U.S. patent application number 09/791196 was filed with the patent office on 2003-05-22 for method for the prophylaxis and/or treatment of proliferative and/or inflammatory skin disorders.
This patent application is currently assigned to ROYAL CHILDREN'S HOSPITAL RESEARCH FOUNDATION. Invention is credited to Werther, George Arthur, Wraight, Christopher John.
Application Number | 20030096769 09/791196 |
Document ID | / |
Family ID | 3781291 |
Filed Date | 2003-05-22 |
United States Patent
Application |
20030096769 |
Kind Code |
A1 |
Werther, George Arthur ; et
al. |
May 22, 2003 |
Method for the prophylaxis and/or treatment of proliferative and/or
inflammatory skin disorders
Abstract
The present invention relates generally to a method for the
prophylaxis and/or treatment of skin disorders, and in particular
proliferative and/or inflammatory skin disorders, and to genetic
molecules useful for same. The present invention is particularly
directed to genetic molecules capable of modulating growth factor
interaction with its receptor on epidermal keratinocytes to
inhibit, reduce or otherwise decrease stimulation of this layer of
cells. The present invention contemplates, in a most preferred
embodiment, a method for the prophylaxis and/or treatment of
psoriasis.
Inventors: |
Werther, George Arthur;
(Camberwell, AU) ; Wraight, Christopher John;
(Blackburn, AU) |
Correspondence
Address: |
BAKER & BOTTS, L.L.P.
30 ROCKEFELLER PLAZA
NEW YORK
NY
10112-0228
US
|
Assignee: |
ROYAL CHILDREN'S HOSPITAL RESEARCH
FOUNDATION
|
Family ID: |
3781291 |
Appl. No.: |
09/791196 |
Filed: |
February 23, 2001 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
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09791196 |
Feb 23, 2001 |
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09199926 |
Nov 25, 1998 |
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6284741 |
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09199926 |
Nov 25, 1998 |
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08666392 |
Aug 20, 1996 |
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5929040 |
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08666392 |
Aug 20, 1996 |
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PCT/AU95/00410 |
Jul 6, 1995 |
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Current U.S.
Class: |
514/44A |
Current CPC
Class: |
A61P 29/00 20180101;
A61P 17/00 20180101; A61K 31/7088 20130101; A61K 31/7125 20130101;
A61P 17/06 20180101; A61P 35/00 20180101; A61K 31/7105 20130101;
A61K 31/711 20130101; A61P 43/00 20180101 |
Class at
Publication: |
514/44 |
International
Class: |
A61K 048/00 |
Foreign Application Data
Date |
Code |
Application Number |
Jul 8, 1994 |
AU |
PM6725/94 |
Claims
1. A method for ameliorating the effects of a proliferative and/or
inflammatory skin disorder in a mammal, said method comprising
contacting the proliferating and/or inflamed skin or skin capable
of proliferation and/or inflammation with an effective amount of a
nucleic acid molecule or chemical analogue thereof capable of
inhibiting or otherwise reducing growth factor mediated cell
proliferation and/or inflammation.
2. A method according to claim 1 wherein cell proliferation and/or
inflammation is mediated by at least one of insulin-like growth
factor I (IGF-I ), keratinocyte growth factor (KGF), transforming
growth factor-.alpha. (TGF.alpha.), tumour necrosis factor-.alpha.
(TNF.alpha.), interleukin (IL)-1 (IL-1), IL-4, IL-6, IL-8 and/or
basic fibroblast growth factor (bFGF).
3. A method according to claim 2 wherein cell proliferation and/or
inflammation is mediated by IGF-I.
4. A method according to claim 1 wherein the nucleic acid molecule
inhibits or otherwise reduces IGF-I mediated cell proliferation
and/or inflammation.
5. A method according to claim 1 wherein the proliferative or
inflammatory skin disorder is psoriasis, ichthyosis, pityriasis,
rubra, pilaris, serborrhoea, keloids, keratosis, neoplasias,
scleroderma, warts, benign growths or cancers of the skin.
6. A method according to claim 5 wherein the skin condition is
psoriasis.
7. A method according to claim 1 or 4 or 6 wherein the mammal is a
human.
8. A method according to claim 1 or 4 or 6 wherein the nucleic acid
molecule is capable of inhibiting, reducing or otherwise
interfering with IGF-I-interaction with its receptor.
9. A method according to claim 8 wherein the nucleic acid molecule
is an antisense molecule capable of reducing expression of a gene
encoding IGF-I, IGF-I-receptor or an IGF binding protein
(IGFBP).
10. A method according to claim 9 wherein the nucleic acid molecule
is an antisense molecule capable of reducing expression of a gene
encoding IGFBP-2, -3, -4, -5 or -6.
11. A method according to claim 10 wherein the nucleic acid
molecule is an antisense molecule capable of reducing expression of
a gene encoding IGFBP-2 or IGFBP-3.
12. A method according to claim 11 wherein the antisense molecule
is at least about 15 nucleotides in length and is capable of
interacting with at least one sequence selected from the list set
forth in Example 6 or Example 7.
13. A method according to claim 11 wherein the antisense molecule
comprises the nucleotide sequence:
8 5'-ATCTCTCCGCTTCCTTTC-3'. [SEQ ID NO:10]
14. A nucleic acid molecule comprising at least about 10
nucleotides capable of hybridising to or forming a heteroduplex or
otherwise interacting with an RNA molecule directed from a gene
corresponding to a genomic form of SEQ ID NO: 1 and/or SEQ ID NO: 2
and which thereby reduces or inhibits translation of said RNA
molecule.
15. A nucleic acid molecule according to claim 14 wherein said
molecule comprises at least about 15 nucleotides.
16. A nucleic acid molecule according to claim 15 wherein said
molecule is capable of interacting with at least one nucleotide
sequence selected from the list set forth in Example 6 and Example
7.
17. A nucleic acid molecule according to claim 15 or 16 comprising
the nucleotide sequence:
9 5'-ATCTCTCCGCTTCCTTTC-3'. [SEQ ID NO:10]
18. A method of ameliorating the effects of psoriasis, said method
comprising contacting proliferating skin or skin capable of
proliferation with an effective amount of one or more nucleic acid
molecules or chemical analogues thereof capable of inhibiting or
otherwise reducing IGF-I mediated cell proliferation wherein said
one or more molecules comprises a polynucleotide capable of
interacting with mRNA directed from an IGF-I gene, an IGF-I
receptor gene or a gene encoding an IGFBP.
19. A method according to claim 18 wherein the IGFBP is IGFBP-2 or
IGFBP-3.
20. A method according to claim 18 or 19 wherein the mammal is a
human.
21. A method according to claim 20 wherein the nucleic acid
molecule is capable of interacting with a nucleotide sequence
selected from the list set forth in Example 6 or Example 7.
22. A method according to claim 18 wherein the nucleic acid
molecule comprises the nucleotide sequence:
10 5'-ATCTCTCCGCTTCCTTTC-3'. [SEQ ID NO:10]
23. A pharmaceutical composition for topical administration said
composition comprising a nucleic acid molecule capable of
inhibiting or otherwise reducing IGF-I mediated cell proliferation
said composition further comprising one or more pharmaceutically
acceptable carriers and/or diluents.
24. A pharmaceutical composition according to claim 23 wherein the
nucleic acid molecule is an antisense molecule to a gene encoding
IGF-I, IGF-I-receptor or an IGFBP.
25. A pharmaceutical composition according to claim 24 wherein the
nucleic acid molecule is capable of targeting a gene encoding
IGFBP-2 and/or IGFBP-3.
26. A pharmaceutical composition according to claim 24 capable of
interacting with at least one nucleotide sequence set forth in
Example 6 or Example 7.
27. Use of a nucleic acid molecule in the manufacture of a
medicament for the treatment of a proliferative and/or inflammatory
skin disorder mediated by IGF-I.
28. Use according to claim 27 wherein the skin disorder is
psoriasis.
29. A ribozyme comprising a hybridising region and a catalytic
region wherein the hybridising region is capable of hybridising to
at least part of a target mRNA sequence transcribed from a genomic
gene corresponding to SEQ ID NO: 1or SEQ ID NO: 2 wherein said
catalytic domain is capable of cleaving said target mRNA sequence
to reduce or inhibit IGF-I mediated cell proliferation or
inflammation.
Description
[0001] The present invention relates generally to a method for the
prophylaxis and/or treatment of skin disorders, and in particular
proliferative and/or inflammatory skin disorders, and to genetic
molecules useful for same. The present invention is particularly
directed to genetic molecules capable of modulating growth factor
interaction with its receptor on epidermal keratinocytes to
inhibit, reduce or otherwise decrease stimulation of this layer of
cells. The present invention contemplates, in a most preferred
embodiment, a method for the prophylaxis and/or treatment of
psoriasis.
[0002] Bibliographic details of the publications numerically
referred to in this specification are collected at the end of the
description. Sequence Identity Numbers (SEQ ID NOs.) for the
nucleotide sequences referred to in the specification are defined
following the bibliography.
[0003] Throughout this specification, unless the context requires
otherwise, the word "comprise", or variations such as "comprises"
or "comprising", will be understood to imply the inclusion of a
stated element or integer or group of elements or integers but not
the exclusion of any other element or integer or group of elements
or integers.
[0004] Psoriasis and other similar conditions are common and often
distressing proliferative and/or inflammatory skin disorders
affecting or having the potential to affect a significant
proportion of the population. The condition arises from over
proliferation of basal keratinocytes in the epidermal layer of the
skin associated with inflammation in the underlying dermis. Whilst
a range of treatments have been developed, none is completely
effective and free of adverse side effects. Although the underlying
cause of psoriasis remains elusive, there is some consensus of
opinion that the condition arises at least in part from over
expression of local growth factors and their interaction with their
receptors supporting keratinocyte proliferation via keratinocyte
receptors which appear to be more abundant during psoriasis.
[0005] One important group of growth factors are the
dermally-derived insulin-like growth factors (IGFs) which support
keratinocyte proliferation. In particular, IGF-I and IGF-II are
ubiquitous peptides each with potent mitogenic effects on a broad
range of cells. Molecules of the IGF type are also known as
"progression factors" promoting "competent" cells through DNA
synthesis. The IGFs act through a common receptor known as the Type
I or IGF-I receptor, which is tyrosine kinase linked. They are
synthesised in mesenchymal tissues, including the dermis, and act
on adjacent cells of mesodermal, endodermal or ectodermal origin.
The regulation of their synthesis involves growth hormone (GH) in
the liver, but is poorly defined in most tissues (1).
[0006] Particular proteins, referred to as IGF binding proteins
(IGFBPs), appear to be involved in autocrine/paracrine regulation
of tissue IGF availability (2). Six IGFBPs have so far been
identified. The exact effects of the IGFBPs is not clear and
observed effects in vitro have been inhibitory or stimulatory
depending on the experimental method employed (3). There is some
evidence, however, that certain IGFBPs are involved in targeting
IGF-I to its cell surface receptor.
[0007] Skin, comprising epidermis and underlying dermis, has GH
receptors on dermal fiboblasts (4). Fibroblasts synthesize IGF-I as
well as IGFBPs-3, -4, -5 and -6 (5) which may be involved in
targeting IGF-I to adjacent cells as well as to the overlaying
epidermis. The major epidermal cell type, the keratinocyte, does
not synthesize IGF-I, but possesses IGF-I receptors and is
responsive to IGF-I (6).
[0008] It is apparent, therefore, that IGF-I and other growth
promoting molecules, are responsible for or at least participate in
a range of skin cell activities. In accordance with the present
invention, the inventors have established that abberations in the
normal functioning of these molecules or abberations in their
interaction with their receptors is an important factor in
proliferative and/or inflammatory skin disorders. It is proposed,
therefore, to target these molecules or other molecules which
facilitate their functioning or interaction with their receptors to
thereby ameliorate the effects of abberant activity during or
leading to skin disease conditions.
