U.S. patent application number 10/414062 was filed with the patent office on 2003-11-06 for bis-arylsulfones.
This patent application is currently assigned to Pharmacia & Upjohn Company. Invention is credited to Jacobsen, Eric Jon, King, Stephen J..
Application Number | 20030207866 10/414062 |
Document ID | / |
Family ID | 27498914 |
Filed Date | 2003-11-06 |
United States Patent
Application |
20030207866 |
Kind Code |
A1 |
Jacobsen, Eric Jon ; et
al. |
November 6, 2003 |
Bis-arylsulfones
Abstract
The present invention provides pharmaceutically active compounds
useful for the treatment of diseases or disorders of the central
nervous system.
Inventors: |
Jacobsen, Eric Jon;
(Richland, MI) ; King, Stephen J.; (Portage,
MI) |
Correspondence
Address: |
Pharmacia & Upjohn Company
Global Intellectual Property
301 Henrietta Street
Kalamazoo
MI
49001
US
|
Assignee: |
Pharmacia & Upjohn
Company
|
Family ID: |
27498914 |
Appl. No.: |
10/414062 |
Filed: |
April 15, 2003 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
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10414062 |
Apr 15, 2003 |
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09877308 |
Jun 8, 2001 |
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6579870 |
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60212894 |
Jun 20, 2000 |
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60237025 |
Sep 29, 2000 |
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60239713 |
Oct 12, 2000 |
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60268261 |
Feb 13, 2001 |
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Current U.S.
Class: |
514/218 ;
540/575 |
Current CPC
Class: |
A61P 25/22 20180101;
A61P 15/08 20180101; A61P 1/04 20180101; A61P 37/04 20180101; A61P
1/08 20180101; A61P 3/04 20180101; A61P 25/18 20180101; A61P 43/00
20180101; A61P 25/20 20180101; A61P 25/24 20180101; C07D 243/08
20130101; A61P 25/12 20180101; C07D 295/135 20130101; A61P 25/00
20180101; A61P 25/28 20180101; A61P 25/32 20180101; A61P 25/06
20180101; A61P 25/14 20180101; A61P 9/12 20180101 |
Class at
Publication: |
514/218 ;
540/575 |
International
Class: |
A61K 031/551; C07D
243/08 |
Claims
What is claimed is:
1. A compound of formula I 25or a pharmaceutically acceptable salt
thereof wherein R.sup.1 is a) H, b) C.sub.1-12 alkyl, c)
C.sub.1-6alkylaryl, or d) aryl; at each occurrence, R.sup.2 is
independently a) H, b) C.sub.1-12 alkyl, c) C.sub.1-12 alkenyl, d)
halo, e) NO.sub.2, f) CN, g) CF.sub.3, or h) OR.sup.1, at each
occurrence, R.sup.3 is independently a) H, b) C.sub.1-12 alkyl, c)
C.sub.1-12 alkenyl, or d) R.sup.4; R.sup.4 is a) halo, b) NO.sub.2,
c) CN, d) CF.sub.3, e) OR.sup.1, f) CONR.sup.1R.sup.1, g)
NHSO.sub.2R.sup.1, h) NR.sup.1R.sup.1, i) NR.sup.1COR.sup.1, j)
SO.sub.2NR.sup.1R.sup.1, k) C(.dbd.O)R.sup.1, l) CO.sub.2R.sup.1,
or m) S(O).sub.iR.sup.1; at each occurrence, R.sup.5 is
independently a) H, b) C.sub.1-6 alkyl, c) C.sub.1-12 alkylaryl, d)
aryl, e) C(.dbd.O)R.sup.1, f) S(O).sub.2R.sup.1, g)
C(O)NR.sup.1R.sup.1, h) CO.sub.2R.sup.1, or i) CSR.sup.1; at each
occurrence, alkyl, alkenyl, alkyaryl or aryl is optionally
substituted with one or more R.sup.4; i is 0, 1, or 2; m is 1, 2 or
3; and n is 1, 2, 3, 4, or 5.
2. A compound of claim 1 wherein R.sup.1 is hydrogen or
C.sub.1-4alkyl.
3. A compound of claim 2 wherein R.sup.2 is H.
4. A compound of claim 2 wherein R.sup.5 is H.
5. A compound of claim 2 wherein one of the R.sup.5 is H, the other
one is C.sub.1-4alkyl.
6. A compound of claim 2 wherein one of the R.sup.5 is H, the other
one is C(.dbd.O)CH.sub.3.
7. A compound of claim 4, 5 or 6 wherein R.sup.3 is hydrogen.
8. A compound of claim 4, 5 or 6 wherein R.sup.3 is fluoro; and n
is 1 or 2.
9. A compound of claim 4, 5 or 6 wherein R.sup.3 is
C.sub.1-4alkyl.
10. A compound of claim 9 wherein R.sup.1 is hydrogen.
11. A compound of formula II 26or a pharmaceutically acceptable
salt thereof wherein R.sup.6 is H, or C.sub.1-4 alkyl; R.sup.7 is
H, halo, C.sub.1-4 alkyl, or NR.sup.6R.sup.6; R.sup.8 is H, halo,
or C.sub.1-4 alkyl; R.sup.9 is H, C.sub.1-4 alkyl,
C(.dbd.O)R.sup.10, S(O).sub.2R.sup.10, C(O)NR.sup.10OR.sup.10,
CO.sub.2R.sup.10, or CSR.sup.10; and R.sup.10 is H, C.sub.1-12
alkyl, C.sub.1-6 alkylaryl, or aryl.
12. A compound of claim 11 wherein R.sup.6 is hydrogen.
13. A compound of claim 11 wherein R.sup.6 is methyl, or ethyl.
14. A compound of claim 12 or 13 wherein R.sup.8 is hydrogen.
15. A compound of claim 12 or 13 wherein R.sup.8 is fluoro.
16. A compound of claim 12 or 13 wherein R.sup.8 is methyl.
17. A compound of claim 12 or 13 wherein each R.sup.9 is
independently hydrogen, methyl or ethyl.
18. A method for treating a disease or disorder of the central
nervous system in a mammal comprising administering a
therapeutically effective amount of a compound of formula III, or a
pharmaceutically acceptable salt thereof, to said mammal 27wherein
R.sup.1 is a) H, b) C.sub.1-12 alkyl, c) C.sub.1-6 alkylaryl, or d)
aryl; at each occurrence, R.sup.2 is independently a) H, b)
C.sub.1-12 alkyl, c) C.sub.1-12 alkenyl, d) halo, e) NO.sub.2, f)
CN, g) CF.sub.3, or h) OR.sup.1, at each occurrence, R.sup.3 is
independently a) H, b) C.sub.1-12 alkyl, c) C.sub.1-12 alkenyl, or
d) R.sup.4; R.sup.4 is a) halo, b) NO.sub.2, c) CN, d) CF.sub.3, e)
OR.sup.1, f) CONR.sup.1R.sup.1, g) NHSO.sub.2R.sup.1, h)
NR.sup.1R.sup.1, i) NR.sup.1COR.sup.1, j) SO.sub.2NR.sup.1R.sup.1,
k) C(.dbd.O)R.sup.1, l) CO.sub.2R.sup.1, or m) S(O).sub.iR.sup.1;
at each occurrence, R.sup.5 is independently a) H, b) C.sub.1-6
alkyl, c) C.sub.1-12 alkylaryl, d) aryl, e) C(.dbd.O)R.sup.1, f)
S(O).sub.2R.sup.1, g) C(O)NR.sup.1R.sup.1, h) CO.sub.2R.sup.1, or
i) CSR.sup.1; at each occurrence, alkyl, alkenyl, alkyaryl or aryl
is optionally substituted with one or more R.sup.4; k is 1 or 2; i
is 0, 1, or 2; m is 1, 2 or 3; and n is 1, 2, 3, 4, or 5.
19. A method of claim 18 wherein R.sup.1 is H or C.sub.1-4 alkyl;
R.sup.2 is H, halo or C.sub.1-4 alkyl, R.sup.5 is H, C.sub.1-4
alkyl or COC.sub.1-4alkyl; and R.sup.3 is H, halo, or C.sub.1-4
alkyl.
20. A method for treating a disease or disorder in a mammal wherein
the 5-HT receptor is implicated and modulation of 5-HT function is
desired comprising administering a therapeutically effective amount
of a compound of formula III as shown in claim 18, or a
pharmaceutically acceptable salt thereof wherein, to said
mammal.
21. The method of claim 20 wherein the receptor is a 5-HT.sub.6
receptor.
22. The method of claim 18 or 20 wherein the mammal is a human.
23. The method of claim 18 or 20 wherein said disease or disorder
is anxiety, depression, schizophrenia, a stress related disease,
panic disorder, a phobia, obsessive compulsive disorder,
post-traumatic-stress syndrome, immune system depression, major
depression, psychosis, paraphrenia, mania, convulsive disorders,
personality disorders, migraine headache, drug addiction,
alcoholism, obesity, eating disorders, or sleep disorders.
24. The method of claim 18 or 20 wherein the disease or disorder is
psychotic, affective, vegetative, and psychomotor symptoms of
schizophrenia and the extrapyramidal motor side effects of other
antipsychotic drugs.
25. The method of claim 18 or 20 wherein the disease is anxiety, or
a stress related disease.
26. The method of claim 18 or 20 wherein the disease is
obesity.
27. The method of claim 18 or 20 wherein the disease is
depression.
28. The method of claim 18 or 20 wherein said disease or disorder
is obesity, depression, schizophrenia, schizophreniform disorder,
schizoaffective disorder, delusional disorder, a stress related
disease (e.g. general anxiety disorder), panic disorder, a phobia,
obsessive compulsive disorder, post-traumatic-stress syndrome,
immune system depression, major depression, a stress induced
problem with the urinary, gastrointestinal or cardiovascular system
(e.g., stress incontinence), neurodegenerative disorders, autism,
chemotherapy-induced vomiting, hypertension, migraine headaches,
cluster headaches, sexual dysfunction in a mammal (e.g. a human),
addictive disorder and withdrawal syndrome, an adjustment disorder,
an age-associated learning and mental disorder, anorexia nervosa,
apathy, an attention-deficit disorder due to general medical
conditions, attention-deficit hyperactivity disorder, behavioral
disturbance (including agitation in conditions associated with
diminished cognition (e.g., dementia, mental retardation or
delirium)), bipolar disorder, bulimia nervosa, chronic fatigue
syndrome, conduct disorder, cyclothymic disorder, dysthymic
disorder, fibromyalgia and other somatoform disorders, generalized
anxiety disorder, an inhalation disorder, an intoxication disorder,
movement disorder (e.g., Huntington's disease or Tardive
Dyskinesia), oppositional defiant disorder, peripheral neuropathy,
post-traumatic stress disorder, premenstrual dysphoric disorder, a
psychotic disorder (brief and long duration disorders, psychotic
disorder due to medical condition, psychotic disorder NOS), mood
disorder (major depressive or bipolar disorder with psychotic
features) seasonal affective disorder, a sleep disorder, cognitive
disorders, irritable bowel syndrome, a specific developmental
disorder, agitation disorder, selective serotonin reuptake
inhibition (SSRI) "poop out" syndrome or Tourette's syndrome.
29. The method of claim 18 or 20 wherein said compound is
administered rectally, topically, nasally, sublingually,
transdermally or parenterally.
30. The method of claim 18 or 20 wherein said compound is
administered orally.
31. The method of claim 18 or 20 wherein said compound is
administered in an amount from about 0.01 to about 300 mg/kg of
body weight of said mammal per day.
32. The method of claim 31 wherein said compound is administered in
an amount from about 0.1 to about 50 mg/kg of body weight of said
mammal per day.
33. The method of claim 31 wherein said compound is administered in
an amount from about 1 to about 30 mg/kg of body weight of said
mammal per day.
34. A compound of claim 1 which is (1)
5-(1,4-diazepan-1-yl)-2-[(3-fluorop- henyl)sulfonyl]phenylamine,
(2) 5-(1,4-diazepan-1-yl)-2-[(3,4-difluorophen-
yl)sulfonyl]phenylamine, (3)
5-(1,4-diazepan-1-yl)-2-(phenylsulfonyl)pheny- lamine, (4)
5-(1,4-diazepan-1-yl)-2-[(3,5-difluorophenyl)sulfonyl]phenylam-
ine, (5)
5-(1,4-diazepan-1-yl)-2-[(3-fluorophenyl)sulfonyl]-N-methylphenyl-
amine, (6)
5-(1,4-diazepan-1-yl)-N-ethyl-2-[(3-fluorophenyl)sulfonyl]anili-
ne, (7)
5-(1,4-diazepan-1-yl)-N,N-diethyl-2-[(3-fluorophenyl)sulfonyl]phen-
ylamine, (8) N-[5-(1,4-diazepan-1-yl)-2-(phenylsulfonyl)
phenyl]acetamide, (9)
N-[2-[(3-fluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-yl)phenyl]-
acetamide, or (10) N-[5-(1,4-diazepan-1-yl)-2-[(3-fluorophenyl)
sulfonyl]phenyl]-N-ethylacetamide.
35. A compound of claim 11 which is (1)
2-(phenylsulfonyl)-5-(1-piperaziny- l)phenylamine, (2)
2-[(4-fluorophenyl)sulfonyl]-5-(1-piperazinyl)phenylami- ne, (3)
2-[(4-fluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)phenylamine-
, (4) 2-[(4-methylphenyl)sulfonyl]-5-(1-piperazinyl)phenylamine,
(5)
2-[(4-methylphenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)phenylamine,
(6) 5-(4-methyl-1-piperazinyl)-2-(phenylsulfonyl)phenylamine, (7)
2-[(3-fluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)phenylamine,
or (8) N-ethyl-2-(phenylsulfonyl)-5-(1-piperazinyl)phenylamine.
36. A compound selected from
N-[5-(1,4-diazepan-1-yl)-2-[(3-fluorophenyl)s-
ulfonyl]phenyl]acetamide, or its pharmaceutically acceptable salt
thereof.
37. A compound selected from
5-(1,4-diazepan-1-yl)-2-(phenylsulfonyl)pheny- lamine, or its
pharmaceutically acceptable salt thereof.
38. A compound selected from
N-[5-(1,4-diazepan-1-yl)-2-(phenylsulfonyl) phenyl]acetamide, or
its pharmaceutically acceptable salt thereof.
39. A compound selected from: (1)
5-(1,4-diazepan-1-yl)-2-[(4-fluorophenyl- )sulfonyl]phenylamine,
(2) 5-(1,4-diazepan-1-yl)-N-methyl-2-(phenylsulfony- l)phenylamine,
(3) 5-(1,4-diazepan-1-yl)-2-[(4-fluorophenyl)sulfonyl]-N-me-
thylphenylamine, (4)
5-(1,4-diazepan-1-yl)-2-[(3,4-difluorophenyl)sulfonyl-
]-N-methylphenylamine, (5)
5-(1,4-diazepan-1-yl)-2-[(3,5-difluorophenyl)su-
lfonyl]-N-methylphenylamine, (6)
5-(1,4-diazepan-1-yl)-N-ethyl-2-(phenylsu- lfonyl)phenylamine, (7)
5-(1,4-diazepan-1-yl)-N-ethyl-2-[(4-fluorophenyl)s-
ulfonyl]phenylamine, (8)
5-(1,4-diazepan-1-yl)-N-ethyl-2-[(3,4-difluorophe-
nyl)sulfonyl]phenylamine, (9)
5-(1,4-diazepan-1-yl)-N-ethyl-2-[(3,5-difluo-
rophenyl)sulfonyl]phenylamine, (10)
5-(1,4-diazepan-1-yl)-2-(phenylsulfony- l)-N-propylphenylamine,
(11) 5-(1,4-diazepan-1-yl)-2-[(3-fluorophenyl)sulf-
onyl]-N-propylphenylamine, (12)
5-(1,4-diazepan-1-yl)-2-[(4-fluorophenyl)s-
ulfonyl]-N-propylphenylamine, (13)
5-(1,4-diazepan-1-yl)-2-[(3,4-difluorop-
henyl)sulfonyl]-N-propylphenylamine, (14)
5-(1,4-diazepan-1-yl)-2-[(3,5-di-
fluorophenyl)sulfonyl]-N-propylphenylamine, (15)
5-(1,4-diazepan-1-yl)-N,N- -dimethyl-2-(phenylsulfonyl)phenylamine,
(16) 5-(1,4-diazepan-1-yl)-2-[(3--
fluorophenyl)sulfonyl]-N,N-dimethylphenylamine, (17)
5-(1,4-diazepan-1-yl)-2-[(4-fluorophenyl)sulfonyl]-N,N-dimethylphenylamin-
e, (18)
5-(1,4-diazepan-1-yl)-2-[(3,4-difluorophenyl)sulfonyl]-N,N-dimethy-
lphenylamine, (19)
5-(1,4-diazepan-1-yl)-2-[(3,5-difluorophenyl)sulfonyl]--
N,N-dimethylphenylamine, (20)
5-(1,4-diazepan-1-yl)-N,N-diethyl-2-(phenyls- ulfonyl)phenylamine,
(21) 5-(1,4-diazepan-1-yl)-N,N-diethyl-2-[(4-fluoroph-
enyl)sulfonyl]phenylamine, (22)
5-(1,4-diazepan-1-yl)-N,N-diethyl-2-[(3,4--
difluorophenyl)sulfonyl]phenylamine, (23)
5-(1,4-diazepan-1-yl)-N,N-diethy-
l-2-[(3,5-difluorophenyl)sulfonyl]phenyl amine, (24)
5-(1,4-diazepan-1-yl)-2-(phenylsulfonyl)-N,N-dipropylphenylamine,
(25)
5-(1,4-diazepan-1-yl)-2-[(3-fluorophenyl)sulfonyl]-N,N-dipropylphenylamin-
e, (26)
5-(1,4-diazepan-1-yl)-2-[(4-fluorophenyl)sulfonyl]-N,N-dipropylphe-
nylamine, (27)
5-(1,4-diazepan-1-yl)-2-[(3,4-difluorophenyl)sulfonyl]-N,N--
dipropylphenylamine, (28)
5-(1,4-diazepan-1-yl)-2-[(3,5-difluorophenyl)sul-
fonyl]-N,N-dipropylphenylamine, or a pharmaceutically acceptable
salt thereof.
