U.S. patent application number 10/369339 was filed with the patent office on 2004-02-05 for altered ospa of borrelia burgdorferi. This patent application is currently assigned to Research Foundation of the State University of New York. Invention is credited to Dunn, John J., Koide, Shohei, Lawson, Catherine L., Luft, Benjamin J..
Application Number | 20040023325 10/369339 |
Document ID | / |
Family ID | 22849087 |
Filed Date | 2004-02-05 |
United States Patent Application | 20040023325 |
Kind Code | A1 |
Luft, Benjamin J. ; et al. | February 5, 2004 |
Provided herein are OspA polypeptides from Lyme Disease-causing Borrelia having certain alteration(s). In one embodiment, the alteration(s) increase the conformational stability of the OspA polypeptide containing the alteration(s) while maintaining at least some of the antigenicity of the corresponding unaltered OspA polypeptide. In another embodiment, the altered OspA polypeptide has reduced cross-reactivity to hLFA-1, as compared to the corresponding unaltered OspA polypeptide.
Inventors: | Luft, Benjamin J.; (East Setauket, NY) ; Dunn, John J.; (Bellport, NY) ; Koide, Shohei; (Chicago, IL) ; Lawson, Catherine L.; (Piscataway, NJ) |
Correspondence Address: |
HAMILTON, BROOK, SMITH & REYNOLDS, P.C. 530 VIRGINIA ROAD P.O. BOX 9133 CONCORD MA 01742-9133 US |
Assignee: | Research Foundation of the State
University of New York Stony Brook NY Brookhaven Sciences Associates, LLC Upton NY University of Rochester Rochester NY |
Family ID: | 22849087 |
Appl. No.: | 10/369339 |
Filed: | February 18, 2003 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
10369339 | Feb 18, 2003 | |||
PCT/US01/25852 | Aug 17, 2001 | |||
60226484 | Aug 18, 2000 | |||
Current U.S. Class: | 435/69.1 ; 435/252.3; 435/320.1; 530/350; 536/23.7 |
Current CPC Class: | C07K 2319/00 20130101; Y02A 50/30 20180101; A61K 39/00 20130101; C07K 14/20 20130101; Y02A 50/401 20180101 |
Class at Publication: | 435/69.1 ; 435/252.3; 435/320.1; 530/350; 536/23.7 |
International Class: | C12P 021/02; C12N 001/21; C07K 014/195; C12N 015/74 |
Sequence CWU 1
1
130 1 23 DNA Artificial Sequence Oligonucleotide Primer 1
cttaatgact ctgacactag tgc 23 2 30 DNA Artificial Sequence
Oligonucleotide Primer 2 gctactaaaa aaaccgggaa atggaattca 30 3 33
DNA Artificial Sequence Oligonucleotide Primer 3 gcagcttggg
attcaaaaac atccacttta aca 33 4 18 DNA Artificial Sequence
Oligonucleotide Primer 4 ggagaatata ttatgaaa 18 5 17 DNA Artificial
Sequence Oligonucleotide Primer 5 ctccttattt taaagcg 17 6 822 DNA
Borrelia burgdorferi CDS (1)...(822) 6 atg aaa aaa tat tta ttg gga
ata ggt cta ata tta gcc tta ata gca 48 Met Lys Lys Tyr Leu Leu Gly
Ile Gly Leu Ile Leu Ala Leu Ile Ala 1 5 10 15 tgt aag caa aat gtt
agc agc ctt gac gag aaa aac agc gtt tca gta 96 Cys Lys Gln Asn Val
Ser Ser Leu Asp Glu Lys Asn Ser Val Ser Val 20 25 30 gat ttg cct
ggt gaa atg aaa gtt ctt gta agc aaa gaa aaa aac aaa 144 Asp Leu Pro
Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys Asn Lys 35 40 45 gac
ggc aag tac gat cta att gca aca gta gac aag ctt gag ctt aaa 192 Asp
Gly Lys Tyr Asp Leu Ile Ala Thr Val Asp Lys Leu Glu Leu Lys 50 55
60 gga act tct gat aaa aac aat gga tct gga gta ctt gaa ggc gta aaa
240 Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Val Leu Glu Gly Val Lys
65 70 75 80 gct gac aaa agt aaa gta aaa tta aca att tct gac gat cta
ggt caa 288 Ala Asp Lys Ser Lys Val Lys Leu Thr Ile Ser Asp Asp Leu
Gly Gln 85 90 95 acc aca ctt gaa gtt ttc aaa gaa gat ggc aaa aca
cta gta tca aaa 336 Thr Thr Leu Glu Val Phe Lys Glu Asp Gly Lys Thr
Leu Val Ser Lys 100 105 110 aaa gta act tcc aaa gac aag tca tca aca
gaa gaa aaa ttc aat gaa 384 Lys Val Thr Ser Lys Asp Lys Ser Ser Thr
Glu Glu Lys Phe Asn Glu 115 120 125 aaa ggt gaa gta tct gaa aaa ata
ata aca aga gca gac gga acc aga 432 Lys Gly Glu Val Ser Glu Lys Ile
Ile Thr Arg Ala Asp Gly Thr Arg 130 135 140 ctt gaa tac aca gga att
aaa agc gat gga tct gga aaa gct aaa gag 480 Leu Glu Tyr Thr Gly Ile
Lys Ser Asp Gly Ser Gly Lys Ala Lys Glu 145 150 155 160 gtt tta aaa
ggc tat gtt ctt gaa gga act cta act gct gaa aaa aca 528 Val Leu Lys
Gly Tyr Val Leu Glu Gly Thr Leu Thr Ala Glu Lys Thr 165 170 175 aca
ttg gtg gtt aaa gaa gga act gtt act tta agc aaa aat att tca 576 Thr
Leu Val Val Lys Glu Gly Thr Val Thr Leu Ser Lys Asn Ile Ser 180 185
190 aaa tct ggg gaa gtt tca gtt gaa ctt aat gac act gac agt agt gct
624 Lys Ser Gly Glu Val Ser Val Glu Leu Asn Asp Thr Asp Ser Ser Ala
195 200 205 gct act aaa aaa act gca gct tgg aat tca ggc act tca act
tta aca 672 Ala Thr Lys Lys Thr Ala Ala Trp Asn Ser Gly Thr Ser Thr
Leu Thr 210 215 220 att act gta aac agt aaa aaa act aaa gac ctt gtg
ttt aca aaa gaa 720 Ile Thr Val Asn Ser Lys Lys Thr Lys Asp Leu Val
Phe Thr Lys Glu 225 230 235 240 aac aca att aca gta caa caa tac gac
tca aat ggc acc aaa tta gag 768 Asn Thr Ile Thr Val Gln Gln Tyr Asp
Ser Asn Gly Thr Lys Leu Glu 245 250 255 ggg tca gca gtt gaa att aca
aaa ctt gat gaa att aaa aac gct tta 816 Gly Ser Ala Val Glu Ile Thr
Lys Leu Asp Glu Ile Lys Asn Ala Leu 260 265 270 aaa taa 822 Lys * 7
273 PRT Borrelia burgdorferi 7 Met Lys Lys Tyr Leu Leu Gly Ile Gly
Leu Ile Leu Ala Leu Ile Ala 1 5 10 15 Cys Lys Gln Asn Val Ser Ser
Leu Asp Glu Lys Asn Ser Val Ser Val 20 25 30 Asp Leu Pro Gly Glu
Met Lys Val Leu Val Ser Lys Glu Lys Asn Lys 35 40 45 Asp Gly Lys
Tyr Asp Leu Ile Ala Thr Val Asp Lys Leu Glu Leu Lys 50 55 60 Gly
Thr Ser Asp Lys Asn Asn Gly Ser Gly Val Leu Glu Gly Val Lys 65 70
75 80 Ala Asp Lys Ser Lys Val Lys Leu Thr Ile Ser Asp Asp Leu Gly
Gln 85 90 95 Thr Thr Leu Glu Val Phe Lys Glu Asp Gly Lys Thr Leu
Val Ser Lys 100 105 110 Lys Val Thr Ser Lys Asp Lys Ser Ser Thr Glu
Glu Lys Phe Asn Glu 115 120 125 Lys Gly Glu Val Ser Glu Lys Ile Ile
Thr Arg Ala Asp Gly Thr Arg 130 135 140 Leu Glu Tyr Thr Gly Ile Lys
Ser Asp Gly Ser Gly Lys Ala Lys Glu 145 150 155 160 Val Leu Lys Gly
Tyr Val Leu Glu Gly Thr Leu Thr Ala Glu Lys Thr 165 170 175 Thr Leu
Val Val Lys Glu Gly Thr Val Thr Leu Ser Lys Asn Ile Ser 180 185 190
Lys Ser Gly Glu Val Ser Val Glu Leu Asn Asp Thr Asp Ser Ser Ala 195
200 205 Ala Thr Lys Lys Thr Ala Ala Trp Asn Ser Gly Thr Ser Thr Leu
Thr 210 215 220 Ile Thr Val Asn Ser Lys Lys Thr Lys Asp Leu Val Phe
Thr Lys Glu 225 230 235 240 Asn Thr Ile Thr Val Gln Gln Tyr Asp Ser
Asn Gly Thr Lys Leu Glu 245 250 255 Gly Ser Ala Val Glu Ile Thr Lys
Leu Asp Glu Ile Lys Asn Ala Leu 260 265 270 Lys 8 825 DNA Borrelia
burgdorferi CDS (1)...(825) 8 atg aaa aaa tat tta ttg gga ata ggt
cta ata tta gcc tta ata gca 48 Met Lys Lys Tyr Leu Leu Gly Ile Gly
Leu Ile Leu Ala Leu Ile Ala 1 5 10 15 tgt aag caa aat gtt agc agc
ctt gat gaa aaa aat agc gtt tca gta 96 Cys Lys Gln Asn Val Ser Ser
Leu Asp Glu Lys Asn Ser Val Ser Val 20 25 30 gat tta cct ggt gga
atg aca gtt ctt gta agt aaa gaa aaa gac aaa 144 Asp Leu Pro Gly Gly
Met Thr Val Leu Val Ser Lys Glu Lys Asp Lys 35 40 45 gac ggt aaa
tac agt cta gag gca aca gta gac aag ctt gag ctt aaa 192 Asp Gly Lys
Tyr Ser Leu Glu Ala Thr Val Asp Lys Leu Glu Leu Lys 50 55 60 gga
act tct gat aaa aac aac ggt tct gga aca ctt gaa ggt gaa aaa 240 Gly
Thr Ser Asp Lys Asn Asn Gly Ser Gly Thr Leu Glu Gly Glu Lys 65 70
75 80 act gac aaa agt aaa gta aaa tta aca att gct gat gac cta agt
caa 288 Thr Asp Lys Ser Lys Val Lys Leu Thr Ile Ala Asp Asp Leu Ser
Gln 85 90 95 act aaa ttt gaa att ttc aaa gaa gat gcc aaa aca tta
gta tca aaa 336 Thr Lys Phe Glu Ile Phe Lys Glu Asp Ala Lys Thr Leu
Val Ser Lys 100 105 110 aaa gta acc ctt aaa gac aag tca tca aca gaa
gaa aaa ttc aac gaa 384 Lys Val Thr Leu Lys Asp Lys Ser Ser Thr Glu
Glu Lys Phe Asn Glu 115 120 125 aag ggt gaa aca tct gaa aaa aca ata
gta aga gca aat gga acc aga 432 Lys Gly Glu Thr Ser Glu Lys Thr Ile
Val Arg Ala Asn Gly Thr Arg 130 135 140 ctt gaa tac aca gac ata aaa
agc gat gga tcc gga aaa gct aaa gaa 480 Leu Glu Tyr Thr Asp Ile Lys
Ser Asp Gly Ser Gly Lys Ala Lys Glu 145 150 155 160 gtt tta aaa gac
ttt act ctt gaa gga act cta gct gct gac ggc aaa 528 Val Leu Lys Asp
Phe Thr Leu Glu Gly Thr Leu Ala Ala Asp Gly Lys 165 170 175 aca aca
ttg aaa gtt aca gaa ggc act gtt gtt tta agc aag aac att 576 Thr Thr
Leu Lys Val Thr Glu Gly Thr Val Val Leu Ser Lys Asn Ile 180 185 190
tta aaa tcc gga gaa ata aca gtt gca ctt gat gac tct gac act act 624
Leu Lys Ser Gly Glu Ile Thr Val Ala Leu Asp Asp Ser Asp Thr Thr 195
200 205 cag gct act aaa aaa act gga aaa tgg gat tca aaa act tcc act
tta 672 Gln Ala Thr Lys Lys Thr Gly Lys Trp Asp Ser Lys Thr Ser Thr
Leu 210 215 220 aca att agt gtg aat agc caa aaa acc aaa aac ctt gta
ttc aca aaa 720 Thr Ile Ser Val Asn Ser Gln Lys Thr Lys Asn Leu Val
Phe Thr Lys 225 230 235 240 gaa gac aca ata aca gta caa aaa tac gac
tca gca ggc acc aat cta 768 Glu Asp Thr Ile Thr Val Gln Lys Tyr Asp
Ser Ala Gly Thr Asn Leu 245 250 255 gaa ggc aaa gca gtc gaa att aca
aca ctt aaa gaa ctt aaa aac gct 816 Glu Gly Lys Ala Val Glu Ile Thr
Thr Leu Lys Glu Leu Lys Asn Ala 260 265 270 tta aaa taa 825 Leu Lys
* 9 274 PRT Borrelia burgdorferi 9 Met Lys Lys Tyr Leu Leu Gly Ile
Gly Leu Ile Leu Ala Leu Ile Ala 1 5 10 15 Cys Lys Gln Asn Val Ser
Ser Leu Asp Glu Lys Asn Ser Val Ser Val 20 25 30 Asp Leu Pro Gly
Gly Met Thr Val Leu Val Ser Lys Glu Lys Asp Lys 35 40 45 Asp Gly
Lys Tyr Ser Leu Glu Ala Thr Val Asp Lys Leu Glu Leu Lys 50 55 60
Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Thr Leu Glu Gly Glu Lys 65
70 75 80 Thr Asp Lys Ser Lys Val Lys Leu Thr Ile Ala Asp Asp Leu
Ser Gln 85 90 95 Thr Lys Phe Glu Ile Phe Lys Glu Asp Ala Lys Thr
Leu Val Ser Lys 100 105 110 Lys Val Thr Leu Lys Asp Lys Ser Ser Thr
Glu Glu Lys Phe Asn Glu 115 120 125 Lys Gly Glu Thr Ser Glu Lys Thr
Ile Val Arg Ala Asn Gly Thr Arg 130 135 140 Leu Glu Tyr Thr Asp Ile
Lys Ser Asp Gly Ser Gly Lys Ala Lys Glu 145 150 155 160 Val Leu Lys
Asp Phe Thr Leu Glu Gly Thr Leu Ala Ala Asp Gly Lys 165 170 175 Thr
Thr Leu Lys Val Thr Glu Gly Thr Val Val Leu Ser Lys Asn Ile 180 185
190 Leu Lys Ser Gly Glu Ile Thr Val Ala Leu Asp Asp Ser Asp Thr Thr
195 200 205 Gln Ala Thr Lys Lys Thr Gly Lys Trp Asp Ser Lys Thr Ser
Thr Leu 210 215 220 Thr Ile Ser Val Asn Ser Gln Lys Thr Lys Asn Leu
Val Phe Thr Lys 225 230 235 240 Glu Asp Thr Ile Thr Val Gln Lys Tyr
Asp Ser Ala Gly Thr Asn Leu 245 250 255 Glu Gly Lys Ala Val Glu Ile
Thr Thr Leu Lys Glu Leu Lys Asn Ala 260 265 270 Leu Lys 10 822 DNA
Borrelia burgdorferi CDS (1)...(822) 10 atg aaa aaa tat tta ttg gga
ata ggt cta ata tta gcc tta ata gca 48 Met Lys Lys Tyr Leu Leu Gly
Ile Gly Leu Ile Leu Ala Leu Ile Ala 1 5 10 15 tgc aag caa aat gtt
agc agc ctt gat gaa aaa aac agc gct tca gta 96 Cys Lys Gln Asn Val
Ser Ser Leu Asp Glu Lys Asn Ser Ala Ser Val 20 25 30 gat ttg cct
ggt gag atg aaa gtt ctt gta agt aaa gaa aaa gac aaa 144 Asp Leu Pro
Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys Asp Lys 35 40 45 gac
ggt aag tac agt cta aag gca aca gta gac aag att gag cta aaa 192 Asp
Gly Lys Tyr Ser Leu Lys Ala Thr Val Asp Lys Ile Glu Leu Lys 50 55
60 gga act tct gat aaa gac aat ggt tct gga gtg ctt gaa ggt aca aaa
240 Gly Thr Ser Asp Lys Asp Asn Gly Ser Gly Val Leu Glu Gly Thr Lys
65 70 75 80 gat gac aaa agt aaa gca aaa tta aca att gct gac gat cta
agt aaa 288 Asp Asp Lys Ser Lys Ala Lys Leu Thr Ile Ala Asp Asp Leu
Ser Lys 85 90 95 acc aca ttc gaa ctt tta aaa gaa gat ggc aaa aca
tta gtg tca aga 336 Thr Thr Phe Glu Leu Leu Lys Glu Asp Gly Lys Thr
Leu Val Ser Arg 100 105 110 aaa gta agt tct aga gac aaa aca tca aca
gat gaa atg ttc aat gaa 384 Lys Val Ser Ser Arg Asp Lys Thr Ser Thr
Asp Glu Met Phe Asn Glu 115 120 125 aaa ggt gaa ttg tct gca aaa acc
atg aca aga gaa aat gga acc aaa 432 Lys Gly Glu Leu Ser Ala Lys Thr
Met Thr Arg Glu Asn Gly Thr Lys 130 135 140 ctt gaa tat aca gaa atg
aaa agc gat gga acc gga aaa gct aaa gaa 480 Leu Glu Tyr Thr Glu Met
Lys Ser Asp Gly Thr Gly Lys Ala Lys Glu 145 150 155 160 gtt tta aaa
aag ttt act ctt gaa gga aaa gta gct aat gat aaa gta 528 Val Leu Lys
Lys Phe Thr Leu Glu Gly Lys Val Ala Asn Asp Lys Val 165 170 175 aca
ttg gaa gta aaa gaa gga acc gtt act tta agt aag gaa att gca 576 Thr
Leu Glu Val Lys Glu Gly Thr Val Thr Leu Ser Lys Glu Ile Ala 180 185
190 aaa tct gga gaa gta aca gtt gct ctt aat gac act aac act act cag
624 Lys Ser Gly Glu Val Thr Val Ala Leu Asn Asp Thr Asn Thr Thr Gln
195 200 205 gct act aaa aaa act ggc gca tgg gat tca aaa act tct act
tta aca 672 Ala Thr Lys Lys Thr Gly Ala Trp Asp Ser Lys Thr Ser Thr
Leu Thr 210 215 220 att agt gtt aac agc aaa aaa act aca caa ctt gtg
ttt act aaa caa 720 Ile Ser Val Asn Ser Lys Lys Thr Thr Gln Leu Val
Phe Thr Lys Gln 225 230 235 240 tac aca ata act gta aaa caa tac gac
tcc gca ggt acc aat tta gaa 768 Tyr Thr Ile Thr Val Lys Gln Tyr Asp
Ser Ala Gly Thr Asn Leu Glu 245 250 255 ggc aca gca gtc gaa att aaa
aca ctt gat gaa ctt aaa aac gct tta 816 Gly Thr Ala Val Glu Ile Lys
Thr Leu Asp Glu Leu Lys Asn Ala Leu 260 265 270 aaa taa 822 Lys *
11 273 PRT Borrelia burgdorferi 11 Met Lys Lys Tyr Leu Leu Gly Ile
Gly Leu Ile Leu Ala Leu Ile Ala 1 5 10 15 Cys Lys Gln Asn Val Ser
Ser Leu Asp Glu Lys Asn Ser Ala Ser Val 20 25 30 Asp Leu Pro Gly
Glu Met Lys Val Leu Val Ser Lys Glu Lys Asp Lys 35 40 45 Asp Gly
Lys Tyr Ser Leu Lys Ala Thr Val Asp Lys Ile Glu Leu Lys 50 55 60
Gly Thr Ser Asp Lys Asp Asn Gly Ser Gly Val Leu Glu Gly Thr Lys 65
70 75 80 Asp Asp Lys Ser Lys Ala Lys Leu Thr Ile Ala Asp Asp Leu
Ser Lys 85 90 95 Thr Thr Phe Glu Leu Leu Lys Glu Asp Gly Lys Thr
Leu Val Ser Arg 100 105 110 Lys Val Ser Ser Arg Asp Lys Thr Ser Thr
Asp Glu Met Phe Asn Glu 115 120 125 Lys Gly Glu Leu Ser Ala Lys Thr
Met Thr Arg Glu Asn Gly Thr Lys 130 135 140 Leu Glu Tyr Thr Glu Met
Lys Ser Asp Gly Thr Gly Lys Ala Lys Glu 145 150 155 160 Val Leu Lys
Lys Phe Thr Leu Glu Gly Lys Val Ala Asn Asp Lys Val 165 170 175 Thr
Leu Glu Val Lys Glu Gly Thr Val Thr Leu Ser Lys Glu Ile Ala 180 185
190 Lys Ser Gly Glu Val Thr Val Ala Leu Asn Asp Thr Asn Thr Thr Gln
195 200 205 Ala Thr Lys Lys Thr Gly Ala Trp Asp Ser Lys Thr Ser Thr
Leu Thr 210 215 220 Ile Ser Val Asn Ser Lys Lys Thr Thr Gln Leu Val
Phe Thr Lys Gln 225 230 235 240 Tyr Thr Ile Thr Val Lys Gln Tyr Asp
Ser Ala Gly Thr Asn Leu Glu 245 250 255 Gly Thr Ala Val Glu Ile Lys
Thr Leu Asp Glu Leu Lys Asn Ala Leu 260 265 270 Lys 12 819 DNA
Borrelia burgdorferi CDS (1)...(819) 12 atg aaa aaa tat tta ttg gga
ata ggt cta ata tta gct tta ata gca 48 Met Lys Lys Tyr Leu Leu Gly
Ile Gly Leu Ile Leu Ala Leu Ile Ala 1 5 10 15 tgt aag caa aat gtt
agc agc ctt gac gag aaa aac agc gtt tca gta 96 Cys Lys Gln Asn Val
Ser Ser Leu Asp Glu Lys Asn Ser Val Ser Val 20 25 30 gat ttg cct
ggt gaa atg aaa gtt ctt gta agc aaa gaa aaa gac aaa 144 Asp Leu Pro
Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys Asp Lys 35 40 45 gac
ggc aag tac agt cta atg gca aca gta gac aag ctt gag ctt aaa 192 Asp
Gly Lys Tyr Ser Leu Met Ala Thr Val Asp Lys Leu Glu Leu Lys 50 55
60 gga aca tct gat aaa aac aat gga tct ggg gtg ctt gaa ggc gta aaa
240 Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Val Leu Glu Gly Val Lys
65 70 75 80 gct gac aaa agc aaa gta aaa tta aca gtt tct gac gat cta
agc aca 288 Ala Asp Lys Ser Lys Val Lys Leu Thr Val Ser Asp Asp Leu
Ser Thr 85
90 95 acc aca ctt gaa gtt tta aaa gaa gat ggc aaa aca tta gtg tca
aaa 336 Thr Thr Leu Glu Val Leu Lys Glu Asp Gly Lys Thr Leu Val Ser
Lys 100 105 110 aaa aga act tct aaa gat aag tca tca aca gaa gaa aag
ttc aat gaa 384 Lys Arg Thr Ser Lys Asp Lys Ser Ser Thr Glu Glu Lys
Phe Asn Glu 115 120 125 aaa ggc gaa tta gtt gaa aaa ata atg gca aga
gca aac gga acc ata 432 Lys Gly Glu Leu Val Glu Lys Ile Met Ala Arg
Ala Asn Gly Thr Ile 130 135 140 ctt gaa tac aca gga att aaa agc gat
gga tcc gga aaa gct aaa gaa 480 Leu Glu Tyr Thr Gly Ile Lys Ser Asp
Gly Ser Gly Lys Ala Lys Glu 145 150 155 160 act tta aaa gaa tat gtt
ctt gaa gga act cta act gct gaa aaa gca 528 Thr Leu Lys Glu Tyr Val
Leu Glu Gly Thr Leu Thr Ala Glu Lys Ala 165 170 175 aca ttg gtg gtt
aaa gaa gga act gtt act tta agt aag cac att tca 576 Thr Leu Val Val
Lys Glu Gly Thr Val Thr Leu Ser Lys His Ile Ser 180 185 190 aaa tct
gga gaa gta aca gct gaa ctt aat gac act gac agt act caa 624 Lys Ser
Gly Glu Val Thr Ala Glu Leu Asn Asp Thr Asp Ser Thr Gln 195 200 205
gct act aaa aaa act ggg aaa tgg gat gca ggc act tca act tta aca 672
Ala Thr Lys Lys Thr Gly Lys Trp Asp Ala Gly Thr Ser Thr Leu Thr 210
215 220 att act gta aac aac aaa aaa act aaa gcc ctt gta ttt aca aaa
caa 720 Ile Thr Val Asn Asn Lys Lys Thr Lys Ala Leu Val Phe Thr Lys
Gln 225 230 235 240 gac aca att aca tca caa aaa tac gac tca gca gga
acc aac ttg gaa 768 Asp Thr Ile Thr Ser Gln Lys Tyr Asp Ser Ala Gly
Thr Asn Leu Glu 245 250 255 ggc aca gca gtc gaa att aaa aca ctt gat
gaa ctt aaa aac gct tta 816 Gly Thr Ala Val Glu Ile Lys Thr Leu Asp
Glu Leu Lys Asn Ala Leu 260 265 270 aga 819 Arg 13 273 PRT Borrelia
burgdorferi 13 Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala
Leu Ile Ala 1 5 10 15 Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys
Asn Ser Val Ser Val 20 25 30 Asp Leu Pro Gly Glu Met Lys Val Leu
Val Ser Lys Glu Lys Asp Lys 35 40 45 Asp Gly Lys Tyr Ser Leu Met
Ala Thr Val Asp Lys Leu Glu Leu Lys 50 55 60 Gly Thr Ser Asp Lys
Asn Asn Gly Ser Gly Val Leu Glu Gly Val Lys 65 70 75 80 Ala Asp Lys
Ser Lys Val Lys Leu Thr Val Ser Asp Asp Leu Ser Thr 85 90 95 Thr
Thr Leu Glu Val Leu Lys Glu Asp Gly Lys Thr Leu Val Ser Lys 100 105
110 Lys Arg Thr Ser Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn Glu
115 120 125 Lys Gly Glu Leu Val Glu Lys Ile Met Ala Arg Ala Asn Gly
Thr Ile 130 135 140 Leu Glu Tyr Thr Gly Ile Lys Ser Asp Gly Ser Gly
Lys Ala Lys Glu 145 150 155 160 Thr Leu Lys Glu Tyr Val Leu Glu Gly
Thr Leu Thr Ala Glu Lys Ala 165 170 175 Thr Leu Val Val Lys Glu Gly
Thr Val Thr Leu Ser Lys His Ile Ser 180 185 190 Lys Ser Gly Glu Val
Thr Ala Glu Leu Asn Asp Thr Asp Ser Thr Gln 195 200 205 Ala Thr Lys
Lys Thr Gly Lys Trp Asp Ala Gly Thr Ser Thr Leu Thr 210 215 220 Ile
Thr Val Asn Asn Lys Lys Thr Lys Ala Leu Val Phe Thr Lys Gln 225 230
235 240 Asp Thr Ile Thr Ser Gln Lys Tyr Asp Ser Ala Gly Thr Asn Leu
Glu 245 250 255 Gly Thr Ala Val Glu Ile Lys Thr Leu Asp Glu Leu Lys
Asn Ala Leu 260 265 270 Arg 14 21 DNA Artificial Sequence
Oligonucleotide Primer 14 gtctgcaaaa accatgacaa g 21 15 22 DNA
Artificial Sequence Oligonucleotide Primer 15 gtcatcaaca gaagaaaaat
tc 22 16 30 DNA Artificial Sequence Oligonucleotide Primer 16
ccggatccat atgaaaaaat atttattggg 30 17 32 DNA Artificial Sequence
Oligonucleotide Primer 17 ccgggatcca tatggctaag caaaatgtta gc 32 18
18 DNA Artificial Sequence Oligonucleotide Primer 18 gcgttcaagt
actccaga 18 19 27 DNA Artificial Sequence Oligonucleotide Primer 19
gatatctaga tcttatttta aagcgtt 27 20 31 DNA Artificial Sequence
Oligonucleotide Primer 20 ggatccggtg accttttaaa gcgtttttaa t 31 21
825 DNA Borrelia burgdorferi 21 atgaaaaaat atttattggg aataggtcta
atattagcct taatagcatg taagcaaaat 60 gttagcagcc ttgatgaaaa
aaatagcgtt tcagtagatt tacctggtgg aatgacagtt 120 cttgtaagta
aagaaaaaga caaagacggt aaatacagtc tagaggcaac agtagacaag 180
cttgagctta aaggaacttc tgataaaaac aacggttctg gaacacttga aggtgaaaaa
240 actgacaaaa gtaaagtaaa atcaacaatt gctgatgacc taagtcaaac
taaatttgaa 300 attttcaaag aagatggcaa aacattagta tcaaaaaaag
taacccttaa agacaagtca 360 tcaacagaag aaaaattcaa cggaaagggt
gaaacatctg aaaaaacaat agtaagagca 420 aatggaacca gacttgaata
cacagacata aaaagcgatg gatccggaaa agctaaagaa 480 gttttaaaag
actttactct tgaaggaact ctagctgctg acggcaaaac aacattgaaa 540
gttacagaag gcactgttgt tttaagcaag aacattttaa aatccggaga aataacagct
600 gcacttgatg actctgacac tactcgggct actaaaaaaa ctggaaaatg
ggattcaaag 660 acttccactt taacaattag tgtgaatagc caaaaaacca
aaaaccttgt attcacaaaa 720 gaagacacaa taacagtaca aagatacgac
tcagcaggca ccaatctaga aggcaaagca 780 gtcgaaatta caacacttaa
agaacttaaa aacgctttaa aataa 825 22 824 DNA Borrelia burgdorferi 22
atgaaaaaat atttattggg aataggtcta atattagcat taatagcatg taagcaaaat
60 gttagcagcc ttgatgaaaa aaatagcgtt tcagtagatt tacctggtgg
aatgcaagtt 120 cttgtaagta aagaaaaaga caaagatggt aaatacagtc
taatggcaac agtagacaag 180 cttgagctta aaggaacttc tgataaaaac
aacggttctg gaacacttga aggtgaaaaa 240 actgacaaaa gtaaagcaaa
attaacaatt gctgaggatc taagtaaaac cacatttgaa 300 atcttcaaag
aagatggcaa aacattagta tcaaaaaaag taacccttaa agacaagtca 360
tcaacagaag aaaaattcaa cgcaaagggt gaagcatctg aaaaaacaat agtaagagca
420 aatggaacca gacttgaata cacagacata aaaagcgata aaaccggaaa
agctaaagaa 480 gttttaaaag actttgctct tgaaggaact ctagctgctg
acggcaaaac aacattaaaa 540 gttacagaag gcactgttgt tttaagcaaa
cacatttcaa actctggaga aataacagtt 600 gagcttaatg actctgacac
tactcaggct actaaaaaaa ctggaacatg ggattcaaag 660 acttccactt
taacaattag tgtgaatagc cgaaaaacca aaaaccttgt attcacaaaa 720
gaagacacaa taacagtaca aaaatacgac tcagcaggca ccaatctaga aggcaaagca
780 gtcgaaatta caacgcttaa agaacttaaa gatgctttaa aata 824 23 821 DNA
Borrelia burgdorferi 23 atgaaaaaat atttattggg aataggtcta atattagcct
taatagcatg caagcaaaat 60 gttagcagcc ttgatgaaaa aaacagcgct
tcagtagatt tgcctggtga gatgaaagtt 120 cttgtaagta aagaaaaaga
caaagacggt aagtacagtc taaaggcaac agtagacaag 180 attgagctaa
aaggaacttc tgataaagac aatggttctg gggtgcttga aggtacaaaa 240
gatgacaaaa gtaaagcaaa attaacaatt gctgacgatc taggtaaaac cacattcgaa
300 cttttcaaag aagatggcaa aacattagtg tcaagaaaag taagttctaa
agacaaaaca 360 tcaacagatg aaatgttcaa tgaaaaaggt gaattgtctg
caaaaaccat gacaagagaa 420 aatggaacca aacttgaata tacagaaatg
aaaagcgatg gaaccggaaa agctaaagaa 480 gttttaaaaa actttactct
tgaaggaaaa gtagctaatg ataaagtaac attggaagta 540 aaagaaggaa
ccgttacttt aagtaaggaa attgcaaaat ctggagaagt aacagttgct 600
cttaatgaca ctaacactac tcaggctact aaaaaaactg gcgcatggga ttcaaaaact
660 tctactttaa caattagtgt taacagcaaa aaaactacac aacttgtgtt
tactaaacaa 720 gacacaataa ctgtacaaaa atacgactcc gcaggtacca
atttagaagg cacagcagtc 780 gaaattaaaa cacttgatga acttaaaaac
gctttaaaat a 821 24 821 DNA Borrelia burgdorferi 24 atgaaaaaat
atttattggg aataggtcta atattagcct taatagcatg caagcaaaat 60
gttagcagcc ttgatgaaaa aaacagcgct tcagtagatt tgcctggtga gattaaagtt
120 cttgtaagta aagaaaaaga caaagacggt aagtacagtc taaaggcaac
agtagacaag 180 attgagctaa aaggaacttc tgataaagac aatggttctg
gagtgcttga aggtacaaaa 240 gatgacaaaa gtaaagcaaa attaacaatt
gctgacgatc taagtaaaac cacattcgaa 300 cttttcaaag aagatggcaa
aacattagtg tcaagaaaag taagttctaa agacaaaaca 360 tcaacagatg
aaatgttcaa tgaaaaaggt gaattgtctg caaaaaccat gacaagagaa 420
aatggaacca aacttgaata tacagaaatg aaaagcgatg gaaccggaaa agctaaagaa
480 gttttaaaaa actttactct tgaaggaaaa gtagctaatg ataaagtaac
attggaagta 540 aaagaaggaa ccgttacttt aagtaaggaa attgcaaaat
ctggagaagt aacagttgct 600 cttaatgaca ctaacactac tcaggctact
aaaaaaactg gcgcatggga ttcaaaaact 660 tctactttaa caattagtgt
taacagtaaa aaaactacac aacttgtgtt tactaaacaa 720 gacacaataa
ctgtacaaaa atacgactcc gcaggtacca atttagaagg cacagcagtc 780
gaaattaaaa cacttgatga acttaaaaac gctttaaaat a 821 25 821 DNA
Borrelia burgdorferi 25 atgaaaaaat atttattggg aataggtcta atattagcct
taatagcatg caagcaaaat 60 gttagcagcc ttgatgaaaa aaacagcgct
tcagtagatt tgcctggtga gatgaaagtt 120 cttgtaagta aagaaaaaga
caaagacggt aagtacagtc taaaggcaac agtagacaag 180 attgagctaa
aaggaacttc tgataaagac aatggttctg gggtgcttga aggtacaaaa 240
gatgacaaaa gtaaagcaaa attaacaatt gctgacgatc taggtaaaac cacattcgaa
300 cttttcaaag aagatggcaa aacattagtg tcaagaaaag taagttctaa
agacaaaaca 360 tcaacagatg aaatgttcaa tgaaaaaggt gaattgtctg
caaaaaccat gacaagagaa 420 aatggaacca aacttgaata tacagaaatg
aaaagcgatg gaaccggaaa agctaaagaa 480 gttttaaaaa actttactct
tgaaggaaaa gtagctaatg ataaagtaac attggaagta 540 aaagaaggaa
ccgttacttt aagtaaggaa attgcaaaat ctggagaagt aacagttgct 600
cttaatgaca ctaacactac tcaggctact aaaaaaactg gcgcatggga ttcaaaaact
660 tctactttaa caattagtgt taacagcaaa aaaactacac aacttgtgtt
tactaaacaa 720 gacacaataa ctgtacaaaa atacgactcc gcaggtacca
atttagaagg cacagcagtc 780 gaaattaaaa cacttgatga acttaaaaac
gctttaaaat a 821 26 822 DNA Borrelia burgdorferi 26 atgaaaaaat
atttattggg aataggtcta atattagcct taatagcatg caagcaaaat 60
gttagcagcc ttgatgaaaa aaacagcgct tcagtagatt tgcctggtga gatgaaagtt
120 cttgtaagta aagaaaaaga caaagacggt aagtacagtc taaaggcaac
agtagacaag 180 attgagctaa aaggaacttc tgataaagac aatggttctg
gagtgcttga aggtacaaaa 240 gatgacaaaa gtaaagcaaa attaacaatt
gctgacgatc taagtaaaac cacattcgaa 300 cttttcaaag aagatggcaa
aacattagtg tcaagaaaag taagttctaa agacaaaaca 360 tcaacagatg
aaatgttcaa tgaaaaaggt gaattgtctg caaaaaccat gacaagagaa 420
aatggaacca aacttgaata tacagaaatg aaaagcgatg gaaccggaaa agctaaagaa
480 gttttaaaaa actttactct tgaaggaaaa gtagctaatg ataaagtaac
attggaagta 540 aaagaaggaa ccgttacttt aagtaaggaa attgcaaaat
ctggagaagt aacagttgct 600 cttaatgaca ctaacactac tcaggctact
aaaaaaactg gcgcatggga ttcaaaaact 660 tctactttaa caattagtgt
taacagcaaa aaaactacac aacttgtgtt tactaaacaa 720 gacacaataa
ctgtacaaaa atacgactcc gcaggtacca atttagaagg cacagcagtc 780
gaaattaaaa cacttgatga acttaaaaac gctttgaaat aa 822 27 38 DNA
Artificial Sequence Oligonucleotide Primer 27 aaagtagaag tttttgaatc
ccattttcca gttttttt 38 28 825 DNA Artificial Sequence Chimeric
nucleic acid 28 atg aaa aaa tat tta ttg gga ata ggt cta ata tta gcc
tta ata gca 48 Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala
Leu Ile Ala 1 5 10 15 tgt aag caa aat gtt agc agc ctt gat gaa aaa
aat agc gtt tca gta 96 Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys
Asn Ser Val Ser Val 20 25 30 gat tta cct ggt gga atg aca gtt ctt
gta agt aaa gaa aaa gac aaa 144 Asp Leu Pro Gly Gly Met Thr Val Leu
Val Ser Lys Glu Lys Asp Lys 35 40 45 gac ggt aaa tac agt cta gag
gca aca gta gac aag ctt gag ctt aaa 192 Asp Gly Lys Tyr Ser Leu Glu
Ala Thr Val Asp Lys Leu Glu Leu Lys 50 55 60 gga act tct gat aaa
aac aac ggt tct gga aca ctt gaa ggt gaa aaa 240 Gly Thr Ser Asp Lys
Asn Asn Gly Ser Gly Thr Leu Glu Gly Glu Lys 65 70 75 80 act gac aaa
agt aaa gta aaa tta aca att gct gat gac cta agt caa 288 Thr Asp Lys
Ser Lys Val Lys Leu Thr Ile Ala Asp Asp Leu Ser Gln 85 90 95 act
aaa ttt gaa att ttc aaa gaa gat gcc aaa aca tta gta tca aaa 336 Thr
Lys Phe Glu Ile Phe Lys Glu Asp Ala Lys Thr Leu Val Ser Lys 100 105
110 aaa gta acc ctt aaa gac aag tca tca aca gaa gaa aaa ttc aac gaa
384 Lys Val Thr Leu Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn Glu
115 120 125 aag ggt gaa aca tct gaa aaa aca ata gta aga gca aat gga
acc aga 432 Lys Gly Glu Thr Ser Glu Lys Thr Ile Val Arg Ala Asn Gly
Thr Arg 130 135 140 ctt gaa tac aca gac ata aaa agc gat gga tcc gga
aaa gct aaa gaa 480 Leu Glu Tyr Thr Asp Ile Lys Ser Asp Gly Ser Gly
Lys Ala Lys Glu 145 150 155 160 gtt tta aaa gac ttt act ctt gaa gga
act cta gct gct gac ggc aaa 528 Val Leu Lys Asp Phe Thr Leu Glu Gly
Thr Leu Ala Ala Asp Gly Lys 165 170 175 aca aca ttg aaa gtt aca gaa
ggc act gtt gtt tta agc aag aac att 576 Thr Thr Leu Lys Val Thr Glu
Gly Thr Val Val Leu Ser Lys Asn Ile 180 185 190 tta aaa tcc gga gaa
ata aca gtt gca ctt gat gac tct gac act act 624 Leu Lys Ser Gly Glu
Ile Thr Val Ala Leu Asp Asp Ser Asp Thr Thr 195 200 205 cag gct act
aaa aaa act gga aaa tgg gat tca aaa act tct act tta 672 Gln Ala Thr
Lys Lys Thr Gly Lys Trp Asp Ser Lys Thr Ser Thr Leu 210 215 220 aca
att agt gtt aac agc aaa aaa act aca caa ctt gtg ttt act aaa 720 Thr
Ile Ser Val Asn Ser Lys Lys Thr Thr Gln Leu Val Phe Thr Lys 225 230
235 240 caa tac aca ata act gta aaa caa tac gac tcc gca ggt acc aat
tta 768 Gln Tyr Thr Ile Thr Val Lys Gln Tyr Asp Ser Ala Gly Thr Asn
Leu 245 250 255 gaa ggc aca gca gtc gaa att aaa aca ctt gat gaa ctt
aaa aac gct 816 Glu Gly Thr Ala Val Glu Ile Lys Thr Leu Asp Glu Leu
Lys Asn Ala 260 265 270 tta aaa taa 825 Leu Lys * 29 274 PRT
Artificial Sequence Chimeric protein 29 Met Lys Lys Tyr Leu Leu Gly
Ile Gly Leu Ile Leu Ala Leu Ile Ala 1 5 10 15 Cys Lys Gln Asn Val
Ser Ser Leu Asp Glu Lys Asn Ser Val Ser Val 20 25 30 Asp Leu Pro
Gly Gly Met Thr Val Leu Val Ser Lys Glu Lys Asp Lys 35 40 45 Asp
Gly Lys Tyr Ser Leu Glu Ala Thr Val Asp Lys Leu Glu Leu Lys 50 55
60 Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Thr Leu Glu Gly Glu Lys
65 70 75 80 Thr Asp Lys Ser Lys Val Lys Leu Thr Ile Ala Asp Asp Leu
Ser Gln 85 90 95 Thr Lys Phe Glu Ile Phe Lys Glu Asp Ala Lys Thr
Leu Val Ser Lys 100 105 110 Lys Val Thr Leu Lys Asp Lys Ser Ser Thr
Glu Glu Lys Phe Asn Glu 115 120 125 Lys Gly Glu Thr Ser Glu Lys Thr
Ile Val Arg Ala Asn Gly Thr Arg 130 135 140 Leu Glu Tyr Thr Asp Ile
Lys Ser Asp Gly Ser Gly Lys Ala Lys Glu 145 150 155 160 Val Leu Lys
Asp Phe Thr Leu Glu Gly Thr Leu Ala Ala Asp Gly Lys 165 170 175 Thr
Thr Leu Lys Val Thr Glu Gly Thr Val Val Leu Ser Lys Asn Ile 180 185
190 Leu Lys Ser Gly Glu Ile Thr Val Ala Leu Asp Asp Ser Asp Thr Thr
195 200 205 Gln Ala Thr Lys Lys Thr Gly Lys Trp Asp Ser Lys Thr Ser
