U.S. patent application number 10/320981 was filed with the patent office on 2003-07-03 for versatile vial and plug system.
Invention is credited to Finneran, James G..
Application Number | 20030121878 10/320981 |
Document ID | / |
Family ID | 32965289 |
Filed Date | 2003-07-03 |
United States Patent
Application |
20030121878 |
Kind Code |
A1 |
Finneran, James G. |
July 3, 2003 |
Versatile vial and plug system
Abstract
A versatile vial and plug combination forming a securely sealed
closure of the vial. The combination includes a vial with (a) a
head with an inner diameter (ID) and an outer diameter (OD); (b) a
body with an ID and an OD substantially equal to those of the head;
and (c) a neck having an ID less than the ID, and an OD less than
the OD, of the head and body, providing a recessed robotic arm pick
up area adapted for engagement by automatic equipment. The
combination also includes a resilient plug with (a) an inwardly
tapered base, (b) a top flange, and (c) a body having an OD that
corresponds to or is only slightly greater than the ID of the vial,
assuring an interference fit between the plug and the vial, thereby
sealing the plug inside the vial upon insertion of the plug in the
vial.
Inventors: |
Finneran, James G.;
(Vineland, NJ) |
Correspondence
Address: |
RATNERPRESTIA
P O BOX 980
VALLEY FORGE
PA
19482-0980
US
|
Family ID: |
32965289 |
Appl. No.: |
10/320981 |
Filed: |
December 17, 2002 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
|
|
60343760 |
Dec 27, 2001 |
|
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|
Current U.S.
Class: |
215/247 ;
215/248; 215/355 |
Current CPC
Class: |
B01L 2300/042 20130101;
B65D 39/0023 20130101; B01L 2300/0858 20130101; B65D 39/04
20130101; G01N 30/24 20130101; B01L 2300/044 20130101; B01L 3/5082
20130101; B01L 2300/0681 20130101; A61J 1/1406 20130101; B01L
3/50825 20130101 |
Class at
Publication: |
215/247 ;
215/248; 215/355 |
International
Class: |
B65D 039/00 |
Claims
What is claimed:
1. A versatile vial and plug combination adapted to form a securely
sealed closure of the vial, the combination comprising: a vial
having: (a) a head defining a first chamber with a first inner
diameter and a first outer diameter and extending between a top,
with a center opening, and a lower shoulder, (b) a body defining a
second chamber with a second inner diameter substantially equal to
the first inner diameter and a second outer diameter substantially
equal to the first outer diameter and extending between a base and
an upper shoulder, and (c) a neck having an inner diameter less
than the first inner diameter and an outer diameter less than the
first outer diameter and extending between the lower shoulder of
the head and the upper shoulder of the body, providing a recessed
robotic arm pick up area adapted for engagement by automatic
equipment; and a resilient plug having: (a) a base, (b) a top
flange, and (c) a body extending from the base to the top flange
and having an outer diameter that corresponds to or is only
slightly greater than the first inner diameter of the vial,
assuring an interference fit between the plug and the vial, thereby
sealing the plug inside the vial upon insertion of the plug in the
vial.
2. The versatile vial and plug combination as recited in claim 1
further comprising a filter adapted for insertion into the vial
before insertion of the plug in the vial.
3. The versatile vial and plug combination as recited in claim 1
wherein multiple interference contacts exist between the body of
the plug and the vial upon insertion of the plug in the vial.
4. The versatile vial and plug combination as recited in claim 1
wherein the base of the plug is tapered inwardly to facilitate
insertion of the plug in the vial.
5. The versatile vial and plug combination as recited in claim 1
wherein the body of the plug has an outward angular taper.
6. The versatile vial and plug combination as recited in claim 1
wherein the plug has a button made of a material that can be
pierced by an instrument and resealed after removal of the
instrument.
7. The versatile vial and plug combination as recited in claim 1
wherein the plug has a button with a slit permitting the plug to be
pierced by an instrument and resealed after removal of the
instrument.
8. The versatile vial and plug combination as recited in claim 1
wherein the flange of the plug has an underside contacting the top
of the head of the vial when the plug is fully inserted into the
vial.
9. The versatile vial and plug combination as recited in claim 1
wherein the head has a protrusion adjacent the top, the protrusion
facilitating retention of the plug in the vial upon insertion of
the plug into the vial.