40. A compound selected from a group consisting of: (1)
N-[5-(1,4-diazepan-1-yl)-2-[(4-fluorophenyl)sulfonyl]phenyl]acetamide,
(2)
N-[5-(1,4-diazepan-1-yl)-2-[(3,4-difluorophenyl)sulfonyl]phenyl]aceta-
mide, (3)
N-[5-(1,4-diazepan-1-yl)-2-[(3,5-difluorophenyl)sulfonyl]phenyl]-
acetamide, (4)
N-[5-(1,4-diazepan-1-yl)-2-(phenylsulfonyl)phenyl]-N-methyl-
acetamide, (5)
N-{5-(1,4-diazepan-1-yl)-2-[(3-fluorophenyl)sulfonyl]phenyl-
}-N-methylacetamide, (6)
N-[5-(1,4-diazepan-1-yl)-2-[(4-fluorophenyl)sulfo-
nyl]phenyl]-N-methylacetamide, (7)
N-[5-(1,4-diazepan-1-yl)-2-[(3,4-difluo-
rophenyl)sulfonyl]phenyl]-N-methylacetamide, (8)
N-[5-(1,4-diazepan-1-yl)--
2-[(3,5-difluorophenyl)sulfonyl]phenyl]-N-methylacetamide, (9)
N-[5-(1,4-diazepan-1-yl)-2-(phenylsulfonyl)phenyl]-N-ethyl
acetamide, (10)
N-[5-(1,4-diazepan-1-yl)-2-[(4-fluorophenyl)sulfonyl]phenyl]-N-ethyl-
acetamide, (11)
N-[5-(1,4-diazepan-1-yl)-2-[(3,4-difluorophenyl)sulfonyl]p-
henyl]-N-ethylacetamide, (12)
N-[5-(1,4-diazepan-1-yl)-2-[(3,5-difluorophe-
nyl)sulfonyl]phenyl]-N-ethylacetamide, (13)
N-[5-(1,4-diazepan-1-yl)-2-(ph-
enylsulfonyl)phenyl]-N-propylacetamide, (14)
N-[5-(1,4-diazepan-1-yl)-2-[(-
3-fluorophenyl)sulfonyl]phenyl]-N-propylacetamide, (15)
N-[5-(1,4-diazepan-1-yl)-2-[(4-fluorophenyl)sulfonyl]phenyl]-N-propylacet-
amide, (16)
N-[5-(1,4-diazepan-1-yl)-2-[(3,4-difluorophenyl)sulfonyl]pheny-
l-N-propylacetamide, (17)
N-[5-(1,4-diazepan-1-yl)-2-[(3,5-difluorophenyl)-
sulfonyl]phenyl]-N-propylacetamide, (18)
N-[5-(4-methyl-1,4-diazepan-1-yl)-
-2-(phenylsulfonyl)phenyl]acetamide, (19)
N-[2-[(4-fluorophenyl)sulfonyl]--
5-(4-methyl-1,4-diazepan-1-yl)-phenyl]acetamide, (20)
N-[2-[(3,4-difluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-yl)phenyl]-
acetamide, (21)
N-[2-[(3,5-difluorophenyl)sulfonyl-5-(4-methyl-1,4-diazepa-
n-1-yl)phenyl]acetamide, (22)
N-methyl-N-[5-(4-methyl-1,4-diazepan-1-yl)-2-
-(phenylsulfonyl)phenyl]acetamide, (23)
N-[2-[(3-fluorophenyl)sulfonyl]-5--
(4-methyl-1,4-diazepan-1-yl)phenyl]-N-methylacetamide, (24)
N-[2-[(4-fluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-yl)phenyl]-N-m-
ethylacetamide, (25)
N-[2-[(3,4-difluorophenyl)sulfonyl]-5-(4-methyl-1,4-d-
iazepan-1-yl)phenyl]-N-methylacetamide, (26)
N-[2-[(3,5-difluorophenyl)sul-
fonyl]-5-(4-methyl-1,4-diazepan-1-yl)phenyl]-N-methylacetamide,
(27)
N-ethyl-N-[5-(4-methyl-1,4-diazepan-1-yl)-2-(phenylsulfonyl)phenylacetami-
de, (28)
N-ethyl-N-[2-[(3-fluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan--
1-yl)phenyl]acetamide, (29)
N-ethyl-N-[2-[(4-fluorophenyl)sulfonyl]-5-(4-m-
ethyl-1,4-diazepan-1-yl)phenyl]acetamide, (30)
N-ethyl-N-[2-[(3,4-difluoro-
phenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-yl)phenyl]acetamide,
(31)
N-ethyl-N-[2-[(3,5-difluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-yl-
)phenyl]acetamide, (32)
N-[5-(4-methyl-1,4-diazepan-1-yl)-2-(phenylsulfony-
l)phenyl]-N-propylacetamide, (33)
N-[2-[(3-fluorophenyl)sulfonyl]-5-(4-met-
hyl-1,4-diazepan-1-yl)phenyl]-N-propylacetamide, (34)
N-[2-[(4-fluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-yl)phenyl]-N-p-
ropylacetamide, (35)
N-[2-[(3,4-difluorophenyl)sulfonyl]-5-(4-methyl-1,4-d-
iazepan-1-yl)phenyl]-N-propylacetamide, (36)
N-[2-[(3,5-difluorophenyl)sul-
fonyl]-5-(4-methyl-1,4-diazepan-1-yl)phenyl]-N-propylacetamide, or
a pharmaceutically acceptable salt thereof.
41. A compound selected from a group consisting of: (1)
5-(4-methyl-1,4-diazepan-1-yl)-2-(phenylsulfonyl)phenylamine, (2)
2-[(3-fluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-yl)phenylamine,
(3)
2-[(4-fluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-yl)phenylamin-
e, (4)
2-[(3,4-difluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-yl)phen-
ylamine, (5)
2-[(3,5-difluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-y-
l)phenyl amine, (6)
N-methyl-N-[5-(4-methyl-1,4-diazepan-1-yl)-2-(phenylsu-
lfonyl)phenyl]amine, (7)
N-[2-[(3-fluorophenyl)sulfonyl]-5-(4-methyl-1,4-d-
iazepan-1-yl)phenyl]-N-methylamine, (8)
N-[2-[(4-fluorophenyl)sulfonyl]-5--
(4-methyl-1,4-diazepan-1-yl)phenyl]-N-methylamine, (9)
N-[2-[(3,4-difluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-yl)phenyl]-
-N-methylamine, (10)
N-[2-[(3,5-difluorophenyl)sulfonyl]-5-(4-methyl-1,4-d-
iazepan-1-yl)phenyl]-N-methylamine, (11)
N-ethyl-N-[5-(4-methyl-1,4-diazep-
an-1-yl)-2-(phenylsulfonyl)phenyl]amine, (12)
N-ethyl-N-[2-[(3-fluoropheny-
l)sulfonyl]-5-(4-methyl-1,4-diazepan-1-yl)phenyl]amine, (13)
N-ethyl-N-[2-[(4-fluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-yl)phe-
nyl]amine, (14)
N-ethyl-N-[2-[(3,4-difluorophenyl)sulfonyl]-5-(4-methyl-1,-
4-diazepan-1-yl)phenyl]amine, (15)
N-ethyl-N-[2-[(3,5-difluorophenyl)sulfo-
nyl]-5-(4-methyl-1,4-diazepan-1-yl)phenyl]amine, (16)
N-[5-(4-methyl-1,4-diazepan-1-yl)-2-(phenylsulfonyl)phenyl]-N-propylamine-
, (17)
N-[2-[(3-fluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-yl)pheny-
l]-N-propylamine, (18)
N-[2-[(4-fluorophenyl)sulfonyl]-5-(4-methyl-1,4-dia-
zepan-1-yl)phenyl]-N-propylamine, (19)
N-[2-[(3,4-difluorophenyl)sulfonyl]-
-5-(4-methyl-1,4-diazepan-1-yl)phenyl]-N-propylamine, (20)
N-[2-[(3,5-difluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-yl)phenyl]-
-N-propylamine, (21)
N,N-dimethyl-N-[5-(4-methyl-1,4-diazepan-1-yl)-2-(phe-
nylsulfonyl)phenyl]amine, (22)
N-[2-[(3-fluorophenyl)sulfonyl]-5-(4-methyl-
-1,4-diazepan-1-yl)phenyl]-N,N-dimethylamine, (23)
N-[2-[(4-fluorophenyl)s-
ulfonyl]-5-(4-methyl-1,4-diazepan-1-yl)phenyl]-N,N-dimethylamine,
(24)
N-[2-[(3,4-difluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-yl)phenyl]-
-N,N-dimethylamine, (25)
N-[2-[(3,5-difluorophenyl)sulfonyl]-5-(4-methyl-1-
,4-diazepan-1-yl)phenyl]-N,N-dimethylamine, (26)
N,N-diethyl-N-[5-(4-methy-
l-1,4-diazepan-1-yl)-2-(phenylsulfonyl)phenyl]amine, (27)
N,N-diethyl-N-[2-[(3-fluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-yl-
)phenyl]amine, (28)
N,N-diethyl-N-[2-[(4-fluorophenyl)sulfonyl]-5-(4-methy-
l-1,4-diazepan-1-yl)phenyl]amine, (29)
N,N-diethyl-N-[2-[(3,4-difluorophen-
yl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-yl)phenyl]amine, (30)
N,N-diethyl-N-[2-[(3,5-difluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan--
1-yl)phenyl]amine, (31)
N-[5-(4-methyl-1,4-diazepan-1-yl)-2-(phenylsulfony-
l)phenyl]-N,N-dipropylamine, (32)
N-[2-[(3-fluorophenyl)sulfonyl]-5-(4-met-
hyl-1,4-diazepan-1-yl)phenyl]-N,N-dipropylamine, (33)
N-[2-[(4-fluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-yl)phenyl]-N,N-
-dipropylamine, (34)
N-[2-[(3,4-difluorophenyl)sulfonyl]-5-(4-methyl-1,4-d-
iazepan-1-yl)phenyl]-N,N-dipropylamine, or (35)
N-[2-[(3,5-difluorophenyl)-
sulfonyl]-5-(4-methyl-1,4-diazepan-1-yl)phenyl-N,N-dipropylamine,
or a pharmaceutically acceptable salt thereof.
42. A compound selected from a group consisting of: (1)
2-[(3-fluorophenyl)sulfonyl]-5-(1-piperazinyl)phenylamine, (2)
2-[(3,4-difluorophenyl)sulfonyl]-5-(1-piperazinyl)phenylamine, (3)
2-[(3,5-difluorophenyl)sulfonyl]-5-(1-piperazinyl)phenylamine, (4)
N-methyl-2-(phenylsulfonyl)-5-(1-piperazinyl)phenylamine, (5)
2-[(3-fluorophenyl)sulfonyl]-N-methyl-5-(1-piperazinyl)phenylamine,
(6)
2-[(3,4-difluorophenyl)sulfonyl]-N-methyl-5-(1-piperazinyl)phenylamine,
(7)
2-[(3,5-difluorophenyl)sulfonyl]-N-methyl-5-(1-piperazinyl)phenylamin-
e, (8)
N-ethyl-2-[(4-fluorophenyl)sulfonyl]-5-(1-piperazinyl)phenylamine,
(9)
N-ethyl-2-[(3,4-difluorophenyl)sulfonyl]-5-(1-piperazinyl)phenylamine-
, (10)
N-ethyl-2-[(3,5-difluorophenyl)sulfonyl]-5-(1-piperazinyl)phenylami-
ne, (11) 2-(phenylsulfonyl)-5-(1-piperazinyl)-N-propylphenylamine,
(12)
2-[(3-fluorophenyl)sulfonyl]-5-(1-piperazinyl)-N-propylphenylamine,
(13)
2-[(4-fluorophenyl)sulfonyl]-5-(1-piperazinyl)-N-propylphenylamine,
(14)
2-[(3,4-difluorophenyl)sulfonyl]-5-(1-piperazinyl)-N-propylphenylamine,
(15)
2-[(3,5-difluorophenyl)sulfonyl]-5-(1-piperazinyl)-N-propylphenylami-
ne, (16)
N,N-dimethyl-2-(phenylsulfonyl)-5-(1-piperazinyl)phenylamine, (17)
2-[(3-fluorophenyl)sulfonyl]-N,N-dimethyl-5-(1-piperazinyl)phenylami-
ne, (18)
2-[(4-fluorophenyl)sulfonyl]-N,N-dimethyl-5-(1-piperazinyl)phenyl
amine, (19)
2-[(3,4-difluorophenyl)sulfonyl]-N,N-dimethyl-5-(1-piperaziny-
l)phenylamine, (20)
2-[(3,5-difluorophenyl)sulfonyl]-N,N-dimethyl-5-(1-pip-
erazinyl)phenylamine, (21)
N,N-diethyl-2-(phenylsulfonyl)-5-(1-piperazinyl- )phenylamine, (22)
N,N-diethyl-2-[(3-fluorophenyl)sulfonyl]-5-(1-piperazin-
yl)phenylamine, (23)
N,N-diethyl-2-[(4-fluorophenyl)sulfonyl]-5-(1-piperaz-
inyl)phenylamine, (24)
N,N-diethyl-2-[(3,4-difluorophenyl)sulfonyl]-5-(1-p-
iperazinyl)phenylamine, (25)
N,N-diethyl-2-[(3,5-difluorophenyl)sulfonyl]--
5-(1-piperazinyl)phenylamine, (26)
2-(phenylsulfonyl)-5-(1-piperazinyl)-N,- N-dipropylphenylamine,
(27) 2-[(3-fluorophenyl)sulfonyl]-5-(1-piperazinyl)-
-N,N-dipropylphenylamine, (28)
2-[(4-fluorophenyl)sulfonyl]-5-(1-piperazin-
yl)-N,N-dipropylphenylamine, (29)
2-[(3,4-difluorophenyl)sulfonyl]-5-(1-pi-
perazinyl)-N,N-dipropylphenylamine, (30)
2-[(3,5-difluorophenyl)sulfonyl]--
5-(1-piperazinyl)-N,N-dipropylphenylamine, or a pharmaceutically
acceptable salt thereof.
43. A compound selected from a group consisting of: (1)
N-[2-(phenylsulfonyl)-5-(1-piperazinyl)phenyl]acetamide, (2)
N-[2-[(3-fluorophenyl)sulfonyl]-5-(1-piperazinyl)phenyl]acetamide,
(3)
N-[2-[(4-fluorophenyl)sulfonyl]-5-(1-piperazinyl)phenyl]acetamide,
(4)
N-[2-[(3,4-difluorophenyl)sulfonyl]-5-(1-piperazinyl)phenyl]acetamide,
(5)
N-[2-[(3,5-difluorophenyl)sulfonyl]-5-(1-piperazinyl)phenyl]acetamide-
, (6)
N-methyl-N-[2-(phenylsulfonyl)-5-(1-piperazinyl)phenyl]acetamide,
(7)
N-[2-[(3-fluorophenyl)sulfonyl]-5-(1-piperazinyl)phenyl]-N-methylacet-
amide, (8)
N-[2-[(4-fluorophenyl)sulfonyl]-5-(1-piperazinyl)phenyl]-N-meth-
ylacetamide, (9)
N-[2-[(3,4-difluorophenyl)sulfonyl]-5-(1-piperazinyl)phen-
yl]-N-methylacetamide, (10)
N-[2-[(3,5-difluorophenyl)sulfonyl]-5-(1-piper-
azinyl)phenyl]-N-methylacetamide, (11)
N-ethyl-N-[2-(phenylsulfonyl)-5-(1-- piperazinyl)phenyl]acetamide,
(12) N-ethyl-N-[2-[(3-fluorophenyl)sulfonyl]-
-5-(1-piperazinyl)phenyl]acetamide, (13)
N-ethyl-N-[2-[(4-fluorophenyl)sul-
fonyl]-5-(1-piperazinyl)phenyl]acetamide, (14)
N-ethyl-N-[2-[(3,4-difluoro-
phenyl)sulfonyl]-5-(1-piperazinyl)phenyl]acetamide, (15)
N-ethyl-N-[2-[(3,5-difluorophenyl)sulfonyl]-5-(1-piperazinyl)phenyl]aceta-
mide, (16)
N-[2-(phenylsulfonyl)-5-(1-piperazinyl)phenyl]-N-propylacetamid- e,
(17)
N-[2-[(3-fluorophenyl)sulfonyl]-5-(1-piperazinyl)phenyl]-N-propyla-
cetamide, (18)
N-[2-[(4-fluorophenyl)sulfonyl]-5-(1-piperazinyl)phenyl]-N--
propylacetamide, (19)
N-[2-[(3,4-difluorophenyl)sulfonyl]-5-(1-piperazinyl-
)phenyl]-N-propylacetamide, (20)
N-[2-[(3,5-difluorophenyl)sulfonyl]-5-(1--
piperazinyl)phenyl]-N-propylacetamide, (21)
N-[5-(4-methyl-1-piperazinyl)-- 2-(phenylsulfonyl)phenyl]acetamide,
(22) N-[2-[(3-fluorophenyl)sulfonyl]-5-
-(4-methyl-1-piperazinyl)phenyl]acetamide, (23)
N-[2-[(4-fluorophenyl)sulf-
onyl]-5-(4-methyl-1-piperazinyl)phenyl]acetamide, (24)
N-[2-[(3,4-difluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)phenyl]acet-
amide, (25)
N-[2-[(3,5-difluorophenyl)sulfonyl-5-(4-methyl-1-piperazinyl)p-
henyl]acetamide, (26)
N-methyl-N-[5-(4-methyl-1-piperazinyl)-2-(phenylsulf-
onyl)phenyl]acetamide, (27)
N-[2-[(3-fluorophenyl)sulfonyl]-5-(4-methyl-1--
piperazinyl)phenyl]-N-methylacetamide, (28)
N-[2-[(4-fluorophenyl)sulfonyl-
]-5-(4-methyl-1-piperazinyl)phenyl]-N-methylacetamide, (29)
N-[2-[(3,4-difluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)phenyl]-N-m-
ethylacetamide, (30)
N-[2-[(3,5-difluorophenyl)sulfonyl]-5-(4-methyl-1-pip-
erazinyl)phenyl]-N-methylacetamide, (31)
N-ethyl-N-[5-(4-methyl-1-piperazi-
nyl)-2-(phenylsulfonyl)phenyl]acetamide, (32)
N-ethyl-N-[2-[(3-fluoropheny-
l)sulfonyl]-5-(4-methyl-1-piperazinyl)phenyl]acetamide, (33)
N-ethyl-N-[2-[(4-fluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)phenyl]-
acetamide, (34)
N-ethyl-N-[2-[(3,4-difluorophenyl)sulfonyl]-5-(4-methyl-1--
piperazinyl)phenyl]-N-ethyl acetamide, (35)
N-ethyl-N-[2-[(3,5-difluorophe- nyl)sulfonyl]-5-(4-methyl-1-(36)
piperazinyl)phenyl]acetamide, (36)
N-[5-(4-methyl-1-piperazinyl)-2-(phenylsulfonyl)phenyl]-N-propylacetamide-
, (37)
N-[2-[(3-fluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)phenyl]-N-
-propylacetamide, (38)
N-[2-[(4-fluorophenyl)sulfonyl]-5-(4-methyl-1-piper-
azinyl)phenyl]-N-propylacetamide, (39)
N-[2-[(3,4-difluorophenyl)sulfonyl]-
-5-(4-methyl-1-piperazinyl)phenyl]-N-propylacetamide, or (40)
N-[2-[(3,5-difluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)phenyl]-N-p-
ropylacetamide, or a pharmaceutically acceptable salt thereof.