Thr Leu 210 215 220 Thr Ile Ser Val Asn Ser Lys Lys Thr Thr Gln Leu
Val Phe Thr Lys 225 230 235 240 Gln Tyr Thr Ile Thr Val Lys Gln Tyr
Asp Ser Ala Gly Thr Asn Leu 245 250 255 Glu Gly Thr Ala Val Glu Ile
Lys Thr Leu Asp Glu Leu Lys Asn Ala 260 265 270 Leu Lys 30 822 DNA
Artificial Sequence CDS (1)...(822) Chimeric nucleic acid 30 atg
aaa aaa tat tta ttg gga ata ggt cta ata tta gcc tta ata gca 48 Met
Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile Ala 1 5 10
15 tgc aag caa aat gtt agc agc ctt gat gaa aaa aac agc gct tca gta
96 Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Ala Ser Val
20 25 30 gat ttg cct ggt gag atg aaa gtt ctt gta agt aaa gaa aaa
gac aaa 144 Asp Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys
Asp Lys 35 40 45 gac ggt aag tac agt cta aag gca aca gta gac aag
att gag cta aaa 192 Asp Gly Lys Tyr Ser Leu Lys Ala Thr Val Asp Lys
Ile Glu Leu Lys 50 55 60 gga act tct gat aaa gac aat ggt tct gga
gtg ctt gaa ggt aca aaa 240 Gly Thr Ser Asp Lys Asp Asn Gly Ser Gly
Val Leu Glu Gly Thr Lys 65 70 75 80 gat gac aaa agt aaa gca
aaa tta aca att gct gac gat cta agt aaa 288 Asp Asp Lys Ser Lys Ala
Lys Leu Thr Ile Ala Asp Asp Leu Ser Lys 85 90 95 acc aca ttc gaa
ctt tta aaa gaa gat ggc aaa aca tta gtg tca aga 336 Thr Thr Phe Glu
Leu Leu Lys Glu Asp Gly Lys Thr Leu Val Ser Arg 100 105 110 aaa gta
agt tct aga gac aaa aca tca aca gat gaa atg ttc aat gaa 384 Lys Val
Ser Ser Arg Asp Lys Thr Ser Thr Asp Glu Met Phe Asn Glu 115 120 125
aaa ggt gaa ttg tct gca aaa acc atg aca aga gaa aat gga acc aaa 432
Lys Gly Glu Leu Ser Ala Lys Thr Met Thr Arg Glu Asn Gly Thr Lys 130
135 140 ctt gaa tat aca gaa atg aaa agc gat gga acc gga aaa gct aaa
gaa 480 Leu Glu Tyr Thr Glu Met Lys Ser Asp Gly Thr Gly Lys Ala Lys
Glu 145 150 155 160 gtt tta aaa aag ttt act ctt gaa gga aaa gta gct
aat gat aaa gta 528 Val Leu Lys Lys Phe Thr Leu Glu Gly Lys Val Ala
Asn Asp Lys Val 165 170 175 aca ttg gaa gta aaa gaa gga acc gtt act
tta agt aag gaa att gca 576 Thr Leu Glu Val Lys Glu Gly Thr Val Thr
Leu Ser Lys Glu Ile Ala 180 185 190 aaa tct gga gaa gta aca gtt gct
ctt aat gac act aac act act cag 624 Lys Ser Gly Glu Val Thr Val Ala
Leu Asn Asp Thr Asn Thr Thr Gln 195 200 205 gct act aaa aaa act ggc
gca tgg gat tca aaa act tct act tta aca 672 Ala Thr Lys Lys Thr Gly
Ala Trp Asp Ser Lys Thr Ser Thr Leu Thr 210 215 220 att agt gtt aac
agc aaa aaa act aca caa ctt gtg ttt act aaa caa 720 Ile Ser Val Asn
Ser Lys Lys Thr Thr Gln Leu Val Phe Thr Lys Gln 225 230 235 240 tac
aca ata act gta aaa caa tac gac tcc gca ggt acc aat tta gaa 768 Tyr
Thr Ile Thr Val Lys Gln Tyr Asp Ser Ala Gly Thr Asn Leu Glu 245 250
255 ggc aca gca gtc gaa att aaa aca ctt gat gaa ctt aaa aac gct tta
816 Gly Thr Ala Val Glu Ile Lys Thr Leu Asp Glu Leu Lys Asn Ala Leu
260 265 270 aaa taa 822 Lys * 31 273 PRT Artificial Sequence
Chimeric protein 31 Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu
Ala Leu Ile Ala 1 5 10 15 Cys Lys Gln Asn Val Ser Ser Leu Asp Glu
Lys Asn Ser Ala Ser Val 20 25 30 Asp Leu Pro Gly Glu Met Lys Val
Leu Val Ser Lys Glu Lys Asp Lys 35 40 45 Asp Gly Lys Tyr Ser Leu
Lys Ala Thr Val Asp Lys Ile Glu Leu Lys 50 55 60 Gly Thr Ser Asp
Lys Asp Asn Gly Ser Gly Val Leu Glu Gly Thr Lys 65 70 75 80 Asp Asp
Lys Ser Lys Ala Lys Leu Thr Ile Ala Asp Asp Leu Ser Lys 85 90 95
Thr Thr Phe Glu Leu Leu Lys Glu Asp Gly Lys Thr Leu Val Ser Arg 100
105 110 Lys Val Ser Ser Arg Asp Lys Thr Ser Thr Asp Glu Met Phe Asn
Glu 115 120 125 Lys Gly Glu Leu Ser Ala Lys Thr Met Thr Arg Glu Asn
Gly Thr Lys 130 135 140 Leu Glu Tyr Thr Glu Met Lys Ser Asp Gly Thr
Gly Lys Ala Lys Glu 145 150 155 160 Val Leu Lys Lys Phe Thr Leu Glu
Gly Lys Val Ala Asn Asp Lys Val 165 170 175 Thr Leu Glu Val Lys Glu
Gly Thr Val Thr Leu Ser Lys Glu Ile Ala 180 185 190 Lys Ser Gly Glu
Val Thr Val Ala Leu Asn Asp Thr Asn Thr Thr Gln 195 200 205 Ala Thr
Lys Lys Thr Gly Ala Trp Asp Ser Lys Thr Ser Thr Leu Thr 210 215 220
Ile Ser Val Asn Ser Lys Lys Thr Thr Gln Leu Val Phe Thr Lys Gln 225
230 235 240 Tyr Thr Ile Thr Val Lys Gln Tyr Asp Ser Ala Gly Thr Asn
Leu Glu 245 250 255 Gly Thr Ala Val Glu Ile Lys Thr Leu Asp Glu Leu
Lys Asn Ala Leu 260 265 270 Lys 32 822 DNA Artificial Sequence
Chimeric nucleic acid 32 atg aaa aaa tat tta ttg gga ata ggt cta
ata tta gcc tta ata gca 48 Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu
Ile Leu Ala Leu Ile Ala 1 5 10 15 tgt aag caa aat gtt agc agc ctt
gac gag aaa aac agc gtt tca gta 96 Cys Lys Gln Asn Val Ser Ser Leu
Asp Glu Lys Asn Ser Val Ser Val 20 25 30 gat ttg cct ggt gaa atg
aaa gtt ctt gta agc aaa gaa aaa aac aaa 144 Asp Leu Pro Gly Glu Met
Lys Val Leu Val Ser Lys Glu Lys Asn Lys 35 40 45 gac ggc aag tac
gat cta att gca aca gta gac aag ctt gag ctt aaa 192 Asp Gly Lys Tyr
Asp Leu Ile Ala Thr Val Asp Lys Leu Glu Leu Lys 50 55 60 gga act
tct gat aaa aac aat gga tct gga gta ctt gaa ggc gta aaa 240 Gly Thr
Ser Asp Lys Asn Asn Gly Ser Gly Val Leu Glu Gly Val Lys 65 70 75 80
gct gac aaa agt aaa gta aaa tta aca att tct gac gat cta ggt caa 288
Ala Asp Lys Ser Lys Val Lys Leu Thr Ile Ser Asp Asp Leu Gly Gln 85
90 95 acc aca ctt gaa gtt ttc aaa gaa gat ggc aaa aca cta gta tca
aaa 336 Thr Thr Leu Glu Val Phe Lys Glu Asp Gly Lys Thr Leu Val Ser
Lys 100 105 110 aaa gta act tcc aaa gac aag tca tca aca gaa gaa aaa
ttc aat gaa 384 Lys Val Thr Ser Lys Asp Lys Ser Ser Thr Glu Glu Lys
Phe Asn Glu 115 120 125 aaa ggt gaa gta tct gaa aaa ata ata aca aga
gca gac gga acc aga 432 Lys Gly Glu Val Ser Glu Lys Ile Ile Thr Arg
Ala Asp Gly Thr Arg 130 135 140 ctt gaa tac aca gga att aaa agc gat
gga tct gga aaa gct aaa gag 480 Leu Glu Tyr Thr Gly Ile Lys Ser Asp
Gly Ser Gly Lys Ala Lys Glu 145 150 155 160 gtt tta aaa ggc tat gtt
ctt gaa gga act cta act gct gaa aaa aca 528 Val Leu Lys Gly Tyr Val
Leu Glu Gly Thr Leu Thr Ala Glu Lys Thr 165 170 175 aca ttg gtg gtt
aaa gaa gga act gtt act tta agc aaa aat att tca 576 Thr Leu Val Val
Lys Glu Gly Thr Val Thr Leu Ser Lys Asn Ile Ser 180 185 190 aaa tct
ggg gaa gtt tca gtt gaa ctt aat gac act gac agt agt gct 624 Lys Ser
Gly Glu Val Ser Val Glu Leu Asn Asp Thr Asp Ser Ser Ala 195 200 205
gct act aaa aaa act gca gct tgg aat tca aaa act tcc act tta aca 672
Ala Thr Lys Lys Thr Ala Ala Trp Asn Ser Lys Thr Ser Thr Leu Thr 210
215 220 att agt gtg aat agc caa aaa acc aaa aac ctt gta ttc aca aaa
gaa 720 Ile Ser Val Asn Ser Gln Lys Thr Lys Asn Leu Val Phe Thr Lys
Glu 225 230 235 240 gac aca ata aca gta caa aaa tac gac tca gca ggc
acc aat cta gaa 768 Asp Thr Ile Thr Val Gln Lys Tyr Asp Ser Ala Gly
Thr Asn Leu Glu 245 250 255 ggc aaa gca gtc gaa att aca aca ctt aaa
gaa ctt aaa aac gct tta 816 Gly Lys Ala Val Glu Ile Thr Thr Leu Lys
Glu Leu Lys Asn Ala Leu 260 265 270 aaa taa 822 Lys * 33 273 PRT
Artificial Sequence Chimeric protein 33 Met Lys Lys Tyr Leu Leu Gly
Ile Gly Leu Ile Leu Ala Leu Ile Ala 1 5 10 15 Cys Lys Gln Asn Val
Ser Ser Leu Asp Glu Lys Asn Ser Val Ser Val 20 25 30 Asp Leu Pro
Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys Asn Lys 35 40 45 Asp
Gly Lys Tyr Asp Leu Ile Ala Thr Val Asp Lys Leu Glu Leu Lys 50 55
60 Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Val Leu Glu Gly Val Lys
65 70 75 80 Ala Asp Lys Ser Lys Val Lys Leu Thr Ile Ser Asp Asp Leu
Gly Gln 85 90 95 Thr Thr Leu Glu Val Phe Lys Glu Asp Gly Lys Thr
Leu Val Ser Lys 100 105 110 Lys Val Thr Ser Lys Asp Lys Ser Ser Thr
Glu Glu Lys Phe Asn Glu 115 120 125 Lys Gly Glu Val Ser Glu Lys Ile
Ile Thr Arg Ala Asp Gly Thr Arg 130 135 140 Leu Glu Tyr Thr Gly Ile
Lys Ser Asp Gly Ser Gly Lys Ala Lys Glu 145 150 155 160 Val Leu Lys
Gly Tyr Val Leu Glu Gly Thr Leu Thr Ala Glu Lys Thr 165 170 175 Thr
Leu Val Val Lys Glu Gly Thr Val Thr Leu Ser Lys Asn Ile Ser 180 185
190 Lys Ser Gly Glu Val Ser Val Glu Leu Asn Asp Thr Asp Ser Ser Ala
195 200 205 Ala Thr Lys Lys Thr Ala Ala Trp Asn Ser Lys Thr Ser Thr
Leu Thr 210 215 220 Ile Ser Val Asn Ser Gln Lys Thr Lys Asn Leu Val
Phe Thr Lys Glu 225 230 235 240 Asp Thr Ile Thr Val Gln Lys Tyr Asp
Ser Ala Gly Thr Asn Leu Glu 245 250 255 Gly Lys Ala Val Glu Ile Thr
Thr Leu Lys Glu Leu Lys Asn Ala Leu 260 265 270 Lys 34 819 DNA
Artificial Sequence Chimeric nucleic acid 34 atg aaa aaa tat tta
ttg gga ata ggt cta ata tta gcc tta ata gca 48 Met Lys Lys Tyr Leu
Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile Ala 1 5 10 15 tgt aag caa
aat gtt agc agc ctt gac gag aaa aac agc gtt tca gta 96 Cys Lys Gln
Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val Ser Val 20 25 30 gat
ttg cct ggt gaa atg aaa gtt ctt gta agc aaa gaa aaa aac aaa 144 Asp
Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys Asn Lys 35 40
45 gac ggc aag tac gat cta att gca aca gta gac aag ctt gag ctt aaa
192 Asp Gly Lys Tyr Asp Leu Ile Ala Thr Val Asp Lys Leu Glu Leu Lys
50 55 60 gga act tct gat aaa aac aat gga tct gga gta ctt gaa ggc
gta aaa 240 Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Val Leu Glu Gly
Val Lys 65 70 75 80 gct gac aaa agt aaa gta aaa tta aca att tct gac
gat cta ggt caa 288 Ala Asp Lys Ser Lys Val Lys Leu Thr Ile Ser Asp
Asp Leu Gly Gln 85 90 95 acc aca ctt gaa gtt ttc aaa gaa gat ggc
aaa aca cta gta tca aaa 336 Thr Thr Leu Glu Val Phe Lys Glu Asp Gly
Lys Thr Leu Val Ser Lys 100 105 110 aaa gta act tcc aaa gac aag tca
tca aca gaa gaa aaa ttc aat gaa 384 Lys Val Thr Ser Lys Asp Lys Ser
Ser Thr Glu Glu Lys Phe Asn Glu 115 120 125 aaa ggt gaa gta tct gaa
aaa ata ata aca aga gca gac gga acc aga 432 Lys Gly Glu Val Ser Glu
Lys Ile Ile Thr Arg Ala Asp Gly Thr Arg 130 135 140 ctt gaa tac aca
gga att aaa agc gat gga tct gga aaa gct aaa gag 480 Leu Glu Tyr Thr
Gly Ile Lys Ser Asp Gly Ser Gly Lys Ala Lys Glu 145 150 155 160 gtt
tta aaa ggc tat gtt ctt gaa gga act cta act gct gaa aaa aca 528 Val
Leu Lys Gly Tyr Val Leu Glu Gly Thr Leu Thr Ala Glu Lys Thr 165 170
175 aca ttg gtg gtt aaa gaa gga act gtt act tta agc aaa aat att tca
576 Thr Leu Val Val Lys Glu Gly Thr Val Thr Leu Ser Lys Asn Ile Ser
180 185 190 aaa tct ggg gaa gtt tca gtt gaa ctt aat gac act gac agt
agt gct 624 Lys Ser Gly Glu Val Ser Val Glu Leu Asn Asp Thr Asp Ser
Ser Ala 195 200 205 gct act aaa aaa act gca gct tgg aat gca ggc act
tca act tta aca 672 Ala Thr Lys Lys Thr Ala Ala Trp Asn Ala Gly Thr
Ser Thr Leu Thr 210 215 220 att act gta aac aac aaa aaa act aaa gcc
ctt gta ttt aca aaa caa 720 Ile Thr Val Asn Asn Lys Lys Thr Lys Ala
Leu Val Phe Thr Lys Gln 225 230 235 240 gac aca att aca tca caa aaa
tac gac tca gca gga acc aac ttg gaa 768 Asp Thr Ile Thr Ser Gln Lys
Tyr Asp Ser Ala Gly Thr Asn Leu Glu 245 250 255 ggc aca gca gtc gaa
att aaa aca ctt gat gaa ctt aaa aac gct tta 816 Gly Thr Ala Val Glu
Ile Lys Thr Leu Asp Glu Leu Lys Asn Ala Leu 260 265 270 aga 819 Arg
35 273 PRT Artificial Sequence Chimeric protein 35 Met Lys Lys Tyr
Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile Ala 1 5 10 15 Cys Lys
Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val Ser Val 20 25 30
Asp Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys Asn Lys 35
40 45 Asp Gly Lys Tyr Asp Leu Ile Ala Thr Val Asp Lys Leu Glu Leu
Lys 50 55 60 Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Val Leu Glu
Gly Val Lys 65 70 75 80 Ala Asp Lys Ser Lys Val Lys Leu Thr Ile Ser
Asp Asp Leu Gly Gln 85 90 95 Thr Thr Leu Glu Val Phe Lys Glu Asp
Gly Lys Thr Leu Val Ser Lys 100 105 110 Lys Val Thr Ser Lys Asp Lys
Ser Ser Thr Glu Glu Lys Phe Asn Glu 115 120 125 Lys Gly Glu Val Ser
Glu Lys Ile Ile Thr Arg Ala Asp Gly Thr Arg 130 135 140 Leu Glu Tyr
Thr Gly Ile Lys Ser Asp Gly Ser Gly Lys Ala Lys Glu 145 150 155 160
Val Leu Lys Gly Tyr Val Leu Glu Gly Thr Leu Thr Ala Glu Lys Thr 165
170 175 Thr Leu Val Val Lys Glu Gly Thr Val Thr Leu Ser Lys Asn Ile
Ser 180 185 190 Lys Ser Gly Glu Val Ser Val Glu Leu Asn Asp Thr Asp
Ser Ser Ala 195 200 205 Ala Thr Lys Lys Thr Ala Ala Trp Asn Ala Gly
Thr Ser Thr Leu Thr 210 215 220 Ile Thr Val Asn Asn Lys Lys Thr Lys
Ala Leu Val Phe Thr Lys Gln 225 230 235 240 Asp Thr Ile Thr Ser Gln
Lys Tyr Asp Ser Ala Gly Thr Asn Leu Glu 245 250 255 Gly Thr Ala Val
Glu Ile Lys Thr Leu Asp Glu Leu Lys Asn Ala Leu 260 265 270 Arg 36
822 DNA Artificial Sequence Chimeric nucleic acid 36 atg aaa aaa
tat tta ttg gga ata ggt cta ata tta gcc tta ata gca 48 Met Lys Lys
Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile Ala 1 5 10 15 tgt
aag caa aat gtt agc agc ctt gat gaa aaa aat agc gtt tca gta 96 Cys
Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val Ser Val 20 25
30 gat tta cct ggt gga atg aca gtt ctt gta agt aaa gaa aaa gac aaa
144 Asp Leu Pro Gly Gly Met Thr Val Leu Val Ser Lys Glu Lys Asp Lys
35 40 45 gac ggt aaa tac agt cta gag gca aca gta gac aag ctt gag
ctt aaa 192 Asp Gly Lys Tyr Ser Leu Glu Ala Thr Val Asp Lys Leu Glu
Leu Lys 50 55 60 gga act tct gat aaa aac aac ggt tct gga aca ctt
gaa ggt gaa aaa 240 Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Thr Leu
Glu Gly Glu Lys 65 70 75 80 act gac aaa agt aaa gta aaa tta aca att
gct gat gac cta agt caa 288 Thr Asp Lys Ser Lys Val Lys Leu Thr Ile
Ala Asp Asp Leu Ser Gln 85 90 95 act aaa ttt gaa att ttc aaa gaa
gat gcc aaa aca tta gta tca aaa 336 Thr Lys Phe Glu Ile Phe Lys Glu
Asp Ala Lys Thr Leu Val Ser Lys 100 105 110 aaa gta acc ctt aaa gac
aag tca tca aca gaa gaa aaa ttc aac gaa 384 Lys Val Thr Leu Lys Asp
Lys Ser Ser Thr Glu Glu Lys Phe Asn Glu 115 120 125 aag ggt gaa aca
tct gaa aaa aca ata gta aga gca aat gga acc aga 432 Lys Gly Glu Thr
Ser Glu Lys Thr Ile Val Arg Ala Asn Gly Thr Arg 130 135 140 ctt gaa
tac aca gac ata aaa agc gat gga tcc gga aaa gct aaa gaa 480 Leu Glu
Tyr Thr Asp Ile Lys Ser Asp Gly Ser Gly Lys Ala Lys Glu 145 150 155
160 gtt tta aaa gac ttt act ctt gaa gga act cta gct gct gac ggc aaa
528 Val Leu Lys Asp Phe Thr Leu Glu Gly Thr Leu Ala Ala Asp Gly Lys
165 170 175 aca aca ttg aaa gtt aca gaa ggc act gtt gtt tta agc aag
att tca 576 Thr Thr Leu Lys Val Thr Glu Gly Thr Val Val Leu Ser Lys
Ile Ser 180 185 190 aaa tct ggg gaa gtt tca gtt gaa ctt aat gac act
gac agt agt gct 624 Lys Ser Gly Glu Val Ser Val Glu Leu Asn Asp Thr
Asp Ser Ser Ala 195 200 205 gct act aaa aaa act gca gct tgg aat tca
aaa act tcc act tta aca 672 Ala Thr Lys Lys Thr Ala Ala Trp Asn Ser
Lys Thr Ser Thr Leu Thr 210 215 220 att agt gtg aat agc caa aaa acc
aaa aac ctt gta ttc aca aaa gaa 720 Ile Ser Val Asn Ser Gln Lys
Thr Lys Asn Leu Val Phe Thr Lys Glu 225 230 235 240 gac aca ata aca
gta caa aaa tac gac tca gca ggc acc aat cta gaa 768 Asp Thr Ile Thr
Val Gln Lys Tyr Asp Ser Ala Gly Thr Asn Leu Glu 245 250 255 ggc aaa
gca gtc gaa att aca aca ctt aaa gaa ctt aaa aac gct tta 816 Gly Lys
Ala Val Glu Ile Thr Thr Leu Lys Glu Leu Lys Asn Ala Leu 260 265 270
aaa taa 822 Lys * 37 273 PRT Artificial Sequence Chimeric protein
37 Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile Ala
1 5 10 15 Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val
Ser Val 20 25 30 Asp Leu Pro Gly Gly Met Thr Val Leu Val Ser Lys
Glu Lys Asp Lys 35 40 45 Asp Gly Lys Tyr Ser Leu Glu Ala Thr Val
Asp Lys Leu Glu Leu Lys 50 55 60 Gly Thr Ser Asp Lys Asn Asn Gly
Ser Gly Thr Leu Glu Gly Glu Lys 65 70 75 80 Thr Asp Lys Ser Lys Val
Lys Leu Thr Ile Ala Asp Asp Leu Ser Gln 85 90 95 Thr Lys Phe Glu
Ile Phe Lys Glu Asp Ala Lys Thr Leu Val Ser Lys 100 105 110 Lys Val
Thr Leu Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn Glu 115 120 125
Lys Gly Glu Thr Ser Glu Lys Thr Ile Val Arg Ala Asn Gly Thr Arg 130
135 140 Leu Glu Tyr Thr Asp Ile Lys Ser Asp Gly Ser Gly Lys Ala Lys
Glu 145 150 155 160 Val Leu Lys Asp Phe Thr Leu Glu Gly Thr Leu Ala
Ala Asp Gly Lys 165 170 175 Thr Thr Leu Lys Val Thr Glu Gly Thr Val
Val Leu Ser Lys Ile Ser 180 185 190 Lys Ser Gly Glu Val Ser Val Glu
Leu Asn Asp Thr Asp Ser Ser Ala 195 200 205 Ala Thr Lys Lys Thr Ala
Ala Trp Asn Ser Lys Thr Ser Thr Leu Thr 210 215 220 Ile Ser Val Asn
Ser Gln Lys Thr Lys Asn Leu Val Phe Thr Lys Glu 225 230 235 240 Asp
Thr Ile Thr Val Gln Lys Tyr Asp Ser Ala Gly Thr Asn Leu Glu 245 250
255 Gly Lys Ala Val Glu Ile Thr Thr Leu Lys Glu Leu Lys Asn Ala Leu
260 265 270 Lys 38 822 DNA Artificial Sequence Chimeric nucleic
acid 38 atg aaa aaa tat tta ttg gga ata ggt cta ata tta gcc tta ata
gca 48 Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile
Ala 1 5 10 15 tgt aag caa aat gtt agc agc ctt gat gaa aaa aat agc
gtt tca gta 96 Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser
Val Ser Val 20 25 30 gat tta cct ggt gga atg aca gtt ctt gta agt
aaa gaa aaa gac aaa 144 Asp Leu Pro Gly Gly Met Thr Val Leu Val Ser
Lys Glu Lys Asp Lys 35 40 45 gac ggt aaa tac agt cta gag gca aca
gta gac aag ctt gag ctt aaa 192 Asp Gly Lys Tyr Ser Leu Glu Ala Thr
Val Asp Lys Leu Glu Leu Lys 50 55 60 gga act tct gat aaa aac aac
ggt tct gga aca ctt gaa ggt gaa aaa 240 Gly Thr Ser Asp Lys Asn Asn
Gly Ser Gly Thr Leu Glu Gly Glu Lys 65 70 75 80 act gac aaa agt aaa
gta aaa tta aca att gct gat gac cta agt caa 288 Thr Asp Lys Ser Lys
Val Lys Leu Thr Ile Ala Asp Asp Leu Ser Gln 85 90 95 act aaa ttt
gaa att ttc aaa gaa gat gcc aaa aca tta gta tca aaa 336 Thr Lys Phe
Glu Ile Phe Lys Glu Asp Ala Lys Thr Leu Val Ser Lys 100 105 110 aaa
gta acc ctt aaa gac aag tca tca aca gaa gaa aaa ttc aac gaa 384 Lys
Val Thr Leu Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn Glu 115 120
125 aag ggt gaa aca tct gaa aaa aca ata gta aga gca aat gga acc aga
432 Lys Gly Glu Thr Ser Glu Lys Thr Ile Val Arg Ala Asn Gly Thr Arg
130 135 140 ctt gaa tac aca gac ata aaa agc gat gga tcc gga aaa gct
aaa gaa 480 Leu Glu Tyr Thr Asp Ile Lys Ser Asp Gly Ser Gly Lys Ala
Lys Glu 145 150 155 160 gtt tta aaa gac ttt act ctt gaa gga act cta
gct gct gac ggc aaa 528 Val Leu Lys Asp Phe Thr Leu Glu Gly Thr Leu
Ala Ala Asp Gly Lys 165 170 175 aca aca ttg aaa gtt aca gaa ggc act
gtt gtt tta agc aag att tca 576 Thr Thr Leu Lys Val Thr Glu Gly Thr
Val Val Leu Ser Lys Ile Ser 180 185 190 aaa tct ggg gaa gtt tca gtt
gaa ctt aat gac act gac agt agt gct 624 Lys Ser Gly Glu Val Ser Val
Glu Leu Asn Asp Thr Asp Ser Ser Ala 195 200 205 gct act aaa aaa act
gca gct tgg aat tca aaa act tcc act tta aca 672 Ala Thr Lys Lys Thr
Ala Ala Trp Asn Ser Lys Thr Ser Thr Leu Thr 210 215 220 att agt gtg
aat agc caa aaa acc aaa aac ctt gta ttc aca aaa gaa 720 Ile Ser Val
Asn Ser Gln Lys Thr Lys Asn Leu Val Phe Thr Lys Glu 225 230 235 240
gac aca ata aca gta caa aaa tac gac tca gca ggc acc aat cta gaa 768
Asp Thr Ile Thr Val Gln Lys Tyr Asp Ser Ala Gly Thr Asn Leu Glu 245
250 255 ggc aaa gca gtc gaa att aca aca ctt aaa gaa ctt aaa aac gct
tta 816 Gly Lys Ala Val Glu Ile Thr Thr Leu Lys Glu Leu Lys Asn Ala
Leu 260 265 270 aaa taa 822 Lys * 39 273 PRT Artificial Sequence
Chimeric protein 39 Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu
Ala Leu Ile Ala 1 5 10 15 Cys Lys Gln Asn Val Ser Ser Leu Asp Glu
Lys Asn Ser Val Ser Val 20 25 30 Asp Leu Pro Gly Gly Met Thr Val
Leu Val Ser Lys Glu Lys Asp Lys 35 40 45 Asp Gly Lys Tyr Ser Leu
Glu Ala Thr Val Asp Lys Leu Glu Leu Lys 50 55 60 Gly Thr Ser Asp
Lys Asn Asn Gly Ser Gly Thr Leu Glu Gly Glu Lys 65 70 75 80 Thr Asp
Lys Ser Lys Val Lys Leu Thr Ile Ala Asp Asp Leu Ser Gln 85 90 95
Thr Lys Phe Glu Ile Phe Lys Glu Asp Ala Lys Thr Leu Val Ser Lys 100
105 110 Lys Val Thr Leu Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn
Glu 115 120 125 Lys Gly Glu Thr Ser Glu Lys Thr Ile Val Arg Ala Asn
Gly Thr Arg 130 135 140 Leu Glu Tyr Thr Asp Ile Lys Ser Asp Gly Ser
Gly Lys Ala Lys Glu 145 150 155 160 Val Leu Lys Asp Phe Thr Leu Glu
Gly Thr Leu Ala Ala Asp Gly Lys 165 170 175 Thr Thr Leu Lys Val Thr
Glu Gly Thr Val Val Leu Ser Lys Ile Ser 180 185 190 Lys Ser Gly Glu
Val Ser Val Glu Leu Asn Asp Thr Asp Ser Ser Ala 195 200 205 Ala Thr
Lys Lys Thr Ala Ala Trp Asn Ser Lys Thr Ser Thr Leu Thr 210 215 220
Ile Ser Val Asn Ser Gln Lys Thr Lys Asn Leu Val Phe Thr Lys Glu 225
230 235 240 Asp Thr Ile Thr Val Gln Lys Tyr Asp Ser Ala Gly Thr Asn
Leu Glu 245 250 255 Gly Lys Ala Val Glu Ile Thr Thr Leu Lys Glu Leu
Lys Asn Ala Leu 260 265 270 Lys 40 822 DNA Artificial Sequence
Chimeric nucleic acid 40 atg aaa aaa tat tta ttg gga ata ggt cta
ata tta gcc tta ata gca 48 Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu
Ile Leu Ala Leu Ile Ala 1 5 10 15 tgt aag caa aat gtt agc agc ctt
gac gag aaa aac agc gtt tca gta 96 Cys Lys Gln Asn Val Ser Ser Leu
Asp Glu Lys Asn Ser Val Ser Val 20 25 30 gat ttg cct ggt gaa atg
aaa gtt ctt gta agc aaa gaa aaa aac aaa 144 Asp Leu Pro Gly Glu Met
Lys Val Leu Val Ser Lys Glu Lys Asn Lys 35 40 45 gac ggc aag tac
gat cta att gca aca gta gac aag ctt gag ctt aaa 192 Asp Gly Lys Tyr
Asp Leu Ile Ala Thr Val Asp Lys Leu Glu Leu Lys 50 55 60 gga act
tct gat aaa aac aat gga tct gga gta ctt gaa ggc gta aaa 240 Gly Thr
Ser Asp Lys Asn Asn Gly Ser Gly Val Leu Glu Gly Val Lys 65 70 75 80
gct gac aaa agt aaa gta aaa tta aca att tct gac gat cta ggt caa 288
Ala Asp Lys Ser Lys Val Lys Leu Thr Ile Ser Asp Asp Leu Gly Gln 85
90 95 acc aca ctt gaa gtt ttc aaa gaa gat ggc aaa aca cta gta tca
aaa 336 Thr Thr Leu Glu Val Phe Lys Glu Asp Gly Lys Thr Leu Val Ser
Lys 100 105 110 aaa gta act tcc aaa gac aag tca tca aca gaa gaa aaa
ttc aat gaa 384 Lys Val Thr Ser Lys Asp Lys Ser Ser Thr Glu Glu Lys
Phe Asn Glu 115 120 125 aaa ggt gaa gta tct gaa aaa ata ata aca aga
gca gac gga acc aga 432 Lys Gly Glu Val Ser Glu Lys Ile Ile Thr Arg
Ala Asp Gly Thr Arg 130 135 140 ctt gaa tac aca gga att aaa agc gat
gga tct gga aaa gct aaa gag 480 Leu Glu Tyr Thr Gly Ile Lys Ser Asp
Gly Ser Gly Lys Ala Lys Glu 145 150 155 160 gtt tta aaa ggc tat gtt
ctt gaa gga act cta act gct gaa aaa aca 528 Val Leu Lys Gly Tyr Val
Leu Glu Gly Thr Leu Thr Ala Glu Lys Thr 165 170 175 aca ttg gtg gtt
aaa gaa gga act gtt act tta agc aaa aat att tca 576 Thr Leu Val Val
Lys Glu Gly Thr Val Thr Leu Ser Lys Asn Ile Ser 180 185 190 aaa tct
ggg gaa gtt tca gtt gaa ctt aat gac act gac agt agt gct 624 Lys Ser
Gly Glu Val Ser Val Glu Leu Asn Asp Thr Asp Ser Ser Ala 195 200 205
gct act aaa aaa act gca gct tgg aat gac agt act agc act tta aca 672
Ala Thr Lys Lys Thr Ala Ala Trp Asn Asp Ser Thr Ser Thr Leu Thr 210
215 220 att agt gct gac agc aaa aaa act aaa gat ttg gtg ttc tta aca
gat 720 Ile Ser Ala Asp Ser Lys Lys Thr Lys Asp Leu Val Phe Leu Thr
Asp 225 230 235 240 ggt aca att aca gta caa caa tac aac aca gct gga
acc agc cta gaa 768 Gly Thr Ile Thr Val Gln Gln Tyr Asn Thr Ala Gly
Thr Ser Leu Glu 245 250 255 gga tca gca agt gaa att aaa aat ctt tca
gag ctt aaa aac gct tta 816 Gly Ser Ala Ser Glu Ile Lys Asn Leu Ser
Glu Leu Lys Asn Ala Leu 260 265 270 aaa taa 822 Lys * 41 273 PRT
Artificial Sequence Chimeric protein 41 Met Lys Lys Tyr Leu Leu Gly
Ile Gly Leu Ile Leu Ala Leu Ile Ala 1 5 10 15 Cys Lys Gln Asn Val
Ser Ser Leu Asp Glu Lys Asn Ser Val Ser Val 20 25 30 Asp Leu Pro
Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys Asn Lys 35 40 45 Asp
Gly Lys Tyr Asp Leu Ile Ala Thr Val Asp Lys Leu Glu Leu Lys 50 55
60 Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Val Leu Glu Gly Val Lys
65 70 75 80 Ala Asp Lys Ser Lys Val Lys Leu Thr Ile Ser Asp Asp Leu
Gly Gln 85 90 95 Thr Thr Leu Glu Val Phe Lys Glu Asp Gly Lys Thr
Leu Val Ser Lys 100 105 110 Lys Val Thr Ser Lys Asp Lys Ser Ser Thr
Glu Glu Lys Phe Asn Glu 115 120 125 Lys Gly Glu Val Ser Glu Lys Ile
Ile Thr Arg Ala Asp Gly Thr Arg 130 135 140 Leu Glu Tyr Thr Gly Ile
Lys Ser Asp Gly Ser Gly Lys Ala Lys Glu 145 150 155 160 Val Leu Lys
Gly Tyr Val Leu Glu Gly Thr Leu Thr Ala Glu Lys Thr 165 170 175 Thr
Leu Val Val Lys Glu Gly Thr Val Thr Leu Ser Lys Asn Ile Ser 180 185
190 Lys Ser Gly Glu Val Ser Val Glu Leu Asn Asp Thr Asp Ser Ser Ala
195 200 205 Ala Thr Lys Lys Thr Ala Ala Trp Asn Asp Ser Thr Ser Thr
Leu Thr 210 215 220 Ile Ser Ala Asp Ser Lys Lys Thr Lys Asp Leu Val
Phe Leu Thr Asp 225 230 235 240 Gly Thr Ile Thr Val Gln Gln Tyr Asn
Thr Ala Gly Thr Ser Leu Glu 245 250 255 Gly Ser Ala Ser Glu Ile Lys
Asn Leu Ser Glu Leu Lys Asn Ala Leu 260 265 270 Lys 42 822 DNA
Borrelia burgdorferi 42 atgaaaaaat atttattggg aataggtcta atattagcct
taatagcatg taagcaaaat 60 gttagcagcc ttgacgagaa aaacagcgtt
tcagtagatt tgcctggtga aatgaaagtt 120 cttgtaagca aagaaaaaaa
caaagacggc aagtacgatc taattgcaac agtagacaag 180 cttgagctta
aaggaacttc tgataaaaac aatggatctg gagtacttga aggcgtaaaa 240
gctgacaaaa gtaaagtaaa attaacaatt tctgacgatc taggtcaaac cacacttgaa
300 gttttcaaag aagatggcaa aacactagta tcaaaaaaag taacttccaa
agacaagtca 360 tcaacagaag aaaaattcaa tgaaaaaggt gaagtatctg
aaaaaataat aacaagagca 420 gacggaacca gacttgaata cacaggaatt
aaaagcgatg gatctggaaa agctaaagag 480 gttttaaaag gctatgttct
tgaaggaact ctaactgctg aaaaaacaac attggtggtt 540 aaagaaggaa
ctgttacttt aagcaaaaat atttcaaaat ctggggaagt ttcagttgaa 600
cttaatgaca ctgacagtag tgctgctact aaaaaaactg cagcttggaa ttcaggcact
660 tcaactttaa caattactgt aaacagtaaa aaaactaaag accttgtgtt
tacaaaagaa 720 aacacaatta cagtacaaca atacgactca aatggcacca
aattagaggg gtcagcagtt 780 gaaattacaa aacttgatga aattaaaaac
gctttaaaat aa 822 43 822 DNA Borrelia burgdorferi 43 atgaaaaaat
atttattggg aataggtcta atattagcct taatagcatg taagcaaaat 60
gttagcagcc ttgacgagaa aaacagcgtt tcagtagatt tgcctggtga aatgaacgtt
120 cttgtaagca aagaaaaaaa caaagacggc aagtacgatc taattgcaac
agtagacaag 180 cttgagctta aaggaacttc tgataaaaac aatggatctg
gagtacttga aggcgtaaaa 240 gctgacaaaa gtaaagtaaa attaacaatt
tctgacgatc taggtcaaac cacacttgaa 300 gttttcaaag aagatggcaa
aacactagta tcaaaaaaag taacttccaa agacaagtca 360 tcaacagaag
aaaaattcaa tgaaaaaggt gaagtatctg aaaaaataat aacaagagca 420
gacggaacca gacttgaata cacagaaatt aaaagcgatg gatctggaaa agctaaagag
480 gttttaaaag gctatgttct tgaaggaact ctaactgctg aaaaaacaac
attggtggtt 540 aaagaaggaa ctgttacttt aagcaaaaat atttcaaaat
ctggggaagt ttcagttgaa 600 cttaatgaca ctgacagtag tgctgctact
aaaaaaactg cagcttggaa ttcaggcact 660 tcaactttaa caattactgt
aaacagtaaa aaaactaaag accttgtgtt tacaaaagaa 720 aacacaatta
cagtacaaca atacgactca aatggcacca aattagaggg gtcagcagtt 780
gaaattacaa aacttgatga aattaaaaac gctttaaaat aa 822 44 822 DNA
Borrelia burgdorferi 44 atgaaaaaat atttattggg aataggtcta atattagcct
taatagcatg taagcaaaat 60 gttagcagcc ttgacgagaa aaacagcgtt
tcagtagatt tgcctggtga aatgaacgtt 120 cttgtaagca aagaaaaaaa
caaagacggc aagtacgatc taattgcaac agtagacaag 180 cttgagctta
aaggaacttc tgataaaaac aatggatctg gagtacttga aggcgtaaaa 240
gctgacaaaa gtaaagtaaa attaacaatt tctgacgatc taggtcaaac cacacttgaa
300 gttttcaaag aagatggcaa aacactagta tcaaaaaaag taacttccaa
agacaagtca 360 tcaacagaag aaaaattcaa tgaaaaaggt gaagtatctg
aaaaaataat aacaagagca 420 gacggaacca gacttgaata cacagaaatt
aaaagcgatg gatctggaaa agctaaagag 480 gttttaaaaa gctatgttct
tgaaggaact ttaactgctg aaaaaacaac attggtggtt 540 aaagaaggaa
ctgttacttt aagcaaaaat atttcaaaat ctggggaagt ttcagttgaa 600
cttaatgaca ctgacagtag tgctgctact aaaaaaactg cagcttggaa ttcaggcact
660 tcaactttaa caattactgt aaacagtaaa aaaactaaag accttgtgtt
tacaaaagaa 720 aacacaatta cagtacaaca atacgactca aatggcacca
aattagaggg gtcagcagtt 780 gaaattacaa aacttgatga aattaaaaac
gctttaaaat aa 822 45 821 DNA Borrelia burgdorferi 45 atgaaaaaat
atttattggg aataggtcta atattagcct taatagcatg taagcaaaat 60
gttagcagcc ttgatgagaa aaacagcgtt tcagtagatt tacctggtga aatgaaagtt
120 cttgtaagca aagaaaaaga caaagatggt aaatacagtc taatggcaac
agtagacaag 180 ctagagctta aaggaacttc tgataaaagc aacggttctg
gaacacttga aggtgaaaaa 240 tctgacaaaa gtaaagcaaa attaacaatt
tctgaagatc taagtaaaac cacatttgaa 300 attttcaaag aagatggcaa
aacattagta tcaaaaaaag taaattctaa agataagtca 360 tcaatagaag
aaaaattcaa cgcaaaaggt gaattatctg aaaaaacaat actaagagca 420
aacggaacca ggcttgaata cacagaaata aaaagcgatg gaaccggaaa agctaaagaa
480 gctttaaaag actttgctct tgaaggaact ctagctgccg acaaaacaac
attgaaagtt 540 acagaaggca ctgttgtttt aagcaaacac attccaaact
ctggagaaat aacagttgag 600 cttaatgact ctaactctac tcaggctact
aaaaaaactg gaaaatggga ttcaaatact 660 tccactttaa caattagtgt
gaatagcaaa aaaactaaaa acattgtatt tacaaaagaa 720 gacacaataa
cagtacaaaa atacgactca gcaggcacca atctagaagg caacgcagtc 780
gaaattaaaa cacttgatga acttaaaaac gctttaaaat a 821 46 821 DNA
Borrelia burgdorferi 46 atgaaaaaat atttattggg aataggtcta atattagcct
taatagcatg taagcaaaat 60 gttagcagcc ttgatgaaaa aaatagcgtt
tcagtagatt tacctggtgg aatgaaagtt 120 cttgtaagta aagaaaaaga
caaagatggt aaatacagtc taatggcaac agtagaaaag 180 cttgagctta
aaggaacttc tgataaaaac aacggttctg gaacacttga aggtgaaaaa 240
actgacaaaa gtaaagtaaa attaacaatt gctgaggatc taagtaaaac
cacatttgaa
300 atcttcaaag aagatggcaa aacattagta tcgaaaaaag taacccttaa
agacaagtca 360 tcaacagaag aaaaattcaa cgaaaagggt gaaatatctg
aaaaaacaat agtaagagca 420 aatggaacca gacttgaata cacagacata
aaaagcgata aaaccggaaa agctaaagaa 480 gttttaaaag actttactct
tgaaggaact ctagctgctg acggcaaaac aacattgaaa 540 gttacagagg
gcactgttac tttaagcaag aacatttcaa aatccggaga aataacagtt 600