10. The versatile vial and plug combination as recited in claim 1
wherein a first transition exists between the lower shoulder and
the neck and a second transition exists between the neck and the
upper shoulder, the transitions being formed by sharp angles.
11. The versatile vial and plug combination as recited in claim 1
wherein a first curved transition exists between the lower shoulder
and the neck and a second curved transition exists between the neck
and the upper shoulder.
12. The versatile vial and plug combination as recited in claim 1
wherein the vial is one of plastic or glass.
13. The versatile vial and plug combination as recited in claim 1
wherein the resilient plug is made of a material selected from the
group consisting of rubber and plastic.
14. The versatile vial and plug combination as recited in claim 13
wherein the resilient plug is also made of
polytetrafluoroethylene.
15. A versatile vial and plug combination adapted to form a
securely sealed closure of the vial, the combination comprising: a
vial having: (a) a head defining a first chamber with a first inner
diameter and a first outer diameter and extending between a top,
with a center opening, and a lower shoulder, the head having a
protrusion adjacent the top which facilitates retention of the plug
in the vial upon insertion of the plug into the vial, (b) a body
defining a second chamber with a second inner diameter
substantially equal to the first inner diameter and a second outer
diameter substantially equal to the first outer diameter and
extending between a base and an upper shoulder, and (c) a neck
having an inner diameter less than the first inner diameter and an
outer diameter less than the first outer diameter and extending
between the lower shoulder of the head and the upper shoulder of
the body, providing a recessed robotic arm pick up area adapted for
engagement by automatic equipment; and a resilient plug having: (a)
a base tapered inwardly to facilitate insertion of the plug in the
vial, (b) a top flange having an underside contacting the top of
the head of the vial when the plug is fully inserted into the vial,
(c) an outward angular tapered body extending from the base to the
top flange and having an outer diameter that corresponds to or is
only slightly greater than the first inner diameter of the vial,
assuring an interference fit between the plug and the vial, thereby
sealing the plug inside the vial upon insertion of the plug in the
vial, and (d) a button that (i) is made of a material which can be
pierced by an instrument and resealed after removal of the
instrument, or (ii) has a slit permitting the plug to be pierced by
an instrument and resealed after removal of the instrument, wherein
multiple interference contacts exist between the body of the plug
and the vial upon insertion of the plug in the vial.
16. The versatile vial and plug combination as recited in claim 15
further comprising a filter adapted for insertion into the vial
before insertion of the plug in the vial.
17. The versatile vial and plug combination as recited in claim 15
wherein a first transition exists between the lower shoulder and
the neck and a second transition exists between the neck and the
upper shoulder, the transitions being formed by (i) sharp angles,
or (ii) curves.
18. The versatile vial and plug combination as recited in claim 15
wherein the vial is one of plastic or glass.
19. The versatile vial and plug combination as recited in claim 15
wherein the resilient plug is made of a material selected from the
group consisting of rubber and plastic.
20. The versatile vial and plug combination as recited in claim 19
wherein the resilient plug is also made of polytetrafluoroethylene.
Description
CROSS REFERENCE TO RELATED APPLICATION
[0001] This application claims the benefit under Title 35 U.S.C.
.sctn.119(e) of U.S. Provisional Application No. 60/343,760, filed
on Dec. 27, 2001, the contents of which are incorporated by
reference.
TECHNICAL FIELD
[0002] The present invention relates generally to vial and closure
systems and, more particularly, to those systems used in laboratory
analytical techniques. Typically, these types of systems require a
securely sealed closure or cap having a penetrable segment for
introduction or withdrawal of material to or from a vial or
container on which the cap is mounted. Such systems also require
robotic engagement of the vial.
BACKGROUND OF THE INVENTION
[0003] Chromatograghy is a laboratory technique for the separation
and identification of chemical compounds in complex mixtures.
Basically, it involves the flow of a mobile (gas or liquid) phase
over a stationary phase (which may be a solid or a liquid). Liquid
chromatograghy is used for soluble substances and gas (vapor phase)
chromatograghy for volatile substances. As the mobile phase moves
past the stationary phase, repeated adsorption and desorption of
the solute occurs at a rate determined chiefly by its ratio of
distribution between the two phases. If the ratio is large enough,
the components of the mixture will move at different rates,
producing a characteristic pattern, or chromatogragh, from which
their identity can be determined.