44. A compound selected from a group consisting of: (1)
2-[(3,4-difluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)phenylamine,
(2)
2-[(3,5-difluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)phenylamin-
e, (3)
N-methyl-N-[5-(4-methyl-1-piperazinyl)-2-(phenylsulfonyl)phenyl]ami-
ne, (4)
N-[2-[(3-fluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)phenyl]--
N-methylamine, (5)
N-[2-[(4-fluorophenyl)sulfonyl]-5-(4-methyl-1-piperazin-
yl)phenyl]-N-methylamine, (6)
N-[2-[(3,4-difluorophenyl)sulfonyl]-5-(4-met-
hyl-1-piperazinyl)phenyl]-N-methylamine, (7)
N-[2-[(3,5-difluorophenyl)sul-
fonyl]-5-(4-methyl-1-piperazinyl)phenyl]-N-methylamine, (8)
N-ethyl-N-[5-(4-methyl-1-piperazinyl)-2-(phenylsulfonyl)phenyl]amine,
(9)
N-ethyl-N-[2-[(3-fluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)phenyl]-
amine, (10)
N-ethyl-N-[2-[(4-fluorophenyl)sulfonyl]-5-(4-methyl-1-piperazi-
nyl)phenyl]amine, (11)
N-ethyl-N-[2-[(3,4-difluorophenyl)sulfonyl]-5-(4-me-
thyl-1-piperazinyl)phenyl]amine, (12)
N-ethyl-N-[2-[(3,5-difluorophenyl)su-
lfonyl]-5-(4-methyl-1-piperazinyl)phenyl]amine, (13)
N-[5-(4-methyl-1-piperazinyl)-2-(phenylsulfonyl)phenyl]-N-propyl
amine, (14)
N-[2-[(3-fluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)phenyl]-N--
propylamine, (15)
N-[2-[(4-fluorophenyl)sulfonyl]-5-(4-methyl-1-piperaziny-
l)phenyl]-N-propylamine, (16)
N-[2-[(3,4-difluorophenyl)sulfonyl]-5-(4-met-
hyl-1-piperazinyl)phenyl]-N-propylamine, (17)
N-[2-[(3,5-difluorophenyl)su-
lfonyl]-5-(4-methyl-1-piperazinyl)phenyl]-N-propylamine, (18)
N,N-dimethyl-N-[5-(4-methyl-1-piperazinyl)-2-(phenylsulfonyl)phenyl]amine-
, (19)
N-[2-[(3-fluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)phenyl]-N-
,N-dimethylamine, (20)
N-[2-[(4-fluorophenyl)sulfonyl]-5-(4-methyl-1-piper-
azinyl)phenyl]-N,N-dimethylamine, (21)
N-[2-[(3,4-difluorophenyl)sulfonyl]-
-5-(4-methyl-1-piperazinyl)phenyl]-N,N-dimethylamine, (22)
N-[2-[(3,5-difluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)phenyl]-N,N-
-dimethylamine, (23)
N,N-diethyl-N-[5-(4-methyl-1-piperazinyl)-2-(phenylsu-
lfonyl)phenyl]amine, (24)
N,N-diethyl-N-[2-[(3-fluorophenyl)sulfonyl]-5-(4-
-methyl-1-piperazinyl)phenyl]amine, (25)
N,N-diethyl-N-[2-[(4-fluorophenyl-
)sulfonyl]-5-(4-methyl-1-piperazinyl)phenyl]amine, (26)
N,N-diethyl-N-[2-[(3,4-difluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl-
)phenyl]amine, (27)
N,N-diethyl-N-[2-[(3,5-difluorophenyl)sulfonyl]-5-(4-m-
ethyl-1-piperazinyl)phenyl]amine, (28)
N-[5-(4-methyl-1-piperazinyl)-2-(ph-
enylsulfonyl)phenyl]-N,N-dipropylamine, (29)
N-[2-[(3-fluorophenyl)sulfony-
l]-5-(4-methyl-1-piperazinyl)phenyl]-N,N-dipropylamine, (30)
N-[2-[(4-fluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)phenyl]-N
N-dipropylamine, (31)
N-[2-[(3,4-difluorophenyl)sulfonyl]-5-(4-methyl-1-p-
iperazinyl)phenyl]-N,N-dipropylamine, (32)
N-[2-[(3,5-difluorophenyl)sulfo-
nyl]-5-(4-methyl-1-piperazinyl)phenyl-N,N-dipropylamine, or a
pharmaceutically acceptable salt thereof.
45. A pharmaceutically acceptable composition comprising a compound
of claim 1 and a pharmaceutically acceptable carrier.
46. A pharmaceutically acceptable composition comprising a compound
of claim 11 and a pharmaceutically acceptable carrier.
47. A pharmaceutically acceptable composition comprising a compound
of claim 36 and a pharmaceutically acceptable carrier.
48. A pharmaceutically acceptable composition comprising a compound
of claim 37 and a pharmaceutically acceptable carrier.
49. A pharmaceutically acceptable composition comprising a compound
of claim 38 and a pharmaceutically acceptable carrier.
Description
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This application is a continuation of U.S. application Ser.
No. 09/877,308 filed Jun. 8, 2001, which claims the benefit of the
following provisional applications: U.S. Serial No. 60/212,894,
filed Jun. 20, 2000; U.S. Serial No. 60/237,025, filed Sep. 29,
2000; U.S. Serial No. 60/239,713, filed Oct. 12, 2000 and U.S.
Serial No. 60/268,261, filed Feb. 13, 2001, under 35 USC
119(e)(i).
FIELD OF THE INVENTION
[0002] The present invention relates to novel bis-arylsulfone
derivatives, and more specifically, relates to bis-arylsulfone
compounds of formula I described herein below. These compounds are
5-HT receptor ligands and are useful for treating diseases wherein
modulation of 5-HT activity is desired.
BACKGROUND OF THE INVENTION
[0003] Serotonin has been implicated in a number of diseases and
conditions that originate in the central nervous system. These
include diseases and conditions related to sleeping, eating,
perceiving pain, controlling body temperature, controlling blood
pressure, depression, anxiety, schizophrenia, and other bodily
states. Serotonin also plays an important role in peripheral
systems, such as the gastrointestinal system, where it has been
found to mediate a variety of contractile, secretory, and
electrophysiologic effects.
[0004] As a result of the broad distribution of serotonin within
the body, there is a tremendous interest in drugs that affect
serotonergic systems. In particular, agonists, partial agonists and
antagonists are of interest for the treatment of a wide range of
disorders, including anxiety, depression, hypertension, migraine,
obesity, compulsive disorders, schizophrenia, autism,
neurodegenerative disorders (e.g. Alzheimer's disease,
Parkinsonism, and Huntington's chorea), and chemotherapy-induced
vomiting.
[0005] The major classes of serotonin receptors (5-HT.sub.1-7)
contain fourteen to eighteen separate receptors that have been
formally classified. See Glennon, et al., Neuroscience and
Behavioral Reviews, 1990, 14, 35; and D. Hoyer, et al. Pharmacol.
Rev. 1994, 46, 157-203.
[0006] There is currently a need for pharmaceutical agents that are
useful to treat diseases and conditions that are associated with
5-HT receptors. In particular, there is a need for agents that can
selectively bind to individual receptor subtypes (e.g.
receptor-specific agonists or antagonists); such agents would be
useful as pharmaceutical agents, or would be useful to facilitate
the study of the 5-HT receptor family, or to aid in the
identification of other compounds that selectively bind to the
specific 5-HT receptors.
[0007] For example, the 5-HT.sub.6 receptor is identified in 1993
(Monsma et al. Mol. Pharmacol. 1993, 43, 320-327 and Ruat, M. et
al. Biochem. Biophys. Res. Com. 1993, 193, 269-276). Several
antidepressants and a typical antipsychotics bind to the 5-HT.sub.6
receptor with high affinity and this binding may be a factor in
their profile of activities (Roth et al. J. Pharm. Exp. Therapeut.
1994, 268, 1403-1410; Sleight et al. Exp. Opin. Ther. Patents 1998,
8, 1217-1224; Bourson et al. Brit. J. Pharm. 1998, 125, 1562-1566;
Boess et al. Mol. Pharmacol. 1998, 54, 577-583; Sleight et al.
Brit. J. Pharmacol. 1998, 124, 556-562). In addition, the
5-HT.sub.6 receptor has been linked to generalized stress and
anxiety states (Yoshioka et al. Life Sciences 1998, 17/18,
1473-1477). Together these studies and observations suggest that
compounds that antagonize the 5-HT.sub.6 receptor will be useful in
treating disorders of the central nervous system.
[0008] Generally, compounds of the present invention are 5-HT
ligands. In particular, they can selectively bind to the 5-HT.sub.6
receptor (e.g. receptor-specific agonists or antagonists). Thus,
they are useful for treating diseases wherein modulation of 5-HT
activity, specifically 5-HT.sub.6 activity, is desired. Therefore,
the compounds of this invention are useful for the treatment of
diseases or disorders of the central nervous system. More
specifically, for the treatment of psychosis, paraphrenia,
psychotic depression, mania, schizophrenia, schizophreniform
disorders, anxiety, migraine headache, drug addiction, convulsive
disorders, personality disorders, post-traumatic stress syndrome,
alcoholism, panic attacks, obsessive-compulsive disorders, and
sleep disorders. The compounds of this invention are also useful to
treat psychotic, affective, vegetative, and psychomotor symptoms of
schizophrenia and the extrapyramidal motor side effects of other
antipsychotic drugs. This last action will allow higher doses of
antipsychotics to be used and thus greater antipsychotic efficacy
to be obtained as a result of a reduction in side effects. The
compounds of this invention are also useful in the modulation of
eating behavior and thus are useful in treating excess weight and
associated morbidity and mortality.
INFORMATION DISCLOSURE
[0009] U.S. Pat. No. 5,627,077 discloses aniline compounds useful
in making mineral oils.
[0010] U.S. Pat. No. 4,851,423 discloses pharmaceutically active
compounds having antiviral and antiinflammatory.
[0011] PCT International Publication WO 99/37623 discloses novel
compounds having pharmacological activity for the treatment of CNS
disorders.
[0012] PCT International Publication WO 99/47516 discloses
3-(2-pyrrolidinylmethyl)-indole compound having 5-HT6 affinity.
[0013] PCT International Publication WO 99/42465 discloses novel
sulphonamide derivatives having CNS activity.
[0014] PCT International Publication WO 99/02502 discloses novel
compounds having pharmacological activity for the treatment of CNS
disorders.
[0015] PCT International Publication WO 93/17682 discloses
angiotensin II receptor antagonists.
[0016] PCT International Publication WO 92/06683 discloses
pharmaceutical compositions having anti-retrovirus activity.
[0017] PCT International Publication WO 92/20642 discloses bis or
mono bicyclic aryl and/or heteroaryl compounds exhibiting protein
tyrosine kinase inhibition activity.
[0018] Abstract of PCT International Publication WO 92/9408956A
discloses compounds useful for depress blood lipid levels.
[0019] Abstract of JO 3056-431-a discloses diphenyl compounds
having analgesic, anti-inflammatory, anti-rheumatic, and
anti-nephritic activity.
[0020] Abstract of JP 07033735-A discloses diphenyl-sulphone
compounds useful for treating inflammation, allergies and
asthma.
[0021] Abstract of WO 9318035 discloses angiotensin II receptor
containing fused heterocycle and two phenyl rings.
[0022] Abstract of WO 9707790 discloses compounds containing
diphenyl for treating infectious infectious diseases such as
malaria.
SUMMARY OF THE INVENTION
[0023] The present invention provides novel compounds of formula I:
1
[0024] or a pharmaceutically acceptable salt thereof wherein
[0025] R.sup.1 is H, C.sub.1-12 alkyl, C.sub.1-6 alkylaryl, or
aryl; each R.sup.2 is independently H, C.sub.1-12 alkyl, C.sub.1-12
alkenyl, halo, NO.sub.2, CN, CF.sub.3, or OR.sup.1; each R.sup.3 is
independently H, C.sub.1-12 alky, C.sub.1-12 alkenyl, or R.sup.4;
R.sup.4 is halo, NO.sub.2, CN, CF.sub.3, OR.sup.1,
CONR.sup.1R.sup.1, NHSO.sub.2R.sup.1, NR.sup.1R.sup.1,
NR.sup.1COR.sup.1, SO.sub.2NR.sup.1R.sup.1, C(.dbd.O)R.sup.1,
CO.sub.2R.sup.1, or S(O).sub.iR.sup.1; each R.sup.5 is
independently H, C.sub.1-6 alkyl, C.sub.1-6 alkylaryl, aryl,
C(.dbd.O)R.sup.1, S(O).sub.2R.sup.1, C(O)NR.sup.1R.sup.1,
CO.sub.2R.sup.1, or CSR.sup.1; at each occurrence, alkyl, alkenyl,
alkyaryl or aryl is optionally substituted with one or more
R.sup.4;
[0026] i is 0, 1, or 2; m is 1, 2 or 3; and n is 1, 2, 3, 4, or
5.
[0027] The present invention further provides novel compounds of
formula II: 2
[0028] or a pharmaceutically acceptable salt thereof wherein
R.sup.6 is H, or C.sub.1-4 alkyl; R.sup.7 is H, halo, C.sub.1-4
alkyl, or NR.sup.6R.sup.6; R.sup.8 is H, halo, or C.sub.1-4 alkyl;
and each R.sup.9 is independently H, C.sub.1-4 alkyl,
C(.dbd.O)R.sup.10, S(O).sub.2R.sup.10, C(O)NR.sup.10R.sup.11,
CO.sub.2R.sup.10, or CSR.sup.10; and each R.sup.10 is independently
H, C.sub.1-12 alkyl, C.sub.1-6 alkylaryl, or aryl.
[0029] The present invention further provides a pharmaceutical
composition comprising a compound of formula I or II, or a
pharmaceutically acceptable salt thereof, and a pharmaceutically
acceptable carrier. In preferred embodiments, the composition
preferably comprises a therapeutically effective amount of a
compound of formula I or a pharmaceutically acceptable salt
thereof.
[0030] The present invention further provides a method for treating
a disease or condition in a mammal wherein a 5-HT receptor is
implicated and modulation of a 5-HT function is desired comprising
administering to the mammal a therapeutically effective amount of a
compound of formula III 3
[0031] or a pharmaceutically acceptable salt thereof wherein
[0032] R.sup.1 is H, C.sub.1-12 alkyl, C.sub.1-6 alkylaryl, or
aryl; each R.sup.2 is independently H, C.sub.1-12 alkyl, C.sub.1-12
alkenyl, halo, NO.sub.2, CN, CF.sub.3, or OR.sup.1; each R.sup.3 is
independently H, C.sub.1-12 alkyl, C.sub.1-12 alkenyl, or R.sup.4;
R.sup.4 is halo, NO.sub.2, CN, CF.sub.3, OR.sup.1,
CONR.sup.1R.sup.1, NHSO.sub.2R.sup.1, NR.sup.1R.sup.1,
NR.sup.1COR.sup.1, SO.sub.2NR.sup.1R.sup.1, C(.dbd.O)R.sup.1,
CO.sub.2R.sup.1, or S(O).sub.iR.sup.1; each R.sup.5 is
independently H, C.sub.1-6 alkyl, C.sub.1-6 alkylaryl, aryl,
C(.dbd.O)R.sup.1, S(O).sub.2R.sup.1, C(O)NR.sup.1R.sup.1,
CO.sub.2R.sup.1, or CSR.sup.1; at each occurrence, alkyl, alkenyl,
alkyaryl or aryl is optionally substituted with one or more
R.sup.4; k is 1 or 2; i is 0, 1, or 2; m is 1, 2 or 3; and n is 1,
2, 3, 4, or 5.
[0033] The present invention further provides a method for treating
a disease or condition in a mammal wherein a 5-HT.sub.6 receptor is
implicated and modulation of a 5-HT.sub.6 function is desired
comprising administering to the mammal a therapeutically effective
amount of a compound of formula III, or a pharmaceutically
acceptable salt thereof.
[0034] The present invention further provides a method for treating
or preventing diseases or disorders of the central nervous system
comprising administering a therapeutically effective amount of a
compound of formula III, or a pharmaceutically acceptable salt
thereof to the mammal. Diseases or disorders for which a compound
of formula I may have activity include, but are not limited to the
following: obesity, depression, schizophrenia, schizophreniform
disorder, schizoaffective disorder, delusional disorder, a stress
related disease (e.g. general anxiety disorder), panic disorder, a
phobia, obsessive compulsive disorder, post-traumatic-stress
syndrome, immune system depression, major depression, a stress
induced problem with the urinary, gastrointestinal or
cardiovascular system (e.g., stress incontinence),
neurodegenerative disorders, autism, chemotherapy-induced vomiting,
hypertension, migraine headaches, cluster headaches, sexual
dysfunction in a mammal (e.g. a human), addictive disorder and
withdrawal syndrome, an adjustment disorder, an age-associated
learning and mental disorder, anorexia nervosa, apathy, an
attention-deficit disorder due to general medical conditions,
attention-deficit hyperactivity disorder, behavioral disturbance
(including agitation in conditions associated with diminished
cognition (e.g., dementia, mental retardation or delirium)),
bipolar disorder, bulimia nervosa, chronic fatigue syndrome,
conduct disorder, cyclothymic disorder, dysthymic disorder,
fibromyalgia and other somatoform disorders, generalized anxiety
disorder, an inhalation disorder, an intoxication disorder,
movement disorder (e.g., Huntington's disease or Tardive
Dyskinesia), oppositional defiant disorder, peripheral neuropathy,
post-traumatic stress disorder, premenstrual dysphoric disorder, a
psychotic disorder (brief and long duration disorders, psychotic
disorder due to medical condition, psychotic disorder NOS), mood
disorder (major depressive or bipolar disorder with psychotic
features) seasonal affective disorder, a sleep disorder, cognitive
disorders, iritable bowel syndrome, a specific developmental
disorder, agitation disorder, selective serotonin reuptake
inhibition (SSRI) "poop out" syndrome or a Tic disorder (e.g.,
Tourette's syndrome).