gcacttgatg acactgactc tagcggcaat aaaaaatccg gaacatggga ttcaggtact
660 tctactttaa caattagtaa aaacagacaa aaaactaaac aacttgtatt
cacaaaagaa 720 gacacaataa cagtacaaaa ctacgactca gcaggcacca
atctagaagg caaagcagtc 780 gaaattacaa cacttaaaga acttaaaaac
gctttaaaat a 821 47 825 DNA Artificial Sequence Chimeric nucleic
acid 47 atg aaa aaa tat tta ttg gga ata ggt cta ata tta gcc tta ata
gca 48 Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile
Ala 1 5 10 15 tgt aag caa aat gtt agc agc ctt gat gaa aaa aat agc
gtt tca gta 96 Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser
Val Ser Val 20 25 30 gat tta cct ggt gga atg aca gtt ctt gta agt
aaa gaa aaa gac aaa 144 Asp Leu Pro Gly Gly Met Thr Val Leu Val Ser
Lys Glu Lys Asp Lys 35 40 45 gac ggt aaa tac agt cta gag gca aca
gta gac aag ctt gag ctt aaa 192 Asp Gly Lys Tyr Ser Leu Glu Ala Thr
Val Asp Lys Leu Glu Leu Lys 50 55 60 gga act tct gat aaa aac aac
ggt tct gga aca ctt gaa ggt gaa aaa 240 Gly Thr Ser Asp Lys Asn Asn
Gly Ser Gly Thr Leu Glu Gly Glu Lys 65 70 75 80 act gac aaa agt aaa
gta aaa tta aca att gct gat gac cta agt caa 288 Thr Asp Lys Ser Lys
Val Lys Leu Thr Ile Ala Asp Asp Leu Ser Gln 85 90 95 act aaa ttt
gaa att ttc aaa gaa gat gcc aaa aca tta gta tca aaa 336 Thr Lys Phe
Glu Ile Phe Lys Glu Asp Ala Lys Thr Leu Val Ser Lys 100 105 110 aaa
gta acc ctt aaa gac aag tca tca aca gaa gaa aaa ttc aac gaa 384 Lys
Val Thr Leu Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn Glu 115 120
125 aag ggt gaa aca tct gaa aaa aca ata gta aga gca aat gga acc aga
432 Lys Gly Glu Thr Ser Glu Lys Thr Ile Val Arg Ala Asn Gly Thr Arg
130 135 140 ctt gaa tac aca gac ata aaa agc gat gga tcc gga aaa gct
aaa gaa 480 Leu Glu Tyr Thr Asp Ile Lys Ser Asp Gly Ser Gly Lys Ala
Lys Glu 145 150 155 160 gtt tta aaa gac ttt act ctt gaa gga act cta
gct gct gac ggc aaa 528 Val Leu Lys Asp Phe Thr Leu Glu Gly Thr Leu
Ala Ala Asp Gly Lys 165 170 175 aca aca ttg aaa gtt aca gaa ggc act
gtt gtt tta agc aag aac att 576 Thr Thr Leu Lys Val Thr Glu Gly Thr
Val Val Leu Ser Lys Asn Ile 180 185 190 tta aaa tcc gga gaa ata aca
gtt gca ctt gat gac tct gac act act 624 Leu Lys Ser Gly Glu Ile Thr
Val Ala Leu Asp Asp Ser Asp Thr Thr 195 200 205 cag gct act aaa aaa
act gga aaa tgg gat tca aat act tcc act tta 672 Gln Ala Thr Lys Lys
Thr Gly Lys Trp Asp Ser Asn Thr Ser Thr Leu 210 215 220 aca att agt
gtg aat agc aaa aaa act aaa aac att gta ttt aca aaa 720 Thr Ile Ser
Val Asn Ser Lys Lys Thr Lys Asn Ile Val Phe Thr Lys 225 230 235 240
gaa gac aca ata aca gta caa aaa tac gac tca gca ggc acc aat cta 768
Glu Asp Thr Ile Thr Val Gln Lys Tyr Asp Ser Ala Gly Thr Asn Leu 245
250 255 gaa ggc aac gca gtc gaa att aaa aca ctt gat gaa ctt aaa aac
gct 816 Glu Gly Asn Ala Val Glu Ile Lys Thr Leu Asp Glu Leu Lys Asn
Ala 260 265 270 tta aaa tag 825 Leu Lys * 48 274 PRT Artificial
Sequence Chimeric protein 48 Met Lys Lys Tyr Leu Leu Gly Ile Gly
Leu Ile Leu Ala Leu Ile Ala 1 5 10 15 Cys Lys Gln Asn Val Ser Ser
Leu Asp Glu Lys Asn Ser Val Ser Val 20 25 30 Asp Leu Pro Gly Gly
Met Thr Val Leu Val Ser Lys Glu Lys Asp Lys 35 40 45 Asp Gly Lys
Tyr Ser Leu Glu Ala Thr Val Asp Lys Leu Glu Leu Lys 50 55 60 Gly
Thr Ser Asp Lys Asn Asn Gly Ser Gly Thr Leu Glu Gly Glu Lys 65 70
75 80 Thr Asp Lys Ser Lys Val Lys Leu Thr Ile Ala Asp Asp Leu Ser
Gln 85 90 95 Thr Lys Phe Glu Ile Phe Lys Glu Asp Ala Lys Thr Leu
Val Ser Lys 100 105 110 Lys Val Thr Leu Lys Asp Lys Ser Ser Thr Glu
Glu Lys Phe Asn Glu 115 120 125 Lys Gly Glu Thr Ser Glu Lys Thr Ile
Val Arg Ala Asn Gly Thr Arg 130 135 140 Leu Glu Tyr Thr Asp Ile Lys
Ser Asp Gly Ser Gly Lys Ala Lys Glu 145 150 155 160 Val Leu Lys Asp
Phe Thr Leu Glu Gly Thr Leu Ala Ala Asp Gly Lys 165 170 175 Thr Thr
Leu Lys Val Thr Glu Gly Thr Val Val Leu Ser Lys Asn Ile 180 185 190
Leu Lys Ser Gly Glu Ile Thr Val Ala Leu Asp Asp Ser Asp Thr Thr 195
200 205 Gln Ala Thr Lys Lys Thr Gly Lys Trp Asp Ser Asn Thr Ser Thr
Leu 210 215 220 Thr Ile Ser Val Asn Ser Lys Lys Thr Lys Asn Ile Val
Phe Thr Lys 225 230 235 240 Glu Asp Thr Ile Thr Val Gln Lys Tyr Asp
Ser Ala Gly Thr Asn Leu 245 250 255 Glu Gly Asn Ala Val Glu Ile Lys
Thr Leu Asp Glu Leu Lys Asn Ala 260 265 270 Leu Lys 49 822 DNA
Artificial Sequence Chimeric nucleic acid 49 atg aaa aaa tat tta
ttg gga ata ggt cta ata tta gcc tta ata gca 48 Met Lys Lys Tyr Leu
Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile Ala 1 5 10 15 tgc aag caa
aat gtt agc agc ctt gat gaa aaa aac agc gct tca gta 96 Cys Lys Gln
Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Ala Ser Val 20 25 30 gat
ttg cct ggt gag atg aaa gtt ctt gta agt aaa gaa aaa gac aaa 144 Asp
Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys Asp Lys 35 40
45 gac ggt aag tac agt cta aag gca aca gta gac aag att gag cta aaa
192 Asp Gly Lys Tyr Ser Leu Lys Ala Thr Val Asp Lys Ile Glu Leu Lys
50 55 60 gga act tct gat aaa gac aat ggt tct gga gtg ctt gaa ggt
aca aaa 240 Gly Thr Ser Asp Lys Asp Asn Gly Ser Gly Val Leu Glu Gly
Thr Lys 65 70 75 80 gat gac aaa agt aaa gca aaa tta aca att gct gac
gat cta agt aaa 288 Asp Asp Lys Ser Lys Ala Lys Leu Thr Ile Ala Asp
Asp Leu Ser Lys 85 90 95 acc aca ttc gaa ctt tta aaa gaa gat ggc
aaa aca tta gtg tca aga 336 Thr Thr Phe Glu Leu Leu Lys Glu Asp Gly
Lys Thr Leu Val Ser Arg 100 105 110 aaa gta agt tct aga gac aaa aca
tca aca gat gaa atg ttc aat gaa 384 Lys Val Ser Ser Arg Asp Lys Thr
Ser Thr Asp Glu Met Phe Asn Glu 115 120 125 aaa ggt gaa ttg tct gca
aaa acc atg aca aga gaa aat gga acc aaa 432 Lys Gly Glu Leu Ser Ala
Lys Thr Met Thr Arg Glu Asn Gly Thr Lys 130 135 140 ctt gaa tat aca
gaa atg aaa agc gat gga acc gga aaa gct aaa gaa 480 Leu Glu Tyr Thr
Glu Met Lys Ser Asp Gly Thr Gly Lys Ala Lys Glu 145 150 155 160 gtt
tta aaa aag ttt act ctt gaa gga aaa gta gct aat gat aaa gta 528 Val
Leu Lys Lys Phe Thr Leu Glu Gly Lys Val Ala Asn Asp Lys Val 165 170
175 aca ttg gaa gta aaa gaa gga acc gtt act tta agt aag gaa att gca
576 Thr Leu Glu Val Lys Glu Gly Thr Val Thr Leu Ser Lys Glu Ile Ala
180 185 190 aaa tct gga gaa gta aca gtt gct ctt aat gac act aac act
act cag 624 Lys Ser Gly Glu Val Thr Val Ala Leu Asn Asp Thr Asn Thr
Thr Gln 195 200 205 gct act aaa aaa act ggc gca tgg gat tca aaa act
tct act tta aca 672 Ala Thr Lys Lys Thr Gly Ala Trp Asp Ser Lys Thr
Ser Thr Leu Thr 210 215 220 att agt gtt aac agc aaa aaa act aca caa
ctt gtg ttt act aaa caa 720 Ile Ser Val Asn Ser Lys Lys Thr Thr Gln
Leu Val Phe Thr Lys Gln 225 230 235 240 gac aca ata act gta caa aaa
tac gac tcc gca ggt acc aat tta gaa 768 Asp Thr Ile Thr Val Gln Lys
Tyr Asp Ser Ala Gly Thr Asn Leu Glu 245 250 255 ggt aca gca gtc gaa
att aaa aca ctt gat gaa ctt aaa aac gct tta 816 Gly Thr Ala Val Glu
Ile Lys Thr Leu Asp Glu Leu Lys Asn Ala Leu 260 265 270 aaa tag 822
Lys * 50 273 PRT Artificial Sequence Chimeric protein 50 Met Lys
Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile Ala 1 5 10 15
Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Ala Ser Val 20
25 30 Asp Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys Asp
Lys 35 40 45 Asp Gly Lys Tyr Ser Leu Lys Ala Thr Val Asp Lys Ile
Glu Leu Lys 50 55 60 Gly Thr Ser Asp Lys Asp Asn Gly Ser Gly Val
Leu Glu Gly Thr Lys 65 70 75 80 Asp Asp Lys Ser Lys Ala Lys Leu Thr
Ile Ala Asp Asp Leu Ser Lys 85 90 95 Thr Thr Phe Glu Leu Leu Lys
Glu Asp Gly Lys Thr Leu Val Ser Arg 100 105 110 Lys Val Ser Ser Arg
Asp Lys Thr Ser Thr Asp Glu Met Phe Asn Glu 115 120 125 Lys Gly Glu
Leu Ser Ala Lys Thr Met Thr Arg Glu Asn Gly Thr Lys 130 135 140 Leu
Glu Tyr Thr Glu Met Lys Ser Asp Gly Thr Gly Lys Ala Lys Glu 145 150
155 160 Val Leu Lys Lys Phe Thr Leu Glu Gly Lys Val Ala Asn Asp Lys
Val 165 170 175 Thr Leu Glu Val Lys Glu Gly Thr Val Thr Leu Ser Lys
Glu Ile Ala 180 185 190 Lys Ser Gly Glu Val Thr Val Ala Leu Asn Asp
Thr Asn Thr Thr Gln 195 200 205 Ala Thr Lys Lys Thr Gly Ala Trp Asp
Ser Lys Thr Ser Thr Leu Thr 210 215 220 Ile Ser Val Asn Ser Lys Lys
Thr Thr Gln Leu Val Phe Thr Lys Gln 225 230 235 240 Asp Thr Ile Thr
Val Gln Lys Tyr Asp Ser Ala Gly Thr Asn Leu Glu 245 250 255 Gly Thr
Ala Val Glu Ile Lys Thr Leu Asp Glu Leu Lys Asn Ala Leu 260 265 270
Lys 51 822 DNA Artificial Sequence Chimeric nucleic acid 51 atg aaa
aaa tat tta ttg gga ata ggt cta ata tta gcc tta ata gca 48 Met Lys
Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile Ala 1 5 10 15
tgc aag caa aat gtt agc agc ctt gat gaa aaa aac agc gct tca gta 96
Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Ala Ser Val 20
25 30 gat ttg cct ggt gag atg aaa gtt ctt gta agt aaa gaa aaa gac
aaa 144 Asp Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys Asp
Lys 35 40 45 gac ggt aag tac agt cta aag gca aca gta gac aag att
gag cta aaa 192 Asp Gly Lys Tyr Ser Leu Lys Ala Thr Val Asp Lys Ile
Glu Leu Lys 50 55 60 gga act tct gat aaa gac aat ggt tct gga gtg
ctt gaa ggt aca aaa 240 Gly Thr Ser Asp Lys Asp Asn Gly Ser Gly Val
Leu Glu Gly Thr Lys 65 70 75 80 gat gac aaa agt aaa gca aaa tta aca
att gct gac gat cta agt aaa 288 Asp Asp Lys Ser Lys Ala Lys Leu Thr
Ile Ala Asp Asp Leu Ser Lys 85 90 95 acc aca ttc gaa ctt tta aaa
gaa gat ggc aaa aca tta gtg tca aga 336 Thr Thr Phe Glu Leu Leu Lys
Glu Asp Gly Lys Thr Leu Val Ser Arg 100 105 110 aaa gta agt tct aga
gac aaa aca tca aca gat gaa atg ttc aat gaa 384 Lys Val Ser Ser Arg
Asp Lys Thr Ser Thr Asp Glu Met Phe Asn Glu 115 120 125 aaa ggt gaa
ttg tct gca aaa acc atg aca aga gaa aat gga acc aaa 432 Lys Gly Glu
Leu Ser Ala Lys Thr Met Thr Arg Glu Asn Gly Thr Lys 130 135 140 ctt
gaa tat aca gaa atg aaa agc gat gga acc gga aaa gct aaa gaa 480 Leu
Glu Tyr Thr Glu Met Lys Ser Asp Gly Thr Gly Lys Ala Lys Glu 145 150
155 160 gtt tta aaa aag ttt act ctt gaa gga aaa gta gct aat gat aaa
gta 528 Val Leu Lys Lys Phe Thr Leu Glu Gly Lys Val Ala Asn Asp Lys
Val 165 170 175 aca ttg gaa gta aaa gaa gga acc gtt act tta agt aag
gaa att tca 576 Thr Leu Glu Val Lys Glu Gly Thr Val Thr Leu Ser Lys
Glu Ile Ser 180 185 190 aaa tct ggg gaa gtt tca gtt gaa ctt aat gac
act gac agt agt gct 624 Lys Ser Gly Glu Val Ser Val Glu Leu Asn Asp
Thr Asp Ser Ser Ala 195 200 205 gct act aaa aaa act gca gct tgg aat
tca aaa act tcc act tta aca 672 Ala Thr Lys Lys Thr Ala Ala Trp Asn
Ser Lys Thr Ser Thr Leu Thr 210 215 220 att agt gtg aat agc caa aaa
acc aaa aac ctt gta ttc aca aaa gaa 720 Ile Ser Val Asn Ser Gln Lys
Thr Lys Asn Leu Val Phe Thr Lys Glu 225 230 235 240 gac aca ata aca
gta caa aaa tac gac tca gca ggc acc aat cta gaa 768 Asp Thr Ile Thr
Val Gln Lys Tyr Asp Ser Ala Gly Thr Asn Leu Glu 245 250 255 ggc aaa
gca gtc gaa att aca aca ctt aaa gaa ctt aaa aac gct tta 816 Gly Lys
Ala Val Glu Ile Thr Thr Leu Lys Glu Leu Lys Asn Ala Leu 260 265 270
aaa taa 822 Lys * 52 273 PRT Artificial Sequence Chimeric protein
52 Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile Ala
1 5 10 15 Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Ala
Ser Val 20 25 30 Asp Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys
Glu Lys Asp Lys 35 40 45 Asp Gly Lys Tyr Ser Leu Lys Ala Thr Val
Asp Lys Ile Glu Leu Lys 50 55 60 Gly Thr Ser Asp Lys Asp Asn Gly
Ser Gly Val Leu Glu Gly Thr Lys 65 70 75 80 Asp Asp Lys Ser Lys Ala
Lys Leu Thr Ile Ala Asp Asp Leu Ser Lys 85 90 95 Thr Thr Phe Glu
Leu Leu Lys Glu Asp Gly Lys Thr Leu Val Ser Arg 100 105 110 Lys Val
Ser Ser Arg Asp Lys Thr Ser Thr Asp Glu Met Phe Asn Glu 115 120 125
Lys Gly Glu Leu Ser Ala Lys Thr Met Thr Arg Glu Asn Gly Thr Lys 130
135 140 Leu Glu Tyr Thr Glu Met Lys Ser Asp Gly Thr Gly Lys Ala Lys
Glu 145 150 155 160 Val Leu Lys Lys Phe Thr Leu Glu Gly Lys Val Ala
Asn Asp Lys Val 165 170 175 Thr Leu Glu Val Lys Glu Gly Thr Val Thr
Leu Ser Lys Glu Ile Ser 180 185 190 Lys Ser Gly Glu Val Ser Val Glu
Leu Asn Asp Thr Asp Ser Ser Ala 195 200 205 Ala Thr Lys Lys Thr Ala
Ala Trp Asn Ser Lys Thr Ser Thr Leu Thr 210 215 220 Ile Ser Val Asn
Ser Gln Lys Thr Lys Asn Leu Val Phe Thr Lys Glu 225 230 235 240 Asp
Thr Ile Thr Val Gln Lys Tyr Asp Ser Ala Gly Thr Asn Leu Glu 245 250
255 Gly Lys Ala Val Glu Ile Thr Thr Leu Lys Glu Leu Lys Asn Ala Leu
260 265 270 Lys 53 822 DNA Artificial Sequence Chimeric nucleic
acid 53 atg aaa aaa tat tta ttg gga ata ggt cta ata tta gcc tta ata
gca 48 Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile
Ala 1 5 10 15 tgt aag caa aat gtt agc agc ctt gac gag aaa aac agc
gtt tca gta 96 Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser
Val Ser Val 20 25 30 gat ttg cct ggt gaa atg aaa gtt ctt gta agc
aaa gaa aaa aac aaa 144 Asp Leu Pro Gly Glu Met Lys Val Leu Val Ser
Lys Glu Lys Asn Lys 35 40 45 gac ggc aag tac gat cta att gca aca
gta gac aag ctt gag ctt aaa 192 Asp Gly Lys Tyr Asp Leu Ile Ala Thr
Val Asp Lys Leu Glu Leu Lys 50 55 60 gga act tct gat aaa aac aat
gga tct gga gta ctt gaa ggc gta aaa 240 Gly Thr Ser Asp Lys Asn Asn
Gly Ser Gly Val Leu Glu Gly Val Lys 65 70 75 80 gct gac aaa agt aaa
gta aaa tta aca att tct gac gat cta ggt caa 288 Ala Asp Lys Ser Lys
Val Lys Leu Thr Ile Ser Asp
Asp Leu Gly Gln 85 90 95 acc aca ctt gaa gtt ttc aaa gaa gat ggc
aaa aca cta gta tca aaa 336 Thr Thr Leu Glu Val Phe Lys Glu Asp Gly
Lys Thr Leu Val Ser Lys 100 105 110 aaa gta act tcc aaa gac aag tca
tca aca gaa gaa aaa ttc aat gaa 384 Lys Val Thr Ser Lys Asp Lys Ser
Ser Thr Glu Glu Lys Phe Asn Glu 115 120 125 aaa ggt gaa gta tct gaa
aaa ata ata aca aga gca aat gga acc aaa 432 Lys Gly Glu Val Ser Glu
Lys Ile Ile Thr Arg Ala Asn Gly Thr Lys 130 135 140 ctt gaa tat aca
gaa atg aaa agc gat gga acc gga aaa gct aaa gaa 480 Leu Glu Tyr Thr
Glu Met Lys Ser Asp Gly Thr Gly Lys Ala Lys Glu 145 150 155 160 gtt
tta aaa aag ttt act ctt gaa gga aaa gta gct aat gat aaa gta 528 Val
Leu Lys Lys Phe Thr Leu Glu Gly Lys Val Ala Asn Asp Lys Val 165 170
175 aca ttg gaa gta aaa gaa gga acc gtt act tta agt aag gaa att tca
576 Thr Leu Glu Val Lys Glu Gly Thr Val Thr Leu Ser Lys Glu Ile Ser
180 185 190 aaa tct ggg gaa gtt tca gtt gaa ctt aat gac act gac agt
agt gct 624 Lys Ser Gly Glu Val Ser Val Glu Leu Asn Asp Thr Asp Ser
Ser Ala 195 200 205 gct act aaa aaa act gca gct tgg aat tca aaa act
tcc act tta aca 672 Ala Thr Lys Lys Thr Ala Ala Trp Asn Ser Lys Thr
Ser Thr Leu Thr 210 215 220 att agt gtg aat agc caa aaa acc aaa aac
ctt gta ttc aca aaa gaa 720 Ile Ser Val Asn Ser Gln Lys Thr Lys Asn
Leu Val Phe Thr Lys Glu 225 230 235 240 gac aca ata aca gta caa aaa
tac gac tca gca ggc acc aat cta gaa 768 Asp Thr Ile Thr Val Gln Lys
Tyr Asp Ser Ala Gly Thr Asn Leu Glu 245 250 255 ggc aaa gca gtc gaa
att aca aca ctt aaa gaa ctt aaa aac gct tta 816 Gly Lys Ala Val Glu
Ile Thr Thr Leu Lys Glu Leu Lys Asn Ala Leu 260 265 270 aaa taa 822
Lys * 54 273 PRT Artificial Sequence Chimeric protein 54 Met Lys
Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile Ala 1 5 10 15
Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val Ser Val 20
25 30 Asp Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys Asn
Lys 35 40 45 Asp Gly Lys Tyr Asp Leu Ile Ala Thr Val Asp Lys Leu
Glu Leu Lys 50 55 60 Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Val
Leu Glu Gly Val Lys 65 70 75 80 Ala Asp Lys Ser Lys Val Lys Leu Thr
Ile Ser Asp Asp Leu Gly Gln 85 90 95 Thr Thr Leu Glu Val Phe Lys
Glu Asp Gly Lys Thr Leu Val Ser Lys 100 105 110 Lys Val Thr Ser Lys
Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn Glu 115 120 125 Lys Gly Glu
Val Ser Glu Lys Ile Ile Thr Arg Ala Asn Gly Thr Lys 130 135 140 Leu
Glu Tyr Thr Glu Met Lys Ser Asp Gly Thr Gly Lys Ala Lys Glu 145 150
155 160 Val Leu Lys Lys Phe Thr Leu Glu Gly Lys Val Ala Asn Asp Lys
Val 165 170 175 Thr Leu Glu Val Lys Glu Gly Thr Val Thr Leu Ser Lys
Glu Ile Ser 180 185 190 Lys Ser Gly Glu Val Ser Val Glu Leu Asn Asp
Thr Asp Ser Ser Ala 195 200 205 Ala Thr Lys Lys Thr Ala Ala Trp Asn
Ser Lys Thr Ser Thr Leu Thr 210 215 220 Ile Ser Val Asn Ser Gln Lys
Thr Lys Asn Leu Val Phe Thr Lys Glu 225 230 235 240 Asp Thr Ile Thr
Val Gln Lys Tyr Asp Ser Ala Gly Thr Asn Leu Glu 245 250 255 Gly Lys
Ala Val Glu Ile Thr Thr Leu Lys Glu Leu Lys Asn Ala Leu 260 265 270
Lys 55 1362 DNA Artificial Sequence Chimeric nucleic acid 55 atg
gct tgt aat aat tca ggg aaa gat ggg aat aca tct gca aat tct 48 Met
Ala Cys Asn Asn Ser Gly Lys Asp Gly Asn Thr Ser Ala Asn Ser 1 5 10
15 gct gat gag tct gtt aaa ggg cct aat ctt aca gaa ata aat aaa aaa
96 Ala Asp Glu Ser Val Lys Gly Pro Asn Leu Thr Glu Ile Asn Lys Lys
20 25 30 att acg gat tct aat gcg gtt tta ctt gct gtg aaa gag gtt
gaa gcg 144 Ile Thr Asp Ser Asn Ala Val Leu Leu Ala Val Lys Glu Val
Glu Ala 35 40 45 ttg ctg tca tct ata gat gaa att gct gct aaa gct
att ggt aaa aaa 192 Leu Leu Ser Ser Ile Asp Glu Ile Ala Ala Lys Ala
Ile Gly Lys Lys 50 55 60 ata cac caa aat aat ggt ttg gat acc gaa
aat aat cac aat gga tca 240 Ile His Gln Asn Asn Gly Leu Asp Thr Glu
Asn Asn His Asn Gly Ser 65 70 75 80 ttg tta gcg gga gct tat gca ata
tca acc cta ata aaa caa aaa tta 288 Leu Leu Ala Gly Ala Tyr Ala Ile
Ser Thr Leu Ile Lys Gln Lys Leu 85 90 95 gat gga ttg aaa aat gaa
gga tta aag gaa aaa att gat gcg gct aag 336 Asp Gly Leu Lys Asn Glu
Gly Leu Lys Glu Lys Ile Asp Ala Ala Lys 100 105 110 aaa tgt tct gaa
aca ttt act aat aaa tta aaa gaa aaa cac aca gat 384 Lys Cys Ser Glu
Thr Phe Thr Asn Lys Leu Lys Glu Lys His Thr Asp 115 120 125 ctt ggt
aaa gaa ggt gtt act gat gct gat gca aaa gaa gcc att tta 432 Leu Gly
Lys Glu Gly Val Thr Asp Ala Asp Ala Lys Glu Ala Ile Leu 130 135 140
aaa gca aat ggt act aaa act aaa ggt gct gaa gaa ctt gga aaa tta 480
Lys Ala Asn Gly Thr Lys Thr Lys Gly Ala Glu Glu Leu Gly Lys Leu 145
150 155 160 ttt gaa tca gta gag gtc ttg tca aaa gca gct aaa gag atg
ctt gct 528 Phe Glu Ser Val Glu Val Leu Ser Lys Ala Ala Lys Glu Met
Leu Ala 165 170 175 aat tca gtt aaa gag ctt aca agc cct gtt gtg gca
gaa agt cca aaa 576 Asn Ser Val Lys Glu Leu Thr Ser Pro Val Val Ala
Glu Ser Pro Lys 180 185 190 aaa cct tcc atg gcc aag caa aat gtt agc
agc ctt gac gag aaa aac 624 Lys Pro Ser Met Ala Lys Gln Asn Val Ser
Ser Leu Asp Glu Lys Asn 195 200 205 agc gtt tca gta gat ttg cct ggt
gaa atg aaa gtt ctt gta agc aaa 672 Ser Val Ser Val Asp Leu Pro Gly
Glu Met Lys Val Leu Val Ser Lys 210 215 220 gaa aaa aac aaa gac ggc
aag tac gat cta att gca aca gta gac aag 720 Glu Lys Asn Lys Asp Gly
Lys Tyr Asp Leu Ile Ala Thr Val Asp Lys 225 230 235 240 ctt gag ctt
aaa gga act tct gat aaa aac aat gga tct gga gta ctt 768 Leu Glu Leu
Lys Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Val Leu 245 250 255 gaa
ggc gta aaa gct gac aaa agt aaa gta aaa tta aca att tct gac 816 Glu
Gly Val Lys Ala Asp Lys Ser Lys Val Lys Leu Thr Ile Ser Asp 260 265
270 gat cta ggt caa acc aca ctt gaa gtt ttc aaa gaa gat ggc aaa aca
864 Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys Glu Asp Gly Lys Thr
275 280 285 cta gta tca aaa aaa gta act tcc aaa gac aag tca tca aca
gaa gaa 912 Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys Ser Ser Thr
Glu Glu 290 295 300 aaa ttc aat gaa aaa ggt gaa gta tct gaa aaa ata
ata aca aga gca 960 Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys Ile
Ile Thr Arg Ala 305 310 315 320 gac gga acc aga ctt gaa tac aca gga
att aaa agc gat gga tct gga 1008 Asp Gly Thr Arg Leu Glu Tyr Thr
Gly Ile Lys Ser Asp Gly Ser Gly 325 330 335 aaa gct aaa gag gtt tta
aaa ggc tat gtt ctt gaa gga act cta act 1056 Lys Ala Lys Glu Val
Leu Lys Gly Tyr Val Leu Glu Gly Thr Leu Thr 340 345 350 gct gaa aaa
aca aca ttg gtg gtt aaa gaa gga act gtt act tta agc 1104 Ala Glu
Lys Thr Thr Leu Val Val Lys Glu Gly Thr Val Thr Leu Ser 355 360 365
aaa aat att tca aaa tct ggg gaa gtt tca gtt gaa ctt aat gac act
1152 Lys Asn Ile Ser Lys Ser Gly Glu Val Ser Val Glu Leu Asn Asp
Thr 370 375 380 gac agt agt gct gct act aaa aaa act gca gct tgg aat
tca ggc act 1200 Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala Trp
Asn Ser Gly Thr 385 390 395 400 tca act tta aca att act gta aac agt
aaa aaa act aaa gac ctt gtg 1248 Ser Thr Leu Thr Ile Thr Val Asn
Ser Lys Lys Thr Lys Asp Leu Val 405 410 415 ttt aca aaa gaa aac aca
att aca gta caa caa tac gac tca aat ggc 1296 Phe Thr Lys Glu Asn
Thr Ile Thr Val Gln Gln Tyr Asp Ser Asn Gly 420 425 430 acc aaa tta
gag ggg tca gca gtt gaa att aca aaa ctt gat gaa att 1344 Thr Lys
Leu Glu Gly Ser Ala Val Glu Ile Thr Lys Leu Asp Glu Ile 435 440 445
aaa aac gct tta aaa taa 1362 Lys Asn Ala Leu Lys * 450 56 453 PRT
Artificial Sequence Chimeric protein 56 Met Ala Cys Asn Asn Ser Gly
Lys Asp Gly Asn Thr Ser Ala Asn Ser 1 5 10 15 Ala Asp Glu Ser Val
Lys Gly Pro Asn Leu Thr Glu Ile Asn Lys Lys 20 25 30 Ile Thr Asp
Ser Asn Ala Val Leu Leu Ala Val Lys Glu Val Glu Ala 35 40 45 Leu
Leu Ser Ser Ile Asp Glu Ile Ala Ala Lys Ala Ile Gly Lys Lys 50 55
60 Ile His Gln Asn Asn Gly Leu Asp Thr Glu Asn Asn His Asn Gly Ser
65 70 75 80 Leu Leu Ala Gly Ala Tyr Ala Ile Ser Thr Leu Ile Lys Gln
Lys Leu 85 90 95 Asp Gly Leu Lys Asn Glu Gly Leu Lys Glu Lys Ile
Asp Ala Ala Lys 100 105 110 Lys Cys Ser Glu Thr Phe Thr Asn Lys Leu
Lys Glu Lys His Thr Asp 115 120 125 Leu Gly Lys Glu Gly Val Thr Asp
Ala Asp Ala Lys Glu Ala Ile Leu 130 135 140 Lys Ala Asn Gly Thr Lys
Thr Lys Gly Ala Glu Glu Leu Gly Lys Leu 145 150 155 160 Phe Glu Ser
Val Glu Val Leu Ser Lys Ala Ala Lys Glu Met Leu Ala 165 170 175 Asn
Ser Val Lys Glu Leu Thr Ser Pro Val Val Ala Glu Ser Pro Lys 180 185
190 Lys Pro Ser Met Ala Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn
195 200 205 Ser Val Ser Val Asp Leu Pro Gly Glu Met Lys Val Leu Val
Ser Lys 210 215 220 Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile Ala
Thr Val Asp Lys 225 230 235 240 Leu Glu Leu Lys Gly Thr Ser Asp Lys
Asn Asn Gly Ser Gly Val Leu 245 250 255 Glu Gly Val Lys Ala Asp Lys
Ser Lys Val Lys Leu Thr Ile Ser Asp 260 265 270 Asp Leu Gly Gln Thr
Thr Leu Glu Val Phe Lys Glu Asp Gly Lys Thr 275 280 285 Leu Val Ser
Lys Lys Val Thr Ser Lys Asp Lys Ser Ser Thr Glu Glu 290 295 300 Lys
Phe Asn Glu Lys Gly Glu Val Ser Glu Lys Ile Ile Thr Arg Ala 305 310
315 320 Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys Ser Asp Gly Ser
Gly 325 330 335 Lys Ala Lys Glu Val Leu Lys Gly Tyr Val Leu Glu Gly
Thr Leu Thr 340 345 350 Ala Glu Lys Thr Thr Leu Val Val Lys Glu Gly
Thr Val Thr Leu Ser 355 360 365 Lys Asn Ile Ser Lys Ser Gly Glu Val
Ser Val Glu Leu Asn Asp Thr 370 375 380 Asp Ser Ser Ala Ala Thr Lys
Lys Thr Ala Ala Trp Asn Ser Gly Thr 385 390 395 400 Ser Thr Leu Thr
Ile Thr Val Asn Ser Lys Lys Thr Lys Asp Leu Val 405 410 415 Phe Thr
Lys Glu Asn Thr Ile Thr Val Gln Gln Tyr Asp Ser Asn Gly 420 425 430
Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr Lys Leu Asp Glu Ile 435
440 445 Lys Asn Ala Leu Lys 450 57 1353 DNA Artificial Sequence
Chimeric nucleic acid 57 atg gct tgt aat aat tca ggg aaa gat ggg
aat aca tct gca aat tct 48 Met Ala Cys Asn Asn Ser Gly Lys Asp Gly
Asn Thr Ser Ala Asn Ser 1 5 10 15 gct gat gag tct gtt aaa ggg cct
aat ctt aca gaa ata aat aaa aaa 96 Ala Asp Glu Ser Val Lys Gly Pro
Asn Leu Thr Glu Ile Asn Lys Lys 20 25 30 att acg gat tct aat gcg
gtt tta ctt gct gtg aaa gag gtt gaa gcg 144 Ile Thr Asp Ser Asn Ala
Val Leu Leu Ala Val Lys Glu Val Glu Ala 35 40 45 ttg ctg tca tct
ata gat gaa att gct gct aaa gct att ggt aaa aaa 192 Leu Leu Ser Ser
Ile Asp Glu Ile Ala Ala Lys Ala Ile Gly Lys Lys 50 55 60 ata cac
caa aat aat ggt ttg gat acc gaa aat aat cac aat gga tca 240 Ile His
Gln Asn Asn Gly Leu Asp Thr Glu Asn Asn His Asn Gly Ser 65 70 75 80
ttg tta gcg gga gct tat gca ata tca acc cta ata aaa caa aaa tta 288
Leu Leu Ala Gly Ala Tyr Ala Ile Ser Thr Leu Ile Lys Gln Lys Leu 85
90 95 gat gga ttg aaa aat gaa gga tta aag gaa aaa att gat gcg gct
aag 336 Asp Gly Leu Lys Asn Glu Gly Leu Lys Glu Lys Ile Asp Ala Ala
Lys 100 105 110 aaa tgt tct gaa aca ttt act aat aaa tta aaa gaa aaa
cac aca gat 384 Lys Cys Ser Glu Thr Phe Thr Asn Lys Leu Lys Glu Lys
His Thr Asp 115 120 125 ctt ggt aaa gaa ggt gtt act gat gct gat gca
aaa gaa gcc att tta 432 Leu Gly Lys Glu Gly Val Thr Asp Ala Asp Ala
Lys Glu Ala Ile Leu 130 135 140 aaa gca aat ggt act aaa act aaa ggt
gct gaa gaa ctt gga aaa tta 480 Lys Ala Asn Gly Thr Lys Thr Lys Gly
Ala Glu Glu Leu Gly Lys Leu 145 150 155 160 ttt gaa tca gta gag gtc
ttg tca aaa gca gct aaa gag atg ctt gct 528 Phe Glu Ser Val Glu Val
Leu Ser Lys Ala Ala Lys Glu Met Leu Ala 165 170 175 aat tca gtt aaa
gag ctt aca agc cct gtt gtg gca gaa agt cca gcc 576 Asn Ser Val Lys
Glu Leu Thr Ser Pro Val Val Ala Glu Ser Pro Ala 180 185 190 atg gcc
aag caa aat gtt agc agc ctt gac gag aaa aac agc gtt tca 624 Met Ala
Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val Ser 195 200 205
gta gat ttg cct ggt gaa atg aaa gtt ctt gta agc aaa gaa aaa aac 672
Val Asp Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys Asn 210
215 220 aaa gac ggc aag tac gat cta att gca aca gta gac aag ctt gag
ctt 720 Lys Asp Gly Lys Tyr Asp Leu Ile Ala Thr Val Asp Lys Leu Glu
Leu 225 230 235 240 aaa gga act tct gat aaa aac aat gga tct gga gta
ctt gaa ggc gta 768 Lys Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Val
Leu Glu Gly Val 245 250 255 aaa gct gac aaa agt aaa gta aaa tta aca
att tct gac gat cta ggt 816 Lys Ala Asp Lys Ser Lys Val Lys Leu Thr
Ile Ser Asp Asp Leu Gly 260 265 270 caa acc aca ctt gaa gtt ttc aaa
gaa gat ggc aaa aca cta gta tca 864 Gln Thr Thr Leu Glu Val Phe Lys
Glu Asp Gly Lys Thr Leu Val Ser 275 280 285 aaa aaa gta act tcc aaa
gac aag tca tca aca gaa gaa aaa ttc aat 912 Lys Lys Val Thr Ser Lys
Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn 290 295 300 gaa aaa ggt gaa
gta tct gaa aaa ata ata aca aga gca gac gga acc 960 Glu Lys Gly Glu
Val Ser Glu Lys Ile Ile Thr Arg Ala Asp Gly Thr 305 310 315 320 aga
ctt gaa tac aca gga att aaa agc gat gga tct gga aaa gct aaa 1008
Arg Leu Glu Tyr Thr Gly Ile Lys Ser Asp Gly Ser Gly Lys Ala Lys 325
330 335 gag gtt tta aaa ggc tat gtt ctt gaa gga act cta act gct gaa
aaa 1056 Glu Val Leu Lys Gly Tyr Val Leu Glu Gly Thr Leu Thr Ala
Glu Lys 340 345 350 aca aca ttg gtg gtt aaa gaa gga act gtt act tta
agc aaa aat att 1104 Thr Thr Leu Val Val Lys Glu Gly Thr Val Thr
Leu Ser Lys Asn Ile 355 360 365 tca aaa tct ggg gaa gtt tca gtt gaa
ctt aat gac act gac agt agt 1152 Ser Lys Ser Gly Glu Val Ser Val
Glu Leu Asn Asp Thr Asp Ser Ser 370 375 380 gct gct act aaa aaa act
gca gct tgg aat tca ggc act tca act tta 1200 Ala Ala Thr Lys Lys
Thr Ala Ala Trp Asn Ser Gly Thr Ser Thr Leu 385 390 395 400 aca att
act gta aac agt aaa aaa act aaa gac ctt gtg ttt aca aaa 1248 Thr
Ile Thr Val Asn Ser Lys
Lys Thr Lys Asp Leu Val Phe Thr Lys 405 410 415 gaa aac aca att aca
gta caa caa tac gac tca aat ggc acc aaa tta 1296 Glu Asn Thr Ile
Thr Val Gln Gln Tyr Asp Ser Asn Gly Thr Lys Leu 420 425 430 gag ggg
tca gca gtt gaa att aca aaa ctt gat gaa att aaa aac gct 1344 Glu
Gly Ser Ala Val Glu Ile Thr Lys Leu Asp Glu Ile Lys Asn Ala 435 440
445 tta aaa taa 1353 Leu Lys * 450 58 450 PRT Artificial Sequence
Chimeric protein 58 Met Ala Cys Asn Asn Ser Gly Lys Asp Gly Asn Thr
Ser Ala Asn Ser 1 5 10 15 Ala Asp Glu Ser Val Lys Gly Pro Asn Leu
Thr Glu Ile Asn Lys Lys 20 25 30 Ile Thr Asp Ser Asn Ala Val Leu
Leu Ala Val Lys Glu Val Glu Ala 35 40 45 Leu Leu Ser Ser Ile Asp
Glu Ile Ala Ala Lys Ala Ile Gly Lys Lys 50 55 60 Ile His Gln Asn
Asn Gly Leu Asp Thr Glu Asn Asn His Asn Gly Ser 65 70 75 80 Leu Leu
Ala Gly Ala Tyr Ala Ile Ser Thr Leu Ile Lys Gln Lys Leu 85 90 95
Asp Gly Leu Lys Asn Glu Gly Leu Lys Glu Lys Ile Asp Ala Ala Lys 100
105 110 Lys Cys Ser Glu Thr Phe Thr Asn Lys Leu Lys Glu Lys His Thr
Asp 115 120 125 Leu Gly Lys Glu Gly Val Thr Asp Ala Asp Ala Lys Glu
Ala Ile Leu 130 135 140 Lys Ala Asn Gly Thr Lys Thr Lys Gly Ala Glu
Glu Leu Gly Lys Leu 145 150 155 160 Phe Glu Ser Val Glu Val Leu Ser
Lys Ala Ala Lys Glu Met Leu Ala 165 170 175 Asn Ser Val Lys Glu Leu
Thr Ser Pro Val Val Ala Glu Ser Pro Ala 180 185 190 Met Ala Lys Gln
Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val Ser 195 200 205 Val Asp
Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys Asn 210 215 220
Lys Asp Gly Lys Tyr Asp Leu Ile Ala Thr Val Asp Lys Leu Glu Leu 225
230 235 240 Lys Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Val Leu Glu
Gly Val 245 250 255 Lys Ala Asp Lys Ser Lys Val Lys Leu Thr Ile Ser
Asp Asp Leu Gly 260 265 270 Gln Thr Thr Leu Glu Val Phe Lys Glu Asp
Gly Lys Thr Leu Val Ser 275 280 285 Lys Lys Val Thr Ser Lys Asp Lys
Ser Ser Thr Glu Glu Lys Phe Asn 290 295 300 Glu Lys Gly Glu Val Ser
Glu Lys Ile Ile Thr Arg Ala Asp Gly Thr 305 310 315 320 Arg Leu Glu
Tyr Thr Gly Ile Lys Ser Asp Gly Ser Gly Lys Ala Lys 325 330 335 Glu
Val Leu Lys Gly Tyr Val Leu Glu Gly Thr Leu Thr Ala Glu Lys 340 345
350 Thr Thr Leu Val Val Lys Glu Gly Thr Val Thr Leu Ser Lys Asn Ile
355 360 365 Ser Lys Ser Gly Glu Val Ser Val Glu Leu Asn Asp Thr Asp
