4 32.027 63.149 2.391 1.00 0.00 H ATOM 69 1HZ LYS A 4 30.819
61.167 3.042 1.00 0.00 H ATOM 70 2HZ LYS A 4 29.420 61.981 3.134
1.00 0.00 H ATOM 71 3HZ LYS A 4 30.140 61.756 1.685 1.00 0.00 H
ATOM 72 N PRO A 5 30.550 69.013 5.616 1.00 0.25 N ATOM 73 CA PRO A
5 30.108 69.615 6.840 1.00 0.25 C ATOM 74 C PRO A 5 29.273 68.587
7.522 1.00 0.25 C ATOM 75 O PRO A 5 28.730 67.719 6.839 1.00 0.25 O
ATOM 76 CB PRO A 5 29.231 70.784 6.411 1.00 0.25 C ATOM 77 CG PRO A
5 28.592 70.257 5.112 1.00 0.25 C ATOM 78 CD PRO A 5 29.678 69.350
4.507 1.00 0.25 C ATOM 79 HA PRO A 5 30.972 69.906 7.456 1.00 0.00
H ATOM 80 1HB PRO A 5 29.730 71.743 6.357 1.00 0.00 H ATOM 81 2HB
PRO A 5 28.453 70.955 7.178 1.00 0.00 H ATOM 82 1HG PRO A 5 28.174
70.972 4.412 1.00 0.00 H ATOM 83 2HG PRO A 5 27.910 69.522 5.421
1.00 0.00 H ATOM 84 1HD PRO A 5 29.236 68.469 4.044 1.00 0.00 H
ATOM 85 2HD PRO A 5 30.320 69.821 3.774 1.00 0.00 H ATOM 86 N LYS A
6 29.172 68.639 8.861 1.00 0.35 N ATOM 87 CA LYS A 6 28.336 67.685
9.520 1.00 0.35 C ATOM 88 C LYS A 6 27.209 68.437 10.136 1.00 0.35
C ATOM 89 O LYS A 6 27.391 69.533 10.666 1.00 0.35 O ATOM 90 CB LYS
A 6 29.033 66.897 10.641 1.00 0.35 C ATOM 91 CG LYS A 6 30.016
65.843 10.127 1.00 0.35 C ATOM 92 CD LYS A 6 31.243 66.430 9.427
1.00 0.35 C ATOM 93 CE LYS A 6 32.218 65.365 8.920 1.00 0.35 C ATOM
94 NZ LYS A 6 33.370 66.010 8.253 1.00 0.35 N1+ ATOM 95 H LYS A 6
29.530 69.396 9.434 1.00 0.00 H ATOM 96 HA LYS A 6 27.947 66.943
8.805 1.00 0.00 H ATOM 97 1HB LYS A 6 28.241 66.394 11.226 1.00
0.00 H ATOM 98 2HB LYS A 6 29.641 67.443 11.336 1.00 0.00 H ATOM 99
1HG LYS A 6 29.498 65.154 9.434 1.00 0.00 H ATOM 100 2HG LYS A 6
30.343 65.221 10.981 1.00 0.00 H ATOM 101 1HD LYS A 6 31.763 67.118
10.116 1.00 0.00 H ATOM 102 2HD LYS A 6 30.880 67.022 8.600 1.00
0.00 H ATOM 103 1HE LYS A 6 31.740 64.699 8.183 1.00 0.00 H ATOM
104 2HE LYS A 6 32.610 64.746 9.743 1.00 0.00 H ATOM 105 1HZ LYS A
6 33.989 65.352 7.805 1.00 0.00 H ATOM 106 2HZ LYS A 6 33.032
66.644 7.532 1.00 0.00 H ATOM 107 3HZ LYS A 6 33.939 66.555 8.889
1.00 0.00 H ATOM 108 N VAL A 7 25.995 67.867 10.051 1.00 0.35 N
ATOM 109 CA VAL A 7 24.871 68.517 10.651 1.00 0.35 C ATOM 110 C VAL
A 7 24.592 67.792 11.922 1.00 0.35 C ATOM 111 O VAL A 7 24.524
66.564 11.950 1.00 0.35 O ATOM 112 CB VAL A 7 23.627 68.483 9.806
1.00 0.35 C ATOM 113 CG1 VAL A 7 23.210 67.019 9.585 1.00 0.35 C
ATOM 114 CG2 VAL A 7 22.552 69.335 10.499 1.00 0.35 C ATOM 115 H
VAL A 7 25.821 66.977 9.615 1.00 0.00 H ATOM 116 HA VAL A 7 25.120
69.575 10.831 1.00 0.00 H ATOM 117 HB VAL A 7 23.863 68.941 8.827
1.00 0.00 H ATOM 118 1HG1 VAL A 7 22.471 66.965 8.765 1.00 0.00 H
ATOM 119 2HG1 VAL A 7 24.031 66.350 9.285 1.00 0.00 H ATOM 120 3HG1
VAL A 7 22.693 66.586 10.456 1.00 0.00 H ATOM 121 1HG2 VAL A 7
21.678 69.500 9.847 1.00 0.00 H ATOM 122 2HG2 VAL A 7 22.176 68.844
11.412 1.00 0.00 H ATOM 123 3HG2 VAL A 7 22.944 70.315 10.791 1.00
0.00 H ATOM 124 N SER A 8 24.448 68.548 13.023 1.00 0.17 N ATOM 125
CA SER A 8 24.199 67.929 14.287 1.00 0.17 C ATOM 126 C SER A 8
22.807 68.274 14.689 1.00 0.17 C ATOM 127 O SER A 8 22.347 69.396
14.481 1.00 0.17 O ATOM 128 CB SER A 8 25.131 68.420 15.407 1.00
0.17 C ATOM 129 OG SER A 8 24.819 67.761 16.625 1.00 0.17 O ATOM
130 H SER A 8 24.612 69.550 13.018 1.00 0.00 H ATOM 131 HA SER A 8
24.337 66.838 14.216 1.00 0.00 H ATOM 132 1HB SER A 8 25.070 69.509
15.536 1.00 0.00 H ATOM 133 2HB SER A 8 26.175 68.173 15.162 1.00
0.00 H ATOM 134 HG SER A 8 24.240 68.346 17.142 1.00 0.00 H ATOM
135 N LEU A 9 22.092 67.295 15.268 1.00 0.11 N ATOM 136 CA LEU A 9
20.747 67.539 15.682 1.00 0.11 C ATOM 137 C LEU A 9 20.696 67.369
17.164 1.00 0.11 C ATOM 138 O LEU A 9 21.139 66.354 17.700 1.00
0.11 O ATOM 139 CB LEU A 9 19.749 66.532 15.080 1.00 0.11 C ATOM
140 CG LEU A 9 18.287 66.745 15.512 1.00 0.11 C ATOM 141 CD1 LEU A
9 17.732 68.081 14.988 1.00 0.11 C ATOM 142 CD2 LEU A 9 17.418
65.542 15.111 1.00 0.11 C ATOM 143 H LEU A 9 22.476 66.399 15.518
1.00 0.00 H ATOM 144 HA LEU A 9 20.438 68.549 15.382 1.00 0.00 H
ATOM 145 1HB LEU A 9 20.066 65.510 15.354 1.00 0.00 H ATOM 146 2HB
LEU A 9 19.815 66.582 13.978 1.00 0.00 H ATOM 147 HG LEU A 9 18.324
66.981 16.546 1.00 0.00 H ATOM 148 1HD1 LEU A 9 16.651 68.121
15.191 1.00 0.00 H ATOM 149 2HD1 LEU A 9 18.211 68.929 15.488 1.00
0.00 H ATOM 150 3HD1 LEU A 9 17.848 68.122 13.899 1.00 0.00 H ATOM
151 1HD2 LEU A 9 16.368 65.690 15.400 1.00 0.00 H ATOM 152 2HD2 LEU
A 9 17.440 65.417 14.015 1.00 0.00 H ATOM 153 3HD2 LEU A 9 17.775
64.610 15.558 1.00 0.00 H ATOM 154 N ASN A 10 20.176 68.388 17.872
1.00 0.17 N ATOM 155 CA ASN A 10 20.046 68.267 19.291 1.00 0.17 C
ATOM 156 C ASN A 10 18.653 68.686 19.623 1.00 0.17 C ATOM 157 O ASN
A 10 18.240 69.797 19.295 1.00 0.17 O ATOM 158 CB ASN A 10 20.992
69.194 20.070 1.00 0.17 C ATOM 159 CG ASN A 10 22.415 68.721 19.819
1.00 0.17 C ATOM 160 OD1 ASN A 10 23.167 69.361 19.086 1.00 0.17 O
ATOM 161 ND2 ASN A 10 22.798 67.574 20.443 1.00 0.17 N ATOM 162 H
ASN A 10 19.900 69.270 17.449 1.00 0.00 H ATOM 163 HA ASN A 10
20.331 67.257 19.576 1.00 0.00 H ATOM 164 1HB ASN A 10 20.746
69.138 21.144 1.00 0.00 H ATOM 165 2HB ASN A 10 20.917 70.239
19.756 1.00 0.00 H ATOM 166 1HD2 ASN A 10 22.193 67.061 21.052 1.00
0.00 H ATOM 167 2HD2 ASN A 10 23.732 67.251 20.255 1.00 0.00 H ATOM
168 N PRO A 11 17.897 67.828 20.245 1.00 0.35 N ATOM 169 CA PRO A
11 18.370 66.510 20.559 1.00 0.35 C ATOM 170 C PRO A 11 18.404
65.700 19.305 1.00 0.35 C ATOM 171 O PRO A 11 17.867 66.139 18.290
1.00 0.35 O ATOM 172 CB PRO A 11 17.403 65.958 21.604 1.00 0.35 C
ATOM 173 CG PRO A 11 16.865 67.215 22.308 1.00 0.35 C ATOM 174 CD
PRO A 11 16.938 68.307 21.228 1.00 0.35 C ATOM 175 HA PRO A 11
19.324 66.603 21.103 1.00 0.00 H ATOM 176 1HB PRO A 11 17.862
65.215 22.273 1.00 0.00 H ATOM 177 2HB PRO A 11 16.571 65.464
21.082 1.00 0.00 H ATOM 178 1HG PRO A 11 17.522 67.473 23.155 1.00
0.00 H ATOM 179 2HG PRO A 11 15.851 67.097 22.721 1.00 0.00 H ATOM
180 1HD PRO A 11 15.961 68.435 20.733 1.00 0.00 H ATOM 181 2HD PRO
A 11 17.234 69.288 21.626 1.00 0.00 H ATOM 182 N PRO A 12 19.030
64.557 19.364 1.00 0.52 N ATOM 183 CA PRO A 12 19.156 63.710 18.209
1.00 0.52 C ATOM 184 C PRO A 12 17.853 63.101 17.809 1.00 0.52 C
ATOM 185 O PRO A 12 17.789 62.501 16.737 1.00 0.52 O ATOM 186 CB
PRO A 12 20.215 62.672 18.568 1.00 0.52 C ATOM 187 CG PRO A 12
21.088 63.386 19.613 1.00 0.52 C ATOM 188 CD PRO A 12 20.128 64.371
20.299 1.00 0.52 C ATOM 189 HA PRO A 12 19.493 64.305 17.344 1.00
0.00 H ATOM 190 1HB PRO A 12 20.766 62.306 17.688 1.00 0.00 H ATOM
191 2HB PRO A 12 19.733 61.793 19.029 1.00 0.00 H ATOM 192 1HG PRO
A 12 21.889 63.941 19.096 1.00 0.00 H ATOM 193 2HG PRO A 12 21.583
62.706 20.323 1.00 0.00 H ATOM 194 1HD PRO A 12 19.742 63.953
21.242 1.00 0.00 H ATOM 195 2HD PRO A 12 20.663 65.299 20.521 1.00
0.00 H ATOM 196 N TRP A 13 16.809 63.231 18.646 1.00 0.35 N ATOM
197 CA TRP A 13 15.559 62.588 18.359 1.00 0.35 C ATOM 198 C TRP A
13 15.107 63.016 16.998 1.00 0.35 C ATOM 199 O TRP A 13 14.934
64.204 16.731 1.00 0.35 O ATOM 200 CB TRP A 13 14.454 62.959 19.361
1.00 0.35 C ATOM 201 CG TRP A 13 14.839 62.683 20.795 1.00 0.35 C
ATOM 202 CD1 TRP A 13 14.961 63.559 21.833 1.00 0.35 C ATOM 203 CD2
TRP A 13 15.219 61.396 21.302 1.00 0.35 C ATOM 204 NE1 TRP A 13
15.382 62.897 22.961 1.00 0.35 N ATOM 205 CE2 TRP A 13 15.549
61.564 22.647 1.00 0.35 C ATOM 206 CE3 TRP A 13 15.297 60.175
20.695 1.00 0.35 C ATOM 207 CZ2 TRP A 13 15.962 60.510 23.408 1.00
0.35 C ATOM 208 CZ3 TRP A 13 15.707 59.110 21.468 1.00 0.35 C ATOM
209 CH2 TRP A 13 16.031 59.276 22.798 1.00 0.35 C ATOM 210 H TRP A
13 16.881 63.779 19.484 1.00 0.00 H ATOM 211 HA TRP A 13 15.723
61.498 18.375 1.00 0.00 H ATOM 212 1HB TRP A 13 13.543 62.407
19.077 1.00 0.00 H ATOM 213 2HB TRP A 13 14.206 64.025 19.251 1.00
0.00 H ATOM 214 HD1 TRP A 13 14.739 64.617 21.844 1.00 0.00 H ATOM
215 HE1 TRP A 13 15.809 63.343 23.741 1.00 0.00 H ATOM 216 HE3 TRP
A 13 15.045 60.031 19.655 1.00 0.00 H ATOM 217 HZ2 TRP A 13 16.229
60.748 24.420 1.00 0.00 H ATOM 218 HZ3 TRP A 13 15.795 58.114
21.062 1.00 0.00 H ATOM 219 HH2 TRP A 13 16.099 58.366 23.378 1.00
0.00 H ATOM 220 N ASN A 14 14.933 62.037 16.085 1.00 0.15 N ATOM
221 CA ASN A 14 14.506 62.327 14.747 1.00 0.15 C ATOM 222 C ASN A
14 13.076 62.758 14.777 1.00 0.15 C ATOM 223 O ASN A 14 12.681
63.681 14.064 1.00 0.15 O ATOM 224 CB ASN A 14 14.605 61.127 13.785
1.00 0.15 C ATOM 225 CG ASN A 14 13.588 60.064 14.181 1.00 0.15 C
ATOM 226 OD1 ASN A 14 13.408 59.751 15.357 1.00 0.15 O ATOM 227 ND2
ASN A 14 12.882 59.499 13.165 1.00 0.15 N ATOM 228 H ASN A 14
15.126 61.062 16.292 1.00 0.00 H ATOM 229 HA ASN A 14 15.111 63.154
14.342 1.00 0.00 H ATOM 230 1HB ASN A 14 15.612 60.678 13.806 1.00
0.00 H ATOM 231 2HB ASN A 14 14.421 61.501 12.763 1.00 0.00 H ATOM
232 1HD2 ASN A 14 12.990 59.778 12.202 1.00 0.00 H ATOM 233 2HD2
ASN A 14 12.220 58.777 13.379 1.00 0.00 H ATOM 234 N ARG A 15
12.257 62.093 15.615 1.00 0.13 N ATOM 235 CA ARG A 15 10.859 62.400
15.668 1.00 0.13 C ATOM 236 C ARG A 15 10.645 63.247 16.872 1.00
0.13 C ATOM 237 O ARG A 15 11.086 62.908 17.969 1.00 0.13 O ATOM
238 CB ARG A 15 9.961 61.164 15.860 1.00 0.13 C ATOM 239 CG ARG A
15 9.990 60.171 14.698 1.00 0.13 C ATOM 240 CD ARG A 15 9.087
58.956 14.925 1.00 0.13 C ATOM 241 NE ARG A 15 9.233 58.061 13.742
1.00 0.13 N1+ ATOM 242 CZ ARG A 15 8.137 57.682 13.023 1.00 0.13 C
ATOM 243 NH1 ARG A 15 6.892 58.097 13.396 1.00 0.13 N ATOM 244 NH2
ARG A 15 8.289 56.882 11.926 1.00 0.13 N ATOM 245 H ARG A 15 12.592
61.259 16.078 1.00 0.00 H ATOM 246 HA ARG A 15 10.563 62.903 14.736
1.00 0.00 H ATOM 247 1HB ARG A 15 8.996 61.516 16.214 1.00 0.00 H
ATOM 248 2HB ARG A 15 10.355 60.612 16.738 1.00 0.00 H ATOM 249 1HG
ARG A 15 11.007 59.776 14.648 1.00 0.00 H ATOM 250 2HG ARG A 15
9.785 60.645 13.726 1.00 0.00 H ATOM 251 1HD ARG A 15 8.048 59.228
15.153 1.00 0.00 H ATOM 252 2HD ARG A 15 9.459 58.433 15.807 1.00
0.00 H ATOM 253 HE ARG A 15 9.923 57.342 13.749 1.00 0.00 H ATOM
254 1HH1 ARG A 15 6.719 58.668 14.192 1.00 0.00 H ATOM 255 2HH1 ARG
A 15 6.069 57.748 12.956 1.00 0.00 H ATOM 256 1HH2 ARG A 15 7.535
56.853 11.277 1.00 0.00 H ATOM 257 2HH2 ARG A 15 9.189 56.912
11.491 1.00 0.00 H ATOM 258 N ILE A 16 9.959 64.390 16.699 1.00
0.12 N ATOM 259 CA ILE A 16 9.719 65.221 17.838 1.00 0.12 C ATOM
260 C ILE A 16 8.300 65.668 17.781 1.00 0.12 C ATOM 261 O ILE A 16
7.583 65.394 16.820 1.00 0.12 O ATOM 262 CB ILE A 16 10.558 66.467
17.883 1.00 0.12 C ATOM 263 CG1 ILE A 16 10.236 67.383 16.690 1.00
0.12 C ATOM 264 CG2 ILE A 16 12.035 66.048 17.972 1.00 0.12 C ATOM
265 CD1 ILE A 16 10.816 68.789 16.840 1.00 0.12 C ATOM 266 H ILE A
16 9.590 64.694 15.804 1.00 0.00 H ATOM 267 HA ILE A 16 9.806
64.637 18.761 1.00 0.00 H ATOM 268 HB ILE A 16 10.323 67.011 18.816
1.00 0.00 H ATOM 269 1HG1 ILE A 16 9.151 67.494 16.527 1.00 0.00 H
ATOM 270 2HG1 ILE A 16 10.633 66.927 15.766 1.00 0.00 H ATOM 271
1HG2 ILE A 16 12.707 66.907 18.128 1.00 0.00 H ATOM 272 2HG2 ILE A
16 12.205 65.359 18.814 1.00 0.00 H ATOM 273 3HG2 ILE A 16 12.376
65.543 17.052 1.00 0.00 H ATOM 274 1HD1 ILE A 16 10.934 69.273
15.860 1.00 0.00 H ATOM 275 2HD1 ILE A 16 10.156 69.429 17.440 1.00
0.00 H ATOM 276 3HD1 ILE A 16 11.792 68.758 17.336 1.00 0.00 H ATOM
277 N PHE A 17 7.862 66.360 18.848 1.00 0.17 N ATOM 278 CA PHE A 17
6.527 66.870 18.904 1.00 0.17 C ATOM 279 C PHE A 17 6.595 68.309
18.543 1.00 0.17 C ATOM 280 O PHE A 17 7.645 68.943 18.627 1.00
0.17 O ATOM 281 CB PHE A 17 5.886 66.867 20.300 1.00 0.17 C ATOM
282 CG PHE A 17 5.562 65.480 20.720 1.00 0.17 C ATOM 283 CD1 PHE A
17 4.468 64.838 20.192 1.00 0.17 C ATOM 284 CD2 PHE A 17 6.337
64.840 21.657 1.00 0.17 C ATOM 285 CE1 PHE A 17 4.154 63.561 20.585
1.00 0.17 C ATOM 286 CE2 PHE A 17 6.027 63.563 22.057 1.00 0.17 C
ATOM 287 CZ PHE A 17 4.935 62.927 21.518 1.00 0.17 C ATOM 288 H PHE
A 17 8.468 66.690 19.582 1.00 0.00 H ATOM 289 HA PHE A 17 5.913
66.277 18.229 1.00 0.00 H ATOM 290 1HB PHE A 17 4.946 67.418 20.184
1.00 0.00 H ATOM 291 2HB PHE A 17 6.495 67.400 21.041 1.00 0.00 H
ATOM 292 HD1 PHE A 17 3.883 65.351 19.440 1.00 0.00 H ATOM 293 HD2
PHE A 17 7.205 65.348 22.059 1.00 0.00 H ATOM 294 HE1 PHE A 17
3.235 63.140 20.300 1.00 0.00 H ATOM 295 HE2 PHE A 17 6.677 63.097
22.778 1.00 0.00 H ATOM 296 HZ PHE A 17 4.352 62.236 22.047 1.00
0.00 H ATOM 297 N LYS A 18 5.446 68.858 18.119 1.00 0.22 N ATOM 298
CA LYS A 18 5.403 70.243 17.781 1.00 0.22 C ATOM 299 C LYS A 18
5.558 70.999 19.056 1.00 0.22 C ATOM 300 O LYS A 18 5.134 70.546
20.119 1.00 0.22 O ATOM 301
CB LYS A 18 4.077 70.663 17.126 1.00 0.22 C ATOM 302 CG LYS A 18
2.859 70.405 18.012 1.00 0.22 C ATOM 303 CD LYS A 18 1.586 71.086
17.511 1.00 0.22 C ATOM 304 CE LYS A 18 0.375 70.870 18.418 1.00
0.22 C ATOM 305 NZ LYS A 18 -0.743 71.728 17.967 1.00 0.22 N1+ ATOM
306 H LYS A 18 4.641 68.278 17.925 1.00 0.00 H ATOM 307 HA LYS A 18
6.267 70.377 17.128 1.00 0.00 H ATOM 308 1HB LYS A 18 3.964 70.148
16.156 1.00 0.00 H ATOM 309 2HB LYS A 18 4.150 71.742 16.902 1.00
0.00 H ATOM 310 1HG LYS A 18 3.038 70.808 19.019 1.00 0.00 H ATOM
311 2HG LYS A 18 2.689 69.320 18.128 1.00 0.00 H ATOM 312 1HD LYS A
18 1.354 70.729 16.492 1.00 0.00 H ATOM 313 2HD LYS A 18 1.792
72.168 17.428 1.00 0.00 H ATOM 314 1HE LYS A 18 0.596 71.147 19.461
1.00 0.00 H ATOM 315 2HE LYS A 18 0.024 69.828 18.411 1.00 0.00 H
ATOM 316 1HZ LYS A 18 -1.576 71.594 18.528 1.00 0.00 H ATOM 317 2HZ
LYS A 18 -0.522 72.713 18.013 1.00 0.00 H ATOM 318 3HZ LYS A 18
-1.016 71.517 17.014 1.00 0.00 H ATOM 319 N GLY A 19 6.207 72.174
18.978 1.00 0.21 N ATOM 320 CA GLY A 19 6.383 72.980 20.146 1.00
0.21 C ATOM 321 C GLY A 19 7.708 72.652 20.746 1.00 0.21 C ATOM 322
O GLY A 19 8.192 73.365 21.623 1.00 0.21 O ATOM 323 H GLY A 19
6.494 72.539 18.071 1.00 0.00 H ATOM 324 1HA GLY A 19 5.676 72.621
20.917 1.00 0.00 H ATOM 325 2HA GLY A 19 6.080 74.028 20.096 1.00
0.00 H ATOM 326 N GLU A 20 8.338 71.560 20.281 1.00 0.23 N ATOM 327
CA GLU A 20 9.610 71.201 20.830 1.00 0.23 C ATOM 328 C GLU A 20
10.642 72.074 20.202 1.00 0.23 C ATOM 329 O GLU A 20 10.428 72.635
19.128 1.00 0.23 O ATOM 330 CB GLU A 20 10.002 69.736 20.574 1.00
0.23 C ATOM 331 CG GLU A 20 9.106 68.753 21.327 1.00 0.23 C ATOM
332 CD GLU A 20 9.228 69.092 22.806 1.00 0.23 C ATOM 333 OE1 GLU A
20 10.378 69.332 23.263 1.00 0.23 O ATOM 334 OE2 GLU A 20 8.174
69.131 23.495 1.00 0.23 O1- ATOM 335 H GLU A 20 7.903 70.908 19.641
1.00 0.00 H ATOM 336 HA GLU A 20 9.596 71.403 21.915 1.00 0.00 H
ATOM 337 1HB GLU A 20 11.054 69.593 20.883 1.00 0.00 H ATOM 338 2HB
GLU A 20 9.998 69.547 19.493 1.00 0.00 H ATOM 339 1HG GLU A 20
9.443 67.718 21.165 1.00 0.00 H ATOM 340 2HG GLU A 20 8.053 68.826
21.031 1.00 0.00 H ATOM 341 N ASN A 21 11.794 72.224 20.879 1.00
0.16 N ATOM 342 CA ASN A 21 12.833 73.051 20.346 1.00 0.16 C ATOM
343 C ASN A 21 13.814 72.151 19.677 1.00 0.16 C ATOM 344 O ASN A 21
14.134 71.074 20.179 1.00 0.16 O ATOM 345 CB ASN A 21 13.589 73.859
21.415 1.00 0.16 C ATOM 346 CG ASN A 21 12.613 74.885 21.970 1.00
0.16 C ATOM 347 OD1 ASN A 21 11.595 75.174 21.347 1.00 0.16 O ATOM
348 ND2 ASN A 21 12.923 75.448 23.168 1.00 0.16 N ATOM 349 H ASN A
21 12.004 71.689 21.705 1.00 0.00 H ATOM 350 HA ASN A 21 12.376
73.724 19.624 1.00 0.00 H ATOM 351 1HB ASN A 21 14.424 74.395
20.932 1.00 0.00 H ATOM 352 2HB ASN A 21 13.999 73.200 22.196 1.00
0.00 H ATOM 353 1HD2 ASN A 21 13.738 75.183 23.688 1.00 0.00 H ATOM
354 2HD2 ASN A 21 12.260 76.106 23.540 1.00 0.00 H ATOM 355 N VAL A
22 14.289 72.567 18.490 1.00 0.07 N ATOM 356 CA VAL A 22 15.243
71.773 17.780 1.00 0.07 C ATOM 357 C VAL A 22 16.438 72.632 17.559
1.00 0.07 C ATOM 358 O VAL A 22 16.312 73.813 17.236 1.00 0.07 O
ATOM 359 CB VAL A 22 14.753 71.331 16.431 1.00 0.07 C ATOM 360 CG1
VAL A 22 15.891 70.592 15.710 1.00 0.07 C ATOM 361 CG2 VAL A 22
13.481 70.487 16.626 1.00 0.07 C ATOM 362 H VAL A 22 14.067 73.488
18.125 1.00 0.00 H ATOM 363 HA VAL A 22 15.511 70.880 18.368 1.00
0.00 H ATOM 364 HB VAL A 22 14.492 72.177 15.798 1.00 0.00 H ATOM
365 1HG1 VAL A 22 15.529 70.095 14.795 1.00 0.00 H ATOM 366 2HG1
VAL A 22 16.697 71.275 15.398 1.00 0.00 H ATOM 367 3HG1 VAL A 22
16.314 69.825 16.375 1.00 0.00 H ATOM 368 1HG2 VAL A 22 13.124
70.080 15.667 1.00 0.00 H ATOM 369 2HG2 VAL A 22 13.699 69.636
17.292 1.00 0.00 H ATOM 370 3HG2 VAL A 22 12.657 71.073 17.064 1.00
0.00 H ATOM 371 N THR A 23 17.641 72.066 17.762 1.00 0.06 N ATOM
372 CA THR A 23 18.823 72.838 17.530 1.00 0.06 C ATOM 373 C THR A
23 19.615 72.126 16.486 1.00 0.06 C ATOM 374 O THR A 23 19.909
70.939 16.612 1.00 0.06 O ATOM 375 CB THR A 23 19.704 72.975 18.737
1.00 0.06 C ATOM 376 OG1 THR A 23 18.992 73.612 19.787 1.00 0.06 O
ATOM 377 CG2 THR A 23 20.936 73.813 18.353 1.00 0.06 C ATOM 378 H
THR A 23 17.775 71.115 18.098 1.00 0.00 H ATOM 379 HA THR A 23
18.556 73.850 17.211 1.00 0.00 H ATOM 380 HB THR A 23 20.031 71.986
19.091 1.00 0.00 H ATOM 381 HG1 THR A 23 18.059 73.402 19.624 1.00
0.00 H ATOM 382 1HG2 THR A 23 21.551 74.025 19.243 1.00 0.00 H ATOM
383 2HG2 THR A 23 21.585 73.297 17.628 1.00 0.00 H ATOM 384 3HG2
THR A 23 20.634 74.784 17.926 1.00 0.00 H ATOM 385 N LEU A 24
19.967 72.846 15.407 1.00 0.06 N ATOM 386 CA LEU A 24 20.752 72.253
14.368 1.00 0.06 C ATOM 387 C LEU A 24 22.058 72.966 14.393 1.00
0.06 C ATOM 388 O LEU A 24 22.104 74.195 14.388 1.00 0.06 O ATOM
389 CB LEU A 24 20.163 72.461 12.965 1.00 0.06 C ATOM 390 CG LEU A
24 18.783 71.804 12.774 1.00 0.06 C ATOM 391 CD1 LEU A 24 18.246
72.039 11.352 1.00 0.06 C ATOM 392 CD2 LEU A 24 18.814 70.318
13.167 1.00 0.06 C ATOM 393 H LEU A 24 19.688 73.815 15.281 1.00
0.00 H ATOM 394 HA LEU A 24 20.869 71.185 14.552 1.00 0.00 H ATOM
395 1HB LEU A 24 20.876 72.019 12.246 1.00 0.00 H ATOM 396 2HB LEU
A 24 20.105 73.537 12.729 1.00 0.00 H ATOM 397 HG LEU A 24 18.071
72.302 13.461 1.00 0.00 H ATOM 398 1HD1 LEU A 24 17.231 71.624
11.245 1.00 0.00 H ATOM 399 2HD1 LEU A 24 18.193 73.115 11.117 1.00
0.00 H ATOM 400 3HD1 LEU A 24 18.893 71.560 10.600 1.00 0.00 H ATOM
401 1HD2 LEU A 24 17.820 69.888 12.973 1.00 0.00 H ATOM 402 2HD2
LEU A 24 19.551 69.756 12.571 1.00 0.00 H ATOM 403 3HD2 LEU A 24
19.059 70.199 14.225 1.00 0.00 H ATOM 404 N THR A 25 23.167 72.207
14.441 1.00 0.28 N ATOM 405 CA THR A 25 24.439 72.857 14.453 1.00
0.28 C ATOM 406 C THR A 25 25.210 72.309 13.308 1.00 0.28 C ATOM
407 O THR A 25 25.220 71.106 13.059 1.00 0.28 O ATOM 408 CB THR A
25 25.235 72.590 15.697 1.00 0.28 C ATOM 409 OG1 THR A 25 24.523
73.038 16.841 1.00 0.28 O ATOM 410 CG2 THR A 25 26.580 73.327
15.588 1.00 0.28 C ATOM 411 H THR A 25 23.130 71.194 14.477 1.00
0.00 H ATOM 412 HA THR A 25 24.322 73.946 14.351 1.00 0.00 H ATOM
413 HB THR A 25 25.413 71.521 15.855 1.00 0.00 H ATOM 414 HG1 THR A
25 24.344 73.978 16.692 1.00 0.00 H ATOM 415 1HG2 THR A 25 27.114
73.289 16.552 1.00 0.00 H ATOM 416 2HG2 THR A 25 27.249 72.875
14.839 1.00 0.00 H ATOM 417 3HG2 THR A 25 26.439 74.392 15.338 1.00
0.00 H ATOM 418 N CYS A 26 25.878 73.197 12.565 1.00 0.52 N ATOM
419 CA CYS A 26 26.616 72.723 11.446 1.00 0.52 C ATOM 420 C CYS A
26 28.050 72.983 11.751 1.00 0.52 C ATOM 421 O CYS A 26 28.460
74.132 11.908 1.00 0.52 O ATOM 422 CB CYS A 26 26.230 73.510 10.198
1.00 0.52 C ATOM 423 SG CYS A 26 27.098 72.999 8.709 1.00 0.52 S
ATOM 424 H CYS A 26 25.870 74.196 12.727 1.00 0.00 H ATOM 425 HA
CYS A 26 26.399 71.671 11.235 1.00 0.00 H ATOM 426 1HB CYS A 26
26.355 74.595 10.346 1.00 0.00 H ATOM 427 2HB CYS A 26 25.173
73.319 10.007 1.00 0.00 H ATOM 428 N ASN A 27 28.853 71.907 11.836
1.00 0.35 N ATOM 429 CA ASN A 27 30.232 72.073 12.176 1.00 0.35 C
ATOM 430 C ASN A 27 31.043 71.766 10.964 1.00 0.35 C ATOM 431 O ASN
A 27 30.620 71.010 10.092 1.00 0.35 O ATOM 432 CB ASN A 27 30.713
71.117 13.280 1.00 0.35 C ATOM 433 CG ASN A 27 30.594 69.697 12.743
1.00 0.35 C ATOM 434 OD1 ASN A 27 29.551 69.298 12.228 1.00 0.35 O
ATOM 435 ND2 ASN A 27 31.698 68.912 12.855 1.00 0.35 N ATOM 436 H
ASN A 27 28.542 70.946 11.685 1.00 0.00 H ATOM 437 HA ASN A 27
30.415 73.099 12.532 1.00 0.00 H ATOM 438 1HB ASN A 27 30.081
71.201 14.180 1.00 0.00 H ATOM 439 2HB ASN A 27 31.746 71.384
13.557 1.00 0.00 H ATOM 440 1HD2 ASN A 27 32.530 69.230 13.317 1.00
0.00 H ATOM 441 2HD2 ASN A 27 31.597 67.953 12.575 1.00 0.00 H ATOM
442 N GLY A 28 32.237 72.381 10.876 1.00 0.15 N ATOM 443 CA GLY A
28 33.101 72.141 9.762 1.00 0.15 C ATOM 444 C GLY A 28 33.969
73.345 9.623 1.00 0.15 C ATOM 445 O GLY A 28 33.839 74.305 10.382
1.00 0.15 O ATOM 446 H GLY A 28 32.528 73.118 11.502 1.00 0.00 H
ATOM 447 1HA GLY A 28 32.514 72.014 8.837 1.00 0.00 H ATOM 448 2HA
GLY A 28 33.710 71.234 9.918 1.00 0.00 H ATOM 449 N ASN A 29 34.882
73.329 8.633 1.00 0.16 N ATOM 450 CA ASN A 29 35.730 74.467 8.454
1.00 0.16 C ATOM 451 C ASN A 29 34.852 75.590 8.021 1.00 0.16 C
ATOM 452 O ASN A 29 33.866 75.388 7.315 1.00 0.16 O ATOM 453 CB ASN
A 29 36.820 74.286 7.382 1.00 0.16 C ATOM 454 CG ASN A 29 37.876
73.331 7.919 1.00 0.16 C ATOM 455 OD1 ASN A 29 37.878 72.973 9.096
1.00 0.16 O ATOM 456 ND2 ASN A 29 38.816 72.917 7.029 1.00 0.16 N
ATOM 457 H ASN A 29 35.005 72.548 8.013 1.00 0.00 H ATOM 458 HA ASN
A 29 36.207 74.723 9.419 1.00 0.00 H ATOM 459 1HB ASN A 29 37.363
75.225 7.240 1.00 0.00 H ATOM 460 2HB ASN A 29 36.417 73.884 6.449
1.00 0.00 H ATOM 461 1HD2 ASN A 29 38.833 73.235 6.078 1.00 0.00 H
ATOM 462 2HD2 ASN A 29 39.532 72.304 7.380 1.00 0.00 H ATOM 463 N
ASN A 30 35.187 76.815 8.463 1.00 0.16 N ATOM 464 CA ASN A 30
34.377 77.945 8.127 1.00 0.16 C ATOM 465 C ASN A 30 35.268 79.043
7.645 1.00 0.16 C ATOM 466 O ASN A 30 36.420 79.153 8.060 1.00 0.16
O ATOM 467 CB ASN A 30 33.609 78.491 9.339 1.00 0.16 C ATOM 468 CG
ASN A 30 32.795 79.688 8.886 1.00 0.16 C ATOM 469 OD1 ASN A 30
32.210 79.707 7.805 1.00 0.16 O ATOM 470 ND2 ASN A 30 32.781 80.740
9.746 1.00 0.16 N ATOM 471 H ASN A 30 36.004 77.014 9.015 1.00 0.00
H ATOM 472 HA ASN A 30 33.660 77.670 7.338 1.00 0.00 H ATOM 473 1HB
ASN A 30 34.308 78.750 10.151 1.00 0.00 H ATOM 474 2HB ASN A 30
32.904 77.733 9.720 1.00 0.00 H ATOM 475 1HD2 ASN A 30 33.250
80.708 10.630 1.00 0.00 H ATOM 476 2HD2 ASN A 30 32.054 81.435
9.600 1.00 0.00 H ATOM 477 N PHE A 31 34.745 79.879 6.724 1.00 0.12
N ATOM 478 CA PHE A 31 35.486 81.003 6.236 1.00 0.12 C ATOM 479 C
PHE A 31 35.228 82.101 7.212 1.00 0.12 C ATOM 480 O PHE A 31 34.243
82.061 7.945 1.00 0.12 O ATOM 481 CB PHE A 31 35.024 81.481 4.850
1.00 0.12 C ATOM 482 CG PHE A 31 35.870 82.641 4.458 1.00 0.12 C
ATOM 483 CD1 PHE A 31 37.137 82.444 3.958 1.00 0.12 C ATOM 484 CD2
PHE A 31 35.395 83.926 4.581 1.00 0.12 C ATOM 485 CE1 PHE A 31
37.919 83.513 3.589 1.00 0.12 C ATOM 486 CE2 PHE A 31 36.173 84.999
4.215 1.00 0.12 C ATOM 487 CZ PHE A 31 37.439 84.793 3.720 1.00
0.12 C ATOM 488 H PHE A 31 33.732 79.978 6.684 1.00 0.00 H ATOM 489
HA PHE A 31 36.560 80.758 6.226 1.00 0.00 H ATOM 490 1HB PHE A 31
33.955 81.746 4.883 1.00 0.00 H ATOM 491 2HB PHE A 31 35.127 80.664
4.121 1.00 0.00 H ATOM 492 HD1 PHE A 31 37.521 81.438 3.830 1.00
0.00 H ATOM 493 HD2 PHE A 31 34.399 84.066 4.975 1.00 0.00 H ATOM
494 HE1 PHE A 31 38.916 83.346 3.188 1.00 0.00 H ATOM 495 HE2 PHE A
31 35.783 86.009 4.316 1.00 0.00 H ATOM 496 HZ PHE A 31 38.053
85.642 3.428 1.00 0.00 H ATOM 497 N PHE A 32 36.111 83.113 7.268
1.00 0.11 N ATOM 498 CA PHE A 32 35.851 84.138 8.229 1.00 0.11 C
ATOM 499 C PHE A 32 34.911 85.104 7.598 1.00 0.11 C ATOM 500 O PHE
A 32 35.322 86.086 6.982 1.00 0.11 O ATOM 501 CB PHE A 32 37.114
84.895 8.670 1.00 0.11 C ATOM 502 CG PHE A 32 37.971 83.875 9.336
1.00 0.11 C ATOM 503 CD1 PHE A 32 38.800 83.076 8.583 1.00 0.11 C
ATOM 504 CD2 PHE A 32 37.941 83.706 10.700 1.00 0.11 C ATOM 505 CE1
PHE A 32 39.597 82.127 9.178 1.00 0.11 C ATOM 506 CE2 PHE A 32
38.735 82.758 11.300 1.00 0.11 C ATOM 507 CZ PHE A 32 39.564 81.967
10.542 1.00 0.11 C ATOM 508 H PHE A 32 36.835 83.274 6.588 1.00
0.00 H ATOM 509 HA PHE A 32 35.409 83.699 9.143 1.00 0.00 H ATOM
510 1HB PHE A 32 36.811 85.700 9.358 1.00 0.00 H ATOM 511 2HB PHE A
32 37.630 85.368 7.820 1.00 0.00 H ATOM 512 HD1 PHE A 32 38.864
83.214 7.507 1.00 0.00 H ATOM 513 HD2 PHE A 32 37.287 84.326 11.307
1.00 0.00 H ATOM 514 HE1 PHE A 32 40.252 81.506 8.572 1.00 0.00 H
ATOM 515 HE2 PHE A 32 38.705 82.632 12.380 1.00 0.00 H ATOM 516 HZ
PHE A 32 40.190 81.217 11.019 1.00 0.00 H ATOM 517 N GLU A 33
33.600 84.832 7.738 1.00 0.10 N ATOM 518 CA GLU A 33 32.616 85.702
7.171 1.00 0.10 C ATOM 519 C GLU A 33 31.455 85.739 8.108 1.00 0.10
C ATOM 520 O GLU A 33 31.273 84.837 8.926 1.00 0.10 O ATOM 521 CB
GLU A 33 32.084 85.228 5.809 1.00 0.10 C ATOM 522 CG GLU A 33
31.401 83.860 5.863 1.00 0.10 C ATOM 523 CD GLU A 33 30.934 83.526
4.456 1.00 0.10 C ATOM 524 OE1 GLU A 33 30.393 84.442 3.782 1.00
0.10 O ATOM 525 OE2 GLU A 33 31.113 82.351 4.035 1.00 0.10 O1- ATOM
526 H GLU A 33 33.268 83.963 8.132 1.00 0.00 H ATOM 527 HA GLU A 33
33.037 86.717 7.082 1.00 0.00 H ATOM 528 1HB GLU A 33 32.872 85.275
5.047 1.00 0.00 H ATOM 529 2HB GLU A 33 31.344 85.987 5.494 1.00
0.00 H ATOM 530 1HG GLU A 33 30.550 83.937 6.545 1.00 0.00 H ATOM
531 2HG GLU A 33 32.063 83.066 6.242 1.00 0.00 H ATOM 532 N VAL A
34 30.644 86.808 8.020 1.00 0.09 N ATOM 533 CA VAL A 34 29.511
86.925 8.884 1.00 0.09 C ATOM 534 C VAL A 34 28.559 85.818 8.570
1.00 0.09 C ATOM 535 O VAL A 34 28.077 85.132 9.470 1.00 0.09 O
ATOM 536 CB VAL A 34 28.792 88.229 8.712 1.00 0.09 C ATOM 537 CG1
VAL A 34 27.594 88.260 9.674 1.00 0.09 C ATOM 538 CG2 VAL A 34
29.797 89.369 8.948 1.00 0.09 C ATOM 539 H VAL A 34 30.817 87.554
7.369 1.00 0.00 H ATOM 540 HA VAL A 34 29.835 86.811 9.932 1.00
0.00 H ATOM 541 HB VAL A 34 28.403 88.320 7.681 1.00 0.00 H ATOM
542 1HG1 VAL A 34 27.078 89.234 9.646 1.00 0.00 H ATOM 543 2HG1 VAL
A 34 26.840 87.496 9.421 1.00 0.00 H ATOM 544 3HG1 VAL A 34 27.913
88.090 10.716 1.00 0.00 H ATOM 545 1HG2 VAL A 34 29.295 90.352
8.942 1.00 0.00 H ATOM 546 2HG2 VAL A 34 30.288 89.266 9.931 1.00
0.00 H ATOM 547 3HG2 VAL A 34 30.583 89.418 8.177 1.00 0.00 H ATOM
548 N SER A 35 28.277 85.587 7.274 1.00 0.11 N ATOM 549 CA SER A 35
27.364 84.531 6.942 1.00 0.11 C ATOM 550 C SER A 35 28.183 83.307
6.696 1.00 0.11 C ATOM 551 O SER A 35 28.493 82.953 5.559 1.00 0.11
O ATOM 552 CB SER A 35 26.512 84.826 5.689 1.00 0.11 C ATOM 553 OG
SER A 35 27.339 85.023 4.552 1.00 0.11 O ATOM 554 H SER A 35 28.711
86.062 6.500 1.00 0.00 H ATOM 555 HA SER A 35 26.653 84.371 7.771
1.00 0.00 H ATOM 556 1HB SER A 35 25.922 85.742 5.827 1.00 0.00 H
ATOM 557 2HB SER A 35 25.812 83.985 5.528 1.00 0.00 H ATOM 558 HG
SER A 35 27.975 84.275 4.528 1.00 0.00 H ATOM 559 N SER A 36 28.548
82.623 7.794 1.00 0.27 N ATOM 560 CA SER A 36 29.398 81.472 7.742
1.00 0.27 C ATOM 561 C SER A 36 28.707 80.338 7.057 1.00 0.27 C
ATOM 562 O SER A 36 29.282 79.676 6.194 1.00 0.27 O ATOM 563 CB SER
A 36 29.776 80.977 9.147 1.00 0.27 C ATOM 564 OG SER A 36 30.410
82.020 9.871 1.00 0.27 O ATOM 565 H SER A 36 28.273 82.996 8.696
1.00 0.00 H ATOM 566 HA SER A 36 30.311 81.701 7.172 1.00 0.00 H
ATOM 567 1HB SER A 36 30.374 80.065 9.130 1.00 0.00 H ATOM 568 2HB
SER A 36 28.855 80.708 9.694 1.00 0.00 H ATOM 569 HG SER A 36
30.299 82.846 9.362 1.00 0.00 H ATOM 570 N THR A 37 27.431 80.089
7.399 1.00 0.48 N ATOM 571 CA THR A 37 26.842 78.902 6.858 1.00
0.48 C ATOM 572 C THR A 37 25.567 79.191 6.148 1.00 0.48 C ATOM 573
O THR A 37 24.911 80.206 6.377 1.00 0.48 O ATOM 574 CB THR A 37
26.522 77.882 7.901 1.00 0.48 C ATOM 575 OG1 THR A 37 25.965 76.737
7.283 1.00 0.48 O ATOM 576 CG2 THR A 37 25.515 78.485 8.896 1.00
0.48 C ATOM 577 H THR A 37 26.845 80.714 7.922 1.00 0.00 H ATOM 578
HA THR A 37 27.513 78.421 6.132 1.00 0.00 H ATOM 579 HB THR A 37
27.418 77.638 8.460 1.00 0.00 H ATOM 580 HG1 THR A 37 25.715 76.122
7.988 1.00 0.00 H ATOM 581 1HG2 THR A 37 25.307 77.711 9.648 1.00
0.00 H ATOM 582 2HG2 THR A 37 25.923 79.370 9.399 1.00 0.00 H ATOM
583 3HG2 THR A 37 24.557 78.741 8.418 1.00 0.00 H ATOM 584 N LYS A
38 25.205 78.268 5.235 1.00 0.41 N ATOM 585 CA LYS A 38 23.972
78.360 4.517 1.00 0.41 C ATOM 586 C LYS A 38 23.171 77.183 4.969
1.00 0.41 C ATOM 587 O LYS A 38 23.687 76.068 5.054 1.00 0.41 O
ATOM 588 CB LYS A 38 24.131 78.210 2.995 1.00 0.41 C ATOM 589 CG
LYS A 38 25.186 79.135 2.385 1.00 0.41 C ATOM 590 CD LYS A 38
26.617 78.728 2.751 1.00 0.41 C ATOM 591 CE LYS A 38 27.700 79.493
1.986 1.00 0.41 C ATOM 592 NZ LYS A 38 29.037 78.966 2.348 1.00
0.41 N1+ ATOM 593 H LYS A 38 25.629 77.348 5.315 1.00 0.00 H ATOM
594 HA LYS A 38 23.477 79.318 4.738 1.00 0.00 H ATOM 595 1HB LYS A
38 23.141 78.390 2.541 1.00 0.00 H ATOM 596 2HB LYS A 38 24.408
77.173 2.761 1.00 0.00 H ATOM 597 1HG LYS A 38 24.996 80.183 2.681
1.00 0.00 H ATOM 598 2HG LYS A 38 25.082 79.106 1.285 1.00 0.00
H
ATOM 599 1HD LYS A 38 26.726 77.658 2.649 1.00 0.00 H ATOM 600 2HD
LYS A 38 26.849 78.975 3.795 1.00 0.00 H ATOM 601 1HE LYS A 38
27.684 80.565 2.244 1.00 0.00 H ATOM 602 2HE LYS A 38 27.598 79.398
0.893 1.00 0.00 H ATOM 603 1HZ LYS A 38 29.782 79.444 1.855 1.00
0.00 H ATOM 604 2HZ LYS A 38 29.227 79.092 3.336 1.00 0.00 H ATOM
605 3HZ LYS A 38 29.137 77.982 2.132 1.00 0.00 H ATOM 606 N TRP A
39 21.884 77.401 5.297 1.00 0.18 N ATOM 607 CA TRP A 39 21.073
76.294 5.707 1.00 0.18 C ATOM 608 C TRP A 39 20.040 76.079 4.659
1.00 0.18 C ATOM 609 O TRP A 39 19.565 77.025 4.034 1.00 0.18 O
ATOM 610 CB TRP A 39 20.331 76.490 7.044 1.00 0.18 C ATOM 611 CG
TRP A 39 21.211 76.379 8.268 1.00 0.18 C ATOM 612 CD1 TRP A 39
21.745 77.350 9.062 1.00 0.18 C ATOM 613 CD2 TRP A 39 21.658 75.123
8.802 1.00 0.18 C ATOM 614 NE1 TRP A 39 22.498 76.776 10.062 1.00
0.18 N ATOM 615 CE2 TRP A 39 22.453 75.405 9.912 1.00 0.18 C ATOM
616 CE3 TRP A 39 21.425 73.840 8.397 1.00 0.18 C ATOM 617 CZ2 TRP A
39 23.031 74.401 10.636 1.00 0.18 C ATOM 618 CZ3 TRP A 39 22.006
72.830 9.130 1.00 0.18 C ATOM 619 CH2 TRP A 39 22.793 73.105 10.228
1.00 0.18 C ATOM 620 H TRP A 39 21.424 78.294 5.236 1.00 0.00 H
ATOM 621 HA TRP A 39 21.686 75.386 5.806 1.00 0.00 H ATOM 622 1HB
TRP A 39 19.541 75.720 7.109 1.00 0.00 H ATOM 623 2HB TRP A 39
19.802 77.454 7.048 1.00 0.00 H ATOM 624 HD1 TRP A 39 21.773 78.413
8.875 1.00 0.00 H ATOM 625 HE1 TRP A 39 23.073 77.294 10.699 1.00
0.00 H ATOM 626 HE3 TRP A 39 20.762 73.621 7.571 1.00 0.00 H ATOM
627 HZ2 TRP A 39 23.619 74.619 11.521 1.00 0.00 H ATOM 628 HZ3 TRP
A 39 21.828 71.796 8.843 1.00 0.00 H ATOM 629 HH2 TRP A 39 23.234
72.302 10.807 1.00 0.00 H ATOM 630 N PHE A 40 19.690 74.803 4.416
1.00 0.08 N ATOM 631 CA PHE A 40 18.688 74.538 3.434 1.00 0.08 C
ATOM 632 C PHE A 40 17.664 73.654 4.057 1.00 0.08 C ATOM 633 O PHE
A 40 17.990 72.739 4.811 1.00 0.08 O ATOM 634 CB PHE A 40 19.229
73.816 2.190 1.00 0.08 C ATOM 635 CG PHE A 40 20.153 74.766 1.514
1.00 0.08 C ATOM 636 CD1 PHE A 40 21.465 74.872 1.916 1.00 0.08 C
ATOM 637 CD2 PHE A 40 19.703 75.553 0.478 1.00 0.08 C ATOM 638 CE1
PHE A 40 22.315 75.752 1.291 1.00 0.08 C ATOM 639 CE2 PHE A 40
20.551 76.435 -0.150 1.00 0.08 C ATOM 640 CZ PHE A 40 21.860 76.534
0.257 1.00 0.08 C ATOM 641 H PHE A 40 20.105 74.013 4.892 1.00 0.00
H ATOM 642 HA PHE A 40 18.309 75.494 3.136 1.00 0.00 H ATOM 643 1HB
PHE A 40 18.376 73.555 1.549 1.00 0.00 H ATOM 644 2HB PHE A 40
19.730 72.882 2.471 1.00 0.00 H ATOM 645 HD1 PHE A 40 21.845 74.243
2.717 1.00 0.00 H ATOM 646 HD2 PHE A 40 18.681 75.450 0.130 1.00
0.00 H ATOM 647 HE1 PHE A 40 23.355 75.778 1.589 1.00 0.00 H ATOM
648 HE2 PHE A 40 20.213 76.986 -1.023 1.00 0.00 H ATOM 649 HZ PHE A
40 22.535 77.216 -0.253 1.00 0.00 H ATOM 650 N HIS A 41 16.383
73.945 3.777 1.00 0.10 N ATOM 651 CA HIS A 41 15.322 73.109 4.242
1.00 0.10 C ATOM 652 C HIS A 41 14.620 72.643 3.014 1.00 0.10 C
ATOM 653 O HIS A 41 14.100 73.447 2.242 1.00 0.10 O ATOM 654 CB HIS
A 41 14.287 73.836 5.109 1.00 0.10 C ATOM 655 CG HIS A 41 13.274
72.893 5.682 1.00 0.10 C ATOM 656 ND1 HIS A 41 12.236 73.278 6.499
1.00 0.10 N ATOM 657 CD2 HIS A 41 13.159 71.544 5.541 1.00 0.10 C
ATOM 658 CE1 HIS A 41 11.548 72.151 6.810 1.00 0.10 C ATOM 659 NE2
HIS A 41 12.071 71.072 6.253 1.00 0.10 N ATOM 660 H HIS A 41 16.131
74.767 3.233 1.00 0.00 H ATOM 661 HA HIS A 41 15.740 72.280 4.830
1.00 0.00 H ATOM 662 1HB HIS A 41 13.796 74.642 4.539 1.00 0.00 H
ATOM 663 2HB HIS A 41 14.822 74.338 5.936 1.00 0.00 H ATOM 664 HD2
HIS A 41 13.744 70.826 5.017 1.00 0.00 H ATOM 665 HE1 HIS A 41
10.614 72.196 7.348 1.00 0.00 H ATOM 666 HE2 HIS A 41 11.764 70.142
6.452 1.00 0.00 H ATOM 667 N ASN A 42 14.593 71.319 2.797 1.00 0.11
N ATOM 668 CA ASN A 42 13.967 70.801 1.622 1.00 0.11 C ATOM 669 C
ASN A 42 14.617 71.443 0.440 1.00 0.11 C ATOM 670 O ASN A 42 14.003
71.602 -0.614 1.00 0.11 O ATOM 671 CB ASN A 42 12.450 71.059 1.562
1.00 0.11 C ATOM 672 CG ASN A 42 11.781 70.123 2.558 1.00 0.11 C
ATOM 673 OD1 ASN A 42 12.427 69.246 3.129 1.00 0.11 O ATOM 674 ND2
ASN A 42 10.447 70.298 2.758 1.00 0.11 N ATOM 675 H ASN A 42 14.894
70.665 3.517 1.00 0.00 H ATOM 676 HA ASN A 42 14.186 69.722 1.529
1.00 0.00 H ATOM 677 1HB ASN A 42 12.064 70.773 0.568 1.00 0.00 H
ATOM 678 2HB ASN A 42 12.165 72.105 1.744 1.00 0.00 H ATOM 679 1HD2
ASN A 42 9.946 71.057 2.334 1.00 0.00 H ATOM 680 2HD2 ASN A 42
10.000 69.733 3.462 1.00 0.00 H ATOM 681 N GLY A 43 15.899 71.821
0.589 1.00 0.08 N ATOM 682 CA GLY A 43 16.624 72.378 -0.515 1.00
0.08 C ATOM 683 C GLY A 43 16.364 73.848 -0.611 1.00 0.08 C ATOM
684 O GLY A 43 16.830 74.497 -1.546 1.00 0.08 O ATOM 685 H GLY A 43
16.250 71.979 1.521 1.00 0.00 H ATOM 686 1HA GLY A 43 16.323 71.897
-1.458 1.00 0.00 H ATOM 687 2HA GLY A 43 17.706 72.230 -0.374 1.00
0.00 H ATOM 688 N SER A 44 15.617 74.428 0.346 1.00 0.15 N ATOM 689
CA SER A 44 15.375 75.838 0.255 1.00 0.15 C ATOM 690 C SER A 44
16.345 76.510 1.167 1.00 0.15 C ATOM 691 O SER A 44 16.513 76.111
2.317 1.00 0.15 O ATOM 692 CB SER A 44 13.964 76.262 0.694 1.00
0.15 C ATOM 693 OG SER A 44 13.788 76.006 2.080 1.00 0.15 O ATOM
694 H SER A 44 15.032 73.916 0.998 1.00 0.00 H ATOM 695 HA SER A 44
15.484 76.176 -0.789 1.00 0.00 H ATOM 696 1HB SER A 44 13.195
75.690 0.158 1.00 0.00 H ATOM 697 2HB SER A 44 13.813 77.334 0.471
1.00 0.00 H ATOM 698 HG SER A 44 14.352 76.634 2.559 1.00 0.00 H
ATOM 699 N LEU A 45 17.025 77.556 0.666 1.00 0.35 N ATOM 700 CA LEU
A 45 17.997 78.240 1.465 1.00 0.35 C ATOM 701 C LEU A 45 17.255
79.014 2.504 1.00 0.35 C ATOM 702 O LEU A 45 16.195 79.578 2.241
1.00 0.35 O ATOM 703 CB LEU A 45 18.886 79.190 0.622 1.00 0.35 C
ATOM 704 CG LEU A 45 20.000 79.986 1.345 1.00 0.35 C ATOM 705 CD1
LEU A 45 20.847 80.767 0.328 1.00 0.35 C ATOM 706 CD2 LEU A 45
19.465 80.938 2.433 1.00 0.35 C ATOM 707 H LEU A 45 16.859 77.916
-0.258 1.00 0.00 H ATOM 708 HA LEU A 45 18.652 77.484 1.916 1.00
0.00 H ATOM 709 1HB LEU A 45 18.219 79.931 0.143 1.00 0.00 H ATOM
710 2HB LEU A 45 19.327 78.630 -0.212 1.00 0.00 H ATOM 711 HG LEU A
45 20.665 79.253 1.840 1.00 0.00 H ATOM 712 1HD1 LEU A 45 21.676
81.302 0.821 1.00 0.00 H ATOM 713 2HD1 LEU A 45 21.291 80.099
-0.428 1.00 0.00 H ATOM 714 3HD1 LEU A 45 20.234 81.514 -0.203 1.00
0.00 H ATOM 715 1HD2 LEU A 45 19.719 81.980 2.158 1.00 0.00 H ATOM
716 2HD2 LEU A 45 18.389 81.005 2.576 1.00 0.00 H ATOM 717 3HD2 LEU
A 45 20.074 80.759 3.311 1.00 0.00 H ATOM 718 N SER A 46 17.808
79.040 3.734 1.00 0.48 N ATOM 719 CA SER A 46 17.218 79.785 4.809
1.00 0.48 C ATOM 720 C SER A 46 18.124 80.941 5.078 1.00 0.48 C
ATOM 721 O SER A 46 19.320 80.771 5.301 1.00 0.48 O ATOM 722 CB SER
A 46 17.159 79.037 6.154 1.00 0.48 C ATOM 723 OG SER A 46 16.268
77.937 6.093 1.00 0.48 O ATOM 724 H SER A 46 18.589 78.436 3.972
1.00 0.00 H ATOM 725 HA SER A 46 16.185 80.070 4.554 1.00 0.00 H
ATOM 726 1HB SER A 46 16.623 79.786 6.740 1.00 0.00 H ATOM 727 2HB
SER A 46 18.133 78.779 6.591 1.00 0.00 H ATOM 728 HG SER A 46
16.014 77.771 7.023 1.00 0.00 H ATOM 729 N GLU A 47 17.561 82.158
5.029 1.00 0.44 N ATOM 730 CA GLU A 47 18.248 83.383 5.316 1.00
0.44 C ATOM 731 C GLU A 47 18.453 83.486 6.797 1.00 0.44 C ATOM 732
O GLU A 47 19.343 84.188 7.271 1.00 0.44 O ATOM 733 CB GLU A 47
17.440 84.622 4.906 1.00 0.44 C ATOM 734 CG GLU A 47 16.115 84.730
5.662 1.00 0.44 C ATOM 735 CD GLU A 47 15.396 85.988 5.203 1.00
0.44 C ATOM 736 OE1 GLU A 47 15.858 86.606 4.206 1.00 0.44 O ATOM
737 OE2 GLU A 47 14.373 86.349 5.844 1.00 0.44 O1- ATOM 738 H GLU A
47 16.607 82.284 4.724 1.00 0.00 H ATOM 739 HA GLU A 47 19.239
83.381 4.833 1.00 0.00 H ATOM 740 1HB GLU A 47 17.273 84.585 3.815
1.00 0.00 H ATOM 741 2HB GLU A 47 18.068 85.508 5.110 1.00 0.00 H
ATOM 742 1HG GLU A 47 16.248 84.814 6.752 1.00 0.00 H ATOM 743 2HG
GLU A 47 15.450 83.868 5.495 1.00 0.00 H ATOM 744 N GLU A 48 17.608
82.766 7.551 1.00 0.45 N ATOM 745 CA GLU A 48 17.419 82.881 8.969
1.00 0.45 C ATOM 746 C GLU A 48 18.648 82.740 9.823 1.00 0.45 C
ATOM 747 O GLU A 48 18.857 83.579 10.697 1.00 0.45 O ATOM 748 CB
GLU A 48 16.414 81.833 9.468 1.00 0.45 C ATOM 749 CG GLU A 48
16.862 80.403 9.154 1.00 0.45 C ATOM 750 CD GLU A 48 15.749 79.447
9.560 1.00 0.45 C ATOM 751 OE1 GLU A 48 14.717 79.928 10.099 1.00
0.45 O ATOM 752 OE2 GLU A 48 15.917 78.219 9.333 1.00 0.45 O1- ATOM
753 H GLU A 48 16.949 82.175 7.075 1.00 0.00 H ATOM 754 HA GLU A 48
17.016 83.885 9.188 1.00 0.00 H ATOM 755 1HB GLU A 48 15.437 82.052
8.999 1.00 0.00 H ATOM 756 2HB GLU A 48 16.290 81.972 10.557 1.00
0.00 H ATOM 757 1HG GLU A 48 17.655 80.150 9.869 1.00 0.00 H ATOM
758 2HG GLU A 48 17.413 80.258 8.238 1.00 0.00 H ATOM 759 N THR A
49 19.523 81.735 9.626 1.00 0.55 N ATOM 760 CA THR A 49 20.475
81.591 10.695 1.00 0.55 C ATOM 761 C THR A 49 21.869 81.303 10.218
1.00 0.55 C ATOM 762 O THR A 49 22.124 81.078 9.036 1.00 0.55 O
ATOM 763 CB THR A 49 20.062 80.467 11.603 1.00 0.55 C ATOM 764 OG1
THR A 49 20.882 80.388 12.757 1.00 0.55 O ATOM 765 CG2 THR A 49
20.139 79.164 10.795 1.00 0.55 C ATOM 766 H THR A 49 19.450 81.037
8.909 1.00 0.00 H ATOM 767 HA THR A 49 20.596 82.511 11.285 1.00
0.00 H ATOM 768 HB THR A 49 19.051 80.768 11.920 1.00 0.00 H ATOM
769 HG1 THR A 49 20.723 79.538 13.198 1.00 0.00 H ATOM 770 1HG2 THR
A 49 19.326 78.450 10.800 1.00 0.00 H ATOM 771 2HG2 THR A 49 20.226
79.357 9.715 1.00 0.00 H ATOM 772 3HG2 THR A 49 21.061 78.660
11.101 1.00 0.00 H ATOM 773 N ASN A 50 22.808 81.331 11.191 1.00
0.44 N ATOM 774 CA ASN A 50 24.216 81.101 11.036 1.00 0.44 C ATOM
775 C ASN A 50 24.526 79.690 11.431 1.00 0.44 C ATOM 776 O ASN A 50
23.788 78.756 11.124 1.00 0.44 O ATOM 777 CB ASN A 50 25.082 82.012
11.923 1.00 0.44 C ATOM 778 CG ASN A 50 24.987 83.430 11.383 1.00
0.44 C ATOM 779 OD1 ASN A 50 25.306 83.682 10.223 1.00 0.44 O ATOM
780 ND2 ASN A 50 24.536 84.383 12.243 1.00 0.44 N ATOM 781 H ASN A
50 22.433 81.246 12.132 1.00 0.00 H ATOM 782 HA ASN A 50 24.490
81.217 9.974 1.00 0.00 H ATOM 783 1HB ASN A 50 26.160 81.813 11.801
1.00 0.00 H ATOM 784 2HB ASN A 50 24.811 81.939 12.988 1.00 0.00 H
ATOM 785 1HD2 ASN A 50 24.226 84.171 13.172 1.00 0.00 H ATOM 786
2HD2 ASN A 50 24.430 85.308 11.862 1.00 0.00 H ATOM 787 N SER A 51
25.661 79.521 12.140 1.00 0.25 N ATOM 788 CA SER A 51 26.182 78.233
12.494 1.00 0.25 C ATOM 789 C SER A 51 25.171 77.448 13.267 1.00
0.25 C ATOM 790 O SER A 51 24.943 76.276 12.969 1.00 0.25 O ATOM
791 CB SER A 51 27.446 78.324 13.365 1.00 0.25 C ATOM 792 OG SER A
51 27.126 78.894 14.625 1.00 0.25 O ATOM 793 H SER A 51 26.206
80.301 12.462 1.00 0.00 H ATOM 794 HA SER A 51 26.417 77.665 11.581
1.00 0.00 H ATOM 795 1HB SER A 51 28.230 78.908 12.849 1.00 0.00 H
ATOM 796 2HB SER A 51 27.829 77.295 13.499 1.00 0.00 H ATOM 797 HG
SER A 51 27.896 78.769 15.200 1.00 0.00 H ATOM 798 N SER A 52
24.525 78.056 14.278 1.00 0.14 N ATOM 799 CA SER A 52 23.591 77.273
15.036 1.00 0.14 C ATOM 800 C SER A 52 22.214 77.760 14.740 1.00
0.14 C ATOM 801 O SER A 52 21.944 78.960 14.768 1.00 0.14 O ATOM
802 CB SER A 52 23.794 77.380 16.557 1.00 0.14 C ATOM 803 OG SER A
52 25.058 76.846 16.919 1.00 0.14 O ATOM 804 H SER A 52 24.837
78.941 14.640 1.00 0.00 H ATOM 805 HA SER A 52 23.703 76.203 14.814
1.00 0.00 H ATOM 806 1HB SER A 52 22.983 76.804 17.042 1.00 0.00 H
ATOM 807 2HB SER A 52 23.706 78.429 16.892 1.00 0.00 H ATOM 808 HG
SER A 52 25.161 76.977 17.872 1.00 0.00 H ATOM 809 N LEU A 53
21.296 76.826 14.422 1.00 0.09 N ATOM 810 CA LEU A 53 19.948 77.236
14.179 1.00 0.09 C ATOM 811 C LEU A 53 19.099 76.586 15.218 1.00
0.09 C ATOM 812 O LEU A 53 19.090 75.363 15.358 1.00 0.09 O ATOM
813 CB LEU A 53 19.400 76.833 12.798 1.00 0.09 C ATOM 814 CG LEU A
53 17.946 77.287 12.554 1.00 0.09 C ATOM 815 CD1 LEU A 53 17.822
78.817 12.594 1.00 0.09 C ATOM 816 CD2 LEU A 53 17.391 76.694
11.251 1.00 0.09 C ATOM 817 H LEU A 53 21.500 75.830 14.376 1.00
0.00 H ATOM 818 HA LEU A 53 19.874 78.321 14.291 1.00 0.00 H ATOM
819 1HB LEU A 53 19.407 75.728 12.754 1.00 0.00 H ATOM 820 2HB LEU
A 53 20.106 77.112 12.014 1.00 0.00 H ATOM 821 HG LEU A 53 17.336
76.870 13.377 1.00 0.00 H ATOM 822 1HD1 LEU A 53 16.830 79.056
13.024 1.00 0.00 H ATOM 823 2HD1 LEU A 53 18.521 79.331 13.257 1.00
0.00 H ATOM 824 3HD1 LEU A 53 17.754 79.272 11.609 1.00 0.00 H ATOM
825 1HD2 LEU A 53 16.302 76.848 11.201 1.00 0.00 H ATOM 826 2HD2
LEU A 53 17.862 77.101 10.346 1.00 0.00 H ATOM 827 3HD2 LEU A 53
17.544 75.602 11.226 1.00 0.00 H ATOM 828 N ASN A 54 18.372 77.405
15.998 1.00 0.09 N ATOM 829 CA ASN A 54 17.529 76.854 17.013 1.00
0.09 C ATOM 830 C ASN A 54 16.131 77.235 16.666 1.00 0.09 C ATOM
831 O ASN A 54 15.849 78.395 16.374 1.00 0.09 O ATOM 832 CB ASN A
54 17.800 77.421 18.416 1.00 0.09 C ATOM 833 CG ASN A 54 16.982
76.612 19.411 1.00 0.09 C ATOM 834 OD1 ASN A 54 16.409 75.580
19.069 1.00 0.09 O ATOM 835 ND2 ASN A 54 16.916 77.099 20.679 1.00
0.09 N ATOM 836 H ASN A 54 18.265 78.392 15.833 1.00 0.00 H ATOM
837 HA ASN A 54 17.682 75.775 17.052 1.00 0.00 H ATOM 838 1HB ASN A
54 17.555 78.493 18.473 1.00 0.00 H ATOM 839 2HB ASN A 54 18.867
77.298 18.670 1.00 0.00 H ATOM 840 1HD2 ASN A 54 17.381 77.945
20.949 1.00 0.00 H ATOM 841 2HD2 ASN A 54 16.363 76.577 21.336 1.00
0.00 H ATOM 842 N ILE A 55 15.213 76.255 16.677 1.00 0.08 N ATOM
843 CA ILE A 55 13.854 76.575 16.377 1.00 0.08 C ATOM 844 C ILE A
55 13.041 76.131 17.542 1.00 0.08 C ATOM 845 O ILE A 55 13.338
75.121 18.178 1.00 0.08 O ATOM 846 CB ILE A 55 13.310 75.856 15.178
1.00 0.08 C ATOM 847 CG1 ILE A 55 13.293 74.339 15.424 1.00 0.08 C
ATOM 848 CG2 ILE A 55 14.135 76.277 13.950 1.00 0.08 C ATOM 849 CD1
ILE A 55 12.481 73.570 14.384 1.00 0.08 C ATOM 850 H ILE A 55
15.434 75.327 17.030 1.00 0.00 H ATOM 851 HA ILE A 55 13.731 77.661
16.238 1.00 0.00 H ATOM 852 HB ILE A 55 12.270 76.207 15.038 1.00
0.00 H ATOM 853 1HG1 ILE A 55 12.813 74.025 16.355 1.00 0.00 H ATOM
854 2HG1 ILE A 55 14.341 74.014 15.420 1.00 0.00 H ATOM 855 1HG2
ILE A 55 13.703 75.895 13.010 1.00 0.00 H ATOM 856 2HG2 ILE A 55
14.181 77.375 13.855 1.00 0.00 H ATOM 857 3HG2 ILE A 55 15.169
75.900 14.004 1.00 0.00 H ATOM 858 1HD1 ILE A 55 12.528 72.482
14.547 1.00 0.00 H ATOM 859 2HD1 ILE A 55 11.433 73.877 14.474 1.00
0.00 H ATOM 860 3HD1 ILE A 55 12.805 73.762 13.349 1.00 0.00 H ATOM
861 N VAL A 56 11.988 76.902 17.855 1.00 0.10 N ATOM 862 CA VAL A
56 11.128 76.559 18.942 1.00 0.10 C ATOM 863 C VAL A 56 9.803
76.269 18.333 1.00 0.10 C ATOM 864 O VAL A 56 9.483 76.775 17.259
1.00 0.10 O ATOM 865 CB VAL A 56 10.938 77.689 19.914 1.00 0.10 C
ATOM 866 CG1 VAL A 56 9.887 77.287 20.962 1.00 0.10 C ATOM 867 CG2
VAL A 56 12.308 78.053 20.510 1.00 0.10 C ATOM 868 H VAL A 56
11.643 77.623 17.244 1.00 0.00 H ATOM 869 HA VAL A 56 11.486 75.619
19.322 1.00 0.00 H ATOM 870 HB VAL A 56 10.550 78.573 19.374 1.00
0.00 H ATOM 871 1HG1 VAL A 56 10.078 77.797 21.922 1.00 0.00 H ATOM
872 2HG1 VAL A 56 8.900 77.663 20.639 1.00 0.00 H ATOM 873 3HG1 VAL
A 56 9.712 76.240 21.212 1.00 0.00 H ATOM 874 1HG2 VAL A 56 12.215
78.754 21.355 1.00 0.00 H ATOM 875 2HG2 VAL A 56 12.874 77.183
20.866 1.00 0.00 H ATOM 876 3HG2 VAL A 56 12.944 78.553 19.759 1.00
0.00 H ATOM 877 N ASN A 57 9.004 75.433 19.021 1.00 0.11 N ATOM 878
CA ASN A 57 7.708 75.064 18.547 1.00 0.11 C ATOM 879 C ASN A 57
7.819 74.611 17.129 1.00 0.11 C ATOM 880 O ASN A 57 7.234 75.209
16.227 1.00 0.11 O ATOM 881 CB ASN A 57 6.662 76.188 18.634 1.00
0.11 C ATOM 882 CG ASN A 57 5.291 75.545 18.470 1.00 0.11 C ATOM
883 OD1 ASN A 57 5.099 74.663 17.634 1.00 0.11 O ATOM 884 ND2 ASN A
57 4.310 75.986 19.303 1.00 0.11 N ATOM 885 H ASN A 57 9.360 74.950
19.839 1.00 0.00 H ATOM 886 HA ASN A 57 7.598 74.194 19.108 1.00
0.00 H ATOM 887 1HB ASN A 57 6.807 76.960 17.861 1.00 0.00 H ATOM
888 2HB ASN A 57 6.743 76.690 19.613 1.00 0.00 H ATOM 889 1HD2 ASN
A 57 4.556 76.658 20.013 1.00 0.00 H ATOM 890 2HD2 ASN A 57 3.546
75.358 19.482 1.00 0.00 H ATOM 891 N ALA A 58 8.603 73.540 16.895
1.00 0.21 N ATOM 892 CA ALA A 58 8.722 73.047 15.556 1.00 0.21 C
ATOM 893 C ALA A 58 7.341 72.692 15.120 1.00 0.21 C ATOM 894 O ALA
A 58 6.578 72.084 15.870 1.00 0.21 O ATOM 895 CB ALA A 58 9.596
71.785 15.430 1.00 0.21 C ATOM 896 H ALA A 58 9.197 73.133
17.613
1.00 0.00 H ATOM 897 HA ALA A 58 9.154 73.899 15.035 1.00 0.00 H
ATOM 898 1HB ALA A 58 9.729 71.530 14.369 1.00 0.00 H ATOM 899 2HB
ALA A 58 10.589 71.945 15.874 1.00 0.00 H ATOM 900 3HB ALA A 58
9.118 70.934 15.936 1.00 0.00 H ATOM 901 N LYS A 59 6.977 73.095
13.889 1.00 0.31 N ATOM 902 CA LYS A 59 5.653 72.852 13.401 1.00
0.31 C ATOM 903 C LYS A 59 5.671 71.665 12.498 1.00 0.31 C ATOM 904
O LYS A 59 6.710 71.054 12.255 1.00 0.31 O ATOM 905 CB LYS A 59
5.066 74.025 12.597 1.00 0.31 C ATOM 906 CG LYS A 59 4.819 75.274
13.445 1.00 0.31 C ATOM 907 CD LYS A 59 3.812 75.062 14.579 1.00
0.31 C ATOM 908 CE LYS A 59 3.593 76.308 15.443 1.00 0.31 C ATOM
909 NZ LYS A 59 2.607 76.020 16.509 1.00 0.31 N1+ ATOM 910 H LYS A
59 7.667 73.546 13.283 1.00 0.00 H ATOM 911 HA LYS A 59 4.994
72.593 14.243 1.00 0.00 H ATOM 912 1HB LYS A 59 4.188 73.779 11.986
1.00 0.00 H ATOM 913 2HB LYS A 59 5.917 74.358 11.995 1.00 0.00 H
ATOM 914 1HG LYS A 59 4.449 76.103 12.824 1.00 0.00 H ATOM 915 2HG
LYS A 59 5.784 75.617 13.863 1.00 0.00 H ATOM 916 1HD LYS A 59
4.154 74.242 15.231 1.00 0.00 H ATOM 917 2HD LYS A 59 2.851 74.742
14.138 1.00 0.00 H ATOM 918 1HE LYS A 59 3.202 77.149 14.846 1.00
0.00 H ATOM 919 2HE LYS A 59 4.527 76.641 15.925 1.00 0.00 H ATOM
920 1HZ LYS A 59 2.435 76.829 17.091 1.00 0.00 H ATOM 921 2HZ LYS A
59 1.719 75.717 16.136 1.00 0.00 H ATOM 922 3HZ LYS A 59 2.973
75.299 17.120 1.00 0.00 H ATOM 923 N PHE A 60 4.477 71.314 11.983
1.00 0.23 N ATOM 924 CA PHE A 60 4.318 70.228 11.063 1.00 0.23 C
ATOM 925 C PHE A 60 5.095 70.579 9.839 1.00 0.23 C ATOM 926 O PHE A
60 5.704 69.726 9.197 1.00 0.23 O ATOM 927 CB PHE A 60 2.858 70.016
10.632 1.00 0.23 C ATOM 928 CG PHE A 60 2.873 69.034 9.510 1.00
0.23 C ATOM 929 CD1 PHE A 60 2.961 67.682 9.748 1.00 0.23 C ATOM
930 CD2 PHE A 60 2.798 69.475 8.208 1.00 0.23 C ATOM 931 CE1 PHE A
60 2.977 66.787 8.705 1.00 0.23 C ATOM 932 CE2 PHE A 60 2.813
68.584 7.161 1.00 0.23 C ATOM 933 CZ PHE A 60 2.902 67.236 7.409
1.00 0.23 C ATOM 934 H PHE A 60 3.633 71.764 12.295 1.00 0.00 H
ATOM 935 HA PHE A 60 4.520 69.253 11.406 1.00 0.00 H ATOM 936 1HB
PHE A 60 2.378 70.957 10.321 1.00 0.00 H ATOM 937 2HB PHE A 60
2.278 69.639 11.490 1.00 0.00 H ATOM 938 HD1 PHE A 60 3.027 67.313
10.769 1.00 0.00 H ATOM 939 HD2 PHE A 60 2.735 70.540 7.999 1.00
0.00 H ATOM 940 HE1 PHE A 60 3.056 65.721 8.908 1.00 0.00 H ATOM
941 HE2 PHE A 60 2.763 68.947 6.138 1.00 0.00 H ATOM 942 HZ PHE A
60 2.922 66.528 6.584 1.00 0.00 H ATOM 943 N GLU A 61 5.095 71.879
9.508 1.00 0.15 N ATOM 944 CA GLU A 61 5.748 72.420 8.354 1.00 0.15
C ATOM 945 C GLU A 61 7.218 72.152 8.459 1.00 0.15 C ATOM 946 O GLU
A 61 7.889 71.928 7.454 1.00 0.15 O ATOM 947 CB GLU A 61 5.528
73.936 8.259 1.00 0.15 C ATOM 948 CG GLU A 61 5.975 74.676 9.522
1.00 0.15 C ATOM 949 CD GLU A 61 5.349 76.063 9.510 1.00 0.15 C
ATOM 950 OE1 GLU A 61 5.260 76.667 8.408 1.00 0.15 O ATOM 951 OE2
GLU A 61 4.938 76.533 10.605 1.00 0.15 O1- ATOM 952 H GLU A 61
4.636 72.552 10.097 1.00 0.00 H ATOM 953 HA GLU A 61 5.382 71.916
7.445 1.00 0.00 H ATOM 954 1HB GLU A 61 4.456 74.129 8.074 1.00
0.00 H ATOM 955 2HB GLU A 61 6.074 74.289 7.366 1.00 0.00 H ATOM
956 1HG GLU A 61 7.066 74.750 9.599 1.00 0.00 H ATOM 957 2HG GLU A
61 5.569 74.098 10.323 1.00 0.00 H ATOM 958 N ASP A 62 7.751 72.147
9.694 1.00 0.16 N ATOM 959 CA ASP A 62 9.160 71.997 9.932 1.00 0.16
C ATOM 960 C ASP A 62 9.664 70.682 9.421 1.00 0.16 C ATOM 961 O ASP
A 62 10.828 70.586 9.041 1.00 0.16 O ATOM 962 CB ASP A 62 9.539
72.120 11.419 1.00 0.16 C ATOM 963 CG ASP A 62 9.413 73.590 11.797
1.00 0.16 C ATOM 964 OD1 ASP A 62 9.136 74.412 10.883 1.00 0.16 O
ATOM 965 OD2 ASP A 62 9.605 73.914 13.000 1.00 0.16 O1- ATOM 966 H
ASP A 62 7.202 72.371 10.507 1.00 0.00 H ATOM 967 HA ASP A 62 9.712
72.751 9.343 1.00 0.00 H ATOM 968 1HB ASP A 62 10.604 71.848 11.527
1.00 0.00 H ATOM 969 2HB ASP A 62 9.012 71.445 12.095 1.00 0.00 H
ATOM 970 N SER A 63 8.832 69.622 9.415 1.00 0.20 N ATOM 971 CA SER
A 63 9.308 68.342 8.962 1.00 0.20 C ATOM 972 C SER A 63 9.869
68.484 7.579 1.00 0.20 C ATOM 973 O SER A 63 9.321 69.189 6.734
1.00 0.20 O ATOM 974 CB SER A 63 8.213 67.262 8.921 1.00 0.20 C
ATOM 975 OG SER A 63 7.222 67.611 7.966 1.00 0.20 O ATOM 976 H SER
A 63 7.856 69.781 9.622 1.00 0.00 H ATOM 977 HA SER A 63 10.093
68.029 9.673 1.00 0.00 H ATOM 978 1HB SER A 63 7.772 67.106 9.916
1.00 0.00 H ATOM 979 2HB SER A 63 8.648 66.313 8.584 1.00 0.00 H
ATOM 980 HG SER A 63 6.731 68.382 8.306 1.00 0.00 H ATOM 981 N GLY
A 64 11.016 67.816 7.328 1.00 0.22 N ATOM 982 CA GLY A 64 11.651
67.892 6.044 1.00 0.22 C ATOM 983 C GLY A 64 13.081 67.501 6.233
1.00 0.22 C ATOM 984 O GLY A 64 13.461 66.997 7.288 1.00 0.22 O
ATOM 985 H GLY A 64 11.410 67.173 8.006 1.00 0.00 H ATOM 986 1HA
GLY A 64 11.494 68.851 5.553 1.00 0.00 H ATOM 987 2HA GLY A 64
11.200 67.149 5.359 1.00 0.00 H ATOM 988 N GLU A 65 13.918 67.728
5.199 1.00 0.19 N ATOM 989 CA GLU A 65 15.307 67.383 5.302 1.00
0.19 C ATOM 990 C GLU A 65 16.074 68.644 5.515 1.00 0.19 C ATOM 991
O GLU A 65 15.711 69.702 5.000 1.00 0.19 O ATOM 992 CB GLU A 65
15.910 66.744 4.040 1.00 0.19 C ATOM 993 CG GLU A 65 15.403 65.337
3.730 1.00 0.19 C ATOM 994 CD GLU A 65 16.200 64.821 2.539 1.00
0.19 C ATOM 995 OE1 GLU A 65 16.409 65.606 1.575 1.00 0.19 O ATOM
996 OE2 GLU A 65 16.625 63.635 2.584 1.00 0.19 O1- ATOM 997 H GLU A
65 13.592 68.118 4.323 1.00 0.00 H ATOM 998 HA GLU A 65 15.418
66.667 6.112 1.00 0.00 H ATOM 999 1HB GLU A 65 16.996 66.696 4.211
1.00 0.00 H ATOM 1000 2HB GLU A 65 15.743 67.417 3.182 1.00 0.00 H
ATOM 1001 1HG GLU A 65 14.334 65.361 3.473 1.00 0.00 H ATOM 1002
2HG GLU A 65 15.576 64.670 4.587 1.00 0.00 H ATOM 1003 N TYR A 66
17.164 68.560 6.304 1.00 0.22 N ATOM 1004 CA TYR A 66 17.970 69.718
6.549 1.00 0.22 C ATOM 1005 C TYR A 66 19.342 69.441 6.020 1.00
0.22 C ATOM 1006 O TYR A 66 19.839 68.318 6.099 1.00 0.22 O ATOM
1007 CB TYR A 66 18.124 70.071 8.040 1.00 0.22 C ATOM 1008 CG TYR A
66 16.782 70.448 8.567 1.00 0.22 C ATOM 1009 CD1 TYR A 66 15.918
69.482 9.033 1.00 0.22 C ATOM 1010 CD2 TYR A 66 16.382 71.764 8.592
1.00 0.22 C ATOM 1011 CE1 TYR A 66 14.679 69.825 9.522 1.00 0.22 C
ATOM 1012 CE2 TYR A 66 15.144 72.114 9.078 1.00 0.22 C ATOM 1013 CZ
TYR A 66 14.291 71.143 9.544 1.00 0.22 C ATOM 1014 OH TYR A 66
13.021 71.499 10.044 1.00 0.22 O ATOM 1015 H TYR A 66 17.342 67.720
6.847 1.00 0.00 H ATOM 1016 HA TYR A 66 17.532 70.591 6.047 1.00
0.00 H ATOM 1017 1HB TYR A 66 18.806 70.937 8.084 1.00 0.00 H ATOM
1018 2HB TYR A 66 18.599 69.314 8.651 1.00 0.00 H ATOM 1019 HD1 TYR
A 66 16.191 68.433 9.006 1.00 0.00 H ATOM 1020 HD2 TYR A 66 17.046
72.541 8.220 1.00 0.00 H ATOM 1021 HE1 TYR A 66 13.997 69.066 9.847
1.00 0.00 H ATOM 1022 HE2 TYR A 66 14.837 73.158 9.089 1.00 0.00 H
ATOM 1023 HH TYR A 66 12.339 71.120 9.464 1.00 0.00 H ATOM 1024 N
LYS A 67 19.979 70.475 5.440 1.00 0.45 N ATOM 1025 CA LYS A 67
21.299 70.333 4.900 1.00 0.45 C ATOM 1026 C LYS A 67 22.038 71.587
5.238 1.00 0.45 C ATOM 1027 O LYS A 67 21.429 72.627 5.482 1.00
0.45 O ATOM 1028 CB LYS A 67 21.302 70.211 3.371 1.00 0.45 C ATOM
1029 CG LYS A 67 20.591 68.953 2.871 1.00 0.45 C ATOM 1030 CD LYS A
67 20.205 69.019 1.394 1.00 0.45 C ATOM 1031 CE LYS A 67 18.982
69.902 1.129 1.00 0.45 C ATOM 1032 NZ LYS A 67 17.786 69.303 1.761
1.00 0.45 N1+ ATOM 1033 H LYS A 67 19.577 71.404 5.412 1.00 0.00 H
ATOM 1034 HA LYS A 67 21.802 69.466 5.361 1.00 0.00 H ATOM 1035 1HB
LYS A 67 22.349 70.191 3.016 1.00 0.00 H ATOM 1036 2HB LYS A 67
20.856 71.125 2.952 1.00 0.00 H ATOM 1037 1HG LYS A 67 19.696
68.714 3.468 1.00 0.00 H ATOM 1038 2HG LYS A 67 21.325 68.161 3.088
1.00 0.00 H ATOM 1039 1HD LYS A 67 19.999 68.030 0.954 1.00 0.00 H
ATOM 1040 2HD LYS A 67 21.053 69.426 0.812 1.00 0.00 H ATOM 1041
1HE LYS A 67 18.775 69.982 0.049 1.00 0.00 H ATOM 1042 2HE LYS A 67
19.096 70.919 1.529 1.00 0.00 H ATOM 1043 1HZ LYS A 67 16.927
69.761 1.486 1.00 0.00 H ATOM 1044 2HZ LYS A 67 17.669 68.327 1.501
1.00 0.00 H ATOM 1045 3HZ LYS A 67 17.829 69.331 2.772 1.00 0.00 H
ATOM 1046 N CYS A 68 23.383 71.512 5.281 1.00 0.52 N ATOM 1047 CA
CYS A 68 24.163 72.670 5.606 1.00 0.52 C ATOM 1048 C CYS A 68
25.428 72.644 4.811 1.00 0.52 C ATOM 1049 O CYS A 68 25.970 71.578
4.524 1.00 0.52 O ATOM 1050 CB CYS A 68 24.621 72.687 7.065 1.00
0.52 C ATOM 1051 SG CYS A 68 25.956 73.885 7.311 1.00 0.52 S ATOM
1052 H CYS A 68 23.896 70.694 5.003 1.00 0.00 H ATOM 1053 HA CYS A
68 23.591 73.579 5.374 1.00 0.00 H ATOM 1054 1HB CYS A 68 24.992
71.688 7.349 1.00 0.00 H ATOM 1055 2HB CYS A 68 23.803 72.945 7.724
1.00 0.00 H ATOM 1056 N GLN A 69 25.931 73.832 4.420 1.00 0.27 N
ATOM 1057 CA GLN A 69 27.206 73.865 3.771 1.00 0.27 C ATOM 1058 C
GLN A 69 27.926 75.086 4.234 1.00 0.27 C ATOM 1059 O GLN A 69
27.323 76.038 4.727 1.00 0.27 O ATOM 1060 CB GLN A 69 27.150 73.939
2.237 1.00 0.27 C ATOM 1061 CG GLN A 69 26.530 75.227 1.700 1.00
0.27 C ATOM 1062 CD GLN A 69 26.687 75.210 0.186 1.00 0.27 C ATOM
1063 OE1 GLN A 69 27.435 74.400 -0.360 1.00 0.27 O ATOM 1064 NE2
GLN A 69 25.967 76.130 -0.511 1.00 0.27 N ATOM 1065 H GLN A 69
25.524 74.715 4.697 1.00 0.00 H ATOM 1066 HA GLN A 69 27.798 72.992
4.081 1.00 0.00 H ATOM 1067 1HB GLN A 69 26.598 73.064 1.859 1.00
0.00 H ATOM 1068 2HB GLN A 69 28.189 73.841 1.876 1.00 0.00 H ATOM
1069 1HG GLN A 69 27.185 76.031 2.029 1.00 0.00 H ATOM 1070 2HG GLN
A 69 25.497 75.374 2.036 1.00 0.00 H ATOM 1071 1HE2 GLN A 69 25.234
76.647 -0.068 1.00 0.00 H ATOM 1072 2HE2 GLN A 69 25.927 75.922
-1.496 1.00 0.00 H ATOM 1073 N HIS A 70 29.263 75.063 4.102 1.00
0.11 N ATOM 1074 CA HIS A 70 30.076 76.188 4.443 1.00 0.11 C ATOM
1075 C HIS A 70 30.899 76.470 3.237 1.00 0.11 C ATOM 1076 O HIS A
70 30.877 75.716 2.267 1.00 0.11 O ATOM 1077 CB HIS A 70 31.043
75.946 5.612 1.00 0.11 C ATOM 1078 CG HIS A 70 30.339 75.869 6.930
1.00 0.11 C ATOM 1079 ND1 HIS A 70 29.937 76.975 7.646 1.00 0.11 N
ATOM 1080 CD2 HIS A 70 29.953 74.791 7.664 1.00 0.11 C ATOM 1081
CE1 HIS A 70 29.331 76.515 8.768 1.00 0.11 C ATOM 1082 NE2 HIS A 70
29.316 75.195 8.824 1.00 0.11 N ATOM 1083 H HIS A 70 29.699 74.376
3.501 1.00 0.00 H ATOM 1084 HA HIS A 70 29.447 77.067 4.660 1.00