[0035] The present invention further provides a method for treating
anxiety, or stress related disorders comprising administering a
therapeutically effective amount of a compound of formula III, or a
pharmaceutically acceptable salt thereof to the mammal.
[0036] The present invention further provides a method for treating
depression comprising administering a therapeutically effective
amount of a compound of formula III, or a pharmaceutically
acceptable salt thereof to the mammal.
[0037] The present invention further provides a method for treating
obesity comprising administering a therapeutically effective amount
of a compound of formula III, or a pharmaceutically acceptable salt
thereof to the mammal.
[0038] The present invention further provides the use of a compound
of formula III or a pharmaceutically acceptable salt thereof to
prepare a medicament for treating or preventing diseases or
disorders of the central nervous system.
[0039] The present invention further provides a composition of
formula I and a pharmaceutically acceptable carrier.
[0040] The present invention further provides a composition of
formula II and a pharmaceutically acceptable carrier.
[0041] The invention may also provide novel intermediates and
processes for preparing compounds of formula III.
DETAILED DESCRIPTION OF THE INVENTION
[0042] The compounds of the present invention are generally named
according to the IUPAC or CAS nomenclature system. Abbreviations
which are well known to one of ordinary skill in the art may be
used (e.g. "Ph" for phenyl, "Me" for methyl, "Et" for ethyl, "h"
for hour or hours, "rt" for room temperature, and etc.).
[0043] The carbon atom content of various hydrocarbon-containing
moieties is indicated by a prefix designating the minimum and
maximum number of carbon atoms in the moiety, i.e., the prefix
C.sub.i-j indicates a moiety of the integer "i" to the integer "j"
carbon atoms, inclusive. Thus, for example, C.sub.1-7alkyl refers
to alkyl of one to seven carbon atoms, inclusive.
[0044] Specific and preferred values listed below for radicals,
groups, moieties, substituents, or ranges, are for illustration
only; they do not exclude other defined values or other values
within defined ranges.
[0045] The following definitions are used, unless otherwise
described.
[0046] The term "halo" denotes fluoro, chloro, bromo, or iodo.
[0047] Alkyl denotes both straight and branched groups; but
reference to an individual group or moiety such as "propyl"
embraces only the straight chain group or moiety, a branched chain
isomer such as "isopropyl" being specifically referred to.
[0048] Aryl denotes a phenyl radical or an ortho-fused bicyclic
carbocyclic group or moiety having about nine to ten ring atoms in
which at least one ring is aromatic.
[0049] Mammal denotes human and animals.
[0050] It is to be understood that the present invention
encompasses any racemic, optically-active, polymorphic, tautomeric,
or stereoisomeric form, or mixture thereof, of a compound of the
invention, which possesses the useful properties described
herein.
[0051] In cases where compounds are sufficiently basic or acidic to
form stable nontoxic acid or base salts, administration of the
compounds as salts may be appropriate. Examples of pharmaceutically
acceptable salts are organic acid addition salts formed with acids
which form a physiological acceptable anion, for example, tosylate,
methanesulfonate, acetate, citrate, malonate, tartarate, succinate,
benzoate, ascorbate, .alpha.-ketoglutarate, maleate, fumarate,
benzenesulfonate and .alpha.-glycerophosphate. Suitable inorganic
salts may also be formed, including hydrobromide, hydrochloride,
sulfate, nitrate, bicarbonate, and carbonate salts.
[0052] Pharmaceutically acceptable salts may be obtained using
standard procedures well known in the art, for example by reacting
a sufficiently basic compound such as an amine with a suitable acid
affording a physiologically acceptable anion. Alkali metal (for
example, sodium, potassium or lithium) or alkaline earth metal (for
example calcium) salts of carboxylic acids can also be made.
[0053] In one embodiment, R.sup.1 is H or C.sub.1-4alkyl.
[0054] In another embodiment, R.sup.1 is methyl.
[0055] In one embodiment, R.sup.1 is H.
[0056] In another embodiment, each R.sup.2 is independently H or
C.sub.1-6alkyl.
[0057] In another embodiment, R.sup.1 is H.
[0058] In one embodiment, each R.sup.3 is independently H, fluoro
or C.sub.1-4alkyl.
[0059] In one embodiment, each R.sup.3 is fluoro, n is one or
two.
[0060] In one embodiment, each R.sup.5 is H independently or
C.sub.1-4alkyl.
[0061] In one embodiment, R.sup.5 is H.
[0062] In one embodiment, each R.sup.5 is independently H, or
C(.dbd.O)R.sup.1.
[0063] In one embodiment, each R.sup.5 is independently H, or
C(.dbd.O)RCH.sub.3.
[0064] In one embodiment, each R.sup.5 is independently H,
S(O).sub.2R.sup.1, C(O)NR.sup.1R.sup.1, CO.sub.2R.sup.1, or
CSR.sup.1.
[0065] In one embodiment, R.sup.6 is H, methyl or ethyl.
[0066] In one embodiment, R.sup.7 is H.
[0067] In one embodiment, R.sup.8 is H or fluoro, or methyl.
[0068] Examples of the present invention are:
[0069] (1)
5-(1,4-diazepan-1-yl)-2-[(3-fluorophenyl)sulfonyl]phenylamine,
[0070] (2)
5-(1,4-diazepan-1-yl)-2-[(3,4-difluorophenyl)sulfonyl]phenylami-
ne,
[0071] (3) 5-(1,4-diazepan-1-yl)-2-(phenylsulfonyl)phenylamine,
[0072] (4)
5-(1,4-diazepan-1-yl)-2-[(3,5-difluorophenyl)sulfonyl]phenylami-
ne,
[0073] (5)
5-(1,4-diazepan-1-yl)-2-[(3-fluorophenyl)sulfonyl]-N-methylphen-
ylamine,
[0074] (6)
5-(1,4-diazepan-1-yl)-N-ethyl-2-[(3-fluorophenyl)sulfonyl]anili-
ne,
[0075] (7)
5-(1,4-diazepan-1-yl)-N,N-diethyl-2-[(3-fluorophenyl)sulfonyl]p-
henylamine,
[0076] (8) N-[5-(1,4-diazepan-1-yl)-2-(phenylsulfonyl)
phenyl]acetamide,
[0077] (9)
N-[2-[(3-fluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-yl)p-
henyl]acetamide, or
[0078] (10) N-[5-(1,4-diazepan-1-yl)-2-[(3-fluorophenyl)
sulfonyl]phenyl]-N-ethylacetamide, or a pharmaceutically acceptable
salt thereof.
[0079] Another examples of the present invention are:
[0080] (1) 2-(phenylsulfonyl)-5-(1-piperazinyl)phenylamine,
[0081] (2)
2-[(4-fluorophenyl)sulfonyl]-5-(1-piperazinyl)phenylamine,
[0082] (3)
2-[(4-fluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)phenylam-
ine,
[0083] (4)
2-[(4-methylphenyl)sulfonyl]-5-(1-piperazinyl)phenylamine,
[0084] (5)
2-[(4-methylphenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)phenylam-
ine,
[0085] (6)
5-(4-methyl-1-piperazinyl)-2-(phenylsulfonyl)phenylamine,
[0086] (7)
2-[(3-fluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)phenylam-
ine, or
[0087] (8) N-ethyl-2-(phenylsulfonyl)-5-(1-piperazinyl)phenylamine,
or a pharmaceutically acceptable salt thereof.
[0088] Specific example of the present invention is
N-[5-(1,4-diazepan-1-yl)-2-[(3-fluorophenyl)sulfonyl]phenyl]acetamide,
or its pharmaceutically acceptable salt thereof.
[0089] Specific example of the present invention is
5-(1,4-diazepan-1-yl)-2-(phenylsulfonyl) phenylamine, or its
pharmaceutically acceptable salt thereof.
[0090] Specific example of the present invention is
N-[5-(1,4-diazepan-1-yl)-2-(phenylsulfonyl) phenyl]acetamide, or
its pharmaceutically acceptable salt thereof.
[0091] Chart I and Chart II describe the preparation of compounds
of the present invention. All of the starting materials are
prepared by procedures described herein or by procedures that would
be well known to one of ordinary skill in organic chemistry. As
shown in Chart I, treatment of commercially available substituted
or unsubstituted 2,5-difluoronitro-benzene 1 with the desired
arylthiol gave thioether 2. This reaction is usually carried out in
the presence of a suitable base such as potassium carbonate and a
suitable solvent such as acetonitrile. The oxidation of 2 to
sulfone 3 is usually carried out using m-CPBA (in CH.sub.2Cl.sub.2)
or H.sub.2O.sub.2 (in hot acetic acid) as the oxidizing agents.
When using m-CPBA, the reaction is done at ambient temperature in a
solvent such as CH.sub.2Cl.sub.2. The desired arylpiperazine moiety
4 is formed by a second nucleophilic substitution reaction, using
the appropriate amine. Again, this displacement is done using
potassium carbonate as the base and a solvent such as acetonitrile.
Depending on the R.sup.1-substituent, reduction of nitrobenzene 4
to the aniline 5 is accomplished using Raney nickel and hydrazine.
The solvent system most typically utilized is EtOH/THF. If further
purification of 5 is desired, piperazine 4 is protected as the
tert-butyl carbamate using di-tert-butyl dicarbonate (THF,
H.sub.2O) to give carbamate 6. This compound is reduced as
described above using Raney Nickel, to give aniline 7. In contrast
to compound 5, carbamate 7 can be readily purified by
chromatography. Deprotection using TFA in CH.sub.2Cl.sub.2 provided
bis-sulfone 5. If desired, carbamate 7 can be alkylated to give
compound of structure 8. In this case, treatment of 7 with
methyltriflate in the presence of potassium hydride gives the
methylamine 8. Deprotection, as described above, using TFA in
CH.sub.2Cl.sub.2 provides a compound of structure 5. 4
[0092] Alternatively, N-alkylated compound of structure 5 can be
prepared according to CHART II as shown here. Reaction of a
compound of structure 2 with a desired piperazine, as decribed in
Chart I (potassium carbonate/acetonitrile; at ambient to elevated
temperatures), provideds piperazine 9. Protection of 9 using
di-tert-butyl dicarbonate provided carbamate 10. Reduction of nitro
10 using Raney nickel and hydrazine gives aniline 11, which can be
readily reacted with acetyl chloride to give 12. This reaction is
carried out quite effectively using acetyl chloride (or other acyl
chlorides or ethyl formate), in the presence of DMAP, and Hunigs
base, in a suitable solvent such as CH.sub.2Cl.sub.2. Oxidation of
12 to the sulfone is accomplished with m-CPBA (CH.sub.2Cl.sub.2,
-78.degree. C.-rt) to give 13. Reduction of amide 13 utilizing
borane-methylsulfide complex gives the desired alkylamine 14. The
piperazine is the deprotected and alkylated to provide a compound
of structure 5. If desired, a dialkylated compound can also be
prepared according to the methods well-known in the art. If
desired, amides such as 13 in Chart II may be simply deprotected
using either TFA, HCl in EthOH, or TsOH to give acetamide 5
(R5=COCH.sub.3). Sulfonamides can be prepared in a similar fashion.
5
[0093] The inventive compounds may be used in their native form or
as salts. In cases where compounds are sufficiently basic or acidic
to form stable nontoxic acid or base salts, administration of the
compounds as salts may be appropriate. Examples of pharmaceutically
acceptable salts are organic acid addition salts formed with acids
which form a physiological acceptable anion, for example, tosylate,
methanesulfonate, acetate, citrate, malonate, tartarate, succinate,
benzoate, ascorbate, etoglutarate, and glycerophosphate. Suitable
inorganic salts may also be formed, including hydrochloride,
sulfate, nitrate, bicarbonate, and carbonate salts.
[0094] Pharmaceutically acceptable salts may be obtained using
standard procedures well known in the art, for example by reacting
a sufficiently basic compound such as an amine with a suitable acid
affording a physiologically acceptable anion. Alkali metal (for
example, sodium, potassium or lithium) or alkaline earth metal (for
example calcium) salts of carboxylic acids can also be made.
[0095] Compounds of the present invention can conveniently be
administered in a pharmaceutical composition containing the
compound in combination with a suitable excipient, the composition
being useful in combating CNS diseases. Pharmaceutical compositions
containing a compound appropriate for CNS diseases' use are
prepared by methods and contain excipients which are well known in
the art. A generally recognized compendium of such methods and
ingredients is Remington's Pharmaceutical Sciences by E. W. Martin
(Mark Publ. Co., 15th Ed., 1975). The compounds and compositions of
the present invention can be administered parenterally (for
example, by intravenous, intraperitoneal or intramuscular
injection), topically (including but not limited to surface
treatment, transdermal application, and nasal application),
intravaginally, orally, or rectally, depending on whether the
preparation is used to treat a specific disease.
[0096] For oral therapeutic administration, the active compound may
be combined with one or more excipients and used in the form of
ingestible tablets, buccal tablets, troches, capsules, elixirs,
suspensions, syrups, wafers, and the like. Such compositions and
preparations should contain at least 0.1% of active compound. The
percentage of the compositions and preparations may, of course, be
varied and may conveniently be between about 2 to about 60% of the
weight of a given unit dosage form. The amount of active compound
in such therapeutically useful compositions is such that an
effective dosage level will be obtained.
[0097] The tablets, troches, pills, capsules, and the like may also
contain the following: binders such as gum tragacanth, acacia, corn
starch or gelatin; excipients such as dicalcium phosphate; a
disintegrating agent such as corn starch, potato starch, alginic
acid and the like; a lubricant such as magnesium stearate; and a
sweetening agent such as sucrose, fructose, lactose or aspartame or
a flavoring agent such as peppermint, oil of wintergreen, or cherry
flavoring may be added. When the unit dosage form is a capsule, it
may contain, in addition to materials of the above type, a liquid
carrier, such as a vegetable oil or a polyethylene glycol. Various
other materials may be present as coatings or to otherwise modify
the physical form of the solid unit dosage form. For instance,
tablets, pills, or capsules may be coated with gelatin, wax,
shellac or sugar and the like. A syrup or elixir may contain the
active compound, sucrose or fructose as a sweetening agent, methyl
and propylparabens as preservatives, a dye and flavoring such as
cherry or orange flavor. Of course, any material used in preparing
any unit dosage form should be pharmaceutically acceptable and
substantially non-toxic in the amounts employed. In addition, the
active compound may be incorporated into sustained-release
preparations and devices such as the osmotic release type devices
developed by the Alza Corporation under the OROS trademark.
[0098] The compounds or compositions can also be administered
intravenously or intraperitoneally by infusion or injection.
Solutions of the active compound or its salts can be prepared in
water, optionally mixed with a nontoxic surfactant. Dispersions can
also be prepared in glycerol, liquid polyethylene glycols,
triacetin, and mixtures thereof and in oils. Under ordinary
conditions of storage and use, these preparations contain a
preservative to prevent the growth of microorganisms.
[0099] Pharmaceutical dosage forms suitable for injection or
infusion can include sterile aqueous solutions or dispersions or
sterile powders comprising the active ingredient which are adapted
for the extemporaneous preparation of sterile injectable or
infusible solutions or dispersions, optionally encapsulated in
liposomes. In all cases, the ultimate dosage form should be
sterile, fluid and stable under the conditions of manufacture and
storage. The liquid carrier or vehicle can be a solvent or liquid
dispersion medium comprising, for example, water, ethanol, a polyol
(for example, glycerol, propylene glycol, liquid polyethylene
glycols, and the like), vegetable oils, nontoxic glyceryl esters,
and suitable mixtures thereof. The proper fluidity can be
maintained, for example, by the formation of liposomes, by the
maintenance of the required particle size in the case of
dispersions or by the use of surfactants. The prevention of the
action of microorganisms can be brought about by various
antibacterial and antifungal agents, for example, parabens,
chlorobutanol, phenol, sorbic acid, thimerosal, and the like. In
many cases, it will be preferable to include isotonic agents, for
example, sugars, buffers or sodium chloride. Prolonged absorption
of the injectable compositions can be brought about by the use in
the compositions of agents delaying absorption, for example,
aluminum monostearate and gelatin.
[0100] Sterile injectable solutions can be prepared by
incorporating the active compound in the required amount in the
appropriate solvent with various of the other ingredients
enumerated above, as required, followed by filter sterilization. In
the case of sterile powders for the preparation of sterile
injectable solutions, the preferred methods of preparation are
vacuum drying and the freeze drying techniques, which yield a
powder of the active ingredient plus any additional desired
ingredient present in the previously sterile-filtered
solutions.
[0101] For topical administration, the present compounds may be
applied in pure form, i.e., when they are liquids. However, it will
generally be desirable to administer them to the skin as
compositions or formulations, in combination with a
dermatologically acceptable carrier, which may be a solid or a
liquid.
[0102] Useful solid carriers include finely divided solids such as
talc, clay, microcrystalline cellulose, silica, alumina and the
like. Useful liquid carriers include water, alcohols or glycols or
water-alcohol/glycol blends, in which the present compounds can be
dissolved or dispersed at effective levels, optionally with the aid
of non-toxic surfactants. Adjuvants such as fragrances and
additional antimicrobial agents can be added to optimize the
properties for a given use. The resultant liquid compositions can
be applied from absorbent pads, used to impregnate bandages and
other dressings, or sprayed onto the affected area using pump-type
or aerosol sprayers. Thickeners such as synthetic polymers, fatty
acids, fatty acid salts and esters, fatty alcohols, modified
celluloses or modified mineral materials can also be employed with
liquid carriers to form spreadable pastes, gels, ointments, soaps,
and the like, for application directly to the skin of the user.
[0103] Examples of useful dermatological compositions which can be
used to deliver the compounds of formula I to the skin are known to
the art; for example, see Jacquet et al. (U.S. Pat. No. 4,608,392),
Geria (U.S. Pat. No. 4,992,478), Smith et al. (U.S. Pat. No.
4,559,157) and Wortzman (U.S. Pat. No. 4,820,508).
[0104] Useful dosages of the compounds of formula I can be
determined by comparing their in vitro activity, and in vivo
activity in animal models. Methods for the extrapolation of
effective dosages in mice, and other animals, to humans are known
to the art; for example, see U.S. Pat. No. 4,938,949.
