U.S. patent application number 10/651165 was filed with the patent office on 2004-03-11 for immunodominant human t-cell epitopes of hepatitis c virus. This patent application is currently assigned to Innogenetics. Invention is credited to Deleys, Robert, Leroux-Roels, Geert, Maertens, Geert.
Application Number | 20040047877 10/651165 |
Document ID | / |
Family ID | 8214764 |
Filed Date | 2004-03-11 |
United States Patent Application | 20040047877 |
Kind Code | A1 |
Leroux-Roels, Geert ; et al. | March 11, 2004 |
The present invention relates to a polypeptide of about 8 to about 100 amino acids comprising or consisting of at least 8 contiguous amino acids selected from the core, and/or the E1, and/or E2, and/or the NS3 regions of the HCV polyprotein, with said contiguous amino acids containing a T-ell stimulating epitope.
Inventors: | Leroux-Roels, Geert; (Ghent, BE) ; Deleys, Robert; (Grimbergen, BE) ; Maertens, Geert; (Brugge, BE) |
Correspondence Address: |
NIXON & VANDERHYE, PC 1100 N GLEBE ROAD 8TH FLOOR ARLINGTON VA 22201-4714 US |
Assignee: | Innogenetics |
Family ID: | 8214764 |
Appl. No.: | 10/651165 |
Filed: | August 29, 2003 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
10651165 | Aug 29, 2003 | |||
08974690 | Nov 19, 1997 | |||
6613333 | ||||
08974690 | Nov 19, 1997 | |||
08635886 | Apr 25, 1996 | |||
6555114 | ||||
08635886 | Apr 25, 1996 | |||
PCT/EP94/03555 | Oct 28, 1994 | |||
Current U.S. Class: | 424/185.1 ; 424/189.1; 530/350 |
Current CPC Class: | A61P 31/14 20180101; C12N 2770/36022 20130101; A61P 31/12 20180101; C12N 2770/24222 20130101; A61K 39/00 20130101; Y10S 530/806 20130101; Y10S 530/826 20130101; C07K 14/005 20130101; A61P 37/04 20180101; C07K 2319/00 20130101 |
Class at Publication: | 424/185.1 ; 424/189.1; 530/350 |
International Class: | A61K 039/12; C07K 014/18 |
Date | Code | Application Number |
---|---|---|
Nov 4, 1993 | EP | 93402718.6 |
Sequence CWU 1
1
286 1 15 PRT hepatitis C virus 1 Pro Lys Pro Gln Arg Lys Thr Lys
Arg Asn Thr Asn Arg Arg Pro 1 5 10 15 2 20 PRT hepatitis C virus 2
Arg Asn Thr Asn Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly 1 5
10 15 Gln Ile Val Gly 20 3 20 PRT hepatitis C virus 3 Pro Gly Gly
Gly Gln Ile Val Gly Gly Val Tyr Leu Leu Pro Arg Arg 1 5 10 15 Gly
Pro Arg Leu 20 4 20 PRT hepatitis C virus 4 Thr Arg Lys Thr Ser Glu
Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 1 5 10 15 Ile Pro Lys Val
20 5 20 PRT hepatitis C virus 5 Arg Arg Gln Pro Ile Pro Lys Val Arg
Arg Pro Glu Gly Arg Thr Trp 1 5 10 15 Ala Gln Pro Gly 20 6 20 PRT
hepatitis C virus 6 Gly Arg Thr Trp Ala Gln Pro Gly Tyr Pro Trp Pro
Leu Tyr Gly Asn 1 5 10 15 Glu Gly Cys Gly 20 7 20 PRT hepatitis C
virus 7 Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp Leu Leu Ser
Pro 1 5 10 15 Arg Gly Ser Arg 20 8 20 PRT hepatitis C virus 8 Leu
Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 1 5 10
15 Arg Arg Arg Ser 20 9 20 PRT hepatitis C virus 9 Pro Thr Asp Pro
Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp 1 5 10 15 Thr Leu
Thr Cys 20 10 20 PRT hepatitis C virus 10 Lys Val Ile Asp Thr Leu
Thr Cys Gly Phe Ala Asp Leu Met Gly Tyr 1 5 10 15 Ile Pro Leu Val
20 11 20 PRT hepatitis C virus 11 Leu Met Gly Tyr Ile Pro Leu Val
Gly Ala Pro Leu Gly Gly Ala Ala 1 5 10 15 Arg Ala Leu Ala 20 12 20
PRT hepatitis C virus 12 Gly Gly Ala Ala Arg Ala Leu Ala His Gly
Val Arg Val Leu Glu Asp 1 5 10 15 Gly Val Asn Tyr 20 13 20 PRT
hepatitis C virus 13 Val Leu Glu Asp Gly Val Asn Tyr Ala Thr Gly
Asn Leu Pro Gly Cys 1 5 10 15 Ser Phe Ser Ile 20 14 20 PRT
hepatitis C virus 14 Leu Pro Gly Cys Ser Phe Ser Ile Phe Leu Leu
Ala Leu Leu Ser Cys 1 5 10 15 Leu Thr Val Pro 20 15 20 PRT
hepatitis C virus 15 Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala
Tyr Gln Val Arg Asn 1 5 10 15 Ser Thr Gly Leu 20 16 20 PRT
hepatitis C virus 16 Gln Val Arg Asn Ser Thr Gly Leu Tyr His Val
Thr Asn Asp Cys Pro 1 5 10 15 Asn Ser Ser Ile 20 17 20 PRT
hepatitis C virus 17 Asn Asp Cys Pro Asn Ser Ser Ile Val Tyr Glu
Ala His Asp Ala Ile 1 5 10 15 Leu His Thr Pro 20 18 20 PRT
hepatitis C virus 18 His Asp Ala Ile Leu His Thr Pro Gly Cys Val
Pro Cys Val Arg Glu 1 5 10 15 Gly Asn Val Ser 20 19 20 PRT
hepatitis C virus 19 Cys Val Arg Glu Gly Asn Val Ser Arg Cys Trp
Val Ala Met Thr Pro 1 5 10 15 Thr Val Ala Thr 20 20 21 PRT
hepatitis C virus 20 Ala Met Thr Pro Thr Val Ala Thr Arg Asp Gly
Lys Leu Pro Pro Ala 1 5 10 15 Thr Gln Leu Arg Arg 20 21 20 PRT
hepatitis C virus 21 Leu Pro Ala Thr Gln Leu Arg Arg His Ile Asp
Leu Leu Val Gly Ser 1 5 10 15 Ala Thr Leu Cys 20 22 20 PRT
hepatitis C virus 22 Leu Val Gly Ser Ala Thr Leu Cys Ser Ala Leu
Tyr Val Gly Asp Leu 1 5 10 15 Cys Gly Ser Val 20 23 20 PRT
hepatitis C virus 23 Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp
Thr Thr Gln Gly Cys 1 5 10 15 Asn Cys Ser Ile 20 24 20 PRT
hepatitis C virus 24 Thr Gln Gly Cys Asn Cys Ser Ile Tyr Pro Gly
His Ile Thr Gly His 1 5 10 15 Arg Met Ala Trp 20 25 20 PRT
hepatitis C virus 25 Ile Thr Gly His Arg Met Ala Trp Asp Met Met
Met Asn Trp Ser Pro 1 5 10 15 Thr Ala Ala Leu 20 26 20 PRT
hepatitis C virus 26 Asn Trp Ser Pro Thr Ala Ala Leu Val Met Ala
Gln Leu Leu Arg Ile 1 5 10 15 Pro Gln Ala Ile 20 27 20 PRT
hepatitis C virus 27 Leu Leu Arg Ile Pro Gln Ala Ile Leu Asp Met
Ile Ala Gly Ala His 1 5 10 15 Trp Gly Val Leu 20 28 20 PRT
hepatitis C virus 28 Ala Gly Ala His Trp Gly Val Leu Ala Gly Ile
Ala Tyr Phe Ser Met 1 5 10 15 Val Gly Asn Trp 20 29 20 PRT
hepatitis C virus 29 Val Val Leu Leu Leu Phe Ala Gly Val Asp Ala
Glu Thr Ile Val Ser 1 5 10 15 Gly Gly Gln Ala 20 30 21 PRT
hepatitis C virus 30 Leu Asn Cys Asn Glu Ser Leu Asn Thr Gly Trp
Trp Leu Ala Gly Leu 1 5 10 15 Ile Tyr Gln His Lys 20 31 20 PRT
hepatitis C virus 31 Ala Gly Leu Ile Tyr Gln His Lys Phe Asn Ser
Ser Gly Cys Pro Glu 1 5 10 15 Arg Leu Ala Ser 20 32 20 PRT
hepatitis C virus 32 Gly Cys Pro Glu Arg Leu Ala Ser Cys Arg Pro
Leu Thr Asp Phe Asp 1 5 10 15 Gln Gly Trp Gly 20 33 20 PRT
hepatitis C virus 33 Thr Asp Phe Asp Gln Gly Trp Gly Pro Ile Ser
Tyr Ala Asn Gly Ser 1 5 10 15 Gly Pro Asp Gln 20 34 20 PRT
hepatitis C virus 34 Ala Asn Gly Ser Gly Pro Asp Gln Arg Pro Tyr
Cys Trp His Tyr Pro 1 5 10 15 Pro Lys Pro Cys 20 35 20 PRT
hepatitis C virus 35 Trp His Tyr Pro Pro Lys Pro Cys Gly Ile Val
Pro Ala Lys Ser Val 1 5 10 15 Cys Gly Pro Val 20 36 20 PRT
hepatitis C virus 36 Ala Lys Ser Val Cys Gly Pro Val Tyr Cys Phe
Thr Pro Ser Pro Val 1 5 10 15 Val Val Gly Thr 20 37 20 PRT
hepatitis C virus 37 Pro Ser Pro Val Val Val Gly Thr Thr Asp Arg
Ser Gly Ala Pro Thr 1 5 10 15 Tyr Ser Trp Gly 20 38 20 PRT
hepatitis C virus 38 Gly Ala Pro Thr Tyr Ser Trp Gly Glu Asn Asp
Thr Asp Val Phe Val 1 5 10 15 Leu Asn Asn Thr 20 39 20 PRT
hepatitis C virus 39 Gly Asn Trp Phe Gly Cys Thr Trp Met Asn Ser
Thr Gly Phe Thr Lys 1 5 10 15 Val Cys Gly Ala 20 40 20 PRT
hepatitis C virus 40 Gly Phe Thr Lys Val Cys Gly Ala Pro Pro Val
Cys Ile Gly Gly Ala 1 5 10 15 Gly Asn Asn Thr 20 41 20 PRT
hepatitis C virus 41 Ile Gly Gly Ala Gly Asn Asn Thr Leu His Cys
Pro Thr Asp Cys Phe 1 5 10 15 Arg Lys His Pro 20 42 20 PRT
hepatitis C virus 42 Thr Asp Cys Phe Arg Lys His Pro Asp Ala Thr
Tyr Ser Arg Cys Gly 1 5 10 15 Ser Gly Pro Trp 20 43 20 PRT
hepatitis C virus 43 Ser Arg Cys Gly Ser Gly Pro Trp Ile Thr Pro
Arg Cys Leu Val Asp 1 5 10 15 Tyr Pro Tyr Arg 20 44 20 PRT
hepatitis C virus 44 Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His
Tyr Pro Cys Thr Ile 1 5 10 15 Asn Tyr Thr Ile 20 45 20 PRT
hepatitis C virus 45 Pro Cys Thr Ile Asn Tyr Thr Ile Phe Lys Ile
Arg Met Tyr Val Gly 1 5 10 15 Gly Val Glu His 20 46 20 PRT
hepatitis C virus 46 Ser Gly Leu Val Ser Leu Phe Thr Pro Gly Ala
Lys Gln Asn Ile Gln 1 5 10 15 Leu Ile Asn Thr 20 47 20 PRT
hepatitis C virus 47 Gln Asn Ile Gln Leu Ile Asn Thr Asn Gly Ser
Trp His Ile Asn Ser 1 5 10 15 Thr Ala Leu Asn 20 48 68 PRT
hepatitis C virus MISC_FEATURE (1) Xaa is Pro or Gln 48 Xaa Xaa Asp
Pro Arg Xaa Xaa Ser Arg Asn Xaa Gly Xaa Val Ile Asp 1 5 10 15 Thr
Xaa Thr Cys Gly Xaa Ala Asp Leu Xaa Xaa Tyr Ile Pro Xaa Xaa 20 25
30 Gly Xaa Pro Xaa Gly Gly Xaa Xaa Xaa Xaa Leu Xaa His Gly Val Arg
35 40 45 Xaa Xaa Xaa Asp Gly Xaa Asn Xaa Xaa Thr Gly Asn Xaa Pro
Gly Cys 50 55 60 Ser Phe Ser Ile 65 49 32 PRT hepatitis C virus
MISC_FEATURE (1)..(1) Xaa is Ser, Ala, Gln, Leu, Asn, Tyr, Arg or
His 49 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Gln Xaa Xaa
Xaa 1 5 10 15 Leu Xaa Asn Xaa Asn Gly Ser Trp His Xaa Asn Xaa Thr
Ala Leu Asn 20 25 30 50 44 PRT hepatitis C virus MISC_FEATURE
(2)..(2) Xaa is Met or Ile 50 Leu Xaa Xaa Tyr Ile Pro Xaa Xaa Gly
Xaa Pro Xaa Gly Gly Xaa Xaa 1 5 10 15 Xaa Xaa Leu Xaa His Gly Val
Arg Xaa Xaa Xaa Asp Gly Xaa Asn Xaa 20 25 30 Xaa Thr Gly Asn Xaa
Pro Gly Cys Ser Phe Ser Ile 35 40 51 20 PRT hepatitis C virus
MISC_FEATURE (1)..(1) Xaa is Val, Ala or Leu 51 Xaa Xaa Xaa Asp Gly
Xaa Asn Xaa Xaa Thr Gly Asn Xaa Pro Gly Cys 1 5 10 15 Ser Phe Ser
Ile 20 52 20 PRT hepatitis C virus MISC_FEATURE (3)..(3) Xaa is Ala
or Val 52 Gly Gly Xaa Xaa Xaa Xaa Leu Xaa His Gly Val Arg Xaa Xaa
Xaa Asp 1 5 10 15 Gly Xaa Asn Xaa 20 53 20 PRT hepatitis C virus
MISC_FEATURE (2)..(2) Xaa is Met or Ile 53 Leu Xaa Xaa Tyr Ile Pro
Xaa Xaa Gly Xaa Pro Xaa Gly Gly Xaa Xaa 1 5 10 15 Xaa Xaa Leu Xaa
20 54 20 PRT hepatitis C virus MISC_FEATURE (1)..(1) Xaa is Pro or
Gln 54 Xaa Xaa Asp Pro Arg Xaa Xaa Ser Arg Asn Xaa Gly Xaa Val Ile
Asp 1 5 10 15 Thr Xaa Thr Cys 20 55 20 PRT hepatitis C virus
MISC_FEATURE (1)..(1) Xaa is Ser, Ala, Gln, Leu, Asn, Tyr, Arg or
His 55 Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Xaa Gly Xaa Xaa Gln Xaa Xaa
Xaa 1 5 10 15 Leu Xaa Asn Xaa 20 56 20 PRT hepatitis C virus
MISC_FEATURE (2)..(2) Xaa is Asn, Lys, Asp or Arg 56 Gln Xaa Xaa
Xaa Leu Xaa Asn Xaa Asn Gly Ser Trp His Xaa Asn Xaa 1 5 10 15 Thr
Ala Leu Asn 20 57 278 PRT hepatitis C virus 57 Gly Val Ala Lys Ala
Val Asp Phe Val Pro Val Glu Ser Met Glu Thr 1 5 10 15 Thr Met Arg
Ser Pro Val Phe Thr Asp Asn Ser Ser Pro Pro Ala Val 20 25 30 Pro
Gln Thr Phe Gln Val Ala His Leu His Ala Pro Thr Gly Ser Gly 35 40
45 Lys Ser Thr Lys Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr Lys Val
50 55 60 Leu Val Leu Asn Pro Ser Val Ala Ala Thr Leu Gly Phe Gly
Ala Tyr 65 70 75 80 Met Ser Lys Ala His Gly Val Asp Pro Asn Ile Arg
Thr Gly Val Arg 85 90 95 Thr Ile Thr Thr Gly Ala Pro Ile Thr Tyr
Ser Thr Tyr Gly Lys Phe 100 105 110 Leu Ala Asp Gly Gly Cys Ser Gly
Gly Ala Tyr Asp Ile Ile Ile Cys 115 120 125 Asp Glu Cys His Ser Ile
Asp Ser Thr Ser Ile Leu Gly Ile Gly Thr 130 135 140 Val Leu Asp Gln
Ala Glu Thr Ala Gly Ala Arg Leu Val Val Leu Ala 145 150 155 160 Thr
Ala Thr Pro Pro Gly Ser Val Thr Val Pro His Pro Asn Ile Glu 165 170
175 Glu Val Ala Leu Ser Ser Thr Gly Glu Ile Pro Phe Tyr Gly Lys Ala
180 185 190 Ile Pro Ile Glu Val Ile Lys Gly Gly Arg His Leu Ile Phe
Cys His 195 200 205 Ser Lys Lys Lys Cys Asp Glu Leu Ala Ala Lys Leu
Ser Gly Phe Gly 210 215 220 Ile Asn Ala Val Ala Tyr Tyr Arg Gly Leu
Asp Val Ser Val Ile Pro 225 230 235 240 Thr Ser Gly Asp Val Val Val
Val Ala Thr Asp Ala Leu Met Thr Gly 245 250 255 Phe Thr Gly Asp Phe
Asp Ser Val Ile Asp Cys Asn Thr Cys Val Thr 260 265 270 Gln Thr Val
Asp Phe Ser 275 58 104 PRT hepatitis C virus MISC_FEATURE (2)..(2)
Xaa is Arg or Lys 58 Gly Xaa Xaa Trp Xaa Xaa Pro Gly Xaa Pro Trp
Pro Leu Tyr Xaa Asn 1 5 10 15 Xaa Gly Xaa Gly Xaa Ala Gly Trp Leu
Leu Ser Pro Arg Gly Ser Arg 20 25 30 Pro Xaa Trp Gly Xaa Xaa Asp
Pro Arg Xaa Xaa Ser Arg Asn Xaa Gly 35 40 45 Xaa Val Ile Asp Thr
Xaa Thr Cys Gly Xaa Ala Asp Leu Xaa Xaa Tyr 50 55 60 Ile Pro Xaa
Xaa Gly Xaa Pro Xaa Gly Gly Xaa Xaa Xaa Xaa Leu Xaa 65 70 75 80 His
Gly Val Arg Xaa Xaa Xaa Asp Gly Xaa Asn Xaa Xaa Thr Gly Asn 85 90
95 Xaa Pro Gly Cys Ser Phe Ser Ile 100 59 76 PRT hepatitis C virus
MISC_FEATURE (2)..(2) Xaa is Arg or Lys 59 Gly Xaa Xaa Trp Xaa Xaa
Pro Gly Xaa Pro Trp Pro Leu Tyr Xaa Asn 1 5 10 15 Xaa Gly Xaa Gly
Xaa Ala Gly Trp Leu Leu Ser Pro Arg Gly Ser Arg 20 25 30 Pro Xaa
Trp Gly Xaa Xaa Asp Pro Arg Xaa Xaa Ser Arg Asn Xaa Gly 35 40 45
Xaa Val Ile Asp Thr Xaa Thr Cys Gly Xaa Ala Asp Leu Xaa Xaa Tyr 50
55 60 Ile Pro Xaa Xaa Gly Xaa Pro Xaa Gly Gly Xaa Xaa 65 70 75 60
15 PRT hepatitis C virus MISC_FEATURE (1)..(1) Xaa is Val or Ile 60
Xaa Asn Xaa Xaa Thr Gly Asn Xaa Pro Gly Cys Ser Phe Ser Ile 1 5 10
15 61 16 PRT hepatitis C virus MISC_FEATURE (2)..(2) Xaa is Phe or
Leu 61 Gly Xaa Ala Asp Leu Xaa Xaa Tyr Ile Pro Xaa Xaa Gly Xaa Pro
Xaa 1 5 10 15 62 15 PRT hepatitis C virus MISC_FEATURE (2)..(2) Xaa
is Met or Ile 62 Leu Xaa Xaa Tyr Ile Pro Xaa Xaa Gly Xaa Pro Xaa
Gly Gly Xaa 1 5 10 15 63 14 PRT hepatitis C virus MISC_FEATURE
(1)..(1) Xaa is Met or Ile 63 Xaa Xaa Tyr Ile Pro Xaa Xaa Gly Xaa
Pro Xaa Gly Gly Xaa 1 5 10 64 9 PRT hepatitis C virus MISC_FEATURE
(4)..(4) Xaa is Leu, Val or Ile 64 Tyr Ile Pro Xaa Xaa Gly Xaa Pro
Xaa 1 5 65 8 PRT hepatitis C virus MISC_FEATURE (3)..(3) Xaa is
Leu, Val or Ile 65 Ile Pro Xaa Xaa Gly Xaa Pro Xaa 1 5 66 9 PRT
hepatitis C virus MISC_FEATURE (1)..(1) Xaa is Leu, Val or Ile 66
Xaa Xaa Gly Xaa Pro Xaa Gly Gly Xaa 1 5 67 44 PRT hepatitis C virus
67 Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu Gly Gly Ala Ala
1 5 10 15 Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp Gly Val
Asn Tyr 20 25 30 Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 35
40 68 8 PRT hepatitis C virus MISC_FEATURE (1)..(1) Xaa is Val or
Leu 68 Xaa Gly Xaa Pro Xaa Gly Gly Xaa 1 5 69 8 PRT hepatitis C
virus 69 Leu Met Gly Tyr Ile Pro Leu Val 1 5 70 7 PRT hepatitis C
virus 70 Met Gly Tyr Ile Pro Leu Val 1 5 71 9 PRT hepatitis C virus
71 Tyr Ile Pro Leu Val Gly Ala Pro Leu 1 5 72 8 PRT hepatitis C
virus 72 Ile Pro Leu Val Gly Ala Pro Leu 1 5 73 20 PRT hepatitis C
virus 73 Val Leu Glu Asp Ile Val Asn Tyr Ala Thr Gly Asn Leu Pro
Gly Cys 1 5 10 15 Ser Phe Ser Ile 20 74 9 PRT hepatitis C virus
MISC_FEATURE (2)..(2) Xaa is Val or Ile 74 Gly Xaa Asn Xaa Xaa Thr
Gly Asn Xaa 1 5 75 8 PRT hepatitis C virus MISC_FEATURE (1)..(1)
Xaa is Val or Ile 75 Xaa Asn Xaa Xaa Thr Gly Asn Xaa 1 5 76 9 PRT
hepatitis C virus MISC_FEATURE (2)..(2) Xaa is Leu or Ile 76 Asn
Xaa Pro Gly Cys Ser Phe Ser Ile 1 5 77 8 PRT hepatitis C virus
MISC_FEATURE (1)..(1) Xaa is Leu or Ile 77 Xaa Pro Gly Cys Ser Phe
Ser Ile 1 5 78 9 PRT hepatitis C virus 78 Gly Val Asn Tyr Ala Thr
Gly Asn Leu 1 5 79 9 PRT hepatitis C virus 79 Gly Val Asn Tyr Ala
Thr Gly Asn Leu 1 5 80 9 PRT hepatitis C virus 80 Asn Leu Pro Gly
Cys Ser Phe Ser Ile 1 5 81 8 PRT hepatitis C virus 81 Leu Pro Gly
Cys Ser Phe Ser Ile 1 5 82 9 PRT hepatitis C virus MISC_FEATURE
(1)..(1) Xaa is Ala, Thr or Glu 82 Xaa Leu Xaa His Gly Val Arg Xaa
Xaa 1 5 83 8 PRT hepatitis C virus MISC_FEATURE (2)..(2) Xaa is Ala
or Glu 83 Leu Xaa His Gly Val Arg Xaa Xaa 1 5 84 9 PRT hepatitis C
virus MISC_FEATURE (4)..(4) Xaa is Val, Ala or Leu 84 Gly Val Arg
Xaa Xaa Xaa Asp Gly Xaa 1
5 85 8 PRT hepatitis C virus MISC_FEATURE (3)..(3) Xaa is Val, Ala
or Leu 85 Val Arg Xaa Xaa Xaa Asp Gly Xaa 1 5 86 9 PRT hepatitis C
virus MISC_FEATURE (2)..(2) Xaa is Val, Ala or Leu 86 Arg Xaa Xaa
Xaa Asp Gly Xaa Asn Xaa 1 5 87 8 PRT hepatitis C virus MISC_FEATURE
(1)..(1) Xaa is Val, Ala or Leu 87 Xaa Xaa Xaa Asp Gly Xaa Asn Xaa
1 5 88 9 PRT hepatitis C virus 88 Ala Leu Ala His Gly Val Arg Val
Leu 1 5 89 8 PRT hepatitis C virus 89 Leu Ala His Gly Val Arg Val
Leu 1 5 90 8 PRT hepatitis C virus 90 Val Arg Val Leu Glu Asp Gly
Val 1 5 91 7 PRT hepatitis C virus 91 Arg Val Leu Glu Asp Gly Val 1
5 92 8 PRT hepatitis C virus 92 Val Leu Glu Asp Gly Val Asn Tyr 1 5
93 7 PRT hepatitis C virus 93 Leu Glu Asp Gly Val Asn Tyr 1 5 94 9
PRT hepatitis C virus 94 Leu Val Gly Ala Pro Leu Gly Gly Ala 1 5 95
8 PRT hepatitis C virus 95 Val Gly Ala Pro Leu Gly Gly Ala 1 5 96 9
PRT hepatitis C virus MISC_FEATURE (2)..(2) Xaa is Leu, Val or Phe
96 Asn Xaa Gly Xaa Val Ile Asp Thr Xaa 1 5 97 8 PRT hepatitis C
virus MISC_FEATURE (1)..(1) Xaa is Leu, Val or Phe 97 Xaa Gly Xaa
Val Ile Asp Thr Xaa 1 5 98 9 PRT hepatitis C virus 98 Asn Leu Gly
Lys Val Ile Asp Thr Leu 1 5 99 20 PRT hepatitis C virus
MISC_FEATURE (2)..(2) Xaa is Arg or Lys 99 Gly Xaa Xaa Trp Xaa Xaa
Pro Gly Xaa Pro Trp Pro Leu Tyr Xaa Asn 1 5 10 15 Xaa Gly Xaa Gly
20 100 9 PRT hepatitis C virus MISC_FEATURE (1)..(1) Xaa is Ala,
Ser or Thr 100 Xaa Trp Xaa Xaa Pro Gly Xaa Pro Trp 1 5 101 8 PRT
hepatitis C virus MISC_FEATURE (2)..(2) Xaa is Ala or Gly 101 Trp
Xaa Xaa Pro Gly Xaa Pro Trp 1 5 102 9 PRT hepatitis C virus 102 Thr
Trp Ala Gln Pro Gly Tyr Pro Trp 1 5 103 8 PRT hepatitis C virus 103
Trp Ala Gln Pro Gly Tyr Pro Trp 1 5 104 147 PRT hepatitis C virus
104 Thr Pro Thr Val Ala Thr Thr Arg Asp Gly Lys Leu Pro Ala Thr Gln
1 5 10 15 Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu
Cys Ser 20 25 30 Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Gln
Leu Phe Thr Phe 35 40 45 Ser Pro Arg Arg His Trp Thr Thr Gln Gly
Cys Asn Cys Ser Ile Tyr 50 55 60 Pro Gly His Ile Thr Gly His Arg
Met Ala Trp Asp Met Met Met Asn 65 70 75 80 Trp Ser Pro Thr Ala Ala
Leu Val Met Ala Gln Leu Leu Arg Ile Pro 85 90 95 Gln Ala Ile Leu
Asp Met Ile Ala Gly Ala His Trp Gly Val Leu Ala 100 105 110 Gly Ile
Ala Tyr Phe Ser Met Val Gly Asn Trp Ala Lys Val Leu Val 115 120 125
Val Leu Leu Leu Phe Ala Gly Val Asp Ala Glu Thr Ile Val Ser Gly 130
135 140 Gly Gln Ala 145 105 18 PRT hepatitis C virus 105 Thr Pro
Thr Val Ala Thr Thr Arg Asp Gly Lys Leu Pro Ala Thr Gln 1 5 10 15
Leu Arg 106 76 PRT hepatitis C virus 106 Leu Pro Ala Thr Gln Leu
Arg Arg His Ile Asp Leu Leu Val Gly Ser 1 5 10 15 Ala Thr Leu Cys
Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val 20 25 30 Gln Leu
Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Gly Cys 35 40 45
Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 50
55 60 Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu 65 70 75 107
69 PRT hepatitis C virus 107 Met Asn Trp Ser Pro Thr Ala Ala Leu