[0009] Accordingly, one aspect of the present invention
contemplates a method for ameliorating the effects of a
proliferative and/or inflammatory skin disorder in a mammal, said
method comprising contacting the proliferating and/or inflamed skin
or skin capable of proliferation and/or inflammation with an
effective amount of a nucleic acid molecule or chemical analogue
thereof capable of inhibiting or otherwise reducing a growth factor
mediated cell proliferation and/or inflammation. Growth factor
mediated cell proliferation and inflammation are also referred to
as epidermal hyperplasias and may be mediated by any number of
molecules such as but not limited to IGF-I, keratinocyte growth
factor (KGF), transforming growth factor-.alpha. (TGF.alpha.),
tumour necrosis factor-.alpha. (TNF.alpha.), interleukin-1, -4, -6
and 8 (IL-1, IL-4, IL-6 and IL-8, respectively), basic fibroblast
growth factor (bFGF) or a combination of one or more of the above.
The present invention is particularly described and exemplified
with reference to IGF-I and its receptor (IGF-I receptor) and to
IGF-I facilitating molecules, IGFBPs, since targeting these
molecules according to the methods contemplated herein provides the
best results to date. This is done, however, with the understanding
that the present invention extends to any growth factor or
cytokine-like molecule, a receptor thereof or a facilitating
molecule like the IGFBPs involved in skin cell proliferation such
as those molecules contemplated above and/or their receptors and/or
facilitating molecules therefor.
[0010] According to this preferred embodiment, there is provided a
method for ameliorating the effects of a proliferative and/or
inflammatory skin disorder in a mammal, said method comprising
contacting the proliferating and/or inflamed skin or skin capable
of proliferation and/or inflammation with an effective amount of a
nucleic acid molecule or chemical analogue thereof capable of
inhibiting or otherwise reducing IGF-I mediated cell proliferation
and/or inflammation.
[0011] The present invention is particularly described by psoriasis
as the proliferative skin disorder. However, the subject invention
extends to a range of proliferative and/or inflammatory skin
disorders or epidermal hyperplasias such as but not limited to
psoriasis, ichthyosis, pityriasis rubra pilaris ("PRP"),
seborrhoea, keloids, keratoses, neoplasias and scleroderma, warts,
benign growths and cancers of the skin.
[0012] In a preferred embodiment, therefore, the present invention
is directed to a method for ameliorating the effects of psoriasis,
said method comprising contacting proliferating skin or skin
capable of proliferation with an effective amount of a nucleic acid
molecule or chemical analogue thereof capable of inhibiting or
otherwise reducing IGF-I mediated cell proliferation.
[0013] The present invention extends to any mammal such as but not
limited to humans, livestock animals (e.g. horses, sheep, cows,
goats, pigs, donkeys), laboratory test animals (e.g. rabbits, mice,
guinea pigs), companion animals (e.g. cats, dogs) and captive wild
animals. However, the instant invention is particularly directed to
proliferative and/or inflammatory skin disorders such as psoriasis
in humans.
[0014] The aspects of the subject invention instantly contemplated
are particularly directed to the topical application of one or more
suitable nucleic molecules capable of inhibiting, reducing or
otherwise interfering with IGF-mediated cell proliferation and/or
inflammation. More particularly, the nucleic acid molecule targets
IGF-I interaction with its receptor. Conveniently, therefore, the
nucleic acid molecule is an antagonist of IGF-I interaction with
its receptor. Most conveniently, the nucleic acid molecule
antagonist is an antisense molecule to the IGF-I receptor, to IGF-I
itself or to a molecule capable of facilitating IGF-I interaction
with its receptor such as but not limited to an IGFBP.
[0015] Insofar as the invention relates to IGFBPs, the preferred
molecules are IGFBP-2, -3, -4, -5 and -6. The most preferred
molecules are IGFBP-2 and IGFBP-3.
[0016] The nucleotide sequences of IGFBP-2 and IGFBP-3 are set
forth in FIGS. 1 (SEQ ID NO. 1) and 2 (SEQ ID NO. 2), respectively.
According to a particularly preferred aspect of the present
invention, there is provided a nucleic acid molecule comprising at
least about ten nucleotides capable of hybridising to, forming a
heterodouplex or otherwise interacting with an mRNA molecule
directed from a gene corresponding to a genomic form of SEQ ID NO.
1 and/or SEQ ID NO. 2 and which thereby reduces or inhibits
translation of said mRNA molecule. Preferably, the nucleic acid
molecule is at least about 15 nucleotides in length and more
preferably at least about 20-25 nucleotides in length. However, the
instant invention extends to any length nucleic acid molecule
including a molecule of 100-200 nucleotides in length to correspond
to the full length of or near full length of the subject genes.
[0017] The nucleotide sequence of the antisense molecules may
correspond exactly to a region or portion of SEQ ID NO. 1 or SEQ ID
NO. 2 or may differ by one or more nucleotide substitutions,
deletions and/or additions. It is a requirement, however, that the
nucleic acid molecule interact with an mRNA molecule to thereby
reduce its translation into active protein.
[0018] Examples of potential antisense molecules for IGFBP-2 and
IGFBP-3 are those capable of interacting with sequences selected
from the lists in Examples 6 and 7, respectively.
[0019] The nucleic acid molecules in the form of an antisense
molecule may be linear or covalently closed circular and single
stranded or partially double stranded. A double stranded molecule
may form a triplex with target mRNA or a target gene. The molecule
may also be protected from, for example, nucleases, by any number
of means such as using a nonionic backbone or a phosphorothioate
linkage. A convenient nonionic backbone contemplated herein is
ethylphosphotriester linkage or a 2'-O-methylribosyl
derivative.
[0020] Examples of suitable oligonucleotide analogues are
conveniently described in Ts'O et al (7).
[0021] Alternatively, the antisense molecules of the present
invention may target the IGF-I gene itself or its receptor or a
multivalent antisense molecule may be constructed or separate
molecules administered which target at least two or an IGFBP, IGF-I
and/or IGF-I-receptor. Examples of suitable antisense molecules
capable of targetting the IGF-I receptor are those capable of
interacting with sequences selected from the list in Example 8. One
particularly useful antisense molecule is 5'-ATCTCTCCGCTTCCTTTC-3'
(SEQ ID NO. 10). A particularly preferred embodiment of the present
invention contemplates a method of ameliorating the effects of
psoriasis, said method comprising contacting proliferating skin or
skin capable of proliferation with an effective amount of one or
more nucleic acid molecules or chemical analogues thereof capable
of inhibiting or otherwise reducing IGF-I mediated cell
proliferation wherein said one or more molecules comprises a
polynucleotide capable of interacting with mRNA directed from two
or more of an IGF-I gene, an IGF-I receptor gene or a gene encoding
an IGFBP such as IGFBP-2 and/or IGFBP-3.
[0022] In accordance with one aspect of the present invention the
nucleic acid molecule is topically applied in aqueous solution or
in conjunction with a cream, ointment, oil or other suitable
carrier and/or diluent. A single application may be sufficient
depending on the severity or exigencies of the condition although
more commonly, multiple applications are required ranging from
hourly, multi-hourly, daily, multi-daily, weekly or monthly, or in
some other suitable time interval. The treatment might comprise
solely the application of the nucleic acid molecule or this may be
applied in conjunction with other treatments for the skin
proliferation and/or inflammatory disorder being treated or for
other associated conditions including microbial infection, bleeding
and the formation of a variety of rashes.
[0023] As an alternative to or in conjunction with antisense
therapy, the subject invention extends to the nucleic acid molecule
as, or incorporating, a ribozyme including a minizyme to, for
example, IGF-I, its receptor or to molecules such as IGFBPs and in
particular IGFBP-2 and -3. Ribozymes are synthetic nucleic acid
molecules which possess highly specific endoribonuclease activity.
In particular, they comprise a hybridising region which is
complementary in nucleotide sequence to at least part of a target
RNA. Ribozymes are well described by Haseloff and Gerlach (8) and
in International Patent Application No. WO 89/05852. The present
invention extends to ribozymes which target mRNA specified by genes
encoding IGF-I, its receptor or one or more IGFBPs such as IGFBP-2
and/or IGFBP-3.
[0024] According to this embodiment, there is provided in a
particularly preferred aspect a ribozyme comprising a hybridising
region and a catalytic region wherein the hybridising region is
capable of hybridising to at least part of a target mRNA sequence
transcribed from a genomic gene corresponding to SEQ ID NO. 1 or
SEQ ID NO. 2 wherein said catalytic domain is capable of cleaving
said target mRNA sequence to reduce or inhibit IGF-I mediated cell
proliferation and/or inflammation.
[0025] Yet another aspect of the present invention contemplates
co-suppression to reduce expression or to inhibit translation of an
endogenous gene encoding, for example, IGF-I, its receptor, or
IGFBPs such as IGFBP-2 and/or -3. In co-suppression, a second copy
of an endogenous gene or a substantially similar copy or analogue
of an endogenous gene is introduced into a cell following topical
administration. As with antisense molecules, nucleic acid molecules
defining a ribozyme or nucleic acid molecules useful in
co-suppression may first be protected such as by using a nonionic
backbone.
[0026] The efficacy of the nucleic acid molecules of the present
invention can be conveniently tested and screened using an in vitro
system comprising a basal keratinocyte cell line. A particularly
useful system comprises the HaCaT cell line described by Boukamp et
al (9). In one assay, IGF-I is added to an oligonucleotide treated
HaCaT cell line. Alternatively, growth of oligonucleotide treated
HaCaT cells is observed on a feeder layer of irradiated 3T3
fibroblasts. Using such in vitro assays, it is observed that
antisense oligonucleotides to IGFBP-3, for example, inhibit
production of IGFBP-3 by HaCaT cells. Other suitable animal models
include the nude mouse/human skin graft model (15; 16) and the
"flaky skin" mouse model (17; 18). In the nude mouse model,
microdermatome biopsies of psoriasis lesions are taken under local
anaesthetic from volunteers then transplanted to congenital athymic
(nude) mice. These transplanted human skin grafts maintain the
characteristic hyperproliferating epidermis for 6-8 weeks. They are
an established model for testing the efficacy of topically applied
therapies for psoriasis. In the "flaky skin" mouse model, the
fsn/fsn mutation produces mice with skin resembling human
psoriasis. This mouse, or another mutant mouse with a similar
phenotype is a further in vivo model to test the efficacy of
topically applied therapies for psoriasis.
[0027] Another aspect of the present invention contemplates a
pharmaceutical composition for topical administration which
comprises a nucleic acid molecule capable of inhibiting or
otherwise reducing IGF-I mediated cell proliferation such as
psoriasis and one or more pharmaceutically acceptable carriers
and/or diluents. Preferably, the nucleic acid molecule is an
antisense molecule to IGF-I, the IGF-I receptor or an IGFBP such as
IGFBP-2 and/or IGFBP-3 or comprises a ribozyme to one or more of
these targets or is a molecule suitable for co-suppression of one
or more of these targets. The composition may comprise a single
species of a nuleic acid molecule capable of targeting one of
IGF-I, its receptor or an IGFBP, such as IGFBP-2 or IGFBP-3 or may
be a multi-valent molecule capable of targeting two or more of
IGF-I, its receptor or an IGFBP, such as IGFBP-2 and/or
IGFBP-3.
[0028] The nucleic acid molecules may be administered in
dispersions prepared in creams, ointments, oil or other suitable
carrier and/or diluent such as glycerol, liquid polyethylene
glycols and/or mixtures thereof. Under ordinary conditions of
storage and use, these preparations may contain a preservative to
prevent the growth of microorganisms.