[0004] A wide variety of vial and closure systems presently are in
use in the chromatograghy market. Most of them require a
combination of liners and closures for sealing. All known systems
that are used in robotic handling instruments have restricted vial
openings: the top opening inner diameter (or "ID") is smaller than
the ID of the main body of the vial. Examples of such systems are
illustrated in a brochure titled "Chromatograghy Products Profile"
available since 1998 from J. G. Finneran Associates, Inc. of
Vineland, N.J.
[0005] Many conventional containers have a standard snap cap and
neck finish. In this basic snap cap design, the extended skirt of
the cap secures under a protrusion on the neck of the vial upon
sealing the container. The protrusion on the neck of conventional
vials is of increased mass, therefore dimensional tolerance is not
closely controlled during the molding process. Furthermore, the
basic snap cap design does not allow for secure retention of the
cap and the vial. Also, the conventional design of the snap cap
does not provide for ease of assembling the cap and the vial or for
ease of removing the cap from the vial. The snap cap requires the
use of downward pressure to apply the cap and upward pressure to
remove the cap. Such pressure typically is exerted by the thumb of
the user. Advantageously, a snap is heard or felt when the cap is
positioned and the container is sealed. No tools are required
either to apply or to remove the cap.
[0006] The snap cap and container are typically made of plastic.
This is advantageous because metal is undesirable in laboratory
settings. The seal is consistent and provides an adequate
short-term (about 8 hours) seal against solvent evaporation.
Because the materials used to form the cap and container are not
very rigid, however, the designs cannot provide a seal able to
withstand contents under high pressure or provide for long-term
storage without leakage. The characteristics of the snap cap design
have limited use of that design in the chromatograghy market.
[0007] Instead, three other conventional vial and closure systems
are more commonly found in use in the chromatograghy market. The
first system 100B includes a crimp cap 102B and a vial 104B as
illustrated in FIG. 1B. The crimp cap 102B is securely retained on
the neck finish 106B of the (usually glass) vial 104B by crimping a
metallic (usually aluminum) skirt 108B under a lip 110B on the neck
of the vial 104B. One advantage of the aluminum crimp cap 102B is
that it works on containers having either a standard crimp seal or
a snap ring. Another advantage is that the neck finish 106B of the
vial 104B has a robotic arm pick up area 120B adapted for
engagement by automatic equipment. A disadvantage is that the ID of
the vial 104B at its top is relatively small, rendering it somewhat
difficult to fill the vial 104B using, for example and as
illustrated in FIG. 2B, a pipette 150. Another disadvantage is that
the aluminum crimp cap 102B requires the use of a crimping tool to
form a seal. The seal is subject to the amount of squeeze and
alignment given by the user. When properly applied, however, the
aluminum crimp cap 102B provides a good seal against solvent
evaporation.
[0008] Still another common closure system 100C for containers
involves a standard screw thread neck finish 106C on a threaded
vial 104C and a corresponding screw thread on a threaded cap 102C.
Closure is attained and a seal obtained by twisting or rotating the
threaded cap 102C onto the threads 108C of threaded vial 104C, as
illustrated in FIG. 1C. Thus, screw thread closures require finger
torque pressure to apply and remove the threaded cap 102C. The seal
is subject to the amount of torque applied by the user. When
torqued properly, the threaded cap 102C provides a good seal
although not equivalent to the aluminum crimp seal. The neck finish
106C of the threaded vial 104C has a robotic arm pick up area 120C
adapted for engagement by automatic equipment. One drawback is,
however, that the threaded cap 102C can lose torque upon relaxation
of the plastic material, from which the typical threaded cap 102C
is made, which allows the threaded cap 102C to back off the screw
thread 108C. In addition, the threaded cap 102C can only be used on
threaded vials 104C. Like the standard crimp vial 104B, a
disadvantage is that the ID of the threaded vial 104C at its top is
relatively small, rendering it somewhat difficult to fill the vial
using, for example and as illustrated in FIG. 2C, a pipette
150.