0.00 H ATOM 1085 1HB HIS A 70 31.767 76.777 5.657 1.00 0.00 H ATOM
1086 2HB HIS A 70 31.637 75.036 5.471 1.00 0.00 H ATOM 1087 HD2 HIS
A 70 30.099 73.743 7.447 1.00 0.00 H ATOM 1088 HE1 HIS A 70 29.020
77.159 9.580 1.00 0.00 H ATOM 1089 HE2 HIS A 70 29.016 74.625 9.592
1.00 0.00 H ATOM 1090 N GLN A 71 31.625 77.600 3.251 1.00 0.12 N
ATOM 1091 CA GLN A 71 32.441 77.912 2.121 1.00 0.12 C ATOM 1092 C
GLN A 71 33.468 76.834 2.009 1.00 0.12 C ATOM 1093 O GLN A 71
33.753 76.341 0.920 1.00 0.12 O ATOM 1094 CB GLN A 71 33.197 79.243
2.276 1.00 0.12 C ATOM 1095 CG GLN A 71 32.304 80.487 2.279 1.00
0.12 C ATOM 1096 CD GLN A 71 31.895 80.783 0.843 1.00 0.12 C ATOM
1097 OE1 GLN A 71 32.123 79.983 -0.063 1.00 0.12 O ATOM 1098 NE2
GLN A 71 31.272 81.970 0.623 1.00 0.12 N ATOM 1099 H GLN A 71
31.670 78.217 4.051 1.00 0.00 H ATOM 1100 HA GLN A 71 31.834 77.889
1.204 1.00 0.00 H ATOM 1101 1HB GLN A 71 33.962 79.321 1.481 1.00
0.00 H ATOM 1102 2HB GLN A 71 33.758 79.212 3.225 1.00 0.00 H ATOM
1103 1HG GLN A 71 32.874 81.347 2.668 1.00 0.00 H ATOM 1104 2HG GLN
A 71 31.411 80.332 2.901 1.00 0.00 H ATOM 1105 1HE2 GLN A 71 31.126
82.615 1.391 1.00 0.00 H ATOM 1106 2HE2 GLN A 71 31.056 82.232
-0.322 1.00 0.00 H ATOM 1107 N GLN A 72 34.046 76.440 3.157 1.00
0.21 N ATOM 1108 CA GLN A 72 35.117 75.489 3.188 1.00 0.21 C ATOM
1109 C GLN A 72 34.660 74.129 2.761 1.00 0.21 C ATOM 1110 O GLN A
72 35.308 73.483 1.940 1.00 0.21 O ATOM 1111 CB GLN A 72 35.698
75.320 4.602 1.00 0.21 C ATOM 1112 CG GLN A 72 36.104 76.644 5.252
1.00 0.21 C ATOM 1113 CD GLN A 72 37.057 77.372 4.316 1.00 0.21 C
ATOM 1114 OE1 GLN A 72 37.630 76.784 3.400 1.00 0.21 O ATOM 1115
NE2 GLN A 72 37.224 78.701 4.547 1.00 0.21 N ATOM 1116 H GLN A 72
33.776 76.855 4.029 1.00 0.00 H ATOM 1117 HA GLN A 72 35.857 75.781
2.433 1.00 0.00 H ATOM 1118 1HB GLN A 72 36.568 74.648 4.507 1.00
0.00 H ATOM 1119 2HB GLN A 72 34.952 74.810 5.225 1.00 0.00 H ATOM
1120 1HG GLN A 72 36.614 76.581 6.211 1.00 0.00 H ATOM 1121 2HG GLN
A 72 35.212 77.270 5.418 1.00 0.00 H ATOM 1122 1HE2 GLN A 72 36.792
79.141 5.341 1.00 0.00 H ATOM 1123 2HE2 GLN A 72 37.891 79.177
3.967 1.00 0.00 H ATOM 1124 N VAL A 73 33.516 73.660 3.298 1.00
0.31 N ATOM 1125 CA VAL A 73 33.130 72.297 3.072 1.00 0.31 C ATOM
1126 C VAL A 73 32.145 72.164 1.959 1.00 0.31 C ATOM 1127 O VAL A
73 31.658 73.139 1.388 1.00 0.31 O ATOM 1128 CB VAL A 73 32.521
71.650 4.283 1.00 0.31 C ATOM 1129 CG1 VAL A 73 33.583 71.602 5.395
1.00 0.31 C ATOM 1130 CG2 VAL A 73 31.247 72.424 4.666 1.00 0.31 C
ATOM 1131 H VAL A 73 32.902 74.241 3.836 1.00 0.00 H ATOM 1132 HA
VAL A 73 34.032 71.730 2.786 1.00 0.00 H ATOM 1133 HB VAL A 73
32.166 70.641 4.101 1.00 0.00 H ATOM 1134 1HG1 VAL A 73 33.219
71.046 6.275 1.00 0.00 H ATOM 1135 2HG1 VAL A 73 34.505 71.104
5.053 1.00 0.00 H ATOM 1136 3HG1 VAL A 73 33.855 72.612 5.740 1.00
0.00 H ATOM 1137 1HG2 VAL A 73 31.260 72.697 5.729 1.00 0.00 H ATOM
1138 2HG2 VAL A 73 31.174 73.376 4.129 1.00 0.00 H ATOM 1139 3HG2
VAL A 73 30.331 71.901 4.407 1.00 0.00 H ATOM 1140 N ASN A 74
31.857 70.887 1.634 1.00 0.41 N ATOM 1141 CA ASN A 74 30.932 70.453
0.630 1.00 0.41 C ATOM 1142 C ASN A 74 29.580 70.504 1.270 1.00
0.41 C ATOM 1143 O ASN A 74 29.409 71.115 2.322 1.00 0.41 O ATOM
1144 CB ASN A 74 31.202 68.997 0.200 1.00 0.41 C ATOM 1145 CG ASN A
74 30.458 68.687 -1.090 1.00 0.41 C ATOM 1146 OD1 ASN A 74 29.812
69.553 -1.676 1.00 0.41 O ATOM 1147 ND2 ASN A 74 30.542 67.407
-1.542 1.00 0.41 N ATOM 1148 H ASN A 74 32.331 70.149 2.145 1.00
0.00 H ATOM 1149 HA ASN A 74 30.976 71.153 -0.222 1.00 0.00 H ATOM
1150 1HB ASN A 74 30.921 68.305 1.004 1.00 0.00 H ATOM 1151 2HB ASN
A 74 32.278 68.864 -0.003 1.00 0.00 H ATOM 1152 1HD2 ASN A 74
30.976 66.687 -0.997 1.00 0.00 H ATOM 1153 2HD2 ASN A 74 29.971
67.179 -2.339 1.00 0.00 H ATOM 1154 N GLU A 75 28.567 69.896 0.622
1.00 0.48 N ATOM 1155 CA GLU A 75 27.249 69.863 1.180 1.00 0.48 C
ATOM 1156 C GLU A 75 27.241 68.797 2.228 1.00 0.48 C ATOM 1157 O
GLU A 75 27.925 67.781 2.100 1.00 0.48 O ATOM 1158 CB GLU A 75
26.170 69.500 0.145 1.00 0.48 C ATOM 1159 CG GLU A 75 26.047 70.526
-0.982 1.00 0.48 C ATOM 1160 CD GLU A 75 25.367 71.763 -0.418 1.00
0.48 C ATOM 1161 OE1 GLU A 75 24.699 71.637 0.643 1.00 0.48 O ATOM
1162 OE2 GLU A 75 25.503 72.851 -1.039 1.00 0.48 O1- ATOM 1163 H
GLU A 75 28.657 69.614 -0.346 1.00 0.00 H ATOM 1164 HA GLU A 75
27.017 70.847 1.621 1.00 0.00 H ATOM 1165 1HB GLU A 75 25.207
69.347 0.665 1.00 0.00 H ATOM 1166 2HB GLU A 75 26.423 68.509
-0.272 1.00 0.00 H ATOM 1167 1HG GLU A 75 25.416 70.134 -1.797 1.00
0.00 H ATOM 1168 2HG GLU A 75 27.009 70.787 -1.450 1.00 0.00 H ATOM
1169 N SER A 76 26.469 69.018 3.309 1.00 0.42 N ATOM 1170 CA SER A
76 26.382 68.066 4.377 1.00 0.42 C ATOM 1171 C SER A 76 25.336
67.064 4.009 1.00 0.42 C ATOM 1172 O SER A 76 24.507 67.313 3.136
1.00 0.42 O ATOM 1173 CB SER A 76 25.956 68.704 5.710 1.00 0.42 C
ATOM 1174 OG SER A 76 25.873 67.713 6.720 1.00 0.42 O ATOM 1175 H
SER A 76 26.027 69.921 3.444 1.00 0.00 H ATOM 1176 HA SER A 76
27.347 67.548 4.497 1.00 0.00 H ATOM 1177 1HB SER A 76 24.918
69.048 5.529 1.00 0.00 H ATOM 1178 2HB SER A 76 26.368 69.600 6.179
1.00 0.00 H ATOM 1179 HG SER A 76 25.075 67.185 6.523 1.00 0.00 H
ATOM 1180 N GLU A 77 25.365 65.881 4.660 1.00 0.31 N ATOM 1181 CA
GLU A 77 24.357 64.903 4.380 1.00 0.31 C ATOM 1182 C GLU A 77
23.106 65.426 4.998 1.00 0.31 C ATOM 1183 O GLU A 77 23.138 66.145
5.994 1.00 0.31 O ATOM 1184 CB GLU A 77 24.596 63.527 5.023 1.00
0.31 C ATOM 1185 CG GLU A 77 25.878 62.834 4.571 1.00 0.31 C ATOM
1186 CD GLU A 77 26.987 63.328 5.483 1.00 0.31 C ATOM 1187 OE1 GLU
A 77 26.707 63.507 6.699 1.00 0.31 O ATOM 1188 OE2 GLU A 77 28.123
63.535 4.981 1.00 0.31 O1- ATOM 1189 H GLU A 77 26.107 65.592 5.291
1.00 0.00 H ATOM 1190 HA GLU A 77 24.351 64.725 3.293 1.00 0.00 H
ATOM 1191 1HB GLU A 77 23.730 62.916 4.704 1.00 0.00 H ATOM 1192
2HB GLU A 77 24.496 63.579 6.121 1.00 0.00 H ATOM 1193 1HG GLU A 77
26.103 63.000 3.506 1.00 0.00 H ATOM 1194 2HG GLU A 77 25.778
61.745
4.715 1.00 0.00 H ATOM 1195 N PRO A 78 22.004 65.094 4.398 1.00
0.29 N ATOM 1196 CA PRO A 78 20.764 65.579 4.932 1.00 0.29 C ATOM
1197 C PRO A 78 20.323 64.843 6.154 1.00 0.29 C ATOM 1198 O PRO A
78 20.684 63.679 6.323 1.00 0.29 O ATOM 1199 CB PRO A 78 19.756
65.509 3.788 1.00 0.29 C ATOM 1200 CG PRO A 78 20.627 65.643 2.527
1.00 0.29 C ATOM 1201 CD PRO A 78 21.979 65.042 2.944 1.00 0.29 C
ATOM 1202 HA PRO A 78 20.930 66.637 5.154 1.00 0.00 H ATOM 1203 1HB
PRO A 78 18.975 66.271 3.881 1.00 0.00 H ATOM 1204 2HB PRO A 78
19.253 64.526 3.777 1.00 0.00 H ATOM 1205 1HG PRO A 78 20.743
66.647 2.155 1.00 0.00 H ATOM 1206 2HG PRO A 78 20.192 65.085 1.679
1.00 0.00 H ATOM 1207 1HD PRO A 78 22.062 63.992 2.622 1.00 0.00 H
ATOM 1208 2HD PRO A 78 22.791 65.613 2.482 1.00 0.00 H ATOM 1209 N
VAL A 79 19.557 65.529 7.022 1.00 0.31 N ATOM 1210 CA VAL A 79
18.978 64.935 8.187 1.00 0.31 C ATOM 1211 C VAL A 79 17.507 65.106
8.006 1.00 0.31 C ATOM 1212 O VAL A 79 17.055 66.173 7.593 1.00
0.31 O ATOM 1213 CB VAL A 79 19.362 65.618 9.465 1.00 0.31 C ATOM
1214 CG1 VAL A 79 18.925 67.090 9.386 1.00 0.31 C ATOM 1215 CG2 VAL
A 79 18.732 64.848 10.638 1.00 0.31 C ATOM 1216 H VAL A 79 19.361
66.506 6.860 1.00 0.00 H ATOM 1217 HA VAL A 79 19.257 63.869 8.216
1.00 0.00 H ATOM 1218 HB VAL A 79 20.462 65.577 9.567 1.00 0.00 H
ATOM 1219 1HG1 VAL A 79 19.391 67.661 10.210 1.00 0.00 H ATOM 1220
2HG1 VAL A 79 19.283 67.547 8.460 1.00 0.00 H ATOM 1221 3HG1 VAL A
79 17.846 67.223 9.523 1.00 0.00 H ATOM 1222 1HG2 VAL A 79 19.088
65.237 11.607 1.00 0.00 H ATOM 1223 2HG2 VAL A 79 17.634 64.939
10.652 1.00 0.00 H ATOM 1224 3HG2 VAL A 79 18.990 63.776 10.606
1.00 0.00 H ATOM 1225 N TYR A 80 16.709 64.061 8.294 1.00 0.19 N
ATOM 1226 CA TYR A 80 15.305 64.228 8.067 1.00 0.19 C ATOM 1227 C
TYR A 80 14.649 64.401 9.394 1.00 0.19 C ATOM 1228 O TYR A 80
14.925 63.669 10.343 1.00 0.19 O ATOM 1229 CB TYR A 80 14.628
63.040 7.359 1.00 0.19 C ATOM 1230 CG TYR A 80 13.244 63.476 7.018
1.00 0.19 C ATOM 1231 CD1 TYR A 80 12.214 63.344 7.921 1.00 0.19 C
ATOM 1232 CD2 TYR A 80 12.983 64.029 5.785 1.00 0.19 C ATOM 1233
CE1 TYR A 80 10.942 63.754 7.597 1.00 0.19 C ATOM 1234 CE2 TYR A 80
11.714 64.441 5.454 1.00 0.19 C ATOM 1235 CZ TYR A 80 10.692 64.301
6.360 1.00 0.19 C ATOM 1236 OH TYR A 80 9.387 64.723 6.025 1.00
0.19 O ATOM 1237 H TYR A 80 17.008 63.184 8.683 1.00 0.00 H ATOM
1238 HA TYR A 80 15.134 65.090 7.415 1.00 0.00 H ATOM 1239 1HB TYR
A 80 14.633 62.141 7.994 1.00 0.00 H ATOM 1240 2HB TYR A 80 15.197
62.785 6.450 1.00 0.00 H ATOM 1241 HD1 TYR A 80 12.423 62.901 8.890
1.00 0.00 H ATOM 1242 HD2 TYR A 80 13.756 64.049 5.036 1.00 0.00 H
ATOM 1243 HE1 TYR A 80 10.137 63.698 8.310 1.00 0.00 H ATOM 1244
HE2 TYR A 80 11.519 64.850 4.465 1.00 0.00 H ATOM 1245 HH TYR A 80
8.972 65.029 6.840 1.00 0.00 H ATOM 1246 N LEU A 81 13.760 65.406
9.490 1.00 0.08 N ATOM 1247 CA LEU A 81 13.094 65.671 10.729 1.00
0.08 C ATOM 1248 C LEU A 81 11.635 65.423 10.529 1.00 0.08 C ATOM
1249 O LEU A 81 11.076 65.757 9.485 1.00 0.08 O ATOM 1250 CB LEU A
81 13.250 67.130 11.191 1.00 0.08 C ATOM 1251 CG LEU A 81 12.542
67.437 12.522 1.00 0.08 C ATOM 1252 CD1 LEU A 81 13.157 66.632
13.678 1.00 0.08 C ATOM 1253 CD2 LEU A 81 12.505 68.948 12.800 1.00
0.08 C ATOM 1254 H LEU A 81 13.531 65.997 8.697 1.00 0.00 H ATOM
1255 HA LEU A 81 13.489 64.991 11.494 1.00 0.00 H ATOM 1256 1HB LEU
A 81 12.768 67.742 10.414 1.00 0.00 H ATOM 1257 2HB LEU A 81 14.319
67.393 11.257 1.00 0.00 H ATOM 1258 HG LEU A 81 11.483 67.141
12.421 1.00 0.00 H ATOM 1259 1HD1 LEU A 81 12.405 66.346 14.427
1.00 0.00 H ATOM 1260 2HD1 LEU A 81 13.691 65.731 13.359 1.00 0.00
H ATOM 1261 3HD1 LEU A 81 13.915 67.235 14.207 1.00 0.00 H ATOM
1262 1HD2 LEU A 81 11.952 69.171 13.726 1.00 0.00 H ATOM 1263 2HD2
LEU A 81 13.519 69.368 12.903 1.00 0.00 H ATOM 1264 3HD2 LEU A 81
12.001 69.489 11.981 1.00 0.00 H ATOM 1265 N GLU A 82 10.987 64.798
11.529 1.00 0.09 N ATOM 1266 CA GLU A 82 9.582 64.537 11.444 1.00
0.09 C ATOM 1267 C GLU A 82 8.969 65.149 12.660 1.00 0.09 C ATOM
1268 O GLU A 82 9.443 64.940 13.776 1.00 0.09 O ATOM 1269 CB GLU A
82 9.250 63.035 11.486 1.00 0.09 C ATOM 1270 CG GLU A 82 9.774
62.251 10.282 1.00 0.09 C ATOM 1271 CD GLU A 82 9.587 60.767 10.568
1.00 0.09 C ATOM 1272 OE1 GLU A 82 8.557 60.408 11.201 1.00 0.09 O
ATOM 1273 OE2 GLU A 82 10.477 59.972 10.166 1.00 0.09 O1- ATOM 1274
H GLU A 82 11.437 64.495 12.385 1.00 0.00 H ATOM 1275 HA GLU A 82
9.165 64.964 10.521 1.00 0.00 H ATOM 1276 1HB GLU A 82 8.149 62.967
11.523 1.00 0.00 H ATOM 1277 2HB GLU A 82 9.643 62.600 12.420 1.00
0.00 H ATOM 1278 1HG GLU A 82 10.829 62.451 10.073 1.00 0.00 H ATOM
1279 2HG GLU A 82 9.148 62.474 9.408 1.00 0.00 H ATOM 1280 N VAL A
83 7.896 65.936 12.476 1.00 0.09 N ATOM 1281 CA VAL A 83 7.263
66.538 13.611 1.00 0.09 C ATOM 1282 C VAL A 83 5.907 65.928 13.711
1.00 0.09 C ATOM 1283 O VAL A 83 5.239 65.720 12.700 1.00 0.09 O
ATOM 1284 CB VAL A 83 7.069 68.016 13.470 1.00 0.09 C ATOM 1285 CG1
VAL A 83 8.451 68.684 13.377 1.00 0.09 C ATOM 1286 CG2 VAL A 83
6.170 68.268 12.250 1.00 0.09 C ATOM 1287 H VAL A 83 7.390 65.999
11.611 1.00 0.00 H ATOM 1288 HA VAL A 83 7.846 66.346 14.521 1.00
0.00 H ATOM 1289 HB VAL A 83 6.558 68.385 14.379 1.00 0.00 H ATOM
1290 1HG1 VAL A 83 8.397 69.772 13.515 1.00 0.00 H ATOM 1291 2HG1
VAL A 83 9.130 68.308 14.159 1.00 0.00 H ATOM 1292 3HG1 VAL A 83
8.933 68.497 12.403 1.00 0.00 H ATOM 1293 1HG2 VAL A 83 6.508
69.061 11.601 1.00 0.00 H ATOM 1294 2HG2 VAL A 83 6.129 67.447
11.520 1.00 0.00 H ATOM 1295 3HG2 VAL A 83 5.180 68.342 12.716 1.00
0.00 H ATOM 1296 N PHE A 84 5.469 65.606 14.943 1.00 0.23 N ATOM
1297 CA PHE A 84 4.182 64.994 15.076 1.00 0.23 C ATOM 1298 C PHE A
84 3.459 65.747 16.138 1.00 0.23 C ATOM 1299 O PHE A 84 4.077
66.424 16.959 1.00 0.23 O ATOM 1300 CB PHE A 84 4.229 63.552 15.606
1.00 0.23 C ATOM 1301 CG PHE A 84 5.215 62.773 14.810 1.00 0.23 C
ATOM 1302 CD1 PHE A 84 4.889 62.234 13.590 1.00 0.23 C ATOM 1303
CD2 PHE A 84 6.487 62.595 15.293 1.00 0.23 C ATOM 1304 CE1 PHE A 84
5.814 61.522 12.865 1.00 0.23 C ATOM 1305 CE2 PHE A 84 7.414 61.883
14.572 1.00 0.23 C ATOM 1306 CZ PHE A 84 7.081 61.341 13.357 1.00
0.23 C ATOM 1307 H PHE A 84 6.045 65.661 15.777 1.00 0.00 H ATOM
1308 HA PHE A 84 3.619 65.035 14.132 1.00 0.00 H ATOM 1309 1HB PHE
A 84 3.221 63.109 15.548 1.00 0.00 H ATOM 1310 2HB PHE A 84 4.503
63.548 16.673 1.00 0.00 H ATOM 1311 HD1 PHE A 84 3.881 62.359
13.203 1.00 0.00 H ATOM 1312 HD2 PHE A 84 6.776 63.092 16.211 1.00
0.00 H ATOM 1313 HE1 PHE A 84 5.532 61.066 11.919 1.00 0.00 H ATOM
1314 HE2 PHE A 84 8.434 62.194 14.641 1.00 0.00 H ATOM 1315 HZ PHE
A 84 7.738 60.588 13.011 1.00 0.00 H ATOM 1316 N SER A 85 2.115
65.679 16.131 1.00 0.34 N ATOM 1317 CA SER A 85 1.395 66.292 17.204
1.00 0.34 C ATOM 1318 C SER A 85 0.673 65.190 17.915 1.00 0.34 C
ATOM 1319 O SER A 85 -0.388 64.740 17.488 1.00 0.34 O ATOM 1320 CB
SER A 85 0.370 67.346 16.748 1.00 0.34 C ATOM 1321 OG SER A 85
-0.610 66.760 15.906 1.00 0.34 O ATOM 1322 H SER A 85 1.591 65.046
15.547 1.00 0.00 H ATOM 1323 HA SER A 85 2.077 66.796 17.905 1.00
0.00 H ATOM 1324 1HB SER A 85 0.858 68.148 16.180 1.00 0.00 H ATOM
1325 2HB SER A 85 -0.105 67.775 17.647 1.00 0.00 H ATOM 1326 HG SER
A 85 -0.897 65.942 16.364 1.00 0.00 H ATOM 1327 N ASP A 86 1.255
64.718 19.032 1.00 0.23 N ATOM 1328 CA ASP A 86 0.646 63.662 19.785
1.00 0.23 C ATOM 1329 C ASP A 86 0.958 63.925 21.219 1.00 0.23 C
ATOM 1330 O ASP A 86 1.850 64.710 21.535 1.00 0.23 O ATOM 1331 CB
ASP A 86 1.209 62.269 19.458 1.00 0.23 C ATOM 1332 CG ASP A 86
0.750 61.889 18.058 1.00 0.23 C ATOM 1333 OD1 ASP A 86 -0.436
62.161 17.730 1.00 0.23 O ATOM 1334 OD2 ASP A 86 1.581 61.328
17.294 1.00 0.23 O1- ATOM 1335 H ASP A 86 2.097 65.076 19.438 1.00
0.00 H ATOM 1336 HA ASP A 86 -0.450 63.676 19.655 1.00 0.00 H ATOM
1337 1HB ASP A 86 0.728 61.556 20.149 1.00 0.00 H ATOM 1338 2HB ASP
A 86 2.265 62.020 19.445 1.00 0.00 H ATOM 1339 N TRP A 87 0.199
63.299 22.136 1.00 0.14 N ATOM 1340 CA TRP A 87 0.482 63.500 23.524
1.00 0.14 C ATOM 1341 C TRP A 87 1.782 62.871 23.895 1.00 0.14 C
ATOM 1342 O TRP A 87 2.587 63.476 24.598 1.00 0.14 O ATOM 1343 CB
TRP A 87 -0.603 62.984 24.479 1.00 0.14 C ATOM 1344 CG TRP A 87
-1.760 63.943 24.577 1.00 0.14 C ATOM 1345 CD1 TRP A 87 -3.025
63.873 24.074 1.00 0.14 C ATOM 1346 CD2 TRP A 87 -1.660 65.206
25.254 1.00 0.14 C ATOM 1347 NE1 TRP A 87 -3.722 65.014 24.401 1.00
0.14 N ATOM 1348 CE2 TRP A 87 -2.892 65.844 25.126 1.00 0.14 C ATOM
1349 CE3 TRP A 87 -0.621 65.786 25.924 1.00 0.14 C ATOM 1350 CZ2
TRP A 87 -3.106 67.080 25.670 1.00 0.14 C ATOM 1351 CZ3 TRP A 87
-0.839 67.029 26.474 1.00 0.14 C ATOM 1352 CH2 TRP A 87 -2.058
67.665 26.350 1.00 0.14 C ATOM 1353 H TRP A 87 -0.549 62.677 21.872
1.00 0.00 H ATOM 1354 HA TRP A 87 0.614 64.581 23.692 1.00 0.00 H
ATOM 1355 1HB TRP A 87 -0.152 62.874 25.482 1.00 0.00 H ATOM 1356
2HB TRP A 87 -0.938 61.974 24.197 1.00 0.00 H ATOM 1357 HD1 TRP A
87 -3.478 63.070 23.505 1.00 0.00 H ATOM 1358 HE1 TRP A 87 -4.681
65.186 24.205 1.00 0.00 H ATOM 1359 HE3 TRP A 87 0.335 65.286
26.045 1.00 0.00 H ATOM 1360 HZ2 TRP A 87 -4.070 67.574 25.578 1.00
0.00 H ATOM 1361 HZ3 TRP A 87 -0.071 67.493 27.066 1.00 0.00 H ATOM
1362 HH2 TRP A 87 -2.209 68.629 26.826 1.00 0.00 H ATOM 1363 N LEU
A 88 2.035 61.637 23.423 1.00 0.12 N ATOM 1364 CA LEU A 88 3.244
60.972 23.818 1.00 0.12 C ATOM 1365 C LEU A 88 3.845 60.339 22.607
1.00 0.12 C ATOM 1366 O LEU A 88 3.126 59.888 21.717 1.00 0.12 O
ATOM 1367 CB LEU A 88 2.988 59.838 24.827 1.00 0.12 C ATOM 1368 CG
LEU A 88 4.252 59.089 25.294 1.00 0.12 C ATOM 1369 CD1 LEU A 88
5.169 59.984 26.135 1.00 0.12 C ATOM 1370 CD2 LEU A 88 3.893 57.777
26.012 1.00 0.12 C ATOM 1371 H LEU A 88 1.475 61.180 22.722 1.00
0.00 H ATOM 1372 HA LEU A 88 3.945 61.699 24.244 1.00 0.00 H ATOM
1373 1HB LEU A 88 2.285 59.119 24.367 1.00 0.00 H ATOM 1374 2HB LEU
A 88 2.468 60.250 25.711 1.00 0.00 H ATOM 1375 HG LEU A 88 4.824
58.770 24.411 1.00 0.00 H ATOM 1376 1HD1 LEU A 88 6.215 59.895
25.827 1.00 0.00 H ATOM 1377 2HD1 LEU A 88 4.833 61.025 26.171 1.00
0.00 H ATOM 1378 3HD1 LEU A 88 5.148 59.665 27.192 1.00 0.00 H ATOM
1379 1HD2 LEU A 88 4.792 57.191 26.258 1.00 0.00 H ATOM 1380 2HD2
LEU A 88 3.353 57.971 26.954 1.00 0.00 H ATOM 1381 3HD2 LEU A 88
3.238 57.148 25.391 1.00 0.00 H ATOM 1382 N LEU A 89 5.192 60.305
22.535 1.00 0.11 N ATOM 1383 CA LEU A 89 5.817 59.659 21.418 1.00
0.11 C ATOM 1384 C LEU A 89 7.020 58.940 21.934 1.00 0.11 C ATOM
1385 O LEU A 89 7.608 59.330 22.942 1.00 0.11 O ATOM 1386 CB LEU A
89 6.316 60.624 20.325 1.00 0.11 C ATOM 1387 CG LEU A 89 6.996
59.930 19.129 1.00 0.11 C ATOM 1388 CD1 LEU A 89 6.001 59.044
18.356 1.00 0.11 C ATOM 1389 CD2 LEU A 89 7.712 60.949 18.228 1.00
0.11 C ATOM 1390 H LEU A 89 5.789 60.680 23.262 1.00 0.00 H ATOM
1391 HA LEU A 89 5.072 59.108 20.865 1.00 0.00 H ATOM 1392 1HB LEU
A 89 7.013 61.361 20.757 1.00 0.00 H ATOM 1393 2HB LEU A 89 5.451
61.173 19.917 1.00 0.00 H ATOM 1394 HG LEU A 89 7.833 59.325 19.477
1.00 0.00 H ATOM 1395 1HD1 LEU A 89 6.458 58.614 17.450 1.00 0.00 H
ATOM 1396 2HD1 LEU A 89 5.636 58.199 18.955 1.00 0.00 H ATOM 1397
3HD1 LEU A 89 5.127 59.633 18.029 1.00 0.00 H ATOM 1398 1HD2 LEU A
89 8.143 60.354 17.418 1.00 0.00 H ATOM 1399 2HD2 LEU A 89 7.008
61.683 17.815 1.00 0.00 H ATOM 1400 3HD2 LEU A 89 8.510 61.485
18.761 1.00 0.00 H ATOM 1401 N LEU A 90 7.400 57.840 21.259 1.00
0.11 N ATOM 1402 CA LEU A 90 8.597 57.166 21.649 1.00 0.11 C ATOM
1403 C LEU A 90 9.606 57.680 20.677 1.00 0.11 C ATOM 1404 O LEU A
90 9.404 57.600 19.467 1.00 0.11 O ATOM 1405 CB LEU A 90 8.527
55.634 21.510 1.00 0.11 C ATOM 1406 CG LEU A 90 9.818 54.918 21.950
1.00 0.11 C ATOM 1407 CD1 LEU A 90 10.083 55.137 23.448 1.00 0.11 C
ATOM 1408 CD2 LEU A 90 9.793 53.429 21.568 1.00 0.11 C ATOM 1409 H
LEU A 90 7.168 57.724 20.279 1.00 0.00 H ATOM 1410 HA LEU A 90
8.845 57.420 22.688 1.00 0.00 H ATOM 1411 1HB LEU A 90 8.288 55.373
20.463 1.00 0.00 H ATOM 1412 2HB LEU A 90 7.684 55.257 22.117 1.00
0.00 H ATOM 1413 HG LEU A 90 10.652 55.369 21.379 1.00 0.00 H ATOM
1414 1HD1 LEU A 90 11.099 55.509 23.615 1.00 0.00 H ATOM 1415 2HD1
LEU A 90 9.407 55.868 23.914 1.00 0.00 H ATOM 1416 3HD1 LEU A 90
9.922 54.203 24.002 1.00 0.00 H ATOM 1417 1HD2 LEU A 90 10.779
52.972 21.676 1.00 0.00 H ATOM 1418 2HD2 LEU A 90 9.069 52.884
22.192 1.00 0.00 H ATOM 1419 3HD2 LEU A 90 9.493 53.311 20.514 1.00
0.00 H ATOM 1420 N GLN A 91 10.719 58.238 21.185 1.00 0.11 N ATOM
1421 CA GLN A 91 11.640 58.868 20.289 1.00 0.11 C ATOM 1422 C GLN A
91 12.857 58.018 20.152 1.00 0.11 C ATOM 1423 O GLN A 91 13.277
57.346 21.093 1.00 0.11 O ATOM 1424 CB GLN A 91 12.096 60.254
20.782 1.00 0.11 C ATOM 1425 CG GLN A 91 10.956 61.273 20.886 1.00
0.11 C ATOM 1426 CD GLN A 91 11.531 62.582 21.415 1.00 0.11 C ATOM
1427 OE1 GLN A 91 12.410 62.580 22.275 1.00 0.11 O ATOM 1428 NE2
GLN A 91 11.026 63.730 20.890 1.00 0.11 N ATOM 1429 H GLN A 91
10.880 58.341 22.182 1.00 0.00 H ATOM 1430 HA GLN A 91 11.164
59.029 19.308 1.00 0.00 H ATOM 1431 1HB GLN A 91 12.816 60.629
20.042 1.00 0.00 H ATOM 1432 2HB GLN A 91 12.614 60.147 21.748 1.00
0.00 H ATOM 1433 1HG GLN A 91 10.184 60.951 21.607 1.00 0.00 H ATOM
1434 2HG GLN A 91 10.464 61.391 19.910 1.00 0.00 H ATOM 1435 1HE2
GLN A 91 10.469 63.660 20.055 1.00 0.00 H ATOM 1436 2HE2 GLN A 91
11.451 64.600 21.151 1.00 0.00 H ATOM 1437 N ALA A 92 13.435 58.011
18.936 1.00 0.18 N ATOM 1438 CA ALA A 92 14.630 57.261 18.701 1.00
0.18 C ATOM 1439 C ALA A 92 15.533 58.108 17.870 1.00 0.18 C ATOM
1440 O ALA A 92 15.082 58.925 17.072 1.00 0.18 O ATOM 1441 CB ALA A
92 14.397 55.956 17.923 1.00 0.18 C ATOM 1442 H ALA A 92 13.116
58.559 18.152 1.00 0.00 H ATOM 1443 HA ALA A 92 15.098 56.977
19.650 1.00 0.00 H ATOM 1444 1HB ALA A 92 15.351 55.416 17.814 1.00
0.00 H ATOM 1445 2HB ALA A 92 13.693 55.304 18.463 1.00 0.00 H ATOM
1446 3HB ALA A 92 13.990 56.146 16.918 1.00 0.00 H ATOM 1447 N SER
A 93 16.852 57.959 18.076 1.00 0.25 N ATOM 1448 CA SER A 93 17.796
58.710 17.309 1.00 0.25 C ATOM 1449 C SER A 93 17.756 58.227 15.893
1.00 0.25 C ATOM 1450 O SER A 93 17.703 59.024 14.957 1.00 0.25 O
ATOM 1451 CB SER A 93 19.230 58.542 17.826 1.00 0.25 C ATOM 1452 OG
SER A 93 20.123 59.308 17.034 1.00 0.25 O ATOM 1453 H SER A 93
17.208 57.332 18.779 1.00 0.00 H ATOM 1454 HA SER A 93 17.535
59.779 17.322 1.00 0.00 H ATOM 1455 1HB SER A 93 19.526 57.478
17.807 1.00 0.00 H ATOM 1456 2HB SER A 93 19.278 58.881 18.878 1.00
0.00 H ATOM 1457 HG SER A 93 21.022 59.117 17.333 1.00 0.00 H ATOM
1458 N ALA A 94 17.769 56.893 15.694 1.00 0.19 N ATOM 1459 CA ALA A
94 17.777 56.384 14.351 1.00 0.19 C ATOM 1460 C ALA A 94 16.919
55.161 14.290 1.00 0.19 C ATOM 1461 O ALA A 94 16.764 54.435 15.271
1.00 0.19 O ATOM 1462 CB ALA A 94 19.179 55.986 13.860 1.00 0.19 C
ATOM 1463 H ALA A 94 17.675 56.216 16.429 1.00 0.00 H ATOM 1464 HA
ALA A 94 17.357 57.141 13.668 1.00 0.00 H ATOM 1465 1HB ALA A 94
19.119 55.626 12.821 1.00 0.00 H ATOM 1466 2HB ALA A 94 19.858
56.852 13.885 1.00 0.00 H ATOM 1467 3HB ALA A 94 19.610 55.186
14.481 1.00 0.00 H ATOM 1468 N GLU A 95 16.301 54.943 13.114 1.00
0.12 N ATOM 1469 CA GLU A 95 15.454 53.816 12.861 1.00 0.12 C ATOM
1470 C GLU A 95 16.282 52.569 12.802 1.00 0.12 C ATOM 1471 O GLU A
95 15.920 51.545 13.378 1.00 0.12 O ATOM 1472 CB GLU A 95 14.711
53.966 11.522 1.00 0.12 C ATOM 1473 CG GLU A 95 13.753 55.164
11.506 1.00 0.12 C ATOM 1474 CD GLU A 95 13.312 55.426 10.073 1.00
0.12 C ATOM 1475 OE1 GLU A 95 13.538 54.538 9.208 1.00 0.12 O ATOM
1476 OE2 GLU A 95 12.742 56.522 9.826 1.00 0.12 O1- ATOM 1477 H GLU
A 95 16.317 55.628 12.375 1.00 0.00 H ATOM 1478 HA GLU A 95 14.723
53.702 13.677 1.00 0.00 H ATOM 1479 1HB GLU A 95 14.147 53.030
11.359 1.00 0.00 H ATOM 1480 2HB GLU A 95 15.448 54.046 10.704 1.00
0.00 H ATOM 1481 1HG GLU A 95 14.200 56.089 11.906 1.00 0.00 H ATOM
1482 2HG GLU A 95 12.869 54.967 12.134 1.00 0.00 H ATOM 1483 N VAL
A 96 17.436 52.630 12.110 1.00 0.11 N ATOM 1484 CA VAL A 96 18.234
51.449 11.956 1.00 0.11 C ATOM 1485 C VAL A 96 19.504 51.637 12.709
1.00 0.11 C ATOM 1486 O VAL A 96 20.025 52.747 12.813 1.00
0.11 O ATOM 1487 CB VAL A 96 18.599 51.162 10.531 1.00 0.11 C ATOM
1488 CG1 VAL A 96 19.514 49.924 10.495 1.00 0.11 C ATOM 1489 CG2
VAL A 96 17.299 51.002 9.726 1.00 0.11 C ATOM 1490 H VAL A 96
17.805 53.489 11.747 1.00 0.00 H ATOM 1491 HA VAL A 96 17.676
50.587 12.332 1.00 0.00 H ATOM 1492 HB VAL A 96 19.167 52.009
10.104 1.00 0.00 H ATOM 1493 1HG1 VAL A 96 19.610 49.588 9.448 1.00
0.00 H ATOM 1494 2HG1 VAL A 96 20.517 50.203 10.851 1.00 0.00 H
ATOM 1495 3HG1 VAL A 96 19.099 49.089 11.077 1.00 0.00 H ATOM 1496
1HG2 VAL A 96 17.491 50.648 8.699 1.00 0.00 H ATOM 1497 2HG2 VAL A
96 16.617 50.282 10.198 1.00 0.00 H ATOM 1498 3HG2 VAL A 96 16.754
51.957 9.632 1.00 0.00 H ATOM 1499 N VAL A 97 20.028 50.531 13.268
1.00 0.10 N ATOM 1500 CA VAL A 97 21.230 50.600 14.039 1.00 0.10 C
ATOM 1501 C VAL A 97 22.100 49.467 13.620 1.00 0.10 C ATOM 1502 O
VAL A 97 21.654 48.534 12.957 1.00 0.10 O ATOM 1503 CB VAL A 97
20.992 50.432 15.511 1.00 0.10 C ATOM 1504 CG1 VAL A 97 20.128
51.603 16.004 1.00 0.10 C ATOM 1505 CG2 VAL A 97 20.363 49.050
15.752 1.00 0.10 C ATOM 1506 H VAL A 97 19.530 49.654 13.277 1.00
0.00 H ATOM 1507 HA VAL A 97 21.758 51.533 13.789 1.00 0.00 H ATOM
1508 HB VAL A 97 21.926 50.382 16.060 1.00 0.00 H ATOM 1509 1HG1
VAL A 97 20.116 51.663 17.104 1.00 0.00 H ATOM 1510 2HG1 VAL A 97
20.458 52.583 15.626 1.00 0.00 H ATOM 1511 3HG1 VAL A 97 19.080
51.481 15.680 1.00 0.00 H ATOM 1512 1HG2 VAL A 97 20.214 48.890
16.835 1.00 0.00 H ATOM 1513 2HG2 VAL A 97 19.366 48.957 15.298
1.00 0.00 H ATOM 1514 3HG2 VAL A 97 21.003 48.221 15.413 1.00 0.00
H ATOM 1515 N MET A 98 23.386 49.536 14.004 1.00 0.12 N ATOM 1516
CA MET A 98 24.315 48.497 13.688 1.00 0.12 C ATOM 1517 C MET A 98
24.355 47.640 14.909 1.00 0.12 C ATOM 1518 O MET A 98 24.093 48.117
16.012 1.00 0.12 O ATOM 1519 CB MET A 98 25.737 49.029 13.442 1.00
0.12 C ATOM 1520 CG MET A 98 25.810 50.033 12.286 1.00 0.12 C ATOM
1521 SD MET A 98 25.466 49.342 10.639 1.00 0.12 S ATOM 1522 CE MET
A 98 27.170 48.804 10.325 1.00 0.12 C ATOM 1523 H MET A 98 23.734
50.300 14.559 1.00 0.00 H ATOM 1524 HA MET A 98 24.011 47.939
12.813 1.00 0.00 H ATOM 1525 1HB MET A 98 26.406 48.172 13.257 1.00
0.00 H ATOM 1526 2HB MET A 98 26.107 49.527 14.356 1.00 0.00 H ATOM
1527 1HG MET A 98 26.805 50.510 12.241 1.00 0.00 H ATOM 1528 2HG
MET A 98 25.093 50.856 12.444 1.00 0.00 H ATOM 1529 1HE MET A 98
27.192 48.311 9.342 1.00 0.00 H ATOM 1530 2HE MET A 98 27.854
49.665 10.300 1.00 0.00 H ATOM 1531 3HE MET A 98 27.497 48.081
11.086 1.00 0.00 H ATOM 1532 N GLU A 99 24.653 46.339 14.755 1.00
0.10 N ATOM 1533 CA GLU A 99 24.662 45.530 15.936 1.00 0.10 C ATOM
1534 C GLU A 99 25.806 45.976 16.779 1.00 0.10 C ATOM 1535 O GLU A
99 26.866 46.341 16.272 1.00 0.10 O ATOM 1536 CB GLU A 99 24.838
44.022 15.682 1.00 0.10 C ATOM 1537 CG GLU A 99 24.757 43.196
16.970 1.00 0.10 C ATOM 1538 CD GLU A 99 24.956 41.726 16.629 1.00
0.10 C ATOM 1539 OE1 GLU A 99 24.323 41.247 15.652 1.00 0.10 O ATOM
1540 OE2 GLU A 99 25.752 41.063 17.347 1.00 0.10 O1- ATOM 1541 H
GLU A 99 24.979 45.929 13.900 1.00 0.00 H ATOM 1542 HA GLU A 99
23.696 45.668 16.459 1.00 0.00 H ATOM 1543 1HB GLU A 99 25.788
43.861 15.155 1.00 0.00 H ATOM 1544 2HB GLU A 99 23.975 43.700
15.117 1.00 0.00 H ATOM 1545 1HG GLU A 99 23.715 43.288 17.265 1.00
0.00 H ATOM 1546 2HG GLU A 99 25.443 43.481 17.776 1.00 0.00 H ATOM
1547 N GLY A 100 25.599 45.973 18.108 1.00 0.20 N ATOM 1548 CA GLY
A 100 26.641 46.338 19.014 1.00 0.20 C ATOM 1549 C GLY A 100 26.474
47.770 19.396 1.00 0.20 C ATOM 1550 O GLY A 100 27.034 48.210
20.399 1.00 0.20 O ATOM 1551 H GLY A 100 24.793 45.476 18.493 1.00
0.00 H ATOM 1552 1HA GLY A 100 27.635 46.198 18.562 1.00 0.00 H
ATOM 1553 2HA GLY A 100 26.586 45.711 19.915 1.00 0.00 H ATOM 1554
N GLN A 101 25.696 48.551 18.624 1.00 0.50 N ATOM 1555 CA GLN A 101
25.580 49.916 19.038 1.00 0.50 C ATOM 1556 C GLN A 101 24.520
50.006 20.078 1.00 0.50 C ATOM 1557 O GLN A 101 23.614 49.177
20.161 1.00 0.50 O ATOM 1558 CB GLN A 101 25.311 50.943 17.920 1.00
0.50 C ATOM 1559 CG GLN A 101 23.985 50.816 17.175 1.00 0.50 C ATOM
1560 CD GLN A 101 23.925 52.009 16.224 1.00 0.50 C ATOM 1561 OE1
GLN A 101 22.862 52.418 15.763 1.00 0.50 O ATOM 1562 NE2 GLN A 101
25.114 52.601 15.932 1.00 0.50 N ATOM 1563 H GLN A 101 25.186
48.208 17.818 1.00 0.00 H ATOM 1564 HA GLN A 101 26.589 50.219
19.360 1.00 0.00 H ATOM 1565 1HB GLN A 101 26.170 50.832 17.236
1.00 0.00 H ATOM 1566 2HB GLN A 101 25.362 51.936 18.402 1.00 0.00
H ATOM 1567 1HG GLN A 101 23.127 50.886 17.861 1.00 0.00 H ATOM
1568 2HG GLN A 101 23.855 50.016 16.515 1.00 0.00 H ATOM 1569 1HE2
GLN A 101 25.979 52.314 16.347 1.00 0.00 H ATOM 1570 2HE2 GLN A 101
25.070 53.427 15.358 1.00 0.00 H ATOM 1571 N PRO A 102 24.671
50.987 20.918 1.00 0.57 N ATOM 1572 CA PRO A 102 23.702 51.170
21.956 1.00 0.57 C ATOM 1573 C PRO A 102 22.464 51.776 21.396 1.00
0.57 C ATOM 1574 O PRO A 102 22.552 52.542 20.440 1.00 0.57 O ATOM
1575 CB PRO A 102 24.375 52.030 23.023 1.00 0.57 C ATOM 1576 CG PRO
A 102 25.870 51.719 22.846 1.00 0.57 C ATOM 1577 CD PRO A 102
26.007 51.366 21.355 1.00 0.57 C ATOM 1578 HA PRO A 102 23.501
50.183 22.400 1.00 0.00 H ATOM 1579 1HB PRO A 102 23.985 51.835
24.034 1.00 0.00 H ATOM 1580 2HB PRO A 102 24.196 53.099 22.815
1.00 0.00 H ATOM 1581 1HG PRO A 102 26.136 50.844 23.462 1.00 0.00
H ATOM 1582 2HG PRO A 102 26.539 52.537 23.155 1.00 0.00 H ATOM
1583 1HD PRO A 102 26.352 52.231 20.768 1.00 0.00 H ATOM 1584 2HD
PRO A 102 26.737 50.556 21.257 1.00 0.00 H ATOM 1585 N LEU A 103
21.299 51.440 21.973 1.00 0.26 N ATOM 1586 CA LEU A 103 20.081
52.025 21.517 1.00 0.26 C ATOM 1587 C LEU A 103 19.597 52.884
22.628 1.00 0.26 C ATOM 1588 O LEU A 103 19.568 52.462 23.782 1.00
0.26 O ATOM 1589 CB LEU A 103 18.971 51.003 21.213 1.00 0.26 C ATOM
1590 CG LEU A 103 17.661 51.649 20.720 1.00 0.26 C ATOM 1591 CD1
LEU A 103 17.856 52.350 19.366 1.00 0.26 C ATOM 1592 CD2 LEU A 103
16.509 50.631 20.709 1.00 0.26 C ATOM 1593 H LEU A 103 21.252
50.742 22.706 1.00 0.00 H ATOM 1594 HA LEU A 103 20.277 52.609
20.607 1.00 0.00 H ATOM 1595 1HB LEU A 103 18.745 50.444 22.129
1.00 0.00 H ATOM 1596 2HB LEU A 103 19.330 50.271 20.467 1.00 0.00
H ATOM 1597 HG LEU A 103 17.358 52.425 21.447 1.00 0.00 H ATOM 1598
1HD1 LEU A 103 16.913 52.798 19.010 1.00 0.00 H ATOM 1599 2HD1 LEU
A 103 18.597 53.162 19.405 1.00 0.00 H ATOM 1600 3HD1 LEU A 103
18.182 51.630 18.598 1.00 0.00 H ATOM 1601 1HD2 LEU A 103 15.604
51.038 20.237 1.00 0.00 H ATOM 1602 2HD2 LEU A 103 16.779 49.714
20.160 1.00 0.00 H ATOM 1603 3HD2 LEU A 103 16.227 50.355 21.735
1.00 0.00 H ATOM 1604 N PHE A 104 19.234 54.137 22.312 1.00 0.08 N
ATOM 1605 CA PHE A 104 18.730 54.987 23.344 1.00 0.08 C ATOM 1606 C
PHE A 104 17.343 55.343 22.936 1.00 0.08 C ATOM 1607 O PHE A 104
17.099 55.705 21.785 1.00 0.08 O ATOM 1608 CB PHE A 104 19.527
56.291 23.513 1.00 0.08 C ATOM 1609 CG PHE A 104 18.986 57.015
24.699 1.00 0.08 C ATOM 1610 CD1 PHE A 104 19.376 56.664 25.972
1.00 0.08 C ATOM 1611 CD2 PHE A 104 18.097 58.052 24.540 1.00 0.08
C ATOM 1612 CE1 PHE A 104 18.881 57.333 27.066 1.00 0.08 C ATOM
1613 CE2 PHE A 104 17.597 58.725 25.630 1.00 0.08 C ATOM 1614 CZ
PHE A 104 17.990 58.364 26.896 1.00 0.08 C ATOM 1615 H PHE A 104
19.154 54.483 21.371 1.00 0.00 H ATOM 1616 HA PHE A 104 18.727
54.463 24.309 1.00 0.00 H ATOM 1617 1HB PHE A 104 19.477 56.897
22.596 1.00 0.00 H ATOM 1618 2HB PHE A 104 20.592 56.046 23.663
1.00 0.00 H ATOM 1619 HD1 PHE A 104 20.097 55.863 26.109 1.00 0.00
H ATOM 1620 HD2 PHE A 104 18.020 58.419 23.527 1.00 0.00 H ATOM
1621 HE1 PHE A 104 19.224 57.065 28.062 1.00 0.00 H ATOM 1622 HE2
PHE A 104 16.936 59.563 25.591 1.00 0.00 H ATOM 1623 HZ PHE A 104
17.766 59.003 27.735 1.00 0.00 H ATOM 1624 N LEU A 105 16.385
55.216 23.872 1.00 0.10 N ATOM 1625 CA LEU A 105 15.028 55.541
23.562 1.00 0.10 C ATOM 1626 C LEU A 105 14.558 56.470 24.624 1.00
0.10 C ATOM 1627 O LEU A 105 15.108 56.504 25.724 1.00 0.10 O ATOM
1628 CB LEU A 105 14.079 54.330 23.569 1.00 0.10 C ATOM 1629 CG LEU
A 105 14.388 53.284 22.481 1.00 0.10 C ATOM 1630 CD1 LEU A 105
13.388 52.118 22.534 1.00 0.10 C ATOM 1631 CD2 LEU A 105 14.485
53.930 21.090 1.00 0.10 C ATOM 1632 H LEU A 105 16.573 54.928
24.828 1.00 0.00 H ATOM 1633 HA LEU A 105 14.968 56.061 22.597 1.00
0.00 H ATOM 1634 1HB LEU A 105 13.123 54.780 23.234 1.00 0.00 H
ATOM 1635 2HB LEU A 105 13.791 53.897 24.481 1.00 0.00 H ATOM 1636
HG LEU A 105 15.382 52.848 22.697 1.00 0.00 H ATOM 1637 1HD1 LEU A
105 13.415 51.501 21.622 1.00 0.00 H ATOM 1638 2HD1 LEU A 105
13.614 51.452 23.383 1.00 0.00 H ATOM 1639 3HD1 LEU A 105 12.364
52.474 22.682 1.00 0.00 H ATOM 1640 1HD2 LEU A 105 14.787 53.185
20.341 1.00 0.00 H ATOM 1641 2HD2 LEU A 105 13.499 54.316 20.781
1.00 0.00 H ATOM 1642 3HD2 LEU A 105 15.189 54.755 20.996 1.00 0.00
H ATOM 1643 N ARG A 106 13.530 57.274 24.307 1.00 0.15 N ATOM 1644
CA ARG A 106 13.059 58.210 25.276 1.00 0.15 C ATOM 1645 C ARG A 106
11.579 58.303 25.130 1.00 0.15 C ATOM 1646 O ARG A 106 11.049
58.285 24.020 1.00 0.15 O ATOM 1647 CB ARG A 106 13.663 59.604
25.034 1.00 0.15 C ATOM 1648 CG ARG A 106 13.241 60.704 26.004 1.00
0.15 C ATOM 1649 CD ARG A 106 14.061 61.978 25.787 1.00 0.15 C ATOM
1650 NE ARG A 106 13.541 63.034 26.698 1.00 0.15 N1+ ATOM 1651 CZ
ARG A 106 12.993 64.164 26.169 1.00 0.15 C ATOM 1652 NH1 ARG A 106
12.935 64.310 24.813 1.00 0.15 N ATOM 1653 NH2 ARG A 106 12.531
65.148 26.995 1.00 0.15 N ATOM 1654 H ARG A 106 13.091 57.282
23.397 1.00 0.00 H ATOM 1655 HA ARG A 106 13.331 57.888 26.288 1.00
0.00 H ATOM 1656 1HB ARG A 106 13.453 59.931 24.002 1.00 0.00 H
ATOM 1657 2HB ARG A 106 14.740 59.440 25.151 1.00 0.00 H ATOM 1658
1HG ARG A 106 13.146 60.420 27.059 1.00 0.00 H ATOM 1659 2HG ARG A
106 12.200 60.978 25.736 1.00 0.00 H ATOM 1660 1HD ARG A 106 13.950
62.234 24.738 1.00 0.00 H ATOM 1661 2HD ARG A 106 15.136 61.855
25.994 1.00 0.00 H ATOM 1662 HE ARG A 106 13.936 63.151 27.606 1.00
0.00 H ATOM 1663 1HH1 ARG A 106 12.969 63.518 24.200 1.00 0.00 H
ATOM 1664 2HH1 ARG A 106 12.383 65.056 24.442 1.00 0.00 H ATOM 1665
1HH2 ARG A 106 12.175 66.008 26.638 1.00 0.00 H ATOM 1666 2HH2 ARG
A 106 12.481 65.003 27.979 1.00 0.00 H ATOM 1667 N CYS A 107 10.862
58.384 26.266 1.00 0.16 N ATOM 1668 CA CYS A 107 9.446 58.560
26.188 1.00 0.16 C ATOM 1669 C CYS A 107 9.261 60.020 26.416 1.00
0.16 C ATOM 1670 O CYS A 107 9.650 60.546 27.458 1.00 0.16 O ATOM
1671 CB CYS A 107 8.663 57.792 27.268 1.00 0.16 C ATOM 1672 SG CYS
A 107 9.006 56.009 27.207 1.00 0.16 S ATOM 1673 H CYS A 107 11.264
58.413 27.191 1.00 0.00 H ATOM 1674 HA CYS A 107 9.063 58.219
25.214 1.00 0.00 H ATOM 1675 1HB CYS A 107 7.591 57.974 27.085 1.00
0.00 H ATOM 1676 2HB CYS A 107 8.887 58.155 28.282 1.00 0.00 H ATOM
1677 N HIS A 108 8.681 60.725 25.429 1.00 0.11 N ATOM 1678 CA HIS A
108 8.593 62.147 25.557 1.00 0.11 C ATOM 1679 C HIS A 108 7.159
62.550 25.545 1.00 0.11 C ATOM 1680 O HIS A 108 6.360 62.037 24.763
1.00 0.11 O ATOM 1681 CB HIS A 108 9.321 62.875 24.412 1.00 0.11 C
ATOM 1682 CG HIS A 108 9.314 64.372 24.517 1.00 0.11 C ATOM 1683
ND1 HIS A 108 8.352 65.173 23.946 1.00 0.11 N ATOM 1684 CD2 HIS A
108 10.189 65.217 25.126 1.00 0.11 C ATOM 1685 CE1 HIS A 108 8.693
66.456 24.231 1.00 0.11 C ATOM 1686 NE2 HIS A 108 9.799 66.533
24.946 1.00 0.11 N ATOM 1687 H HIS A 108 8.344 60.317 24.563 1.00
0.00 H ATOM 1688 HA HIS A 108 9.067 62.476 26.494 1.00 0.00 H ATOM
1689 1HB HIS A 108 8.903 62.553 23.443 1.00 0.00 H ATOM 1690 2HB
HIS A 108 10.372 62.547 24.407 1.00 0.00 H ATOM 1691 HD2 HIS A 108
10.626 64.879 26.029 1.00 0.00 H ATOM 1692 HE1 HIS A 108 7.908
67.175 24.152 1.00 0.00 H ATOM 1693 HE2 HIS A 108 9.908 67.286
25.608 1.00 0.00 H ATOM 1694 N GLY A 109 6.805 63.499 26.433 1.00
0.09 N ATOM 1695 CA GLY A 109 5.456 63.967 26.515 1.00 0.09 C ATOM
1696 C GLY A 109 5.417 65.310 25.871 1.00 0.09 C ATOM 1697 O GLY A
109 6.414 66.029 25.839 1.00 0.09 O ATOM 1698 H GLY A 109 7.478
64.019 26.971 1.00 0.00 H ATOM 1699 1HA GLY A 109 5.161 64.080
27.574 1.00 0.00 H ATOM 1700 2HA GLY A 109 4.765 63.247 26.058 1.00
0.00 H ATOM 1701 N TRP A 110 4.241 65.682 25.339 1.00 0.32 N ATOM
1702 CA TRP A 110 4.097 66.934 24.665 1.00 0.32 C ATOM 1703 C TRP A
110 4.162 68.019 25.691 1.00 0.32 C ATOM 1704 O TRP A 110 3.707
67.858 26.822 1.00 0.32 O ATOM 1705 CB TRP A 110 2.767 67.026
23.890 1.00 0.32 C ATOM 1706 CG TRP A 110 2.534 68.315 23.142 1.00
0.32 C ATOM 1707 CD1 TRP A 110 3.146 68.796 22.021 1.00 0.32 C ATOM
1708 CD2 TRP A 110 1.525 69.270 23.495 1.00 0.32 C ATOM 1709 NE1
TRP A 110 2.583 69.997 21.657 1.00 0.32 N ATOM 1710 CE2 TRP A 110
1.580 70.298 22.553 1.00 0.32 C ATOM 1711 CE3 TRP A 110 0.621
69.288 24.517 1.00 0.32 C ATOM 1712 CZ2 TRP A 110 0.729 71.364
22.620 1.00 0.32 C ATOM 1713 CZ3 TRP A 110 -0.236 70.362 24.583
1.00 0.32 C ATOM 1714 CH2 TRP A 110 -0.183 71.380 23.653 1.00 0.32
C ATOM 1715 H TRP A 110 3.501 64.994 25.214 1.00 0.00 H ATOM 1716
HA TRP A 110 4.922 67.038 23.933 1.00 0.00 H ATOM 1717 1HB TRP A
110 1.929 66.826 24.573 1.00 0.00 H ATOM 1718 2HB TRP A 110 2.766
66.199 23.167 1.00 0.00 H ATOM 1719 HD1 TRP A 110 4.013 68.408
21.524 1.00 0.00 H ATOM 1720 HE1 TRP A 110 3.077 70.649 21.085 1.00
0.00 H ATOM 1721 HE3 TRP A 110 0.604 68.488 25.237 1.00 0.00 H ATOM
1722 HZ2 TRP A 110 0.771 72.167 21.889 1.00 0.00 H ATOM 1723 HZ3
TRP A 110 -1.037 70.345 25.317 1.00 0.00 H ATOM 1724 HH2 TRP A 110
-0.902 72.196 23.710 1.00 0.00 H ATOM 1725 N ARG A 111 4.775 69.157
25.311 1.00 0.53 N ATOM 1726 CA ARG A 111 4.933 70.280 26.189 1.00
0.53 C ATOM 1727 C ARG A 111 5.683 69.866 27.413 1.00 0.53 C ATOM
1728 O ARG A 111 5.653 70.566 28.425 1.00 0.53 O ATOM 1729 CB ARG A
111 3.620 70.933 26.655 1.00 0.53 C ATOM 1730 CG ARG A 111 3.020
71.896 25.633 1.00 0.53 C ATOM 1731 CD ARG A 111 2.053 72.917
26.245 1.00 0.53 C ATOM 1732 NE ARG A 111 0.754 72.237 26.508 1.00
0.53 N1+ ATOM 1733 CZ ARG A 111 -0.186 72.834 27.299 1.00 0.53 C
ATOM 1734 NH1 ARG A 111 0.095 74.017 27.921 1.00 0.53 N ATOM 1735
NH2 ARG A 111 -1.396 72.233 27.493 1.00 0.53 N ATOM 1736 H ARG A
111 5.186 69.239 24.389 1.00 0.00 H ATOM 1737 HA ARG A 111 5.583
71.018 25.683 1.00 0.00 H ATOM 1738 1HB ARG A 111 3.792 71.524
27.570 1.00 0.00 H ATOM 1739 2HB ARG A 111 2.899 70.159 26.910 1.00
0.00 H ATOM 1740 1HG ARG A 111 2.557 71.368 24.791 1.00 0.00 H ATOM
1741 2HG ARG A 111 3.855 72.472 25.192 1.00 0.00 H ATOM 1742 1HD
ARG A 111 1.871 73.778 25.580 1.00 0.00 H ATOM 1743 2HD ARG A 111
2.462 73.292 27.198 1.00 0.00 H ATOM 1744 HE ARG A 111 0.400 71.687
25.751 1.00 0.00 H ATOM 1745 1HH1 ARG A 111 0.986 74.448 27.837
1.00 0.00 H ATOM 1746 2HH1 ARG A 111 -0.584 74.483 28.480 1.00 0.00
H ATOM 1747 1HH2 ARG A 111 -2.095 72.648 28.070 1.00 0.00 H ATOM
1748 2HH2 ARG A 111 -1.585 71.323 27.140 1.00 0.00 H ATOM 1749 N
ASN A 112 6.402 68.732 27.343 1.00 0.33 N ATOM 1750 CA ASN A 112
7.191 68.280 28.452 1.00 0.33 C ATOM 1751 C ASN A 112 6.360 68.240
29.693 1.00 0.33 C ATOM 1752 O ASN A 112 6.800 68.685 30.754 1.00
0.33 O ATOM 1753 CB ASN A 112 8.409 69.178 28.734 1.00 0.33 C ATOM
1754 CG ASN A 112 9.405 68.984 27.605 1.00 0.33 C ATOM 1755 OD1 ASN
A 112 9.721 67.852 27.241 1.00 0.33 O ATOM 1756 ND2 ASN A 112 9.908
70.110 27.031 1.00 0.33 N ATOM 1757 H ASN A 112 6.362 68.142 26.519
1.00 0.00 H ATOM 1758 HA ASN A 112 7.515 67.243 28.253 1.00 0.00 H
ATOM 1759 1HB ASN A 112 8.936 68.822 29.637 1.00 0.00 H ATOM 1760
2HB ASN A 112 8.129 70.229 28.898 1.00 0.00 H ATOM 1761 1HD2 ASN A
112 9.555 71.013 27.290 1.00 0.00 H ATOM 1762 2HD2 ASN A 112 10.399
70.002 26.155 1.00 0.00 H ATOM 1763 N TRP A 113 5.133 67.695 29.612
1.00 0.13 N ATOM 1764 CA TRP A 113 4.351 67.630 30.808 1.00 0.13 C
ATOM 1765 C TRP A 113 4.945 66.562 31.665 1.00 0.13 C ATOM 1766 O
TRP A 113 5.619 65.657 31.177 1.00 0.13 O ATOM 1767 CB TRP A 113
2.864 67.316 30.572 1.00 0.13 C ATOM 1768 CG TRP A 113 2.109 68.431
29.884 1.00 0.13 C ATOM 1769 CD1 TRP A 113 1.666 68.514 28.595 1.00
0.13 C ATOM 1770 CD2 TRP A 113 1.737 69.663 30.524 1.00 0.13 C ATOM
1771 NE1 TRP A 113 1.030 69.717 28.395 1.00 0.13 N ATOM 1772 CE2
TRP A 113 1.071 70.435 29.574 1.00 0.13 C ATOM 1773 CE3 TRP A 113
1.939 70.117 31.798 1.00 0.13 C
ATOM 1774 CZ2 TRP A 113 0.593 71.676 29.891 1.00 0.13 C ATOM 1775
CZ3 TRP A 113 1.451 71.367 32.110 1.00 0.13 C ATOM 1776 CH2 TRP A
113 0.791 72.133 31.174 1.00 0.13 C ATOM 1777 H TRP A 113 4.706
67.474 28.722 1.00 0.00 H ATOM 1778 HA TRP A 113 4.416 68.602
31.331 1.00 0.00 H ATOM 1779 1HB TRP A 113 2.398 67.120 31.554 1.00
0.00 H ATOM 1780 2HB TRP A 113 2.768 66.376 30.007 1.00 0.00 H ATOM
1781 HD1 TRP A 113 1.720 67.746 27.844 1.00 0.00 H ATOM 1782 HE1
TRP A 113 0.985 70.177 27.511 1.00 0.00 H ATOM 1783 HE3 TRP A 113
2.453 69.524 32.547 1.00 0.00 H ATOM 1784 HZ2 TRP A 113 -0.140
72.215 29.363 1.00 0.00 H ATOM 1785 HZ3 TRP A 113 1.587 71.753
33.118 1.00 0.00 H ATOM 1786 HH2 TRP A 113 0.388 73.096 31.480 1.00
0.00 H ATOM 1787 N ASP A 114 4.712 66.648 32.988 1.00 0.12 N ATOM
1788 CA ASP A 114 5.293 65.702 33.895 1.00 0.12 C ATOM 1789 C ASP A
114 4.813 64.344 33.513 1.00 0.12 C ATOM 1790 O ASP A 114 3.627
64.137 33.263 1.00 0.12 O ATOM 1791 CB ASP A 114 4.874 65.921
35.357 1.00 0.12 C ATOM 1792 CG ASP A 114 5.445 67.250 35.823 1.00
0.12 C ATOM 1793 OD1 ASP A 114 6.688 67.432 35.731 1.00 0.12 O ATOM
1794 OD2 ASP A 114 4.640 68.101 36.285 1.00 0.12 O1- ATOM 1795 H
ASP A 114 4.235 67.413 33.434 1.00 0.00 H ATOM 1796 HA ASP A 114
6.396 65.763 33.822 1.00 0.00 H ATOM 1797 1HB ASP A 114 5.326
65.104 35.943 1.00 0.00 H ATOM 1798 2HB ASP A 114 3.782 65.878
35.482 1.00 0.00 H ATOM 1799 N VAL A 115 5.746 63.378 33.447 1.00
0.21 N ATOM 1800 CA VAL A 115 5.368 62.043 33.098 1.00 0.21 C ATOM
1801 C VAL A 115 5.975 61.133 34.112 1.00 0.21 C ATOM 1802 O VAL A
115 7.072 61.378 34.611 1.00 0.21 O ATOM 1803 CB VAL A 115 5.880
61.603 31.759 1.00 0.21 C ATOM 1804 CG1 VAL A 115 5.413 60.158
31.508 1.00 0.21 C ATOM 1805 CG2 VAL A 115 5.402 62.604 30.694 1.00
0.21 C ATOM 1806 H VAL A 115 6.699 63.523 33.725 1.00 0.00 H ATOM
1807 HA VAL A 115 4.271 61.948 33.117 1.00 0.00 H ATOM 1808 HB VAL
A 115 6.981 61.596 31.744 1.00 0.00 H ATOM 1809 1HG1 VAL A 115
5.622 59.852 30.468 1.00 0.00 H ATOM 1810 2HG1 VAL A 115 5.940
59.432 32.142 1.00 0.00 H ATOM 1811 3HG1 VAL A 115 4.326 60.047
31.656 1.00 0.00 H ATOM 1812 1HG2 VAL A 115 6.242 63.234 30.360
1.00 0.00 H ATOM 1813 2HG2 VAL A 115 5.022 62.106 29.788 1.00 0.00
H ATOM 1814 3HG2 VAL A 115 4.626 63.295 31.037 1.00 0.00 H ATOM
1815 N TYR A 116 5.249 60.058 34.455 1.00 0.44 N ATOM 1816 CA TYR A
116 5.738 59.110 35.407 1.00 0.44 C ATOM 1817 C TYR A 116 5.192
57.784 34.997 1.00 0.44 C ATOM 1818 O TYR A 116 4.387 57.702 34.070
1.00 0.44 O ATOM 1819 CB TYR A 116 5.271 59.408 36.836 1.00 0.44 C
ATOM 1820 CG TYR A 116 3.794 59.519 36.746 1.00 0.44 C ATOM 1821
CD1 TYR A 116 2.990 58.419 36.891 1.00 0.44 C ATOM 1822 CD2 TYR A
116 3.215 60.735 36.486 1.00 0.44 C ATOM 1823 CE1 TYR A 116 1.624
58.535 36.797 1.00 0.44 C ATOM 1824 CE2 TYR A 116 1.851 60.859
36.391 1.00 0.44 C ATOM 1825 CZ TYR A 116 1.050 59.757 36.548 1.00
0.44 C ATOM 1826 OH TYR A 116 -0.352 59.883 36.451 1.00 0.44 O ATOM
1827 H TYR A 116 4.338 59.869 34.060 1.00 0.00 H ATOM 1828 HA TYR A
116 6.838 59.072 35.343 1.00 0.00 H ATOM 1829 1HB TYR A 116 5.732
60.345 37.186 1.00 0.00 H ATOM 1830 2HB TYR A 116 5.607 58.618
37.523 1.00 0.00 H ATOM 1831 HD1 TYR A 116 3.439 57.467 37.135 1.00
0.00 H ATOM 1832 HD2 TYR A 116 3.838 61.619 36.358 1.00 0.00 H ATOM
1833 HE1 TYR A 116 0.986 57.727 37.108 1.00 0.00 H ATOM 1834 HE2
TYR A 116 1.421 61.836 36.180 1.00 0.00 H ATOM 1835 HH TYR A 116
-0.572 60.683 35.940 1.00 0.00 H ATOM 1836 N LYS A 117 5.625 56.712
35.689 1.00 0.45 N ATOM 1837 CA LYS A 117 5.196 55.380 35.366 1.00
0.45 C ATOM 1838 C LYS A 117 5.361 55.152 33.903 1.00 0.45 C ATOM
1839 O LYS A 117 4.381 54.992 33.177 1.00 0.45 O ATOM 1840 CB LYS A
117 3.732 55.063 35.716 1.00 0.45 C ATOM 1841 CG LYS A 117 3.486
54.831 37.205 1.00 0.45 C ATOM 1842 CD LYS A 117 2.021 54.552
37.540 1.00 0.45 C ATOM 1843 CE LYS A 117 1.803 54.093 38.982 1.00
0.45 C ATOM 1844 NZ LYS A 117 1.648 55.268 39.868 1.00 0.45 N1+
ATOM 1845 H LYS A 117 6.471 56.822 36.234 1.00 0.00 H ATOM 1846 HA
LYS A 117 5.857 54.686 35.905 1.00 0.00 H ATOM 1847 1HB LYS A 117
3.423 54.134 35.202 1.00 0.00 H ATOM 1848 2HB LYS A 117 3.072
55.855 35.321 1.00 0.00 H ATOM 1849 1HG LYS A 117 4.032 55.470
37.906 1.00 0.00 H ATOM 1850 2HG LYS A 117 3.730 53.803 37.280 1.00
0.00 H ATOM 1851 1HD LYS A 117 1.662 53.770 36.846 1.00 0.00 H ATOM
1852 2HD LYS A 117 1.404 55.440 37.399 1.00 0.00 H ATOM 1853 1HE
LYS A 117 2.615 53.456 39.361 1.00 0.00 H ATOM 1854 2HE LYS A 117
0.875 53.505 39.082 1.00 0.00 H ATOM 1855 1HZ LYS A 117 1.542
55.010 40.843 1.00 0.00 H ATOM 1856 2HZ LYS A 117 2.458 55.876
39.832 1.00 0.00 H ATOM 1857 3HZ LYS A 117 0.847 55.842 39.642 1.00
0.00 H ATOM 1858 N VAL A 118 6.621 55.134 33.433 1.00 0.21 N ATOM
1859 CA VAL A 118 6.873 54.949 32.037 1.00 0.21 C ATOM 1860 C VAL A
118 7.212 53.512 31.806 1.00 0.21 C ATOM 1861 O VAL A 118 7.958
52.902 32.569 1.00 0.21 O ATOM 1862 CB VAL A 118 8.032 55.762
31.546 1.00 0.21 C ATOM 1863 CG1 VAL A 118 8.313 55.380 30.088 1.00
0.21 C ATOM 1864 CG2 VAL A 118 7.708 57.251 31.749 1.00 0.21 C ATOM
1865 H VAL A 118 7.436 55.211 34.029 1.00 0.00 H ATOM 1866 HA VAL A
118 5.985 55.278 31.488 1.00 0.00 H ATOM 1867 HB VAL A 118 8.930
55.521 32.142 1.00 0.00 H ATOM 1868 1HG1 VAL A 118 9.125 56.011
29.696 1.00 0.00 H ATOM 1869 2HG1 VAL A 118 8.627 54.336 29.946
1.00 0.00 H ATOM 1870 3HG1 VAL A 118 7.399 55.589 29.526 1.00 0.00
H ATOM 1871 1HG2 VAL A 118 8.495 57.906 31.341 1.00 0.00 H ATOM
1872 2HG2 VAL A 118 6.771 57.514 31.231 1.00 0.00 H ATOM 1873 3HG2
VAL A 118 7.597 57.515 32.814 1.00 0.00 H ATOM 1874 N ILE A 119
6.636 52.922 30.739 1.00 0.09 N ATOM 1875 CA ILE A 119 6.937 51.557
30.434 1.00 0.09 C ATOM 1876 C ILE A 119 7.363 51.496 29.005 1.00
0.09 C ATOM 1877 O ILE A 119 6.814 52.188 28.149 1.00 0.09 O ATOM
1878 CB ILE A 119 5.765 50.634 30.583 1.00 0.09 C ATOM 1879 CG1 ILE
A 119 5.244 50.662 32.028 1.00 0.09 C ATOM 1880 CG2 ILE A 119 6.202
49.239 30.108 1.00 0.09 C ATOM 1881 CD1 ILE A 119 3.887 49.980
32.199 1.00 0.09 C ATOM 1882 H ILE A 119 6.019 53.432 30.114 1.00
0.00 H ATOM 1883 HA ILE A 119 7.753 51.208 31.079 1.00 0.00 H ATOM
1884 HB ILE A 119 4.974 50.986 29.918 1.00 0.00 H ATOM 1885 1HG1
ILE A 119 5.127 51.696 32.388 1.00 0.00 H ATOM 1886 2HG1 ILE A 119
5.962 50.087 32.618 1.00 0.00 H ATOM 1887 1HG2 ILE A 119 5.476
48.458 30.381 1.00 0.00 H ATOM 1888 2HG2 ILE A 119 6.342 49.174
29.021 1.00 0.00 H ATOM 1889 3HG2 ILE A 119 7.135 48.928 30.599
1.00 0.00 H ATOM 1890 1HD1 ILE A 119 3.583 50.024 33.259 1.00 0.00
H ATOM 1891 2HD1 ILE A 119 3.096 50.494 31.635 1.00 0.00 H ATOM
1892 3HD1 ILE A 119 3.917 48.912 31.939 1.00 0.00 H ATOM 1893 N TYR
A 120 8.383 50.666 28.722 1.00 0.09 N ATOM 1894 CA TYR A 120 8.837
50.488 27.377 1.00 0.09 C ATOM 1895 C TYR A 120 8.350 49.159 26.923
1.00 0.09 C ATOM 1896 O TYR A 120 8.418 48.175 27.658 1.00 0.09 O
ATOM 1897 CB TYR A 120 10.367 50.494 27.212 1.00 0.09 C ATOM 1898
CG TYR A 120 10.850 51.903 27.189 1.00 0.09 C ATOM 1899 CD1 TYR A
120 11.051 52.631 28.339 1.00 0.09 C ATOM 1900 CD2 TYR A 120 11.111
52.492 25.973 1.00 0.09 C ATOM 1901 CE1 TYR A 120 11.504 53.929
28.266 1.00 0.09 C ATOM 1902 CE2 TYR A 120 11.563 53.785 25.893
1.00 0.09 C ATOM 1903 CZ TYR A 120 11.761 54.505 27.043 1.00 0.09 C
ATOM 1904 OH TYR A 120 12.226 55.832 26.949 1.00 0.09 O ATOM 1905 H
TYR A 120 8.765 50.046 29.425 1.00 0.00 H ATOM 1906 HA TYR A 120
8.416 51.282 26.738 1.00 0.00 H ATOM 1907 1HB TYR A 120 10.609
49.990 26.261 1.00 0.00 H ATOM 1908 2HB TYR A 120 10.841 49.895
28.003 1.00 0.00 H ATOM 1909 HD1 TYR A 120 10.804 52.180 29.294
1.00 0.00 H ATOM 1910 HD2 TYR A 120 10.959 51.928 25.055 1.00 0.00
H ATOM 1911 HE1 TYR A 120 11.635 54.510 29.175 1.00 0.00 H ATOM
1912 HE2 TYR A 120 11.814 54.215 24.941 1.00 0.00 H ATOM 1913 HH
TYR A 120 11.980 56.270 27.778 1.00 0.00 H ATOM 1914 N TYR A 121
7.816 49.106 25.689 1.00 0.18 N ATOM 1915 CA TYR A 121 7.302 47.867
25.199 1.00 0.18 C ATOM 1916 C TYR A 121 8.013 47.542 23.925 1.00
0.18 C ATOM 1917 O TYR A 121 8.291 48.417 23.108 1.00 0.18 O ATOM
1918 CB TYR A 121 5.803 47.929 24.877 1.00 0.18 C ATOM 1919 CG TYR
A 121 5.083 48.219 26.150 1.00 0.18 C ATOM 1920 CD1 TYR A 121 4.694
47.198 26.987 1.00 0.18 C ATOM 1921 CD2 TYR A 121 4.800 49.517
26.509 1.00 0.18 C ATOM 1922 CE1 TYR A 121 4.028 47.469 28.160 1.00
0.18 C ATOM 1923 CE2 TYR A 121 4.134 49.792 27.679 1.00 0.18 C ATOM
1924 CZ TYR A 121 3.744 48.768 28.506 1.00 0.18 C ATOM 1925 OH TYR
A 121 3.059 49.051 29.707 1.00 0.18 O ATOM 1926 H TYR A 121 7.631
49.920 25.112 1.00 0.00 H ATOM 1927 HA TYR A 121 7.436 47.107
25.959 1.00 0.00 H ATOM 1928 1HB TYR A 121 5.532 46.953 24.447 1.00
0.00 H ATOM 1929 2HB TYR A 121 5.646 48.703 24.116 1.00 0.00 H ATOM
1930 HD1 TYR A 121 4.897 46.165 26.711 1.00 0.00 H ATOM 1931 HD2
TYR A 121 5.098 50.334 25.859 1.00 0.00 H ATOM 1932 HE1 TYR A 121
3.695 46.652 28.797 1.00 0.00 H ATOM 1933 HE2 TYR A 121 4.048
50.841 27.783 1.00 0.00 H ATOM 1934 HH TYR A 121 2.599 49.887
29.539 1.00 0.00 H ATOM 1935 N LYS A 122 8.347 46.249 23.757 1.00
0.28 N ATOM 1936 CA LYS A 122 9.000 45.727 22.598 1.00 0.28 C ATOM
1937 C LYS A 122 8.109 44.630 22.126 1.00 0.28 C ATOM 1938 O LYS A
122 7.986 43.602 22.790 1.00 0.28 O ATOM 1939 CB LYS A 122 10.349
45.062 22.933 1.00 0.28 C ATOM 1940 CG LYS A 122 11.176 44.623
21.722 1.00 0.28 C ATOM 1941 CD LYS A 122 12.535 44.030 22.111 1.00
0.28 C ATOM 1942 CE LYS A 122 13.183 44.715 23.316 1.00 0.28 C ATOM
1943 NZ LYS A 122 14.483 44.075 23.628 1.00 0.28 N1+ ATOM 1944 H
LYS A 122 8.145 45.567 24.483 1.00 0.00 H ATOM 1945 HA LYS A 122
9.164 46.528 21.864 1.00 0.00 H ATOM 1946 1HB LYS A 122 10.242
44.240 23.659 1.00 0.00 H ATOM 1947 2HB LYS A 122 10.988 45.835
23.342 1.00 0.00 H ATOM 1948 1HG LYS A 122 11.311 45.492 21.057
1.00 0.00 H ATOM 1949 2HG LYS A 122 10.623 43.882 21.114 1.00 0.00
H ATOM 1950 1HD LYS A 122 13.201 44.012 21.232 1.00 0.00 H ATOM
1951 2HD LYS A 122 12.369 42.972 22.385 1.00 0.00 H ATOM 1952 1HE
LYS A 122 12.551 44.547 24.190 1.00 0.00 H ATOM 1953 2HE LYS A 122
13.425 45.746 23.185 1.00 0.00 H ATOM 1954 1HZ LYS A 122 14.925
44.473 24.445 1.00 0.00 H ATOM 1955 2HZ LYS A 122 14.393 43.081
23.789 1.00 0.00 H ATOM 1956 3HZ LYS A 122 15.133 44.201 22.860
1.00 0.00 H ATOM 1957 N ASP A 123 7.464 44.826 20.965 1.00 0.20 N
ATOM 1958 CA ASP A 123 6.591 43.826 20.428 1.00 0.20 C ATOM 1959 C
ASP A 123 5.595 43.429 21.470 1.00 0.20 C ATOM 1960 O ASP A 123
5.193 42.269 21.556 1.00 0.20 O ATOM 1961 CB ASP A 123 7.339 42.593
19.901 1.00 0.20 C ATOM 1962 CG ASP A 123 8.044 43.045 18.631 1.00
0.20 C ATOM 1963 OD1 ASP A 123 7.553 44.021 18.001 1.00 0.20 O ATOM
1964 OD2 ASP A 123 9.081 42.430 18.274 1.00 0.20 O1- ATOM 1965 H
ASP A 123 7.666 45.628 20.369 1.00 0.00 H ATOM 1966 HA ASP A 123
5.968 44.289 19.639 1.00 0.00 H ATOM 1967 1HB ASP A 123 6.613
41.815 19.612 1.00 0.00 H ATOM 1968 2HB ASP A 123 8.032 42.140
20.623 1.00 0.00 H ATOM 1969 N GLY A 124 5.173 44.404 22.296 1.00
0.17 N ATOM 1970 CA GLY A 124 4.147 44.159 23.266 1.00 0.17 C ATOM
1971 C GLY A 124 4.739 43.612 24.523 1.00 0.17 C ATOM 1972 O GLY A
124 4.011 43.266 25.454 1.00 0.17 O ATOM 1973 H GLY A 124 5.538
45.337 22.192 1.00 0.00 H ATOM 1974 1HA GLY A 124 3.420 43.428
22.877 1.00 0.00 H ATOM 1975 2HA GLY A 124 3.606 45.080 23.485 1.00
0.00 H ATOM 1976 N GLU A 125 6.076 43.516 24.601 1.00 0.24 N ATOM
1977 CA GLU A 125 6.638 42.987 25.806 1.00 0.24 C ATOM 1978 C GLU A
125 7.229 44.137 26.552 1.00 0.24 C ATOM 1979 O GLU A 125 7.934
44.962 25.980 1.00 0.24 O ATOM 1980 CB GLU A 125 7.747 41.958
25.550 .1.00 0.24 C ATOM 1981 CG GLU A 125 8.099 41.137 26.785 1.00
0.24 C ATOM 1982 CD GLU A 125 9.183 40.146 26.392 1.00 0.24 C ATOM
1983 OE1 GLU A 125 10.013 40.500 25.512 1.00 0.24 O ATOM 1984 OE2
GLU A 125 9.192 39.023 26.962 1.00 0.24 O1- ATOM 1985 H GLU A 125
6.662 43.562 23.773 1.00 0.00 H ATOM 1986 HA GLU A 125 5.870 42.467
26.400 1.00 0.00 H ATOM 1987 1HB GLU A 125 8.638 42.476 25.156 1.00
0.00 H ATOM 1988 2HB GLU A 125 7.408 41.267 24.755 1.00 0.00 H ATOM
1989 1HG GLU A 125 7.225 40.613 27.203 1.00 0.00 H ATOM 1990 2HG
GLU A 125 8.494 41.789 27.582 1.00 0.00 H ATOM 1991 N ALA A 126
6.967 44.237 27.865 1.00 0.26 N ATOM 1992 CA ALA A 126 7.483 45.377
28.563 1.00 0.26 C ATOM 1993 C ALA A 126 8.923 45.129 28.870 1.00
0.26 C ATOM 1994 O ALA A 126 9.257 44.250 29.662 1.00 0.26 O ATOM
1995 CB ALA A 126 6.771 45.654 29.898 1.00 0.26 C ATOM 1996 H ALA A
126 6.357 43.601 28.352 1.00 0.00 H ATOM 1997 HA ALA A 126 7.283
46.254 27.943 1.00 0.00 H ATOM 1998 1HB ALA A 126 7.244 46.526
30.375 1.00 0.00 H ATOM 1999 2HB ALA A 126 5.708 45.881 29.733 1.00
0.00 H ATOM 2000 3HB ALA A 126 6.836 44.803 30.593 1.00 0.00 H ATOM
2001 N LEU A 127 9.819 45.889 28.210 1.00 0.39 N ATOM 2002 CA LEU A
127 11.223 45.746 28.455 1.00 0.39 C ATOM 2003 C LEU A 127 11.504
46.207 29.846 1.00 0.39 C ATOM 2004 O LEU A 127 12.150 45.505
30.622 1.00 0.39 O ATOM 2005 CB LEU A 127 12.082 46.623 27.532 1.00
0.39 C ATOM 2006 CG LEU A 127 11.973 46.250 26.046 1.00 0.39 C ATOM
2007 CD1 LEU A 127 10.541 46.453 25.527 1.00 0.39 C ATOM 2008 CD2
LEU A 127 13.021 47.001 25.210 1.00 0.39 C ATOM 2009 H LEU A 127
9.483 46.608 27.583 1.00 0.00 H ATOM 2010 HA LEU A 127 11.516
44.689 28.359 1.00 0.00 H ATOM 2011 1HB LEU A 127 13.130 46.502
27.866 1.00 0.00 H ATOM 2012 2HB LEU A 127 11.833 47.689 27.665
1.00 0.00 H ATOM 2013 HG LEU A 127 12.195 45.170 26.006 1.00 0.00 H
ATOM 2014 1HD1 LEU A 127 10.536 47.074 24.623 1.00 0.00 H ATOM 2015
2HD1 LEU A 127 10.073 45.481 25.396 1.00 0.00 H ATOM 2016 3HD1 LEU
A 127 9.942 47.094 26.169 1.00 0.00 H ATOM 2017 1HD2 LEU A 127
12.582 46.866 24.252 1.00 0.00 H ATOM 2018 2HD2 LEU A 127 13.035
48.076 25.442 1.00 0.00 H ATOM 2019 3HD2 LEU A 127 14.037 46.592
25.281 1.00 0.00 H ATOM 2020 N LYS A 128 11.008 47.409 30.209 1.00
0.43 N ATOM 2021 CA LYS A 128 11.294 47.881 31.530 1.00 0.43 C ATOM
2022 C LYS A 128 10.216 48.824 31.948 1.00 0.43 C ATOM 2023 O LYS A
128 9.524 49.417 31.122 1.00 0.43 O ATOM 2024 CB LYS A 128 12.614
48.659 31.641 1.00 0.43 C ATOM 2025 CG LYS A 128 12.560 50.028
30.960 1.00 0.43 C ATOM 2026 CD LYS A 128 13.718 50.948 31.350 1.00
0.43 C ATOM 2027 CE LYS A 128 13.540 52.388 30.872 1.00 0.43 C ATOM
2028 NZ LYS A 128 12.447 53.031 31.635 1.00 0.43 N1+ ATOM 2029 H
LYS A 128 10.328 47.889 29.646 1.00 0.00 H ATOM 2030 HA LYS A 128
11.296 47.023 32.227 1.00 0.00 H ATOM 2031 1HB LYS A 128 13.445
48.056 31.235 1.00 0.00 H ATOM 2032 2HB LYS A 128 12.825 48.793
32.717 1.00 0.00 H ATOM 2033 1HG LYS A 128 11.647 50.560 31.271
1.00 0.00 H ATOM 2034 2HG LYS A 128 12.473 49.888 29.880 1.00 0.00
H ATOM 2035 1HD LYS A 128 14.667 50.553 30.950 1.00 0.00 H ATOM
2036 2HD LYS A 128 13.841 50.944 32.449 1.00 0.00 H ATOM 2037 1HE
LYS A 128 13.239 52.423 29.841 1.00 0.00 H ATOM 2038 2HE LYS A 128
14.468 52.924 31.072 1.00 0.00 H ATOM 2039 1HZ LYS A 128 12.368
54.022 31.429 1.00 0.00 H ATOM 2040 2HZ LYS A 128 11.541 52.625
31.442 1.00 0.00 H ATOM 2041 3HZ LYS A 128 12.593 52.977 32.634
1.00 0.00 H ATOM 2042 N TYR A 129 10.043 48.960 33.275 1.00 0.26 N
ATOM 2043 CA TYR A 129 9.095 49.877 33.832 1.00 0.26 C ATOM 2044 C
TYR A 129 9.784 50.604 34.940 1.00 0.26 C ATOM 2045 O TYR A 129
10.405 49.987 35.803 1.00 0.26 O ATOM 2046 CB TYR A 129 7.861
49.183 34.435 1.00 0.26 C ATOM 2047 CG TYR A 129 7.171 50.160
35.325 1.00 0.26 C ATOM 2048 CD1 TYR A 129 6.375 51.165 34.823 1.00
0.26 C ATOM 2049 CD2 TYR A 129 7.327 50.051 36.687 1.00 0.26 C ATOM
2050 CE1 TYR A 129 5.750 52.050 35.674 1.00 0.26 C ATOM 2051 CE2
TYR A 129 6.707 50.930 37.540 1.00 0.26 C ATOM 2052 CZ TYR A 129
5.916 51.931 37.035 1.00 0.26 C ATOM 2053 OH TYR A 129 5.283 52.830
37.916 1.00 0.26 O ATOM 2054 H TYR A 129 10.608 48.473 33.952 1.00
0.00 H ATOM 2055 HA TYR A 129 8.771 50.575 33.049 1.00 0.00 H ATOM
2056 1HB TYR A 129 8.174 48.298 35.013 1.00 0.00 H ATOM 2057 2HB
TYR A 129 7.213 48.793 33.637 1.00 0.00 H ATOM 2058 HD1 TYR A 129
6.455 51.455 33.799 1.00 0.00 H ATOM 2059 HD2 TYR A 129 7.952
49.261 37.097 1.00 0.00 H ATOM 2060 HE1 TYR A 129 5.114 52.806
35.239 1.00 0.00 H ATOM 2061 HE2 TYR A 129 6.841 50.791 38.607 1.00
0.00 H ATOM 2062
HH TYR A 129 5.829 52.879 38.713 1.00 0.00 H ATOM 2063 N TRP A 130
9.712 51.950 34.931 1.00 0.16 N ATOM 2064 CA TRP A 130 10.311
52.685 36.006 1.00 0.16 C ATOM 2065 C TRP A 130 9.437 53.879 36.219
1.00 0.16 C ATOM 2066 O TRP A 130 8.929 54.461 35.261 1.00 0.16 O
ATOM 2067 CB TRP A 130 11.716 53.211 35.683 1.00 0.16 C ATOM 2068
CG TRP A 130 12.467 53.739 36.882 1.00 0.16 C ATOM 2069 CD1 TRP A
130 12.409 54.960 37.486 1.00 0.16 C ATOM 2070 CD2 TRP A 130 13.463
52.984 37.588 1.00 0.16 C ATOM 2071 NE1 TRP A 130 13.299 55.007