[0029] The pharmaceutical forms suitable for topical use include
sterile aqueous solutions (where water soluble) or dispersions and
powders for the extemporaneous preparation of topical solutions or
dispersion. In all cases, the form is preferably sterile although
this is not an absolute requirement and is stable under the
conditions of manufacture and storage. The carrier can be a solvent
or dispersion medium containing, for example, water, ethanol,
polyol (for example, glycerol, propylene glycol, and liquid
polyethylene glycol, and the like), suitable mixtures thereof and
vegetable oils. The proper fluidity can be maintained, for example,
by the use of a coating such as lecithin, by the maintenance of the
required particle size in the case of dispersion and by the use of
superfactants. The prevention of the action of microorganism can be
brought about by various antibacterial and antifungal agents, for
example, parabens, chlorobutanol, phenol, sorbic acid, thirmerosal
and the like. In many cases, it will be preferable to include
isotonic agents, for example, sugars or sodium chloride.
[0030] Topical solutions arc prepared by incorporating the nucleic
acid molecule compound in the required amount in the appropriate
solvent with various of the other ingredients enumerated above, as
required, followed by where necessary filter sterilization.
[0031] As used herein "pharmaceutically acceptable carriers and/or
diluents" include any and all solvents, dispersion media, aqueous
solutions, coatings, antibacterial and antifungal agents, isotonic
and absorption delaying agents, and the like. The use of such media
and agents for pharmaceutical active substances is well known in
the art. Except insofar as any conventional media or agent is
incompatable with the active ingredient, use thereof in the
pharmaceutical compositions is contemplated. Supplementary active
ingredients can also be incorporated into the compositions.
Conveniently, the nucleic acid molecules of the present invention
are stored in freeze-dried form and are reconstituted prior to
use.
[0032] Yet another aspect of the present invention contemplates the
use of a nucleic acid molecule in the manufacture of a medicament
for the treatment of proliferative and/or inflammatory skin
disorders mediated by a growth factor. The proliferative and/or
inflammatory skin disorder is generally psoriasis and the nucleic
acid molecule targets IGF-I, the IGF-I receptor and/or an IGFBP
such as IGFBP-2 and/or IGFBP-3.
[0033] Still a further aspect of the present invention contemplates
an agent comprising a nucleic acid molecule as hereinbefore defined
useful in the treatment of proliferative and/or inflammatory skin
disorders, such as psoriasis.
[0034] The present invention is further described by the following
non-limiting Figures and/or Examples.
[0035] In the Figures:
[0036] FIG. 1 is a representation of the nucleotide sequence of
IGFBP-2.
1 LOCUS HSIGFBP2 1433 bp RNA PRI 31-JAN-1990 DEFINITION Human mRNA
for insulin-like growth factor binding protein (IGFBP-2) ACCESSION
X16302 KEYWORDS insulin-like growth factor binding protein. SOURCE
human ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa; Chordata;
Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini;
Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 1433) AUTHORS
Binkert,C., Landwehr,J., Mary,J.L., Schwander,J. and Heinrich,G.
TITLE Cloning, sequence analysis and expression of a cDNA encoding
a novel insulin-like growth factor binding protein (IGFBP-2)
JOURNAL EMBO J. 8, 2497-2502 (1989) STANDARD full automatic COMMENT
NCBI gi: 33009 FEATURES Location/Qualifiers source 1. .1433
/organism="Homo sapiens" /dev_stage="fetal" /tissue_type="liver"
misc_feature 1416. .1420 /note="pot. polyadenylation signal"
polyA_site 1433 /note="polyadenylation site" CDS 118. .1104
/note="precursor polypeptide; (AA -39 to 289); NCBI gi: 33010."
/codon_start=1 /translation="MLPRVGCPALPLPPPPLLPLLPLLLL-
LLGASGGGGGARAEVLFR CPPCTPERLAACGPPPVAPPAAVAAVAGGARMPCAELVREPGCGCC-
SVCARLEGEACG VYTPRCGQGLRCYPHPGSELPLQALVMGEGTCEKRRDAEYGASPEQVADNGD-
DHSEGG LVENHVDSTMNMLGGGGSAGRKPLKSGMKELAVFREKVTEQHRQMGKGGKHHLGLEEP
KKLRPPPARTPCQQELDQVLERISTMRLPDERGPLEHLYSLHIPNCDKHGLYNLKQCK
MSLNGQRGECWCVNPNTGKLIQGAPTIRGDPECHLFYNEQQEACGVHTQRMQ" CDS 118. .234
/note="signal peptide; (AA -39 to -1); NCBI gi: 33011."
/codon_start=1 /translation="MLPRVGCPALPLPPPPLLPLLPLLLLLLGA-
SGGGGGARA" CDS 235. .1101 /note="mature IGFBP-2; (AA 1 to 289);
NCBI gi: 33012." /codon_start=1
/translation="EVLFRCPPCTPERLAACGPPPVAPPAAVAAVAGGARMPCAELVR
EPGCGCCSVCARLEGEACGVYTPRCGQGLRCYPHPGSELPLQALVMGEGTCEKRRDAE
YGASPEQVADNGDDHSEGGLVENHVDSTMNMLGGGGSAGRKPLKSGMKELAVFREKVT
EQHRQMGKGGKHHKGLEEPKKLRPPPARTPCQQELDQVLERISTMRLPDERGPLEHLY
SLHIPNCDKEGLYNLKQCKMSLNGQRGECWCVNPNTGKLIQGAPTIRGDPECHLFYNE
QQEACGVHTQRMQ" BASE COUNT 239 a 466 c 501 g 227 t ORIGIN HSIGFBP2
Length: 1433 May 11, 1994 10:06 Type: N Check: 6232 ..
[0037] FIG. 2 is a representation of the nucleotide sequence of
IGFBP-3.
2 LOCUS HUMGFIBPA 2474 bp ss-mRNA PRI 15-JUN-1990 DEFINITION Human
growth hormone-dependent insulin-like growth factor-binding protein
mRNA, complete cds. ACCESSION M31159 KEYWORDS insulin-like growth
factor binding protein. SOURCE Human plasma, eDNA to mRNA, clone
BP-53. ORGANISM Homo sapiens Eukaryota; Animalia; Chordata;
Vertebrata; Mammalia; Theria; Eutheria; Primates; Haplorhini;
Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 2474) AUTHORS
Wood,W.I., Cachianes,G., Henzel,W.J., Winslow,G.A., Spencer,S.A.,
Hellmiss,R., Martin,J.L. and Baxter,R.C. TITLE Cloning and
expression of the growth hormone-dependent insulin-like growth
factor-binding protein JOURNAL Mol. Endocrinol. 2, 1176-1185 (1988)
STANDARD full automatic COMMENT NCBI gi: 183115 FEATURES
Location/Qualifiers mRNA <1. .2474 /note="GFIBP mRNA" CDS 110.
.985 /gene="IGFBP1" /note="insulin-like growth factor-binding
protein; NCBI gi: 183116." /codon_start=1
/translation="MQRARPTLWAAALTLLV- LLRGPPVARAGASSGGLGPVVRCEPCD
ARALAQCAPPPAVCAELVREPGCGCCLTCALSEGQPC- GIYTERCGSGLRCQPSPDEAR
PLQALLDGRGLCVNASAVSRLAYLLJPAPPAPGNASESEEDRS- AGSVESPSVSSTHRV
SDPKFWPLHSKIIIIKKGHAKDSQRYKDYESQSTDTQNFSSESKRETEY- GPCRREME
DTLNHLKFLNVLSPRGHIPNCDKKGFYKKKKQCRPSKGRKRGFCWCVCDKYGQPLP- GYT
TKGKEDVHCYSMQSK" source 1. .2474 /organism="Homo sapiens" BASE
COUNT 597 a 646 c 651 g 580 t ORIGIN HUMGFIBPA Length: 2474 May 11,
1994 10:00 Type: N Check: 9946 ..
[0038] FIG. 3 is a representation of the nucleotide sequence of
IGF-l-receptor.
3 LOCUS HSIGFIRR 4989 bp RNA PRI 28-MAR-1991 DEFINITION Human mRNA
for insulin-like growth factor I receptor ACCESSION X04434 M24599
KEYWORDS glycoprotein; insulin receptor; insulin-like growth factor
I receptor; membrane glycoprotein; receptor; tyrosine kinase.
SOURCE human ORGANISM Homo sapiens Eukaryota; Animalia; Metazoa;
Chordata; Vertebrata; Mammalia; Theria; Eutheria; Primates;
Haplorhini; Catarrhini; Hominidae. REFERENCE 1 (bases 1 to 4989)
AUTHORS Ullrich,A., Gray,A., Tam,A.W., Yang-Feng,T., Tsubokawa,M.,
Collins,C., Henzel,W., Bon,T.L., Kathuria,S., Chen,E., Jakobs,S.,
Francke , U., Ramachandran, J. and Fujita-Yamaguchi, Y. TITLE
Insulin-like growth factor I receptor primary structure: comparison
with insulin receptor suggests structural dererminants that define
functional specificity JOURNAL EMBO J. 5, 2503-2512 (1986) STANDARD
full automatic COMMENT NCBI gi: 33058 FEATURES Location/Qualifiers
source 1. .4989 /organism="Homo sapiens" /tissue_type="placenta"
/clone.sub.--lib=" (lamda)gt10" /clone=" (lambda) IGF-1-R.85,
(lambda) IGF-1-R.76" sig_peptide 32. .121 mat_peptide 122. .4132
/note="IGF-I receptor" misc_feature 122. .2251 /note="alpha-subunit
(AA 1 - 710)" misc_feature 182. .190 /note="pot.N-linked
glycosylation site (AA 21 - 23)" misc_feature 335. .343
/note="pot.N-linked glycostlation site (AA 72 - 74)" misc_feature
434. .442 /note="pot.N-linked glycostlation site (AA 105 - 107)"
misc_feature 761. .769 /note="pot.N-linked glycostlation site (AA
214 - 216)" misc_feature 971. .979 /note="pot.N-linked
glycostlation site (AA 284 - 286)" misc feature 1280. .1288
/note="pot.N-linked glycostlation site (AA 387 - 389)" misc_feature
1343. .1351 /note="pot.N-linked glycosylation site (AA 408 - 410)"
misc_feature 1631. .1639 /note="pot.N-linked glycostlation site (AA
504 - 506)" misc_feature 1850. .1858 /note="pot.N-linked
glycosylation site (AA 577 - 579)" misc feature 1895. .1903
/note."pot.N-linked glycosylation site (AA 592 - 594)" misc_feature
1949. .1957 /note="pot.N- linked glycosylation site (AA 610 - 612)"
misc_feature 2240. .2251 /note="putative proreceptor processing
site (AA 707 - 710)" misc_feature 2252. .4132 /note="beta-subunit
(AA 711 - 1337)" misc_feature 2270. .2278 /note="pot.N-linked
glycosylation site (AA 717 - 719]" misc_feature 2297. .2305
/note="pot.N-linked glycosylation site (AA 726 - 728)" misc feature
2321. .2329 /note="pot.N-linked glycosylation site (AA 734 - 736)"
misc_feature 2729. .2737 /note="pot.N-linked glycosylation site (AA
870 - 872)" misc feature 2768. .2776 /note="pot.N-linked
glycosylation site (AA 883 - 885)" misc_feature 2837. .2908
/note="transmembrane region (AA 906 - 929)" misc feature 2918.