[0009] A vial and closure system 100D especially well adapted for
use in the chromatograghy market is the combination of a plastic or
glass shell vial 104D and a plastic plug 102D. As illustrated in
FIG. 1D, the shell vial 104D is a simple cylindrical shell, having
a substantially constant ID and OD along its entire length. This
configuration offers advantages and disadvantages. Unfortunately,
the shell vial 104D is not adapted for engagement by automatic
equipment; it does not have a robotic arm pick up area. On the
other hand, the ID of the top opening of the shell vial 104D is
relatively large, facilitating the process of filling the shell
vial 104D using, for example and as illustrated in FIG. 2D, a
pipette 150. The shell vial 104D is also sealed easily and
effectively by pushing the plug 102D into the top opening of the
shell vial 104D.
[0010] To overcome the shortcomings of the conventional vial and
closure systems used in the chromatograghy market, a new system is
provided. An object of the present invention is to provide a
versatile vial and plug system. A related object is to provide a
vial and closure system that can function with robotic analytical
instruments. Another object is to provide a system having
relatively easy filling (pipetting), filtering, and capping
characteristics.
SUMMARY OF THE INVENTION
[0011] To achieve these and other objects, and in view of its
purposes, the present invention provides a versatile vial and plug
combination adapted to form a securely sealed closure of the vial.
The combination includes a vial with (a) a head defining a first
chamber with a first inner diameter and a first outer diameter and
extending between a top, with a center opening, and a lower
shoulder, (b) a body defining a second chamber with a second inner
diameter substantially equal to the first inner diameter and a
second outer diameter substantially equal to the first outer
diameter and extending between a base and an upper shoulder, and
(c) a neck having an inner diameter less than the first inner
diameter and an outer diameter less than the first outer diameter
and extending between the lower shoulder of the head and the upper
shoulder of the body, providing a recessed robotic arm pick up area
adapted for engagement by automatic equipment. The combination also
includes a resilient plug with (a) an inwardly tapered base, (b) a
top flange, and (c) a body extending from the base to the top
flange and having an outer diameter that corresponds to or is only
slightly greater than the first inner diameter of the vial,
assuring an interference fit between the plug and the vial, thereby
sealing the plug inside the vial upon insertion of the plug in the
vial.
[0012] It is to be understood that both the foregoing general
description and the following detailed description are exemplary,
but are not restrictive, of the invention.
BRIEF DESCRIPTION OF THE DRAWING
[0013] The invention is best understood from the following detailed
description when read in connection with the accompanying drawing.
It is emphasized that, according to common practice, the various
features of the drawing are not to scale. On the contrary, the
dimensions of the various features are arbitrarily expanded or
reduced for clarity. Included in the drawing are the following
figures:
[0014] FIG. 1A illustrates a vial and plug combination in
accordance with the present invention;
[0015] FIG. 1B illustrates a conventional crimp vial with its seal
in place;
[0016] FIG. 1C illustrates a conventional threaded vial with its
closure in place;
[0017] FIG. 1D illustrates a conventional shell vial with its plug
in place;
[0018] FIG. 2A illustrates the vial shown in FIG. 1A with the plug
removed and as the vial is being filled using a pipette;
[0019] FIG. 2B illustrates the crimp vial shown in FIG. 1B with the
seal removed and as the vial is being filled using a pipette;
[0020] FIG. 2C illustrates the threaded vial shown in FIG. 1C with
the closure removed and as the vial is being filled using a
pipette;
[0021] FIG. 2D illustrates the shell vial shown in FIG. 1D with the
plug removed and as the vial is being filled using a pipette;
[0022] FIG. 3 is an expanded view of the vial and plug combination
shown in FIG. 1A, with the plug illustrated in side view and
separated from the vial illustrated in perspective view;
[0023] FIG. 4 is a top view of the vial illustrated in FIG. 3;
[0024] FIG. 5 is a cross-sectional view of the vial shown in FIG.
3, taken along the line 5-5 of FIG. 4;
[0025] FIG. 6 is a side view of the vial shown in FIG. 3;
[0026] FIG. 7 is a top view of the plug illustrated in FIG. 3;
[0027] FIG. 8 is a cross-sectional view of the plug shown in FIG.