Val Met Ala Gln Leu Leu Arg 1 5 10 15 Ile Pro Gln Ala Ile Leu Asp
Met Ile Ala Gly Ala His Trp Gly Val 20 25 30 Leu Ala Gly Ile Ala
Tyr Phe Ser Met Val Gly Asn Trp Ala Lys Val 35 40 45 Leu Val Val
Leu Leu Leu Phe Ala Gly Val Asp Ala Glu Thr Ile Val 50 55 60 Ser
Gly Gly Gln Ala 65 108 70 PRT hepatitis C virus MISC_FEATURE
(2)..(2) Xaa is Gly or Arg 108 Ile Xaa Xaa Xaa Xaa Asn Xaa Xaa Xaa
Xaa Leu Xaa Cys Pro Thr Asp 1 5 10 15 Cys Phe Arg Lys Xaa Pro Xaa
Xaa Thr Tyr Xaa Xaa Cys Gly Xaa Gly 20 25 30 Pro Xaa Xaa Thr Pro
Arg Cys Xaa Xaa Asp Tyr Pro Tyr Arg Leu Trp 35 40 45 His Tyr Pro
Cys Thr Xaa Asn Xaa Xaa Xaa Phe Lys Xaa Arg Met Xaa 50 55 60 Val
Gly Gly Val Glu His 65 70 109 9 PRT hepatitis C virus MISC_FEATURE
(1)..(1) Xaa is Gln, Ser or Tyr 109 Xaa Leu Xaa Asn Xaa Asn Gly Ser
Trp 1 5 110 8 PRT hepatitis C virus MISC_FEATURE (2)..(2) Xaa is
Ile or Val 110 Leu Xaa Asn Xaa Asn Gly Ser Trp 1 5 111 9 PRT
hepatitis C virus MISC_FEATURE (4)..(4) Xaa is Leu or Ile 111 Ser
Trp His Xaa Asn Xaa Thr Ala Leu 1 5 112 8 PRT hepatitis C virus
MISC_FEATURE (3)..(3) Xaa is Leu or Ile 112 Trp His Xaa Asn Xaa Thr
Ala Leu 1 5 113 9 PRT hepatitis C virus 113 Gln Leu Ile Asn Thr Asn
Gly Ser Trp 1 5 114 8 PRT hepatitis C virus 114 Leu Ile Asn Thr Asn
Gly Ser Trp 1 5 115 9 PRT hepatitis C virus 115 Ser Trp His Ile Asn
Ser Thr Ala Leu 1 5 116 8 PRT hepatitis C virus 116 Trp His Ile Asn
Ser Thr Ala Leu 1 5 117 8 PRT hepatitis C virus 117 Leu Gly Lys Val
Ile Asp Thr Leu 1 5 118 21 PRT hepatitis C virus 118 Gly Gly Val
Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu 1 5 10 15 Asp
Gly Val Asn Tyr 20 119 11 PRT hepatitis C virus MISC_FEATURE
(1)..(1) Xaa is Thr or Ser 119 Xaa Xaa Xaa Leu Xaa Cys Pro Thr Asp
Cys Phe 1 5 10 120 9 PRT hepatitis C virus MISC_FEATURE (4)..(4)
Xaa is His or Tyr 120 Phe Arg Lys Xaa Pro Xaa Xaa Thr Tyr 1 5 121 8
PRT hepatitis C virus MISC_FEATURE (1)..(1) Xaa is Trp or Leu 121
Xaa Xaa Thr Pro Arg Cys Xaa Xaa 1 5 122 8 PRT hepatitis C virus
MISC_FEATURE (1)..(1) Xaa is Leu, Met or Ile 122 Xaa Xaa Asp Tyr
Pro Tyr Arg Leu 1 5 123 8 PRT hepatitis C virus MISC_FEATURE
(1)..(1) Xaa is Val or Ile 123 Xaa Asp Tyr Pro Tyr Arg Leu Trp 1 5
124 8 PRT hepatitis C virus 124 Tyr Pro Tyr Arg Leu Trp His Tyr 1 5
125 8 PRT hepatitis C virus MISC_FEATURE (8)..(8) Xaa is Ile, Val,
Phe or Leu 125 Leu Trp His Tyr Pro Cys Thr Xaa 1 5 126 8 PRT
hepatitis C virus MISC_FEATURE (1)..(1) Xaa is Ile, Val, Phe or Leu
126 Xaa Asn Xaa Xaa Xaa Phe Lys Xaa 1 5 127 8 PRT hepatitis C virus
MISC_FEATURE (1)..(1) Xaa is Tyr or Phe 127 Xaa Xaa Xaa Phe Lys Xaa
Arg Met 1 5 128 8 PRT hepatitis C virus MISC_FEATURE (1)..(1) Xaa
is Ile or Val 128 Xaa Phe Lys Xaa Arg Met Xaa Val 1 5 129 8 PRT
hepatitis C virus MISC_FEATURE (1)..(1) Xaa is Ile, Val or Ala 129
Xaa Arg Met Xaa Val Gly Gly Val 1 5 130 22 PRT hepatitis C virus
MISC_FEATURE (2)..(2) Xaa is Gly or Arg 130 Ile Xaa Xaa Xaa Xaa Asn
Xaa Xaa Xaa Xaa Leu Xaa Cys Pro Thr Asp 1 5 10 15 Cys Phe Arg Lys
Xaa Pro 20 131 20 PRT hepatitis C virus MISC_FEATURE (7)..(7) Xaa
is His or Tyr 131 Thr Asp Cys Phe Arg Lys Xaa Pro Xaa Xaa Thr Tyr
Xaa Xaa Cys Gly 1 5 10 15 Xaa Gly Pro Xaa 20 132 20 PRT hepatitis C
virus MISC_FEATURE (1)..(1) Xaa is Ser, Thr, Ile or Leu 132 Xaa Xaa
Cys Gly Xaa Gly Pro Xaa Xaa Thr Pro Arg Cys Xaa Xaa Asp 1 5 10 15
Tyr Pro Tyr Arg 20 133 20 PRT hepatitis C virus MISC_FEATURE
(2)..(2) Xaa is Leu, Met or Ile 133 Cys Xaa Xaa Asp Tyr Pro Tyr Arg
Leu Trp His Tyr Pro Cys Thr Xaa 1 5 10 15 Asn Xaa Xaa Xaa 20 134 20
PRT hepatitis C virus MISC_FEATURE (4)..(4) Xaa is Ile, Val, Phe or
Leu 134 Pro Cys Thr Xaa Asn Xaa Xaa Xaa Phe Lys Xaa Arg Met Xaa Val
Gly 1 5 10 15 Gly Val Glu His 20 135 8 PRT hepatitis C virus 135
Val Ala Lys Ala Val Asp Phe Val 1 5 136 8 PRT hepatitis C virus 136
Val Ala Lys Ala Val Asp Phe Ile 1 5 137 8 PRT hepatitis C virus 137
Val Glu Ser Met Glu Thr Thr Met 1 5 138 8 PRT hepatitis C virus 138
Ala Val Pro Gln Thr Phe Gln Val 1 5 139 8 PRT hepatitis C virus 139
Tyr Ala Ala Gln Gly Tyr Lys Val 1 5 140 9 PRT hepatitis C virus 140
Val Leu Val Leu Asn Pro Ser Val Ala 1 5 141 8 PRT hepatitis C virus
141 Tyr Met Ser Lys Ala His Gly Val 1 5 142 8 PRT hepatitis C virus
142 Ile Arg Thr Gly Val Arg Thr Ile 1 5 143 8 PRT hepatitis C virus
143 Tyr Ser Thr Tyr Gly Lys Phe Leu 1 5 144 8 PRT hepatitis C virus
144 Ile Leu Gly Ile Gly Thr Val Leu 1 5 145 8 PRT hepatitis C virus
145 Val Thr Val Pro His Pro Asn Ile 1 5 146 8 PRT hepatitis C virus
146 Ile Pro Phe Tyr Gly Lys Ala Ile 1 5 147 8 PRT hepatitis C virus
147 Phe Tyr Gly Lys Ala Ile Pro Ile 1 5 148 8 PRT hepatitis C virus
148 Val Ile Lys Gly Gly Arg His Leu 1 5 149 8 PRT hepatitis C virus
149 Ile Lys Gly Gly Arg His Leu Ile 1 5 150 8 PRT hepatitis C virus
150 Phe Cys His Ser Lys Lys Lys Cys 1 5 151 8 PRT hepatitis C virus
151 Cys Asp Glu Leu Ala Ala Lys Leu 1 5 152 9 PRT hepatitis C virus
152 Leu Ala Ala Lys Leu Ser Gly Phe Gly 1 5 153 8 PRT hepatitis C
virus 153 Ser Gly Phe Gly Ile Asn Ala Val 1 5 154 8 PRT hepatitis C
virus 154 Phe Gly Ile Asn Ala Val Ala Tyr 1 5 155 8 PRT hepatitis C
virus 155 Tyr Arg Gly Leu Asp Val Ser Val 1 5 156 8 PRT hepatitis C
virus 156 Val Ile Pro Thr Ser Gly Asp Val 1 5 157 8 PRT hepatitis C
virus 157 Ile Pro Thr Ser Gly Asp Val Val 1 5 158 8 PRT hepatitis C
virus 158 Val Val Val Ala Thr Asp Ala Leu 1 5 159 8 PRT hepatitis C
virus 159 Val Val Ala Thr Asp Ala Leu Met 1 5 160 8 PRT hepatitis C
virus 160 Met Thr Gly Phe Thr Gly Asp Phe 1 5 161 8 PRT hepatitis C
virus 161 Phe Thr Gly Asp Phe Asp Ser Val 1 5 162 8 PRT hepatitis C
virus 162 Val Ile Asp Cys Asn Thr Cys Val 1 5 163 9 PRT hepatitis C
virus 163 Ala Leu Met Gly Tyr Ile Pro Leu Val 1 5 164 43 PRT
hepatitis C virus 164 Tyr Gln Val Arg Asn Ser Thr Gly Leu Tyr His
Val Thr Asn Asp Cys 1 5 10 15 Pro Asn Ser Ser Ile Val Tyr Glu Ala
His Asp Ala Ile Leu His Thr 20 25 30 Pro Gly Cys Val Pro Cys Val
Arg Glu Gly Asn 35 40 165 42 PRT hepatitis C virus 165 Gln Val Arg
Asn Ser Thr Gly Leu Tyr His Val Thr Asn Asp Cys Pro 1 5 10 15 Asn
Ser Ser Ile Val Tyr Glu Ala His Asp Ala Ile Leu His Thr Pro 20 25
30 Gly Cys Val Pro Cys Val Arg Glu Gly Asn 35 40 166 10 PRT
hepatitis C virus 166 Lys Leu Val Ala Leu Gly Ile Asn Ala Val 1 5
10 167 8 PRT hepatitis C virus 167 Ala Ser Arg Cys Trp Val Ala Met
1 5 168 13 PRT hepatitis C virus 168 Leu Met Ala Leu Thr Leu Ser
Pro Tyr Tyr Lys Arg Tyr 1 5 10 169 13 PRT hepatitis C virus 169 Arg
Ala Leu Ala His Gly Val Arg Val Leu Glu Asp Gly 1 5 10 170 7 PRT
hepatitis C virus 170 Arg Met Ala Trp Asp Met Met 1 5 171 9 PRT
hepatitis C virus 171 Pro Thr Asp Cys Phe Arg Lys His Pro 1 5 172 7
PRT hepatitis C virus 172 Tyr Pro Tyr Arg Leu Trp His 1 5 173 7 PRT
hepatitis C virus 173 Gly Lys Ser Thr Lys Val Pro 1 5 174 6 PRT
hepatitis C virus 174 Pro Ser Val Ala Ala Thr 1 5 175 9 PRT
hepatitis C virus 175 Ile Gly Thr Val Leu Asp Gln Ala Glu 1 5 176 6
PRT hepatitis C virus 176 Ala Val Ala Tyr Tyr Arg 1 5 177 9 PRT
hepatitis C virus 177 Thr Gly Asp Phe Asp Ser Val Ile Asp 1 5 178
278 PRT hepatitis C virus 178 Gly Val Ala Lys Ala Val Asp Phe Val
Pro Val Glu Ser Met Glu Thr 1 5 10 15 Thr Met Arg Ser Pro Val Phe
Thr Asp Asn Ser Ser Pro Pro Ala Val 20 25 30 Pro Gln Thr Phe Gln
Val Ala His Leu His Ala Pro Thr Gly Ser Gly 35 40 45 Lys Ser Thr
Lys Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr Lys Val 50 55 60 Leu
Val Leu Asn Pro Ser Val Ala Ala Thr Leu Gly Phe Gly Ala Tyr 65 70
75 80 Met Ser Lys Ala His Gly Val Asp Pro Asn Ile Arg Thr Gly Val
Arg 85 90 95 Thr Ile Thr Thr Gly Ala Pro Ile Thr Tyr Ser Thr Tyr
Gly Lys Phe 100 105 110 Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala Tyr
Asp Ile Ile Ile Cys 115 120 125 Asp Glu Cys His Ser Ile Asp Ser Thr
Ser Ile Leu Gly Ile Gly Thr 130 135 140 Val Leu Asp Gln Ala Glu Thr
Ala Gly Ala Arg Leu Val Val Leu Ala 145 150 155 160 Thr Ala Thr Pro
Pro Gly Ser Val Thr Val Pro His Pro Asn Ile Glu 165 170 175 Glu Val
Ala Leu Ser Ser Thr Gly Glu Ile Pro Phe Tyr Gly Lys Ala 180 185 190
Ile Pro Ile Glu Val Ile Lys Gly Gly Arg His Leu Ile Phe Cys His 195
200 205 Ser Lys Lys Lys Cys Asp Glu Leu Ala Ala Lys Leu Ser Gly Phe
Gly 210 215 220 Ile Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser
Val Ile Pro 225 230 235 240 Thr Ser Gly Asp Val Val Val Val Ala Thr
Asp Ala Leu Met Thr Gly 245 250 255 Phe Thr Gly Asp Phe Asp Ser Val
Ile Asp Cys Asn Thr Cys Val Thr 260 265 270 Gln Thr Val Asp Phe Ser
275 179 450 PRT hepatitis C virus 179 Met Ser Thr Asn Pro Lys Pro
Gln Arg Lys Thr Lys Arg Asn Thr Asn 1 5 10 15 Arg Arg Pro Gln Asp
Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 20 25 30 Gly Val Tyr
Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 35 40 45 Thr
Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 50 55
60 Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly
65 70 75 80 Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala
Gly Trp 85 90 95 Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly
Pro Thr Asp Pro 100 105 110 Arg Arg Arg Ser Arg Asn Leu Gly Lys Val
Ile Asp Thr Leu Thr Cys 115 120 125 Gly Phe Ala Asp Leu Met Gly Tyr
Ile Pro Leu Val Gly Ala Pro Leu 130 135 140 Gly Gly Ala Ala Arg Ala
Leu Ala His Gly Val Arg Val Leu Glu Asp 145 150 155 160 Gly Val Asn
Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 165 170 175 Phe
Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 180 185
190 Gln Val Arg Asn Ser Ser Gly Leu Tyr His Val Thr Asn Asp Cys Pro
195 200 205 Asn Ser Ser Val Val Tyr Glu Ala Ala Asp Ala Ile Leu His
Thr Pro 210 215 220 Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser
Arg Cys Trp Val 225 230 235 240 Ala Val Thr Pro Thr Val Ala Thr Arg
Asp Gly Lys Leu Pro Thr Thr 245 250 255 Gln Leu Arg Arg His Ile Asp
Leu Leu Val Gly Ser Ala Thr Leu Cys 260 265 270 Ser Ala Leu Tyr Val
Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly 275 280 285 Gln Leu Phe
Thr Phe Ser Pro Arg His His Trp Thr Thr Gln Asp Cys 290 295 300 Asn
Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 305 310
315 320 Asn Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Val Val Ala
Gln 325 330 335 Leu Leu Arg Ile Pro Gln Ala Ile Met Asp Met Ile Ala
Gly Ala His 340 345 350 Trp Gly Val Leu Ala Gly Ile Lys Tyr Phe Ser
Met Val Gly Asn Trp 355 360 365 Ala Lys Val Leu Val Val Leu Leu Leu
Phe Ala Gly Val Asp Ala Glu 370 375 380 Thr His Val Thr Gly Gly Asn
Ala Gly Arg Thr Thr Ala Gly Leu Val 385 390 395 400 Gly Leu Leu Thr
Pro Gly Ala Lys Gln Asn Ile Gln Leu Ile Asn Thr 405 410 415 Asn Gly
Ser Trp His Ile Asn Ser Thr Ala Leu Asn
Cys Asn Glu Ser 420 425 430 Leu Asn Thr Gly Trp Leu Ala Gly Leu Phe
Tyr Gln His Lys Phe Asn 435 440 445 Ser Ser 450 180 450 PRT
hepatitis C virus 180 Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr
Lys Arg Asn Thr Asn 1 5 10 15 Arg Arg Pro Gln Asp Val Lys Phe Pro
Gly Gly Gly Gln Ile Val Gly 20 25 30 Gly Val Tyr Leu Leu Pro Arg
Arg Gly Pro Arg Leu Gly Val Arg Ala 35 40 45 Thr Arg Lys Thr Ser
Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 50 55 60 Ile Pro Lys
Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 65 70 75 80 Tyr
Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 85 90
95 Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro
100 105 110 Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu
Thr Cys 115 120 125 Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val
Gly Ala Pro Leu 130 135 140 Gly Gly Ala Ala Arg Ala Leu Ala His Gly
Val Arg Val Leu Glu Asp 145 150 155 160 Gly Val Asn Tyr Ala Thr Gly
Asn Leu Pro Gly Cys Ser Phe Ser Ile 165 170 175 Phe Leu Leu Ala Leu
Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 180 185 190 Gln Val Arg
Asn Ser Thr Gly Leu Tyr His Val Thr Asn Asp Cys Pro 195 200 205 Asn
Ser Ser Ile Val Tyr Glu Ala Ala Asp Ala Ile Leu His Thr Pro 210 215
220 Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ala Ser Arg Cys Trp Val
225 230 235 240 Ala Met Thr Pro Thr Val Ala Thr Arg Asp Gly Lys Leu
Pro Ala Thr 245 250 255 Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly
Ser Ala Thr Leu Cys 260 265 270 Ser Ala Leu Tyr Val Gly Asp Leu Cys
Gly Ser Val Phe Leu Val Gly 275 280 285 Gln Leu Phe Thr Phe Ser Pro
Arg Arg His Trp Thr Thr Gln Gly Cys 290 295 300 Asn Cys Ser Ile Tyr
Pro Gly His Ile Thr Gly His Arg Met Ala Trp 305 310 315 320 Asp Met
Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Met Ala Gln 325 330 335
Leu Leu Arg Ile Pro Gln Ala Ile Leu Asp Met Ile Ala Gly Ala His 340
345 350 Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser Met Val Gly Asn
Trp 355 360 365 Ala Lys Val Leu Val Val Leu Leu Leu Phe Ala Gly Val
Asp Ala Glu 370 375 380 Thr His Val Thr Gly Gly Ser Ala Gly His Thr
Val Ser Gly Phe Val 385 390 395 400 Ser Leu Leu Ala Pro Gly Ala Lys
Gln Asn Val Gln Leu Ile Asn Thr 405 410 415 Asn Gly Ser Trp His Leu
Asn Ser Thr Ala Leu Asn Cys Asn Asp Ser 420 425 430 Leu Asn Thr Gly
Trp Leu Ala Gly Leu Phe Tyr His His Lys Phe Asn 435 440 445 Ser Ser
450 181 450 PRT hepatitis C virus 181 Met Ser Thr Ile Pro Lys Pro
Gln Arg Lys Thr Lys Arg Asn Thr Asn 1 5 10 15 Arg Arg Pro Gln Asp
Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 20 25 30 Gly Val Tyr
Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 35 40 45 Thr
Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 50 55
60 Ile Pro Lys Val Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly
65 70 75 80 Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala
Gly Trp 85 90 95 Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly
Pro Thr Asp Pro 100 105 110 Arg Arg Arg Ser Arg Asn Leu Gly Lys Val
Ile Asp Thr Leu Thr Cys 115 120 125 Gly Phe Ala Asp Leu Met Gly Tyr
Ile Pro Leu Val Gly Ala Pro Leu 130 135 140 Gly Gly Ala Ala Arg Ala
Leu Ala His Gly Val Arg Val Leu Glu Asp 145 150 155 160 Gly Val Asn
Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 165 170 175 Phe
Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala Tyr 180 185
190 Gln Val Arg Asn Ser Thr Gly Leu Tyr His Val Thr Asn Asp Cys Pro
195 200 205 Asn Ser Ser Ile Val Tyr Glu Ala His Asp Ala Ile Leu His
Thr Pro 210 215 220 Gly Cys Val Pro Cys Val Arg Glu Gly Asn Val Ser
Arg Cys Trp Val 225 230 235 240 Ala Met Thr Pro Thr Val Ala Thr Arg
Asp Gly Lys Leu Pro Ala Thr 245 250 255 Gln Leu Arg Arg His Ile Asp
Leu Leu Val Gly Ser Ala Thr Leu Cys 260 265 270 Ser Ala Leu Tyr Val
Gly Asp Leu Cys Gly Ser Val Phe Leu Ile Gly 275 280 285 Gln Leu Phe
Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln Gly Cys 290 295 300 Asn
Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala Trp 305 310
315 320 Asp Met Met Met Asn Trp Ser Pro Thr Ala Ala Leu Val Met Ala
Gln 325 330 335 Leu Leu Arg Ile Pro Gln Ala Ile Leu Asp Met Ile Ala
Gly Ala His 340 345 350 Trp Gly Val Leu Ala Gly Ile Ala Tyr Phe Ser
Met Val Gly Asn Trp 355 360 365 Ala Lys Val Leu Val Val Leu Leu Leu
Phe Ala Gly Val Asp Ala Glu 370 375 380 Thr Ile Val Ser Gly Gly Gln
Ala Ala Arg Ala Met Ser Gly Leu Val 385 390 395 400 Ser Leu Phe Thr
Pro Gly Ala Lys Gln Asn Ile Gln Leu Ile Asn Thr 405 410 415 Asn Gly
Ser Trp His Ile Asn Ser Thr Ala Leu Asn Cys Asn Glu Ser 420 425 430
Leu Asn Thr Gly Trp Leu Ala Gly Leu Ile Tyr Gln His Lys Phe Asn 435
440 445 Ser Ser 450 182 181 PRT hepatitis C virus 182 Thr Cys Gly
Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala 1 5 10 15 Pro
Leu Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu 20 25
30 Glu Asp Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe
35 40 45 Ser Ile Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro
Ala Ser 50 55 60 Ala Tyr Gln Val Arg Asn Ser Ser Gly Leu Tyr His
Val Thr Asn Asp 65 70 75 80 Cys Pro Asn Ser Ser Ile Val Tyr Glu Ala
Ala Asp Ala Ile Leu His 85 90 95 Thr Pro Gly Cys Val Pro Cys His
Arg Glu Gly Val Ala Ser Arg Cys 100 105 110 Trp Val Ala Met Thr Pro
Thr Val Ala Thr Arg Asp Gly Lys Leu Thr 115 120 125 Ala Thr Gln Leu
Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr 130 135 140 Leu Cys
Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu 145 150 155
160 Val Gly Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr Gln
165 170 175 Gly Cys Asn Cys Ser 180 183 192 PRT hepatitis C virus
183 Thr Cys Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala
1 5 10 15 Pro Leu Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg
Val Leu 20 25 30 Glu Asp Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro
Gly Cys Ser Phe 35 40 45 Ser Ile Phe Leu Leu Ala Leu Leu Ser Cys
Leu Thr Val Pro Ala Ser 50 55 60 Ala His Gln Val Arg Asn Ser Thr
Gly Leu Tyr His Val Thr Asn Asp 65 70 75 80 Cys Pro Asn Ser Ser Ile
Val Tyr Glu Ala Ala Asp Ala Ile Leu His 85 90 95 Thr Pro Gly Cys
Val Pro Cys His Arg Glu Gly Val Ala Ser Arg Cys 100 105 110 Trp Val
Val Met Thr Pro Thr Val Ala Thr Arg Asp Gly Lys Leu Thr 115 120 125
Ala Thr Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr 130
135 140 Leu Cys Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe
Leu 145 150 155 160 Val Gly Gln Leu Phe Thr Phe Ser Pro Arg Arg His
Trp Thr Thr Gln 165 170 175 Gly Cys Asn Cys Ser Ile Tyr Pro Gly His
Ile Thr Gly His Arg Met 180 185 190 184 191 PRT hepatitis C virus
184 Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu
1 5 10 15 Gly Gly Arg Ala Arg Ala Leu Ala His Gly Val Arg Val Leu
Glu Asp 20 25 30 Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys
Ser Phe Ser Ile 35 40 45 Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr
Val Pro Ala Ser Ala Tyr 50 55 60 Gln Val Arg Asn Ser Thr Gly Leu
Tyr His Val Thr Asn Asp Cys Pro 65 70 75 80 Asn Ser Ser Ile Val Tyr
Glu Ala Ala Asp Ala Ile Leu His Ala Pro 85 90 95 Gly Cys Val Pro
Cys Val Arg Asp Gly Val Ala Ser Arg Cys Trp Val 100 105 110 Val Met
Thr Pro Thr Val Ala Lys Arg Asp Gly Lys Leu Thr Ala Thr 115 120 125
Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 130
135 140 Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ile Val Phe Leu Val
Gly 145 150 155 160 Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr
Thr Gln Asp Cys 165 170 175 Asn Cys Ser Ile Tyr Pro Gly His Ile Thr