[0105] The compound is conveniently administered in unit dosage
form; for example, containing 1 to 1000 mg, conveniently 5 to 750
mg, most conveniently, 5 to 400 mg of active ingredient per unit
dosage form. The desired dose may conveniently be presented in a
single dose or as divided doses administered at appropriate
intervals, for example, as two, three, four or more sub-doses per
day. The sub-dose itself may be further divided, e.g., into a
number of discrete loosely spaced administrations; such as multiple
inhalations from an insufflator or by application of a plurality of
drops into the eye.
[0106] The compositions can be administered orally or parenterally
at dose levels, calculated as the free base, of about 0.01 to 300
mg/kg mammal body weight, preferably 0.1 to 50 mg/kg of mammal body
weight, more preferably 1.0 to 30 mg/kg of mammal body weight, and
can be used in man in a unit dosage form, administered one to four
times daily in the amount of 1 to 1000 mg per unit dose.
[0107] Generally, the concentration of the compound(s) of formula I
in a liquid composition, such as a lotion, will be from about
0.1-25 wt-%, preferably from about 0.5-10 wt-%. The concentration
in a semi-solid or solid composition such as a gel or a powder will
be about 0.1-5 wt-%, preferably about 0.5-2.5 wt-%.
[0108] The exact regimen for administration of the compounds and
compositions disclosed herein will necessarily be dependent upon
the needs of the individual subject being treated, the type of
treatment and, of course, the judgment of the attending
practitioner. The compounds of the present invention can be
administered to an animal in need of treatment. In most instances,
this will be a human being, but the treatment of livestock and
companion animals is also specifically contemplated as falling
within the scope of the instant invention.
[0109] Generally, compounds of the invention are 5-HT ligands. The
ability of a compound of the invention to bind or act at a 5-HT
receptor, or to bind or act selectively at a specific 5-HT receptor
subtype can be determined using in vitro and in vivo assays that
are known in the art. As used herein, the term "bind selectively"
means a compound binds at least 2 times, preferably at least 10
times, and more preferably at least 50 times more readily to a
given 5-HT subtype than to one or more other subtypes. Preferred
compounds of the invention bind selectively to one or more 5-HT
receptor subtypes.
[0110] The ability of a compound of the invention to act as a 5-HT
receptor agonist or antagonist can also be determined using in
vitro and in vivo assays that are known in the art. All of the
Example compounds provided above are 5-HT ligands, with the ability
to displace >50% of a radiolabeled test ligand from one or more
5-HT receptor subtypes at a concentration of 1 .mu.M. The
procedures used for testing such displacement are well known and
illustrated below.
5-HT.sub.6 Receport Binding Assay
[0111] Growth of Cells and Membrane Preparation
[0112] Hela cells containing the cloned human 5-HT.sub.6 receptor
are acquired from Dr. David R. Sibley's laboratory in National
Institute of Health (see Sibley, D. R., J. Neurochemistry, 66,
47-56, 1996). Cells are grown in high glucose Dulbecco's modified
Eagle's medium, supplemented with L-glutamine, 0.5% sodium
pyruvate, 0.3% penicillin-streptomycin, 0.025% G-418 and 5% Gibco
fetal bovine serum and then are harvested, when confluent, in cold
phosphate buffered saline.
[0113] Harvested intact cells are washed once in cold
phosphate-buffered saline. The cells are pelleted and resuspended
in 100 ml of cold 50 mM Tris, 5 mM EDTA and 5 mM EGTA, pH 7.4.
Homogenization is with a Vir Tishear generator, 4 cycles for 30
seconds each at setting 50. The homogenized cells are centrifuged
at 700 RPM (1000.times.g) for 10 minutes and the supernatant is
removed. The pellet is resuspended in 100 ml of the above buffer
and rehomogenized for 2 cycles. The rehomogenized cells are then
centrifuged at 700 RPM (1000.times.g) for 10 minutes and the
supernatant is removed. The combined supernatant (200 ml) is
centrifuged at 23,000 RPM (80,000.times.g) for 1 hour in a Beckman
Rotor (42.1 Ti). The membrane pellet is resupended in 50-8-ml of
assay buffer containing HEPES 20 mM, MgCl2 10 mM, NaCl 150 mM, EDTA
1 mM, pH 7.4 and stored frozen in aliqouts at -70.degree. C.
[0114] 5-HT.sub.6 Receptor Binding Assay
[0115] The radioligand binding assay used [.sup.3H]-lysergic acid
diethylamide (LSD). The assay is carried out in Wallac 96-well
sample plates by the addition of 11 .mu.l of the test sample at the
appropriate dilution (the assay employed 11 serial concentrations
of samples run in duplicate), 11 .mu.l of radioligand, and 178
.mu.l of a washed mixture of WGA-coated SPA beads and membranes in
binding buffer. The plates are shaken for about 5 minutes and then
incubated at room temperature for 1 hour. The plates are then
loaded into counting cassettes and counted in a Wallac MicroBeta
Trilux scintillation counter.
[0116] Binding Constant (Ki) Determination
[0117] Eleven serial dilutions of test compounds are distributed to
assay plates using the PE/Cetus Pro/Pette pipetter. These dilutions
were, followed by radioligand and the bead-membrane mixture
prepared as described above. The specifically bound cpm obtained
are fit to a one-site binding model using GraphPad Prism ver. 2.0.
Estimated IC.sub.50 values are converted to Ki values using the
Cheng-Prusoff equation (Cheng, Y. C. et al., Biochem. Pharmacol.,
22, 3099-108, 1973). The Ki values obtained from the assay are
shown in Table 1.
1TABLE 1 5-HT.sub.6 receptor Binding Assay Data Example # Ki (nM) 1
2.6 2 4.9 3 31 4 32 5 23 6 68 7 3.6 8 5.2 9 79 10 11 11 11 12 1.4
13 2.7 14 --
[0118] The compounds and their preparations of the present
invention will be better understood in connection with the
following examples, which are intended as an illustration of and
not a limitation upon the scope of the invention.
EXAMPLE 1
Preparation of 2-(phenylsulfonyl)-5-(1-piperazinyl)phenylamine
[0119] 6
[0120] Step 1: Preparation of 4-fluoro-2-nitro-1-(phenylsulfanyl)
Benzene
[0121] To a mixture of thiophenol (0.96 mL, 9.3 mmol) and potassium
carbonate (1.4 g, 10.1 mmol) in 16 mL of dry acetonitrile is added
2,5-difluoronitrobenzene (1.0 mL, 9.2 mmol). The mixture is allowed
to stir overnight at rt. Water (30 mL) and CH.sub.2Cl.sub.2 are
added and the layers seperated. The aqueous layer is extracted with
CH.sub.2Cl.sub.2 (3.times.25 mL). The combined organics are dried
over MgSO.sub.4, filtered, and concentrated. Recrystallization from
EtOAc/heptane gives 2.3 g (99%) of the title compound as a solid,
mp 66-67.degree. C.
[0122] IR (drift) 1576, 1526, 1468, 1344, 1286, 1269, 1209, 946,
866, 819, 806, 756, 749, 693, 645 cm.sup.-1; .sup.1H NMR (300 MHz,
CDCl.sub.3) .delta. 7.95, 7.54-7.60, 7.46-7.52, 7.07-7.15, 6.85; MS
(EI) m/z 249 (M.sup.+), 203, 202, 186, 185, 184, 78, 77.
[0123] Step 2: Preparation of 4-fluoro-2-nitro-1-(phenylsulfonyl)
Benzene
[0124] A solution of 3-chloroperoxybenzoic acid (15 g, 87 mmol) in
110 mL of CH.sub.2Cl.sub.2 is slowly added to a mixture of
4-fluoro-2-nitro-1-(phenylsulfanyl) benzene (8.7 g, 35 mmol) and
sodium bicarbonate (7.3 g, 87 mmol) in 260 mL of CH.sub.2Cl.sub.2,
at -78.degree. C. The solution is stirred at -78.degree. C. for 1
h, then warmed to rt and allowed to stir overnight. The mixture is
partitioned between NaHCO.sub.3 (200 mL) and CH.sub.2Cl.sub.2
(3.times.100 mL). The combined organics are dried over MgSO.sub.4,
filtered and concentrated to a white solid. Recrystallization from
EtOAc/heptane gives 9.7 g (99%) of the title compound as a solid,
mp 127-129.degree. C.;
[0125] IR (drift) 1602, 1590, 1551, 1371, 1329, 1318, 1274, 1227,
1161, 1083, 881, 811, 752, 728, 685 cm.sup.-1; .sup.1H NMR (300
MHz, CDCl.sub.3) .delta. 8.37-8.43, 7.92-8.00, 7.43-7.70; MS (EI)
m/z 281 (M.sup.+), 200, 188, 186, 170, 97, 93, 77.
[0126] Step 3: Preparation of 1-[3-nitro-4-(phenylsulfonyl)
phenyl]piperazine
[0127] A solution of 4-fluoro-2-nitro-1-(phenylsulfonyl) benzene
(1.0 g, 3.6 mmol), piperazine (0.37 g, 4.3 mmol), and potassium
carbonate (0.79 g, 5.7 mmol) is stirred in 35 mL of acetonitrile
overnight at reflux. The mixture is cooled to rt and 35 mL of water
and CH.sub.2Cl.sub.2 are added. The layers are separated and the
aqueous layer extracted with CH.sub.2Cl.sub.2 (3.times.35 mL). The
combined organics are dried over MgSO.sub.4, filtered, and
concentrated. Purification via flash column chromatography (15%
MeOH/CH.sub.2Cl.sub.2) gives 1.1 g (92%) of title compound as a
solid, mp 180-182.degree. C.
[0128] IR (drift) 1601, 1536, 1448, 1367, 1358, 1303, 1254, 1153,
1138, 1085, 1022, 774, 750, 724, 688 cm.sup.-1; .sup.1H NMR (300
MHz, CDCl.sub.3) .delta. 8.10, 7.89-7.95, 7.47-7.55, 6.95-7.05,
3.31-3.45, 2.96-3.08, 2.51; MS (EI) m/z 347 (M.sup.+), 305, 275,
258, 152, 118, 77.
[0129] Step 4: Preparation of Tert-Butyl
4-[3-nitro-4-(phenylsulfonyl)phen- yl]-1-piperazinecarboxylate
[0130] To a solution of 1-[3-nitro-4-(phenylsulfonyl)
phenyl]piperazine (1.5 g, 4.3 mmol) and NaOH (0.38 g, 9.5 mmol) in
64 mL of a 1:1 THF:H.sub.2O solvent system is added a solution of
di-tert-butyl dicarbonate (1.0 g, 4.7 mmol) in 5 mL of THF. The
solution is stirred at rt for 16 h. The mixture is neutralized with
6 N HCl and 25 mL of EtOAc is added. The layers are separated and
the aqueous layer is extracted with EtOAc (3.times.25 mL). The
combined organics are dried over MgSO.sub.4, filtered, and
concentrated. Recrystallization from EtOAc/hexane gives 1.7 g (87%)
of the title compound as solid, mp 190-191.degree. C.
[0131] IR (drift) 1690, 1607, 1544, 1415, 1362, 1350, 1322, 1306,
1290, 1243, 1177, 1151, 1138, 748, 688 cm.sup.-1; .sup.1H NMR (300
MHz, CDCl.sub.3) .delta. 8.13, 7.89-7.97, 7.47-7.62, 6.96-7.05,
3.53-3.64, 3.34-3.45, 1.48; MS (EI) m/z 447 (M.sup.+), 305, 275,
258, 152, 91, 77.
[0132] Step 5: Preparation of Tert-Butyl
4-[3-amino-4-(phenylsulfonyl)phen- yl]-1-piperazinecarboxylate
[0133] To a solution of tert-butyl
4-[3-nitro-4-(phenylsulfonyl)phenyl]-1-- piperazinecarboxylate
(0.85 g, 1.8 mmol) in 20 mL of a 4:1 EtOH:THF solvent system is
added Raney nickel (130 mg suspension in EtOH) followed by
hydrazine monohydrate (0.44 mL, 9.1 mmol). The mixture is stired
vigorously for 2 h and then filtered through celite that is
pretreated with water. The filtrate is concentrated, and the
residue crystallized from MeOH/EtOAc/hexane to give 0.76 g (99%) of
the aniline as a white solid, mp 135-137.degree. C.
[0134] IR (drift) 1693, 1602, 1552, 1448, 1420, 1390, 1366, 1306,
1288, 1249, 1224, 1168, 1142, 1097, 736 cm.sup.-1; .sup.1H NMR (300
MHz, CDCl.sub.3) .delta. 7.85-7.93, 7.68, 7.41-7.56, 6.32, 5.98,
5.09, 3.48-3.58, 3.18-3.28, 1.47; MS (EI) m/z 417 (M.sup.+), 361,
317, 275, 167, 91, 77
[0135] Step 6: Preparation of
2-(phenylsulfonyl)-5-(1-piperazinyl)phenylam- ine
[0136] To a solution of tert-butyl
4-[3-amino-4-(phenylsulfonyl)phenyl]-1-- piperazinecarboxylate
(0.68 g, 1.6 mmol) in 18 mL of CH.sub.2Cl.sub.2 at 0.degree. C., is
added trifluoroacetic acid (18 mL). The solution is stirred at
0.degree. C. for 2 h and then concentrated. Methylene chloride (30
mL) and 1 N NaOH (30 mL) are added and the layers seperated. The
aqueous layer is extracted with CH.sub.2Cl.sub.2 (3.times.25 mL)
and the combined organic layers dried over MgSO.sub.4, filtered,
and concentrated to give 0.46 g (89%) of a white solid. The solid
is dissolved in 50 mL of MeOH and HCl/MeOH (5 mL) is added slowly
and stirred under N.sub.2 for 2 min. The solvent is removed under
vacuum to give a white solid. Recrystallization from
MeOH/EtOAc/hexane gives the pure title compound as the hydrogen
chloride salt, mp 165-166.degree. C.
[0137] IR (drift) 3371, 2831, 1600, 1550, 1447, 1304, 1284, 1260,
1225, 1140, 1092, 1034, 736, 688, 602 cm.sup.-1; .sup.1H NMR (300
MHz, CDCl.sub.3) .delta. 7.86-7.94, 7.66, 7.40-7.55, 6.33, 5.98,
5.03, 3.16-3.30, 2.91-3.04, 2.31; MS (EI) m/z 317 (M.sup.+), 276,
275, 91, 77.
EXAMPLE 2
Preparation of 5-(1,4-diazepan-1-yl)-2-[(3-fluorophenyl)
sulfonyl]phenylamine
[0138] 7
[0139] A solution of
1-[4-[(3-fluorophenyl)sulfonyl]-3-nitrophenyl]-1,4-di- azepane
(using the similar procedure as described in EXAMPLE 1, step 3,
0.382 g, 1.10 mmol) and Pd/C (0.0573 g, 15% by wt. of IV) in 35 mL
of a 4:1 EtOH:THF solvent is exposed to hydrogen gas (25 psi) in a
Parr bottle. The pressure of hydrogen is constantly monitored and
kept near 25 psi. After 2 h, the mixture is filtered, the solids
rinsed with MeOH and CH.sub.2Cl.sub.2, and the filtrate
concentrated to give 0.349 g (99%) of a while solid. The HCl salt
is prepared by standard methods to give an off-white solid.
Recrystallization from hot MeOH/EtOAc/hexane gives a nearly
quantitative yield of the title compound as hydrochloride salt, mp
106-108.degree. C.
[0140] IR (drift) 1600, 1550, 1506, 1474, 1458, 1313, 1290, 1270,
1222, 1135, 1085, 727, 691, 678, 651 cm.sup.-1; .sup.1H NMR (300
MHz, CDCl.sub.3) .delta. 7.67-7.71, 7.56-7.63, 7.35-7.47,
7.10-7.23, 6.17, 5.80, 4.95, 3.48-3.59, 3.00, 2.83, 2.11,
1.81-1.92; MS (EI) m/z 349 (M.sup.+), 307, 293, 281, 148.
EXAMPLE 3
Preparation of 2-[(4-fluorophenyl)sulfonyl]-5-(1-piperazinyl)
Phenylamine
[0141] 8
[0142] Following the general procedure of EXAMPLE 2 and making non
critical variations, 2,5-difluoronitrobenzene is converted to the
title compound, mp144-146.degree. C.
[0143] IR (drift) 2924, 2919, 2685, 2676, 2589, 1599, 1552, 1492,
1451, 1286, 1265, 1236, 1141, 1092, 601 cm.sup.-1; .sup.1H NMR (300
MHz, CDCl.sub.3) .delta. 7.83-7.91, 7.64, 7.03-7.12, 6.69-6.74,
6.23-6.30, 3.46, 3.06-3.15, 2.81-2.89; MS (EI) m/z 335 (M.sup.+),
293, 96, 95, 93, 91, 83
EXAMPLE 4
Preparation of
2-[(4-fluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)
Phenylamine
[0144] 9
[0145] Following the general procedure of EXAMPLE 2 and making non
critical variations, the title compound is obtained, mp
85-89.degree. C.
[0146] IR (drift) 2957, 2926, 2850, 2828, 2793, 2714, 1592, 1552,
1492, 1450, 1287, 1238, 1139, 1090, 837 cm.sup.-1; .sup.1H NMR (300
MHz, MeOH-d.sub.4) .delta. 8.30, 7.64-7.75, 7.37, 7.04-7.12,
3.36-3.44, 2.54-2.62, 2.36, 1.67; MS (EI) m/z 349 (M.sup.+), 334,
279, 213, 120, 96, 91.
EXAMPLE 5
Preparation of 2-[(4-methylphenyl)sulfonyl]-5-(1-piperazinyl)
Phenylamine
[0147] 10
[0148] Following the general procedure of EXAMPLE 1 (Steps 1-6) and
making non critical variations, the title compound is obtained, mp
102-106.degree. C.
[0149] IR (drift) 1599, 1551, 1448, 1302, 1282, 1262, 1139, 1092,
812, 728, 705, 680, 671, 667, 657 cm.sup.1; .sup.1H NMR (300 MHz,
CDCl.sub.3) .delta. 7.77, 7.66, 7.20-7.30, 6.31, 5.97, 5.09,
3.17-3.30, 2.93-3.03, 2.37; MS (EI) m/z 331 (M.sup.+), 290, 289,
119, 93, 92, 91, 65, 57, 56.