38.532 1.00 0.16 N ATOM 2072 CE2 TRP A 130 13.957 53.800 38.603
1.00 0.16 C ATOM 2073 CE3 TRP A 130 13.932 51.715 37.402 1.00 0.16
C ATOM 2074 CZ2 TRP A 130 14.932 53.360 39.452 1.00 0.16 C ATOM
2075 CZ3 TRP A 130 14.913 51.273 38.264 1.00 0.16 C ATOM 2076 CH2
TRP A 130 15.404 52.079 39.270 1.00 0.16 C ATOM 2077 H TRP A 130
9.109 52.460 34.292 1.00 0.00 H ATOM 2078 HA TRP A 130 10.329
52.061 36.916 1.00 0.00 H ATOM 2079 1HB TRP A 130 11.622 53.988
34.909 1.00 0.00 H ATOM 2080 2HB TRP A 130 12.306 52.403 35.220
1.00 0.00 H ATOM 2081 HD1 TRP A 130 11.643 55.612 37.343 1.00 0.00
H ATOM 2082 HE1 TRP A 130 13.577 55.818 39.058 1.00 0.00 H ATOM
2083 HE3 TRP A 130 13.550 51.063 36.623 1.00 0.00 H ATOM 2084 HZ2
TRP A 130 15.318 54.001 40.242 1.00 0.00 H ATOM 2085 HZ3 TRP A 130
15.309 50.266 38.152 1.00 0.00 H ATOM 2086 HH2 TRP A 130 16.179
51.696 39.930 1.00 0.00 H ATOM 2087 N TYR A 131 9.204 54.267 37.487
1.00 0.17 N ATOM 2088 CA TYR A 131 8.351 55.401 37.683 1.00 0.17 C
ATOM 2089 C TYR A 131 8.991 56.631 37.120 1.00 0.17 C ATOM 2090 O
TYR A 131 8.436 57.284 36.238 1.00 0.17 O ATOM 2091 CB TYR A 131
8.087 55.714 39.164 1.00 0.17 C ATOM 2092 CG TYR A 131 7.166 54.693
39.731 1.00 0.17 C ATOM 2093 CD1 TYR A 131 7.617 53.438 40.072 1.00
0.17 C ATOM 2094 CD2 TYR A 131 5.844 55.009 39.937 1.00 0.17 C ATOM
2095 CE1 TYR A 131 6.754 52.508 40.602 1.00 0.17 C ATOM 2096 CE2
TYR A 131 4.977 54.084 40.465 1.00 0.17 C ATOM 2097 CZ TYR A 131
5.433 52.832 40.800 1.00 0.17 C ATOM 2098 OH TYR A 131 4.542 51.882
41.345 1.00 0.17 O ATOM 2099 H TYR A 131 9.634 53.823 38.280 1.00
0.00 H ATOM 2100 HA TYR A 131 7.395 55.233 37.177 1.00 0.00 H ATOM
2101 1HB TYR A 131 7.635 56.719 39.216 1.00 0.00 H ATOM 2102 2HB
TYR A 131 9.022 55.767 39.746 1.00 0.00 H ATOM 2103 HD1 TYR A 131
8.667 53.180 39.973 1.00 0.00 H ATOM 2104 HD2 TYR A 131 5.494
56.012 39.704 1.00 0.00 H ATOM 2105 HE1 TYR A 131 7.138 51.529
40.884 1.00 0.00 H ATOM 2106 HE2 TYR A 131 3.963 54.370 40.710 1.00
0.00 H ATOM 2107 HH TYR A 131 5.048 51.342 41.965 1.00 0.00 H ATOM
2108 N GLU A 132 10.189 56.977 37.630 1.00 0.19 N ATOM 2109 CA GLU
A 132 10.842 58.196 37.249 1.00 0.19 C ATOM 2110 C GLU A 132 11.520
58.139 35.909 1.00 0.19 C ATOM 2111 O GLU A 132 11.501 59.125
35.175 1.00 0.19 O ATOM 2112 CE GLU A 132 11.851 58.705 38.295 1.00
0.19 C ATOM 2113 CG GLU A 132 13.030 57.774 38.565 1.00 0.19 C ATOM
2114 CD GLU A 132 13.838 58.387 39.702 1.00 0.19 C ATOM 2115 OE1
GLU A 132 14.098 59.618 39.651 1.00 0.19 O ATOM 2116 OE2 GLU A 132
14.202 57.630 40.641 1.00 0.19 O1- ATOM 2117 H GLU A 132 10.574
56.510 38.434 1.00 0.00 H ATOM 2118 HA GLU A 132 10.066 58.975
37.149 1.00 0.00 H ATOM 2119 1HB GLU A 132 11.321 58.901 39.245
1.00 0.00 H ATOM 2120 2HB GLU A 132 12.189 59.689 37.919 1.00 0.00
H ATOM 2121 1HG GLU A 132 13.639 57.522 37.692 1.00 0.00 H ATOM
2122 2HG GLU A 132 12.498 56.967 39.059 1.00 0.00 H ATOM 2123 N ASN
A 133 12.116 56.988 35.539 1.00 0.18 N ATOM 2124 CA ASN A 133
12.974 56.963 34.382 1.00 0.18 C ATOM 2125 C ASN A 133 12.209
57.009 33.098 1.00 0.18 C ATOM 2126 O ASN A 133 11.487 56.080
32.738 1.00 0.18 O ATOM 2127 CB ASN A 133 13.907 55.737 34.320 1.00
0.18 C ATOM 2128 CG ASN A 133 14.988 56.023 33.284 1.00 0.18 C ATOM
2129 OD1 ASN A 133 14.893 56.984 32.522 1.00 0.18 O ATOM 2130 ND2
ASN A 133 16.041 55.162 33.248 1.00 0.18 N ATOM 2131 H ASN A 133
12.152 56.184 36.126 1.00 0.00 H ATOM 2132 HA ASN A 133 13.641
57.843 34.482 1.00 0.00 H ATOM 2133 1HB ASN A 133 13.387 54.810
34.048 1.00 0.00 H ATOM 2134 2HB ASN A 133 14.388 55.588 35.302
1.00 0.00 H ATOM 2135 1HD2 ASN A 133 16.149 54.411 33.904 1.00 0.00
H ATOM 2136 2HD2 ASN A 133 16.735 55.326 32.538 1.00 0.00 H ATOM
2137 N HIS A 134 12.358 58.148 32.393 1.00 0.16 N ATOM 2138 CA HIS
A 134 11.782 58.440 31.111 1.00 0.16 C ATOM 2139 C HIS A 134 12.510
57.713 30.020 1.00 0.16 C ATOM 2140 O HIS A 134 11.908 57.336
29.016 1.00 0.16 O ATOM 2141 CB HIS A 134 11.845 59.939 30.781 1.00
0.16 C ATOM 2142 CG HIS A 134 11.133 60.773 31.803 1.00 0.16 C ATOM
2143 ND1 HIS A 134 9.767 60.954 31.837 1.00 0.16 N ATOM 2144 CD2
HIS A 134 11.627 61.476 32.858 1.00 0.16 C ATOM 2145 CE1 HIS A 134
9.506 61.751 32.903 1.00 0.16 C ATOM 2146 NE2 HIS A 134 10.603
62.094 33.554 1.00 0.16 N ATOM 2147 H HIS A 134 12.816 58.920
32.852 1.00 0.00 H ATOM 2148 HA HIS A 134 10.736 58.098 31.094 1.00
0.00 H ATOM 2149 1HB HIS A 134 11.406 60.080 29.778 1.00 0.00 H
ATOM 2150 2HB HIS A 134 12.890 60.276 30.715 1.00 0.00 H ATOM 2151
HD2 HIS A 134 12.657 61.578 33.175 1.00 0.00 H ATOM 2152 HE1 HIS A
134 8.543 62.184 33.088 1.00 0.00 H ATOM 2153 HE2 HIS A 134 10.667
62.639 34.389 1.00 0.00 H ATOM 2154 N ASN A 135 13.835 57.507
30.179 1.00 0.14 N ATOM 2155 CA ASN A 135 14.631 56.982 29.100 1.00
0.14 C ATOM 2156 C ASN A 135 14.941 55.534 29.306 1.00 0.14 C ATOM
2157 O ASN A 135 14.867 55.010 30.416 1.00 0.14 O ATOM 2158 CB ASN
A 135 15.986 57.690 28.963 1.00 0.14 C ATOM 2159 CG ASN A 135
15.720 59.156 28.665 1.00 0.14 C ATOM 2160 OD1 ASN A 135 15.032
59.498 27.704 1.00 0.14 O ATOM 2161 ND2 ASN A 135 16.270 60.053
29.528 1.00 0.14 N ATOM 2162 H ASN A 135 14.277 57.581 31.090 1.00
0.00 H ATOM 2163 HA ASN A 135 14.091 57.126 28.156 1.00 0.00 H ATOM
2164 1HB ASN A 135 16.465 57.199 28.112 1.00 0.00 H ATOM 2165 2HB
ASN A 135 16.609 57.530 29.857 1.00 0.00 H ATOM 2166 1HD2 ASN A 135
16.809 59.763 30.324 1.00 0.00 H ATOM 2167 2HD2 ASN A 135 16.088
61.027 29.364 1.00 0.00 H ATOM 2168 N ILE A 136 15.270 54.846
28.190 1.00 0.19 N ATOM 2169 CA ILE A 136 15.665 53.467 28.207 1.00
0.19 C ATOM 2170 C ILE A 136 16.831 53.341 27.279 1.00 0.19 C ATOM
2171 O ILE A 136 16.909 54.042 26.272 1.00 0.19 O ATOM 2172 CB ILE
A 136 14.612 52.529 27.694 1.00 0.19 C ATOM 2173 CG1 ILE A 136
15.014 51.070 27.966 1.00 0.19 C ATOM 2174 CG2 ILE A 136 14.381
52.844 26.207 1.00 0.19 C ATOM 2175 CD1 ILE A 136 13.874 50.077
27.751 1.00 0.19 C ATOM 2176 H ILE A 136 15.312 55.307 27.283 1.00
0.00 H ATOM 2177 HA ILE A 136 15.976 53.214 29.234 1.00 0.00 H ATOM
2178 HB ILE A 136 13.653 52.762 28.141 1.00 0.00 H ATOM 2179 1HG1
ILE A 136 15.391 50.970 28.996 1.00 0.00 H ATOM 2180 2HG1 ILE A 136
15.848 50.770 27.308 1.00 0.00 H ATOM 2181 1HG2 ILE A 136 13.544
52.256 25.812 1.00 0.00 H ATOM 2182 2HG2 ILE A 136 14.172 53.918
26.193 1.00 0.00 H ATOM 2183 3HG2 ILE A 136 15.231 52.583 25.560
1.00 0.00 H ATOM 2184 1HD1 ILE A 136 14.060 49.114 28.250 1.00 0.00
H ATOM 2185 2HD1 ILE A 136 12.927 50.491 28.101 1.00 0.00 H ATOM
2186 3HD1 ILE A 136 13.745 49.876 26.675 1.00 0.00 H ATOM 2187 N
SER A 137 17.788 52.452 27.604 1.00 0.24 N ATOM 2188 CA SER A 137
18.920 52.298 26.741 1.00 0.24 C ATOM 2189 C SER A 137 19.203
50.837 26.610 1.00 0.24 C ATOM 2190 O SER A 137 19.102 50.085
27.577 1.00 0.24 O ATOM 2191 CB SER A 137 20.185 52.972 27.299 1.00
0.24 C ATOM 2192 OG SER A 137 21.276 52.795 26.411 1.00 0.24 O ATOM
2193 H SER A 137 17.731 51.800 28.369 1.00 0.00 H ATOM 2194 HA SER
A 137 18.669 52.741 25.782 1.00 0.00 H ATOM 2195 1HB SER A 137
20.484 52.516 28.253 1.00 0.00 H ATOM 2196 2HB SER A 137 20.000
54.044 27.484 1.00 0.00 H ATOM 2197 HG SER A 137 20.990 53.121
25.543 1.00 0.00 H ATOM 2198 N ILE A 138 19.553 50.391 25.389 1.00
0.31 N ATOM 2199 CA ILE A 138 19.872 49.009 25.203 1.00 0.31 C ATOM
2200 C ILE A 138 21.299 48.973 24.779 1.00 0.31 C ATOM 2201 O ILE A
138 21.688 49.613 23.804 1.00 0.31 O ATOM 2202 CB ILE A 138 19.075
48.358 24.114 1.00 0.31 C ATOM 2203 CG1 ILE A 138 17.571 48.461
24.424 1.00 0.31 C ATOM 2204 CG2 ILE A 138 19.578 46.912 23.962
1.00 0.31 C ATOM 2205 CD1 ILE A 138 16.674 48.147 23.229 1.00 0.31
C ATOM 2206 H ILE A 138 19.620 51.007 24.588 1.00 0.00 H ATOM 2207
HA ILE A 138 19.710 48.445 26.135 1.00 0.00 H ATOM 2208 HB ILE A
138 19.268 48.858 23.155 1.00 0.00 H ATOM 2209 1HG1 ILE A 138
17.316 49.490 24.735 1.00 0.00 H ATOM 2210 2HG1 ILE A 138 17.309
47.817 25.281 1.00 0.00 H ATOM 2211 1HG2 ILE A 138 18.854 46.237
23.492 1.00 0.00 H ATOM 2212 2HG2 ILE A 138 20.505 46.865 23.369
1.00 0.00 H ATOM 2213 3HG2 ILE A 138 19.788 46.455 24.944 1.00 0.00
H ATOM 2214 1HD1 ILE A 138 15.696 48.643 23.340 1.00 0.00 H ATOM
2215 2HD1 ILE A 138 17.111 48.502 22.288 1.00 0.00 H ATOM 2216 3HD1
ILE A 138 16.456 47.073 23.163 1.00 0.00 H ATOM 2217 N THR A 139
22.134 48.214 25.502 1.00 0.40 N ATOM 2218 CA THR A 139 23.515
48.187 25.136 1.00 0.40 C ATOM 2219 C THR A 139 23.749 46.939
24.359 1.00 0.40 C ATOM 2220 O THR A 139 23.036 45.952 24.535 1.00
0.40 O ATOM 2221 CB THR A 139 24.443 48.189 26.311 1.00 0.40 C ATOM
2222 OG1 THR A 139 24.163 47.077 27.147 1.00 0.40 O ATOM 2223 CG2
THR A 139 24.261 49.504 27.085 1.00 0.40 C ATOM 2224 H THR A 139
21.880 47.655 26.299 1.00 0.00 H ATOM 2225 HA THR A 139 23.767
49.068 24.524 1.00 0.00 H ATOM 2226 HB THR A 139 25.487 48.132
25.945 1.00 0.00 H ATOM 2227 HG1 THR A 139 24.393 46.277 26.647
1.00 0.00 H ATOM 2228 1HG2 THR A 139 24.974 49.573 27.923 1.00 0.00
H ATOM 2229 2HG2 THR A 139 24.422 50.381 26.437 1.00 0.00 H ATOM
2230 3HG2 THR A 139 23.249 49.577 27.515 1.00 0.00 H ATOM 2231 N
ASN A 140 24.763 46.972 23.470 1.00 0.29 N ATOM 2232 CA ASN A 140
25.086 45.844 22.647 1.00 0.29 C ATOM 2233 C ASN A 140 23.840
45.344 21.994 1.00 0.29 C ATOM 2234 O ASN A 140 23.385 44.235
22.272 1.00 0.29 O ATOM 2235 CB ASN A 140 25.727 44.681 23.423 1.00
0.29 C ATOM 2236 CG ASN A 140 27.131 45.102 23.832 1.00 0.29 C ATOM
2237 OD1 ASN A 140 27.317 45.982 24.671 1.00 0.29 O ATOM 2238 ND2
ASN A 140 28.154 44.447 23.222 1.00 0.29 N ATOM 2239 H ASN A 140
25.351 47.783 23.365 1.00 0.00 H ATOM 2240 HA ASN A 140 25.796
46.179 21.874 1.00 0.00 H ATOM 2241 1HB ASN A 140 25.766 43.791
22.770 1.00 0.00 H ATOM 2242 2HB ASN A 140 25.173 44.406 24.334
1.00 0.00 H ATOM 2243 1HD2 ASN A 140 27.995 43.721 22.547 1.00 0.00
H ATOM 2244 2HD2 ASN A 140 29.087 44.710 23.487 1.00 0.00 H ATOM
2245 N ALA A 141 23.250 46.167 21.107 1.00 0.26 N ATOM 2246 CA ALA
A 141 22.029 45.798 20.453 1.00 0.26 C ATOM 2247 C ALA A 141 22.269
44.561 19.652 1.00 0.26 C ATOM 2248 O ALA A 141 23.383 44.293
19.206 1.00 0.26 O ATOM 2249 CB ALA A 141 21.490 46.878 19.499 1.00
0.26 C ATOM 2250 H ALA A 141 23.587 47.104 20.927 1.00 0.00 H ATOM
2251 HA ALA A 141 21.258 45.608 21.225 1.00 0.00 H ATOM 2252 1HB
ALA A 141 20.549 46.526 19.046 1.00 0.00 H ATOM 2253 2HB ALA A 141
21.267 47.806 20.048 1.00 0.00 H ATOM 2254 3HB ALA A 141 22.201
47.104 18.690 1.00 0.00 H ATOM 2255 N THR A 142 21.198 43.763
19.475 1.00 0.35 N ATOM 2256 CA THR A 142 21.277 42.535 18.746 1.00
0.35 C ATOM 2257 C THR A 142 20.122 42.498 17.797 1.00 0.35 C ATOM
2258 O THR A 142 19.288 43.401 17.779 1.00 0.35 O ATOM 2259 CB THR
A 142 21.175 41.319 19.617 1.00 0.35 C ATOM 2260 OG1 THR A 142
21.424 40.145 18.859 1.00 0.35 O ATOM 2261 CG2 THR A 142 19.764
41.270 20.230 1.00 0.35 C ATOM 2262 H THR A 142 20.268 44.072
19.709 1.00 0.00 H ATOM 2263 HA THR A 142 22.202 42.492 18.164 1.00
0.00 H ATOM 2264 HB THR A 142 21.924 41.382 20.430 1.00 0.00 H ATOM
2265 HG1 THR A 142 20.924 39.425 19.314 1.00 0.00 H ATOM 2266 1HG2
THR A 142 19.677 40.455 20.966 1.00 0.00 H ATOM 2267 2HG2 THR A 142
19.545 42.189 20.799 1.00 0.00 H ATOM 2268 3HG2 THR A 142 19.002
41.155 19.495 1.00 0.00 H ATOM 2269 N VAL A 143 20.067 41.439
16.968 1.00 0.29 N ATOM 2270 CA VAL A 143 19.038 41.271 15.985 1.00
0.29 C ATOM 2271 C VAL A 143 17.723 41.121 16.680 1.00 0.29 C ATOM
2272 O VAL A 143 16.696 41.601 16.203 1.00 0.29 O ATOM 2273 CB VAL
A 143 19.256 40.063 15.127 1.00 0.29 C ATOM 2274 CG1 VAL A 143
18.096 39.966 14.122 1.00 0.29 C ATOM 2275 CG2 VAL A 143 20.644
40.180 14.470 1.00 0.29 C ATOM 2276 H VAL A 143 20.761 40.704
17.079 1.00 0.00 H ATOM 2277 HA VAL A 143 18.850 42.036 15.329 1.00
0.00 H ATOM 2278 HB VAL A 143 19.249 39.139 15.730 1.00 0.00 H ATOM
2279 1HG1 VAL A 143 18.282 39.173 13.377 1.00 0.00 H ATOM 2280 2HG1
VAL A 143 17.142 39.710 14.609 1.00 0.00 H ATOM 2281 3HG1 VAL A 143
17.963 40.905 13.559 1.00 0.00 H ATOM 2282 1HG2 VAL A 143 20.742
39.540 13.578 1.00 0.00 H ATOM 2283 2HG2 VAL A 143 20.859 41.210
14.167 1.00 0.00 H ATOM 2284 3HG2 VAL A 143 21.447 39.879 15.163
1.00 0.00 H ATOM 2285 N GLU A 144 17.728 40.452 17.845 1.00 0.25 N
ATOM 2286 CA GLU A 144 16.522 40.216 18.585 1.00 0.25 C ATOM 2287 C
GLU A 144 15.953 41.542 18.969 1.00 0.25 C ATOM 2288 O GLU A 144
14.738 41.707 19.072 1.00 0.25 O ATOM 2289 CB GLU A 144 16.760
39.414 19.874 1.00 0.25 C ATOM 2290 CG GLU A 144 17.200 37.977
19.597 1.00 0.25 C ATOM 2291 CD GLU A 144 18.626 38.030 19.072 1.00
0.25 C ATOM 2292 OE1 GLU A 144 19.542 38.318 19.886 1.00 0.25 O
ATOM 2293 OE2 GLU A 144 18.817 37.791 17.849 1.00 0.25 O1- ATOM
2294 H GLU A 144 18.487 39.800 18.039 1.00 0.00 H ATOM 2295 HA GLU
A 144 15.773 39.697 17.962 1.00 0.00 H ATOM 2296 1HB GLU A 144
15.791 39.405 20.406 1.00 0.00 H ATOM 2297 2HB GLU A 144 17.460
39.925 20.552 1.00 0.00 H ATOM 2298 1HG GLU A 144 16.520 37.493
18.878 1.00 0.00 H ATOM 2299 2HG GLU A 144 17.181 37.402 20.537
1.00 0.00 H ATOM 2300 N ASP A 145 16.834 42.535 19.171 1.00 0.22 N
ATOM 2301 CA ASP A 145 16.438 43.836 19.619 1.00 0.22 C ATOM 2302 C
ASP A 145 15.451 44.418 18.657 1.00 0.22 C ATOM 2303 O ASP A 145
14.495 45.069 19.079 1.00 0.22 O ATOM 2304 CB ASP A 145 17.632
44.802 19.718 1.00 0.22 C ATOM 2305 CG ASP A 145 17.196 46.073
20.435 1.00 0.22 C ATOM 2306 OD1 ASP A 145 16.201 46.706 19.992
1.00 0.22 O ATOM 2307 OD2 ASP A 145 17.856 46.424 21.448 1.00 0.22
O1- ATOM 2308 H ASP A 145 17.800 42.416 18.901 1.00 0.00 H ATOM
2309 HA ASP A 145 15.940 43.745 20.598 1.00 0.00 H ATOM 2310 1HB
ASP A 145 17.956 45.106 18.717 1.00 0.00 H ATOM 2311 2HB ASP A 145
18.467 44.343 20.264 1.00 0.00 H ATOM 2312 N SER A 146 15.638
44.196 17.341 1.00 0.20 N ATOM 2313 CA SER A 146 14.748 44.779
16.374 1.00 0.20 C ATOM 2314 C SER A 146 13.344 44.384 16.696 1.00
0.20 C ATOM 2315 O SER A 146 13.085 43.287 17.191 1.00 0.20 O ATOM
2316 CB SER A 146 15.037 44.343 14.926 1.00 0.20 C ATOM 2317 OG SER
A 146 14.798 42.951 14.780 1.00 0.20 O ATOM 2318 H SER A 146 16.339
43.525 17.064 1.00 0.00 H ATOM 2319 HA SER A 146 14.867 45.875
16.450 1.00 0.00 H ATOM 2320 1HB SER A 146 16.065 44.568 14.651
1.00 0.00 H ATOM 2321 2HB SER A 146 14.320 44.815 14.248 1.00 0.00
H ATOM 2322 HG SER A 146 15.341 42.471 15.433 1.00 0.00 H ATOM 2323
N GLY A 147 12.394 45.305 16.442 1.00 0.21 N ATOM 2324 CA GLY A 147
11.020 45.025 16.735 1.00 0.21 C ATOM 2325 C GLY A 147 10.301
46.331 16.762 1.00 0.21 C ATOM 2326 O GLY A 147 10.814 47.349
16.299 1.00 0.21 O ATOM 2327 H GLY A 147 12.612 46.212 16.041 1.00
0.00 H ATOM 2328 1HA GLY A 147 10.941 44.526 17.716 1.00 0.00 H
ATOM 2329 2HA GLY A 147 10.566 44.365 15.975 1.00 0.00 H ATOM 2330
N THR A 148 9.071 46.328 17.306 1.00 0.17 N ATOM 2331 CA THR A 148
8.323 47.544 17.360 1.00 0.17 C ATOM 2332 C THR A 148 8.332 47.996
18.779 1.00 0.17 C ATOM 2333 O THR A 148 8.106 47.205 19.694 1.00
0.17 O ATOM 2334 CB THR A 148 6.895 47.375 16.948 1.00 0.17 C ATOM
2335 OG1 THR A 148 6.829 46.867 15.623 1.00 0.17 O ATOM 2336 CG2
THR A 148 6.209 48.746 17.013 1.00 0.17 C ATOM 2337 H THR A 148
8.580 45.466 17.587 1.00 0.00 H ATOM 2338 HA THR A 148 8.769 48.280
16.678 1.00 0.00 H ATOM 2339 HB THR A 148 6.366 46.654 17.589 1.00
0.00 H ATOM 2340 HG1 THR A 148 7.020 47.622 15.041 1.00 0.00 H ATOM
2341 1HG2 THR A 148 5.151 48.632 16.730 1.00 0.00 H ATOM 2342 2HG2
THR A 148 6.285 49.123 18.038 1.00 0.00 H ATOM 2343 3HG2 THR A 148
6.671 49.461 16.318 1.00 0.00 H ATOM 2344 N TYR A 149 8.616 49.292
19.001 1.00 0.12 N ATOM 2345 CA TYR A 149 8.660 49.790 20.343 1.00
0.12 C ATOM 2346 C TYR A 149 7.643 50.872 20.494 1.00 0.12 C ATOM
2347 O TYR A 149 7.419 51.669 19.586 1.00
0.12 O ATOM 2348 CB TYR A 149 9.999 50.438 20.732 1.00 0.12 C ATOM
2349 CG TYR A 149 11.045 49.387 20.866 1.00 0.12 C ATOM 2350 CD1
TYR A 149 11.674 48.868 19.759 1.00 0.12 C ATOM 2351 CD2 TYR A 149
11.402 48.934 22.113 1.00 0.12 C ATOM 2352 CE1 TYR A 149 12.644
47.904 19.899 1.00 0.12 C ATOM 2353 CE2 TYR A 149 12.372 47.971
22.260 1.00 0.12 C ATOM 2354 CZ TYR A 149 12.993 47.454 21.150 1.00
0.12 C ATOM 2355 OH TYR A 149 13.989 46.466 21.293 1.00 0.12 O ATOM
2356 H TYR A 149 8.800 49.943 18.247 1.00 0.00 H ATOM 2357 HA TYR A
149 8.441 48.967 21.010 1.00 0.00 H ATOM 2358 1HB TYR A 149 9.845
50.916 21.708 1.00 0.00 H ATOM 2359 2HB TYR A 149 10.289 51.212
20.005 1.00 0.00 H ATOM 2360 HD1 TYR A 149 11.401 49.211 18.764
1.00 0.00 H ATOM 2361 HD2 TYR A 149 10.960 49.396 22.992 1.00 0.00
H ATOM 2362 HE1 TYR A 149 13.122 47.493 19.011 1.00 0.00 H ATOM
2363 HE2 TYR A 149 13.003 48.093 23.120 1.00 0.00 H ATOM 2364 HH
TYR A 149 14.639 46.549 20.554 1.00 0.00 H ATOM 2365 N TYR A 150
6.980 50.898 21.666 1.00 0.12 N ATOM 2366 CA TYR A 150 6.072 51.960
21.976 1.00 0.12 C ATOM 2367 C TYR A 150 6.183 52.188 23.446 1.00
0.12 C ATOM 2368 O TYR A 150 6.750 51.369 24.169 1.00 0.12 O ATOM
2369 CB TYR A 150 4.570 51.774 21.565 1.00 0.12 C ATOM 2370 CG TYR
A 150 3.990 50.559 22.220 1.00 0.12 C ATOM 2371 CD1 TYR A 150 3.295
50.653 23.419 1.00 0.12 C ATOM 2372 CD2 TYR A 150 4.191 49.295
21.666 1.00 0.12 C ATOM 2373 CE1 TYR A 150 2.907 49.520 24.112 1.00
0.12 C ATOM 2374 CE2 TYR A 150 3.811 48.152 22.340 1.00 0.12 C ATOM
2375 CZ TYR A 150 3.225 48.255 23.614 1.00 0.12 C ATOM 2376 OH TYR
A 150 3.066 47.123 24.350 1.00 0.12 O ATOM 2377 H TYR A 150 7.166
50.227 22.400 1.00 0.00 H ATOM 2378 HA TYR A 150 6.447 52.877
21.485 1.00 0.00 H ATOM 2379 1HB TYR A 150 4.500 51.683 20.480 1.00
0.00 H ATOM 2380 2HB TYR A 150 4.025 52.689 21.836 1.00 0.00 H ATOM
2381 HD1 TYR A 150 3.054 51.631 23.829 1.00 0.00 H ATOM 2382 HD2
TYR A 150 4.684 49.206 20.701 1.00 0.00 H ATOM 2383 HE1 TYR A 150
2.366 49.635 25.050 1.00 0.00 H ATOM 2384 HE2 TYR A 150 3.992
47.177 21.897 1.00 0.00 H ATOM 2385 HH TYR A 150 2.670 47.379
25.192 1.00 0.00 H ATOM 2386 N CYS A 151 5.668 53.328 23.936 1.00
0.27 N ATOM 2387 CA CYS A 151 5.851 53.607 25.325 1.00 0.27 C ATOM
2388 C CYS A 151 4.536 53.997 25.912 1.00 0.27 C ATOM 2389 O CYS A
151 3.648 54.482 25.215 1.00 0.27 O ATOM 2390 CB CYS A 151 6.843
54.762 25.548 1.00 0.27 C ATOM 2391 SG CYS A 151 7.171 55.139
27.291 1.00 0.27 S ATOM 2392 H CYS A 151 5.071 53.942 23.414 1.00
0.00 H ATOM 2393 HA CYS A 151 6.219 52.717 25.849 1.00 0.00 H ATOM
2394 1HB CYS A 151 6.499 55.675 25.037 1.00 0.00 H ATOM 2395 2HB
CYS A 151 7.796 54.462 25.083 1.00 0.00 H ATOM 2396 N THR A 152
4.373 53.738 27.222 1.00 0.37 N ATOM 2397 CA THR A 152 3.202 54.153
27.934 1.00 0.37 C ATOM 2398 C THR A 152 3.659 54.946 29.104 1.00
0.37 C ATOM 2399 O THR A 152 4.747 54.733 29.635 1.00 0.37 O ATOM
2400 CB THR A 152 2.327 53.042 28.434 1.00 0.37 C ATOM 2401 OG1 THR
A 152 3.105 52.054 29.091 1.00 0.37 O ATOM 2402 CG2 THR A 152 1.524
52.454 27.271 1.00 0.37 C ATOM 2403 H THR A 152 5.098 53.297 27.770
1.00 0.00 H ATOM 2404 HA THR A 152 2.623 54.822 27.283 1.00 0.00 H
ATOM 2405 HB THR A 152 1.589 53.466 29.145 1.00 0.00 H ATOM 2406
HG1 THR A 152 3.224 52.392 29.991 1.00 0.00 H ATOM 2407 1HG2 THR A
152 0.849 51.662 27.628 1.00 0.00 H ATOM 2408 2HG2 THR A 152 0.960
53.241 26.770 1.00 0.00 H ATOM 2409 3HG2 THR A 152 2.188 51.996
26.521 1.00 0.00 H ATOM 2410 N GLY A 153 2.829 55.919 29.520 1.00
0.21 N ATOM 2411 CA GLY A 153 3.195 56.730 30.637 1.00 0.21 C ATOM
2412 C GLY A 153 1.974 57.474 31.040 1.00 0.21 C ATOM 2413 O GLY A
153 1.021 57.588 30.271 1.00 0.21 O ATOM 2414 H GLY A 153 1.886
56.034 29.142 1.00 0.00 H ATOM 2415 1HA GLY A 153 3.993 57.444
30.370 1.00 0.00 H ATOM 2416 2HA GLY A 153 3.543 56.101 31.450 1.00
0.00 H ATOM 2417 N LYS A 154 1.972 58.006 32.275 1.00 0.12 N ATOM
2418 CA LYS A 154 0.807 58.711 32.702 1.00 0.12 C ATOM 2419 C LYS A
154 1.155 60.151 32.821 1.00 0.12 C ATOM 2420 O LYS A 154 2.059
60.530 33.565 1.00 0.12 O ATOM 2421 CB LYS A 154 0.290 58.265
34.077 1.00 0.12 C ATOM 2422 CG LYS A 154 -0.176 56.810 34.106 1.00
0.12 C ATOM 2423 CD LYS A 154 -0.395 56.275 35.521 1.00 0.12 C ATOM
2424 CE LYS A 154 -0.863 54.818 35.557 1.00 0.12 C ATOM 2425 NZ LYS
A 154 -1.046 54.378 36.959 1.00 0.12 N1+ ATOM 2426 H LYS A 154
2.733 57.898 32.935 1.00 0.00 H ATOM 2427 HA LYS A 154 0.031 58.632
31.958 1.00 0.00 H ATOM 2428 1HB LYS A 154 -0.526 58.939 34.362
1.00 0.00 H ATOM 2429 2HB LYS A 154 1.176 58.355 34.684 1.00 0.00 H
ATOM 2430 1HG LYS A 154 0.548 56.156 33.586 1.00 0.00 H ATOM 2431
2HG LYS A 154 -1.115 56.752 33.543 1.00 0.00 H ATOM 2432 1HD LYS A
154 -1.072 56.939 36.083 1.00 0.00 H ATOM 2433 2HD LYS A 154 0.602
56.301 35.950 1.00 0.00 H ATOM 2434 1HE LYS A 154 -0.129 54.147
35.080 1.00 0.00 H ATOM 2435 2HE LYS A 154 -1.829 54.686 35.041
1.00 0.00 H ATOM 2436 1HZ LYS A 154 -1.436 53.444 36.999 1.00 0.00
H ATOM 2437 2HZ LYS A 154 -0.179 54.358 37.466 1.00 0.00 H ATOM
2438 3HZ LYS A 154 -1.701 54.977 37.445 1.00 0.00 H ATOM 2439 N VAL
A 155 0.441 60.994 32.056 1.00 0.20 N ATOM 2440 CA VAL A 155 0.620
62.404 32.171 1.00 0.20 C ATOM 2441 C VAL A 155 -0.646 62.882
32.782 1.00 0.20 C ATOM 2442 O VAL A 155 -1.735 62.479 32.374 1.00
0.20 O ATOM 2443 CB VAL A 155 0.804 63.105 30.854 1.00 0.20 C ATOM
2444 CG1 VAL A 155 2.117 62.612 30.221 1.00 0.20 C ATOM 2445 CG2
VAL A 155 -0.439 62.853 29.983 1.00 0.20 C ATOM 2446 H VAL A 155
-0.465 60.701 31.705 1.00 0.00 H ATOM 2447 HA VAL A 155 1.474
62.627 32.829 1.00 0.00 H ATOM 2448 HB VAL A 155 0.898 64.185
31.070 1.00 0.00 H ATOM 2449 1HG1 VAL A 155 2.526 63.319 29.484
1.00 0.00 H ATOM 2450 2HG1 VAL A 155 2.861 62.443 31.007 1.00 0.00
H ATOM 2451 3HG1 VAL A 155 1.975 61.644 29.711 1.00 0.00 H ATOM
2452 1HG2 VAL A 155 -0.249 63.172 28.942 1.00 0.00 H ATOM 2453 2HG2
VAL A 155 -0.649 61.785 29.939 1.00 0.00 H ATOM 2454 3HG2 VAL A 155
-1.343 63.391 30.285 1.00 0.00 H ATOM 2455 N TRP A 156 -0.539
63.723 33.820 1.00 0.33 N ATOM 2456 CA TRP A 156 -1.740 64.153
34.455 1.00 0.33 C ATOM 2457 C TRP A 156 -2.323 62.911 35.034 1.00
0.33 C ATOM 2458 O TRP A 156 -1.605 61.962 35.350 1.00 0.33 O ATOM
2459 CB TRP A 156 -2.765 64.766 33.483 1.00 0.33 C ATOM 2460 CG TRP
A 156 -2.277 66.008 32.771 1.00 0.33 C ATOM 2461 CD1 TRP A 156
-1.694 66.113 31.543 1.00 0.33 C ATOM 2462 CD2 TRP A 156 -2.345
67.341 33.303 1.00 0.33 C ATOM 2463 NE1 TRP A 156 -1.392 67.427
31.275 1.00 0.33 N ATOM 2464 CE2 TRP A 156 -1.787 68.195 32.350
1.00 0.33 C ATOM 2465 CE3 TRP A 156 -2.832 67.816 34.487 1.00 0.33
C ATOM 2466 CZ2 TRP A 156 -1.705 69.541 32.569 1.00 0.33 C ATOM
2467 CZ3 TRP A 156 -2.748 69.175 34.703 1.00 0.33 C ATOM 2468 CH2
TRP A 156 -2.195 70.021 33.763 1.00 0.33 C ATOM 2469 H TRP A 156
0.348 64.062 34.155 1.00 0.00 H ATOM 2470 HA TRP A 156 -1.505
64.859 35.270 1.00 0.00 H ATOM 2471 1HB TRP A 156 -3.617 65.114
34.092 1.00 0.00 H ATOM 2472 2HB TRP A 156 -3.230 64.080 32.765
1.00 0.00 H ATOM 2473 HD1 TRP A 156 -1.470 65.339 30.827 1.00 0.00
H ATOM 2474 HE1 TRP A 156 -0.853 67.759 30.508 1.00 0.00 H ATOM
2475 HE3 TRP A 156 -3.265 67.164 35.237 1.00 0.00 H ATOM 2476 HZ2
TRP A 156 -1.272 70.204 31.826 1.00 0.00 H ATOM 2477 HZ3 TRP A 156
-3.122 69.593 35.635 1.00 0.00 H ATOM 2478 HH2 TRP A 156 -2.143
71.087 33.972 1.00 0.00 H ATOM 2479 N GLN A 157 -3.656 62.899
35.190 1.00 0.49 N ATOM 2480 CA GLN A 157 -4.338 61.769 35.739 1.00
0.49 C ATOM 2481 C GLN A 157 -4.276 60.630 34.773 1.00 0.49 C ATOM
2482 O GLN A 157 -4.048 59.485 35.160 1.00 0.49 O ATOM 2483 CB GLN
A 157 -5.830 62.050 35.969 1.00 0.49 C ATOM 2484 CG GLN A 157
-6.082 63.297 36.814 1.00 0.49 C ATOM 2485 CD GLN A 157 -5.294
63.145 38.101 1.00 0.49 C ATOM 2486 OE1 GLN A 157 -5.354 62.107
38.756 1.00 0.49 O ATOM 2487 NE2 GLN A 157 -4.525 64.203 38.466
1.00 0.49 N ATOM 2488 H GLN A 157 -4.225 63.687 34.941 1.00 0.00 H
ATOM 2489 HA GLN A 157 -3.849 61.453 36.673 1.00 0.00 H ATOM 2490
1HB GLN A 157 -6.280 61.160 36.442 1.00 0.00 H ATOM 2491 2HB GLN A
157 -6.355 62.215 35.031 1.00 0.00 H ATOM 2492 1HG GLN A 157 -7.147
63.381 37.094 1.00 0.00 H ATOM 2493 2HG GLN A 157 -5.821 64.214
36.260 1.00 0.00 H ATOM 2494 1HE2 GLN A 157 -4.495 65.056 37.942
1.00 0.00 H ATOM 2495 2HE2 GLN A 157 -3.997 64.103 39.316 1.00 0.00
H ATOM 2496 N LEU A 158 -4.459 60.932 33.473 1.00 0.41 N ATOM 2497
CA LEU A 158 -4.607 59.905 32.483 1.00 0.41 C ATOM 2498 C LEU A 158
-3.306 59.269 32.127 1.00 0.41 C ATOM 2499 O LEU A 158 -2.227
59.803 32.381 1.00 0.41 O ATOM 2500 CE LEU A 158 -5.252 60.399
31.176 1.00 0.41 C ATOM 2501 CG LEU A 158 -6.699 60.889 31.364 1.00
0.41 C ATOM 2502 CD1 LEU A 158 -7.628 59.742 31.796 1.00 0.41 C
ATOM 2503 CD2 LEU A 158 -6.758 62.101 32.310 1.00 0.41 C ATOM 2504
H LEU A 158 -4.372 61.876 33.144 1.00 0.00 H ATOM 2505 HA LEU A 158
-5.247 59.120 32.926 1.00 0.00 H ATOM 2506 1HB LEU A 158 -5.231
59.590 30.425 1.00 0.00 H ATOM 2507 2HB LEU A 158 -4.656 61.226
30.773 1.00 0.00 H ATOM 2508 HG LEU A 158 -7.047 61.227 30.367 1.00
0.00 H ATOM 2509 1HD1 LEU A 158 -8.682 60.066 31.788 1.00 0.00 H
ATOM 2510 2HD1 LEU A 158 -7.548 58.883 31.108 1.00 0.00 H ATOM 2511
3HD1 LEU A 158 -7.408 59.385 32.814 1.00 0.00 H ATOM 2512 1HD2 LEU
A 158 -7.652 62.708 32.086 1.00 0.00 H ATOM 2513 2HD2 LEU A 158
-6.896 61.750 33.331 1.00 0.00 H ATOM 2514 3HD2 LEU A 158 -5.894
62.776 32.222 1.00 0.00 H ATOM 2515 N ASP A 159 -3.419 58.062
31.533 1.00 0.19 N ATOM 2516 CA ASP A 159 -2.310 57.288 31.058 1.00
0.19 C ATOM 2517 C ASP A 159 -2.414 57.323 29.566 1.00 0.19 C ATOM
2518 O ASP A 159 -3.504 57.198 29.009 1.00 0.19 O ATOM 2519 CB ASP
A 159 -2.381 55.809 31.503 1.00 0.19 C ATOM 2520 CG ASP A 159
-1.124 55.027 31.117 1.00 0.19 C ATOM 2521 OD1 ASP A 159 -0.378
55.468 30.205 1.00 0.19 O ATOM 2522 OD2 ASP A 159 -0.904 53.956
31.744 1.00 0.19 O1- ATOM 2523 H ASP A 159 -4.304 57.666 31.271
1.00 0.00 H ATOM 2524 HA ASP A 159 -1.394 57.724 31.412 1.00 0.00 H
ATOM 2525 1HB ASP A 159 -3.242 55.320 31.016 1.00 0.00 H ATOM 2526
2HB ASP A 159 -2.577 55.702 32.580 1.00 0.00 H ATOM 2527 N TYR A
160 -1.279 57.531 28.874 1.00 0.11 N ATOM 2528 CA TYR A 160 -1.321
57.584 27.443 1.00 0.11 C ATOM 2529 C TYR A 160 -0.381 56.562
26.901 1.00 0.11 C ATOM 2530 O TYR A 160 0.535 56.111 27.589 1.00
0.11 O ATOM 2531 CB TYR A 160 -0.884 58.937 26.857 1.00 0.11 C ATOM
2532 CG TYR A 160 -1.939 59.942 27.171 1.00 0.11 C ATOM 2533 CD1
TYR A 160 -2.067 60.462 28.439 1.00 0.11 C ATOM 2534 CD2 TYR A 160
-2.794 60.378 26.185 1.00 0.11 C ATOM 2535 CE1 TYR A 160 -3.042
61.390 28.720 1.00 0.11 C ATOM 2536 CE2 TYR A 160 -3.771 61.306
26.459 1.00 0.11 C ATOM 2537 CZ TYR A 160 -3.895 61.814 27.730 1.00
0.11 C ATOM 2538 OH TYR A 160 -4.895 62.767 28.019 1.00 0.11 O ATOM
2539 H TYR A 160 -0.429 57.158 29.312 1.00 0.00 H ATOM 2540 HA TYR
A 160 -2.323 57.325 27.087 1.00 0.00 H ATOM 2541 1HB TYR A 160
-0.756 58.828 25.769 1.00 0.00 H ATOM 2542 2HB TYR A 160 0.099
59.231 27.261 1.00 0.00 H ATOM 2543 HD1 TYR A 160 -1.420 60.088
29.225 1.00 0.00 H ATOM 2544 HD2 TYR A 160 -2.708 59.975 25.179
1.00 0.00 H ATOM 2545 HE1 TYR A 160 -3.087 61.827 29.711 1.00 0.00
H ATOM 2546 HE2 TYR A 160 -4.440 61.623 25.662 1.00 0.00 H ATOM
2547 HH TYR A 160 -5.696 62.470 27.566 1.00 0.00 H ATOM 2548 N GLU
A 161 -0.622 56.144 25.643 1.00 0.12 N ATOM 2549 CA GLU A 161 0.262
55.219 25.000 1.00 0.12 C ATOM 2550 C GLU A 161 0.753 55.893 23.762
1.00 0.12 C ATOM 2551 O GLU A 161 0.033 56.669 23.135 1.00 0.12 O
ATOM 2552 CB GLU A 161 -0.537 53.970 24.530 1.00 0.12 C ATOM 2553
CG GLU A 161 -1.765 53.494 25.343 1.00 0.12 C ATOM 2554 CD GLU A
161 -1.424 52.544 26.509 1.00 0.12 C ATOM 2555 OE1 GLU A 161 -1.294
51.360 26.186 1.00 0.12 O ATOM 2556 OE2 GLU A 161 -1.270 53.072
27.616 1.00 0.12 O1- ATOM 2557 H GLU A 161 -1.390 56.468 25.083
1.00 0.00 H ATOM 2558 HA GLU A 161 1.082 54.949 25.668 1.00 0.00 H
ATOM 2559 1HB GLU A 161 0.157 53.123 24.376 1.00 0.00 H ATOM 2560
2HB GLU A 161 -0.927 54.220 23.531 1.00 0.00 H ATOM 2561 1HG GLU A
161 -2.415 52.932 24.651 1.00 0.00 H ATOM 2562 2HG GLU A 161 -2.358
54.344 25.709 1.00 0.00 H ATOM 2563 N SER A 162 2.020 55.632 23.397
1.00 0.11 N ATOM 2564 CA SER A 162 2.598 56.250 22.242 1.00 0.11 C
ATOM 2565 C SER A 162 2.381 55.367 21.065 1.00 0.11 C ATOM 2566 O
SER A 162 1.967 54.216 21.196 1.00 0.11 O ATOM 2567 CB SER A 162
4.113 56.489 22.371 1.00 0.11 C ATOM 2568 OG SER A 162 4.614 57.110
21.196 1.00 0.11 O ATOM 2569 H SER A 162 2.604 55.025 23.964 1.00
0.00 H ATOM 2570 HA SER A 162 2.118 57.229 22.070 1.00 0.00 H ATOM
2571 1HB SER A 162 4.627 55.527 22.518 1.00 0.00 H ATOM 2572 2HB
SER A 162 4.316 57.117 23.249 1.00 0.00 H ATOM 2573 HG SER A 162
5.577 57.118 21.318 1.00 0.00 H ATOM 2574 N GLU A 163 2.640 55.915
19.864 1.00 0.13 N ATOM 2575 CA GLU A 163 2.517 55.151 18.661 1.00
0.13 C ATOM 2576 C GLU A 163 3.757 54.333 18.544 1.00 0.13 C ATOM
2577 O GLU A 163 4.830 54.718 19.006 1.00 0.13 O ATOM 2578 CB GLU A
163 2.382 56.031 17.407 1.00 0.13 C ATOM 2579 CG GLU A 163 3.567
56.976 17.202 1.00 0.13 C ATOM 2580 CD GLU A 163 3.153 58.020
16.177 1.00 0.13 C ATOM 2581 OE1 GLU A 163 2.076 58.643 16.381 1.00
0.13 O ATOM 2582 OE2 GLU A 163 3.900 58.212 15.181 1.00 0.13 O1-
ATOM 2583 H GLU A 163 3.159 56.782 19.804 1.00 0.00 H ATOM 2584 HA
GLU A 163 1.565 54.603 18.736 1.00 0.00 H ATOM 2585 1HB GLU A 163
1.438 56.596 17.501 1.00 0.00 H ATOM 2586 2HB GLU A 163 2.265
55.357 16.540 1.00 0.00 H ATOM 2587 1HG GLU A 163 4.481 56.445
16.900 1.00 0.00 H ATOM 2588 2HG GLU A 163 3.766 57.518 18.137 1.00
0.00 H ATOM 2589 N PRO A 164 3.611 53.185 17.956 1.00 0.13 N ATOM
2590 CA PRO A 164 4.751 52.324 17.819 1.00 0.13 C ATOM 2591 C PRO A
164 5.680 52.796 16.752 1.00 0.13 C ATOM 2592 O PRO A 164 5.235
53.459 15.818 1.00 0.13 O ATOM 2593 CB PRO A 164 4.189 50.930
17.565 1.00 0.13 C ATOM 2594 CG PRO A 164 2.815 50.957 18.251 1.00
0.13 C ATOM 2595 CD PRO A 164 2.385 52.429 18.167 1.00 0.13 C ATOM
2596 HA PRO A 164 5.289 52.312 18.774 1.00 0.00 H ATOM 2597 1HB PRO
A 164 4.769 50.185 18.092 1.00 0.00 H ATOM 2598 2HB PRO A 164 4.113
50.690 16.495 1.00 0.00 H ATOM 2599 1HG PRO A 164 2.920 50.648
19.303 1.00 0.00 H ATOM 2600 2HG PRO A 164 2.075 50.275 17.803 1.00
0.00 H ATOM 2601 1HD PRO A 164 1.700 52.602 17.322 1.00 0.00 H ATOM
2602 2HD PRO A 164 1.875 52.702 19.099 1.00 0.00 H ATOM 2603 N LEU
A 165 6.982 52.483 16.888 1.00 0.11 N ATOM 2604 CA LEU A 165 7.932
52.840 15.879 1.00 0.11 C ATOM 2605 C LEU A 165 8.678 51.587 15.565
1.00 0.11 C ATOM 2606 O LEU A 165 8.896 50.754 16.444 1.00 0.11 O
ATOM 2607 CB LEU A 165 8.953 53.897 16.327 1.00 0.11 C ATOM 2608 CG
LEU A 165 8.309 55.248 16.688 1.00 0.11 C ATOM 2609 CD1 LEU A 165
9.377 56.304 17.011 1.00 0.11 C ATOM 2610 CD2 LEU A 165 7.321
55.708 15.605 1.00 0.11 C ATOM 2611 H LEU A 165 7.333 52.020 17.718
1.00 0.00 H ATOM 2612 HA LEU A 165 7.399 53.174 14.975 1.00 0.00 H
ATOM 2613 1HB LEU A 165 9.663 54.039 15.492 1.00 0.00 H ATOM 2614
2HB LEU A 165 9.540 53.512 17.180 1.00 0.00 H ATOM 2615 HG LEU A
165 7.725 55.110 17.619 1.00 0.00 H ATOM 2616 1HD1 LEU A 165 8.889
57.250 17.269 1.00 0.00 H ATOM 2617 2HD1 LEU A 165 10.014 55.959
17.841 1.00 0.00 H ATOM 2618 3HD1 LEU A 165 10.045 56.456 16.150
1.00 0.00 H ATOM 2619 1HD2 LEU A 165 7.258 56.806 15.620 1.00 0.00
H ATOM 2620 2HD2 LEU A 165 7.617 55.405 14.591 1.00 0.00 H ATOM
2621 3HD2 LEU A 165 6.293 55.405 15.796 1.00 0.00 H ATOM 2622 N ASN
A 166 9.077 51.402 14.294 1.00 0.10 N ATOM 2623 CA ASN A 166 9.772
50.192 13.976 1.00 0.10 C ATOM 2624 C ASN A 166 11.234 50.478
14.008 1.00 0.10 C ATOM 2625 O ASN A 166 11.729 51.346 13.291 1.00
0.10 O ATOM 2626 CB ASN A 166 9.460 49.623 12.581 1.00 0.10 C ATOM
2627 CG ASN A 166 8.056 49.035 12.593 1.00 0.10 C ATOM 2628 OD1 ASN
A 166 7.304 49.185 13.555 1.00 0.10 O ATOM 2629 ND2 ASN A 166 7.695
48.328 11.490 1.00 0.10 N ATOM 2630 H ASN A 166 8.934 52.059 13.548
1.00 0.00 H ATOM 2631 HA ASN A 166 9.513 49.396 14.694 1.00 0.00 H
ATOM 2632 1HB ASN A 166 10.186 48.815 12.378 1.00 0.00 H ATOM 2633
2HB ASN A 166 9.555 50.379 11.786 1.00 0.00 H ATOM 2634 1HD2 ASN A
166 8.315 48.199 10.712 1.00 0.00
H ATOM 2635 2HD2 ASN A 166 6.774 47.924 11.489 1.00 0.00 H ATOM
2636 N ILE A 167 11.959 49.747 14.873 1.00 0.22 N ATOM 2637 CA ILE
A 167 13.378 49.904 14.942 1.00 0.22 C ATOM 2638 C ILE A 167 13.954
48.591 14.545 1.00 0.22 C ATOM 2639 O ILE A 167 13.535 47.544
15.035 1.00 0.22 O ATOM 2640 CB ILE A 167 13.880 50.216 16.322 1.00
0.22 C ATOM 2641 CG1 ILE A 167 13.316 51.562 16.805 1.00 0.22 C
ATOM 2642 CG2 ILE A 167 15.418 50.161 16.294 1.00 0.22 C ATOM 2643
CD1 ILE A 167 13.532 51.815 18.297 1.00 0.22 C ATOM 2644 H ILE A
167 11.571 48.981 15.415 1.00 0.00 H ATOM 2645 HA ILE A 167 13.699
50.705 14.261 1.00 0.00 H ATOM 2646 HB ILE A 167 13.530 49.426
17.014 1.00 0.00 H ATOM 2647 1HG1 ILE A 167 12.227 51.610 16.623
1.00 0.00 H ATOM 2648 2HG1 ILE A 167 13.758 52.388 16.219 1.00 0.00
H ATOM 2649 1HG2 ILE A 167 15.829 50.322 17.306 1.00 0.00 H ATOM
2650 2HG2 ILE A 167 15.817 49.186 15.976 1.00 0.00 H ATOM 2651 3HG2
ILE A 167 15.852 50.951 15.670 1.00 0.00 H ATOM 2652 1HD1 ILE A 167
13.012 52.730 18.621 1.00 0.00 H ATOM 2653 2HD1 ILE A 167 13.158
50.981 18.909 1.00 0.00 H ATOM 2654 3HD1 ILE A 167 14.602 51.943
18.511 1.00 0.00 H ATOM 2655 N THR A 168 14.926 48.604 13.618 1.00
0.48 N ATOM 2656 CA THR A 168 15.488 47.353 13.212 1.00 0.48 C ATOM
2657 C THR A 168 16.955 47.396 13.410 1.00 0.48 C ATOM 2658 O THR A
168 17.587 48.447 13.312 1.00 0.48 O ATOM 2659 CB THR A 168 15.289
47.020 11.764 1.00 0.48 C ATOM 2660 OG1 THR A 168 15.798 48.064
10.948 1.00 0.48 O ATOM 2661 CG2 THR A 168 13.800 46.788 11.494
1.00 0.48 C ATOM 2662 H THR A 168 15.334 49.451 13.242 1.00 0.00 H
ATOM 2663 HA THR A 168 15.086 46.551 13.823 1.00 0.00 H ATOM 2664
HB THR A 168 15.828 46.078 11.542 1.00 0.00 H ATOM 2665 HG1 THR A
168 16.752 48.111 11.107 1.00 0.00 H ATOM 2666 1HG2 THR A 168
13.629 46.488 10.447 1.00 0.00 H ATOM 2667 2HG2 THR A 168 13.392
45.995 12.141 1.00 0.00 H ATOM 2668 3HG2 THR A 168 13.218 47.707
11.670 1.00 0.00 H ATOM 2669 N VAL A 169 17.538 46.228 13.724 1.00
0.55 N ATOM 2670 CA VAL A 169 18.958 46.199 13.795 1.00 0.55 C ATOM
2671 C VAL A 169 19.375 45.828 12.415 1.00 0.55 C ATOM 2672 O VAL A
169 18.935 44.820 11.863 1.00 0.55 O ATOM 2673 CB VAL A 169 19.532
45.207 14.771 1.00 0.55 C ATOM 2674 CG1 VAL A 169 19.096 45.621
16.183 1.00 0.55 C ATOM 2675 CG2 VAL A 169 19.102 43.782 14.391
1.00 0.55 C ATOM 2676 H VAL A 169 17.097 45.329 13.643 1.00 0.00 H
ATOM 2677 HA VAL A 169 19.344 47.190 14.069 1.00 0.00 H ATOM 2678
HB VAL A 169 20.631 45.296 14.679 1.00 0.00 H ATOM 2679 1HG1 VAL A
169 19.882 45.432 16.925 1.00 0.00 H ATOM 2680 2HG1 VAL A 169
18.919 46.708 16.250 1.00 0.00 H ATOM 2681 3HG1 VAL A 169 18.150
45.151 16.482 1.00 0.00 H ATOM 2682 1HG2 VAL A 169 19.961 43.256
14.838 1.00 0.00 H ATOM 2683 2HG2 VAL A 169 18.107 43.608 14.822
1.00 0.00 H ATOM 2684 3HG2 VAL A 169 19.091 43.378 13.385 1.00 0.00
H ATOM 2685 N ILE A 170 20.221 46.672 11.807 1.00 0.56 N ATOM 2686
CA ILE A 170 20.637 46.451 10.457 1.00 0.56 C ATOM 2687 C ILE A 170
21.357 45.145 10.428 1.00 0.56 C ATOM 2688 O ILE A 170 21.198
44.364 9.490 1.00 0.56 O ATOM 2689 CB ILE A 170 21.546 47.545 9.942
1.00 0.56 C ATOM 2690 CG1 ILE A 170 21.728 47.467 8.414 1.00 0.56 C
ATOM 2691 CG2 ILE A 170 22.867 47.492 10.727 1.00 0.56 C ATOM 2692
CD1 ILE A 170 22.467 46.223 7.921 1.00 0.56 C ATOM 2693 H ILE A 170
20.615 47.485 12.272 1.00 0.00 H ATOM 2694 HA ILE A 170 19.739
46.349 9.824 1.00 0.00 H ATOM 2695 HB ILE A 170 21.142 48.513
10.164 1.00 0.00 H ATOM 2696 1HG1 ILE A 170 22.296 48.360 8.094
1.00 0.00 H ATOM 2697 2HG1 ILE A 170 20.748 47.543 7.909 1.00 0.00
H ATOM 2698 1HG2 ILE A 170 23.219 48.524 10.855 1.00 0.00 H ATOM
2699 2HG2 ILE A 170 22.796 47.047 11.714 1.00 0.00 H ATOM 2700 3HG2
ILE A 170 23.675 46.954 10.210 1.00 0.00 H ATOM 2701 1HD1 ILE A 170
23.115 46.497 7.070 1.00 0.00 H ATOM 2702 2HD1 ILE A 170 23.131
45.742 8.651 1.00 0.00 H ATOM 2703 3HD1 ILE A 170 21.776 45.472
7.510 1.00 0.00 H ATOM 2704 N LYS A 171 22.156 44.867 11.475 1.00
0.52 N ATOM 2705 CA LYS A 171 22.902 43.646 11.537 1.00 0.52 C ATOM
2706 C LYS A 171 21.908 42.536 11.406 1.00 0.52 C ATOM 2707 O LYS A
171 20.957 42.448 12.180 1.00 0.52 O ATOM 2708 CB LYS A 171 23.649
43.510 12.879 1.00 0.52 C ATOM 2709 CG LYS A 171 24.731 42.430
12.935 1.00 0.52 C ATOM 2710 CD LYS A 171 24.206 41.006 12.790 1.00
0.52 C ATOM 2711 CE LYS A 171 25.263 39.934 13.064 1.00 0.52 C ATOM
2712 NZ LYS A 171 26.436 40.153 12.190 1.00 0.52 N1+ ATOM 2713 H
LYS A 171 22.064 45.419 12.309 1.00 0.00 H ATOM 2714 HA LYS A 171
23.632 43.648 10.707 1.00 0.00 H ATOM 2715 1HB LYS A 171 22.872
43.341 13.643 1.00 0.00 H ATOM 2716 2HB LYS A 171 24.129 44.479
13.070 1.00 0.00 H ATOM 2717 1HG LYS A 171 25.345 42.498 13.836
1.00 0.00 H ATOM 2718 2HG LYS A 171 25.440 42.623 12.108 1.00 0.00
H ATOM 2719 1HD LYS A 171 23.964 40.933 11.730 1.00 0.00 H ATOM
2720 2HD LYS A 171 23.302 40.816 13.390 1.00 0.00 H ATOM 2721 1HE
LYS A 171 24.877 38.923 12.853 1.00 0.00 H ATOM 2722 2HE LYS A 171
25.630 39.937 14.101 1.00 0.00 H ATOM 2723 1HZ LYS A 171 27.152
39.454 12.333 1.00 0.00 H ATOM 2724 2HZ LYS A 171 26.174 40.112
11.214 1.00 0.00 H ATOM 2725 3HZ LYS A 171 26.861 41.053 12.366
1.00 0.00 H ATOM 2726 N ALA A 172 22.097 41.667 10.393 1.00 0.31 N
ATOM 2727 CA ALA A 172 21.148 40.617 10.164 1.00 0.31 C ATOM 2728 C
ALA A 172 21.773 39.272 10.514 1.00 0.31 C ATOM 2729 O ALA A 172
21.353 38.260 9.895 1.00 0.31 O ATOM 2730 CB ALA A 172 20.692
40.524 8.698 1.00 0.31 C ATOM 2731 OXT ALA A 172 22.663 39.229
11.402 1.00 0.31 O1- ATOM 2732 H ALA A 172 22.807 41.776 9.698 1.00
0.00 H ATOM 2733 HA ALA A 172 20.252 40.765 10.785 1.00 0.00 H ATOM
2734 1HB ALA A 172 19.857 39.810 8.602 1.00 0.00 H ATOM 2735 2HB
ALA A 172 20.320 41.491 8.321 1.00 0.00 H ATOM 2736 3HB ALA A 172
21.505 40.199 8.030 1.00 0.00 H ATOM 2737 N VAL B 1 -35.035 33.443
-3.312 1.00 0.14 N1+ ATOM 2738 CA VAL B 1 -36.312 33.784 -2.644
1.00 0.14 C ATOM 2739 C VAL B 1 -36.557 33.129 -1.314 1.00 0.14 C
ATOM 2740 O VAL B 1 -37.357 33.653 -0.542 1.00 0.14 O ATOM 2741 CB
VAL B 1 -37.484 33.539 -3.566 1.00 0.14 C ATOM 2742 CG1 VAL B 1
-37.364 34.515 -4.747 1.00 0.14 C ATOM 2743 CG2 VAL B 1 -37.528
32.067 -4.005 1.00 0.14 C ATOM 2744 1H VAL B 1 -34.869 34.004
-4.138 1.00 0.00 H ATOM 2745 2H VAL B 1 -34.241 33.598 -2.703 1.00
0.00 H ATOM 2746 3H VAL B 1 -34.995 32.476 -3.602 1.00 0.00 H ATOM
2747 HA VAL B 1 -36.235 34.860 -2.400 1.00 0.00 H ATOM 2748 HB VAL
B 1 -38.411 33.777 -3.011 1.00 0.00 H ATOM 2749 1HG1 VAL B 1
-38.229 34.435 -5.429 1.00 0.00 H ATOM 2750 2HG1 VAL B 1 -37.326
35.564 -4.406 1.00 0.00 H ATOM 2751 3HG1 VAL B 1 -36.463 34.319
-5.351 1.00 0.00 H ATOM 2752 1HG2 VAL B 1 -38.228 31.983 -4.860
1.00 0.00 H ATOM 2753 2HG2 VAL B 1 -36.576 31.696 -4.412 1.00 0.00
H ATOM 2754 3HG2 VAL B 1 -38.001 31.421 -3.249 1.00 0.00 H ATOM
2755 N PRO B 2 -35.933 32.030 -0.959 1.00 0.15 N ATOM 2756 CA PRO B
2 -36.195 31.541 0.363 1.00 0.15 C ATOM 2757 C PRO B 2 -35.493
32.410 1.350 1.00 0.15 C ATOM 2758 O PRO B 2 -34.546 33.097 0.973
1.00 0.15 O ATOM 2759 CB PRO B 2 -35.731 30.088 0.391 1.00 0.15 C
ATOM 2760 CG PRO B 2 -35.897 29.635 -1.067 1.00 0.15 C ATOM 2761 CD
PRO B 2 -35.709 30.924 -1.884 1.00 0.15 C ATOM 2762 HA PRO B 2
-37.285 31.530 0.558 1.00 0.00 H ATOM 2763 1HB PRO B 2 -36.304
29.496 1.118 1.00 0.00 H ATOM 2764 2HB PRO B 2 -34.669 30.026 0.677
1.00 0.00 H ATOM 2765 1HG PRO B 2 -36.917 29.240 -1.212 1.00 0.00 H
ATOM 2766 2HG PRO B 2 -35.203 28.833 -1.366 1.00 0.00 H ATOM 2767
1HD PRO B 2 -34.667 30.980 -2.239 1.00 0.00 H ATOM 2768 2HD PRO B 2
-36.339 30.824 -2.732 1.00 0.00 H ATOM 2769 N GLN B 3 -35.941
32.393 2.617 1.00 0.19 N ATOM 2770 CA GLN B 3 -35.329 33.215 3.614
1.00 0.19 C ATOM 2771 C GLN B 3 -33.901 32.793 3.703 1.00 0.19 C
ATOM 2772 O GLN B 3 -33.553 31.670 3.339 1.00 0.19 O ATOM 2773 CB
GLN B 3 -35.986 33.063 4.996 1.00 0.19 C ATOM 2774 CG GLN B 3
-35.493 34.064 6.040 1.00 0.19 C ATOM 2775 CD GLN B 3 -36.327
33.844 7.293 1.00 0.19 C ATOM 2776 OE1 GLN B 3 -36.930 32.787 7.467
1.00 0.19 O ATOM 2777 NE2 GLN B 3 -36.374 34.869 8.185 1.00 0.19 N
ATOM 2778 H GLN B 3 -36.686 31.783 2.909 1.00 0.00 H ATOM 2779 HA
GLN B 3 -35.401 34.270 3.289 1.00 0.00 H ATOM 2780 1HB GLN B 3
-35.828 32.030 5.351 1.00 0.00 H ATOM 2781 2HB GLN B 3 -37.076
33.203 4.874 1.00 0.00 H ATOM 2782 1HG GLN B 3 -35.596 35.097 5.669
1.00 0.00 H ATOM 2783 2HG GLN B 3 -34.444 33.879 6.303 1.00 0.00 H
ATOM 2784 1HE2 GLN B 3 -36.282 35.816 7.857 1.00 0.00 H ATOM 2785
2HE2 GLN B 3 -37.049 34.698 8.921 1.00 0.00 H ATOM 2786 N LYS B 4
-33.024 33.701 4.172 1.00 0.23 N ATOM 2787 CA LYS B 4 -31.626
33.390 4.219 1.00 0.23 C ATOM 2788 C LYS B 4 -31.282 32.929 5.594
1.00 0.23 C ATOM 2789 O LYS B 4 -31.667 33.518 6.603 1.00 0.23 O
ATOM 2790 CB LYS B 4 -30.722 34.593 3.904 1.00 0.23 C ATOM 2791 CG
LYS B 4 -30.861 35.101 2.467 1.00 0.23 C ATOM 2792 CD LYS B 4
-30.229 36.477 2.241 1.00 0.23 C ATOM 2793 CE LYS B 4 -31.032
37.624 2.856 1.00 0.23 C ATOM 2794 NZ LYS B 4 -30.320 38.907 2.659
1.00 0.23 N1+ ATOM 2795 H LYS B 4 -33.282 34.648 4.377 1.00 0.00 H
ATOM 2796 HA LYS B 4 -31.442 32.662 3.416 1.00 0.00 H ATOM 2797 1HB
LYS B 4 -29.665 34.343 4.096 1.00 0.00 H ATOM 2798 2HB LYS B 4
-30.952 35.398 4.623 1.00 0.00 H ATOM 2799 1HG LYS B 4 -31.919
35.129 2.150 1.00 0.00 H ATOM 2800 2HG LYS B 4 -30.360 34.380 1.801
1.00 0.00 H ATOM 2801 1HD LYS B 4 -30.132 36.650 1.154 1.00 0.00 H
ATOM 2802 2HD LYS B 4 -29.200 36.464 2.645 1.00 0.00 H ATOM 2803
1HE LYS B 4 -31.168 37.502 3.942 1.00 0.00 H ATOM 2804 2HE LYS B 4
-32.027 37.717 2.391 1.00 0.00 H ATOM 2805 1HZ LYS B 4 -30.819
39.699 3.042 1.00 0.00 H ATOM 2806 2HZ LYS B 4 -29.420 38.885 3.134
1.00 0.00 H ATOM 2807 3HZ LYS B 4 -30.141 39.110 1.685 1.00 0.00 H
ATOM 2808 N PRO B 5 -30.550 31.853 5.616 1.00 0.25 N ATOM 2809 CA
PRO B 5 -30.108 31.251 6.840 1.00 0.25 C ATOM 2810 C PRO B 5
-29.273 32.279 7.522 1.00 0.25 C ATOM 2811 O PRO B 5 -28.730 33.147
6.839 1.00 0.25 O ATOM 2812 CB PRO B 5 -29.231 30.082 6.411 1.00
0.25 C ATOM 2813 CG PRO B 5 -28.592 30.609 5.112 1.00 0.25 C ATOM
2814 CD PRO B 5 -29.678 31.516 4.507 1.00 0.25 C ATOM 2815 HA PRO B
5 -30.972 30.960 7.456 1.00 0.00 H ATOM 2816 1HB PRO B 5 -29.730
29.123 6.357 1.00 0.00 H ATOM 2817 2HB PRO B 5 -28.453 29.911 7.178
1.00 0.00 H ATOM 2818 1HG PRO B 5 -28.174 29.894 4.412 1.00 0.00 H
ATOM 2819 2HG PRO B 5 -27.910 31.344 5.421 1.00 0.00 H ATOM 2820
1HD PRO B 5 -29.236 32.397 4.044 1.00 0.00 H ATOM 2821 2HD PRO B 5
-30.320 31.045 3.774 1.00 0.00 H ATOM 2822 N LYS B 6 -29.172 32.227
8.861 1.00 0.35 N ATOM 2823 CA LYS B 6 -28.336 33.181 9.520 1.00
0.35 C ATOM 2824 C LYS B 6 -27.209 32.429 10.136 1.00 0.35 C ATOM
2825 O LYS B 6 -27.391 31.333 10.666 1.00 0.35 O ATOM 2826 CB LYS B
6 -29.033 33.969 10.641 1.00 0.35 C ATOM 2827 CG LYS B 6 -30.016
35.023 10.127 1.00 0.35 C ATOM 2828 CD LYS B 6 -31.243 34.436 9.427
1.00 0.35 C ATOM 2829 CE LYS B 6 -32.218 35.501 8.920 1.00 0.35 C
ATOM 2830 NZ LYS B 6 -33.370 34.856 8.253 1.00 0.35 N1+ ATOM 2831 H
LYS B 6 -29.531 31.470 9.434 1.00 0.00 H ATOM 2832 HA LYS B 6
-27.947 33.923 8.805 1.00 0.00 H ATOM 2833 1HB LYS B 6 -28.241
34.472 11.226 1.00 0.00 H ATOM 2834 2HB LYS B 6 -29.641 33.423
11.336 1.00 0.00 H ATOM 2835 1HG LYS B 6 -29.498 35.712 9.434 1.00
0.00 H ATOM 2836 2HG LYS B 6 -30.343 35.645 10.981 1.00 0.00 H ATOM
2837 1HD LYS B 6 -31.763 33.748 10.116 1.00 0.00 H ATOM 2838 2HD
LYS B 6 -30.880 33.844 8.600 1.00 0.00 H ATOM 2839 1HE LYS B 6
-31.740 36.167 8.183 1.00 0.00 H ATOM 2840 2HE LYS B 6 -32.610
36.120 9.743 1.00 0.00 H ATOM 2841 1HZ LYS B 6 -33.989 35.514 7.805
1.00 0.00 H ATOM 2842 2HZ LYS B 6 -33.032 34.222 7.532 1.00 0.00 H
ATOM 2843 3HZ LYS B 6 -33.939 34.311 8.889 1.00 0.00 H ATOM 2844 N
VAL B 7 -25.995 32.999 10.051 1.00 0.35 N ATOM 2845 CA VAL B 7
-24.871 32.349 10.651 1.00 0.35 C ATOM 2846 C VAL B 7 -24.592
33.074 11.922 1.00 0.35 C ATOM 2847 O VAL B 7 -24.524 34.302 11.950
1.00 0.35 O ATOM 2848 CB VAL B 7 -23.627 32.383 9.806 1.00 0.35 C
ATOM 2849 CG1 VAL B 7 -23.210 33.847 9.585 1.00 0.35 C ATOM 2850
CG2 VAL B 7 -22.552 31.531 10.499 1.00 0.35 C ATOM 2851 H VAL B 7
-25.821 33.888 9.614 1.00 0.00 H ATOM 2852 HA VAL B 7 -25.120
31.291 10.831 1.00 0.00 H ATOM 2853 HB VAL B 7 -23.863 31.925 8.827
1.00 0.00 H ATOM 2854 1HG1 VAL B 7 -22.471 33.901 8.765 1.00 0.00 H
ATOM 2855 2HG1 VAL B 7 -24.031 34.516 9.285 1.00 0.00 H ATOM 2856
3HG1 VAL B 7 -22.693 34.280 10.456 1.00 0.00 H ATOM 2857 1HG2 VAL B
7 -21.678 31.367 9.847 1.00 0.00 H ATOM 2858 2HG2 VAL B 7 -22.176
32.022 11.412 1.00 0.00 H ATOM 2859 3HG2 VAL B 7 -22.944 30.551
10.791 1.00 0.00 H ATOM 2860 N SER B 8 -24.448 32.318 13.023 1.00
0.17 N ATOM 2861 CA SER B 8 -24.199 32.937 14.287 1.00 0.17 C ATOM
2862 C SER B 8 -22.807 32.592 14.689 1.00 0.17 C ATOM 2863 O SER B
8 -22.347 31.470 14.481 1.00 0.17 O ATOM 2864 CB SER B 8 -25.131
32.446 15.407 1.00 0.17 C ATOM 2865 OG SER B 8 -24.819 33.105
16.625 1.00 0.17 O ATOM 2866 H SER B 8 -24.625 31.319 13.016 1.00
0.00 H ATOM 2867 HA SER B 8 -24.337 34.028 14.216 1.00 0.00 H ATOM
2868 1HB SER B 8 -25.073 31.358 15.536 1.00 0.00 H ATOM 2869 2HB
SER B 8 -26.174 32.697 15.163 1.00 0.00 H ATOM 2870 HG SER B 8
-24.204 32.543 17.125 1.00 0.00 H ATOM 2871 N LEU B 9 -22.092
33.571 15.268 1.00 0.11 N ATOM 2872 CA LEU B 9 -20.747 33.327
15.682 1.00 0.11 C ATOM 2873 C LEU B 9 -20.696 33.497 17.164 1.00
0.11 C ATOM 2874 O LEU B 9 -21.139 34.512 17.700 1.00 0.11 O ATOM
2875 CB LEU B 9 -19.749 34.334 15.080 1.00 0.11 C ATOM 2876 CG LEU
B 9 -18.287 34.121 15.512 1.00 0.11 C ATOM 2877 CD1 LEU B 9 -17.732
32.785 14.988 1.00 0.11 C ATOM 2878 CD2 LEU B 9 -17.418 35.324
15.111 1.00 0.11 C ATOM 2879 H LEU B 9 -22.472 34.471 15.510 1.00
0.00 H ATOM 2880 HA LEU B 9 -20.438 32.317 15.382 1.00 0.00 H ATOM
2881 1HB LEU B 9 -20.066 35.356 15.354 1.00 0.00 H ATOM 2882 2HB
LEU B 9 -19.814 34.285 13.978 1.00 0.00 H ATOM 2883 HG LEU B 9
-18.324 33.885 16.546 1.00 0.00 H ATOM 2884 1HD1 LEU B 9 -16.651
32.745 15.192 1.00 0.00 H ATOM 2885 2HD1 LEU B 9 -18.211 31.936
15.488 1.00 0.00 H ATOM 2886 3HD1 LEU B 9 -17.848 32.744 13.899
1.00 0.00 H ATOM 2887 1HD2 LEU B 9 -16.368 35.176 15.400 1.00 0.00
H ATOM 2888 2HD2 LEU B 9 -17.440 35.449 14.015 1.00 0.00 H ATOM
2889 3HD2 LEU B 9 -17.775 36.256 15.559 1.00 0.00 H ATOM 2890 N ASN
B 10 -20.176 32.478 17.872 1.00 0.17 N ATOM 2891 CA ASN B 10
-20.046 32.599 19.291 1.00 0.17 C ATOM 2892 C ASN B 10 -18.653
32.180 19.623 1.00 0.17 C ATOM 2893 O ASN B 10 -18.240 31.069
19.295 1.00 0.17 O ATOM 2894 CB ASN B 10 -20.992 31.672 20.070 1.00
0.17 C ATOM 2895 CG ASN B 10 -22.415 32.145 19.819 1.00 0.17 C ATOM
2896 OD1 ASN B 10 -23.167 31.505 19.086 1.00 0.17 O ATOM 2897 ND2
ASN B 10 -22.798 33.292 20.443 1.00 0.17 N ATOM 2898 H ASN B 10
-19.879 31.604 17.447 1.00 0.00 H ATOM 2899 HA ASN B 10 -20.331
33.609 19.576 1.00 0.00 H ATOM 2900 1HB ASN B 10 -20.745 31.729
21.143 1.00 0.00 H ATOM 2901 2HB ASN B 10 -20.916 30.627 19.757
1.00 0.00 H ATOM 2902 1HD2 ASN B 10 -22.191 33.807 21.049 1.00 0.00
H ATOM 2903 2HD2 ASN B 10 -23.731 33.618 20.254 1.00 0.00 H ATOM
2904 N PRO B 11 -17.897 33.038 20.245 1.00 0.35 N ATOM 2905 CA PRO
B 11 -18.370 34.356 20.559 1.00 0.35 C ATOM 2906 C PRO B 11 -18.404
35.166 19.305 1.00 0.35 C ATOM 2907 O PRO B 11 -17.867 34.727
18.290 1.00 0.35 O ATOM 2908 CB PRO B 11 -17.403 34.908 21.604 1.00
0.35 C ATOM 2909 CG PRO B 11 -16.865 33.651 22.308 1.00 0.35 C ATOM
2910 CD PRO B 11 -16.938 32.559 21.228 1.00 0.35 C ATOM 2911 HA PRO
B 11 -19.324 34.263 21.103 1.00 0.00 H ATOM 2912 1HB PRO B 11
-17.861 35.651 22.273 1.00 0.00 H ATOM 2913 2HB PRO B 11 -16.571
35.402 21.082 1.00 0.00 H ATOM 2914 1HG PRO B 11 -17.522 33.393
23.155 1.00 0.00 H ATOM 2915 2HG PRO B 11 -15.851 33.769 22.721
1.00 0.00 H ATOM 2916 1HD PRO B 11 -15.961 32.431 20.733 1.00 0.00
H ATOM 2917 2HD PRO B 11 -17.234 31.578 21.626 1.00 0.00 H ATOM
2918 N PRO B 12 -19.030 36.309 19.364 1.00 0.52 N ATOM 2919 CA PRO
B 12 -19.156 37.156 18.209 1.00 0.52 C ATOM 2920 C PRO B 12 -17.853
37.765 17.809 1.00 0.52 C ATOM 2921 O PRO B 12 -17.789 38.365
16.737 1.00 0.52 O ATOM 2922 CB PRO B 12 -20.215 38.194 18.568
1.00 0.52 C ATOM 2923 CG PRO B 12 -21.088 37.480 19.613 1.00 0.52 C
ATOM 2924 CD PRO B 12 -20.128 36.495 20.299 1.00 0.52 C ATOM 2925
HA PRO B 12 -19.493 36.561 17.344 1.00 0.00 H ATOM 2926 1HB PRO B
12 -20.767 38.562 17.689 1.00 0.00 H ATOM 2927 2HB PRO B 12 -19.734
39.074 19.029 1.00 0.00 H ATOM 2928 1HG PRO B 12 -21.889 36.926
19.096 1.00 0.00 H ATOM 2929 2HG PRO B 12 -21.583 38.161 20.323
1.00 0.00 H ATOM 2930 1HD PRO B 12 -19.742 36.914 21.242 1.00 0.00
H ATOM 2931 2HD PRO B 12 -20.663 35.567 20.521 1.00 0.00 H ATOM
2932 N TRP B 13 -16.809 37.635 18.646 1.00 0.35 N ATOM 2933 CA TRP
B 13 -15.559 38.278 18.359 1.00 0.35 C ATOM 2934 C TRP B 13 -15.107
37.850 16.998 1.00 0.35 C ATOM 2935 O TRP B 13 -14.934 36.662
16.731 1.00 0.35 O ATOM 2936 CB TRP B 13 -14.454 37.907 19.361 1.00
0.35 C ATOM 2937 CG TRP B 13 -14.839 38.183 20.795 1.00 0.35 C ATOM
2938 CD1 TRP B 13 -14.961 37.307 21.833 1.00 0.35 C ATOM 2939 CD2
TRP B 13 -15.219 39.470 21.302 1.00 0.35 C ATOM 2940 NE1 TRP B 13
-15.382 37.969 22.961 1.00 0.35 N ATOM 2941 CE2 TRP B 13 -15.549
39.302 22.647 1.00 0.35 C ATOM 2942 CE3 TRP B 13 -15.297 40.691
20.695 1.00 0.35 C ATOM 2943 CZ2 TRP B 13 -15.962 40.356 23.408
1.00 0.35 C ATOM 2944 CZ3 TRP B 13 -15.707 41.756 21.468 1.00 0.35
C ATOM 2945 CH2 TRP B 13 -16.031 41.590 22.798 1.00 0.35 C ATOM
2946 H TRP B 13 -16.882 37.089 19.485 1.00 0.00 H ATOM 2947 HA TRP
B 13 -15.723 39.368 18.375 1.00 0.00 H ATOM 2948 1HB TRP B 13
-13.543 38.459 19.077 1.00 0.00 H ATOM 2949 2HB TRP B 13 -14.206
36.841 19.251 1.00 0.00 H ATOM 2950 HD1 TRP B 13 -14.738 36.249
21.844 1.00 0.00 H ATOM 2951 HE1 TRP B 13 -15.808 37.524 23.741
1.00 0.00 H ATOM 2952 HE3 TRP B 13 -15.044 40.835 19.655 1.00 0.00
H ATOM 2953 HZ2 TRP B 13 -16.229 40.119 24.420 1.00 0.00 H ATOM
2954 HZ3 TRP B 13 -15.795 42.752 21.062 1.00 0.00 H ATOM 2955 HH2
TRP B 13 -16.099 42.501 23.378 1.00 0.00 H ATOM 2956 N ASN B 14
-14.933 38.829 16.085 1.00 0.15 N ATOM 2957 CA ASN B 14 -14.506
38.539 14.747 1.00 0.15 C ATOM 2958 C ASN B 14 -13.076 38.108
14.777 1.00 0.15 C ATOM 2959 O ASN B 14 -12.681 37.185 14.064 1.00
0.15 O ATOM 2960 CB ASN B 14 -14.605 39.739 13.785 1.00 0.15 C ATOM
2961 CG ASN B 14 -13.588 40.802 14.181 1.00 0.15 C ATOM 2962 OD1
ASN B 14 -13.408 41.115 15.357 1.00 0.15 O ATOM 2963 ND2 ASN B 14
-12.882 41.367 13.165 1.00 0.15 N ATOM 2964 H ASN B 14 -15.118
39.805 16.295 1.00 0.00 H ATOM 2965 HA ASN B 14 -15.111 37.712
14.342 1.00 0.00 H ATOM 2966 1HB ASN B 14 -15.612 40.188 13.806
1.00 0.00 H ATOM 2967 2HB ASN B 14 -14.421 39.365 12.763 1.00 0.00
H ATOM 2968 1HD2 ASN B 14 -12.987 41.087 12.202 1.00 0.00 H ATOM
2969 2HD2 ASN B 14 -12.217 42.087 13.380 1.00 0.00 H ATOM 2970 N
ARG B 15 -12.257 38.773 15.615 1.00 0.13 N ATOM 2971 CA ARG B 15
-10.859 38.466 15.668 1.00 0.13 C ATOM 2972 C ARG B 15 -10.645
37.619 16.872 1.00 0.13 C ATOM 2973 O ARG B 15 -11.086 37.958
17.969 1.00 0.13 O ATOM 2974 CB ARG B 15 -9.961 39.702 15.860 1.00
0.13 C ATOM 2975 CG ARG B 15 -9.990 40.695 14.698 1.00 0.13 C ATOM
2976 CD ARG B 15 -9.087 41.910 14.925 1.00 0.13 C ATOM 2977 NE ARG
B 15 -9.233 42.805 13.742 1.00 0.13 N1+ ATOM 2978 CZ ARG B 15
-8.137 43.184 13.023 1.00 0.13 C ATOM 2979 NH1 ARG B 15 -6.892
42.769 13.396 1.00 0.13 N ATOM 2980 NH2 ARG B 15 -8.289 43.984
11.926 1.00 0.13 N ATOM 2981 H ARG B 15 -12.591 39.606 16.079 1.00
0.00 H ATOM 2982 HA ARG B 15 -10.563 37.963 14.736 1.00 0.00 H ATOM
2983 1HB ARG B 15 -8.996 39.350 16.214 1.00 0.00 H ATOM 2984 2HB
ARG B 15 -10.354 40.254 16.738 1.00 0.00 H ATOM 2985 1HG ARG B 15
-11.007 41.090 14.649 1.00 0.00 H ATOM 2986 2HG ARG B 15 -9.785
40.221 13.726 1.00 0.00 H ATOM 2987 1HD ARG B 15 -8.048 41.638
15.153 1.00 0.00 H ATOM 2988 2HD ARG B 15 -9.458 42.433 15.807 1.00
0.00 H ATOM 2989 HE ARG B 15 -9.921 43.526 13.751 1.00 0.00 H ATOM
2990 1HH1 ARG B 15 -6.719 42.203 14.196 1.00 0.00 H ATOM 2991 2HH1
ARG B 15 -6.069 43.121 12.958 1.00 0.00 H ATOM 2992 1HH2 ARG B 15
-7.535 44.013 11.277 1.00 0.00 H ATOM 2993 2HH2 ARG B 15 -9.189
43.955 11.491 1.00 0.00 H ATOM 2994 N ILE B 16 -9.959 36.476 16.699
1.00 0.12 N ATOM 2995 CA ILE B 16 -9.719 35.645 17.838 1.00 0.12 C
ATOM 2996 C ILE B 16 -8.300 35.198 17.781 1.00 0.12 C ATOM 2997 O
ILE B 16 -7.583 35.472 16.820 1.00 0.12 O ATOM 2998 CB ILE B 16
-10.558 34.399 17.883 1.00 0.12 C ATOM 2999 CG1 ILE B 16 -10.236
33.483 16.690 1.00 0.12 C ATOM 3000 CG2 ILE B 16 -12.035 34.818
17.972 1.00 0.12 C ATOM 3001 CD1 ILE B 16 -10.816 32.077 16.840
1.00 0.12 C ATOM 3002 H ILE B 16 -9.589 36.173 15.804 1.00 0.00 H
ATOM 3003 HA ILE B 16 -9.806 36.229 18.761 1.00 0.00 H ATOM 3004 HB
ILE B 16 -10.323 33.855 18.816 1.00 0.00 H ATOM 3005 1HG1 ILE B 16
-9.151 33.372 16.527 1.00 0.00 H ATOM 3006 2HG1 ILE B 16 -10.632
33.939 15.766 1.00 0.00 H ATOM 3007 1HG2 ILE B 16 -12.707 33.959
18.128 1.00 0.00 H ATOM 3008 2HG2 ILE B 16 -12.205 35.507 18.814
1.00 0.00 H ATOM 3009 3HG2 ILE B 16 -12.376 35.323 17.052 1.00 0.00
H ATOM 3010 1HD1 ILE B 16 -10.934 31.593 15.860 1.00 0.00 H ATOM
3011 2HD1 ILE B 16 -10.156 31.437 17.441 1.00 0.00 H ATOM 3012 3HD1
ILE B 16 -11.792 32.108 17.336 1.00 0.00 H ATOM 3013 N PHE B 17
-7.862 34.506 18.848 1.00 0.17 N ATOM 3014 CA PHE B 17 -6.527
33.996 18.904 1.00 0.17 C ATOM 3015 C PHE B 17 -6.595 32.557 18.543
1.00 0.17 C ATOM 3016 O PHE B 17 -7.645 31.923 18.627 1.00 0.17 O
ATOM 3017 CB PHE B 17 -5.886 33.999 20.300 1.00 0.17 C ATOM 3018 CG
PHE B 17 -5.562 35.386 20.720 1.00 0.17 C ATOM 3019 CD1 PHE B 17
-4.468 36.028 20.192 1.00 0.17 C ATOM 3020 CD2 PHE B 17 -6.337
36.026 21.657 1.00 0.17 C ATOM 3021 CE1 PHE B 17 -4.154 37.305
20.585 1.00 0.17 C ATOM 3022 CE2 PHE B 17 -6.027 37.303 22.057 1.00
0.17 C ATOM 3023 CZ PHE B 17 -4.935 37.939 21.518 1.00 0.17 C ATOM
3024 H PHE B 17 -8.467 34.178 19.583 1.00 0.00 H ATOM 3025 HA PHE B
17 -5.913 34.589 18.229 1.00 0.00 H ATOM 3026 1HB PHE B 17 -4.946
33.448 20.184 1.00 0.00 H ATOM 3027 2HB PHE B 17 -6.495 33.466
21.041 1.00 0.00 H ATOM 3028 HD1 PHE B 17 -3.883 35.515 19.440 1.00
0.00 H ATOM 3029 HD2 PHE B 17 -7.205 35.518 22.059 1.00 0.00 H ATOM
3030 HE1 PHE B 17 -3.236 37.726 20.300 1.00 0.00 H ATOM 3031 HE2
PHE B 17 -6.677 37.770 22.777 1.00 0.00 H ATOM 3032 HZ PHE B 17
-4.353 38.631 22.047 1.00 0.00 H ATOM 3033 N LYS B 18 -5.446 32.008
18.119 1.00 0.22 N ATOM 3034 CA LYS B 18 -5.403 30.623 17.781 1.00
0.22 C ATOM 3035 C LYS B 18 -5.558 29.867 19.056 1.00 0.22 C ATOM
3036 O LYS B 18 -5.134 30.320 20.119 1.00 0.22 O ATOM 3037 CB LYS B
18 -4.077 30.203 17.126 1.00 0.22 C ATOM 3038 CG LYS B 18 -2.859
30.461 18.012 1.00 0.22 C ATOM 3039 CD LYS B 18 -1.586 29.780
17.511 1.00 0.22 C ATOM 3040 CE LYS B 18 -0.375 29.996 18.418 1.00
0.22 C ATOM 3041 NZ LYS B 18 0.743 29.138 17.967 1.00 0.22 N1+ ATOM
3042 H LYS B 18 -4.641 32.589 17.925 1.00 0.00 H ATOM 3043 HA LYS B
18 -6.267 30.489 17.128 1.00 0.00 H ATOM 3044 1HB LYS B 18 -3.964
30.718 16.156 1.00 0.00 H ATOM 3045 2HB LYS B 18 -4.150 29.124
16.902 1.00 0.00 H ATOM 3046 1HG LYS B 18 -3.038 30.058 19.019 1.00