Gly His Arg Met Ala 180 185 190 185 191 PRT hepatitis C virus 185
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 1 5
10 15 Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu
Asp 20 25 30 Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser
Phe Ser Ile 35 40 45 Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val
Pro Ala Ser Ala Tyr 50 55 60 Gln Val Arg Asn Ser Ser Gly Ile Tyr
His Val Thr Asn Asp Cys Pro 65 70 75 80 Asn Ser Ser Ile Val Tyr Glu
Thr Ala Asp Thr Ile Leu His Ser Pro 85 90 95 Gly Cys Val Pro Cys
Val Arg Glu Gly Asn Ala Lys Arg Cys Trp Pro 100 105 110 Val Ala Thr
Pro Thr Val Ala Thr Arg Asp Asn Lys Leu Pro Ala Thr 115 120 125 Gln
Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr Leu Cys 130 135
140 Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Gly
145 150 155 160 Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr Thr
Gln Asp Cys 165 170 175 Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly
His Arg Met Ala 180 185 190 186 192 PRT hepatitis C virus 186 Thr
Cys Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala 1 5 10
15 Pro Leu Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu
20 25 30 Glu Asp Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys
Ser Phe 35 40 45 Ser Leu Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr
Val Pro Ala Ser 50 55 60 Ala Tyr Gln Val Arg Asn Ser Thr Gly Leu
Tyr His Val Thr Asn Asp 65 70 75 80 Cys Pro Asn Ser Ser Ile Val Tyr
Glu Ala Ala Asp Ala Ile Leu His 85 90 95 Ala Pro Gly Cys Val Pro
Cys Val Arg Glu Gly Asn Ala Ser Arg Cys 100 105 110 Trp Val Ala Met
Thr Pro Thr Val Ala Thr Arg Asp Arg Lys Leu Thr 115 120 125 Ala Thr
Gln Leu Arg Arg His Ile Asp Leu Leu Val Gly Ser Ala Thr 130 135 140
Leu Cys Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ile Val Phe Leu 145
150 155 160 Val Gly Gln Leu Phe Thr Phe Ser Pro Arg Arg His Trp Thr
Thr Gln 165 170 175 Gly Cys Asn Cys Ser Ile Tyr Pro Gly His Ile Thr
Gly His Arg Met 180 185 190 187 450 PRT hepatitis C virus 187 Met
Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 1 5 10
15 Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly
20 25 30 Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val
Arg Ala 35 40 45 Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly
Arg Arg Gln Pro 50 55 60 Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg
Thr Trp Ala Gln Pro Gly 65 70 75 80 Tyr Pro Trp Pro Leu Tyr Gly Asn
Glu Gly Met Gly Trp Ala Gly Trp 85 90 95 Leu Leu Ser Pro Arg Gly
Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 100 105 110 Arg Arg Arg Ser
Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 115 120 125 Gly Phe
Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 130 135 140
Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 145
150 155 160 Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe
Ser Ile 165 170 175 Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Ile Pro
Ala Ser Ala Tyr 180 185 190 Glu Val Arg Asn Val Ser Gly Ile Tyr His
Val Thr Asn Asp Cys Ser 195 200 205 Asn Ser Ser Ile Val Tyr Glu Ala
Ala Asp Met Ile Met His Thr Pro 210 215 220 Gly Cys Val Pro Cys Val
Arg Glu Ser Asn Phe Ser Arg Cys Trp Val 225 230 235 240 Ala Leu Thr
Pro Thr Leu Ala Ala Arg Asn Ser Ser Ile Pro Thr Thr 245 250 255 Thr
Ile Arg Arg His Val Asp Leu Leu Val Gly Ala Ala Ala Leu Cys 260 265
270 Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Ser
275 280 285 Gln Leu Phe Thr Phe Ser Pro Arg Arg Tyr Glu Thr Val Gln
Asp Cys 290 295 300 Asn Cys Ser Ile Tyr Pro Gly His Val Ser Gly His
Arg Met Ala Trp 305 310 315 320 Asp Met Met Met Asn Trp Ser Pro Thr
Thr Ala Leu Val Val Ser Gln 325 330 335 Leu Leu Arg Ile Pro Gln Ala
Val Val Asp Met Val Ala Gly Ala His 340 345 350 Trp Gly Val Leu Ala
Gly Leu Ala Tyr Tyr Ser Met Val Gly Asn Trp 355 360 365 Ala Lys Val
Leu Ile Val Met Leu Leu Phe Ala Gly Val Asp Gly His 370 375 380 Thr
His Val Thr Gly Gly Arg Val Ala Ser Ser Thr Gln Ser Leu Val 385 390
395 400 Ser Trp Leu Ser Gln Gly Pro Ser Gln Lys Ile Gln Leu Val Asn
Thr 405 410 415 Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys
Asn Asp Ser 420 425 430 Leu Gln Thr Gly Phe Ile Ala Ala Leu Phe Tyr
Ala His Arg Phe Asn 435 440 445 Ala Ser 450 188 450 PRT hepatitis C
virus 188 Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn
Thr Asn 1 5 10 15 Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly
Gln Ile Val Gly 20 25 30 Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro
Arg Leu Gly Val Arg Ala 35 40 45 Thr Arg Lys Thr Ser Glu Arg Ser
Gln Pro Arg Gly Trp Arg Gln Pro 50 55 60 Ile Pro Lys Ala Arg Arg
Pro Glu Gly Arg Ala Trp Ala Gln Pro Gly 65 70 75 80 Tyr Pro Trp Pro
Leu Tyr Gly Asn Glu
Gly Leu Gly Trp Ala Gly Trp 85 90 95 Leu Leu Ser Pro Arg Gly Ser
Arg Pro Ser Trp Gly Pro Thr Asp Pro 100 105 110 Arg Arg Arg Ser Arg
Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 115 120 125 Gly Phe Ala
Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 130 135 140 Gly
Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 145 150
155 160 Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser
Ile 165 170 175 Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Ile Pro Ala
Ser Ala Tyr 180 185 190 Glu Val Arg Asn Val Ser Gly Ile Tyr His Val
Thr Asn Asp Cys Ser 195 200 205 Asn Ser Ser Ile Val Tyr Glu Ala Ala
Asp Met Ile Met His Thr Pro 210 215 220 Gly Cys Val Pro Cys Val Arg
Glu Asp Asn Ser Ser Arg Cys Trp Val 225 230 235 240 Ala Leu Thr Pro
Thr Leu Ala Ala Arg Asn Ala Ser Val Pro Thr Thr 245 250 255 Thr Ile
Arg Arg His Val Asp Leu Leu Val Gly Ala Ala Ala Phe Cys 260 265 270
Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Ser 275
280 285 Gln Leu Phe Thr Phe Ser Pro Arg Arg His Glu Thr Val Gln Asp
Cys 290 295 300 Asn Cys Ser Ile Tyr Pro Gly His Leu Ser Gly His Arg
Met Ala Trp 305 310 315 320 Asp Met Met Met Asn Trp Ser Pro Thr Thr
Ala Leu Val Val Ser Gln 325 330 335 Leu Leu Arg Ile Pro Gln Ala Val
Val Asp Met Val Ala Gly Ala His 340 345 350 Trp Gly Val Leu Ala Gly
Leu Ala Tyr Tyr Ser Met Val Gly Asn Trp 355 360 365 Ala Lys Val Leu
Ile Val Ala Leu Leu Phe Ala Gly Val Asp Gly Glu 370 375 380 Thr Tyr
Thr Ser Gly Gly Ala Ala Ser His Thr Thr Ser Thr Leu Ala 385 390 395
400 Ser Leu Phe Ser Pro Gly Ala Ser Gln Arg Ile Gln Leu Val Asn Thr
405 410 415 Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn
Asp Ser 420 425 430 Leu His Thr Gly Phe Leu Ala Ala Leu Phe Tyr Thr
His Arg Phe Asn 435 440 445 Ser Ser 450 189 450 PRT hepatitis C
virus 189 Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn
Thr Asn 1 5 10 15 Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly
Gln Ile Val Gly 20 25 30 Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro
Arg Leu Gly Val Arg Ala 35 40 45 Thr Arg Lys Thr Ser Glu Arg Ser
Gln Pro Arg Gly Arg Arg Gln Pro 50 55 60 Ile Pro Lys Ala Arg Gln
Pro Glu Gly Arg Ala Trp Ala Gln Pro Gly 65 70 75 80 Tyr Pro Trp Pro
Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 85 90 95 Leu Leu
Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 100 105 110
Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 115
120 125 Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro
Leu 130 135 140 Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val
Leu Glu Asp 145 150 155 160 Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro
Gly Cys Ser Phe Ser Ile 165 170 175 Phe Leu Leu Ala Leu Leu Ser Cys
Leu Thr Ile Pro Ala Ser Ala Tyr 180 185 190 Glu Val Arg Asn Val Ser
Gly Ile Tyr His Val Thr Asn Asp Cys Ser 195 200 205 Asn Ser Ser Ile
Val Tyr Glu Ala Ala Asp Val Ile Met His Thr Pro 210 215 220 Gly Cys
Val Pro Cys Val Arg Glu Gly Asn Ser Ser Arg Cys Trp Val 225 230 235
240 Ala Leu Thr Pro Thr Leu Ala Ala Arg Asp Ala Ser Val Pro Thr Thr
245 250 255 Thr Ile Arg Arg His Val Asp Leu Leu Val Gly Thr Ala Ala
Phe Cys 260 265 270 Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Ile
Phe Leu Val Ser 275 280 285 Gln Leu Phe Thr Phe Ser Pro Arg Arg His
Glu Thr Val Gln Asp Cys 290 295 300 Asn Cys Ser Ile Tyr Pro Gly His
Val Ser Gly His Arg Met Ala Trp 305 310 315 320 Asp Met Met Met Asn
Trp Ser Pro Thr Thr Ala Leu Val Val Ser Gln 325 330 335 Leu Leu Arg
Ile Pro Gln Ala Val Val Asp Met Val Ala Gly Ala His 340 345 350 Trp
Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser Met Val Gly Asn Trp 355 360
365 Ala Lys Val Leu Ile Val Ala Leu Leu Phe Ala Gly Val Asp Gly Ala
370 375 380 Thr Tyr Thr Ser Gly Gly Val Ala Gly Arg Thr Thr Ser Gly
Phe Thr 385 390 395 400 Ser Leu Phe Ser Ser Gly Ala Ser Gln Lys Ile
Gln Leu Val Asn Thr 405 410 415 Asn Gly Ser Trp His Ile Asn Arg Thr
Ala Leu Asn Cys Asn Asp Ser 420 425 430 Leu His Thr Gly Phe Leu Ala
Ala Leu Phe Tyr Thr His Lys Phe Asn 435 440 445 Ser Ser 450 190 450
PRT hepatitis C virus 190 Met Ser Thr Asn Pro Lys Pro Gln Arg Lys
Thr Lys Arg Asn Thr Asn 1 5 10 15 Arg Arg Pro Gln Asp Val Lys Phe
Pro Gly Gly Gly Gln Ile Val Gly 20 25 30 Gly Val Tyr Leu Leu Pro
Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 35 40 45 Thr Arg Lys Thr
Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 50 55 60 Ile Pro
Lys Ala Arg Arg Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Phe Gly Trp Ala Gly Trp 85
90 95 Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp
Pro 100 105 110 Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr
Leu Thr Cys 115 120 125 Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu
Val Gly Ala Pro Leu 130 135 140 Gly Gly Ala Ala Arg Ala Leu Ala His
Gly Val Arg Val Leu Glu Asp 145 150 155 160 Gly Val Asn Tyr Ala Thr
Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 165 170 175 Phe Leu Leu Ala
Leu Leu Ser Cys Leu Thr Thr Pro Ala Ser Ala Tyr 180 185 190 Glu Val
Arg Asn Val Ser Gly Ile Tyr His Val Thr Asn Asp Cys Ser 195 200 205
Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Leu Ile Met His Thr Pro 210
215 220 Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ser Ser Arg Cys Trp
Val 225 230 235 240 Ala Leu Thr Pro Thr Leu Ala Ala Arg Asn Ala Thr
Ile Pro Thr Ala 245 250 255 Thr Val Arg Arg His Val Asp Leu Leu Val
Gly Ala Ala Ala Phe Ser 260 265 270 Ser Ala Met Tyr Val Gly Asp Leu
Cys Gly Ser Val Phe Leu Val Ser 275 280 285 Gln Leu Phe Thr Phe Ser
Pro Arg Arg Tyr Glu Thr Ile Gln Asp Cys 290 295 300 Asn Cys Ser Ile
Tyr Pro Gly His Val Thr Gly His Arg Met Ala Trp 305 310 315 320 Asp
Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ser Gln 325 330
335 Leu Leu Arg Ile Pro Gln Ala Val Met Asp Met Val Val Gly Ala His
340 345 350 Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ala Met Val Gly
Asn Trp 355 360 365 Ala Lys Val Leu Ile Val Met Leu Leu Phe Ala Gly
Val Asp Gly Asp 370 375 380 Thr Tyr Ala Ser Gly Gly Ala Gln Gly Arg
Ser Thr Leu Gly Phe Thr 385 390 395 400 Ser Leu Phe Thr Pro Gly Ala
Ser Gln Lys Ile Gln Leu Ile Asn Thr 405 410 415 Asn Gly Ser Trp His
Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 420 425 430 Leu Asn Thr
Gly Phe Leu Ala Ala Leu Phe Tyr Thr His Arg Phe Asn 435 440 445 Ala
Ser 450 191 450 PRT hepatitis C virus 191 Met Ser Thr Asn Pro Lys
Pro Gln Arg Lys Thr Lys Arg Asn Thr Tyr 1 5 10 15 Arg Arg Pro Gln
Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 20 25 30 Gly Val
Tyr Val Leu Pro Arg Arg Gly Pro Thr Leu Gly Val Arg Ala 35 40 45
Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 50
55 60 Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Ala Trp Ala Gln Pro
Gly 65 70 75 80 Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp
Ala Gly Trp 85 90 95 Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp
Gly Pro Thr Asp Pro 100 105 110 Arg Arg Arg Ser Arg Asn Leu Gly Lys
Val Ile Asp Thr Leu Thr Cys 115 120 125 Gly Phe Ala Asp Leu Met Gly
Tyr Ile Pro Leu Val Gly Ala Pro Leu 130 135 140 Gly Gly Ala Ala Arg
Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 145 150 155 160 Gly Val
Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 165 170 175
Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Ile Pro Ala Ser Ala Tyr 180
185 190 Gln Val Arg Asn Ala Ser Gly Leu Tyr His Val Thr Asn Asp Cys
Ser 195 200 205 Asn Ser Ser Ile Val Tyr Glu Ala Ala Gly Met Ile Met
His Thr Pro 210 215 220 Gly Cys Val Pro Cys Val Arg Glu Asn Asn Ala
Ser Arg Cys Trp Val 225 230 235 240 Ala Leu Thr Pro Thr Leu Ala Ala
Arg Asn Thr Ser Ile Pro Thr Thr 245 250 255 Thr Ile Arg Arg His Val
Asp Leu Leu Val Gly Ala Ala Ala Phe Cys 260 265 270 Ser Ala Met Tyr
Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Ser 275 280 285 Gln Leu
Phe Thr Phe Ser Pro Arg Arg Tyr Glu Thr Val Gln Asp Cys 290 295 300
Asn Cys Ser Ile Tyr Pro Gly His Val Ser Gly His Arg Met Ala Trp 305
310 315 320 Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val
Ser Gln 325 330 335 Leu Leu Arg Ile Pro Gln Ala Val Val Asp Met Val
Ala Gly Ala His 340 345 350 Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr
Ser Met Val Gly Asn Trp 355 360 365 Ala Lys Val Leu Ile Val Met Leu
Leu Phe Ala Gly Val Asp Gly Val 370 375 380 Thr Tyr Thr Thr Gly Gly
Ser Gln Ala Arg His Thr Gln Ser Val Thr 385 390 395 400 Ser Phe Phe
Thr Gln Gly Pro Ala Gln Arg Ile Gln Leu Ile Asn Thr 405 410 415 Asn
Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Glu Ser 420 425
430 Leu Asn Thr Gly Phe Phe Ala Ala Leu Phe Tyr Ala His Lys Phe Asn
435 440 445 Ser Ser 450 192 450 PRT hepatitis C virus 192 Met Ser
Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Tyr 1 5 10 15
Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 20
25 30 Gly Val Tyr Val Leu Pro Arg Arg Gly Pro Thr Leu Gly Val Arg
Ala 35 40 45 Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg
Arg Gln Pro 50 55 60 Ile Pro Lys Ala Arg Arg Pro Glu Gly Arg Ala
Trp Ala Gln Pro Gly 65 70 75 80 Tyr Pro Trp Pro Leu Tyr Gly Asn Glu
Gly Leu Gly Trp Ala Gly Trp 85 90 95 Leu Leu Ser Pro Arg Gly Ser
Arg Pro Ser Trp Gly Pro Thr Asp Pro 100 105 110 Arg Arg Arg Ser Arg
Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 115 120 125 Gly Phe Ala
Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 130 135 140 Gly
Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 145 150
155 160 Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser
Ile 165 170 175 Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Ile Pro Ala
Ser Ala Tyr 180 185 190 Gln Val Arg Asn Arg Ser Gly Leu Tyr His Val
Thr Asn Asp Cys Ser 195 200 205 Asn Ser Ser Ile Val Tyr Glu Ala Ala
Gly Met Ile Met His Thr Pro 210 215 220 Gly Cys Val Pro Cys Val Arg
Glu Asn Asn Val Ser Arg Cys Trp Val 225 230 235 240 Ala Leu Thr Pro
Thr Leu Ala Ala Arg Asn Thr Ser Ile Pro Thr Thr 245 250 255 Thr Ile
Arg Arg His Val Asp Leu Leu Val Gly Ala Ala Ala Phe Cys 260 265 270
Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu Val Ser 275
280 285 Gln Leu Phe Thr Phe Ser Pro Arg Arg Tyr Glu Thr Val Gln Asp
Cys 290 295 300 Asn Cys Ser Ile Tyr Pro Gly His Val Ser Gly His Arg
Met Ala Trp 305 310 315 320 Asp Met Met Met Asn Trp Ser Pro Thr Thr
Ala Leu Val Val Ser Gln 325 330 335 Leu Leu Arg Ile Pro Gln Ala Val
Val Asp Met Val Ala Gly Ala His 340 345 350 Trp Gly Val Leu Ala Gly
Leu Ala Tyr Tyr Ser Met Val Gly Asn Trp 355 360 365 Ala Lys Val Leu
Ile Val Met Leu Leu Phe Ala Gly Val Asp Gly Val 370 375 380 Thr Tyr
Thr Thr Gly Gly Ser Gln Ala Arg His Thr Gln Gly Val Ala 385 390 395
400 Ser Phe Phe Thr Pro Gly Pro Ala Gln Lys Ile Gln Leu Ile Asn Thr
405 410 415 Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn
Glu Ser 420 425 430 Leu Asn Thr Gly Phe Phe Ala Ala Leu Phe Tyr Ala
His Lys Phe Asn 435 440 445 Ser Ser 450 193 450 PRT hepatitis C
virus 193 Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn
Thr Asn 1 5 10 15 Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly
Gln Ile Val Gly 20 25 30 Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro
Arg Leu Gly Val Arg Ala 35 40 45 Pro Arg Lys Thr Ser Glu Arg Ser
Gln Pro Arg Gly Arg Arg Gln Pro 50 55 60 Ile Pro Lys Ala Arg Arg
Pro Glu Gly Arg Thr Trp Ala Gln Pro Gly 65 70 75 80 Tyr Pro Trp Pro
Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 85 90 95 Leu Leu
Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 100 105 110
Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 115
120 125 Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro
Leu 130 135 140 Gly Gly Ala Ala Arg Ala Leu Ala His Gly Val Arg Val
Leu Glu Asp 145 150 155 160 Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro
Gly Cys Ser Phe Ser Ile 165 170 175 Phe Leu Leu Ala Leu Leu Ser Cys
Leu Thr Thr Pro Ala Ser Ala Tyr 180 185 190 Glu Val His Asn Val Ser
Gly Ile Tyr His Val Thr Asn Asp Cys Ser 195 200 205 Asn Ala Ser Ile
Val Tyr Glu Ala Ala Asp Leu Ile Met His Thr Pro 210 215 220 Gly Cys
Val Pro Cys Val Arg Glu Gly Asn Ser Ser Arg Cys Trp Val 225 230 235
240 Ala Leu Thr Pro Thr Leu Ala Ala Arg Asn Val Thr Ile Pro Thr Thr
245 250 255 Thr Ile Arg Arg His Val Asp Leu Leu Val Gly Ala Ala Ala
Phe Cys
260 265 270 Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Ser Val Phe Leu
Val Ser 275 280 285 Gln Leu Phe Thr Phe Ser Pro Arg Arg His Val Thr
Leu Gln Asp Cys 290 295 300 Asn Cys Ser Ile Tyr Pro Gly His Val Ser
Gly His Arg Met Ala Trp 305 310 315 320 Asp Met Met Met Asn Trp Ser
Pro Thr Thr Ala Leu Val Val Ser Gln 325 330 335 Leu Leu Arg Ile Pro
Gln Ala Val Val Asp Met Val Ala Gly Ala His 340 345 350 Trp Gly Val
Leu Ala Gly Leu Ala Tyr Tyr Ser Met Ala Gly Asn Trp 355 360 365 Ala
Lys Val Leu Ile Val Met Leu Leu Phe Ala Gly Val Asp Gly Asp 370 375
380 Thr His Val Thr Gly Gly Ala Gln Ala Lys Thr Thr Asn Arg Leu Val
385 390 395 400 Ser Met Phe Ala Ser Gly Pro Ser Gln Lys Ile Gln Leu
Ile Asn Thr 405 410 415 Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu
Asn Cys Asn Asp Ser 420 425 430 Leu Gln Thr Gly Phe Leu Ala Ala Leu
Phe Tyr Thr His Ser Phe Asn 435 440 445 Ser Ser 450 194 450 PRT
hepatitis C virus 194 Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr
Lys Arg Asn Thr Asn 1 5 10 15 Arg Arg Pro Gln Asp Val Lys Phe Pro
Gly Gly Gly Gln Ile Val Gly 20 25 30 Gly Val Tyr Leu Leu Pro Arg
Arg Gly Pro Arg Leu Gly Val Arg Ala 35 40 45 Thr Arg Lys Thr Ser
Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 50 55 60 Ile Pro Lys
Ala Arg Gln Pro Glu Gly Arg Ala Trp Ala Gln Pro Gly 65 70 75 80 Tyr
Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 85 90
95 Leu Leu Ser Pro Tyr Gly Ser Arg Pro Arg Trp Gly Pro Thr Asp Pro
100 105 110 Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu
Thr Cys 115 120 125 Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val
Gly Ala Pro Leu 130 135 140 Gly Gly Ala Ala Arg Ala Leu Ala His Gly
Val Arg Val Leu Glu Asp 145 150 155 160 Gly Val Asn Tyr Ala Thr Gly
Asn Leu Pro Gly Cys Ser Phe Ser Ile 165 170 175 Phe Leu Leu Ala Leu
Leu Ser Cys Leu Thr Val Pro Val Ser Thr Tyr 180 185 190 Glu Val Arg
Asn Val Ser Gly Val Tyr His Val Thr Asn Asp Cys Ser 195 200 205 Asn
Ser Ser Ile Val Tyr Glu Ala Ala Asp Met Ile Met His Thr Pro 210 215
220 Gly Cys Val Pro Cys Val Arg Glu Gly Asn Ser Ser Arg Cys Trp Val
225 230 235 240 Ala Leu Thr Pro Thr Leu Ala Ala Arg Asn Ser Ser Ile
Pro Thr Thr 245 250 255 Thr Ile Arg Arg His Val Asp Leu Leu Val Gly
Ala Ala Ala Leu Cys 260 265 270 Ser Ala Met Tyr Val Gly Asp Leu Cys
Gly Ser Val Phe Leu Val Ser 275 280 285 Gln Leu Phe Thr Phe Ser Pro
Arg Arg Tyr Glu Thr Val Gln Asp Cys 290 295 300 Asn Cys Ser Leu Tyr
Pro Gly His Val Ser Gly His Arg Met Ala Trp 305 310 315 320 Asp Met
Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ser Gln 325 330 335
Leu Leu Arg Ile Pro Gln Ala Val Val Asp Met Val Val Gly Ala His 340
345 350 Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser Met Val Gly Asn
Trp 355 360 365 Ala Lys Val Leu Ile Val Met Leu Leu Phe Ala Gly Val
Asp Gly Thr 370 375 380 Thr Tyr Val Ser Val Gly His Ala Ser Gln Thr
Thr Arg Arg Val Ala 385 390 395 400 Ser Phe Phe Ser Pro Gly Ser Ala
Gln Lys Ile Gln Leu Val Asn Thr 405 410 415 Asn Gly Ser Trp His Ile
Asn Arg Thr Ala Leu Asn Cys Asn Glu Ser 420 425 430 Ile Asn Thr Gly
Phe Phe Ala Ala Leu Phe Tyr Val Lys Lys Phe Asn 435 440 445 Ser Ser
450 195 450 PRT hepatitis C virus 195 Met Ser Thr Asn Gly Lys Pro
Gln Arg Lys Thr Lys Arg Asn Thr Asn 1 5 10 15 Arg Arg Pro Gln Asp
Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 20 25 30 Gly Val Tyr
Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 35 40 45 Thr
Arg Lys Thr Trp Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 50 55
60 Ile Pro Lys Ala Arg Gln Pro Glu Gly Arg Ala Trp Ala Gln Pro Gly
65 70 75 80 Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala
Gly Trp 85 90 95 Leu Val Ser Pro Arg Gly Ser Arg Pro Asn Trp Gly
Pro Thr Asp Pro 100 105 110 Arg Arg Arg Ser Arg Asn Leu Gly Lys Val
Ile Asp Thr Leu Thr Cys 115 120 125 Gly Phe Ala Asp Leu Met Gly Tyr
Ile Pro Leu Val Gly Ala Pro Leu 130 135 140 Gly Gly Val Ala Arg Ala
Leu Ala His Gly Val Arg Val Leu Glu Asp 145 150 155 160 Gly Val Asn
Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 165 170 175 Phe
Leu Leu Ala Leu Leu Ser Cys Leu Thr Ile Pro Ala Ser Ala Tyr 180 185
190 Glu Val His Asn Val Ser Gly Ile Tyr His Val Thr Asn Asp Cys Ser
195 200 205 Asn Ser Ser Ile Val Tyr Glu Ala Ala Asp Met Ile Met His
Thr Pro 210 215 220 Gly Cys Val Pro Cys Val Arg Glu Asn Asn Ser Ser
Arg Cys Trp Val 225 230 235 240 Ala Leu Thr Pro Thr Leu Ala Ala Arg
Asn Asn Ser Val Pro Thr Ala 245 250 255 Thr Ile Arg Arg His Val Asp
Leu Leu Val Gly Ala Ala Ala Phe Cys 260 265 270 Ser Ala Met Tyr Val
Gly Asp Leu Cys Gly Ser Val Phe Leu Val Ser 275 280 285 Gln Leu Phe
Thr Phe Ser Pro Arg Arg Tyr Glu Thr Val Gln Asp Cys 290 295 300 Asn
Cys Ser Ile Tyr Pro Gly His Val Thr Gly His Arg Met Ala Trp 305 310
315 320 Asp Met Met Met Asn Trp Ser Pro Thr Thr Ala Leu Val Val Ser
Gln 325 330 335 Leu Leu Arg Ile Pro Gln Ala Val Val Asp Met Val Gly
Gly Ala His 340 345 350 Trp Gly Val Leu Ala Gly Leu Ala Tyr Tyr Ser
Met Val Gly Asn Trp 355 360 365 Ala Lys Val Leu Ile Val Met Leu Leu
Phe Ala Gly Val Asp Gly Ser 370 375 380 Thr Ile Val Ser Gly Gly Thr
Val Ala Arg Thr Thr His Ser Leu Ala 385 390 395 400 Ser Leu Phe Thr
Gln Gly Ala Ser Gln Lys Ile Gln Leu Ile Asn Thr 405 410 415 Asn Gly
Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp Ser 420 425 430
Leu Gln Thr Gly Phe Leu Ala Ser Leu Phe Tyr Ala His Arg Phe Asn 435
440 445 Ala Ser 450 196 258 PRT hepatitis C virus MISC_FEATURE
(71)..(71) Xaa is any amino acid 196 Met Ser Thr Asn Pro Lys Pro
Gln Arg Lys Thr Lys Arg Asn Thr Asn 1 5 10 15 Arg Arg Pro Gln Asp
Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 20 25 30 Gly Val Tyr
Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 35 40 45 Thr
Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 50 55
60 Ile Pro Lys Ala Arg Arg Xaa Glu Gly Arg Ser Trp Ala Gln Pro Gly
65 70 75 80 Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala
Gly Trp 85 90 95 Leu Leu Ser Pro Arg Gly Ser Arg Pro Asn Trp Gly
Pro Asp Gly Val 100 105 110 Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys
Ser Phe Ser Ile Phe Leu 115 120 125 Leu Ala Leu Leu Ser Cys Leu Thr
Val Pro Xaa Thr Ala His Glu Val 130 135 140 Arg Asn Ala Ser Gly Val
Tyr His Val Thr Asn Asp Cys Ser Asn Ser 145 150 155 160 Ser Ile Ile
Tyr Glu Met Asp Gly Met Ile Met His Tyr Pro Gly Cys 165 170 175 Val
Pro Cys Val Arg Glu Asp Asn His Leu Arg Cys Trp Met Ala Leu 180 185
190 Thr Pro Thr Leu Ala Val Lys Xaa Ala Ser Val Pro Thr Xaa Ala Ile
195 200 205 Arg Arg His Val Asp Leu Leu Val Gly Xaa Xaa Thr Phe Cys
Ser Ala 210 215 220 Met Tyr Val Xaa Asp Leu Cys Gly Ser Val Phe Leu
Ala Gly Gln Leu 225 230 235 240 Phe Thr Phe Ser Pro Arg Met His His
Thr Thr Gln Glu Cys Asn Cys 245 250 255 Ser Ile 197 258 PRT
hepatitis C virus MISC_FEATURE (75)..(75) Xaa is any amino acid 197
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 1 5
10 15 Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val
Gly 20 25 30 Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly
Val Arg Ala 35 40 45 Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg
Asp Arg Arg Gln Pro 50 55 60 Ile Pro Lys Ala Arg Gln Ser Asp Gly
Arg Xaa Trp Ala Gln Pro Gly 65 70 75 80 His Pro Trp Pro Leu Tyr Gly
Asn Glu Gly Cys Gly Trp Ala Gly Trp 85 90 95 Leu Leu Ser Pro Arg
Gly Ser Arg Pro Ser Trp Gly Pro Asp Gly Val 100 105 110 Asn Tyr Ala
Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile Phe Leu 115 120 125 Leu
Ala Phe Leu Ser Cys Leu Thr Val Pro Thr Thr Ala His Glu Val 130 135
140 Arg Asn Ala Ser Gly Val Tyr His Leu Thr Asn Asp Cys Ser Asn Ser
145 150 155 160 Ser Ile Ile Tyr Glu Met Ser Gly Met Ile Leu His Ala
Pro Gly Cys 165 170 175 Val Pro Cys Val Arg Glu Asn Asn Ser Ser Arg
Cys Trp Met Xaa Leu 180 185 190 Thr Pro Thr Leu Ala Val Lys Asp Ala
Asn Val Pro Thr Ala Ala Ile 195 200 205 Arg Arg His Val Asp Leu Leu
Val Gly Thr Ala Ala Phe Arg Ser Ala 210 215 220 Met Tyr Val Gly Asp
Leu Cys Gly Ser Val Phe Leu Val Gly Gln Leu 225 230 235 240 Phe Thr
Phe Ser Pro Arg Leu Tyr His Thr Thr Gln Glu Cys Asn Cys 245 250 255
Ser Ile 198 74 PRT hepatitis C virus 198 Met Ser Thr Asn Pro Lys
Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 1 5 10 15 Arg Arg Pro Gln
Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 20 25 30 Gly Val
Tyr Val Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 35 40 45
Ala Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 50
55 60 Ile Pro Lys Glu Arg Arg Pro Glu Gly Arg 65 70 199 319 PRT
hepatitis C virus MISC_FEATURE (152)..(152) Xaa is any amino acid
199 Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15 Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile
Val Gly 20 25 30 Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu
Gly Val Arg Ala 35 40 45 Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro
Arg Gly Arg Arg Gln Pro 50 55 60 Ile Pro Lys Ala Arg Arg Pro Glu
Gly Arg Ser Trp Ala Gln Pro Gly 65 70 75 80 Tyr Pro Trp Pro Leu Tyr
Ala Asn Glu Gly Cys Gly Trp Ala Gly Trp 85 90 95 Leu Leu Ser Pro
Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 100 105 110 Arg Arg
Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Leu 130
135 140 Gly Gly Ala Ser Arg Thr Leu Xaa His Gly Val Arg Val Leu Xaa
Gly 145 150 155 160 Gly Val Xaa Xaa Xaa Xaa Xaa Asn Leu Xaa Gly Cys
Ser Xaa Xaa Ile 165 170 175 Phe Leu Leu Xaa Leu Leu Ser Cys Leu Thr
Val Pro Thr Ser Ala Tyr 180 185 190 Glu Val His Ser Thr Thr Asp Gly
Tyr His Val Thr Asn Asp Cys Ser 195 200 205 Asn Gly Ser Ile Val Tyr
Glu Ala Lys Asp Ile Ile Leu His Thr Pro 210 215 220 Gly Xaa Val Pro
Cys Ile Arg Glu Gly Asn Ile Ser Arg Cys Trp Val 225 230 235 240 Pro
Leu Thr Pro Thr Leu Ala Ala Arg Ile Ala Asn Ala Pro Ile Asp 245 250
255 Glu Val Arg Arg His Val Asp Leu Leu Val Gly Ala Ala Val Phe Cys
260 265 270 Ser Ala Met Tyr Ile Gly Asp Leu Cys Gly Gly Val Phe Leu
Val Gly 275 280 285 Gln Leu Phe Thr Phe Thr Ser Arg Arg His Trp Thr
Val Gln Asp Cys 290 295 300 Asn Cys Ser Ile Tyr Ser Gly His Ile Thr
Gly His Xaa Xaa Xaa 305 310 315 200 450 PRT hepatitis C virus 200
Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 1 5
10 15 Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val
Gly 20 25 30 Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly
Val Arg Ala 35 40 45 Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg
Gly Arg Arg Gln Pro 50 55 60 Ile Pro Lys Asp Arg Arg Ser Thr Gly
Lys Ser Trp Gly Lys Pro Gly 65 70 75 80 Tyr Pro Trp Pro Leu Tyr Gly
Asn Glu Gly Leu Gly Trp Ala Gly Trp 85 90 95 Leu Leu Ser Pro Arg
Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 100 105 110 Arg His Arg
Ser Arg Asn Val Gly Lys Val Ile Asp Thr Leu Thr Cys 115 120 125 Gly
Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 130 135
140 Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp
145 150 155 160 Gly Val Asn Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser
Phe Ser Ile 165 170 175 Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Thr
Pro Val Ser Ala Ala 180 185 190 Glu Val Lys Asn Ile Ser Thr Gly Tyr
Met Val Thr Asn Asp Cys Thr 195 200 205 Asn Asp Ser Ile Thr Trp Gln
Leu Gln Ala Ala Val Leu His Val Pro 210 215 220 Gly Cys Val Pro Cys
Glu Lys Val Gly Asn Thr Ser Arg Cys Trp Ile 225 230 235 240 Pro Val
Ser Pro Asn Val Ala Val Gln Gln Pro Gly Ala Leu Thr Gln 245 250 255
Gly Leu Arg Thr His Ile Asp Met Val Val Met Ser Ala Thr Leu Cys 260
265 270 Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Gly Val Met Leu Ala
Ala 275 280 285 Gln Met Phe Ile Val Ser Pro Gln His His Trp Phe Val
Gln Asp Cys 290 295 300 Asn Cys Ser Ile Tyr Pro Gly Thr Ile Thr Gly
His Arg Met Ala Trp 305 310 315 320 Asp Met Met Met Asn Trp Ser Pro
Thr Ala Thr Met Ile Leu Ala Tyr 325 330 335 Ala Met Arg Val Pro Glu
Val Ile Ile Asp Ile Ile Gly Gly Ala His 340 345 350 Trp Gly Val Met
Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 355 360 365 Ala Lys
Val Val Val Ile Leu Leu Leu Ala Ala Gly Val Asp Ala Gln 370 375 380
Thr His Thr Val Gly Gly Ser Thr Ala His Asn Ala Arg Thr Leu Thr 385
390 395 400 Gly Met Phe Ser Leu Gly Ala Arg Gln Lys Ile Gln Leu Ile
Asn Thr 405
410 415 Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu Asn Cys Asn Asp
Ser 420 425 430 Leu His Thr Gly Phe Leu Ala Ser Leu Phe Tyr Thr His
Ser Phe Asn 435 440 445 Ser Ser 450 201 450 PRT hepatitis C virus
201 Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15 Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile
Val Gly 20 25 30 Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu
Gly Val Arg Ala 35 40 45 Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro
Arg Gly Arg Arg Gln Pro 50 55 60 Ile Pro Lys Asp Arg Arg Ser Thr
Gly Lys Ser Trp Gly Lys Pro Gly 65 70 75 80 Tyr Pro Trp Pro Leu Tyr
Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 85 90 95 Leu Leu Ser Pro
Arg Gly Ser Arg Pro Thr Trp Gly Pro Thr Asp Pro 100 105 110 Arg His
Arg Ser Arg Asn Leu Gly Arg Val Ile Asp Thr Ile Thr Cys 115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val 130
135 140 Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu
Asp 145 150 155 160 Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys
Ser Phe Ser Ile 165 170 175 Phe Leu Leu Ala Leu Leu Ser Cys Val Thr
Val Pro Val Ser Ala Val 180 185 190 Glu Val Arg Asn Ile Ser Ser Ser
Tyr Tyr Ala Thr Asn Asp Cys Ser 195 200 205 Asn Asn Ser Ile Thr Trp
Gln Leu Thr Asp Ala Val Leu His Leu Pro 210 215 220 Gly Cys Val Pro
Cys Glu Asn Asp Asn Gly Thr Leu His Cys Trp Ile 225 230 235 240 Gln
Val Thr Pro Asn Val Ala Val Lys His Arg Gly Ala Leu Thr Arg 245 250
255 Ser Leu Arg Thr His Val Asp Met Ile Val Met Ala Ala Thr Ala Cys
260 265 270 Ser Ala Leu Tyr Val Gly Asp Val Cys Gly Ala Val Met Ile
Leu Ser 275 280 285 Gln Ala Phe Met Val Ser Pro Gln Arg His Asn Phe
Thr Gln Glu Cys 290 295 300 Asn Cys Ser Ile Tyr Gln Gly His Ile Thr
Gly His Arg Met Ala Trp 305 310 315 320 Asp Met Met Leu Ser Trp Ser
Pro Thr Leu Thr Met Ile Leu Ala Tyr 325 330 335 Ala Ala Arg Val Pro
Glu Leu Val Leu Glu Ile Ile Phe Gly Gly His 340 345 350 Trp Gly Val
Val Phe Gly Leu Ala Tyr Phe Ser Met Gln Gly Ala Trp 355 360 365 Ala
Lys Val Ile Ala Ile Leu Leu Leu Val Ala Gly Val Asp Ala Thr 370 375
380 Thr Tyr Ser Ser Gly Gln Glu Ala Gly Arg Thr Val Ala Gly Phe Ala
385 390 395 400 Gly Leu Phe Thr Thr Gly Ala Lys Gln Asn Leu Tyr Leu
Ile Asn Thr 405 410 415 Asn Gly Ser Trp His Ile Asn Arg Thr Ala Leu
Asn Cys Asn Asp Ser 420 425 430 Leu Gln Thr Gly Phe Leu Ala Ser Leu
Phe Tyr Thr His Lys Phe Asn 435 440 445 Ser Ser 450 202 319 PRT
hepatitis C virus MISC_FEATURE (319)..(319) Xaa is any amino acid
202 Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15 Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile
Val Gly 20 25 30 Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu
Gly Val Arg Ala 35 40 45 Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro
Arg Gly Arg Arg Gln Pro 50 55 60 Ile Pro Lys Asp Arg Arg Thr Thr
Gly Lys Ser Trp Gly Arg Pro Gly 65 70 75 80 Tyr Pro Trp Pro Leu Tyr
Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 85 90 95 Leu Leu Ser Pro
Arg Gly Ser Arg Pro Ser Trp Gly Pro Thr Asp Pro 100 105 110 Arg His
Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val 130
135 140 Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu
Asp 145 150 155 160 Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys
Ser Phe Ser Ile 165 170 175 Phe Leu Ser Ala Leu Leu Ser Cys Ile Ser
Val Pro Val Ser Ala Val 180 185 190 Glu Val Lys Asn Thr Ser Thr Ser
Tyr Met Val Thr Asn Asp Cys Ser 195 200 205 Asn Ser Ser Ile Val Trp
Gln Leu Glu Gly Ala Val Leu His Thr Pro 210 215 220 Gly Cys Val Pro
Cys Glu Gln Ile Gly Asn Ala Ser Arg Cys Trp Val 225 230 235 240 Pro
Val Ser Pro Asn Val Ala Ile Arg Gln Pro Gly Thr Leu Thr Lys 245 250
255 Gly Leu Arg Ala His Val Asp Val Ile Val Met Ser Ala Thr Leu Cys
260 265 270 Ser Ala Leu Tyr Val Gly Asp Val Cys Gly Ala Leu Met Ile
Ala Ala 275 280 285 Gln Ala Val Ile Ala Ser Pro Gln Arg His Thr Phe
Val Gln Glu Cys 290 295 300 Asn Cys Ser Ile Tyr Pro Gly His Ile Thr
Gly His Arg Met Xaa 305 310 315 203 193 PRT hepatitis C virus
MISC_FEATURE (5)..(5) Xaa is any amino acid 203 Thr Cys Gly Phe Xaa
Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala 1 5 10 15 Pro Xaa Gly
Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu 20 25 30 Glu
Asp Gly Ile Xaa Tyr Ala Thr Gly Asn Met Pro Gly Cys Ser Phe 35 40
45 Ser Ile Phe Leu Leu Ala Leu Leu Ser Xaa Ile Ser Val Pro Val Ser
50 55 60 Ala Xaa Glu Val Arg Asn Thr Ser Thr Leu Tyr Met Val Thr
Asn Asp 65 70 75 80 Cys Ser Asn Ser Ser Ile Val Trp Gln Leu Glu Gly
Ala Val Xaa His 85 90 95 Ile Pro Gly Cys Val Pro Cys Glu Trp Thr
Asn Thr Thr Pro Arg Cys 100 105 110 Trp Val Pro Val Ser Pro Xaa Val
Ala Ile Arg Gln Pro Gly Ala Leu 115 120 125 Thr Lys Gly Leu Arg Ala
His Ile Asp Val Ile Val Met Ser Ala Thr 130 135 140 Leu Cys Ser Ala
Leu Tyr Val Gly Asp Val Cys Gly Ala Leu Met Ile 145 150 155 160 Ala
Ala Gln Ala Val Val Ala Ser Pro Gln Arg His Xaa Phe Val Gln 165 170
175 Glu Cys Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met
180 185 190 Xaa 204 304 PRT hepatitis C virus 204 Met Ser Thr Asn
Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 1 5 10 15 Arg Arg
Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 35
40 45 Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln
Pro 50 55 60 Ile Pro Lys Asp Arg Arg Pro Thr Gly Lys Ser Trp Gly
Lys Pro Gly 65 70 75 80 Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu
Gly Trp Ala Gly Trp 85 90 95 Leu Leu Ser Pro Arg Gly Ser Arg Pro
Ser Trp Gly Pro Thr Asp Pro 100 105 110 Arg His Arg Ser Arg Asn Leu
Gly Lys Val Ile Asp Thr Leu Thr Cys 115 120 125 Gly Phe Ala Asp Leu
Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val 130 135 140 Gly Gly Val
Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 145 150 155 160
Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 165
170 175 Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr Val Pro Val Ser Gly
Leu 180 185 190 Gln Val Lys Asn Thr Ser Ser Ser Tyr Met Val Thr Asn
Asp Cys Gln 195 200 205 Asn Ser Ser Ile Val Trp Gln Leu Arg Asp Ala
Val Leu His Val Pro 210 215 220 Gly Cys Val Pro Cys Glu Glu Lys Gly
Asn Ile Ser Arg Cys Trp Ile 225 230 235 240 Pro Val Ser Pro Asn Ile
Ala Val Ser Gln Pro Gly Ala Leu Thr Lys 245 250 255 Gly Leu Arg Thr
His Ile Asp Thr Ile Ile Ala Ser Ala Thr Phe Cys 260 265 270 Ser Ala
Leu Tyr Ile Gly Asp Leu Cys Gly Ala Val Met Val Gln Asp 275 280 285
Cys Asn Cys Ser Ile Tyr Pro Gly His Ile Thr Gly His Arg Met Ala 290
295 300 205 277 PRT hepatitis C virus MISC_FEATURE (70)..(70) Xaa
is any amino acid 205 Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr
Lys Arg Asn Thr Asn 1 5 10 15 Arg Arg Pro Gln Asp Val Lys Phe Pro
Gly Gly Gly Gln Ile Val Gly 20 25 30 Gly Val Tyr Leu Leu Pro Arg
Arg Gly Pro Arg Leu Gly Val Arg Ala 35 40 45 Thr Arg Lys Thr Ser
Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 50 55 60 Ile Pro Lys
Asp Arg Xaa Ala Thr Gly Arg Ser Trp Gly Arg Pro Gly 65 70 75 80 Tyr
Pro Trp Pro Leu Tyr Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 85 90
95 Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Leu Ala Xaa Gly
100 105 110 Val Arg Val Leu Glu Asp Gly Ile Asn Tyr Xaa Thr Gly Asn