Ser Ser 370 375 380 Ala Ala Thr Lys Lys Thr Ala Ala Trp Asn Ser Gly
Thr Ser Thr Leu 385 390 395 400 Thr Ile Thr Val Asn Ser Lys Lys Thr
Lys Asp Leu Val Phe Thr Lys 405 410 415 Glu Asn Thr Ile Thr Val Gln
Gln Tyr Asp Ser Asn Gly Thr Lys Leu 420 425 430 Glu Gly Ser Ala Val
Glu Ile Thr Lys Leu Asp Glu Ile Lys Asn Ala 435 440 445 Leu Lys 450
59 1341 DNA Artificial Sequence Chimeric nucleic acid 59 atg gct
tgt aat aat tca ggg aaa gat ggg aat aca tct gca aat tct 48 Met Ala
Cys Asn Asn Ser Gly Lys Asp Gly Asn Thr Ser Ala Asn Ser 1 5 10 15
gct gat gag tct gtt aaa ggg cct aat ctt aca gaa ata agt aaa aaa 96
Ala Asp Glu Ser Val Lys Gly Pro Asn Leu Thr Glu Ile Ser Lys Lys 20
25 30 att acg gat tct aat gcg gtt tta ctt gct gtg aaa gag gtt gaa
gcg 144 Ile Thr Asp Ser Asn Ala Val Leu Leu Ala Val Lys Glu Val Glu
Ala 35 40 45 ttg ctg tca tct ata gat gag ctt gct aaa gct att ggt
aaa aaa ata 192 Leu Leu Ser Ser Ile Asp Glu Leu Ala Lys Ala Ile Gly
Lys Lys Ile 50 55 60 aaa aac gat ggt agt tta gat aat gaa gca aat
cgc aac gag tca ttg 240 Lys Asn Asp Gly Ser Leu Asp Asn Glu Ala Asn
Arg Asn Glu Ser Leu 65 70 75 80 tta gca gga gct tat aca ata tca acc
tta ata aca caa aaa tta agt 288 Leu Ala Gly Ala Tyr Thr Ile Ser Thr
Leu Ile Thr Gln Lys Leu Ser 85 90 95 aaa tta aac gga tca gaa ggt
tta aag gaa aag att gcc gca gct aag 336 Lys Leu Asn Gly Ser Glu Gly
Leu Lys Glu Lys Ile Ala Ala Ala Lys 100 105 110 aaa tgc tct gaa gag
ttt agt act aaa cta aaa gat aat cat gca cag 384 Lys Cys Ser Glu Glu
Phe Ser Thr Lys Leu Lys Asp Asn His Ala Gln 115 120 125 ctt ggt ata
cag ggc gtt act gat gaa aat gca aaa aaa gct att tta 432 Leu Gly Ile
Gln Gly Val Thr Asp Glu Asn Ala Lys Lys Ala Ile Leu 130 135 140 aaa
gca aat gca gcg ggt aaa gat aag ggc gtt gaa gaa ctt gaa aag 480 Lys
Ala Asn Ala Ala Gly Lys Asp Lys Gly Val Glu Glu Leu Glu Lys 145 150
155 160 ttg tcc gga tca tta gaa agc tta tca aaa gca gct aaa gag atg
ctt 528 Leu Ser Gly Ser Leu Glu Ser Leu Ser Lys Ala Ala Lys Glu Met
Leu 165 170 175 gct aat tca gtt aaa gag ctt aca agc cct gtt gtc cat
ggc aag caa 576 Ala Asn Ser Val Lys Glu Leu Thr Ser Pro Val Val His
Gly Lys Gln 180 185 190 aat gtt agc agc ctt gac gag aaa aac agc gtt
tca gta gat ttg cct 624 Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val
Ser Val Asp Leu Pro 195 200 205 ggt gaa atg aaa gtt ctt gta agc aaa
gaa aaa aac aaa gac ggc aag 672 Gly Glu Met Lys Val Leu Val Ser Lys
Glu Lys Asn Lys Asp Gly Lys 210 215 220 tac gat cta att gca aca gta
gac aag ctt gag ctt aaa gga act tct 720 Tyr Asp Leu Ile Ala Thr Val
Asp Lys Leu Glu Leu Lys Gly Thr Ser 225 230 235 240 gat aaa aac aat
gga tct gga gta ctt gaa ggc gta aaa gct gac aaa 768 Asp Lys Asn Asn
Gly Ser Gly Val Leu Glu Gly Val Lys Ala Asp Lys 245 250 255 agt aaa
gta aaa tta aca att tct gac gat cta ggt caa acc aca ctt 816 Ser Lys
Val Lys Leu Thr Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu 260 265 270
gaa gtt ttc aaa gaa gat ggc aaa aca cta gta tca aaa aaa gta act 864
Glu Val Phe Lys Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr 275
280 285 tcc aaa gac aag tca tca aca gaa gaa aaa ttc aat gaa aaa ggt
gaa 912 Ser Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly
Glu 290 295 300 gta tct gaa aaa ata ata aca aga gca gac gga acc aga
ctt gaa tac 960 Val Ser Glu Lys Ile Ile Thr Arg Ala Asp Gly Thr Arg
Leu Glu Tyr 305 310 315 320 aca gga att aaa agc gat gga tct gga aaa
gct aaa gag gtt tta aaa 1008 Thr Gly Ile Lys Ser Asp Gly Ser Gly
Lys Ala Lys Glu Val Leu Lys 325 330 335 ggc tat gtt ctt gaa gga act
cta act gct gaa aaa aca aca ttg gtg 1056 Gly Tyr Val Leu Glu Gly
Thr Leu Thr Ala Glu Lys Thr Thr Leu Val 340 345 350 gtt aaa gaa gga
act gtt act tta agc aaa aat att tca aaa tct ggg 1104 Val Lys Glu
Gly Thr Val Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly 355 360 365 gaa
gtt tca gtt gaa ctt aat gac act gac agt agt gct gct act aaa 1152
Glu Val Ser Val Glu Leu Asn Asp Thr Asp Ser Ser Ala Ala Thr Lys 370
375 380 aaa act gca gct tgg aat tca ggc act tca act tta aca att act
gta 1200 Lys Thr Ala Ala Trp Asn Ser Gly Thr Ser Thr Leu Thr Ile
Thr Val 385 390 395 400 aac agt aaa aaa act aaa gac ctt gtg ttt aca
aaa gaa aac aca att 1248 Asn Ser Lys Lys Thr Lys Asp Leu Val Phe
Thr Lys Glu Asn Thr Ile 405 410 415 aca gta caa caa tac gac tca aat
ggc acc aaa tta gag ggg tca gca 1296 Thr Val Gln Gln Tyr Asp Ser
Asn Gly Thr Lys Leu Glu Gly Ser Ala 420 425 430 gtt gaa att aca aaa
ctt gat gaa att aaa aac gct tta aaa taa 1341 Val Glu Ile Thr Lys
Leu Asp Glu Ile Lys Asn Ala Leu Lys * 435 440 445 60 446 PRT
Artificial Sequence Chimeric protein 60 Met Ala Cys Asn Asn Ser Gly
Lys Asp Gly Asn Thr Ser Ala Asn Ser 1 5 10 15 Ala Asp Glu Ser Val
Lys Gly Pro Asn Leu Thr Glu Ile Ser Lys Lys 20 25 30 Ile Thr Asp
Ser Asn Ala Val Leu Leu Ala Val Lys Glu Val Glu Ala 35 40 45 Leu
Leu Ser Ser Ile Asp Glu Leu Ala Lys Ala Ile Gly Lys Lys Ile 50 55
60 Lys Asn Asp Gly Ser Leu Asp Asn Glu Ala Asn Arg Asn Glu Ser Leu
65 70 75 80 Leu Ala Gly Ala Tyr Thr Ile Ser Thr Leu Ile Thr Gln Lys
Leu Ser 85 90 95 Lys Leu Asn Gly Ser Glu Gly Leu Lys Glu Lys Ile
Ala Ala Ala Lys 100 105 110 Lys Cys Ser Glu Glu Phe Ser Thr Lys Leu
Lys Asp Asn His Ala Gln 115 120 125 Leu Gly Ile Gln Gly Val Thr Asp
Glu Asn Ala Lys Lys Ala Ile Leu 130 135 140 Lys Ala Asn Ala Ala Gly
Lys Asp Lys Gly Val Glu Glu Leu Glu Lys 145 150 155 160 Leu Ser Gly
Ser Leu Glu Ser Leu Ser Lys Ala Ala Lys Glu Met Leu 165 170 175 Ala
Asn Ser Val Lys Glu Leu Thr Ser Pro Val Val His Gly Lys Gln 180 185
190 Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro
195 200 205 Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys Asn Lys Asp
Gly Lys 210 215 220 Tyr Asp Leu Ile Ala Thr Val Asp Lys Leu Glu Leu
Lys Gly Thr Ser 225 230 235 240 Asp Lys Asn Asn Gly Ser Gly Val Leu
Glu Gly Val Lys Ala Asp Lys 245 250 255 Ser Lys Val Lys Leu Thr Ile
Ser Asp Asp Leu Gly Gln Thr Thr Leu 260 265 270 Glu Val Phe Lys Glu
Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr 275 280 285 Ser Lys Asp
Lys Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu 290 295 300 Val
Ser Glu Lys Ile Ile Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr 305 310
315 320 Thr Gly Ile Lys Ser Asp Gly Ser Gly Lys Ala Lys Glu Val Leu
Lys 325 330 335 Gly Tyr Val Leu Glu Gly Thr Leu Thr Ala Glu Lys Thr
Thr Leu Val 340 345 350 Val Lys Glu Gly Thr Val Thr Leu Ser Lys Asn
Ile Ser Lys Ser Gly 355 360 365 Glu Val Ser Val Glu Leu Asn Asp Thr
Asp Ser Ser Ala Ala Thr Lys 370 375 380 Lys Thr Ala Ala Trp Asn Ser
Gly Thr Ser Thr Leu Thr Ile Thr Val 385 390 395 400 Asn Ser Lys Lys
Thr Lys Asp Leu Val Phe Thr Lys Glu Asn Thr Ile 405 410 415 Thr Val
Gln Gln Tyr Asp Ser Asn Gly Thr Lys Leu Glu Gly Ser Ala 420 425 430
Val Glu Ile Thr Lys Leu Asp Glu Ile Lys Asn Ala Leu Lys 435 440 445
61 1362 DNA Artificial Sequence Chimeric nucleic acid 61 atg gct
tgt aat aat tca ggg aaa gat ggg aat aca tct gca aat tct 48 Met Ala
Cys Asn Asn Ser Gly Lys Asp Gly Asn Thr Ser Ala Asn Ser 1 5 10 15
gct gat gag tct gtt aaa ggg cct aat ctt aca gaa ata aat aaa aaa 96
Ala Asp Glu Ser Val Lys Gly Pro Asn Leu Thr Glu Ile Asn Lys Lys 20
25 30 att acg gat tct aat gcg gtt tta ctt gct gtg aaa gag gtt gaa
gcg 144 Ile Thr Asp Ser Asn Ala Val Leu Leu Ala Val Lys Glu Val Glu
Ala 35 40 45 ttg ctg tca tct ata gat gaa att gct gct aaa gct att
ggt aaa aaa 192 Leu Leu Ser Ser Ile Asp Glu Ile Ala Ala Lys Ala Ile
Gly Lys Lys 50 55 60 ata cac caa aat aat ggt ttg gat acc gaa aat
aat cac aat gga tca 240 Ile His Gln Asn Asn Gly Leu Asp Thr Glu Asn
Asn His Asn Gly Ser 65 70 75 80 ttg tta gcg gga gct tat gca ata tca
acc cta ata aaa caa aaa tta 288 Leu Leu Ala Gly Ala Tyr Ala Ile Ser
Thr Leu Ile Lys Gln Lys Leu 85 90 95 gat gga ttg aaa aat gaa gga
tta aag gaa aaa att gat gcg gct aag 336 Asp Gly Leu Lys Asn Glu Gly
Leu Lys Glu Lys Ile Asp Ala Ala Lys 100 105 110 aaa tgt tct gaa aca
ttt act aat aaa tta aaa gaa aaa cac aca gat 384 Lys Cys Ser Glu Thr
Phe Thr Asn Lys Leu Lys Glu Lys His Thr Asp 115 120 125 ctt ggt aaa
gaa ggt gtt act gat gct gat gca aaa gaa gcc att tta 432 Leu Gly Lys
Glu Gly Val Thr Asp Ala Asp Ala Lys Glu Ala Ile Leu 130 135 140 aaa
gca aat ggt act aaa act aaa ggt gct gaa gaa ctt gga aaa tta 480 Lys
Ala Asn Gly Thr Lys Thr Lys Gly Ala Glu Glu Leu Gly Lys Leu 145 150
155 160 ttt gaa tca gta gag gtc ttg tca aaa gca gct aaa gag atg ctt
gct 528 Phe Glu Ser Val Glu Val Leu Ser Lys Ala Ala Lys Glu Met Leu
Ala 165 170 175 aat tca gtt aaa gag ctt aca agc cct gtt gtg gca gaa
agt cca aaa 576 Asn Ser Val Lys Glu Leu Thr Ser Pro Val Val Ala Glu
Ser Pro Lys 180 185 190 aaa cct tcc atg gcc aag caa aat gtt agc agc
ctt gac gag aaa aac 624 Lys Pro Ser Met Ala Lys Gln Asn Val Ser Ser
Leu Asp Glu Lys Asn 195 200 205 agc gtt tca gta gat ttg cct ggt gaa
atg aaa gtt ctt gta agc aaa 672 Ser Val Ser Val Asp Leu Pro Gly Glu
Met Lys Val Leu Val Ser Lys 210 215 220 gaa aaa aac aaa gac ggc aag
tac gat cta att gca aca gta gac aag 720 Glu Lys Asn Lys Asp Gly Lys
Tyr Asp Leu Ile Ala Thr Val Asp Lys 225 230 235 240 ctt gag ctt aaa
gga act tct gat aaa aac aat gga tct gga gta ctt 768 Leu Glu Leu Lys
Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Val Leu 245 250 255 gaa ggc
gta aaa gct gac aaa agt aaa gta aaa tta aca att tct gac 816 Glu Gly
Val Lys Ala Asp Lys Ser Lys Val Lys Leu Thr Ile Ser Asp 260 265 270
gat cta ggt caa acc aca ctt gaa gtt ttc aaa gaa gat ggc aaa aca 864
Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys Glu Asp Gly Lys Thr 275
280 285 cta gta tca aaa aaa gta act tcc aaa gac aag tca tca aca gaa
gaa 912 Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys Ser Ser Thr Glu
Glu 290 295 300 aaa ttc aat gaa aaa ggt gaa gta tct gaa aaa ata ata
aca aga gca 960 Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys Ile Ile
Thr Arg Ala 305 310 315 320 gac gga acc aga ctt gaa tac aca gga att
aaa agc gat gga tct gga 1008 Asp Gly Thr Arg Leu Glu Tyr Thr Gly
Ile Lys Ser Asp Gly Ser Gly 325 330 335 aaa gct aaa gag gtt tta aaa
ggc tat gtt ctt gaa gga act cta act 1056 Lys Ala Lys Glu Val Leu
Lys Gly Tyr Val Leu Glu Gly Thr Leu Thr 340 345 350 gct gaa aaa aca
aca ttg gtg gtt aaa gaa gga act gtt act tta agc 1104 Ala Glu Lys
Thr Thr Leu Val Val Lys Glu Gly Thr Val Thr Leu Ser 355 360 365 aaa
aat att tca aaa tct ggg gaa gtt tca gtt gaa ctt aat gac act 1152
Lys Asn Ile Ser Lys Ser Gly Glu Val Ser Val Glu Leu Asn Asp Thr 370
375 380 gac agt agt gct gct act aaa aaa act gca gct tgg aat tca aaa
act 1200 Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala Trp Asn Ser
Lys Thr 385 390 395 400 tcc act tta aca att agt gtg aat agc caa aaa
acc aaa aac ctt gta 1248 Ser Thr Leu Thr Ile Ser Val Asn Ser Gln
Lys Thr Lys Asn Leu Val 405 410 415 ttc aca aaa gaa gac aca ata aca
gta caa aaa tac gac tca gca ggc 1296 Phe Thr Lys Glu Asp Thr Ile
Thr Val Gln Lys Tyr Asp Ser Ala Gly 420 425 430 acc aat cta gaa ggc
aaa gca gtc gaa att aca aca ctt aaa gaa ctt 1344 Thr Asn Leu Glu
Gly Lys Ala Val Glu Ile Thr Thr Leu Lys Glu Leu 435 440 445 aaa aac
gct tta aaa taa
1362 Lys Asn Ala Leu Lys * 450 62 453 PRT Artificial Sequence
Chimeric protein 62 Met Ala Cys Asn Asn Ser Gly Lys Asp Gly Asn Thr
Ser Ala Asn Ser 1 5 10 15 Ala Asp Glu Ser Val Lys Gly Pro Asn Leu
Thr Glu Ile Asn Lys Lys 20 25 30 Ile Thr Asp Ser Asn Ala Val Leu
Leu Ala Val Lys Glu Val Glu Ala 35 40 45 Leu Leu Ser Ser Ile Asp
Glu Ile Ala Ala Lys Ala Ile Gly Lys Lys 50 55 60 Ile His Gln Asn
Asn Gly Leu Asp Thr Glu Asn Asn His Asn Gly Ser 65 70 75 80 Leu Leu
Ala Gly Ala Tyr Ala Ile Ser Thr Leu Ile Lys Gln Lys Leu 85 90 95
Asp Gly Leu Lys Asn Glu Gly Leu Lys Glu Lys Ile Asp Ala Ala Lys 100
105 110 Lys Cys Ser Glu Thr Phe Thr Asn Lys Leu Lys Glu Lys His Thr
Asp 115 120 125 Leu Gly Lys Glu Gly Val Thr Asp Ala Asp Ala Lys Glu
Ala Ile Leu 130 135 140 Lys Ala Asn Gly Thr Lys Thr Lys Gly Ala Glu
Glu Leu Gly Lys Leu 145 150 155 160 Phe Glu Ser Val Glu Val Leu Ser
Lys Ala Ala Lys Glu Met Leu Ala 165 170 175 Asn Ser Val Lys Glu Leu
Thr Ser Pro Val Val Ala Glu Ser Pro Lys 180 185 190 Lys Pro Ser Met
Ala Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn 195 200 205 Ser Val
Ser Val Asp Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys 210 215 220
Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu Ile Ala Thr Val Asp Lys 225
230 235 240 Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly
Val Leu 245 250 255 Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys Leu
Thr Ile Ser Asp 260 265 270 Asp Leu Gly Gln Thr Thr Leu Glu Val Phe
Lys Glu Asp Gly Lys Thr 275 280 285 Leu Val Ser Lys Lys Val Thr Ser
Lys Asp Lys Ser Ser Thr Glu Glu 290 295 300 Lys Phe Asn Glu Lys Gly
Glu Val Ser Glu Lys Ile Ile Thr Arg Ala 305 310 315 320 Asp Gly Thr
Arg Leu Glu Tyr Thr Gly Ile Lys Ser Asp Gly Ser Gly 325 330 335 Lys
Ala Lys Glu Val Leu Lys Gly Tyr Val Leu Glu Gly Thr Leu Thr 340 345
350 Ala Glu Lys Thr Thr Leu Val Val Lys Glu Gly Thr Val Thr Leu Ser
355 360 365 Lys Asn Ile Ser Lys Ser Gly Glu Val Ser Val Glu Leu Asn
Asp Thr 370 375 380 Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala Trp
Asn Ser Lys Thr 385 390 395 400 Ser Thr Leu Thr Ile Ser Val Asn Ser
Gln Lys Thr Lys Asn Leu Val 405 410 415 Phe Thr Lys Glu Asp Thr Ile
Thr Val Gln Lys Tyr Asp Ser Ala Gly 420 425 430 Thr Asn Leu Glu Gly
Lys Ala Val Glu Ile Thr Thr Leu Lys Glu Leu 435 440 445 Lys Asn Ala
Leu Lys 450 63 1341 DNA Artificial Sequence Chimeric nucleic acid
63 atg gct tgt aat aat tca ggg aaa gat ggg aat aca tct gca aat tct
48 Met Ala Cys Asn Asn Ser Gly Lys Asp Gly Asn Thr Ser Ala Asn Ser
1 5 10 15 gct gat gag tct gtt aaa ggg cct aat ctt aca gaa ata agt
aaa aaa 96 Ala Asp Glu Ser Val Lys Gly Pro Asn Leu Thr Glu Ile Ser
Lys Lys 20 25 30 att acg gat tct aat gcg gtt tta ctt gct gtg aaa
gag gtt gaa gcg 144 Ile Thr Asp Ser Asn Ala Val Leu Leu Ala Val Lys
Glu Val Glu Ala 35 40 45 ttg ctg tca tct ata gat gag ctt gct aaa
gct att ggt aaa aaa ata 192 Leu Leu Ser Ser Ile Asp Glu Leu Ala Lys
Ala Ile Gly Lys Lys Ile 50 55 60 aaa aac gat ggt agt tta gat aat
gaa gca aat cgc aac gag tca ttg 240 Lys Asn Asp Gly Ser Leu Asp Asn
Glu Ala Asn Arg Asn Glu Ser Leu 65 70 75 80 tta gca gga gct tat aca
ata tca acc tta ata aca caa aaa tta agt 288 Leu Ala Gly Ala Tyr Thr
Ile Ser Thr Leu Ile Thr Gln Lys Leu Ser 85 90 95 aaa tta aac gga
tca gaa ggt tta aag gaa aag att gcc gca gct aag 336 Lys Leu Asn Gly
Ser Glu Gly Leu Lys Glu Lys Ile Ala Ala Ala Lys 100 105 110 aaa tgc
tct gaa gag ttt agt act aaa cta aaa gat aat cat gca cag 384 Lys Cys
Ser Glu Glu Phe Ser Thr Lys Leu Lys Asp Asn His Ala Gln 115 120 125
ctt ggt ata cag ggc gtt act gat gaa aat gca aaa aaa gct att tta 432
Leu Gly Ile Gln Gly Val Thr Asp Glu Asn Ala Lys Lys Ala Ile Leu 130
135 140 aaa gca aat gca gcg ggt aaa gat aag ggc gtt gaa gaa ctt gaa
aag 480 Lys Ala Asn Ala Ala Gly Lys Asp Lys Gly Val Glu Glu Leu Glu
Lys 145 150 155 160 ttg tcc gga tca tta gaa agc tta tca aaa gca gct
aaa gag atg ctt 528 Leu Ser Gly Ser Leu Glu Ser Leu Ser Lys Ala Ala
Lys Glu Met Leu 165 170 175 gct aat tca gtt aaa gag ctt aca agc cct
gtt gtc cat ggc aag caa 576 Ala Asn Ser Val Lys Glu Leu Thr Ser Pro
Val Val His Gly Lys Gln 180 185 190 aat gtt agc agc ctt gac gag aaa
aac agc gtt tca gta gat ttg cct 624 Asn Val Ser Ser Leu Asp Glu Lys
Asn Ser Val Ser Val Asp Leu Pro 195 200 205 ggt gaa atg aaa gtt ctt
gta agc aaa gaa aaa aac aaa gac ggc aag 672 Gly Glu Met Lys Val Leu
Val Ser Lys Glu Lys Asn Lys Asp Gly Lys 210 215 220 tac gat cta att
gca aca gta gac aag ctt gag ctt aaa gga act tct 720 Tyr Asp Leu Ile
Ala Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser 225 230 235 240 gat
aaa aac aat gga tct gga gta ctt gaa ggc gta aaa gct gac aaa 768 Asp
Lys Asn Asn Gly Ser Gly Val Leu Glu Gly Val Lys Ala Asp Lys 245 250
255 agt aaa gta aaa tta aca att tct gac gat cta ggt caa acc aca ctt
816 Ser Lys Val Lys Leu Thr Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu
260 265 270 gaa gtt ttc aaa gaa gat ggc aaa aca cta gta tca aaa aaa
gta act 864 Glu Val Phe Lys Glu Asp Gly Lys Thr Leu Val Ser Lys Lys
Val Thr 275 280 285 tcc aaa gac aag tca tca aca gaa gaa aaa ttc aat
gaa aaa ggt gaa 912 Ser Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn
Glu Lys Gly Glu 290 295 300 gta tct gaa aaa ata ata aca aga gca gac
gga acc aga ctt gaa tac 960 Val Ser Glu Lys Ile Ile Thr Arg Ala Asp
Gly Thr Arg Leu Glu Tyr 305 310 315 320 aca gga att aaa agc gat gga
tct gga aaa gct aaa gag gtt tta aaa 1008 Thr Gly Ile Lys Ser Asp
Gly Ser Gly Lys Ala Lys Glu Val Leu Lys 325 330 335 ggc tat gtt ctt
gaa gga act cta act gct gaa aaa aca aca ttg gtg 1056 Gly Tyr Val
Leu Glu Gly Thr Leu Thr Ala Glu Lys Thr Thr Leu Val 340 345 350 gtt
aaa gaa gga act gtt act tta agc aaa aat att tca aaa tct ggg 1104
Val Lys Glu Gly Thr Val Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly 355
360 365 gaa gtt tca gtt gaa ctt aat gac act gac agt agt gct gct act
aaa 1152 Glu Val Ser Val Glu Leu Asn Asp Thr Asp Ser Ser Ala Ala
Thr Lys 370 375 380 aaa act gca gct tgg aat tca aaa act tcc act tta
aca att agt gtg 1200 Lys Thr Ala Ala Trp Asn Ser Lys Thr Ser Thr
Leu Thr Ile Ser Val 385 390 395 400 aat agc caa aaa acc aaa aac ctt
gta ttc aca aaa gaa gac aca ata 1248 Asn Ser Gln Lys Thr Lys Asn
Leu Val Phe Thr Lys Glu Asp Thr Ile 405 410 415 aca gta caa aaa tac
gac tca gca ggc acc aat cta gaa ggc aaa gca 1296 Thr Val Gln Lys
Tyr Asp Ser Ala Gly Thr Asn Leu Glu Gly Lys Ala 420 425 430 gtc gaa
att aca aca ctt aaa gaa ctt aaa aac gct tta aaa taa 1341 Val Glu
Ile Thr Thr Leu Lys Glu Leu Lys Asn Ala Leu Lys * 435 440 445 64
446 PRT Artificial Sequence Chimeric protein 64 Met Ala Cys Asn Asn
Ser Gly Lys Asp Gly Asn Thr Ser Ala Asn Ser 1 5 10 15 Ala Asp Glu
Ser Val Lys Gly Pro Asn Leu Thr Glu Ile Ser Lys Lys 20 25 30 Ile
Thr Asp Ser Asn Ala Val Leu Leu Ala Val Lys Glu Val Glu Ala 35 40
45 Leu Leu Ser Ser Ile Asp Glu Leu Ala Lys Ala Ile Gly Lys Lys Ile
50 55 60 Lys Asn Asp Gly Ser Leu Asp Asn Glu Ala Asn Arg Asn Glu
Ser Leu 65 70 75 80 Leu Ala Gly Ala Tyr Thr Ile Ser Thr Leu Ile Thr
Gln Lys Leu Ser 85 90 95 Lys Leu Asn Gly Ser Glu Gly Leu Lys Glu
Lys Ile Ala Ala Ala Lys 100 105 110 Lys Cys Ser Glu Glu Phe Ser Thr
Lys Leu Lys Asp Asn His Ala Gln 115 120 125 Leu Gly Ile Gln Gly Val
Thr Asp Glu Asn Ala Lys Lys Ala Ile Leu 130 135 140 Lys Ala Asn Ala
Ala Gly Lys Asp Lys Gly Val Glu Glu Leu Glu Lys 145 150 155 160 Leu
Ser Gly Ser Leu Glu Ser Leu Ser Lys Ala Ala Lys Glu Met Leu 165 170
175 Ala Asn Ser Val Lys Glu Leu Thr Ser Pro Val Val His Gly Lys Gln
180 185 190 Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val Ser Val Asp
Leu Pro 195 200 205 Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys Asn
Lys Asp Gly Lys 210 215 220 Tyr Asp Leu Ile Ala Thr Val Asp Lys Leu
Glu Leu Lys Gly Thr Ser 225 230 235 240 Asp Lys Asn Asn Gly Ser Gly
Val Leu Glu Gly Val Lys Ala Asp Lys 245 250 255 Ser Lys Val Lys Leu
Thr Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu 260 265 270 Glu Val Phe
Lys Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr 275 280 285 Ser
Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu 290 295
300 Val Ser Glu Lys Ile Ile Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr
305 310 315 320 Thr Gly Ile Lys Ser Asp Gly Ser Gly Lys Ala Lys Glu
Val Leu Lys 325 330 335 Gly Tyr Val Leu Glu Gly Thr Leu Thr Ala Glu
Lys Thr Thr Leu Val 340 345 350 Val Lys Glu Gly Thr Val Thr Leu Ser
Lys Asn Ile Ser Lys Ser Gly 355 360 365 Glu Val Ser Val Glu Leu Asn
Asp Thr Asp Ser Ser Ala Ala Thr Lys 370 375 380 Lys Thr Ala Ala Trp
Asn Ser Lys Thr Ser Thr Leu Thr Ile Ser Val 385 390 395 400 Asn Ser
Gln Lys Thr Lys Asn Leu Val Phe Thr Lys Glu Asp Thr Ile 405 410 415
Thr Val Gln Lys Tyr Asp Ser Ala Gly Thr Asn Leu Glu Gly Lys Ala 420
425 430 Val Glu Ile Thr Thr Leu Lys Glu Leu Lys Asn Ala Leu Lys 435
440 445 65 1362 DNA Artificial Sequence Chimeric nucleic acid 65
atg gct tgt aat aat tca ggg aaa gat ggg aat aca tct gca aat tct 48
Met Ala Cys Asn Asn Ser Gly Lys Asp Gly Asn Thr Ser Ala Asn Ser 1 5
10 15 gct gat gag tct gtt aaa ggg cct aat ctt aca gaa ata aat aaa
aaa 96 Ala Asp Glu Ser Val Lys Gly Pro Asn Leu Thr Glu Ile Asn Lys
Lys 20 25 30 att acg tca tct aat gcg gtt tta ctt gct gtg aaa gag
gtt gaa gcg 144 Ile Thr Ser Ser Asn Ala Val Leu Leu Ala Val Lys Glu
Val Glu Ala 35 40 45 ttg ctg gat tct ata gat gaa att gct gct aaa
gct att ggt aaa aaa 192 Leu Leu Asp Ser Ile Asp Glu Ile Ala Ala Lys
Ala Ile Gly Lys Lys 50 55 60 ata cac caa aat aat ggt ttg gat acc
gaa aat aat cac aat gga tca 240 Ile His Gln Asn Asn Gly Leu Asp Thr
Glu Asn Asn His Asn Gly Ser 65 70 75 80 ttg tta gcg gga gct tat gca
ata tca acc cta ata aaa caa aaa tta 288 Leu Leu Ala Gly Ala Tyr Ala
Ile Ser Thr Leu Ile Lys Gln Lys Leu 85 90 95 gat gga ttg aaa aat
gaa gga tta aag gaa aaa att gat gcg gct aag 336 Asp Gly Leu Lys Asn
Glu Gly Leu Lys Glu Lys Ile Asp Ala Ala Lys 100 105 110 aaa tgt tct
gaa aca ttt act aat aaa tta aaa gaa aaa cac aca gat 384 Lys Cys Ser
Glu Thr Phe Thr Asn Lys Leu Lys Glu Lys His Thr Asp 115 120 125 ctt
ggt aaa gaa ggt gtt act gat gct gat gca aaa gaa gcc att tta 432 Leu
Gly Lys Glu Gly Val Thr Asp Ala Asp Ala Lys Glu Ala Ile Leu 130 135
140 aaa gca aat ggt act aaa act aaa ggt gct gaa gaa ctt gga aaa tta
480 Lys Ala Asn Gly Thr Lys Thr Lys Gly Ala Glu Glu Leu Gly Lys Leu
145 150 155 160 ttt gaa tca gta gag gtc ttg tca aaa gca gct aaa gag
atg ctt gct 528 Phe Glu Ser Val Glu Val Leu Ser Lys Ala Ala Lys Glu
Met Leu Ala 165 170 175 aat tca gtt aaa gag ctt aca agc cct gtt gtg
gca gaa agt cca aaa 576 Asn Ser Val Lys Glu Leu Thr Ser Pro Val Val
Ala Glu Ser Pro Lys 180 185 190 aaa cct tcc atg gcc aag caa aat gtt
agc agc ctt gac gag aaa aac 624 Lys Pro Ser Met Ala Lys Gln Asn Val
Ser Ser Leu Asp Glu Lys Asn 195 200 205 agc gtt tca gta gat ttg cct
ggt gaa atg aaa gtt ctt gta agc aaa 672 Ser Val Ser Val Asp Leu Pro
Gly Glu Met Lys Val Leu Val Ser Lys 210 215 220 gaa aaa aac aaa gac
ggc aag tac gat cta att gca aca gta gac aag 720 Glu Lys Asn Lys Asp
Gly Lys Tyr Asp Leu Ile Ala Thr Val Asp Lys 225 230 235 240 ctt gag
ctt aaa gga act tct gat aaa aac aat gga tct gga gta ctt 768 Leu Glu
Leu Lys Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Val Leu 245 250 255
gaa ggc gta aaa gct gac aaa agt aaa gta aaa tta aca att tct gac 816
Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys Leu Thr Ile Ser Asp 260
265 270 gat cta ggt caa acc aca ctt gaa gtt ttc aaa gaa gat ggc aaa
aca 864 Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys Glu Asp Gly Lys
Thr 275 280 285 cta gta tca aaa aaa gta act tcc aaa gac aag tca tca
aca gaa gaa 912 Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys Ser Ser
Thr Glu Glu 290 295 300 aaa ttc aat gaa aaa ggt gaa gta tct gaa aaa
ata ata aca aga gca 960 Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys
Ile Ile Thr Arg Ala 305 310 315 320 gac gga acc aga ctt gaa tac aca
gga att aaa agc gat gga tct gga 1008 Asp Gly Thr Arg Leu Glu Tyr
Thr Gly Ile Lys Ser Asp Gly Ser Gly 325 330 335 aaa gct aaa gag gtt
tta aaa ggc tat gtt ctt gaa gga act cta act 1056 Lys Ala Lys Glu
Val Leu Lys Gly Tyr Val Leu Glu Gly Thr Leu Thr 340 345 350 gct gaa
aaa aca aca ttg gtg gtt aaa gaa gga act gtt act tta agc 1104 Ala
Glu Lys Thr Thr Leu Val Val Lys Glu Gly Thr Val Thr Leu Ser 355 360
365 aaa aat att tca aaa tct ggg gaa gtt tca gtt gaa ctt aat gac act
1152 Lys Asn Ile Ser Lys Ser Gly Glu Val Ser Val Glu Leu Asn Asp
Thr 370 375 380 gac agt agt gct gct act aaa aaa act gca gct tgg aat
tca aaa act 1200 Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala Trp
Asn Ser Lys Thr 385 390 395 400 tct act tta aca att agt gtt aac agc
aaa aaa act aca caa ctt gtg 1248 Ser Thr Leu Thr Ile Ser Val Asn
Ser Lys Lys Thr Thr Gln Leu Val 405 410 415 ttt act aaa caa gac aca
ata act gta caa aaa tac gac tcc gca ggt 1296 Phe Thr Lys Gln Asp
Thr Ile Thr Val Gln Lys Tyr Asp Ser Ala Gly 420 425 430 acc aat tta
gaa ggc aca gca gtc gaa att aaa aca ctt gat gaa ctt 1344 Thr Asn
Leu Glu Gly Thr Ala Val Glu Ile Lys Thr Leu Asp Glu Leu 435 440 445
aaa aac gct tta aaa taa 1362 Lys Asn Ala Leu Lys * 450 66 453 PRT
Artificial Sequence Chimeric protein 66 Met Ala Cys Asn Asn Ser Gly
Lys Asp Gly Asn Thr Ser Ala Asn Ser 1 5 10 15 Ala Asp Glu Ser Val
Lys Gly Pro Asn Leu Thr Glu Ile Asn Lys Lys 20 25 30 Ile Thr Ser
Ser Asn Ala Val Leu Leu Ala Val Lys Glu Val Glu Ala 35 40 45 Leu
Leu Asp Ser Ile Asp Glu Ile Ala Ala Lys Ala Ile Gly
Lys Lys 50 55 60 Ile His Gln Asn Asn Gly Leu Asp Thr Glu Asn Asn
His Asn Gly Ser 65 70 75 80 Leu Leu Ala Gly Ala Tyr Ala Ile Ser Thr
Leu Ile Lys Gln Lys Leu 85 90 95 Asp Gly Leu Lys Asn Glu Gly Leu
Lys Glu Lys Ile Asp Ala Ala Lys 100 105 110 Lys Cys Ser Glu Thr Phe
Thr Asn Lys Leu Lys Glu Lys His Thr Asp 115 120 125 Leu Gly Lys Glu
Gly Val Thr Asp Ala Asp Ala Lys Glu Ala Ile Leu 130 135 140 Lys Ala
Asn Gly Thr Lys Thr Lys Gly Ala Glu Glu Leu Gly Lys Leu 145 150 155
160 Phe Glu Ser Val Glu Val Leu Ser Lys Ala Ala Lys Glu Met Leu Ala
165 170 175 Asn Ser Val Lys Glu Leu Thr Ser Pro Val Val Ala Glu Ser
Pro Lys 180 185 190 Lys Pro Ser Met Ala Lys Gln Asn Val Ser Ser Leu
Asp Glu Lys Asn 195 200 205 Ser Val Ser Val Asp Leu Pro Gly Glu Met
Lys Val Leu Val Ser Lys 210 215 220 Glu Lys Asn Lys Asp Gly Lys Tyr
Asp Leu Ile Ala Thr Val Asp Lys 225 230 235 240 Leu Glu Leu Lys Gly
Thr Ser Asp Lys Asn Asn Gly Ser Gly Val Leu 245 250 255 Glu Gly Val
Lys Ala Asp Lys Ser Lys Val Lys Leu Thr Ile Ser Asp 260 265 270 Asp
Leu Gly Gln Thr Thr Leu Glu Val Phe Lys Glu Asp Gly Lys Thr 275 280
285 Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys Ser Ser Thr Glu Glu
290 295 300 Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys Ile Ile Thr
Arg Ala 305 310 315 320 Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys
Ser Asp Gly Ser Gly 325 330 335 Lys Ala Lys Glu Val Leu Lys Gly Tyr
Val Leu Glu Gly Thr Leu Thr 340 345 350 Ala Glu Lys Thr Thr Leu Val
Val Lys Glu Gly Thr Val Thr Leu Ser 355 360 365 Lys Asn Ile Ser Lys
Ser Gly Glu Val Ser Val Glu Leu Asn Asp Thr 370 375 380 Asp Ser Ser
Ala Ala Thr Lys Lys Thr Ala Ala Trp Asn Ser Lys Thr 385 390 395 400
Ser Thr Leu Thr Ile Ser Val Asn Ser Lys Lys Thr Thr Gln Leu Val 405
410 415 Phe Thr Lys Gln Asp Thr Ile Thr Val Gln Lys Tyr Asp Ser Ala
Gly 420 425 430 Thr Asn Leu Glu Gly Thr Ala Val Glu Ile Lys Thr Leu
Asp Glu Leu 435 440 445 Lys Asn Ala Leu Lys 450 67 1341 DNA
Artificial Sequence Chimeric nucleic acid 67 atg gct tgt aat aat
tca ggg aaa gat ggg aat aca tct gca aat tct 48 Met Ala Cys Asn Asn
Ser Gly Lys Asp Gly Asn Thr Ser Ala Asn Ser 1 5 10 15 gct gat gag
tct gtt aaa ggg cct aat ctt aca gaa ata agt aaa aaa 96 Ala Asp Glu
Ser Val Lys Gly Pro Asn Leu Thr Glu Ile Ser Lys Lys 20 25 30 att
acg gat tct aat gcg gtt tta ctt gct gtg aaa gag gtt gaa gcg 144 Ile
Thr Asp Ser Asn Ala Val Leu Leu Ala Val Lys Glu Val Glu Ala 35 40
45 ttg ctg tca tct ata gat gag ctt gct aaa gct att ggt aaa aaa ata
192 Leu Leu Ser Ser Ile Asp Glu Leu Ala Lys Ala Ile Gly Lys Lys Ile
50 55 60 aaa aac gat ggt agt tta gat aat gaa gca aat cgc aac gag
tca ttg 240 Lys Asn Asp Gly Ser Leu Asp Asn Glu Ala Asn Arg Asn Glu
Ser Leu 65 70 75 80 tta gca gga gct tat aca ata tca acc tta ata aca
caa aaa tta agt 288 Leu Ala Gly Ala Tyr Thr Ile Ser Thr Leu Ile Thr
Gln Lys Leu Ser 85 90 95 aaa tta aac gga tca gaa ggt tta aag gaa
aag att gcc gca gct aag 336 Lys Leu Asn Gly Ser Glu Gly Leu Lys Glu
Lys Ile Ala Ala Ala Lys 100 105 110 aaa tgc tct gaa gag ttt agt act
aaa cta aaa gat aat cat gca cag 384 Lys Cys Ser Glu Glu Phe Ser Thr
Lys Leu Lys Asp Asn His Ala Gln 115 120 125 ctt ggt ata cag ggc gtt
act gat gaa aat gca aaa aaa gct att tta 432 Leu Gly Ile Gln Gly Val
Thr Asp Glu Asn Ala Lys Lys Ala Ile Leu 130 135 140 aaa gca aat gca
gcg ggt aaa gat aag ggc gtt gaa gaa ctt gaa aag 480 Lys Ala Asn Ala
Ala Gly Lys Asp Lys Gly Val Glu Glu Leu Glu Lys 145 150 155 160 ttg
tcc gga tca tta gaa agc tta tca aaa gca gct aaa gag atg ctt 528 Leu
Ser Gly Ser Leu Glu Ser Leu Ser Lys Ala Ala Lys Glu Met Leu 165 170
175 gct aat tca gtt aaa gag ctt aca agc cct gtt gtc cat ggc aag caa
576 Ala Asn Ser Val Lys Glu Leu Thr Ser Pro Val Val His Gly Lys Gln
180 185 190 aat gtt agc agc ctt gac gag aaa aac agc gtt tca gta gat
ttg cct 624 Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val Ser Val Asp
Leu Pro 195 200 205 ggt gaa atg aaa gtt ctt gta agc aaa gaa aaa aac
aaa gac ggc aag 672 Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys Asn
Lys Asp Gly Lys 210 215 220 tac gat cta att gca aca gta gac aag ctt
gag ctt aaa gga act tct 720 Tyr Asp Leu Ile Ala Thr Val Asp Lys Leu
Glu Leu Lys Gly Thr Ser 225 230 235 240 gat aaa aac aat gga tct gga
gta ctt gaa ggc gta aaa gct gac aaa 768 Asp Lys Asn Asn Gly Ser Gly