0.00 H ATOM 3047 2HG LYS B 18 -2.689 31.546 18.128 1.00 0.00 H ATOM
3048 1HD LYS B 18 -1.354 30.137 16.492 1.00 0.00 H ATOM 3049 2HD
LYS B 18 -1.792 28.698 17.428 1.00 0.00 H ATOM 3050 1HE LYS B 18
-0.596 29.719 19.461 1.00 0.00 H ATOM 3051 2HE LYS B 18 -0.024
31.038 18.411 1.00 0.00 H ATOM 3052 1HZ LYS B 18 1.576 29.272
18.528 1.00 0.00 H ATOM 3053 2HZ LYS B 18 0.522 28.153 18.013 1.00
0.00 H ATOM 3054 3HZ LYS B 18 1.016 29.349 17.015 1.00 0.00 H ATOM
3055 N GLY B 19 -6.207 28.692 18.978 1.00 0.21 N ATOM 3056 CA GLY B
19 -6.383 27.886 20.146 1.00 0.21 C ATOM 3057 C GLY B 19 -7.708
28.214 20.746 1.00 0.21 C ATOM 3058 O GLY B 19 -8.192 27.501 21.623
1.00 0.21 O ATOM 3059 H GLY B 19 -6.495 28.327 18.071 1.00 0.00 H
ATOM 3060 1HA GLY B 19 -5.676 28.245 20.917 1.00 0.00 H ATOM 3061
2HA GLY B 19 -6.080 26.838 20.096 1.00 0.00 H ATOM 3062 N GLU B 20
-8.338 29.306 20.281 1.00 0.23 N ATOM 3063 CA GLU B 20 -9.610
29.665 20.830 1.00 0.23 C ATOM 3064 C GLU B 20 -10.642 28.792
20.202 1.00 0.23 C ATOM 3065 O GLU B 20 -10.428 28.231 19.128 1.00
0.23 O ATOM 3066 CB GLU B 20 -10.002 31.130 20.574 1.00 0.23 C ATOM
3067 CG GLU B 20 -9.106 32.113 21.327 1.00 0.23 C ATOM 3068 CD GLU
B 20 -9.228 31.774 22.806 1.00 0.23 C ATOM 3069 OE1 GLU B 20
-10.378 31.534 23.263 1.00 0.23 O ATOM 3070 OE2 GLU B 20 -8.174
31.735 23.495 1.00 0.23 O1- ATOM 3071 H GLU B 20 -7.903 29.958
19.641 1.00 0.00 H ATOM 3072 HA GLU B 20 -9.596 29.463 21.915 1.00
0.00 H ATOM 3073 1HB GLU B 20 -11.054 31.273 20.883 1.00 0.00 H
ATOM 3074 2HB GLU B 20 -9.998 31.319 19.493 1.00 0.00 H ATOM 3075
1HG GLU B 20 -9.443 33.148 21.165 1.00 0.00 H ATOM 3076 2HG GLU B
20 -8.053 32.040 21.031 1.00 0.00 H ATOM 3077 N ASN B 21 -11.794
28.642 20.879 1.00 0.16 N ATOM 3078 CA ASN B 21 -12.833 27.815
20.346 1.00 0.16 C ATOM 3079 C ASN B 21 -13.814 28.715 19.677 1.00
0.16 C ATOM 3080 O ASN B 21 -14.134 29.792 20.179 1.00 0.16 O ATOM
3081 CB ASN B 21 -13.589 27.007 21.415 1.00 0.16 C ATOM 3082 CG ASN
B 21 -12.613 25.981 21.970 1.00 0.16 C ATOM 3083 OD1 ASN B 21
-11.595 25.692 21.347 1.00 0.16 O ATOM 3084 ND2 ASN B 21 -12.923
25.418 23.168 1.00 0.16 N ATOM 3085 H ASN B 21 -12.005 29.178
21.704 1.00 0.00 H ATOM 3086 HA ASN B 21 -12.376 27.142 19.624 1.00
0.00 H ATOM 3087 1HB ASN B 21 -14.424 26.471 20.932 1.00 0.00 H
ATOM 3088 2HB ASN B 21 -13.999 27.666 22.196 1.00 0.00 H ATOM 3089
1HD2 ASN B 21 -13.739 25.683 23.687 1.00 0.00 H ATOM 3090 2HD2 ASN
B 21 -12.261 24.760 23.540 1.00 0.00 H ATOM 3091 N VAL B 22 -14.289
28.299 18.490 1.00 0.07 N ATOM 3092 CA VAL B 22 -15.243 29.093
17.780 1.00 0.07 C ATOM 3093 C VAL B 22 -16.438 28.234 17.559 1.00
0.07 C ATOM 3094 O VAL B 22 -16.312 27.053 17.236 1.00 0.07 O ATOM
3095 CB VAL B 22 -14.753 29.535 16.431 1.00 0.07 C ATOM 3096 CG1
VAL B 22 -15.891 30.274 15.710 1.00 0.07 C ATOM 3097 CG2 VAL B 22
-13.481 30.379 16.626 1.00 0.07 C ATOM 3098 H VAL B 22 -14.083
27.370 18.135 1.00 0.00 H ATOM 3099 HA VAL B 22 -15.511 29.985
18.368 1.00 0.00 H ATOM 3100 HB VAL B 22 -14.492 28.689 15.799 1.00
0.00 H ATOM 3101 1HG1 VAL B 22 -15.529 30.772 14.795 1.00 0.00 H
ATOM 3102 2HG1 VAL B 22 -16.697 29.591 15.399 1.00 0.00 H ATOM 3103
3HG1 VAL B 22 -16.314 31.040 16.376 1.00 0.00 H ATOM 3104 1HG2 VAL
B 22 -13.124 30.786 15.667 1.00 0.00 H ATOM 3105 2HG2 VAL B 22
-13.699 31.230 17.292 1.00 0.00 H ATOM 3106 3HG2 VAL B 22 -12.657
29.793 17.064 1.00 0.00 H ATOM 3107 N THR B 23 -17.641 28.800
17.762 1.00 0.06 N ATOM 3108 CA THR B 23 -18.823 28.028 17.530 1.00
0.06 C ATOM 3109 C THR B 23 -19.615 28.740 16.486 1.00 0.06 C ATOM
3110 O THR B 23 -19.909 29.927 16.612 1.00 0.06 O ATOM 3111 CB THR
B 23 -19.704 27.891 18.737 1.00 0.06 C ATOM 3112 OG1 THR B 23
-18.992 27.254 19.787 1.00 0.06 O ATOM 3113 CG2 THR B 23 -20.936
27.053 18.353 1.00 0.06 C ATOM 3114 H THR B 23 -17.770 29.719
18.174 1.00 0.00 H ATOM 3115 HA THR B 23 -18.554 27.016 17.215 1.00
0.00 H ATOM 3116 HB THR B 23 -20.030 28.886 19.078 1.00 0.00 H ATOM
3117 HG1 THR B 23 -19.557 27.282 20.569 1.00 0.00 H ATOM 3118 1HG2
THR B 23 -21.569 26.856 19.233 1.00 0.00 H ATOM 3119 2HG2 THR B 23
-21.569 27.557 17.607 1.00 0.00 H ATOM 3120 3HG2 THR B 23 -20.629
26.075 17.945 1.00 0.00 H ATOM 3121 N LEU B 24 -19.967 28.020
15.407 1.00 0.06 N ATOM 3122 CA LEU B 24 -20.752 28.613 14.368 1.00
0.06 C ATOM 3123 C LEU B 24 -22.058 27.900 14.393 1.00 0.06 C ATOM
3124 O LEU B 24 -22.104 26.671 14.388 1.00 0.06 O ATOM 3125 CB LEU
B 24 -20.163 28.405 12.965 1.00 0.06 C ATOM 3126 CG LEU B 24
-18.783 29.062 12.774 1.00 0.06 C ATOM 3127 CD1 LEU B 24 -18.246
28.827 11.352 1.00 0.06 C ATOM 3128 CD2 LEU B 24 -18.814 30.548
13.167 1.00 0.06 C ATOM 3129 H LEU B 24 -19.673 27.055 15.277 1.00
0.00 H ATOM 3130 HA LEU B 24 -20.868 29.681 14.551 1.00 0.00 H ATOM
3131 1HB LEU B 24 -20.876 28.847 12.246 1.00 0.00 H ATOM 3132 2HB
LEU B 24 -20.105 27.329 12.729 1.00 0.00 H ATOM 3133 HG LEU B 24
-18.071 28.564 13.461 1.00 0.00 H ATOM 3134 1HD1 LEU B 24 -17.231
29.242 11.246 1.00 0.00 H ATOM 3135 2HD1 LEU B 24 -18.193 27.751
11.117 1.00 0.00 H ATOM 3136 3HD1 LEU B 24 -18.893 29.306 10.600
1.00 0.00 H ATOM 3137 1HD2 LEU B 24 -17.820 30.978 12.972 1.00 0.00
H ATOM 3138 2HD2 LEU B 24 -19.551 31.110 12.571 1.00 0.00 H ATOM
3139 3HD2 LEU B 24 -19.058 30.667 14.225 1.00 0.00 H ATOM 3140 N
THR B 25 -23.167 28.659 14.441 1.00 0.28 N ATOM 3141 CA THR B 25
-24.439 28.009 14.453 1.00 0.28 C ATOM 3142 C THR B 25 -25.210
28.557 13.308 1.00 0.28 C ATOM 3143 O THR B 25 -25.220 29.760
13.059 1.00 0.28 O ATOM 3144 CB THR B 25 -25.235 28.276 15.697 1.00
0.28 C ATOM 3145 OG1 THR B 25 -24.523 27.828 16.841 1.00 0.28 O
ATOM 3146 CG2 THR B 25 -26.580 27.539 15.588 1.00 0.28 C ATOM 3147
H THR B 25 -23.128 29.672 14.385 1.00 0.00 H ATOM 3148 HA THR B 25
-24.321 26.920 14.354 1.00 0.00 H ATOM 3149 HB THR B 25 -25.448
29.352 15.810 1.00 0.00 H ATOM 3150 HG1 THR B 25 -23.678 28.304
16.823 1.00 0.00 H ATOM 3151 1HG2 THR B 25 -27.114 27.581 16.552
1.00 0.00 H ATOM 3152 2HG2 THR B 25 -27.247 27.990 14.837 1.00 0.00
H ATOM 3153 3HG2 THR B 25 -26.441 26.473 15.342 1.00 0.00 H ATOM
3154 N CYS B 26 -25.878 27.669 12.565 1.00 0.52 N ATOM 3155 CA CYS
B 26 -26.616 28.143 11.446 1.00 0.52 C ATOM 3156 C CYS B 26 -28.050
27.883 11.751 1.00 0.52 C ATOM 3157 O CYS B 26 -28.460 26.734
11.908 1.00 0.52 O ATOM 3158 CB CYS B 26 -26.230 27.356 10.198 1.00
0.52 C ATOM 3159 SG CYS B 26 -27.098 27.867 8.709 1.00 0.52 S ATOM
3160 H CYS B 26 -25.872 26.670 12.726 1.00 0.00 H ATOM 3161 HA CYS
B 26 -26.399 29.195 11.235 1.00 0.00 H ATOM 3162 1HB CYS B 26
-26.355 26.271 10.346 1.00 0.00 H ATOM 3163 2HB CYS B 26 -25.174
27.547 10.007 1.00 0.00 H ATOM 3164 N ASN B 27 -28.853 28.959
11.836 1.00 0.35 N ATOM 3165 CA ASN B 27 -30.232 28.793 12.176 1.00
0.35 C ATOM 3166 C ASN B 27 -31.043 29.100 10.964 1.00 0.35 C ATOM
3167 O ASN B 27 -30.620 29.856 10.092 1.00 0.35 O ATOM 3168 CB ASN
B 27 -30.713 29.749 13.280 1.00 0.35 C ATOM 3169 CG ASN B 27
-30.594 31.169 12.743 1.00 0.35 C ATOM 3170 OD1 ASN B 27 -29.551
31.568 12.228 1.00 0.35 O ATOM 3171 ND2 ASN B 27 -31.698 31.954
12.855 1.00 0.35 N ATOM 3172 H ASN B 27 -28.543 29.920 11.683 1.00
0.00 H ATOM 3173 HA ASN B 27 -30.415 27.767 12.532 1.00 0.00 H ATOM
3174 1HB ASN B 27 -30.081 29.665 14.180 1.00 0.00 H ATOM 3175 2HB
ASN B 27 -31.746 29.482 13.557 1.00 0.00 H ATOM 3176 1HD2 ASN B 27
-32.530 31.636 13.316 1.00 0.00 H ATOM 3177 2HD2 ASN B 27 -31.598
32.913 12.574 1.00 0.00 H ATOM 3178 N GLY B 28 -32.237 28.485
10.876 1.00 0.15 N ATOM 3179 CA GLY B 28 -33.101 28.725 9.762 1.00
0.15 C ATOM 3180 C GLY B 28 -33.969 27.521 9.623 1.00 0.15 C ATOM
3181 O GLY B 28 -33.839 26.561 10.382 1.00 0.15 O ATOM 3182 H GLY B
28 -32.528 27.749 11.502 1.00 0.00 H ATOM 3183 1HA GLY B 28 -32.514
28.852 8.837 1.00 0.00 H ATOM 3184 2HA GLY B 28 -33.710 29.632
9.918 1.00 0.00 H ATOM 3185 N ASN B 29 -34.882 27.537 8.633 1.00
0.16 N ATOM 3186 CA ASN B 29 -35.730 26.399 8.454 1.00 0.16 C ATOM
3187 C ASN B 29 -34.852 25.276 8.021 1.00 0.16 C ATOM 3188 O ASN B
29 -33.866 25.478 7.315 1.00 0.16 O ATOM 3189 CB ASN B 29 -36.820
26.580 7.382 1.00 0.16 C ATOM 3190 CG ASN B 29 -37.876 27.535 7.919
1.00 0.16 C ATOM 3191 OD1 ASN B 29 -37.878 27.893 9.096 1.00 0.16 O
ATOM 3192 ND2 ASN B 29 -38.816 27.949 7.029 1.00 0.16 N ATOM 3193 H
ASN B 29 -35.006 28.318 8.013 1.00 0.00 H ATOM 3194 HA ASN B 29
-36.207 26.143 9.419 1.00 0.00 H ATOM 3195 1HB ASN B 29 -37.363
25.641 7.240 1.00 0.00 H ATOM 3196 2HB ASN B 29 -36.417 26.982
6.449 1.00 0.00 H ATOM 3197 1HD2 ASN B 29 -38.833 27.631 6.078 1.00
0.00 H ATOM 3198 2HD2 ASN B 29 -39.532 28.562 7.380 1.00 0.00 H
ATOM 3199 N ASN B 30 -35.187 24.051 8.463 1.00 0.16 N ATOM 3200 CA
ASN B 30 -34.377 22.921 8.127 1.00 0.16 C ATOM 3201 C ASN B 30
-35.268 21.823 7.645 1.00 0.16 C ATOM 3202 O ASN B 30 -36.420
21.713 8.060 1.00 0.16 O ATOM 3203 CB ASN B 30 -33.609 22.375 9.339
1.00 0.16 C ATOM 3204 CG ASN B 30 -32.795 21.178 8.886 1.00 0.16 C
ATOM 3205 OD1 ASN B 30 -32.210 21.159 7.805 1.00 0.16 O ATOM 3206
ND2 ASN B 30 -32.781 20.126 9.746 1.00 0.16 N ATOM 3207 H ASN B 30
-36.004 23.852 9.015 1.00 0.00 H ATOM 3208 HA ASN B 30 -33.660
23.196 7.338 1.00 0.00 H
ATOM 3209 1HB ASN B 30 -34.307 22.117 10.152 1.00 0.00 H ATOM 3210
2HB ASN B 30 -32.904 23.133 9.720 1.00 0.00 H ATOM 3211 1HD2 ASN B
30 -33.323 20.099 10.587 1.00 0.00 H ATOM 3212 2HD2 ASN B 30
-32.195 19.340 9.478 1.00 0.00 H ATOM 3213 N PHE B 31 -34.745
20.987 6.724 1.00 0.12 N ATOM 3214 CA PHE B 31 -35.486 19.863 6.236
1.00 0.12 C ATOM 3215 C PHE B 31 -35.228 18.765 7.212 1.00 0.12 C
ATOM 3216 O PHE B 31 -34.243 18.805 7.945 1.00 0.12 O ATOM 3217 CB
PHE B 31 -35.024 19.385 4.850 1.00 0.12 C ATOM 3218 CG PHE B 31
-35.870 18.225 4.458 1.00 0.12 C ATOM 3219 CD1 PHE B 31 -37.137
18.422 3.958 1.00 0.12 C ATOM 3220 CD2 PHE B 31 -35.395 16.940
4.581 1.00 0.12 C ATOM 3221 CE1 PHE B 31 -37.919 17.353 3.589 1.00
0.12 C ATOM 3222 CE2 PHE B 31 -36.173 15.867 4.215 1.00 0.12 C ATOM
3223 CZ PHE B 31 -37.439 16.073 3.720 1.00 0.12 C ATOM 3224 H PHE B
31 -33.732 20.891 6.678 1.00 0.00 H ATOM 3225 HA PHE B 31 -36.560
20.108 6.225 1.00 0.00 H ATOM 3226 1HB PHE B 31 -33.955 19.120
4.883 1.00 0.00 H ATOM 3227 2HB PHE B 31 -35.127 20.202 4.121 1.00
0.00 H ATOM 3228 HD1 PHE B 31 -37.521 19.428 3.830 1.00 0.00 H ATOM
3229 HD2 PHE B 31 -34.399 16.800 4.975 1.00 0.00 H ATOM 3230 HE1
PHE B 31 -38.916 17.520 3.188 1.00 0.00 H ATOM 3231 HE2 PHE B 31
-35.783 14.857 4.316 1.00 0.00 H ATOM 3232 HZ PHE B 31 -38.053
15.224 3.428 1.00 0.00 H ATOM 3233 N PHE B 32 -36.111 17.753 7.268
1.00 0.11 N ATOM 3234 CA PHE B 32 -35.851 16.728 8.229 1.00 0.11 C
ATOM 3235 C PHE B 32 -34.911 15.762 7.598 1.00 0.11 C ATOM 3236 O
PHE B 32 -35.322 14.780 6.982 1.00 0.11 O ATOM 3237 CB PHE B 32
-37.114 15.971 8.670 1.00 0.11 C ATOM 3238 CG PHE B 32 -37.971
16.991 9.336 1.00 0.11 C ATOM 3239 CD1 PHE B 32 -38.800 17.790
8.583 1.00 0.11 C ATOM 3240 CD2 PHE B 32 -37.941 17.160 10.700 1.00
0.11 C ATOM 3241 CE1 PHE B 32 -39.597 18.739 9.178 1.00 0.11 C ATOM
3242 CE2 PHE B 32 -38.735 18.108 11.300 1.00 0.11 C ATOM 3243 CZ
PHE B 32 -39.564 18.899 10.542 1.00 0.11 C ATOM 3244 H PHE B 32
-36.832 17.591 6.586 1.00 0.00 H ATOM 3245 HA PHE B 32 -35.409
17.166 9.143 1.00 0.00 H ATOM 3246 1HB PHE B 32 -36.811 15.166
9.358 1.00 0.00 H ATOM 3247 2HB PHE B 32 -37.630 15.498 7.820 1.00
0.00 H ATOM 3248 HD1 PHE B 32 -38.864 17.652 7.507 1.00 0.00 H ATOM
3249 HD2 PHE B 32 -37.287 16.539 11.307 1.00 0.00 H ATOM 3250 HE1
PHE B 32 -40.252 19.360 8.572 1.00 0.00 H ATOM 3251 HE2 PHE B 32
-38.706 18.233 12.380 1.00 0.00 H ATOM 3252 HZ PHE B 32 -40.190
19.649 11.019 1.00 0.00 H ATOM 3253 N GLU B 33 -33.600 16.034 7.738
1.00 0.10 N ATOM 3254 CA GLU B 33 -32.616 15.164 7.171 1.00 0.10 C
ATOM 3255 C GLU B 33 -31.455 15.127 8.108 1.00 0.10 C ATOM 3256 O
GLU B 33 -31.273 16.029 8.926 1.00 0.10 O ATOM 3257 CB GLU B 33
-32.084 15.638 5.809 1.00 0.10 C ATOM 3258 CG GLU B 33 -31.401
17.006 5.863 1.00 0.10 C ATOM 3259 CD GLU B 33 -30.934 17.340 4.456
1.00 0.10 C ATOM 3260 OE1 GLU B 33 -30.393 16.424 3.782 1.00 0.10 O
ATOM 3261 OE2 GLU B 33 -31.113 18.515 4.035 1.00 0.10 O1- ATOM 3262
H GLU B 33 -33.258 16.896 8.139 1.00 0.00 H ATOM 3263 HA GLU B 33
-33.037 14.148 7.082 1.00 0.00 H ATOM 3264 1HB GLU B 33 -32.872
15.591 5.047 1.00 0.00 H ATOM 3265 2HB GLU B 33 -31.344 14.879
5.494 1.00 0.00 H ATOM 3266 1HG GLU B 33 -30.551 16.931 6.547 1.00
0.00 H ATOM 3267 2HG GLU B 33 -32.064 17.799 6.243 1.00 0.00 H ATOM
3268 N VAL B 34 -30.644 14.058 8.020 1.00 0.09 N ATOM 3269 CA VAL B
34 -29.511 13.941 8.884 1.00 0.09 C ATOM 3270 C VAL B 34 -28.559
15.048 8.570 1.00 0.09 C ATOM 3271 O VAL B 34 -28.077 15.734 9.470
1.00 0.09 O ATOM 3272 CB VAL B 34 -28.792 12.637 8.712 1.00 0.09 C
ATOM 3273 CG1 VAL B 34 -27.594 12.606 9.674 1.00 0.09 C ATOM 3274
CG2 VAL B 34 -29.797 11.497 8.948 1.00 0.09 C ATOM 3275 H VAL B 34
-30.815 13.314 7.366 1.00 0.00 H ATOM 3276 HA VAL B 34 -29.835
14.056 9.932 1.00 0.00 H ATOM 3277 HB VAL B 34 -28.403 12.546 7.681
1.00 0.00 H ATOM 3278 1HG1 VAL B 34 -27.078 11.632 9.646 1.00 0.00
H ATOM 3279 2HG1 VAL B 34 -26.840 13.370 9.421 1.00 0.00 H ATOM
3280 3HG1 VAL B 34 -27.914 12.776 10.716 1.00 0.00 H ATOM 3281 1HG2
VAL B 34 -29.295 10.514 8.942 1.00 0.00 H ATOM 3282 2HG2 VAL B 34
-30.288 11.600 9.931 1.00 0.0.0 H ATOM 3283 3HG2 VAL B 34 -30.583
11.448 8.178 1.00 0.00 H ATOM 3284 N SER B 35 -28.277 15.279 7.274
1.00 0.11 N ATOM 3285 CA SER B 35 -27.364 16.335 6.942 1.00 0.11 C
ATOM 3286 C SER B 35 -28.183 17.559 6.696 1.00 0.11 C ATOM 3287 O
SER B 35 -28.493 17.913 5.559 1.00 0.11 O ATOM 3288 CB SER B 35
-26.512 16.040 5.689 1.00 0.11 C ATOM 3289 OG SER B 35 -27.339
15.843 4.552 1.00 0.11 O ATOM 3290 H SER B 35 -28.722 14.814 6.501
1.00 0.00 H ATOM 3291 HA SER B 35 -26.655 16.496 7.772 1.00 0.00 H
ATOM 3292 1HB SER B 35 -25.922 15.124 5.827 1.00 0.00 H ATOM 3293
2HB SER B 35 -25.813 16.882 5.528 1.00 0.00 H ATOM 3294 HG SER B 35
-27.978 16.589 4.533 1.00 0.00 H ATOM 3295 N SER B 36 -28.548
18.243 7.794 1.00 0.27 N ATOM 3296 CA SER B 36 -29.398 19.394 7.742
1.00 0.27 C ATOM 3297 C SER B 36 -28.707 20.528 7.057 1.00 0.27 C
ATOM 3298 O SER B 36 -29.282 21.190 6.194 1.00 0.27 O ATOM 3299 CB
SER B 36 -29.776 19.889 9.147 1.00 0.27 C ATOM 3300 OG SER B 36
-30.410 18.846 9.871 1.00 0.27 O ATOM 3301 H SER B 36 -28.475
17.775 8.692 1.00 0.00 H ATOM 3302 HA SER B 36 -30.315 19.170 7.176
1.00 0.00 H ATOM 3303 1HB SER B 36 -30.346 20.826 9.116 1.00 0.00 H
ATOM 3304 2HB SER B 36 -28.841 20.156 9.675 1.00 0.00 H ATOM 3305
HG SER B 36 -30.330 19.061 10.811 1.00 0.00 H ATOM 3306 N THR B 37
-27.431 20.777 7.399 1.00 0.48 N ATOM 3307 CA THR B 37 -26.842
21.964 6.858 1.00 0.48 C ATOM 3308 C THR B 37 -25.567 21.675 6.148
1.00 0.48 C ATOM 3309 O THR B 37 -24.911 20.660 6.377 1.00 0.48 O
ATOM 3310 CB THR B 37 -26.522 22.984 7.901 1.00 0.48 C ATOM 3311
OG1 THR B 37 -25.965 24.129 7.283 1.00 0.48 O ATOM 3312 CG2 THR B
37 -25.515 22.381 8.896 1.00 0.48 C ATOM 3313 H THR B 37 -26.848
20.135 7.907 1.00 0.00 H ATOM 3314 HA THR B 37 -27.514 22.445 6.132
1.00 0.00 H ATOM 3315 HB THR B 37 -27.418 23.228 8.460 1.00 0.00 H
ATOM 3316 HG1 THR B 37 -25.716 24.744 7.987 1.00 0.00 H ATOM 3317
1HG2 THR B 37 -25.307 23.154 9.649 1.00 0.00 H ATOM 3318 2HG2 THR B
37 -25.923 21.495 9.398 1.00 0.00 H ATOM 3319 3HG2 THR B 37 -24.557
22.126 8.418 1.00 0.00 H ATOM 3320 N LYS B 38 -25.205 22.598 5.235
1.00 0.41 N ATOM 3321 CA LYS B 38 -23.972 22.506 4.517 1.00 0.41 C
ATOM 3322 C LYS B 38 -23.171 23.683 4.969 1.00 0.41 C ATOM 3323 O
LYS B 38 -23.687 24.798 5.054 1.00 0.41 O ATOM 3324 CB LYS B 38
-24.131 22.656 2.995 1.00 0.41 C ATOM 3325 CG LYS B 38 -25.186
21.731 2.385 1.00 0.41 C ATOM 3326 CD LYS B 38 -26.617 22.138 2.751
1.00 0.41 C ATOM 3327 CE LYS B 38 -27.700 21.373 1.986 1.00 0.41 C
ATOM 3328 NZ LYS B 38 -29.037 21.900 2.348 1.00 0.41 N1+ ATOM 3329
H LYS B 38 -25.630 23.518 5.314 1.00 0.00 H ATOM 3330 HA LYS B 38
-23.477 21.547 4.738 1.00 0.00 H ATOM 3331 1HB LYS B 38 -23.141
22.476 2.541 1.00 0.00 H ATOM 3332 2HB LYS B 38 -24.408 23.693
2.761 1.00 0.00 H ATOM 3333 1HG LYS B 38 -24.996 20.683 2.681 1.00
0.00 H ATOM 3334 2HG LYS B 38 -25.082 21.760 1.285 1.00 0.00 H ATOM
3335 1HD LYS B 38 -26.726 23.208 2.649 1.00 0.00 H ATOM 3336 2HD
LYS B 38 -26.849 21.891 3.795 1.00 0.00 H ATOM 3337 1HE LYS B 38
-27.684 20.301 2.244 1.00 0.00 H ATOM 3338 2HE LYS B 38 -27.598
21.468 0.893 1.00 0.00 H ATOM 3339 1HZ LYS B 38 -29.782 21.422
1.855 1.00 0.00 H ATOM 3340 2HZ LYS B 38 -29.227 21.774 3.336 1.00
0.00 H ATOM 3341 3HZ LYS B 38 -29.137 22.884 2.132 1.00 0.00 H ATOM
3342 N TRP B 39 -21.884 23.465 5.297 1.00 0.18 N ATOM 3343 CA TRP B
39 -21.073 24.572 5.707 1.00 0.18 C ATOM 3344 C TRP B 39 -20.040
24.787 4.659 1.00 0.18 C ATOM 3345 O TRP B 39 -19.565 23.841 4.034
1.00 0.18 O ATOM 3346 CB TRP B 39 -20.331 24.376 7.044 1.00 0.18 C
ATOM 3347 CG TRP B 39 -21.211 24.487 8.268 1.00 0.18 C ATOM 3348
CD1 TRP B 39 -21.745 23.516 9.062 1.00 0.18 C ATOM 3349 CD2 TRP B
39 -21.658 25.743 8.802 1.00 0.18 C ATOM 3350 NE1 TRP B 39 -22.498
24.090 10.062 1.00 0.18 N ATOM 3351 CE2 TRP B 39 -22.453 25.461
9.912 1.00 0.18 C ATOM 3352 CE3 TRP B 39 -21.425 27.026 8.397 1.00
0.18 C ATOM 3353 CZ2 TRP B 39 -23.031 26.465 10.636 1.00 0.18 C
ATOM 3354 CZ3 TRP B 39 -22.006 28.036 9.130 1.00 0.18 C ATOM 3355
CH2 TRP B 39 -22.793 27.761 10.228 1.00 0.18 C ATOM 3356 H TRP B 39
-21.423 22.572 5.234 1.00 0.00 H ATOM 3357 HA TRP B 39 -21.686
25.480 5.806 1.00 0.00 H ATOM 3358 1HB TRP B 39 -19.541 25.146
7.108 1.00 0.00 H ATOM 3359 2HB TRP B 39 -19.802 23.412 7.047 1.00
0.00 H ATOM 3360 HD1 TRP B 39 -21.773 22.453 8.874 1.00 0.00 H ATOM
3361 HE1 TRP B 39 -23.076 23.572 10.695 1.00 0.00 H ATOM 3362 HE3
TRP B 39 -20.762 27.244 7.571 1.00 0.00 H ATOM 3363 HZ2 TRP B 39
-23.620 26.247 11.520 1.00 0.00 H ATOM 3364 HZ3 TRP B 39 -21.828
29.070 8.842 1.00 0.00 H ATOM 3365 HH2 TRP B 39 -23.235 28.564
10.806 1.00 0.00 H ATOM 3366 N PHE B 40 -19.690 26.063 4.416 1.00
0.08 N ATOM 3367 CA PHE B 40 -18.688 26.328 3.434 1.00 0.08 C ATOM
3368 C PHE B 40 -17.664 27.212 4.057 1.00 0.08 C ATOM 3369 O PHE B
40 -17.990 28.127 4.811 1.00 0.08 O ATOM 3370 CB PHE B 40 -19.229
27.050 2.190 1.00 0.08 C ATOM 3371 CG PHE B 40 -20.153 26.100 1.514
1.00 0.08 C ATOM 3372 CD1 PHE B 40 -21.465 25.994 1.916 1.00 0.08 C
ATOM 3373 CD2 PHE B 40 -19.703 25.313 0.478 1.00 0.08 C ATOM 3374
CE1 PHE B 40 -22.315 25.114 1.291 1.00 0.08 C ATOM 3375 CE2 PHE B
40 -20.551 24.431 -0.150 1.00 0.08 C ATOM 3376 CZ PHE B 40 -21.860
24.332 0.257 1.00 0.08 C ATOM 3377 H PHE B 40 -20.105 26.853 4.892
1.00 0.00 H ATOM 3378 HA PHE B 40 -18.309 25.372 3.136 1.00 0.00 H
ATOM 3379 1HB PHE B 40 -18.376 27.311 1.549 1.00 0.00 H ATOM 3380
2HB PHE B 40 -19.730 27.984 2.471 1.00 0.00 H ATOM 3381 HD1 PHE B
40 -21.845 26.623 2.717 1.00 0.00 H ATOM 3382 HD2 PHE B 40 -18.680
25.415 0.131 1.00 0.00 H ATOM 3383 HE1 PHE B 40 -23.355 25.087
1.589 1.00 0.00 H ATOM 3384 HE2 PHE B 40 -20.212 23.880 -1.022 1.00
0.00 H ATOM 3385 HZ PHE B 40 -22.535 23.650 -0.252 1.00 0.00 H ATOM
3386 N HIS B 41 -16.383 26.921 3.777 1.00 0.10 N ATOM 3387 CA HIS B
41 -15.322 27.757 4.242 1.00 0.10 C ATOM 3388 C HIS B 41 -14.620
28.223 3.014 1.00 0.10 C ATOM 3389 O HIS B 41 -14.100 27.419 2.242
1.00 0.10 O ATOM 3390 CB HIS B 41 -14.287 27.030 5.109 1.00 0.10 C
ATOM 3391 CG HIS B 41 -13.274 27.973 5.682 1.00 0.10 C ATOM 3392
ND1 HIS B 41 -12.236 27.588 6.499 1.00 0.10 N ATOM 3393 CD2 HIS B
41 -13.159 29.322 5.541 1.00 0.10 C ATOM 3394 CE1 HIS B 41 -11.548
28.715 6.810 1.00 0.10 C ATOM 3395 NE2 HIS B 41 -12.071 29.794
6.253 1.00 0.10 N ATOM 3396 H HIS B 41 -16.137 26.064 3.279 1.00
0.00 H ATOM 3397 HA HIS B 41 -15.740 28.586 4.831 1.00 0.00 H ATOM
3398 1HB HIS B 41 -13.799 26.218 4.545 1.00 0.00 H ATOM 3399 2HB
HIS B 41 -14.824 26.533 5.938 1.00 0.00 H ATOM 3400 HD2 HIS B 41
-13.745 30.040 5.019 1.00 0.00 H ATOM 3401 HE1 HIS B 41 -10.615
28.670 7.349 1.00 0.00 H ATOM 3402 HE2 HIS B 41 -11.766 30.724
6.456 1.00 0.00 H ATOM 3403 N ASN B 42 -14.593 29.547 2.797 1.00
0.11 N ATOM 3404 CA ASN B 42 -13.967 30.065 1.622 1.00 0.11 C ATOM
3405 C ASN B 42 -14.617 29.423 0.440 1.00 0.11 C ATOM 3406 O ASN B
42 -14.003 29.264 -0.614 1.00 0.11 O ATOM 3407 CB ASN B 42 -12.450
29.807 1.562 1.00 0.11 C ATOM 3408 CG ASN B 42 -11.781 30.743 2.558
1.00 0.11 C ATOM 3409 OD1 ASN B 42 -12.427 31.620 3.129 1.00 0.11 O
ATOM 3410 ND2 ASN B 42 -10.447 30.568 2.758 1.00 0.11 N ATOM 3411 H
ASN B 42 -14.895 30.202 3.517 1.00 0.00 H ATOM 3412 HA ASN B 42
-14.186 31.144 1.529 1.00 0.00 H ATOM 3413 1HB ASN B 42 -12.064
30.095 0.568 1.00 0.00 H ATOM 3414 2HB ASN B 42 -12.163 28.762
1.744 1.00 0.00 H ATOM 3415 1HD2 ASN B 42 -9.941 29.816 2.328 1.00
0.00 H ATOM 3416 2HD2 ASN B 42 -9.999 31.137 3.458 1.00 0.00 H ATOM
3417 N GLY B 43 -15.899 29.045 0.589 1.00 0.08 N ATOM 3418 CA GLY B
43 -16.624 28.488 -0.515 1.00 0.08 C ATOM 3419 C GLY B 43 -16.364
27.018 -0.611 1.00 0.08 C ATOM 3420 O GLY B 43 -16.830 26.369
-1.546 1.00 0.08 O ATOM 3421 H GLY B 43 -16.266 28.914 1.519 1.00
0.00 H ATOM 3422 1HA GLY B 43 -16.323 28.969 -1.458 1.00 0.00 H
ATOM 3423 2HA GLY B 43 -17.706 28.635 -0.374 1.00 0.00 H ATOM 3424
N SER B 44 -15.617 26.438 0.346 1.00 0.15 N ATOM 3425 CA SER B 44
-15.375 25.028 0.255 1.00 0.15 C ATOM 3426 C SER B 44 -16.345
24.356 1.167 1.00 0.15 C ATOM 3427 O SER B 44 -16.513 24.755 2.317
1.00 0.15 O ATOM 3428 CB SER B 44 -13.964 24.604 0.694 1.00 0.15 C
ATOM 3429 OG SER B 44 -13.788 24.860 2.080 1.00 0.15 O ATOM 3430 H
SER B 44 -15.082 26.974 1.012 1.00 0.00 H ATOM 3431 HA SER B 44
-15.486 24.690 -0.788 1.00 0.00 H ATOM 3432 1HB SER B 44 -13.183
25.094 0.087 1.00 0.00 H ATOM 3433 2HB SER B 44 -13.867 23.517
0.561 1.00 0.00 H ATOM 3434 HG SER B 44 -13.580 25.804 2.177 1.00
0.00 H ATOM 3435 N LEU B 45 -17.025 23.310 0.666 1.00 0.35 N ATOM
3436 CA LEU B 45 -17.997 22.626 1.465 1.00 0.35 C ATOM 3437 C LEU B
45 -17.255 21.852 2.504 1.00 0.35 C ATOM 3438 O LEU B 45 -16.195
21.288 2.241 1.00 0.35 O ATOM 3439 CB LEU B 45 -18.886 21.676 0.622
1.00 0.35 C ATOM 3440 CG LEU B 45 -20.000 20.880 1.345 1.00 0.35 C
ATOM 3441 CD1 LEU B 45 -20.847 20.099 0.328 1.00 0.35 C ATOM 3442
CD2 LEU B 45 -19.465 19.928 2.433 1.00 0.35 C ATOM 3443 H LEU B 45
-16.840 22.935 -0.247 1.00 0.00 H ATOM 3444 HA LEU B 45 -18.651
23.382 1.916 1.00 0.00 H ATOM 3445 1HB LEU B 45 -18.218 20.935
0.143 1.00 0.00 H ATOM 3446 2HB LEU B 45 -19.327 22.235 -0.212 1.00
0.00 H ATOM 3447 HG LEU B 45 -20.665 21.614 1.840 1.00 0.00 H ATOM
3448 1HD1 LEU B 45 -21.676 19.564 0.821 1.00 0.00 H ATOM 3449 2HD1
LEU B 45 -21.291 20.767 -0.428 1.00 0.00 H ATOM 3450 3HD1 LEU B 45
-20.234 19.352 -0.203 1.00 0.00 H ATOM 3451 1HD2 LEU B 45 -19.720
18.886 2.158 1.00 0.00 H ATOM 3452 2HD2 LEU B 45 -18.389 19.861
2.575 1.00 0.00 H ATOM 3453 3HD2 LEU B 45 -20.074 20.108 3.311 1.00
0.00 H ATOM 3454 N SER B 46 -17.808 21.826 3.734 1.00 0.48 N ATOM
3455 CA SER B 46 -17.218 21.081 4.809 1.00 0.48 C ATOM 3456 C SER B
46 -18.124 19.925 5.078 1.00 0.48 C ATOM 3457 O SER B 46 -19.320
20.095 5.301 1.00 0.48 O ATOM 3458 CB SER B 46 -17.159 21.829 6.154
1.00 0.48 C ATOM 3459 OG SER B 46 -16.268 22.929 6.093 1.00 0.48 O
ATOM 3460 H SER B 46 -18.582 22.438 3.972 1.00 0.00 H ATOM 3461 HA
SER B 46 -16.185 20.797 4.554 1.00 0.00 H ATOM 3462 1HB SER B 46
-16.623 21.080 6.739 1.00 0.00 H ATOM 3463 2HB SER B 46 -18.133
22.087 6.591 1.00 0.00 H ATOM 3464 HG SER B 46 -16.007 23.091 7.021
1.00 0.00 H ATOM 3465 N GLU B 47 -17.561 18.708 5.029 1.00 0.44 N
ATOM 3466 CA GLU B 47 -18.248 17.483 5.316 1.00 0.44 C ATOM 3467 C
GLU B 47 -18.453 17.380 6.797 1.00 0.44 C ATOM 3468 O GLU B 47
-19.343 16.678 7.271 1.00 0.44 O ATOM 3469 CB GLU B 47 -17.440
16.244 4.906 1.00 0.44 C ATOM 3470 CG GLU B 47 -16.115 16.136 5.662
1.00 0.44 C ATOM 3471 CD GLU B 47 -15.396 14.878 5.203 1.00 0.44 C
ATOM 3472 OE1 GLU B 47 -15.858 14.260 4.206 1.00 0.44 O ATOM 3473
OE2 GLU B 47 -14.373 14.517 5.844 1.00 0.44 O1- ATOM 3474 H GLU B
47 -16.607 18.583 4.722 1.00 0.00 H ATOM 3475 HA GLU B 47 -19.239
17.485 4.833 1.00 0.00 H ATOM 3476 1HB GLU B 47 -17.273 16.281
3.815 1.00 0.00 H ATOM 3477 2HB GLU B 47 -18.068 15.358 5.110 1.00
0.00 H ATOM 3478 1HG GLU B 47 -16.248 16.052 6.752 1.00 0.00 H ATOM
3479 2HG GLU B 47 -15.450 16.998 5.494 1.00 0.00 H ATOM 3480 N GLU
B 48 -17.608 18.100 7.551 1.00 0.45 N ATOM 3481 CA GLU B 48 -17.419
17.985 8.969 1.00 0.45 C ATOM 3482 C GLU B 48 -18.648 18.126 9.823
1.00 0.45 C ATOM 3483 O GLU B 48 -18.857 17.287 10.697 1.00 0.45 O
ATOM 3484 CB GLU B 48 -16.414 19.033 9.468 1.00 0.45 C ATOM 3485 CG
GLU B 48 -16.862 20.463 9.154 1.00 0.45 C ATOM 3486 CD GLU B 48
-15.749 21.419 9.560 1.00 0.45 C ATOM 3487 OE1 GLU B 48 -14.717
20.938 10.099 1.00 0.45 O ATOM 3488 OE2 GLU B 48 -15.917 22.647
9.333 1.00 0.45 O1- ATOM 3489 H GLU B 48 -16.949 18.691 7.075 1.00
0.00 H ATOM 3490 HA GLU B 48 -17.016 16.981 9.188 1.00 0.00 H ATOM
3491 1HB GLU B 48 -15.437 18.814 8.999 1.00 0.00 H ATOM 3492 2HB
GLU B 48 -16.290 18.894 10.557 1.00 0.00 H ATOM 3493 1HG GLU B 48
-17.656 20.717 9.869 1.00 0.00 H ATOM 3494 2HG GLU B 48 -17.412
20.608 8.238 1.00 0.00 H ATOM 3495 N THR B 49 -19.523 19.131 9.626
1.00 0.55 N ATOM 3496 CA THR B 49 -20.475 19.275 10.695 1.00 0.55 C
ATOM 3497 C THR B 49 -21.869 19.563 10.218 1.00 0.55 C ATOM 3498 O
THR B 49
-22.124 19.788 9.036 1.00 0.55 O ATOM 3499 CB THR B 49 -20.062
20.399 11.603 1.00 0.55 C ATOM 3500 OG1 THR B 49 -20.882 20.478
12.757 1.00 0.55 O ATOM 3501 CG2 THR B 49 -20.139 21.702 10.795
1.00 0.55 C ATOM 3502 H THR B 49 -19.450 19.828 8.907 1.00 0.00 H
ATOM 3503 HA THR B 49 -20.596 18.355 11.285 1.00 0.00 H ATOM 3504
HB THR B 49 -19.051 20.098 11.919 1.00 0.00 H ATOM 3505 HG1 THR B
49 -20.702 21.317 13.210 1.00 0.00 H ATOM 3506 1HG2 THR B 49
-19.326 22.416 10.800 1.00 0.00 H ATOM 3507 2HG2 THR B 49 -20.226
21.509 9.715 1.00 0.00 H ATOM 3508 3HG2 THR B 49 -21.061 22.206
11.101 1.00 0.00 H ATOM 3509 N ASN B 50 -22.808 19.535 11.191 1.00
0.44 N ATOM 3510 CA ASN B 50 -24.216 19.765 11.036 1.00 0.44 C ATOM
3511 C ASN B 50 -24.526 21.176 11.431 1.00 0.44 C ATOM 3512 O ASN B
50 -23.788 22.110 11.124 1.00 0.44 O ATOM 3513 CB ASN B 50 -25.082
18.854 11.923 1.00 0.44 C ATOM 3514 CG ASN B 50 -24.987 17.436
11.383 1.00 0.44 C ATOM 3515 OD1 ASN B 50 -25.306 17.184 10.223
1.00 0.44 O ATOM 3516 ND2 ASN B 50 -24.536 16.483 12.243 1.00 0.44
N ATOM 3517 H ASN B 50 -22.432 19.612 12.132 1.00 0.00 H ATOM 3518
HA ASN B 50 -24.490 19.648 9.974 1.00 0.00 H ATOM 3519 1HB ASN B 50
-26.160 19.052 11.801 1.00 0.00 H ATOM 3520 2HB ASN B 50 -24.811
18.926 12.988 1.00 0.00 H ATOM 3521 1HD2 ASN B 50 -24.229 16.692
13.173 1.00 0.00 H ATOM 3522 2HD2 ASN B 50 -24.434 15.557 11.862
1.00 0.00 H ATOM 3523 N SER B 51 -25.661 21.345 12.140 1.00 0.25 N
ATOM 3524 CA SER B 51 -26.182 22.633 12.494 1.00 0.25 C ATOM 3525 C
SER B 51 -25.171 23.418 13.267 1.00 0.25 C ATOM 3526 O SER B 51
-24.943 24.590 12.969 1.00 0.25 O ATOM 3527 CB SER B 51 -27.446
22.542 13.365 1.00 0.25 C ATOM 3528 OG SER B 51 -27.126 21.972
14.625 1.00 0.25 O ATOM 3529 H SER B 51 -26.217 20.565 12.448 1.00
0.00 H ATOM 3530 HA SER B 51 -26.415 23.201 11.580 1.00 0.00 H ATOM
3531 1HB SER B 51 -28.208 21.903 12.897 1.00 0.00 H ATOM 3532 2HB
SER B 51 -27.883 23.550 13.489 1.00 0.00 H ATOM 3533 HG SER B 51
-26.652 22.654 15.134 1.00 0.00 H ATOM 3534 N SER B 52 -24.525
22.810 14.278 1.00 0.14 N ATOM 3535 CA SER B 52 -23.591 23.593
15.036 1.00 0.14 C ATOM 3536 C SER B 52 -22.214 23.106 14.740 1.00
0.14 C ATOM 3537 O SER B 52 -21.944 21.906 14.768 1.00 0.14 O ATOM
3538 CB SER B 52 -23.794 23.486 16.557 1.00 0.14 C ATOM 3539 OG SER
B 52 -25.058 24.020 16.919 1.00 0.14 O ATOM 3540 H SER B 52 -24.570
21.822 14.458 1.00 0.00 H ATOM 3541 HA SER B 52 -23.702 24.662
14.810 1.00 0.00 H ATOM 3542 1HB SER B 52 -22.979 24.029 17.070
1.00 0.00 H ATOM 3543 2HB SER B 52 -23.770 22.444 16.905 1.00 0.00
H ATOM 3544 HG SER B 52 -24.950 24.982 16.985 1.00 0.00 H ATOM 3545
N LEU B 53 -21.296 24.040 14.422 1.00 0.09 N ATOM 3546 CA LEU B 53
-19.948 23.630 14.179 1.00 0.09 C ATOM 3547 C LEU B 53 -19.099
24.280 15.218 1.00 0.09 C ATOM 3548 O LEU B 53 -19.090 25.503
15.358 1.00 0.09 O ATOM 3549 CB LEU B 53 -19.400 24.033 12.798 1.00
0.09 C ATOM 3550 CG LEU B 53 -17.946 23.579 12.554 1.00 0.09 C ATOM
3551 CD1 LEU B 53 -17.822 22.049 12.594 1.00 0.09 C ATOM 3552 CD2
LEU B 53 -17.391 24.172 11.251 1.00 0.09 C ATOM 3553 H LEU B 53
-21.497 25.037 14.378 1.00 0.00 H ATOM 3554 HA LEU B 53 -19.873
22.545 14.292 1.00 0.00 H ATOM 3555 1HB LEU B 53 -19.407 25.138
12.754 1.00 0.00 H ATOM 3556 2HB LEU B 53 -20.106 23.754 12.014
1.00 0.00 H ATOM 3557 HG LEU B 53 -17.335 23.996 13.377 1.00 0.00 H
ATOM 3558 1HD1 LEU B 53 -16.829 21.811 13.024 1.00 0.00 H ATOM 3559
2HD1 LEU B 53 -18.521 21.535 13.257 1.00 0.00 H ATOM 3560 3HD1 LEU
B 53 -17.754 21.594 11.609 1.00 0.00 H ATOM 3561 1HD2 LEU B 53
-16.302 24.018 11.201 1.00 0.00 H ATOM 3562 2HD2 LEU B 53 -17.862
23.765 10.346 1.00 0.00 H ATOM 3563 3HD2 LEU B 53 -17.544 25.264
11.226 1.00 0.00 H ATOM 3564 N ASN B 54 -18.372 23.461 15.998 1.00
0.09 N ATOM 3565 CA ASN B 54 -17.529 24.012 17.013 1.00 0.09 C ATOM
3566 C ASN B 54 -16.131 23.631 16.666 1.00 0.09 C ATOM 3567 O ASN B
54 -15.849 22.471 16.374 1.00 0.09 O ATOM 3568 CB ASN B 54 -17.800
23.445 18.416 1.00 0.09 C ATOM 3569 CG ASN B 54 -16.982 24.254
19.411 1.00 0.09 C ATOM 3570 OD1 ASN B 54 -16.409 25.286 19.069
1.00 0.09 O ATOM 3571 ND2 ASN B 54 -16.916 23.767 20.679 1.00 0.09
N ATOM 3572 H ASN B 54 -18.263 22.475 15.832 1.00 0.00 H ATOM 3573
HA ASN B 54 -17.682 25.091 17.053 1.00 0.00 H ATOM 3574 1HB ASN B
54 -17.555 22.373 18.473 1.00 0.00 H ATOM 3575 2HB ASN B 54 -18.867
23.568 18.670 1.00 0.00 H ATOM 3576 1HD2 ASN B 54 -17.372 22.916
20.949 1.00 0.00 H ATOM 3577 2HD2 ASN B 54 -16.360 24.293 21.330
1.00 0.00 H ATOM 3578 N ILE B 55 -15.213 24.611 16.677 1.00 0.08 N
ATOM 3579 CA ILE B 55 -13.854 24.291 16.377 1.00 0.08 C ATOM 3580 C
ILE B 55 -13.041 24.735 17.542 1.00 0.08 C ATOM 3581 O ILE B 55
-13.338 25.745 18.178 1.00 0.08 O ATOM 3582 CB ILE B 55 -13.310
25.010 15.178 1.00 0.08 C ATOM 3583 CG1 ILE B 55 -13.293 26.527
15.424 1.00 0.08 C ATOM 3584 CG2 ILE B 55 -14.135 24.589 13.950
1.00 0.08 C ATOM 3585 CD1 ILE B 55 -12.481 27.296 14.384 1.00 0.08
C ATOM 3586 H ILE B 55 -15.436 25.536 17.039 1.00 0.00 H ATOM 3587
HA ILE B 55 -13.731 23.205 16.238 1.00 0.00 H ATOM 3588 HB ILE B 55
-12.270 24.659 15.038 1.00 0.00 H ATOM 3589 1HG1 ILE B 55 -12.814
26.841 16.356 1.00 0.00 H ATOM 3590 2HG1 ILE B 55 -14.341 26.851
15.420 1.00 0.00 H ATOM 3591 1HG2 ILE B 55 -13.703 24.971 13.010
1.00 0.00 H ATOM 3592 2HG2 ILE B 55 -14.181 23.491 13.855 1.00 0.00
H ATOM 3593 3HG2 ILE B 55 -15.169 24.966 14.004 1.00 0.00 H ATOM
3594 1HD1 ILE B 55 -12.528 28.384 14.547 1.00 0.00 H ATOM 3595 2HD1
ILE B 55 -11.433 26.989 14.474 1.00 0.00 H ATOM 3596 3HD1 ILE B 55
-12.805 27.104 13.349 1.00 0.00 H ATOM 3597 N VAL B 56 -11.988
23.964 17.855 1.00 0.10 N ATOM 3598 CA VAL B 56 -11.128 24.307
18.942 1.00 0.10 C ATOM 3599 C VAL B 56 -9.803 24.597 18.333 1.00
0.10 C ATOM 3600 O VAL B 56 -9.483 24.091 17.259 1.00 0.10 O ATOM
3601 CB VAL B 56 -10.938 23.177 19.914 1.00 0.10 C ATOM 3602 CG1
VAL B 56 -9.887 23.579 20.962 1.00 0.10 C ATOM 3603 CG2 VAL B 56
-12.308 22.813 20.510 1.00 0.10 C ATOM 3604 H VAL B 56 -11.643
23.243 17.244 1.00 0.00 H ATOM 3605 HA VAL B 56 -11.486 25.247
19.322 1.00 0.00 H ATOM 3606 HB VAL B 56 -10.550 22.293 19.374 1.00
0.00 H ATOM 3607 1HG1 VAL B 56 -10.078 23.069 21.922 1.00 0.00 H
ATOM 3608 2HG1 VAL B 56 -8.900 23.203 20.639 1.00 0.00 H ATOM 3609
3HG1 VAL B 56 -9.712 24.626 21.212 1.00 0.00 H ATOM 3610 1HG2 VAL B
56 -12.215 22.112 21.356 1.00 0.00 H ATOM 3611 2HG2 VAL B 56
-12.874 23.684 20.866 1.00 0.00 H ATOM 3612 3HG2 VAL B 56 -12.944
22.313 19.759 1.00 0.00 H ATOM 3613 N ASN B 57 -9.004 25.433 19.021
1.00 0.11 N ATOM 3614 CA ASN B 57 -7.708 25.802 18.547 1.00 0.11 C
ATOM 3615 C ASN B 57 -7.819 26.255 17.129 1.00 0.11 C ATOM 3616 O
ASN B 57 -7.234 25.657 16.227 1.00 0.11 O ATOM 3617 CB ASN B 57
-6.662 24.678 18.634 1.00 0.11 C ATOM 3618 CG ASN B 57 -5.291
25.321 18.470 1.00 0.11 C ATOM 3619 OD1 ASN B 57 -5.099 26.203
17.634 1.00 0.11 O ATOM 3620 ND2 ASN B 57 -4.310 24.880 19.303 1.00
0.11 N ATOM 3621 H ASN B 57 -9.361 25.917 19.839 1.00 0.00 H ATOM
3622 HA ASN B 57 -7.598 26.672 19.108 1.00 0.00 H ATOM 3623 1HB ASN
B 57 -6.807 23.906 17.861 1.00 0.00 H ATOM 3624 2HB ASN B 57 -6.743
24.176 19.613 1.00 0.00 H ATOM 3625 1HD2 ASN B 57 -4.557 24.208
20.013 1.00 0.00 H ATOM 3626 2HD2 ASN B 57 -3.547 25.508 19.482
1.00 0.00 H ATOM 3627 N ALA B 58 -8.603 27.326 16.895 1.00 0.21 N
ATOM 3628 CA ALA B 58 -8.722 27.819 15.556 1.00 0.21 C ATOM 3629 C
ALA B 58 -7.341 28.174 15.120 1.00 0.21 C ATOM 3630 O ALA B 58
-6.578 28.782 15.870 1.00 0.21 O ATOM 3631 CB ALA B 58 -9.596
29.081 15.430 1.00 0.21 C ATOM 3632 H ALA B 58 -9.197 27.733 17.613
1.00 0.00 H ATOM 3633 HA ALA B 58 -9.154 26.967 15.035 1.00 0.00 H
ATOM 3634 1HB ALA B 58 -9.729 29.336 14.369 1.00 0.00 H ATOM 3635
2HB ALA B 58 -10.589 28.921 15.874 1.00 0.00 H ATOM 3636 3HB ALA B
58 -9.118 29.932 15.936 1.00 0.00 H ATOM 3637 N LYS B 59 -6.977
27.771 13.889 1.00 0.31 N ATOM 3638 CA LYS B 59 -5.653 28.014
13.401 1.00 0.31 C ATOM 3639 C LYS B 59 -5.671 29.201 12.498 1.00
0.31 C ATOM 3640 O LYS B 59 -6.710 29.812 12.255 1.00 0.31 O ATOM
3641 CB LYS B 59 -5.066 26.841 12.597 1.00 0.31 C ATOM 3642 CG LYS
B 59 -4.819 25.592 13.445 1.00 0.31 C ATOM 3643 CD LYS B 59 -3.812
25.804 14.579 1.00 0.31 C ATOM 3644 CE LYS B 59 -3.593 24.558
15.443 1.00 0.31 C ATOM 3645 NZ LYS B 59 -2.607 24.846 16.509 1.00
0.31 N1+ ATOM 3646 H LYS B 59 -7.667 27.320 13.284 1.00 0.00 H ATOM
3647 HA LYS B 59 -4.994 28.273 14.243 1.00 0.00 H ATOM 3648 1HB LYS
B 59 -4.188 27.087 11.986 1.00 0.00 H ATOM 3649 2HB LYS B 59 -5.917
26.508 11.995 1.00 0.00 H ATOM 3650 1HG LYS B 59 -4.449 24.763
12.824 1.00 0.00 H ATOM 3651 2HG LYS B 59 -5.784 25.249 13.863 1.00
0.00 H ATOM 3652 1HD LYS B 59 -4.154 26.623 15.231 1.00 0.00 H ATOM
3653 2HD LYS B 59 -2.851 26.124 14.138 1.00 0.00 H ATOM 3654 1HE
LYS B 59 -3.202 23.717 14.846 1.00 0.00 H ATOM 3655 2HE LYS B 59
-4.527 24.225 15.925 1.00 0.00 H ATOM 3656 1HZ LYS B 59 -2.435
24.037 17.091 1.00 0.00 H ATOM 3657 2HZ LYS B 59 -1.719 25.149
16.136 1.00 0.00 H ATOM 3658 3HZ LYS B 59 -2.973 25.567 17.120 1.00
0.00 H ATOM 3659 N PHE B 60 -4.477 29.552 11.983 1.00 0.23 N ATOM
3660 CA PHE B 60 -4.318 30.638 11.063 1.00 0.23 C ATOM 3661 C PHE B
60 -5.095 30.287 9.839 1.00 0.23 C ATOM 3662 O PHE B 60 -5.704
31.140 9.197 1.00 0.23 O ATOM 3663 CB PHE B 60 -2.858 30.850 10.632
1.00 0.23 C ATOM 3664 CG PHE B 60 -2.873 31.832 9.510 1.00 0.23 C
ATOM 3665 CD1 PHE B 60 -2.961 33.184 9.748 1.00 0.23 C ATOM 3666
CD2 PHE B 60 -2.798 31.391 8.208 1.00 0.23 C ATOM 3667 CE1 PHE B 60
-2.977 34.079 8.705 1.00 0.23 C ATOM 3668 CE2 PHE B 60 -2.813
32.282 7.161 1.00 0.23 C ATOM 3669 CZ PHE B 60 -2.902 33.630 7.409
1.00 0.23 C ATOM 3670 H PHE B 60 -3.633 29.102 12.295 1.00 0.00 H
ATOM 3671 HA PHE B 60 -4.520 31.613 11.406 1.00 0.00 H ATOM 3672
1HB PHE B 60 -2.378 29.909 10.321 1.00 0.00 H ATOM 3673 2HB PHE B
60 -2.278 31.227 11.490 1.00 0.00 H ATOM 3674 HD1 PHE B 60 -3.027
33.553 10.769 1.00 0.00 H ATOM 3675 HD2 PHE B 60 -2.735 30.326
7.999 1.00 0.00 H ATOM 3676 HE1 PHE B 60 -3.056 35.145 8.908 1.00
0.00 H ATOM 3677 HE2 PHE B 60 -2.763 31.919 6.138 1.00 0.00 H ATOM
3678 HZ PHE B 60 -2.922 34.338 6.584 1.00 0.00 H ATOM 3679 N GLU B
61 -5.095 28.987 9.508 1.00 0.15 N ATOM 3680 CA GLU B 61 -5.748
28.446 8.354 1.00 0.15 C ATOM 3681 C GLU B 61 -7.218 28.714 8.459
1.00 0.15 C ATOM 3682 O GLU B 61 -7.889 28.938 7.454 1.00 0.15 O
ATOM 3683 CB GLU B 61 -5.528 26.930 8.259 1.00 0.15 C ATOM 3684 CG
GLU B 61 -5.975 26.190 9.522 1.00 0.15 C ATOM 3685 CD GLU B 61
-5.349 24.803 9.510 1.00 0.15 C ATOM 3686 OE1 GLU B 61 -5.260
24.199 8.408 1.00 0.15 O ATOM 3687 OE2 GLU B 61 -4.938 24.333
10.605 1.00 0.15 O1- ATOM 3688 H GLU B 61 -4.636 28.314 10.097 1.00
0.00 H ATOM 3689 HA GLU B 61 -5.382 28.950 7.445 1.00 0.00 H ATOM
3690 1HB GLU B 61 -4.456 26.737 8.074 1.00 0.00 H ATOM 3691 2HB GLU
B 61 -6.074 26.577 7.366 1.00 0.00 H ATOM 3692 1HG GLU B 61 -7.066
26.116 9.599 1.00 0.00 H ATOM 3693 2HG GLU B 61 -5.569 26.768
10.323 1.00 0.00 H ATOM 3694 N ASP B 62 -7.751 28.719 9.694 1.00
0.16 N ATOM 3695 CA ASP B 62 -9.160 28.869 9.932 1.00 0.16 C ATOM
3696 C ASP B 62 -9.664 30.184 9.421 1.00 0.16 C ATOM 3697 O ASP B
62 -10.828 30.280 9.041 1.00 0.16 O ATOM 3698 CB ASP B 62 -9.539
28.746 11.419 1.00 0.16 C ATOM 3699 CG ASP B 62 -9.413 27.276
11.797 1.00 0.16 C ATOM 3700 OD1 ASP B 62 -9.136 26.454 10.883 1.00
0.16 O ATOM 3701 OD2 ASP B 62 -9.605 26.952 13.000 1.00 0.16 O1-
ATOM 3702 H ASP B 62 -7.202 28.495 10.507 1.00 0.00 H ATOM 3703 HA
ASP B 62 -9.712 28.115 9.343 1.00 0.00 H ATOM 3704 1HB ASP B 62
-10.604 29.018 11.527 1.00 0.00 H ATOM 3705 2HB ASP B 62 -9.012
29.421 12.095 1.00 0.00 H ATOM 3706 N SER B 63 -8.832 31.244 9.415
1.00 0.20 N ATOM 3707 CA SER B 63 -9.308 32.524 8.962 1.00 0.20 C
ATOM 3708 C SER B 63 -9.869 32.382 7.579 1.00 0.20 C ATOM 3709 O
SER B 63 -9.321 31.677 6.734 1.00 0.20 O ATOM 3710 CB SER B 63
-8.213 33.604 8.921 1.00 0.20 C ATOM 3711 OG SER B 63 -7.222 33.255
7.966 1.00 0.20 O ATOM 3712 H SER B 63 -7.856 31.085 9.622 1.00
0.00 H ATOM 3713 HA SER B 63 -10.093 32.837 9.673 1.00 0.00 H ATOM
3714 1HB SER B 63 -7.772 33.760 9.916 1.00 0.00 H ATOM 3715 2HB SER
B 63 -8.648 34.553 8.584 1.00 0.00 H ATOM 3716 HG SER B 63 -6.730
32.485 8.307 1.00 0.00 H ATOM 3717 N GLY B 64 -11.016 33.050 7.328
1.00 0.22 N ATOM 3718 CA GLY B 64 -11.651 32.974 6.044 1.00 0.22 C
ATOM 3719 C GLY B 64 -13.081 33.365 6.233 1.00 0.22 C ATOM 3720 O
GLY B 64 -13.461 33.869 7.288 1.00 0.22 O ATOM 3721 H GLY B 64
-11.410 33.693 8.006 1.00 0.00 H ATOM 3722 1HA GLY B 64 -11.495
32.015 5.554 1.00 0.00 H ATOM 3723 2HA GLY B 64 -11.200 33.716
5.359 1.00 0.00 H ATOM 3724 N GLU B 65 -13.918 33.138 5.199 1.00
0.19 N ATOM 3725 CA GLU B 65 -15.307 33.483 5.302 1.00 0.19 C ATOM
3726 C GLU B 65 -16.074 32.222 5.515 1.00 0.19 C ATOM 3727 O GLU B
65 -15.711 31.164 5.000 1.00 0.19 O ATOM 3728 CB GLU B 65 -15.910
34.122 4.040 1.00 0.19 C ATOM 3729 CG GLU B 65 -15.403 35.529 3.730
1.00 0.19 C ATOM 3730 CD GLU B 65 -16.200 36.045 2.539 1.00 0.19 C
ATOM 3731 OE1 GLU B 65 -16.409 35.260 1.575 1.00 0.19 O ATOM 3732
OE2 GLU B 65 -16.625 37.231 2.584 1.00 0.19 O1- ATOM 3733 H GLU B
65 -13.592 32.750 4.322 1.00 0.00 H ATOM 3734 HA GLU B 65 -15.418
34.200 6.112 1.00 0.00 H ATOM 3735 1HB GLU B 65 -16.996 34.170
4.211 1.00 0.00 H ATOM 3736 2HB GLU B 65 -15.743 33.449 3.182 1.00
0.00 H ATOM 3737 1HG GLU B 65 -14.334 35.505 3.473 1.00 0.00 H ATOM
3738 2HG GLU B 65 -15.576 36.196 4.587 1.00 0.00 H ATOM 3739 N TYR
B 66 -17.164 32.306 6.304 1.00 0.22 N ATOM 3740 CA TYR B 66 -17.970
31.148 6.549 1.00 0.22 C ATOM 3741 C TYR B 66 -19.342 31.425 6.020
1.00 0.22 C ATOM 3742 O TYR B 66 -19.839 32.548 6.099 1.00 0.22 O
ATOM 3743 CB TYR B 66 -18.124 30.795 8.040 1.00 0.22 C ATOM 3744 CG
TYR B 66 -16.782 30.418 8.567 1.00 0.22 C ATOM 3745 CD1 TYR B 66
-15.918 31.384 9.033 1.00 0.22 C ATOM 3746 CD2 TYR B 66 -16.382
29.102 8.592 1.00 0.22 C ATOM 3747 CE1 TYR B 66 -14.679 31.041
9.522 1.00 0.22 C ATOM 3748 CE2 TYR B 66 -15.144 28.752 9.078 1.00
0.22 C ATOM 3749 CZ TYR B 66 -14.291 29.723 9.544 1.00 0.22 C ATOM
3750 OH TYR B 66 -13.021 29.367 10.044 1.00 0.22 O ATOM 3751 H TYR
B 66 -17.342 33.146 6.847 1.00 0.00 H ATOM 3752 HA TYR B 66 -17.532
30.275 6.047 1.00 0.00 H ATOM 3753 1HB TYR B 66 -18.806 29.929
8.084 1.00 0.00 H ATOM 3754 2HB TYR B 66 -18.599 31.552 8.651 1.00
0.00 H ATOM 3755 HD1 TYR B 66 -16.191 32.433 9.006 1.00 0.00 H ATOM
3756 HD2 TYR B 66 -17.046 28.325 8.221 1.00 0.00 H ATOM 3757 HE1
TYR B 66 -13.997 31.799 9.847 1.00 0.00 H ATOM 3758 HE2 TYR B 66
-14.837 27.708 9.090 1.00 0.00 H ATOM 3759 HH TYR B 66 -12.338
29.749 9.466 1.00 0.00 H ATOM 3760 N LYS B 67 -19.979 30.391 5.440
1.00 0.45 N ATOM 3761 CA LYS B 67 -21.299 30.533 4.900 1.00 0.45 C
ATOM 3762 C LYS B 67 -22.038 29.279 5.238 1.00 0.45 C ATOM 3763 O
LYS B 67 -21.429 28.239 5.482 1.00 0.45 O ATOM 3764 CB LYS B 67
-21.302 30.655 3.371 1.00 0.45 C ATOM 3765 CG LYS B 67 -20.591
31.913 2.871 1.00 0.45 C ATOM 3766 CD LYS B 67 -20.205 31.847 1.394
1.00 0.45 C ATOM 3767 CE LYS B 67 -18.982 30.964 1.129 1.00 0.45 C
ATOM 3768 NZ LYS B 67 -17.786 31.563 1.761 1.00 0.45 N1+ ATOM 3769
H LYS B 67 -19.578 29.462 5.412 1.00 0.00 H ATOM 3770 HA LYS B 67
-21.802 31.400 5.361 1.00 0.00 H ATOM 3771 1HB LYS B 67 -22.349
30.675 3.016 1.00 0.00 H ATOM 3772 2HB LYS B 67 -20.856 29.741
2.952 1.00 0.00 H ATOM 3773 1HG LYS B 67 -19.696 32.152 3.468 1.00
0.00 H ATOM 3774 2HG LYS B 67 -21.325 32.705 3.088 1.00 0.00 H ATOM
3775 1HD LYS B 67 -19.999 32.836 0.954 1.00 0.00 H ATOM 3776 2HD
LYS B 67 -21.053 31.439 0.812 1.00 0.00 H ATOM 3777 1HE LYS B 67
-18.775 30.885 0.049 1.00 0.00 H ATOM 3778 2HE LYS B 67 -19.097
29.947 1.529 1.00 0.00 H ATOM 3779 1HZ LYS B 67 -16.926 31.112
1.480 1.00 0.00 H ATOM 3780 2HZ LYS B 67 -17.675 32.541 1.507 1.00
0.00 H ATOM 3781 3HZ LYS B 67 -17.826 31.529 2.772 1.00 0.00 H ATOM
3782 N CYS B 68 -23.383 29.354 5.281 1.00 0.52 N ATOM 3783 CA CYS B
68 -24.163 28.196 5.606 1.00 0.52 C ATOM 3784 C CYS B 68 -25.428
28.222 4.811 1.00 0.52 C ATOM 3785 O CYS B 68 -25.970 29.288 4.524
1.00 0.52 O ATOM 3786 CB CYS B 68 -24.621 28.179 7.C65 1.00 0.52
C
ATOM 3787 SG CYS B 68 -25.956 26.981 7.311 1.00 0.52 S ATOM 3788 H
CYS B 68 -23.896 30.171 5.002 1.00 0.00 H ATOM 3789 HA CYS B 68
-23.591 27.287 5.374 1.00 0.00 H ATOM 3790 1HB CYS B 68 -24.992
29.178 7.349 1.00 0.00 H ATOM 3791 2HB CYS B 68 -23.803 27.921
7.723 1.00 0.00 H ATOM 3792 N GLN B 69 -25.931 27.034 4.420 1.00
0.27 N ATOM 3793 CA GLN B 69 -27.206 27.001 3.771 1.00 0.27 C ATOM
3794 C GLN B 69 -27.926 25.780 4.234 1.00 0.27 C ATOM 3795 O GLN B
69 -27.323 24.828 4.727 1.00 0.27 O ATOM 3796 CB GLN B 69 -27.150
26.927 2.237 1.00 0.27 C ATOM 3797 CG GLN B 69 -26.530 25.639 1.700
1.00 0.27 C ATOM 3798 CD GLN B 69 -26.687 25.656 0.186 1.00 0.27 C
ATOM 3799 OE1 GLN B 69 -27.435 26.466 -0.360 1.00 0.27 O ATOM 3800
NE2 GLN B 69 -25.967 24.736 -0.511 1.00 0.27 N ATOM 3801 H GLN B 69
-25.524 26.151 4.696 1.00 0.00 H ATOM 3802 HA GLN B 69 -27.798
27.874 4.081 1.00 0.00 H ATOM 3803 1HB GLN B 69 -26.598 27.802
1.859 1.00 0.00 H ATOM 3804 2HB GLN B 69 -28.189 27.025 1.876 1.00
0.00 H ATOM 3805 1HG GLN B 69 -27.185 24.835 2.029 1.00 0.00 H ATOM
3806 2HG GLN B 69 -25.497 25.492 2.036 1.00 0.00 H ATOM 3807 1HE2
GLN B 69 -25.235 24.219 -0.068 1.00 0.00 H ATOM 3808 2HE2 GLN B 69
-25.927 24.943 -1.496 1.00 0.00 H ATOM 3809 N HIS B 70 -29.263
25.803 4.102 1.00 0.11 N ATOM 3810 CA HIS B 70 -30.076 24.678 4.443
1.00 0.11 C ATOM 3811 C HIS B 70 -30.899 24.396 3.237 1.00 0.11 C
ATOM 3812 O HIS B 70 -30.877 25.150 2.267 1.00 0.11 O ATOM 3813 CB
HIS B 70 -31.043 24.920 5.612 1.00 0.11 C ATOM 3814 CG HIS B 70
-30.339 24.997 6.930 1.00 0.11 C ATOM 3815 ND1 HIS B 70 -29.937
23.891 7.646 1.00 0.11 N ATOM 3816 CD2 HIS B 70 -29.953 26.075
7.664 1.00 0.11 C ATOM 3817 CE1 HIS B 70 -29.331 24.351 8.768 1.00
0.11 C ATOM 3818 NE2 HIS B 70 -29.316 25.671 8.824 1.00 0.11 N ATOM
3819 H HIS B 70 -29.699 26.490 3.501 1.00 0.00 H ATOM 3820 HA HIS B
70 -29.447 23.799 4.660 1.00 0.00 H ATOM 3821 1HB HIS B 70 -31.766
24.089 5.657 1.00 0.00 H ATOM 3822 2HB HIS B 70 -31.637 25.829
5.471 1.00 0.00 H ATOM 3823 HD2 HIS B 70 -30.099 27.123 7.447 1.00
0.00 H ATOM 3824 HE1 HIS B 70 -29.020 23.707 9.580 1.00 0.00 H ATOM
3825 HE2 HIS B 70 -29.018 26.241 9.593 1.00 0.00 H ATOM 3826 N GLN
B 71 -31.625 23.266 3.251 1.00 0.12 N ATOM 3827 CA GLN B 71 -32.441
22.954 2.121 1.00 0.12 C ATOM 3828 C GLN B 71 -33.468 24.032 2.009
1.00 0.12 C ATOM 3829 O GLN B 71 -33.753 24.525 0.920 1.00 0.12 O
ATOM 3830 CB GLN B 71 -33.197 21.623 2.276 1.00 0.12 C ATOM 3831 CG
GLN B 71 -32.304 20.379 2.279 1.00 0.12 C ATOM 3832 CD GLN B 71
-31.895 20.083 0.843 1.00 0.12 C ATOM 3833 OE1 GLN B 71 -32.123
20.883 -0.063 1.00 0.12 O ATOM 3834 NE2 GLN B 71 -31.272 18.896
0.623 1.00 0.12 N ATOM 3835 H GLN B 71 -31.669 22.648 4.050 1.00
0.00 H ATOM 3836 HA GLN B 71 -31.834 22.977 1.204 1.00 0.00 H ATOM
3837 1HB GLN B 71 -33.962 21.545 1.481 1.00 0.00 H ATOM 3838 2HB
GLN B 71 -33.758 21.654 3.225 1.00 0.00 H ATOM 3839 1HG GLN B 71
-32.874 19.519 2.668 1.00 0.00 H ATOM 3840 2HG GLN B 71 -31.411
20.534 2.901 1.00 0.00 H ATOM 3841 1HE2 GLN B 71 -31.125 18.252
1.392 1.00 0.00 H ATOM 3842 2HE2 GLN B 71 -31.056 18.634 -0.322
1.00 0.00 H ATOM 3843 N GLN B 72 -34.046 24.426 3.157 1.00 0.21 N
ATOM 3844 CA GLN B 72 -35.117 25.377 3.188 1.00 0.21 C ATOM 3845 C
GLN B 72 -34.660 26.737 2.761 1.00 0.21 C ATOM 3846 O GLN B 72
-35.308 27.383 1.940 1.00 0.21 O ATOM 3847 CB GLN B 72 -35.698
25.546 4.602 1.00 0.21 C ATOM 3848 CG GLN B 72 -36.104 24.222 5.252
1.00 0.21 C ATOM 3849 CD GLN B 72 -37.057 23.494 4.316 1.00 0.21 C
ATOM 3850 OE1 GLN B 72 -37.630 24.082 3.400 1.00 0.21 O ATOM 3851
NE2 GLN B 72 -37.224 22.165 4.547 1.00 0.21 N ATOM 3852 H GLN B 72
-33.776 24.011 4.029 1.00 0.00 H ATOM 3853 HA GLN B 72 -35.857
25.085 2.433 1.00 0.00 H ATOM 3854 1HB GLN B 72 -36.568 26.218
4.507 1.00 0.00 H ATOM 3855 2HB GLN B 72 -34.952 26.056 5.225 1.00
0.00 H ATOM 3856 1HG GLN B 72 -36.614 24.285 6.211 1.00 0.00 H ATOM
3857 2HG GLN B 72 -35.212 23.596 5.418 1.00 0.00 H ATOM 3858 1HE2
GLN B 72 -36.791 21.725 5.340 1.00 0.00 H ATOM 3859 2HE2 GLN B 72
-37.890 21.689 3.966 1.00 0.00 H ATOM 3860 N VAL B 73 -33.516
27.206 3.298 1.00 0.31 N ATOM 3861 CA VAL B 73 -33.130 28.569 3.072
1.00 0.31 C ATOM 3862 C VAL B 73 -32.145 28.702 1.959 1.00 0.31 C
ATOM 3863 O VAL B 73 -31.658 27.727 1.388 1.00 0.31 O ATOM 3864 CB
VAL B 73 -32.521 29.216 4.283 1.00 0.31 C ATOM 3865 CG1 VAL B 73
-33.583 29.264 5.395 1.00 0.31 C ATOM 3866 CG2 VAL B 73 -31.247
28.442 4.666 1.00 0.31 C ATOM 3867 H VAL B 73 -32.902 26.625 3.835
1.00 0.00 H ATOM 3868 HA VAL B 73 -34.032 29.136 2.786 1.00 0.00 H
ATOM 3869 HB VAL B 73 -32.166 30.225 4.101 1.00 0.00 H ATOM 3870
1HG1 VAL B 73 -33.219 29.820 6.275 1.00 0.00 H ATOM 3871 2HG1 VAL B
73 -34.505 29.762 5.053 1.00 0.00 H ATOM 3872 3HG1 VAL B 73 -33.855
28.254 5.740 1.00 0.00 H ATOM 3873 1HG2 VAL B 73 -31.260 28.169
5.729 1.00 0.00 H ATOM 3874 2HG2 VAL B 73 -31.174 27.490 4.129 1.00
0.00 H ATOM 3875 3HG2 VAL B 73 -30.331 28.965 4.407 1.00 0.00 H
ATOM 3876 N ASN B 74 -31.857 29.979 1.634 1.00 0.41 N ATOM 3877 CA
ASN B 74 -30.932 30.413 0.630 1.00 0.41 C ATOM 3878 C ASN B 74
-29.580 30.362 1.270 1.00 0.41 C ATOM 3879 O ASN B 74 -29.409
29.751 2.322 1.00 0.41 O ATOM 3880 CB ASN B 74 -31.202 31.869 0.200
1.00 0.41 C ATOM 3881 CG ASN B 74 -30.458 32.179 -1.090 1.00 0.41 C
ATOM 3882 OD1 ASN B 74 -29.812 31.313 -1.676 1.00 0.41 O ATOM 3883
ND2 ASN B 74 -30.542 33.459 -1.542 1.00 0.41 N ATOM 3884 H ASN B 74
-32.331 30.717 2.145 1.00 0.00 H ATOM 3885 HA ASN B 74 -30.976
29.713 -0.222 1.00 0.00 H ATOM 3886 1HB ASN B 74 -30.921 32.561
1.004 1.00 0.00 H ATOM 3887 2HB ASN B 74 -32.278 32.002 -0.003 1.00
0.00 H ATOM 3888 1HD2 ASN B 74 -30.976 34.179 -0.997 1.00 0.00 H
ATOM 3889 2HD2 ASN B 74 -29.971 33.687 -2.339 1.00 0.00 H ATOM 3890
N GLU B 75 -28.567 30.970 0.622 1.00 0.48 N ATOM 3891 CA GLU B 75
-27.249 31.003 1.180 1.00 0.48 C ATOM 3892 C GLU B 75 -27.241
32.069 2.228 1.00 0.48 C ATOM 3893 O GLU B 75 -27.925 33.085 2.100
1.00 0.48 O ATOM 3894 CB GLU B 75 -26.170 31.366 0.145 1.00 0.48 C
ATOM 3895 CG GLU B 75 -26.047 30.340 -0.982 1.00 0.48 C ATOM 3896
CD GLU B 75 -25.367 29.103 -0.418 1.00 0.48 C ATOM 3897 OE1 GLU B
75 -24.699 29.229 0.643 1.00 0.48 O ATOM 3898 OE2 GLU B 75 -25.503
28.015 -1.039 1.00 0.48 O1- ATOM 3899 H GLU B 75 -28.657 31.252
-0.347 1.00 0.00 H ATOM 3900 HA GLU B 75 -27.017 30.019 1.621 1.00
0.00 H ATOM 3901 1HB GLU B 75 -25.207 31.519 0.665 1.00 0.00 H ATOM
3902 2HB GLU B 75 -26.423 32.357 -0.272 1.00 0.00 H ATOM 3903 1HG
GLU B 75 -25.416 30.732 -1.797 1.00 0.00 H ATOM 3904 2HG GLU B 75
-27.009 30.079 -1.450 1.00 0.00 H ATOM 3905 N SER B 76 -26.469
31.848 3.309 1.00 0.42 N ATOM 3906 CA SER B 76 -26.382 32.800 4.377
1.00 0.42 C ATOM 3907 C SER B 76 -25.336 33.802 4.009 1.00 0.42 C
ATOM 3908 O SER B 76 -24.507 33.553 3.136 1.00 0.42 O ATOM 3909 CB
SER B 76 -25.956 32.162 5.710 1.00 0.42 C ATOM 3910 OG SER B 76
-25.873 33.153 6.720 1.00 0.42 O ATOM 3911 H SER B 76 -26.027
30.945 3.444 1.00 0.00 H ATOM 3912 HA SER B 76 -27.347 33.318 4.497
1.00 0.00 H ATOM 3913 1HB SER B 76 -24.918 31.818 5.529 1.00 0.00 H
ATOM 3914 2HB SER B 76 -26.368 31.266 6.179 1.00 0.00 H ATOM 3915
HG SER B 76 -25.076 33.682 6.522 1.00 0.00 H ATOM 3916 N GLU B 77
-25.365 34.985 4.660 1.00 0.31 N ATOM 3917 CA GLU B 77 -24.357
35.963 4.380 1.00 0.31 C ATOM 3918 C GLU B 77 -23.106 35.440 4.998
1.00 0.31 C ATOM 3919 O GLU B 77 -23.138 34.721 5.994 1.00 0.31 O
ATOM 3920 CB GLU B 77 -24.596 37.339 5.023 1.00 0.31 C ATOM 3921 CG
GLU B 77 -25.878 38.032 4.571 1.00 0.31 C ATOM 3922 CD GLU B 77
-26.987 37.538 5.483 1.00 0.31 C ATOM 3923 OE1 GLU B 77 -26.707
37.359 6.699 1.00 0.31 O ATOM 3924 OE2 GLU B 77 -28.123 37.331
4.981 1.00 0.31 O1- ATOM 3925 H GLU B 77 -26.107 35.274 5.290 1.00
0.00 H ATOM 3926 HA GLU B 77 -24.351 36.141 3.293 1.00 0.00 H ATOM
3927 1HB GLU B 77 -23.730 37.950 4.704 1.00 0.00 H ATOM 3928 2HB
GLU B 77 -24.496 37.287 6.121 1.00 0.00 H ATOM 3929 1HG GLU B 77
-26.103 37.866 3.506 1.00 0.00 H ATOM 3930 2HG GLU B 77 -25.778
39.121 4.715 1.00 0.00 H ATOM 3931 N PRO B 78 -22.004 35.772 4.398
1.00 0.29 N ATOM 3932 CA PRO B 78 -20.764 35.287 4.932 1.00 0.29 C
ATOM 3933 C PRO B 78 -20.323 36.023 6.154 1.00 0.29 C ATOM 3934 O
PRO B 78 -20.684 37.187 6.323 1.00 0.29 O ATOM 3935 CB PRO B 78
-19.756 35.357 3.788 1.00 0.29 C ATOM 3936 CG PRO B 78 -20.627
35.223 2.527 1.00 0.29 C ATOM 3937 CD PRO B 78 -21.979 35.824 2.944
1.00 0.29 C ATOM 3938 HA PRO B 78 -20.930 34.229 5.154 1.00 0.00 H
ATOM 3939 1HB PRO B 78 -18.975 34.595 3.881 1.00 0.00 H ATOM 3940
2HB PRO B 78 -19.253 36.340 3.777 1.00 0.00 H ATOM 3941 1HG PRO B
78 -20.743 34.219 2.155 1.00 0.00 H ATOM 3942 2HG PRO B 78 -20.192
35.781 1.679 1.00 0.00 H ATOM 3943 1HD PRO B 78 -22.062 36.874
2.622 1.00 0.00 H ATOM 3944 2HD PRO B 78 -22.791 35.253 2.482 1.00
0.00 H ATOM 3945 N VAL B 79 -19.557 35.337 7.022 1.00 0.31 N ATOM
3946 CA VAL B 79 -18.978 35.931 8.187 1.00 0.31 C ATOM 3947 C VAL B
79 -17.507 35.760 8.006 1.00 0.31 C ATOM 3948 O VAL B 79 -17.055
34.693 7.593 1.00 0.31 O ATOM 3949 CB VAL B 79 -19.362 35.248 9.465
1.00 0.31 C ATOM 3950 CG1 VAL B 79 -18.925 33.776 9.386 1.00 0.31 C
ATOM 3951 CG2 VAL B 79 -18.732 36.018 10.638 1.00 0.31 C ATOM 3952
H VAL B 79 -19.361 34.360 6.860 1.00 0.00 H ATOM 3953 HA VAL B 79
-19.257 36.997 8.216 1.00 0.00 H ATOM 3954 HB VAL B 79 -20.462
35.289 9.567 1.00 0.00 H ATOM 3955 1HG1 VAL B 79 -19.391 33.205
10.210 1.00 0.00 H ATOM 3956 2HG1 VAL B 79 -19.283 33.319 8.460
1.00 0.00 H ATOM 3957 3HG1 VAL B 79 -17.846 33.643 9.523 1.00 0.00
H ATOM 3958 1HG2 VAL B 79 -19.088 35.629 11.607 1.00 0.00 H ATOM
3959 2HG2 VAL B 79 -17.634 35.926 10.652 1.00 0.00 H ATOM 3960 3HG2
VAL B 79 -18.990 37.090 10.606 1.00 0.00 H ATOM 3961 N TYR B 80
-16.709 36.805 8.294 1.00 0.19 N ATOM 3962 CA TYR B 80 -15.305
36.638 8.067 1.00 0.19 C ATOM 3963 C TYR B 80 -14.649 36.465 9.394
1.00 0.19 C ATOM 3964 O TYR B 80 -14.925 37.197 10.343 1.00 0.19 O
ATOM 3965 CB TYR B 80 -14.628 37.826 7.359 1.00 0.19 C ATOM 3966 CG
TYR B 80 -13.244 37.390 7.018 1.00 0.19 C ATOM 3967 CD1 TYR B 80
-12.214 37.522 7.921 1.00 0.19 C ATOM 3968 CD2 TYR B 80 -12.983
36.837 5.785 1.00 0.19 C ATOM 3969 CE1 TYR B 80 -10.942 37.112
7.597 1.00 0.19 C ATOM 3970 CE2 TYR B 80 -11.714 36.425 5.454 1.00
0.19 C ATOM 3971 CZ TYR B 80 -10.692 36.565 6.360 1.00 0.19 C ATOM
3972 OH TYR B 80 -9.387 36.143 6.025 1.00 0.19 O ATOM 3973 H TYR B
80 -17.008 37.682 8.682 1.00 0.00 H ATOM 3974 HA TYR B 80 -15.133
35.776 7.415 1.00 0.00 H ATOM 3975 1HB TYR B 80 -14.633 38.725
7.994 1.00 0.00 H ATOM 3976 2HB TYR B 80 -15.197 38.081 6.450 1.00
0.00 H ATOM 3977 HD1 TYR B 80 -12.423 37.965 8.890 1.00 0.00 H ATOM
3978 HD2 TYR B 80 -13.756 36.817 5.036 1.00 0.00 H ATOM 3979 HE1
TYR B 80 -10.137 37.169 8.309 1.00 0.00 H ATOM 3980 HE2 TYR B 80
-11.519 36.016 4.465 1.00 0.00 H ATOM 3981 HH TYR B 80 -8.978
35.822 6.837 1.00 0.00 H ATOM 3982 N LEU B 81 -13.760 35.460 9.490
1.00 0.08 N ATOM 3983 CA LEU B 81 -13.094 35.195 10.729 1.00 0.08 C
ATOM 3984 C LEU B 81 -11.635 35.443 10.529 1.00 0.08 C ATOM 3985 O
LEU B 81 -11.076 35.109 9.485 1.00 0.08 O ATOM 3986 CB LEU B 81
-13.250 33.736 11.191 1.00 0.08 C ATOM 3987 CG LEU B 81 -12.542
33.429 12.522 1.00 0.08 C ATOM 3988 CD1 LEU B 81 -13.157 34.234
13.678 1.00 0.08 C ATOM 3989 CD2 LEU B 81 -12.505 31.918 12.800
1.00 0.08 C ATOM 3990 H LEU B 81 -13.530 34.870 8.697 1.00 0.00 H
ATOM 3991 HA LEU B 81 -13.489 35.875 11.494 1.00 0.00 H ATOM 3992
1HB LEU B 81 -12.768 33.124 10.414 1.00 0.00 H ATOM 3993 2HB LEU B
81 -14.319 33.473 11.257 1.00 0.00 H ATOM 3994 HG LEU B 81 -11.483
33.725 12.421 1.00 0.00 H ATOM 3995 1HD1 LEU B 81 -12.405 34.520
14.427 1.00 0.00 H ATOM 3996 2HD1 LEU B 81 -13.691 35.135 13.359
1.00 0.00 H ATOM 3997 3HD1 LEU B 81 -13.915 33.631 14.207 1.00 0.00
H ATOM 3998 1HD2 LEU B 81 -11.952 31.695 13.726 1.00 0.00 H ATOM
3999 2HD2 LEU B 81 -13.519 31.498 12.903 1.00 0.00 H ATOM 4000 3HD2
LEU B 81 -12.001 31.377 11.982 1.00 0.00 H ATOM 4001 N GLU B 82
-10.987 36.068 11.529 1.00 0.09 N ATOM 4002 CA GLU B 82 -9.582
36.329 11.444 1.00 0.09 C ATOM 4003 C GLU B 82 -8.969 35.717 12.660
1.00 0.09 C ATOM 4004 O GLU B 82 -9.443 35.926 13.776 1.00 0.09 O
ATOM 4005 CB GLU B 82 -9.250 37.831 11.486 1.00 0.09 C ATOM 4006 CG
GLU B 82 -9.774 38.615 10.282 1.00 0.09 C ATOM 4007 CD GLU B 82
-9.587 40.099 10.568 1.00 0.09 C ATOM 4008 OE1 GLU B 82 -8.557
40.458 11.201 1.00 0.09 O ATOM 4009 OE2 GLU B 82 -10.477 40.894
10.166 1.00 0.09 O1- ATOM 4010 H GLU B 82 -11.437 36.370 12.385
1.00 0.00 H ATOM 4011 HA GLU B 82 -9.165 35.902 10.521 1.00 0.00 H
ATOM 4012 1HB GLU B 82 -8.149 37.899 11.523 1.00 0.00 H ATOM 4013
2HB GLU B 82 -9.643 38.266 12.420 1.00 0.00 H ATOM 4014 1HG GLU B
82 -10.829 38.415 10.073 1.00 0.00 H ATOM 4015 2HG GLU B 82 -9.148
38.392 9.408 1.00 0.00 H ATOM 4016 N VAL B 83 -7.896 34.930 12.476
1.00 0.09 N ATOM 4017 CA VAL B 83 -7.263 34.328 13.611 1.00 0.09 C
ATOM 4018 C VAL B 83 -5.907 34.938 13.711 1.00 0.09 C ATOM 4019 O
VAL B 83 -5.239 35.146 12.700 1.00 0.09 O ATOM 4020 CB VAL B 83
-7.069 32.850 13.470 1.00 0.09 C ATOM 4021 CG1 VAL B 83 -8.451
32.182 13.377 1.00 0.09 C ATOM 4022 CG2 VAL B 83 -6.170 32.598
12.250 1.00 0.09 C ATOM 4023 H VAL B 83 -7.390 34.867 11.611 1.00
0.00 H ATOM 4024 HA VAL B 83 -7.846 34.520 14.521 1.00 0.00 H ATOM
4025 HB VAL B 83 -6.558 32.481 14.379 1.00 0.00 H ATOM 4026 1HG1
VAL B 83 -8.397 31.094 13.515 1.00 0.00 H ATOM 4027 2HG1 VAL B 83
-9.129 32.558 14.160 1.00 0.00 H ATOM 4028 3HG1 VAL B 83 -8.933
32.369 12.403 1.00 0.00 H ATOM 4029 1HG2 VAL B 83 -6.508 31.805