3, taken along the line 8-8 of FIG. 7;
[0028] FIG. 9 is a side view of the plug shown in FIG. 3;
[0029] FIG. 10A illustrates a tubular filter upon insertion into
the vial of the present invention having an unfiltered
solution;
[0030] FIG. 10B illustrates the tubular filter shown in FIG. 10A in
place within the vial as sealed by the plug of the present
invention, yielding a filtered solution;
[0031] FIG. 11A illustrates a hollow tubular filter upon insertion
into the vial of the present invention having an unfiltered
solution; and
[0032] FIG. 11B illustrates the hollow tubular filter shown in FIG.
11A in place within the vial as sealed by the plug of the present
invention, yielding a filtered solution.
DETAILED DESCRIPTION OF THE INVENTION
[0033] Referring now to the drawing, in which like reference
numbers refer to like elements throughout, FIG. 3 shows the vial
and plug combination 50 in accordance with the present invention.
Vial and plug combination 50 includes a vial 10 and a resilient
plug 30 having an axis, a. Vial 10 may be plastic or glass. Plug 30
is a resilient plastic.
[0034] Now referring to details of vial 10 as better seen in FIGS.
4-6, vial 10 has three (typically integral or monolithic) sections:
a head 12 defining a first chamber, a body 16 defining a second
chamber, and a neck 14 disposed between head 12 and body 16. Head
12 extends between a top 18, with a center opening 20, and a lower
shoulder 22. Body 16 extends between a base 24 and an upper
shoulder 26.
[0035] In one example embodiment, the walls of vial 10 are about
0.084 cm (0.033 inches) thick. The total length of vial 10 between
base 24 and top 18 is about 3.188 cm (1.255 inches). The length of
head 12, the distance between lower shoulder 22 and top 18, is
about 0.533 cm (0.210 inches). The distance between upper shoulder
26 and top 18 is about 1.031 cm (0.406 inches).
[0036] The ID and outer diameter (or "OD") of the chambers defined
by head 12 and body 16 are substantially equal. In the exemplary
embodiment, the ID is about 0.965 cm (0.380 inches) and the OD is
about 1.160 cm (0.457 inches). Neck 14 extends between lower
shoulder 22 of head 12 and upper shoulder 26 of body 16, providing
a recessed robotic arm pick up area 90 adapted for engagement by
automatic equipment. This robotic arm pick up area 90 is
highlighted in FIG. 1A. The ID and OD of neck 14 are substantially
less than the ID and OD common to head 12 and body 16. In the
exemplary embodiment, the OD of neck 14 is about 0.856 cm (0.337
inches).
[0037] In the embodiment of vial 10 shown in FIG. 1A, lower
shoulder 22 and upper shoulder 26 are defined by sharp angles. It
may be advantageous, however, to round those angles. Therefore, the
alternative embodiment shown in FIGS. 5 and 6 illustrates vial 10
having curved transitions between lower shoulder 22 of head 12 and
neck 14 and between neck 14 and upper shoulder 26 of body 16.
[0038] Head 12 has a protrusion 80 adjacent top 18. In the
exemplary embodiment, the length of protrusion 80 is about 0.079 cm
(0.031 inches). Protrusion 80 functions to form a catch or
undercut, facilitating retention of plug 30 in vial 10.
[0039] The relatively large ID of head 12, defined by the diameter
of center opening 20 and the first chamber, in comparison to
conventional vials, permits the user to fill vial 10 easily. Such
filling is typically done using a pipette, as shown in FIG. 2A.
This characteristic of vial 10 offers a major advantage over
conventional vials, especially those used in chromatograghy
applications.
[0040] As illustrated in FIG. 3, plug 30 has three (typically
integral or monolithic) sections: a top flange 32, a body 34, and
an inwardly tapered base 36. Plug 30 may be made of silicone
rubber, butyl rubber, natural rubber or any other resilient
material which can be used as molded or bonded to an inert material
such as polytetrafluoroethylene (sold under the trademark Teflon of
E. I. DuPont deNemours & Co., Inc. of Wilmington, Del.).
Polytetrafluoroethylene is "a highly stable thermoplastic
tetrafluoroethylene homopolymer composed of at least
20,000C.sub.2F.sub.4 monomer units linked into very long unbranched
chains." Merck Index at 7560.
[0041] Now referring to details of plug 30 as best seen in FIGS.
7-9, top flange 32 of plug 30 has an underside 44 and a central
opening 38 in which is disposed a central, upraised button 40.