Val Leu Glu Gly Val Lys Ala Asp Lys 245 250 255 agt aaa gta aaa tta
aca att tct gac gat cta ggt caa acc aca ctt 816 Ser Lys Val Lys Leu
Thr Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu 260 265 270 gaa gtt ttc
aaa gaa gat ggc aaa aca cta gta tca aaa aaa gta act 864 Glu Val Phe
Lys Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr 275 280 285 tcc
aaa gac aag tca tca aca gaa gaa aaa ttc aat gaa aaa ggt gaa 912 Ser
Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu 290 295
300 gta tct gaa aaa ata ata aca aga gca gac gga acc aga ctt gaa tac
960 Val Ser Glu Lys Ile Ile Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr
305 310 315 320 aca gga att aaa agc gat gga tct gga aaa gct aaa gag
gtt tta aaa 1008 Thr Gly Ile Lys Ser Asp Gly Ser Gly Lys Ala Lys
Glu Val Leu Lys 325 330 335 ggc tat gtt ctt gaa gga act cta act gct
gaa aaa aca aca ttg gtg 1056 Gly Tyr Val Leu Glu Gly Thr Leu Thr
Ala Glu Lys Thr Thr Leu Val 340 345 350 gtt aaa gaa gga act gtt act
tta agc aaa aat att tca aaa tct ggg 1104 Val Lys Glu Gly Thr Val
Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly 355 360 365 gaa gtt tca gtt
gaa ctt aat gac act gac agt agt gct gct act aaa 1152 Glu Val Ser
Val Glu Leu Asn Asp Thr Asp Ser Ser Ala Ala Thr Lys 370 375 380 aaa
act gca gct tgg aat tca aaa act tct act tta aca att agt gtt 1200
Lys Thr Ala Ala Trp Asn Ser Lys Thr Ser Thr Leu Thr Ile Ser Val 385
390 395 400 aac agc aaa aaa act aca caa ctt gtg ttt act aaa caa tac
aca ata 1248 Asn Ser Lys Lys Thr Thr Gln Leu Val Phe Thr Lys Gln
Tyr Thr Ile 405 410 415 act gta aaa caa tac gac tcc gca ggt acc aat
tta gaa ggc aca gca 1296 Thr Val Lys Gln Tyr Asp Ser Ala Gly Thr
Asn Leu Glu Gly Thr Ala 420 425 430 gtc gaa att aaa aca ctt gat gaa
ctt aaa aac gct tta aaa taa 1341 Val Glu Ile Lys Thr Leu Asp Glu
Leu Lys Asn Ala Leu Lys * 435 440 445 68 446 PRT Artificial
Sequence Chimeric protein 68 Met Ala Cys Asn Asn Ser Gly Lys Asp
Gly Asn Thr Ser Ala Asn Ser 1 5 10 15 Ala Asp Glu Ser Val Lys Gly
Pro Asn Leu Thr Glu Ile Ser Lys Lys 20 25 30 Ile Thr Asp Ser Asn
Ala Val Leu Leu Ala Val Lys Glu Val Glu Ala 35 40 45 Leu Leu Ser
Ser Ile Asp Glu Leu Ala Lys Ala Ile Gly Lys Lys Ile 50 55 60 Lys
Asn Asp Gly Ser Leu Asp Asn Glu Ala Asn Arg Asn Glu Ser Leu 65 70
75 80 Leu Ala Gly Ala Tyr Thr Ile Ser Thr Leu Ile Thr Gln Lys Leu
Ser 85 90 95 Lys Leu Asn Gly Ser Glu Gly Leu Lys Glu Lys Ile Ala
Ala Ala Lys 100 105 110 Lys Cys Ser Glu Glu Phe Ser Thr Lys Leu Lys
Asp Asn His Ala Gln 115 120 125 Leu Gly Ile Gln Gly Val Thr Asp Glu
Asn Ala Lys Lys Ala Ile Leu 130 135 140 Lys Ala Asn Ala Ala Gly Lys
Asp Lys Gly Val Glu Glu Leu Glu Lys 145 150 155 160 Leu Ser Gly Ser
Leu Glu Ser Leu Ser Lys Ala Ala Lys Glu Met Leu 165 170 175 Ala Asn
Ser Val Lys Glu Leu Thr Ser Pro Val Val His Gly Lys Gln 180 185 190
Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val Ser Val Asp Leu Pro 195
200 205 Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys Asn Lys Asp Gly
Lys 210 215 220 Tyr Asp Leu Ile Ala Thr Val Asp Lys Leu Glu Leu Lys
Gly Thr Ser 225 230 235 240 Asp Lys Asn Asn Gly Ser Gly Val Leu Glu
Gly Val Lys Ala Asp Lys 245 250 255 Ser Lys Val Lys Leu Thr Ile Ser
Asp Asp Leu Gly Gln Thr Thr Leu 260 265 270 Glu Val Phe Lys Glu Asp
Gly Lys Thr Leu Val Ser Lys Lys Val Thr 275 280 285 Ser Lys Asp Lys
Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu 290 295 300 Val Ser
Glu Lys Ile Ile Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr 305 310 315
320 Thr Gly Ile Lys Ser Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys
325 330 335 Gly Tyr Val Leu Glu Gly Thr Leu Thr Ala Glu Lys Thr Thr
Leu Val 340 345 350 Val Lys Glu Gly Thr Val Thr Leu Ser Lys Asn Ile
Ser Lys Ser Gly 355 360 365 Glu Val Ser Val Glu Leu Asn Asp Thr Asp
Ser Ser Ala Ala Thr Lys 370 375 380 Lys Thr Ala Ala Trp Asn Ser Lys
Thr Ser Thr Leu Thr Ile Ser Val 385 390 395 400 Asn Ser Lys Lys Thr
Thr Gln Leu Val Phe Thr Lys Gln Tyr Thr Ile 405 410 415 Thr Val Lys
Gln Tyr Asp Ser Ala Gly Thr Asn Leu Glu Gly Thr Ala 420 425 430 Val
Glu Ile Lys Thr Leu Asp Glu Leu Lys Asn Ala Leu Lys 435 440 445 69
1365 DNA Artificial Sequence Chimeric nucleic acid 69 atg gct tgt
aat aat tca ggg aaa gat ggg aat aca tct gca aat tct 48 Met Ala Cys
Asn Asn Ser Gly Lys Asp Gly Asn Thr Ser Ala Asn Ser 1 5 10 15 gct
gat gag tct gtt aaa ggg cct aat ctt aca gaa ata agt aaa aaa 96 Ala
Asp Glu Ser Val Lys Gly Pro Asn Leu Thr Glu Ile Ser Lys Lys 20 25
30 att acg gat tct aat gcg gtt tta ctt gct gtg aaa gag gtt gaa gcg
144 Ile Thr Asp Ser Asn Ala Val Leu Leu Ala Val Lys Glu Val Glu Ala
35 40 45 ttg ctg tca tct ata gat gaa att gct gct aaa gct att ggt
aaa aaa 192 Leu Leu Ser Ser Ile Asp Glu Ile Ala Ala Lys Ala Ile Gly
Lys Lys 50 55 60 ata cac caa aat aat ggt ttg gat acc gaa tat aat
cac aat gga tca 240 Ile His Gln Asn Asn Gly Leu Asp Thr Glu Tyr Asn
His Asn Gly Ser 65 70 75 80 ttg tta gcg gga gct tat gca ata tca acc
cta ata aaa caa aaa tta 288 Leu Leu Ala Gly Ala Tyr Ala Ile Ser Thr
Leu Ile Lys Gln Lys Leu 85 90 95 gat gga ttg aaa aat gaa gga tta
aag gaa aaa att gat gcg gct aag 336 Asp Gly Leu Lys Asn Glu Gly Leu
Lys Glu Lys Ile Asp Ala Ala Lys 100 105 110 aaa tgt tct gaa aca ttt
act aat aaa tta aaa gaa aaa cac aca gat 384 Lys Cys Ser Glu Thr Phe
Thr Asn Lys Leu Lys Glu Lys His Thr Asp 115 120 125 ctt ggt aaa gaa
ggt gtt act gat gct gat gca aaa gaa gcc att tta 432 Leu Gly Lys Glu
Gly Val Thr Asp Ala Asp Ala Lys Glu Ala Ile Leu 130 135 140 aaa aca
aat ggt act aaa act aaa ggt gct gaa gaa ctt gga aaa tta 480 Lys Thr
Asn Gly Thr Lys Thr Lys Gly Ala Glu Glu Leu Gly Lys Leu 145 150 155
160 ttt gaa tca gta gag gtc ttg tca aaa gca gct aaa gag atg ctt gct
528 Phe Glu Ser Val Glu Val Leu Ser Lys Ala Ala Lys Glu Met Leu Ala
165 170 175 aat tca gtt aaa gag ctt aca agc cct gtt gtg gca gaa agt
cca aaa 576 Asn Ser Val Lys Glu Leu Thr Ser Pro Val Val Ala Glu Ser
Pro Lys 180 185 190 aaa cct tcc atg gcc aag caa aat gtt agc agc ctt
gat gaa aaa aat 624 Lys Pro Ser Met Ala Lys Gln Asn Val Ser Ser Leu
Asp Glu Lys Asn 195 200 205 agc gtt tca gta gat tta cct ggt gga atg
aca gtt ctt gta agt aaa 672 Ser Val Ser Val Asp Leu Pro Gly Gly Met
Thr Val Leu Val Ser Lys 210 215 220 gaa aaa gac aaa gac ggt aaa tac
agt cta gag gca aca gta gac aag 720 Glu Lys Asp Lys Asp Gly Lys Tyr
Ser Leu Glu Ala Thr Val Asp Lys 225 230 235 240 ctt gag ctt aaa gga
act tct gat aaa aac aac ggt tct gga aca ctt 768 Leu Glu Leu Lys Gly
Thr Ser Asp Lys Asn Asn Gly Ser Gly Thr Leu 245 250 255 gaa ggt gaa
aaa act gac aaa agt aaa gta aaa tta aca att gct gat 816 Glu Gly Glu
Lys Thr Asp Lys Ser Lys Val Lys Leu Thr Ile Ala Asp 260 265 270 gac
cta agt caa act aaa ttt gaa att ttc aaa gaa gat gcc aaa aca 864 Asp
Leu Ser Gln Thr Lys Phe Glu Ile Phe Lys Glu Asp Ala Lys Thr 275 280
285 tta gta tca aaa aaa gta acc ctt aaa gac aag tca tca aca gaa gaa
912 Leu Val Ser Lys Lys Val Thr Leu Lys Asp Lys Ser Ser Thr Glu Glu
290 295 300 aaa ttc aac gaa aag ggt gaa aca tct gaa aaa aca ata gta
aga gca 960 Lys Phe Asn Glu Lys Gly Glu Thr Ser Glu Lys Thr Ile Val
Arg Ala 305 310 315 320 aat gga acc aga ctt gaa tac aca gac ata aaa
agc gat gga tcc gga 1008 Asn Gly Thr Arg Leu Glu Tyr Thr Asp Ile
Lys Ser Asp Gly Ser Gly 325 330 335 aaa gct aaa gaa gtt tta aaa gac
ttt act ctt gaa gga act cta gct 1056 Lys Ala Lys Glu Val Leu Lys
Asp Phe Thr Leu Glu Gly Thr Leu Ala 340 345 350 gct gac ggc aaa aca
aca ttg aaa gtt aca gaa ggc act gtt gtt tta 1104 Ala Asp Gly Lys
Thr Thr Leu Lys Val Thr Glu Gly Thr Val Val Leu 355 360 365 agc aag
aac att tta aaa tcc gga gaa ata aca gtt gca ctt gat gac 1152 Ser
Lys Asn Ile Leu Lys Ser Gly Glu Ile Thr Val Ala Leu Asp Asp 370 375
380 tct gac act act cag gct act aaa aaa act gga aaa tgg gat tca aat
1200 Ser Asp Thr Thr Gln Ala Thr Lys Lys Thr Gly Lys Trp Asp Ser
Asn 385 390 395 400 act tcc act tta aca att agt gtg aat agc aaa aaa
act aaa aac att 1248 Thr Ser Thr Leu Thr Ile Ser Val Asn Ser Lys
Lys Thr Lys Asn Ile 405 410 415 gta ttt aca aaa gaa gac aca ata aca
gta caa aaa tac gac tca gca 1296 Val Phe Thr Lys Glu Asp Thr Ile
Thr Val Gln Lys Tyr Asp Ser Ala 420 425 430 ggc acc aat cta gaa ggc
aac gca gtc gaa att aaa aca ctt gat gaa 1344 Gly Thr Asn Leu Glu
Gly Asn Ala Val Glu Ile Lys Thr Leu Asp Glu 435 440 445 ctt aaa aac
gct tta aaa tag 1365 Leu Lys Asn Ala Leu Lys * 450 70 454 PRT
Artificial Sequence Chimeric protein 70 Met Ala Cys Asn Asn Ser Gly
Lys Asp Gly Asn Thr Ser Ala Asn Ser 1 5 10 15 Ala Asp Glu Ser Val
Lys Gly Pro Asn Leu Thr Glu Ile Ser Lys Lys 20 25 30 Ile Thr Asp
Ser Asn Ala Val Leu Leu Ala Val Lys Glu Val Glu Ala 35 40 45 Leu
Leu Ser Ser Ile Asp Glu Ile Ala Ala Lys Ala Ile Gly Lys Lys 50 55
60 Ile His Gln Asn Asn Gly Leu Asp Thr Glu Tyr Asn His Asn Gly Ser
65 70 75 80 Leu Leu Ala Gly Ala Tyr Ala Ile Ser Thr Leu Ile Lys Gln
Lys Leu 85 90 95 Asp Gly Leu Lys Asn Glu Gly Leu Lys Glu Lys Ile
Asp Ala Ala Lys 100 105 110 Lys Cys Ser Glu Thr Phe Thr Asn Lys Leu
Lys Glu Lys His Thr Asp 115
120 125 Leu Gly Lys Glu Gly Val Thr Asp Ala Asp Ala Lys Glu Ala Ile
Leu 130 135 140 Lys Thr Asn Gly Thr Lys Thr Lys Gly Ala Glu Glu Leu
Gly Lys Leu 145 150 155 160 Phe Glu Ser Val Glu Val Leu Ser Lys Ala
Ala Lys Glu Met Leu Ala 165 170 175 Asn Ser Val Lys Glu Leu Thr Ser
Pro Val Val Ala Glu Ser Pro Lys 180 185 190 Lys Pro Ser Met Ala Lys
Gln Asn Val Ser Ser Leu Asp Glu Lys Asn 195 200 205 Ser Val Ser Val
Asp Leu Pro Gly Gly Met Thr Val Leu Val Ser Lys 210 215 220 Glu Lys
Asp Lys Asp Gly Lys Tyr Ser Leu Glu Ala Thr Val Asp Lys 225 230 235
240 Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Thr Leu
245 250 255 Glu Gly Glu Lys Thr Asp Lys Ser Lys Val Lys Leu Thr Ile
Ala Asp 260 265 270 Asp Leu Ser Gln Thr Lys Phe Glu Ile Phe Lys Glu
Asp Ala Lys Thr 275 280 285 Leu Val Ser Lys Lys Val Thr Leu Lys Asp
Lys Ser Ser Thr Glu Glu 290 295 300 Lys Phe Asn Glu Lys Gly Glu Thr
Ser Glu Lys Thr Ile Val Arg Ala 305 310 315 320 Asn Gly Thr Arg Leu
Glu Tyr Thr Asp Ile Lys Ser Asp Gly Ser Gly 325 330 335 Lys Ala Lys
Glu Val Leu Lys Asp Phe Thr Leu Glu Gly Thr Leu Ala 340 345 350 Ala
Asp Gly Lys Thr Thr Leu Lys Val Thr Glu Gly Thr Val Val Leu 355 360
365 Ser Lys Asn Ile Leu Lys Ser Gly Glu Ile Thr Val Ala Leu Asp Asp
370 375 380 Ser Asp Thr Thr Gln Ala Thr Lys Lys Thr Gly Lys Trp Asp
Ser Asn 385 390 395 400 Thr Ser Thr Leu Thr Ile Ser Val Asn Ser Lys
Lys Thr Lys Asn Ile 405 410 415 Val Phe Thr Lys Glu Asp Thr Ile Thr
Val Gln Lys Tyr Asp Ser Ala 420 425 430 Gly Thr Asn Leu Glu Gly Asn
Ala Val Glu Ile Lys Thr Leu Asp Glu 435 440 445 Leu Lys Asn Ala Leu
Lys 450 71 1344 DNA Artificial Sequence Chimeric nucleic acid 71
atg gct tgt aat aat tca ggg aaa gat ggg aat aca tct gca aat tct 48
Met Ala Cys Asn Asn Ser Gly Lys Asp Gly Asn Thr Ser Ala Asn Ser 1 5
10 15 gct gat gag tct gtt aaa ggg cct aat ctt aca gaa ata agt aaa
aaa 96 Ala Asp Glu Ser Val Lys Gly Pro Asn Leu Thr Glu Ile Ser Lys
Lys 20 25 30 att acg gat tct aat gcg gtt tta ctt gct gtg aaa gag
gtt gaa gcg 144 Ile Thr Asp Ser Asn Ala Val Leu Leu Ala Val Lys Glu
Val Glu Ala 35 40 45 ttg ctg tca tct ata gat gag ctt gct aaa gct
att ggt aaa aaa ata 192 Leu Leu Ser Ser Ile Asp Glu Leu Ala Lys Ala
Ile Gly Lys Lys Ile 50 55 60 aaa aac gat ggt agt tta gat aat gaa
gca aat cgc aac gag tca ttg 240 Lys Asn Asp Gly Ser Leu Asp Asn Glu
Ala Asn Arg Asn Glu Ser Leu 65 70 75 80 tta gca gga gct tat aca ata
tca acc tta ata aca caa aaa tta agt 288 Leu Ala Gly Ala Tyr Thr Ile
Ser Thr Leu Ile Thr Gln Lys Leu Ser 85 90 95 aaa tta aac gga tca
gaa ggt tta aag gaa aag att gcc gca gct aag 336 Lys Leu Asn Gly Ser
Glu Gly Leu Lys Glu Lys Ile Ala Ala Ala Lys 100 105 110 aaa tgc tct
gaa gag ttt agt act aaa cta aaa gat aat cat gca cag 384 Lys Cys Ser
Glu Glu Phe Ser Thr Lys Leu Lys Asp Asn His Ala Gln 115 120 125 ctt
ggt ata cag ggc gtt act gat gaa aat gca aaa aaa gct att tta 432 Leu
Gly Ile Gln Gly Val Thr Asp Glu Asn Ala Lys Lys Ala Ile Leu 130 135
140 aaa gca aat gca gcg ggt aaa gat aag ggc gtt gaa gaa ctt gaa aag
480 Lys Ala Asn Ala Ala Gly Lys Asp Lys Gly Val Glu Glu Leu Glu Lys
145 150 155 160 ttg tcc gga tca tta gaa agc tta tca aaa gca gct aaa
gag atg ctt 528 Leu Ser Gly Ser Leu Glu Ser Leu Ser Lys Ala Ala Lys
Glu Met Leu 165 170 175 gct aat tca gtt aaa gag ctt aca agc cct gtt
gtc cat ggc aag caa 576 Ala Asn Ser Val Lys Glu Leu Thr Ser Pro Val
Val His Gly Lys Gln 180 185 190 aat gtt agc agc ctt gat gaa aaa aat
agc gtt tca gta gat tta cct 624 Asn Val Ser Ser Leu Asp Glu Lys Asn
Ser Val Ser Val Asp Leu Pro 195 200 205 ggt gga atg aca gtt ctt gta
agt aaa gaa aaa gac aaa gac ggt aaa 672 Gly Gly Met Thr Val Leu Val
Ser Lys Glu Lys Asp Lys Asp Gly Lys 210 215 220 tac agt cta gag gca
aca gta gac aag ctt gag ctt aaa gga act tct 720 Tyr Ser Leu Glu Ala
Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser 225 230 235 240 gat aaa
aac aac ggt tct gga aca ctt gaa ggt gaa aaa act gac aaa 768 Asp Lys
Asn Asn Gly Ser Gly Thr Leu Glu Gly Glu Lys Thr Asp Lys 245 250 255
agt aaa gta aaa tta aca att gct gat gac cta agt caa act aaa ttt 816
Ser Lys Val Lys Leu Thr Ile Ala Asp Asp Leu Ser Gln Thr Lys Phe 260
265 270 gaa att ttc aaa gaa gat gcc aaa aca tta gta tca aaa aaa gta
acc 864 Glu Ile Phe Lys Glu Asp Ala Lys Thr Leu Val Ser Lys Lys Val
Thr 275 280 285 ctt aaa gac aag tca tca aca gaa gaa aaa ttc aac gaa
aag ggt gaa 912 Leu Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn Glu
Lys Gly Glu 290 295 300 aca tct gaa aaa aca ata gta aga gca aat gga
acc aga ctt gaa tac 960 Thr Ser Glu Lys Thr Ile Val Arg Ala Asn Gly
Thr Arg Leu Glu Tyr 305 310 315 320 aca gac ata aaa agc gat gga tcc
gga aaa gct aaa gaa gtt tta aaa 1008 Thr Asp Ile Lys Ser Asp Gly
Ser Gly Lys Ala Lys Glu Val Leu Lys 325 330 335 gac ttt act ctt gaa
gga act cta gct gct gac ggc aaa aca aca ttg 1056 Asp Phe Thr Leu
Glu Gly Thr Leu Ala Ala Asp Gly Lys Thr Thr Leu 340 345 350 aaa gtt
aca gaa ggc act gtt gtt tta agc aag aac att tta aaa tcc 1104 Lys
Val Thr Glu Gly Thr Val Val Leu Ser Lys Asn Ile Leu Lys Ser 355 360
365 gga gaa ata aca gtt gca ctt gat gac tct gac act act cag gct act
1152 Gly Glu Ile Thr Val Ala Leu Asp Asp Ser Asp Thr Thr Gln Ala
Thr 370 375 380 aaa aaa act gga aaa tgg gat tca aat act tcc act tta
aca att agt 1200 Lys Lys Thr Gly Lys Trp Asp Ser Asn Thr Ser Thr
Leu Thr Ile Ser 385 390 395 400 gtg aat agc aaa aaa act aaa aac att
gta ttt aca aaa gaa gac aca 1248 Val Asn Ser Lys Lys Thr Lys Asn
Ile Val Phe Thr Lys Glu Asp Thr 405 410 415 ata aca gta caa aaa tac
gac tca gca ggc acc aat cta gaa ggc aac 1296 Ile Thr Val Gln Lys
Tyr Asp Ser Ala Gly Thr Asn Leu Glu Gly Asn 420 425 430 gca gtc gaa
att aaa aca ctt gat gaa ctt aaa aac gct tta aaa tag 1344 Ala Val
Glu Ile Lys Thr Leu Asp Glu Leu Lys Asn Ala Leu Lys * 435 440 445
72 447 PRT Artificial Sequence Chimeric protein 72 Met Ala Cys Asn
Asn Ser Gly Lys Asp Gly Asn Thr Ser Ala Asn Ser 1 5 10 15 Ala Asp
Glu Ser Val Lys Gly Pro Asn Leu Thr Glu Ile Ser Lys Lys 20 25 30
Ile Thr Asp Ser Asn Ala Val Leu Leu Ala Val Lys Glu Val Glu Ala 35
40 45 Leu Leu Ser Ser Ile Asp Glu Leu Ala Lys Ala Ile Gly Lys Lys
Ile 50 55 60 Lys Asn Asp Gly Ser Leu Asp Asn Glu Ala Asn Arg Asn
Glu Ser Leu 65 70 75 80 Leu Ala Gly Ala Tyr Thr Ile Ser Thr Leu Ile
Thr Gln Lys Leu Ser 85 90 95 Lys Leu Asn Gly Ser Glu Gly Leu Lys
Glu Lys Ile Ala Ala Ala Lys 100 105 110 Lys Cys Ser Glu Glu Phe Ser
Thr Lys Leu Lys Asp Asn His Ala Gln 115 120 125 Leu Gly Ile Gln Gly
Val Thr Asp Glu Asn Ala Lys Lys Ala Ile Leu 130 135 140 Lys Ala Asn
Ala Ala Gly Lys Asp Lys Gly Val Glu Glu Leu Glu Lys 145 150 155 160
Leu Ser Gly Ser Leu Glu Ser Leu Ser Lys Ala Ala Lys Glu Met Leu 165
170 175 Ala Asn Ser Val Lys Glu Leu Thr Ser Pro Val Val His Gly Lys
Gln 180 185 190 Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val Ser Val
Asp Leu Pro 195 200 205 Gly Gly Met Thr Val Leu Val Ser Lys Glu Lys
Asp Lys Asp Gly Lys 210 215 220 Tyr Ser Leu Glu Ala Thr Val Asp Lys
Leu Glu Leu Lys Gly Thr Ser 225 230 235 240 Asp Lys Asn Asn Gly Ser
Gly Thr Leu Glu Gly Glu Lys Thr Asp Lys 245 250 255 Ser Lys Val Lys
Leu Thr Ile Ala Asp Asp Leu Ser Gln Thr Lys Phe 260 265 270 Glu Ile
Phe Lys Glu Asp Ala Lys Thr Leu Val Ser Lys Lys Val Thr 275 280 285
Leu Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu 290
295 300 Thr Ser Glu Lys Thr Ile Val Arg Ala Asn Gly Thr Arg Leu Glu
Tyr 305 310 315 320 Thr Asp Ile Lys Ser Asp Gly Ser Gly Lys Ala Lys
Glu Val Leu Lys 325 330 335 Asp Phe Thr Leu Glu Gly Thr Leu Ala Ala
Asp Gly Lys Thr Thr Leu 340 345 350 Lys Val Thr Glu Gly Thr Val Val
Leu Ser Lys Asn Ile Leu Lys Ser 355 360 365 Gly Glu Ile Thr Val Ala
Leu Asp Asp Ser Asp Thr Thr Gln Ala Thr 370 375 380 Lys Lys Thr Gly
Lys Trp Asp Ser Asn Thr Ser Thr Leu Thr Ile Ser 385 390 395 400 Val
Asn Ser Lys Lys Thr Lys Asn Ile Val Phe Thr Lys Glu Asp Thr 405 410
415 Ile Thr Val Gln Lys Tyr Asp Ser Ala Gly Thr Asn Leu Glu Gly Asn
420 425 430 Ala Val Glu Ile Lys Thr Leu Asp Glu Leu Lys Asn Ala Leu
Lys 435 440 445 73 1305 DNA Artificial Sequence Chimeric nucleic
acid 73 atg gct tgt aat aat tca gga aaa gat ggg aat aca tct gca aat
tct 48 Met Ala Cys Asn Asn Ser Gly Lys Asp Gly Asn Thr Ser Ala Asn
Ser 1 5 10 15 gct gat gag tct gtt aaa ggg cct aat ctt aca gaa ata
agt aaa aaa 96 Ala Asp Glu Ser Val Lys Gly Pro Asn Leu Thr Glu Ile
Ser Lys Lys 20 25 30 att aca gaa tct aac gca gtt gtt ctg gct gtg
aaa gaa att gaa act 144 Ile Thr Glu Ser Asn Ala Val Val Leu Ala Val
Lys Glu Ile Glu Thr 35 40 45 ttg ctt gca tct ata gat gaa ctt gct
act aaa gct att ggt aaa aaa 192 Leu Leu Ala Ser Ile Asp Glu Leu Ala
Thr Lys Ala Ile Gly Lys Lys 50 55 60 ata caa caa aat ggt ggt tta
gct gtc gaa gcg ggg cat aat gga aca 240 Ile Gln Gln Asn Gly Gly Leu
Ala Val Glu Ala Gly His Asn Gly Thr 65 70 75 80 ttg tta gca ggt gct
tat aca ata tca aaa cta ata aca caa aaa tta 288 Leu Leu Ala Gly Ala
Tyr Thr Ile Ser Lys Leu Ile Thr Gln Lys Leu 85 90 95 gat gga ttg
aaa aat tca gaa aaa tta aag gaa aaa att gaa aat gct 336 Asp Gly Leu
Lys Asn Ser Glu Lys Leu Lys Glu Lys Ile Glu Asn Ala 100 105 110 aag
aaa tgt tct gaa gat ttt act aaa aaa cta gaa gga gaa cat gcg 384 Lys
Lys Cys Ser Glu Asp Phe Thr Lys Lys Leu Glu Gly Glu His Ala 115 120
125 caa ctt gga att gaa aat gtt act gat gag aat gca aaa aaa gct att
432 Gln Leu Gly Ile Glu Asn Val Thr Asp Glu Asn Ala Lys Lys Ala Ile
130 135 140 tta ata aca gat gca gct aaa gat aag ggc gct gca gag ctt
gaa aag 480 Leu Ile Thr Asp Ala Ala Lys Asp Lys Gly Ala Ala Glu Leu
Glu Lys 145 150 155 160 cta ttt aaa gca gta gaa aac ttg gca aaa gca
gct aaa gag atg ctt 528 Leu Phe Lys Ala Val Glu Asn Leu Ala Lys Ala
Ala Lys Glu Met Leu 165 170 175 gct aat tca gtt aaa gag ctt aca agt
cct att gtg cat ggc gtt tca 576 Ala Asn Ser Val Lys Glu Leu Thr Ser
Pro Ile Val His Gly Val Ser 180 185 190 gta gat ttg cct ggt gaa atg
aaa gtt ctt gta agc aaa gaa aaa aac 624 Val Asp Leu Pro Gly Glu Met
Lys Val Leu Val Ser Lys Glu Lys Asn 195 200 205 aaa gac ggc aag tac
gat cta att gca aca gta gac aag ctt gag ctt 672 Lys Asp Gly Lys Tyr
Asp Leu Ile Ala Thr Val Asp Lys Leu Glu Leu 210 215 220 aaa gga act
tct gat aaa aac aat gga tct gga gta ctt gaa ggc gta 720 Lys Gly Thr
Ser Asp Lys Asn Asn Gly Ser Gly Val Leu Glu Gly Val 225 230 235 240
aaa gct gac aaa agt aaa gta aaa tta aca att tct gac gat cta ggt 768
Lys Ala Asp Lys Ser Lys Val Lys Leu Thr Ile Ser Asp Asp Leu Gly 245
250 255 caa acc aca ctt gaa gtt ttc aaa gaa gat ggc aaa aca cta gta
tca 816 Gln Thr Thr Leu Glu Val Phe Lys Glu Asp Gly Lys Thr Leu Val
Ser 260 265 270 aaa aaa gta act tcc aaa gac aag tca tca aca gaa gaa
aaa ttc aat 864 Lys Lys Val Thr Ser Lys Asp Lys Ser Ser Thr Glu Glu
Lys Phe Asn 275 280 285 gaa aaa ggt gaa gta tct gaa aaa ata ata aca
aga gca gac gga acc 912 Glu Lys Gly Glu Val Ser Glu Lys Ile Ile Thr
Arg Ala Asp Gly Thr 290 295 300 aga ctt gaa tac aca gga att aaa agc
gat gga tct gga aaa gct aaa 960 Arg Leu Glu Tyr Thr Gly Ile Lys Ser
Asp Gly Ser Gly Lys Ala Lys 305 310 315 320 gag gtt tta aaa aaa ttt
act ctt gaa gga aaa gta gct aat gat aaa 1008 Glu Val Leu Lys Lys
Phe Thr Leu Glu Gly Lys Val Ala Asn Asp Lys 325 330 335 gta aca ttg
gaa gta aaa gaa gga acc gtt act tta agt aag aac att 1056 Val Thr
Leu Glu Val Lys Glu Gly Thr Val Thr Leu Ser Lys Asn Ile 340 345 350
tca aaa tct ggg gaa gtt tca gtt gaa ctt aat gac act gac agt agt
1104 Ser Lys Ser Gly Glu Val Ser Val Glu Leu Asn Asp Thr Asp Ser
Ser 355 360 365 gct gct act aaa aaa act gca gct tgg aat tca ggc act
tca act tta 1152 Ala Ala Thr Lys Lys Thr Ala Ala Trp Asn Ser Gly
Thr Ser Thr Leu 370 375 380 aca att act gta aac agt aaa aaa act aaa
gac ctt gtg ttt aca aaa 1200 Thr Ile Thr Val Asn Ser Lys Lys Thr
Lys Asp Leu Val Phe Thr Lys 385 390 395 400 gaa aac aca att aca gta
caa caa tac gac tca aat ggc acc aaa tta 1248 Glu Asn Thr Ile Thr
Val Gln Gln Tyr Asp Ser Asn Gly Thr Lys Leu 405 410 415 gag ggg tca
gca gtt gaa att aca aaa ctt gat gaa att aaa aac gct 1296 Glu Gly
Ser Ala Val Glu Ile Thr Lys Leu Asp Glu Ile Lys Asn Ala 420 425 430
tta aaa taa 1305 Leu Lys * 74 434 PRT Artificial Sequence Chimeric
protein 74 Met Ala Cys Asn Asn Ser Gly Lys Asp Gly Asn Thr Ser Ala
Asn Ser 1 5 10 15 Ala Asp Glu Ser Val Lys Gly Pro Asn Leu Thr Glu
Ile Ser Lys Lys 20 25 30 Ile Thr Glu Ser Asn Ala Val Val Leu Ala
Val Lys Glu Ile Glu Thr 35 40 45 Leu Leu Ala Ser Ile Asp Glu Leu
Ala Thr Lys Ala Ile Gly Lys Lys 50 55 60 Ile Gln Gln Asn Gly Gly
Leu Ala Val Glu Ala Gly His Asn Gly Thr 65 70 75 80 Leu Leu Ala Gly
Ala Tyr Thr Ile Ser Lys Leu Ile Thr Gln Lys Leu 85 90 95 Asp Gly
Leu Lys Asn Ser Glu Lys Leu Lys Glu Lys Ile Glu Asn Ala 100 105 110
Lys Lys Cys Ser Glu Asp Phe Thr Lys Lys Leu Glu Gly Glu His Ala 115
120 125 Gln Leu Gly Ile Glu Asn Val Thr Asp Glu Asn Ala Lys Lys Ala
Ile 130 135 140 Leu Ile Thr Asp Ala Ala Lys Asp Lys Gly Ala Ala Glu
Leu Glu Lys 145 150 155 160 Leu Phe Lys Ala Val Glu Asn Leu Ala Lys
Ala Ala Lys Glu Met Leu 165 170 175 Ala Asn Ser Val Lys Glu Leu Thr
Ser Pro Ile Val His Gly Val Ser 180 185 190 Val Asp Leu Pro Gly Glu
Met Lys Val Leu Val Ser Lys Glu Lys Asn 195 200 205 Lys Asp Gly Lys
Tyr Asp Leu Ile Ala Thr Val Asp Lys Leu Glu Leu
210 215 220 Lys Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Val Leu Glu
Gly Val 225 230 235 240 Lys Ala Asp Lys Ser Lys Val Lys Leu Thr Ile
Ser Asp Asp Leu Gly 245 250 255 Gln Thr Thr Leu Glu Val Phe Lys Glu
Asp Gly Lys Thr Leu Val Ser 260 265 270 Lys Lys Val Thr Ser Lys Asp
Lys Ser Ser Thr Glu Glu Lys Phe Asn 275 280 285 Glu Lys Gly Glu Val
Ser Glu Lys Ile Ile Thr Arg Ala Asp Gly Thr 290 295 300 Arg Leu Glu
Tyr Thr Gly Ile Lys Ser Asp Gly Ser Gly Lys Ala Lys 305 310 315 320
Glu Val Leu Lys Lys Phe Thr Leu Glu Gly Lys Val Ala Asn Asp Lys 325
330 335 Val Thr Leu Glu Val Lys Glu Gly Thr Val Thr Leu Ser Lys Asn
Ile 340 345 350 Ser Lys Ser Gly Glu Val Ser Val Glu Leu Asn Asp Thr
Asp Ser Ser 355 360 365 Ala Ala Thr Lys Lys Thr Ala Ala Trp Asn Ser
Gly Thr Ser Thr Leu 370 375 380 Thr Ile Thr Val Asn Ser Lys Lys Thr
Lys Asp Leu Val Phe Thr Lys 385 390 395 400 Glu Asn Thr Ile Thr Val
Gln Gln Tyr Asp Ser Asn Gly Thr Lys Leu 405 410 415 Glu Gly Ser Ala
Val Glu Ile Thr Lys Leu Asp Glu Ile Lys Asn Ala 420 425 430 Leu Lys
75 1332 DNA Artificial Sequence Chimeric nucleic acid 75 atg gct
tgt agt aat tca ggg aaa ggt ggg gat tct gca tct act aat 48 Met Ala
Cys Ser Asn Ser Gly Lys Gly Gly Asp Ser Ala Ser Thr Asn 1 5 10 15
cct gct gac gag tct gcg aaa ggg cct aat ctt aca gaa ata agc aaa 96
Pro Ala Asp Glu Ser Ala Lys Gly Pro Asn Leu Thr Glu Ile Ser Lys 20
25 30 aaa att aca gat tct aat gca ttt gta ctt gct gtt aaa gaa gtt
gag 144 Lys Ile Thr Asp Ser Asn Ala Phe Val Leu Ala Val Lys Glu Val
Glu 35 40 45 act ttg gtt tta tct ata gat gaa ctt gct aag aaa gct
att ggt caa 192 Thr Leu Val Leu Ser Ile Asp Glu Leu Ala Lys Lys Ala
Ile Gly Gln 50 55 60 aaa ata gac aat aat aat ggt tta gct gct tta
aat aat cag aat gga 240 Lys Ile Asp Asn Asn Asn Gly Leu Ala Ala Leu
Asn Asn Gln Asn Gly 65 70 75 80 tcg ttg tta gca gga gcc tat gca ata
tca acc cta ata aca gaa aaa 288 Ser Leu Leu Ala Gly Ala Tyr Ala Ile
Ser Thr Leu Ile Thr Glu Lys 85 90 95 ttg agt aaa ttg aaa aat tta
gaa gaa tta aag aca gaa att gca aag 336 Leu Ser Lys Leu Lys Asn Leu
Glu Glu Leu Lys Thr Glu Ile Ala Lys 100 105 110 gct aag aaa tgt tcc
gaa gaa ttt act aat aaa cta aaa agt ggt cat 384 Ala Lys Lys Cys Ser
Glu Glu Phe Thr Asn Lys Leu Lys Ser Gly His 115 120 125 gca gat ctt
ggc aaa cag gat gct acc gat gat cat gca aaa gca gct 432 Ala Asp Leu
Gly Lys Gln Asp Ala Thr Asp Asp His Ala Lys Ala Ala 130 135 140 att
tta aaa aca cat gca act acc gat aaa ggt gct aaa gaa ttt aaa 480 Ile
Leu Lys Thr His Ala Thr Thr Asp Lys Gly Ala Lys Glu Phe Lys 145 150
155 160 gat tta ttt gaa tca gta gaa ggt ttg tta aaa gca gct caa gta
gca 528 Asp Leu Phe Glu Ser Val Glu Gly Leu Leu Lys Ala Ala Gln Val
Ala 165 170 175 cta act aat tca gtt aaa gaa ctt aca agt cct gtt gta
gca gaa agt 576 Leu Thr Asn Ser Val Lys Glu Leu Thr Ser Pro Val Val
Ala Glu Ser 180 185 190 cca aaa aaa cct tcc atg gcc gtt tca gta gat
ttg cct ggt gaa atg 624 Pro Lys Lys Pro Ser Met Ala Val Ser Val Asp
Leu Pro Gly Glu Met 195 200 205 aaa gtt ctt gta agc aaa gaa aaa aac
aaa gac ggc aag tac gat cta 672 Lys Val Leu Val Ser Lys Glu Lys Asn
Lys Asp Gly Lys Tyr Asp Leu 210 215 220 att gca aca gta gac aag ctt
gag ctt aaa gga act tct gat aaa aac 720 Ile Ala Thr Val Asp Lys Leu
Glu Leu Lys Gly Thr Ser Asp Lys Asn 225 230 235 240 aat gga tct gga
gta ctt gaa ggc gta aaa gct gac aaa agt aaa gta 768 Asn Gly Ser Gly
Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val 245 250 255 aaa tta
aca att tct gac gat cta ggt caa acc aca ctt gaa gtt ttc 816 Lys Leu
Thr Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe 260 265 270
aaa gaa gat ggc aaa aca cta gta tca aaa aaa gta act tcc aaa gac 864
Lys Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp 275
280 285 aag tca tca aca gaa gaa aaa ttc aat gaa aaa ggt gaa gta tct
gaa 912 Lys Ser Ser Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser
Glu 290 295 300 aaa ata ata aca aga gca gac gga acc aga ctt gaa tac
aca gga att 960 Lys Ile Ile Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr
Thr Gly Ile 305 310 315 320 aaa agc gat gga tct gga aaa gct aaa gag
gtt tta aaa aaa ttt act 1008 Lys Ser Asp Gly Ser Gly Lys Ala Lys
Glu Val Leu Lys Lys Phe Thr 325 330 335 ctt gaa gga aaa gta gct aat
gat aaa gta aca ttg gaa gta aaa gaa 1056 Leu Glu Gly Lys Val Ala
Asn Asp Lys Val Thr Leu Glu Val Lys Glu 340 345 350 gga acc gtt act
tta agt aag aat att tca aaa tct ggg gaa gtt tca 1104 Gly Thr Val
Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Val Ser 355 360 365 gtt
gaa ctt aat gac act gac agt agt gct gct act aaa aaa act gca 1152
Val Glu Leu Asn Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala 370
375 380 gct tgg aat tca aaa act tcc act tta aca att agt gtg aat agc
caa 1200 Ala Trp Asn Ser Lys Thr Ser Thr Leu Thr Ile Ser Val Asn
Ser Gln 385 390 395 400 aaa acc aaa aac ctt gta ttc aca aaa gaa gac
aca ata aca gta caa 1248 Lys Thr Lys Asn Leu Val Phe Thr Lys Glu
Asp Thr Ile Thr Val Gln 405 410 415 aaa tac gac tca gca ggc acc aat
cta gaa ggc aaa gca gtc gaa att 1296 Lys Tyr Asp Ser Ala Gly Thr
Asn Leu Glu Gly Lys Ala Val Glu Ile 420 425 430 aca aca ctt aaa gaa
ctt aaa aac gct tta aaa taa 1332 Thr Thr Leu Lys Glu Leu Lys Asn
Ala Leu Lys * 435 440 76 443 PRT Artificial Sequence Chimeric
protein 76 Met Ala Cys Ser Asn Ser Gly Lys Gly Gly Asp Ser Ala Ser
Thr Asn 1 5 10 15 Pro Ala Asp Glu Ser Ala Lys Gly Pro Asn Leu Thr
Glu Ile Ser Lys 20 25 30 Lys Ile Thr Asp Ser Asn Ala Phe Val Leu
Ala Val Lys Glu Val Glu 35 40 45 Thr Leu Val Leu Ser Ile Asp Glu
Leu Ala Lys Lys Ala Ile Gly Gln 50 55 60 Lys Ile Asp Asn Asn Asn
Gly Leu Ala Ala Leu Asn Asn Gln Asn Gly 65 70 75 80 Ser Leu Leu Ala
Gly Ala Tyr Ala Ile Ser Thr Leu Ile Thr Glu Lys 85 90 95 Leu Ser
Lys Leu Lys Asn Leu Glu Glu Leu Lys Thr Glu Ile Ala Lys 100 105 110
Ala Lys Lys Cys Ser Glu Glu Phe Thr Asn Lys Leu Lys Ser Gly His 115
120 125 Ala Asp Leu Gly Lys Gln Asp Ala Thr Asp Asp His Ala Lys Ala
Ala 130 135 140 Ile Leu Lys Thr His Ala Thr Thr Asp Lys Gly Ala Lys
Glu Phe Lys 145 150 155 160 Asp Leu Phe Glu Ser Val Glu Gly Leu Leu
Lys Ala Ala Gln Val Ala 165 170 175 Leu Thr Asn Ser Val Lys Glu Leu
Thr Ser Pro Val Val Ala Glu Ser 180 185 190 Pro Lys Lys Pro Ser Met
Ala Val Ser Val Asp Leu Pro Gly Glu Met 195 200 205 Lys Val Leu Val
Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu 210 215 220 Ile Ala
Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn 225 230 235
240 Asn Gly Ser Gly Val Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val
245 250 255 Lys Leu Thr Ile Ser Asp Asp Leu Gly Gln Thr Thr Leu Glu