11.601 1.00 0.00 H ATOM 4030 2HG2 VAL B 83 -6.129 33.419 11.520
1.00 0.00 H ATOM 4031 3HG2 VAL B 83 -5.180 32.524 12.716 1.00 0.00
H ATOM 4032 N PHE B 84 -5.469 35.260 14.943 1.00 0.23 N ATOM 4033
CA PHE B 84 -4.182 35.872 15.076 1.00 0.23 C ATOM 4034 C PHE B 84
-3.459 35.119 16.138 1.00 0.23 C ATOM 4035 O PHE B 84 -4.077 34.442
16.959 1.00 0.23 O ATOM 4036 C3 PHE B 84 -4.229 37.314 15.606 1.00
0.23 C ATOM 4037 CG PHE B 84 -5.215 38.093 14.810 1.00 0.23 C ATOM
4038 CD1 PHE B 84 -4.889 38.632 13.590 1.00 0.23 C ATOM 4039 CD2
PHE B 84 -6.487 38.271 15.293 1.00 0.23 C ATOM 4040 CE1 PHE B 84
-5.814 39.344 12.865 1.00 0.23 C ATOM 4041 CE2 PHE B 84 -7.414
38.983 14.572 1.00 0.23 C ATOM 4042 CZ PHE B 84 -7.081 39.525
13.357 1.00 0.23 C ATOM 4043 H PHE B 84 -6.045 35.205 15.777 1.00
0.00 H ATOM 4044 HA PHE B 84 -3.619 35.831 14.132 1.00 0.00 H ATOM
4045 1HB PHE B 84 -3.221 37.757 15.548 1.00 0.00 H ATOM 4046 2HB
PHE B 84 -4.503 37.318 16.673 1.00 0.00 H ATOM 4047 HD1 PHE B 84
-3.881 38.507 13.203 1.00 0.00 H ATOM 4048 HD2 PHE B 84 -6.776
37.774 16.212 1.00 0.00 H ATOM 4049 HE1 PHE B 84 -5.532 39.800
11.919 1.00 0.00 H ATOM 4050 HE2 PHE B 84 -8.434 38.672 14.642 1.00
0.00 H ATOM 4051 HZ PHE B 84 -7.738 40.278 13.011 1.00 0.00 H ATOM
4052 N SER B 85 -2.115 35.187 16.131 1.00 0.34 N ATOM 4053 CA SER B
85 -1.395 34.574 17.204 1.00 0.34 C ATOM 4054 C SER B 85 -0.673
35.676 17.915 1.00 0.34 C ATOM 4055 O SER B 85 0.388 36.126 17.488
1.00 0.34 O ATOM 4056 CB SER B 85 -0.370 33.520 16.748 1.00 0.34 C
ATOM 4057 OG SER B 85 0.610 34.106 15.906 1.00 0.34 O ATOM 4058 H
SER B 85 -1.592 35.821 15.547 1.00 0.00 H ATOM 4059 HA SER B 85
-2.077 34.071 17.905 1.00 0.00 H ATOM 4060 1HB SER B 85 -0.858
32.718 16.180 1.00 0.00 H ATOM 4061 2HB SER B 85 0.105 33.091
17.647 1.00 0.00 H ATOM 4062 HG SER B 85 0.896 34.924 16.364 1.00
0.00 H ATOM 4063 N ASP B 86 -1.255 36.148 19.032 1.00 0.23 N ATOM
4064 CA ASP B 86 -0.646 37.204 19.785 1.00 0.23 C ATOM 4065 C ASP B
86 -0.958 36.941 21.219 1.00 0.23 C ATOM 4066 O ASP B 86 -1.850
36.156 21.535 1.00 0.23 O ATOM 4067 CB ASP B 86 -1.209 38.597
19.458 1.00 0.23 C ATOM 4068 CG ASP B 86 -0.750 38.977 18.058 1.00
0.23 C ATOM 4069 OD1 ASP B 86 0.436 38.705 17.730 1.00 0.23 O ATOM
4070 OD2 ASP B 86 -1.581 39.538 17.294 1.00 0.23 O1- ATOM 4071 H
ASP B 86 -2.098 35.791 19.438 1.00 0.00 H ATOM 4072 HA ASP B 86
0.450 37.190 19.655 1.00 0.00 H ATOM 4073 1HB ASP B 86 -0.728
39.310 20.149 1.00 0.00 H ATOM 4074 2HB ASP B 86 -2.265 38.846
19.445 1.00 0.00 H ATOM 4075 N TRP B 87 -0.199 37.567 22.136 1.00
0.14 N
ATOM 4076 CA TRP B 87 -0.482 37.366 23.524 1.00 0.14 C ATOM 4077 C
TRP B 87 -1.782 37.995 23.895 1.00 0.14 C ATOM 4078 O TRP B 87
-2.587 37.390 24.598 1.00 0.14 O ATOM 4079 CB TRP B 87 0.603 37.882
24.479 1.00 0.14 C ATOM 4080 CG TRP B 87 1.760 36.923 24.577 1.00
0.14 C ATOM 4081 CD1 TRP B 87 3.025 36.993 24.074 1.00 0.14 C ATOM
4082 CD2 TRP B 87 1.660 35.660 25.254 1.00 0.14 C ATOM 4083 NE1 TRP
B 87 3.722 35.852 24.401 1.00 0.14 N ATOM 4084 CE2 TRP B 87 2.892
35.022 25.126 1.00 0.14 C ATOM 4085 CE3 TRP B 87 0.621 35.080
25.924 1.00 0.14 C ATOM 4086 CZ2 TRP B 87 3.106 33.786 25.670 1.00
0.14 C ATOM 4087 CZ3 TRP B 87 0.839 33.837 26.474 1.00 0.14 C ATOM
4088 CH2 TRP B 87 2.058 33.201 26.350 1.00 0.14 C ATOM 4089 H TRP B
87 0.548 38.189 21.872 1.00 0.00 H ATOM 4090 HA TRP B 87 -0.614
36.285 23.692 1.00 0.00 H ATOM 4091 1HB TRP B 87 0.152 37.992
25.482 1.00 0.00 H ATOM 4092 2HB TRP B 87 0.938 38.892 24.197 1.00
0.00 H ATOM 4093 HD1 TRP B 87 3.478 37.795 23.504 1.00 0.00 H ATOM
4094 HE1 TRP B 87 4.680 35.678 24.202 1.00 0.00 H ATOM 4095 HE3 TRP
B 87 -0.335 35.580 26.045 1.00 0.00 H ATOM 4096 HZ2 TRP B 87 4.070
33.292 25.578 1.00 0.00 H ATOM 4097 HZ3 TRP B 87 0.071 33.373
27.066 1.00 0.00 H ATOM 4098 HH2 TRP B 87 2.209 32.237 26.826 1.00
0.00 H ATOM 4099 N LEU B 88 -2.035 39.229 23.423 1.00 0.12 N ATOM
4100 CA LEU B 88 -3.244 39.894 23.818 1.00 0.12 C ATOM 4101 C LEU B
88 -3.845 40.527 22.607 1.00 0.12 C ATOM 4102 O LEU B 88 -3.126
40.978 21.717 1.00 0.12 O ATOM 4103 CB LEU B 88 -2.988 41.028
24.827 1.00 0.12 C ATOM 4104 CG LEU B 88 -4.252 41.777 25.294 1.00
0.12 C ATOM 4105 CD1 LEU B 88 -5.169 40.882 26.135 1.00 0.12 C ATOM
4106 CD2 LEU B 88 -3.893 43.089 26.012 1.00 0.12 C ATOM 4107 H LEU
B 88 -1.477 39.686 22.720 1.00 0.00 H ATOM 4108 HA LEU B 88 -3.946
39.167 24.244 1.00 0.00 H ATOM 4109 1HB LEU B 88 -2.285 41.747
24.367 1.00 0.00 H ATOM 4110 2HB LEU B 88 -2.468 40.616 25.711 1.00
0.00 H ATOM 4111 HG LEU B 88 -4.825 42.096 24.412 1.00 0.00 H ATOM
4112 1HD1 LEU B 88 -6.215 40.971 25.827 1.00 0.00 H ATOM 4113 2HD1
LEU B 88 -4.833 39.841 26.171 1.00 0.00 H ATOM 4114 3HD1 LEU B 88
-5.149 41.201 27.192 1.00 0.00 H ATOM 4115 1HD2 LEU B 88 -4.793
43.673 26.263 1.00 0.00 H ATOM 4116 2HD2 LEU B 88 -3.348 42.897
26.951 1.00 0.00 H ATOM 4117 3HD2 LEU B 88 -3.245 43.720 25.387
1.00 0.00 H ATOM 4118 N LEU B 89 -5.192 40.561 22.535 1.00 0.11 N
ATOM 4119 CA LEU B 89 -5.817 41.207 21.418 1.00 0.11 C ATOM 4120 C
LEU B 89 -7.020 41.926 21.934 1.00 0.11 C ATOM 4121 O LEU B 89
-7.608 41.536 22.942 1.00 0.11 O ATOM 4122 CB LEU B 89 -6.316
40.242 20.325 1.00 0.11 C ATOM 4123 CG LEU B 89 -6.996 40.936
19.129 1.00 0.11 C ATOM 4124 CD1 LEU B 89 -6.001 41.822 18.356 1.00
0.11 C ATOM 4125 CD2 LEU B 89 -7.712 39.917 18.228 1.00 0.11 C ATOM
4126 H LEU B 89 -5.791 40.201 23.266 1.00 0.00 H ATOM 4127 HA LEU B
89 -5.075 41.763 20.868 1.00 0.00 H ATOM 4128 1HB LEU B 89 -7.014
39.506 20.758 1.00 0.00 H ATOM 4129 2HB LEU B 89 -5.451 39.693
19.917 1.00 0.00 H ATOM 4130 HG LEU B 89 -7.828 41.548 19.479 1.00
0.00 H ATOM 4131 1HD1 LEU B 89 -6.459 42.253 17.451 1.00 0.00 H
ATOM 4132 2HD1 LEU B 89 -5.641 42.666 18.958 1.00 0.00 H ATOM 4133
3HD1 LEU B 89 -5.126 41.235 18.030 1.00 0.00 H ATOM 4134 1HD2 LEU B
89 -8.142 40.512 17.418 1.00 0.00 H ATOM 4135 2HD2 LEU B 89 -7.007
39.183 17.817 1.00 0.00 H ATOM 4136 3HD2 LEU B 89 -8.511 39.382
18.761 1.00 0.00 H ATOM 4137 N LEU B 90 -7.400 43.026 21.259 1.00
0.11 N ATOM 4138 CA LEU B 90 -8.597 43.700 21.649 1.00 0.11 C ATOM
4139 C LEU B 90 -9.606 43.186 20.677 1.00 0.11 C ATOM 4140 O LEU B
90 -9.404 43.266 19.467 1.00 0.11 O ATOM 4141 CB LEU B 90 -8.527
45.232 21.510 1.00 0.11 C ATOM 4142 CG LEU B 90 -9.818 45.948
21.950 1.00 0.11 C ATOM 4143 CD1 LEU B 90 -10.083 45.729 23.448
1.00 0.11 C ATOM 4144 CD2 LEU B 90 -9.793 47.437 21.568 1.00 0.11 C
ATOM 4145 H LEU B 90 -6.910 43.370 20.450 1.00 0.00 H ATOM 4146 HA
LEU B 90 -8.843 43.446 22.688 1.00 0.00 H ATOM 4147 1HB LEU B 90
-8.289 45.492 20.463 1.00 0.00 H ATOM 4148 2HB LEU B 90 -7.683
45.608 22.117 1.00 0.00 H ATOM 4149 HG LEU B 90 -10.652 45.497
21.379 1.00 0.00 H ATOM 4150 1HD1 LEU B 90 -11.099 45.356 23.615
1.00 0.00 H ATOM 4151 2HD1 LEU B 90 -9.407 44.997 23.914 1.00 0.00
H ATOM 4152 3HD1 LEU B 90 -9.921 46.663 24.002 1.00 0.00 H ATOM
4153 1HD2 LEU B 90 -10.779 47.894 21.677 1.00 0.00 H ATOM 4154 2HD2
LEU B 90 -9.068 47.981 22.192 1.00 0.00 H ATOM 4155 3HD2 LEU B 90
-9.494 47.554 20.513 1.00 0.00 H ATOM 4156 N GLN B 91 -10.719
42.628 21.185 1.00 0.11 N ATOM 4157 CA GLN B 91 -11.640 41.998
20.289 1.00 0.11 C ATOM 4158 C GLN B 91 -12.857 42.848 20.152 1.00
0.11 C ATOM 4159 O GLN B 91 -13.277 43.520 21.093 1.00 0.11 O ATOM
4160 CB GLN B 91 -12.096 40.612 20.782 1.00 0.11 C ATOM 4161 CG GLN
B 91 -10.956 39.593 20.886 1.00 0.11 C ATOM 4162 CD GLN B 91
-11.531 38.284 21.415 1.00 0.11 C ATOM 4163 OE1 GLN B 91 -12.410
38.286 22.275 1.00 0.11 O ATOM 4164 NE2 GLN B 91 -11.026 37.136
20.890 1.00 0.11 N ATOM 4165 H GLN B 91 -10.874 42.521 22.183 1.00
0.00 H ATOM 4166 HA GLN B 91 -11.163 41.837 19.308 1.00 0.00 H ATOM
4167 1HB GLN B 91 -12.816 40.237 20.042 1.00 0.00 H ATOM 4168 2HB
GLN B 91 -12.614 40.719 21.748 1.00 0.00 H ATOM 4169 1HG GLN B 91
-10.184 39.916 21.606 1.00 0.00 H ATOM 4170 2HG GLN B 91 -10.464
39.476 19.910 1.00 0.00 H ATOM 4171 1HE2 GLN B 91 -10.465 37.207
20.058 1.00 0.00 H ATOM 4172 2HE2 GLN B 91 -11.449 36.265 21.152
1.00 0.00 H ATOM 4173 N ALA B 92 -13.435 42.855 18.936 1.00 0.18 N
ATOM 4174 CA ALA B 92 -14.630 43.605 18.701 1.00 0.18 C ATOM 4175 C
ALA B 92 -15.533 42.758 17.870 1.00 0.18 C ATOM 4176 O ALA B 92
-15.082 41.941 17.072 1.00 0.18 O ATOM 4177 CB ALA B 92 -14.397
44.910 17.923 1.00 0.18 C ATOM 4178 H ALA B 92 -13.113 42.309
18.152 1.00 0.00 H ATOM 4179 HA ALA B 92 -15.098 43.889 19.650 1.00
0.00 H ATOM 4180 1HB ALA B 92 -15.350 45.450 17.815 1.00 0.00 H
ATOM 4181 2HB ALA B 92 -13.693 45.562 18.463 1.00 0.00 H ATOM 4182
3HB ALA B 92 -13.990 44.720 16.918 1.00 0.00 H ATOM 4183 N SER B 93
-16.852 42.907 18.076 1.00 0.25 N ATOM 4184 CA SER B 93 -17.796
42.156 17.309 1.00 0.25 C ATOM 4185 C SER B 93 -17.756 42.639
15.893 1.00 0.25 C ATOM 4186 O SER B 93 -17.703 41.842 14.957 1.00
0.25 O ATOM 4187 CB SER B 93 -19.230 42.324 17.826 1.00 0.25 C ATOM
4188 OG SER B 93 -20.123 41.558 17.034 1.00 0.25 O ATOM 4189 H SER
B 93 -17.207 43.526 18.787 1.00 0.00 H ATOM 4190 HA SER B 93
-17.536 41.086 17.324 1.00 0.00 H ATOM 4191 1HB SER B 93 -19.542
43.384 17.844 1.00 0.00 H ATOM 4192 2HB SER B 93 -19.314 41.932
18.849 1.00 0.00 H ATOM 4193 HG SER B 93 -20.011 41.846 16.114 1.00
0.00 H ATOM 4194 N ALA B 94 -17.769 43.973 15.694 1.00 0.19 N ATOM
4195 CA ALA B 94 -17.777 44.482 14.351 1.00 0.19 C ATOM 4196 C ALA
B 94 -16.919 45.705 14.290 1.00 0.19 C ATOM 4197 O ALA B 94 -16.764
46.431 15.271 1.00 0.19 O ATOM 4198 CB ALA B 94 -19.179 44.880
13.860 1.00 0.19 C ATOM 4199 H ALA B 94 -17.658 44.650 16.428 1.00
0.00 H ATOM 4200 HA ALA B 94 -17.356 43.726 13.667 1.00 0.00 H ATOM
4201 1HB ALA B 94 -19.117 45.246 12.823 1.00 0.00 H ATOM 4202 2HB
ALA B 94 -19.858 44.014 13.878 1.00 0.00 H ATOM 4203 3HB ALA B 94
-19.612 45.677 14.484 1.00 0.00 H ATOM 4204 N GLU B 95 -16.301
45.923 13.114 1.00 0.12 N ATOM 4205 CA GLU B 95 -15.454 47.050
12.861 1.00 0.12 C ATOM 4206 C GLU B 95 -16.282 48.297 12.802 1.00
0.12 C ATOM 4207 O GLU B 95 -15.920 49.321 13.378 1.00 0.12 O ATOM
4208 CB GLU B 95 -14.711 46.900 11.522 1.00 0.12 C ATOM 4209 CG GLU
B 95 -13.753 45.702 11.506 1.00 0.12 C ATOM 4210 CD GLU B 95
-13.312 45.440 10.073 1.00 0.12 C ATOM 4211 OE1 GLU B 95 -13.538
46.328 9.208 1.00 0.12 O ATOM 4212 OE2 GLU B 95 -12.742 44.344
9.826 1.00 0.12 O1- ATOM 4213 H GLU B 95 -16.316 45.238 12.374 1.00
0.00 H ATOM 4214 HA GLU B 95 -14.722 47.164 13.677 1.00 0.00 H ATOM
4215 1HB GLU B 95 -14.146 47.836 11.359 1.00 0.00 H ATOM 4216 2HB
GLU B 95 -15.448 46.820 10.703 1.00 0.00 H ATOM 4217 1HG GLU B 95
-14.200 44.777 11.906 1.00 0.00 H ATOM 4218 2HG GLU B 95 -12.869
45.899 12.134 1.00 0.00 H ATOM 4219 N VAL B 96 -17.436 48.236
12.110 1.00 0.11 N ATOM 4220 CA VAL B 96 -18.234 49.417 11.956 1.00
0.11 C ATOM 4221 C VAL B 96 -19.504 49.229 12.709 1.00 0.11 C ATOM
4222 O VAL B 96 -20.025 48.119 12.813 1.00 0.11 O ATOM 4223 CB VAL
B 96 -18.599 49.704 10.531 1.00 0.11 C ATOM 4224 CG1 VAL B 96
-19.514 50.942 10.495 1.00 0.11 C ATOM 4225 CG2 VAL B 96 -17.299
49.864 9.726 1.00 0.11 C ATOM 4226 H VAL B 96 -17.804 47.378 11.744
1.00 0.00 H ATOM 4227 HA VAL B 96 -17.676 50.279 12.332 1.00 0.00 H
ATOM 4228 HB VAL B 96 -19.167 48.857 10.104 1.00 0.00 H ATOM 4229
1HG1 VAL B 96 -19.610 51.278 9.448 1.00 0.00 H ATOM 4230 2HG1 VAL B
96 -20.517 50.663 10.851 1.00 0.00 H ATOM 4231 3HG1 VAL B 96
-19.099 51.777 11.077 1.00 0.00 H ATOM 4232 1HG2 VAL B 96 -17.491
50.218 8.699 1.00 0.00 H ATOM 4233 2HG2 VAL B 96 -16.616 50.584
10.198 1.00 0.00 H ATOM 4234 3HG2 VAL B 96 -16.754 48.909 9.632
1.00 0.00 H ATOM 4235 N VAL B 97 -20.028 50.335 13.268 1.00 0.10 N
ATOM 4236 CA VAL B 97 -21.230 50.266 14.039 1.00 0.10 C ATOM 4237 C
VAL B 97 -22.100 51.399 13.620 1.00 0.10 C ATOM 4238 O VAL B 97
-21.654 52.332 12.957 1.00 0.10 O ATOM 4239 CB VAL B 97 -20.992
50.434 15.511 1.00 0.10 C ATOM 4240 CG1 VAL B 97 -20.128 49.263
16.004 1.00 0.10 C ATOM 4241 CG2 VAL B 97 -20.363 51.816 15.752
1.00 0.10 C ATOM 4242 H VAL B 97 -19.530 51.212 13.277 1.00 0.00 H
ATOM 4243 HA VAL B 97 -21.758 49.333 13.789 1.00 0.00 H ATOM 4244
HB VAL B 97 -21.926 50.484 16.060 1.00 0.00 H ATOM 4245 1HG1 VAL B
97 -20.116 49.203 17.104 1.00 0.00 H ATOM 4246 2HG1 VAL B 97
-20.458 48.283 15.626 1.00 0.00 H ATOM 4247 3HG1 VAL B 97 -19.079
49.385 15.681 1.00 0.00 H ATOM 4248 1HG2 VAL B 97 -20.214 51.976
16.835 1.00 0.00 H ATOM 4249 2HG2 VAL B 97 -19.366 51.909 15.298
1.00 0.00 H ATOM 4250 3HG2 VAL B 97 -21.003 52.645 15.413 1.00 0.00
H ATOM 4251 N MET B 98 -23.386 51.330 14.004 1.00 0.12 N ATOM 4252
CA MET B 98 -24.315 52.369 13.688 1.00 0.12 C ATOM 4253 C MET B 98
-24.355 53.226 14.909 1.00 0.12 C ATOM 4254 O MET B 98 -24.093
52.749 16.012 1.00 0.12 O ATOM 4255 CB MET B 98 -25.737 51.837
13.442 1.00 0.12 C ATOM 4256 CG MET B 98 -25.810 50.833 12.286 1.00
0.12 C ATOM 4257 SD MET B 98 -25.466 51.524 10.639 1.00 0.12 S ATOM
4258 CE MET B 98 -27.170 52.062 10.325 1.00 0.12 C ATOM 4259 H MET
B 98 -23.734 50.567 14.559 1.00 0.00 H ATOM 4260 HA MET B 98
-24.011 52.927 12.813 1.00 0.00 H ATOM 4261 1HB MET B 98 -26.406
52.694 13.257 1.00 0.00 H ATOM 4262 2HB MET B 98 -26.107 51.339
14.356 1.00 0.00 H ATOM 4263 1HG MET B 98 -26.805 50.356 12.241
1.00 0.00 H ATOM 4264 2HG MET B 98 -25.093 50.010 12.444 1.00 0.00
H ATOM 4265 1HE MET B 98 -27.192 52.555 9.342 1.00 0.00 H ATOM 4266
2HE MET B 98 -27.854 51.201 10.300 1.00 0.00 H ATOM 4267 3HE MET B
98 -27.497 52.785 11.086 1.00 0.00 H ATOM 4268 N GLU B 99 -24.653
54.527 14.755 1.00 0.10 N ATOM 4269 CA GLU B 99 -24.662 55.336
15.936 1.00 0.10 C ATOM 4270 C GLU B 99 -25.806 54.890 16.779 1.00
0.10 C ATOM 4271 O GLU B 99 -26.866 54.525 16.272 1.00 0.10 O ATOM
4272 CB GLU B 99 -24.838 56.844 15.682 1.00 0.10 C ATOM 4273 CG GLU
B 99 -24.757 57.670 16.970 1.00 0.10 C ATOM 4274 CD GLU B 99
-24.956 59.140 16.629 1.00 0.10 C ATOM 4275 OE1 GLU B 99 -24.323
59.619 15.652 1.00 0.10 O ATOM 4276 OE2 GLU B 99 -25.752 59.803
17.347 1.00 0.10 O1- ATOM 4277 H GLU B 99 -24.979 54.937 13.900
1.00 0.00 H ATOM 4278 HA GLU B 99 -23.696 55.198 16.459 1.00 0.00 H
ATOM 4279 1HB GLU B 99 -25.788 57.005 15.155 1.00 0.00 H ATOM 4280
2HB GLU B 99 -23.975 57.166 15.117 1.00 0.00 H ATOM 4281 1HG GLU B
99 -23.715 57.578 17.265 1.00 0.00 H ATOM 4282 2HG GLU B 99 -25.443
57.385 17.776 1.00 0.00 H ATOM 4283 N GLY B 100 -25.599 54.893
18.108 1.00 0.20 N ATOM 4284 CA GLY B 100 -26.641 54.528 19.014
1.00 0.20 C ATOM 4285 C GLY B 100 -26.474 53.096 19.396 1.00 0.20 C
ATOM 4286 O GLY B 100 -27.034 52.656 20.399 1.00 0.20 O ATOM 4287 H
GLY B 100 -24.793 55.390 18.492 1.00 0.00 H ATOM 4288 1HA GLY B 100
-27.635 54.668 18.562 1.00 0.00 H ATOM 4289 2HA GLY B 100 -26.586
55.155 19.915 1.00 0.00 H ATOM 4290 N GLN B 101 -25.696 52.315
18.624 1.00 0.50 N ATOM 4291 CA GLN B 101 -25.580 50.950 19.038
1.00 0.50 C ATOM 4292 C GLN B 101 -24.520 50.860 20.078 1.00 0.50 C
ATOM 4293 O GLN B 101 -23.614 51.689 20.161 1.00 0.50 O ATOM 4294
CB GLN B 101 -25.311 49.923 17.920 1.00 0.50 C ATOM 4295 CG GLN B
101 -23.985 50.050 17.175 1.00 0.50 C ATOM 4296 CD GLN B 101
-23.925 48.857 16.224 1.00 0.50 C ATOM 4297 OE1 GLN B 101 -22.862
48.448 15.763 1.00 0.50 O ATOM 4298 NE2 GLN B 101 -25.114 48.265
15.932 1.00 0.50 N ATOM 4299 H GLN B 101 -25.185 52.658 17.818 1.00
0.00 H ATOM 4300 HA GLN B 101 -26.589 50.647 19.360 1.00 0.00 H
ATOM 4301 1HB GLN B 101 -26.170 50.034 17.236 1.00 0.00 H ATOM 4302
2HB GLN B 101 -25.362 48.930 18.402 1.00 0.00 H ATOM 4303 1HG GLN B
101 -23.127 49.980 17.861 1.00 0.00 H ATOM 4304 2HG GLN B 101
-23.855 50.850 16.515 1.00 0.00 H ATOM 4305 1HE2 GLN B 101 -25.978
48.551 16.350 1.00 0.00 H ATOM 4306 2HE2 GLN B 101 -25.070 47.437
15.362 1.00 0.00 H ATOM 4307 N PRO B 102 -24.671 49.879 20.918 1.00
0.57 N ATOM 4308 CA PRO B 102 -23.702 49.696 21.956 1.00 0.57 C
ATOM 4309 C PRO B 102 -22.464 49.090 21.396 1.00 0.57 C ATOM 4310 O
PRO B 102 -22.552 48.324 20.440 1.00 0.57 O ATOM 4311 CB PRO B 102
-24.375 48.836 23.023 1.00 0.57 C ATOM 4312 CG PRO B 102 -25.870
49.147 22.846 1.00 0.57 C ATOM 4313 CD PRO B 102 -26.007 49.500
21.355 1.00 0.57 C ATOM 4314 HA PRO B 102 -23.501 50.683 22.400
1.00 0.00 H ATOM 4315 1HB PRO B 102 -23.985 49.030 24.034 1.00 0.00
H ATOM 4316 2HB PRO B 102 -24.196 47.767 22.814 1.00 0.00 H ATOM
4317 1HG PRO B 102 -26.136 50.022 23.462 1.00 0.00 H ATOM 4318 2HG
PRO B 102 -26.538 48.328 23.154 1.00 0.00 H ATOM 4319 1HD PRO B 102
-26.352 48.634 20.768 1.00 0.00 H ATOM 4320 2HD PRO B 102 -26.737
50.310 21.257 1.00 0.00 H ATOM 4321 N LEU B 103 -21.299 49.426
21.973 1.00 0.26 N ATOM 4322 CA LEU B 103 -20.081 48.841 21.517
1.00 0.26 C ATOM 4323 C LEU B 103 -19.597 47.982 22.628 1.00 0.26 C
ATOM 4324 O LEU B 103 -19.568 48.404 23.782 1.00 0.26 O ATOM 4325
CB LEU B 103 -18.971 49.863 21.213 1.00 0.26 C ATOM 4326 CG LEU B
103 -17.661 49.217 20.720 1.00 0.26 C ATOM 4327 CD1 LEU B 103
-17.856 48.516 19.366 1.00 0.26 C ATOM 4328 CD2 LEU B 103 -16.509
50.235 20.709 1.00 0.26 C ATOM 4329 H LEU B 103 -21.251 50.111
22.718 1.00 0.00 H ATOM 4330 HA LEU B 103 -20.277 48.257 20.607
1.00 0.00 H ATOM 4331 1HB LEU B 103 -18.745 50.421 22.129 1.00 0.00
H ATOM 4332 2HB LEU B 103 -19.330 50.595 20.468 1.00 0.00 H ATOM
4333 HG LEU B 103 -17.359 48.441 21.447 1.00 0.00 H ATOM 4334 1HD1
LEU B 103 -16.913 48.068 19.010 1.00 0.00 H ATOM 4335 2HD1 LEU B
103 -18.596 47.704 19.406 1.00 0.00 H ATOM 4336 3HD1 LEU B 103
-18.182 49.236 18.598 1.00 0.00 H ATOM 4337 1HD2 LEU B 103 -15.604
49.827 20.237 1.00 0.00 H ATOM 4338 2HD2 LEU B 103 -16.779 51.152
20.160 1.00 0.00 H ATOM 4339 3HD2 LEU B 103 -16.227 50.511 21.735
1.00 0.00 H ATOM 4340 N PHE B 104 -19.234 46.729 22.312 1.00 0.08 N
ATOM 4341 CA PHE B 104 -18.730 45.879 23.344 1.00 0.08 C ATOM 4342
C PHE B 104 -17.343 45.523 22.936 1.00 0.08 C ATOM 4343 O PHE B 104
-17.099 45.161 21.785 1.00 0.08 O ATOM 4344 CB PHE B 104 -19.527
44.575 23.513 1.00 0.08 C ATOM 4345 CG PHE B 104 -18.986 43.851
24.699 1.00 0.08 C ATOM 4346 CD1 PHE B 104 -19.376 44.202 25.972
1.00 0.08 C ATOM 4347 CD2 PHE B 104 -18.097 42.814 24.540 1.00 0.08
C ATOM 4348 CE1 PHE B 104 -18.881 43.533 27.066 1.00 0.08 C ATOM
4349 CE2 PHE B 104 -17.597 42.141 25.630 1.00 0.08 C ATOM 4350 CZ
PHE B 104 -17.990 42.502 26.896 1.00 0.08 C ATOM 4351 H PHE B 104
-19.164 46.378 21.373 1.00 0.00 H ATOM 4352 HA PHE B 104 -18.730
46.402 24.309 1.00 0.00 H ATOM 4353 1HB PHE B 104 -19.479 43.969
22.596 1.00 0.00 H ATOM 4354 2HB PHE B 104 -20.591 44.822 23.665
1.00 0.00 H ATOM 4355 HD1 PHE B 104 -20.096 45.005 26.104 1.00 0.00
H ATOM 4356 HD2 PHE B 104 -18.020 42.448 23.527 1.00 0.00 H ATOM
4357 HE1 PHE B 104 -19.224 43.802 28.062 1.00 0.00 H ATOM 4358 HE2
PHE B 104 -16.936 41.303 25.591 1.00 0.00 H ATOM 4359 HZ PHE B 104
-17.766 41.863 27.735 1.00 0.00 H ATOM 4360 N LEU B 105 -16.385
45.650 23.872 1.00 0.10 N
ATOM 4361 CA LEU B 105 -15.028 45.325 23.562 1.00 0.10 C ATOM 4362
C LEU B 105 -14.558 44.396 24.624 1.00 0.10 C ATOM 4363 O LEU B 105
-15.108 44.362 25.724 1.00 0.10 O ATOM 4364 CB LEU B 105 -14.079
46.536 23.569 1.00 0.10 C ATOM 4365 CG LEU B 105 -14.388 47.582
22.481 1.00 0.10 C ATOM 4366 CD1 LEU B 105 -13.388 48.748 22.534
1.00 0.10 C ATOM 4367 CD2 LEU B 105 -14.485 46.936 21.090 1.00 0.10
C ATOM 4368 H LEU B 105 -16.576 45.939 24.827 1.00 0.00 H ATOM 4369
HA LEU B 105 -14.968 44.805 22.597 1.00 0.00 H ATOM 4370 1HB LEU B
105 -13.123 46.086 23.234 1.00 0.00 H ATOM 4371 2HB LEU B 105
-13.791 46.969 24.481 1.00 0.00 H ATOM 4372 HG LEU B 105 -15.382
48.018 22.698 1.00 0.00 H ATOM 4373 1HD1 LEU B 105 -13.415 49.365
21.621 1.00 0.00 H ATOM 4374 2HD1 LEU B 105 -13.615 49.414 23.383
1.00 0.00 H ATOM 4375 3HD1 LEU B 105 -12.365 48.392 22.683 1.00
0.00 H ATOM 4376 1HD2 LEU B 105 -14.787 47.681 20.341 1.00 0.00 H
ATOM 4377 2HD2 LEU B 105 -13.499 46.550 20.781 1.00 0.00 H ATOM
4378 3HD2 LEU B 105 -15.189 46.111 20.996 1.00 0.00 H ATOM 4379 N
ARG B 106 -13.530 43.592 24.307 1.00 0.15 N ATOM 4380 CA ARG B 106
-13.059 42.656 25.276 1.00 0.15 C ATOM 4381 C ARG B 106 -11.579
42.563 25.130 1.00 0.15 C ATOM 4382 O ARG B 106 -11.049 42.581
24.020 1.00 0.15 O ATOM 4383 CB ARG B 106 -13.663 41.262 25.034
1.00 0.15 C ATOM 4384 CG ARG B 106 -13.241 40.162 26.004 1.00 0.15
C ATOM 4385 CD ARG B 106 -14.061 38.888 25.787 1.00 0.15 C ATOM
4386 NE ARG B 106 -13.541 37.832 26.698 1.00 0.15 N1+ ATOM 4387 CZ
ARG B 106 -12.993 36.702 26.169 1.00 0.15 C ATOM 4388 NH1 ARG B 106
-12.935 36.556 24.813 1.00 0.15 N ATOM 4389 NH2 ARG B 106 -12.531
35.718 26.995 1.00 0.15 N ATOM 4390 H ARG B 106 -13.089 43.585
23.398 1.00 0.00 H ATOM 4391 HA ARG B 106 -13.331 42.978 26.288
1.00 0.00 H ATOM 4392 1HB ARG B 106 -13.453 40.935 24.002 1.00 0.00
H ATOM 4393 2HB ARG B 106 -14.740 41.426 25.150 1.00 0.00 H ATOM
4394 1HG ARG B 106 -13.146 40.446 27.059 1.00 0.00 H ATOM 4395 2HG
ARG B 106 -12.200 39.888 25.736 1.00 0.00 H ATOM 4396 1HD ARG B 106
-13.950 38.632 24.738 1.00 0.00 H ATOM 4397 2HD ARG B 106 -15.136
39.011 25.994 1.00 0.00 H ATOM 4398 HE ARG B 106 -13.935 37.715
27.606 1.00 0.00 H ATOM 4399 1HH1 ARG B 106 -12.968 37.348 24.200
1.00 0.00 H ATOM 4400 2HH1 ARG B 106 -12.382 35.811 24.442 1.00
0.00 H ATOM 4401 1HH2 ARG B 106 -12.173 34.859 26.638 1.00 0.00 H
ATOM 4402 2HH2 ARG B 106 -12.478 35.864 27.979 1.00 0.00 H ATOM
4403 N CYS B 107 -10.862 42.482 26.266 1.00 0.16 N ATOM 4404 CA CYS
B 107 -9.446 42.306 26.188 1.00 0.16 C ATOM 4405 C CYS B 107 -9.261
40.846 26.416 1.00 0.16 C ATOM 4406 O CYS B 107 -9.650 40.320
27.458 1.00 0.16 O ATOM 4407 CB CYS B 107 -8.663 43.074 27.268 1.00
0.16 C ATOM 4408 SG CYS B 107 -9.006 44.857 27.207 1.00 0.16 S ATOM
4409 H CYS B 107 -11.264 42.454 27.191 1.00 0.00 H ATOM 4410 HA CYS
B 107 -9.062 42.647 25.214 1.00 0.00 H ATOM 4411 1HB CYS B 107
-7.591 42.892 27.084 1.00 0.00 H ATOM 4412 2HB CYS B 107 -8.887
42.711 28.282 1.00 0.00 H ATOM 4413 N HIS B 108 -8.681 40.141
25.429 1.00 0.11 N ATOM 4414 CA HIS B 108 -8.593 38.719 25.557 1.00
0.11 C ATOM 4415 C HIS B 108 -7.159 38.316 25.545 1.00 0.11 C ATOM
4416 O HIS B 108 -6.360 38.829 24.763 1.00 0.11 O ATOM 4417 CB HIS
B 108 -9.321 37.991 24.412 1.00 0.11 C ATOM 4418 CG HIS B 108
-9.314 36.494 24.517 1.00 0.11 C ATOM 4419 ND1 HIS B 108 -8.352
35.693 23.946 1.00 0.11 N ATOM 4420 CD2 HIS B 108 -10.189 35.649
25.126 1.00 0.11 C ATOM 4421 CE1 HIS B 108 -8.693 34.410 24.231
1.00 0.11 C ATOM 4422 NE2 HIS B 108 -9.799 34.333 24.946 1.00 0.11
N ATOM 4423 H HIS B 108 -8.343 40.550 24.563 1.00 0.00 H ATOM 4424
HA HIS B 108 -9.067 38.390 26.494 1.00 0.00 H ATOM 4425 1HB HIS B
108 -8.903 38.313 23.443 1.00 0.00 H ATOM 4426 2HB HIS B 108
-10.372 38.319 24.407 1.00 0.00 H ATOM 4427 HD2 HIS B 108 -10.626
35.988 26.029 1.00 0.00 H ATOM 4428 HE1 HIS B 108 -7.908 33.691
24.152 1.00 0.00 H ATOM 4429 HE2 HIS B 108 -9.908 33.580 25.609
1.00 0.00 H ATOM 4430 N GLY B 109 -6.805 37.367 26.433 1.00 0.09 N
ATOM 4431 CA GLY B 109 -5.456 36.899 26.515 1.00 0.09 C ATOM 4432 C
GLY B 109 -5.417 35.556 25.871 1.00 0.09 C ATOM 4433 O GLY B 109
-6.414 34.837 25.839 1.00 0.09 O ATOM 4434 H GLY B 109 -7.478
36.848 26.971 1.00 0.00 H ATOM 4435 1HA GLY B 109 -5.161 36.786
27.574 1.00 0.00 H ATOM 4436 2HA GLY B 109 -4.766 37.619 26.058
1.00 0.00 H ATOM 4437 N TRP B 110 -4.241 35.184 25.339 1.00 0.32 N
ATOM 4438 CA TRP B 110 -4.097 33.932 24.665 1.00 0.32 C ATOM 4439 C
TRP B 110 -4.162 32.847 25.691 1.00 0.32 C ATOM 4440 O TRP B 110
-3.707 33.008 26.822 1.00 0.32 O ATOM 4441 CB TRP B 110 -2.767
33.840 23.890 1.00 0.32 C ATOM 4442 CG TRP B 110 -2.534 32.551
23.142 1.00 0.32 C ATOM 4443 CD1 TRP B 110 -3.146 32.070 22.021
1.00 0.32 C ATOM 4444 CD2 TRP B 110 -1.525 31.596 23.495 1.00 0.32
C ATOM 4445 NE1 TRP B 110 -2.583 30.869 21.657 1.00 0.32 N ATOM
4446 CE2 TRP B 110 -1.580 30.568 22.553 1.00 0.32 C ATOM 4447 CE3
TRP B 110 -0.621 31.578 24.517 1.00 0.32 C ATOM 4448 CZ2 TRP B 110
-0.729 29.502 22.620 1.00 0.32 C ATOM 4449 CZ3 TRP B 110 0.236
30.504 24.583 1.00 0.32 C ATOM 4450 CH2 TRP B 110 0.183 29.486
23.653 1.00 0.32 C ATOM 4451 H TRP B 110 -3.501 35.873 25.213 1.00
0.00 H ATOM 4452 HA TRP B 110 -4.922 33.828 23.933 1.00 0.00 H ATOM
4453 1HB TRP B 110 -1.929 34.040 24.572 1.00 0.00 H ATOM 4454 2HB
TRP B 110 -2.766 34.667 23.167 1.00 0.00 H ATOM 4455 HD1 TRP B 110
-4.013 32.458 21.524 1.00 0.00 H ATOM 4456 HE1 TRP B 110 -3.077
30.217 21.085 1.00 0.00 H ATOM 4457 HE3 TRP B 110 -0.604 32.378
25.237 1.00 0.00 H ATOM 4458 HZ2 TRP B 110 -0.771 28.699 21.889
1.00 0.00 H ATOM 4459 HZ3 TRP B 110 1.037 30.521 25.317 1.00 0.00 H
ATOM 4460 HH2 TRP B 110 0.902 28.670 23.710 1.00 0.00 H ATOM 4461 N
ARG B 111 -4.775 31.709 25.311 1.00 0.53 N ATOM 4462 CA ARG B 111
-4.933 30.586 26.189 1.00 0.53 C ATOM 4463 C ARG B 111 -5.683
31.000 27.413 1.00 0.53 C ATOM 4464 O ARG B 111 -5.653 30.300
28.425 1.00 0.53 O ATOM 4465 CB ARG B 111 -3.620 29.933 26.655 1.00
0.53 C ATOM 4466 CG ARG B 111 -3.020 28.970 25.633 1.00 0.53 C ATOM
4467 CD ARG B 111 -2.053 27.949 26.245 1.00 0.53 C ATOM 4468 NE ARG
B 111 -0.754 28.629 26.508 1.00 0.53 N1+ ATOM 4469 CZ ARG B 111
0.186 28.032 27.299 1.00 0.53 C ATOM 4470 NH1 ARG B 111 -0.095
26.849 27.921 1.00 0.53 N ATOM 4471 NH2 ARG B 111 1.396 28.633
27.493 1.00 0.53 N ATOM 4472 H ARG B 111 -5.186 31.627 24.389 1.00
0.00 H ATOM 4473 HA ARG B 111 -5.583 29.848 25.683 1.00 0.00 H ATOM
4474 1HB ARG B 111 -3.792 29.342 27.570 1.00 0.00 H ATOM 4475 2HB
ARG B 111 -2.899 30.707 26.910 1.00 0.00 H ATOM 4476 1HG ARG B 111
-2.557 29.498 24.791 1.00 0.00 H ATOM 4477 2HG ARG B 111 -3.855
28.394 25.192 1.00 0.00 H ATOM 4478 1HD ARG B 111 -1.871 27.088
25.580 1.00 0.00 H ATOM 4479 2HD ARG B 111 -2.462 27.574 27.198
1.00 0.00 H ATOM 4480 HE ARG B 111 -0.400 29.179 25.751 1.00 0.00 H
ATOM 4481 1HH1 ARG B 111 -0.987 26.418 27.837 1.00 0.00 H ATOM 4482
2HH1 ARG B 111 0.584 26.383 28.480 1.00 0.00 H ATOM 4483 1HH2 ARG B
111 2.095 28.219 28.070 1.00 0.00 H ATOM 4484 2HH2 ARG B 111 1.585
29.543 27.140 1.00 0.00 H ATOM 4485 N ASN B 112 -6.402 32.134
27.343 1.00 0.33 N ATOM 4486 CA ASN B 112 -7.191 32.586 28.452 1.00
0.33 C ATOM 4487 C ASN B 112 -6.360 32.626 29.693 1.00 0.33 C ATOM
4488 O ASN B 112 -6.800 32.181 30.754 1.00 0.33 O ATOM 4489 CB ASN
B 112 -8.409 31.688 28.734 1.00 0.33 C ATOM 4490 CG ASN B 112
-9.405 31.882 27.605 1.00 0.33 C ATOM 4491 OD1 ASN B 112 -9.721
33.014 27.241 1.00 0.33 O ATOM 4492 ND2 ASN B 112 -9.908 30.756
27.031 1.00 0.33 N ATOM 4493 H ASN B 112 -6.362 32.724 26.520 1.00
0.00 H ATOM 4494 HA ASN B 112 -7.515 33.623 28.253 1.00 0.00 H ATOM
4495 1HB ASN B 112 -8.936 32.044 29.637 1.00 0.00 H ATOM 4496 2HB
ASN B 112 -8.129 30.637 28.898 1.00 0.00 H ATOM 4497 1HD2 ASN B 112
-9.555 29.853 27.290 1.00 0.00 H ATOM 4498 2HD2 ASN B 112 -10.398
30.864 26.155 1.00 0.00 H ATOM 4499 N TRP B 113 -5.133 33.171
29.612 1.00 0.13 N ATOM 4500 CA TRP B 113 -4.351 33.236 30.808 1.00
0.13 C ATOM 4501 C TRP B 113 -4.945 34.304 31.665 1.00 0.13 C ATOM
4502 O TRP B 113 -5.619 35.209 31.177 1.00 0.13 O ATOM 4503 CB TRP
B 113 -2.864 33.550 30.572 1.00 0.13 C ATOM 4504 CG TRP B 113
-2.109 32.435 29.884 1.00 0.13 C ATOM 4505 CD1 TRP B 113 -1.666
32.352 28.595 1.00 0.13 C ATOM 4506 CD2 TRP B 113 -1.737 31.203
30.524 1.00 0.13 C ATOM 4507 NE1 TRP B 113 -1.030 31.149 28.395
1.00 0.13 N ATOM 4508 CE2 TRP B 113 -1.071 30.431 29.574 1.00 0.13
C ATOM 4509 CE3 TRP B 113 -1.939 30.749 31.798 1.00 0.13 C ATOM
4510 CZ2 TRP B 113 -0.593 29.190 29.891 1.00 0.13 C ATOM 4511 CZ3
TRP B 113 -1.451 29.499 32.110 1.00 0.13 C ATOM 4512 CH2 TRP B 113
-0.791 28.733 31.174 1.00 0.13 C ATOM 4513 H TRP B 113 -4.706
33.392 28.722 1.00 0.00 H ATOM 4514 HA TRP B 113 -4.416 32.264
31.331 1.00 0.00 H ATOM 4515 1HB TRP B 113 -2.398 33.746 31.554
1.00 0.00 H ATOM 4516 2HB TRP B 113 -2.768 34.490 30.007 1.00 0.00
H ATOM 4517 HD1 TRP B 113 -1.720 33.120 27.844 1.00 0.00 H ATOM
4518 HE1 TRP B 113 -0.986 30.689 27.511 1.00 0.00 H ATOM 4519 HE3
TRP B 113 -2.453 31.342 32.547 1.00 0.00 H ATOM 4520 HZ2 TRP B 113
0.140 28.651 29.363 1.00 0.00 H ATOM 4521 HZ3 TRP B 113 -1.587
29.113 33.118 1.00 0.00 H ATOM 4522 HH2 TRP B 113 -0.388 27.770
31.480 1.00 0.00 H ATOM 4523 N ASP B 114 -4.712 34.218 32.988 1.00
0.12 N ATOM 4524 CA ASP B 114 -5.293 35.164 33.895 1.00 0.12 C ATOM
4525 C ASP B 114 -4.813 36.522 33.513 1.00 0.12 C ATOM 4526 O ASP B
114 -3.627 36.729 33.263 1.00 0.12 O ATOM 4527 CB ASP B 114 -4.874
34.945 35.357 1.00 0.12 C ATOM 4528 CG ASP B 114 -5.445 33.616
35.823 1.00 0.12 C ATOM 4529 OD1 ASP B 114 -6.688 33.434 35.731
1.00 0.12 O ATOM 4530 OD2 ASP B 114 -4.640 32.765 36.285 1.00 0.12
O1- ATOM 4531 H ASP B 114 -4.235 33.453 33.434 1.00 0.00 H ATOM
4532 HA ASP B 114 -6.396 35.103 33.822 1.00 0.00 H ATOM 4533 1HB
ASP B 114 -5.326 35.762 35.943 1.00 0.00 H ATOM 4534 2HB ASP B 114
-3.782 34.988 35.482 1.00 0.00 H ATOM 4535 N VAL B 115 -5.746
37.488 33.447 1.00 0.21 N ATOM 4536 CA VAL B 115 -5.368 38.823
33.098 1.00 0.21 C ATOM 4537 C VAL B 115 -5.975 39.733 34.112 1.00
0.21 C ATOM 4538 O VAL B 115 -7.072 39.488 34.611 1.00 0.21 O ATOM
4539 CB VAL B 115 -5.880 39.263 31.759 1.00 0.21 C ATOM 4540 CG1
VAL B 115 -5.413 40.708 31.508 1.00 0.21 C ATOM 4541 CG2 VAL B 115
-5.402 38.262 30.694 1.00 0.21 C ATOM 4542 H VAL B 115 -6.699
37.343 33.725 1.00 0.00 H ATOM 4543 HA VAL B 115 -4.271 38.918
33.117 1.00 0.00 H ATOM 4544 HB VAL B 115 -6.981 39.270 31.744 1.00
0.00 H ATOM 4545 1HG1 VAL B 115 -5.622 41.014 30.468 1.00 0.00 H
ATOM 4546 2HG1 VAL B 115 -5.940 41.434 32.142 1.00 0.00 H ATOM 4547
3HG1 VAL B 115 -4.326 40.819 31.656 1.00 0.00 H ATOM 4548 1HG2 VAL
B 115 -6.242 37.632 30.360 1.00 0.00 H ATOM 4549 2HG2 VAL B 115
-5.022 38.760 29.788 1.00 0.00 H ATOM 4550 3HG2 VAL B 115 -4.626
37.571 31.037 1.00 0.00 H ATOM 4551 N TYR B 116 -5.249 40.808
34.455 1.00 0.44 N ATOM 4552 CA TYR B 116 -5.738 41.756 35.407 1.00
0.44 C ATOM 4553 C TYR B 116 -5.192 43.082 34.997 1.00 0.44 C ATOM
4554 O TYR B 116 -4.387 43.164 34.070 1.00 0.44 O ATOM 4555 CB TYR
B 116 -5.271 41.458 36.836 1.00 0.44 C ATOM 4556 CG TYR B 116
-3.794 41.347 36.746 1.00 0.44 C ATOM 4557 CD1 TYR B 116 -2.990
42.447 36.891 1.00 0.44 C ATOM 4558 CD2 TYR B 116 -3.215 40.131
36.486 1.00 0.44 C ATOM 4559 CE1 TYR B 116 -1.624 42.331 36.797
1.00 0.44 C ATOM 4560 CE2 TYR B 116 -1.851 40.007 36.391 1.00 0.44
C ATOM 4561 CZ TYR B 116 -1.050 41.109 36.548 1.00 0.44 C ATOM 4562
OH TYR B 116 0.352 40.983 36.451 1.00 0.44 O ATOM 4563 H TYR B 116
-4.340 40.999 34.057 1.00 0.00 H ATOM 4564 HA TYR B 116 -6.838
41.795 35.343 1.00 0.00 H ATOM 4565 1HB TYR B 116 -5.732 40.521
37.186 1.00 0.00 H ATOM 4566 2HB TYR B 116 -5.607 42.248 37.523
1.00 0.00 H ATOM 4567 HD1 TYR B 116 -3.439 43.399 37.135 1.00 0.00
H ATOM 4568 HD2 TYR B 116 -3.838 39.248 36.357 1.00 0.00 H ATOM
4569 HE1 TYR B 116 -0.986 43.139 37.108 1.00 0.00 H ATOM 4570 HE2
TYR B 116 -1.421 39.030 36.180 1.00 0.00 H ATOM 4571 HH TYR B 116
0.572 40.183 35.940 1.00 0.00 H ATOM 4572 N LYS B 117 -5.625 44.154
35.689 1.00 0.45 N ATOM 4573 CA LYS B 117 -5.196 45.486 35.366 1.00
0.45 C ATOM 4574 C LYS B 117 -5.361 45.714 33.903 1.00 0.45 C ATOM
4575 O LYS B 117 -4.381 45.874 33.177 1.00 0.45 O ATOM 4576 CB LYS
B 117 -3.732 45.803 35.716 1.00 0.45 C ATOM 4577 CG LYS B 117
-3.486 46.035 37.205 1.00 0.45 C ATOM 4578 CD LYS B 117 -2.021
46.314 37.540 1.00 0.45 C ATOM 4579 CE LYS B 117 -1.803 46.773
38.982 1.00 0.45 C ATOM 4580 NZ LYS B 117 -1.648 45.598 39.868 1.00
0.45 N1+ ATOM 4581 H LYS B 117 -6.473 44.044 36.231 1.00 0.00 H
ATOM 4582 HA LYS B 117 -5.857 46.181 35.904 1.00 0.00 H ATOM 4583
1HB LYS B 117 -3.423 46.732 35.202 1.00 0.00 H ATOM 4584 2HB LYS B
117 -3.072 45.012 35.321 1.00 0.00 H ATOM 4585 1HG LYS B 117 -4.032
45.396 37.906 1.00 0.00 H ATOM 4586 2HG LYS B 117 -3.730 47.063
37.280 1.00 0.00 H ATOM 4587 1HD LYS B 117 -1.662 47.096 36.845
1.00 0.00 H ATOM 4588 2HD LYS B 117 -1.404 45.426 37.399 1.00 0.00
H ATOM 4589 1HE LYS B 117 -2.615 47.410 39.361 1.00 0.00 H ATOM
4590 2HE LYS B 117 -0.875 47.361 39.082 1.00 0.00 H ATOM 4591 1HZ
LYS B 117 -1.543 45.856 40.843 1.00 0.00 H ATOM 4592 2HZ LYS B 117
-2.458 44.990 39.832 1.00 0.00 H ATOM 4593 3HZ LYS B 117 -0.847
45.024 39.642 1.00 0.00 H ATOM 4594 N VAL B 118 -6.621 45.732
33.433 1.00 0.21 N ATOM 4595 CA VAL B 118 -6.873 45.917 32.037 1.00
0.21 C ATOM 4596 C VAL B 118 -7.212 47.354 31.806 1.00 0.21 C ATOM
4597 O VAL B 118 -7.958 47.964 32.569 1.00 0.21 O ATOM 4598 CB VAL
B 118 -8.032 45.104 31.546 1.00 0.21 C ATOM 4599 CG1 VAL B 118
-8.313 45.486 30.088 1.00 0.21 C ATOM 4600 CG2 VAL B 118 -7.708
43.615 31.749 1.00 0.21 C ATOM 4601 H VAL B 118 -7.436 45.659
34.029 1.00 0.00 H ATOM 4602 HA VAL B 118 -5.985 45.589 31.488 1.00
0.00 H ATOM 4603 HB VAL B 118 -8.930 45.345 32.142 1.00 0.00 H ATOM
4604 1HG1 VAL B 118 -9.124 44.854 29.695 1.00 0.00 H ATOM 4605 2HG1
VAL B 118 -8.627 46.530 29.946 1.00 0.00 H ATOM 4606 3HG1 VAL B 118
-7.398 45.279 29.526 1.00 0.00 H ATOM 4607 1HG2 VAL B 118 -8.494
42.960 31.340 1.00 0.00 H ATOM 4608 2HG2 VAL B 118 -6.771 43.353
31.231 1.00 0.00 H ATOM 4609 3HG2 VAL B 118 -7.597 43.351 32.813
1.00 0.00 H ATOM 4610 N ILE B 119 -6.636 47.944 30.739 1.00 0.09 N
ATOM 4611 CA ILE B 119 -6.937 49.309 30.434 1.00 0.09 C ATOM 4612 C
ILE B 119 -7.363 49.370 29.005 1.00 0.09 C ATOM 4613 O ILE B 119
-6.814 48.678 28.149 1.00 0.09 O ATOM 4614 CB ILE B 119 -5.765
50.232 30.583 1.00 0.09 C ATOM 4615 CG1 ILE B 119 -5.244 50.204
32.028 1.00 0.09 C ATOM 4616 CG2 ILE B 119 -6.202 51.627 30.108
1.00 0.09 C ATOM 4617 CD1 ILE B 119 -3.887 50.886 32.199 1.00 0.09
C ATOM 4618 H ILE B 119 -5.959 47.463 30.152 1.00 0.00 H ATOM 4619
HA ILE B 119 -7.753 49.658 31.079 1.00 0.00 H ATOM 4620 HB ILE B
119 -4.971 49.878 29.921 1.00 0.00 H ATOM 4621 1HG1 ILE B 119
-5.125 49.169 32.385 1.00 0.00 H ATOM 4622 2HG1 ILE B 119 -5.963
50.777 32.619 1.00 0.00 H ATOM 4623 1HG2 ILE B 119 -5.476 52.407
30.381 1.00 0.00 H ATOM 4624 2HG2 ILE B 119 -6.341 51.692 29.021
1.00 0.00 H ATOM 4625 3HG2 ILE B 119 -7.135 51.938 30.599 1.00 0.00
H ATOM 4626 1HD1 ILE B 119 -3.575 50.833 33.256 1.00 0.00 H ATOM
4627 2HD1 ILE B 119 -3.103 50.373 31.623 1.00 0.00 H ATOM 4628 3HD1
ILE B 119 -3.918 51.955 31.943 1.00 0.00 H ATOM 4629 N TYR B 120
-8.383 50.200 28.722 1.00 0.09 N ATOM 4630 CA TYR B 120 -8.837
50.378 27.377 1.00 0.09 C ATOM 4631 C TYR B 120 -8.350 51.707
26.923 1.00 0.09 C ATOM 4632 O TYR B 120 -8.418 52.691 27.658 1.00
0.09 O ATOM 4633 CB TYR B 120 -10.367 50.372 27.212 1.00 0.09 C
ATOM 4634 CG TYR B 120 -10.850 48.963 27.189 1.00 0.09 C ATOM 4635
CD1 TYR B 120 -11.051 48.235 28.339 1.00 0.09 C ATOM 4636 CD2 TYR B
120 -11.111 48.374 25.973 1.00 0.09 C ATOM 4637 CE1 TYR B 120
-11.504 46.937 28.266 1.00 0.09 C ATOM 4638 CE2 TYR B 120 -11.563
47.081 25.893 1.00 0.09 C ATOM 4639 CZ TYR B 120 -11.761 46.361
27.043 1.00 0.09 C ATOM 4640 OH TYR B 120 -12.226 45.034 26.949
1.00 0.09 O ATOM 4641 H TYR B 120 -8.759 50.823 29.425 1.00 0.00 H
ATOM 4642 HA TYR B 120 -8.416 49.584 26.738 1.00 0.00 H ATOM 4643
1HB TYR B 120 -10.609 50.876 26.261 1.00 0.00 H ATOM 4644 2HB TYR B
120 -10.841 50.971 28.003
1.00 0.00 H ATOM 4645 HD1 TYR B 120 -10.803 48.686 29.294 1.00 0.00
H ATOM 4646 HD2 TYR B 120 -10.958 48.938 25.055 1.00 0.00 H ATOM
4647 HE1 TYR B 120 -11.634 46.356 29.175 1.00 0.00 H ATOM 4648 HE2
TYR B 120 -11.814 46.651 24.941 1.00 0.00 H ATOM 4649 HH TYR B 120
-11.973 44.595 27.775 1.00 0.00 H ATOM 4650 N TYR B 121 -7.816
51.760 25.689 1.00 0.18 N ATOM 4651 CA TYR B 121 -7.302 52.999
25.199 1.00 0.18 C ATOM 4652 C TYR B 121 -8.013 53.324 23.925 1.00
0.18 C ATOM 4653 O TYR B 121 -8.291 52.449 23.108 1.00 0.18 O ATOM
4654 CB TYR B 121 -5.803 52.937 24.877 1.00 0.18 C ATOM 4655 CG TYR
B 121 -5.083 52.647 26.150 1.00 0.18 C ATOM 4656 CD1 TYR B 121
-4.694 53.668 26.987 1.00 0.18 C ATOM 4657 CD2 TYR B 121 -4.800
51.349 26.509 1.00 0.18 C ATOM 4658 CE1 TYR B 121 -4.028 53.397
28.160 1.00 0.18 C ATOM 4659 CE2 TYR B 121 -4.134 51.074 27.679
1.00 0.18 C ATOM 4660 CZ TYR B 121 -3.744 52.098 28.506 1.00 0.18 C
ATOM 4661 OH TYR B 121 -3.059 51.815 29.707 1.00 0.18 O ATOM 4662 H
TYR B 121 -7.619 50.943 25.120 1.00 0.00 H ATOM 4663 HA TYR B 121
-7.431 53.759 25.960 1.00 0.00 H ATOM 4664 1HB TYR B 121 -5.500
53.911 24.460 1.00 0.00 H ATOM 4665 2HB TYR B 121 -5.589 52.184
24.103 1.00 0.00 H ATOM 4666 HD1 TYR B 121 -4.883 54.701 26.707
1.00 0.00 H ATOM 4667 HD2 TYR B 121 -5.074 50.534 25.848 1.00 0.00
H ATOM 4668 HE1 TYR B 121 -3.684 54.220 28.783 1.00 0.00 H ATOM
4669 HE2 TYR B 121 -4.040 50.026 27.774 1.00 0.00 H ATOM 4670 HH
TYR B 121 -2.245 52.351 29.616 1.00 0.00 H ATOM 4671 N LYS B 122
-8.347 54.617 23.757 1.00 0.28 N ATOM 4672 CA LYS B 122 -9.000
55.139 22.598 1.00 0.28 C ATOM 4673 C LYS B 122 -8.109 56.236
22.126 1.00 0.28 C ATOM 4674 O LYS B 122 -7.986 57.264 22.790 1.00
0.28 O ATOM 4675 CB LYS B 122 -10.349 55.804 22.933 1.00 0.28 C
ATOM 4676 CG LYS B 122 -11.176 56.243 21.722 1.00 0.28 C ATOM 4677
CD LYS B 122 -12.535 56.836 22.111 1.00 0.28 C ATOM 4678 CE LYS B
122 -13.183 56.151 23.316 1.00 0.28 C ATOM 4679 NZ LYS B 122
-14.483 56.791 23.628 1.00 0.28 N1+ ATOM 4680 H LYS B 122 -8.144
55.299 24.484 1.00 0.00 H ATOM 4681 HA LYS B 122 -9.164 54.338
21.865 1.00 0.00 H ATOM 4682 1HB LYS B 122 -10.242 56.625 23.659
1.00 0.00 H ATOM 4683 2HB LYS B 122 -10.988 55.031 23.342 1.00 0.00
H ATOM 4684 1HG LYS B 122 -11.311 55.374 21.057 1.00 0.00 H ATOM
4685 2HG LYS B 122 -10.623 56.984 21.114 1.00 0.00 H ATOM 4686 1HD
LYS B 122 -13.201 56.854 21.232 1.00 0.00 H ATOM 4687 2HD LYS B 122
-12.369 57.894 22.385 1.00 0.00 H ATOM 4688 1HE LYS B 122 -12.551
56.319 24.190 1.00 0.00 H ATOM 4689 2HE LYS B 122 -13.425 55.120
23.185 1.00 0.00 H ATOM 4690 1HZ LYS B 122 -14.924 56.393 24.445
1.00 0.00 H ATOM 4691 2HZ LYS B 122 -14.393 57.785 23.789 1.00 0.00
H ATOM 4692 3HZ LYS B 122 -15.134 56.665 22.860 1.00 0.00 H ATOM
4693 N ASP B 123 -7.464 56.040 20.965 1.00 0.20 N ATOM 4694 CA ASP
B 123 -6.591 57.040 20.428 1.00 0.20 C ATOM 4695 C ASP B 123 -5.595
57.437 21.470 1.00 0.20 C ATOM 4696 O ASP B 123 -5.193 58.597
21.556 1.00 0.20 O ATOM 4697 CB ASP B 123 -7.339 58.273 19.901 1.00
0.20 C ATOM 4698 CG ASP B 123 -8.044 57.821 18.631 1.00 0.20 C ATOM
4699 OD1 ASP B 123 -7.553 56.845 18.001 1.00 0.20 O ATOM 4700 OD2
ASP B 123 -9.081 58.436 18.274 1.00 0.20 O1- ATOM 4701 H ASP B 123
-7.659 55.230 20.379 1.00 0.00 H ATOM 4702 HA ASP B 123 -5.967
56.577 19.640 1.00 0.00 H ATOM 4703 1HB ASP B 123 -6.613 59.051
19.613 1.00 0.00 H ATOM 4704 2HB ASP B 123 -8.032 58.726 20.624
1.00 0.00 H ATOM 4705 N GLY B 124 -5.173 56.462 22.296 1.00 0.17 N
ATOM 4706 CA GLY B 124 -4.147 56.707 23.266 1.00 0.17 C ATOM 4707 C
GLY B 124 -4.739 57.254 24.523 1.00 0.17 C ATOM 4708 O GLY B 124
-4.011 57.600 25.454 1.00 0.17 O ATOM 4709 H GLY B 124 -5.500
55.518 22.162 1.00 0.00 H ATOM 4710 1HA GLY B 124 -3.397 57.414
22.878 1.00 0.00 H ATOM 4711 2HA GLY B 124 -3.641 55.758 23.511
1.00 0.00 H ATOM 4712 N GLU B 125 -6.076 57.350 24.601 1.00 0.24 N
ATOM 4713 CA GLU B 125 -6.638 57.879 25.806 1.00 0.24 C ATOM 4714 C
GLU B 125 -7.229 56.729 26.552 1.00 0.24 C ATOM 4715 O GLU B 125
-7.934 55.904 25.980 1.00 0.24 O ATOM 4716 CB GLU B 125 -7.747
58.908 25.550 1.00 0.24 C ATOM 4717 CG GLU B 125 -8.099 59.729
26.785 1.00 0.24 C ATOM 4718 CD GLU B 125 -9.183 60.720 26.392 1.00
0.24 C ATOM 4719 OE1 GLU B 125 -10.013 60.366 25.512 1.00 0.24 O
ATOM 4720 OE2 GLU B 125 -9.192 61.843 26.962 1.00 0.24 O1- ATOM
4721 H GLU B 125 -6.663 57.298 23.773 1.00 0.00 H ATOM 4722 HA GLU
B 125 -5.870 58.399 26.400 1.00 0.00 H ATOM 4723 1HB GLU B 125
-8.638 58.390 25.156 1.00 0.00 H ATOM 4724 2HB GLU B 125 -7.408
59.599 24.755 1.00 0.00 H ATOM 4725 1HG GLU B 125 -7.225 60.253
27.203 1.00 0.00 H ATOM 4726 2HG GLU B 125 -8.494 59.077 27.582
1.00 0.00 H ATOM 4727 N ALA B 126 -6.967 56.629 27.865 1.00 0.26 N
ATOM 4728 CA ALA B 126 -7.483 55.489 28.563 1.00 0.26 C ATOM 4729 C
ALA B 126 -8.923 55.737 28.870 1.00 0.26 C ATOM 4730 O ALA B 126
-9.257 56.616 29.662 1.00 0.26 O ATOM 4731 CB ALA B 126 -6.771
55.212 29.898 1.00 0.26 C ATOM 4732 H ALA B 126 -6.347 57.258
28.348 1.00 0.00 H ATOM 4733 HA ALA B 126 -7.283 54.612 27.943 1.00
0.00 H ATOM 4734 1HB ALA B 126 -7.245 54.340 30.375 1.00 0.00 H
ATOM 4735 2HB ALA B 126 -5.708 54.984 29.733 1.00 0.00 H ATOM 4736
3HB ALA B 126 -6.835 56.063 30.593 1.00 0.00 H ATOM 4737 N LEU B
127 -9.819 54.977 28.210 1.00 0.39 N ATOM 4738 CA LEU B 127 -11.223
55.120 28.455 1.00 0.39 C ATOM 4739 C LEU B 127 -11.504 54.659
29.846 1.00 0.39 C ATOM 4740 O LEU B 127 -12.150 55.361 30.622 1.00
0.39 O ATOM 4741 CB LEU B 127 -12.082 54.243 27.532 1.00 0.39 C
ATOM 4742 CG LEU B 127 -11.973 54.616 26.046 1.00 0.39 C ATOM 4743
CD1 LEU B 127 -10.541 54.413 25.527 1.00 0.39 C ATOM 4744 CD2 LEU B
127 -13.021 53.865 25.210 1.00 0.39 C ATOM 4745 H LEU B 127 -9.482
54.256 27.585 1.00 0.00 H ATOM 4746 HA LEU B 127 -11.515 56.177
28.359 1.00 0.00 H ATOM 4747 1HB LEU B 127 -13.130 54.364 27.866
1.00 0.00 H ATOM 4748 2HB LEU B 127 -11.833 53.177 27.665 1.00 0.00
H ATOM 4749 HG LEU B 127 -12.194 55.696 26.007 1.00 0.00 H ATOM
4750 1HD1 LEU B 127 -10.536 53.792 24.623 1.00 0.00 H ATOM 4751
2HD1 LEU B 127 -10.073 55.385 25.396 1.00 0.00 H ATOM 4752 3HD1 LEU
B 127 -9.942 53.772 26.170 1.00 0.00 H ATOM 4753 1HD2 LEU B 127
-12.582 54.000 24.252 1.00 0.00 H ATOM 4754 2HD2 LEU B 127 -13.035
52.790 25.442 1.00 0.00 H ATOM 4755 3HD2 LEU B 127 -14.037 54.274
25.281 1.00 0.00 H ATOM 4756 N LYS B 128 -11.008 53.457 30.209 1.00
0.43 N ATOM 4757 CA LYS B 128 -11.294 52.985 31.530 1.00 0.43 C
ATOM 4758 C LYS B 128 -10.216 52.042 31.948 1.00 0.43 C ATOM 4759 O
LYS B 128 -9.524 51.449 31.122 1.00 0.43 O ATOM 4760 CB LYS B 128
-12.614 52.207 31.641 1.00 0.43 C ATOM 4761 CG LYS B 128 -12.560
50.838 30.960 1.00 0.43 C ATOM 4762 CD LYS B 128 -13.718 49.918
31.350 1.00 0.43 C ATOM 4763 CE LYS B 128 -13.540 48.478 30.872
1.00 0.43 C ATOM 4764 NZ LYS B 128 -12.447 47.835 31.635 1.00 0.43
N1+ ATOM 4765 H LYS B 128 -10.327 52.978 29.647 1.00 0.00 H ATOM
4766 HA LYS B 128 -11.296 53.843 32.227 1.00 0.00 H ATOM 4767 1HB
LYS B 128 -13.445 52.810 31.235 1.00 0.00 H ATOM 4768 2HB LYS B 128
-12.825 52.073 32.717 1.00 0.00 H ATOM 4769 1HG LYS B 128 -11.647
50.306 31.271 1.00 0.00 H ATOM 4770 2HG LYS B 128 -12.473 50.978
29.880 1.00 0.00 H ATOM 4771 1HD LYS B 128 -14.667 50.313 30.950
1.00 0.00 H ATOM 4772 2HD LYS B 128 -13.841 49.922 32.449 1.00 0.00
H ATOM 4773 1HE LYS B 128 -13.239 48.443 29.841 1.00 0.00 H ATOM
4774 2HE LYS B 128 -14.468 47.942 31.072 1.00 0.00 H ATOM 4775 1HZ
LYS B 128 -12.368 46.844 31.429 1.00 0.00 H ATOM 4776 2HZ LYS B 128
-11.541 48.241 31.441 1.00 0.00 H ATOM 4777 3HZ LYS B 128 -12.592
47.889 32.634 1.00 0.00 H ATOM 4778 N TYR B 129 -10.043 51.906
33.275 1.00 0.26 N ATOM 4779 CA TYR B 129 -9.095 50.989 33.832 1.00
0.26 C ATOM 4780 C TYR B 129 -9.784 50.262 34.940 1.00 0.26 C ATOM
4781 O TYR B 129 -10.405 50.879 35.803 1.00 0.26 O ATOM 4782 CB TYR
B 129 -7.861 51.683 34.435 1.00 0.26 C ATOM 4783 CG TYR B 129
-7.171 50.706 35.325 1.00 0.26 C ATOM 4784 CD1 TYR B 129 -6.375
49.701 34.823 1.00 0.26 C ATOM 4785 CD2 TYR B 129 -7.327 50.815
36.687 1.00 0.26 C ATOM 4786 CE1 TYR B 129 -5.750 48.816 35.674
1.00 0.26 C ATOM 4787 CE2 TYR B 129 -6.707 49.936 37.540 1.00 0.26
C ATOM 4788 CZ TYR B 129 -5.916 48.935 37.035 1.00 0.26 C ATOM 4789
OH TYR B 129 -5.283 48.036 37.916 1.00 0.26 O ATOM 4790 H TYR B 129
-10.607 52.393 33.952 1.00 0.00 H ATOM 4791 HA TYR B 129 -8.771
50.291 33.049 1.00 0.00 H ATOM 4792 1HB TYR B 129 -8.174 52.568
35.013 1.00 0.00 H ATOM 4793 2HB TYR B 129 -7.213 52.072 33.637
1.00 0.00 H ATOM 4794 HD1 TYR B 129 -6.453 49.410 33.799 1.00 0.00
H ATOM 4795 HD2 TYR B 129 -7.952 51.605 37.097 1.00 0.00 H ATOM
4796 HE1 TYR B 129 -5.114 48.061 35.238 1.00 0.00 H ATOM 4797 HE2
TYR B 129 -6.841 50.075 38.607 1.00 0.00 H ATOM 4798 HH TYR B 129
-5.832 47.984 38.711 1.00 0.00 H ATOM 4799 N TRP B 130 -9.712
48.916 34.931 1.00 0.16 N ATOM 4800 CA TRP B 130 -10.311 48.181
36.006 1.00 0.16 C ATOM 4801 C TRP B 130 -9.437 46.987 36.219 1.00
0.16 C ATOM 4802 O TRP B 130 -8.929 46.405 35.261 1.00 0.16 O ATOM
4803 CB TRP B 130 -11.716 47.655 35.683 1.00 0.16 C ATOM 4804 CG
TRP B 130 -12.467 47.127 36.882 1.00 0.16 C ATOM 4805 CD1 TRP B 130
-12.409 45.906 37.486 1.00 0.16 C ATOM 4806 CD2 TRP B 130 -13.463
47.882 37.588 1.00 0.16 C ATOM 4807 NE1 TRP B 130 -13.299 45.859
38.532 1.00 0.16 N ATOM 4808 CE2 TRP B 130 -13.957 47.066 38.603
1.00 0.16 C ATOM 4809 CE3 TRP B 130 -13.932 49.151 37.402 1.00 0.16
C ATOM 4810 CZ2 TRP B 130 -14.932 47.506 39.452 1.00 0.16 C ATOM
4811 CZ3 TRP B 130 -14.913 49.593 38.264 1.00 0.16 C ATOM 4812 CH2
TRP B 130 -15.404 48.787 39.270 1.00 0.16 C ATOM 4813 H TRP B 130
-9.108 48.407 34.292 1.00 0.00 H ATOM 4814 HA TRP B 130 -10.329
48.805 36.916 1.00 0.00 H ATOM 4815 1HB TRP B 130 -11.622 46.878
34.909 1.00 0.00 H ATOM 4816 2HB TRP B 130 -12.306 48.463 35.220
1.00 0.00 H ATOM 4817 HD1 TRP B 130 -11.644 45.253 37.343 1.00 0.00
H ATOM 4818 HE1 TRP B 130 -13.577 45.048 39.057 1.00 0.00 H ATOM
4819 HE3 TRP B 130 -13.550 49.803 36.623 1.00 0.00 H ATOM 4820 HZ2
TRP B 130 -15.318 46.865 40.242 1.00 0.00 H ATOM 4821 HZ3 TRP B 130
-15.309 50.600 38.152 1.00 0.00 H ATOM 4822 HH2 TRP B 130 -16.179
49.170 39.930 1.00 0.00 H ATOM 4823 N TYR B 131 -9.204 46.599
37.487 1.00 0.17 N ATOM 4824 CA TYR B 131 -8.351 45.465 37.683 1.00
0.17 C ATOM 4825 C TYR B 131 -8.991 44.235 37.120 1.00 0.17 C ATOM
4826 O TYR B 131 -8.436 43.582 36.238 1.00 0.17 O ATOM 4827 CB TYR
B 131 -8.087 45.152 39.164 1.00 0.17 C ATOM 4828 CG TYR B 131
-7.166 46.173 39.731 1.00 0.17 C ATOM 4829 CD1 TYR B 131 -7.617
47.428 40.072 1.00 0.17 C ATOM 4830 CD2 TYR B 131 -5.844 45.857
39.937 1.00 0.17 C ATOM 4831 CE1 TYR B 131 -6.754 48.358 40.602
1.00 0.17 C ATOM 4832 CE2 TYR B 131 -4.977 46.782 40.465 1.00 0.17
C ATOM 4833 CZ TYR B 131 -5.433 48.034 40.800 1.00 0.17 C ATOM 4834
OH TYR B 131 -4.542 48.984 41.345 1.00 0.17 O ATOM 4835 H TYR B 131
-9.633 47.043 38.280 1.00 0.00 H ATOM 4836 HA TYR B 131 -7.395
45.633 37.177 1.00 0.00 H ATOM 4837 1HB TYR B 131 -7.635 44.147
39.216 1.00 0.00 H ATOM 4838 2HB TYR B 131 -9.022 45.099 39.746
1.00 0.00 H ATOM 4839 HD1 TYR B 131 -8.667 47.686 39.973 1.00 0.00
H ATOM 4840 HD2 TYR B 131 -5.494 44.854 39.704 1.00 0.00 H ATOM
4841 HE1 TYR B 131 -7.138 49.337 40.884 1.00 0.00 H ATOM 4842 HE2
TYR B 131 -3.963 46.496 40.710 1.00 0.00 H ATOM 4843 HH TYR B 131
-5.050 49.530 41.957 1.00 0.00 H ATOM 4844 N GLU B 132 -10.189
43.889 37.630 1.00 0.19 N ATOM 4845 CA GLU B 132 -10.842 42.670
37.249 1.00 0.19 C ATOM 4846 C GLU B 132 -11.520 42.727 35.909 1.00
0.19 C ATOM 4847 O GLU B 132 -11.501 41.741 35.175 1.00 0.19 O ATOM
4848 CB GLU B 132 -11.851 42.161 38.295 1.00 0.19 C ATOM 4849 CG
GLU B 132 -13.030 43.092 38.565 1.00 0.19 C ATOM 4850 CD GLU B 132
-13.838 42.479 39.702 1.00 0.19 C ATOM 4851 OE1 GLU B 132 -14.098
41.248 39.651 1.00 0.19 O ATOM 4852 OE2 GLU B 132 -14.202 43.236
40.641 1.00 0.19 O1- ATOM 4853 H GLU B 132 -10.574 44.356 38.433
1.00 0.00 H ATOM 4854 HA GLU B 132 -10.066 41.891 37.149 1.00 0.00
H ATOM 4855 1HB GLU B 132 -11.321 41.965 39.245 1.00 0.00 H ATOM
4856 2HB GLU B 132 -12.189 41.177 37.919 1.00 0.00 H ATOM 4857 1HG
GLU B 132 -13.639 43.344 37.692 1.00 0.00 H ATOM 4858 2HG GLU B 132
-12.498 43.899 39.059 1.00 0.00 H ATOM 4859 N ASN B 133 -12.116
43.878 35.539 1.00 0.18 N ATOM 4860 CA ASN B 133 -12.974 43.903
34.382 1.00 0.18 C ATOM 4861 C ASN B 133 -12.209 43.857 33.098 1.00
0.18 C ATOM 4862 O ASN B 133 -11.487 44.786 32.738 1.00 0.18 O ATOM
4863 CB ASN B 133 -13.907 45.129 34.320 1.00 0.18 C ATOM 4864 CG
ASN B 133 -14.988 44.843 33.284 1.00 0.18 C ATOM 4865 OD1 ASN B 133
-14.893 43.882 32.522 1.00 0.18 O ATOM 4866 ND2 ASN B 133 -16.041
45.704 33.248 1.00 0.18 N ATOM 4867 H ASN B 133 -12.148 44.684
36.122 1.00 0.00 H ATOM 4868 HA ASN B 133 -13.641 43.023 34.482
1.00 0.00 H ATOM 4869 1HB ASN B 133 -13.387 46.056 34.048 1.00 0.00
H ATOM 4870 2HB ASN B 133 -14.388 45.278 35.302 1.00 0.00 H ATOM
4871 1HD2 ASN B 133 -16.148 46.456 33.904 1.00 0.00 H ATOM 4872
2HD2 ASN B 133 -16.734 45.541 32.536 1.00 0.00 H ATOM 4873 N HIS B
134 -12.358 42.718 32.393 1.00 0.16 N ATOM 4874 CA HIS B 134
-11.782 42.426 31.111 1.00 0.16 C ATOM 4875 C HIS B 134 -12.510
43.153 30.020 1.00 0.16 C ATOM 4876 O HIS B 134 -11.908 43.530
29.016 1.00 0.16 O ATOM 4877 CB HIS B 134 -11.845 40.927 30.781
1.00 0.16 C ATOM 4878 CG HIS B 134 -11.133 40.093 31.803 1.00 0.16
C ATOM 4879 ND1 HIS B 134 -9.767 39.912 31.837 1.00 0.16 N ATOM
4880 CD2 HIS B 134 -11.627 39.390 32.858 1.00 0.16 C ATOM 4881 CE1
HIS B 134 -9.506 39.115 32.903 1.00 0.16 C ATOM 4882 NE2 HIS B 134
-10.603 38.772 33.554 1.00 0.16 N ATOM 4883 H HIS B 134 -12.816
41.946 32.852 1.00 0.00 H ATOM 4884 HA HIS B 134 -10.736 42.768
31.094 1.00 0.00 H ATOM 4885 1HB HIS B 134 -11.406 40.786 29.778
1.00 0.00 H ATOM 4886 2HB HIS B 134 -12.890 40.590 30.715 1.00 0.00
H ATOM 4887 HD2 HIS B 134 -12.657 39.288 33.175 1.00 0.00 H ATOM
4888 HE1 HIS B 134 -8.543 38.682 33.088 1.00 0.00 H ATOM 4889 HE2
HIS B 134 -10.667 38.227 34.389 1.00 0.00 H ATOM 4890 N ASN B 135
-13.835 43.359 30.179 1.00 0.14 N ATOM 4891 CA ASN B 135 -14.631
43.884 29.100 1.00 0.14 C ATOM 4892 C ASN B 135 -14.941 45.332
29.306 1.00 0.14 C ATOM 4893 O ASN B 135 -14.867 45.856 30.416 1.00
0.14 O ATOM 4894 CB ASN B 135 -15.986 43.176 28.963 1.00 0.14 C
ATOM 4895 CG ASN B 135 -15.720 41.710 28.665 1.00 0.14 C ATOM 4896
OD1 ASN B 135 -15.032 41.368 27.704 1.00 0.14 O ATOM 4897 ND2 ASN B
135 -16.270 40.813 29.528 1.00 0.14 N ATOM 4898 H ASN B 135 -14.277
43.286 31.091 1.00 0.00 H ATOM 4899 HA ASN B 135 -14.091 43.740
28.156 1.00 0.00 H ATOM 4900 1HB ASN B 135 -16.465 43.667 28.112
1.00 0.00 H ATOM 4901 2HB ASN B 135 -16.609 43.336 29.857 1.00 0.00
H ATOM 4902 1HD2 ASN B 135 -16.809 41.103 30.323 1.00 0.00 H ATOM
4903 2HD2 ASN B 135 -16.088 39.839 29.364 1.00 0.00 H ATOM 4904 N
ILE B 136 -15.270 46.020 28.190 1.00 0.19 N ATOM 4905 CA ILE B 136
-15.665 47.399 28.207 1.00 0.19 C ATOM 4906 C ILE B 136 -16.831
47.525 27.279 1.00 0.19 C ATOM 4907 O ILE B 136 -16.909 46.824
26.272 1.00 0.19 O ATOM 4908 CB ILE B 136 -14.612 48.337 27.694
1.00 0.19 C ATOM 4909 CG1 ILE B 136 -15.014 49.796 27.966 1.00 0.19
C ATOM 4910 CG2 ILE B 136 -14.381 48.022 26.207 1.00 0.19 C ATOM
4911 CD1 ILE B 136 -13.874 50.789 27.751 1.00 0.19 C ATOM 4912 H
ILE B 136 -15.313 45.559 27.283 1.00 0.00 H ATOM 4913 HA ILE B 136
-15.976 47.652 29.234 1.00 0.00 H ATOM 4914 HB ILE B 136 -13.653
48.104 28.141 1.00 0.00 H ATOM 4915 1HG1 ILE B 136 -15.391 49.896
28.996 1.00 0.00 H ATOM 4916 2HG1 ILE B 136 -15.848 50.096 27.307
1.00 0.00 H ATOM 4917 1HG2 ILE B 136 -13.544 48.610 25.812 1.00
0.00 H ATOM 4918 2HG2 ILE B 136 -14.172 46.948 26.193 1.00 0.00 H
ATOM 4919 3HG2 ILE B 136 -15.231 48.283 25.560 1.00 0.00 H ATOM
4920 1HD1 ILE B 136 -14.060 51.752 28.250 1.00 0.00 H ATOM 4921
2HD1 ILE B 136 -12.927 50.375 28.101 1.00 0.00 H ATOM 4922 3HD1 ILE
B 136 -13.745 50.990 26.675 1.00 0.00 H ATOM 4923 N SER B 137
-17.788 48.414 27.604 1.00 0.24 N ATOM 4924 CA SER B 137 -18.920
48.568 26.741 1.00 0.24 C ATOM 4925 C SER B 137 -19.203 50.029
26.610 1.00 0.24 C ATOM 4926 O SER B 137 -19.102
50.781 27.577 1.00 0.24 O ATOM 4927 CB SER B 137 -20.185 47.894
27.299 1.00 0.24 C ATOM 4928 OG SER B 137 -21.276 48.071 26.411
1.00 0.24 O ATOM 4929 H SER B 137 -17.726 49.066 28.368 1.00 0.00 H
ATOM 4930 HA SER B 137 -18.674 48.121 25.782 1.00 0.00 H ATOM 4931
1HB SER B 137 -20.436 48.283 28.302 1.00 0.00 H ATOM 4932 2HB SER B
137 -20.027 46.813 27.395 1.00 0.00 H ATOM 4933 HG SER B 137
-21.483 49.017 26.401 1.00 0.00 H ATOM 4934 N ILE B 138 -19.553
50.475 25.389 1.00 0.31 N ATOM 4935 CA ILE B 138 -19.872 51.857
25.203 1.00 0.31 C ATOM 4936 C ILE B 138 -21.299 51.893 24.779 1.00
0.31 C ATOM 4937 O ILE B 138 -21.688 51.253 23.804 1.00 0.31 O ATOM
4938 CB ILE B 138 -19.075 52.508 24.114 1.00 0.31 C ATOM 4939 CG1
ILE B 138 -17.571 52.405 24.424 1.00 0.31 C ATOM 4940 CG2 ILE B 138
-19.578 53.954 23.962 1.00 0.31 C ATOM 4941 CD1 ILE B 138 -16.674
52.719 23.229 1.00 0.31 C ATOM 4942 H ILE B 138 -19.600 49.853
24.587 1.00 0.00 H ATOM 4943 HA ILE B 138 -19.710 52.421 26.135
1.00 0.00 H ATOM 4944 HB ILE B 138 -19.268 52.008 23.155 1.00 0.00
H ATOM 4945 1HG1 ILE B 138 -17.316 51.376 24.735 1.00 0.00 H ATOM
4946 2HG1 ILE B 138 -17.308 53.049 25.281 1.00 0.00 H ATOM 4947
1HG2 ILE B 138 -18.854 54.629 23.492 1.00 0.00 H ATOM 4948 2HG2 ILE
B 138 -20.505 54.001 23.368 1.00 0.00 H ATOM 4949 3HG2 ILE B 138
-19.788 54.411 24.944 1.00 0.00 H ATOM 4950 1HD1 ILE B 138 -15.696
52.223 23.340 1.00 0.00 H ATOM 4951 2HD1 ILE B 138 -17.111 52.364
22.288 1.00 0.00 H ATOM 4952 3HD1 ILE B 138 -16.455 53.793 23.163
1.00 0.00 H ATOM 4953 N THR B 139 -22.134 52.652 25.502 1.00 0.40 N
ATOM 4954 CA THR B 139 -23.515 52.679 25.136 1.00 0.40 C ATOM 4955
C THR B 139 -23.749 53.927 24.359 1.00 0.40 C ATOM 4956 O THR B 139
-23.036 54.914 24.535 1.00 0.40 O ATOM 4957 CB THR B 139 -24.443
52.677 26.311 1.00 0.40 C ATOM 4958 OG1 THR B 139 -24.163 53.789
27.147 1.00 0.40 O ATOM 4959 CG2 THR B 139 -24.261 51.362 27.085
1.00 0.40 C ATOM 4960 H THR B 139 -21.877 53.234 26.282 1.00 0.00 H
ATOM 4961 HA THR B 139 -23.767 51.798 24.523 1.00 0.00 H ATOM 4962
HB THR B 139 -25.487 52.734 25.945 1.00 0.00 H ATOM 4963 HG1 THR B
139 -24.403 54.588 26.652 1.00 0.00 H ATOM 4964 1HG2 THR B 139
-24.978 51.292 27.920 1.00 0.00 H ATOM 4965 2HG2 THR B 139 -24.420
50.485 26.436 1.00 0.00 H ATOM 4966 3HG2 THR B 139 -23.251 51.293
27.520 1.00 0.00 H ATOM 4967 N ASN B 140 -24.763 53.894 23.470 1.00
0.29 N ATOM 4968 CA ASN B 140 -25.086 55.022 22.647 1.00 0.29 C
ATOM 4969 C ASN B 140 -23.840 55.522 21.994 1.00 0.29 C ATOM 4970 O
ASN B 140 -23.385 56.631 22.272 1.00 0.29 O ATOM 4971 CB ASN B 140
-25.727 56.185 23.423 1.00 0.29 C ATOM 4972 CG ASN B 140 -27.131
55.764 23.832 1.00 0.29 C ATOM 4973 OD1 ASN B 140 -27.317 54.884
24.671 1.00 0.29 O ATOM 4974 ND2 ASN B 140 -28.154 56.419 23.222
1.00 0.29 N ATOM 4975 H ASN B 140 -25.351 53.083 23.363 1.00 0.00 H
ATOM 4976 HA ASN B 140 -25.796 54.687 21.874 1.00 0.00 H ATOM 4977
1HB ASN B 140 -25.766 57.075 22.770 1.00 0.00 H ATOM 4978 2HB ASN B
140 -25.173 56.460 24.334 1.00 0.00 H ATOM 4979 1HD2 ASN B 140
-27.995 57.144 22.547 1.00 0.00 H ATOM 4980 2HD2 ASN B 140 -29.087
56.156 23.487 1.00 0.00 H ATOM 4981 N ALA B 141 -23.250 54.699
21.107 1.00 0.26 N ATOM 4982 CA ALA B 141 -22.029 55.068 20.453
1.00 0.26 C ATOM 4983 C ALA B 141 -22.269 56.305 19.652 1.00 0.26 C
ATOM 4984 O ALA B 141 -23.383 56.573 19.206 1.00 0.26 O ATOM 4985
CB ALA B 141 -21.490 53.988 19.499 1.00 0.26 C ATOM 4986 H ALA B
141 -23.587 53.762 20.926 1.00 0.00 H ATOM 4987 HA ALA B 141
-21.258 55.258 21.225 1.00 0.00 H ATOM 4988 1HB ALA B 141 -20.549
54.340 19.046 1.00 0.00 H ATOM 4989 2HB ALA B 141 -21.267 53.060
20.048 1.00 0.00 H ATOM 4990 3HB ALA B 141 -22.201 53.762 18.690
1.00 0.00 H ATOM 4991 N THR B 142 -21.198 57.103 19.475 1.00 0.35 N
ATOM 4992 CA THR B 142 -21.277 58.331 18.746 1.00 0.35 C ATOM 4993