Leu Pro 115 120 125 Gly Cys Ser Phe Ser Ile Phe Xaa Leu Ala Leu Leu
Ser Cys Val Thr 130 135 140 Val Pro Val Ser Xaa Val Glu Val Lys Asn
Thr Ser Gln Ala Tyr Met 145 150 155 160 Ala Thr Asn Asp Cys Ser Asn
Asn Ser Ile Val Trp Gln Leu Xaa Asp 165 170 175 Ala Val Leu His Val
Pro Gly Cys Val Pro Cys Glu Asn Ser Ser Gly 180 185 190 Arg Phe His
Cys Trp Ile Pro Ile Ser Pro Asn Ile Ala Val Ser Lys 195 200 205 Pro
Gly Ala Leu Thr Lys Gly Leu Arg Ala Arg Ile Asp Ala Val Val 210 215
220 Met Ser Ala Thr Leu Cys Ser Ala Leu Tyr Val Gly Asp Val Cys Gly
225 230 235 240 Ala Val Met Ile Ala Ala Gln Ala Phe Ile Val Ala Pro
Lys Arg His 245 250 255 Tyr Phe Val Gln Glu Cys Asn Cys Ser Ile Tyr
Pro Gly His Ile Thr 260 265 270 Gly His Arg Met Ala 275 206 319 PRT
hepatitis C virus MISC_FEATURE (131)..(131) Xaa is any amino acid
206 Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15 Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile
Val Gly 20 25 30 Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu
Gly Val Arg Ala 35 40 45 Pro Arg Lys Thr Ser Glu Arg Ser Gln Pro
Arg Gly Arg Arg Gln Pro 50 55 60 Ile Pro Lys Asp Arg Arg Ala Thr
Gly Lys Ser Trp Gly Arg Pro Gly 65 70 75 80 Tyr Pro Trp Pro Leu Tyr
Gly Asn Glu Gly Leu Gly Trp Ala Gly Trp 85 90 95 Leu Leu Ser Pro
Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 100 105 110 Arg His
Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 115 120 125
Gly Phe Xaa Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val 130
135 140 Gly Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu
Asp 145 150 155 160 Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys
Ser Phe Ser Ile 165 170 175 Phe Leu Leu Ala Leu Leu Ser Cys Ile Thr
Val Pro Val Ser Ala Ile 180 185 190 Gln Val Lys Asn Asn Ser His Phe
Tyr Met Ala Thr Asn Asp Cys Ala 195 200 205 Asn Asp Ser Ile Val Trp
Gln Leu Arg Asp Ala Val Leu His Val Pro 210 215 220 Gly Cys Val Pro
Cys Glu Arg Ser Gly Asn Arg Thr Phe Cys Trp Thr 225 230 235 240 Ala
Val Ser Pro Asn Val Ala Val Ser Arg Pro Gly Ala Leu Thr Arg 245 250
255 Gly Leu Arg Ala His Ile Asp Thr Ile Val Met Ser Ala Thr Leu Cys
260 265 270 Ser Ala Leu Tyr Ile Gly Asp Leu Cys Gly Ala Val Met Ile
Ala Ala 275 280 285 Gln Val Ala Val Val Ser Pro Gln Tyr His Thr Phe
Val Gln Glu Cys 290 295 300 Asn Cys Ser Ile Tyr Pro Gly His Ile Thr
Gly His Arg Met Xaa 305 310 315 207 187 PRT hepatitis C virus 207
Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro Val Gly Gly Val Ala 1 5
10 15 Arg Ala Leu Ala His Gly Val Arg Ala Leu Glu Asp Gly Ile Asn
Phe 20 25 30 Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile Phe
Leu Leu Ala 35 40 45 Leu Phe Ser Cys Leu Ile His Pro Ala Ala Ser
Leu Glu Trp Arg Asn 50 55 60 Thr Ser Gly Leu Tyr Val Leu Thr Asn
Asp Cys Ser Asn Ser Ser Ile 65 70 75 80 Val Tyr Glu Ala Asp Asp Val
Ile Leu His Thr Pro Gly Cys Val Pro 85 90 95 Cys Val Gln Asp Gly
Asn Thr Ser Ala Cys Trp Thr Pro Val Thr Pro 100 105 110 Thr Val Ala
Val Arg Tyr Val Gly Ala Thr Thr Ala Ser Ile Arg Arg 115 120 125 His
Val Asp Met Leu Val Gly Ala Ala Thr Met Cys Ser Ala Leu Tyr 130 135
140 Val Gly Asp Met Cys Gly Ala Val Phe Leu Val Gly Gln Ala Phe Thr
145 150 155 160 Phe Arg Pro Arg Arg His Gln Thr Val Gln Thr Cys Asn
Cys Ser Leu 165 170 175 Tyr Pro Gly His Leu Ser Gly His Arg Met Ala
180 185 208 187 PRT hepatitis C virus 208 Leu Met Gly Tyr Ile Pro
Leu Val Gly Ala Pro Val Gly Gly Val Ala 1 5 10 15 Arg Ala Leu Ala
His Gly Val Arg Ala Leu Glu Asp Gly Ile Asn Phe 20 25 30 Ala Thr
Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile Phe Leu Leu Ala 35 40 45
Leu Phe Ser Cys Leu Ile His Pro Ala Ala Gly Leu Glu Trp Arg Asn 50
55 60 Thr Ser Gly Leu Tyr Val Leu Thr Asn Asp Cys Ser Asn Ser Ser
Ile 65 70 75 80 Val Tyr Glu Ala Asp Asp Val Ile Leu His Ala Pro Gly
Cys Val Pro 85 90 95 Cys Val Gln Asp Gly Asn Thr Ser Thr Cys Trp
Thr Pro Val Thr Pro 100 105 110 Thr Val Ala Val Arg Tyr Val Gly Ala
Thr Thr Ala Ser Ile Arg Ser 115 120 125 His Val Asp Leu Leu Val Gly
Ala Ala Thr Met Cys Ser Ala Leu Tyr 130 135 140 Val Gly Asp Met Cys
Gly Ala Val Phe Leu Val Gly Gln Ala Phe Thr 145 150 155 160 Phe Arg
Pro Arg Arg His Gln Thr Val Gln Thr Cys Asn Cys Ser Leu 165 170 175
Tyr Pro Gly His Leu Ser Gly His Arg Met Ala 180 185 209 187 PRT
hepatitis C virus 209 Leu Met Gly Tyr Ile Pro Leu Val Gly Ala Pro
Val Gly Gly Val Ala 1 5 10 15 Arg Ala Leu Ala His Gly Val Arg Ala
Leu Glu Asp Gly Ile Asn Phe 20 25 30 Ala Thr Gly Asn Leu Pro Gly
Cys Ser Phe Ser Ile Phe Leu Leu Ala 35 40 45 Leu Phe Ser Cys Leu
Ile His Pro Ala Ala Ser Leu Glu Trp Arg Asn 50 55 60 Thr Ser Gly
Leu Tyr Val Leu Thr Asn Asp Cys Ser Asn Ser Ser Ile 65 70 75 80 Val
Tyr Glu Ala Asp Asp Val Ile Leu His Thr Pro Gly Ile Val Pro 85 90
95 Cys Val Gln Asp Gly Asn Thr Ser Thr Cys Trp Thr Pro Val Thr Pro
100 105 110 Thr Val Ala Val Lys Tyr Val Gly Ala Thr Thr Ala
Ser Ile Arg Ser 115 120 125 His Val Asp Leu Leu Val Gly Ala Ala Thr
Met Cys Ser Ala Leu Tyr 130 135 140 Val Gly Asp Met Cys Gly Ala Val
Phe Leu Val Gly Gln Ala Phe Thr 145 150 155 160 Phe Arg Pro Arg Arg
His Gln Thr Val Gln Thr Cys Asn Cys Ser Leu 165 170 175 Tyr Pro Gly
His Leu Ser Gly His Arg Met Ala 180 185 210 193 PRT hepatitis C
virus 210 Thr Cys Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val
Gly Ala 1 5 10 15 Pro Val Gly Gly Val Ala Arg Ala Leu Ala His Gly
Val Arg Ala Leu 20 25 30 Glu Asp Gly Ile Asn Phe Ala Thr Gly Asn
Leu Pro Gly Cys Ser Phe 35 40 45 Ser Ile Phe Leu Leu Ala Leu Phe
Ser Cys Leu Ile His Pro Ala Ala 50 55 60 Ser Leu Glu Trp Arg Asn
Thr Ser Gly Leu Tyr Val Leu Thr Asn Asp 65 70 75 80 Cys Ser Asn Ser
Ser Ile Val Tyr Glu Ala Asp Asp Val Ile Leu His 85 90 95 Thr Pro
Gly Cys Val Pro Cys Val Gln Asp Gly Asn Thr Ser Thr Cys 100 105 110
Trp Thr Pro Val Thr Pro Thr Val Ala Val Arg Tyr Val Gly Ala Thr 115
120 125 Thr Ala Ser Ile Arg Ser His Val Asp Leu Leu Val Gly Ala Ala
Thr 130 135 140 Met Cys Ser Ala Leu Tyr Val Gly Asp Met Cys Gly Ala
Val Phe Leu 145 150 155 160 Val Gly Gln Ala Phe Thr Phe Arg Pro Arg
Arg His Gln Thr Val Gln 165 170 175 Thr Cys Asn Cys Ser Leu Tyr Pro
Gly His Leu Ser Gly His Arg Met 180 185 190 Ala 211 319 PRT
hepatitis C virus 211 Met Ser Thr Leu Pro Lys Pro Gln Arg Gln Thr
Lys Arg Asn Thr Leu 1 5 10 15 Arg Arg Pro Gln Asn Val Lys Phe Pro
Gly Gly Gly Gln Ile Val Gly 20 25 30 Gly Val Tyr Val Leu Pro Arg
Arg Gly Pro Arg Leu Gly Val Arg Ala 35 40 45 Val Arg Lys Thr Ser
Glu Arg Ser Gln Pro Arg Lys Gln Arg His Leu 50 55 60 Ile Pro Lys
Ala Arg Ser Arg Glu Gly Arg Ser Trp Ala Gln Pro Gly 65 70 75 80 Tyr
Pro Trp Pro Leu Tyr Gly Asn Lys Gly Cys Gly Leu Ala Gly Trp 85 90
95 Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro
100 105 110 Arg Arg Arg Ser Arg Asn Phe Gly Lys Val Ile Asp Thr Leu
Thr Cys 115 120 125 Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Leu Val
Gly Ala Pro Val 130 135 140 Gly Gly Val Ala Arg Ala Leu Ala His Gly
Val Arg Ala Leu Gly Asp 145 150 155 160 Gly Val Asn Tyr Ala Thr Gly
Asn Leu Pro Gly Cys Ser Phe Ser Ile 165 170 175 Phe Leu Leu Ala Leu
Phe Ser Cys Leu Thr Cys Pro Ala Ser Gly Leu 180 185 190 Glu Tyr Thr
Asn Thr Ser Gly Leu Tyr Val Leu Thr Asn Asp Cys Ser 195 200 205 Asn
Gly Ser Ile Val Tyr Glu Ala Glu Asp Val Ile Leu His Leu Pro 210 215
220 Gly Cys Val Pro Cys Val Thr Thr Gly Asn Gln Ser Ser Cys Trp Thr
225 230 235 240 Thr Val Ser Thr Thr Val Ala Val Arg Thr Leu Gly Val
Thr Thr Ala 245 250 255 Ser Ile Arg Thr His Val Asp Met Leu Val Gly
Ala Arg Gln Leu Cys 260 265 270 Ser Ala Leu Tyr Val Gly Asp Ala Phe
Gly Ala Val Phe Leu Val Gly 275 280 285 Gln Ala Phe Thr Phe Arg Pro
Arg Arg His Thr Thr Val Gln Thr Cys 290 295 300 Asn Cys Ser Ile Tyr
Pro Gly His Val Ser Gly His Arg Met Ala 305 310 315 212 193 PRT
hepatitis C virus 212 Thr Cys Gly Phe Ala Asp Leu Met Gly Tyr Ile
Pro Leu Val Gly Ala 1 5 10 15 Pro Val Gly Gly Val Ala Arg Ala Leu
Ala His Gly Val Arg Ala Val 20 25 30 Glu Asp Gly Ile Asn Tyr Ala
Thr Gly Asn Leu Pro Gly Cys Ser Phe 35 40 45 Ser Ile Phe Leu Leu
Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser 50 55 60 Ala Glu His
Tyr Arg Asn Ala Ser Gly Ile Tyr His Ile Thr Asn Asp 65 70 75 80 Cys
Pro Asn Ser Ser Val Val Tyr Glu Thr Asp His His Ile Leu His 85 90
95 Leu Pro Gly Cys Val Pro Cys Val Arg Ala Gly Asn Val Ser Arg Cys
100 105 110 Trp Thr Pro Val Thr Pro Thr Val Ala Ala Val Ser Met Asp
Ala Pro 115 120 125 Leu Glu Ser Phe Arg Arg His Val Asp Leu Met Val
Gly Ala Ala Thr 130 135 140 Val Cys Ser Val Leu Tyr Val Gly Asp Leu
Cys Gly Gly Ala Phe Leu 145 150 155 160 Val Gly Gln Met Phe Thr Phe
Gln Pro Arg Arg His Trp Thr Thr Gln 165 170 175 Asp Cys Asn Cys Ser
Ile Tyr Thr Gly His Ile Thr Gly His Arg Met 180 185 190 Ala 213 193
PRT hepatitis C virus 213 Thr Cys Gly Phe Ala Asp Leu Met Gly Tyr
Ile Pro Leu Val Gly Ala 1 5 10 15 Pro Val Gly Gly Val Ala Arg Ala
Leu Glu His Gly Val Arg Ala Val 20 25 30 Glu Asp Gly Ile Asn Tyr
Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe 35 40 45 Ser Ile Ser Leu
Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Thr Ser 50 55 60 Ala Val
Asn Tyr Arg Asn Ala Ser Gly Val Tyr His Ile Thr Asn Asp 65 70 75 80
Cys Pro Asn Ser Ser Ile Val Tyr Glu Ala Asp Tyr His Ile Leu His 85
90 95 Leu Pro Gly Leu Val Pro Cys Val Arg Val Gly Asn Gln Ser Arg
Cys 100 105 110 Trp Val Ala Leu Thr Pro Thr Val Ala Ala Pro Tyr Val
Gly Ala Pro 115 120 125 Leu Glu Ser Leu Arg Ser His Val Asp Leu Met
Val Gly Ala Ala Thr 130 135 140 Val Cys Ser Ala Leu Tyr Ile Gly Asp
Leu Cys Gly Gly Val Phe Leu 145 150 155 160 Val Gly Gln Met Phe Ser
Phe Gln Pro Arg Arg His Trp Thr Thr Gln 165 170 175 Asp Cys Asn Cys
Ser Ile Tyr Ala Gly His Val Thr Gly His Arg Met 180 185 190 Ala 214
193 PRT hepatitis C virus 214 Thr Cys Gly Phe Ala Asp Leu Met Gly
Tyr Ile Pro Leu Val Gly Ala 1 5 10 15 Pro Val Gly Gly Val Ala Arg
Ala Leu Glu His Gly Val Arg Ala Val 20 25 30 Glu Asp Gly Ile Asn
Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe 35 40 45 Ser Ile Tyr
Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Thr Ser 50 55 60 Ala
Ile His Tyr Arg Asn Ala Ser Gly Val Tyr His Val Thr Asn Asp 65 70
75 80 Cys Pro Asn Ser Ser Ile Val Tyr Glu Ala Asp His His Ile Leu
His 85 90 95 Leu Pro Gly Leu Val Pro Cys Val Arg Val Gly Asn Gln
Ser Arg Cys 100 105 110 Trp Val Ala Leu Ser Pro Thr Val Ala Ala Pro
Tyr Ile Gly Ala Pro 115 120 125 Val Glu Ser Phe Arg Arg His Val Asp
Met Met Val Gly Ala Ala Thr 130 135 140 Val Cys Ser Ala Leu Tyr Ile
Gly Asp Leu Cys Gly Gly Val Phe Leu 145 150 155 160 Val Gly Gln Met
Phe Ser Phe Arg Pro Arg Arg His Trp Thr Thr Gln 165 170 175 Asp Cys
Asn Cys Ser Ile Tyr Ala Gly His Ile Thr Gly His Gly Met 180 185 190
Ala 215 193 PRT hepatitis C virus 215 Thr Cys Gly Phe Ala Asp Leu
Met Gly Tyr Ile Pro Leu Val Gly Ala 1 5 10 15 Pro Val Gly Gly Val
Ala Arg Ala Leu Ala His Gly Val Arg Ala Val 20 25 30 Glu Asp Gly
Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe 35 40 45 Ser
Ile Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Thr Ser 50 55
60 Ala Val Asn Tyr Arg Asn Ala Ser Gly Ile Tyr His Ile Thr Asn Asp
65 70 75 80 Cys Pro Asn Ser Ser Ile Val Tyr Glu Thr Glu His His Ile
Leu His 85 90 95 Leu Pro Gly Leu Val Pro Cys Val Arg Val Gly Asn
Gln Ser Arg Cys 100 105 110 Trp Val Ala Leu Thr Pro Thr Val Ala Ala
Pro Tyr Ile Gly Ala Pro 115 120 125 Leu Glu Ser Leu Arg Ser His Val
Asp Leu Met Val Gly Ala Ala Thr 130 135 140 Ala Cys Ser Ala Leu Tyr
Ile Gly Asp Leu Cys Gly Gly Val Phe Leu 145 150 155 160 Val Gly Gln
Met Phe Ser Phe Gln Pro Arg Arg His Trp Thr Thr Gln 165 170 175 Asp
Cys Asn Cys Ser Ile Tyr Ala Gly His Val Thr Gly His Arg Met 180 185
190 Ala 216 24 PRT hepatitis C virus 216 Thr Cys Gly Phe Ala Asp
Leu Met Gly Tyr Ile Pro Leu Val Gly Ala 1 5 10 15 Pro Val Gly Gly
Val Ala Arg Ala 20 217 319 PRT hepatitis C virus 217 Met Ser Thr
Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 1 5 10 15 Arg
Arg Pro Met Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 20 25
30 Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala
35 40 45 Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg
Gln Pro 50 55 60 Ile Pro Lys Ala Arg Gln Leu Glu Gly Arg Ser Trp
Ala Gln Pro Gly 65 70 75 80 Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly
Cys Gly Trp Ala Gly Trp 85 90 95 Leu Leu Ser Pro Arg Gly Ser Arg
Pro Ser Trp Gly Pro Asn Asp Pro 100 105 110 Arg Arg Arg Ser Arg Asn
Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 115 120 125 Gly Phe Ala Asp
Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Val 130 135 140 Gly Gly
Val Ala Arg Ala Leu Ala His Gly Val Arg Leu Leu Glu Asp 145 150 155
160 Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile
165 170 175 Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser
Ala Tyr 180 185 190 Asn Tyr Arg Asn Ser Ser Gly Val Tyr His Val Thr
Asn Asp Cys Pro 195 200 205 Asn Ser Ser Ile Val Tyr Glu Thr Asp Tyr
His Ile Leu His Leu Pro 210 215 220 Gly Cys Val Pro Cys Val Arg Glu
Gly Asn Lys Ser Thr Cys Trp Val 225 230 235 240 Ser Leu Thr Pro Thr
Val Ala Ala Gln His Leu Asn Ala Pro Leu Glu 245 250 255 Ser Leu Arg
Arg His Val Asp Leu Met Val Gly Gly Ala Thr Leu Cys 260 265 270 Ser
Ala Leu Tyr Ile Gly Asp Val Cys Gly Gly Val Phe Leu Val Gly 275 280
285 Gln Leu Phe Thr Phe Gln Pro Arg Arg His Trp Thr Thr Gln Asp Cys
290 295 300 Asn Cys Ser Ile Tyr Thr Gly His Ile Thr Gly His Arg Met
Ala 305 310 315 218 319 PRT hepatitis C virus MISC_FEATURE
(102)..(102) Xaa is any amino acid 218 Met Ser Thr Asn Pro Lys Pro
Gln Arg Lys Thr Lys Arg Asn Thr Asn 1 5 10 15 Arg Arg Pro Met Asp
Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 20 25 30 Gly Val Tyr
Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 35 40 45 Thr
Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 50 55
60 Ile Pro Lys Ala Arg Arg Thr Glu Gly Arg Ser Trp Ala Gln Pro Gly
65 70 75 80 Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala
Gly Trp 85 90 95 Leu Leu Ser Pro Arg Xaa Ser Arg Xaa Ser Trp Gly
Pro Asn Asp Pro 100 105 110 Arg Xaa Arg Ser Arg Asn Leu Gly Lys Val
Ile Asp Thr Leu Thr Cys 115 120 125 Gly Phe Ala Asp Leu Met Gly Tyr
Ile Pro Leu Val Gly Ala Pro Val 130 135 140 Gly Gly Val Ala Arg Ala
Leu Ala His Gly Val Arg Ala Val Glu Asp 145 150 155 160 Gly Val Asn
Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 165 170 175 Phe
Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Thr Ser Ala Val 180 185
190 Asn Tyr Arg Asn Ala Ser Gly Ile Tyr His Ile Thr Asn Asp Cys Pro
195 200 205 Asn Ala Ser Ile Val Tyr Glu Thr Glu Asn His Ile Leu His
Leu Pro 210 215 220 Gly Cys Val Pro Cys Val Arg Thr Gly Asn Gln Ser
Arg Cys Trp Val 225 230 235 240 Ala Leu Thr Pro Thr Val Ala Ser Pro
Tyr Ala Gly Ala Pro Leu Glu 245 250 255 Pro Leu Arg Arg His Val Asp
Leu Met Val Gly Ala Ala Thr Met Cys 260 265 270 Ser Ala Leu Tyr Ile
Gly Asp Leu Cys Gly Gly Leu Phe Leu Val Gly 275 280 285 Gln Met Phe
Thr Phe Gln Pro Arg Arg His Trp Thr Thr Gln Asp Cys 290 295 300 Asn
Cys Ser Ile Tyr Thr Gly His Ile Thr Gly His Arg Met Ala 305 310 315
219 319 PRT hepatitis C virus 219 Met Ser Thr Asn Pro Lys Leu Gln
Arg Lys Thr Lys Arg Asn Thr Asn 1 5 10 15 Arg Arg Pro Met Asp Val
Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 20 25 30 Gly Val Tyr Leu
Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 35 40 45 Thr Arg
Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 50 55 60
Ile Pro Lys Ala Arg Arg Ser Glu Gly Arg Ser Trp Ala Gln Pro Gly 65
70 75 80 Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala
Gly Trp 85 90 95 Leu Leu Ser Pro Arg Gly Ser Arg Pro Ser Trp Gly
Pro Asn Asp Pro 100 105 110 Arg Arg Arg Ser Arg Asn Leu Gly Lys Val
Ile Asp Thr Leu Thr Cys 115 120 125 Gly Phe Ala Asp Leu Met Gly Tyr
Ile Pro Leu Val Gly Ala Pro Val 130 135 140 Gly Gly Val Ala Arg Ala
Leu Ala His Gly Val Arg Ala Val Glu Asp 145 150 155 160 Gly Ile Asn
Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 165 170 175 Phe
Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Gly Val 180 185
190 Asn Tyr Arg Asn Ala Ser Gly Val Tyr His Ile Thr Asn Asp Cys Pro
195 200 205 Asn Ala Ser Ile Val Tyr Glu Thr Asp Asn His Ile Leu His
Leu Pro 210 215 220 Gly Cys Val Pro Cys Val Lys Thr Gly Asn Gln Ser
Arg Cys Trp Val 225 230 235 240 Ala Leu Thr Pro Thr Val Ala Ser Pro
Tyr Val Gly Ala Pro Leu Glu 245 250 255 Pro Leu Arg Arg His Val Asp
Leu Met Val Gly Ala Ala Thr Val Cys 260 265 270 Ser Ala Leu Tyr Val
Gly Asp Leu Cys Gly Gly Leu Phe Leu Val Gly 275 280 285 Gln Met Phe
Thr Phe Gln Pro Arg Arg His Trp Thr Thr Gln Asp Cys 290 295 300 Asn
Cys Ser Ile Tyr Ala Gly His Ile Thr Gly His Arg Met Ala 305 310 315
220 193 PRT hepatitis C virus 220 Thr Cys Gly Phe Ala Asp Leu Met
Gly Tyr Ile Pro Leu Val Gly Ala 1 5 10 15 Pro Val Gly Gly Val Ala
Arg Ala Leu Ala His Gly Val Arg Ala Val 20 25 30 Glu Asp Gly Ile
Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe 35 40 45 Ser Ile
Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser 50 55 60
Ala Val His Tyr His Asn Thr Ser Gly Ile Tyr His Leu Thr Asn Asp
65 70 75 80 Cys Pro Asn Ser Ser Ile Val Phe Glu Ala Val His His Ile
Leu His 85 90 95 Leu Pro Gly Cys Val Pro Cys Val Arg Thr Gly Asn
Gln Ser Arg Cys 100 105 110 Trp Val Ala Leu Thr Pro Thr Leu Ala Ala
Pro Tyr Leu Gly Ala Pro 115 120 125 Leu Glu Ser Met Arg Arg His Val
Asp Leu Met Val Gly Thr Ala Thr 130 135 140 Leu Cys Ser Ala Leu Tyr
Val Gly Asp Leu Cys Gly Gly Ile Phe Leu 145 150 155 160 Ala Gly Gln
Met Phe Thr Phe Arg Pro Arg Leu His Trp Thr Thr Gln 165 170 175 Glu
Cys Asn Cys Ser Thr Tyr Pro Gly His Ile Thr Gly His Arg Met 180 185
190 Ala 221 193 PRT hepatitis C virus 221 Thr Cys Gly Phe Ala Asp
Leu Met Gly Tyr Ile Pro Leu Val Gly Ala 1 5 10 15 Pro Val Gly Gly
Val Ala Arg Ala Leu Ala His Gly Val Arg Ala Val 20 25 30 Glu Asp
Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe 35 40 45
Ser Ile Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser 50
55 60 Ala Gln His Tyr Arg Asn Ile Ser Gly Ile Tyr His Val Thr Asn
Asp 65 70 75 80 Cys Pro Asn Ser Ser Ile Val Tyr Glu Ala Asp His His
Ile Met His 85 90 95 Leu Pro Gly Cys Val Pro Cys Val Arg Thr Gly