Val Phe 260 265 270 Lys Glu Asp Gly Lys Thr Leu Val Ser Lys Lys Val
Thr Ser Lys Asp 275 280 285 Lys Ser Ser Thr Glu Glu Lys Phe Asn Glu
Lys Gly Glu Val Ser Glu 290 295 300 Lys Ile Ile Thr Arg Ala Asp Gly
Thr Arg Leu Glu Tyr Thr Gly Ile 305 310 315 320 Lys Ser Asp Gly Ser
Gly Lys Ala Lys Glu Val Leu Lys Lys Phe Thr 325 330 335 Leu Glu Gly
Lys Val Ala Asn Asp Lys Val Thr Leu Glu Val Lys Glu 340 345 350 Gly
Thr Val Thr Leu Ser Lys Asn Ile Ser Lys Ser Gly Glu Val Ser 355 360
365 Val Glu Leu Asn Asp Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala
370 375 380 Ala Trp Asn Ser Lys Thr Ser Thr Leu Thr Ile Ser Val Asn
Ser Gln 385 390 395 400 Lys Thr Lys Asn Leu Val Phe Thr Lys Glu Asp
Thr Ile Thr Val Gln 405 410 415 Lys Tyr Asp Ser Ala Gly Thr Asn Leu
Glu Gly Lys Ala Val Glu Ile 420 425 430 Thr Thr Leu Lys Glu Leu Lys
Asn Ala Leu Lys 435 440 77 1317 DNA Artificial Sequence Chimeric
nucleic acid 77 atg gct tgt aat aat tca ggt ggg gat tct gca tct act
aat cct gat 48 Met Ala Cys Asn Asn Ser Gly Gly Asp Ser Ala Ser Thr
Asn Pro Asp 1 5 10 15 gag tct gca aaa gga cct aat ctt acc gta ata
agc aaa aaa att aca 96 Glu Ser Ala Lys Gly Pro Asn Leu Thr Val Ile
Ser Lys Lys Ile Thr 20 25 30 gat tct aat gca ttt tta ctg gct gtg
aaa gaa gtt gag gct ttg ctt 144 Asp Ser Asn Ala Phe Leu Leu Ala Val
Lys Glu Val Glu Ala Leu Leu 35 40 45 tca tct ata gat gaa ctt tct
aaa gct att ggt aaa aaa ata aaa aat 192 Ser Ser Ile Asp Glu Leu Ser
Lys Ala Ile Gly Lys Lys Ile Lys Asn 50 55 60 gat ggt act tta gat
aac gaa gca aat cga aac gaa tca ttg ata gca 240 Asp Gly Thr Leu Asp
Asn Glu Ala Asn Arg Asn Glu Ser Leu Ile Ala 65 70 75 80 gga gct tat
gaa ata tca aaa cta ata aca caa aaa tta agt gta ttg 288 Gly Ala Tyr
Glu Ile Ser Lys Leu Ile Thr Gln Lys Leu Ser Val Leu 85 90 95 aat
tca gaa gaa tta aag gaa aaa att aaa gag gct aag gat tgt tcc 336 Asn
Ser Glu Glu Leu Lys Glu Lys Ile Lys Glu Ala Lys Asp Cys Ser 100 105
110 gaa aaa ttt act act aag cta aaa gat agt cat gca gag ctt ggt ata
384 Glu Lys Phe Thr Thr Lys Leu Lys Asp Ser His Ala Glu Leu Gly Ile
115 120 125 caa agc gtt cag gat gat aat gca aaa aaa gct att tta aaa
aca cat 432 Gln Ser Val Gln Asp Asp Asn Ala Lys Lys Ala Ile Leu Lys
Thr His 130 135 140 gga act aaa gac aag ggt gct aaa gaa ctt gaa gag
tta ttt aaa tca 480 Gly Thr Lys Asp Lys Gly Ala Lys Glu Leu Glu Glu
Leu Phe Lys Ser 145 150 155 160 cta gaa agc ttg tca aaa gca gcg caa
gca gca tta act aat tca gtt 528 Leu Glu Ser Leu Ser Lys Ala Ala Gln
Ala Ala Leu Thr Asn Ser Val 165 170 175 aaa gag ctt aca aat cct gtt
gtg gca gaa agt cca aaa aaa cct tcc 576 Lys Glu Leu Thr Asn Pro Val
Val Ala Glu Ser Pro Lys Lys Pro Ser 180 185 190 atg gcc gtt tca gta
gat ttg cct ggt gaa atg aaa gtt ctt gta agc 624 Met Ala Val Ser Val
Asp Leu Pro Gly Glu Met Lys Val Leu Val Ser 195 200 205 aaa gaa aaa
aac aaa gac ggc aag tac gat cta att gca aca gta gac 672 Lys Glu Lys
Asn Lys Asp Gly Lys Tyr Asp Leu Ile Ala Thr Val Asp 210 215 220 aag
ctt gag ctt aaa gga act tct gat aaa aac aat gga tct gga gta 720 Lys
Leu Glu Leu Lys Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Val 225 230
235 240 ctt gaa ggc gta aaa gct gac aaa agt aaa gta aaa tta aca att
tct 768 Leu Glu Gly Val Lys Ala Asp Lys Ser Lys Val Lys Leu Thr Ile
Ser 245 250 255 gac gat cta ggt caa acc aca ctt gaa gtt ttc aaa gaa
gat ggc aaa 816 Asp Asp Leu Gly Gln Thr Thr Leu Glu Val Phe Lys Glu
Asp Gly Lys 260 265 270 aca cta gta tca aaa aaa gta act tcc aaa gac
aag tca tca aca gaa 864 Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp
Lys Ser Ser Thr Glu 275 280 285 gaa aaa ttc aat gaa aaa ggt gaa gta
tct gaa aaa ata ata aca aga 912 Glu Lys Phe Asn Glu Lys Gly Glu Val
Ser Glu Lys Ile Ile Thr Arg 290 295 300 gca gac gga acc aga ctt gaa
tac aca gga att aaa agc gat gga tct 960 Ala Asp Gly Thr Arg Leu Glu
Tyr Thr Gly Ile Lys Ser Asp Gly Ser 305 310 315 320 gga aaa gct aaa
gag gtt tta aaa aaa ttt act ctt gaa gga aaa gta 1008 Gly Lys Ala
Lys Glu Val Leu Lys Lys Phe Thr Leu Glu Gly Lys Val 325 330 335 gct
aat gat aaa gta aca ttg gaa gta aaa gaa gga acc gtt act tta 1056
Ala Asn Asp Lys Val Thr Leu Glu Val Lys Glu Gly Thr Val Thr Leu 340
345 350 agt aag aac att tca aaa tct ggg gaa gtt tca gtt gaa ctt aat
gac 1104 Ser Lys Asn Ile Ser Lys Ser Gly Glu Val Ser Val Glu Leu
Asn Asp 355 360 365 act gac agt agt gct gct act aaa aaa act gca gct
tgg aat tca aaa 1152 Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala
Ala Trp Asn Ser Lys 370 375 380 act tct act tta aca att agt gtt aac
agc aaa aaa act aca caa ctt 1200 Thr Ser Thr Leu Thr Ile Ser Val
Asn Ser Lys Lys Thr Thr Gln Leu 385 390 395 400 gtg ttt act aaa caa
gac aca ata act gta caa aaa tac gac tcc gca 1248 Val Phe Thr Lys
Gln Asp Thr Ile Thr Val Gln Lys Tyr Asp Ser Ala 405 410 415 ggt acc
aat tta gaa ggc aca gca gtc gaa att aaa aca ctt gat gaa 1296 Gly
Thr Asn Leu Glu Gly Thr Ala Val Glu Ile Lys Thr Leu Asp Glu 420 425
430 ctt aaa aac gct tta aaa taa 1317 Leu Lys Asn Ala Leu Lys * 435
78 438 PRT Artificial Sequence Chimeric protein 78 Met Ala Cys Asn
Asn Ser Gly Gly Asp Ser Ala Ser Thr Asn Pro Asp 1 5 10 15 Glu Ser
Ala Lys Gly Pro Asn Leu Thr Val Ile Ser Lys Lys Ile Thr 20 25 30
Asp Ser Asn Ala Phe Leu Leu Ala Val Lys Glu Val Glu Ala Leu Leu 35
40 45 Ser Ser Ile Asp Glu Leu Ser Lys Ala Ile Gly Lys Lys Ile Lys
Asn 50 55 60 Asp Gly Thr Leu Asp Asn Glu Ala Asn Arg Asn Glu Ser
Leu Ile Ala 65 70 75 80 Gly Ala Tyr Glu Ile Ser Lys Leu Ile Thr Gln
Lys Leu Ser Val Leu 85 90 95 Asn Ser Glu Glu Leu Lys Glu Lys Ile
Lys Glu Ala Lys Asp Cys Ser 100 105 110 Glu Lys Phe Thr Thr Lys Leu
Lys Asp Ser His Ala Glu Leu Gly Ile 115 120 125 Gln Ser Val Gln Asp
Asp Asn Ala Lys Lys Ala Ile Leu Lys Thr His 130 135 140 Gly Thr Lys
Asp Lys Gly Ala Lys Glu Leu Glu Glu Leu Phe Lys Ser 145 150 155 160
Leu Glu Ser Leu Ser Lys Ala Ala Gln Ala Ala Leu Thr Asn Ser Val 165
170 175 Lys Glu Leu Thr Asn Pro Val Val Ala Glu Ser Pro Lys Lys Pro
Ser 180 185 190 Met Ala Val Ser Val Asp Leu Pro Gly Glu Met Lys Val
Leu Val Ser 195 200 205 Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu
Ile Ala Thr Val Asp 210 215 220 Lys Leu Glu Leu Lys Gly Thr Ser Asp
Lys Asn Asn Gly Ser Gly Val 225 230 235 240 Leu Glu Gly Val Lys Ala
Asp Lys Ser Lys Val Lys Leu Thr Ile Ser 245 250 255 Asp Asp Leu Gly
Gln Thr Thr Leu Glu Val Phe Lys Glu Asp Gly Lys 260 265 270 Thr Leu
Val Ser Lys Lys Val Thr Ser Lys Asp Lys Ser Ser Thr Glu 275 280 285
Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys Ile Ile Thr Arg 290
295 300 Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys Ser Asp Gly
Ser 305 310 315 320 Gly Lys Ala Lys Glu Val Leu Lys Lys Phe Thr Leu
Glu Gly Lys Val 325 330 335 Ala
Asn Asp Lys Val Thr Leu Glu Val Lys Glu Gly Thr Val Thr Leu 340 345
350 Ser Lys Asn Ile Ser Lys Ser Gly Glu Val Ser Val Glu Leu Asn Asp
355 360 365 Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala Trp Asn
Ser Lys 370 375 380 Thr Ser Thr Leu Thr Ile Ser Val Asn Ser Lys Lys
Thr Thr Gln Leu 385 390 395 400 Val Phe Thr Lys Gln Asp Thr Ile Thr
Val Gln Lys Tyr Asp Ser Ala 405 410 415 Gly Thr Asn Leu Glu Gly Thr
Ala Val Glu Ile Lys Thr Leu Asp Glu 420 425 430 Leu Lys Asn Ala Leu
Lys 435 79 1029 DNA Artificial Sequence Chimeric nucleic acid 79
atg gct tgt aat aat tca ggg aaa gat ggg aat aca tct gca aat tct 48
Met Ala Cys Asn Asn Ser Gly Lys Asp Gly Asn Thr Ser Ala Asn Ser 1 5
10 15 gct gat gag tct gtt aaa ggg cct aat ctt aca gaa ata aat aaa
aaa 96 Ala Asp Glu Ser Val Lys Gly Pro Asn Leu Thr Glu Ile Asn Lys
Lys 20 25 30 att acg gat tct aat gcg gtt tta ctt gct gtg aaa gag
gtt gaa gcg 144 Ile Thr Asp Ser Asn Ala Val Leu Leu Ala Val Lys Glu
Val Glu Ala 35 40 45 ttg ctg tca tct ata gat gaa att gct gct aaa
gct att ggt aaa aaa 192 Leu Leu Ser Ser Ile Asp Glu Ile Ala Ala Lys
Ala Ile Gly Lys Lys 50 55 60 ata cac caa aat aat ggt ttg gat acc
gaa aat aat cac aat gga tca 240 Ile His Gln Asn Asn Gly Leu Asp Thr
Glu Asn Asn His Asn Gly Ser 65 70 75 80 ttg tta gcg gga gct tat gca
ata tca acc cta ata aaa caa aaa tta 288 Leu Leu Ala Gly Ala Tyr Ala
Ile Ser Thr Leu Ile Lys Gln Lys Leu 85 90 95 gat gga ttg aaa aat
gaa gga tta aag gaa aaa att gat gcg gct aag 336 Asp Gly Leu Lys Asn
Glu Gly Leu Lys Glu Lys Ile Asp Ala Ala Lys 100 105 110 aaa tgt tct
gaa aca ttt act aat aaa tta aaa gaa aaa cac aca gat 384 Lys Cys Ser
Glu Thr Phe Thr Asn Lys Leu Lys Glu Lys His Thr Asp 115 120 125 ctt
ggt aaa gaa ggt gtt act gat gct gat gca aaa gaa gcc att tta 432 Leu
Gly Lys Glu Gly Val Thr Asp Ala Asp Ala Lys Glu Ala Ile Leu 130 135
140 aaa gca aat ggt act aaa act aaa ggt gct gaa gaa ctt gga aaa tta
480 Lys Ala Asn Gly Thr Lys Thr Lys Gly Ala Glu Glu Leu Gly Lys Leu
145 150 155 160 ttt gaa tca gta gag gtc ttg tca aaa gca gct aaa gag
atg ctt gct 528 Phe Glu Ser Val Glu Val Leu Ser Lys Ala Ala Lys Glu
Met Leu Ala 165 170 175 aat tca gtt aaa gag ctt aca agc cct gtt gtg
gca gaa agt cca aaa 576 Asn Ser Val Lys Glu Leu Thr Ser Pro Val Val
Ala Glu Ser Pro Lys 180 185 190 aaa cct tcc atg gcc aag caa aat gtt
tct gaa aaa ata ata aca aga 624 Lys Pro Ser Met Ala Lys Gln Asn Val
Ser Glu Lys Ile Ile Thr Arg 195 200 205 gca gac gga acc aga ctt gaa
tac aca gga att aaa agc gat gga tct 672 Ala Asp Gly Thr Arg Leu Glu
Tyr Thr Gly Ile Lys Ser Asp Gly Ser 210 215 220 gga aaa gct aaa gag
gtt tta aaa ggc tat gtt ctt gaa gga act cta 720 Gly Lys Ala Lys Glu
Val Leu Lys Gly Tyr Val Leu Glu Gly Thr Leu 225 230 235 240 act gct
gaa aaa aca aca ttg gtg gtt aaa gaa gga act gtt act tta 768 Thr Ala
Glu Lys Thr Thr Leu Val Val Lys Glu Gly Thr Val Thr Leu 245 250 255
agc aaa aat att tca aaa tct ggg gaa gtt tca gtt gaa ctt aat gac 816
Ser Lys Asn Ile Ser Lys Ser Gly Glu Val Ser Val Glu Leu Asn Asp 260
265 270 act gac agt agt gct gct act aaa aaa act gca gct tgg aat tca
ggc 864 Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala Trp Asn Ser
Gly 275 280 285 act tca act tta aca att act gta aac agt aaa aaa act
aaa gac ctt 912 Thr Ser Thr Leu Thr Ile Thr Val Asn Ser Lys Lys Thr
Lys Asp Leu 290 295 300 gtg ttt aca aaa gaa aac aca att aca gta caa
caa tac gac tca aat 960 Val Phe Thr Lys Glu Asn Thr Ile Thr Val Gln
Gln Tyr Asp Ser Asn 305 310 315 320 ggc acc aaa tta gag ggg tca gca
gtt gaa att aca aaa ctt gat gaa 1008 Gly Thr Lys Leu Glu Gly Ser
Ala Val Glu Ile Thr Lys Leu Asp Glu 325 330 335 att aaa aac gct tta
aaa taa 1029 Ile Lys Asn Ala Leu Lys * 340 80 342 PRT Artificial
Sequence Chimeric protein 80 Met Ala Cys Asn Asn Ser Gly Lys Asp
Gly Asn Thr Ser Ala Asn Ser 1 5 10 15 Ala Asp Glu Ser Val Lys Gly
Pro Asn Leu Thr Glu Ile Asn Lys Lys 20 25 30 Ile Thr Asp Ser Asn
Ala Val Leu Leu Ala Val Lys Glu Val Glu Ala 35 40 45 Leu Leu Ser
Ser Ile Asp Glu Ile Ala Ala Lys Ala Ile Gly Lys Lys 50 55 60 Ile
His Gln Asn Asn Gly Leu Asp Thr Glu Asn Asn His Asn Gly Ser 65 70
75 80 Leu Leu Ala Gly Ala Tyr Ala Ile Ser Thr Leu Ile Lys Gln Lys
Leu 85 90 95 Asp Gly Leu Lys Asn Glu Gly Leu Lys Glu Lys Ile Asp
Ala Ala Lys 100 105 110 Lys Cys Ser Glu Thr Phe Thr Asn Lys Leu Lys
Glu Lys His Thr Asp 115 120 125 Leu Gly Lys Glu Gly Val Thr Asp Ala
Asp Ala Lys Glu Ala Ile Leu 130 135 140 Lys Ala Asn Gly Thr Lys Thr
Lys Gly Ala Glu Glu Leu Gly Lys Leu 145 150 155 160 Phe Glu Ser Val
Glu Val Leu Ser Lys Ala Ala Lys Glu Met Leu Ala 165 170 175 Asn Ser
Val Lys Glu Leu Thr Ser Pro Val Val Ala Glu Ser Pro Lys 180 185 190
Lys Pro Ser Met Ala Lys Gln Asn Val Ser Glu Lys Ile Ile Thr Arg 195
200 205 Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys Ser Asp Gly
Ser 210 215 220 Gly Lys Ala Lys Glu Val Leu Lys Gly Tyr Val Leu Glu
Gly Thr Leu 225 230 235 240 Thr Ala Glu Lys Thr Thr Leu Val Val Lys
Glu Gly Thr Val Thr Leu 245 250 255 Ser Lys Asn Ile Ser Lys Ser Gly
Glu Val Ser Val Glu Leu Asn Asp 260 265 270 Thr Asp Ser Ser Ala Ala
Thr Lys Lys Thr Ala Ala Trp Asn Ser Gly 275 280 285 Thr Ser Thr Leu
Thr Ile Thr Val Asn Ser Lys Lys Thr Lys Asp Leu 290 295 300 Val Phe
Thr Lys Glu Asn Thr Ile Thr Val Gln Gln Tyr Asp Ser Asn 305 310 315
320 Gly Thr Lys Leu Glu Gly Ser Ala Val Glu Ile Thr Lys Leu Asp Glu
325 330 335 Ile Lys Asn Ala Leu Lys 340 82 342 PRT Artificial
Sequence Chimeric protein 82 Met Ala Cys Asn Asn Ser Gly Lys Asp
Gly Asn Thr Ser Ala Asn Ser 1 5 10 15 Ala Asp Glu Ser Val Lys Gly
Pro Asn Leu Thr Glu Ile Asn Lys Lys 20 25 30 Ile Thr Asp Ser Asn
Ala Val Leu Leu Ala Val Lys Glu Val Glu Ala 35 40 45 Leu Leu Ser
Ser Ile Asp Glu Ile Ala Ala Lys Ala Ile Gly Lys Lys 50 55 60 Ile
His Gln Asn Asn Gly Leu Asp Thr Glu Asn Asn His Asn Gly Ser 65 70
75 80 Leu Leu Ala Gly Ala Tyr Ala Ile Ser Thr Leu Ile Lys Gln Lys
Leu 85 90 95 Asp Gly Leu Lys Asn Glu Gly Leu Lys Glu Lys Ile Asp
Ala Ala Lys 100 105 110 Lys Cys Ser Glu Thr Phe Thr Asn Lys Leu Lys
Glu Lys His Thr Asp 115 120 125 Leu Gly Lys Glu Gly Val Thr Asp Ala
Asp Ala Lys Glu Ala Ile Leu 130 135 140 Lys Ala Asn Gly Thr Lys Thr
Lys Gly Ala Glu Glu Leu Gly Lys Leu 145 150 155 160 Phe Glu Ser Val
Glu Val Leu Ser Lys Ala Ala Lys Glu Met Leu Ala 165 170 175 Asn Ser
Val Lys Glu Leu Thr Ser Pro Val Val Ala Glu Ser Pro Lys 180 185 190
Lys Pro Ser Met Ala Lys Gln Asn Val Ser Glu Lys Ile Ile Thr Arg 195
200 205 Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys Ser Asp Gly
Ser 210 215 220 Gly Lys Ala Lys Glu Val Leu Lys Gly Tyr Val Leu Glu
Gly Thr Leu 225 230 235 240 Thr Ala Glu Lys Thr Thr Leu Val Val Lys
Glu Gly Thr Val Thr Leu 245 250 255 Ser Lys Asn Ile Ser Lys Ser Gly
Glu Val Ser Val Glu Leu Asn Asp 260 265 270 Thr Asp Ser Ser Ala Ala
Thr Lys Lys Thr Ala Ala Trp Asn Ser Lys 275 280 285 Thr Ser Thr Leu
Thr Ile Ser Val Asn Ser Gln Lys Thr Lys Asn Leu 290 295 300 Val Phe
Thr Lys Glu Asp Thr Ile Thr Val Gln Lys Tyr Asp Ser Ala 305 310 315
320 Gly Thr Asn Leu Glu Gly Lys Ala Val Glu Ile Thr Thr Leu Lys Glu
325 330 335 Leu Lys Asn Ala Leu Lys 340 83 1029 DNA Artificial
Sequence Chimeric nucleic acid 83 atg gct tgt aat aat tca ggg aaa
gat ggg aat aca tct gca aat tct 48 Met Ala Cys Asn Asn Ser Gly Lys
Asp Gly Asn Thr Ser Ala Asn Ser 1 5 10 15 gct gat gag tct gtt aaa
ggg cct aat ctt aca gaa ata aat aaa aaa 96 Ala Asp Glu Ser Val Lys
Gly Pro Asn Leu Thr Glu Ile Asn Lys Lys 20 25 30 att acg gat tct
aat gcg gtt tta ctt gct gtg aaa gag gtt gaa gcg 144 Ile Thr Asp Ser
Asn Ala Val Leu Leu Ala Val Lys Glu Val Glu Ala 35 40 45 ttg ctg
tca tct ata gat gaa att gct gct aaa gct att ggt aaa aaa 192 Leu Leu
Ser Ser Ile Asp Glu Ile Ala Ala Lys Ala Ile Gly Lys Lys 50 55 60
ata cac caa aat aat ggt ttg gat acc gaa aat aat cac aat gga tca 240
Ile His Gln Asn Asn Gly Leu Asp Thr Glu Asn Asn His Asn Gly Ser 65
70 75 80 ttg tta gcg gga gct tat gca ata tca acc cta ata aaa caa
aaa tta 288 Leu Leu Ala Gly Ala Tyr Ala Ile Ser Thr Leu Ile Lys Gln
Lys Leu 85 90 95 gat gga ttg aaa aat gaa gga tta aag gaa aaa att
gat gcg gct aag 336 Asp Gly Leu Lys Asn Glu Gly Leu Lys Glu Lys Ile
Asp Ala Ala Lys 100 105 110 aaa tgt tct gaa aca ttt act aat aaa tta
aaa gaa aaa cac aca gat 384 Lys Cys Ser Glu Thr Phe Thr Asn Lys Leu
Lys Glu Lys His Thr Asp 115 120 125 ctt ggt aaa gaa ggt gtt act gat
gct gat gca aaa gaa gcc att tta 432 Leu Gly Lys Glu Gly Val Thr Asp
Ala Asp Ala Lys Glu Ala Ile Leu 130 135 140 aaa gca aat ggt act aaa
act aaa ggt gct gaa gaa ctt gga aaa tta 480 Lys Ala Asn Gly Thr Lys
Thr Lys Gly Ala Glu Glu Leu Gly Lys Leu 145 150 155 160 ttt gaa tca
gta gag gtc ttg tca aaa gca gct aaa gag atg ctt gct 528 Phe Glu Ser
Val Glu Val Leu Ser Lys Ala Ala Lys Glu Met Leu Ala 165 170 175 aat
tca gtt aaa gag ctt aca agc cct gtt gtg gca gaa agt cca aaa 576 Asn
Ser Val Lys Glu Leu Thr Ser Pro Val Val Ala Glu Ser Pro Lys 180 185
190 aaa cct tcc atg gcc aag caa aat gtt tct gaa aaa ata ata aca aga
624 Lys Pro Ser Met Ala Lys Gln Asn Val Ser Glu Lys Ile Ile Thr Arg
195 200 205 gca gac gga acc aga ctt gaa tac aca gga att aaa agc gat
gga tct 672 Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys Ser Asp
Gly Ser 210 215 220 gga aaa gct aaa gag gtt tta aaa ggc tat gtt ctt
gaa gga act cta 720 Gly Lys Ala Lys Glu Val Leu Lys Gly Tyr Val Leu
Glu Gly Thr Leu 225 230 235 240 act gct gaa aaa aca aca ttg gtg gtt
aaa gaa gga act gtt act tta 768 Thr Ala Glu Lys Thr Thr Leu Val Val
Lys Glu Gly Thr Val Thr Leu 245 250 255 agc aaa aat att tca aaa tct
ggg gaa gtt tca gtt gaa ctt aat gac 816 Ser Lys Asn Ile Ser Lys Ser
Gly Glu Val Ser Val Glu Leu Asn Asp 260 265 270 act gac agt agt gct
gct act aaa aaa act gca gct tgg aat tca aaa 864 Thr Asp Ser Ser Ala
Ala Thr Lys Lys Thr Ala Ala Trp Asn Ser Lys 275 280 285 act tct act
tta aca att agt gtt aac agc aaa aaa act aca caa ctt 912 Thr Ser Thr
Leu Thr Ile Ser Val Asn Ser Lys Lys Thr Thr Gln Leu 290 295 300 gtg
ttt act aaa caa gac aca ata act gta caa aaa tac gac tcc gca 960 Val
Phe Thr Lys Gln Asp Thr Ile Thr Val Gln Lys Tyr Asp Ser Ala 305 310
315 320 ggt acc aat tta gaa ggc aca gca gtc gaa att aaa aca ctt gat
gaa 1008 Gly Thr Asn Leu Glu Gly Thr Ala Val Glu Ile Lys Thr Leu
Asp Glu 325 330 335 ctt aaa aac gct tta aaa taa 1029 Leu Lys Asn
Ala Leu Lys * 340 84 342 PRT Artificial Sequence Chimeric protein
84 Met Ala Cys Asn Asn Ser Gly Lys Asp Gly Asn Thr Ser Ala Asn Ser
1 5 10 15 Ala Asp Glu Ser Val Lys Gly Pro Asn Leu Thr Glu Ile Asn
Lys Lys 20 25 30 Ile Thr Asp Ser Asn Ala Val Leu Leu Ala Val Lys
Glu Val Glu Ala 35 40 45 Leu Leu Ser Ser Ile Asp Glu Ile Ala Ala
Lys Ala Ile Gly Lys Lys 50 55 60 Ile His Gln Asn Asn Gly Leu Asp
Thr Glu Asn Asn His Asn Gly Ser 65 70 75 80 Leu Leu Ala Gly Ala Tyr
Ala Ile Ser Thr Leu Ile Lys Gln Lys Leu 85 90 95 Asp Gly Leu Lys
Asn Glu Gly Leu Lys Glu Lys Ile Asp Ala Ala Lys 100 105 110 Lys Cys
Ser Glu Thr Phe Thr Asn Lys Leu Lys Glu Lys His Thr Asp 115 120 125
Leu Gly Lys Glu Gly Val Thr Asp Ala Asp Ala Lys Glu Ala Ile Leu 130
135 140 Lys Ala Asn Gly Thr Lys Thr Lys Gly Ala Glu Glu Leu Gly Lys
Leu 145 150 155 160 Phe Glu Ser Val Glu Val Leu Ser Lys Ala Ala Lys
Glu Met Leu Ala 165 170 175 Asn Ser Val Lys Glu Leu Thr Ser Pro Val
Val Ala Glu Ser Pro Lys 180 185 190 Lys Pro Ser Met Ala Lys Gln Asn
Val Ser Glu Lys Ile Ile Thr Arg 195 200 205 Ala Asp Gly Thr Arg Leu
Glu Tyr Thr Gly Ile Lys Ser Asp Gly Ser 210 215 220 Gly Lys Ala Lys
Glu Val Leu Lys Gly Tyr Val Leu Glu Gly Thr Leu 225 230 235 240 Thr
Ala Glu Lys Thr Thr Leu Val Val Lys Glu Gly Thr Val Thr Leu 245 250
255 Ser Lys Asn Ile Ser Lys Ser Gly Glu Val Ser Val Glu Leu Asn Asp
260 265 270 Thr Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala Trp Asn
Ser Lys 275 280 285 Thr Ser Thr Leu Thr Ile Ser Val Asn Ser Lys Lys
Thr Thr Gln Leu 290 295 300 Val Phe Thr Lys Gln Asp Thr Ile Thr Val
Gln Lys Tyr Asp Ser Ala 305 310 315 320 Gly Thr Asn Leu Glu Gly Thr
Ala Val Glu Ile Lys Thr Leu Asp Glu 325 330 335 Leu Lys Asn Ala Leu
Lys 340 85 1035 DNA Artificial Sequence Chimeric nucleic acid 85
atg gct tgt aat aat tca ggg aaa gat ggg aat aca tct gca aat tct 48
Met Ala Cys Asn Asn Ser Gly Lys Asp Gly Asn Thr Ser Ala Asn Ser 1 5
10 15 gct gat gag tct gtt aaa ggg cct aat ctt aca gaa ata agt aaa
aaa 96 Ala Asp Glu Ser Val Lys Gly Pro Asn Leu Thr Glu Ile Ser Lys
Lys 20 25 30 att acg gat tct aat gcg gtt tta ctt gct gtg aaa gag
gtt gaa gcg 144 Ile Thr Asp Ser Asn Ala Val Leu Leu Ala Val Lys Glu
Val Glu Ala 35 40 45 ttg ctg tca tct ata gat gaa att gct gct aaa
gct att ggt aaa aaa 192 Leu Leu Ser Ser Ile Asp Glu Ile Ala Ala Lys
Ala Ile Gly Lys Lys 50 55 60 ata cac caa aat aat ggt ttg gat acc
gaa tat aat cac aat gga tca 240 Ile His Gln Asn Asn Gly Leu Asp Thr
Glu Tyr Asn His Asn Gly Ser 65 70 75 80 ttg tta gcg gga gct tat gca
ata tca acc cta ata aaa caa aaa tta 288 Leu Leu Ala Gly Ala Tyr Ala
Ile Ser Thr Leu Ile Lys Gln Lys Leu 85 90 95 gat gga ttg aaa aat
gaa gga tta aag gaa aaa att gat gcg gct aag 336 Asp Gly Leu Lys Asn
Glu Gly
Leu Lys Glu Lys Ile Asp Ala Ala Lys 100 105 110 aaa tgt tct gaa aca
ttt act aat aaa tta aaa gaa aaa cac aca gat 384 Lys Cys Ser Glu Thr
Phe Thr Asn Lys Leu Lys Glu Lys His Thr Asp 115 120 125 ctt ggt aaa
gaa ggt gtt act gat gct gat gca aaa gaa gcc att tta 432 Leu Gly Lys
Glu Gly Val Thr Asp Ala Asp Ala Lys Glu Ala Ile Leu 130 135 140 aaa
aca aat ggt act aaa act aaa ggt gct gaa gaa ctt gga aaa tta 480 Lys
Thr Asn Gly Thr Lys Thr Lys Gly Ala Glu Glu Leu Gly Lys Leu 145 150
155 160 ttt gaa tca gta gag gtc ttg tca aaa gca gct aaa gag atg ctt
gct 528 Phe Glu Ser Val Glu Val Leu Ser Lys Ala Ala Lys Glu Met Leu
Ala 165 170 175 aat tca gtt aaa gag ctt aca agc cct gtt gtg gca gaa
agt cca aaa 576 Asn Ser Val Lys Glu Leu Thr Ser Pro Val Val Ala Glu
Ser Pro Lys 180 185 190 aaa cct tcc atg gcc aag caa aat gtt aca tct
gaa aaa aca ata gta 624 Lys Pro Ser Met Ala Lys Gln Asn Val Thr Ser
Glu Lys Thr Ile Val 195 200 205 aga gca aat gga acc aga ctt gaa tac
aca gac ata aaa agc gat gga 672 Arg Ala Asn Gly Thr Arg Leu Glu Tyr
Thr Asp Ile Lys Ser Asp Gly 210 215 220 tcc gga aaa gct aaa gaa gtt
tta aaa gac ttt act ctt gaa gga act 720 Ser Gly Lys Ala Lys Glu Val
Leu Lys Asp Phe Thr Leu Glu Gly Thr 225 230 235 240 cta gct gct gac
ggc aaa aca aca ttg aaa gtt aca gaa ggc act gtt 768 Leu Ala Ala Asp
Gly Lys Thr Thr Leu Lys Val Thr Glu Gly Thr Val 245 250 255 gtt tta
agc aag aac att tta aaa tcc gga gaa ata aca gtt gca ctt 816 Val Leu
Ser Lys Asn Ile Leu Lys Ser Gly Glu Ile Thr Val Ala Leu 260 265 270
gat gac tct gac act act cag gct act aaa aaa act gga aaa tgg gat 864
Asp Asp Ser Asp Thr Thr Gln Ala Thr Lys Lys Thr Gly Lys Trp Asp 275
280 285 tca aat act tcc act tta aca att agt gtg aat agc aaa aaa act
aaa 912 Ser Asn Thr Ser Thr Leu Thr Ile Ser Val Asn Ser Lys Lys Thr
Lys 290 295 300 aac att gta ttt aca aaa gaa gac aca ata aca gta caa
aaa tac gac 960 Asn Ile Val Phe Thr Lys Glu Asp Thr Ile Thr Val Gln
Lys Tyr Asp 305 310 315 320 tca gca ggc acc aat cta gaa ggc aac gca
gtc gaa att aaa aca ctt 1008 Ser Ala Gly Thr Asn Leu Glu Gly Asn
Ala Val Glu Ile Lys Thr Leu 325 330 335 gat gaa ctt aaa aac gct tta
aaa tag 1035 Asp Glu Leu Lys Asn Ala Leu Lys * 340 86 344 PRT
Artificial Sequence Chimeric protein 86 Met Ala Cys Asn Asn Ser Gly
Lys Asp Gly Asn Thr Ser Ala Asn Ser 1 5 10 15 Ala Asp Glu Ser Val
Lys Gly Pro Asn Leu Thr Glu Ile Ser Lys Lys 20 25 30 Ile Thr Asp
Ser Asn Ala Val Leu Leu Ala Val Lys Glu Val Glu Ala 35 40 45 Leu
Leu Ser Ser Ile Asp Glu Ile Ala Ala Lys Ala Ile Gly Lys Lys 50 55
60 Ile His Gln Asn Asn Gly Leu Asp Thr Glu Tyr Asn His Asn Gly Ser
65 70 75 80 Leu Leu Ala Gly Ala Tyr Ala Ile Ser Thr Leu Ile Lys Gln
Lys Leu 85 90 95 Asp Gly Leu Lys Asn Glu Gly Leu Lys Glu Lys Ile
Asp Ala Ala Lys 100 105 110 Lys Cys Ser Glu Thr Phe Thr Asn Lys Leu
Lys Glu Lys His Thr Asp 115 120 125 Leu Gly Lys Glu Gly Val Thr Asp
Ala Asp Ala Lys Glu Ala Ile Leu 130 135 140 Lys Thr Asn Gly Thr Lys
Thr Lys Gly Ala Glu Glu Leu Gly Lys Leu 145 150 155 160 Phe Glu Ser
Val Glu Val Leu Ser Lys Ala Ala Lys Glu Met Leu Ala 165 170 175 Asn
Ser Val Lys Glu Leu Thr Ser Pro Val Val Ala Glu Ser Pro Lys 180 185
190 Lys Pro Ser Met Ala Lys Gln Asn Val Thr Ser Glu Lys Thr Ile Val
195 200 205 Arg Ala Asn Gly Thr Arg Leu Glu Tyr Thr Asp Ile Lys Ser
Asp Gly 210 215 220 Ser Gly Lys Ala Lys Glu Val Leu Lys Asp Phe Thr
Leu Glu Gly Thr 225 230 235 240 Leu Ala Ala Asp Gly Lys Thr Thr Leu
Lys Val Thr Glu Gly Thr Val 245 250 255 Val Leu Ser Lys Asn Ile Leu
Lys Ser Gly Glu Ile Thr Val Ala Leu 260 265 270 Asp Asp Ser Asp Thr
Thr Gln Ala Thr Lys Lys Thr Gly Lys Trp Asp 275 280 285 Ser Asn Thr
Ser Thr Leu Thr Ile Ser Val Asn Ser Lys Lys Thr Lys 290 295 300 Asn
Ile Val Phe Thr Lys Glu Asp Thr Ile Thr Val Gln Lys Tyr Asp 305 310
315 320 Ser Ala Gly Thr Asn Leu Glu Gly Asn Ala Val Glu Ile Lys Thr
Leu 325 330 335 Asp Glu Leu Lys Asn Ala Leu Lys 340 87 1323 DNA
Artificial Sequence Chimeric nucleic acid 87 atg gct tgt aat aat
tca ggg aaa gat ggg aat aca tct gca aat tct 48 Met Ala Cys Asn Asn
Ser Gly Lys Asp Gly Asn Thr Ser Ala Asn Ser 1 5 10 15 gct gat gag
tct gtt aaa ggg cct aat ctt aca gaa ata aat aaa aaa 96 Ala Asp Glu
Ser Val Lys Gly Pro Asn Leu Thr Glu Ile Asn Lys Lys 20 25 30 att
acg gat tct aat gcg gtt tta ctt gct gtg aaa gag gtt gaa gcg 144 Ile
Thr Asp Ser Asn Ala Val Leu Leu Ala Val Lys Glu Val Glu Ala 35 40
45 ttg ctg tca tct ata gat gaa att gct gct aaa gct att ggt aaa aaa
192 Leu Leu Ser Ser Ile Asp Glu Ile Ala Ala Lys Ala Ile Gly Lys Lys
50 55 60 ata cac caa aat aat ggt ttg gat acc gaa aat aat cac aat
gga tca 240 Ile His Gln Asn Asn Gly Leu Asp Thr Glu Asn Asn His Asn
Gly Ser 65 70 75 80 ttg tta gcg gga gct tat gca ata tca acc cta ata
aaa caa aaa tta 288 Leu Leu Ala Gly Ala Tyr Ala Ile Ser Thr Leu Ile
Lys Gln Lys Leu 85 90 95 gat gga ttg aaa aat gaa gga tta aag gaa
aaa att gat gcg gct aag 336 Asp Gly Leu Lys Asn Glu Gly Leu Lys Glu
Lys Ile Asp Ala Ala Lys 100 105 110 aaa tgt tct gaa aca ttt act aat
aaa tta aaa gaa aaa cac aca gat 384 Lys Cys Ser Glu Thr Phe Thr Asn
Lys Leu Lys Glu Lys His Thr Asp 115 120 125 ctt ggt aaa gaa ggt gtt
act gat gct gat gca aaa gaa gcc att tta 432 Leu Gly Lys Glu Gly Val
Thr Asp Ala Asp Ala Lys Glu Ala Ile Leu 130 135 140 aaa gca aat ggt
act aaa act aaa ggt gct gaa gaa ctt gga aaa tta 480 Lys Ala Asn Gly
Thr Lys Thr Lys Gly Ala Glu Glu Leu Gly Lys Leu 145 150 155 160 ttt
gaa tca gta gag gtc ttg tca aaa gca gct aaa gag atg ctt gct 528 Phe
Glu Ser Val Glu Val Leu Ser Lys Ala Ala Lys Glu Met Leu Ala 165 170
175 aat tca gtt aaa gag ctt aca agc cct gtt gtg gca gaa agt cca aaa
576 Asn Ser Val Lys Glu Leu Thr Ser Pro Val Val Ala Glu Ser Pro Lys
180 185 190 aaa cct tcc atg gcc gtt tca gta gat ttg cct ggt gaa atg
aaa gtt 624 Lys Pro Ser Met Ala Val Ser Val Asp Leu Pro Gly Glu Met
Lys Val 195 200 205 ctt gta agc aaa gaa aaa aac aaa gac ggc aag tac
gat cta att gca 672 Leu Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr
Asp Leu Ile Ala 210 215 220 aca gta gac aag ctt gag ctt aaa gga act
tct gat aaa aac aat gga 720 Thr Val Asp Lys Leu Glu Leu Lys Gly Thr
Ser Asp Lys Asn Asn Gly 225 230 235 240 tct gga gta ctt gaa ggc gta
aaa gct gac aaa agt aaa gta aaa tta 768 Ser Gly Val Leu Glu Gly Val
Lys Ala Asp Lys Ser Lys Val Lys Leu 245 250 255 aca att tct gac gat
cta ggt caa acc aca ctt gaa gtt ttc aaa gaa 816 Thr Ile Ser Asp Asp
Leu Gly Gln Thr Thr Leu Glu Val Phe Lys Glu 260 265 270 gat ggc aaa
aca cta gta tca aaa aaa gta act tcc aaa gac aag tca 864 Asp Gly Lys
Thr Leu Val Ser Lys Lys Val Thr Ser Lys Asp Lys Ser 275 280 285 tca
aca gaa gaa aaa ttc aat gaa aaa ggt gaa gta tct gaa aaa ata 912 Ser
Thr Glu Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys Ile 290 295
300 ata aca aga gca gac gga acc aga ctt gaa tac aca gga att aaa agc
960 Ile Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys Ser
305 310 315 320 gat gga tct gga aaa gct aaa gag gtt tta aaa ggc ttt
act ctt gaa 1008 Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly
Phe Thr Leu Glu 325 330 335 gga aaa gta gct aat gat aaa gta aca ttg
gaa gta aaa gaa gga acc 1056 Gly Lys Val Ala Asn Asp Lys Val Thr
Leu Glu Val Lys Glu Gly Thr 340 345 350 gtt act tta agt aag att tca
aaa tct ggg gaa gtt tca gtt gaa ctt 1104 Val Thr Leu Ser Lys Ile
Ser Lys Ser Gly Glu Val Ser Val Glu Leu 355 360 365 aat gac act gac
agt agt gct gct act aaa aaa act gca gct tgg aat 1152 Asn Asp Thr
Asp Ser Ser Ala Ala Thr Lys Lys Thr Ala Ala Trp Asn 370 375 380 tca
aaa act tct act tta aca att agt gtt aac agc aaa aaa act aca 1200
Ser Lys Thr Ser Thr Leu Thr Ile Ser Val Asn Ser Lys Lys Thr Thr 385
390 395 400 caa ctt gtg ttt act aaa caa gac aca ata act gta caa aaa
tac gac 1248 Gln Leu Val Phe Thr Lys Gln Asp Thr Ile Thr Val Gln
Lys Tyr Asp 405 410 415 tcc gca ggt acc aat tta gaa ggc aca gca gtc
gaa att aaa aca ctt 1296 Ser Ala Gly Thr Asn Leu Glu Gly Thr Ala
Val Glu Ile Lys Thr Leu 420 425 430 gat gaa ctt aaa aac gct tta aaa
taa 1323 Asp Glu Leu Lys Asn Ala Leu Lys * 435 440 88 440 PRT
Artificial Sequence Chimeric protein 88 Met Ala Cys Asn Asn Ser Gly
Lys Asp Gly Asn Thr Ser Ala Asn Ser 1 5 10 15 Ala Asp Glu Ser Val
Lys Gly Pro Asn Leu Thr Glu Ile Asn Lys Lys 20 25 30 Ile Thr Asp
Ser Asn Ala Val Leu Leu Ala Val Lys Glu Val Glu Ala 35 40 45 Leu
Leu Ser Ser Ile Asp Glu Ile Ala Ala Lys Ala Ile Gly Lys Lys 50 55
60 Ile His Gln Asn Asn Gly Leu Asp Thr Glu Asn Asn His Asn Gly Ser
65 70 75 80 Leu Leu Ala Gly Ala Tyr Ala Ile Ser Thr Leu Ile Lys Gln
Lys Leu 85 90 95 Asp Gly Leu Lys Asn Glu Gly Leu Lys Glu Lys Ile
Asp Ala Ala Lys 100 105 110 Lys Cys Ser Glu Thr Phe Thr Asn Lys Leu
Lys Glu Lys His Thr Asp 115 120 125 Leu Gly Lys Glu Gly Val Thr Asp
Ala Asp Ala Lys Glu Ala Ile Leu 130 135 140 Lys Ala Asn Gly Thr Lys
Thr Lys Gly Ala Glu Glu Leu Gly Lys Leu 145 150 155 160 Phe Glu Ser
Val Glu Val Leu Ser Lys Ala Ala Lys Glu Met Leu Ala 165 170 175 Asn
Ser Val Lys Glu Leu Thr Ser Pro Val Val Ala Glu Ser Pro Lys 180 185
190 Lys Pro Ser Met Ala Val Ser Val Asp Leu Pro Gly Glu Met Lys Val