C THR B 142 -20.122 58.368 17.797 1.00 0.35 C ATOM 4994 O THR B 142
-19.288 57.465 17.779 1.00 0.35 O ATOM 4995 CB THR B 142 -21.175
59.547 19.617 1.00 0.35 C ATOM 4996 OG1 THR B 142 -21.424 60.721
18.859 1.00 0.35 O ATOM 4997 CG2 THR B 142 -19.764 59.596 20.230
1.00 0.35 C ATOM 4998 H THR B 142 -20.268 56.794 19.709 1.00 0.00 H
ATOM 4999 HA THR B 142 -22.202 58.374 18.164 1.00 0.00 H ATOM 5000
HB THR B 142 -21.924 59.484 20.430 1.00 0.00 H ATOM 5001 HG1 THR B
142 -20.924 61.441 19.314 1.00 0.00 H ATOM 5002 1HG2 THR B 142
-19.677 60.411 20.966 1.00 0.00 H ATOM 5003 2HG2 THR B 142 -19.545
58.677 20.799 1.00 0.00 H ATOM 5004 3HG2 THR B 142 -19.002 59.711
19.495 1.00 0.00 H ATOM 5005 N VAL B 143 -20.067 59.427 16.968 1.00
0.29 N ATOM 5006 CA VAL B 143 -19.038 59.595 15.985 1.00 0.29 C
ATOM 5007 C VAL B 143 -17.723 59.745 16.680 1.00 0.29 C ATOM 5008 O
VAL B 143 -16.696 59.265 16.203 1.00 0.29 O ATOM 5009 CB VAL B 143
-19.256 60.803 15.127 1.00 0.29 C ATOM 5010 CG1 VAL B 143 -18.096
60.900 14.122 1.00 0.29 C ATOM 5011 CG2 VAL B 143 -20.644 60.686
14.470 1.00 0.29 C ATOM 5012 H VAL B 143 -20.761 60.162 17.079 1.00
0.00 H ATOM 5013 HA VAL B 143 -18.850 58.830 15.329 1.00 0.00 H
ATOM 5014 HB VAL B 143 -19.249 61.727 15.730 1.00 0.00 H ATOM 5015
1HG1 VAL B 143 -18.282 61.693 13.377 1.00 0.00 H ATOM 5016 2HG1 VAL
B 143 -17.142 61.156 14.609 1.00 0.00 H ATOM 5017 3HG1 VAL B 143
-17.963 59.961 13.559 1.00 0.00 H ATOM 5018 1HG2 VAL B 143 -20.742
61.326 13.578 1.00 0.00 H ATOM 5019 2HG2 VAL B 143 -20.859 59.656
14.167 1.00 0.00 H ATOM 5020 3HG2 VAL B 143 -21.447 60.987 15.163
1.00 0.00 H ATOM 5021 N GLU B 144 -17.728 60.414 17.845 1.00 0.25 N
ATOM 5022 CA GLU B 144 -16.522 60.650 18.585 1.00 0.25 C ATOM 5023
C GLU B 144 -15.953 59.324 18.969 1.00 0.25 C ATOM 5024 O GLU B 144
-14.738 59.159 19.072 1.00 0.25 O ATOM 5025 CB GLU B 144 -16.760
61.452 19.874 1.00 0.25 C ATOM 5026 CG GLU B 144 -17.200 62.889
19.597 1.00 0.25 C ATOM 5027 CD GLU B 144 -18.626 62.836 19.072
1.00 0.25 C ATOM 5028 OE1 GLU B 144 -19.542 62.548 19.886 1.00 0.25
O ATOM 5029 OE2 GLU B 144 -18.817 63.075 17.849 1.00 0.25 O1- ATOM
5030 H GLU B 144 -18.487 61.065 18.039 1.00 0.00 H ATOM 5031 HA GLU
B 144 -15.773 61.169 17.962 1.00 0.00 H ATOM 5032 1HB GLU B 144
-15.791 61.461 20.406 1.00 0.00 H ATOM 5033 2HB GLU B 144 -17.460
60.941 20.552 1.00 0.00 H ATOM 5034 1HG GLU B 144 -16.520 63.373
18.878 1.00 0.00 H ATOM 5035 2HG GLU B 144 -17.181 63.464 20.537
1.00 0.00 H ATOM 5036 N ASP B 145 -16.834 58.331 19.171 1.00 0.22 N
ATOM 5037 CA ASP B 145 -16.438 57.030 19.619 1.00 0.22 C ATOM 5038
C ASP B 145 -15.451 56.448 18.657 1.00 0.22 C ATOM 5039 O ASP B 145
-14.495 55.797 19.079 1.00 0.22 O ATOM 5040 CB ASP B 145 -17.632
56.064 19.718 1.00 0.22 C ATOM 5041 CG ASP B 145 -17.196 54.793
20.435 1.00 0.22 C ATOM 5042 OD1 ASP B 145 -16.201 54.160 19.992
1.00 0.22 O ATOM 5043 OD2 ASP B 145 -17.856 54.442 21.448 1.00 0.22
O1- ATOM 5044 H ASP B 145 -17.800 58.450 18.901 1.00 0.00 H ATOM
5045 HA ASP B 145 -15.940 57.121 20.598 1.00 0.00 H ATOM 5046 1HB
ASP B 145 -17.956 55.760 18.717 1.00 0.00 H ATOM 5047 2HB ASP B 145
-18.467 56.523 20.264 1.00 0.00 H ATOM 5048 N SER B 146 -15.638
56.670 17.341 1.00 0.20 N ATOM 5049 CA SER B 146 -14.748 56.087
16.374 1.00 0.20 C ATOM 5050 C SER B 146 -13.344 56.482 16.696 1.00
0.20 C ATOM 5051 O SER B 146 -13.085 57.579 17.191 1.00 0.20 O ATOM
5052 CB SER B 146 -15.037 56.523 14.926 1.00 0.20 C ATOM 5053 OG
SER B 146 -14.798 57.915 14.780 1.00 0.20 O ATOM 5054 H SER B 146
-16.339 57.340 17.064 1.00 0.00 H ATOM 5055 HA SER B 146 -14.867
54.991 16.450 1.00 0.00 H ATOM 5056 1HB SER B 146 -16.065 56.298
14.651 1.00 0.00 H ATOM 5057 2HB SER B 146 -14.320 56.051 14.248
1.00 0.00 H ATOM 5058 HG SER B 146 -15.343 58.395 15.432 1.00 0.00
H ATOM 5059 N GLY B 147 -12.394 55.561 16.442 1.00 0.21 N ATOM 5060
CA GLY B 147 -11.020 55.841 16.735 1.00 0.21 C ATOM 5061 C GLY B
147 -10.301 54.535 16.762 1.00 0.21 C ATOM 5062 O GLY B 147 -10.814
53.517 16.299 1.00 0.21 O ATOM 5063 H GLY B 147 -12.613 54.654
16.041 1.00 0.00 H ATOM 5064 1HA GLY B 147 -10.942 56.340 17.716
1.00 0.00 H ATOM 5065 2HA GLY B 147 -10.567 56.502 15.975 1.00 0.00
H ATOM 5066 N THR B 148 -9.071 54.538 17.306 1.00 0.17 N ATOM 5067
CA THR B 148 -8.323 53.322 17.360 1.00 0.17 C ATOM 5068 C THR B 148
-8.332 52.870 18.779 1.00 0.17 C ATOM 5069 O THR B 148 -8.106
53.661 19.694 1.00 0.17 O ATOM 5070 CB THR B 148 -6.895 53.491
16.948 1.00 0.17 C ATOM 5071 OG1 THR B 148 -6.829 53.999 15.623
1.00 0.17 O ATOM 5072 CG2 THR B 148 -6.209 52.120 17.013 1.00 0.17
C ATOM 5073 H THR B 148 -8.624 55.388 17.678 1.00 0.00 H ATOM 5074
HA THR B 148 -8.767 52.588 16.674 1.00 0.00 H ATOM 5075 HB THR B
148 -6.364 54.181 17.632 1.00 0.00 H ATOM 5076 HG1 THR B 148 -7.244
54.874 15.660 1.00 0.00 H ATOM 5077 1HG2 THR B 148 -5.147 52.241
16.751 1.00 0.00 H ATOM 5078 2HG2 THR B 148 -6.308 51.719 18.025
1.00 0.00 H ATOM 5079 3HG2 THR B 148 -6.655 51.422 16.289 1.00 0.00
H ATOM 5080 N TYR B 149 -8.616 51.574 19.001 1.00 0.12 N ATOM 5081
CA TYR B 149 -8.660 51.076 20.343 1.00 0.12 C ATOM 5082 C TYR B 149
-7.643 49.994 20.494 1.00 0.12 C ATOM 5083 O TYR B 149 -7.419
49.197 19.586 1.00 0.12 O ATOM 5084 CB TYR B 149 -9.999 50.428
20.732 1.00 0.12 C ATOM 5085 CG TYR B 149 -11.045 51.479 20.866
1.00 0.12 C ATOM 5086 CD1 TYR B 149 -11.674 51.998 19.759 1.00 0.12
C ATOM 5087 CD2 TYR B 149 -11.402 51.932 22.113 1.00 0.12 C ATOM
5088 CE1 TYR B 149 -12.644 52.962 19.899 1.00 0.12 C ATOM 5089 CE2
TYR B 149 -12.372 52.895 22.260 1.00 0.12 C ATOM 5090 CZ TYR B 149
-12.993 53.412 21.150 1.00 0.12 C ATOM 5091 OH TYR B 149 -13.989
54.400 21.293 1.00 0.12 O ATOM 5092 H TYR B 149 -8.796 50.923
18.245 1.00 0.00 H ATOM 5093 HA TYR B 149 -8.441 51.899 21.010 1.00
0.00 H ATOM 5094 1HB TYR B 149 -9.845 49.950 21.708 1.00 0.00 H
ATOM 5095 2HB TYR B 149 -10.289 49.654 20.005 1.00 0.00 H ATOM 5096
HD1 TYR B 149 -11.402 51.655 18.764 1.00 0.00 H ATOM 5097 HD2 TYR B
149 -10.961 51.469 22.992 1.00 0.00 H ATOM 5098 HE1 TYR B 149
-13.123 53.373 19.011 1.00 0.00 H ATOM 5099 HE2 TYR B 149 -13.003
52.773 23.120 1.00 0.00 H ATOM 5100 HH TYR B 149 -14.641 54.316
20.555 1.00 0.00 H ATOM 5101 N TYR B 150 -6.980 49.968 21.666 1.00
0.12 N ATOM 5102 CA TYR B 150 -6.072 48.906 21.976 1.00 0.12 C ATOM
5103 C TYR B 150 -6.183 48.678 23.446 1.00 0.12 C ATOM 5104 O TYR B
150 -6.750 49.497 24.169 1.00 0.12 O ATOM 5105 CB TYR B 150 -4.574
49.181 21.581 1.00 0.12 C ATOM 5106 CG TYR B 150 -4.087 50.632
21.583 1.00 0.12 C ATOM 5107 CD1 TYR B 150 -2.898 50.942 22.234
1.00 0.12 C ATOM 5108 CD2 TYR B 150 -4.656 51.650 20.809 1.00 0.12
C ATOM 5109 CE1 TYR B 150 -2.277 52.174 22.099 1.00 0.12 C ATOM
5110 CE2 TYR B 150 -4.087 52.909 20.709 1.00 0.12 C ATOM 5111 CZ
TYR B 150 -2.865 53.188 21.343 1.00 0.12 C ATOM 5112 OH TYR B 150
-2.303 54.417 21.177 1.00 0.12 O ATOM 5113 H TYR B 150 -7.179
50.628 22.407 1.00 0.00 H ATOM 5114 HA TYR B 150 -6.417 47.983
21.478 1.00 0.00 H ATOM 5115 1HB TYR B 150 -4.376 48.771 20.583
1.00 0.00 H ATOM 5116 2HB TYR B 150 -3.930 48.575 22.238 1.00 0.00
H ATOM 5117 HD1 TYR B 150 -2.411 50.183 22.843 1.00 0.00 H ATOM
5118 HD2 TYR B 150 -5.552 51.456 20.231 1.00 0.00 H ATOM 5119 HE1
TYR B 150 -1.312 52.306 22.582 1.00 0.00 H ATOM 5120 HE2 TYR B 150
-4.566 53.669 20.094 1.00 0.00 H ATOM 5121 HH TYR B 150 -1.388
54.382 21.485 1.00 0.00 H ATOM 5122 N CYS B 151 -5.668 47.538
23.936 1.00 0.27 N ATOM 5123 CA CYS B 151 -5.851 47.259 25.325 1.00
0.27 C ATOM 5124 C CYS B 151 -4.536 46.869 25.912 1.00 0.27 C ATOM
5125 O CYS B 151 -3.648 46.384 25.215 1.00 0.27 O ATOM 5126 CB CYS
B 151 -6.843 46.104 25.548 1.00 0.27 C ATOM 5127 SG CYS B 151
-7.171 45.727 27.291 1.00 0.27 S ATOM 5128 H CYS B 151 -5.059
46.930 23.420 1.00 0.00 H ATOM 5129 HA CYS B 151 -6.218 48.148
25.849 1.00 0.00 H ATOM 5130 1HB CYS B 151 -6.499 45.191 25.037
1.00 0.00 H ATOM 5131 2HB CYS B 151 -7.796 46.404 25.083 1.00 0.00
H ATOM 5132 N THR B 152 -4.373 47.128 27.222 1.00 0.37 N ATOM 5133
CA THR B 152 -3.202 46.713 27.934 1.00 0.37 C ATOM 5134 C THR B 152
-3.659 45.920 29.104 1.00 0.37 C ATOM 5135 O THR B 152 -4.747
46.133 29.635 1.00 0.37 O ATOM 5136 CB THR B 152 -2.327 47.824
28.434 1.00 0.37 C ATOM 5137 OG1 THR B 152 -3.105 48.812 29.091
1.00 0.37 O ATOM 5138 CG2 THR B 152 -1.524 48.412 27.271 1.00 0.37
C ATOM 5139 H THR B 152 -5.082 47.588 27.778 1.00 0.00 H ATOM 5140
HA THR B 152 -2.623 46.045 27.283 1.00 0.00 H ATOM 5141 HB THR B
152 -1.602 47.395 29.156 1.00 0.00 H ATOM 5142 HG1 THR B 152 -2.553
49.611 29.152 1.00 0.00 H ATOM 5143 1HG2 THR B 152 -0.892 49.248
27.611 1.00 0.00 H ATOM 5144 2HG2 THR B 152 -0.852 47.655 26.850
1.00 0.00 H ATOM 5145 3HG2 THR B 152 -2.185 48.790 26.476 1.00 0.00
H ATOM 5146 N GLY B 153 -2.829 44.947 29.520 1.00 0.21 N ATOM 5147
CA GLY B 153 -3.195 44.136 30.637 1.00 0.21 C ATOM 5148 C GLY B 153
-1.974 43.392 31.040 1.00 0.21 C ATOM 5149 O GLY B 153 -1.021
43.278 30.271 1.00 0.21 O ATOM 5150 H GLY B 153 -1.886 44.837
29.146 1.00 0.00 H ATOM 5151 1HA GLY B 153 -3.993 43.422 30.370
1.00 0.00 H ATOM 5152 2HA GLY B 153 -3.543 44.766 31.450 1.00 0.00
H ATOM 5153 N LYS B 154 -1.972 42.860 32.275 1.00 0.12 N ATOM 5154
CA LYS B 154 -0.807 42.155 32.702 1.00 0.12 C ATOM 5155 C LYS B 154
-1.155 40.715 32.821 1.00 0.12 C ATOM 5156 O LYS B 154 -2.059
40.336 33.565 1.00 0.12 O ATOM 5157 CB LYS B 154 -0.290 42.601
34.077 1.00 0.12 C ATOM 5158 CG LYS B 154 0.176 44.056 34.106 1.00
0.12 C ATOM 5159 CD LYS B 154 0.395 44.591 35.521 1.00 0.12 C ATOM
5160 CE LYS B 154 0.863 46.048 35.557 1.00 0.12 C ATOM 5161 NZ LYS
B 154 1.046 46.488 36.959 1.00 0.12 N1+ ATOM 5162 H LYS B 154
-2.733 42.972 32.935 1.00 0.00 H ATOM 5163 HA LYS B 154 -0.031
42.235 31.958 1.00 0.00 H ATOM 5164 1HB LYS B 154 0.526 41.927
34.362 1.00 0.00 H ATOM 5165 2HB LYS B 154 -1.176 42.511 34.684
1.00 0.00 H ATOM 5166 1HG LYS B 154 -0.548 44.710 33.586 1.00 0.00
H ATOM 5167 2HG LYS B 154 1.115 44.114 33.543 1.00 0.00 H ATOM 5168
1HD LYS B 154 1.072 43.927 36.083 1.00 0.00 H ATOM 5169 2HD LYS B
154 -0.602 44.565 35.950 1.00 0.00 H ATOM 5170 1HE LYS B 154 0.129
46.719 35.080 1.00 0.00 H ATOM 5171 2HE LYS B 154 1.829 46.180
35.041 1.00 0.00 H ATOM 5172 1HZ LYS B 154 1.435 47.422 36.999 1.00
0.00 H ATOM 5173 2HZ LYS B 154 0.179 46.508 37.465 1.00 0.00 H ATOM
5174 3HZ LYS B 154 1.701 45.889 37.446 1.00 0.00 H ATOM 5175 N VAL
B 155 -0.441 39.872 32.056 1.00 0.20 N ATOM 5176 CA VAL B 155
-0.620 38.462 32.171 1.00 0.20 C ATOM 5177 C VAL B 155 0.646 37.984
32.782 1.00 0.20 C ATOM 5178 O VAL B 155 1.735 38.387 32.374 1.00
0.20 O ATOM 5179 CB VAL B 155 -0.804 37.761 30.854 1.00 0.20 C ATOM
5180 CG1 VAL B 155 -2.117 38.254 30.221 1.00 0.20 C ATOM 5181 CG2
VAL B 155 0.439 38.013 29.983 1.00 0.20 C ATOM 5182 H VAL B 155
0.465 40.165 31.706 1.00 0.00 H ATOM 5183 HA VAL B 155 -1.474
38.239 32.829 1.00 0.00 H ATOM 5184 HB VAL B 155 -0.898 36.681
31.070 1.00 0.00 H ATOM 5185 1HG1 VAL B 155 -2.526 37.547 29.484
1.00 0.00 H ATOM 5186 2HG1 VAL B 155 -2.861 38.423 31.007 1.00 0.00
H ATOM 5187 3HG1 VAL B 155 -1.975 39.222 29.711 1.00 0.00 H ATOM
5188 1HG2 VAL B 155 0.249 37.694 28.942 1.00 0.00 H ATOM 5189 2HG2
VAL B 155 0.649 39.081 29.939 1.00 0.00 H ATOM 5190 3HG2 VAL B 155
1.343 37.475 30.285 1.00 0.00 H ATOM 5191 N TRP B 156 0.539 37.143
33.820 1.00 0.33 N ATOM 5192 CA TRP B 156 1.740 36.713 34.455 1.00
0.33 C ATOM 5193 C TRP B 156 2.323 37.955 35.034 1.00 0.33 C ATOM
5194 O TRP B 156 1.605 38.904 35.350 1.00 0.33 O ATOM 5195 CB TRP B
156 2.765 36.100 33.483 1.00 0.33 C ATOM 5196 CG TRP B 156 2.277
34.858 32.771 1.00 0.33 C ATOM 5197 CD1 TRP B 156 1.694 34.753
31.543 1.00 0.33 C ATOM 5198 CD2 TRP B 156 2.345 33.525 33.303 1.00
0.33 C ATOM 5199 NE1 TRP B 156 1.392 33.439 31.275 1.00 0.33 N ATOM
5200 CE2 TRP B 156 1.787 32.671 32.350 1.00 0.33 C ATOM 5201 CE3
TRP B 156 2.832 33.050 34.487 1.00 0.33 C ATOM 5202 CZ2 TRP B 156
1.705 31.325 32.569 1.00 0.33 C ATOM 5203 CZ3 TRP B 156 2.748
31.691 34.703 1.00 0.33 C ATOM 5204 CH2 TRP B 156 2.195 30.845
33.763 1.00 0.33 C ATOM 5205 H TRP B 156 -0.349 36.804 34.155 1.00
0.00 H ATOM 5206 HA TRP B 156 1.505 36.007 35.270 1.00 0.00 H ATOM
5207 1HB TRP B 156 3.617 35.752 34.092 1.00 0.00 H ATOM 5208 2HB
TRP B 156 3.230 36.786 32.765 1.00 0.00 H ATOM 5209 HD1 TRP B 156
1.470 35.527 30.827
1.00 0.00 H ATOM 5210 HE1 TRP B 156 0.852 33.107 30.508 1.00 0.00 H
ATOM 5211 HE3 TRP B 156 3.265 33.702 35.237 1.00 0.00 H ATOM 5212
HZ2 TRP B 156 1.272 30.662 31.826 1.00 0.00 H ATOM 5213 HZ3 TRP B
156 3.122 31.273 35.635 1.00 0.00 H ATOM 5214 HH2 TRP B 156 2.143
29.779 33.972 1.00 0.00 H ATOM 5215 N GLN B 157 3.656 37.967 35.190
1.00 0.49 N ATOM 5216 CA GLN B 157 4.338 39.097 35.739 1.00 0.49 C
ATOM 5217 C GLN B 157 4.276 40.236 34.773 1.00 0.49 C ATOM 5218 O
GLN B 157 4.048 41.381 35.160 1.00 0.49 O ATOM 5219 CB GLN B 157
5.830 38.816 35.969 1.00 0.49 C ATOM 5220 CG GLN B 157 6.082 37.569
36.814 1.00 0.49 C ATOM 5221 CD GLN B 157 5.294 37.721 38.101 1.00
0.49 C ATOM 5222 OE1 GLN B 157 5.354 38.759 38.756 1.00 0.49 O ATOM
5223 NE2 GLN B 157 4.525 36.663 38.466 1.00 0.49 N ATOM 5224 H GLN
B 157 4.224 37.178 34.941 1.00 0.00 H ATOM 5225 HA GLN B 157 3.849
39.413 36.673 1.00 0.00 H ATOM 5226 1HB GLN B 157 6.280 39.706
36.442 1.00 0.00 H ATOM 5227 2HB GLN B 157 6.355 38.651 35.031 1.00
0.00 H ATOM 5228 1HG GLN B 157 7.147 37.485 37.094 1.00 0.00 H ATOM
5229 2HG GLN B 157 5.821 36.652 36.260 1.00 0.00 H ATOM 5230 1HE2
GLN B 157 4.495 35.810 37.942 1.00 0.00 H ATOM 5231 2HE2 GLN B 157
3.997 36.763 39.316 1.00 0.00 H ATOM 5232 N LEU B 158 4.459 39.934
33.473 1.00 0.41 N ATOM 5233 CA LEU B 158 4.607 40.961 32.483 1.00
0.41 C ATOM 5234 C LEU B 158 3.306 41.597 32.127 1.00 0.41 C ATOM
5235 O LEU B 158 2.227 41.063 32.381 1.00 0.41 O ATOM 5236 CB LEU B
158 5.252 40.467 31.176 1.00 0.41 C ATOM 5237 CG LEU B 158 6.699
39.977 31.364 1.00 0.41 C ATOM 5238 CD1 LEU B 158 7.628 41.124
31.796 1.00 0.41 C ATOM 5239 CD2 LEU B 158 6.758 38.765 32.310 1.00
0.41 C ATOM 5240 H LEU B 158 4.371 38.990 33.144 1.00 0.00 H ATOM
5241 HA LEU B 158 5.247 41.746 32.926 1.00 0.00 H ATOM 5242 1HB LEU
B 158 5.231 41.276 30.425 1.00 0.00 H ATOM 5243 2HB LEU B 158 4.656
39.640 30.773 1.00 0.00 H ATOM 5244 HG LEU B 158 7.047 39.639
30.367 1.00 0.00 H ATOM 5245 1HD1 LEU B 158 8.682 40.800 31.788
1.00 0.00 H ATOM 5246 2HD1 LEU B 158 7.548 41.983 31.109 1.00 0.00
H ATOM 5247 3HD1 LEU B 158 7.408 41.481 32.814 1.00 0.00 H ATOM
5248 1HD2 LEU B 158 7.652 38.158 32.086 1.00 0.00 H ATOM 5249 2HD2
LEU B 158 6.896 39.116 33.331 1.00 0.00 H ATOM 5250 3HD2 LEU B 158
5.894 38.090 32.222 1.00 0.00 H ATOM 5251 N ASP B 159 3.419 42.804
31.533 1.00 0.19 N ATOM 5252 CA ASP B 159 2.310 43.578 31.058 1.00
0.19 C ATOM 5253 C ASP B 159 2.414 43.543 29.566 1.00 0.19 C ATOM
5254 O ASP B 159 3.504 43.668 29.009 1.00 0.19 O ATOM 5255 CB ASP B
159 2.381 45.057 31.503 1.00 0.19 C ATOM 5256 CG ASP B 159 1.124
45.839 31.117 1.00 0.19 C ATOM 5257 OD1 ASP B 159 0.378 45.398
30.205 1.00 0.19 O ATOM 5258 OD2 ASP B 159 0.904 46.910 31.744 1.00
0.19 O1- ATOM 5259 H ASP B 159 4.304 43.201 31.275 1.00 0.00 H ATOM
5260 HA ASP B 159 1.394 43.142 31.412 1.00 0.00 H ATOM 5261 1HB ASP
B 159 3.242 45.547 31.017 1.00 0.00 H ATOM 5262 2HB ASP B 159 2.576
45.164 32.581 1.00 0.00 H ATOM 5263 N TYR B 160 1.279 43.335 28.874
1.00 0.11 N ATOM 5264 CA TYR B 160 1.321 43.282 27.443 1.00 0.11 C
ATOM 5265 C TYR B 160 0.381 44.304 26.901 1.00 0.11 C ATOM 5266 O
TYR B 160 -0.535 44.755 27.589 1.00 0.11 O ATOM 5267 CB TYR B 160
0.884 41.929 26.857 1.00 0.11 C ATOM 5268 CG TYR B 160 1.939 40.924
27.171 1.00 0.11 C ATOM 5269 CD1 TYR B 160 2.067 40.404 28.439 1.00
0.11 C ATOM 5270 CD2 TYR B 160 2.794 40.488 26.185 1.00 0.11 C ATOM
5271 CE1 TYR B 160 3.042 39.476 28.720 1.00 0.11 C ATOM 5272 CE2
TYR B 160 3.771 39.560 26.459 1.00 0.11 C ATOM 5273 CZ TYR B 160
3.895 39.052 27.730 1.00 0.11 C ATOM 5274 OH TYR B 160 4.895 38.099
28.019 1.00 0.11 O ATOM 5275 H TYR B 160 0.420 43.679 29.317 1.00
0.00 H ATOM 5276 HA TYR B 160 2.324 43.539 27.087 1.00 0.00 H ATOM
5277 1HB TYR B 160 0.755 42.037 25.769 1.00 0.00 H ATOM 5278 2HB
TYR B 160 -0.098 41.635 27.262 1.00 0.00 H ATOM 5279 HD1 TYR B 160
1.419 40.777 29.225 1.00 0.00 H ATOM 5280 HD2 TYR B 160 2.708
40.890 25.178 1.00 0.00 H ATOM 5281 HE1 TYR B 160 3.087 39.038
29.711 1.00 0.00 H ATOM 5282 HE2 TYR B 160 4.440 39.242 25.662 1.00
0.00 H ATOM 5283 HH TYR B 160 5.695 38.392 27.561 1.00 0.00 H ATOM
5284 N GLU B 161 0.622 44.722 25.643 1.00 0.12 N ATOM 5285 CA GLU B
161 -0.262 45.647 25.000 1.00 0.12 C ATOM 5286 C GLU B 161 -0.753
44.973 23.762 1.00 0.12 C ATOM 5287 O GLU B 161 -0.033 44.197
23.135 1.00 0.12 O ATOM 5288 CB GLU B 161 0.273 47.006 24.485 1.00
0.12 C ATOM 5289 CG GLU B 161 -0.616 48.163 23.930 1.00 0.12 C ATOM
5290 CD GLU B 161 0.100 48.894 22.732 1.00 0.12 C ATOM 5291 OE1 GLU
B 161 0.523 48.163 21.832 1.00 0.12 O ATOM 5292 OE2 GLU B 161 0.153
50.124 22.811 1.00 0.12 O1- ATOM 5293 H GLU B 161 1.327 44.317
25.048 1.00 0.00 H ATOM 5294 HA GLU B 161 -1.119 45.827 25.660 1.00
0.00 H ATOM 5295 1HB GLU B 161 0.959 46.729 23.673 1.00 0.00 H ATOM
5296 2HB GLU B 161 0.855 47.435 25.316 1.00 0.00 H ATOM 5297 1HG
GLU B 161 -0.844 48.899 24.714 1.00 0.00 H ATOM 5298 2HG GLU B 161
-1.583 47.807 23.551 1.00 0.00 H ATOM 5299 N SER B 162 -2.020
45.234 23.397 1.00 0.11 N ATOM 5300 CA SER B 162 -2.598 44.616
22.242 1.00 0.11 C ATOM 5301 C SER B 162 -2.381 45.499 21.065 1.00
0.11 C ATOM 5302 O SER B 162 -1.967 46.650 21.196 1.00 0.11 O ATOM
5303 CB SER B 162 -4.113 44.377 22.371 1.00 0.11 C ATOM 5304 OG SER
B 162 -4.614 43.756 21.196 1.00 0.11 O ATOM 5305 H SER B 162 -2.583
45.884 23.935 1.00 0.00 H ATOM 5306 HA SER B 162 -2.119 43.636
22.074 1.00 0.00 H ATOM 5307 1HB SER B 162 -4.658 45.313 22.560
1.00 0.00 H ATOM 5308 2HB SER B 162 -4.320 43.696 23.199 1.00 0.00
H ATOM 5309 HG SER B 162 -4.572 44.455 20.511 1.00 0.00 H ATOM 5310
N GLU B 163 -2.640 44.951 19.864 1.00 0.13 N ATOM 5311 CA GLU B 163
-2.517 45.715 18.661 1.00 0.13 C ATOM 5312 C GLU B 163 -3.757
46.533 18.544 1.00 0.13 C ATOM 5313 O GLU B 163 -4.830 46.148
19.006 1.00 0.13 O ATOM 5314 CB GLU B 163 -2.382 44.835 17.407 1.00
0.13 C ATOM 5315 CG GLU B 163 -3.567 43.890 17.202 1.00 0.13 C ATOM
5316 CD GLU B 163 -3.153 42.846 16.177 1.00 0.13 C ATOM 5317 OE1
GLU B 163 -2.076 42.223 16.381 1.00 0.13 O ATOM 5318 OE2 GLU B 163
-3.900 42.654 15.181 1.00 0.13 O1- ATOM 5319 H GLU B 163 -2.775
43.955 19.742 1.00 0.00 H ATOM 5320 HA GLU B 163 -1.567 46.269
18.725 1.00 0.00 H ATOM 5321 1HB GLU B 163 -1.436 44.272 17.498
1.00 0.00 H ATOM 5322 2HB GLU B 163 -2.268 45.510 16.541 1.00 0.00
H ATOM 5323 1HG GLU B 163 -4.480 44.422 16.897 1.00 0.00 H ATOM
5324 2HG GLU B 163 -3.770 43.349 18.136 1.00 0.00 H ATOM 5325 N PRO
B 164 -3.611 47.681 17.956 1.00 0.13 N ATOM 5326 CA PRO B 164
-4.751 48.542 17.819 1.00 0.13 C ATOM 5327 C PRO B 164 -5.680
48.070 16.752 1.00 0.13 C ATOM 5328 O PRO B 164 -5.235 47.407
15.818 1.00 0.13 O ATOM 5329 CB PRO B 164 -4.189 49.936 17.565 1.00
0.13 C ATOM 5330 CG PRO B 164 -2.815 49.909 18.251 1.00 0.13 C ATOM
5331 CD PRO B 164 -2.385 48.437 18.167 1.00 0.13 C ATOM 5332 HA PRO
B 164 -5.283 48.566 18.778 1.00 0.00 H ATOM 5333 1HB PRO B 164
-4.771 50.682 18.086 1.00 0.00 H ATOM 5334 2HB PRO B 164 -4.110
50.174 16.494 1.00 0.00 H ATOM 5335 1HG PRO B 164 -2.913 50.209
19.302 1.00 0.00 H ATOM 5336 2HG PRO B 164 -2.076 50.592 17.804
1.00 0.00 H ATOM 5337 1HD PRO B 164 -1.699 48.263 17.323 1.00 0.00
H ATOM 5338 2HD PRO B 164 -1.875 48.165 19.100 1.00 0.00 H ATOM
5339 N LEU B 165 -6.982 48.383 16.888 1.00 0.11 N ATOM 5340 CA LEU
B 165 -7.932 48.026 15.879 1.00 0.11 C ATOM 5341 C LEU B 165 -8.678
49.279 15.565 1.00 0.11 C ATOM 5342 O LEU B 165 -8.896 50.112
16.444 1.00 0.11 O ATOM 5343 CB LEU B 165 -8.953 46.969 16.327 1.00
0.11 C ATOM 5344 CG LEU B 165 -8.309 45.618 16.688 1.00 0.11 C ATOM
5345 CD1 LEU B 165 -9.377 44.562 17.011 1.00 0.11 C ATOM 5346 CD2
LEU B 165 -7.321 45.158 15.605 1.00 0.11 C ATOM 5347 H LEU B 165
-7.332 48.855 17.713 1.00 0.00 H ATOM 5348 HA LEU B 165 -7.399
47.693 14.975 1.00 0.00 H ATOM 5349 1HB LEU B 165 -9.663 46.827
15.492 1.00 0.00 H ATOM 5350 2HB LEU B 165 -9.540 47.354 17.180
1.00 0.00 H ATOM 5351 HG LEU B 165 -7.725 45.756 17.619 1.00 0.00 H
ATOM 5352 1HD1 LEU B 165 -8.889 43.616 17.270 1.00 0.00 H ATOM 5353
2HD1 LEU B 165 -10.014 44.907 17.841 1.00 0.00 H ATOM 5354 3HD1 LEU
B 165 -10.046 44.410 16.150 1.00 0.00 H ATOM 5355 1HD2 LEU B 165
-7.258 44.060 15.620 1.00 0.00 H ATOM 5356 2HD2 LEU B 165 -7.617
45.460 14.591 1.00 0.00 H ATOM 5357 3HD2 LEU B 165 -6.293 45.461
15.796 1.00 0.00 H ATOM 5358 N ASN B 166 -9.077 49.464 14.294 1.00
0.10 N ATOM 5359 CA ASN B 166 -9.772 50.674 13.976 1.00 0.10 C ATOM
5360 C ASN B 166 -11.234 50.388 14.008 1.00 0.10 C ATOM 5361 O ASN
B 166 -11.729 49.520 13.291 1.00 0.10 O ATOM 5362 CB ASN B 166
-9.460 51.243 12.581 1.00 0.10 C ATOM 5363 CG ASN B 166 -8.056
51.831 12.593 1.00 0.10 C ATOM 5364 OD1 ASN B 166 -7.304 51.681
13.555 1.00 0.10 O ATOM 5365 ND2 ASN B 166 -7.695 52.538 11.490
1.00 0.10 N ATOM 5366 H ASN B 166 -8.920 48.814 13.545 1.00 0.00 H
ATOM 5367 HA ASN B 166 -9.511 51.470 14.693 1.00 0.00 H ATOM 5368
1HB ASN B 166 -10.185 52.051 12.379 1.00 0.00 H ATOM 5369 2HB ASN B
166 -9.555 50.487 11.785 1.00 0.00 H ATOM 5370 1HD2 ASN B 166
-8.314 52.676 10.714 1.00 0.00 H ATOM 5371 2HD2 ASN B 166 -6.780
52.955 11.511 1.00 0.00 H ATOM 5372 N ILE B 167 -11.959 51.119
14.873 1.00 0.22 N ATOM 5373 CA ILE B 167 -13.378 50.962 14.942
1.00 0.22 C ATOM 5374 C ILE B 167 -13.954 52.275 14.545 1.00 0.22 C
ATOM 5375 O ILE B 167 -13.535 53.322 15.035 1.00 0.22 O ATOM 5376
CB ILE B 167 -13.880 50.650 16.322 1.00 0.22 C ATOM 5377 CG1 ILE B
167 -13.316 49.304 16.805 1.00 0.22 C ATOM 5378 CG2 ILE B 167
-15.418 50.705 16.294 1.00 0.22 C ATOM 5379 CD1 ILE B 167 -13.532
49.051 18.297 1.00 0.22 C ATOM 5380 H ILE B 167 -11.568 51.884
15.416 1.00 0.00 H ATOM 5381 HA ILE B 167 -13.699 50.161 14.261
1.00 0.00 H ATOM 5382 HB ILE B 167 -13.530 51.440 17.014 1.00 0.00
H ATOM 5383 1HG1 ILE B 167 -12.227 49.256 16.623 1.00 0.00 H ATOM
5384 2HG1 ILE B 167 -13.758 48.478 16.219 1.00 0.00 H ATOM 5385
1HG2 ILE B 167 -15.829 50.544 17.306 1.00 0.00 H ATOM 5386 2HG2 ILE
B 167 -15.817 51.680 15.976 1.00 0.00 H ATOM 5387 3HG2 ILE B 167
-15.851 49.914 15.670 1.00 0.00 H ATOM 5388 1HD1 ILE B 167 -13.011
48.136 18.621 1.00 0.00 H ATOM 5389 2HD1 ILE B 167 -13.158 49.884
18.909 1.00 0.00 H ATOM 5390 3HD1 ILE B 167 -14.602 48.923 18.511
1.00 0.00 H ATOM 5391 N THR B 168 -14.926 52.262 13.618 1.00 0.48 N
ATOM 5392 CA THR B 168 -15.488 53.513 13.212 1.00 0.48 C ATOM 5393
C THR B 168 -16.955 53.470 13.410 1.00 0.48 C ATOM 5394 O THR B 168
-17.587 52.419 13.312 1.00 0.48 O ATOM 5395 CB THR B 168 -15.289
53.846 11.764 1.00 0.48 C ATOM 5396 OG1 THR B 168 -15.798 52.802
10.948 1.00 0.48 O ATOM 5397 CG2 THR B 168 -13.800 54.078 11.494
1.00 0.48 C ATOM 5398 H THR B 168 -15.333 51.415 13.242 1.00 0.00 H
ATOM 5399 HA THR B 168 -15.086 54.315 13.823 1.00 0.00 H ATOM 5400
HB THR B 168 -15.828 54.788 11.542 1.00 0.00 H ATOM 5401 HG1 THR B
168 -16.752 52.753 11.109 1.00 0.00 H ATOM 5402 1HG2 THR B 168
-13.629 54.378 10.447 1.00 0.00 H ATOM 5403 2HG2 THR B 168 -13.392
54.871 12.141 1.00 0.00 H ATOM 5404 3HG2 THR B 168 -13.218 53.159
11.670 1.00 0.00 H ATOM 5405 N VAL B 169 -17.538 54.638 13.724 1.00
0.55 N ATOM 5406 CA VAL B 169 -18.958 54.667 13.795 1.00 0.55 C
ATOM 5407 C VAL B 169 -19.375 55.038 12.415 1.00 0.55 C ATOM 5408 O
VAL B 169 -18.935 56.046 11.863 1.00 0.55 O ATOM 5409 CB VAL B 169
-19.532 55.659 14.771 1.00 0.55 C ATOM 5410 CG1 VAL B 169 -19.096
55.245 16.183 1.00 0.55 C ATOM 5411 CG2 VAL B 169 -19.102 57.084
14.391 1.00 0.55 C ATOM 5412 H VAL B 169 -17.097 55.537 13.643 1.00
0.00 H ATOM 5413 HA VAL B 169 -19.344 53.676 14.069 1.00 0.00 H
ATOM 5414 HB VAL B 169 -20.631 55.570 14.679 1.00 0.00 H ATOM 5415
1HG1 VAL B 169 -19.882 55.434 16.925 1.00 0.00 H ATOM 5416 2HG1 VAL
B 169 -18.919 54.158 16.250 1.00 0.00 H ATOM 5417 3HG1 VAL B 169
-18.150 55.715 16.482 1.00 0.00 H ATOM 5418 1HG2 VAL B 169 -19.962
57.610 14.838 1.00 0.00 H ATOM 5419 2HG2 VAL B 169 -18.107 57.258
14.822 1.00 0.00 H ATOM 5420 3HG2 VAL B 169 -19.091 57.488 13.385
1.00 0.00 H ATOM 5421 N ILE B 170 -20.221 54.194 11.807 1.00 0.56 N
ATOM 5422 CA ILE B 170 -20.637 54.415 10.457 1.00 0.56 C ATOM 5423
C ILE B 170 -21.357 55.721 10.428 1.00 0.56 C ATOM 5424 O ILE B 170
-21.198 56.502 9.490 1.00 0.56 O ATOM 5425 CB ILE B 170 -21.546
53.321 9.942 1.00 0.56 C ATOM 5426 CG1 ILE B 170 -21.728 53.399
8.414 1.00 0.56 C ATOM 5427 CG2 ILE B 170 -22.867 53.374 10.727
1.00 0.56 C ATOM 5428 CD1 ILE B 170 -22.467 54.643 7.921 1.00 0.56
C ATOM 5429 H ILE B 170 -20.615 53.381 12.272 1.00 0.00 H ATOM 5430
HA ILE B 170 -19.739 54.517 9.824 1.00 0.00 H ATOM 5431 HB ILE B
170 -21.142 52.353 10.164 1.00 0.00 H ATOM 5432 1HG1 ILE B 170
-22.296 52.506 8.094 1.00 0.00 H ATOM 5433 2HG1 ILE B 170 -20.748
53.323 7.909 1.00 0.00 H ATOM 5434 1HG2 ILE B 170 -23.219 52.342
10.855 1.00 0.00 H ATOM 5435 2HG2 ILE B 170 -22.796 53.819 11.714
1.00 0.00 H ATOM 5436 3HG2 ILE B 170 -23.675 53.912 10.210 1.00
0.00 H ATOM 5437 1HD1 ILE B 170 -23.115 54.369 7.070 1.00 0.00 H
ATOM 5438 2HD1 ILE B 170 -23.131 55.124 8.651 1.00 0.00 H ATOM 5439
3HD1 ILE B 170 -21.776 55.394 7.510 1.00 0.00 H ATOM 5440 N LYS B
171 -22.156 55.999 11.475 1.00 0.52 N ATOM 5441 CA LYS B 171
-22.902 57.220 11.537 1.00 0.52 C ATOM 5442 C LYS B 171 -21.908
58.330 11.406 1.00 0.52 C ATOM 5443 O LYS B 171 -20.957 58.418
12.180 1.00 0.52 O ATOM 5444 CB LYS B 171 -23.649 57.356 12.879
1.00 0.52 C ATOM 5445 CG LYS B 171 -24.731 58.436 12.935 1.00 0.52
C ATOM 5446 CD LYS B 171 -24.206 59.860 12.790 1.00 0.52 C ATOM
5447 CE LYS B 171 -25.263 60.932 13.064 1.00 0.52 C ATOM 5448 NZ
LYS B 171 -26.436 60.713 12.190 1.00 0.52 N1+ ATOM 5449 H LYS B 171
-22.064 55.447 12.309 1.00 0.00 H ATOM 5450 HA LYS B 171 -23.632
57.218 10.707 1.00 0.00 H ATOM 5451 1HB LYS B 171 -22.872 57.525
13.643 1.00 0.00 H ATOM 5452 2HB LYS B 171 -24.129 56.387 13.070
1.00 0.00 H ATOM 5453 1HG LYS B 171 -25.345 58.368 13.836 1.00 0.00
H ATOM 5454 2HG LYS B 171 -25.440 58.243 12.108 1.00 0.00 H ATOM
5455 1HD LYS B 171 -23.965 59.931 11.730 1.00 0.00 H ATOM 5456 2HD
LYS B 171 -23.301 60.050 13.389 1.00 0.00 H ATOM 5457 1HE LYS B 171
-24.878 61.943 12.854 1.00 0.00 H ATOM 5458 2HE LYS B 171 -25.630
60.929 14.101 1.00 0.00 H ATOM 5459 1HZ LYS B 171 -27.152 61.412
12.333 1.00 0.00 H ATOM 5460 2HZ LYS B 171 -26.174 60.754 11.214
1.00 0.00 H ATOM 5461 3HZ LYS B 171 -26.861 59.813 12.366 1.00 0.00
H ATOM 5462 N ALA B 172 -22.097 59.199 10.393 1.00 0.31 N ATOM 5463
CA ALA B 172 -21.148 60.249 10.164 1.00 0.31 C ATOM 5464 C ALA B
172 -21.773 61.594 10.514 1.00 0.31 C ATOM 5465 O ALA B 172 -21.349
62.615 9.889 1.00 0.31 O ATOM 5466 CB ALA B 172 -20.692 60.342
8.698 1.00 0.31 C ATOM 5467 OXT ALA B 172 -22.672 61.637 11.410
1.00 0.31 O1- ATOM 5468 H ALA B 172 -22.806 59.090 9.697 1.00 0.00
H ATOM 5469 HA ALA B 172 -20.253 60.101 10.785 1.00 0.00 H ATOM
5470 1HB ALA B 172 -19.856 61.055 8.602 1.00 0.00 H ATOM 5471 2HB
ALA B 172 -20.320 59.375 8.320 1.00 0.00 H ATOM 5472 3HB ALA B 172
-21.505 60.668 8.030 1.00 0.00 H TER
[0146]
5TABLE 5 REMARK Model of Fc Gamma Receptor type IIIb; V. C. Epa,
Feb 02, 1999. REMARK r3b_Mod8.B99990013.pdb REMARK Produced
byMODELLER: 02-Feb-99 01:55:11 1 REMARK MODELLER OBJECTIVE
FUNCTION: 933.2556 ATOM 1 N ARG 1 36.333 78.544 5.582 1.00 0.75 1SG
2 ATOM 2 CA ARG 1 36.665 78.748 7.009 1.00 0.75 1SG 3 ATOM 3 CB ARG
1 37.362 80.102 7.211 1.00 0.75 1SG 4 ATOM 4 CG ARG 1 38.684 80.236
6.455 1.00 0.75 1SG 5 ATOM 5 CD ARG 1 39.381 81.577 6.691 1.00 0.75
1SG 6 ATOM 6 NE ARG 1 38.454 82.648 6.231 1.00 0.75 1SG 7 ATOM 7 CZ
ARG 1 38.575 83.911 6.733 1.00 0.75 1SG 8 ATOM 8 NH1 ARG 1 39.561
84.195 7.632 1.00 0.75 1SG 9 ATOM 9 NH2 ARG 1 37.706 84.888 6.342
1.00 0.75 1SG 10 ATOM 10 C ARG 1 35.413 78.755 7.815 1.00 0.75 1SG
11 ATOM 11 O ARG 1 34.422 78.125 7.448 1.00 0.75 1SG 12 ATOM 12 N
THR 2 35.435 79.465 8.957 1.00 0.84 1SG 13 ATOM 13 CA THR 2 34.253
79.541 9.758 1.00 0.84 1SG 14 ATOM 14 CB THR 2 34.507 79.998 11.165
1.00 0.84 1SG 15 ATOM 15 OG1 THR 2 35.036 81.316 11.166 1.00 0.84
1SG 16 ATOM 16 CG2 THR 2 35.505 79.029 11.821 1.00 0.84 1SG 17 ATOM
17 C THR 2 33.378 80.548 9.098 1.00 0.84 1SG 18 ATOM 18 O THR 2
33.857 81.407 8.359 1.00 0.84 1SG 19 ATOM 19 N GLU 3 32.057 80.458
9.329 1.00 0.71 1SG 20 ATOM 20 CA GLU 3 31.181 81.396 8.699 1.00
0.71 1SG 21 ATOM 21 CB GLU 3 29.830 80.782 8.299 1.00 0.71 1SG 22
ATOM 22 CG GLU 3 29.965 79.711 7.214 1.00 0.71 1SG 23 ATOM 23 CD
GLU 3 30.554 80.365 5.972 1.00 0.71 1SG 24 ATOM 24 OE1 GLU 3 30.739
81.612 5.991 1.00 0.71 1SG 25 ATOM 25 OE2 GLU 3 30.827 79.627 4.988
1.00 0.71 1SG 26 ATOM 26 C GLU 3 30.937 82.497 9.675 1.00 0.71 1SG
27 ATOM 27 O GLU 3 30.388 82.277 10.753 1.00 0.71 1SG 28 ATOM 28 N
ASP 4 31.367 83.722 9.318 1.00 0.37 1SG 29 ATOM 29 CA ASP 4 31.218
84.828 10.215 1.00 0.37 1SG 30 ATOM 30 CB ASP 4 31.857 86.122 9.684
1.00 0.37 1SG 31 ATOM 31 CG ASP 4 33.370 85.958 9.723 1.00 0.37 1SG
32 ATOM 32 OD1 ASP 4 33.845 85.029 10.428 1.00 0.37 1SG 33 ATOM 33
OD2 ASP 4 34.070 86.765 9.055 1.00 0.37 1SG 34 ATOM 34 C ASP 4
29.767 85.099 10.401 1.00 0.37 1SG 35 ATOM 35 O ASP 4 29.251 85.050
11.516 1.00 0.37 1SG 36 ATOM 36 N LEU 5 29.059 85.370 9.294 1.00
0.17 1SG 37 ATOM 37 CA LEU 5 27.667 85.668 9.399 1.00 0.17 1SG 38
ATOM 38 CB LEU 5 27.075 86.177 8.075 1.00 0.17 1SG 39 ATOM 39 CG
LEU 5 27.732 87.486 7.592 1.00 0.17 1SG 40 ATOM 40 CD2 LEU 5 27.709
88.560 8.693 1.00 0.17 1SG 41 ATOM 41 CD1 LEU 5 27.115 87.974 6.271
1.00 0.17 1SG 42 ATOM 42 C LEU 5 26.999 84.375 9.734 1.00 0.17 1SG
43 ATOM 43 O LEU 5 27.436 83.315 9.290 1.00 0.17 1SG 44 ATOM 44 N
PRO 6 25.939 84.428 10.491 1.00 0.32 1SG 45 ATOM 45 CA PRO 6 25.286
83.214 10.886 1.00 0.32 1SG 46 ATOM 46 CD PRO 6 25.749 85.492
11.462 1.00 0.32 1SG 47 ATOM 47 CB PRO 6 24.243 83.628 11.919 1.00
0.32 1SG 48 ATOM 48 CG PRO 6 24.865 84.882 12.566 1.00 0.32 1SG 49
ATOM 49 C PRO 6 24.755 82.520 9.679 1.00 0.32 1SG 50 ATOM 50 O PRO
6 24.506 83.182 8.672 1.00 0.32 1SG 51 ATOM 51 N LYS 7 24.603
81.184 9.741 1.00 0.49 1SG 52 ATOM 52 CA LYS 7 24.184 80.476 8.572
1.00 0.49 1SG 53 ATOM 53 CB LYS 7 24.543 78.979 8.570 1.00 0.49 1SG
54 ATOM 54 CG LYS 7 26.045 78.697 8.611 1.00 0.49 1SG 55 ATOM 55 CD
LYS 7 26.398 77.211 8.617 1.00 0.49 1SG 56 ATOM 56 CE LYS 7 25.652
76.398 9.673 1.00 0.49 1SG 57 ATOM 57 NZ LYS 7 26.238 76.623 11.012
1.00 0.49 1SG 58 ATOM 58 C LYS 7 22.703 80.560 8.420 1.00 0.49 1SG
59 ATOM 59 O LYS 7 21.958 80.622 9.397 1.00 0.49 1SG 60 ATOM 60 N
ALA 8 22.243 80.568 7.155 1.00 0.29 1SG 61 ATOM 61 CA ALA 8 20.838
80.543 6.890 1.00 0.29 1SG 62 ATOM 62 CB ALA 8 20.483 80.789 5.413
1.00 0.29 1SG 63 ATOM 63 C ALA 8 20.394 79.162 7.254 1.00 0.29 1SG
64 ATOM 64 O ALA 8 21.215 78.248 7.328 1.00 0.29 1SG 65 ATOM 65 N
VAL 9 19.086 78.978 7.532 1.00 0.10 1SG 66 ATOM 66 CA VAL 9 18.614
77.679 7.929 1.00 0.10 1SG 67 ATOM 67 CB VAL 9 18.031 77.676 9.312
1.00 0.10 1SG 68 ATOM 68 CG1 VAL 9 17.521 76.263 9.638 1.00 0.10
1SG 69 ATOM 69 CG2 VAL 9 19.104 78.190 10.287 1.00 0.10 1SG 70 ATOM
70 C VAL 9 17.537 77.242 6.979 1.00 0.10 1SG 71 ATOM 71 O VAL 9
16.568 77.964 6.746 1.00 0.10 1SG 72 ATOM 72 N VAL 10 17.674 76.015
6.431 1.00 0.19 1SG 73 ATOM 73 CA VAL 10 16.740 75.508 5.463 1.00
0.19 1SG 74 ATOM 74 CB VAL 10 17.398 74.689 4.392 1.00 0.19 1SG 75
ATOM 75 CG1 VAL 10 16.311 74.126 3.461 1.00 0.19 1SG 76 ATOM 76 CG2
VAL 10 18.435 75.572 3.678 1.00 0.19 1SG 77 ATOM 77 C VAL 10 15.729
74.638 6.147 1.00 0.19 1SG 78 ATOM 78 O VAL 10 16.071 73.734 6.909
1.00 0.19 1SG 79 ATOM 79 N PHE 11 14.436 74.903 5.866 1.00 0.29 1SG
80 ATOM 80 CA PHE 11 13.341 74.203 6.478 1.00 0.29 1SG 81 ATOM 81
CB PHE 11 12.390 75.198 7.171 1.00 0.29 1SG 82 ATOM 82 CG PHE 11
11.324 74.489 7.929 1.00 0.29 1SG 83 ATOM 83 CD1 PHE 11 11.626
73.789 9.074 1.00 0.29 1SG 84 ATOM 84 CD2 PHE 11 10.016 74.560
7.515 1.00 0.29 1SG 85 ATOM 85 CE1 PHE 11 10.640 73.144 9.783 1.00
0.29 1SG 86 ATOM 86 CE2 PHE 11 9.030 73.918 8.223 1.00 0.29 1SG 87
ATOM 87 CZ PHE 11 9.337 73.205 9.357 1.00 0.29 1SG 88 ATOM 88 C PHE
11 12.610 73.473 5.386 1.00 0.29 1SG 89 ATOM 89 O PHE 11 12.366
74.029 4.317 1.00 0.29 1SG 90 ATOM 90 N LEU 12 12.252 72.194 5.639
1.00 0.22 1SG 91 ATOM 91 CA LEU 12 11.623 71.357 4.649 1.00 0.22
1SG 92 ATOM 92 CB LEU 12 12.417 70.050 4.443 1.00 0.22 1SG 93 ATOM
93 CG LEU 12 11.841 69.069 3.405 1.00 0.22 1SG 94 ATOM 94 CD2 LEU
12 12.543 67.702 3.485 1.00 0.22 1SG 95 ATOM 95 CD1 LEU 12 11.878
69.665 1.988 1.00 0.22 1SG 96 ATOM 96 C LEU 12 10.245 70.996 5.122
1.00 0.22 1SG 97 ATOM 97 O LEU 12 10.069 70.535 6.248 1.00 0.22 1SG
98 ATOM 98 N GLU 13 9.214 71.217 4.272 1.00 0.16 1SG 99 ATOM 99 CA
GLU 13 7.873 70.835 4.636 1.00 0.16 1SG 100 ATOM 100 CB GLU 13
6.922 72.012 4.907 1.00 0.16 1SG 101 ATOM 101 CG GLU 13 7.239
72.794 6.177 1.00 0.16 1SG 102 ATOM 102 CD GLU 13 6.214 73.912
6.297 1.00 0.16 1SG 103 ATOM 103 OE1 GLU 13 4.999 73.592 6.393 1.00
0.16 1SG 104 ATOM 104 OE2 GLU 13 6.630 75.102 6.291 1.00 0.16 1SG
105 ATOM 105 C GLU 13 7.271 70.102 3.478 1.00 0.16 1SG 106 ATOM 106
O GLU 13 7.330 70.573 2.342 1.00 0.16 1SG 107 ATOM 107 N PRO 14
6.706 68.948 3.714 1.00 0.21 1SG 108 ATOM 108 CA PRO 14 6.667
68.302 4.996 1.00 0.21 1SG 109 ATOM 109 CD PRO 14 5.925 68.248
2.709 1.00 0.21 1SG 110 ATOM 110 CB PRO 14 5.700 67.126 4.839 1.00
0.21 1SG 111 ATOM 111 CG PRO 14 5.667 66.862 3.323 1.00 0.21 1SG
112 ATOM 112 C PRO 14 8.071 67.870 5.287 1.00 0.21 1SG 113 ATOM 113
O PRO 14 8.917 67.964 4.402 1.00 0.21 1SG 114 ATOM 114 N GLN 15
8.326 67.394 6.518 1.00 0.25 1SG 115 ATOM 115 CA GLN 15 9.620
67.052 7.049 1.00 0.25 1SG 116 ATOM 116 CB GLN 15 9.550 66.690
8.541 1.00 0.25 1SG 117 ATOM 117 CG GLN 15 9.071 67.839 9.430 1.00
0.25 1SG 118 ATOM 118 CD GLN 15 9.049 67.340 10.867 1.00 0.25 1SG
119 ATOM 119 OE1 GLN 15 9.139 68.123 11.812 1.00 0.25 1SG 120 ATOM
120 NE2 GLN 15 8.927 65.996 11.040 1.00 0.25 1SG 121 ATOM 121 C GLN
15 10.263 65.875 6.364 1.00 0.25 1SG 122 ATOM 122 O GLN 15 11.479
65.714 6.432 1.00 0.25 1SG 123 ATOM 123 N TRP 16 9.473 64.991 5.735
1.00 0.44 1SG 124 ATOM 124 CA TRP 16 9.960 63.744 5.199 1.00 0.44
1SG 125 ATOM 125 CB TRP 16 8.870 63.023 4.396 1.00 0.44 1SG 126
ATOM 126 CG TRP 16 7.568 62.935 5.152 1.00 0.44 1SG 127 ATOM 127
CD2 TRP 16 7.393 62.263 6.408 1.00 0.44 1SG 128 ATOM 128 CD1 TRP 16
6.368 63.510 4.849 1.00 0.44 1SG 129 ATOM 129 NE1 TRP 16 5.454
63.236 5.837 1.00 0.44 1SG 130 ATOM 130 CE2 TRP 16 6.072 62.471
6.804 1.00 0.44 1SG 131 ATOM 131 CE3 TRP 16 8.263 61.541 7.173 1.00
0.44 1SG 132 ATOM 132 CZ2 TRP 16 5.599 61.956 7.976 1.00 0.44 1SG
133 ATOM 133 CZ3 TRP 16 7.780 61.016 8.351 1.00 0.44 1SG 134 ATOM
134 CH2 TRP 16 6.473 61.220 8.745 1.00 0.44 1SG 135 ATOM 135 C TRP
16 11.131 63.929 4.267 1.00 0.44 1SG 136 ATOM 136 O TRP 16 11.062
64.684 3.297 1.00 0.44 1SG 137 ATOM 137 N TYR 17 12.261 63.242
4.567 1.00 0.57 1SG 138 ATOM 138 CA TYR 17 13.440 63.252 3.737 1.00
0.57 1SG 139 ATOM 139 CB TYR 17 14.749 62.870 4.463 1.00 0.57 1SG
140 ATOM 140 CG TYR 17 14.639 61.516 5.071 1.00 0.57 1SG 141 ATOM
141 CD1 TYR 17 14.599 60.383 4.291 1.00 0.57 1SG 142 ATOM 142 CD2
TYR 17 14.616 61.383 6.440 1.00 0.57 1SG 143 ATOM 143 CE1 TYR 17
14.507 59.139 4.869 1.00 0.57 1SG 144 ATOM 144 CE2 TYR 17 14.524
60.142 7.024 1.00 0.57 1SG 145 ATOM 145 CZ TYR 17 14.465 59.017
6.237 1.00 0.57 1SG 146 ATOM 146 OH TYR 17 14.370 57.742 6.833 1.00
0.57 1SG 147 ATOM 147 C TYR 17 13.280 62.371 2.530 1.00 0.57 1SG
148 ATOM 148 O TYR 17 13.902 62.621 1.498 1.00 0.57 1SG 149 ATOM
149 N SER 18 12.494 61.278 2.632 1.00 0.33 1SG 150 ATOM 150 CA SER
18 12.317 60.414 1.493 1.00 0.33 1SG 151 ATOM 151 CB SER 18 12.454
58.918 1.826 1.00 0.33 1SG 152 ATOM 152 OG SER 18 11.412 58.518
2.704 1.00 0.33 1SG 153 ATOM 153 C SER 18 10.925 60.641 0.986 1.00
0.33 1SG 154 ATOM 154 O SER 18 9.960 60.479 1.730 1.00 0.33 1SG 155
ATOM 155 N VAL 19 10.783 61.019 -0.304 1.00 0.11 1SG 156 ATOM 156
CA VAL 19 9.477 61.311 -0.838 1.00 0.11 1SG 157 ATOM 157 CB VAL 19
9.269 62.761 -1.167 1.00 0.11 1SG 158 ATOM 158 CG1 VAL 19 9.380
63.581 0.130 1.00 0.11 1SG 159 ATOM 159 CG2 VAL 19 10.274 63.169
-2.257 1.00 0.11 1SG 160 ATOM 160 C VAL 19 9.271 60.547 -2.114 1.00
0.11 1SG 161 ATOM 161 O VAL 19 10.165 59.855 -2.599 1.00 0.11 1SG
162 ATOM 162 N LEU 20 8.048 60.648 -2.680 1.00 0.12 1SG 163 ATOM
163 CA LEU 20 7.707 59.953 -3.890 1.00 0.12 1SG 164 ATOM 164 CB LEU
20 6.371 59.199 -3.799 1.00 0.12 1SG 165 ATOM 165 CG LEU 20 6.393
58.029 -2.795 1.00 0.12 1SG 166 ATOM 166 CD2 LEU 20 7.551 57.064
-3.096 1.00 0.12 1SG 167 ATOM 167 CD1 LEU 20 5.036 57.311 -2.743
1.00 0.12 1SG 168 ATOM 168 C LEU 20 7.584 60.945 -5.006 1.00 0.12
1SG 169 ATOM 169 O LEU 20 7.318 62.129 -4.797 1.00 0.12 1SG 170
ATOM 170 N GLU 21 7.793 60.471 -6.250 1.00 0.27 1SG 171 ATOM 171 CA
GLU 21 7.682 61.341 -7.379 1.00 0.27 1SG 172 ATOM 172 CB GLU 21
7.866 60.617 -8.725 1.00 0.27 1SG 173 ATOM 173 CG GLU 21 9.271
60.049 -8.935 1.00 0.27 1SG 174 ATOM 174 CD GLU 21 9.297 59.370
-10.297 1.00 0.27 1SG 175 ATOM 175 OE1 GLU 21 8.246 59.409 -10.992
1.00 0.27 1SG 176 ATOM 176 OE2 GLU 21 10.363 58.805 -10.660 1.00
0.27 1SG 177 ATOM 177 C GLU 21 6.305 61.919 -7.359 1.00 0.27 1SG
178 ATOM 178 O GLU 21 5.336 61.251 -7.002 1.00 0.27 1SG 179 ATOM
179 N LYS 22 6.206 63.202 -7.752 1.00 0.41 1SG 180 ATOM 180 CA LYS
22 4.977 63.941 -7.839 1.00 0.41 1SG 181 ATOM 181 CB LYS 22 3.802
63.104 -8.379 1.00 0.41 1SG 182 ATOM 182 CG LYS 22 2.521 63.919
-8.568 1.00 0.41 1SG 183 ATOM 183 CD LYS 22 1.471 63.227 -9.442
1.00 0.41 1SG 184 ATOM 184 CE LYS 22 1.782 63.301 -10.939 1.00 0.41
1SG 185 ATOM 185 NZ LYS 22 0.726 62.610 -11.713 1.00 0.41 1SG 186
ATOM 186 C LYS 22 4.576 64.522 -6.511 1.00 0.41 1SG 187 ATOM 187 O
LYS 22 3.617 65.290 -6.454 1.00 0.41 1SG 188 ATOM 188 N ASP 23
5.298 64.220 -5.413 1.00 0.26 1SG 189 ATOM 189 CA ASP 23 4.948
64.822 -4.152 1.00 0.26 1SG 190 ATOM 190 CB ASP 23 5.586 64.148
-2.921 1.00 0.26 1SG 191 ATOM 191 CG ASP 23 4.923 62.800 -2.666
1.00 0.26 1SG 192 ATOM 192 OD1 ASP 23 3.763 62.602 -3.117 1.00 0.26
1SG 193 ATOM 193 OD2 ASP 23 5.574 61.949 -2.004 1.00 0.26 1SG 194
ATOM 194 C ASP 23 5.437 66.242 -4.163 1.00 0.26 1SG 195 ATOM 195 O
ASP 23 6.388 66.584 -4.872 1.00 0.26 1SG 196 ATOM 196 N SER 24
4.784 67.104 -3.350 1.00 0.11 1SG 197 ATOM 197 CA SER 24 5.124
68.497 -3.284 1.00 0.11 1SG 198 ATOM 198 CB SER 24 3.932 69.399
-2.918 1.00 0.11 1SG 199 ATOM 199 OG SER 24 4.336 70.760 -2.873
1.00 0.11 1SG 200 ATOM 200 C SER 24 6.159 68.680 -2.222 1.00 0.11
1SG 201 ATOM 201 O SER 24 6.104 68.045 -1.171 1.00 0.11 1SG 202
ATOM 202 N VAL 25 7.164 69.537 -2.487 1.00 0.10 1SG 203 ATOM 203 CA
VAL 25 8.167 69.792 -1.492 1.00 0.10 1SG 204 ATOM 204 CB VAL 25
9.530 69.287 -1.877 1.00 0.10 1SG 205 ATOM 205 CG1 VAL 25 10.534
69.704 -0.789 1.00 0.10 1SG 206 ATOM 206 CG2 VAL 25 9.453 67.767
-2.104 1.00 0.10 1SG 207 ATOM 207 C VAL 25 8.278 71.276 -1.344 1.00
0.10 1SG 208 ATOM 208 O VAL 25 8.336 71.999 -2.338 1.00 0.10 1SG
209 ATOM 209 N THR 26 8.295 71.766 -0.084 1.00 0.09 1SG 210 ATOM
210 CA THR 26 8.408 73.177 0.164 1.00 0.09 1SG 211 ATOM 211 CB THR
26 7.254 73.732 0.946 1.00 0.09 1SG 212 ATOM 212 OG1 THR 26 6.040
73.502 0.247 1.00 0.09 1SG 213 ATOM 213 CG2 THR 26 7.467 75.243
1.142 1.00 0.09 1SG 214 ATOM 214 C THR 26 9.640 73.398 0.982 1.00
0.09 1SG 215 ATOM 215 O THR 26 9.791 72.851 2.073 1.00 0.09 1SG 216
ATOM 216 N LEU 27 10.568 74.219 0.461 1.00 0.16 1SG 217 ATOM 217 CA
LEU 27 11.777 74.529 1.162 1.00 0.16 1SG 218 ATOM 218 CB LEU 27
13.031 74.380 0.286 1.00 0.16 1SG 219 ATOM 219 CG LEU 27 13.325
72.930 -0.140 1.00 0.16 1SG 220 ATOM 220 CD2 LEU 27 13.423 72.008
1.081 1.00 0.16 1SG 221 ATOM 221 CD1 LEU 27 14.585 72.854 -1.013
1.00 0.16 1SG 222 ATOM 222 C LEU 27 11.683 75.974 1.550 1.00 0.16
1SG 223 ATOM 223 O LEU 27 11.267 76.812 0.752 1.00 0.16 1SG 224
ATOM 224 N LYS 28 12.051 76.300 2.806 1.00 0.26 1SG 225 ATOM 225 CA
LYS 28 11.982 77.664 3.253 1.00 0.26 1SG 226 ATOM 226 CB LYS 28
11.025 77.848 4.443 1.00 0.26 1SG 227 ATOM 227 CG LYS 28 9.559
77.562 4.112 1.00 0.26 1SG 228 ATOM 228 CD LYS 28 8.696 77.332
5.355 1.00 0.26 1SG 229 ATOM 229 CE LYS 28 8.759 78.477 6.369 1.00
0.26 1SG 230 ATOM 230 NZ LYS 28 7.898 78.171 7.534 1.00 0.26 1SG
231 ATOM 231 C LYS 28 13.350 78.065 3.716 1.00 0.26 1SG 232 ATOM
232 O LYS 28 13.972 77.361 4.510 1.00 0.26 1SG 233 ATOM 233 N CYS
29 13.855 79.221 3.231 1.00 0.25 1SG 234 ATOM 234 CA CYS 29 15.166
79.665 3.623 1.00 0.25 1SG 235 ATOM 235 CB CYS 29 15.989 80.261
2.466 1.00 0.25 1SG 236 ATOM 236 SG CYS 29 17.746 80.487 2.876 1.00
0.25 1SG 237 ATOM 237 C CYS 29 14.976 80.743 4.635 1.00 0.25 1SG
238 ATOM 238 O CYS 29 14.520 81.842 4.318 1.00 0.25 1SG 239 ATOM
239 N GLN 30 15.362 80.444 5.888 1.00 0.20 1SG 240 ATOM 240 CA GLN
30 15.150 81.352 6.974 1.00 0.20 1SG 241 ATOM 241 CB GLN 30 14.662
80.641 8.250 1.00 0.20 1SG 242 ATOM 242 CG GLN 30 13.328 79.910
8.073 1.00 0.20 1SG 243 ATOM 243 CD GLN 30 12.990 79.231 9.393 1.00
0.20 1SG 244 ATOM 244 OE1 GLN 30 13.436 79.665 10.454 1.00 0.20 1SG
245 ATOM 245 NE2 GLN 30 12.190 78.133 9.331 1.00 0.20 1SG 246 ATOM
246 C GLN 30 16.447 82.021 7.307 1.00 0.20 1SG 247 ATOM 247 O GLN
30 17.516 81.416 7.227 1.00 0.20 1SG 248 ATOM 248 N GLY 31 16.370
83.318 7.670 1.00 0.17 1SG 249 ATOM 249 CA GLY 31 17.534 84.063
8.057 1.00 0.17 1SG 250 ATOM 250 C GLY 31 17.314 85.486 7.647 1.00
0.17 1SG 251 ATOM 251 O GLY 31 16.372 85.790 6.917 1.00 0.17 1SG
252 ATOM 252 N ALA 32 18.204 86.394 8.100 1.00 0.26 1SG 253 ATOM
253 CA ALA 32 18.069 87.786 7.779 1.00 0.26 1SG 254 ATOM 254 CB ALA
32 19.036 88.698 8.555 1.00 0.26 1SG 255 ATOM 255 C ALA 32 18.361
87.941 6.323 1.00 0.26 1SG 256 ATOM 256 O ALA 32 19.239 87.270
5.783 1.00 0.26 1SG 257 ATOM 257 N TYR 33 17.622 88.851 5.656 1.00
0.37 1SG 258 ATOM 258 CA TYR 33 17.742 89.029 4.237 1.00 0.37 1SG
259 ATOM 259 CB TYR 33 16.403 88.888 3.494 1.00 0.37 1SG 260 ATOM
260 CG TYR 33 15.701 87.652 3.939 1.00 0.37 1SG 261 ATOM 261 CD1
TYR 33 16.014 86.413 3.431 1.00 0.37 1SG 262 ATOM 262 CD2 TYR 33
14.701 87.754 4.878 1.00 0.37 1SG 263 ATOM 263 CE1 TYR 33 15.336
85.295 3.863 1.00 0.37 1SG 264 ATOM 264 CE2 TYR 33 14.020 86.642
5.313 1.00 0.37 1SG 265 ATOM 265 CZ TYR 33 14.340 85.408 4.804 1.00
0.37 1SG 266 ATOM 266 OH TYR 33 13.646 84.261 5.243 1.00 0.37 1SG
267 ATOM 267 C TYR 33 18.105 90.462 3.998 1.00 0.37 1SG 268 ATOM
268 O TYR 33 18.011 91.297 4.896 1.00 0.37 1SG 269 ATOM 269 N SER
34 18.565 90.773 2.768 1.00 0.30 1SG 270 ATOM 270 CA SER 34 18.837
92.136 2.411 1.00 0.30 1SG 271 ATOM 271 CB SER 34 19.977 92.293
1.390 1.00 0.30 1SG 272 ATOM 272 OG SER 34 21.202 91.842 1.949 1.00
0.30 1SG 273 ATOM 273 C SER 34 17.592 92.664 1.776 1.00 0.30 1SG
274 ATOM 274 O SER 34 16.777 91.896 1.264 1.00 0.30 1SG 275 ATOM
275 N PRO 35 17.383 93.950 1.821 1.00 0.24 1SG 276 ATOM 276 CA PRO
35 16.224 94.476 1.167 1.00 0.24 1SG 277 ATOM 277 CD PRO 35 17.816
94.788 2.923 1.00 0.24 1SG 278 ATOM 278 CB PRO 35 16.024 95.891
1.717 1.00 0.24 1SG 279 ATOM 279 CG PRO 35 17.306 96.182 2.527 1.00
0.24 1SG 280 ATOM 280 C PRO 35 16.414 94.377 -0.309 1.00 0.24 1SG
281 ATOM 281 O PRO 35 17.086 95.235 -0.882 1.00 0.24 1SG 282 ATOM
282 N GLU 36 15.796 93.358 -0.938 1.00 0.28 1SG 283 ATOM 283 CA GLU
36 15.884 93.180 -2.356 1.00 0.28 1SG 284 ATOM 284 CB GLU 36 17.245
92.670 -2.865 1.00 0.28 1SG 285 ATOM 285 CG GLU 36 17.579
91.245 -2.422 1.00 0.28 1SG 286 ATOM 286 CD GLU 36 18.911 90.862
-3.049 1.00 0.28 1SG 287 ATOM 287 OE1 GLU 36 18.954 90.706 -4.299
1.00 0.28 1SG 288 ATOM 288 OE2 GLU 36 19.906 90.723 -2.288 1.00
0.28 1SG 289 ATOM 289 C GLU 36 14.878 92.137 -2.725 1.00 0.28 1SG
290 ATOM 290 O GLU 36 14.517 91.286 -1.912 1.00 0.28 1SG 291 ATOM
291 N ASP 37 14.393 92.191 -3.978 1.00 0.30 1SG 292 ATOM 292 CA ASP
37 13.415 91.251 -4.436 1.00 0.30 1SG 293 ATOM 293 CB ASP 37 12.885
91.582 -5.842 1.00 0.30 1SG 294 ATOM 294 CG ASP 37 11.706 90.667
-6.145 1.00 0.30 1SG 295 ATOM 295 OD1 ASP 37 11.405 89.773 -5.310
1.00 0.30 1SG 296 ATOM 296 OD2 ASP 37 11.086 90.853 -7.226 1.00
0.30 1SG 297 ATOM 297 C ASP 37 14.020 89.882 -4.499 1.00 0.30 1SG
298 ATOM 298 O ASP 37 13.423 88.916 -4.026 1.00 0.30 1SG 299 ATOM
299 N ASN 38 15.227 89.754 -5.088 1.00 0.32 1SG 300 ATOM 300 CA ASN
38 15.808 88.444 -5.198 1.00 0.32 1SG 301 ATOM 301 CB ASN 38 16.651
88.257 -6.472 1.00 0.32 1SG 302 ATOM 302 CG ASN 38 15.715 88.249
-7.675 1.00 0.32 1SG 303 ATOM 303 OD1 ASN 38 14.501 88.106 -7.540
1.00 0.32 1SG 304 ATOM 304 ND2 ASN 38 16.300 88.393 -8.894 1.00
0.32 1SG 305 ATOM 305 C ASN 38 16.722 88.253 -4.028 1.00 0.32 1SG
306 ATOM 306 O ASN 38 17.941 88.343 -4.157 1.00 0.32 1SG 307 ATOM
307 N SER 39 16.129 87.978 -2.851 1.00 0.48 1SG 308 ATOM 308 CA SER
39 16.810 87.823 -1.597 1.00 0.48 1SG 309 ATOM 309 CB SER 39 15.861
87.925 -0.392 1.00 0.48 1SG 310 ATOM 310 OG SER 39 15.314 89.231
-0.308 1.00 0.48 1SG 311 ATOM 311 C SER 39 17.535 86.510 -1.448
1.00 0.48 1SG 312 ATOM 312 O SER 39 18.534 86.442 -0.737 1.00 0.48
1SG 313 ATOM 313 N THR 40 17.061 85.405 -2.055 1.00 0.54 1SG 314
ATOM 314 CA THR 40 17.721 84.170 -1.709 1.00 0.54 1SG 315 ATOM 315
CB THR 40 16.821 83.202 -0.997 1.00 0.54 1SG 316 ATOM 316 OG1 THR
40 15.745 82.821 -1.841 1.00 0.54 1SG 317 ATOM 317 CG2 THR 40
16.283 83.878 0.276 1.00 0.54 1SG 318 ATOM 318 C THR 40 18.276
83.447 -2.899 1.00 0.54 1SG 319 ATOM 319 O THR 40 17.733 83.482
-4.001 1.00 0.54 1SG 320 ATOM 320 N GLN 41 19.415 82.757 -2.678
1.00 0.31 1SG 321 ATOM 321 CA GLN 41 20.021 81.948 -3.694 1.00 0.31
1SG 322 ATOM 322 CB GLN 41 21.552 82.067 -3.738 1.00 0.31 1SG 323
ATOM 323 CG GLN 41 22.071 83.453 -4.118 1.00 0.31 1SG 324 ATOM 324
CD GLN 41 23.581 83.418 -3.944 1.00 0.31 1SG 325 ATOM 325 OE1 GLN
41 24.283 84.384 -4.235 1.00 0.31 1SG 326 ATOM 326 NE2 GLN 41
24.101 82.266 -3.443 1.00 0.31 1SG 327 ATOM 327 C GLN 41 19.738
80.532 -3.297 1.00 0.31 1SG 328 ATOM 328 O GLN 41 19.972 80.153
-2.150 1.00 0.31 1SG 329 ATOM 329 N TRP 42 19.207 79.715 -4.229
1.00 0.13 1SG 330 ATOM 330 CA TRP 42 18.948 78.336 -3.910 1.00 0.13
1SG 331 ATOM 331 CB TRP 42 17.531 77.840 -4.248 1.00 0.13 1SG 332
ATOM 332 CG TRP 42 16.469 78.313 -3.291 1.00 0.13 1SG 333 ATOM 333
CD2 TRP 42 16.139 77.634 -2.069 1.00 0.13 1SG 334 ATOM 334 CD1 TRP
42 15.660 79.406 -3.359 1.00 0.13 1SG 335 ATOM 335 NE1 TRP 42
14.849 79.450 -2.253 1.00 0.13 1SG 336 ATOM 336 CE2 TRP 42 15.130
78.368 -1.451 1.00 0.13 1SG 337 ATOM 337 CE3 TRP 42 16.638 76.495
-1.506 1.00 0.13 1SG 338 ATOM 338 CZ2 TRP 42 14.601 77.977 -0.255
1.00 0.13 1SG 339 ATOM 339 CZ3 TRP 42 16.101 76.100 -0.301 1.00
0.13 1SG 340 ATOM 340 CH2 TRP 42 15.101 76.827 0.312 1.00 0.13 1SG
341 ATOM 341 C TRP 42 19.895 77.498 -4.701 1.00 0.13 1SG 342 ATOM
342 O TRP 42 20.228 77.832 -5.836 1.00 0.13 1SG 343 ATOM 343 N PHE
43 20.367 76.385 -4.099 1.00 0.11 1SG 344 ATOM 344 CA PHE 43 21.302
75.544 -4.787 1.00 0.11 1SG 345 ATOM 345 CB PHE 43 22.711 75.557
-4.166 1.00 0.11 1SG 346 ATOM 346 CG PHE 43 23.295 76.925 -4.278
1.00 0.11 1SG 347 ATOM 347 CD1 PHE 43 23.030 77.879 -3.322 1.00
0.11 1SG 348 ATOM 348 CD2 PHE 43 24.113 77.251 -5.335 1.00 0.11 1SG
349 ATOM 349 CE1 PHE 43 23.572 79.139 -3.421 1.00 0.11 1SG 350 ATOM
350 CE2 PHE 43 24.658 78.510 -5.440 1.00 0.11 1SG 351 ATOM 351 CZ
PHE 43 24.386 79.457 -4.482 1.00 0.11 1SG 352 ATOM 352 C PHE 43
20.843 74.120 -4.693 1.00 0.11 1SG 353 ATOM 353 O PHE 43 20.285
73.695 -3.682 1.00 0.11 1SG 354 ATOM 354 N HIS 44 21.065 73.353
-5.782 1.00 0.13 1SG 355 ATOM 355 CA HIS 44 20.777 71.948 -5.815
1.00 0.13 1SG 356 ATOM 356 ND1 HIS 44 18.580 69.494 -7.813 1.00
0.13 1SG 357 ATOM 357 CG HIS 44 19.360 70.111 -6.859 1.00 0.13 1SG
358 ATOM 358 CB HIS 44 19.757 71.560 -6.902 1.00 0.13 1SG 359 ATOM
359 NE2 HIS 44 19.059 67.948 -6.288 1.00 0.13 1SG 360 ATOM 360 CD2
HIS 44 19.643 69.152 -5.935 1.00 0.13 1SG 361 ATOM 361 CE1 HIS 44
18.432 68.203 -7.422 1.00 0.13 1SG 362 ATOM 362 C HIS 44 22.070
71.286 -6.166 1.00 0.13 1SG 363 ATOM 363 O HIS 44 22.582 71.465
-7.270 1.00 0.13 1SG 364 ATOM 364 N ASN 45 22.633 70.494 -5.234
1.00 0.21 1SG 365 ATOM 365 CA ASN 45 23.888 69.850 -5.489 1.00 0.21
1SG 366 ATOM 366 CB ASN 45 23.811 68.784 -6.595 1.00 0.21 1SG 367
ATOM 367 CG ASN 45 23.006 67.606 -6.063 1.00 0.21 1SG 368 ATOM 368
OD1 ASN 45 22.804 67.465 -4.857 1.00 0.21 1SG 369 ATOM 369 ND2 ASN
45 22.542 66.723 -6.987 1.00 0.21 1SG 370 ATOM 370 C ASN 45 24.885
70.895 -5.896 1.00 0.21 1SG 371 ATOM 371 O ASN 45 25.698 70.672
-6.792 1.00 0.21 1SG 372 ATOM 372 N GLU 46 24.851 72.063 -5.223
1.00 0.25 1SG 373 ATOM 373 CA GLU 46 25.781 73.134 -5.465 1.00 0.25
1SG 374 ATOM 374 CB GLU 46 27.239 72.652 -5.580 1.00 0.25 1SG 375
ATOM 375 CG GLU 46 27.885 72.278 -4.245 1.00 0.25 1SG 376 ATOM 376
CD GLU 46 28.429 73.558 -3.621 1.00 0.25 1SG 377 ATOM 377 OE1 GLU
46 28.277 74.634 -4.260 1.00 0.25 1SG 378 ATOM 378 OE2 GLU 46
29.006 73.479 -2.503 1.00 0.25 1SG 379 ATOM 379 C GLU 46 25.473
73.880 -6.731 1.00 0.25 1SG 380 ATOM 380 O GLU 46 26.222 74.785
-7.095 1.00 0.25 1SG 381 ATOM 381 N SER 47 24.364 73.575 -7.430
1.00 0.17 1SG 382 ATOM 382 CA SER 47 24.095 74.317 -8.633 1.00 0.17
1SG 383 ATOM 383 CB SER 47 23.621 73.440 -9.806 1.00 0.17 1SG 384
ATOM 384 OG SER 47 24.655 72.553 -10.206 1.00 0.17 1SG 385 ATOM 385
C SER 47 22.995 75.284 -8.328 1.00 0.17 1SG 386 ATOM 386 O SER 47
21.985 74.922 -7.728 1.00 0.17 1SG 387 ATOM 387 N LEU 48 23.167
76.556 -8.743 1.00 0.23 1SG 388 ATOM 388 CA LEU 48 22.186 77.559
-8.441 1.00 0.23 1SG 389 ATOM 389 CB LEU 48 22.626 78.993 -8.790
1.00 0.23 1SG 390 ATOM 390 CG LEU 48 21.562 80.060 -8.465 1.00 0.23
1SG 391 ATOM 391 CD2 LEU 48 21.917 81.419 -9.089 1.00 0.23 1SG 392
ATOM 392 CD1 LEU 48 21.311 80.151 -6.951 1.00 0.23 1SG 393 ATOM 393
C LEU 48 20.947 77.283 -9.227 1.00 0.23 1SG 394 ATOM 394 O LEU 48
21.009 76.888 -10.389 1.00 0.23 1SG 395 ATOM 395 N ILE 49 19.775
77.464 -8.584 1.00 0.46 1SG 396 ATOM 396 CA ILE 49 18.531 77.323
-9.283 1.00 0.46 1SG 397 ATOM 397 CB ILE 49 17.549 76.400 -8.612
1.00 0.46 1SG 398 ATOM 398 CG2 ILE 49 18.080 74.962 -8.702 1.00
0.46 1SG 399 ATOM 399 CG1 ILE 49 17.241 76.864 -7.186 1.00 0.46 1SG
400 ATOM 400 CD1 ILE 49 16.161 76.019 -6.512 1.00 0.46 1SG 401 ATOM
401 C ILE 49 17.942 78.697 -9.391 1.00 0.46 1SG 402 ATOM 402 O ILE
49 17.639 79.357 -8.403 1.00 0.46 1SG 403 ATOM 403 N SER 50 17.764
79.156 -10.636 1.00 0.56 1SG 404 ATOM 404 CA SER 50 17.325 80.482
-10.966 1.00 0.56 1SG 405 ATOM 405 CB SER 50 17.505 80.793 -12.460
1.00 0.56 1SG 406 ATOM 406 OG SER 50 18.882 80.738 -12.803 1.00
0.56 1SG 407 ATOM 407 C SER 50 15.878 80.719 -10.618 1.00 0.56 1SG
408 ATOM 408 O SER 50 15.446 81.866 -10.519 1.00 0.56 1SG 409 ATOM
409 N SER 51 15.082 79.649 -10.449 1.00 0.61 1SG 410 ATOM 410 CA
SER 51 13.649 79.730 -10.325 1.00 0.61 1SG 411 ATOM 411 CB SER 51
13.004 78.340 -10.202 1.00 0.61 1SG 412 ATOM 412 OG SER 51 13.266
77.580 -11.372 1.00 0.61 1SG 413 ATOM 413 C SER 51 13.097 80.566
-9.184 1.00 0.61 1SG 414 ATOM 414 O SER 51 12.185 81.348 -9.451
1.00 0.61 1SG 415 ATOM 415 N GLN 52 13.569 80.481 -7.907 1.00 0.62
1SG 416 ATOM 416 CA GLN 52 12.750 81.193 -6.937 1.00 0.62 1SG 417
ATOM 417 CB GLN 52 11.586 80.313 -6.439 1.00 0.62 1SG 418 ATOM 418
CG GLN 52 10.443 81.071 -5.758 1.00 0.62 1SG 419 ATOM 419 CD GLN 52
9.317 80.075 -5.510 1.00 0.62 1SG 420 ATOM 420 OE1 GLN 52 9.529
78.864 -5.547 1.00 0.62 1SG 421 ATOM 421 NE2 GLN 52 8.086 80.594
-5.258 1.00 0.62 1SG 422 ATOM 422 C GLN 52 13.480 81.759 -5.707
1.00 0.62 1SG 423 ATOM 423 O GLN 52 14.681 81.533 -5.549 1.00 0.62
1SG 424 ATOM 424 N ALA 53 12.693 82.502 -4.835 1.00 0.57 1SG 425
ATOM 425 CA ALA 53 12.863 83.308 -3.621 1.00 0.57 1SG 426 ATOM 426
CB ALA 53 11.846 84.457 -3.520 1.00 0.57 1SG 427 ATOM 427 C ALA 53
12.782 82.536 -2.306 1.00 0.57 1SG 428 ATOM 428 O ALA 53 13.156
81.373 -2.235 1.00 0.57 1SG 429 ATOM 429 N SER 54 12.284 83.191
-1.212 1.00 0.58 1SG 430 ATOM 430 CA SER 54 12.293 82.741 0.175
1.00 0.58 1SG 431 ATOM 431 CB SER 54 11.521 83.693 1.105 1.00 0.58
1SG 432 ATOM 432 OG SER 54 12.131 84.975 1.114 1.00 0.58 1SG 433
ATOM 433 C SER 54 11.680 81.388 0.356 1.00 0.58 1SG 434 ATOM 434 O
SER 54 12.214 80.553 1.090 1.00 0.58 1SG 435 ATOM 435 N SER 55
10.517 81.132 -0.255 1.00 0.46 1SG 436 ATOM 436 CA SER 55 9.984
79.811 -0.133 1.00 0.46 1SG 437 ATOM 437 CB SER 55 8.524 79.757
0.347 1.00 0.46 1SG 438 ATOM 438 OG SER 55 7.666 80.343 -0.618 1.00
0.46 1SG 439 ATOM 439 C SER 55 10.047 79.255 -1.508 1.00 0.46 1SG
440 ATOM 440 O SER 55 9.761 79.953 -2.479 1.00 0.46 1SG 441 ATOM
441 N TYR 56 10.485 77.992 -1.622 1.00 0.43 1SG 442 ATOM 442 CA TYR
56 10.595 77.372 -2.903 1.00 0.43 1SG 443 ATOM 443 CB TYR 56 12.067
77.058 -3.232 1.00 0.43 1SG 444 ATOM 444 CG TYR 56 12.177 76.276
-4.492 1.00 0.43 1SG 445 ATOM 445 CD1 TYR 56 11.797 76.812 -5.701
1.00 0.43 1SG 446 ATOM 446 CD2 TYR 56 12.710 75.010 -4.460 1.00
0.43 1SG 447 ATOM 447 CE1 TYR 56 11.919 76.076 -6.857 1.00 0.43 1SG
448 ATOM 448 CE2 TYR 56 12.836 74.270 -5.612 1.00 0.43 1SG 449 ATOM
449 CZ TYR 56 12.436 74.803 -6.814 1.00 0.43 1SG 450 ATOM 450 OH
TYR 56 12.563 74.048 -8.000 1.00 0.43 1SG 451 ATOM 451 C TYR 56
9.801 76.113 -2.812 1.00 0.43 1SG 452 ATOM 452 O TYR 56 10.155
75.196 -2.074 1.00 0.43 1SG 453 ATOM 453 N PHE 57 8.684 76.046
-3.561 1.00 0.62 1SG 454 ATOM 454 CA PHE 57 7.847 74.888 -3.487
1.00 0.62 1SG 455 ATOM 455 CB PHE 57 6.421 75.206 -2.996 1.00 0.62
1SG 456 ATOM 456 CG PHE 57 5.802 76.189 -3.932 1.00 0.62 1SG 457
ATOM 457 CD1 PHE 57 5.086 75.764 -5.028 1.00 0.62 1SG 458 ATOM 458
CD2 PHE 57 5.937 77.540 -3.710 1.00 0.62 1SG 459 ATOM 459 CE1 PHE
57 4.514 76.671 -5.889 1.00 0.62 1SG 460 ATOM 460 CE2 PHE 57 5.368
78.452 -4.567 1.00 0.62 1SG 461 ATOM 461 CZ PHE 57 4.655 78.018
-5.659 1.00 0.62 1SG 462 ATOM 462 C PHE 57 7.760 74.286 -4.844 1.00
0.62 1SG 463 ATOM 463 O PHE 57 7.588 74.986 -5.840 1.00 0.62 1SG
464 ATOM 464 N ILE 58 7.914 72.952 -4.921 1.00 0.54 1SG 465 ATOM
465 CA ILE 58 7.807 72.349 -6.209 1.00 0.54 1SG 466 ATOM 466 CB ILE
58 9.127 72.238 -6.929 1.00 0.54 1SG 467 ATOM 467 CG2 ILE 58 9.613
73.672 -7.192 1.00 0.54 1SG 468 ATOM 468 CG1 ILE 58 10.148 71.373
-6.163 1.00 0.54 1SG 469 ATOM 469 CD1 ILE 58 9.908 69.865 -6.239
1.00 0.54 1SG 470 ATOM 470 C ILE 58 7.196 70.999 -6.075 1.00 0.54
1SG 471 ATOM 471 O ILE 58 7.445 70.281 -5.109 1.00 0.54 1SG 472
ATOM 472 N ASP 59 6.318 70.643 -7.038 1.00 0.34 1SG 473 ATOM 473 CA
ASP 59 5.869 69.286 -7.121 1.00 0.34 1SG 474 ATOM 474 CB ASP 59
4.410 69.150 -7.587 1.00 0.34 1SG 475 ATOM 475 CG ASP 59 3.516
69.675 -6.473 1.00 0.34 1SG 476 ATOM 476 OD1 ASP 59 4.061 70.282
-5.514 1.00 0.34 1SG 477 ATOM 477 OD2 ASP 59 2.277 69.465 -6.562
1.00 0.34 1SG 478 ATOM 478 C ASP 59 6.741 68.771 -8.189 1.00 0.34
1SG 479 ATOM 479 O ASP 59 6.411 67.882 -8.972 1.00 0.34 1SG 480
ATOM 480 N ALA 60 7.950 69.337 -8.208 1.00 0.27 1SG 481 ATOM 481 CA
ALA 60 8.903 68.892 -9.141 1.00 0.27 1SG 482 ATOM 482 CB ALA 60