.2926 /note="pot.N-linked glycosylation site (AA 933 - 935)"
misc_feature 3047. .3049 /note="pot.ATP binding site (AA 976)" misc
feature 3053. .3055 /note="pot.ATP binding site (AA 978)" misc
feature 3062. .3064 /note="pot.ATP binding site (AA 981)"
misc_feature 3128. .3130 /note="pot.ATP binding site (AA 1003)" CDS
32. .4132 /product="IGF-I receptor" /note="50 stops when
translation attempted, frame 1, code 0" BASE COUNT 1216 a 1371 c
1320 g 1082 t ORIGIN HSIGFIRR Length: 4989 May 11, 1994 12:10 Type:
N Check: 133 ..
[0039] FIG. 4A is a photographic representation of a Western ligand
blot of HaCaT conditioned medium showing IGFBP-3 secreted in 24
hours after 7 day treatment with phosphorothioate oligonucleotides
(BP3AS2, BP3AS3 and BP3S) at 0.5 .mu.M and 5 .mu.M; * no
oligonucleotide added.
[0040] FIG. 4B is a graphical representation of a scanning imaging
desitometry of Western ligand blot (FIG. 4A), showing relative band
intensities of IGFBP-3 and the 24 kDa IGFBP-4 after treatment with
phosphorothioate oligonucleotides; * no oligonucleotide added.
[0041] FIG. 5A is a photographic representation of a Western ligand
blot of HaCaT conditioned medium showing IGFBP-3 secreted in 24
hours after 7 day treatment with phosophorothioate oligonucleotide
BP3AS2 at 0.5 .mu.M compared with several control oligonucleotides
at 0.5 .mu.M. (a) oligonucleotide BP3AS2NS; (b) oligonucleotide
BP3AS4; (c) oligonucleotide BP3AS4NS; and (untreated), no
oligonucleotide added.
[0042] FIG. 5B is a graphical representation of a scanning imaging
densitometry of Western ligand blot (FIG. 5A), showing relative
band intensities of IGFBP-3 after treatment with phosphorothioate
oligonucleotides as in FIG. 5A, showing IGFBP-3 band intensities
expressed as a percentage of the average band intensity from
conditioned medium of cells not treated with oligonucleotide.
[0043] FIG. 6 is a graphical representation showing inhibition of
IGF-I binding by antisense oligonucleotides to IGF-I receptor.
IGFR.AS: antisense; IGFR.S: sense.
[0044] FIG. 7 is a graphical representation showing inhibition of
IGFBP-3 production in culture medium following initial treatment
with antisense oligonucleotides once daily over a 2 day period.
[0045] FIG. 8 is a graphical representation showing optimization of
IGFBP-3 antisense oligonucleotide concentration as determined by
relative IGFBP-3 concentration in culture medium.
EXAMPLE 1
In Vitro Assay
[0046] Cells
[0047] The differentiated human keratinocyte cell line, HaCaT (9)
was used in the in vitro assay. Cells at passage numbers 33 to 36
were maintained as monolayer cultures in 5% v/v CO.sub.2 at
37.degree. C. in Keratinocyte-SFM (Gibco) containing EGF and bovine
pituitary extract as supplied. Media containing foetal calf serum
were avoided because of the high content of IGF-I binding proteins
in serum.
[0048] Feeder layer plates of lethally irradiated 3T3 fibroblasts
were prepared exactly as described by Rheinwald and Green (10).
EXAMPLE 2
In Vitro Assay
[0049] Thymidine Incorporation Assay
[0050] Cells were grown to 4 days post confluence in 2 cm.sup.2
wells with daily medium changes of Keratinocyte-SFM, then the
medium was changed to DMEM (Cytosystems, Australia), with the
following additions: 25 mM Hepes, 0.19% w/v, sodium bicarbonate,
0.03% w/v glutamine (Sigma Chemical Co, USA), 50 IU/ml penicillin
and 50 .mu.g/ml streptomycin (Flow Laboratories). After 24 hours,
IGF-I or tIGF-I was added to triplicate wells, at the
concentrations indicated, in 0.5 ml fresh DMEM containing 0.02% v/v
bovine serum albumin (Sigma molecular biology grade) and incubated
for a further 21 hours. [.sup.3H]-Thymidine (0.1 .mu.Ci/well) was
then added and the cells incubated for a further 3 hours. The
medium was then aspirated and the cells washed once with ice-cold
PBS and twice with ice-cold 10% v/v TCA. The TCA-precipitated
monolayers were then solubilized with 0.25M NaOH (200 .mu.l/well),
transferred to scintillation vials and radioactivity determined by
liquid scintillation counting (Pharmacia Wallac 1410 liquid
scintillation counter).
EXAMPLE 3
Western Ligand Blotting
[0051] HaCaT conditioned medium (250 .mu.l) was concentrated by
adding 750 .mu.l cold ethanol, incubating at -20.degree. C. for 2
hours and centrifuging at 16,000 g for 20 min at 4.degree. C. The
resulting pellet was air dried, resuspended thoroughly in
non-reducing Laemmli sample buffer, heated to 90.degree. C. for 5
minutes and separated on 12% w/v SDS-PAGE according to the method
of Laemmli (1970). Separated proteins were electrophoretically
transferred to nitrocellulose membrane (0.45 mm, Schleicher and
Schuell, Dassel, Germany) in a buffer containing 25 mM Tris, 192 mM
glycine and 20% v/v methanol. IGFBPs were then visualised by the
procedure of Hossenlopp et al (11), using [.sup.125I]-IGF-I,
followed by autoradiography. Autoradiographs were scanned in a
BioRad Model GS-670 Imaging Densitometer and band densities were
determined using the Molecular Analyst program.
EXAMPLE 4
Antisense Oligonucleotides
[0052] Phosphorothioate oligodeoxynucleotides were synthesised by
Bresatec, Adelaide, South Australia, Australia. The following
antisense sequences were used: BP3AS2, 5'-GCG CCC GCT GCA TGA CGC
CTG CAA C-3' (SEQ ID NO. 4), a 25mer complementary to the start
codon region of the human IGFBP-3 mRNA; BP3AS3, 5'-CGG GCG GCT CAC
CTG GAG CTG GCG-3' (SEQ ID NO. 5), a 24 mer complementary to the
exon 1/intron 1 splice site; BP3AS4, 5'-AGG CGG CTG ACG GCA CTA-3'
(SEQ ID NO. 6), an 18 mer complementary to a region of the coding
sequence lacking RNA secondary structure and oligonucleotide-dimer
formation (using the computer software "OLIGO for PC"). Since
BP3AS4 was found to be ineffective at inhibiting IGFBP-3 synthesis,
it was used as a control. The following additional control
oligonucleotide sequences were used: BP3S, 5'-CAG GCG TCA TGC AGC
GGG C-3' (SEQ ID NO. 7), an 18 mer sense control sequence
equivalent to the start codon region; BP3AS2NS, 5'-CGG AGA TGC CGC
ATG CCA GCG CAG G-3' (SEQ ID NO. 8), a 25 mer randomised sequence
with the same GC content as BP3AS2; BP3AS4NS, 5'-GAC AGC GTC GGA
GCG ATC-3' (SEQ ID NO. 9), an 18 mer randomised sequence with the
same GC content as BP3AS4NS. Design of the oligonucleotides was
based on the human IGFBP-3 cDNA sequence of Spratt et al (12).
[0053] Cells were grown to one day post confluence in 2 cm.sup.2
wells with daily medium changes of 0.5 ml Keratinocyte-SFM, then
subjected to daily medium changes of Keratinocyte-SFM for a further
4 days. Daily additions of 0.5 ml fresh Keratinocyte-SFM were then
continued for a further 7 days, except that at the time of medium
addition, 5 .mu.l oligonucleotide in PBS was added to give the
final concentrations indicated, then the wells were shaken to mix
the oligonucleotide. After the final addition, cells were incubated
for 24 hours and the medium collected for assay of IGFBPs. Cells
were then counted after trypsinisation in a Coulter Industrial D
Counter, Coulter Bedfordshire, UK. Cell numbers after
oligonucleotide treatment differed by less than 10%.
EXAMPLE5
Antisense Oligonucleotides Inhibit IGFBP-3 Synthesis
[0054] HaCaT cells secrete mainly IGFBP-3 (>95%), with the only
other IGFBP detectable in HaCaT conditioned medium being IGFBP-4
(<5%). The effect on IGFBP-3 and IGFBP-4 synthesis of antisense
oligonucleotides at two concentrations, 5 .mu.M and 0.5 .mu.M, was
tested. Two oligonucleotides were used, BP3AS2 and BP3AS3, directed
against the start site and the intron 1/exon 1 splice site,
respectively of the IGFBP-3 mRNA. As a control, a sense
oligonucleotide corresponding to the start site was used. As shown
in FIGS. 4A and 4B, all oligonucleotides at 5 .mu.M caused a
significant reduction of IGFBP-3 synthesis compared with untreated
cells, however, the two antisense oligonucleotides inhibited
IGFBP-3 synthesis of approximately 50% compared to the sense
control (FIG. 4B). The antisense oligonucleotide directed to the
start codon appeared to be more effective of the two, the
difference being more apparent at the lower concentration of 0.5
.mu.M. The cells of IGFBP4 secreted by the HaCaT cells make
photographic reproduction of the bands on Western ligand blots
difficult, however densitometry measurements provide adequate
relative quantitation. This resulted in the significant observation
that IGFBP4 levels were unaffected by oligonucleotide addition to
the cells, suggesting that the observed inhibitory effects on
IGFBP-3 are specific.
[0055] To further investigate the inhibitory effects of the more
effective of the two antisense oligonucleotides, BP3AS2, inhibition
by this oligonucleotide at 0.5 .mu.M was compared with a number of
control oligonucleotides, including one antisense oligonucleotide
to IGFBP-3 that had proved to be ineffective at 0.5 .mu.M. As shown
in FIGS. 5A and 5B, BP3AS2 was again inhibitory, resulting in
levels of IGFBP-3 of approximately 50% of the most non-specifically
inhibitory control oligonucleotide, the randomised equivalent of
BP3AS2. The other control oligonucleotides caused no reduction in
IGFBP-3 levels at 0.5 .mu.M, compared to untreated cells. Of
possible significance is the fact that this control
oligonucleotide, BP3AS2NS, like BP3AS2 itself, has the highest
potential T.sub.m of the three control oligonucleotides used in
this experiment, enhancing the probability of non-specific base
pairing with ron-target mRNAs. However, the lack of inhibition of
IGFBP4 secretion by BP3AS2 suggests that this oligonucleotide is
selective even compared with the most closely related protein
likely to be present in this cell line.