Asn Thr Ser Arg Cys 100 105 110 Trp Val Pro Leu Thr Pro Thr Val Ala
Ala Pro Tyr Val Gly Ala Pro 115 120 125 Leu Glu Ser Met Arg Arg His
Val Asp Leu Met Val Gly Ala Ala Thr 130 135 140 Val Cys Ser Ala Leu
Tyr Ile Gly Asp Leu Cys Gly Gly Val Phe Leu 145 150 155 160 Val Gly
Gln Met Phe Thr Phe Arg Pro Arg Arg His Trp Thr Thr Gln 165 170 175
Asp Cys Asn Cys Ser Ile Tyr Asp Gly His Ile Thr Gly His Arg Met 180
185 190 Ala 222 193 PRT hepatitis C virus 222 Thr Cys Gly Phe Ala
Asp Leu Met Gly Tyr Ile Pro Leu Val Gly Ala 1 5 10 15 Pro Val Gly
Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Ala Val 20 25 30 Glu
Asp Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe 35 40
45 Ser Ile Phe Leu Leu Val Leu Leu Ser Arg Leu Thr Val Pro Ala Ser
50 55 60 Ala Gln His Tyr Arg Asn Ala Ser Gly Ile Tyr His Val Thr
Asn Asp 65 70 75 80 Cys Pro Asn Ser Ser Ile Val Tyr Glu Ala Asp His
His Ile Met His 85 90 95 Leu Pro Gly Cys Val Pro Cys Val Arg Thr
Gly Asn Val Ser Arg Cys 100 105 110 Trp Ile Pro Leu Thr Pro Thr Val
Ala Val Pro Tyr Leu Gly Ala Pro 115 120 125 Leu Thr Ser Val Arg Gln
His Val Asp Leu Met Val Gly Ala Ala Thr 130 135 140 Leu Cys Ser Ala
Leu Tyr Ile Gly Asp His Cys Gly Gly Val Phe Leu 145 150 155 160 Ala
Gly Gln Met Val Ser Phe Gln Pro Arg Arg His Trp Thr Thr Gln 165 170
175 Asp Cys Asn Cys Ser Ile Tyr Val Gly His Ile Thr Gly His Arg Met
180 185 190 Ala 223 193 PRT hepatitis C virus MISC_FEATURE
(24)..(24) Xaa is any amino acid 223 Thr Cys Gly Phe Ala Asp Leu
Met Gly Tyr Ile Pro Leu Val Gly Ala 1 5 10 15 Pro Val Gly Gly Val
Ala Arg Xaa Leu Ala His Gly Val Arg Ala Leu 20 25 30 Glu Asp Gly
Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe 35 40 45 Ser
Ile Ser Leu Leu Glu Leu Leu Ser Cys Leu Thr Val Pro Ala Ser 50 55
60 Ala Ile His Tyr Arg Asn Ala Ser Asp Gly Tyr Tyr Ile Thr Asn Asp
65 70 75 80 Cys Pro Asn Ser Ser Ile Val Tyr Glu Ala Glu Asn His Ile
Leu His 85 90 95 Leu Pro Gly Ile Val Pro Cys Val Lys Thr Gly Asn
Gln Ser Arg Cys 100 105 110 Trp Val Ala Leu Thr Pro Thr Leu Ala Ala
Pro His Leu Arg Ala Pro 115 120 125 Leu Ser Ser Leu Arg Ala His Val
Asp Leu Met Val Gly Ala Ala Thr 130 135 140 Ala Cys Ser Ala Phe Tyr
Ile Gly Asp Leu Cys Gly Gly Val Phe Leu 145 150 155 160 Ala Gly Gln
Leu Phe Thr Ile Arg Pro Arg Ile His Glu Thr Thr Gln 165 170 175 Asp
Cys Asn Cys Ser Ile Tyr Ser Gly His Ile Thr Gly Xaa Xaa Xaa 180 185
190 Xaa 224 193 PRT hepatitis C virus MISC_FEATURE (51)..(51) Xaa
is any amino acid 224 Ala Cys Gly Phe Ala Asp Leu Met Gly Tyr Ile
Pro Leu Val Gly Ala 1 5 10 15 Pro Val Gly Gly Val Ala Arg Ala Leu
Ala His Gly Val Arg Ala Val 20 25 30 Glu Asp Gly Ile Asn Tyr Ala
Thr Gly Asn Leu Pro Gly Cys Ser Phe 35 40 45 Ser Ile Xaa Leu Leu
Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser 50 55 60 Ala Gln His
Tyr Arg Asn Val Ser Gly Ile Tyr His Val Thr Asn Asp 65 70 75 80 Cys
Pro Asn Ser Ser Ile Val Tyr Glu Ala Asp His His Ile Met His 85 90
95 Leu Pro Gly Ile Val Pro Cys Val Arg Thr Gly Asn Val Ser Arg Cys
100 105 110 Trp Val Ser Leu Thr Pro Thr Val Ala Ala Pro Tyr Leu Gly
Ala Pro 115 120 125 Leu Thr Ser Leu Arg Arg His Val Asp Leu Met Val
Gly Ala Ala Thr 130 135 140 Leu Cys Ser Ala Leu Tyr Val Gly Asp Leu
Cys Gly Gly Val Phe Leu 145 150 155 160 Val Gly Gln Met Phe Thr Phe
Gln Pro Arg Arg His Trp Thr Thr Gln 165 170 175 Asp Cys Asn Cys Ser
Ile Tyr Val Gly His Ile Thr Gly His Arg Met 180 185 190 Ala 225 117
PRT hepatitis C virus MISC_FEATURE (95)..(95) Xaa is any amino acid
225 Met Ser Thr Asn Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15 Arg Arg Pro Met Asp Val Lys Phe Pro Gly Gly Gly Gln Ile
Val Gly 20 25 30 Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu
Gly Val Arg Ala 35 40 45 Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro
Arg Gly Arg Arg Gln Pro 50 55 60 Ile Pro Lys Ala Arg Arg Ser Glu
Gly Arg Ser Trp Ala Gln Pro Gly 65 70 75 80 Tyr Pro Trp Pro Leu Tyr
Gly Asn Glu Gly Cys Gly Trp Ala Xaa Trp 85 90 95 Leu Leu Ser Pro
Arg Gly Ser Arg Pro Ser Trp Gly Pro Asn Asp Pro 100 105 110 Arg Arg
Arg Ser Arg 115 226 319 PRT hepatitis C virus 226 Met Ser Thr Asn
Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 1 5 10 15 Arg Arg
Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Met Gly Val Arg Ala 35
40 45 Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln
Pro 50 55 60 Ile Pro Lys Ala Arg Gln Pro Thr Gly Arg Ser Trp Gly
Gln Pro Gly 65 70 75 80 Tyr Pro Trp Pro Leu Tyr Ala Asn Glu Gly Leu
Gly Trp Ala Gly Trp 85 90 95 Leu Leu Ser Pro Arg Gly Ser Arg Pro
Asn Trp Gly Pro Asn Asp Pro 100 105 110 Arg Arg Lys Ser Arg Asn Leu
Gly Lys Val Ile Asp Thr Leu Thr Cys 115 120 125 Gly Phe Ala Asp Leu
Met Gly Tyr Ile Pro Leu Val Gly Gly Pro Ile 130 135 140 Gly Gly Val
Ala Arg Ala Leu Ala His Gly Val Arg Val Leu Glu Asp 145 150 155 160
Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 165
170 175 Phe Ile Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala
Val 180 185 190 Pro Tyr Arg Asn Ala Ser Gly Ile Tyr His Val Thr Asn
Asp Cys Pro 195 200 205 Asn Ser Ser Ile Val Tyr Glu Ala Asp Asn Leu
Ile Leu His Ala Pro 210 215 220 Gly Cys Val Pro Cys Val Met Thr Gly
Asn Val Ser Arg Cys Trp Val 225 230 235 240 Gln Ile Thr Pro Thr Leu
Ser Ala Pro Ser Leu Gly Ala Val Thr Ala 245 250 255 Pro Leu Arg Arg
Ala Val Asp Tyr Leu Ala Gly Gly Ala Ala Leu Cys 260 265 270 Ser Ala
Leu Tyr Val Gly Asp Ala Cys Gly Ala Leu Phe Leu Val Gly 275 280 285
Gln Met Phe Thr Tyr Arg Pro Arg Gln His Ala Thr Val Gln Asn Cys 290
295 300 Asn Cys Ser Ile Tyr Ser Gly His Val Thr Gly His Arg Met Ala
305 310 315 227 193 PRT hepatitis C virus 227 Thr Cys Gly Phe Ala
Asp Leu Val Gly Tyr Ile Pro Leu Val Gly Gly 1 5 10 15 Pro Val Gly
Gly Val Ala Arg Ala Leu Ala His Gly Val Arg Val Leu 20 25 30 Glu
Asp Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe 35 40
45 Ser Ile Phe Ile Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser
50 55 60 Ala Val Pro Tyr Arg Asn Ala Ser Gly Ile Tyr His Val Thr
Asn Asp 65 70 75 80 Cys Pro Asn Ser Ser Ile Val Tyr Glu Ala Asp Asp
Leu Ile Leu His 85 90 95 Ala Pro Gly Cys Val Pro Cys Val Arg Lys
Asp Asn Val Ser Arg Cys 100 105 110 Trp Val Gln Ile Thr Pro Thr Leu
Ser Ala Pro Ser Phe Gly Ala Val 115 120 125 Thr Ala Pro Leu Arg Arg
Ala Val Asp Tyr Leu Val Gly Gly Ala Ala 130 135 140 Leu Cys Ser Ala
Leu Tyr Val Gly Asp Ala Cys Gly Ala Leu Phe Leu 145 150 155 160 Val
Gly Gln Met Phe Thr Tyr Arg Pro Arg Gln His Ala Thr Val Gln 165 170
175 Asp Cys Asn Cys Ser Ile Tyr Ser Gly His Val Thr Gly His Gln Met
180 185 190 Ala 228 319 PRT hepatitis C virus 228 Met Ser Thr Leu
Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 1 5 10 15 Arg Arg
Pro Thr Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val Gly 20 25 30
Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 35
40 45 Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln
Pro 50 55 60 Ile Pro Lys Ala Arg Gln Pro Gln Gly Arg His Trp Ala
Gln Pro Gly 65 70 75 80 Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys
Gly Trp Ala Gly Trp 85 90 95 Leu Leu Ser Pro Arg Gly Ser Arg Pro
His Trp Gly Pro Asn Asp Pro 100 105 110 Arg Arg Arg Ser Arg Asn Leu
Gly Lys Val Ile Asp Thr Leu Thr Cys 115 120 125 Gly Phe Ala Asp Leu
Met Gly Tyr Ile Pro Val Val Gly Ala Pro Leu 130 135 140 Gly Gly Val
Ala Ala Ala Leu Ala His Gly Val Arg Ala Ile Glu Asp 145 150 155 160
Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 165
170 175 Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Thr Pro Ala Ser Ala
Leu 180 185 190 Thr Tyr Gly Asn Ser Ser Gly Leu Tyr His Leu Thr Asn
Asp Cys Pro 195 200 205 Asn Ser Ser Ile Val Leu Glu Ala Asp Ala Met
Ile Leu His Leu Pro 210 215 220 Gly Cys Leu Pro Cys Val Arg Val Asp
Asp Arg Ser Thr Cys Trp His 225 230 235 240 Ala Val Thr Pro Thr Leu
Ala Ile Pro Asn Ala Ser Thr Pro Ala Thr 245 250 255 Gly Phe Arg Arg
His Val Asp Leu Leu Ala Gly Ala Ala Val Val Cys 260 265 270 Ser Ser
Leu Tyr Ile Gly Asp Leu Cys Gly Ser Leu Phe Leu Ala Gly 275 280 285
Gln Leu Phe Thr Phe Gln Pro Arg Arg His Trp Thr Val Gln Asp Cys 290
295 300 Asn Cys Ser Ile Tyr Thr Gly His Val Thr Gly His Arg Met Ala
305 310 315 229 319 PRT hepatitis C virus MISC_FEATURE (128)..(129)
Xaa is any amino acid 229 Met Ser Thr Leu Pro Lys Pro Gln Arg Lys
Thr Lys Arg Asn Thr Asn 1 5 10 15 Arg Arg Pro Met Asp Val Lys Phe
Pro Gly Gly Gly Gln Ile Val Gly 20 25 30 Gly Val Tyr Leu Leu Pro
Arg Arg Gly Pro Arg Leu Gly Val Arg Ala 35 40 45 Thr Arg Lys Thr
Ser Glu Arg Ser Gln Pro Arg Gly Arg Arg Gln Pro 50 55 60 Ile Pro
Lys Val Arg Gln Pro Thr Gly Arg Ser Trp Gly Gln Pro Gly 65 70 75 80
Tyr Pro Trp Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 85
90 95 Leu Leu Ser Pro Arg Gly Ser Arg Pro Asn Trp Gly Pro Asn Asp
Pro 100 105 110 Arg Arg Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr
Leu Thr Xaa 115 120 125 Xaa Leu Ala Asp Leu Met Gly Tyr Ile Pro Val
Leu Gly Gly Pro Leu 130 135 140 Gly Gly Val Ala Ala Ala Leu Ala His
Gly Val Arg Ala Ile Glu Asp 145 150 155 160 Gly Val Asn Tyr Ala Thr
Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile 165 170 175 Phe Leu Leu Ala
Leu Leu Ser Cys Leu Thr Thr Pro Ala Ser Ala Ile 180 185 190 Gln Val
Lys Asn Ala Ser Gly Ile Tyr His Leu Thr Asn Asp Cys Ser 195 200 205
Asn Asn Ser Ile Val Phe Glu Ala Glu Thr Met Ile Leu His Leu Pro 210
215 220 Gly Cys Val Pro Cys Ile Lys Ala Gly Asn Glu Ser Arg Cys Trp
Leu 225 230 235 240 Pro Val Ser Pro Thr Leu Ala Val Pro Asn Ser Ser
Val Pro Ile His 245 250 255 Gly Phe Arg Arg His Val Asp Leu Leu Val
Gly Ala Ala Ala Phe Cys 260 265 270 Ser Ala Met Tyr Ile Gly Asp Leu
Cys Gly Ser Ile Ile Leu Val Gly 275 280 285 Gln Leu Phe Thr Phe Arg
Pro Lys Tyr His Gln Val Thr Gln Asp Cys 290 295 300 Asn Cys Ser Xaa
Asn Xaa Gly His Val Thr Gly His Arg Met Ala 305 310 315 230 319 PRT
hepatitis C virus MISC_FEATURE (144)..(144) Xaa is any amino acid
230 Met Ser Thr Leu Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Ile
1 5 10 15 Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile
Val Gly 20 25 30 Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu
Gly Val Arg Ala 35 40 45 Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro
Arg Gly Arg Arg Gln Pro 50 55 60 Ile Pro Lys Val Arg His Gln Thr
Gly Arg Thr Trp Ala Gln Pro Gly 65 70 75 80 Tyr Pro Trp Pro Leu Tyr
Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 85 90 95 Leu Leu Ser Pro
Arg Gly Ser Arg Pro Asn Trp Gly Pro Asn Asp Pro 100 105 110 Arg Arg
Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 115 120 125
Gly Phe Ala Asp Leu Met Gly Tyr Ile Pro Val Val Gly Ala Pro Xaa 130
135 140 Gly Gly Val Ala Xaa Ala Leu Ala His Gly Val Xaa Xaa Ile Glu
Asp 145 150 155 160 Xaa Val Asn Tyr Ala Thr Xaa Asn Leu Pro Xaa Xaa
Ser Xaa Ser Ile 165 170 175 Xaa Leu Leu Ala Leu Leu Ser Cys Leu Thr
Thr Pro Ala Ser Ala Ala 180 185 190 His Tyr Thr Asn Lys Ser Gly Leu
Tyr His Leu Thr Asn Asp Cys Pro 195 200 205 Asn Ser Ser Ile Val Tyr
Glu Ala Glu Thr Leu Ile Leu His Leu Pro 210
215 220 Gly Cys Val Pro Cys Val Lys Xaa Xaa Asn Gln Ser Arg Cys Trp
Val 225 230 235 240 Gln Ala Ser Pro Thr Leu Ala Val Pro Asn Ala Ser
Thr Pro Val Thr 245 250 255 Gly Phe Arg Lys His Val Asp Ile Met Val
Gly Ala Ala Ala Phe Cys 260 265 270 Ser Ala Met Tyr Val Gly Asp Leu
Cys Gly Gly Leu Phe Leu Val Gly 275 280 285 Gln Leu Phe Thr Leu Arg
Pro Arg Met His Gln Val Val Gln Glu Cys 290 295 300 Asn Cys Ser Ile
Tyr Thr Gly His Ile Thr Gly His Arg Met Ala 305 310 315 231 319 PRT
hepatitis C virus MISC_FEATURE (108)..(108) Xaa is any amino acid
231 Met Ser Thr Leu Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn
1 5 10 15 Arg Arg Pro Met Asp Val Lys Phe Pro Gly Gly Gly Gln Ile
Val Gly 20 25 30 Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu
Gly Val Arg Ala 35 40 45 Thr Arg Lys Thr Ser Glu Arg Ser Gln Ala
Arg Gly Arg Arg Gln Pro 50 55 60 Ile Pro Lys Val Arg Gln Asn Gln
Gly Arg Thr Trp Ala Gln Pro Gly 65 70 75 80 Tyr Pro Trp Pro Leu Tyr
Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 85 90 95 Leu Leu Ser Pro
Arg Gly Ser Arg Pro Asp Trp Xaa Pro Asn Asp Pro 100 105 110 Arg Xaa
Arg Ser Arg Asn Leu Gly Lys Val Ile Asp Thr Leu Thr Cys 115 120 125
Gly Phe Ala Asp Leu Met Glu Tyr Ile Pro Val Val Gly Ala Pro Leu 130
135 140 Gly Gly Val Ala Ala Glu Leu Xaa His Gly Val Arg Ala Ile Glu
Asp 145 150 155 160 Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys
Ser Phe Ser Ile 165 170 175 Phe Xaa Leu Ala Leu Leu Ser Cys Leu Thr
Thr Pro Ala Ser Ala Leu 180 185 190 Asn Tyr Ala Asn Lys Ser Gly Leu
Tyr His Leu Thr Asn Asp Cys Pro 195 200 205 Asn Ser Ser Ile Val Tyr
Glu Ala Asn Gly Met Ile Leu His Leu Pro 210 215 220 Gly Cys Val Pro
Cys Val Lys Thr Gly Asn Leu Thr Lys Cys Trp Leu 225 230 235 240 Ser
Ala Ser Pro Thr Leu Ala Val Gln Asn Ala Ser Val Ser Ile Arg 245 250
255 Gly Val Arg Glu His Val Asp Leu Leu Val Gly Ala Ala Ala Phe Cys
260 265 270 Ser Ala Met Tyr Val Gly Asp Leu Cys Gly Gly Leu Phe Leu
Val Gly 275 280 285 Gln Leu Phe Thr Phe Arg Pro Arg Met Tyr Glu Ile
Ala Gln Asp Cys 290 295 300 Asn Cys Ser Ile Tyr Ala Gly His Ile Thr
Gly His Arg Met Ala 305 310 315 232 100 PRT hepatitis C virus 232
Met Ser Thr Leu Pro Lys Pro Gln Arg Lys Thr Lys Arg Asn Thr Asn 1 5
10 15 Arg Arg Pro Gln Asp Val Lys Phe Pro Gly Gly Gly Gln Ile Val
Gly 20 25 30 Gly Val Tyr Leu Leu Pro Arg Arg Gly Pro Arg Leu Gly
Val Arg Ala 35 40 45 Thr Arg Lys Thr Ser Glu Arg Ser Gln Pro Arg
Gly Arg Arg Gln Pro 50 55 60 Ile Pro Lys Val Arg His Gln Thr Gly
Arg Thr Trp Ala Gln Pro Gly 65 70 75 80 Tyr Pro Trp Pro Leu Tyr Gly
Asn Glu Gly Cys Gly Trp Ala Gly Trp 85 90 95 Leu Leu Ser Pro 100
233 100 PRT hepatitis C virus MISC_FEATURE (17)..(17) Xaa is any
amino acid 233 Met Ser Thr Leu Pro Lys Pro Gln Arg Lys Thr Lys Arg
Asn Thr Asn 1 5 10 15 Xaa Arg Pro Gln Asp Val Lys Phe Pro Gly Gly
Gly Gln Ile Val Gly 20 25 30 Gly Val Tyr Val Leu Pro Arg Arg Gly
Pro Gln Leu Gly Val Arg Ala 35 40 45 Val Arg Lys Thr Ser Glu Arg
Ser Gln Pro Arg Ser Arg Arg Gln Pro 50 55 60 Ile Pro Arg Ala Arg
Arg Thr Glu Gly Arg Ser Trp Ala Gln Pro Gly 65 70 75 80 Tyr Pro Trp
Pro Leu Tyr Gly Asn Glu Gly Cys Gly Trp Ala Gly Trp 85 90 95 Leu
Leu Ser Pro 100 234 128 PRT hepatitis C virus 234 Val Glu Val Lys
Asp Thr Gly Asp Ser Tyr Met Pro Thr Asn Asp Cys 1 5 10 15 Ser Asn
Ser Ser Ile Val Trp Gln Leu Glu Gly Ala Val Leu His Thr 20 25 30
Pro Gly Cys Val Pro Cys Glu Arg Thr Ala Asn Val Ser Arg Cys Trp 35
40 45 Val Pro Val Ala Pro Asn Leu Ala Ile Ser Gln Pro Gly Ala Leu
Thr 50 55 60 Lys Gly Leu Arg Ala His Ile Asp Ile Ile Val Met Ser
Ala Thr Val 65 70 75 80 Cys Ser Ala Leu Tyr Val Gly Asp Val Cys Gly
Ala Leu Met Leu Ala 85 90 95 Ala Gln Val Val Val Val Ser Pro Gln
His His Thr Phe Val Gln Glu 100 105 110 Cys Asn Cys Ser Ile Tyr Pro
Gly Arg Ile Thr Gly His Arg Met Ala 115 120 125 235 149 PRT
hepatitis C virus 235 Asp Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro
Gly Cys Ser Phe Ser 1 5 10 15 Ile Phe Leu Leu Ala Leu Leu Ser Cys
Val Thr Val Pro Val Ser Ala 20 25 30 Val Gln Val Lys Asn Thr Ser
Thr Met Tyr Met Ala Thr Asn Asp Cys 35 40 45 Ser Asn Asn Ser Ile
Ile Trp Gln Met Gln Gly Ala Val Leu His Val 50 55 60 Pro Gly Cys
Val Pro Cys Glu Leu Gln Gly Asn Lys Ser Arg Cys Trp 65 70 75 80 Ile
Pro Val Thr Pro Asn Val Ala Val Asn Gln Pro Gly Ala Leu Thr 85 90
95 Arg Gly Leu Arg Thr His Ile Asp Thr Ile Val Met Val Ala Thr Leu
100 105 110 Cys Ser Ala Leu Tyr Ile Gly Asp Val Cys Gly Ala Val Met
Ile Ala 115 120 125 Ala Gln Val Val Ile Val Ser Pro Gln His His Asn
Phe Ser Gln Asp 130 135 140 Cys Asn Cys Ser Ile 145 236 154 PRT
hepatitis C virus 236 Asp Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro
Gly Cys Ser Phe Ser 1 5 10 15 Ile Phe Leu Leu Ala Leu Leu Ser Cys
Leu Thr Val Pro Ala Ser Ala 20 25 30 Val Gln Val Lys Asn Thr Ser
His Ser Tyr Met Val Thr Asn Asp Cys 35 40 45 Ser Asn Ser Ser Ile
Val Trp Gln Leu Lys Asp Ala Val Leu His Val 50 55 60 Pro Gly Cys
Val Pro Cys Glu Arg His Gln Asn Gln Ser Arg Cys Trp 65 70 75 80 Ile
Pro Val Thr Pro Asn Val Ala Val Ser Gln Pro Gly Ala Leu Thr 85 90
95 Arg Gly Leu Arg Thr His Ile Asp Thr Ile Val Ala Ser Ala Thr Val
100 105 110 Cys Ser Ala Leu Tyr Val Gly Asp Phe Cys Gly Ala Val Met
Leu Val 115 120 125 Ser Gln Phe Phe Met Ile Ser Pro Gln His His Ile
Phe Val Gln Asp 130 135 140 Cys Asn Cys Ser Ile Tyr Pro Gly His Ile
145 150 237 118 PRT hepatitis C virus MISC_FEATURE (95)..(95) Xaa
is any amino acid 237 Asp Gly Ile Asn Tyr Ala Thr Gly Asn Leu Pro
Gly Cys Ser Phe Ser 1 5 10 15 Ile Phe Leu Leu Ala Leu Leu Ser Cys
Ile Thr Val Pro Val Ser Ala 20 25 30 Val Gln Val Ala Asn Arg Ser
Gly Ser Tyr Met Val Thr Asn Asp Cys 35 40 45 Ser Asn Ser Ser Ile
Val Trp Gln Leu Glu Glu Ala Val Leu His Val 50 55 60 Pro Gly Cys
Val Pro Cys Glu Trp Lys Asp Asn Thr Ser Arg Cys Trp 65 70 75 80 Ile
Pro Val Thr Pro Asn Ile Ala Val Ser Gln Pro Gly Ala Xaa Thr 85 90
95 Lys Gly Leu Arg Thr His Ile Asp Ile Ile Val Ala Ser Ala Thr Phe
100 105 110 Cys Ser Ala Leu Tyr Val 115 238 128 PRT hepatitis C
virus 238 Glu His Tyr Arg Asn Ala Ser Gly Ile Tyr His Ile Thr Asn
Asp Cys 1 5 10 15 Pro Asn Ser Ser Ile Val Tyr Glu Ala Asp His His
Ile Leu His Leu 20 25 30 Pro Gly Cys Val Pro Cys Val Met Thr Gly
Asn Thr Ser Arg Cys Trp 35 40 45 Thr Pro Val Thr Pro Thr Val Ala
Val Ala His Pro Gly Ala Pro Leu 50 55 60 Glu Ser Phe Arg Arg His
Val Asp Leu Met Val Gly Ala Ala Thr Leu 65 70 75 80 Cys Ser Ala Leu
Tyr Val Gly Asp Leu Cys Gly Gly Ala Phe Leu Met 85 90 95 Gly Gln
Met Ile Thr Phe Arg Pro Arg Arg His Trp Thr Thr Gln Glu 100 105 110
Cys Asn Cys Ser Ile Tyr Thr Gly His Ile Thr Gly His Arg Met Ala 115
120 125 239 128 PRT hepatitis C virus 239 Val His Tyr Arg Asn Ala
Ser Gly Val Tyr His Val Thr Asn Asp Cys 1 5 10 15 Pro Asn Thr Ser
Ile Val Tyr Glu Thr Glu His His Ile Met His Leu 20 25 30 Pro Gly
Cys Val Pro Cys Val Arg Thr Glu Asn Thr Ser Arg Cys Trp 35 40 45
Val Pro Leu Thr Pro Thr Val Ala Ala Pro Tyr Pro Asn Ala Pro Leu 50
55 60 Glu Ser Met Arg Arg His Val Asp Leu Met Val Gly Ala Ala Thr
Met 65 70 75 80 Cys Ser Ala Phe Tyr Ile Gly Asp Leu Cys Gly Gly Val