195 200 205 Leu Val Ser Lys Glu Lys Asn Lys Asp Gly Lys Tyr Asp Leu
Ile Ala 210 215 220 Thr Val Asp Lys Leu Glu Leu Lys Gly Thr Ser Asp
Lys Asn Asn Gly 225 230 235 240 Ser Gly Val Leu Glu Gly Val Lys Ala
Asp Lys Ser Lys Val Lys Leu 245 250 255 Thr Ile Ser Asp Asp Leu Gly
Gln Thr Thr Leu Glu Val Phe Lys Glu 260 265 270 Asp Gly Lys Thr Leu
Val Ser Lys Lys Val Thr Ser Lys Asp Lys Ser 275 280 285 Ser Thr Glu
Glu Lys Phe Asn Glu Lys Gly Glu Val Ser Glu Lys Ile 290 295 300 Ile
Thr Arg Ala Asp Gly Thr Arg Leu Glu Tyr Thr Gly Ile Lys Ser 305 310
315 320 Asp Gly Ser Gly Lys Ala Lys Glu Val Leu Lys Gly Phe Thr Leu
Glu 325 330 335 Gly Lys Val Ala Asn Asp Lys Val Thr Leu Glu Val Lys
Glu Gly Thr 340 345 350 Val Thr Leu Ser Lys Ile Ser Lys Ser Gly Glu
Val Ser Val Glu Leu 355 360 365 Asn Asp Thr Asp Ser Ser Ala Ala Thr
Lys Lys Thr Ala Ala Trp Asn 370 375 380 Ser Lys Thr Ser Thr Leu Thr
Ile Ser Val Asn Ser Lys Lys Thr Thr 385 390 395 400 Gln Leu Val Phe
Thr Lys Gln Asp Thr Ile Thr Val Gln Lys Tyr Asp 405 410 415 Ser Ala
Gly Thr Asn Leu Glu Gly Thr Ala Val Glu Ile Lys Thr Leu 420 425 430
Asp Glu Leu Lys Asn Ala Leu Lys 435 440 89 1302 DNA Artificial
Sequence Chimeric nucleic acid 89 atg gct tgt aat aat tca ggg aaa
gat ggg aat aca tct gca aat tct 48 Met Ala Cys Asn Asn Ser Gly Lys
Asp Gly Asn Thr Ser Ala Asn Ser 1 5 10 15 gct gat gag tct gtt aaa
ggg cct aat ctt aca gaa ata agt aaa aaa 96 Ala Asp Glu Ser Val Lys
Gly Pro Asn Leu Thr Glu Ile Ser Lys Lys 20 25 30 att acg gat tct
aat gcg gtt tta ctt gct gtg aaa gag gtt gaa gcg 144 Ile Thr Asp Ser
Asn Ala Val Leu Leu Ala Val Lys Glu Val Glu Ala 35 40 45 ttg ctg
tca tct ata gat gag ctt gct aaa gct att ggt aaa aaa ata 192 Leu Leu
Ser Ser Ile Asp Glu Leu Ala Lys Ala Ile Gly Lys Lys Ile 50 55 60
aaa aac gat ggt agt tta gat aat gaa gca aat cgc aac gag tca ttg 240
Lys Asn Asp Gly Ser Leu Asp Asn Glu Ala Asn Arg Asn Glu Ser Leu 65
70 75 80 tta gca gga gct tat aca ata tca acc tta ata aca caa aaa
tta agt 288 Leu Ala Gly Ala Tyr Thr Ile Ser Thr Leu Ile Thr Gln Lys
Leu Ser 85 90 95 aaa tta aac gga tca gaa ggt tta aag gaa aag att
gcc gca gct aag 336 Lys Leu Asn Gly Ser Glu Gly Leu Lys Glu Lys Ile
Ala Ala Ala Lys 100 105 110 aaa tgc tct gaa gag ttt agt act aaa cta
aaa gat aat cat gca cag 384 Lys Cys Ser Glu Glu Phe Ser Thr Lys Leu
Lys Asp Asn His Ala Gln 115 120 125 ctt ggt ata cag ggc gtt act gat
gaa aat gca aaa aaa gct att tta 432 Leu Gly Ile Gln Gly Val Thr Asp
Glu Asn Ala Lys Lys Ala Ile Leu 130 135 140 aaa gca aat gca gcg ggt
aaa gat aag ggc gtt gaa gaa ctt gaa aag 480 Lys Ala Asn Ala Ala Gly
Lys Asp Lys Gly Val Glu Glu Leu Glu Lys 145 150 155 160 ttg tcc gga
tca tta gaa agc tta tca aaa gca gct aaa gag atg ctt 528 Leu Ser Gly
Ser Leu Glu Ser Leu Ser Lys Ala Ala Lys Glu Met Leu 165 170 175 gct
aat tca gtt aaa gag ctt aca agc cct gtt gtc cat ggc gtt tca 576 Ala
Asn Ser Val Lys Glu Leu Thr Ser Pro Val Val His Gly Val Ser 180 185
190 gta gat ttg cct ggt gaa atg aaa gtt ctt gta agc aaa gaa aaa aac
624 Val Asp Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys Asn
195 200 205 aaa gac ggc aag tac gat cta att gca aca gta gac aag ctt
gag ctt 672 Lys Asp Gly Lys Tyr Asp Leu Ile Ala Thr Val Asp Lys Leu
Glu Leu 210 215 220 aaa gga act tct gat aaa aac aat gga tct gga gta
ctt gaa ggc gta 720 Lys Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Val
Leu Glu Gly Val 225 230 235 240 aaa gct gac aaa agt aaa gta aaa tta
aca att tct gac gat cta ggt 768 Lys Ala Asp Lys Ser Lys Val Lys Leu
Thr Ile Ser Asp Asp Leu Gly 245 250 255 caa acc aca ctt gaa gtt ttc
aaa gaa gat ggc aaa aca cta gta tca 816 Gln Thr Thr Leu Glu Val Phe
Lys Glu Asp Gly Lys Thr Leu Val Ser 260 265 270 aaa aaa gta act tcc
aaa gac aag tca tca aca gaa gaa aaa ttc aat 864 Lys Lys Val Thr Ser
Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn 275 280 285 gaa aaa ggt
gaa gta tct gaa aaa ata ata aca aga gca gac gga acc 912 Glu Lys Gly
Glu Val Ser Glu Lys Ile Ile Thr Arg Ala Asp Gly Thr 290 295 300 aga
ctt gaa tac aca gga att aaa agc gat gga tct gga aaa gct aaa 960 Arg
Leu Glu Tyr Thr Gly Ile Lys Ser Asp Gly Ser Gly Lys Ala Lys 305 310
315 320 gag gtt tta aaa ggc ttt act ctt gaa gga aaa gta gct aat gat
aaa 1008 Glu Val Leu Lys Gly Phe Thr Leu Glu Gly Lys Val Ala Asn
Asp Lys
325 330 335 gta aca ttg gaa gta aaa gaa gga acc gtt act tta agt aag
att tca 1056 Val Thr Leu Glu Val Lys Glu Gly Thr Val Thr Leu Ser
Lys Ile Ser 340 345 350 aaa tct ggg gaa gtt tca gtt gaa ctt aat gac
act gac agt agt gct 1104 Lys Ser Gly Glu Val Ser Val Glu Leu Asn
Asp Thr Asp Ser Ser Ala 355 360 365 gct act aaa aaa act gca gct tgg
aat tca aaa act tct act tta aca 1152 Ala Thr Lys Lys Thr Ala Ala
Trp Asn Ser Lys Thr Ser Thr Leu Thr 370 375 380 att agt gtt aac agc
aaa aaa act aca caa ctt gtg ttt act aaa caa 1200 Ile Ser Val Asn
Ser Lys Lys Thr Thr Gln Leu Val Phe Thr Lys Gln 385 390 395 400 gac
aca ata act gta caa aaa tac gac tcc gca ggt acc aat tta gaa 1248
Asp Thr Ile Thr Val Gln Lys Tyr Asp Ser Ala Gly Thr Asn Leu Glu 405
410 415 ggc aca gca gtc gaa att aaa aca ctt gat gaa ctt aaa aac gct
tta 1296 Gly Thr Ala Val Glu Ile Lys Thr Leu Asp Glu Leu Lys Asn
Ala Leu 420 425 430 aaa taa 1302 Lys * 90 433 PRT Artificial
Sequence Chimeric protein 90 Met Ala Cys Asn Asn Ser Gly Lys Asp
Gly Asn Thr Ser Ala Asn Ser 1 5 10 15 Ala Asp Glu Ser Val Lys Gly
Pro Asn Leu Thr Glu Ile Ser Lys Lys 20 25 30 Ile Thr Asp Ser Asn
Ala Val Leu Leu Ala Val Lys Glu Val Glu Ala 35 40 45 Leu Leu Ser
Ser Ile Asp Glu Leu Ala Lys Ala Ile Gly Lys Lys Ile 50 55 60 Lys
Asn Asp Gly Ser Leu Asp Asn Glu Ala Asn Arg Asn Glu Ser Leu 65 70
75 80 Leu Ala Gly Ala Tyr Thr Ile Ser Thr Leu Ile Thr Gln Lys Leu
Ser 85 90 95 Lys Leu Asn Gly Ser Glu Gly Leu Lys Glu Lys Ile Ala
Ala Ala Lys 100 105 110 Lys Cys Ser Glu Glu Phe Ser Thr Lys Leu Lys
Asp Asn His Ala Gln 115 120 125 Leu Gly Ile Gln Gly Val Thr Asp Glu
Asn Ala Lys Lys Ala Ile Leu 130 135 140 Lys Ala Asn Ala Ala Gly Lys
Asp Lys Gly Val Glu Glu Leu Glu Lys 145 150 155 160 Leu Ser Gly Ser
Leu Glu Ser Leu Ser Lys Ala Ala Lys Glu Met Leu 165 170 175 Ala Asn
Ser Val Lys Glu Leu Thr Ser Pro Val Val His Gly Val Ser 180 185 190
Val Asp Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys Asn 195
200 205 Lys Asp Gly Lys Tyr Asp Leu Ile Ala Thr Val Asp Lys Leu Glu
Leu 210 215 220 Lys Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Val Leu
Glu Gly Val 225 230 235 240 Lys Ala Asp Lys Ser Lys Val Lys Leu Thr
Ile Ser Asp Asp Leu Gly 245 250 255 Gln Thr Thr Leu Glu Val Phe Lys
Glu Asp Gly Lys Thr Leu Val Ser 260 265 270 Lys Lys Val Thr Ser Lys
Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn 275 280 285 Glu Lys Gly Glu
Val Ser Glu Lys Ile Ile Thr Arg Ala Asp Gly Thr 290 295 300 Arg Leu
Glu Tyr Thr Gly Ile Lys Ser Asp Gly Ser Gly Lys Ala Lys 305 310 315
320 Glu Val Leu Lys Gly Phe Thr Leu Glu Gly Lys Val Ala Asn Asp Lys
325 330 335 Val Thr Leu Glu Val Lys Glu Gly Thr Val Thr Leu Ser Lys
Ile Ser 340 345 350 Lys Ser Gly Glu Val Ser Val Glu Leu Asn Asp Thr
Asp Ser Ser Ala 355 360 365 Ala Thr Lys Lys Thr Ala Ala Trp Asn Ser
Lys Thr Ser Thr Leu Thr 370 375 380 Ile Ser Val Asn Ser Lys Lys Thr
Thr Gln Leu Val Phe Thr Lys Gln 385 390 395 400 Asp Thr Ile Thr Val
Gln Lys Tyr Asp Ser Ala Gly Thr Asn Leu Glu 405 410 415 Gly Thr Ala
Val Glu Ile Lys Thr Leu Asp Glu Leu Lys Asn Ala Leu 420 425 430 Lys
91 31 DNA Artificial Sequence Oligonucleotide Primer 91 gtcatatggc
ttgtaataat tcagggaaag a 31 92 30 DNA Artificial Sequence
Oligonucleotide Primer 92 tttccatgga aggttttttt ggactttctg 30 93 30
DNA Artificial Sequence Oligonucleotide Primer 93 tttccatggc
caagcaaaat gttagcagcc 30 94 27 DNA Artificial Sequence
Oligonucleotide Primer 94 taaggatcct tattttaaag cgttttt 27 95 822
DNA Artificial Sequence Altered OspA Nucleic Acid 95 atg aaa aaa
tat tta ttg gga ata ggt cta ata tta gcc tta ata gca 48 Met Lys Lys
Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile Ala 1 5 10 15 tgt
aag caa aat gtt agc agc ctt gac gag aaa aac agc gtt tca gta 96 Cys
Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val Ser Val 20 25
30 gat ttg cct ggt gaa atg aaa gtt ctt gta agc aaa gaa aaa aac aaa
144 Asp Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys Asn Lys
35 40 45 gac ggc aag tac gat cta att gca aca gta gac aag ctt gag
ctt aaa 192 Asp Gly Lys Tyr Asp Leu Ile Ala Thr Val Asp Lys Leu Glu
Leu Lys 50 55 60 gga act tct gat aaa aac aat gga tct gga gta ctt
gaa ggc gta aaa 240 Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Val Leu
Glu Gly Val Lys 65 70 75 80 gct gac aaa agt aaa gta aaa tta aca att
tct gac gat cta ggt caa 288 Ala Asp Lys Ser Lys Val Lys Leu Thr Ile
Ser Asp Asp Leu Gly Gln 85 90 95 acc aca ctt gaa gtt ttc aaa gaa
gat ggc aaa aca cta gta tca aaa 336 Thr Thr Leu Glu Val Phe Lys Glu
Asp Gly Lys Thr Leu Val Ser Lys 100 105 110 aaa gta act tcc aaa gac
aag tca tca aca gaa gaa aaa ttc aat gaa 384 Lys Val Thr Ser Lys Asp
Lys Ser Ser Thr Glu Glu Lys Phe Asn Glu 115 120 125 aaa ggt gaa gta
tct gaa aaa ata ata aca atg gca gac gga acc aga 432 Lys Gly Glu Val
Ser Glu Lys Ile Ile Thr Met Ala Asp Gly Thr Arg 130 135 140 ctt gaa
tac aca gga att aaa agc gat gga tct gga aaa gct aaa gag 480 Leu Glu
Tyr Thr Gly Ile Lys Ser Asp Gly Ser Gly Lys Ala Lys Glu 145 150 155
160 gtt tta aaa ggc tat gtt ctt gaa gga act cta act gct gaa aaa aca
528 Val Leu Lys Gly Tyr Val Leu Glu Gly Thr Leu Thr Ala Glu Lys Thr
165 170 175 aca ttg gtg gtt aaa gaa gga act gtt act tta agc aaa aat
att tca 576 Thr Leu Val Val Lys Glu Gly Thr Val Thr Leu Ser Lys Asn
Ile Ser 180 185 190 aaa tct ggg gaa gtt tca gtt gaa ctt aat gac act
gac agt agt gct 624 Lys Ser Gly Glu Val Ser Val Glu Leu Asn Asp Thr
Asp Ser Ser Ala 195 200 205 gct act aaa aaa act gca gct tgg aat tca
ggc act tca act tta aca 672 Ala Thr Lys Lys Thr Ala Ala Trp Asn Ser
Gly Thr Ser Thr Leu Thr 210 215 220 att act gta aac agt aaa aaa act
aaa gac ctt gtg ttt aca aaa gaa 720 Ile Thr Val Asn Ser Lys Lys Thr
Lys Asp Leu Val Phe Thr Lys Glu 225 230 235 240 aac aca att aca gta
caa caa tac gac tca aat ggc acc aaa tta gag 768 Asn Thr Ile Thr Val
Gln Gln Tyr Asp Ser Asn Gly Thr Lys Leu Glu 245 250 255 ggg tca gca
gtt gaa att aca aaa ctt gat gaa att aaa aac gct tta 816 Gly Ser Ala
Val Glu Ile Thr Lys Leu Asp Glu Ile Lys Asn Ala Leu 260 265 270 aaa
taa 822 Lys * 96 273 PRT Artificial Sequence Altered OspA protein
96 Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile Ala
1 5 10 15 Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val
Ser Val 20 25 30 Asp Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys
Glu Lys Asn Lys 35 40 45 Asp Gly Lys Tyr Asp Leu Ile Ala Thr Val
Asp Lys Leu Glu Leu Lys 50 55 60 Gly Thr Ser Asp Lys Asn Asn Gly
Ser Gly Val Leu Glu Gly Val Lys 65 70 75 80 Ala Asp Lys Ser Lys Val
Lys Leu Thr Ile Ser Asp Asp Leu Gly Gln 85 90 95 Thr Thr Leu Glu
Val Phe Lys Glu Asp Gly Lys Thr Leu Val Ser Lys 100 105 110 Lys Val
Thr Ser Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn Glu 115 120 125
Lys Gly Glu Val Ser Glu Lys Ile Ile Thr Met Ala Asp Gly Thr Arg 130
135 140 Leu Glu Tyr Thr Gly Ile Lys Ser Asp Gly Ser Gly Lys Ala Lys
Glu 145 150 155 160 Val Leu Lys Gly Tyr Val Leu Glu Gly Thr Leu Thr
Ala Glu Lys Thr 165 170 175 Thr Leu Val Val Lys Glu Gly Thr Val Thr
Leu Ser Lys Asn Ile Ser 180 185 190 Lys Ser Gly Glu Val Ser Val Glu
Leu Asn Asp Thr Asp Ser Ser Ala 195 200 205 Ala Thr Lys Lys Thr Ala
Ala Trp Asn Ser Gly Thr Ser Thr Leu Thr 210 215 220 Ile Thr Val Asn
Ser Lys Lys Thr Lys Asp Leu Val Phe Thr Lys Glu 225 230 235 240 Asn
Thr Ile Thr Val Gln Gln Tyr Asp Ser Asn Gly Thr Lys Leu Glu 245 250
255 Gly Ser Ala Val Glu Ile Thr Lys Leu Asp Glu Ile Lys Asn Ala Leu
260 265 270 Lys 97 822 DNA Artificial Sequence Altered OspA Nucleic
Acid 97 atg aaa aaa tat tta ttg gga ata ggt cta ata tta gcc tta ata
gca 48 Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile
Ala 1 5 10 15 tgt aag caa aat gtt agc agc ctt gac gag aaa aac agc
gtt tca gta 96 Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser
Val Ser Val 20 25 30 gat ttg cct ggt gaa atg aaa gtt ctt gta agc
aaa gaa aaa aac aaa 144 Asp Leu Pro Gly Glu Met Lys Val Leu Val Ser
Lys Glu Lys Asn Lys 35 40 45 gac ggc aag tac gat cta att gca aca
gta gac aag ctt gag ctt aaa 192 Asp Gly Lys Tyr Asp Leu Ile Ala Thr
Val Asp Lys Leu Glu Leu Lys 50 55 60 gga act tct gat aaa aac aat
gga tct gga gta ctt gaa ggc gta aaa 240 Gly Thr Ser Asp Lys Asn Asn
Gly Ser Gly Val Leu Glu Gly Val Lys 65 70 75 80 gct gac aaa agt aaa
gta aaa tta aca att tct gac gat cta ggt caa 288 Ala Asp Lys Ser Lys
Val Lys Leu Thr Ile Ser Asp Asp Leu Gly Gln 85 90 95 acc aca ctt
gaa gtt ttc aaa gaa gat ggc aaa aca cta gta tca aaa 336 Thr Thr Leu
Glu Val Phe Lys Glu Asp Gly Lys Thr Leu Val Ser Lys 100 105 110 aaa
gta act tcc aaa gac aag tca tca aca gaa gaa aaa ttc aat gaa 384 Lys
Val Thr Ser Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn Glu 115 120
125 aaa ggt gaa gta tct gaa aaa ata ata aca aga gca gac gga acc aga
432 Lys Gly Glu Val Ser Glu Lys Ile Ile Thr Arg Ala Asp Gly Thr Arg
130 135 140 ctt gaa tac aca gga att aaa agc gat gga tct gga aaa gct
aaa tat 480 Leu Glu Tyr Thr Gly Ile Lys Ser Asp Gly Ser Gly Lys Ala
Lys Tyr 145 150 155 160 gtt tta aaa ggc tat gtt ctt gaa gga act cta
act gct gaa aaa aca 528 Val Leu Lys Gly Tyr Val Leu Glu Gly Thr Leu
Thr Ala Glu Lys Thr 165 170 175 aca ttg gtg gtt aaa gaa gga act gtt
act tta agc aaa aat att tca 576 Thr Leu Val Val Lys Glu Gly Thr Val
Thr Leu Ser Lys Asn Ile Ser 180 185 190 aaa tct ggg gaa gtt tca gtt
gaa ctt aat gac act gac agt agt gct 624 Lys Ser Gly Glu Val Ser Val
Glu Leu Asn Asp Thr Asp Ser Ser Ala 195 200 205 gct act aaa aaa act
gca gct tgg aat tca ggc act tca act tta aca 672 Ala Thr Lys Lys Thr
Ala Ala Trp Asn Ser Gly Thr Ser Thr Leu Thr 210 215 220 att act gta
aac agt aaa aaa act aaa gac ctt gtg ttt aca aaa gaa 720 Ile Thr Val
Asn Ser Lys Lys Thr Lys Asp Leu Val Phe Thr Lys Glu 225 230 235 240
aac aca att aca gta caa caa tac gac tca aat ggc acc aaa tta gag 768
Asn Thr Ile Thr Val Gln Gln Tyr Asp Ser Asn Gly Thr Lys Leu Glu 245
250 255 ggg tca gca gtt gaa att aca aaa ctt gat gaa att aaa aac gct
tta 816 Gly Ser Ala Val Glu Ile Thr Lys Leu Asp Glu Ile Lys Asn Ala
Leu 260 265 270 aaa taa 822 Lys * 98 273 PRT Artificial Sequence
Altered OspA protein 98 Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile
Leu Ala Leu Ile Ala 1 5 10 15 Cys Lys Gln Asn Val Ser Ser Leu Asp
Glu Lys Asn Ser Val Ser Val 20 25 30 Asp Leu Pro Gly Glu Met Lys
Val Leu Val Ser Lys Glu Lys Asn Lys 35 40 45 Asp Gly Lys Tyr Asp
Leu Ile Ala Thr Val Asp Lys Leu Glu Leu Lys 50 55 60 Gly Thr Ser
Asp Lys Asn Asn Gly Ser Gly Val Leu Glu Gly Val Lys 65 70 75 80 Ala
Asp Lys Ser Lys Val Lys Leu Thr Ile Ser Asp Asp Leu Gly Gln 85 90
95 Thr Thr Leu Glu Val Phe Lys Glu Asp Gly Lys Thr Leu Val Ser Lys
100 105 110 Lys Val Thr Ser Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe
Asn Glu 115 120 125 Lys Gly Glu Val Ser Glu Lys Ile Ile Thr Arg Ala
Asp Gly Thr Arg 130 135 140 Leu Glu Tyr Thr Gly Ile Lys Ser Asp Gly
Ser Gly Lys Ala Lys Tyr 145 150 155 160 Val Leu Lys Gly Tyr Val Leu
Glu Gly Thr Leu Thr Ala Glu Lys Thr 165 170 175 Thr Leu Val Val Lys
Glu Gly Thr Val Thr Leu Ser Lys Asn Ile Ser 180 185 190 Lys Ser Gly
Glu Val Ser Val Glu Leu Asn Asp Thr Asp Ser Ser Ala 195 200 205 Ala
Thr Lys Lys Thr Ala Ala Trp Asn Ser Gly Thr Ser Thr Leu Thr 210 215
220 Ile Thr Val Asn Ser Lys Lys Thr Lys Asp Leu Val Phe Thr Lys Glu
225 230 235 240 Asn Thr Ile Thr Val Gln Gln Tyr Asp Ser Asn Gly Thr
Lys Leu Glu 245 250 255 Gly Ser Ala Val Glu Ile Thr Lys Leu Asp Glu
Ile Lys Asn Ala Leu 260 265 270 Lys 99 822 DNA Artificial Sequence
Altered OspA Nucleic Acid 99 atg aaa aaa tat tta ttg gga ata ggt
cta ata tta gcc tta ata gca 48 Met Lys Lys Tyr Leu Leu Gly Ile Gly
Leu Ile Leu Ala Leu Ile Ala 1 5 10 15 tgt aag caa aat gtt agc agc
ctt gac gag aaa aac agc gtt tca gta 96 Cys Lys Gln Asn Val Ser Ser
Leu Asp Glu Lys Asn Ser Val Ser Val 20 25 30 gat ttg cct ggt gaa
atg aaa gtt ctt gta agc aaa gaa aaa aac aaa 144 Asp Leu Pro Gly Glu
Met Lys Val Leu Val Ser Lys Glu Lys Asn Lys 35 40 45 gac ggc aag
tac gat cta att gca aca gta gac aag ctt gag ctt aaa 192 Asp Gly Lys
Tyr Asp Leu Ile Ala Thr Val Asp Lys Leu Glu Leu Lys 50 55 60 gga
act tct gat aaa aac aat gga tct gga gta ctt gaa ggc gta aaa 240 Gly
Thr Ser Asp Lys Asn Asn Gly Ser Gly Val Leu Glu Gly Val Lys 65 70
75 80 gct gac aaa agt aaa gta aaa tta aca att tct gac gat cta ggt
caa 288 Ala Asp Lys Ser Lys Val Lys Leu Thr Ile Ser Asp Asp Leu Gly
Gln 85 90 95 acc aca ctt gaa gtt ttc aaa gaa gat ggc aaa aca cta
gta tca aaa 336 Thr Thr Leu Glu Val Phe Lys Glu Asp Gly Lys Thr Leu
Val Ser Lys 100 105 110 aaa gta act tcc aaa gac aag tca tca aca gaa
gaa aaa ttc aat gaa 384 Lys Val Thr Ser Lys Asp Lys Ser Ser Thr Glu
Glu Lys Phe Asn Glu 115 120 125 aaa ggt gaa gta tct gaa aaa ata ata
aca atg gca gac gga acc aga 432 Lys Gly Glu Val Ser Glu Lys Ile Ile
Thr Met Ala Asp Gly Thr Arg 130 135 140 ctt gaa tac aca gga att aaa
agc gat gga tct gga aaa gct aaa tat 480 Leu Glu Tyr Thr Gly Ile Lys
Ser Asp Gly Ser Gly Lys Ala Lys Tyr 145 150 155 160 gtt tta aaa ggc
tat gtt ctt gaa gga act cta act gct gaa aaa aca 528 Val Leu Lys Gly
Tyr Val Leu Glu Gly Thr Leu Thr Ala Glu Lys Thr 165 170
175 aca ttg gtg gtt aaa gaa gga act gtt act tta agc aaa aat att tca
576 Thr Leu Val Val Lys Glu Gly Thr Val Thr Leu Ser Lys Asn Ile Ser
180 185 190 aaa tct ggg gaa gtt tca gtt gaa ctt aat gac act gac agt
agt gct 624 Lys Ser Gly Glu Val Ser Val Glu Leu Asn Asp Thr Asp Ser
Ser Ala 195 200 205 gct act aaa aaa act gca gct tgg aat tca ggc act
tca act tta aca 672 Ala Thr Lys Lys Thr Ala Ala Trp Asn Ser Gly Thr
Ser Thr Leu Thr 210 215 220 att act gta aac agt aaa aaa act aaa gac
ctt gtg ttt aca aaa gaa 720 Ile Thr Val Asn Ser Lys Lys Thr Lys Asp
Leu Val Phe Thr Lys Glu 225 230 235 240 aac aca att aca gta caa caa
tac gac tca aat ggc acc aaa tta gag 768 Asn Thr Ile Thr Val Gln Gln
Tyr Asp Ser Asn Gly Thr Lys Leu Glu 245 250 255 ggg tca gca gtt gaa
att aca aaa ctt gat gaa att aaa aac gct tta 816 Gly Ser Ala Val Glu
Ile Thr Lys Leu Asp Glu Ile Lys Asn Ala Leu 260 265 270 aaa taa 822
Lys * 100 273 PRT Artificial Sequence Altered OspA Protein 100 Met
Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile Ala 1 5 10
15 Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val Ser Val
20 25 30 Asp Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys
Asn Lys 35 40 45 Asp Gly Lys Tyr Asp Leu Ile Ala Thr Val Asp Lys
Leu Glu Leu Lys 50 55 60 Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly
Val Leu Glu Gly Val Lys 65 70 75 80 Ala Asp Lys Ser Lys Val Lys Leu
Thr Ile Ser Asp Asp Leu Gly Gln 85 90 95 Thr Thr Leu Glu Val Phe
Lys Glu Asp Gly Lys Thr Leu Val Ser Lys 100 105 110 Lys Val Thr Ser
Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn Glu 115 120 125 Lys Gly
Glu Val Ser Glu Lys Ile Ile Thr Met Ala Asp Gly Thr Arg 130 135 140
Leu Glu Tyr Thr Gly Ile Lys Ser Asp Gly Ser Gly Lys Ala Lys Tyr 145
150 155 160 Val Leu Lys Gly Tyr Val Leu Glu Gly Thr Leu Thr Ala Glu
Lys Thr 165 170 175 Thr Leu Val Val Lys Glu Gly Thr Val Thr Leu Ser
Lys Asn Ile Ser 180 185 190 Lys Ser Gly Glu Val Ser Val Glu Leu Asn
Asp Thr Asp Ser Ser Ala 195 200 205 Ala Thr Lys Lys Thr Ala Ala Trp
Asn Ser Gly Thr Ser Thr Leu Thr 210 215 220 Ile Thr Val Asn Ser Lys
Lys Thr Lys Asp Leu Val Phe Thr Lys Glu 225 230 235 240 Asn Thr Ile
Thr Val Gln Gln Tyr Asp Ser Asn Gly Thr Lys Leu Glu 245 250 255 Gly
Ser Ala Val Glu Ile Thr Lys Leu Asp Glu Ile Lys Asn Ala Leu 260 265
270 Lys 101 822 DNA Artificial Sequence Altered OspA Nucleic Acid
101 atg aaa aaa tat tta ttg gga ata ggt cta ata tta gcc tta ata gca
48 Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile Ala
1 5 10 15 tgt aag caa aat gtt agc agc ctt gac gag aaa aac agc gtt
tca gta 96 Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val
Ser Val 20 25 30 gat ttg cct ggt gaa atg aaa gtt ctt gta agc aaa
gaa aaa aac aaa 144 Asp Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys
Glu Lys Asn Lys 35 40 45 gac ggc aag tac gat cta att gca aca gta
gac aag ctt gag ctt aaa 192 Asp Gly Lys Tyr Asp Leu Ile Ala Thr Val
Asp Lys Leu Glu Leu Lys 50 55 60 gga act tct gat aaa aac aat gga
tct gga gta ctt gaa ggc gta aaa 240 Gly Thr Ser Asp Lys Asn Asn Gly
Ser Gly Val Leu Glu Gly Val Lys 65 70 75 80 gct gac aaa agt aaa gta
aaa tta aca att tct gac gat cta ggt caa 288 Ala Asp Lys Ser Lys Val
Lys Leu Thr Ile Ser Asp Asp Leu Gly Gln 85 90 95 acc aca ctt gaa
gtt ttc aaa gaa gat ggc aaa aca cta gta tca aaa 336 Thr Thr Leu Glu
Val Phe Lys Glu Asp Gly Lys Thr Leu Val Ser Lys 100 105 110 aaa gta
act tcc aaa gac aag tca tca aca gaa gaa aaa ttc aat gaa 384 Lys Val
Thr Ser Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn Glu 115 120 125
aaa ggt gaa gta tct gaa aaa ata ata aca aga gca gac gga acc aga 432
Lys Gly Glu Val Ser Glu Lys Ile Ile Thr Arg Ala Asp Gly Thr Arg 130
135 140 ctt gaa tac aca gga att aaa agc gat gga tct gga aaa gct aaa
tat 480 Leu Glu Tyr Thr Gly Ile Lys Ser Asp Gly Ser Gly Lys Ala Lys
Tyr 145 150 155 160 gtt tta aaa ggc tat gtt ctt gaa gga act cta act
gct gaa aaa aca 528 Val Leu Lys Gly Tyr Val Leu Glu Gly Thr Leu Thr
Ala Glu Lys Thr 165 170 175 aca ttg gtg gtt aaa gaa gga act gtt act
tta agc aaa aat att tca 576 Thr Leu Val Val Lys Glu Gly Thr Val Thr
Leu Ser Lys Asn Ile Ser 180 185 190 aaa tct ggg gaa gtt tca gtt gaa
ctt aat gac act gac agt agt gct 624 Lys Ser Gly Glu Val Ser Val Glu
Leu Asn Asp Thr Asp Ser Ser Ala 195 200 205 gct act aaa aaa act gca
gct tgg aat tca ggc act tca act tta aca 672 Ala Thr Lys Lys Thr Ala
Ala Trp Asn Ser Gly Thr Ser Thr Leu Thr 210 215 220 att act gta aac
agt aaa aaa act aaa gac ctt gtg ttt aca aaa gaa 720 Ile Thr Val Asn
Ser Lys Lys Thr Lys Asp Leu Val Phe Thr Lys Glu 225 230 235 240 aac
aca att aca gta caa caa tac gac tca aat ggc acc aaa tta gag 768 Asn
Thr Ile Thr Val Gln Gln Tyr Asp Ser Asn Gly Thr Lys Leu Glu 245 250
255 ggg tca gca gtt gaa att aca aaa ctt gat gaa att aaa aac gct tta
816 Gly Ser Ala Val Glu Ile Thr Lys Leu Asp Glu Ile Lys Asn Ala Leu
260 265 270 aaa taa 822 Lys * 102 273 PRT Artificial Sequence
Altered OspA Protein 102 Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu
Ile Leu Ala Leu Ile Ala 1 5 10 15 Cys Lys Gln Asn Val Ser Ser Leu
Asp Glu Lys Asn Ser Val Ser Val 20 25 30 Asp Leu Pro Gly Glu Met
Lys Val Leu Val Ser Lys Glu Lys Asn Lys 35 40 45 Asp Gly Lys Tyr
Asp Leu Ile Ala Thr Val Asp Lys Leu Glu Leu Lys 50 55 60 Gly Thr
Ser Asp Lys Asn Asn Gly Ser Gly Val Leu Glu Gly Val Lys 65 70 75 80
Ala Asp Lys Ser Lys Val Lys Leu Thr Ile Ser Asp Asp Leu Gly Gln 85
90 95 Thr Thr Leu Glu Val Phe Lys Glu Asp Gly Lys Thr Leu Val Ser
Lys 100 105 110 Lys Val Thr Ser Lys Asp Lys Ser Ser Thr Glu Glu Lys
Phe Asn Glu 115 120 125 Lys Gly Glu Val Ser Glu Lys Ile Ile Thr Arg
Ala Asp Gly Thr Arg 130 135 140 Leu Glu Tyr Thr Gly Ile Lys Ser Asp
Gly Ser Gly Lys Ala Lys Tyr 145 150 155 160 Val Leu Lys Gly Tyr Val
Leu Glu Gly Thr Leu Thr Ala Glu Lys Thr 165 170 175 Thr Leu Val Val
Lys Glu Gly Thr Val Thr Leu Ser Lys Asn Ile Ser 180 185 190 Lys Ser
Gly Glu Val Ser Val Glu Leu Asn Asp Thr Asp Ser Ser Ala 195 200 205
Ala Thr Lys Lys Thr Ala Ala Trp Asn Ser Gly Thr Ser Thr Leu Thr 210
215 220 Ile Thr Val Asn Ser Lys Lys Thr Lys Asp Leu Val Phe Thr Lys
Glu 225 230 235 240 Asn Thr Ile Thr Val Gln Gln Tyr Asp Ser Asn Gly
Thr Lys Leu Glu 245 250 255 Gly Ser Ala Val Glu Ile Thr Lys Leu Asp
Glu Ile Lys Asn Ala Leu 260 265 270 Lys 103 822 DNA Artificial
Sequence Altered OspA Nucleic Acid 103 atg aaa aaa tat tta ttg gga
ata ggt cta ata tta gcc tta ata gca 48 Met Lys Lys Tyr Leu Leu Gly
Ile Gly Leu Ile Leu Ala Leu Ile Ala 1 5 10 15 tgt aag caa aat gtt
agc agc ctt gac gag aaa aac agc gtt tca gta 96 Cys Lys Gln Asn Val
Ser Ser Leu Asp Glu Lys Asn Ser Val Ser Val 20 25 30 gat ttg cct
ggt gaa atg aaa gtt ctt gta agc aaa gaa aaa aac aaa 144 Asp Leu Pro
Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys Asn Lys 35 40 45 gac
ggc aag tac gat cta att gca aca gta gac aag ctt gag ctt aaa 192 Asp
Gly Lys Tyr Asp Leu Ile Ala Thr Val Asp Lys Leu Glu Leu Lys 50 55
60 gga act tct gat aaa aac aat gga tct gga gta ctt gaa ggc gta aaa
240 Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Val Leu Glu Gly Val Lys
65 70 75 80 gct gac aaa agt aaa gta aaa tta aca att tct gac gat cta
ggt caa 288 Ala Asp Lys Ser Lys Val Lys Leu Thr Ile Ser Asp Asp Leu
Gly Gln 85 90 95 acc aca ctt gaa gtt ttc aaa gaa gat ggc aaa aca
cta gta tca aaa 336 Thr Thr Leu Glu Val Phe Lys Glu Asp Gly Lys Thr
Leu Val Ser Lys 100 105 110 aaa gta act tcc aaa gac aag tca tca aca
gaa gaa aaa ttc aat gaa 384 Lys Val Thr Ser Lys Asp Lys Ser Ser Thr
Glu Glu Lys Phe Asn Glu 115 120 125 aaa ggt gaa gta tct gaa aaa ata
ata aca atg gca gac gga acc aga 432 Lys Gly Glu Val Ser Glu Lys Ile
Ile Thr Met Ala Asp Gly Thr Arg 130 135 140 ctt gaa tac aca gga att
aaa agc gat gga tct gga aaa gct aaa tat 480 Leu Glu Tyr Thr Gly Ile
Lys Ser Asp Gly Ser Gly Lys Ala Lys Tyr 145 150 155 160 gtt tta aaa
ggc tat gtt ctt gaa gga act cta act gct gaa aaa aca 528 Val Leu Lys
Gly Tyr Val Leu Glu Gly Thr Leu Thr Ala Glu Lys Thr 165 170 175 aca
ttg gtg gtt aaa gaa gga act gtt act tta agc aaa aat att tca 576 Thr
Leu Val Val Lys Glu Gly Thr Val Thr Leu Ser Lys Asn Ile Ser 180 185
190 aaa tct ggg gaa gtt tca gtt gaa ctt aat gac act gac agt agt gct
624 Lys Ser Gly Glu Val Ser Val Glu Leu Asn Asp Thr Asp Ser Ser Ala
195 200 205 gct act aaa aaa act gca gct tgg aat tca ggc act tca act
tta aca 672 Ala Thr Lys Lys Thr Ala Ala Trp Asn Ser Gly Thr Ser Thr
Leu Thr 210 215 220 att act gta aac agt aaa aaa act aaa gac ctt gtg
ttt aca aaa gaa 720 Ile Thr Val Asn Ser Lys Lys Thr Lys Asp Leu Val
Phe Thr Lys Glu 225 230 235 240 aac aca att aca gta caa caa tac gac
tca aat ggc acc aaa tta gag 768 Asn Thr Ile Thr Val Gln Gln Tyr Asp
Ser Asn Gly Thr Lys Leu Glu 245 250 255 ggg tca gca gtt gaa att aca
aaa ctt gat gaa att aaa aac gct tta 816 Gly Ser Ala Val Glu Ile Thr
Lys Leu Asp Glu Ile Lys Asn Ala Leu 260 265 270 aaa taa 822 Lys *
104 273 PRT Artificial Sequence Altered OspA Protein 104 Met Lys
Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile Ala 1 5 10 15
Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val Ser Val 20
25 30 Asp Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys Asn
Lys 35 40 45 Asp Gly Lys Tyr Asp Leu Ile Ala Thr Val Asp Lys Leu
Glu Leu Lys 50 55 60 Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Val
Leu Glu Gly Val Lys 65 70 75 80 Ala Asp Lys Ser Lys Val Lys Leu Thr
Ile Ser Asp Asp Leu Gly Gln 85 90 95 Thr Thr Leu Glu Val Phe Lys
Glu Asp Gly Lys Thr Leu Val Ser Lys 100 105 110 Lys Val Thr Ser Lys
Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn Glu 115 120 125 Lys Gly Glu
Val Ser Glu Lys Ile Ile Thr Met Ala Asp Gly Thr Arg 130 135 140 Leu
Glu Tyr Thr Gly Ile Lys Ser Asp Gly Ser Gly Lys Ala Lys Tyr 145 150
155 160 Val Leu Lys Gly Tyr Val Leu Glu Gly Thr Leu Thr Ala Glu Lys
Thr 165 170 175 Thr Leu Val Val Lys Glu Gly Thr Val Thr Leu Ser Lys
Asn Ile Ser 180 185 190 Lys Ser Gly Glu Val Ser Val Glu Leu Asn Asp
Thr Asp Ser Ser Ala 195 200 205 Ala Thr Lys Lys Thr Ala Ala Trp Asn
Ser Gly Thr Ser Thr Leu Thr 210 215 220 Ile Thr Val Asn Ser Lys Lys
Thr Lys Asp Leu Val Phe Thr Lys Glu 225 230 235 240 Asn Thr Ile Thr
Val Gln Gln Tyr Asp Ser Asn Gly Thr Lys Leu Glu 245 250 255 Gly Ser
Ala Val Glu Ile Thr Lys Leu Asp Glu Ile Lys Asn Ala Leu 260 265 270
Lys 105 822 DNA Artificial Sequence Altered OspA Nucleic Acid 105
atg aaa aaa tat tta ttg gga ata ggt cta ata tta gcc tta ata gca 48
Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile Ala 1 5
10 15 tgt aag caa aat gtt agc agc ctt gac gag aaa aac agc gtt tca
gta 96 Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val Ser
Val 20 25 30 gat ttg cct ggt gaa atg aaa gtt ctt gta agc aaa gaa
aaa aac aaa 144 Asp Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys Glu
Lys Asn Lys 35 40 45 gac ggc aag tac gat cta att gca aca gta gac
aag ctt gag ctt aaa 192 Asp Gly Lys Tyr Asp Leu Ile Ala Thr Val Asp
Lys Leu Glu Leu Lys 50 55 60 gga act tct gat aaa aac aat gga tct
gga gta ctt gaa ggc gta aaa 240 Gly Thr Ser Asp Lys Asn Asn Gly Ser
Gly Val Leu Glu Gly Val Lys 65 70 75 80 gct gac aaa agt aaa gta aaa
tta aca att tct gac gat cta ggt caa 288 Ala Asp Lys Ser Lys Val Lys
Leu Thr Ile Ser Asp Asp Leu Gly Gln 85 90 95 acc aca ctt gaa gtt
ttc aaa gaa gat ggc aaa aca cta gta tca aaa 336 Thr Thr Leu Glu Val
Phe Lys Glu Asp Gly Lys Thr Leu Val Ser Lys 100 105 110 aaa gta act
tcc aaa gac aag tca tca aca gaa gaa aaa ttc aat gaa 384 Lys Val Thr