EXAMPLE 6
Antisense Oligonucleotides of IGFBP2
[0056] Antisense oligonucleotides to IGFBP2 may be selected from
molecules capable of interacting with one or more of the following
sense oligonucleotides:
4 ATTCGGGGCGAGGGA AAGAAGCGGAGGAGG CCCGCTCGCAGGGCC TTCGGGGCGAGGGAG
AGAAGCGGAGGAGGC CCGCTCGCAGGGCCG TCGGGGCGAGGGAGG GAAGCGGAGGAGGCG
CGCTCGCAGGGCCGT CGGGGCGAGGGAGGA AAGCGGAGGAGGCGG GCTCGCAGGGCCGTG
GGGGCGAGGGAGGAG AGCGGAGGAGGCGGC CTCGCAGGGCCGTGC GGGCGAGGGAGGAGG
GCGGAGGAGGCGGCT TCGCAGGGCCGTGCA GGCGAGGGAGGAGGA CGGAGGAGGCGGCTC
CGCAGGGCCGTGCAC GCGAGGGAGGAGGAA GGAGGAGGCGGCTCC GCAGGGCCGTGCACC
CGAGGGAGGAGGAAG GAGGAGGCGGCTCCC CAGGGCCGTGCACCT GAGGGAGGAGGAAGA
AGGAGGCGGCTCCCG AGGGCCGTGCACCTG AGGGAGGAGGAAGAA GGAGGCGGCTCCCGC
GGGCCGTGCACCTGC GGGAGGAGGAAGAAG GAGGCGGCTCCCGCT GGCCGTGCACCTGCC
GGAGGAGGAAGAAGC AGGCGGCTCCCGCTC GCCGTGCACCTGCCC GAGGAGGAAGAAGCG
GGCGGCTCCCGCTCG CCGTGCACCTGCCCG AGGAGGAAGAAGCGG GCGGCTCCCGCTCGC
CGTGCACCTGCCCGC GGAGGAAGAAGCGGA CGGCTCCCGCTCGCA GTGCACCTGCCCGCC
GAGGAAGAAGCGGAG GGCTCCCGCTCGCAG TGCACCTGCCCGCCC AGGAAGAAGCGGAGG
GCTCCCGCTCGCAGG GCACCTGCCCGCCCG GGAAGAAGCGGAGGA CTCCCGCTCGCAGGG
CACCTGCCCGCCCGC GAAGAAGCGGAGGAG TCCCGCTCGCAGGGC ACCTGCCCGCCCGCC
CCTGCCCGCCCGCCC CATGCTGCCGAGAGT CGCTGCTGCCGCTGC CTGCCCGCCCGCCCG
ATGCTGCCGAGAGTG GCTGCTGCCGCTGCT TGCCCGCCCGCCCGC TGCTGCCGAGAGTGG
CTGCTGCCGCTGCTG GCCCGCCCGCCCGCT GCTGCCGAGAGTGGG TGCTGCCGCTGCTGC
CCCGCCCGCCCGCTC CTGCCGAGAGTGGGC GCTGCCGCTGCTGCT CCGCCCGCCCGCTCG
TGCCGAGAGTGGGCT CTGCCGCTGCTGCTG CGCCCGCCCGCTCGC GCCGAGAGTGGGCTG
TGCCGCTGCTGCTGC GCCCGCCCGCTCGCT CCGAGAGTGGGCTGC GCCGCTGCTGCTGCT
CCCGCCCGCTCGCTC CGAGAGTGGGCTGCC CCGCTGCTGCTGCTG CCGCCCGCTCGCTCG
GAGAGTGGGCTGCCC CGCTGCTGCTGCTGC CGCCCGCTCGCTCGC AGAGTGGGCTGCCCC
GCTGCTGCTGCTGCT GCCCGCTCGCTCGCT GAGTGGGCTGCCCCG CTGCTGCTGCTGCTA
CCCGCTCGCTCGCTC AGTGGGCTGCCCCGC TGCTGCTGCTGCTAC CCGCTCGCTCGCTCG
GTGGGCTGCCCCGCG GCTGCTGCTGCTACT CGCTCGCTCGCTCGC TGGGCTGCCCCGCGC
CTGCTGCTGCTACTG GCTCGCTCGCTCGCC GGGCTGCCCCGCGCT TGCTGCTGCTACTGG
CTCGCTCGCTCGCCC GGCTGCCCCGCGCTG GCTGCTGCTACTGGG TCGCTCGCTCGCCCG
GCTGCCCCGCGCTGC CTGCTGCTACTGGGC CGCTCGCTCGCCCGC CTGCCCCGCGCTGCC
TGCTGCTACTGGGCG GCTCGCTCGCCCGCC TGCCCCGCGCTGCCG GCTGCTACTGGGCGC
CTCGCTCGCCCGCCG GCCCCGCGCTGCCGC CTGCTACTGGGCGCG TCGCTCGCCCGCCGC
CCCCGCGCTGCCGCT TGCTACTGGGCGCGA CGCTCGCCCGCCGCG CCCGCGCTGCCGCTG
GCTACTGGGCGCGAG GCTCGCCCGCCGCGC CCGCGCTGCCGCTGC CTACTGGGCGCGAGT
CTCGCCCGCCGCGCC CGCGCTGCCGCTGCC TACTGGGCGCGAGTG TCGCCCGCCGCGCCG
GCGCTGCCGCTGCCG ACTGGGCGCGAGTGG CGCCCGCCGCGCCGC CGCTGCCGCTGCCGC
CTGGGCGCGAGTGGC GCCCGCCGCGCCGCG GCTGCCGCTGCCGCC TGGGCGCGAGTGGCG
CCCGCCGCGCCGCGC CTGCCGCTGCCGCCG GGGCGCGAGTGGCGG CCGCCGCGCCGCGCT
TGCCGCTGCCGCCGC GGCGCGAGTGGCGGC CGCCGCGCCGCGCTG GCCGCTGCCGCCGCC
GCGCGAGTGGCGGCG GCCGCGCCGCGCTGC CCGCTGCCGCCGCCG CGCGAGTGGCGGCGG
CCGCGCCGCGCTGCC CGCTGCCGCCGCCGC GCGAGTGGCGGCGGC CGCGCCGCGCTGCCG
GCTGCCGCCGCCGCC CGAGTGGCGGCGGCG GCGCCGCGCTGCCGA CTGCCGCCGCCGCCG
GAGTGGCGGCGGCGG CGCCGCGCTGCCGAC TGCCGCCGCCGCCGC AGTGGCGGCGGCGGC
GCCGCGCTGCCGACC GCCGCCGCCGCCGCT GTGGCGGCGGCGGCG CCGCGCTGCCGACCG
CCGCCGCCGCCGCTG TGGCGGCGGCGGCGG CGCGCTGCCGACCGC CGCCGCCGCCGCTGC
GGCGGCGGCGGCGGG GCGCTGCCGACCGCC GCCGCCGCCGCTGCT GCGGCGGCGGCGGGG
CGCTGCCGACCGCCA CCGCCGCCGCTGCTG CGGCGGCGGCGGGGC GCTGCCGACCGCCAG
CGCCGCCGCTGCTGC GGCGGCGGCGGGGCG CTGCCGACCGCCAGC GCCGCCGCTGCTGCC
GCGGCGGCGGGGCGC TGCCGACCGCCAGCA CCGCCGCTGCTGCCG CGGCGGCGGGGCGCG
GCCGACCGCCAGCAT CGCCGCTGCTGCCGC GGCGGCGGGGCGCGC CCGACCGCCAGCATG
GCCGCTGCTGCCGCT GCGGCGGGGCGCGCG CGACCGCCAGCATGC CCGCTGCTGCCGCTG
CGGCGGGGCGCGCGC GACCGCCAGCATGCT CGCTGCTGCCGCTGC GGCGGGGCGCGCGCG
ACCGCCAGCATGCTG GCTGCTGCCGCTGCT GCGGGGCGCGCGCGG CCGCCAGCATGCTGC
CTGCTGCCGCTGCTG CGGGGCGCGCGCGGA CGCCAGCATGCTGCC TGCTGCCGCTGCTGC
GGGGCGCGCGCGGAG GCCAGCATGCTGCCG GCTGCCGCTGCTGCC GGGCGCGCGCGGAGG
CCAGCATGCTGCCGA CTGCCGCTGCTGCCG GGCGCGCGCGGAGGT CAGCATGCTGCCGAG
TGCCGCTGCTGCCGC GCGCGCGCGGAGGTG AGCATGCTGCCGAGA GCCGCTGCTGCCGCT
CGCGCGCGGAGGTGC GCATGCTGCCGAGAG CCGCTGCTGCCGCTG GCGCGCGGAGGTGCT
CGCGCGGAGGTGCTG CGGGCCCCCGCCGGT GCATGCCATGCGCGG GCGCGGAGGTGCTGT
GGGCCCCCGCCGGTT CATGCCATGCGCGGA CGCGGAGGTGCTGTT GGCCCCCGCCGGTTG
ATGCCATGCGCGGAG GCGGAGGTGCTGTTC GCCCCCGCCGGTTGC TGCCATGCGCGGAGC
CGGAGGTGCTGTTCC CCCCCGCCGGTTGCG GCCATGCGCGGAGCT GGAGGTGCTGTTCCG
CCCCGCCGGTTGCGC CCATGCGCGGAGCTC GAGGTGCTGTTCCGC CCCGCCGGTTGCGCC
CATGCGCGGAGCTCG AGGTGCTGTTCCGCT CCGCCGGTTGCGCCG ATGCGCGGAGCTCGT
GGTGCTGTTCCGCTG CGCCGGTTGCGCCGC TGCGCGGAGCTCGTC GTGCTGTTCCGCTGC
GCCGGTTGCGCCGCC GCGCGGAGCTCGTCC TGCTGTTCCGCTGCC CCGGTTGCGCCGCCC
CGCGGAGCTCGTCCG GCTGTTCCGCTGCCC CGGTTGCGCCGCCCG GCGGAGCTCGTCCGG
CTGTTCCGCTGCCCG GGTTGCGCCGCCCGC CGGAGCTCGTCCGGG TGTTCCGCTGCCCGC
GTTGCGCCGCCCGCC GGAGCTCGTCCGGGA GTTCCGCTGCCCGCC TTGCGCCGCCCGCCG
GAGCTCGTCCGGGAG TTCCGCTGCCCGCCC TGCGCCGCCCGCCGC AGCTCGTCCGGGAGC
TCCGCTGCCCGCCCT GCGCCGCCCGCCGCG GCTCGTCCGGGAGCC CCGCTGCCCGCCCTG
CGCCGCCCGCCGCGG CTCGTCCGGGAGCCG CGCTGCCCGCCCTGC GCCGCCCGCCGCGGT
TCGTCCGGGAGCCGG GCTGCCCGCCCTGCA CCGCCCGCCGCGGTG CGTCCGGGAGCCGGG
CTGCCCGCCCTGCAC CGCCCGCCGCGGTGG GTCCGGGAGCCGGGC TGCCCGCCCTGCACA
GCCCGCCGCGGTGGC TCCGGGAGCCGGGCT GCCCGCCCTGCACAC CCCGCCGCGGTGGCC
CCGGGAGCCGGGCTG CCCGCCCTGCACACC CCGCCGCGGTGGCCG CGGGAGCCGGGCTGC
CCGCCCTGCACACCC CGCCGCGGTGGCCGC GGGAGCCGGGCTGCG CGCCCTGCACACCCG
GCCGCGGTGGCCGCA GGAGCCGGGCTGCGG GCCCTGCACACCCGA CCGCGGTGGCCGCAG
GAGCCGGGCTGCGGC CCCTGCACACCCGAG CGCGGTGGCCGCAGT AGCCGGGCTGCGGCT
CCTGCACACCCGAGC GCGGTGGCCGCAGTG GCCGGGCTGCGGCTG CTGCACACCCGAGCG
CGGTGGCCGCAGTGG CCGGGCTGCGGCTGC TGCACACCCGAGCGC GGTGGCCGCAGTGGC
CGGGCTGCGGCTGCT GCACACCCGAGCGCC GTGGCCGCAGTGGCC GGGCTGCGGCTGCTG
CACACCCGAGCGCCT TGGCCGCAGTGGCCG GGCTGCGGCTGCTGC ACACCCGAGCGCCTG