EXAMPLE 6
Preparation of
2-[(4-methylphenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)
Phenylamine
[0150] 11
[0151] Following the general procedure of EXAMPLE 1 (Steps 1-6) and
making non critical variations, the title compound is obtained, mp
148-151.degree. C.
[0152] IR (drift) 3334, 2954, 2857, 1598, 1552, 1453, 1296, 1288,
1255, 1140, 1095, 833, 759, 708, 654 cm.sup.1; .sup.1H NMR (300
MHz, CDCl.sub.3) .delta. 8.42-8.60, 7.72-7.81, 7.62-7.72,
7.20-7.33, 6.58, 6.20-6.30, 6.00, 5.12, 3.35-3.50, 2.83, 2.60,
2.38; MS (EI) m/z 345 (M.sup.+), 330, 120, 92, 91, 71, 65, 58, 57,
56.
EXAMPLE 7
Preparation of 5-(4-methyl-1-piperazinyl)-2-(phenylsulfonyl)
Phenylamine
[0153] 12
[0154] Following the general procedure of EXAMPLE 2 and making non
critical variations, the title compound is obtained, mp
90-93.degree. C.
[0155] IR (drift) 3458, 3370, 2843, 1601, 1552, 1448, 1289, 1264,
1230, 1140, 1095, 737, 689, 644, 610 cm.sup.-1; .sup.1H NMR (300
MHz, CDCl.sub.3) .delta. 7.87-7.92, 7.71, 7.66, 7.42-7.51, 6.75,
6.33, 5.98, 5.03, 3.27-3.33, 3.25-3.29, 2.56-2.59, 2.48-2.52, 2.36,
2.33; MS (EI) m/z 331 (M.sup.+), 316, 261, 92, 78.
EXAMPLE 8
Preparation of
2-[(3-fluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)
Phenylamine
[0156] 13
[0157] Following the general procedure of EXAMPLE 2 and making non
critical variations, the title compound is obtained, mp
89-92.degree. C.
[0158] IR (drift) 2670, 2580, 2467, 2446, 1601, 1552, 1474, 1451,
1293, 1267, 1222, 1135, 1087, 697, 616 cm.sup.-1; .sup.1H NMR (300
MHz, CDCl.sub.3) .delta. 7.30, 7.11-7.19, 6.82-6.86, 6.68-6.78,
6.38, 6.31, 4.24, 3.20-3.28, 2.55-2.59, 2.36; MS (EI) m/z 349
(M.sup.+), 334, 279, 91, 86.
EXAMPLE 9
Preparation of
5-(1,4-diazepan-1-yl)-2-[(3,4-difluorophenyl)sulfonyl]
Phenylamine
[0159] 14
[0160] Following the general procedure of EXAMPLE 2 and making
non-critical variations, the title compound is obtained.
[0161] MS (EI) m/z 367 (M+), 311, 299, 134, 122, 119, 91, 70, 65,
63, 57.
EXAMPLE 10
Preparation of 5-(1,4-diazepan-1-yl)-2-(phenylsulfonyl)
Phenylamine
[0162] 15
[0163] Following the general procedure of EXAMPLE 2 and making non
critical variations but using
1-[4-[(phenyl)sulfonyl]-3-nitrophenyl]-1,4-- diazepane as a
starting material, the title compound is obtained. MS (FAB) m/z 332
(MH+), 486, 408, 348, 334, 333, 332, 331, 330, 191, 44.
EXAMPLE 11
Preparation of
5-(1,4-diazepan-1-yl)-2-[(3,5-difluorophenyl)sulfonyl]pheny-
lamine
[0164] 16
[0165] Following the general procedure of EXAMPLE 2 and making non
critical variations, the title compound is obtained.
[0166] MS (EI) m/z 367 (M+), 325, 311, 299, 146, 119, 113, 91, 84,
69, 57.
EXAMPLE 12
Preparation of 5-(1,4-diazepan-1-yl)-2-[(3-fluorophenyl)
sulfonyl]-N-methylphenylamine
[0167] 17
[0168] tert-Butyl
4-[3-amino-4-(phenylsulfonyl)phenyl]-5-(1,4-diazepan-1-y-
l)-1-carboxylate (prepared as described in EXAMPLE 1, step 5; 2.3
g, 5.1 mmol) and methyl trifluoromethane sulfonate (0.58 mL, 5.1
mmol) in 54 mL of dry THF is added sodium hydride (0.21 g, 5.1
mmol) in small portions. Upon complete addition, the mixture is
stirred overnight under a blanket of N.sub.2. The solution is
quenched by the addition of 55 mL of NH.sub.4Cl and the layers are
separated. The aqueous layer is extracted with EtOAc (3.times.50
mL). The combined organic layers are dried over MgSO.sub.4,
filtered, and concentrated. Purification via column chromatography
(30% EtOAc/hexane) gives the desired methylaniline. The carbamate
is deprotected following the synthetic route for EXAMPLE 1 (step 6)
to give 0.11 g (6.0% overall) of the title compound as a solid.
Recrystallization from MeOH/EtOAc/hexane gives the pure product as
the HCl salt, mp 153-154.degree. C.
[0169] IR (drift) 2944, 2811, 2734, 2685, 1596, 1560, 1468, 1290,
1270, 1220, 1133, 795, 732, 691, 677 cm.sup.-1; .sup.1H NMR (300
MHz, CDCl.sub.3) .delta. 7.45-7.65, 7.34-7.45, 7.12-7.21,
6.15-6.30, 6.10, 5.72, 3.51-3.60, 3.30-3.44, 3.01, 2.81, 2.27,
1.80-1.91; MS (EI) m/z 363 (M.sup.+), 307, 295, 234, 216, 146, 81,
77.
EXAMPLE 13
Preparation of N-ethyl-2-(phenylsulfonyl)-5-(1-piperazinyl)
Phenylamine
[0170] 18
[0171] Step 1: Preparation of
1-[3-nitro-4-(phenylsulfanyl)phenyl]piperazi- ne
[0172] To a mixture of piperazine (1.0 g, 12 mmol) and potassium
carbonate (2.0 g, 14 mmol) in 80 mL of dry acetonitrile is added
4-fluoro-2-nitro-1-(phenylsulfanyl) benzene (2, EXAMPLE 1, step 1,
2.7 g, 9.5 mmol). The mixture is allowed to stir overnight at rt.
Water and CH.sub.2Cl.sub.2 (80 mL each) are added and the layers
separated. The aqueous layer is extracted with CH.sub.2Cl.sub.2
(3.times.50 mL). The combined organic layers are dried over
MgSO.sub.4, filtered, and concentrated. Purification via column
chromatography (50% EtOAc/hexane) gives 1.6 g (47%) of the title
compound as a red oil.
[0173] IR (drift) 3683, 3020, 2400, 1547, 1521, 1441, 1338, 1295,
1215, 851, 758, 754, 707, 692, 669 cm.sup.-1; .sup.1H NMR (300 MHz,
CDCl.sub.3) .delta. 7.63, 7.35-7.60, 6.90-7.00, 6.81-6.96,
3.16-3.23, 3.02-3.08; MS (EI) m/z 315 (M.sup.+), 273, 243, 226,
184, 139, 84, 77.
[0174] Step 2: Preparation of Tert-Butyl
4-[3-nitro-4-(phenylsulfanyl)phen- yl]-1-piperazinecarboxylate
[0175] To a solution of
1-[3-nitro-4-(phenylsulfanyl)phenyl]piperazine (1.6 g, 4.5 mmol)
and NaOH (0.39 g, 9.8 mmol) in 64 mL of a 1:1 THF:H.sub.2O solvent
system is added a solution of di-tert-butyl dicarbonate (1.1 g, 4.9
mmol) in 5 mL of THF. The solution is stirred at rt for 16 h. The
mixture is made neutral with 6 N HCl and 25 mL of EtOAc is added.
The layers are separated and the aqueous layer is extracted with
EtOAc (3.times.25 mL). The combined organic layers are dried over
MgSO.sub.4, filtered, and concentrated. Purification by column
chromatography (15% EtOAc/hexane) gives 1.7 g (85%) of the title
compound as a oil.
[0176] IR (drift) 3437, 3344, 2976, 1682, 1613, 1595, 1501, 1429,
1365, 1290, 1258, 1221, 165, 1128, 733 cm.sup.-1; .sup.1H NMR (300
MHz, CDCl.sub.3) .delta. 7.66, 7.49-7.57, 7.39-7.47, 6.98, 6.85,
3.56-3.64, 3.13-3.23, 1.50; MS (EI) m/z 415 (M.sup.+), 385, 329,
285, 244, 243, 227, 151.
[0177] Step 3: Prepartion of Tert-Butyl
4-[3-amino-4-(phenylsulfanyl)pheny- l]-1-piperazinecarboxylate
[0178] To a solution of tert-butyl
4-[3-nitro-4-(phenylsulfanyl)phenyl]-1-- piperazinecarboxylate (1.7
g, 3.8 mmol) in 42 mL of a 4:1 EtOH:THF solvent system is added
Raney nickel (260 mg suspension in EtOH) followed by hydrazine
monohydrate (0.92 mL, 19 mmol). The mixture is stirred vigorously
for 2 h and then filtered through celite that is pretreated with
water. The filtrate is concentrated, the residue crystallized from
MeOH/EtOAc/hexane to give 1.5 g (92%) of the aniline as a white
foam.
[0179] IR (drift) 3344, 2976, 1682, 1613, 1595, 1501, 1430, 1365,
1290, 1259, 1221, 1166, 766, 733, 687 cm.sup.-1; .sup.1H NMR (300
MHz, CDCl.sub.3) .delta. 7.34, 7.16-7.24, 7.02-7.11, 6.30-6.41,
4.34, 3.54-3.64, 3.15-3.24, 1.49; MS (EI) m/z 385 (MH.sup.+), 285,
244, 243, 229, 227, 151, 104.
[0180] Step 4: Preparation of Tert-Butyl
4-[3-(acetylamino)-4-(phenylsulfa-
nyl)phenyl]-1-piperazinecarboxylate
[0181] A solution of tert-butyl
4-[3-amino-4-(phenylsulfanyl)phenyl]-1-pip- erazinecarboxylate
(0.69 g, 1.6 mmol) in 7 mL of dry CH.sub.2Cl.sub.2 is cooled to
0.degree. C. Acetyl chloride (0.13 mL, 1.8 mmol),
diisopropylethylamine (0.32 mL, 1.8 mmol), and DMAP (0.020 g, 0.16
mmol) are added and the solution allowed to warm to rt overnight
with stirring. Water and CH.sub.2Cl.sub.2 (10 mL each) are added
and the layers separated. The aqueous layer is extracted with
CH.sub.2Cl.sub.2 (3.times.10 mL) and the combined organic layers
are washed with 1 N HCl, H.sub.2O, and brine. After drying over
MgSO.sub.4, the mixture is filtered and concentrated to give the
crude product. Purification by column chromatography (25%
EtOAc/hexane) gives 0.70 g (99%) of the titel compound as a
oil.
[0182] IR (mull) 1694, 1596, 1582, 1557, 1518, 1440, 1430, 1395,
1294, 1271, 1238, 1179, 1120, 744, 739 cm.sup.-1; .sup.1H NMR (300
MHz, CDCl.sub.3) .delta. 8.22-8.26, 8.20, 7.46, 7.19-7.26,
7.10-7.15, 7.01-7.03, 6.68, 3.56-3.61, 3.25-3.29, 2.05, 1.48; MS
(EI) m/z 427 (M.sup.+), 371, 327, 285, 227, 218, 161, 147, 134.
[0183] Step 5: Preparation of Tert-Butyl
4-[3-(acetylamino)-4-(phenylsulfo-
nyl)phenyl]-1-piperazinecarboxylate
[0184] A mixture of 3-chloroperoxybenzoic acid (1.3 g, 7.7 mmol) in
17 mL of CH.sub.2Cl.sub.2 is added to a mixture of tert-butyl
4-[3-(acetylamino)-4-(phenylsulfanyl)phenyl]-1-piperazinecarboxylate
(1.3 g, 3.1 mmol) and NaHCO.sub.3 (0.65 g, 7.7 mmol) in 36 mL of
CH.sub.2Cl.sub.2, cooled to -78.degree. C. The solution is stirred
at -78.degree. C. for 1 h and then warmed to rt and stirred for 6
additional hours. The mixture is partitioned between NaHCO.sub.3
(50 mL) and CH.sub.2Cl.sub.2 (3.times.50 mL), dried over
MgSO.sub.4, filtered, and concentrated. Purification by column
chromatography (10% MeOH/CH.sub.2Cl.sub.2) gives 0.51 g (36%) of
the pure title compound as a solid, mp 129-130.degree. C.
[0185] IR (drift) 1697, 1592, 1461, 1442, 1418, 1393, 1366, 1287,
1264, 1252, 1174, 1149, 1036, 752, 690 cm.sup.-1; .sup.1H NMR (300
MHz, CDCl.sub.3) .delta. 10.48, 8.70-8.75, 8.26, 7.70, 7.44-7.56,
3.84-4.24, 3.60-3.83, 3.41, 3.08-3.18, 2.11; MS (EI) m/z 459
(M.sup.+), 310, 261, 218, 185, 161, 150, 128, 85, 77.
[0186] Step 6: Preparation of Tert-Butyl
4-[3-(ethylamino)-4-(phenylsulfon-
yl)phenyl]-1-piperazinecarboxylate
[0187] To a mixture of tert-butyl
4-[3-(acetylamino)-4-(phenylsulfonyl)phe-
nyl]-1-piperazinecarboxylate (0.44 g, 0.96 mmol) in 7 mL of dry THF
is added borane-methyl sulfide complex (0.28 mL, 2.8 mmol, 10.0 M).
The mixture is stirred at rt overnight. The reaction is quenched
upon dropwise addition of 10% HCl. Water (3.0 mL) and KOH (2.0 g)
are added, the mixture heated at reflux for 6 h. At that time
methanol (2 mL) is added and the mixture stirred at reflux
overnight. After cooling to rt, the organics are removed under
reduced pressure, the aqueous layer is saturated with NaCl, and
extracted with CH.sub.2Cl.sub.2 (3.times.10 mL). The combined
organic layers are dried over MgSO.sub.4, filtratered, and
concentrated to give the crude product. Purification by column
chromatography (15% EtOAc/hexane) gave 0.18 g (43%) of the pure
title compound as an oil.
[0188] IR (drift) 2970, 1690, 1592, 1561, 1476, 1457, 1430, 1363,
1288, 1243, 1215, 1173, 1128, 993, 743 cm.sup.-1; .sup.1H NMR (300
MHz, CDCl.sub.3) .delta. 7.48-7.55, 7.36-7.46, 7.32, 6.20, 5.96,
5.90, 3.49-3.59, 3.17-3.25, 2.82-3.06, 1.47, 1.05; MS (EI) m/z 445
(M+), 414, 357, 324, 280, 271, 147, 136, 104, 58, 57.
[0189] Step 7: Preparation of
N-ethyl-2-(phenylsulfonyl)-5-(1-piperazinyl)- phenylamine
[0190] To a solution of tert-butyl
4-[3-(ethylamino)-4-(phenylsulfonyl)phe-
nyl]-1-piperazinecarboxylate (0.18 g, 0.40 mmol) in 4.6 mL of
CH.sub.2Cl.sub.2 at 0.degree. C. is added trifluoroacetic acid (4.6
mL). The solution is stirred at 0.degree. C. for 2 h and then
concentrated. Methylene chloride (10 mL) and 1 N NaOH (10 mL) are
added and the layers seperated. The aqueous layer is extracted with
CH.sub.2Cl.sub.2 (3.times.15 mL) and the combined organic layers
are dried over MgSO.sub.4, filtered, and concentrated to give 0.13
g (86%) of a white solid. The solid is dissolved in 25 mL of MeOH
and HCl/MeOH (5 mL) is added slowly. The solvent is removed under
vacuum to give a white solid. Recrystallization from
MeOH/EtOAc/hexane gives the pure title compound as the hydrogen
chloride salt, mp 121-123.degree. C.
[0191] IR (drift) 2957, 2932, 2822, 2778, 2747, 2720, 2692, 1599,
1588, 1566, 1512, 1449, 1440, 1220, 739 cm.sup.-1; .sup.1H NMR (300
MHz, CDCl.sub.3) .delta. 7.36, 7.17-7.25, 7.03-7.12, 6.30, 6.20,
4.77-4.85, 3.22-3.29, 3.11-3.22, 3.03-3.10, 2.00, 1.18; MS (EI) m/z
345 (M.sup.+), 313, 271, 147, 136, 133, 117, 91, 77.
EXAMPLE 14
Preparation of 5-(1,4-diazepan-1-yl)-N-ethyl-2-[(3-fluorophenyl)
Sulfonyl]aniline Hydrochloride
[0192] 19
[0193] Following the general procedure of EXAMPLE 13 (Steps 1-7)
and making non critical variations,
1-[4-fluoro-2-nitro-1-(phenylsulfanyl)]-3- -fluorobenzene (prepared
as described in EXAMPLE 1, step I) is converted to the title
compound, MS (EI) m/z 377 (M+), 321, 310, 309, 135, 131, 119, 117,
83, 77, 69.
EXAMPLE 15
Preparation of
N-[5-(11,4-diazepan-1-yl)-2-[(3-fluorophenyl)sulfonyl]
Phenyl]acetamide and its Methanesulfonate
[0194] 20
[0195] Step 1: Preparation of 4-fluoro-2-nitrophenyl 3-fluorophenyl
Sulfide
[0196] To a mixture of 3-fluorothiophenol (8.36 g, 65.2 mmol) and
potassium carbonate (9.81 g, 71.0 mmol) in 115 mL of dry
acetonitrile is added 2,5-difluoronitrobenzene (7.00 mL, 64.55
mmol). The mixture is allowed to stir at room temperature for 2
hours. Water and CH.sub.2Cl.sub.2 (120 mL each) are added and the
layers separated. The aqueous layer is extracted with
CH.sub.2Cl.sub.2 (3.times.50 mL). The combined organics are dried
over MgSO.sub.4, filtered, and concentrated to give a bright yellow
solid. The solid is triturated with hexane to give 17.1 g (99%) of
the title compound as a bright yellow solid.
[0197] .sup.1H NMR (300 MHz, CDCl.sub.3) .delta. 7.95, 7.41-7.51,
7.33-7.38, 7.26-7.31, 7.12-7.24, 6.91.