Ser Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn Glu 115 120 125 aaa
ggt gaa gta tct gaa aaa ata ata aca aga gca gac gga acc aga 432 Lys
Gly Glu Val Ser Glu Lys Ile Ile Thr Arg Ala Asp Gly Thr Arg 130 135
140 ctt gaa tac aca gga att aaa agc gat gga tct gga aaa gct aaa gag
480 Leu Glu Tyr Thr Gly Ile Lys Ser Asp Gly Ser Gly Lys Ala Lys Glu
145 150 155 160 gtt tta aaa ggc ttt gtt ctt gaa gga act cta act gct
gaa aaa aca 528 Val Leu Lys Gly Phe Val Leu Glu Gly Thr Leu Thr Ala
Glu Lys Thr 165 170 175 aca ttg gtg gtt aaa gaa gga act gtt act tta
agc aaa aat att tca 576 Thr Leu Val Val Lys Glu Gly Thr Val Thr Leu
Ser Lys Asn Ile Ser 180 185 190 aaa tct ggg gaa gtt tca gtt gaa ctt
aat gac act gac agt agt gct 624 Lys Ser Gly Glu Val Ser Val Glu Leu
Asn Asp Thr Asp Ser Ser Ala 195 200 205 gct act aaa aaa act gca gct
tgg aat tca ggc act tca act tta aca 672 Ala Thr Lys Lys Thr Ala Ala
Trp Asn Ser Gly Thr Ser Thr Leu Thr 210 215 220 att act gta aac agt
aaa aaa act aaa gac ctt gtg ttt aca aaa gaa 720 Ile Thr Val Asn Ser
Lys Lys Thr Lys Asp Leu Val Phe Thr Lys Glu 225 230 235 240 aac aca
att aca gta caa caa tac gac tca aat ggc acc aaa tta gag 768 Asn Thr
Ile Thr Val Gln Gln Tyr Asp Ser Asn Gly Thr Lys Leu Glu 245 250 255
ggg tca gca gtt gaa att aca aaa ctt gat gaa att aaa aac gct tta 816
Gly Ser Ala Val Glu Ile Thr Lys Leu Asp Glu Ile Lys Asn Ala Leu 260
265 270 aaa taa 822 Lys * 106 273 PRT Artificial Sequence Altered
OspA protein 106 Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu
Ala Leu Ile Ala 1 5 10 15 Cys Lys Gln Asn Val Ser Ser Leu Asp Glu
Lys Asn Ser Val Ser Val 20 25 30 Asp Leu Pro Gly Glu Met Lys Val
Leu Val Ser Lys Glu Lys Asn Lys 35 40 45 Asp Gly Lys Tyr Asp Leu
Ile Ala Thr Val Asp Lys Leu Glu Leu Lys 50 55
60 Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Val Leu Glu Gly Val Lys
65 70 75 80 Ala Asp Lys Ser Lys Val Lys Leu Thr Ile Ser Asp Asp Leu
Gly Gln 85 90 95 Thr Thr Leu Glu Val Phe Lys Glu Asp Gly Lys Thr
Leu Val Ser Lys 100 105 110 Lys Val Thr Ser Lys Asp Lys Ser Ser Thr
Glu Glu Lys Phe Asn Glu 115 120 125 Lys Gly Glu Val Ser Glu Lys Ile
Ile Thr Arg Ala Asp Gly Thr Arg 130 135 140 Leu Glu Tyr Thr Gly Ile
Lys Ser Asp Gly Ser Gly Lys Ala Lys Glu 145 150 155 160 Val Leu Lys
Gly Phe Val Leu Glu Gly Thr Leu Thr Ala Glu Lys Thr 165 170 175 Thr
Leu Val Val Lys Glu Gly Thr Val Thr Leu Ser Lys Asn Ile Ser 180 185
190 Lys Ser Gly Glu Val Ser Val Glu Leu Asn Asp Thr Asp Ser Ser Ala
195 200 205 Ala Thr Lys Lys Thr Ala Ala Trp Asn Ser Gly Thr Ser Thr
Leu Thr 210 215 220 Ile Thr Val Asn Ser Lys Lys Thr Lys Asp Leu Val
Phe Thr Lys Glu 225 230 235 240 Asn Thr Ile Thr Val Gln Gln Tyr Asp
Ser Asn Gly Thr Lys Leu Glu 245 250 255 Gly Ser Ala Val Glu Ile Thr
Lys Leu Asp Glu Ile Lys Asn Ala Leu 260 265 270 Lys 107 822 DNA
Artificial Sequence Altered OspA Nucleic Acid 107 atg aaa aaa tat
tta ttg gga ata ggt cta ata tta gcc tta ata gca 48 Met Lys Lys Tyr
Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile Ala 1 5 10 15 tgt aag
caa aat gtt agc agc ctt gac gag aaa aac agc gtt tca gta 96 Cys Lys
Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val Ser Val 20 25 30
gat ttg cct ggt gaa atg aaa gtt ctt gta agc aaa gaa aaa aac aaa 144
Asp Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys Asn Lys 35
40 45 gac ggc aag tac gat cta att gca aca gta gac aag ctt gag ctt
aaa 192 Asp Gly Lys Tyr Asp Leu Ile Ala Thr Val Asp Lys Leu Glu Leu
Lys 50 55 60 gga act tct gat aaa aac aat gga tct gga gta ctt gaa
ggc gta aaa 240 Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Val Leu Glu
Gly Val Lys 65 70 75 80 gct gac aaa agt aaa gta aaa tta aca att tct
gac gat cta ggt caa 288 Ala Asp Lys Ser Lys Val Lys Leu Thr Ile Ser
Asp Asp Leu Gly Gln 85 90 95 acc aca ctt gaa gtt ttc aaa gaa gat
ggc aaa aca cta gta tca aaa 336 Thr Thr Leu Glu Val Phe Lys Glu Asp
Gly Lys Thr Leu Val Ser Lys 100 105 110 aaa gta act tcc aaa gac aag
tca tca aca gaa gaa aaa ttc aat gaa 384 Lys Val Thr Ser Lys Asp Lys
Ser Ser Thr Glu Glu Lys Phe Asn Glu 115 120 125 aaa ggt gaa gta tct
gaa aaa ata ata aca aga gca gac gga acc aga 432 Lys Gly Glu Val Ser
Glu Lys Ile Ile Thr Arg Ala Asp Gly Thr Arg 130 135 140 ctt gaa tac
aca gga att aaa agc gat gga tct gga aaa gct aaa gag 480 Leu Glu Tyr
Thr Gly Ile Lys Ser Asp Gly Ser Gly Lys Ala Lys Glu 145 150 155 160
gtt tta aaa ggc ttt act ctt gaa gga act cta act gct gaa aaa aca 528
Val Leu Lys Gly Phe Thr Leu Glu Gly Thr Leu Thr Ala Glu Lys Thr 165
170 175 aca ttg gtg gtt aaa gaa gga act gtt act tta agc aaa aat att
tca 576 Thr Leu Val Val Lys Glu Gly Thr Val Thr Leu Ser Lys Asn Ile
Ser 180 185 190 aaa tct ggg gaa gtt tca gtt gaa ctt aat gac act gac
agt agt gct 624 Lys Ser Gly Glu Val Ser Val Glu Leu Asn Asp Thr Asp
Ser Ser Ala 195 200 205 gct act aaa aaa act gca gct tgg aat tca ggc
act tca act tta aca 672 Ala Thr Lys Lys Thr Ala Ala Trp Asn Ser Gly
Thr Ser Thr Leu Thr 210 215 220 att act gta aac agt aaa aaa act aaa
gac ctt gtg ttt aca aaa gaa 720 Ile Thr Val Asn Ser Lys Lys Thr Lys
Asp Leu Val Phe Thr Lys Glu 225 230 235 240 aac aca att aca gta caa
caa tac gac tca aat ggc acc aaa tta gag 768 Asn Thr Ile Thr Val Gln
Gln Tyr Asp Ser Asn Gly Thr Lys Leu Glu 245 250 255 ggg tca gca gtt
gaa att aca aaa ctt gat gaa att aaa aac gct tta 816 Gly Ser Ala Val
Glu Ile Thr Lys Leu Asp Glu Ile Lys Asn Ala Leu 260 265 270 aaa taa
822 Lys * 108 273 PRT Artificial Sequence Altered OspA Protein 108
Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile Ala 1 5
10 15 Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val Ser
Val 20 25 30 Asp Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys Glu
Lys Asn Lys 35 40 45 Asp Gly Lys Tyr Asp Leu Ile Ala Thr Val Asp
Lys Leu Glu Leu Lys 50 55 60 Gly Thr Ser Asp Lys Asn Asn Gly Ser
Gly Val Leu Glu Gly Val Lys 65 70 75 80 Ala Asp Lys Ser Lys Val Lys
Leu Thr Ile Ser Asp Asp Leu Gly Gln 85 90 95 Thr Thr Leu Glu Val
Phe Lys Glu Asp Gly Lys Thr Leu Val Ser Lys 100 105 110 Lys Val Thr
Ser Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn Glu 115 120 125 Lys
Gly Glu Val Ser Glu Lys Ile Ile Thr Arg Ala Asp Gly Thr Arg 130 135
140 Leu Glu Tyr Thr Gly Ile Lys Ser Asp Gly Ser Gly Lys Ala Lys Glu
145 150 155 160 Val Leu Lys Gly Phe Thr Leu Glu Gly Thr Leu Thr Ala
Glu Lys Thr 165 170 175 Thr Leu Val Val Lys Glu Gly Thr Val Thr Leu
Ser Lys Asn Ile Ser 180 185 190 Lys Ser Gly Glu Val Ser Val Glu Leu
Asn Asp Thr Asp Ser Ser Ala 195 200 205 Ala Thr Lys Lys Thr Ala Ala
Trp Asn Ser Gly Thr Ser Thr Leu Thr 210 215 220 Ile Thr Val Asn Ser
Lys Lys Thr Lys Asp Leu Val Phe Thr Lys Glu 225 230 235 240 Asn Thr
Ile Thr Val Gln Gln Tyr Asp Ser Asn Gly Thr Lys Leu Glu 245 250 255
Gly Ser Ala Val Glu Ile Thr Lys Leu Asp Glu Ile Lys Asn Ala Leu 260
265 270 Lys 109 822 DNA Artificial Sequence Altered OspA Nucleic
Acid 109 atg aaa aaa tat tta ttg gga ata ggt cta ata tta gcc tta
ata gca 48 Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu
Ile Ala 1 5 10 15 tgt aag caa aat gtt agc agc ctt gac gag aaa aac
agc gtt tca gta 96 Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn
Ser Val Ser Val 20 25 30 gat ttg cct ggt gaa atg aaa gtt ctt gta
agc aaa gaa aaa aac aaa 144 Asp Leu Pro Gly Glu Met Lys Val Leu Val
Ser Lys Glu Lys Asn Lys 35 40 45 gac ggc aag tac gat cta att gca
aca gta gac aag ctt gag ctt aaa 192 Asp Gly Lys Tyr Asp Leu Ile Ala
Thr Val Asp Lys Leu Glu Leu Lys 50 55 60 gga act tct gat aaa aac
aat gga tct gga gta ctt gaa ggc gta aaa 240 Gly Thr Ser Asp Lys Asn
Asn Gly Ser Gly Val Leu Glu Gly Val Lys 65 70 75 80 gct gac aaa agt
aaa gta aaa tta aca att tct gac gat cta ggt caa 288 Ala Asp Lys Ser
Lys Val Lys Leu Thr Ile Ser Asp Asp Leu Gly Gln 85 90 95 acc aca
ctt gaa gtt ttc aaa gaa gat ggc aaa aca cta gta tca aaa 336 Thr Thr
Leu Glu Val Phe Lys Glu Asp Gly Lys Thr Leu Val Ser Lys 100 105 110
aaa gta act tcc aaa gac aag tca tca aca gaa gaa aaa ttc aat gaa 384
Lys Val Thr Ser Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn Glu 115
120 125 aaa ggt gaa gta tct gaa aaa ata ata aca aga gca gac gga acc
aga 432 Lys Gly Glu Val Ser Glu Lys Ile Ile Thr Arg Ala Asp Gly Thr
Arg 130 135 140 ctt gaa tac aca gga att aaa agc gat gga tct gga aaa
gct aaa gag 480 Leu Glu Tyr Thr Gly Ile Lys Ser Asp Gly Ser Gly Lys
Ala Lys Glu 145 150 155 160 gtt tta aaa ggc tat act ctt gaa gga act
cta act gct gaa aaa aca 528 Val Leu Lys Gly Tyr Thr Leu Glu Gly Thr
Leu Thr Ala Glu Lys Thr 165 170 175 aca ttg gtg gtt aaa gaa gga act
gtt act tta agc aaa aat att tca 576 Thr Leu Val Val Lys Glu Gly Thr
Val Thr Leu Ser Lys Asn Ile Ser 180 185 190 aaa tct ggg gaa gtt tca
gtt gaa ctt aat gac act gac agt agt gct 624 Lys Ser Gly Glu Val Ser
Val Glu Leu Asn Asp Thr Asp Ser Ser Ala 195 200 205 gct act aaa aaa
act gca gct tgg aat tca ggc act tca act tta aca 672 Ala Thr Lys Lys
Thr Ala Ala Trp Asn Ser Gly Thr Ser Thr Leu Thr 210 215 220 att act
gta aac agt aaa aaa act aaa gac ctt gtg ttt aca aaa gaa 720 Ile Thr
Val Asn Ser Lys Lys Thr Lys Asp Leu Val Phe Thr Lys Glu 225 230 235
240 aac aca att aca gta caa caa tac gac tca aat ggc acc aaa tta gag
768 Asn Thr Ile Thr Val Gln Gln Tyr Asp Ser Asn Gly Thr Lys Leu Glu
245 250 255 ggg tca gca gtt gaa att aca aaa ctt gat gaa att aaa aac
gct tta 816 Gly Ser Ala Val Glu Ile Thr Lys Leu Asp Glu Ile Lys Asn
Ala Leu 260 265 270 aaa taa 822 Lys * 110 273 PRT Artificial
Sequence Altered OspA Protein 110 Met Lys Lys Tyr Leu Leu Gly Ile
Gly Leu Ile Leu Ala Leu Ile Ala 1 5 10 15 Cys Lys Gln Asn Val Ser
Ser Leu Asp Glu Lys Asn Ser Val Ser Val 20 25 30 Asp Leu Pro Gly
Glu Met Lys Val Leu Val Ser Lys Glu Lys Asn Lys 35 40 45 Asp Gly
Lys Tyr Asp Leu Ile Ala Thr Val Asp Lys Leu Glu Leu Lys 50 55 60
Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Val Leu Glu Gly Val Lys 65
70 75 80 Ala Asp Lys Ser Lys Val Lys Leu Thr Ile Ser Asp Asp Leu
Gly Gln 85 90 95 Thr Thr Leu Glu Val Phe Lys Glu Asp Gly Lys Thr
Leu Val Ser Lys 100 105 110 Lys Val Thr Ser Lys Asp Lys Ser Ser Thr
Glu Glu Lys Phe Asn Glu 115 120 125 Lys Gly Glu Val Ser Glu Lys Ile
Ile Thr Arg Ala Asp Gly Thr Arg 130 135 140 Leu Glu Tyr Thr Gly Ile
Lys Ser Asp Gly Ser Gly Lys Ala Lys Glu 145 150 155 160 Val Leu Lys
Gly Tyr Thr Leu Glu Gly Thr Leu Thr Ala Glu Lys Thr 165 170 175 Thr
Leu Val Val Lys Glu Gly Thr Val Thr Leu Ser Lys Asn Ile Ser 180 185
190 Lys Ser Gly Glu Val Ser Val Glu Leu Asn Asp Thr Asp Ser Ser Ala
195 200 205 Ala Thr Lys Lys Thr Ala Ala Trp Asn Ser Gly Thr Ser Thr
Leu Thr 210 215 220 Ile Thr Val Asn Ser Lys Lys Thr Lys Asp Leu Val
Phe Thr Lys Glu 225 230 235 240 Asn Thr Ile Thr Val Gln Gln Tyr Asp
Ser Asn Gly Thr Lys Leu Glu 245 250 255 Gly Ser Ala Val Glu Ile Thr
Lys Leu Asp Glu Ile Lys Asn Ala Leu 260 265 270 Lys 111 822 DNA
Artificial Sequence Altered OspA Nucleic Acid 111 atg aaa aaa tat
tta ttg gga ata ggt cta ata tta gcc tta ata gca 48 Met Lys Lys Tyr
Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile Ala 1 5 10 15 tgt aag
caa aat gtt agc agc ctt gac gag aaa aac agc gtt tca gta 96 Cys Lys
Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val Ser Val 20 25 30
gat ttg cct ggt gaa atg aaa gtt ctt gta agc aaa gaa aaa aac aaa 144
Asp Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys Asn Lys 35
40 45 gac ggc aag tac gat cta att gca aca gta gac aag ctt gag ctt
aaa 192 Asp Gly Lys Tyr Asp Leu Ile Ala Thr Val Asp Lys Leu Glu Leu
Lys 50 55 60 gga act tct gat aaa aac aat gga tct gga gta ctt gaa
ggc gta aaa 240 Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Val Leu Glu
Gly Val Lys 65 70 75 80 gct gac aaa agt aaa gta aaa tta aca att tct
gac gat cta ggt caa 288 Ala Asp Lys Ser Lys Val Lys Leu Thr Ile Ser
Asp Asp Leu Gly Gln 85 90 95 acc aca ctt gaa gtt ttc aaa gaa gat
ggc aaa aca cta gta tca aaa 336 Thr Thr Leu Glu Val Phe Lys Glu Asp
Gly Lys Thr Leu Val Ser Lys 100 105 110 aaa gta act tcc aaa gac aag
tca tca aca gaa gaa aaa ttc aat gaa 384 Lys Val Thr Ser Lys Asp Lys
Ser Ser Thr Glu Glu Lys Phe Asn Glu 115 120 125 aaa ggt gaa gta tct
gaa aaa ata ata aca aga gca gac gga acc aga 432 Lys Gly Glu Val Ser
Glu Lys Ile Ile Thr Arg Ala Asp Gly Thr Arg 130 135 140 ctt gaa tac
aca gga att aaa agc gat gga tct gga aaa gct aaa gag 480 Leu Glu Tyr
Thr Gly Ile Lys Ser Asp Gly Ser Gly Lys Ala Lys Glu 145 150 155 160
gtt tta aaa ggc tat act ctt gaa gga aag cta act gct gaa aaa aca 528
Val Leu Lys Gly Tyr Thr Leu Glu Gly Lys Leu Thr Ala Glu Lys Thr 165
170 175 aca ttg gtg gtt aaa gaa gga act gtt act tta agc aaa aat att
tca 576 Thr Leu Val Val Lys Glu Gly Thr Val Thr Leu Ser Lys Asn Ile
Ser 180 185 190 aaa tct ggg gaa gtt tca gtt gaa ctt aat gac act gac
agt agt gct 624 Lys Ser Gly Glu Val Ser Val Glu Leu Asn Asp Thr Asp
Ser Ser Ala 195 200 205 gct act aaa aaa act gca gct tgg aat tca ggc
act tca act tta aca 672 Ala Thr Lys Lys Thr Ala Ala Trp Asn Ser Gly
Thr Ser Thr Leu Thr 210 215 220 att act gta aac agt aaa aaa act aaa
gac ctt gtg ttt aca aaa gaa 720 Ile Thr Val Asn Ser Lys Lys Thr Lys
Asp Leu Val Phe Thr Lys Glu 225 230 235 240 aac aca att aca gta caa
caa tac gac tca aat ggc acc aaa tta gag 768 Asn Thr Ile Thr Val Gln
Gln Tyr Asp Ser Asn Gly Thr Lys Leu Glu 245 250 255 ggg tca gca gtt
gaa att aca aaa ctt gat gaa att aaa aac gct tta 816 Gly Ser Ala Val
Glu Ile Thr Lys Leu Asp Glu Ile Lys Asn Ala Leu 260 265 270 aaa taa
822 Lys * 112 273 PRT Artificial Sequence Altered OspA Protein 112
Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile Ala 1 5
10 15 Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val Ser
Val 20 25 30 Asp Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys Glu
Lys Asn Lys 35 40 45 Asp Gly Lys Tyr Asp Leu Ile Ala Thr Val Asp
Lys Leu Glu Leu Lys 50 55 60 Gly Thr Ser Asp Lys Asn Asn Gly Ser
Gly Val Leu Glu Gly Val Lys 65 70 75 80 Ala Asp Lys Ser Lys Val Lys
Leu Thr Ile Ser Asp Asp Leu Gly Gln 85 90 95 Thr Thr Leu Glu Val
Phe Lys Glu Asp Gly Lys Thr Leu Val Ser Lys 100 105 110 Lys Val Thr
Ser Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn Glu 115 120 125 Lys
Gly Glu Val Ser Glu Lys Ile Ile Thr Arg Ala Asp Gly Thr Arg 130 135
140 Leu Glu Tyr Thr Gly Ile Lys Ser Asp Gly Ser Gly Lys Ala Lys Glu
145 150 155 160 Val Leu Lys Gly Tyr Thr Leu Glu Gly Lys Leu Thr Ala
Glu Lys Thr 165 170 175 Thr Leu Val Val Lys Glu Gly Thr Val Thr Leu
Ser Lys Asn Ile Ser 180 185 190 Lys Ser Gly Glu Val Ser Val Glu Leu
Asn Asp Thr Asp Ser Ser Ala 195 200 205 Ala Thr Lys Lys Thr Ala Ala
Trp Asn Ser Gly Thr Ser Thr Leu Thr 210 215 220 Ile Thr Val Asn Ser
Lys Lys Thr Lys Asp Leu Val Phe Thr Lys Glu 225 230 235 240 Asn Thr
Ile Thr Val Gln Gln Tyr Asp Ser Asn Gly Thr Lys Leu Glu 245 250 255
Gly Ser Ala Val Glu Ile Thr Lys Leu Asp Glu Ile Lys Asn Ala Leu 260
265 270 Lys 113 822 DNA Artificial Sequence Altered OspA Nucleic
Acid 113 atg aaa aaa tat tta ttg gga ata ggt cta ata tta gcc tta
ata gca 48 Met Lys Lys Tyr Leu Leu Gly Ile
Gly Leu Ile Leu Ala Leu Ile Ala 1 5 10 15 tgt aag caa aat gtt agc
agc ctt gac gag aaa aac agc gtt tca gta 96 Cys Lys Gln Asn Val Ser
Ser Leu Asp Glu Lys Asn Ser Val Ser Val 20 25 30 gat ttg cct ggt
gaa atg aaa gtt ctt gta agc aaa gaa aaa aac aaa 144 Asp Leu Pro Gly
Glu Met Lys Val Leu Val Ser Lys Glu Lys Asn Lys 35 40 45 gac ggc
aag tac gat cta att gca aca gta gac aag ctt gag ctt aaa 192 Asp Gly
Lys Tyr Asp Leu Ile Ala Thr Val Asp Lys Leu Glu Leu Lys 50 55 60
gga act tct gat aaa aac aat gga tct gga gta ctt gaa ggc gta aaa 240
Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Val Leu Glu Gly Val Lys 65
70 75 80 gct gac aaa agt aaa gta aaa tta aca att tct gac gat cta
ggt caa 288 Ala Asp Lys Ser Lys Val Lys Leu Thr Ile Ser Asp Asp Leu
Gly Gln 85 90 95 acc aca ctt gaa gtt ttc aaa gaa gat ggc aaa aca
cta gta tca aaa 336 Thr Thr Leu Glu Val Phe Lys Glu Asp Gly Lys Thr
Leu Val Ser Lys 100 105 110 aaa gta act tcc aaa gac aag tca tca aca
gaa gaa aaa ttc aat gaa 384 Lys Val Thr Ser Lys Asp Lys Ser Ser Thr
Glu Glu Lys Phe Asn Glu 115 120 125 aaa ggt gaa gta tct gaa aaa ata
ata aca aga gca gac gga acc aga 432 Lys Gly Glu Val Ser Glu Lys Ile
Ile Thr Arg Ala Asp Gly Thr Arg 130 135 140 ctt gaa tac aca gga att
aaa agc gat gga tct gga aaa gct aaa gag 480 Leu Glu Tyr Thr Gly Ile
Lys Ser Asp Gly Ser Gly Lys Ala Lys Glu 145 150 155 160 gtt tta aaa
ggc ttt act ctt gaa gga aag cta act gct gaa aaa aca 528 Val Leu Lys
Gly Phe Thr Leu Glu Gly Lys Leu Thr Ala Glu Lys Thr 165 170 175 aca
ttg gtg gtt aaa gaa gga act gtt act tta agc aaa aat att tca 576 Thr
Leu Val Val Lys Glu Gly Thr Val Thr Leu Ser Lys Asn Ile Ser 180 185
190 aaa tct ggg gaa gtt tca gtt gaa ctt aat gac act gac agt agt gct
624 Lys Ser Gly Glu Val Ser Val Glu Leu Asn Asp Thr Asp Ser Ser Ala
195 200 205 gct act aaa aaa act gca gct tgg aat tca ggc act tca act
tta aca 672 Ala Thr Lys Lys Thr Ala Ala Trp Asn Ser Gly Thr Ser Thr
Leu Thr 210 215 220 att act gta aac agt aaa aaa act aaa gac ctt gtg
ttt aca aaa gaa 720 Ile Thr Val Asn Ser Lys Lys Thr Lys Asp Leu Val
Phe Thr Lys Glu 225 230 235 240 aac aca att aca gta caa caa tac gac
tca aat ggc acc aaa tta gag 768 Asn Thr Ile Thr Val Gln Gln Tyr Asp
Ser Asn Gly Thr Lys Leu Glu 245 250 255 ggg tca gca gtt gaa att aca
aaa ctt gat gaa att aaa aac gct tta 816 Gly Ser Ala Val Glu Ile Thr
Lys Leu Asp Glu Ile Lys Asn Ala Leu 260 265 270 aaa taa 822 Lys *
114 273 PRT Artificial Sequence Altered OspA protein 114 Met Lys
Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile Ala 1 5 10 15
Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val Ser Val 20
25 30 Asp Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys Glu Lys Asn
Lys 35 40 45 Asp Gly Lys Tyr Asp Leu Ile Ala Thr Val Asp Lys Leu
Glu Leu Lys 50 55 60 Gly Thr Ser Asp Lys Asn Asn Gly Ser Gly Val
Leu Glu Gly Val Lys 65 70 75 80 Ala Asp Lys Ser Lys Val Lys Leu Thr
Ile Ser Asp Asp Leu Gly Gln 85 90 95 Thr Thr Leu Glu Val Phe Lys
Glu Asp Gly Lys Thr Leu Val Ser Lys 100 105 110 Lys Val Thr Ser Lys
Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn Glu 115 120 125 Lys Gly Glu
Val Ser Glu Lys Ile Ile Thr Arg Ala Asp Gly Thr Arg 130 135 140 Leu
Glu Tyr Thr Gly Ile Lys Ser Asp Gly Ser Gly Lys Ala Lys Glu 145 150
155 160 Val Leu Lys Gly Phe Thr Leu Glu Gly Lys Leu Thr Ala Glu Lys
Thr 165 170 175 Thr Leu Val Val Lys Glu Gly Thr Val Thr Leu Ser Lys
Asn Ile Ser 180 185 190 Lys Ser Gly Glu Val Ser Val Glu Leu Asn Asp
Thr Asp Ser Ser Ala 195 200 205 Ala Thr Lys Lys Thr Ala Ala Trp Asn
Ser Gly Thr Ser Thr Leu Thr 210 215 220 Ile Thr Val Asn Ser Lys Lys
Thr Lys Asp Leu Val Phe Thr Lys Glu 225 230 235 240 Asn Thr Ile Thr
Val Gln Gln Tyr Asp Ser Asn Gly Thr Lys Leu Glu 245 250 255 Gly Ser
Ala Val Glu Ile Thr Lys Leu Asp Glu Ile Lys Asn Ala Leu 260 265 270
Lys 115 822 DNA Artificial Sequence Altered OspA Nucleic Acid 115
atg aaa aaa tat tta ttg gga ata ggt cta ata tta gcc tta ata gca 48
Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala Leu Ile Ala 1 5
10 15 tgt aag caa aat gtt agc agc ctt gac gag aaa aac agc gtt tca
gta 96 Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys Asn Ser Val Ser
Val 20 25 30 gat ttg cct ggt gaa atg aaa gtt ctt gta agc aaa gaa
aaa aac aaa 144 Asp Leu Pro Gly Glu Met Lys Val Leu Val Ser Lys Glu
Lys Asn Lys 35 40 45 gac ggc aag tac gat cta att gca aca gta gac
aag ctt gag ctt aaa 192 Asp Gly Lys Tyr Asp Leu Ile Ala Thr Val Asp
Lys Leu Glu Leu Lys 50 55 60 gga act tct gat aaa aac aat gga tct
gga gta ctt gaa ggc gta aaa 240 Gly Thr Ser Asp Lys Asn Asn Gly Ser
Gly Val Leu Glu Gly Val Lys 65 70 75 80 gct gac aaa agt aaa gta aaa
tta aca att tct gac gat cta ggt caa 288 Ala Asp Lys Ser Lys Val Lys
Leu Thr Ile Ser Asp Asp Leu Gly Gln 85 90 95 acc aca ctt gaa gtt
ttc aaa gaa gat ggc aaa aca cta gta tca aaa 336 Thr Thr Leu Glu Val
Phe Lys Glu Asp Gly Lys Thr Leu Val Ser Lys 100 105 110 aaa gta act
tcc aaa gac aag tca tca aca gaa gaa aaa ttc aat gaa 384 Lys Val Thr
Ser Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn Glu 115 120 125 aaa
ggt gaa gta tct gaa aaa ata ata aca atg gca gac gga acc aga 432 Lys
Gly Glu Val Ser Glu Lys Ile Ile Thr Met Ala Asp Gly Thr Arg 130 135
140 ctt gaa tac aca gga att aaa agc gat gga tct gga aaa gct aaa tat
480 Leu Glu Tyr Thr Gly Ile Lys Ser Asp Gly Ser Gly Lys Ala Lys Tyr
145 150 155 160 gtt tta aaa ggc ttt act ctt gaa gga aag cta act gct
gaa aaa aca 528 Val Leu Lys Gly Phe Thr Leu Glu Gly Lys Leu Thr Ala
Glu Lys Thr 165 170 175 aca ttg gtg gtt aaa gaa gga act gtt act tta
agc atg aat att tca 576 Thr Leu Val Val Lys Glu Gly Thr Val Thr Leu
Ser Met Asn Ile Ser 180 185 190 aaa tct ggg gaa gtt tca gtt gaa ctt
aat gac act gac agt agt gct 624 Lys Ser Gly Glu Val Ser Val Glu Leu
Asn Asp Thr Asp Ser Ser Ala 195 200 205 gct act aaa aaa act gca gct
tgg aat tca ggc act tca act tta aca 672 Ala Thr Lys Lys Thr Ala Ala
Trp Asn Ser Gly Thr Ser Thr Leu Thr 210 215 220 att act gta aac agt
aaa aaa act aaa gac ctt gtg ttt aca aaa gaa 720 Ile Thr Val Asn Ser
Lys Lys Thr Lys Asp Leu Val Phe Thr Lys Glu 225 230 235 240 aac aca
att aca gta caa caa tac gac tca aat ggc acc aaa tta gag 768 Asn Thr
Ile Thr Val Gln Gln Tyr Asp Ser Asn Gly Thr Lys Leu Glu 245 250 255
ggg tca gca gtt gaa att aca aaa ctt gat gaa att aaa aac gct tta 816
Gly Ser Ala Val Glu Ile Thr Lys Leu Asp Glu Ile Lys Asn Ala Leu 260
265 270 aaa taa 822 Lys * 116 273 PRT Artificial Sequence Altered
OspA protein 116 Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu
Ala Leu Ile Ala 1 5 10 15 Cys Lys Gln Asn Val Ser Ser Leu Asp Glu
Lys Asn Ser Val Ser Val 20 25 30 Asp Leu Pro Gly Glu Met Lys Val
Leu Val Ser Lys Glu Lys Asn Lys 35 40 45 Asp Gly Lys Tyr Asp Leu
Ile Ala Thr Val Asp Lys Leu Glu Leu Lys 50 55 60 Gly Thr Ser Asp
Lys Asn Asn Gly Ser Gly Val Leu Glu Gly Val Lys 65 70 75 80 Ala Asp
Lys Ser Lys Val Lys Leu Thr Ile Ser Asp Asp Leu Gly Gln 85 90 95
Thr Thr Leu Glu Val Phe Lys Glu Asp Gly Lys Thr Leu Val Ser Lys 100
105 110 Lys Val Thr Ser Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn
Glu 115 120 125 Lys Gly Glu Val Ser Glu Lys Ile Ile Thr Met Ala Asp
Gly Thr Arg 130 135 140 Leu Glu Tyr Thr Gly Ile Lys Ser Asp Gly Ser
Gly Lys Ala Lys Tyr 145 150 155 160 Val Leu Lys Gly Phe Thr Leu Glu
Gly Lys Leu Thr Ala Glu Lys Thr 165 170 175 Thr Leu Val Val Lys Glu
Gly Thr Val Thr Leu Ser Met Asn Ile Ser 180 185 190 Lys Ser Gly Glu
Val Ser Val Glu Leu Asn Asp Thr Asp Ser Ser Ala 195 200 205 Ala Thr
Lys Lys Thr Ala Ala Trp Asn Ser Gly Thr Ser Thr Leu Thr 210 215 220
Ile Thr Val Asn Ser Lys Lys Thr Lys Asp Leu Val Phe Thr Lys Glu 225
230 235 240 Asn Thr Ile Thr Val Gln Gln Tyr Asp Ser Asn Gly Thr Lys
Leu Glu 245 250 255 Gly Ser Ala Val Glu Ile Thr Lys Leu Asp Glu Ile
Lys Asn Ala Leu 260 265 270 Lys 117 30 DNA Artificial Sequence
Oligonucleotide Primer 117 gaaaaaataa taacaatggc agacggaacc 30 118
30 DNA Artificial Sequence Oligonucleotide Primer 118 ggttccgtct
gccattgtta ttattttttc 30 119 27 DNA Artificial Sequence
Oligonucleotide Primer 119 ggaaaagcta aatatgtttt aaaaggc 27 120 27
DNA Artificial Sequence Oligonucleotide Primer 120 gccttttaaa
acatatttag cttttcc 27 121 29 DNA Artificial Sequence
Oligonucleotide Primer 121 gttactttaa gcatgaatat ttcaaaatc 29 122
29 DNA Artificial Sequence Oligonucleotide Primer 122 gattttgaaa
tattcatgct taaagtaac 29 123 34 DNA Artificial Sequence
Oligonucleotide Primer 123 gaggttttaa aaggctttac tcttgaagga actc 34
124 34 DNA Artificial Sequence Oligonucleotide Primer 124
gagttccttc aagagtaaag ccttttaaaa cctg 34 125 23 DNA Artificial
Sequence Oligonucleotide Primer 125 tcttgaagga aagctaactg ctg 23
126 23 DNA Artificial Sequence Oligonucleotide Primer 126
cagcagttag ctttccttca aga 23 127 819 DNA Borrelia burgdorferi CDS
(1)...(819) 127 atg aaa aaa tat tta ttg gga ata ggt cta ata tta gcc
tta ata gca 48 Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala
Leu Ile Ala 1 5 10 15 tgt aag caa aat gtt agc agc ctt gac gag aaa
aac agc gtt tca gta 96 Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys
Asn Ser Val Ser Val 20 25 30 gat ttg cct ggt gaa atg aaa gtt ctt
gta agc aaa gaa aaa aac aaa 144 Asp Leu Pro Gly Glu Met Lys Val Leu
Val Ser Lys Glu Lys Asn Lys 35 40 45 gac ggc aag tac gat cta att
gca aca gta gac aag ctt gag ctt aaa 192 Asp Gly Lys Tyr Asp Leu Ile
Ala Thr Val Asp Lys Leu Glu Leu Lys 50 55 60 gga act tct gat aaa
aac aat gga tct gga gta ctt gaa ggc gta aaa 240 Gly Thr Ser Asp Lys
Asn Asn Gly Ser Gly Val Leu Glu Gly Val Lys 65 70 75 80 gct gac aaa
agt aaa gta aaa tta aca att tct gac gat cta ggt caa 288 Ala Asp Lys
Ser Lys Val Lys Leu Thr Ile Ser Asp Asp Leu Gly Gln 85 90 95 acc
aca ctt gaa gtt ttc aaa gaa gat ggc aaa aca cta gta tca aaa 336 Thr
Thr Leu Glu Val Phe Lys Glu Asp Gly Lys Thr Leu Val Ser Lys 100 105
110 aaa gta act tcc aaa gac aag tca tca aca gaa gaa aaa ttc aat gaa
384 Lys Val Thr Ser Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn Glu
115 120 125 aaa ggt gaa gta tct gaa aaa ata ata aca aga gca gac gga
acc aga 432 Lys Gly Glu Val Ser Glu Lys Ile Ile Thr Arg Ala Asp Gly
Thr Arg 130 135 140 ctt gaa tac aca gga att aaa agc gat gga tct gga
aaa gct aaa gag 480 Leu Glu Tyr Thr Gly Ile Lys Ser Asp Gly Ser Gly
Lys Ala Lys Glu 145 150 155 160 gtt tta aaa ggc tat gtt ctt gaa gga
act cta act gct gaa aaa aca 528 Val Leu Lys Gly Tyr Val Leu Glu Gly
Thr Leu Thr Ala Glu Lys Thr 165 170 175 aca ttg gtg gtt aaa gaa gga
act gtt act tta agc aaa aat att tca 576 Thr Leu Val Val Lys Glu Gly
Thr Val Thr Leu Ser Lys Asn Ile Ser 180 185 190 aaa tct ggg gaa gtt
tca gtt gaa ctt aat gac act gac agt agt gct 624 Lys Ser Gly Glu Val
Ser Val Glu Leu Asn Asp Thr Asp Ser Ser Ala 195 200 205 gct act aaa
aaa act gca gct tgg aat gca ggc act tca act tta aca 672 Ala Thr Lys
Lys Thr Ala Ala Trp Asn Ala Gly Thr Ser Thr Leu Thr 210 215 220 att
act gta aac aac aaa aaa act aaa gcc ctt gta ttt aca aaa caa 720 Ile
Thr Val Asn Asn Lys Lys Thr Lys Ala Leu Val Phe Thr Lys Gln 225 230
235 240 gac aca att aca tca caa aaa tac gac tca gca gga acc aac ttg
gaa 768 Asp Thr Ile Thr Ser Gln Lys Tyr Asp Ser Ala Gly Thr Asn Leu
Glu 245 250 255 ggc aca gca gtc gaa att aaa aca ctt gat gaa ctt aaa
aac gct tta 816 Gly Thr Ala Val Glu Ile Lys Thr Leu Asp Glu Leu Lys
Asn Ala Leu 260 265 270 aga 819 Arg 128 273 PRT Borrelia
burgdorferi 128 Met Lys Lys Tyr Leu Leu Gly Ile Gly Leu Ile Leu Ala
Leu Ile Ala 1 5 10 15 Cys Lys Gln Asn Val Ser Ser Leu Asp Glu Lys
Asn Ser Val Ser Val 20 25 30 Asp Leu Pro Gly Glu Met Lys Val Leu
Val Ser Lys Glu Lys Asn Lys 35 40 45 Asp Gly Lys Tyr Asp Leu Ile
Ala Thr Val Asp Lys Leu Glu Leu Lys 50 55 60 Gly Thr Ser Asp Lys
Asn Asn Gly Ser Gly Val Leu Glu Gly Val Lys 65 70 75 80 Ala Asp Lys
Ser Lys Val Lys Leu Thr Ile Ser Asp Asp Leu Gly Gln 85 90 95 Thr
Thr Leu Glu Val Phe Lys Glu Asp Gly Lys Thr Leu Val Ser Lys 100 105
110 Lys Val Thr Ser Lys Asp Lys Ser Ser Thr Glu Glu Lys Phe Asn Glu
115 120 125 Lys Gly Glu Val Ser Glu Lys Ile Ile Thr Arg Ala Asp Gly
Thr Arg 130 135 140 Leu Glu Tyr Thr Gly Ile Lys Ser Asp Gly Ser Gly
Lys Ala Lys Glu 145 150 155 160 Val Leu Lys Gly Tyr Val Leu Glu Gly
Thr Leu Thr Ala Glu Lys Thr 165 170 175 Thr Leu Val Val Lys Glu Gly
Thr Val Thr Leu Ser Lys Asn Ile Ser 180 185 190 Lys Ser Gly Glu Val
Ser Val Glu Leu Asn Asp Thr Asp Ser Ser Ala 195 200 205 Ala Thr Lys
Lys Thr Ala Ala Trp Asn Ala Gly Thr Ser Thr Leu Thr 210 215 220 Ile
Thr Val Asn Asn Lys Lys Thr Lys Ala Leu Val Phe Thr Lys Gln 225 230
235 240 Asp Thr Ile Thr Ser Gln Lys Tyr Asp Ser Ala Gly Thr Asn Leu
Glu 245 250 255 Gly Thr Ala Val Glu Ile Lys Thr Leu Asp Glu Leu Lys
Asn Ala Leu 260 265 270 Arg 129 9 PRT Artificial Sequence Residue
165-173 of B31 OspA 129 Tyr Val Leu Glu Gly Thr Leu Thr Ala 1 5 130
9 PRT Artificial Sequence Residue 332-340 of hLFA-1 130 Tyr Val Ile
Glu Gly Thr Ser Lys Gln 1 5
uspto.report is an independent third-party trademark research tool that is not affiliated, endorsed, or sponsored by the United States Patent and Trademark Office (USPTO) or any other governmental organization. The information provided by uspto.report is based on publicly available data at the time of writing and is intended for informational purposes only.
While we strive to provide accurate and up-to-date information, we do not guarantee the accuracy, completeness, reliability, or suitability of the information displayed on this site. The use of this site is at your own risk. Any reliance you place on such information is therefore strictly at your own risk.
All official trademark data, including owner information, should be verified by visiting the official USPTO website at www.uspto.gov. This site is not intended to replace professional legal advice and should not be used as a substitute for consulting with a legal professional who is knowledgeable about trademark law.