GGCCGCAGTGGCCGG GCTGCGGCTGCTGCT CACCCGAGCGCCTGG GCCGCAGTGGCCGGA
CTGCGGCTGCTGCTC ACCCGAGCGCCTGGC CCGCAGTGGCCGGAG TGCGGCTGCTGCTCG
CCCGAGCGCCTGGCC CGCAGTGGCCGGAGG GCGGCTGCTGCTCGG CCGAGCGCCTGGCCG
GCAGTGGCCGGAGGC CGGCTGCTGCTCGGT CGAGCGCCTGGCCGC CAGTGGCCGGAGGCG
GGCTGCTGCTCGGTG GAGCGCCTGGCCGCC AGTGGCCGGAGGCGC GCTGCTGCTCGGTGT
AGCGCCTGGCCGCCT GTGGCCGGAGGCGCC CTGCTGCTCGGTGTG GCGCCTGGCCGCCTG
TGGCCGGAGGCGCCC TGCTGCTCGGTGTGC CGCCTGGCCGCCTGC GGCCGGAGGCGCCCG
GCTGCTCGGTGTGCG GCCTGGCCGCCTGCG GCCGGAGGCGCCCGC CTGCTCGGTGTGCGC
CCTGGCCGCCTGCGG CCGGAGGCGCCCGCA TGCTCGGTGTGCGCC CTGGCCGCCTGCGGG
CGGAGGCGCCCGCAT GCTCGGTGTGCGCCC TGGCCGCCTGCGGGC GGAGGCGCCCGCATG
CTCGGTGTGCGCCCG GGCCGCCTGCGGGCC GAGGCGCCCGCATGC TCGGTGTGCGCCCGG
GCCGCCTGCGGGCCC AGGCGCCCGCATGCC CGGTGTGCGCCCGGC CCGCCTGCGGGCCCC
GGCGCCCGCATGCCA GGTGTGCGCCCGGCT CGCCTGCGGGCCCCC GCGCCCGCATGCCAT
GTGTGCGCCCGGCTG GCCTGCGGGCCCCCG CGCCCGCATGCCATG TGTGCGCCCGGCTGG
CCTGCGGGCCCCCGC GCCCGCATGCCATGC GTGCGCCCGGCTGGA CTGCGGGCCCCCGCC
CCCGCATGCCATGCG TGCGCCCGGCTGGAG TGCGGGCCCCCGCCG CCGCATGCCATGCGC
GCGCCCGGCTGGAGG GCGGGCCCCCGCCGG CGCATGCCATGCGCG CGCCCGGCTGGAGGG
GCCCGGCTGGAGGGC GCGCTGCTATCCCCA AGGGCACTTGTGAGA CCCGGCTGGAGGGCG
CGCTGCTATCCCCAC GGGCACTTGTGAGAA CCGGCTGGAGGGCGA GCTGCTATCCCCACC
GGCACTTGTGAGAAG CGGCTGGAGGGCGAG CTGCTATCCCCACCC GCACTTGTGAGAAGC
GGCTGGAGGGCGAGG TGCTATCCCCACCCG CACTTGTGAGAAGCG GCTGGAGGGCGAGGC
GCTATCCCCACCCGG ACTTGTGAGAAGCGC CTGGAGGGCGAGGCG CTATCCCCACCCGGG
CTTGTGAGAAGCGCC TGGAGGGCGAGGCGT TATCCCCACCCGGGC TTGTGAGAAGCGCCG
GGAGGGCGAGGCGTG ATCCCCACCCGGGCT TGTGAGAAGCGCCGG GAGGGCGAGGCGTGC
TCCCCACCCGGGCTC GTGAGAAGCGCCGGG AGGGCGAGGCGTGCG CCCCACCCGGGCTCC
TGAGAAGCGCCGGGA GGGCGAGGCGTGCGG CCCACCCGGGCTCCG GAGAAGCGCCGGGAC
GGCGAGGCGTGCGGC CCACCCGGGCTCCGA AGAAGCGCCGGGACG GCGAGGCGTGCGGCG
CACCCGGGCTCCGAG GAAGCGCCGGGACGC CGAGGCGTGCGGCGT ACCCGGGCTCCGAGC
AAGCGCCGGGACGCC GAGGCGTGCGGCGTC CCCGGGCTCCGAGCT AGCGCCGGGACGCCG
AGGCGTGCGGCGTCT CCGGGCTCCGAGCTG GCGCCGGGACGCCGA GGCGTGCGGCGTCTA
CGGGCTCCGAGCTGC CGCCGGGACGCCGAG GCGTGCGGCGTCTAC GGGCTCCGAGCTGCC
GCCGGGACGCCGAGT CGTGCGGCGTCTACA GGCTCCGAGCTGCCC CCGGGACGCCGAGTA
GTGCGGCGTCTACAC GCTCCGAGCTGCCCC CGGGACGCCGAGTAT TGCGGCGTCTACACC
CTCCGAGCTGCCCCT GGGACGCCGAGTATG GCGGCGTCTACACCC TCCGAGCTGCCCCTG
GGACGCCGAGTATGG CGGCGTCTACACCCC CCGAGCTGCCCCTGC GACGCCGAGTATGGC
GGCGTCTACACCCCG CGAGCTGCCCCTGCA ACGCCGAGTATGGCG GCGTCTACACCCCGC
GAGCTGCCCCTGCAG CGCCGAGTATGGCGC CGTCTACACCCCGCG AGCTGCCCCTGCAGG
GCCGAGTATGGCGCC GTCTACACCCCGCGC GCTGCCCCTGCAGGC CCGAGTATGGCGCCA
TCTACACCCCGCGCT CTGCCCCTGCAGGCG CGAGTATGGCGCCAG CTACACCCCGCGCTG
TGCCCCTGCAGGCGC GAGTATGGCGCCAGC TACACCCCGCGCTGC GCCCCTGCAGGCGCT
AGTATGGCGCCAGCC ACACCCCGCGCTGCG CCCCTGCAGGCGCTG GTATGGCGCCAGCCC
CACCCCGCGCTGCGG CCCTGCAGGCGCTGG TATGGCGCCAGCCCG ACCCCGCGCTGCGGC
CCTGCAGGCGCTGGT ATGGCGCCAGCCCGG CCCCGCGCTGCGGCC CTGCAGGCGCTGGTC
TGGCGCCAGCCCGGA CCCGCGCTGCGGCCA TGCAGGCGCTGGTCA GGCGCCAGCCCGGAG
CCGCGCTGCGGCCAG GCAGGCGCTGGTCAT GCGCCAGCCCGGAGC CGCGCTGCGGCCAGG
CAGGCGCTGGTCATG CGCCAGCCCGGAGCA GCGCTGCGGCCAGGG AGGCGCTGGTCATGG
GCCAGCCCGGAGCAG CGCTGCGGCCAGGGG GGCGCTGGTCATGGG CCAGCCCGGAGCAGG
GCTGCGGCCAGGGGC GCGCTGGTCATGGGC CAGCCCGGAGCAGGT CTGCGGCCAGGGGCT
CGCTGGTCATGGGCG AGCCCGGAGCAGGTT TGCGGCCAGGGGCTG GCTGGTCATGGGCGA
GCCCGGAGCAGGTTG GCGGCCAGGGGCTGC CTGGTCATGGGCGAG CCCGGAGCAGGTTGC
CGGCCAGGGGCTGCG TGGTCATGGGCGAGG CCGGAGCAGGTTGCA GGCCAGGGGCTGCGC
GGTCATGGGCGAGGG CGGAGCAGGTTGCAG GCCAGGGGCTGCGCT GTCATGGGCGAGGGC
GGAGCAGGTTGCAGA CCAGGGGCTGCGCTG TCATGGGCGAGGGCA GAGCAGGTTGCAGAC
CAGGGGCTGCGCTGC CATGGGCGAGGGCAC AGCAGGTTGCAGACA AGGGGCTGCGCTGCT
ATGGGCGAGGGCACT GCAGGTTGCAGACAA GGGGCTGCGCTGCTA TGGGCGAGGGCACTT
CAGGTTGCAGACAAT GGGCTGCGCTGCTAT GGGCGAGGGCACTTG AGGTTGCAGACAATG
GGCTGCGCTGCTATC GGCGAGGGCACTTGT GGTTGCAGACAATGG GCTGCGCTGCTATCC
GCGAGGGCACTTGTG GTTGCAGACAATGGC CTGCGCTGCTATCCC CGAGGGCACTTGTGA
TTGCAGACAATGGCG TGCGCTGCTATCCCC GAGGGCACTTGTGAG TGCAGACAATGGCGA
GCAGACAATGGCGAT CACCATGAACATGTT GTATGAAGGAGCTGG CAGACAATGGCGATG
ACCATGAACATGTTG TATGAAGGAGCTGGC AGACAATGGCGATGA CCATGAACATGTTGG
ATGAAGGAGCTGGCC GACAATGGCGATGAC CATGAACATGTTGGG TGAAGGAGCTGGCCG
ACAATGGCGATGACC ATGAACATGTTGGGC GAAGGAGCTGGCCGT CAATGGCGATGACCA
TGAACATGTTGGGCG AAGGAGCTGGCCGTG AATGGCGATGACCAC GAACATGTTGGGCGG
AGGAGCTGGCCGTGT ATGGCGATGACCACT AACATGTTGGGCGGG GGAGCTGGCCGTGTT
TGGCGATGACCACTC ACATGTTGGGCGGGG GAGCTGGCCGTGTTC GGCGATGACCACTCA
CATGTTGGGCGGGGG AGCTGGCCGTGTTCC GCGATGACCACTCAG ATGTTGGGCGGGGGA
GCTGGCCGTGTTCCG CGATGACCACTCAGA TGTTGGGCGGGGGAG CTGGCCGTGTTCCGG
GATGACCACTCAGAA GTTGGGCGGGGGAGG TGGCCGTGTTCCGGG ATGACCACTCAGAAG
TTGGGCGGGGGAGGC GGCCGTGTTCCGGGA TGACCACTCAGAAGG TGGGCGGGGGAGGCA
GCCGTGTTCCGGGAG GACCACTCAGAAGGA GGGCGGGGGAGGCAG CCGTGTTCCGGGAGA
ACCACTCAGAAGGAG GGCGGGGGAGGCAGT CGTGTTCCGGGAGAA CCACTCAGAAGGAGG
GCGGGGGAGGCAGTG GTGTTCCGGGAGAAG CACTCAGAAGGAGGC CGGGGGAGGCAGTGC
TGTTCCGGGAGAAGG ACTCAGAAGGAGGCC GGGGGAGGCAGTGCT GTTCCGGGAGAAGGT
CTCAGAAGGAGGCCT GGGGAGGCAGTGCTG TTCCGGGAGAAGGTC TCAGAAGGAGGCCTG
GGGAGGCAGTGCTGG TCCGGGAGAAGGTCA CAGAAGGAGGCCTGG GGAGGCAGTGCTGGC
CCGGGAGAAGGTCAC AGAAGGAGGCCTGGT GAGGCAGTGCTGGCC CGGGAGAAGGTCACT
GAAGGAGGCCTGGTG AGGCAGTGCTGGCCG GGGAGAAGGTCACTG AAGGAGGCCTGGTGG
GGCAGTGCTGGCCGG GGAGAAGGTCACTGA AGGAGGCCTGGTGGA GCAGTGCTGGCCGGA
GAGAAGGTCACTGAG GGAGGCCTGGTGGAG CAGTGCTGGCCGGAA AGAAGGTCACTGAGC
GAGGCCTGGTGGAGA AGTGCTGGCCGGAAG GAAGGTCACTGAGCA AGGCCTGGTGGAGAA
GTGCTGGCCGGAAGC AAGGTCACTGAGCAG GGCCTGGTGGAGAAC TGCTGGCCGGAAGCC
AGGTCACTGAGCAGC GCCTGGTGGAGAACC GCTGGCCGGAAGCCC GGTCACTGAGCAGCA
CCTGGTGGAGAACCA CTGGCCGGAAGCCCC GTCACTGAGCAGCAC CTGGTGGAGAACCAC
TGGCCGGAAGCCCCT TCACTGAGCAGCACC TGGTGGAGAACCACG GGCCGGAAGCCCCTC