[0198] Step 2: Preparation of 4-fluoro-2-nitrophenyl 3-fluorophenyl
Sulfone
[0199] A mixture of 4-fluoro-2-nitrophenyl 3-fluorophenyl sulfide
(17.1 g, 64.1 mmol) in 430 mL of glacial acetic acid is heated to
100.degree. C. and treated with 7.4 mL of a 30% H.sub.2O.sub.2
solution. After stirring for 20 min at 100.degree. C., another 7.4
mL of the H.sub.2O.sub.2 solution is added and the mixture stirred
at 100.degree. C. for an additional 30 min. After cooling to room
temperature, the mixture is diluted with 450 mL of water and the
resulting white solid is filtered. The solids are rinsed with 1 N
NaOH, and water until neutral to litmus, triturated with hexane,
and dried under vacuum to give 18.5 g (96%) of the title compound
as a white solid.
[0200] .sup.1H NMR (300 MHz, CDCl.sub.3) .delta. 8.38-8.43,
7.74-7.77, 7.62-7.66, 7.47-7.60, 7.31-7.48.
[0201] Step 3: Preparation of 4-(1,4-diazepan-1-yl)-2-nitrophenyl
3-fluorophenyl Sulfone
[0202] A mixture of 4-fluoro-2-nitrophenyl 3-fluorophenyl sulfone
(5.00 g, 16.7 mmol), homopiperazine (2.09 g, 20.9 mmol), and
potassium carbonate (3.46 g, 25.1 mmol) in 140 mL of dry
acetonitrile is stirred vigorously for 4 h at 60.degree. C. After
cooling to room temperature, water and CH.sub.2Cl.sub.2 (140 mL
each) are added and the layers separated. The aqueous layer
extracted with CH.sub.2Cl.sub.2 (3.times.50 mL). The combined
organics are dried over MgSO.sub.4, filtered, and concentrated to
give an orange solid. The crude product is triturated with a hot
Et.sub.2O:CH.sub.2Cl.sub.2 mixture (4:1) until solid. Further
trituration with hot EtOAc/hexane gave 6.31 g (99%) of the title
compound as bright yellow solid.
[0203] .sup.1H NMR (300 MHz, CDCl.sub.3) .delta. 8.05, 7.71-7.76,
7.59-7.64, 7.46-7.54, 7.22-7.30, 6.90, 6.83, 3.54-3.70, 3.00-3.07,
2.80-2.88, 1.82-1.94.
[0204] Step 4: Preparation of Tert-Butyl
4-[4-[(3-fluorophenyl)sulfonyl]-3-
-nitrophenyl]-1,4-diazepane-1-carboxylate
[0205] To a mixture of 4-(1,4-diazepan-1-yl)-2-nitrophenyl
3-fluorophenyl sulfone (49.1 g, 129 mmol) and sodium hydroxide
(11.4 g, 286 mmol) in 650 ml of a 1:1 THF:H.sub.2O solvent is
slowly added a mixture of di-tert-butyl dicarbonate (32.4 g, 148
mmol) in 5 ml of THF. The solution is stirred at rt for 16 h. The
mixture is neutralized with 6 N HCl and 200 mL of CH.sub.2Cl.sub.2
is added. The layers are separated and the aqueous layer extracted
with CH.sub.2Cl.sub.2 (3.times.100 mL). The combined organics are
dried over MgSO.sub.4, filtered, and concentrated to give an orange
solid. The crude product is triturated with EtOAc and hexane to
give 60.35 g (99%) of the title compound as a bright yellow
solid.
[0206] .sup.1H NMR (400 MHz, CDCl.sub.3) .delta. 8.12, 7.76-7.80,
7.63-7.67, 7.52-7.58, 7.31-7.34, 6.94-6.97, 6.87-6.92, 3.62-3.75,
3.39-3.45, 3.30-3.35, 1.94-2.03, 1.42, 1.34.
[0207] Step 5: Preparation of Tert-Butyl
4-[3-amino-4-[(3-fluorophenyl)sul-
fonyl]Phenyl]-1,4-diazepane-1-carboxylate
[0208] A mixture of tert-butyl
4-{4-[(3-fluorophenyl)sulfonyl]-3-nitrophen-
yl}-1,4-diazepane-1-carboxylate (58.0 g, 121 mmol) and Pd/C (8.70
g, 15% by wt.) in 1.5 L of a 2:2:1 THF:MeOH:EtOH solvent is exposed
to hydrogen gas (25 psi) in a Parr bottle. The pressure of hydrogen
is constantly monitored and kept near 25 psi. After 16 h, the
mixture is filtered, solids rinsed with MeOH and CH.sub.2Cl.sub.2,
and filtrate concentrated to give a brown solid. The solid is
triturated with EtOAc and hexane to give 53.4 g (98%) of the title
compound as an off white solid.
[0209] .sup.1H NMR (400 MHz, CDCl.sub.3) .delta. 7.72-7.76, 7.64,
7.44-7.51, 7.21-7.27, 6.22-7.26, 5.84-5.87, 5.03-5.09, 3.52-3.63,
3.33-3.38, 3.23-3.29, 1.91-1.99, 1.45, 1.34.
[0210] Step 6: Preparation of Tert-Butyl
4-[3-(acetylamino)-4-[(3-fluoroph-
enyl)sulfonyl]phenyl]-1,4-diazepane-1-carboxylate
[0211] A mixture of tert-butyl
4-[3-amino-4-[(3-fluorophenyl)sulfonyl]phen-
yl]-1,4-diazepane-1-carboxylate (0.29 g, 0.66 mmol) and anhydrous
acetic anhydride (1.0 mL) is stirred at 60.degree. C. for 1 h under
a nitrogen atmosphere. After cooling to rt, 5 mL of toluene is
added and the mixture concentrated. The crude product is triturated
with more toluene then with EtOAc and Et.sub.2O to give 0.31 g
(97%) of the title compound as a white solid.
[0212] .sup.1H NMR (400 MHz, CDCl.sub.3) .delta. 9.50-9.66,
7.78-7.85, 7.67, 7.51-7.54, 7.37-7.45, 7.14-7.19, 6.35-6.44,
3.50-3.58, 3.21-3.27, 3.12-3.17, 2.15, 1.86-1.94, 1.33, 1.28.
[0213] Step 7: Preparation of
N-[5-(1,4-diazepan-1-yl)-2-[(3-fluorophenyl)-
sulfonyl]Phenyl]acetamide Methanesulfonate
[0214] To a mixture of tert-butyl
4-[3-(acetylamino)-4-[(3-fluorophenyl)su-
lfonyl]phenyl]-1,4-diazepane-1-carboxylate (0.508 g, 1.03 mmol) in
20 mL of a 1:1 Et.sub.2O:CH.sub.2Cl.sub.2 solvent is added
anhydrous methanesulfonic acid (0.109 g, 1.14 mmol) and the mixture
is stirred at rt for 2.5 h. Hot Et.sub.2O (10 mL) is added and the
white solid is filtered, rinsed with Et.sub.2O and dried under
vacuum to give 0.497 g (99%) of the title compound as a white
solid.
[0215] .sup.1H NMR (400 MHz, DMSO-d.sub.6) .delta. 9.42, 8.62-8.64,
7.84, 7.64-7.69, 7.50-7.56, 7.18-7.22, 6.77, 3.69-3.74, 3.49-3.55,
3.22-3.28, 3.11-3.18, 2.29, 2.04-2.08, 1.98-2.03.
EXAMPLE 16
Preparation of
5-(1,4-diazepan-1-yl)-N,N-diethyl-2-[(3-fluorophenyl)sulfon-
yl]phenylamine
[0216] 21
[0217] Following the general procedure of EXAMPLE 2 and making non
critical variations, the title compound is obtained.
[0218] MS (CI) m/z 406 (MH.sup.+), 408, 406, 249, 247, 245, 219,
69, 58, 56, 52.
EXAMPLE 17
Preparation of N-[5-(1,4-diazepan-1-yl)-2-(phenylsulfonyl)
phenyl]acetamide
[0219] 22
[0220] Following the general procedure of EXAMPLE 15 and making non
critical variations but using fluorothiophenol as a starting
material, the title compound is obtained.
[0221] HRMS (FAB) calcd for C.sub.19H.sub.23N.sub.3O.sub.3S+H.sub.1
374.1538, found 374.1515.
EXAMPLE 18
Preparation of
N-[2-[(3-fluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1--
yl)phenyl]acetamide.
[0222] 23
[0223] Following the general procedure of EXAMPLE 15 and making non
critical variations, the title compound is obtained.
[0224] HRMS (FAB) calcd for
C.sub.20H.sub.24FN.sub.3O.sub.3S+H.sub.1 406.1600, found
406.1602.
EXAMPLE 19
Preparation of N-[5-(1,4-diazepan-1-yl)-2-[(3-fluorophenyl)
sulfonyl]phenyl]-N-ethylacetamide
[0225] 24
[0226] Following the general procedure of EXAMPLE 15 and making non
critical variations, the title compound is obtained.
[0227] HRMS (FAB) calcd for
C.sub.21H.sub.26FN.sub.3O.sub.3S+H.sub.1 420.1757, found
420.1760.
[0228] Following the general procedure of EXAMPLEs 1-19 and making
non critical variations, the following compounds can be obtained.
Examples of these compounds are:
[0229] (1)
5-(1,4-diazepan-1-yl)-2-[(4-fluorophenyl)sulfonyl]phenylamine,
[0230] (2)
5-(1,4-diazepan-1-yl)-N-methyl-2-(phenylsulfonyl)phenylamine,
[0231] (3)
5-(1,4-diazepan-1-yl)-2-[(4-fluorophenyl)sulfonyl]-N-methylphen-
ylamine,
[0232] (4)
5-(1,4-diazepan-1-yl)-2-[(3,4-difluorophenyl)sulfonyl]-N-methyl-
phenylamine,
[0233] (5)
5-(1,4-diazepan-1-yl)-2-[(3,5-difluorophenyl)sulfonyl]-N-methyl-
phenylamine,
[0234] (6)
5-(1,4-diazepan-1-yl)-N-ethyl-2-(phenylsulfonyl)phenylamine,
[0235] (7)
5-(1,4-diazepan-1-yl)-N-ethyl-2-[(4-fluorophenyl)sulfonyl]pheny-
lamine,
[0236] (8)
5-(1,4-diazepan-1-yl)-N-ethyl-2-[(3,4-difluorophenyl)sulfonyl]p-
henylamine,
[0237] (9)
5-(1,4-diazepan-1-yl)-N-ethyl-2-[(3,5-difluorophenyl)sulfonyl]p-
henylamine,
[0238] (10)
5-(1,4-diazepan-1-yl)-2-(phenylsulfonyl)-N-propylphenylamine,
[0239] (11)
5-(1,4-diazepan-1-yl)-2-[(3-fluorophenyl)sulfonyl]-N-propylphe-
nylamine,
[0240] (12)
5-(1,4-diazepan-1-yl)-2-[(4-fluorophenyl)sulfonyl]-N-propylphe-
nylamine,
[0241] (13)
5-(1,4-diazepan-1-yl)-2-[(3,4-difluorophenyl)sulfonyl]-N-propy-
lphenylamine,
[0242] (14)
5-(1,4-diazepan-1-yl)-2-[(3,5-difluorophenyl)sulfonyl]-N-propy-
lphenylamine,
[0243] (15)
5-(1,4-diazepan-1-yl)-N,N-dimethyl-2-(phenylsulfonyl)phenylami-
ne,
[0244] (16)
5-(1,4-diazepan-1-yl)-2-[(3-fluorophenyl)sulfonyl]-N,N-dimethy-
lphenylamine,
[0245] (17)
5-(1,4-diazepan-1-yl)-2-[(4-fluorophenyl)sulfonyl]-N,N-dimethy-
lphenylamine,
[0246] (18)
5-(1,4-diazepan-1-yl)-2-[(3,4-difluorophenyl)sulfonyl]-N,N-dim-
ethylphenylamine,
[0247] (19)
5-(1,4-diazepan-1-yl)-2-[(3,5-difluorophenyl)sulfonyl]-N,N-dim-
ethylphenylamine,
[0248] (20)
5-(1,4-diazepan-1-yl)-N,N-diethyl-2-(phenylsulfonyl)phenylamin-
e,
[0249] (21)
5-(1,4-diazepan-1-yl)-N,N-diethyl-2-[(4-fluorophenyl)sulfonyl]-
phenylamine,
[0250] (22)
5-(1,4-diazepan-1-yl)-N,N-diethyl-2-[(3,4-difluorophenyl)sulfo-
nyl]phenylamine,
[0251] (23)
5-(1,4-diazepan-1-yl)-N,N-diethyl-2-[(3,5-difluorophenyl)sulfo-
nyl]phenylamine,
[0252] (24)
5-(1,4-diazepan-1-yl)-2-(phenylsulfonyl)-N,N-dipropylphenylami-
ne,
[0253] (25)
5-(1,4-diazepan-1-yl)-2-[(3-fluorophenyl)sulfonyl]-N,N-dipropy-
lphenylamine,
[0254] (26)
5-(1,4-diazepan-1-yl)-2-[(4-fluorophenyl)sulfonyl]-N,N-dipropy-
lphenylamine,
[0255] (27)
5-(1,4-diazepan-1-yl)-2-[(3,4-difluorophenyl)sulfonyl]-N,N-dip-
ropylphenylamine, or
[0256] (28)
5-(1,4-diazepan-1-yl)-2-[(3,5-difluorophenyl)sulfonyl]-N,N-dip-
ropylphenylamine.
[0257] Another examples are:
[0258] (1)
N-[5-(1,4-diazepan-1-yl)-2-[(4-fluorophenyl)sulfonyl]phenyl]ace-
tamide,
[0259] (2)
N-[5-(1,4-diazepan-1-yl)-2-[(3,4-difluorophenyl)sulfonyl]phenyl- ]
acetamide,
[0260] (3)
N-[5-(1,4-diazepan-1-yl)-2-[(3,5-difluorophenyl)sulfonyl]phenyl-
]acetamide,
[0261] (4)
N-[5-(1,4-diazepan-1-yl)-2-(phenylsulfonyl)phenyl]-N-methylacet-
amide,
[0262] (5)
N-{5-(1,4-diazepan-1-yl)-2-[(3-fluorophenyl)sulfonyl]phenyl}-N--
methylacetamide,
[0263] (6)
N-[5-(1,4-diazepan-1-yl)-2-[(4-fluorophenyl)sulfonyl]phenyl]-N--
methylacetamide,
[0264] (7)
N-[5-(1,4-diazepan-1-yl)-2-[(3,4-difluorophenyl)sulfonyl]phenyl-
]-N-methylacetamide,
[0265] (8)
N-[5-(1,4-diazepan-1-yl)-2-[(3,5-difluorophenyl)sulfonyl]phenyl-
]-N-methylacetamide,
[0266] (9)
N-[5-(1,4-diazepan-1-yl)-2-(phenylsulfonyl)phenyl]-N-ethylaceta-
mide,
[0267] (10)
N-[5-(1,4-diazepan-1-yl)-2-[(4-fluorophenyl)sulfonyl]phenyl]-N-
-ethylacetamide,
[0268] (11)
N-[5-(1,4-diazepan-1-yl)-2-[(3,4-difluorophenyl)sulfonyl]pheny-
l]-N-ethylacetamide,
[0269] (12)
N-[5-(1,4-diazepan-1-yl)-2-[(3,5-difluorophenyl)sulfonyl]pheny-
l]-N-ethylacetamide,
[0270] (13)
N-[5-(1,4-diazepan-1-yl)-2-(phenylsulfonyl)phenyl]-N-propylace-
tamide,
[0271] (14)
N-[5-(1,4-diazepan-1-yl)-2-[(3-fluorophenyl)sulfonyl]phenyl]-N-
-propylacetamide,
[0272] (15)
N-[5-(1,4-diazepan-1-yl)-2-[(4-fluorophenyl)sulfonyl]phenyl]-N-
-propylacetamide,
[0273] (16)
N-[5-(1,4-diazepan-1-yl)-2-[(3,4-difluorophenyl)sulfonyl]pheny-
l-N-propylacetamide,
[0274] (17)
N-[5-(1,4-diazepan-1-yl)-2-[(3,5-difluorophenyl)sulfonyl]pheny-
l]-N-propylacetamide,
[0275] (18)
N-[5-(4-methyl-1,4-diazepan-1-yl)-2-(phenylsulfonyl)phenyl]ace-
tamide,
[0276] (19)
N-[2-[(4-fluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-yl)-
phenyl]acetamide,
[0277] (20)
N-[2-[(3,4-difluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-
-yl)phenyl]acetamide,
[0278] (21)
N-[2-[(3,5-difluorophenyl)sulfonyl-5-(4-methyl-1,4-diazepan-1--
yl)phenyl] acetamide,
[0279] (22)
N-methyl-N-[5-(4-methyl-1,4-diazepan-1-yl)-2-(phenylsulfonyl)p-
henyl]acetamide,
[0280] (23)
N-[2-[(3-fluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-yl)-
phenyl]-N-methylacetamide,
[0281] (24)
N-[2-[(4-fluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-yl)-
phenyl]-N-methylacetamide,
[0282] (25)
N-[2-[(3,4-difluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-
-yl)phenyl]-N-methylacetamide,
[0283] (26)
N-[2-[(3,5-difluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-
-yl)phenyl]-N-methylacetamide,
[0284] (27)
N-ethyl-N-[5-(4-methyl-1,4-diazepan-1-yl)-2-(phenylsulfonyl)ph-
enylacetamide,
[0285] (28)
N-ethyl-N-[2-[(3-fluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazep-
an-1-yl)phenyl] acetamide,
[0286] (29)
N-ethyl-N-[2-[(4-fluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazep-
an-1-yl)phenyl] acetamide,
[0287] (30)
N-ethyl-N-[2-[(3,4-difluorophenyl)sulfonyl]-5-(4-methyl-1,4-di-
azepan-1-yl)phenyl] acetamide,
[0288] (31)
N-ethyl-N-[2-[(3,5-difluorophenyl)sulfonyl]-5-(4-methyl-1,4-di-
azepan-1-yl)phenyl]acetamide,
[0289] (32)
N-[5-(4-methyl-1,4-diazepan-1-yl)-2-(phenylsulfonyl)phenyl]-N--
propylacetamide,
[0290] (33)
N-[2-[(3-fluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-yl)-
phenyl]-N-propylacetamide,
[0291] (34)
N-[2-[(4-fluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-yl)-
phenyl]-N-propylacetamide,
[0292] (35)
N-[2-[(3,4-difluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-
-yl)phenyl]-N-propylacetamide,
[0293] (36)
N-[2-[(3,5-difluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-
-yl)phenyl]-N-propylacetamide,
[0294] Another examples are:
[0295] (1)
5-(4-methyl-1,4-diazepan-1-yl)-2-(phenylsulfonyl)phenylamine,
[0296] (2)
2-[(3-fluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-yl)phen-
ylamine,
[0297] (3)
2-[(4-fluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-yl)phen-
ylamine,
[0298] (4)
2-[(3,4-difluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-yl)-
phenylamine,
[0299] (5)
2-[(3,5-difluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-yl)-
phenyl amine,
[0300] (6)
N-methyl-N-[5-(4-methyl-1,4-diazepan-1-yl)-2-(phenylsulfonyl)ph-
enyl]amine,
[0301] (7)
N-[2-[(3-fluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-yl)p-
henyl]-N-methylamine,
[0302] (8)
N-[2-[(4-fluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-yl)p-
henyl]-N-methylamine,
[0303] (9)
N-[2-[(3,4-difluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1--
yl)phenyl]-N-methylamine,
[0304] (10)
N-[2-[(3,5-difluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-
-yl)phenyl]-N-methylamine,
[0305] (11)
N-ethyl-N-[5-(4-methyl-1,4-diazepan-1-yl)-2-(phenylsulfonyl)ph-
enyl]amine,
[0306] (12)
N-ethyl-N-[2-[(3-fluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazep-
an-1-yl)phenyl]amine,
[0307] (13)
N-ethyl-N-[2-[(4-fluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazep-
an-1-yl)phenyl]amine,
[0308] (14)
N-ethyl-N-[2-[(3,4-difluorophenyl)sulfonyl]-5-(4-methyl-1,4-di-
azepan-1-yl)phenyl]amine,
[0309] (15)
N-ethyl-N-[2-[(3,5-difluorophenyl)sulfonyl]-5-(4-methyl-1,4-di-
azepan-1-yl)phenyl]amine,
[0310] (16)
N-[5-(4-methyl-1,4-diazepan-1-yl)-2-(phenylsulfonyl)phenyl]-N--
propylamine,
[0311] (17)
N-[2-[(3-fluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-yl)-
phenyl]-N-propylamine,
[0312] (18)
N-[2-[(4-fluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-yl)-
phenyl]-N-propylamine,
[0313] (19)
N-[2-[(3,4-difluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-
-yl)phenyl]-N-propylamine,
[0314] (20)
N-[2-[(3,5-difluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-
-yl)phenyl]-N-propylamine,
[0315] (21)
N,N-dimethyl-N-[5-(4-methyl-1,4-diazepan-1-yl)-2-(phenylsulfon-
yl)phenyl]amine,
[0316] (22)
N-[2-[(3-fluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-yl)-
phenyl]-N,N-dimethylamine,
[0317] (23)
N-[2-[(4-fluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-yl)-
phenyl]-N,N-dimethylamine,
[0318] (24)
N-[2-[(3,4-difluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-
-yl)phenyl]-N,N-dimethylamine,
[0319] (25)
N-[2-[(3,5-difluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-
-yl)phenyl]-N,N-dimethylamine,
[0320] (26)
N,N-diethyl-N-[5-(4-methyl-1,4-diazepan-1-yl)-2-(phenylsulfony-
l)phenyl]amine,
[0321] (27)
N,N-diethyl-N-[2-[(3-fluorophenyl)sulfonyl]-5-(4-methyl-1,4-di-
azepan-1-yl)phenyl]amine,
[0322] (28)
N,N-diethyl-N-[2-[(4-fluorophenyl)sulfonyl]-5-(4-methyl-1,4-di-
azepan-1-yl)phenyl]amine,
[0323] (29)
N,N-diethyl-N-[2-[(3,4-difluorophenyl)sulfonyl]-5-(4-methyl-1,-
4-diazepan-1-yl)phenyl]amine,
[0324] (30)
N,N-diethyl-N-[2-[(3,5-difluorophenyl)sulfonyl]-5-(4-methyl-1,-
4-diazepan-1-yl)phenyl]amine,
[0325] (31)
N-[5-(4-methyl-1,4-diazepan-1-yl)-2-(phenylsulfonyl)phenyl]-N,-
N-dipropylamine,
[0326] (32)
N-[2-[(3-fluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-yl)-
phenyl]-N,N-dipropylamine,
[0327] (33)
N-[2-[(4-fluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-yl)-
phenyl]-N,N-dipropylamine,
[0328] (34)
N-[2-[(3,4-difluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-
-yl)phenyl]-N,N-dipropylamine, or
[0329] (35)
N-[2-[(3,5-difluorophenyl)sulfonyl]-5-(4-methyl-1,4-diazepan-1-
-yl)phenyl-N,N-dipropylamine.