Phe Leu Val 85 90 95 Gly Gln Leu Phe Asp Phe Arg Pro Arg Arg His
Trp Thr Thr Gln Asp 100 105 110 Cys Asn Cys Ser Ile Tyr Pro Gly His
Val Ser Gly His Arg Met Ala 115 120 125 240 128 PRT hepatitis C
virus 240 Val Asn Tyr Arg Asn Ala Ser Gly Val Tyr His Val Thr Asn
Asp Cys 1 5 10 15 Pro Asn Ser Ser Ile Val Tyr Glu Ala Glu His Gln
Ile Leu His Leu 20 25 30 Pro Gly Leu Val Pro Cys Val Arg Val Gly
Asn Gln Ser Arg Cys Trp 35 40 45 Val Ala Leu Thr Pro Thr Val Ala
Val Ser Tyr Ile Gly Ala Pro Leu 50 55 60 Asp Ser Leu Arg Arg His
Val Asp Leu Met Val Gly Ala Ala Thr Val 65 70 75 80 Cys Ser Ala Leu
Tyr Val Gly Asp Leu Cys Gly Gly Ala Phe Leu Val 85 90 95 Gly Gln
Met Phe Ser Phe Gln Pro Arg Arg His Trp Thr Thr Gln Asp 100 105 110
Cys Asn Cys Ser Ile Tyr Ala Gly His Ile Thr Gly His Arg Met Ala 115
120 125 241 128 PRT hepatitis C virus 241 Val Asn Tyr His Asn Ala
Ser Gly Val Tyr His Ile Thr Asn Asp Cys 1 5 10 15 Pro Asn Ser Ser
Ile Met Tyr Glu Ala Glu His His Ile Leu His Leu 20 25 30 Pro Gly
Cys Val Pro Cys Val Arg Glu Gly Asn Gln Ser Arg Cys Trp 35 40 45
Val Ala Leu Thr Pro Thr Val Ala Ala Pro Tyr Ile Gly Ala Pro Leu 50
55 60 Glu Ser Ile Arg Arg His Val Asp Leu Met Val Gly Ala Ala Thr
Val 65 70 75 80 Cys Ser Ala Leu Tyr Ile Gly Asp Leu Cys Gly Gly Val
Phe Leu Val 85 90 95 Gly Gln Met Phe Ser Phe Gln Pro Arg Arg His
Trp Thr Thr Gln Asp 100 105 110 Cys Asn Cys Ser Ile Tyr Ala Gly His
Val Thr Gly His Arg Met Ala 115 120 125 242 169 PRT hepatitis C
virus 242 Leu Ala His Gly Val Arg Ala Val Glu Asp Gly Ile Asn Tyr
Ala Thr 1 5 10 15 Gly Asn Leu Pro Gly Cys Ser Phe Ser Ile Phe Leu
Leu Ala Leu Leu 20 25 30 Ser Cys Leu Thr Val Pro Ala Ser Ala Val
His Tyr His Asn Thr Ser 35 40 45 Gly Ile Tyr His Ile Thr Asn Asp
Cys Pro Asn Ser Ser Ile Val Phe 50 55 60 Glu Ala Glu His His Ile
Leu His Leu Pro Gly Cys Val Pro Cys Val 65 70 75 80 Arg Thr Gly Asn
Gln Ser Arg Cys Trp Ile Ala Leu Thr Pro Thr Leu 85 90 95 Ala Ala
Pro His Ile Gly Ala Pro Leu Glu Ser Met Arg Arg His Val 100 105 110
Asp Leu Met Val Gly Thr Ala Thr Leu Cys Ser Ala Leu Tyr Ile Gly 115
120 125 Asp Leu Cys Gly Gly Ile Phe Leu Val Gly Gln Met Phe Asn Phe
Arg 130 135 140 Pro Arg Leu His Trp Thr Thr Gln Glu Cys Asn Cys Ser
Ile Tyr Pro 145 150 155 160 Gly His Ile Thr Gly His Arg Met Ala 165
243 149 PRT hepatitis C virus 243 Asp Gly Ile Asn Tyr Ala Thr Gly
Asn Leu Pro Gly Cys Ser Phe Ser 1 5 10 15 Ile Phe Leu Leu Ala Leu
Leu Ser Cys Leu Thr Val Pro Ala Ser Ala 20 25 30 Ile Asn Tyr Arg
Asn Thr Ser Gly Ile Tyr His Val Thr Asn Asp Cys 35 40 45 Pro Asn
Ser Ser Ile Val Tyr Glu Ala Asp His His Ile Leu His Leu 50 55 60
Pro Gly Cys Val Pro Cys Val Arg Thr Gly Asn Gln Ser Arg Cys Trp 65
70 75 80 Val Ala Leu Thr Pro Thr Val Ala Ala Pro Tyr Ile Gly Ala
Pro Leu 85 90 95 Glu Ser Leu Arg Ser His Val Asp Leu Met Val Gly
Ala Ala Thr Val 100 105 110 Cys Ser Ala Leu Tyr Ile Gly Asp Leu Cys
Gly Gly Leu Phe Leu Val 115 120 125 Gly Gln Met Phe Ser Phe Arg Pro
Arg Arg His Trp Thr Ala Gln Asp 130 135 140 Cys Asn Cys Ser Ile 145
244 149 PRT hepatitis C virus 244 Asp Gly Ile Asn Tyr Ala Thr Gly
Asn Leu Pro Gly Cys Ser Phe Ser 1 5 10 15 Ile Phe Leu Leu Ala Leu
Leu Ser Cys Leu Thr Val Pro Ala Ser Ala 20 25 30 Ile Asn Tyr His
Asn Thr Ser Gly Ile Tyr His Ile Thr Asn Asp Cys 35 40 45 Pro Asn
Ser Ser Ile Val Tyr Glu Ala Asp His His Ile Leu His Leu 50 55 60
Pro Gly Cys Val Pro Cys Val Arg Val Gly Asn Gln Ser Ser Cys Trp 65
70 75 80 Val Ala Leu Thr Pro Thr Ile Ala Ala Pro Tyr Ile Gly Ala
Pro Leu 85 90 95 Glu Ser Leu Arg Ser His Val Asp Leu Met Val Gly
Ala Ala Thr Val 100 105 110 Cys Ser Ala Leu Tyr Ile Gly Asp Leu Cys
Gly Gly Ala Phe Leu Val 115 120 125 Gly Gln Met Phe Ser Phe Arg Pro
Arg Arg His Trp Thr Thr Gln Asp 130 135 140 Cys Asn Cys Ser Ile 145
245 149 PRT hepatitis C virus MISC_FEATURE (14)..(14) Xaa is any
amino acid 245 Asp Gly Ile Asn Tyr Ala Thr Gly Asn Ile Pro Gly Cys
Xaa Phe Ser 1 5 10 15 Ile Phe Leu Xaa Ala Leu Leu Ser Cys Leu Thr
Val Pro Ala Ser Ala 20 25 30 Thr Asn Tyr Arg Asn Val Ser Gly Ile
Tyr His Val Thr Asn Asp Cys 35 40 45 Pro Asn Ser Ser Ile Val Tyr
Glu Ala Asp His His Ile Leu Ala Leu 50 55 60 Pro Gly Cys Val Pro
Cys Val Arg Val Gly Asn Gln Ser Arg Cys Trp 65 70 75 80 Val Ala Leu
Thr Pro Thr Val Ala Ala Pro Tyr Thr Ala Ala Pro Leu 85 90 95 Glu
Ser Leu Arg Ser His Val Asp Leu Met Val Gly Ala Ala Thr Val 100 105
110 Cys Ser Ala Leu Tyr Ile Gly Xaa Leu Cys Gly Gly Leu Phe Leu Val
115 120 125 Gly Gln Met Phe Ser Xaa Gln Pro Arg Arg His Trp Thr Thr
Gln Asp 130 135 140 Cys Asn Cys Ser Ile 145 246 149 PRT hepatitis C
virus MISC_FEATURE (9)..(9) Xaa is any amino acid 246 Asp Gly Ile
Asn Tyr Ala Thr Gly Xaa Leu Pro Gly Cys Ser Phe Ser 1 5 10 15 Ile
Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala 20 25
30 Thr Asn Tyr Arg Asn Val Ser Gly Ile Tyr His Val Thr Asn Asp Cys
35 40 45 Pro Asn Ser Ser Ile Val Phe Glu Ala Asp His His Ile Leu
His Leu 50 55 60 Pro Gly Cys Val Pro Cys Val Lys Glu Gly Asn His
Ser Arg Cys Trp 65 70
75 80 Val Ala Leu Thr Pro Thr Val Ala Ala Pro Tyr Ile Gly Ala Pro
Leu 85 90 95 Glu Ser Leu Arg Ser His Val Asp Val Met Val Gly Ala
Ala Thr Val 100 105 110 Cys Ser Ala Leu Tyr Ile Gly Asp Leu Cys Gly
Gly Leu Phe Leu Val 115 120 125 Gly Gln Met Phe Ser Phe Arg Pro Arg
Arg His Trp Thr Thr Gln Glu 130 135 140 Cys Asn Cys Ser Ile 145 247
149 PRT hepatitis C virus 247 Asp Gly Ile Asn Tyr Ala Thr Gly Asn
Leu Pro Gly Cys Ser Phe Ser 1 5 10 15 Ile Phe Ile Leu Ala Leu Leu
Ser Cys Leu Thr Val Pro Ala Ser Ala 20 25 30 Gln His Tyr Arg Asn
Val Ser Gly Ile Tyr His Val Thr Asn Asp Cys 35 40 45 Pro Asn Ser
Ser Ile Val Tyr Glu Ser Asp His His Ile Leu His Leu 50 55 60 Pro
Gly Cys Val Pro Cys Val Lys Thr Gly Asn Thr Ser Arg Cys Trp 65 70
75 80 Val Ala Leu Thr Pro Thr Val Ala Ala Pro Ile Leu Ser Ala Pro
Leu 85 90 95 Met Ser Val Arg Arg His Val Asp Leu Met Val Gly Ala
Ala Thr Leu 100 105 110 Ser Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly
Gly Ala Phe Leu Val 115 120 125 Gly Gln Met Phe Thr Phe Gln Pro Arg
Arg His Trp Thr Val Gln Asp 130 135 140 Cys Asn Cys Ser Ile 145 248
119 PRT hepatitis C virus 248 Tyr His Ile Thr Asn Asp Cys Pro Asn
Ser Ser Val Val Tyr Glu Thr 1 5 10 15 Asp His His Ile Leu His Leu
Pro Gly Cys Val Pro Cys Val Arg Thr 20 25 30 Gly Asn Val Ser Arg
Cys Trp Thr Pro Val Thr Pro Thr Val Ala Ala 35 40 45 Val Ser Val
Asp Ala Pro Leu Glu Ser Phe Arg Arg His Val Asp Leu 50 55 60 Met
Val Gly Ala Ala Thr Leu Cys Ser Val Leu Tyr Val Gly Asp Leu 65 70
75 80 Cys Gly Gly Ala Phe Leu Val Gly Gln Met Phe Thr Phe Gln Pro
Arg 85 90 95 Arg His Trp Thr Thr Gln Asp Cys Asn Cys Ser Ile Tyr
Thr Gly His 100 105 110 Ile Thr Gly His Arg Met Ala 115 249 128 PRT
hepatitis C virus 249 Val Pro Tyr Arg Asn Ala Ser Gly Val Tyr His
Val Thr Asn Asp Cys 1 5 10 15 Pro Asn Ser Ser Ile Val Tyr Glu Ala
Asp Asn Leu Ile Leu His Ala 20 25 30 Pro Gly Cys Val Pro Cys Val
Arg Gln Asp Asn Val Ser Lys Cys Trp 35 40 45 Val Gln Ile Thr Pro
Thr Leu Ser Ala Pro Asn Leu Gly Ala Val Thr 50 55 60 Ala Pro Leu
Arg Arg Ala Val Asp Tyr Leu Ala Gly Gly Ala Ala Leu 65 70 75 80 Cys
Ser Ala Leu Tyr Val Gly Asp Ala Cys Gly Ala Val Phe Leu Val 85 90
95 Gly Gln Met Phe Thr Tyr Arg Pro Arg Gln His Thr Thr Val Gln Asp
100 105 110 Cys Asn Cys Ser Ile Tyr Ser Gly His Ile Thr Gly His Arg
Met Ala 115 120 125 250 68 PRT hepatitis C virus 250 Ile Gly Gly
Ala Gly Asn Asn Thr Leu His Cys Pro Thr Asp Cys Phe 1 5 10 15 Arg
Lys His Pro Asp Ala Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp 20 25
30 Ile Thr Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr
35 40 45 Pro Cys Thr Ile Asn Tyr Thr Ile Phe Lys Ile Arg Met Tyr
Val Gly 50 55 60 Gly Val Glu His 65 251 68 PRT hepatitis C virus
251 Ile Gly Gly Val Gly Asn Asn Thr Leu Leu Cys Pro Thr Asp Cys Phe
1 5 10 15 Arg Lys Tyr Pro Glu Ala Thr Tyr Ser Arg Cys Gly Ser Gly
Pro Arg 20 25 30 Ile Thr Pro Arg Cys Met Val Asp Tyr Pro Tyr Arg
Leu Trp His Tyr 35 40 45 Pro Cys Thr Ile Asn Tyr Thr Ile Phe Lys
Val Arg Met Tyr Val Gly 50 55 60 Gly Val Glu His 65 252 68 PRT
hepatitis C virus 252 Ile Gly Gly Gly Gly Asn Asn Thr Leu His Cys
Pro Thr Asp Cys Phe 1 5 10 15 Arg Lys His Pro Glu Ala Thr Tyr Ser
Arg Cys Gly Ser Gly Pro Trp 20 25 30 Ile Thr Pro Arg Cys Leu Val
Asp Tyr Pro Tyr Arg Leu Trp His Tyr 35 40 45 Pro Cys Thr Ile Asn
Tyr Thr Ile Phe Lys Val Arg Met Tyr Val Gly 50 55 60 Gly Val Glu
His 65 253 68 PRT hepatitis C virus 253 Ile Gly Gly Val Gly Asn Asn
Thr Leu Val Cys Pro Thr Asp Cys Phe 1 5 10 15 Arg Lys His Pro Glu
Ala Thr Tyr Thr Lys Cys Gly Ser Gly Pro Trp 20 25 30 Leu Thr Pro
Arg Cys Met Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr 35 40 45 Pro
Cys Thr Val Asn Phe Thr Val Phe Lys Val Arg Met Tyr Val Gly 50 55
60 Gly Val Glu His 65 254 68 PRT hepatitis C virus 254 Ile Gly Gly
Val Gly Asn His Thr Leu Thr Cys Pro Thr Asp Cys Phe 1 5 10 15 Arg
Lys His Pro Glu Ala Thr Tyr Thr Lys Cys Gly Ser Gly Pro Trp 20 25
30 Leu Thr Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr
35 40 45 Pro Cys Thr Phe Asn Phe Ser Ile Phe Lys Val Arg Met Tyr
Val Gly 50 55 60 Gly Val Glu His 65 255 68 PRT hepatitis C virus
255 Ile Gly Gly Val Gly Asn Arg Thr Leu Ile Cys Pro Thr Asp Cys Phe
1 5 10 15 Arg Lys His Pro Glu Ala Thr Tyr Thr Lys Cys Gly Ser Gly
Pro Trp 20 25 30 Leu Thr Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg
Leu Trp His Tyr 35 40 45 Pro Cys Thr Leu Asn Phe Ser Ile Phe Lys
Val Arg Met Tyr Val Gly 50 55 60 Gly Val Glu His 65 256 68 PRT
hepatitis C virus 256 Ile Gly Gly Val Gly Asn Asn Thr Leu Thr Cys
Pro Thr Asp Cys Phe 1 5 10 15 Arg Lys His Pro Glu Ala Thr Tyr Thr
Arg Cys Gly Ser Gly Pro Trp 20 25 30 Leu Thr Pro Arg Cys Leu Val
Asp Tyr Pro Tyr Arg Leu Trp His Tyr 35 40 45 Pro Cys Thr Val Asn
Phe Ala Ile Phe Lys Val Arg Met Tyr Val Gly 50 55 60 Gly Val Glu
His 65 257 68 PRT hepatitis C virus 257 Ile Gly Gly Val Gly Asn Leu
Thr Leu Thr Cys Pro Thr Asp Cys Phe 1 5 10 15 Arg Lys His Pro Glu
Ala Thr Tyr Thr Lys Cys Gly Ser Gly Pro Trp 20 25 30 Leu Thr Pro
Arg Cys Ile Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr 35 40 45 Pro
Cys Thr Val Asn Phe Thr Ile Phe Lys Val Arg Met Tyr Val Gly 50 55
60 Gly Val Glu His 65 258 68 PRT hepatitis C virus 258 Ile Gly Gly
Val Gly Asn Leu Thr Leu Thr Cys Pro Thr Asp Cys Phe 1 5 10 15 Arg
Lys His Pro Glu Ala Thr Tyr Thr Lys Cys Gly Ser Gly Pro Trp 20 25
30 Leu Thr Pro Arg Cys Ile Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr
35 40 45 Pro Cys Thr Val Asn Phe Thr Ile Phe Lys Val Arg Met Tyr
Val Gly 50 55 60 Gly Val Glu His 65 259 68 PRT hepatitis C virus
259 Ile Gly Gly Val Gly Asn Asn Thr Leu Thr Cys Pro Thr Asp Cys Phe
1 5 10 15 Arg Lys His Pro Glu Ala Thr Tyr Thr Lys Cys Gly Ser Gly
Pro Trp 20 25 30 Leu Thr Pro Arg Cys Met Val Asp Tyr Pro Tyr Arg
Leu Trp His Tyr 35 40 45 Pro Cys Thr Val Asn Phe Thr Ile Phe Lys
Val Arg Met Tyr Val Gly 50 55 60 Gly Val Glu His 65 260 68 PRT
hepatitis C virus 260 Ile Gly Gly Ala Gly Asn Asn Thr Leu Thr Cys
Pro Thr Asp Cys Phe 1 5 10 15 Arg Lys His Pro Glu Ala Thr Tyr Thr
Lys Cys Gly Ser Gly Pro Trp 20 25 30 Leu Thr Pro Arg Cys Met Val
Asp Tyr Pro Tyr Arg Leu Trp His Tyr 35 40 45 Pro Cys Thr Phe Asn
Phe Thr Ile Phe Lys Ile Arg Met Tyr Val Gly 50 55 60 Gly Val Glu
His 65 261 68 PRT hepatitis C virus 261 Ile Gly Gly Gly Gly Asn Asn
Thr Leu Val Cys Pro Thr Asp Cys Phe 1 5 10 15 Arg Lys His Pro Glu
Ala Thr Tyr Thr Lys Cys Gly Ser Gly Pro Trp 20 25 30 Leu Thr Pro
Arg Cys Met Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr 35 40 45 Pro
Cys Thr Val Asn Phe Thr Ile Phe Lys Val Arg Met Tyr Val Gly 50 55
60 Gly Val Glu His 65 262 68 PRT hepatitis C virus 262 Ile Gly Gly
Ser Gly Asn Asn Thr Leu Leu Cys Pro Thr Asp Cys Phe 1 5 10 15 Arg
Lys His Pro Asp Ala Thr Tyr Ser Arg Cys Gly Ser Gly Pro Trp 20 25
30 Leu Thr Pro Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp His Tyr
35 40 45 Pro Cys Thr Val Asn Tyr Thr Ile Phe Lys Ile Arg Met Phe
Val Gly 50 55 60 Gly Val Glu His 65 263 70 PRT hepatitis C virus
263 Ile Arg Ala Asp Phe Asn Ala Ser Met Asp Leu Leu Cys Pro Thr Asp
1 5 10 15 Cys Phe Arg Lys His Pro Asp Thr Thr Tyr Ile Lys Cys Gly
Ser Gly 20 25 30 Pro Trp Leu Thr Pro Arg Cys Leu Ile Asp Tyr Pro
Tyr Arg Leu Trp 35 40 45 His Tyr Pro Cys Thr Val Asn Tyr Thr Ile
Phe Lys Ile Arg Met Tyr 50 55 60 Val Gly Gly Val Glu His 65 70 264
70 PRT hepatitis C virus 264 Ile Arg Lys Asp Tyr Asn Ser Thr Ile
Asp Leu Leu Cys Pro Thr Asp 1 5 10 15 Cys Phe Arg Lys His Pro Asp
Ala Thr Tyr Leu Lys Cys Gly Ala Gly 20 25 30 Pro Trp Leu Thr Pro
Arg Cys Leu Val Asp Tyr Pro Tyr Arg Leu Trp 35 40 45 His Tyr Pro
Cys Thr Val Asn Phe Thr Ile Phe Lys Ala Arg Met Tyr 50 55 60 Val
Gly Gly Val Glu His 65 70 265 278 PRT hepatitis C virus 265 Gly Val
Ala Lys Ala Val Asp Phe Ile Pro Val Glu Asn Leu Glu Thr 1 5 10 15
Thr Met Arg Ser Pro Val Phe Thr Asp Asn Ser Ser Pro Pro Val Val 20
25 30 Pro Gln Ser Phe Gln Val Ala His Leu His Ala Pro Thr Gly Ser
Gly 35 40 45 Lys Ser Thr Lys Val Pro Ala Ala Tyr Ala Ala Gln Gly
Tyr Lys Val 50 55 60 Leu Val Leu Asn Pro Ser Val Ala Ala Thr Leu
Gly Phe Gly Ala Tyr 65 70 75 80 Met Ser Lys Ala His Gly Ile Asp Pro
Asn Ile Arg Thr Gly Val Arg 85 90 95 Thr Ile Thr Thr Gly Ser Pro
Ile Thr Tyr Ser Thr Tyr Gly Lys Phe 100 105 110 Leu Ala Asp Gly Gly
Cys Ser Gly Gly Ala Tyr Asp Ile Ile Ile Cys 115 120 125 Asp Glu Cys
His Ser Thr Asp Ala Thr Ser Ile Leu Gly Ile Gly Thr 130 135 140 Val
Leu Asp Gln Ala Glu Thr Ala Gly Ala Arg Leu Val Val Leu Ala 145 150
155 160 Thr Ala Thr Pro Pro Gly Ser Val Thr Val Pro His Pro Asn Ile
Glu 165 170 175 Glu Val Ala Leu Ser Thr Thr Gly Glu Ile Pro Phe Tyr
Gly Lys Ala 180 185 190 Ile Pro Leu Glu Val Ile Lys Gly Gly Arg His
Leu Ile Phe Cys His 195 200 205 Ser Lys Lys Lys Cys Asp Glu Leu Ala
Ala Lys Leu Val Ala Leu Gly 210 215 220 Ile Asn Ala Val Ala Tyr Tyr
Arg Gly Leu Asp Val Ser Val Ile Pro 225 230 235 240 Thr Ser Gly Asp
Val Val Val Val Ala Thr Asp Ala Leu Met Thr Gly 245 250 255 Tyr Thr
Gly Asp Phe Asp Ser Val Ile Asp Cys Asn Thr Cys Val Thr 260 265 270
Gln Thr Val Asp Phe Ser 275 266 278 PRT hepatitis C virus 266 Gly
Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Asn Leu Glu Thr 1 5 10
15 Thr Met Arg Ser Pro Val Phe Thr Asp Asn Ser Ser Pro Pro Ala Val
20 25 30 Pro Gln Ser Phe Gln Val Ala His Leu His Ala Pro Thr Gly
Ser Gly 35 40 45 Lys Ser Thr Lys Val Pro Ala Ala Tyr Ala Ala Lys
Gly Tyr Lys Val 50 55 60 Leu Val Leu Asn Pro Ser Val Ala Ala Thr
Leu Gly Phe Gly Ala Tyr 65 70 75 80 Met Ser Lys Ala His Gly Val Asp
Pro Asn Ile Arg Thr Gly Val Arg 85 90 95 Thr Ile Thr Thr Gly Ser
Pro Ile Thr Tyr Ser Thr Tyr Gly Lys Phe 100 105 110 Leu Ala Asp Ala
Gly Cys Ser Gly Gly Ala Tyr Asp Ile Ile Ile Cys 115 120 125 Asp Glu
Cys His Ser Thr Asp Ala Thr Ser Ile Ser Gly Ile Gly Thr 130 135 140
Val Leu Asp Gln Ala Glu Thr Ala Gly Ala Arg Leu Val Val Leu Ala 145
150 155 160 Thr Ala Thr Pro Pro Gly Ser Val Thr Val Ser His Pro Asn
Ile Glu 165 170 175 Glu Val Ala Leu Ser Thr Thr Gly Glu Ile Pro Phe
Tyr Gly Lys Ala 180 185 190 Ile Pro Leu Glu Val Ile Lys Gly Gly Arg
His Leu Ile Phe Cys His 195 200 205 Ser Lys Lys Lys Cys Asp Glu Leu
Ala Ala Lys Leu Val Ala Leu Gly 210 215 220 Ile Asn Ala Val Ala Tyr
Tyr Arg Gly Leu Asp Val Ser Val Ile Pro 225 230 235 240 Thr Ser Gly
Asp Val Val Val Val Ser Thr Asp Ala Leu Met Thr Gly 245 250 255 Phe
Thr Gly Asp Phe Asp Ser Val Ile Asp Cys Asn Thr Cys Val Thr 260 265
270 Gln Thr Val Asp Phe Ser 275 267 278 PRT hepatitis C virus 267
Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Leu Glu Thr 1 5
10 15 Thr Met Arg Ser Pro Val Phe Thr Asp Asn Ser Ser Pro Pro Ala
Val 20 25 30 Pro Gln Ser Phe Gln Val Ala His Leu His Ala Pro Thr
Gly Ser Gly 35 40 45 Lys Ser Thr Lys Val Pro Ala Ala Tyr Ala Ala
Gln Gly Tyr Lys Val 50 55 60 Leu Val Leu Asn Pro Ser Val Ala Ala
Thr Leu Gly Phe Gly Ala Tyr 65 70 75 80 Met Ser Lys Ala His Gly Ile
Asp Pro Asn Ile Arg Thr Gly Val Arg 85 90 95 Thr Ile Thr Thr Gly
Ser Pro Ile Thr Tyr Ser Thr Tyr Gly Lys Phe 100 105 110 Leu Ala Asp
Gly Gly Cys Ser Gly Gly Ala Tyr Asp Ile Ile Ile Cys 115 120 125 Asp
Glu Cys His Ser Thr Asp Ala Thr Ser Val Leu Gly Ile Gly Thr 130 135
140 Val Leu Asp Gln Ala Glu Thr Ala Gly Ala Arg Leu Val Val Leu Ala
145 150 155 160 Thr Ala Thr Pro Pro Gly Ser Ile Thr Val Pro His Ala
Asn Ile Glu 165 170 175 Glu Val Ala Leu Ser Thr Thr Gly Glu Ile Pro
Phe Tyr Gly Lys Ala 180 185 190 Ile Pro Leu Glu Ala Ile Lys Gly Gly
Arg His Leu Ile Phe Cys His 195 200 205 Ser Lys Lys Lys Cys Asp Glu
Leu Ala Ala Lys Leu Val Ala Leu Gly 210 215 220 Val Asn Ala Val Ala
Tyr Tyr Arg Gly Leu Asp Val Ser Val Ile Pro 225 230 235 240 Thr Ser
Gly Asp Val Val Val Val Ala Thr Asp Ala Leu Met Thr Gly 245 250 255
Tyr Thr Gly Asp Phe Asp Ser Val Ile Asp Cys Asn Thr Cys Val Thr 260
265 270 Gln Thr Val Asp Phe Ser 275 268 278 PRT hepatitis C virus
268 Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val Glu Ser Met Glu Thr
1 5 10 15 Thr Met Arg Ser Pro Val Phe Thr Asp Asn Ser Ser Pro Pro
Ala Val 20 25 30 Pro Gln Thr Phe Gln Val Ala His Leu His Ala Pro
Thr Gly Ser Gly 35 40 45 Lys Ser Thr Lys Val Pro Ala Ala Tyr Ala
Ala Gln Gly Tyr Lys Val 50 55 60 Leu Val Leu Asn
Pro Ser Val Ala Ala Thr Leu Gly Phe Gly Ala Tyr 65 70 75 80 Met Ser
Lys Ala His Gly Ile Glu Pro Asn Ile Arg Thr Gly Val Arg 85 90 95
Thr Ile Thr Thr Gly Gly Pro Ile Thr Tyr Ser Thr Tyr Cys Lys Phe 100
105 110 Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala Tyr Asp Ile Ile Ile
Cys 115 120 125 Asp Glu Cys His Ser Thr Asp Ser Thr Thr Ile Leu Gly
Ile Gly Thr 130 135 140 Val Leu Asp Gln Ala Glu Thr Ala Gly Ala Arg
Leu Val Val Leu Ala 145 150 155 160 Thr Ala Thr Pro Pro Gly Ser Ile
Thr Val Pro His Pro Asn Ile Glu 165 170 175 Glu Val Ala Leu Ser Asn
Thr Gly Glu Ile Pro Phe Tyr Gly Lys Ala 180 185 190 Ile Pro Ile Glu
Ala Ile Lys Gly Gly Arg His Leu Ile Phe Cys His 195 200 205 Ser Lys
Lys Lys Cys Asp Glu Leu Ala Ala Lys Leu Thr Gly Leu Gly 210 215 220
Leu Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val Ile Pro 225
230 235 240 Thr Ser Gly Asp Val Val Val Val Ala Thr Asp Ala Leu Met