CACTGAGCAGCACCG GGTGGAGAACCACGT GCCGGAAGCCCCTCA ACTGAGCAGCACCGG
GTGGAGAACCACGTG CCGGAAGCCCCTCAA CTGAGCAGCACCGGC TGGAGAACCACGTGG
CGGAAGCCCCTCAAG TGAGCAGCACCGGCA GGAGAACCACGTGGA GGAAGCCCCTCAAGT
GAGCAGCACCGGCAG GAGAACCACGTGGAC GAAGCCCCTCAAGTC AGCAGCACCGGCAGA
AGAACCACGTGGACA AAGCCCCTCAAGTCG GCAGCACCGGCAGAT GAACCACGTGGACAG
AGCCCCTCAAGTCGG CAGCACCGGCAGATG AACCACGTGGACAGC GCCCCTCAAGTCGGG
AGCACCGGCAGATGG ACCACGTGGACAGCA CCCCTCAAGTCGGGT GCACCGGCAGATGGG
CCACGTGGACAGCAC CCCTCAAGTCGGGTA CACCGGCAGATGGGC CACGTGGACAGCACC
CCTCAAGTCGGGTAT ACCGGCAGATGGGCA ACGTGGACAGCACCA CTCAAGTCGGGTATG
CCGGCAGATGGGCAA CGTGGACAGCACCAT TCAAGTCGGGTATGA CGGCAGATGGGCAAG
GTGGACAGCACCATG CAAGTCGGGTATGAA GGCAGATGGGCAAGG TGGACAGCACCATGA
AAGTCGGGTATGAAG GCAGATGGGCAAGGG GGACAGCACCATGAA AGTCGGGTATGAAGG
CAGATGGGCAAGGGT GACAGCACCATGAAC GTCGGGTATGAAGGA AGATGGGCAAGGGTG
ACAGCACCATGAACA TCGGGTATGAAGGAG GATGGGCAAGGGTGG CAGCACCATGAACAT
CGGGTATGAAGGAGC ATGGGCAAGGGTGGC AGCACCATGAACATG GGGTATGAAGGAGCT
TGGGCAAGGGTGGCA GCACCATGAACATGT GGTATGAAGGAGCTG GGGCAAGGGTGGCAA
GGCAAGGGTGGCAAG CCCTGCCAGGACTCC CCATGCGCCTTCCGG GCAAGGGTGGCAAGC
CCTGCCAGGACTCCC CATGCGCCTTCCGGA CAAGGGTGGCAAGCA CTGCCAGGACTCCCT
ATGCGCCTTCCGGAT AAGGGTGGCAAGCAT TGCCAGGACTCCCTG TGCGCCTTCCGGATG
AGGGTGGCAAGCATC GCCAGGACTCCCTGC GCGCCTTCCGGATGA GGGTGGCAAGCATCA
CCAGGACTCCCTGCC CGCCTTCCGGATGAG GGTGGCAAGCATCAC CAGGACTCCCTGCCA
GCCTTCCGGATGAGC
GTGGCAAGCATCACC AGGACTCCCTGCCAA CCTTCCGGATGAGCG TGGCAAGCATCACCT
GGACTCCCTGCCAAC CTTCCGGATGAGCGG GGCAAGCATCACCTT GACTCCCTGCCAACA
TTCCGGATGAGCGGG GCAAGCATCACCTTG ACTCCCTGCCAACAG TCCGGATGAGCGGGG
CAAGCATCACCTTGG CTCCCTGCCAACAGG CCGGATGAGCGGGGC AAGCATCACCTTGGC
TCCCTGCCAACAGGA CGGATGAGCGGGGCC AGCATCACCTTGGCC CCCTGCCAACAGGAA
GGATGAGCGGGGCCC GCATCACCTTGGCCT CCTGCCAACAGGAAC GATGAGCGGGGCCCT
CATCACCTTGGCCTG CTGCCAACAGGAACT ATGAGCGGGGCCCTC ATCACCTTGGCCTGG
TGCCAACAGGAACTG TGAGCGGGGCCCTCT TCACCTTGGCCTGGA GCCAACAGGAACTGG
GAGCGGGGCCCTCTG CACCTTGGCCTGGAG CCAACAGGAACTGGA AGCGGGGCCCTCTGG
ACCTTGGCCTGGAGG CAACAGGAACTGGAC GCGGGGCCCTCTGGA CCTTGGCCTGGAGGA
AACAGGAACTGGACC CGGGGCCCTCTGGAG CTTGGCCTGGAGGAG ACAGGAACTGGACCA
GGGGCCCTCTGGAGC TTGGCCTGGAGGAGC CAGGAACTGGACCAG GGGCCCTCTGGAGCA
TGGCCTGGAGGAGCC AGGAACTGGACCAGG GGCCCTCTGGAGCAC GGCCTGGAGGAGCCC
GGAACTGGACCAGGT GCCCTCTGGAGCACC GCCTGGAGGAGCCCA GAACTGGACCAGGTC
CCCTCTGGAGCACCT CCTGGAGGAGCCCAA AACTGGACCAGGTCC CCTCTGGAGCACCTC
CTGGAGGAGCCCAAG ACTGGACCAGGTCCT CTCTGGAGCACCTCT TGGAGGAGCCCAAGA
CTGGACCAGGTCCTG TCTGGAGCACCTCTA GGAGGAGCCCAAGAA TGGACCAGGTCCTGG
CTGGAGCACCTCTAC GAGGAGCCCAAGAAG GGACCAGGTCCTGGA TGGAGCACCTCTACT
AGGAGCCCAAGAAGC GACCAGGTCCTGGAG GGAGCACCTCTACTC GGAGCCCAAGAAGCT
ACCAGGTCCTGGAGC GAGCACCTCTACTCC GAGCCCAAGAAGCTG CCAGGTCCTGGAGCG
AGCACCTCTACTCCC AGCCCAAGAAGCTGC CAGGTCCTGGAGCGG GCACCTCTACTCCCT
GCCCAAGAAGCTGCG AGGTCCTGGAGCGGA CACCTCTACTCCCTG CCCAAGAAGCTGCGA
GGTCCTGGAGCGGAT ACCTCTACTCCCTGC CCAAGAAGCTGCGAC GTCCTGGAGCGGATC
CCTCTACTCCCTGCA CAAGAAGCTGCGACC TCCTGGAGCGGATCT CTCTACTCCCTGCAC
AAGAAGCTGCGACCA CCTGGAGCGGATCTC TCTACTCCCTGCACA AGAAGCTGCGACCAC
CTGGAGCGGATCTCC CTACTCCCTGCACAT GAAGCTGCGACCACC TGGAGCGGATCTCCA
TACTCCCTGCACATC AAGCTGCGACCACCC GGAGCGGATCTCCAC ACTCCCTGCACATCC
AGCTGCGACCACCCC GAGCGGATCTCCACC CTCCCTGCACATCCC GCTGCGACCACCCCC
AGCGGATCTCCACCA TCCCTGCACATCCCC CTGCGACCACCCCCT GCGGATCTCCACCAT
CCCTGCACATCCCCA TGCGACCACCCCCTG CGGATCTCCACCATG CCTGCACATCCCCAA
GCGACCACCCCCTGC GGATCTCCACCATGC CTGCACATCCCCAAC CGACCACCCCCTGCC
GATCTCCACCATGCG TGCACATCCCCAACT GACCACCCCCTGCCA ATCTCCACCATGCGC
GCACATCCCCAACTG ACCACCCCCTGCCAG TCTCCACCATGCGCC CACATCCCCAACTGT
CCACCCCCTGCCAGG CTCCACCATGCGCCT ACATCCCCAACTGTG CACCCCCTGCCAGGA
TCCACCATGCGCCTT CATCCCCAACTGTGA ACCCCCTGCCAGGAC CCACCATGCGCCTTC
ATCCCCAACTGTGAC CCCCCTGCCAGGACT CACCATGCGCCTTCC TCCCCAACTGTGACA
CCCCTGCCAGGACTC ACCATGCGCCTTCCG CCCCAACTGTGACAA CCCAACTGTGACAAG
CGGGCAGCGTGGGGA GAGCCCCCACCATCC CCAACTGTGACAAGC GGGCAGCGTGGGGAG
AGCCCCCACCATCCG CAACTGTGACAAGCA GGCAGCGTGGGGAGT GCCCCCACCATCCGG
AACTGTGACAAGCAT GCAGCGTGGGGAGTG CCCCCACCATCCGGG ACTGTGACAAGCATG
CAGCGTGGGGAGTGC CCCCACCATCCGGGG CTGTGACAAGCATGG AGCGTGGGGAGTGCT
CCCACCATCCGGGGG TGTGACAAGCATGGC GCGTGGGGAGTGCTG CCACCATCCGGGGGG
GTGACAAGCATGGCC CGTGGGGAGTGCTGG CACCATCCGGGGGGA TGACAAGCATGGCCT
GTGGGGAGTGCTGGT ACCATCCGGGGGGAC GACAAGCATGGCCTG TGGGGAGTGCTGGTG
CCATCCGGGGGGACC ACAAGCATGGCCTGT GGGGAGTGCTGGTGT CATCCGGGGGGACCC
CAAGCATGGCCTGTA GGGAGTGCTGGTGTG ATCCGGGGGGACCCC AAGCATGGCCTGTAC
GGAGTGCTGGTGTGT TCCGGGGGGACCCCG AGCATGGCCTGTACA GAGTGCTGGTGTGTG
CCGGGGGGACCCCGA GCATGGCCTGTACAA AGTGCTGGTGTGTGA CGGGGGGACCCCGAG
CATGGCCTGTACAAC GTGCTGGTGTGTGAA GGGGGGACCCCGAGT ATGGCCTGTACAACC
TGCTGGTGTGTGAAC GGGGGACCCCGAGTG TGGCCTGTACAACCT GCTGGTGTGTGAACC
GGGGACCCCGAGTGT GGCCTGTACAACCTC CTGGTGTGTGAACCC GGGACCCCGAGTGTC
GCCTGTACAACCTCA TGGTGTGTGAACCCC GGACCCCGAGTGTCA CCTGTACAACCTCAA
GGTGTGTGAACCCCA GACCCCGAGTGTCAT CTGTACAACCTCAAA GTGTGTGAACCCCAA
ACCCCGAGTGTCATC TGTACAACCTCAAAC TGTGTGAACCCCAAC CCCCGAGTGTCATCT
GTACAACCTCAAACA GTGTGAACCCCAACA CCCGAGTGTCATCTC TACAACCTCAAACAG
TGTGAACCCCAACAC CCGAGTGTCATCTCT ACAACCTCAAACAGT GTGAACCCCAACACC
CGAGTGTCATCTCTT CAACCTCAAACAGTG TGAACCCCAACACCG GAGTGTCATCTCTTC
AACCTCAAACAGTGC GAACCCCAACACCGG AGTGTCATCTCTTCT ACCTCAAACAGTGCA
AACCCCAACACCGGG GTGTCATCTCTTCTA CCTCAAACAGTGCAA ACCCCAACACCGGGA
TGTCATCTCTTCTAC CTCAAACAGTGCAAG CCCCAACACCGGGAA GTCATCTCTTCTACA
TCAAACAGTGCAAGA CCCAACACCGGGAAG TCATCTCTTCTACAA CAAACAGTGCAAGAT
CCAACACCGGGAAGC CATCTCTTCTACAAT AAACAGTGCAAGATG CAACACCGGGAAGCT
ATCTCTTCTACAATG AACAGTGCAAGATGT AACACCGGGAAGCTG TCTCTTCTACAATGA
ACAGTGCAAGATGTC ACACCGGGAAGCTGA CTCTTCTACAATGAG CAGTGCAAGATGTCT