[0330] Another examples are:
[0331] (1)
2-[(3-fluorophenyl)sulfonyl]-5-(1-piperazinyl)phenylamine,
[0332] (2)
2-[(3,4-difluorophenyl)sulfonyl]-5-(1-piperazinyl)phenylamine,
[0333] (3)
2-[(3,5-difluorophenyl)sulfonyl]-5-(1-piperazinyl)phenylamine,
[0334] (4)
N-methyl-2-(phenylsulfonyl)-5-(1-piperazinyl)phenylamine,
[0335] (5)
2-[(3-fluorophenyl)sulfonyl]-N-methyl-5-(1-piperazinyl)phenylam-
ine,
[0336] (6)
2-[(3,4-difluorophenyl)sulfonyl]-N-methyl-5-(1-piperazinyl)phen-
ylamine,
[0337] (7)
2-[(3,5-difluorophenyl)sulfonyl]-N-methyl-5-(1-piperazinyl)phen-
ylamine,
[0338] (8)
N-ethyl-2-[(4-fluorophenyl)sulfonyl]-5-(1-piperazinyl)phenylami-
ne,
[0339] (9)
N-ethyl-2-[(3,4-difluorophenyl)sulfonyl]-5-(1-piperazinyl)pheny-
lamine,
[0340] (10)
N-ethyl-2-[(3,5-difluorophenyl)sulfonyl]-5-(1-piperazinyl)phen-
ylamine,
[0341] (11)
2-(phenylsulfonyl)-5-(1-piperazinyl)-N-propylphenylamine,
[0342] (12)
2-[(3-fluorophenyl)sulfonyl]-5-(1-piperazinyl)-N-propylphenyla-
mine,
[0343] (13)
2-[(4-fluorophenyl)sulfonyl]-5-(1-piperazinyl)-N-propylphenyla-
mine,
[0344] (14)
2-[(3,4-difluorophenyl)sulfonyl]-5-(1-piperazinyl)-N-propylphe-
nylamine,
[0345] (15)
2-[(3,5-difluorophenyl)sulfonyl]-5-(1-piperazinyl)-N-propylphe-
nylamine,
[0346] (16)
N,N-dimethyl-2-(phenylsulfonyl)-5-(1-piperazinyl)phenylamine,
[0347] (17)
2-[(3-fluorophenyl)sulfonyl]-N,N-dimethyl-5-(1-piperazinyl)phe-
nylamine,
[0348] (18)
2-[(4-fluorophenyl)sulfonyl]-N,N-dimethyl-5-(1-piperazinyl)phe-
nylamine,
[0349] (19)
2-[(3,4-difluorophenyl)sulfonyl]-N,N-dimethyl-5-(1-piperazinyl-
)phenylamine,
[0350] (20)
2-[(3,5-difluorophenyl)sulfonyl]-N,N-dimethyl-5-(1-piperazinyl-
)phenylamine,
[0351] (21) N,N-diethyl-2-(phenylsulfonyl)-5-(1-piperazinyl)phenyl
amine,
[0352] (22)
N,N-diethyl-2-[(3-fluorophenyl)sulfonyl]-5-(1-piperazinyl)phen-
ylamine,
[0353] (23)
N,N-diethyl-2-[(4-fluorophenyl)sulfonyl]-5-(1-piperazinyl)phen-
ylamine,
[0354] (24)
N,N-diethyl-2-[(3,4-difluorophenyl)sulfonyl]-5-(1-piperazinyl)-
phenylamine,
[0355] (25)
N,N-diethyl-2-[(3,5-difluorophenyl)sulfonyl]-5-(1-piperazinyl)-
phenylamine,
[0356] (26)
2-(phenylsulfonyl)-5-(1-piperazinyl)-N,N-dipropylphenylamine,
[0357] (27)
2-[(3-fluorophenyl)sulfonyl]-5-(1-piperazinyl)-N,N-dipropylphe-
nylamine,
[0358] (28)
2-[(4-fluorophenyl)sulfonyl]-5-(1-piperazinyl)-N,N-dipropylphe-
nylamine,
[0359] (29)
2-[(3,4-difluorophenyl)sulfonyl]-5-(1-piperazinyl)-N,N-dipropy-
lphenylamine, or
[0360] (30)
2-[(3,5-difluorophenyl)sulfonyl]-5-(1-piperazinyl)-N,N-dipropy-
lphenylamine.
[0361] Another examples are:
[0362] (1)
N-[2-(phenylsulfonyl)-5-(1-piperazinyl)phenyl]acetamide,
[0363] (2)
N-[2-[(3-fluorophenyl)sulfonyl]-5-(1-piperazinyl)phenyl]acetami-
de,
[0364] (3)
N-[2-[(4-fluorophenyl)sulfonyl]-5-(1-piperazinyl)phenyl]acetami-
de,
[0365] (4)
N-[2-[(3,4-difluorophenyl)sulfonyl]-5-(1-piperazinyl)phenyl]ace-
tamide,
[0366] (5)
N-[2-[(3,5-difluorophenyl)sulfonyl]-5-(1-piperazinyl)phenyl]ace-
tamide,
[0367] (6)
N-methyl-N-[2-(phenylsulfonyl)-5-(1-piperazinyl)phenyl]acetamid-
e,
[0368] (7)
N-[2-[(3-fluorophenyl)sulfonyl]-5-(1-piperazinyl)phenyl]-N-meth-
ylacetamide,
[0369] (8)
N-[2-[(4-fluorophenyl)sulfonyl]-5-(1-piperazinyl)phenyl]-N-meth-
ylacetamide,
[0370] (9)
N-[2-[(3,4-difluorophenyl)sulfonyl]-5-(1-piperazinyl)phenyl]-N--
methylacetamide,
[0371] (10)
N-[2-[(3,5-difluorophenyl)sulfonyl]-5-(1-piperazinyl)phenyl]-N-
-methylacetamide,
[0372] (11)
N-ethyl-N-[2-(phenylsulfonyl)-5-(1-piperazinyl)phenyl]acetamid-
e,
[0373] (12)
N-ethyl-N-[2-[(3-fluorophenyl)sulfonyl]-5-(1-piperazinyl)pheny-
l]acetamide,
[0374] (13)
N-ethyl-N-[2-[(4-fluorophenyl)sulfonyl]-5-(1-piperazinyl)pheny-
l]acetamide,
[0375] (14)
N-ethyl-N-[2-[(3,4-difluorophenyl)sulfonyl]-5-(1-piperazinyl)p-
henyl]acetamide,
[0376] (15)
N-ethyl-N-[2-[(3,5-difluorophenyl)sulfonyl]-5-(1-piperazinyl)p-
henyl]acetamide,
[0377] (16)
N-[2-(phenylsulfonyl)-5-(1-piperazinyl)phenyl]-N-propylacetami-
de,
[0378] (17)
N-[2-[(3-fluorophenyl)sulfonyl]-5-(1-piperazinyl)phenyl]-N-pro-
pylacetamide,
[0379] (18)
N-[2-[(4-fluorophenyl)sulfonyl]-5-(1-piperazinyl)phenyl]-N-pro-
pylacetamide,
[0380] (19)
N-[2-[(3,4-difluorophenyl)sulfonyl]-5-(1-piperazinyl)phenyl]-N-
-propylacetamide,
[0381] (20)
N-[2-[(3,5-difluorophenyl)sulfonyl]-5-(1-piperazinyl)phenyl]-N-
-propylacetamide,
[0382] (21)
N-[5-(4-methyl-1-piperazinyl)-2-(phenylsulfonyl)phenyl]acetami-
de,
[0383] (22)
N-[2-[(3-fluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)phen-
yl]acetamide,
[0384] (23)
N-[2-[(4-fluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)phen-
yl]acetamide,
[0385] (24)
N-[2-[(3,4-difluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)-
phenyl]acetamide,
[0386] (25)
N-[2-[(3,5-difluorophenyl)sulfonyl-5-(4-methyl-1-piperazinyl)p-
henyl] acetamide,
[0387] (26)
N-methyl-N-[5-(4-methyl-1-piperazinyl)-2-(phenylsulfonyl)pheny-
l]acetamide,
[0388] (27)
N-[2-[(3-fluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)phen-
yl]-N-methylacetamide,
[0389] (28)
N-[2-[(4-fluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)phen-
yl]-N-methylacetamide,
[0390] (29)
N-[2-[(3,4-difluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)-
phenyl]-N-methylacetamide,
[0391] (30)
N-[2-[(3,5-difluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)-
phenyl]-N-methylacetamide,
[0392] (31)
N-ethyl-N-[5-(4-methyl-1-piperazinyl)-2-(phenylsulfonyl)phenyl-
]acetamide,
[0393] (32)
N-ethyl-N-[2-[(3-fluorophenyl)sulfonyl]-5-(4-methyl-1-piperazi-
nyl)phenyl]acetamide,
[0394] (33)
N-ethyl-N-[2-[(4-fluorophenyl)sulfonyl]-5-(4-methyl-1-piperazi-
nyl)phenyl]acetamide,
[0395] (34)
N-ethyl-N-[2-[(3,4-difluorophenyl)sulfonyl]-5-(4-methyl-1-pipe-
razinyl)phenyl]-N-ethyl acetamide,
[0396] (35)
N-ethyl-N-[2-[(3,5-difluorophenyl)sulfonyl]-5-(4-methyl-1-(36)
piperazinyl)phenyl] acetamide,
[0397] (36)
N-[5-(4-methyl-1-piperazinyl)-2-(phenylsulfonyl)phenyl]-N-prop-
ylacetamide,
[0398] (37)
N-[2-[(3-fluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)phen-
yl]-N-propylacetamide,
[0399] (38)
N-[2-[(4-fluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)phen-
yl]-N-propylacetamide,
[0400] (39)
N-[2-[(3,4-difluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)-
phenyl]-N-propylacetamide, or
[0401] (40)
N-[2-[(3,5-difluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)-
phenyl]-N-propylacetamide.
[0402] Another examples are:
[0403] (1)
2-[(3,4-difluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)phen-
ylamine,
[0404] (2)
2-[(3,5-difluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)phen-
ylamine,
[0405] (3)
N-methyl-N-[5-(4-methyl-1-piperazinyl)-2-(phenylsulfonyl)phenyl-
]amine,
[0406] (4)
N-[2-[(3-fluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)pheny-
l]-N-methylamine,
[0407] (5)
N-[2-[(4-fluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)pheny-
l]-N-methylamine,
[0408] (6)
N-[2-[(3,4-difluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)p-
henyl]-N-methylamine,
[0409] (7)
N-[2-[(3,5-difluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)p-
henyl]-N-methylamine,
[0410] (8)
N-ethyl-N-[5-(4-methyl-1-piperazinyl)-2-(phenylsulfonyl)phenyl]-
amine,
[0411] (9)
N-ethyl-N-[2-[(3-fluorophenyl)sulfonyl]-5-(4-methyl-1-piperazin-
yl)phenyl]amine,
[0412] (10)
N-ethyl-N-[2-[(4-fluorophenyl)sulfonyl]-5-(4-methyl-1-piperazi-
nyl)phenyl]amine,
[0413] (11)
N-ethyl-N-[2-[(3,4-difluorophenyl)sulfonyl]-5-(4-methyl-1-pipe-
razinyl)phenyl]amine,
[0414] (12)
N-ethyl-N-[2-[(3,5-difluorophenyl)sulfonyl]-5-(4-methyl-1-pipe-
razinyl)phenyl]amine,
[0415] (13)
N-[5-(4-methyl-1-piperazinyl)-2-(phenylsulfonyl)phenyl]-N-prop-
ylamine,
[0416] (14)
N-[2-[(3-fluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)phen-
yl]-N-propylamine,
[0417] (15)
N-[2-[(4-fluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)phen-
yl]-N-propylamine,
[0418] (16)
N-[2-[(3,4-difluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)-
phenyl]-N-propylamine,
[0419] (17)
N-[2-[(3,5-difluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)-
phenyl]-N-propylamine,
[0420] (18)
N,N-dimethyl-N-[5-(4-methyl-1-piperazinyl)-2-(phenylsulfonyl)p-
henyl]amine,
[0421] (19)
N-[2-[(3-fluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)phen-
yl]-N,N-dimethylamine,
[0422] (20)
N-[2-[(4-fluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)phen-
yl]-N,N-dimethylamine,
[0423] (21)
N-[2-[(3,4-difluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)-
phenyl]-N,N-dimethylamine,
[0424] (22)
N-[2-[(3,5-difluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)-
phenyl]-N,N-dimethylamine,
[0425] (23)
N,N-diethyl-N-[5-(4-methyl-1-piperazinyl)-2-(phenylsulfonyl)ph-
enyl]amine,
[0426] (24)
N,N-diethyl-N-[2-[(3-fluorophenyl)sulfonyl]-5-(4-methyl-1-pipe-
razinyl)phenyl]amine,
[0427] (25)
N,N-diethyl-N-[2-[(4-fluorophenyl)sulfonyl]-5-(4-methyl-1-pipe-
razinyl)phenyl]amine,
[0428] (26)
N,N-diethyl-N-[2-[(3,4-difluorophenyl)sulfonyl]-5-(4-methyl-1--
piperazinyl)phenyl]amine,
[0429] (27)
N,N-diethyl-N-[2-[(3,5-difluorophenyl)sulfonyl]-5-(4-methyl-1--
piperazinyl)phenyl]amine,
[0430] (28)
N-[5-(4-methyl-1-piperazinyl)-2-(phenylsulfonyl)phenyl]-N
N-dipropylamine,
[0431] (29)
N-[2-[(3-fluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)phen-
yl]-N,N-dipropylamine,
[0432] (30)
N-[2-[(4-fluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)phen-
yl]-N,N-dipropylamine,
[0433] (31)
N-[2-[(3,4-difluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)-
phenyl]-N,N-dipropylamine, or
[0434] (32)
N-[2-[(3,5-difluorophenyl)sulfonyl]-5-(4-methyl-1-piperazinyl)-
phenyl-N,N-dipropylamine.
* * * * *