Button 40 can be pierced with an instrument needle and reseal
itself after retraction of the needle. In fact, plug 30 assures
excellent resealability of vial and plug combination 50 after
multiple needle penetrations. Button 40 can be provided with a slit
42 (preferably, but not essentially, an X-shaped slit) which
permits plug 30 to be easily pierced with thin-walled instrument
needles.
[0042] The taper of base 36 facilitates insertion of plug 30 into
center opening 20 of vial 10. Thus, at its bottom, base 36 has an
OD which is less than the ID of head 12 of vial 10. Body 34, the OD
of which corresponds to or is only slightly greater than the ID of
head 12 of vial 10, extends vertically upward from base 36 to top
flange 32 and facilitates alignment of plug 30 and vial 10, as they
are assembled. Although the OD of body 34 might be constant (i.e.,
body 34 may be substantially vertical and straight), it is
preferable that body 34 have a slight outward angular taper. An
angular shape allows for tolerance variations and assures an
interference fit between plug 30 and vial 10, thereby sealing plug
30 inside vial 10.
[0043] In the exemplary embodiment, the thickness of button 40, at
least at its center, is about 0.051 cm (0.02 inches). The diameter
of central opening 38 is about 0.813 cm (0.320 inches). The length
of flange 32 is about 0.152 cm (0.06 inches) and the width of
flange 32, which also defines the maximum width of plug 30, is
about 1.207 cm (0.475 inches).
[0044] The length of plug 30 between the top 46 and the bottom 48
(i.e., the overall length of plug 30) is about 0.559 cm (0.220
inches) in the exemplary embodiment. The length between top 46 and
the flat portion 52 of button 40 is about 0.330 cm (0.130 inches).
The length between bottom 48 and the junction 54, between body 34
and base 36, is about 0.152 cm (0.060 inches). The diameter of base
36 is about 1.029 cm (0.405 inches) and the diameter of the base 36
between apical points 56 is about 0.770 cm (0.303 inches). Finally,
the diameter of plug 30 at the points where underside 44 contacts
body 34 is about 1 cm (0.390 inches).
[0045] In practice, the user aligns base 36 of plug 30 with center
opening 20 of head 12 of vial 10 and pushes downward on plug 30.
The resultant downward movement of plug 30 toward vial 10 causes
body 36 of plug 30 to engage the walls of head 12 of vial 10
defining the first chamber. The downward force overcomes the
friction generated by the interference fit and is maintained by the
user until underside 44 of top flange 32 contacts top 18 of head
12. At that point, plug 30 is fully inserted into vial 10. A
tactile (and, at least on occasion, an audible) seating informs the
user that insertion has been completed.
[0046] Thus, vial and plug combination 50 permits ease of sealing
vial 10 by simply pushing plug 30 into the ID of head 12 of vial
10. The integrity of the seal between vial 10 and plug 30 provides
another advantage to vial and plug combination 50. Specifically,
in-house tests conducted with a volatile solvent showed evaporation
loss equivalent to that of a crimped aluminum seal. Given the
excellent sealing properties, assured by multiple interference
contacts between body 34 of plug 30 and points x and y of vial 10
(see FIG. 6), vial and plug combination 50 can be used in long-term
storage.
[0047] Typically, in chromatograghy applications, the user must
fill a syringe with solution, attach a filter, and then fill the
vial. Three, separate components are required (namely a syringe, a
plunger, and a filter) to obtain a filtered solution. Vial and plug
combination 50 gives the user the ability to filter solutions in
vial 10 by simply pressing a tubular filter 70 or a hollow tubular
filter 78 (with one end closed) into vial 10. FIGS. 10A and 11A
illustrate tubular filter 70 and hollow tubular filter 78,
respectively, upon insertion into vial 10 having an unfiltered
solution 72. As shown in FIGS. 10B and 11B, tubular filter 70 and
hollow tubular filter 78, respectively, are in place within vial 10
as sealed by plug 30, yielding a filtered solution 74. Therefore,
vial and plug combination 50 offers improved economy: the
conventional three-piece syringe, plunger, and filter are replaced
with one unit.
[0048] Although illustrated and described above with reference to
certain specific embodiments, the present invention is nevertheless
not intended to be limited to the details shown. Rather, various
modifications may be made in the details within the scope and range
of equivalents of the claims and without departing from the spirit
of the invention.
* * * * *