Thr Gly 245 250 255 Phe Thr Gly Asp Phe Asp Ser Val Ile Asp Cys Asn
Thr Cys Val Thr 260 265 270 Gln Thr Val Asp Phe Ser 275 269 278 PRT
hepatitis C virus 269 Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val
Glu Ser Met Glu Thr 1 5 10 15 Thr Met Arg Ser Pro Val Phe Thr Asp
Asn Ser Ser Pro Pro Ala Val 20 25 30 Pro Gln Thr Phe Gln Val Ala
His Leu His Ala Pro Thr Gly Ser Gly 35 40 45 Lys Ser Thr Lys Val
Pro Ala Ala Tyr Ala Ala Gln Gly Tyr Lys Val 50 55 60 Leu Val Leu
Asn Pro Ser Val Ala Ala Thr Leu Gly Phe Gly Ala Tyr 65 70 75 80 Met
Pro Lys Ala His Gly Ile Asp Pro Asn Ile Arg Thr Gly Val Arg 85 90
95 Thr Ile Thr Thr Gly Gly Pro Ile Thr Tyr Ser Thr Tyr Gly Lys Phe
100 105 110 Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala Tyr Asp Ile Ile
Ile Cys 115 120 125 Asp Glu Cys His Ser Thr Asp Ser Thr Thr Ile Leu
Gly Ile Gly Thr 130 135 140 Val Leu Asp Gln Ala Glu Thr Ala Gly Ala
Arg Leu Val Val Leu Ala 145 150 155 160 Thr Ala Thr Pro Pro Gly Ser
Val Thr Val Pro His Pro Asn Ile Glu 165 170 175 Glu Ile Gly Leu Ser
Asn Asn Gly Glu Ile Pro Phe Tyr Gly Lys Ala 180 185 190 Ile Pro Ile
Glu Ala Ile Lys Gly Gly Arg His Leu Ile Phe Cys His 195 200 205 Ser
Lys Lys Lys Cys Asp Glu Leu Ala Ala Lys Leu Thr Gly Leu Gly 210 215
220 Leu Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val Ile Pro
225 230 235 240 Pro Ile Gly Asp Val Ala Val Val Ala Thr Asp Ala Leu
Met Thr Gly 245 250 255 Phe Thr Gly Asp Phe Asp Ser Val Ile Asp Cys
Asn Thr Cys Val Thr 260 265 270 Gln Thr Val Asp Phe Ser 275 270 278
PRT hepatitis C virus 270 Gly Val Ala Lys Ala Val Asp Phe Ile Pro
Val Glu Ser Met Glu Thr 1 5 10 15 Thr Met Arg Ser Pro Val Phe Thr
Asp Asn Ser Ser Pro Pro Ala Val 20 25 30 Pro Gln Thr Phe Gln Val
Ala His Leu His Ala Pro Thr Gly Ser Gly 35 40 45 Lys Ser Thr Lys
Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr Lys Val 50 55 60 Leu Val
Leu Asn Pro Ser Val Ala Ala Thr Leu Gly Phe Gly Ala Tyr 65 70 75 80
Met Ser Lys Ala His Gly Ile Asp Pro Asn Ile Arg Thr Gly Val Arg 85
90 95 Thr Ile Thr Thr Gly Gly Ser Ile Thr Tyr Ser Thr Tyr Gly Lys
Phe 100 105 110 Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala Tyr Asp Ile
Ile Ile Cys 115 120 125 Asp Glu Cys His Ser Thr Asp Ser Thr Thr Ile
Leu Gly Ile Gly Thr 130 135 140 Val Leu Asp Gln Ala Glu Thr Ala Gly
Ala Arg Leu Val Val Leu Ala 145 150 155 160 Thr Ala Thr Pro Pro Gly
Ser Val Thr Val Pro His Pro Asn Ile Glu 165 170 175 Glu Ile Gly Leu
Ser Asn Asn Gly Glu Ile Pro Phe Tyr Gly Lys Ala 180 185 190 Ile Pro
Ile Glu Ala Ile Lys Gly Gly Arg His Leu Ile Phe Cys His 195 200 205
Ser Lys Lys Lys Cys Asp Glu Leu Ala Ala Lys Leu Thr Gly Leu Gly 210
215 220 Leu Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val Ile
Pro 225 230 235 240 Pro Ile Gly Asp Val Val Val Val Ala Thr Asp Ala
Leu Met Thr Gly 245 250 255 Phe Thr Gly Asp Phe Asp Ser Val Ile Asp
Cys Asn Thr Cys Val Thr 260 265 270 Gln Thr Val Asp Phe Ser 275 271
278 PRT hepatitis C virus 271 Gly Val Ala Lys Ala Val Asp Phe Ile
Pro Val Glu Thr Met Glu Thr 1 5 10 15 Thr Met Arg Ser Pro Val Phe
Thr Asp Asn Ser Ser Pro Pro Ala Val 20 25 30 Pro Gln Thr Phe Gln
Val Ala His Leu His Ala Pro Thr Gly Ser Gly 35 40 45 Lys Ser Thr
Lys Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr Lys Val 50 55 60 Leu
Val Leu Asn Pro Ser Val Ala Ala Thr Leu Gly Phe Gly Ala Tyr 65 70
75 80 Met Ser Lys Ala His Gly Val Asp Pro Asn Ile Arg Thr Gly Val
Arg 85 90 95 Thr Ile Thr Thr Gly Ala Pro Ile Thr Tyr Ser Thr Tyr
Gly Lys Phe 100 105 110 Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala Tyr
Asp Ile Ile Ile Cys 115 120 125 Asp Glu Cys His Ser Thr Asp Ser Thr
Thr Ile Leu Gly Ile Gly Thr 130 135 140 Val Leu Asp Gln Ala Glu Thr
Ala Gly Ala Arg Leu Val Val Leu Ala 145 150 155 160 Thr Ala Thr Pro
Pro Gly Ser Val Thr Val Pro His Pro Asn Ile Glu 165 170 175 Glu Val
Ala Leu Ser Asn Thr Gly Glu Ile Pro Phe Tyr Gly Lys Ala 180 185 190
Ile Pro Ile Glu Ala Ile Arg Gly Gly Arg His Leu Ile Phe Cys His 195
200 205 Ser Lys Lys Lys Cys Asp Glu Leu Ala Ala Lys Leu Ser Ser Leu
Gly 210 215 220 Leu Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser
Val Ile Pro 225 230 235 240 Ser Ser Gly Asp Val Val Val Val Ala Thr
Asp Ala Leu Met Thr Gly 245 250 255 Phe Thr Gly Asp Phe Asp Ser Val
Ile Asp Cys Asn Thr Cys Val Thr 260 265 270 Gln Thr Val Asp Phe Ser
275 272 278 PRT hepatitis C virus 272 Gly Val Ala Lys Ala Val Asp
Phe Ile Pro Val Glu Ser Met Glu Thr 1 5 10 15 Thr Met Arg Ser Pro
Val Phe Thr Asp Asn Ser Ser Pro Pro Ala Val 20 25 30 Pro Gln Thr
Phe Gln Val Ala His Leu His Ala Pro Thr Gly Ser Gly 35 40 45 Lys
Ser Thr Lys Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr Lys Val 50 55
60 Leu Val Leu Asn Pro Ser Val Ala Ala Thr Leu Gly Phe Gly Ala Tyr
65 70 75 80 Met Ser Lys Ala His Gly Thr Asp Pro Asn Ile Arg Thr Gly
Val Arg 85 90 95 Thr Ile Thr Thr Gly Ala Pro Ile Thr Tyr Ser Thr
Tyr Gly Lys Phe 100 105 110 Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala
Tyr Asp Ile Ile Ile Cys 115 120 125 Asp Glu Cys His Ser Thr Asp Ser
Thr Thr Ile Leu Gly Ile Gly Thr 130 135 140 Val Leu Asp Gln Ala Glu
Thr Ala Gly Ala Arg Leu Val Val Leu Ala 145 150 155 160 Thr Ala Thr
Pro Pro Gly Ser Val Thr Val Pro His Pro Asn Ile Glu 165 170 175 Glu
Val Ala Leu Ser Asn Thr Gly Glu Ile Pro Phe Tyr Gly Lys Ala 180 185
190 Ile Pro Leu Glu Ala Ile Lys Gly Gly Arg His Leu Ile Phe Cys His
195 200 205 Ser Lys Lys Lys Cys Asp Glu Leu Ala Ala Lys Leu Ser Gly
Leu Gly 210 215 220 Ile Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val
Ser Val Ile Pro 225 230 235 240 Thr Ser Gly Asp Val Val Ile Val Ala
Thr Asp Ala Leu Met Thr Gly 245 250 255 Tyr Thr Gly Asp Phe Asp Ser
Val Ile Asp Cys Asn Thr Cys Val Thr 260 265 270 Gln Thr Val Asp Phe
Ser 275 273 278 PRT hepatitis C virus MISC_FEATURE (60)..(60) Xaa
is any amino acid 273 Gly Val Ala Lys Ala Val Asp Phe Ile Pro Val
Glu Ser Met Glu Thr 1 5 10 15 Thr Met Arg Ser Pro Val Phe Thr Asp
Asn Ser Ser Pro Pro Ala Val 20 25 30 Pro Gln Thr Phe Gln Val Ala
His Leu His Ala Pro Thr Gly Ser Gly 35 40 45 Lys Ser Thr Lys Val
Pro Ala Ala Tyr Ala Ala Xaa Gly Tyr Lys Val 50 55 60 Leu Val Leu
Asn Pro Ser Val Ala Ala Thr Leu Gly Phe Gly Ala Tyr 65 70 75 80 Met
Ser Lys Ala His Gly Thr Asp Pro Asn Ile Arg Thr Gly Val Arg 85 90
95 Thr Ile Thr Thr Gly Gly Pro Ile Thr Tyr Ser Thr Tyr Gly Lys Phe
100 105 110 Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala Tyr Asp Ile Ile
Ile Cys 115 120 125 Asp Glu Cys His Ser Thr Asp Ser Thr Thr Ile Leu
Gly Ile Gly Thr 130 135 140 Val Leu Asp Gln Ala Glu Thr Ala Gly Ala
Arg Leu Val Val Leu Ala 145 150 155 160 Thr Ala Thr Pro Pro Gly Ser
Val Thr Val Pro His Pro Asn Ile Glu 165 170 175 Glu Val Ala Leu Ser
Asn Thr Gly Glu Ile Pro Phe Tyr Gly Lys Ala 180 185 190 Ile Pro Ile
Glu Val Ile Lys Gly Gly Arg His Leu Ile Phe Cys His 195 200 205 Ser
Lys Lys Lys Cys Asp Glu Leu Ala Ala Lys Leu Ser Gly Leu Gly 210 215
220 Ile Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val Ile Pro
225 230 235 240 Thr Ser Gly Asp Val Val Val Val Ala Thr Asp Ala Leu
Met Thr Gly 245 250 255 Tyr Thr Gly Asp Phe Asp Ser Val Ile Asp Cys
Asn Thr Cys Val Thr 260 265 270 Gln Thr Val Asp Phe Ser 275 274 278
PRT hepatitis C virus 274 Gly Val Ala Lys Ala Val Asp Phe Val Pro
Val Glu Ser Met Glu Thr 1 5 10 15 Thr Met Arg Ser Pro Val Phe Thr
Asp Asn Ser Ser Pro Pro Ala Val 20 25 30 Pro Gln Ser Phe Gln Val
Ala His Leu His Ala Pro Thr Gly Ser Gly 35 40 45 Lys Ser Thr Lys
Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr Lys Val 50 55 60 Leu Val
Leu Asn Pro Ser Val Ala Ala Thr Leu Gly Phe Gly Ala Tyr 65 70 75 80
Met Ser Lys Ala His Gly Ile Asp Pro Asn Ile Arg Thr Gly Val Arg 85
90 95 Thr Ile Thr Thr Gly Ala Pro Val Thr Tyr Ser Thr Tyr Gly Lys
Phe 100 105 110 Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala Tyr Asp Ile
Ile Ile Cys 115 120 125 Asp Glu Cys His Ser Thr Asp Ser Thr Thr Ile
Leu Gly Ile Gly Thr 130 135 140 Val Leu Asp Gln Ala Glu Thr Ala Gly
Ala Arg Leu Val Val Leu Ala 145 150 155 160 Thr Ala Thr Pro Pro Gly
Ser Val Thr Val Pro His Pro Asn Ile Glu 165 170 175 Glu Val Ala Leu
Ser Asn Thr Gly Glu Ile Pro Phe Tyr Gly Lys Ala 180 185 190 Ile Pro
Ile Glu Ala Ile Arg Gly Gly Arg His Leu Ile Phe Cys His 195 200 205
Ser Lys Lys Lys Cys Asp Glu Leu Ala Ala Lys Leu Ser Gly Leu Gly 210
215 220 Ile Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val Ile
Pro 225 230 235 240 Thr Ile Gly Asp Val Val Val Val Ala Thr Asp Ala
Leu Met Thr Gly 245 250 255 Tyr Thr Gly Asp Phe Asp Ser Val Ile Asp
Cys Asn Thr Cys Val Thr 260 265 270 Gln Thr Val Asp Phe Ser 275 275
278 PRT hepatitis C virus 275 Gly Val Ala Lys Ala Val Asp Phe Ile
Pro Val Glu Ser Met Glu Thr 1 5 10 15 Thr Met Arg Ser Pro Val Phe
Thr Asp Asn Ser Ser Pro Pro Ala Val 20 25 30 Pro Gln Thr Phe Gln
Val Ala His Leu His Ala Pro Thr Gly Ser Gly 35 40 45 Lys Ser Thr
Lys Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr Lys Val 50 55 60 Leu
Val Leu Asn Pro Ser Val Ala Ala Thr Leu Gly Phe Gly Ala Tyr 65 70
75 80 Met Ser Lys Ala His Gly Val Asp Pro Asn Ile Ser Thr Gly Val
Arg 85 90 95 Thr Ile Thr Thr Gly Ala Pro Ile Thr Tyr Ser Thr Tyr
Gly Lys Phe 100 105 110 Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala Tyr
Asp Ile Ile Ile Cys 115 120 125 Asp Glu Cys His Ser Thr Asp Ser Thr
Ser Ile Leu Gly Ile Gly Thr 130 135 140 Val Leu Asp Gln Ala Glu Thr
Ala Gly Ala Arg Leu Val Val Leu Ala 145 150 155 160 Thr Ala Thr Pro
Pro Gly Ser Val Thr Val Pro His Pro Asn Ile Glu 165 170 175 Glu Val
Ala Leu Pro Asn Thr Gly Glu Ile Pro Phe Tyr Gly Lys Ala 180 185 190
Ile Pro Leu Glu Thr Ile Lys Gly Gly Arg His Leu Ile Phe Cys His 195
200 205 Ser Lys Lys Lys Cys Asp Glu Leu Ala Ala Lys Leu Ser Ala Leu
Gly 210 215 220 Val Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser
Val Ile Pro 225 230 235 240 Thr Ser Gly Asp Val Val Val Val Ala Thr
Asp Ala Leu Met Thr Gly 245 250 255 Tyr Thr Gly Asp Phe Asp Ser Val
Ile Asp Cys Asn Thr Cys Val Thr 260 265 270 Gln Thr Val Asp Phe Ser
275 276 278 PRT hepatitis C virus 276 Gly Val Ala Lys Ala Val Asp
Phe Val Pro Val Glu Ser Met Glu Thr 1 5 10 15 Thr Met Arg Ser Pro
Val Phe Thr Asp Asn Ser Ser Pro Pro Ala Val 20 25 30 Pro Gln Ala
Phe Gln Val Ala His Leu His Ala Pro Thr Gly Ser Gly 35 40 45 Lys
Ser Thr Lys Val Pro Ala Ala Tyr Ala Ala Gln Gly Tyr Lys Val 50 55
60 Leu Val Leu Asn Pro Ser Val Ala Ala Thr Leu Gly Phe Gly Ala Tyr
65 70 75 80 Met Ser Lys Ala His Gly Val Asp Pro Asn Ile Arg Thr Gly
Val Arg 85 90 95 Thr Ile Thr Thr Gly Ala Pro Ile Thr Tyr Ser Thr
Tyr Gly Lys Phe 100 105 110 Leu Ala Asp Gly Gly Cys Ser Gly Gly Ala
Tyr Asp Ile Ile Met Cys 115 120 125 Asp Glu Cys His Ser Thr Asp Ser
Thr Thr Ile Leu Gly Ile Gly Thr 130 135 140 Val Leu Asp Gln Ala Glu
Thr Ala Gly Ala Arg Leu Val Val Leu Ala 145 150 155 160 Thr Ala Thr
Pro Pro Gly Ser Val Thr Val Pro His Pro Asn Ile Glu 165 170 175 Glu
Ile Ala Leu Ser Asn Thr Gly Glu Ile Pro Phe Tyr Gly Lys Ala 180 185
190 Ile Pro Ile Glu Thr Ile Lys Gly Gly Arg His Leu Ile Phe Cys His
195 200 205 Ser Lys Lys Lys Cys Asp Glu Leu Ala Ala Lys Leu Ser Ala
Leu Gly 210 215 220 Ile His Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val
Ser Val Ile Pro 225 230 235 240 Ala Ser Gly Asn Val Val Val Val Ala
Thr Asp Ala Leu Met Thr Gly
245 250 255 Phe Thr Gly Asp Phe Asp Ser Val Ile Asp Cys Asn Thr Cys
Val Thr 260 265 270 Gln Thr Val Asp Phe Ser 275 277 277 PRT
hepatitis C virus 277 Gly Val Ala Lys Ser Ile Asp Phe Ile Pro Val
Glu Thr Leu Asp Ile 1 5 10 15 Val Thr Arg Ser Pro Thr Phe Ser Asp
Asn Ser Thr Pro Pro Ala Val 20 25 30 Pro Gln Thr Tyr Gln Val Gly
Tyr Leu His Ala Pro Thr Gly Ser Gly 35 40 45 Lys Ser Thr Lys Val
Pro Val Ala Tyr Ala Ala Gln Gly Tyr Lys Val 50 55 60 Leu Val Leu
Asn Pro Ser Val Ala Ala Thr Leu Gly Phe Gly Ala Tyr 65 70 75 80 Leu
Ser Lys Ala His Gly Ile Pro Asn Ile Arg Thr Gly Val Arg Thr 85 90
95 Val Thr Thr Gly Ala Pro Ile Thr Tyr Ser Thr Tyr Gly Lys Phe Leu
100 105 110 Ala Asp Gly Gly Cys Ala Gly Gly Ala Tyr Asp Ile Ile Ile
Cys Asp 115 120 125 Glu Cys His Ala Val Asp Ser Thr Thr Ile Leu Gly
Ile Gly Thr Val 130 135 140 Leu Asp Gln Ala Glu Thr Ala Gly Val Arg
Leu Thr Val Leu Ala Thr 145 150 155 160 Ala Thr Pro Pro Gly Ser Val
Thr Thr Pro His Pro Asn Ile Glu Glu 165 170 175 Val Ala Leu Gly Gln
Glu Gly Glu Ile Pro Phe Tyr Gly Arg Ala Ile 180 185 190 Pro Leu Ser
Tyr Ile Lys Gly Gly Arg His Leu Ile Phe Cys His Ser 195 200 205 Lys
Lys Lys Cys Asp Glu Leu Ala Ala Ala Leu Arg Gly Met Gly Leu 210 215
220 Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val Ile Pro Thr
225 230 235 240 Gln Gly Asp Val Val Val Val Ala Thr Asp Ala Leu Met
Thr Gly Phe 245 250 255 Thr Gly Asp Phe Asp Ser Val Ile Asp Cys Asn
Val Ala Val Thr Gln 260 265 270 Val Val Asp Phe Ser 275 278 277 PRT
hepatitis C virus 278 Gly Val Ala Lys Ser Ile Asp Phe Ile Pro Val
Glu Ser Leu Asp Val 1 5 10 15 Ala Thr Arg Thr Pro Ser Phe Ser Asp
Asn Ser Thr Pro Pro Ala Val 20 25 30 Pro Gln Ser Tyr Gln Val Gly
Tyr Leu His Ala Pro Thr Gly Ser Gly 35 40 45 Lys Ser Thr Lys Val
Pro Ala Ala Tyr Ala Ser Gln Gly Tyr Lys Val 50 55 60 Leu Val Leu
Asn Pro Ser Val Ala Ala Thr Leu Gly Phe Gly Ala Tyr 65 70 75 80 Met
Ser Lys Ala His Gly Ile Pro Asn Ile Arg Thr Gly Val Arg Thr 85 90
95 Val Thr Thr Gly Asp Ser Ile Thr Tyr Ser Thr Tyr Gly Lys Phe Ile
100 105 110 Ala Asp Gly Gly Cys Ala Ala Gly Ala Tyr Asp Ile Ile Ile
Cys Asp 115 120 125 Glu Cys His Ser Val Asp Ala Thr Thr Ile Leu Gly
Ile Gly Thr Val 130 135 140 Leu Asp Gln Ala Glu Thr Ala Gly Val Arg
Leu Val Val Leu Ala Thr 145 150 155 160 Ala Thr Pro Pro Gly Thr Val
Thr Thr Pro His Ser Asn Ile Glu Glu 165 170 175 Val Ala Leu Gly His
Glu Gly Glu Ile Pro Phe Tyr Gly Lys Ala Ile 180 185 190 Pro Leu Ala
Phe Ile Lys Gly Gly Arg His Leu Ile Phe Cys His Ser 195 200 205 Lys
Lys Lys Cys Asp Glu Leu Ala Ala Ala Leu Arg Gly Met Gly Val 210 215
220 Asn Ala Val Ala Tyr Tyr Arg Gly Leu Asp Val Ser Val Ile Pro Thr
225 230 235 240 Gln Gly Asp Val Val Val Val Ala Thr Asp Ala Leu Met
Thr Gly Tyr 245 250 255 Thr Gly Asp Phe Asp Ser Val Ile Asp Cys Asn
Val Ala Val Ser Gln 260 265 270 Ile Val Asp Phe Ser 275 279 149 PRT
hepatitis C virus MISC_FEATURE (30)..(30) Xaa is any amino acid 279
Asp Gly Val Asn Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser 1 5
10 15 Ile Phe Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Xaa Thr
Ala 20 25 30 His Glu Val Arg Asn Ala Ser Gly Val Tyr His Val Thr
Asn Asp Cys 35 40 45 Ser Asn Ser Ser Ile Ile Tyr Glu Met Asp Gly
Met Ile Met His Tyr 50 55 60 Pro Gly Cys Val Pro Cys Val Arg Glu
Asp Asn His Leu Arg Cys Trp 65 70 75 80 Met Ala Leu Thr Pro Thr Leu
Ala Val Lys Xaa Ala Ser Val Pro Thr 85 90 95 Xaa Ala Ile Arg Arg
His Val Asp Leu Leu Val Gly Xaa Xaa Thr Phe 100 105 110 Cys Ser Ala
Met Tyr Val Xaa Asp Leu Cys Gly Ser Val Phe Leu Ala 115 120 125 Gly
Gln Leu Phe Thr Phe Ser Pro Arg Met His His Thr Thr Gln Glu 130 135
140 Cys Asn Cys Ser Ile 145 280 149 PRT hepatitis C virus
MISC_FEATURE (82)..(82) Xaa is any amino acid 280 Asp Gly Val Asn
Tyr Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser 1 5 10 15 Ile Phe
Leu Leu Ala Phe Leu Ser Cys Leu Thr Val Pro Thr Thr Ala 20 25 30
His Glu Val Arg Asn Ala Ser Gly Val Tyr His Leu Thr Asn Asp Cys 35
40 45 Ser Asn Ser Ser Ile Ile Tyr Glu Met Ser Gly Met Ile Leu His
Ala 50 55 60 Pro Gly Cys Val Pro Cys Val Arg Glu Asn Asn Ser Ser
Arg Cys Trp 65 70 75 80 Met Xaa Leu Thr Pro Thr Leu Ala Val Lys Asp
Ala Asn Val Pro Thr 85 90 95 Ala Ala Ile Arg Arg His Val Asp Leu
Leu Val Gly Thr Ala Ala Phe 100 105 110 Arg Ser Ala Met Tyr Val Gly
Asp Leu Cys Gly Ser Val Phe Leu Val 115 120 125 Gly Gln Leu Phe Thr
Phe Ser Pro Arg Leu Tyr His Thr Thr Gln Glu 130 135 140 Cys Asn Cys
Ser Ile 145 281 37 PRT hepatitis C virus MISC_FEATURE (1)..(1) Xaa
is any amino acid 281 Xaa Arg Ser Arg Asn Asn Gly Lys Val Asn Asp
Thr Leu Xaa Cys Gly 1 5 10 15 Phe Ala Asp Leu Met Gly Tyr Ile Pro
Leu Val Xaa Xaa Pro Leu Gly 20 25 30 Gly Ile Glu Arg Ala 35 282 15
PRT hepatitis C virus 282 Tyr Ile Pro Leu Val Gly Ala Pro Leu Asn
Gly Ala Ala Arg Ala 1 5 10 15 283 149 PRT hepatitis C virus
MISC_FEATURE (121)..(121) Xaa is any amino acid 283 Asp Gly Ile Asn
Phe Ala Thr Gly Asn Leu Pro Gly Cys Ser Phe Ser 1 5 10 15 Ile Phe
Leu Leu Ala Leu Leu Ser Cys Leu Thr Val Pro Ala Ser Ala 20 25 30
Ile Asn Tyr Arg Asn Val Ser Gly Ile Tyr Tyr Val Thr Asn Asp Cys 35
40 45 Pro Asn Ser Ser Ile Val Tyr Glu Ala Asp His His Ile Leu His
Leu 50 55 60 Pro Gly Cys Val Pro Cys Val Arg Glu Gly Asn Gln Ser
Arg Cys Trp 65 70 75 80 Val Ala Leu Thr Pro Thr Val Ala Ala Pro Tyr
Ile Gly Ala Pro Leu 85 90 95 Glu Ser Leu Arg Ser His Val Asp Leu
Met Val Gly Ala Ala Thr Val 100 105 110 Cys Ser Ala Leu Tyr Ile Gly
Asp Xaa Cys Xaa Gly Leu Phe Leu Val 115 120 125 Gly Gln Met Phe Ser
Phe Arg Pro Arg Arg His Trp Thr Thr Gln Asp 130 135 140 Cys Asn Cys
Ser Ile 145 284 149 PRT hepatitis C virus MISC_FEATURE (85)..(85)
Xaa is any amino acid 284 Asp Gly Ile Asn Phe Ala Thr Gly Asn Leu
Pro Gly Cys Ser Phe Ser 1 5 10 15 Ile Phe Leu Leu Ala Leu Phe Ser
Cys Leu Leu Thr Pro Thr Ala Gly 20 25 30 Leu Glu Tyr Arg Asn Ala
Ser Gly Leu Tyr Met Val Thr Asn Asp Cys 35 40 45 Ser Asn Gly Ser
Ile Val Tyr Glu Ala Gly Asp Ile Ile Leu His Leu 50 55 60 Pro Gly
Cys Val Pro Cys Val Arg Ser Gly Asn Thr Ser Arg Cys Trp 65 70 75 80
Ile Pro Val Ser Xaa Thr Val Ala Val Lys Ser Pro Cys Ala Ala Thr 85
90 95 Ala Ser Leu Arg Thr His Val Asp Met Met Val Xaa Ala Ala Thr
Leu 100 105 110 Cys Ser Ala Leu Tyr Val Gly Asp Leu Cys Gly Ala Leu
Phe Leu Xaa 115 120 125 Gly Gln Gly Phe Ser Trp Arg His Arg Gln His
Trp Thr Val Gln Asp 130 135 140 Cys Asn Cys Ser Ile 145 285 24 PRT
hepatitis C virus MISC_FEATURE (3)..(4) Xaa is any amino acid 285
Thr Cys Xaa Xaa Ala Asp Leu Met Gly Tyr Xaa Pro Val Val Gly Ala 1 5
10 15 Pro Val Gly Gly Xaa Ala Arg Ala 20 286 19 PRT hepatitis C
virus 286 Val Gln Asp Cys Asn Cys Ser Ile Tyr Pro Gly His Ile Thr
Gly His 1 5 10 15 Arg Met Ala
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