9.978 69.945 -9.459 1.00 0.27 1SG 483 ATOM 483 C ALA 60 9.569
67.769 -8.452 1.00 0.27 1SG 484 ATOM 484 O ALA 60 10.713 67.472
-8.784 1.00 0.27 1SG 485 ATOM 485 N ALA 61 8.892 67.133 -7.457 1.00
0.37 1SG 486 ATOM 486 CA ALA 61 9.565 66.004 -6.941 1.00 0.37 1SG
487 ATOM 487 CB ALA 61 8.825 65.293 -5.796 1.00 0.37 1SG 488 ATOM
488 C ALA 61 9.623 65.065 -8.099 1.00 0.37 1SG 489 ATOM 489 O ALA
61 8.603 64.547 -8.550 1.00 0.37 1SG 490 ATOM 490 N THR 62 10.842
64.876 -8.632 1.00 0.56 1SG 491 ATOM 491 CA THR 62 11.083 64.025
-9.750 1.00 0.56 1SG 492 ATOM 492 CB THR 62 11.287 64.754 -11.044
1.00 0.56 1SG 493 ATOM 493 OG1 THR 62 12.411 65.617 -10.953 1.00
0.56 1SG 494 ATOM 494 CG2 THR 62 10.016 65.559 -11.364 1.00 0.56
1SG 495 ATOM 495 C THR 62 12.357 63.334 -9.425 1.00 0.56 1SG 496
ATOM 496 O THR 62 13.021 63.674 -8.449 1.00 0.56 1SG 497 ATOM 497 N
VAL 63 12.743 62.358 -10.258 1.00 0.52 1SG 498 ATOM 498 CA VAL 63
13.904 61.569 -9.983 1.00 0.52 1SG 499 ATOM 499 CB VAL 63 14.189
60.580 -11.080 1.00 0.52 1SG 500 ATOM 500 CG1 VAL 63 13.009 59.597
-11.163 1.00 0.52 1SG 501 ATOM 501 CG2 VAL 63 14.445 61.338 -12.394
1.00 0.52 1SG 502 ATOM 502 C VAL 63 15.086 62.480 -9.863 1.00 0.52
1SG 503 ATOM 503 O VAL 63 15.924 62.309 -8.980 1.00 0.52 1SG 504
ATOM 504 N ASN 64 15.146 63.505 -10.731 1.00 0.32 1SG 505 ATOM 505
CA ASN 64 16.248 64.419 -10.842 1.00 0.32 1SG 506 ATOM 506 CB ASN
64 16.078 65.400 -12.013 1.00 0.32 1SG 507 ATOM 507 CG ASN 64
16.191 64.599 -13.303 1.00 0.32 1SG 508 ATOM 508 OD1 ASN 64 15.323
63.792 -13.630 1.00 0.32 1SG 509 ATOM 509 ND2 ASN 64 17.296 64.827
-14.062 1.00 0.32 1SG 510 ATOM 510 C ASN 64 16.425 65.225 -9.588
1.00 0.32 1SG 511 ATOM 511 O ASN 64 17.531 65.680 -9.305 1.00 0.32
1SG 512 ATOM 512 N ASP 65 15.338 65.442 -8.825 1.00 0.25 1SG 513
ATOM 513 CA ASP 65 15.318 66.284 -7.655 1.00 0.25 1SG 514 ATOM 514
CB ASP 65 13.909 66.571 -7.117 1.00 0.25 1SG 515 ATOM 515 CG ASP 65
13.324 67.671 -7.985 1.00 0.25 1SG 516 ATOM 516 OD1 ASP 65 13.629
67.694 -9.207 1.00 0.25 1SG 517 ATOM 517 OD2 ASP 65 12.581 68.522
-7.428 1.00 0.25 1SG 518 ATOM 518 C ASP 65 16.143 65.782 -6.505
1.00 0.25 1SG 519 ATOM 519 O ASP 65 16.459 66.561 -5.609 1.00 0.25
1SG 520 ATOM 520 N SER 66 16.465 64.481 -6.423 1.00 0.26 1SG 521
ATOM 521 CA SER 66 17.211 64.032 -5.275 1.00 0.26 1SG 522 ATOM 522
CB SER 66 17.558 62.533 -5.309 1.00 0.26 1SG 523 ATOM 523 OG SER 66
16.372 61.755 -5.255 1.00 0.26 1SG 524 ATOM 524 C SER 66 18.509
64.781 -5.185 1.00 0.26 1SG 525 ATOM 525 O SER 66 19.017 65.300
-6.177 1.00 0.26 1SG 526 ATOM 526 N GLY 67 19.071 64.884 -3.958
1.00 0.35 1SG 527 ATOM 527 CA GLY 67 20.340 65.543 -3.821 1.00 0.35
1SG 528 ATOM 528 C GLY 67 20.318 66.412 -2.603 1.00 0.35 1SG 529
ATOM 529 O GLY 67 19.423 66.318 -1.765 1.00 0.35 1SG 530 ATOM 530 N
GLU 68 21.326 67.300 -2.473 1.00 0.40 1SG 531 ATOM 531 CA GLU 68
21.354 68.137 -1.311 1.00 0.40 1SG 532 ATOM 532 CB GLU 68 22.726
68.230 -0.620 1.00 0.40 1SG 533 ATOM 533 CG GLU 68 23.845 68.792
-1.495 1.00 0.40 1SG 534 ATOM 534 CD GLU 68 25.108 68.817 -0.647
1.00 0.40 1SG 535 ATOM 535 OE1 GLU 68 25.663 67.720 -0.373 1.00
0.40 1SG 536 ATOM 536 OE2 GLU 68 25.528 69.937 -0.250 1.00 0.40 1SG
537 ATOM 537 C GLU 68 20.920 69.512 -1.698 1.00 0.40 1SG 538 ATOM
538 O GLU 68 21.211 69.986 -2.795 1.00 0.40 1SG 539 ATOM 539 N TYR
69 20.167 70.173 -0.796 1.00 0.34 1SG 540 ATOM 540 CA TYR 69 19.709
71.508 -1.056 1.00 0.34 1SG 541 ATOM 541 CB TYR 69 18.186 71.697
-0.940 1.00 0.34 1SG 542 ATOM 542 CG TYR 69 17.520 71.002 -2.077
1.00 0.34 1SG 543 ATOM 543 CD1 TYR 69 17.280 69.648 -2.029 1.00
0.34 1SG 544 ATOM 544 CD2 TYR 69 17.127 71.715 -3.187 1.00 0.34 1SG
545 ATOM 545 CE1 TYR 69 16.661 69.014 -3.080 1.00 0.34 1SG 546 ATOM
546 CE2 TYR 69 16.507 71.087 -4.240 1.00 0.34 1SG 547 ATOM 547 CZ
TYR 69 16.275 69.733 -4.186 1.00 0.34 1SG 548 ATOM 548 OH TYR 69
15.639 69.084 -5.265 1.00 0.34 1SG 549 ATOM 549 C TYR 69 20.315
72.420 -0.037 1.00 0.34 1SG 550 ATOM 550 O TYR 69 20.468 72.053
1.127 1.00 0.34 1SG 551 ATOM 551 N ARG 70 20.700 73.640 -0.468 1.00
0.33 1SG 552 ATOM 552 CA ARG 70 21.233 74.613 0.442 1.00 0.33 1SG
553 ATOM 553 CB ARG 70 22.767 74.627 0.507 1.00 0.33 1SG 554 ATOM
554 CG ARG 70 23.309 73.406 1.253 1.00 0.33 1SG 555 ATOM 555 CD ARG
70 24.830 73.388 1.424 1.00 0.33 1SG 556 ATOM 556 NE ARG 70 25.431
72.997 0.119 1.00 0.33 1SG 557 ATOM 557 CZ ARG 70 26.690 72.472
0.081 1.00 0.33 1SG 558 ATOM 558 NH1 ARG 70 27.408 72.344 1.235
1.00 0.33 1SG 559 ATOM 559 NH2 ARG 70 27.226 72.071 -1.108 1.00
0.33 1SG 560 ATOM 560 C ARG 70 20.752 75.964 0.004 1.00 0.33 1SG
561 ATOM 561 O ARG 70 20.274 76.125 -1.117 1.00 0.33 1SG 562 ATOM
562 N CYS 71 20.825 76.972 0.900 1.00 0.26 1SG 563 ATOM 563 CA CYS
71 20.377 78.289 0.535 1.00 0.26 1SG 564 ATOM 564 CB CYS 71 18.893
78.555 0.864 1.00 0.26 1SG 565 ATOM 565 SG CYS 71 18.496 78.615
2.636 1.00 0.26
1SG 566 ATOM 566 C CYS 71 21.235 79.307 1.221 1.00 0.26 1SG 567
ATOM 567 O CYS 71 21.949 78.991 2.172 1.00 0.26 1SG 568 ATOM 568 N
GLN 72 21.215 80.559 0.711 1.00 0.14 1SG 569 ATOM 569 CA GLN 72
22.005 81.615 1.278 1.00 0.14 1SG 570 ATOM 570 CB GLN 72 23.405
81.712 0.643 1.00 0.14 1SG 571 ATOM 571 CG GLN 72 24.303 82.785
1.260 1.00 0.14 1SG 572 ATOM 572 CD GLN 72 25.638 82.750 0.528 1.00
0.14 1SG 573 ATOM 573 OE1 GLN 72 25.792 82.069 -0.485 1.00 0.14 1SG
574 ATOM 574 NE2 GLN 72 26.634 83.512 1.054 1.00 0.14 1SG 575 ATOM
575 C GLN 72 21.301 82.918 1.026 1.00 0.14 1SG 576 ATOM 576 O GLN
72 20.515 83.054 0.087 1.00 0.14 1SG 577 ATOM 577 N THR 73 21.576
83.916 1.892 1.00 0.16 1SG 578 ATOM 578 CA THR 73 21.012 85.228
1.773 1.00 0.16 1SG 579 ATOM 579 CB THR 73 20.152 85.599 2.951 1.00
0.16 1SG 580 ATOM 580 OG1 THR 73 19.141 84.620 3.135 1.00 0.16 1SG
581 ATOM 581 CG2 THR 73 19.486 86.959 2.679 1.00 0.16 1SG 582 ATOM
582 C THR 73 22.191 86.155 1.737 1.00 0.16 1SG 583 ATOM 583 O THR
73 23.325 85.730 1.942 1.00 0.16 1SG 584 ATOM 584 N ASN 74 21.971
87.447 1.435 1.00 0.21 1SG 585 ATOM 585 CA ASN 74 23.072 88.368
1.377 1.00 0.21 1SG 586 ATOM 586 CB ASN 74 22.697 89.763 0.849 1.00
0.21 1SG 587 ATOM 587 CG ASN 74 22.617 89.670 -0.669 1.00 0.21 1SG
588 ATOM 588 OD1 ASN 74 22.270 90.635 -1.348 1.00 0.21 1SG 589 ATOM
589 ND2 ASN 74 22.961 88.475 -1.220 1.00 0.21 1SG 590 ATOM 590 C
ASN 74 23.669 88.525 2.743 1.00 0.21 1SG 591 ATOM 591 O ASN 74
24.859 88.807 2.867 1.00 0.21 1SG 592 ATOM 592 N LEU 75 22.825
88.433 3.790 1.00 0.22 1SG 593 ATOM 593 CA LEU 75 23.180 88.556
5.181 1.00 0.22 1SG 594 ATOM 594 CB LEU 75 21.987 88.944 6.070 1.00
0.22 1SG 595 ATOM 595 CG LEU 75 21.434 90.348 5.763 1.00 0.22 1SG
596 ATOM 596 CD2 LEU 75 22.562 91.388 5.672 1.00 0.22 1SG 597 ATOM
597 CD1 LEU 75 20.333 90.745 6.759 1.00 0.22 1SG 598 ATOM 598 C LEU
75 23.804 87.324 5.785 1.00 0.22 1SG 599 ATOM 599 O LEU 75 24.481
87.437 6.802 1.00 0.22 1SG 600 ATOM 600 N SER 76 23.574 86.107
5.251 1.00 0.32 1SG 601 ATOM 601 CA SER 76 24.037 84.956 5.989 1.00
0.32 1SG 602 ATOM 602 CB SER 76 22.883 84.027 6.399 1.00 0.32 1SG
603 ATOM 603 OG SER 76 22.213 83.551 5.240 1.00 0.32 1SG 604 ATOM
604 C SER 76 25.017 84.125 5.215 1.00 0.32 1SG 605 ATOM 605 O SER
76 25.282 84.360 4.038 1.00 0.32 1SG 606 ATOM 606 N THR 77 25.634
83.142 5.909 1.00 0.43 1SG 607 ATOM 607 CA THR 77 26.525 82.222
5.261 1.00 0.43 1SG 608 ATOM 608 CB THR 77 27.567 81.655 6.174 1.00
0.43 1SG 609 ATOM 609 OG1 THR 77 26.955 80.928 7.228 1.00 0.43 1SG
610 ATOM 610 CG2 THR 77 28.385 82.825 6.745 1.00 0.43 1SG 611 ATOM
611 C THR 77 25.663 81.111 4.734 1.00 0.43 1SG 612 ATOM 612 O THR
77 24.471 81.058 5.032 1.00 0.43 1SG 613 ATOM 613 N LEU 78 26.241
80.196 3.928 1.00 0.27 1SG 614 ATOM 614 CA LEU 78 25.474 79.156
3.293 1.00 0.27 1SG 615 ATOM 615 CB LEU 78 26.307 78.312 2.309 1.00
0.27 1SG 616 ATOM 616 CG LEU 78 25.499 77.245 1.545 1.00 0.27 1SG
617 ATOM 617 CD2 LEU 78 26.425 76.234 0.850 1.00 0.27 1SG 618 ATOM
618 CD1 LEU 78 24.498 77.891 0.572 1.00 0.27 1SG 619 ATOM 619 C LEU
78 24.920 78.243 4.345 1.00 0.27 1SG 620 ATOM 620 O LEU 78 25.581
77.931 5.333 1.00 0.27 1SG 621 ATOM 621 N SER 79 23.667 77.783
4.149 1.00 0.11 1SG 622 ATOM 622 CA SER 79 23.037 76.937 5.124 1.00
0.11 1SG 623 ATOM 623 CB SER 79 21.513 76.815 4.955 1.00 0.11 1SG
624 ATOM 624 OG SER 79 21.213 76.083 3.776 1.00 0.11 1SG 625 ATOM
625 C SER 79 23.595 75.557 5.010 1.00 0.11 1SG 626 ATOM 626 O SER
79 24.203 75.200 4.001 1.00 0.11 1SG 627 ATOM 627 N ASP 80 23.417
74.752 6.079 1.00 0.14 1SG 628 ATOM 628 CA ASP 80 23.841 73.383
6.047 1.00 0.14 1SG 629 ATOM 629 CB ASP 80 23.747 72.664 7.406 1.00
0.14 1SG 630 ATOM 630 CG ASP 80 24.820 73.215 8.338 1.00 0.14 1SG
631 ATOM 631 OD1 ASP 80 25.741 73.920 7.845 1.00 0.14 1SG 632 ATOM
632 OD2 ASP 80 24.733 72.931 9.562 1.00 0.14 1SG 633 ATOM 633 C ASP
80 22.908 72.703 5.097 1.00 0.14 1SG 634 ATOM 634 O ASP 80 21.786
73.158 4.880 1.00 0.14 1SG 635 ATOM 635 N PRO 81 23.361 71.635
4.504 1.00 0.17 1SG 636 ATOM 636 CA PRO 81 22.566 70.959 3.515 1.00
0.17 1SG 637 ATOM 637 CD PRO 81 24.783 71.457 4.267 1.00 0.17 1SG
638 ATOM 638 CB PRO 81 23.545 70.174 2.637 1.00 0.17 1SG 639 ATOM
639 CG PRO 81 24.867 70.176 3.423 1.00 0.17 1SG 640 ATOM 640 C PRO
81 21.445 70.127 4.045 1.00 0.17 1SG 641 ATOM 641 O PRO 81 21.508
69.669 5.185 1.00 0.17 1SG 642 ATOM 642 N VAL 82 20.396 69.960
3.216 1.00 0.16 1SG 643 ATOM 643 CA VAL 82 19.285 69.101 3.498 1.00
0.16 1SG 644 ATOM 644 CB VAL 82 17.966 69.817 3.475 1.00 0.16 1SG
645 ATOM 645 CG1 VAL 82 16.840 68.794 3.699 1.00 0.16 1SG 646 ATOM
646 CG2 VAL 82 18.008 70.940 4.524 1.00 0.16 1SG 647 ATOM 647 C VAL
82 19.286 68.130 2.359 1.00 0.16 1SG 648 ATOM 648 O VAL 82 19.289
68.539 1.198 1.00 0.16 1SG 649 ATOM 649 N GLN 83 19.288 66.815
2.656 1.00 0.14 1SG 650 ATOM 650 CA GLN 83 19.369 65.853 1.595 1.00
0.14 1SG 651 ATOM 651 CB GLN 83 20.289 64.661 1.909 1.00 0.14 1SG
652 ATOM 652 CG GLN 83 20.361 63.653 0.761 1.00 0.14 1SG 653 ATOM
653 CD GLN 83 21.289 62.516 1.166 1.00 0.14 1SG 654 ATOM 654 OE1
GLN 83 21.088 61.372 0.761 1.00 0.14 1SG 655 ATOM 655 NE2 GLN 83
22.329 62.832 1.983 1.00 0.14 1SG 656 ATOM 656 C GLN 83 18.000
65.310 1.325 1.00 0.14 1SG 657 ATOM 657 O GLN 83 17.266 64.946
2.241 1.00 0.14 1SG 658 ATOM 658 N LEU 84 17.623 65.249 0.031 1.00
0.13 1SG 659 ATOM 659 CA LEU 84 16.313 64.773 -0.309 1.00 0.13 1SG
660 ATOM 660 CB LEU 84 15.463 65.842 -1.024 1.00 0.13 1SG 661 ATOM
661 CG LEU 84 14.045 65.379 -1.404 1.00 0.13 1SG 662 ATOM 662 CD2
LEU 84 13.376 66.379 -2.362 1.00 0.13 1SG 663 ATOM 663 CD1 LEU 84
13.193 65.093 -0.157 1.00 0.13 1SG 664 ATOM 664 C LEU 84 16.463
63.601 -1.234 1.00 0.13 1SG 665 ATOM 665 O LEU 84 17.358 63.578
-2.077 1.00 0.13 1SG 666 ATOM 666 N GLU 85 15.609 62.565 -1.067
1.00 0.13 1SG 667 ATOM 667 CA GLU 85 15.659 61.442 -1.962 1.00 0.13
1SG 668 ATOM 668 CB GLU 85 16.128 60.122 -1.323 1.00 0.13 1SG 669
ATOM 669 CG GLU 85 17.623 60.111 -0.993 1.00 0.13 1SG 670 ATOM 670
CD GLU 85 18.029 58.680 -0.673 1.00 0.13 1SG 671 ATOM 671 OE1 GLU
85 17.391 58.068 0.224 1.00 0.13 1SG 672 ATOM 672 OE2 GLU 85 18.980
58.178 -1.330 1.00 0.13 1SG 673 ATOM 673 C GLU 85 14.284 61.216
-2.512 1.00 0.13 1SG 674 ATOM 674 O GLU 85 13.323 61.034 -1.765
1.00 0.13 1SG 675 ATOM 675 N VAL 86 14.161 61.211 -3.855 1.00 0.18
1SG 676 ATOM 676 CA VAL 86 12.880 61.025 -4.470 1.00 0.18 1SG 677
ATOM 677 CB VAL 86 12.628 61.986 -5.593 1.00 0.18 1SG 678 ATOM 678
CG1 VAL 86 11.244 61.699 -6.195 1.00 0.18 1SG 679 ATOM 679 CG2 VAL
86 12.774 63.413 -5.038 1.00 0.18 1SG 680 ATOM 680 C VAL 86 12.831
59.631 -5.014 1.00 0.18 1SG 681 ATOM 681 O VAL 86 13.746 59.188
-5.708 1.00 0.18 1SG 682 ATOM 682 N HIS 87 11.743 58.893 -4.710
1.00 0.34 1SG 683 ATOM 683 CA HIS 87 11.681 57.522 -5.133 1.00 0.34
1SG 684 ATOM 684 ND1 HIS 87 13.107 57.437 -2.117 1.00 0.34 1SG 685
ATOM 685 CG HIS 87 12.856 56.525 -3.119 1.00 0.34 1SG 686 ATOM 686
CB HIS 87 11.614 56.524 -3.963 1.00 0.34 1SG 687 ATOM 687 NE2 HIS
87 14.860 56.069 -2.186 1.00 0.34 1SG 688 ATOM 688 CD2 HIS 87
13.936 55.697 -3.147 1.00 0.34 1SG 689 ATOM 689 CE1 HIS 87 14.318
57.118 -1.593 1.00 0.34 1SG 690 ATOM 690 C HIS 87 10.467 57.302
-5.978 1.00 0.34 1SG 691 ATOM 691 O HIS 87 9.539 58.109 -5.995 1.00
0.34 1SG 692 ATOM 692 N ILE 88 10.485 56.205 -6.762 1.00 0.38 1SG
693 ATOM 693 CA ILE 88 9.339 55.850 -7.542 1.00 0.38 1SG 694 ATOM
694 CB ILE 88 9.605 55.807 -9.024 1.00 0.38 1SG 695 ATOM 695 CG2
ILE 88 10.824 54.912 -9.310 1.00 0.38 1SG 696 ATOM 696 CG1 ILE 88
8.323 55.418 -9.776 1.00 0.38 1SG 697 ATOM 697 CD1 ILE 88 8.409
55.623 -11.288 1.00 0.38 1SG 698 ATOM 698 C ILE 88 8.899 54.495
-7.072 1.00 0.38 1SG 699 ATOM 699 O ILE 88 9.501 53.472 -7.396 1.00
0.38 1SG 700 ATOM 700 N GLY 89 7.809 54.464 -6.281 1.00 0.20 1SG
701 ATOM 701 CA GLY 89 7.304 53.227 -5.757 1.00 0.20 1SG 702 ATOM
702 C GLY 89 5.901 53.499 -5.315 1.00 0.20 1SG 703 ATOM 703 O GLY
89 5.512 54.651 -5.141 1.00 0.20 1SG 704 ATOM 704 N TRP 90 5.094
52.434 -5.147 1.00 0.12 1SG 705 ATOM 705 CA TRP 90 3.723 52.586
-4.750 1.00 0.12 1SG 706 ATOM 706 CB TRP 90 2.880 51.313 -4.922
1.00 0.12 1SG 707 ATOM 707 CG TRP 90 2.518 51.031 -6.358 1.00 0.12
1SG 708 ATOM 708 CD2 TRP 90 1.448 51.700 -7.042 1.00 0.12 1SG 709
ATOM 709 CD1 TRP 90 3.076 50.170 -7.258 1.00 0.12 1SG 710 ATOM 710
NE1 TRP 90 2.414 50.255 -8.460 1.00 0.12 1SG 711 ATOM 711 CE2 TRP
90 1.410 51.195 -8.341 1.00 0.12 1SG 712 ATOM 712 CE3 TRP 90 0.569
52.657 -6.619 1.00 0.12 1SG 713 ATOM 713 CZ2 TRP 90 0.486 51.642
-9.241 1.00 0.12 1SG 714 ATOM 714 CZ3 TRP 90 -0.361 53.107 -7.529
1.00 0.12 1SG 715 ATOM 715 CH2 TRP 90 -0.400 52.608 -8.815 1.00
0.12 1SG 716 ATOM 716 C TRP 90 3.580 53.037 -3.324 1.00 0.12 1SG
717 ATOM 717 O TRP 90 2.663 53.800 -3.022 1.00 0.12 1SG 718 ATOM
718 N LEU 91 4.446 52.560 -2.403 1.00 0.26 1SG 719 ATOM 719 CA LEU
91 4.266 52.905 -1.015 1.00 0.26 1SG 720 ATOM 720 CB LEU 91 3.562
51.776 -0.239 1.00 0.26 1SG 721 ATOM 721 CG LEU 91 3.157 52.126
1.203 1.00 0.26 1SG 722 ATOM 722 CD2 LEU 91 2.734 50.869 1.981 1.00
0.26 1SG 723 ATOM 723 CD1 LEU 91 2.079 53.222 1.222 1.00 0.26 1SG
724 ATOM 724 C LEU 91 5.614 53.138 -0.385 1.00 0.26 1SG 725 ATOM
725 O LEU 91 6.577 52.431 -0.677 1.00 0.26 1SG 726 ATOM 726 N LEU
92 5.719 54.138 0.522 1.00 0.38 1SG 727 ATOM 727 CA LEU 92 6.998
54.439 1.103 1.00 0.38 1SG 728 ATOM 728 CB LEU 92 7.560 55.735
0.473 1.00 0.38 1SG 729 ATOM 729 CG LEU 92 9.071 56.015 0.609 1.00
0.38 1SG 730 ATOM 730 CD2 LEU 92 9.558 55.970 2.057 1.00 0.38 1SG
731 ATOM 731 CD1 LEU 92 9.434 57.344 -0.076 1.00 0.38 1SG 732 ATOM
732 C LEU 92 6.810 54.634 2.588 1.00 0.38 1SG 733 ATOM 733 O LEU 92
5.768 55.108 3.043 1.00 0.38 1SG 734 ATOM 734 N LEU 93 7.804 54.221
3.402 1.00 0.28 1SG 735 ATOM 735 CA LEU 93 7.741 54.488 4.812 1.00
0.28 1SG 736 ATOM 736 CB LEU 93 8.385 53.414 5.695 1.00 0.28 1SG
737 ATOM 737 CG LEU 93 8.272 53.774 7.184 1.00 0.28 1SG 738 ATOM
738 CD2 LEU 93 9.357 53.085 8.018 1.00 0.28 1SG 739 ATOM 739 CD1
LEU 93 6.842 53.566 7.705 1.00 0.28 1SG 740 ATOM 740 C LEU 93 8.566
55.725 5.002 1.00 0.28 1SG 741 ATOM 741 O LEU 93 9.775 55.710 4.770
1.00 0.28 1SG 742 ATOM 742 N GLN 94 7.949 56.830 5.464 1.00 0.17
1SG 743 ATOM 743 CA GLN 94 8.665 58.079 5.487 1.00 0.17 1SG 744
ATOM 744 CB GLN 94 7.823 59.244 4.936 1.00 0.17 1SG 745 ATOM 745 CG
GLN 94 7.457 59.079 3.456 1.00 0.17 1SG 746 ATOM 746 CD GLN 94
6.482 60.183 3.068 1.00 0.17 1SG 747 ATOM 747 OE1 GLN 94 5.403
60.300 3.646 1.00 0.17 1SG 748 ATOM 748 NE2 GLN 94 6.867 61.016
2.063 1.00 0.17 1SG 749 ATOM 749 C GLN 94 9.119 58.445 6.869 1.00
0.17 1SG 750 ATOM 750 O GLN 94 8.489 58.092 7.864 1.00 0.17 1SG 751
ATOM 751 N ALA 95 10.270 59.157 6.949 1.00 0.22 1SG 752 ATOM 752 CA
ALA 95 10.807 59.602 8.209 1.00 0.22 1SG 753 ATOM 753 CB ALA 95
11.868 58.652 8.789 1.00 0.22 1SG 754 ATOM 754 C ALA 95 11.466
60.944 8.020 1.00 0.22 1SG 755 ATOM 755 O ALA 95 11.923 61.281
6.929 1.00 0.22 1SG 756 ATOM 756 N PRO 96 11.450 61.752 9.055 1.00
0.32 1SG 757 ATOM 757 CA PRO 96 12.110 63.037 9.060 1.00 0.32 1SG
758 ATOM 758 CD PRO 96 10.425 61.656 10.079 1.00 0.32 1SG 759 ATOM
759 CB PRO 96 11.422 63.855 10.153 1.00 0.32 1SG 760 ATOM 760 CG
PRO 96 10.741 62.805 11.048 1.00 0.32 1SG 761 ATOM 761 C PRO 96
13.591 62.923 9.280 1.00 0.32 1SG 762 ATOM 762 O PRO 96 14.314
63.852 8.921 1.00 0.32 1SG 763 ATOM 763 N ARG 97 14.065 61.820
9.898 1.00 0.53 1SG 764 ATOM 764 CA ARG 97 15.473 61.698 10.174
1.00 0.53 1SG 765 ATOM 765 CB ARG 97 15.898 62.263 11.541 1.00 0.53
1SG 766 ATOM 766 CG ARG 97 15.826 63.783 11.675 1.00 0.53 1SG 767
ATOM 767 CD ARG 97 16.303 64.269 13.047 1.00 0.53 1SG 768 ATOM 768
NE ARG 97 16.192 65.754 13.073 1.00 0.53 1SG 769 ATOM 769 CZ ARG 97
16.441 66.436 14.229 1.00 0.53 1SG 770 ATOM 770 NH1 ARG 97 16.772
65.759 15.367 1.00 0.53 1SG 771 ATOM 771 NH2 ARG 97 16.358 67.798
14.244 1.00 0.53 1SG 772 ATOM 772 C ARG 97 15.838 60.245 10.235
1.00 0.53 1SG 773 ATOM 773 O ARG 97 14.998 59.389 10.508 1.00 0.53
1SG 774 ATOM 774 N TRP 98 17.112 59.947 9.899 1.00 0.63 1SG 775
ATOM 775 CA TRP 98 17.708 58.639 9.981 1.00 0.63 1SG 776 ATOM 776
CB TRP 98 19.044 58.563 9.225 1.00 0.63 1SG 777 ATOM 777 CG TRP 98
18.963 58.722 7.727 1.00 0.63 1SG 778 ATOM 778 CD2 TRP 98 19.073
57.635 6.796 1.00 0.63 1SG 779 ATOM 779 CD1 TRP 98 18.829 59.858
6.982 1.00 0.63 1SG 780 ATOM 780 NE1 TRP 98 18.849 59.546 5.644
1.00 0.63 1SG 781 ATOM 781 CE2 TRP 98 19.000 58.181 5.515 1.00 0.63
1SG 782 ATOM 782 CE3 TRP 98 19.231 56.293 6.993 1.00 0.63 1SG 783
ATOM 783 CZ2 TRP 98 19.083 57.388 4.406 1.00 0.63 1SG 784 ATOM 784
CZ3 TRP 98 19.308 55.495 5.873 1.00 0.63 1SG 785 ATOM 785 CH2 TRP
98 19.235 56.033 4.604 1.00 0.63 1SG 786 ATOM 786 C TRP 98 18.054
58.309 11.401 1.00 0.63 1SG 787 ATOM 787 O TRP 98 17.880 57.176
11.851 1.00 0.63 1SG 788 ATOM 788 N VAL 99 18.595 59.298 12.142
1.00 0.34 1SG 789 ATOM 789 CA VAL 99 19.048 59.025 13.477 1.00 0.34
1SG 790 ATOM 790 CB VAL 99 20.524 59.219 13.662 1.00 0.34 1SG 791
ATOM 791 CG1 VAL 99 20.863 58.957 15.139 1.00 0.34 1SG 792 ATOM 792
CG2 VAL 99 21.271 58.304 12.676 1.00 0.34 1SG 793 ATOM 793 C VAL 99
18.367 59.959 14.419 1.00 0.34 1SG 794 ATOM 794 O VAL 99 18.049
61.095 14.072 1.00 0.34 1SG 795 ATOM 795 N PHE 100 18.120 59.475
15.651 1.00 0.22 1SG 796 ATOM 796 CA PHE 100 17.482 60.261 16.666
1.00 0.22 1SG 797 ATOM 797 CB PHE 100 16.050 59.805 17.011 1.00
0.22 1SG 798 ATOM 798 CG PHE 100 15.147 60.050 15.850 1.00 0.22 1SG
799 ATOM 799 CD1 PHE 100 15.045 59.126 14.835 1.00 0.22 1SG 800
ATOM 800 CD2 PHE 100 14.393 61.200 15.781 1.00 0.22 1SG 801 ATOM
801 CE1 PHE 100 14.210 59.348 13.765 1.00 0.22 1SG 802 ATOM 802 CE2
PHE 100 13.557 61.428 14.714 1.00 0.22 1SG 803 ATOM 803 CZ PHE 100
13.464 60.501 13.704 1.00 0.22 1SG 804 ATOM 804 C PHE 100 18.269
60.096 17.929 1.00 0.22 1SG 805 ATOM 805 O PHE 100 19.106 59.202
18.044 1.00 0.22 1SG 806 ATOM 806 N LYS 101 18.022 60.982 18.914
1.00 0.37 1SG 807 ATOM 807 CA LYS 101 18.685 60.871 20.179 1.00
0.37 1SG 808 ATOM 808 CB LYS 101 19.121 62.219 20.781 1.00 0.37 1SG
809 ATOM 809 CG LYS 101 20.001 62.084 22.025 1.00 0.37 1SG 810 ATOM
810 CD LYS 101 20.705 63.381 22.431 1.00 0.37 1SG 811 ATOM 811 CE
LYS 101 21.583 63.228 23.674 1.00 0.37 1SG 812 ATOM 812 NZ LYS 101
20.740 62.951 24.858 1.00 0.37 1SG 813 ATOM 813 C LYS 101 17.693
60.252 21.105 1.00 0.37 1SG 814 ATOM 814 O LYS 101 16.495 60.245
20.827 1.00 0.37 1SG 815 ATOM 815 N GLU 102 18.163 59.687 22.231
1.00 0.39 1SG 816 ATOM 816 CA GLU 102 17.220 59.044 23.095 1.00
0.39 1SG 817 ATOM 817 CB GLU 102 17.844 58.321 24.301 1.00 0.39 1SG
818 ATOM 818 CG GLU 102 16.843 57.503 25.120 1.00 0.39 1SG 819 ATOM
819 CD GLU 102 17.615 56.757 26.198 1.00 0.39 1SG 820 ATOM 820 OE1
GLU 102 18.311 57.431 27.003 1.00 0.39 1SG 821 ATOM 821 OE2 GLU 102
17.521 55.500 26.228 1.00 0.39 1SG 822 ATOM 822 C GLU 102 16.283
60.078 23.620 1.00 0.39 1SG 823 ATOM 823 O GLU 102 16.670 61.220
23.867 1.00 0.39 1SG 824 ATOM 824 N GLU 103 15.011 59.670 23.799
1.00 0.36 1SG 825 ATOM 825 CA GLU 103 13.964 60.488 24.342 1.00
0.36 1SG 826 ATOM 826 CB GLU 103 14.455 61.396 25.484 1.00 0.36 1SG
827 ATOM 827 CG GLU 103 13.329 62.144 26.202 1.00 0.36 1SG 828 ATOM
828 CD GLU 103 13.884 62.673 27.516 1.00 0.36 1SG 829 ATOM 829 OE1
GLU 103 14.575 63.727 27.492 1.00 0.36 1SG 830 ATOM 830 OE2 GLU 103
13.629 62.021 28.564 1.00 0.36 1SG 831 ATOM 831 C GLU 103 13.304
61.337 23.292 1.00 0.36 1SG 832 ATOM 832 O GLU 103 12.292 61.973
23.577 1.00 0.36 1SG 833 ATOM 833 N ASP 104 13.805 61.348 22.040
1.00 0.43 1SG 834 ATOM 834 CA ASP 104 13.164 62.158 21.035 1.00
0.43 1SG 835 ATOM 835 CB ASP 104 14.062 62.472 19.824 1.00 0.43 1SG
836 ATOM 836 CG ASP 104 15.128 63.467 20.261 1.00 0.43 1SG 837 ATOM
837 OD1 ASP 104 14.791 64.371 21.072 1.00 0.43 1SG 838 ATOM 838 OD2
ASP 104 16.289 63.343 19.786 1.00 0.43 1SG 839 ATOM 839 C ASP 104
11.960 61.429 20.519 1.00 0.43 1SG 840 ATOM 840 O ASP 104 11.861
60.207 20.619 1.00 0.43 1SG 841 ATOM 841 N PRO 105 11.000 62.175
20.031 1.00 0.49 1SG 842 ATOM 842 CA PRO 105 9.848 61.540 19.444
1.00 0.49 1SG 843 ATOM 843 CD PRO 105 10.635 63.393 20.738 1.00
0.49 1SG 844 ATOM 844 CB PRO 105 8.700 62.541 19.551 1.00 0.49 1SG
845 ATOM 845 CG PRO 105 9.098 63.424 20.745 1.00 0.49 1SG 846 ATOM
846 C PRO 105 10.124 61.111 18.035 1.00 0.49 1SG 847 ATOM 847 O PRO
105 10.660 61.908 17.264 1.00
0.49 1SG 848 ATOM 848 N ILE 106 9.727 59.883 17.652 1.00 0.36 1SG
849 ATOM 849 CA ILE 106 9.943 59.473 16.295 1.00 0.36 1SG 850 ATOM
850 CB ILE 106 10.523 58.093 16.165 1.00 0.36 1SG 851 ATOM 851 CG2
ILE 106 10.559 57.725 14.672 1.00 0.36 1SG 852 ATOM 852 CG1 ILE 106
11.905 58.028 16.839 1.00 0.36 1SG 853 ATOM 853 CD1 ILE 106 12.457
56.609 16.964 1.00 0.36 1SG 854 ATOM 854 C ILE 106 8.601 59.479
15.637 1.00 0.36 1SG 855 ATOM 855 O ILE 106 7.648 58.886 16.143
1.00 0.36 1SG 856 ATOM 856 N HIS 107 8.487 60.185 14.495 1.00 0.24
1SG 857 ATOM 857 CA HIS 107 7.250 60.266 13.772 1.00 0.24 1SG 858
ATOM 858 ND1 HIS 107 5.419 61.664 11.375 1.00 0.24 1SG 859 ATOM 859
CG HIS 107 5.521 61.800 12.741 1.00 0.24 1SG 860 ATOM 860 CB HIS
107 6.811 61.712 13.496 1.00 0.24 1SG 861 ATOM 861 NE2 HIS 107
3.359 62.008 12.134 1.00 0.24 1SG 862 ATOM 862 CD2 HIS 107 4.254
62.011 13.189 1.00 0.24 1SG 863 ATOM 863 CE1 HIS 107 4.105 61.797
11.065 1.00 0.24 1SG 864 ATOM 864 C HIS 107 7.455 59.623 12.437
1.00 0.24 1SG 865 ATOM 865 O HIS 107 8.426. 59.919 11.743 1.00 0.24
1SG 866 ATOM 866 N LEU 108 6.532 58.728 12.034 1.00 0.32 1SG 867
ATOM 867 CA LEU 108 6.678 58.051 10.776 1.00 0.32 1SG 868 ATOM 868
CB LEU 108 7.053 56.568 10.922 1.00 0.32 1SG 869 ATOM 869 CG LEU
108 8.401 56.337 11.629 1.00 0.32 1SG 870 ATOM 870 CD2 LEU 108
9.528 57.138 10.963 1.00 0.32 1SG 871 ATOM 871 CD1 LEU 108 8.722
54.838 11.741 1.00 0.32 1SG 872 ATOM 872 C LEU 108 5.365 58.089
10.057 1.00 0.32 1SG 873 ATOM 873 O LEU 108 4.317 58.287 10.669
1.00 0.32 1SG 874 ATOM 874 N ARG 109 5.391 57.926 8.715 1.00 0.56
1SG 875 ATOM 875 CA ARG 109 4.152 57.926 7.992 1.00 0.56 1SG 876
ATOM 876 CB ARG 109 3.759 59.308 7.445 1.00 0.56 1SG 877 ATOM 877
CG ARG 109 2.437 59.292 6.678 1.00 0.56 1SG 878 ATOM 878 CD ARG 109
1.919 60.679 6.297 1.00 0.56 1SG 879 ATOM 879 NE ARG 109 2.988
61.367 5.522 1.00 0.56 1SG 880 ATOM 880 CZ ARG 109 2.734 61.825
4.262 1.00 0.56 1SG 881 ATOM 881 NH1 ARG 109 1.540 61.554 3.664
1.00 0.56 1SG 882 ATOM 882 NH2 ARG 109 3.674 62.558 3.597 1.00 0.56
1SG 883 ATOM 883 C ARG 109 4.246 56.981 6.835 1.00 0.56 1SG 884
ATOM 884 O ARG 109 5.286 56.856 6.190 1.00 0.56 1SG 885 ATOM 885 N
CYS 110 3.129 56.286 6.547 1.00 0.57 1SG 886 ATOM 886 CA CYS 110
3.049 55.357 5.458 1.00 0.57 1SG 887 ATOM 887 CB CYS 110 2.169
54.160 5.827 1.00 0.57 1SG 888 ATOM 888 SG CYS 110 2.263 52.785
4.659 1.00 0.57 1SG 889 ATOM 889 C CYS 110 2.373 56.124 4.366 1.00
0.57 1SG 890 ATOM 890 O CYS 110 1.224 56.532 4.524 1.00 0.57 1SG
891 ATOM 891 N HIS 111 3.069 56.339 3.228 1.00 0.38 1SG 892 ATOM
892 CA HIS 111 2.538 57.210 2.212 1.00 0.38 1SG 893 ATOM 893 ND1
HIS 111 3.845 59.725 -0.098 1.00 0.38 1SG 894 ATOM 894 CG HIS 111
3.026 59.397 0.958 1.00 0.38 1SG 895 ATOM 895 CB HIS 111 3.431
58.454 2.048 1.00 0.38 1SG 896 ATOM 896 NE2 HIS 111 1.950 60.848
-0.391 1.00 0.38 1SG 897 ATOM 897 CD2 HIS 111 1.872 60.091 0.765
1.00 0.38 1SG 898 ATOM 898 CE1 HIS 111 3.153 60.597 -0.874 1.00
0.38 1SG 899 ATOM 899 C HIS 111 2.419 56.523 0.884 1.00 0.38 1SG
900 ATOM 900 O HIS 111 3.335 55.837 0.435 1.00 0.38 1SG 901 ATOM
901 N SER 112 1.273 56.736 0.198 1.00 0.32 1SG 902 ATOM 902 CA SER
112 1.044 56.101 -1.070 1.00 0.32 1SG 903 ATOM 903 CB SER 112
-0.389 55.569 -1.218 1.00 0.32 1SG 904 ATOM 904 OG SER 112 -0.492
54.787 -2.396 1.00 0.32 1SG 905 ATOM 905 C SER 112 1.307 57.088
-2.172 1.00 0.32 1SG 906 ATOM 906 O SER 112 1.242 58.302 -1.980
1.00 0.32 1SG 907 ATOM 907 N TRP 113 1.638 56.569 -3.372 1.00 0.30
1SG 908 ATOM 908 CA TRP 113 1.963 57.399 -4.497 1.00 0.30 1SG 909
ATOM 909 CB TRP 113 2.495 56.585 -5.697 1.00 0.30 1SG 910 ATOM 910
CG TRP 113 2.901 57.379 -6.919 1.00 0.30 1SG 911 ATOM 911 CD2 TRP
113 2.390 57.139 -8.240 1.00 0.30 1SG 912 ATOM 912 CD1 TRP 113
3.833 58.368 -7.040 1.00 0.30 1SG 913 ATOM 913 NE1 TRP 113 3.923
58.771 -8.351 1.00 0.30 1SG 914 ATOM 914 CE2 TRP 113 3.046 58.019
-9.102 1.00 0.30 1SG 915 ATOM 915 CE3 TRP 113 1.459 56.252 -8.700
1.00 0.30 1SG 916 ATOM 916 CZ2 TRP 113 2.778 58.026 -10.441 1.00
0.30 1SG 917 ATOM 917 CZ3 TRP 113 1.187 56.267 -10.050 1.00 0.30
1SG 918 ATOM 918 CH2 TRP 113 1.834 57.138 -10.903 1.00 0.30 1SG 919
ATOM 919 C TRP 113 0.745 58.163 -4.905 1.00 0.30 1SG 920 ATOM 920 O
TRP 113 -0.351 57.617 -5.020 1.00 0.30 1SG 921 ATOM 921 N LYS 114
0.922 59.482 -5.109 1.00 0.27 1SG 922 ATOM 922 CA LYS 114 -0.135
60.350 -5.539 1.00 0.27 1SG 923 ATOM 923 CB LYS 114 -0.677 59.986
-6.931 1.00 0.27 1SG 924 ATOM 924 CG LYS 114 0.364 60.164 -8.037
1.00 0.27 1SG 925 ATOM 925 CD LYS 114 -0.039 59.543 -9.375 1.00
0.27 1SG 926 ATOM 926 CE LYS 114 -0.974 60.429 -10.198 1.00 0.27
1SG 927 ATOM 927 NZ LYS 114 -1.297 59.768 -11.480 1.00 0.27 1SG 928
ATOM 928 C LYS 114 -1.266 60.310 -4.557 1.00 0.27 1SG 929 ATOM 929
O LYS 114 -2.398 60.652 -4.895 1.00 0.27 1SG 930 ATOM 930 N ASN 115
-0.981 59.925 -3.300 1.00 0.32 1SG 931 ATOM 931 CA ASN 115 -1.970
59.921 -2.258 1.00 0.32 1SG 932 ATOM 932 CB ASN 115 -2.435 61.333
-1.858 1.00 0.32 1SG 933 ATOM 933 CG ASN 115 -1.305 61.990 -1.078
1.00 0.32 1SG 934 ATOM 934 OD1 ASN 115 -0.700 61.364 -0.209 1.00
0.32 1SG 935 ATOM 935 ND2 ASN 115 -1.011 63.280 -1.391 1.00 0.32
1SG 936 ATOM 936 C ASN 115 -3.177 59.118 -2.626 1.00 0.32 1SG 937
ATOM 937 O ASN 115 -4.302 59.534 -2.353 1.00 0.32 1SG 938 ATOM 938
N THR 116 -2.997 57.932 -3.236 1.00 0.37 1SG 939 ATOM 939 CA THR
116 -4.165 57.141 -3.495 1.00 0.37 1SG 940 ATOM 940 CB THR 116
-3.909 55.918 -4.321 1.00 0.37 1SG 941 ATOM 941 OG1 THR 116 -5.135
55.293 -4.672 1.00 0.37 1SG 942 ATOM 942 CG2 THR 116 -3.039 54.961
-3.497 1.00 0.37 1SG 943 ATOM 943 C THR 116 -4.668 56.703 -2.156
1.00 0.37 1SG 944 ATOM 944 O THR 116 -3.888 56.517 -1.222 1.00 0.37
1SG 945 ATOM 945 N ALA 117 -5.996 56.517 -2.030 1.00 0.24 1SG 946
ATOM 946 CA ALA 117 -6.570 56.202 -0.752 1.00 0.24 1SG 947 ATOM 947
CB ALA 117 -8.090 55.960 -0.804 1.00 0.24 1SG 948 ATOM 948 C ALA
117 -5.923 54.971 -0.212 1.00 0.24 1SG 949 ATOM 949 O ALA 117
-5.750 53.980 -0.917 1.00 0.24 1SG 950 ATOM 950 N LEU 118 -5.541
55.021 1.081 1.00 0.13 1SG 951 ATOM 951 CA LEU 118 -4.872 53.905
1.683 1.00 0.13 1SG 952 ATOM 952 CB LEU 118 -3.382 54.199 1.945
1.00 0.13 1SG 953 ATOM 953 CG LEU 118 -2.589 53.047 2.592 1.00 0.13
1SG 954 ATOM 954 CD2 LEU 118 -1.222 53.539 3.100 1.00 0.13 1SG 955
ATOM 955 CD1 LEU 118 -2.468 51.846 1.644 1.00 0.13 1SG 956 ATOM 956
C LEU 118 -5.514 53.602 3.006 1.00 0.13 1SG 957 ATOM 957 O LEU 118
-5.848 54.502 3.774 1.00 0.13 1SG 958 ATOM 958 N HIS 119 -5.714
52.300 3.301 1.00 0.15 1SG 959 ATOM 959 CA HIS 119 -6.265 51.906
4.567 1.00 0.15 1SG 960 ATOM 960 ND1 HIS 119 -8.820 53.706 5.627
1.00 0.15 1SG 961 ATOM 961 CG HIS 119 -8.548 52.949 4.510 1.00 0.15
1SG 962 ATOM 962 CB HIS 119 -7.782 51.660 4.549 1.00 0.15 1SG 963
ATOM 963 NE2 HIS 119 -9.697 54.792 3.897 1.00 0.15 1SG 964 ATOM 964
CD2 HIS 119 -9.091 53.626 3.461 1.00 0.15 1SG 965 ATOM 965 CE1 HIS
119 -9.508 54.796 5.205 1.00 0.15 1SG 966 ATOM 966 C HIS 119 -5.579
50.648 5.009 1.00 0.15 1SG 967 ATOM 967 O HIS 119 -4.757 50.091
4.284 1.00 0.15 1SG 968 ATOM 968 N LYS 120 -5.895 50.183 6.236 1.00
0.15 1SG 969 ATOM 969 CA LYS 120 -5.323 48.981 6.778 1.00 0.15 1SG
970 ATOM 970 CB LYS 120 -5.711 47.726 5.981 1.00 0.15 1SG 971 ATOM
971 CG LYS 120 -7.211 47.438 6.003 1.00 0.15 1SG 972 ATOM 972 CD
LYS 120 -7.654 46.446 4.927 1.00 0.15 1SG 973 ATOM 973 CE LYS 120
-9.159 46.178 4.933 1.00 0.15 1SG 974 ATOM 974 NZ LYS 120 -9.537
45.384 3.742 1.00 0.15 1SG 975 ATOM 975 C LYS 120 -3.828 49.079
6.773 1.00 0.15 1SG 976 ATOM 976 O LYS 120 -3.147 48.236 6.191 1.00
0.15 1SG 977 ATOM 977 N VAL 121 -3.270 50.096 7.459 1.00 0.12 1SG
978 ATOM 978 CA VAL 121 -1.847 50.293 7.458 1.00 0.12 1SG 979 ATOM
979 CB VAL 121 -1.443 51.742 7.478 1.00 0.12 1SG 980 ATOM 980 CG1
VAL 121 0.090 51.832 7.576 1.00 0.12 1SG 981 ATOM 981 CG2 VAL 121
-2.025 52.431 6.232 1.00 0.12 1SG 982 ATOM 982 C VAL 121 -1.240
49.648 8.662 1.00 0.12 1SG 983 ATOM 983 O VAL 121 -1.756 49.748
9.775 1.00 0.12 1SG 984 ATOM 984 N THR 122 -0.115 48.932 8.447 1.00
0.20 1SG 985 ATOM 985 CA THR 122 0.569 48.321 9.545 1.00 0.20 1SG
986 ATOM 986 CB THR 122 0.565 46.820 9.506 1.00 0.20 1SG 987 ATOM
987 OG1 THR 122 -0.770 46.335 9.535 1.00 0.20 1SG 988 ATOM 988 CG2
THR 122 1.344 46.294 10.725 1.00 0.20 1SG 989 ATOM 989 C THR 122
1.993 48.778 9.503 1.00 0.20 1SG 990 ATOM 990 O THR 122 2.590
48.895 8.433 1.00 0.20 1SG 991 ATOM 991 N TYR 123 2.562 49.073
10.688 1.00 0.31 1SG 992 ATOM 992 CA TYR 123 3.935 49.480 10.795
1.00 0.31 1SG 993 ATOM 993 CB TYR 123 4.175 50.652 11.755 1.00 0.31
1SG 994 ATOM 994 CG TYR 123 3.858 51.920 11.056 1.00 0.31 1SG 995
ATOM 995 CD1 TYR 123 2.569 52.379 10.913 1.00 0.31 1SG 996 ATOM 996
CD2 TYR 123 4.901 52.652 10.544 1.00 0.31 1SG 997 ATOM 997 CE1 TYR
123 2.334 53.568 10.261 1.00 0.31 1SG 998 ATOM 998 CE2 TYR 123
4.673 53.835 9.896 1.00 0.31 1SG 999 ATOM 999 CZ TYR 123 3.391
54.291 9.756 1.00 0.31 1SG 1000 ATOM 1000 OH TYR 123 3.181 55.511
9.089 1.00 0.31 1SG 1001 ATOM 1001 C TYR 123 4.690 48.339 11.381
1.00 0.31 1SG 1002 ATOM 1002 O TYR 123 4.273 47.764 12.386 1.00
0.31 1SG 1003 ATOM 1003 N LEU 124 5.843 47.994 10.770 1.00 0.32 1SG
1004 ATOM 1004 CA LEU 124 6.599 46.877 11.259 1.00 0.32 1SG 1005
ATOM 1005 CB LEU 124 6.814 45.787 10.192 1.00 0.32 1SG 1006 ATOM
1006 CG LEU 124 5.515 45.183 9.624 1.00 0.32 1SG 1007 ATOM 1007 CD2
LEU 124 4.590 44.673 10.739 1.00 0.32 1SG 1008 ATOM 1008 CD1 LEU
124 5.817 44.105 8.571 1.00 0.32 1SG 1009 ATOM 1009 C LEU 124 7.971
47.343 11.640 1.00 0.32 1SG 1010 ATOM 1010 O LEU 124 8.523 48.248
11.017 1.00 0.32 1SG 1011 ATOM 1011 N GLN 125 8.543 46.757 12.714
1.00 0.33 1SG 1012 ATOM 1012 CA GLN 125 9.913 47.045 13.032 1.00
0.33 1SG 1013 ATOM 1013 CB GLN 125 10.152 47.788 14.359 1.00 0.33
1SG 1014 ATOM 1014 CG GLN 125 9.779 47.001 15.612 1.00 0.33 1SG
1015 ATOM 1015 CD GLN 125 10.320 47.768 16.812 1.00 0.33 1SG 1016
ATOM 1016 OE1 GLN 125 11.527 47.814 17.044 1.00 0.33 1SG 1017 ATOM
1017 NE2 GLN 125 9.403 48.390 17.600 1.00 0.33 1SG 1018 ATOM 1018 C
GLN 125 10.597 45.721 13.137 1.00 0.33 1SG 1019 ATOM 1019 O GLN 125
10.185 44.856 13.907 1.00 0.33 1SG 1020 ATOM 1020 N ASN 126 11.665
45.529 12.346 1.00 0.22 1SG 1021 ATOM 1021 CA ASN 126 12.397 44.297
12.359 1.00 0.22 1SG 1022 ATOM 1022 CB ASN 126 13.085 44.005 13.704
1.00 0.22 1SG 1023 ATOM 1023 CG ASN 126 14.202 45.024 13.875 1.00
0.22 1SG 1024 ATOM 1024 OD1 ASN 126 14.904 45.347 12.919 1.00 0.22
1SG 1025 ATOM 1025 ND2 ASN 126 14.369 45.551 15.118 1.00 0.22 1SG
1026 ATOM 1026 C ASN 126 11.473 43.162 12.041 1.00 0.22 1SG 1027
ATOM 1027 O ASN 126 11.685 42.036 12.491 1.00 0.22 1SG 1028 ATOM
1028 N GLY 127 10.420 43.428 11.245 1.00 0.15 1SG 1029 ATOM 1029 CA
GLY 127 9.558 42.371 10.800 1.00 0.15 1SG 1030 ATOM 1030 C GLY 127
8.459 42.097 11.784 1.00 0.15 1SG 1031 ATOM 1031 O GLY 127 7.651
41.197 11.556 1.00 0.15 1SG 1032 ATOM 1032 N LYS 128 8.386 42.841
12.907 1.00 0.28 1SG 1033 ATOM 1033 CA LYS 128 7.305 42.595 13.827
1.00 0.28 1SG 1034 ATOM 1034 CB LYS 128 7.746 42.359 15.281 1.00
0.28 1SG 1035 ATOM 1035 CG LYS 128 6.576 41.990 16.198 1.00 0.28
1SG 1036 ATOM 1036 CD LYS 128 6.996 41.432 17.558 1.00 0.28 1SG
1037 ATOM 1037 CE LYS 128 7.294 42.514 18.598 1.00 0.28 1SG 1038
ATOM 1038 NZ LYS 128 7.675 41.886 19.883 1.00 0.28 1SG 1039 ATOM
1039 C LYS 128 6.427 43.808 13.822 1.00 0.28 1SG 1040 ATOM 1040 O
LYS 128 6.920 44.933 13.880 1.00 0.28 1SG 1041 ATOM 1041 N ASP 129
5.092 43.604 13.758 1.00 0.47 1SG 1042 ATOM 1042 CA ASP 129 4.182
44.713 13.654 1.00 0.47 1SG 1043 ATOM 1043 CB ASP 129 2.781 44.323
13.141 1.00 0.47 1SG 1044 ATOM 1044 CG ASP 129 2.148 43.334 14.108
1.00 0.47 1SG 1045 ATOM 1045 OD1 ASP 129 2.903 42.693 14.887 1.00
0.47 1SG 1046 ATOM 1046 OD2 ASP 129 0.896 43.199 14.070 1.00 0.47
1SG 1047 ATOM 1047 C ASP 129 4.040 45.423 14.964 1.00 0.47 1SG 1048
ATOM 1048 O ASP 129 3.732 44.821 15.991 1.00 0.47 1SG 1049 ATOM
1049 N ARG 130 4.370 46.733 14.954 1.00 0.54 1SG 1050 ATOM 1050 CA
ARG 130 4.239 47.624 16.073 1.00 0.54 1SG 1051 ATOM 1051 CB ARG 130
5.171 48.845 15.964 1.00 0.54 1SG 1052 ATOM 1052 CG ARG 130 5.312
49.632 17.271 1.00 0.54 1SG 1053 ATOM 1053 CD ARG 130 4.047 50.382
17.689 1.00 0.54 1SG 1054 ATOM 1054 NE ARG 130 4.325 51.062 18.984
1.00 0.54 1SG 1055 ATOM 1055 CZ ARG 130 3.388 51.032 19.976 1.00
0.54 1SG 1056 ATOM 1056 NH1 ARG 130 2.230 50.330 19.800 1.00 0.54
1SG 1057 ATOM 1057 NH2 ARG 130 3.612 51.697 21.147 1.00 0.54 1SG
1058 ATOM 1058 C ARG 130 2.835 48.152 16.192 1.00 0.54 1SG 1059
ATOM 1059 O ARG 130 2.308 48.302 17.293 1.00 0.54 1SG 1060 ATOM
1060 N LYS 131 2.196 48.478 15.048 1.00 0.34 1SG 1061 ATOM 1061 CA
LYS 131 0.921 49.141 15.109 1.00 0.34 1SG 1062 ATOM 1062 CB LYS 131
1.106 50.668 15.097 1.00 0.34 1SG 1063 ATOM 1063 CG LYS 131 -0.168
51.511 15.150 1.00 0.34 1SG 1064 ATOM 1064 CD LYS 131 0.143 53.009
15.235 1.00 0.34 1SG 1065 ATOM 1065 CE LYS 131 -1.058 53.916 14.962
1.00 0.34 1SG 1066 ATOM 1066 NZ LYS 131 -0.665 55.338 15.068 1.00
0.34 1SG 1067 ATOM 1067 C LYS 131 0.121 48.809 13.888 1.00 0.34 1SG
1068 ATOM 1068 O LYS 131 0.657 48.725 12.784 1.00 0.34 1SG 1069
ATOM 1069 N TYR 132 -1.202 48.610 14.067 1.00 0.18 1SG 1070 ATOM
1070 CA TYR 132 -2.078 48.392 12.952 1.00 0.18 1SG 1071 ATOM 1071
CB TYR 132 -2.580 46.941 12.832 1.00 0.18 1SG 1072 ATOM 1072 CG TYR
132 -3.692 46.919 11.840 1.00 0.18 1SG 1073 ATOM 1073 CD1 TYR 132
-3.441 46.903 10.488 1.00 0.18 1SG 1074 ATOM 1074 CD2 TYR 132
-4.999 46.936 12.267 1.00 0.18 1SG 1075 ATOM 1075 CE1 TYR 132
-4.474 46.888 9.581 1.00 0.18 1SG 1076 ATOM 1076 CE2 TYR 132 -6.037
46.920 11.364 1.00 0.18 1SG 1077 ATOM 1077 CZ TYR 132 -5.774 46.893
10.016 1.00 0.18 1SG 1078 ATOM 1078 OH TYR 132 -6.827 46.877 9.078
1.00 0.18 1SG 1079 ATOM 1079 C TYR 132 -3.270 49.277 13.136 1.00
0.18 1SG 1080 ATOM 1080 O TYR 132 -3.826 49.344 14.229 1.00 0.18
1SG 1081 ATOM 1081 N PHE 133 -3.674 50.009 12.073 1.00 0.16 1SG
1082 ATOM 1082 CA PHE 133 -4.842 50.847 12.146 1.00 0.16 1SG 1083
ATOM 1083 CB PHE 133 -4.561 52.324 12.491 1.00 0.16 1SG 1084 ATOM
1084 CG PHE 133 -4.409 52.420 13.969 1.00 0.16 1SG 1085 ATOM 1085
CD1 PHE 133 -3.262 51.996 14.596 1.00 0.16 1SG 1086 ATOM 1086 CD2
PHE 133 -5.424 52.951 14.731 1.00 0.16 1SG 1087 ATOM 1087 CE1 PHE
133 -3.140 52.090 15.962 1.00 0.16 1SG 1088 ATOM 1088 CE2 PHE 133
-5.307 53.049 16.097 1.00 0.16 1SG 1089 ATOM 1089 CZ PHE 133 -4.161
52.615 16.716 1.00 0.16 1SG 1090 ATOM 1090 C PHE 133 -5.527 50.820
10.821 1.00 0.16 1SG 1091 ATOM 1091 O PHE 133 -4.886 50.846 9.774
1.00 0.16 1SG 1092 ATOM 1092 N HIS 134 -6.869 50.736 10.828 1.00
0.26 1SG 1093 ATOM 1093 CA HIS 134 -7.547 50.719 9.569 1.00 0.26
1SG 1094 ATOM 1094 ND1 HIS 134 -9.410 47.923 9.166 1.00 0.26 1SG
1095 ATOM 1095 CG HIS 134 -9.255 48.944 10.077 1.00 0.26 1SG 1096
ATOM 1096 CB HIS 134 -9.039 50.378 9.697 1.00 0.26 1SG 1097 ATOM
1097 NE2 HIS 134 -9.537 46.998 11.184 1.00 0.26 1SG 1098 ATOM 1098
CD2 HIS 134 -9.334 48.361 11.304 1.00 0.26 1SG 1099 ATOM 1099 CE1
HIS 134 -9.576 46.782 9.881 1.00 0.26 1SG 1100 ATOM 1100 C HIS 134
-7.425 52.058 8.902 1.00 0.26 1SG 1101 ATOM 1101 O HIS 134 -7.150
52.143 7.709 1.00 0.26 1SG 1102 ATOM 1102 N HIS 135 -7.712 53.138
9.650 1.00 0.40 1SG 1103 ATOM 1103 CA HIS 135 -7.716 54.478 9.124
1.00 0.40 1SG 1104 ATOM 1104 ND1 HIS 135 -8.378 55.032 12.360 1.00
0.40 1SG 1105 ATOM 1105 CG HIS 135 -8.228 55.796 11.224 1.00 0.40
1SG 1106 ATOM 1106 CB HIS 135 -8.708 55.391 9.862 1.00 0.40 1SG
1107 ATOM 1107 NE2 HIS 135 -7.321 56.889 12.977 1.00 0.40 1SG 1108
ATOM 1108 CD2 HIS 135 -7.581 56.926 11.619 1.00 0.40 1SG 1109 ATOM
1109 CE1 HIS 135 -7.818 55.733 13.379 1.00 0.40 1SG 1110 ATOM 1110
C HIS 135 -6.411 55.226 9.122 1.00 0.40 1SG 1111 ATOM 1111 O HIS
135 -6.136 55.962 8.176 1.00 0.40 1SG 1112 ATOM 1112 N ASN 136
-5.579 55.078 10.177 1.00 0.34 1SG 1113 ATOM 1113 CA ASN 136 -4.497
56.015 10.365 1.00 0.34 1SG 1114 ATOM 1114 CB ASN 136 -4.255 56.339
11.847 1.00 0.34 1SG 1115 ATOM 1115 CG ASN 136 -3.317 57.529 11.904
1.00 0.34 1SG 1116 ATOM 1116 OD1 ASN 136 -2.170 57.400 12.325 1.00
0.34 1SG 1117 ATOM 1117 ND2 ASN 136 -3.806 58.715 11.451 1.00 0.34
1SG 1118 ATOM 1118 C ASN 136 -3.187 55.580 9.769 1.00 0.34 1SG 1119
ATOM 1119 O ASN 136 -2.653 54.518 10.075 1.00 0.34 1SG 1120 ATOM
1120 N SER 137 -2.651 56.454 8.892 1.00 0.23 1SG 1121 ATOM 1121 CA
SER 137 -1.429 56.362 8.136 1.00 0.23
1SG 1122 ATOM 1122 CB SER 137 -1.431 57.298 6.916 1.00 0.23 1SG
1123 ATOM 1123 OG SER 137 -2.479 56.939 6.028 1.00 0.23 1SG 1124
ATOM 1124 C SER 137 -0.202 56.706 8.943 1.00 0.23 1SG 1125 ATOM
1125 O SER 137 0.906 56.514 8.445 1.00 0.23 1SG 1126 ATOM 1126 N
ASP 138 -0.334 57.310 10.147 1.00 0.21 1SG 1127 ATOM 1127 CA ASP
138 0.853 57.763 10.837 1.00 0.21 1SG 1128 ATOM 1128 CB ASP 138
0.793 59.245 11.273 1.00 0.21 1SG 1129 ATOM 1129 CG ASP 138 -0.332
59.471 12.281 1.00 0.21 1SG 1130 ATOM 1130 OD1 ASP 138 -0.325
58.810 13.354 1.00 0.21 1SG 1131 ATOM 1131 OD2 ASP 138 -1.221
60.313 11.986 1.00 0.21 1SG 1132 ATOM 1132 C ASP 138 1.179 56.931
12.047 1.00 0.21 1SG 1133 ATOM 1133 O ASP 138 0.353 56.172 12.550
1.00 0.21 1SG 1134 ATOM 1134 N PHE 139 2.442 57.061 12.525 1.00
0.22 1SG 1135 ATOM 1135 CA PHE 139 2.972 56.316 13.635 1.00 0.22
1SG 1136 ATOM 1136 CB PHE 139 3.793 55.124 13.104 1.00 0.22 1SG
1137 ATOM 1137 CG PHE 139 4.421 54.316 14.186 1.00 0.22 1SG 1138
ATOM 1138 CD1 PHE 139 3.664 53.563 15.055 1.00 0.22 1SG 1139 ATOM
1139 CD2 PHE 139 5.792 54.273 14.287 1.00 0.22 1SG 1140 ATOM 1140
CE1 PHE 139 4.270 52.812 16.034 1.00 0.22 1SG 1141 ATOM 1141 CE2
PHE 139 6.404 53.523 15.263 1.00 0.22 1SG 1142 ATOM 1142 CZ PHE 139
5.640 52.793 16.141 1.00 0.22 1SG 1143 ATOM 1143 C PHE 139 3.858
57.225 14.441 1.00 0.22 1SG 1144 ATOM 1144 O PHE 139 4.645 57.992
13.885 1.00 0.22 1SG 1145 ATOM 1145 N HIS 140 3.748 57.165 15.789
1.00 0.24 1SG 1146 ATOM 1146 CA HIS 140 4.541 58.034 16.620 1.00
0.24 1SG 1147 ATOM 1147 ND1 HIS 140 1.861 59.659 15.668 1.00 0.24
1SG 1148 ATOM 1148 CG HIS 140 2.970 60.039 16.391 1.00 0.24 1SG
1149 ATOM 1149 CB HIS 140 3.716 59.128 17.321 1.00 0.24 1SG 1150
ATOM 1150 NE2 HIS 140 2.223 61.801 15.196 1.00 0.24 1SG 1151 ATOM
1151 CD2 HIS 140 3.178 61.350 16.090 1.00 0.24 1SG 1152 ATOM 1152
CE1 HIS 140 1.455 60.750 14.970 1.00 0.24 1SG 1153 ATOM 1153 C HIS
140 5.125 57.228 17.739 1.00 0.24 1SG 1154 ATOM 1154 O HIS 140
4.444 56.404 18.347 1.00 0.24 1SG 1155 ATOM 1155 N ILE 141 6.419
57.455 18.041 1.00 0.25 1SG 1156 ATOM 1156 CA ILE 141 7.045 56.791
19.144 1.00 0.25 1SG 1157 ATOM 1157 CB ILE 141 8.257 56.002 18.742
1.00 0.25 1SG 1158 ATOM 1158 CG2 ILE 141 8.889 55.427 20.020 1.00
0.25 1SG 1159 ATOM 1159 CG1 ILE 141 7.895 54.928 17.704 1.00 0.25
1SG 1160 ATOM 1160 CD1 ILE 141 9.116 54.309 17.023 1.00 0.25 1SG
1161 ATOM 1161 C ILE 141 7.531 57.873 20.052 1.00 0.25 1SG 1162
ATOM 1162 O ILE 141 8.477 58.587 19.723 1.00 0.25 1SG 1163 ATOM
1163 N PRO 142 6.892 58.036 21.175 1.00 0.43 1SG 1164 ATOM 1164 CA
PRO 142 7.352 59.024 22.107 1.00 0.43 1SG 1165 ATOM 1165 CD PRO 142
5.453 57.854 21.248 1.00 0.43 1SG 1166 ATOM 1166 CB PRO 142 6.139
59.430 22.947 1.00 0.43 1SG 1167 ATOM 1167 CG PRO 142 5.083 58.350
22.652 1.00 0.43 1SG 1168 ATOM 1168 C PRO 14.2 8.466 58.424 22.902
1.00 0.43 1SG 1169 ATOM 1169 O PRO 142 8.482 57.204 23.054 1.00
0.43 1SG 1170 ATOM 1170 N LYS 143 9.387 59.260 23.422 1.00 0.52 1SG
1171 ATOM 1171 CA LYS 143 10.473 58.801 24.241 1.00 0.52 1SG 1172
ATOM 1172 CB LYS 143 10.025 58.371 25.651 1.00 0.52 1SG 1173 ATOM
1173 CG LYS 143 9.356 59.483 26.461 1.00 0.52 1SG 1174 ATOM 1174 CD
LYS 143 10.243 60.707 26.696 1.00 0.52 1SG 1175 ATOM 1175 CE LYS
143 9.553 61.806 27.508 1.00 0.52 1SG 1176 ATOM 1176 NZ LYS 143
8.346 62.283 26.794 1.00 0.52 1SG 1177 ATOM 1177 C LYS 143 11.135
57.616 23.605 1.00 0.52 1SG 1178 ATOM 1178 O LYS 143 10.991 56.492
24.083 1.00 0.52 1SG 1179 ATOM 1179 N ALA 144 11.886 57.840 22.508
1.00 0.40 1SG 1180 ATOM 1180 CA ALA 144 12.533 56.758 21.817 1.00
0.40 1SG 1181 ATOM 1181 CB ALA 144 13.097 57.155 20.441 1.00 0.40
1SG 1182 ATOM 1182 C ALA 144 13.672 56.228 22.636 1.00 0.40 1SG
1183 ATOM 1183 O ALA 144 14.282 56.947 23.427 1.00 0.40 1SG 1184
ATOM 1184 N THR 145 13.981 54.926 22.444 1.00 0.44 1SG 1185 ATOM
1185 CA THR 145 15.003 54.249 23.191 1.00 0.44 1SG 1186 ATOM 1186
CB THR 145 14.400 53.346 24.239 1.00 0.44 1SG 1187 ATOM 1187 OG1
THR 145 13.520 54.104 25.056 1.00 0.44 1SG 1188 ATOM 1188 CG2 THR
145 15.497 52.747 25.138 1.00 0.44 1SG 1189 ATOM 1189 C THR 145
15.788 53.422 22.200 1.00 0.44 1SG 1190 ATOM 1190 O THR 145 15.482
53.410 21.010 1.00 0.44 1SG 1191 ATOM 1191 N LEU 146 16.840 52.724
22.675 1.00 0.63 1SG 1192 ATOM 1192 CA LEU 146 17.739 51.923 21.890
1.00 0.63 1SG 1193 ATOM 1193 CB LEU 146 18.871 51.319 22.739 1.00
0.63 1SG 1194 ATOM 1194 CG LEU 146 19.780 52.375 23.396 1.00 0.63
1SG 1195 ATOM 1195 CD2 LEU 146 21.044 51.733 23.988 1.00 0.63 1SG
1196 ATOM 1196 CD1 LEU 146 19.008 53.219 24.424 1.00 0.63 1SG 1197
ATOM 1197 C LEU 146 17.007 50.780 21.252 1.00 0.63 1SG 1198 ATOM
1198 O LEU 146 17.373 50.337 20.165 1.00 0.63 1SG 1199 ATOM 1199 N
LYS 147 15.970 50.250 21.924 1.00 0.64 1SG 1200 ATOM 1200 CA LYS
147 15.234 49.124 21.415 1.00 0.64 1SG 1201 ATOM 1201 CB LYS 147
14.155 48.611 22.381 1.00 0.64 1SG 1202 ATOM 1202 CG LYS 147 14.737
47.990 23.651 1.00 0.64 1SG 1203 ATOM 1203 CD LYS 147 15.708 46.838
23.378 1.00 0.64 1SG 1204 ATOM 1204 CE LYS 147 15.081 45.661 22.626
1.00 0.64 1SG 1205 ATOM 1205 NZ LYS 147 15.060 45.938 21.172 1.00
0.64 1SG 1206 ATOM 1206 C LYS 147 14.553 49.511 20.138 1.00 0.64
1SG 1207 ATOM 1207 O LYS 147 14.327 48.669 19.271 1.00 0.64 1SG
1208 ATOM 1208 N ASP 148 14.198 50.802 20.011 1.00 0.39 1SG 1209
ATOM 1209 CA ASP 148 13.491 51.371 18.897 1.00 0.39 1SG 1210 ATOM
1210 CB ASP 148 13.077 52.834 19.134 1.00 0.39 1SG 1211 ATOM 1211
CG ASP 148 11.977 52.847 20.187 1.00 0.39 1SG 1212 ATOM 1212 OD1
ASP 148 11.064 51.984 20.096 1.00 0.39 1SG 1213 ATOM 1213 OD2 ASP
148 12.030 53.724 21.090 1.00 0.39 1SG 1214 ATOM 1214 C ASP 148
14.314 51.324 17.639 1.00 0.39 1SG 1215 ATOM 1215 O ASP 148 13.763
51.464 16.551 1.00 0.39 1SG 1216 ATOM 1216 N SER 149 15.653 51.209
17.725 1.00 0.24 1SG 1217 ATOM 1217 CA SER 149 16.434 51.189 16.513
1.00 0.24 1SG 1218 ATOM 1218 CB SER 149 17.948 51.047 16.748 1.00
0.24 1SG 1219 ATOM 1219 OG SER 149 18.448 52.160 17.471 1.00 0.24
1SG 1220 ATOM 1220 C SER 149 16.031 49.996 15.702 1.00 0.24 1SG
1221 ATOM 1221 O SER 149 15.620 48.977 16.252 1.00 0.24 1SG 1222
ATOM 1222 N GLY 150 16.118 50.089 14.354 1.00 0.24 1SG 1223 ATOM
1223 CA GLY 150 15.795 48.914 13.596 1.00 0.24 1SG 1224 ATOM 1224 C
GLY 150 15.308 49.283 12.229 1.00 0.24 1SG 1225 ATOM 1225 O GLY 150
15.351 50.442 11.818 1.00 0.24 1SG 1226 ATOM 1226 N SER 151 14.819
48.268 11.485 1.00 0.20 1SG 1227 ATOM 1227 CA SER 151 14.351 48.492
10.149 1.00 0.20 1SG 1228 ATOM 1228 CB SER 151 14.691 47.344 9.185
1.00 0.20 1SG 1229 ATOM 1229 OG SER 151 16.099 47.212 9.061 1.00
0.20 1SG 1230 ATOM 1230 C SER 151 12.862 48.605 10.193 1.00 0.20
1SG 1231 ATOM 1231 O SER 151 12.174 47.715 10.692 1.00 0.20 1SG
1232 ATOM 1232 N TYR 152 12.327 49.722 9.661 1.00 0.35 1SG 1233
ATOM 1233 CA TYR 152 10.906 49.925 9.663 1.00 0.35 1SG 1234 ATOM
1234 CB TYR 152 10.463 51.277 10.254 1.00 0.35 1SG 1235 ATOM 1235
CG TYR 152 10.639 51.246 11.735 1.00 0.35 1SG 1236 ATOM 1236 CD1
TYR 152 11.873 51.440 12.314 1.00 0.35 1SG 1237 ATOM 1237 CD2 TYR
152 9.549 51.036 12.550 1.00 0.35 1SG 1238 ATOM 1238 CE1 TYR 152
12.015 51.412 13.682 1.00 0.35 1SG 1239 ATOM 1239 CE2 TYR 152 9.685
51.007 13.917 1.00 0.35 1SG 1240 ATOM 1240 CZ TYR 152 10.921 51.195
14.485 1.00 0.35 1SG 1241 ATOM 1241 OH TYR 152 11.068 51.168 15.887
1.00 0.35 1SG 1242 ATOM 1242 C TYR 152 10.384 49.868 8.258 1.00
0.35 1SG 1243 ATOM 1243 O TYR 152 11.039 50.319 7.319 1.00 0.35 1SG
1244 ATOM 1244 N PHE 153 9.174 49.282 8.100 1.00 0.75 1SG 1245 ATOM
1245 CA PHE 153 8.500 49.142 6.835 1.00 0.75 1SG 1246 ATOM 1246 CB
PHE 153 8.423 47.706 6.276 1.00 0.75 1SG 1247 ATOM 1247 CG PHE 153
9.717 46.992 6.083 1.00 0.75 1SG 1248 ATOM 1248 CD1 PHE 153 10.350
46.400 7.151 1.00 0.75 1SG 1249 ATOM 1249 CD2 PHE 153 10.267 46.861
4.828 1.00 0.75 1SG 1250 ATOM 1250 CE1 PHE 153 11.531 45.716 6.977
1.00 0.75 1SG 1251 ATOM 1251 CE2 PHE 153 11.445 46.177 4.647 1.00
0.75 1SG 1252 ATOM 1252 CZ PHE 153 12.083 45.607 5.724 1.00 0.75
1SG 1253 ATOM 1253 C PHE 153 7.044 49.335 7.134 1.00 0.75 1SG 1254
ATOM 1254 O PHE 153 6.626 49.319 8.292 1.00 0.75 1SG 1255 ATOM 1255
N CYS 154 6.226 49.481 6.071 1.00 0.86 1SG 1256 ATOM 1256 CA CYS
154 4.807 49.626 6.230 1.00 0.86 1SG 1257 ATOM 1257 CB CYS 154
4.356 51.084 6.045 1.00 0.86 1SG 1258 ATOM 1258 SG CYS 154 2.557
51.224 5.915 1.00 0.86 1SG 1259 ATOM 1259 C CYS 154 4.117 48.817
5.167 1.00 0.86 1SG 1260 ATOM 1260 O CYS 154 4.680 48.544 4.108
1.00 0.86 1SG 1261 ATOM 1261 N ARG 155 2.870 48.380 5.451 1.00 0.56
1SG 1262 ATOM 1262 CA ARG 155 2.050 47.690 4.499 1.00 0.56 1SG 1263
ATOM 1263 CB ARG 155 1.825 46.206 4.836 1.00 0.56 1SG 1264 ATOM
1264 CG ARG 155 3.105 45.370 4.777 1.00 0.56 1SG 1265 ATOM 1265 CD
ARG 155 2.895 43.891 5.109 1.00 0.56 1SG 1266 ATOM 1266 NE ARG 155
2.510 43.797 6.545 1.00 0.56 1SG 1267 ATOM 1267 CZ ARG 155 1.952
42.646 7.022 1.00 0.56 1SG 1268 ATOM 1268 NH1 ARG 155 1.743 41.593
6.180 1.00 0.56 1SG 1269 ATOM 1269 NH2 ARG 155 1.603 42.548 8.338
1.00 0.56 1SG 1270 ATOM 1270 C ARG 155 0.716 48.370 4.543 1.00 0.56
1SG 1271 ATOM 1271 O ARG 155 0.343 48.942 5.569 1.00 0.56 1SG 1272
ATOM 1272 N GLY 156 -0.028 48.351 3.416 1.00 0.35 1SG 1273 ATOM
1273 CA GLY 156 -1.322 48.985 3.400 1.00 0.35 1SG 1274 ATOM 1274 C
GLY 156 -2.002 48.644 2.110 1.00 0.35 1SG 1275 ATOM 1275 O GLY 156
-1.354 48.263 1.135 1.00 0.35 1SG 1276 ATOM 1276 N LEU 157 -3.344
48.794 2.057 1.00 0.37 1SG 1277 ATOM 1277 CA LEU 157 -4.007 48.431
0.841 1.00 0.37 1SG 1278 ATOM 1278 CB LEU 157 -5.300 47.603 1.002
1.00 0.37 1SG 1279 ATOM 1279 CG LEU 157 -6.616 48.389 1.183 1.00
0.37 1SG 1280 ATOM 1280 CD2 LEU 157 -6.549 49.386 2.345 1.00 0.37
1SG 1281 ATOM 1281 CD1 LEU 157 -7.805 47.425 1.325 1.00 0.37 1SG
1282 ATOM 1282 C LEU 157 -4.334 49.668 0.075 1.00 0.37 1SG 1283
ATOM 1283 O LEU 157 -4.844 50.650 0.612 1.00 0.37 1SG 1284 ATOM
1284 N VAL 158 -3.984 49.648 -1.223 1.00 0.25 1SG 1285 ATOM 1285 CA
VAL 158 -4.299 50.717 -2.117 1.00 0.25 1SG 1286 ATOM 1286 CB VAL
158 -3.125 51.171 -2.929 1.00 0.25 1SG 1287 ATOM 1287 CG1 VAL 158
-3.625 52.124 -4.027 1.00 0.25 1SG 1288 ATOM 1288 CG2 VAL 158
-2.088 51.796 -1.981 1.00 0.25 1SG 1289 ATOM 1289 C VAL 158 -5.279
50.130 -3.065 1.00 0.25 1SG 1290 ATOM 1290 O VAL 158 -4.985 49.143
-3.738 1.00 0.25 1SG 1291 ATOM 1291 N GLY 159 -6.481 50.718 -3.149
1.00 0.14 1SG 1292 ATOM 1292 CA GLY 159 -7.440 50.118 -4.018 1.00
0.14 1SG 1293 ATOM 1293 C GLY 159 -7.690 48.744 -3.486 1.00 0.14
1SG 1294 ATOM 1294 O GLY 159 -8.016 48.562 -2.315 1.00 0.14 1SG
1295 ATOM 1295 N SER 160 -7.597 47.751 -4.385 1.00 0.21 1SG 1296
ATOM 1296 CA SER 160 -7.836 46.363 -4.117 1.00 0.21 1SG 1297 ATOM
1297 CB SER 160 -8.189 45.585 -5.397 1.00 0.21 1SG 1298 ATOM 1298
OG SER 160 -9.399 46.082 -5.951 1.00 0.21 1SG 1299 ATOM 1299 C SER
160 -6.697 45.631 -3.469 1.00 0.21 1SG 1300 ATOM 1300 O SER 160
-6.940 44.695 -2.707 1.00 0.21 1SG 1301 ATOM 1301 N LYS 161 -5.428
45.995 -3.753 1.00 0.33 1SG 1302 ATOM 1302 CA LYS 161 -4.384 45.112
-3.306 1.00 0.33 1SG 1303 ATOM 1303 CB LYS 161 -3.423 44.675 -4.426
1.00 0.33 1SG 1304 ATOM 1304 CG LYS 161 -4.077 43.773 -5.475 1.00
0.33 1SG 1305 ATOM 1305 CD LYS 161 -3.228 43.568 -6.732 1.00 0.33
1SG 1306 ATOM 1306 CE LYS 161 -2.135 42.511 -6.567 1.00 0.33 1SG
1307 ATOM 1307 NZ LYS 161 -1.386 42.355 -7.833 1.00 0.33 1SG 1308
ATOM 1308 C LYS 161 -3.550 45.700 -2.217 1.00 0.33 1SG 1309 ATOM
1309 O LYS 161 -3.514 46.909 -1.998 1.00 0.33 1SG 1310 ATOM 1310 N
ASN 162 -2.847 44.800 -1.499 1.00 0.32 1SG 1311 ATOM 1311 CA ASN
162 -1.996 45.168 -0.406 1.00 0.32 1SG 1312 ATOM 1312 CB ASN 162
-1.860 44.057 0.653 1.00 0.32 1SG 1313 ATOM 1313 CG ASN 162 -0.975
44.545 1.794 1.00 0.32 1SG 1314 ATOM 1314 OD1 ASN 162 0.206 44.834
1.613 1.00 0.32 1SG 1315 ATOM 1315 ND2 ASN 162 -1.568 44.637 3.015
1.00 0.32 1SG 1316 ATOM 1316 C ASN 162 -0.634 45.444 -0.958 1.00
0.32 1SG 1317 ATOM 1317 O ASN 162 -0.169 44.764 -1.872 1.00 0.32
1SG 1318 ATOM 1318 N VAL 163 0.037 46.480 -0.419 1.00 0.27 1SG 1319
ATOM 1319 CA VAL 163 1.352 46.811 -0.881 1.00 0.27 1SG 1320 ATOM
1320 CB VAL 163 1.412 48.149 -1.564 1.00 0.27 1SG 1321 ATOM 1321
CG1 VAL 163 2.865 48.442 -1.971 1.00 0.27 1SG 1322 ATOM 1322 CG2
VAL 163 0.427 48.136 -2.746 1.00 0.27 1SG 1323 ATOM 1323 C VAL 163
2.256 46.869 0.311 1.00 0.27 1SG 1324 ATOM 1324 O VAL 163 1.803
47.074 1.437 1.00 0.27 1SG 1325 ATOM 1325 N SER 164 3.568 46.644
0.088 1.00 0.29 1SG 1326 ATOM 1326 CA SER 164 4.521 46.731 1.157
1.00 0.29 1SG 1327 ATOM 1327 CB SER 164 5.214 45.401 1.489 1.00
0.29 1SG 1328 ATOM 1328 OG SER 164 6.044 45.006 0.409 1.00 0.29 1SG
1329 ATOM 1329 C SER 164 5.591 47.688 0.728 1.00 0.29 1SG 1330 ATOM
1330 O SER 164 5.981 47.717 -0.438 1.00 0.29 1SG 1331 ATOM 1331 N
SER 165 6.086 48.513 1.672 1.00 0.20 1SG 1332 ATOM 1332 CA SER 165
7.106 49.478 1.365 1.00 0.20 1SG 1333 ATOM 1333 CB SER 165 7.030
50.750 2.228 1.00 0.20 1SG 1334 ATOM 1334 OG SER 165 7.351 50.442
3.577 1.00 0.20 1SG 1335 ATOM 1335 C SER 165 8.449 48.865 1.616
1.00 0.20 1SG 1336 ATOM 1336 O SER 165 8.562 47.791 2.206 1.00 0.20
1SG 1337 ATOM 1337 N GLU 166 9.514 49.538 1.134 1.00 0.24 1SG 1338
ATOM 1338 CA GLU 166 10.849 49.081 1.386 1.00 0.24 1SG 1339 ATOM
1339 CB GLU 166 11.899 49.631 0.405 1.00 0.24 1SG 1340 ATOM 1340 CG
GLU 166 11.737 49.101 -1.022 1.00 0.24 1SG 1341 ATOM 1341 CD GLU
166 12.830 49.716 -1.884 1.00 0.24 1SG 1342 ATOM 1342 OE1 GLU 166
14.005 49.735 -1.432 1.00 0.24 1SG 1343 ATOM 1343 OE2 GLU 166
12.500 50.180 -3.009 1.00 0.24 1SG 1344 ATOM 1344 C GLU 166 11.199
49.563 2.758 1.00 0.24 1SG 1345 ATOM 1345 O GLU 166 10.560 50.471
3.286 1.00 0.24 1SG 1346 ATOM 1346 N THR 167 12.223 48.948 3.382
1.00 0.37 1SG 1347 ATOM 1347 CA THR 167 12.579 49.311 4.726 1.00
0.37 1SG 1348 ATOM 1348 CB THR 167 13.348 48.260 5.469 1.00 0.37
1SG 1349 ATOM 1349 OG1 THR 167 13.474 48.621 6.836 1.00 0.37 1SG
1350 ATOM 1350 CG2 THR 167 14.741 48.133 4.831 1.00 0.37 1SG 1351
ATOM 1351 C THR 167 13.464 50.514 4.734 1.00 0.37 1SG 1352 ATOM
1352 O THR 167 14.103 50.863 3.742 1.00 0.37 1SG 1353 ATOM 1353 N
VAL 168 13.478 51.191 5.899 1.00 0.32 1SG 1354 ATOM 1354 CA VAL 168
14.342 52.301 6.161 1.00 0.32 1SG 1355 ATOM 1355 CB VAL 168 13.619
53.606 6.332 1.00 0.32 1SG 1356 ATOM 1356 CG1 VAL 168 14.652 54.707
6.628 1.00 0.32 1SG 1357 ATOM 1357 CG2 VAL 168 12.777 53.870 5.071
1.00 0.32 1SG 1358 ATOM 1358 C VAL 168 14.985 51.983 7.477 1.00
0.32 1SG 1359 ATOM 1359 O VAL 168 14.311 51.562 8.417 1.00 0.32 1SG
1360 ATOM 1360 N ASN 169 16.315 52.167 7.582 1.00 0.27 1SG 1361
ATOM 1361 CA ASN 169 16.961 51.845 8.820 1.00 0.27 1SG 1362 ATOM
1362 CB ASN 169 18.405 51.332 8.659 1.00 0.27 1SG 1363 ATOM 1363 CG
ASN 169 19.251 52.419 8.010 1.00 0.27 1SG 1364 ATOM 1364 OD1 ASN
169 18.923 52.927 6.939 1.00 0.27 1SG 1365 ATOM 1365 ND2 ASN 169
20.374 52.794 8.680 1.00 0.27 1SG 1366 ATOM 1366 C ASN 169 16.998
53.089 9.640 1.00 0.27 1SG 1367 ATOM 1367 O ASN 169 17.465 54.135
9.191 1.00 0.27 1SG 1368 ATOM 1368 N ILE 170 16.466 52.999 10.872
1.00 0.18 1SG 1369 ATOM 1369 CA ILE 170 16.432 54.120 11.759 1.00
0.18 1SG 1370 ATOM 1370 CB ILE 170 15.039 54.499 12.169 1.00 0.18
1SG 1371 ATOM 1371 CG2 ILE 170 15.125 55.597 13.239 1.00 0.18 1SG
1372 ATOM 1372 CG1 ILE 170 14.219 54.903 10.933 1.00 0.18 1SG 1373
ATOM 1373 CD1 ILE 170 12.736 55.115 11.224 1.00 0.18 1SG 1374 ATOM
1374 C ILE 170 17.174 53.727 12.987 1.00 0.18 1SG 1375 ATOM 1375 O
ILE 170 16.957 52.654 13.549 1.00 0.18 1SG 1376 ATOM 1376 N THR 171
18.089 54.595 13.443 1.00 0.23 1SG 1377 ATOM 1377 CA THR 171 18.828
54.212 14.600 1.00 0.23 1SG 1378 ATOM 1378 CB THR 171 20.303 54.095
14.351 1.00 0.23 1SG 1379 ATOM 1379 OG1 THR 171 20.555 53.121
13.348 1.00 0.23 1SG 1380 ATOM 1380 CG2 THR 171 20.992 53.691
15.665 1.00 0.23 1SG 1381 ATOM 1381 C THR 171 18.633 55.238 15.658
1.00 0.23 1SG 1382 ATOM 1382 O THR 171 18.599 56.440 15.396 1.00
0.23 1SG 1383 ATOM 1383 N ILE 172 18.448 54.760 16.899 1.00 0.52
1SG 1384 ATOM 1384 CA ILE 172 18.446 55.666 17.987 1.00 0.52 1SG
1385 ATOM 1385 CB ILE 172 17.615 55.233 19.175 1.00 0.52 1SG 1386
ATOM 1386 CG2 ILE 172 18.032 53.833 19.655 1.00 0.52 1SG 1387 ATOM
1387 CG1 ILE 172 17.636 56.325 20.257 1.00 0.52 1SG 1388 ATOM 1388
CD1 ILE 172 16.588 56.119 21.349 1.00 0.52 1SG 1389 ATOM 1389 C ILE
172 19.882 55.716 18.301 1.00 0.52 1SG 1390 ATOM 1390 O ILE 172
20.463 54.767 18.833 1.00 0.52 1SG 1391 ATOM 1391 N THR 173 20.493
56.859 17.933
1.00 0.62 1SG 1392 ATOM 1392 CA THR 173 21.892 57.061 18.114 1.00
0.62 1SG 1393 ATOM 1393 CB THR 173 22.335 58.461 17.796 1.00 0.62
1SG 1394 ATOM 1394 OG1 THR 173 23.752 58.546 17.821 1.00 0.62 1SG
1395 ATOM 1395 CG2 THR 173 21.728 59.430 18.825 1.00 0.62 1SG 1396
ATOM 1396 C THR 173 22.118 56.823 19.551 1.00 0.62 1SG 1397 ATOM
1397 O THR 173 23.170 56.335 19.960 1.00 0.62 1SG 1398 ATOM 1398 N
GLN 174 21.099 57.144 20.363 1.00 0.51 1SG 1399 ATOM 1399 CA GLN
174 21.327 56.893 21.735 1.00 0.51 1SG 1400 ATOM 1400 CB GLN 174
20.192 57.355 22.657 1.00 0.51 1SG 1401 ATOM 1401 CG GLN 174 20.594
57.287 24.130 1.00 0.51 1SG 1402 ATOM 1402 CD GLN 174 21.508 58.471
24.408 1.00 0.51 1SG 1403 ATOM 1403 OE1 GLN 174 21.278 59.575
23.917 1.00 0.51 1SG 1404 ATOM 1404 NE2 GLN 174 22.579 58.237
25.212 1.00 0.51 1SG 1405 ATOM 1405 C GLN 174 21.464 55.387 21.896
1.00 0.51 1SG 1406 ATOM 1406 O GLN 174 20.520 54.662 21.485 1.00
0.51 1SG 1407 ATOM 1407 OXT GLN 174 22.513 54.940 22.435 1.00 0.51
1SG 1408 END
[0147] The following examples are provided for the purposes of
illustration and are not intended to limit the scope of the present
invention.
EXAMPLES
Example 1
[0148] This example describes the construction of a recombinant
baculovirus expressing soluble Fc.gamma.RIIa protein and the
production of such protein.
[0149] Recombinant molecule pFc.gamma.RIIa, containing a nucleic
acid molecule encoding a soluble form of human Fc.gamma.RII
(sFc.gamma.RIIa) operatively linked to baculovirus polyhedron
transcription control sequences was produced as follows. The
nucleic acid molecule sFc.gamma.RIIa was polymerase chain reaction
(PCR) amplified from about 10 nanogram (ng) of Fc.gamma.RIIa.sup.LR
cDNA (described in detail in Ierino, et al., J. Exp. Med., vol.
178, pp. 1617-1628, 1993) using about 100 ng of primer NR1 having
the nucleic acid sequence 5'-TAC GAA TTC CTA TGG AGA CCC AAA TGT
CTC-3' (denoted SEQ ID NO:l) and primer FI2 having the nucleic acid
sequence 5-CAT TCT AGA CTA TTG GAC AGT GAT GGT CAC-3' (denoted SEQ
ID NO:2), using standard PCR methods. The resulting PCR product is
510 base pairs (referred to herein as sFc.gamma.RIIa(a)) and
encodes the amino acid sequence represented herein by SEQ ID NO:3.
Based on the results obtained in the Mass Spectroscopy experiment
described in Example 7, a second protein product is present upon
expression of a recombinant molecule comprising a PCR product of
this Example. This data suggests that two PCR products were
produced from the present method. The second PCR product is
predicted to be 513 base pairs (referred to herein as
sFc.gamma.RIIa(b)) and encodes the amino acid sequence represented
herein by SEQ ID NO:12. The PCR products were digested with
restriction endonucleases EcoRI and XbaI and ligated into unique
EcoRI and XbaI sites of pVL1392 baculovirus shuttle plasmid
(available from Pharmingen, San Diego, Calif.) to produce
recombinant molecules referred to herein as pVL-sFc.gamma.RIIa(a)
and pVL-sFc.gamma.RIIa(b).
[0150] The recombinant molecules pVL-sFc.gamma.RIIa(a) and
pVL-sFc.gamma.RIIa(b) were co-transfected with baculovirus strain
AcMNPV (available from Pharmingen) into Spodoptera frugiperda 21
(Sf-21) cells (available from Invitrogen Corp., San Diego, Calif.)
to produce S. frugiperda:pVL-sFc.gamma.RIIa(a)/sFc.gamma.RIIa(b)
cells. Putative recombinant virus isolates were selected by
screening on X-galactosidase plates for occlusion of
b-galactosidase. Selected isolates were grown on monolayers of
Sf-21 cells for infection using serum-free Sf900-II media
(available from Gibco, New York) and the supernatant harvested
about 40 hours post-infection. The presence of recombinant protein,
referred to herein as PsFc.gamma.RIIa, in the supernatants was
determined by ELISA using anti-Fc.gamma.RII monoclonal antibodies
8.26 and 8.7 (described in detail in Ierino, et al., ibid.) using
standard methods. Based on the results described in Example 7,
recombinant protein PsFc.gamma.RIIa includes the two species of
protein having SEQ ID NO:3 and SEQ ID NO:12.
Example 2
[0151] This example describes the purification of PsFc.gamma.RIIa
for crystallization of the protein.
[0152] Supernatant from S. frugiperda:
pVL-sFc.gamma.RIIa(a)/sFc.gamma.RII- a(b) cells described above in
Example 1 was harvested and then centrifuged at about .times.2000
rpm to remove cellular debri. Supernatant from the centrifugation
was concentrated about five-fold using a Minitan.sup.a
ultrafiltration system (available from Millipore, Bedford, Mass.)
and then extensively dialyzed against a buffer containing 10 mM
Tris-HCl pH 8.5, and 50 mM NaCl. The dialyzed solution was applied
to a Q-Sepharose fast-flow ion exchange column (available from
Pharmacia, Uppsala, Sweden). The column was washed with 10 mM
Tris-HCl, pH 8.5, and then protein was eluted from the column using
a salt gradient from about of 0 to about 500 mM NaCl, passed over
the column over 4 hours. PsFc.gamma.RIIa was eluted from the column
at approximately 150 mM NaCl. The partially purified product was
dialyzed against a buffer containing 20 mM Tris-HCl pH 7.4, and 30
mM NaCl. The dialysate was applied to a HAGG immuno-affinity
chromatography column (described in detail in Ierino, et al.,
ibid.). The column was washed with a buffer containing 20 mM
Tris-HCl pH 7.4, and 30 mM NaCl. PsFc.gamma.RIIa was eluted from
the column using a buffer containing 0.1 M sodium acetate pH 4.0,
and 0.5 M NaCl. The eluant was neutralized using 3m Tris pH 8.0 and
the dialysed against PBS (3.5 mM NaH.sub.2PO.sub.42H.sub.2O, 16 mM
Na.sub.2HPO.sub.4, 150 mM NaCl). The dialysate was then
concentrated approximately fifty-fold using macro and nanosep-10
ultra-filtration concentration devices (available from Filtron,
Northborough, Mass.) and the applied to a G75 Superdex gel
filtration column equilibrated in PBS (available from Pharmacia,
Uppsala, Sweden). Filtered PsFc.gamma.RIIa was dialyzed against 1
mM Tris-HCl pH 7.4 and concentrated to about 6 milligram per
milliliter (mg/ml) of protein using macro and nanosep-10
ultra-filtration concentration devices. The purity of
PsFc.gamma.RIIa was assessed by resolving the concentrated protein
by SDS-PAGE and staining the protein with crocein scarlet.
[0153] An electronic scan of the resulting gel is shown in FIG. 1,
in which lane A contains supernatant harvested from a S.
frugiperda:pVL-sFc.gamma.RIIa(a)/sFc.gamma.RIIa(b) cell culture
prior to the ion-exchange step, lane B contains protein eluted from
the affinity column, lane C contains protein isolated from the gel
filtration chromatography step and lane D contains a sample of the
PsFc.gamma.RIIa concentrated to 6 mg/ml and that was used for
further crystallization studies. The molecular weight markers are
shown on the left side of the figure. The results indicate that the
purified PsFc.gamma.RIIa was about 90% pure with apparent molecular
weights of 25,000 daltons.
Example 3
[0154] This example describes two-dimensional non-equilibrium pH
gel electrophoresis analysis of purified PsFc.gamma.RIIa.
[0155] Supernatant from S.
frugiperda:pVL-sFc.gamma.RIIa(a)/sFc.gamma.RIIa- (b) was incubated
with about 20 microliter (ml) of packed Sepharose 4B beads
conjugated with F(ab') fragments of anti-Fc.gamma.RII monoclonal
antibody 8.26 (IgG2b) (the production of which is described in J.
Immunol., vol. 150, pp. 1-10, 1993) for about 1 hour at 4.degree.
C. The beads were then washed with buffer containing 10 mM Tris-HCl
pH 7.4, 2% wt/vol bovine serum albumin (available from Commonwealth
Serum Laboratories, Melbourne, Australia), 1 mM PMSF (available
from Sigma Chemical Co., St. Louis, Mo.), 0.1% vol/vol Aprotinin
(available from Sigma Chemical Co.), and then with 10 mM Tris-HCl,
pH 7.4. The beads were resuspended in about 50 ml isoelectric
focusing denaturation buffer (9.5 M urea, 4% acrylamide, 2% wt/vol
NP-40, 2% total ampholines and 50 mM dithiothreitol), spun at about
.times.13,000 rpm for about 2 minutes, loaded onto 4% tube gels and
overlaid with about 10 ml of overlay buffer (9 M urea, 1% total
ampholines) and anode buffer (0.01 M phosphoric acid), and
electrophoresed for about 5 hours at about 550 Volts. The gels were
then removed from the glass tubes, equilibrated in SDS-PAGE sample
buffer (62.5 mM Tris-HCl, pH 6.8, 50 mM dithiothreitol and 10%
glycerol) for about 2 hours at room temperature and attached to the
top of a 13% slab gel for SDS-PAGE.
[0156] The electrophoresed proteins were transferred to Immobilon-P
PVDF membrane (available from Millipore) using a semi-dry transfer
cell (Biorad, Australia) under a 20 mA current for about 30
minutes. The membrane was blocked in PBS buffer containing 5%
wt/vol skim milk for about 1 hour. The membrane was then incubated
overnight with a rabbit anti-Fc.gamma.RII polyclonal antisera
(diluted 1:10,000 in PBS containing 5% wt/vol skim milk) and then
washed extensively with buffer (10 mM Tris-HCl, pH 8.0, 150 mM
NaCl, 0.05% Tween-20). The polyclonal antisera was raised in
rabbits by immunization with recombinant Fc.gamma.RII protein. The
animals were immunized with about 1 mg of Fc.gamma.RII protein. For
the first immunization, Fc.gamma.RII protein was emulsified in
complete Freunds adjuvant. Subsequent immunizations were performed
using Fc.gamma.RII protein emulsified in incomplete Freunds
adjuvant. The membrane was then incubated with peroxidase-linked
swine anti-rabbit antisera (available from Dako Corp., Denmark)
(diluted 1:5000 in 10 mM Tris-HCl, pH 8.0, 150 mM NaCl and 0.05%
Tween-20) for about 1 hour at room temperature. The membrane was
washed before detection of the transferred protein using the
enhanced chemiluminescence system (available from Amersham
International, Australia). An electronic scan of the resulting gels
are shown in FIGS. 2A and 2B. FIG. 2A illustrates the migration of
protein isolated from supernatant harvested from S.
frugiperda:pVL-sFc.gamma.RIIa(a)/sFc.gamma.RIIa(b) cell cultures
after 34 hours. FIG. 2B illustrates the migration of protein
isolated from supernatant harvested from S.
frugiperda:pVL-sFc.gamma.RIIa(a)/sFc.gamma.- RIIa(b) cell cultures
after 73 hours. The molecular weight markers are shown on the left
side of the figure. The results indicate that the purified
PsFc.gamma.RIIa has an apparent molecular weight of 25,000 daltons
and a pI at about pH 6.
Example 4
[0157] This example describes N-terminal peptide sequence of
PsFc.gamma.RIIa.
[0158] Amino acid sequencing of purified PsFc.gamma.RIIa described
in Example 2 using standard sequential Edman degradation method
using an Applied Biosystem 470A gas phase sequenator coupled to an
Applied Biosystem 130 separation system for automatic on-line
analysis of the first eight amino acids (available from Applied
Biosystems, CA). The n-terminal sequence was determined to be
Ala-Pro-Pro-Lys-Ala-Val-Leu-Lys (denoted as SEQ ID NO:4).
Example 5
[0159] This example describes the binding of PsFc.gamma.RIIa to
monomeric immunoglobulin.
[0160] Analysis of the interaction between PsFc.gamma.RIIa and
monomeric immunoglobulin was performed using a BIAcore.sup.a 2000
biosensor (available from Pharmacia Biotech, Uppsala, Sweden) at
about 22.degree. C. in Hepes buffered saline (HBS; 10 mM Hepes
[N-2-hydroxyethylpiperazine- -N'-2-ethanesulfonic acid, available
from Commonwealth Serum Laboratories, Parkville, Australia], pH
7.4, 150 mM NaCl, 3.4 mM EDTA and 0.005% Surfactant, available from
Pharmacia). About 4000 to about 6000 response units (RU) of
monomeric human immunoglobulin subclasses IgG1, IgG2, IgG3, and IgE
(50 .mu.g/ml of each) were covalently coupled to separate
carboxymethylated dextran surface of each CM5 sensor-chips
(available from BIAcore, Uppsala, Sweden) using a amine coupling
kit (available from BIAcore), according to manufacturer's methods.
A series of PsFc.gamma.RIIa concentrations (about 0.001 to about 1
mg/ml protein) was injected over each sensor-chip surface for about
1 minute at about 20 .mu.l/min followed by about 3 minute
dissociation phase. Following administration of the protein, the
immunoglobulin surface was regenerated on each chip using a buffer
containing 50 mM diethylamine pH 11.5, and 1 M NaCl. The
equilibrium dissociation constants (K.sub.D) for the interaction
between PsFc.gamma.RIIa and immunoglobulin were obtained by
non-linear curve fitting of a single site binding equation [Bound
RU=(B1.sub.max.multidot.C)/(K.sub.D1+C)]; or a two site binding
equation [Bound
RU=((B1.sub.max.multidot.C)/(K.sub.D1+C))+((B2.sub.max.multidot.C)-
/(K.sub.D2+C))], where (B1.sub.max refers to the maximum binding
capacity of the surface at site 1; B2.sub.max refers to the maximum
binding capacity of the surface at site 2; C refers to the
concentration of PsFc.gamma.RIIa) and by linear curve fitting to
Scatchard plots. Data points obtained from the IgE channels were
subtracted to correct for refractive index differences. Data points
between 50 and 60 seconds were averaged to obtain the amount of
PsFc.gamma.RIIa bound at equilibrium for each PsFc.gamma.RIIa
concentration.
[0161] To determine the specificity of the interaction between
PsFc.gamma.RIIa and immobilized immunoglobulin, the interaction
between PsFc.gamma.RIIa with monomeric immunoglobulin was inhibited
by the presence of excess monomeric IgG (Sandaglobulin, available
from Sandoz, Basel, Switzerland). Using a fixed, half maximal dose
of PsFc.gamma.RIIa (50 .mu.g/ml), increasing concentrations of
monomeric IgG (0 to 2 mg/ml IgG) were mixed with the
PsFc.gamma.RIIa, at about 22.degree. C. for about 1 hour before
passing the PsFc.gamma.RIIa over a sensor-chip surface coated with
IgG1.
[0162] The results indicated that the binding of PsFc.gamma.RIIa to
IgG3 and IgG1 was saturable over a broad range of protein
concentrations. The maximum response units per protein
concentration were plotted against the molar concentration of
protein and curve fitting analyses undertaken. The curve of best
fit suggests that there are two regions of PsFc.gamma.RIIa that
interact with IgG3. At 50% of the sites, the affinity for IgG3 was
about 2.7.times.10.sup.6M.sup.-1 and at the remaining 50% of the
sites the affinity was about 1.2.times.104 M.sup.-1 (FIG. 3A). The
interaction between PsFc.gamma.RIIa and IgG1 also occurred in two
regions but the interaction was different from IgG3. Moreover, at
about 90% of the ligand binding sites, the affinity of
PsFc.gamma.RIIa for IgG1 was about 2.1.times.10.sup.6M.sup.-1 and
at the remaining 10% of sites the affinity was about
2.3.times.10.sup.4M.sup.-1 (FIG. 3B). The interaction was specific
for PsFc.gamma.RIIa since a six-fold molar excess of IgG completely
inhibited binding of PsFc.gamma.RIIa to IgG. Analysis of IgG2
binding was also performed and a Kd value of about
8.times.10.sup.-5M.sup.-1 was obtained (FIG. 3C).
Example 6
[0163] This example describes crystallization and X-ray diffraction
of PsFc.gamma.RIIa.
[0164] A. Production of Crystalline PsFc.gamma.RIIa
[0165] A series of alternative buffers were used to attempt to
produce crystals of PsFc.gamma.RIIa by hanging drop vapor
diffusion. Table 6 summarizes the different mother-liquor
formulations used and the results obtained.
6TABLE 6 Mother-liquor conditions and results of crystallization
trial 3 mg/ml PsFc.gamma.RIIa. No. SALT BUFFER PRECIPITANT.sup.a pH
RESULT 1 0.2M Calcium Chloride 0.1 M Acetate 30% MPD 4.6 clear drop
2 -- -- 0.4M Na K Tartrate -- fine precipitation 3 -- -- 0.4M Amm.
Phosphate -- clear drop 4 -- 0.1M Tris 2.0M Amm. Sulphate 8.5 clear
drop 5 0.2M Sodium Citrate 0.1M Hepes 40% MPD 7.5 phase separation
6 0.2M Mg Chloride 0.1M Tris 30% PEG 4000 8.5 dried up 7 -- 0.1M
Cacodylate 1.4M Sodium Acetate 6.5 clear drop 8 0.2M Sodium Citrate
0.1M Cacodylate 30% Isopropanol 6.5 clear drop 9.sup.b 0.2M Amm.
Acetate 0.1M Sodium 30% PEG 4000 5.6 phase separation Citrate &
crystal 10 0.2M Amm. Acetate 0.1M Acetate 30% PEG 4000 4.6 clear
drop 11 -- 0.1M Citrate 1.0M Amm. Phophate 5.6 clear drop 12 0.2M
Mg Chloride 0.1M Hepes 30% Isopropanol 7.5 clear drop 13 0.2M
Sodium Citrate 0.1M Tris 30% PEG 400 8.5 phase separation 14 0.2M
Calcium Chloride 0.1M Hepes 28% PEG 400 7.5 precipitation 15 0.2M
Amm. Sulphate 0.1M Cacodylate 30% PEG 8000 6.5 precipitation
16.sup.c -- 0.1M Hepes 1.5M Lithium Sulphate 7.5 splinters 17 0.2M
Lithium Sulphate 0.1M Hepes 30% PEG 4000 7.5 phase separation 18
0.2M Mg Acetate 0.1M Cacodylate 20% PEG 8000 6.5 clear drop 19 0.2M
Amm. Acetate 0.1M Tris 30% Isopropanol 8.5 clear drop 20 0.2M Amm.
Sulphate 0.1M Acetate 25% PEG 4000 4.6 heavy precipitaion 21 0.2M
Mg Acetate 0.1M Cacodylate 30% MPD 6.5 fine precipitation 22 0.2M
Sodium Acetate 0.1M Tris 30% PEG 4000 8.5 fine precipitation 23
0.2M Mg Chloride 0.1M Hepes 30% PEG 400 7.5 skin over drop 24 0.2M
Calcium Chloride 0.1M Acetate 20% Isopropanol 4.6 clear drop
25.sup.d -- 0.1M Imidazole 1.0M Sodium Acetate 7.5 crystal 26 0.2M
Amm. Acetate 0.1M Citrate 30% MPD 5.6 clear drop 27 0.2M Sodium
Citrate 0.1M Hepes 20% Isopropanol 7.5 clear drop 28 0.2M Sodium
Acetate 0.1M Cacodylate 30% PEG 8000 6.5 clear drop 29 -- 0.1M
Hepes 0.8M Na K Tartrate 7.5 clear drop 30 0.2M Amm. Sulphate --
30% PEG 8000 -- precipitation 31 0.2M Amm. Sulphate -- 30% PEG 4000
-- precipitation 32 -- -- 2.0M Amm. Sulphate -- clear drop 33 -- --
4.0M Sodium Formate -- precipitation 34 -- 0.1M Acetate 2.0M Sodium
Formate 4.6 precipitation 35 -- 0.1M Hepes 2.0M Na K Phosphate 7.5
precipitation 36 -- 0.1M Tris 8% PEG 8000 8.5 precipitation 37 --
0.1M Acetate 8% PEG 4000 4.6 aggregation 38 -- 0.1M Hepes 1.4M Na
Citrate 7.5 heavy precipitation 39 -- 0.1M Hepes 2.0M Amm. Sulphate
2% 7.5 fine precipitation PEG 400 40 -- 0.1M Citrate 20% PEG 4000,
20% 5.6 fine aggregation Isopropanol 41 -- 0.1M Hepes 20% PEG 4000,
10% 7.5 clear drop Isopropanol 42 0.05M K Phosphate -- 20% PEG 8000
-- clear drop 43 -- -- 30% PEG 1500 -- clear drop 44 -- -- 0.2M Mg
Formate -- clear drop 45 0.2M Zn Acetate 0.1M Cacodylate 18% PEG
8000 6.5 heavy precipitation 46 0.2M Ca Acetate 0.1M Cacodylate 18%
PEG 8000 6.5 fine precipitation 47 -- 0.1M Acetate 2.0M Amm.
Sulphate 4.6 heavy precipitation 48 -- 0.1M Tris 2.0M Amm. Sulphate
8.5 fine precipitation 49 1.0M Li Sulphate -- 2% PEG 8000 -- Med
precipitation 50 1.0M Li Sulphate -- 15% PEG 8000 -- heavy
precipitation .sup.aFinal concentration of precipitant used to
achieve the result listed. .sup.bCondition 9 produced two crystals
in the single droplet. .sup.cCondition 16 produced a shower of
splinters that have arisen from numerous nucleation points within
the droplet. .sup.dCondition 25 produced an unusual crystal.
Numerous crystalline plates appear to be joined together to form
this crystal. X-ray diffraction analysis of this crystal was not
successful.
[0166] A rapid screening method (generally described in McPherson,
1982, In: Preparation and Analysis of Protein Crystals, 1982, pp.
94-97, John Wiley and Sons, pub.; and J. Crystal Growth, vol. 122,
pp. 161-167, 1992) was used. Briefly, hanging drop vapor diffusion
experiments were performed using 24-well culture plates. Droplets
(about 3 .mu.l) containing about 3 mg/ml of PsFc.gamma.RIIa in an
equal volume of a mother-liquor were suspended from siliconized
coverslips inverted into 24-well tissue culture plates well. The
droplets were equilibrated at about 22.degree. C. against about 1
ml mother-liquor. Controlled temperature incubation was performed
in chambers (available from Linbro Inc, distributed by ICN Inc,
Costa Mesa Calif.) at about 22.degree. C. Successful
PsFc.gamma.RIIa crystallization was performed using the
mother-liquor 0.2 M ammonium acetate, 0.1 M citrate pH 5.6 and 30%
PEG 4000, at 22.degree. C. for between about 3 to about 9 days, or
up to 9 months depending upon the purity and concentration of the
PsFc.gamma.RIIa, resulting in the production of orthorhombic
crystals.
[0167] Successful PsFc.gamma.RIIa crystallization was also
performed using the mother-liquor 0.1 M HEPES pH 7.5 with 1.5 M
lithium sulphate, at 22.degree. C. for between about 3 to about 9
days, or up to 9 months depending upon the purity and concentration
of the PsFc.gamma.RIIa, resulting in the production of a series of
rod-like splinters of defined structure. The rod-like splinters
were analyzed by X-ray diffraction.
[0168] B. X-ray Diffraction of Crystalline PsFc.gamma.RIIa and
Determination of Electron Density Map
[0169] The PsFc.gamma.RIIa crystals produced as described above in
section A were mounted in rayon loops and cryo-cooled to
-165.degree. C. in mother liquor containing 20% glycerol. Twelve
heavy atom compounds which sampled a broad range of activities were
tested for binding to PsFc.gamma.RIIa. PIP (Di-.mu.-iodo
bis[ethylenediamine] di Platinum(II) nitrate) was found to be
reactive. Crystals were derivatized by soaking overnight in mother
liquor containing about 5 mM PIP. Diffraction measurements were
made with a M18XHF rotating anode generator (Siemens, Germany)
operating at about 40 KV and about 50 mA and using Ni filtered
CuK.gamma. radiation. The generator was equipped with Franks
mirrors (Molecular Structure Corporation, USA), a low-temperature
system (Molecular Structure Corporation, USA) and RAXIS IIC and IV
image plate detectors (Rigaku, Japan).
[0170] The crystals belong to the space group P2.sub.12.sub.12
(a=78.80 .ANG., b=100.55 .ANG., c=27.85 .ANG.) and diffracted to
about 2.4 .ANG. resolution with an R(merge) of 0.065.
R(merge)=S(I.sub.i-(1S))/I.sub.i summed over all independent
reflections where I=intensity. Native and derivative data were
collected at 45 minute exposures with an oscillation range of about
1.degree.. Diffraction intensities were integrated using DENZO
(Otwinowski, et al., Methods in Enzymology, vol. 276, p. 307, 1996)
and scaled with SCALEPACK (Otwinowski, et al., ibid.). A single
heavy atom binding site was located by inspection of isomorphous
and anomalous difference Patterson maps (Blundell, et al., In:
Protein Crystallography., Horecker, B., Kaplan, N. O., Marmur, J.,
Scheraga, H. A., Eds., Academic Press, New York, 1976) calculated
with the PROTEIN system (Steigeman, Ph.D. Thesis, Technical
University, Munich, 1974). Heavy atom parameters were refined and
phases were determined in a method of Single Isomorphous
Replacement with Anomalous Scattering using the program SHARP
(Statistical Heavy-Atom Refinement and Phasing (de La Fortelle, et
al., Methods in Enzymology, vol. 276, p. 472, 1996). Merged data in
the range of about 18 to about 2.7 A resolution had an isomorphous
R-factor of about 0.162, figure of merit for centric reflections
0.308 and acentric reflections 0.247 and phasing power of 1.127 for
centric reflections and 1.081 for acentric reflections (Blundell,
ibid.). Phases were modified in a protocol of solvent flattening
(Wang, Methods in Enzymology, vol. 115, p. 90, 1985) and histogram
mapping (Zhang, et al., Acta Crystallography, vol. A46, p. 377,
1990) in the density modification package DM (Cowtan, Joint CCP4
and ESF-EACBM Newsletter on Protein Crystallography, vol. 31, p.
34, 1994) in the CCP4 suite of programs (Cowtan, ibid.). 2Fo-Fc
electron-density maps were displayed using the graphical display
program O (Jones et. al., Acta Crystallography, vol. A47, p. 110,
1991). Secondary structural features could be identified at this
stage, however the map was difficult to fully interpret and trace
of the polypeptide. To produce a simplified representation of the
electron density, the map was skeletonised (Greer, J. Mol. Biol.,
vol. 82, p. 279, 1974) using the program BONES (Jones, et al.,
ibid.). Coordinates of Killer Inhibitory receptor (Fan, et. al.,
Nature, vol. 389, p. 96, 1997) and were used as a reference to
trace the polypeptide and generate a partial model. To calculate
subsequent maps density modified phases and phases calculated from
the model were combined by the Free-Sim method (Sim, Acta
Crystallography, vol. 13, p. 511, 1960).
[0171] Additional data for structure refinement were collected at
beam line X4A of the National Synchrotron Light Source at
Brookhaven National Laboratory (Upton, New York). Using radiation
with a wavelength of about 1.058 .ANG., data were collected on Fuji
image plates as exposures of about 100 seconds and oscillation
ranges of about 1.degree.. Diffraction images were digitized with a
BAS 2000 scanner (Fuji, Japan) and processed as described above,
giving an R(merge) of 0.038 for data between about 10 .ANG. and
about 1.7 .ANG. resolution. Structure refinement was performed with
the XPLOR system (Brunger, et al., Science, vol. 235, p. 458, 1987)
using protocols including individual temperature factor, energy
minimization and slow-cool simulated annealing refinement with bulk
solvent correction.
[0172] The refined structure of PsFc.gamma.RIIa contains all amino
acid residues from 1 to 170, together with 33 solvent molecules.
The crystallographic residual R-factor and Free R-factor are about
0.253 and about 0.326 respectively for data of from about 7 .ANG.
to about 2.0 .ANG. resolution (Brunger, 1987, ibid.). Root mean
squared deviations from ideality for bond lengths was about 0.01
.ANG. and about 1.45.degree. for angles (Brunger, et al., Nature,
vol. 355, p. 472, 1992). The resulting data set of the atomic
coordinates for PsFc.gamma.RIIa is shown in FIG. 4.
[0173] C. PsFc.gamma.RIIa Structure
[0174] Using the atomic coordinates listed in Table 1, a structure
of a dimer of PsFc.gamma.RIIa was derived. The structures were
computer generated using MOLSCRIPT 2.0 program (available from
Avatar Software AB, Heleneborgsgatan 21C, SE-11731 Stockholm,
Sweden). The crystal structure reveals PsFc.gamma.RIIa in a dimeric
form having two 170 amino acid monomers. The two monomers are
structurally identical.
[0175] The structure of the PsFc.gamma.RIIa residues 1 to 170
consists of two immunoglobulin constant region 2 (C2) type
immunoglobulin domains and each domain is comprised of two
antiparallel b-sheets, pinned together by a disulfide bond. The
first strand of each domain (A strand) is broken in the middle with
part forming sheet I (ABE strands) and part forming sheet II
(A'GFCC' strands). This structural feature occurs in immunoglobulin
variable region (V) type domains and in the natural killer
inhibitory receptor (KIR) but not in other C2 domains. The two
immunoglobulin-like domains of PsFc.gamma.RIIa are quite similar to
each other with the rms difference in Ca positions of 1.28 .ANG.
for 68 residues. Major differences are in the loops at the
N-terminal end of the molecule (BC, C'E and FG loops) and in the
position on the C' strand. Some of these loops have been implicated
in binding Fc.
[0176] The region of association of the two domains in the
PsFc.gamma.RIIa structure is quite bent, with the angle between the
major axes of the domains being approximately 52.degree.. This bend
is more severe than other immunoglobulin super family members
including 60.degree. for KIR. The domain interface is composed of
strands A' from Domain 1 and A & B from Domain 2, where sheet
II from each domain forms the interface. Residues whose
non-hydrogen atoms lie within 4 .ANG. of the other domain. Water
molecules 201, 211, 217-220, 227 and 232 also lie in the interface
region.
[0177] Certain structural characteristics indicate that dimer
formation between two PsFc.gamma.RIIa molecules in the crystal is a
preferred interaction. Although the structure of only one
PsFc.gamma.RIIa molecule (residues 1 to 170) of the crystal has
been determined, each PsFc.gamma.RIIa molecule comprising the dimer
in the crystal is related to the other PsFc.gamma.RIIa molecule in
the crystal by a 2-fold crystallographic axis. By applying the
transformation: 1 ( - 1 0 0 ) ( 0 - 1 0 ) ( 0 0 1 ) ( x ) ( y ) ( z
) + ( 0. ) ( 100.55 ) ( 0. )
[0178] to the coordinates given in Table 1 a dimer is formed (FIG.
4), with the interface composed of sheet II from each
PsFc.gamma.RIIa molecule. The coordinates of the Fc.gamma.RIIa
dimer are represented in Table 2. The contact area is substantial
(.about.400 .ANG..sup.2) and this interface has more hydrophobic
character than the Domain 1-Domain 2 interface. Residues whose
non-hydrogen atoms lie within 4 .ANG. of the other molecule or
water molecule 207 on the axis are 119, 121, 124-126, 150, 152 and
158-161, with residues 148, 163 and 164 also making a close
approach. This type of domain interaction is not novel for
immunoglobulins because V regions of antibodies pair in a similar
manner. This type of interaction, however, has not been observed
for C2 domains. Due to the size and character of this contact it
suggests that this hitherto unforeseen interaction has
physiological relevance.
[0179] Additional structural considerations support this
conclusion. The crystal structure described above suggests that, if
an Fc.gamma.RIIa molecule is oriented with the C-terminus toward a
cell membrane containing the receptor, then the putative Fc binding
region of the receptor does not point away from the cell but to one
side. Thus, forming a dimer between two Fc.gamma.RIIa molecules in
a cell membrane, the two potential Fc binding regions are brought
near each other and point away from the cell because the dimer axis
points away from the cell. This orientation positions the potential
Fc binding sites ideally for interaction with ligand (i.e., IgG),
enabling the ligand binding site to be composed of regions from two
receptor molecules. Involving two receptor molecules in a binding
event has implications for cellular signal transduction because
dimerization of the extracellular domains would bring the
cytoplasmic domains of the two receptors together to initiate a
cellular signal transduction response.
[0180] FIG. 4 shows a graphical representation of the dimer of
PFc.gamma.RIIa. Two Ig-like domains (Domains 1 and 2) are shown in
each monomer of each dimer. The first amino acid residue of the
amino (NH2) terminus of the protein is indicated by residue number
0. The last amino acid residue of the carboxyl (COOH) terminus of
the protein is indicated by residue 170. Numbering of amino acid
residues from the NH2 terminus to the COOH terminus are shown where
possible. Certain residues were omitted for clarity. FIG. 5
illustrates the amino acid residues that comprise each beta sheet
of Domain 1 and Domain 2 of PFc.gamma.RIIa. In Domain 1, strand A
includes residues 5-10, strand A' includes residues 14-17, strand B
includes residues 20-28, strand C includes residues 37-41, strand
C' includes residues 44-46, strand E includes residues 52-58,
strand F includes residues 63-70 and strand G includes residues
78-84. In Domain 2, strand A includes residues 87-92, strand A'
includes residues 95-97, strand B includes residues 102-110, strand
C includes residues 117-122, strand C' includes residues 125-131,
strand E includes residues 134-139, strand F includes residues
146-155, strand G includes residues 158-162 and strand G' includes
residues 163-169. FIG. 6 shows the stereo view of the structure of
the polypeptide shown in FIG. 4 in stereo.
[0181] A graphical representation of the three dimensional
structure shown in FIG. 4 was used to determine the location of
amino acid residues involved in the binding of Fc.gamma.RIIa to
IgG. FIG. 7 shows the location of the mutated alanine residues
(indicated by the black balls) involved in the loss of binding of
Fc.gamma.RIIa to IgG. The residues shown in FIG. 7 were identified
using recombinant mutants of Fc.gamma.RIIa, in which residues were
replaced with alanine and were found to disrupt or decrease IgG
binding to Fc.gamma.RIIa (described in Hulett, et al., 1994, ibid.;
Hulett, et al., 1995, ibid.). FIG. 8 shows an expanded view of the
IgG binding region showing position and side chains of amino acids
involved in IgG binding to Fc.gamma.RIIa, as shown by production of
nucleic acid molecules having mutations in this region that encode
an Fc.gamma.RIIa protein having reduced binding to IgG.
[0182] FIG. 9 shows an expanded view of the IgG binding region and
the amino acid residues, which when mutated to alanine, improve IgG
binding.
[0183] The interface between the two dimers illustrated in the
graphical representation of the three dimensional structure shown
in FIG. 4 was further analyzed. FIG. 10 shows an expanded view of
the region of one Fc.gamma.RIIa monomer that contributes to the
dimer interface. In FIG. 10, the region has been rotated about
90.degree. in x, where x is horizontal to the page. The .gamma.
carbon of amino acid residues contributing to the interface are
shown as black balls and are numbered according to the residue
numbering of SEQ ID NO:3.
Example 7
[0184] This example describes analysis of N-terminal sequence of
PsFc.gamma.RIIa protein by electrospray ionization mass
spectrometry.
[0185] To determine the N-terminal amino acid sequence of
PsFc.gamma.RIIa protein, the heterogeneity of the N-linked
glycosylation mass spectrometry was carried out as follows. Various
samples were prepared by combining about 1 to about 100 picomolar
(pmol) of PsFc.gamma.RIIa protein in about 2 .mu.l to about 4 .mu.l
of 50% CH.sub.3CN containing 0.1% acetic acid. The samples were
infused at a flow rate of about 0.2 .mu.l/min into a Perkin Elmer
Sciex API-300 triple quadrupole mass spectrometer fitted with a
micro-ionspray ion source and operated in the Q1 scan mode. The
mass scale was calibrated at eight points over the 3000 u mass
range, to an accuracy equivalent to .+-.0.01%, using singly charged
poly(propylene glycol) ions. Mass spectra (typically 30-100 scans)
were recorded over the mass rand m/z200 u to 3000 u with a constant
peak width of 0.6 u (peak width at half-height), and were processed
by signal-averaging, manual mass determination and transformation
using PE-Sciex Biomultiview software. The results indicated that
two major species of protein having different N-terminal sequence
were present in the solution of purified PsFc.gamma.RIIa protein.
One species had a N-terminal sequence comprising SEQ ID NO:4 and
the other species had a N-terminal sequence with an additional Ala
at the 5' end of the protein (e.g., Ala-Ala-Pro-).
Example 8
[0186] This example describes the modeling of the three dimensional
structure of the Fc.epsilon. receptor I (Fc.epsilon.RI) in both
monomeric and dimeric forms.
[0187] The extracellular regions of the human Fc epsilon receptor
type I (Fc.epsilon.RI) and the human Fc gamma Receptor type II a
(Fc.gamma.RIIa) show a sequence identity of about 38% (for 172
residues). The final sequence alignment used in this modeling work
is shown in FIG. 13. The X-ray crystallographic structure of the
human Fc.gamma.RIIa was determined by the present inventors (Table
1). The 3-dimensional coordinates of Fc.gamma.RIIa in Table 1
differ from those used as the template to build a 3-dimensional
model of the human Fc.epsilon.RI by orientation of the imidazole
ring of His 108 and one round of refinement.
[0188] Secondary structure prediction performed on Fc.epsilon.RI
confirmed the validity of the alignment given in FIG. 13 and showed
the pattern of .beta. strands is the same in both Fc.epsilon.RI and
Fc.gamma.RIIa. The secondary structure prediction methods used were
PHD (B. Rost et al., CABIOS, vol. 10, 266-275(1994)) and PREDATOR
(D. Frishman and P. Argos, Proteins, vol. 27, 329-335(1997)).
[0189] MODELER (A. Sali and T. L. Blundell, J. Mol. Biol., vol.
234, 779-815(1993)) as implemented in the InsightII_Homology
software package (Insight II (97.0), MSI, San Diego) was used to
generate 3-dimensional models of Fc.epsilon.RI using a number of
different initial sequence alignments and two structural templates
of Fc.gamma.RIIa. One of the structural templates was the
3-dimensional coordinates of Fc.gamma.RIIa where, for the residues
that had alternative side-chain conformations (residue numbers 10,
21, 33, 57, 60, 61, 65, and 89), the conformations labeled `A` were
selected while in the other template the conformations labeled `B`
were selected. In each Modeler run 5 structural models of
Fc.epsilon.RI were generated. The following parameter values or
options were used: `library_schedule` of 1, `max_var_iterations` of
300, `md_level` of `refine1`, `repeat_optimization` of 3, and
`max_molpdf` of 1e6. The best model from these runs had the
sequence alignment given in FIG. 13, and used the structural
template of Fc.gamma.RIIa, where residues 10, 21, 33, 57, 60, 61,
65, and 89 had side-chains in the `A` conformation. The criteria
for judging the `best` model included the lowest value of the
Modeler objective function (or -1.0.times.ln(Molecular probability
density function=Mpdf)), `well-behaved` PROSAII (M. Sippl,
Proteins, vol. 17, 355-362(1993)) residue energy plot for the model
(for example, negative residue energy scores throughout the
sequence), and `well-behaved` PROFILES-3D (J. U. Bowie et al.,
Science, vol. 253, 164-170(1991)) local 3D-1D compatibility score
plot (for example, positive plot scores throughout the
sequence).
[0190] Next, Modeler was used to generate 20 different structural
models of Fc.epsilon.RI using the sequence alignment and template
selected above, and using the parameter values and options listed
above. The model with the lowest -ln(Mpdf) value (i.e. 957.2) was
then selected as the template to generate structural models of the
Fc.epsilon.RI sequence in the next cycle of Modeler runs. At the
end of four such cycles, the `best` 3-dimensional model of the
Fc.epsilon.RI structure had a -ln(Mpdf) value of 643.2. This was
selected as the final structural model of the Fc.epsilon.RI
monomer, and the corresponding heavy (non-hydrogen) atom Cartesian
coordinates are represented in Table 3. A `worm` representation of
the structure is shown in FIG. 14. This structure was validated
with the programs PROSAII, PROFILES-3D, and PROCHECK (R. M.
Laskowski et al., J. Appl. Cryst. vol. 26, 283-291(1993)).
[0191] Finally, the same coordinate transformation that generates a
dimer from the Fc.gamma.RIIa monomer was applied to the above model
of the Fc.epsilon.RI monomer. The interface of the resultant dimer
was optimized by selecting alternative rotamers for the Glu 161 and
Tyr 150 residues with the Auto_Rotamer option of the
InsightII_Homology module (MSI, San Diego), and then adding
hydrogen atoms to the dimer model and energy minimizing it keeping
all heavy atoms fixed, except for Tyr 150 and Glu 161 where only
the backbone atoms were kept fixed. The program Discover v. 2.98
(MSI, San Diego) was used for the energy minimization with the
CFF91 force field and a distance-dependent dielectric constant of
1.0.times.r, and the minimization was done with the conjugate
gradients method until the maximum energy gradient was less than
0.10 kcal/.ANG.. The Cartesian coordinates of the resultant model
of the Fc.epsilon.RI dimer are represented in Table 4 and a `worm`
representation of the dimer model is shown in FIG. 15. This model
of the Fc.epsilon.RI dimer has a shape complementarity or Sc
value(see M. C. Lawrence and P. M. Colman, J. Mol. Biol., vol. 234,
946-950(1993)) at the monomer-monomer interface of 0.64 and an
electrostatic complementarity value--for the fully solvated case,
using the Spearman correlation coefficient--(see A. J. McCoy, V. C.
Epa, and P. M. Colman, J. Mol. Biol., vol. 268, 570-584(1997)) or
ECSFS at the monomer-monomer interface of 0.08. These compare with
0.80 and 0.32, respectively, for the Fc.gamma.RIIa dimer. These
reduced complementarity values for the Fc.epsilon.RI dimer compared
to the Fc.gamma.RIIa dimer indicates that formation of the
Fc.epsilon.RI dimer, as built herein, is energetically less favored
than it is in the Fc.gamma.RIIa case. However, we note that the
interaction with the .beta. or .gamma. chains of the Fc.epsilon.RI
has not been taken into consideration. FIG. 16 shows a molecular
surface representation of the Fc.epsilon.RI dimer model.
[0192] The model of the 3-dimensional structure of Fc.epsilon.RI
monomer represented by the coordinates in Table 3 or the
Fc.epsilon.RI dimer represented by the coordinates in Table 4 may
be used as a basis for drug design in the same manner as that
described for the crystallographic coordinates of Fc.gamma.RIIa
herein.
Example 9
[0193] The following example demonstrates the crystallization of
the Fc.epsilon. receptor I (Fc.epsilon.RI).
[0194] Recombinant molecule pFc.epsilon.RI, containing a nucleic
acid molecule encoding a soluble form of human Fc.epsilon.RI
(sFc.epsilon.RI) operatively linked to baculovirus polyhedron
transcription control sequences was produced as described for the
pFc.gamma.RIIa molecule in Examples 1-3. Briefly, the recombinant
soluble Fc.epsilon.RI was generated by placing a translation
termination codon at the position 173 which normally encodes a Pro
in the sequence Ile, Lys, Ala, Pro, at the C-terminal end of the
second domain as set forth in the sequence represented in FIG. 13.
Soluble Fc.epsilon.RI was expressed in baculovirus expression
system `Bac to Bac` supplied by GIBCO. Infections of SF21 or Sf9
cells were performed as described by the manufacturer. Briefly, the
recombinant Fc.gamma.RIIa molecule was ligated into pVL1392
baculovirus shuttle plasmid (available from Pharmingen, San Diego,
Calif.) to produce a recombinant molecule referred to herein as
pVL-sFc.epsilon.RI. The recombinant molecule pVL-sFc.epsilon.RI was
subsequently co-transfected with baculovirus strain AcMNPV
(available from Pharmingen) into Spodoptera frugiperda 21 (Sf-21)
cells (available from Invitrogen Corp., San Diego, Calif.) to
produce S. frugiperda:pVL-sFc.epsilon.RI cells. 65-70 hours
following infection, supernatants were harvested and soluble
receptor was purified by affinity chromatography on an
anti-Fc.epsilon.RI antibody (3B4) monoclonal antibody-sepharose 4B
affinity column, similar to the processes described for
Fc.gamma.RIIa in Example 5. The column was washed with 10 mM Tris
pH 7.5 and eluted with 0.1 M sodium acetate, 0.5M sodium chloride,
pH 4.0. The purified protein was concentrated and used in
crystallization trials as described above for Fc.gamma.RIIa
(Example 6). Crystals were produced under several conditions as
follows:
[0195] (a) 0.2M calcium acetate; 0.1M sodium cacodylate, pH 6.5;
18% w/v polyethylene glycol (PEG) 8000;
[0196] (b) 0.1M sodium cacodylate, pH 6.0 or pH 5.5; 10% v/v
2-propanol; 20% w/v PEG 4000;
[0197] (c) 0.2M tri sodium citrate dihydrate; 0.1M sodium
cacodylate pH 6.5; 30% v/v 2-propanol.
[0198] The structure of the Fc.epsilon.RI crystals obtained by
these experiments can be used in X-ray diffraction analysis and/or
in molecular replacement and modeling strategies as described
herein.
Example 10
[0199] This example describes the modeling of the three dimensional
structure of the Fc.gamma. receptor III (Fc.gamma.RIIIb) in
monomeric form.
[0200] The extracellular regions of the human Fc gamma receptor
type III (Fc.gamma.RIIIb) and the human Fc gamma Receptor type II a
(Fc.gamma.RIIa) show a sequence identity of about 53% (for 174
residues). The final sequence alignment used in this modeling work
is shown in FIG. 18. The X-ray crystallographic structure of the
human Fc.gamma.RIIa was determined by the present inventors (Table
1) as described in Examples 1-7. The 3-dimensional coordinates of
Fc.gamma.RIIa in Table 1 differ from those used as the template to
build a 3-dimensional model of the human Fc.gamma.RIIIb by
orientation of the imidazole ring of His 108 and one round of
refinement.
[0201] MODELER (A. Sali and T. L. Blundell, J. Mol. Biol., vol.
234, 779-815(1993)) as implemented in the InsightII_Homology
software package (Insight II (97.0), MSI, San Diego) was used to
generate 3-dimensional models of Fc.gamma.RIIIb using a number of
different initial sequence alignments and two structural templates
of Fc.gamma.RIIa. The structural template that was used was the
3-dimensional coordinates of Fc.gamma.RIIa where, for the residues
that had alternative side-chain conformations (residue numbers 10,
21, 33, 57, 60, 61, 65, and 89), the conformations labeled `A` were
selected. In each Modeler run 5 structural models of Fc.gamma.RIIIb
were generated. The following parameter values or options were
used: `library_schedule` of 1, `max_var_iterations` of 300,
`md_level` of `refine1`, `repeat optimization` of 3, and
`max_molpdf` of 1e6. The best model from these runs had the
sequence alignment given in FIG. 18, and used the structural
template of Fc.gamma.RIIa, where residues 10, 21, 33, 57, 60, 61,
65, and 89 had side-chains in the `A` conformation. The criteria
for judging the `best` model included the lowest value of the
Modeler objective function (or -1.0.times.ln(Molecular probability
density function=Mpdf)), `well-behaved` PROSAII (M. Sippl,
Proteins, vol. 17, 355-362(1993)) residue energy plot for the model
(for example, negative residue energy scores throughout the
sequence), and `well-behaved` PROFILES-3D (J. U. Bowie et al.,
Science, vol. 253, 164-170(1991)) local 3D-1D compatibility score
plot (for example, positive plot scores throughout the
sequence).
[0202] Next, Modeler was used to generate 20 different structural
models of Fc.gamma.RIIIb using the sequence alignment and template
selected above, and using the parameter values and options listed
above. The model with the lowest -ln(Mpdf) value (i.e. 933.3) was
then selected as the final structural model of the Fc.gamma.RIIIb
monomer, and the corresponding heavy (non-hydrogen) atom Cartesian
coordinates are represented in Table 5. This structure was
validated with the programs PROSAII, PROFILES-3D, and PROCHECK (R.
M. Laskowski et al., J. Appl. Cryst. vol. 26, 283-291(1993)).
[0203] The model of the 3-dimensional structure of Fc.gamma.RIIIb
monomer represented by the coordinates in Table 5 may be used as a
basis for drug design in the same manner as that described for the
crystallographic coordinates of Fc.gamma.RIIa herein.
[0204] While various embodiments of the present invention have been
described in detail, it is apparent that modifications and
adaptations of those embodiments will occur to those skilled in the
art. It is to be expressly understood, however, that such
modifications and adaptations are within the scope of the present
invention, as set forth in the following claims.
Sequence CWU 1
1
15 1 30 DNA Artificial Sequence Description of Artificial
SequencePRIMER 1 tacgaattcc tatggagacc caaatgtctc 30 2 30 DNA
Artificial Sequence Description of Artificial SequencePRIMER 2
cattctagac tattggacag tgatggtcac 30 3 171 PRT Homo sapiens 3 Ala
Pro Pro Lys Ala Val Leu Lys Leu Glu Pro Pro Trp Ile Asn Val 1 5 10
15 Leu Gln Glu Asp Ser Val Thr Leu Thr Cys Gln Gly Ala Arg Ser Pro
20 25 30 Glu Ser Asp Ser Ile Gln Trp Phe His Asn Gly Asn Leu Ile
Pro Thr 35 40 45 His Thr Gln Pro Ser Tyr Arg Phe Lys Ala Asn Asn
Asn Asp Ser Gly 50 55 60 Glu Tyr Thr Cys Gln Thr Gly Gln Thr Ser
Leu Ser Asp Pro Val His 65 70 75 80 Leu Thr Val Leu Phe Glu Trp Leu
Val Leu Gln Thr Pro His Leu Glu 85 90 95 Phe Gln Glu Gly Glu Thr
Ile Met Leu Arg Cys His Ser Trp Lys Asp 100 105 110 Lys Pro Leu Val
Lys Val Thr Phe Phe Gln Asn Gly Lys Ser Gln Lys 115 120 125 Phe Ser
His Leu Asp Pro Thr Phe Ser Ile Pro Gln Ala Asn His Ser 130 135 140
His Ser Gly Asp Tyr His Cys Thr Gly Asn Ile Gly Tyr Thr Leu Phe 145
150 155 160 Ser Ser Lys Pro Val Thr Ile Thr Val Gln Val 165 170 4 8
PRT Homo sapiens 4 Ala Pro Pro Lys Ala Val Leu Lys 1 5 5 170 PRT
Homo sapiens 5 Ala Pro Pro Lys Ala Val Leu Lys Leu Glu Pro Gln Trp
Ile Asn Val 1 5 10 15 Leu Gln Glu Asp Ser Val Thr Leu Thr Cys Arg
Gly Thr His Ser Pro 20 25 30 Glu Ser Asp Ser Ile Gln Trp Phe His
Asn Gly Asn Leu Ile Pro Thr 35 40 45 His Thr Gln Pro Ser Tyr Arg
Phe Lys Ala Asn Asn Asn Asp Ser Gly 50 55 60 Glu Tyr Thr Cys Gln
Thr Gly Gln Thr Ser Leu Ser Asp Pro Val His 65 70 75 80 Leu Thr Val
Leu Ser Glu Trp Leu Val Leu Gln Thr Pro His Leu Glu 85 90 95 Phe
Gln Glu Gly Glu Thr Ile Val Leu Arg Cys His Ser Trp Lys Asp 100 105
110 Lys Pro Leu Val Lys Val Thr Phe Phe Gln Asn Gly Lys Ser Lys Lys
115 120 125 Phe Ser Arg Ser Ile Pro Asn Phe Ser Ile Pro Gln Ala Asn
His Ser 130 135 140 His Ser Gly Asp Tyr His Cys Thr Gly Asn Ile Gly
Tyr Thr Leu Tyr 145 150 155 160 Ser Ser Lys Pro Val Thr Ile Thr Val
Gln 165 170 6 170 PRT Homo sapiens 6 Ala Pro Pro Lys Ala Val Leu
Lys Leu Glu Pro Gln Trp Ile Asn Val 1 5 10 15 Leu Gln Glu Asp Ser
Val Thr Leu Thr Cys Arg Gly Thr His Ser Pro 20 25 30 Glu Ser Asp
Ser Ile Gln Trp Phe His Asn Gly Asn Leu Ile Pro Thr 35 40 45 His
Thr Gln Pro Ser Tyr Arg Phe Lys Ala Asn Asn Asn Asp Ser Gly 50 55
60 Glu Tyr Thr Cys Gln Thr Gly Gln Thr Ser Leu Ser Asp Pro Val His
65 70 75 80 Leu Thr Val Leu Ser Glu Trp Leu Val Leu Gln Thr Pro His
Leu Glu 85 90 95 Phe Gln Glu Gly Glu Thr Ile Val Leu Arg Cys His
Ser Trp Lys Asp 100 105 110 Lys Pro Leu Val Lys Val Thr Phe Phe Gln
Asn Gly Lys Ser Lys Lys 115 120 125 Phe Ser Arg Ser Asp Pro Asn Phe
Ser Ile Pro Gln Ala Asn His Ser 130 135 140 His Ser Gly Asp Tyr His
Cys Thr Gly Asn Ile Gly Tyr Thr Leu Tyr 145 150 155 160 Ser Ser Lys
Pro Val Thr Ile Thr Val Gln 165 170 7 261 PRT Homo sapiens 7 Thr
Thr Lys Ala Val Ile Thr Leu Gln Pro Pro Trp Val Ser Val Phe 1 5 10
15 Gln Glu Glu Thr Val Thr Leu His Cys Glu Val Leu His Leu Pro Gly
20 25 30 Ser Ser Ser Thr Gln Trp Phe Val Asn Gly Thr Ala Thr Gln
Thr Ser 35 40 45 Thr Pro Ser Tyr Arg Ile Thr Ser Ala Ser Val Asn
Asp Ser Gly Glu 50 55 60 Tyr Arg Cys Gln Arg Gly Leu Ser Gly Arg
Ser Asp Pro Ile Gln Leu 65 70 75 80 Glu Ile His Arg Gly Trp Leu Leu
Leu Gln Val Ser Ser Arg Val Phe 85 90 95 Thr Glu Gly Glu Pro Leu
Ala Leu Arg Cys His Ala Trp Lys Asp Lys 100 105 110 Leu Val Tyr Asn
Val Leu Tyr Tyr Arg Asn Gly Lys Phe Lys Phe Phe 115 120 125 His Trp
Asn Ser Asn Leu Thr Ile Leu Lys Thr Asn Ile Ser His Asn 130 135 140
Gly Thr Tyr His Cys Ser Gly Met Gly Lys His Arg Tyr Thr Ser Ala 145
150 155 160 Gly Ile Ser Val Thr Val Lys Glu Leu Phe Pro Ala Pro Val
Leu Asn 165 170 175 Ala Ser Val Thr Ser Pro Leu Leu Glu Gly Asn Leu
Val Thr Leu Ser 180 185 190 Cys Glu Thr Lys Leu Leu Lys Gln Arg Pro
Gly Leu Gln Leu Tyr Phe 195 200 205 Ser Phe Tyr Met Gly Ser Lys Thr
Leu Arg Gly Arg Asn Thr Ser Ser 210 215 220 Glu Tyr Gln Ile Leu Thr
Ala Arg Arg Glu Asp Ser Gly Leu Tyr Trp 225 230 235 240 Cys Glu Ala
Ala Thr Glu Asp Gly Asn Val Leu Lys Arg Ser Pro Glu 245 250 255 Leu
Glu Leu Gln Val 260 8 174 PRT Homo sapiens 8 Arg Thr Glu Asp Leu
Pro Lys Ala Val Val Phe Leu Glu Pro Gln Trp 1 5 10 15 Tyr Ser Val
Leu Glu Lys Asp Ser Val Thr Leu Lys Cys Gln Gly Ala 20 25 30 Tyr
Ser Pro Glu Asp Asn Ser Thr Gln Trp Phe His Asn Glu Ser Leu 35 40
45 Ile Ser Ser Gln Ala Ser Ser Tyr Phe Ile Asp Ala Ala Thr Val Asn
50 55 60 Asp Ser Gly Glu Tyr Arg Cys Gln Thr Asn Leu Ser Thr Leu
Ser Asp 65 70 75 80 Pro Val Gln Leu Glu Val His Ile Gly Trp Leu Leu
Leu Gln Ala Pro 85 90 95 Arg Trp Val Phe Lys Glu Glu Asp Pro Ile
His Leu Arg Cys His Ser 100 105 110 Trp Lys Asn Thr Ala Leu His Lys
Val Thr Tyr Leu Gln Asn Gly Lys 115 120 125 Asp Arg Lys Tyr Phe His
His Asn Ser Asp Phe His Ile Pro Lys Ala 130 135 140 Thr Leu Lys Asp
Ser Gly Ser Tyr Phe Cys Arg Gly Leu Val Gly Ser 145 150 155 160 Lys
Asn Val Ser Ser Glu Thr Val Asn Ile Thr Ile Thr Gln 165 170 9 172
PRT Homo sapiens 9 Val Pro Gln Lys Pro Lys Val Ser Leu Asn Pro Pro
Trp Asn Arg Ile 1 5 10 15 Phe Lys Gly Glu Asn Val Thr Leu Thr Cys
Asn Gly Asn Asn Phe Phe 20 25 30 Glu Val Ser Ser Thr Lys Trp Phe
His Asn Gly Ser Leu Ser Glu Glu 35 40 45 Thr Asn Ser Ser Leu Asn
Ile Val Asn Ala Lys Phe Glu Asp Ser Gly 50 55 60 Glu Tyr Lys Cys
Gln His Gln Gln Val Asn Glu Ser Glu Pro Val Tyr 65 70 75 80 Leu Glu
Val Phe Ser Asp Trp Leu Leu Leu Gln Ala Ser Ala Glu Val 85 90 95
Val Met Glu Gly Gln Pro Leu Phe Leu Arg Cys His Gly Trp Arg Asn 100
105 110 Trp Asp Val Tyr Lys Val Ile Tyr Tyr Lys Asp Gly Glu Ala Leu
Lys 115 120 125 Tyr Trp Tyr Glu Asn His Asn Ile Ser Ile Thr Asn Ala
Thr Val Glu 130 135 140 Asp Ser Gly Thr Tyr Tyr Cys Thr Gly Lys Val
Trp Gln Leu Asp Tyr 145 150 155 160 Glu Ser Glu Pro Leu Asn Ile Thr
Val Ile Lys Ala 165 170 10 170 PRT Homo sapiens 10 Ala Pro Pro Lys
Ala Val Leu Lys Leu Glu Pro Pro Trp Ile Asn Val 1 5 10 15 Leu Gln
Glu Asp Ser Val Thr Leu Thr Cys Gln Gly Ala Arg Ser Pro 20 25 30
Glu Ser Asp Ser Ile Gln Trp Phe His Asn Gly Asn Leu Ile Pro Thr 35
40 45 His Thr Gln Pro Ser Tyr Arg Phe Lys Ala Asn Asn Asn Asp Ser
Gly 50 55 60 Glu Tyr Thr Cys Gln Thr Gly Gln Thr Ser Leu Ser Asp
Pro Val His 65 70 75 80 Leu Thr Val Leu Ser Glu Trp Leu Val Leu Gln
Thr Pro His Leu Glu 85 90 95 Phe Gln Glu Gly Glu Thr Ile Met Leu
Arg Cys His Ser Trp Lys Asp 100 105 110 Lys Pro Leu Val Lys Val Thr
Phe Phe Gln Asn Gly Lys Ser Gln Lys 115 120 125 Phe Ser Arg Leu Asp
Pro Thr Phe Ser Ile Pro Gln Ala Asn His Ser 130 135 140 His Ser Gly
Asp Tyr His Cys Thr Gly Asn Ile Gly Tyr Thr Leu Phe 145 150 155 160
Ser Ser Lys Pro Val Thr Ile Thr Val Gln 165 170 11 170 PRT Homo
sapiens 11 Ala Pro Pro Lys Ala Val Leu Lys Leu Glu Pro Pro Trp Ile
Asn Val 1 5 10 15 Leu Gln Glu Asp Ser Val Thr Leu Thr Cys Trp Gly
Ala Arg Ser Pro 20 25 30 Glu Ser Asp Ser Ile Gln Trp Phe His Asn
Gly Asn Leu Ile Pro Thr 35 40 45 His Thr Gln Pro Ser Tyr Arg Phe
Lys Ala Asn Asn Asn Asp Ser Gly 50 55 60 Glu Tyr Thr Cys Gln Thr
Gly Gln Thr Ser Leu Ser Asp Pro Val His 65 70 75 80 Leu Thr Val Leu
Phe Glu Trp Leu Val Leu Gln Thr Pro His Leu Glu 85 90 95 Phe Gln
Glu Gly Glu Thr Ile Met Leu Arg Cys His Ser Trp Lys Asp 100 105 110
Lys Pro Leu Val Lys Val Thr Phe Phe Gln Asn Gly Lys Ser Gln Lys 115
120 125 Phe Ser His Leu Asp Pro Thr Phe Ser Ile Pro Gln Ala Asn His
Ser 130 135 140 His Ser Gly Asp Tyr His Cys Thr Gly Asn Ile Gly Tyr
Thr Leu Phe 145 150 155 160 Ser Ser Lys Pro Val Thr Ile Thr Val Gln
165 170 12 170 PRT Homo sapiens 12 Ala Pro Pro Lys Ala Val Leu Lys
Leu Glu Pro Pro Trp Ile Asn Val 1 5 10 15 Leu Gln Glu Asp Ser Val
Thr Leu Thr Cys Trp Gly Ala Arg Ser Pro 20 25 30 Glu Ser Asp Ser
Ile Gln Trp Phe His Asn Gly Asn Leu Ile Pro Thr 35 40 45 His Thr
Gln Pro Ser Tyr Arg Phe Lys Ala Asn Asn Asn Asp Ser Gly 50 55 60
Glu Tyr Thr Cys Gln Thr Gly Gln Thr Ser Leu Ser Asp Pro Val His 65
70 75 80 Leu Thr Val Leu Phe Glu Trp Leu Val Leu Gln Thr Pro His
Leu Glu 85 90 95 Phe Gln Glu Gly Glu Thr Ile Met Leu Arg Cys His
Ser Trp Lys Asp 100 105 110 Lys Pro Leu Val Lys Val Thr Phe Phe Gln
Asn Gly Lys Ser Gln Lys 115 120 125 Phe Ser Arg Leu Asp Pro Thr Phe
Ser Ile Pro Gln Ala Asn His Ser 130 135 140 His Ser Gly Asp Tyr His
Cys Thr Gly Asn Ile Gly Tyr Thr Leu Phe 145 150 155 160 Ser Ser Lys
Pro Val Thr Ile Thr Val Gln 165 170 13 287 PRT Homo sapiens 13 Met
Asp Pro Lys Gln Thr Thr Leu Leu Cys Leu Val Leu Cys Leu Gly 1 5 10
15 Gln Arg Ile Gln Ala Gln Glu Gly Asp Phe Pro Met Pro Phe Ile Ser
20 25 30 Ala Lys Ser Ser Pro Val Ile Pro Leu Asp Gly Ser Val Lys
Ile Gln 35 40 45 Cys Gln Ala Ile Arg Glu Ala Tyr Leu Thr Gln Leu
Met Ile Ile Lys 50 55 60 Asn Ser Thr Tyr Arg Glu Ile Gly Arg Arg
Leu Lys Phe Trp Asn Glu 65 70 75 80 Thr Asp Pro Glu Phe Val Ile Asp
His Met Asp Ala Asn Lys Ala Gly 85 90 95 Arg Tyr Gln Cys Gln Tyr
Arg Ile Gly His Tyr Arg Phe Arg Tyr Ser 100 105 110 Asp Thr Leu Glu
Leu Val Val Thr Gly Leu Tyr Gly Lys Pro Phe Leu 115 120 125 Ser Ala
Asp Arg Gly Leu Val Leu Met Pro Gly Glu Asn Ile Ser Leu 130 135 140
Thr Cys Ser Ser Ala His Ile Pro Phe Asp Arg Phe Ser Leu Ala Lys 145
150 155 160 Glu Gly Glu Leu Ser Leu Pro Gln His Gln Ser Gly Glu His
Pro Ala 165 170 175 Asn Phe Ser Leu Gly Pro Val Asp Leu Asn Val Ser
Gly Ile Tyr Arg 180 185 190 Cys Tyr Gly Trp Tyr Asn Arg Ser Pro Tyr
Leu Trp Ser Phe Pro Ser 195 200 205 Asn Ala Leu Glu Leu Val Val Thr
Asp Ser Ile His Gln Asp Tyr Thr 210 215 220 Thr Gln Asn Leu Ile Arg
Met Ala Val Ala Gly Leu Val Leu Val Ala 225 230 235 240 Leu Leu Ala
Ile Leu Val Glu Asn Trp His Ser His Thr Ala Leu Asn 245 250 255 Lys
Glu Ala Ser Ala Asp Val Ala Glu Pro Ser Trp Ser Gln Gln Met 260 265
270 Cys Gln Pro Gly Leu Thr Phe Ala Arg Thr Pro Ser Val Cys Lys 275
280 285 14 171 PRT Homo sapiens 14 Ala Ala Pro Pro Lys Ala Val Leu
Lys Leu Glu Pro Pro Trp Ile Asn 1 5 10 15 Val Leu Gln Glu Asp Ser
Val Thr Leu Thr Cys Gln Gly Ala Arg Ser 20 25 30 Pro Glu Ser Asp
Ser Ile Gln Trp Phe His Asn Gly Asn Leu Ile Pro 35 40 45 Thr His
Thr Gln Pro Ser Tyr Arg Phe Lys Ala Asn Asn Asn Asp Ser 50 55 60
Gly Glu Tyr Thr Cys Gln Thr Gly Gln Thr Ser Leu Ser Asp Pro Val 65
70 75 80 His Leu Thr Val Leu Ser Glu Trp Leu Val Leu Gln Thr Pro
His Leu 85 90 95 Glu Phe Gln Glu Gly Glu Thr Ile Met Leu Arg Cys
His Ser Trp Lys 100 105 110 Asp Lys Pro Leu Val Lys Val Thr Phe Phe
Gln Asn Gly Lys Ser Gln 115 120 125 Lys Phe Ser His Leu Asp Pro Thr
Phe Ser Ile Pro Gln Ala Asn His 130 135 140 Ser His Ser Gly Asp Tyr
His Cys Thr Gly Asn Ile Gly Tyr Thr Leu 145 150 155 160 Phe Ser Ser
Lys Pro Val Thr Ile Thr Val Gln 165 170 15 171 PRT Homo sapiens 15
Ala Ala Pro Pro Lys Ala Val Leu Lys Leu Glu Pro Pro Trp Ile Asn 1 5
10 15 Val Leu Gln Glu Asp Ser Val Thr Leu Thr Cys Gln Gly Ala Arg
Ser 20 25 30 Pro Glu Ser Asp Ser Ile Gln Trp Phe His Asn Gly Asn
Leu Ile Pro 35 40 45 Thr His Thr Gln Pro Ser Tyr Arg Phe Lys Ala
Asn Asn Asn Asp Ser 50 55 60 Gly Glu Tyr Thr Cys Gln Thr Gly Gln
Thr Ser Leu Ser Asp Pro Val 65 70 75 80 His Leu Thr Val Leu Phe Glu
Trp Leu Val Leu Gln Thr Pro His Leu 85 90 95 Glu Phe Gln Glu Gly
Glu Thr Ile Met Leu Arg Cys His Ser Trp Lys 100 105 110 Asp Lys Pro
Leu Val Lys Val Thr Phe Phe Gln Asn Gly Lys Ser Gln 115 120 125 Lys
Phe Ser His Leu Asp Pro Thr Phe Ser Ile Pro Gln Ala Asn His 130 135
140 Ser His Ser Gly Asp Tyr His Cys Thr Gly Asn Ile Gly Tyr Thr Leu
145 150 155 160 Phe Ser Ser Lys Pro Val Thr Ile Thr Val Gln 165
170
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