CACCGGGAAGCTGAT TCTTCTACAATGAGC AGTGCAAGATGTCTC ACCGGGAAGCTGATC
CTTCTACAATGAGCA GTGCAAGATGTCTCT CCGGGAAGCTGATCC TTCTACAATGAGCAG
TGCAAGATGTCTCTG CGGGAAGCTGATCCA TCTACAATGAGCAGC GCAAGATGTCTCTGA
GGGAAGCTGATCCAG CTACAATGAGCAGCA CAAGATGTCTCTGAA GGAAGCTGATCCAGG
TACAATGAGCAGCAG AAGATGTCTCTGAAC GAAGCTGATCCAGGG ACAATGAGCAGCAGG
AGATGTCTCTGAACG AAGCTGATCCAGGGA CAATGAGCAGCAGGA GATGTCTCTGAACGG
AGCTGATCCAGGGAG AATGAGCAGCAGGAG ATGTCTCTGAACGGG GCTGATCCAGGGAGC
ATGAGCAGCAGGAGG TGTCTCTGAACGGGC CTGATCCAGGGAGCC TGAGCAGCAGGAGGC
GTCTCTGAACGGGCA TGATCCAGGGAGCCC GAGCAGCAGGAGGCT TCTCTGAACGGGCAG
GATCCAGGGAGCCCC AGCAGCAGGAGGCTT CTCTGAACGGGCAGC ATCCAGGGAGCCCCC
GCAGCAGGAGGCTTG TCTGAACGGGCAGCG TCCAGGGAGCCCCCA CAGCAGGAGGCTTGC
CTGAACGGGCAGCGT CCAGGGAGCCCCCAC AGCAGGAGGCTTGCG TGAACGGGCAGCGTG
CAGGGAGCCCCCACC GCAGGAGGCTTGCGG GAACGGGCAGCGTGG AGGGAGCCCCCACCA
CAGGAGGCTTGCGGG AACGGGCAGCGTGGG GGGAGCCCCCACCAT AGGAGGCTTGCGGGG
ACGGGCAGCGTGGGG GGAGCCCCCACCATC GGAGGCTTGCGGGGT GAGGCTTGCGGGGTG
GGCGCCCCTGCCCCC GTGGTGGGTGCTGGA AGGCTTGCGGGGTGC GCGCCCCTGCCCCCC
TGGTGGGTGCTGGAG GGCTTGCGGGGTGCA CGCCCCTGCCCCCCG GGTGGGTGCTGGAGG
GCTTGCGGGGTGCAC GCCCCTGCCCCCCGC GTGGGTGCTGGAGGA CTTGCGGGGTGCACA
CCCCTGCCCCCCGCC TGGGTGCTGGAGGAT TTGCGGGGTGCACAC CCCTGCCCCCCGCCC
GGGTGCTGGAGGATT TGCGGGGTGCACACC CCTGCCCCCCGCCCC GGTGCTGGAGGATTT
GCGGGGTGCACACCC CTGCCCCCCGCCCCT GTGCTGGAGGATTTT CGGGGTGCACACCCA
TGCCCCCCGCCCCTC TGCTGGAGGATTTTC GGGGTGCACACCCAG GCCCCCCGCCCCTCT
GCTGGAGGATTTTCC GGGTGCACACCCAGC CCCCCCGCCCCTCTC CTGGAGGATTTTCCA
GGTGCACACCCAGCG CCCCCGCCCCTCTCC TGGAGGATTTTCCAG GTGCACACCCAGCGG
CCCCGCCCCTCTCCA GGAGGATTTTCCAGT TGCACACCCAGCGGA CCCGCCCCTCTCCAA
GAGGATTTTCCAGTT GCACACCCAGCGGAT CCGCCCCTCTCCAAA AGGATTTTCCAGTTC
CACACCCAGCGGATG CGCCCCTCTCCAAAC GGATTTTCCAGTTCT ACACCCAGCGGATGC
GCCCCTCTCCAAACA GATTTTCCAGTTCTG CACCCAGCGGATGCA CCCCTCTCCAAACAC
ATTTTCCAGTTCTGA ACCCAGCGGATGCAG CCCTCTCCAAACACC TTTTCCAGTTCTGAC
CCCAGCGGATGCAGT CCTCTCCAAACACCG TTTCCAGTTCTGACA CCAGCGGATGCAGTA
CTCTCCAAACACCGG TTCCAGTTCTGACAC CAGCGGATGCAGTAG TCTCCAAACACCGGC
TCCAGTTCTGACACA AGCGGATGCAGTAGA CTCCAAACACCGGCA CCAGTTCTGACACAC
GCGGATGCAGTAGAC TCCAAACACCGGCAG CAGTTCTGACACACG CGGATGCAGTAGACC
CCAAACACCGGCAGA AGTTCTGACACACGT GGATGCAGTAGACCG CAAACACCGGCAGAA
GTTCTGACACACGTA GATGCAGTAGACCGC AAACACCGGCAGAAA TTCTGACACACGTAT
ATGCAGTAGACCGCA AACACCGGCAGAAAA TCTGACACACGTATT TGCAGTAGACCGCAG
ACACCGGCAGAAAAC CTGACACACGTATTT GCAGTAGACCGCAGC CACCGGCAGAAAACG
TGACACACGTATTTA CAGTAGACCGCAGCC ACCGGCAGAAAACGG GACACACGTATTTAT
AGTAGACCGCAGCCA CCGGCAGAAAACGGA ACACACGTATTTATA GTAGACCGCAGCCAG
CGGCAGAAAACGGAG CACACGTATTTATAT TAGACCGCAGCCAGC GGCAGAAAACGGAGA
ACACGTATTTATATT AGACCGCAGCCAGCC GCAGAAAACGGAGAG CACGTATTTATATTT
GACCGCAGCCAGCCG CAGAAAACGGAGAGT ACGTATTTATATTTG ACCGCAGCCAGCCGG
AGAAAACGGAGAGTG CGTATTTATATTTGG CCGCAGCCAGCCGGT GAAAACGGAGAGTGC
GTATTTATATTTGGA CGCAGCCAGCCGGTG AAAACGGAGAGTGCT TATTTATATTTGGAA
GCAGCCAGCCGGTGC AAACGGAGAGTGCTT ATTTATATTTGGAAA CAGCCAGCCGGTGCC
AACGGAGAGTGCTTG TTTATATTTGGAAAG AGCCAGCCGGTGCCT ACGGAGAGTGCTTGG
TTATATTTGGAAAGA GCCAGCCGGTGCCTG CGGAGAGTGCTTGGG TATATTTGGAAAGAG
CCAGCCGGTGCCTGG GGAGAGTGCTTGGGT ATATTTGGAAAGAGA CAGCCGGTGCCTGGC
GAGAGTGCTTGGGTG TATTTGGAAAGAGAC AGCCGGTGCCTGGCG AGAGTGCTTGGGTGG
ATTTGGAAAGAGACC GCCGGTGCCTGGCGC GAGTGCTTGGGTGGT TTTGGAAAGAGACCA
CCGGTGCCTGGCGCC AGTGCTTGGGTGGTG TTGGAAAGAGACCAG CGGTGCCTGGCGCCC
GTGCTTGGGTGGTGG TGGAAAGAGACCAGC GGTGCCTGGCGCCCC TGCTTGGGTGGTGGG
GGAAAGAGACCAGCA GTGCCTGGCGCCCCT GCTTGGGTGGTGGGT GAAAGAGACCAGCAC
TGCCTGGCGCCCCTG CTTGGGTGGTGGGTG AAAGAGACCAGCACC GCCTGGCGCCCCTGC
TTGGGTGGTGGGTGC AAGAGACCAGCACCG CCTGGCGCCCCTGCC TGGGTGGTGGGTGCT
AGAGACCAGCACCGA CTGGCGCCCCTGCCC GGGTGGTGGGTGCTG GAGACCAGCACCGAG
TGGCGCCCCTGCCCC GGTGGTGGGTGCTGG AGACCAGCACCGAGC GACCAGCACCGAGCT
CACCTGCTCCTTCTT GGGTACAGGTTTGGG ACCAGCACCGAGCTC ACCTGCTCCTTCTTG
GGTACAGGTTTGGGG CCAGCACCGAGCTCG CCTGCTCCTTCTTGC GTACAGGTTTGGGGA
CAGCACCGAGCTCGG CTGCTCCTTCTTGCT TACAGGTTTGGGGAG AGCACCGAGCTCGGC
TGCTCCTTCTTGCTT ACAGGTTTGGGGAGG GCACCGAGCTCGGCA GCTCCTTCTTGCTTT
CAGGTTTGGGGAGGG CACCGAGCTCGGCAC CTCCTTCTTGCTTTC AGGTTTGGGGAGGGG
ACCGAGCTCGGCACC TCCTTCTTGCTTTCC GGTTTGGGGAGGGGG CCGAGCTCGGCACCT
CCTTCTTGCTTTCCC CTTTGGGGAGGGGGA CGAGCTCGGCACCTC CTTCTTGCTTTCCCC
TTTGGGGAGGGGGAA GAGCTCGGCACCTCC TTCTTGCTTTCCCCG TTGGGGAGGGGGAAG
AGCTCGGCACCTCCC TCTTGCTTTCCCCGC TGGGGAGGGGGAAGA GCTCGGCACCTCCCC
CTTGCTTTCCCCGGG GGGGAGGGGGAAGAG CTCGGCACCTCCCCG TTGCTTTCCCCGGGG
GGGAGGGGGAAGAGA TCGGCACCTCCCCGG TGCTTTCCCCGGGGG GGAGGGGGAAGAGAA
CGGCACCTCCCCGGC GCTTTCCCCGGGGGA GAGGGGGAAGAGAAA GGCACCTCCCCGGCC
CTTTCCCCGGGGGAG AGGGGGAAGAGAAAT GCACCTCCCCGGCCT TTTCCCCGGGGGAGG
GGGGGAAGAGAAATT CACCTCCCCGGCCTC TTCCCCGGGGGAGGA GGGGAAGAGAAATTT
ACCTCCCCGGCCTCT TCCCCGGGGGAGGAA GGGAAGAGAAATTTT CCTCCCCGGCCTCTC
CCCCGGGGGAGGAAG GGAAGAGAAATTTTT CTCCCCGGCCTCTCT CCCGGGGGAGGAAGG
GAAGAGAAATTTTTA TCCCCGGCCTCTCTC CCGGGGGAGGAAGGG AAGAGAAATTTTTAT
CCCCGGCCTCTCTCT CGGGGGAGGAAGGGG AGAGAAATTTTTATT CCCGGCCTCTCTCTT
GGGGGAGGAAGGGGG GAGAAATTTTTATTT CCGGCCTCTCTCTTC GGGGAGGAAGGGGGT
AGAAATTTTTATTTT CGGCCTCTCTCTTCC GGGAGGAAGGGGGTT GAAATTTTTATTTTT
GGCCTCTCTCTTCCC GGAGGAAGGGGGTTG AAATTTTTATTTTTG GCCTCTCTCTTCCCA
GAGGAAGGGGGTTGT AATTTTTATTTTTGA CCTCTCTCTTCCCAG AGGAAGGGGGTTGTG
ATTTTTATTTTTGAA CTCTCTCTTCCCAGC GGAAGGGGGTTGTGG TTTTTATTTTTGAAC
TCTCTCTTCCCAGCT GAAGGGGGTTGTGGT TTTTATTTTTGAACC CTCTCTTCCCAGCTG
AAGGGGGTTGTGGTC TTTATTTTTGAACCC TCTCTTCCCAGCTGC AGGGGGTTGTGGTCG
TTATTTTTGAACCCC CTCTTCCCAGCTGCA GGGGGTTGTGGTCGG TATTTTTGAACCCCT
TCTTCCCAGCTGCAG GGGGTTGTGGTCGGG ATTTTTGAACCCCTG CTTCCCAGCTGCAGA
GGGTTGTGGTCGGGG TTTTTGAACCCCTGT TTCCCAGCTGCAGAT GGTTGTGGTCGGGGA
TTTTGAACCCCTGTG TCCCAGCTGCAGATG GTTGTGGTCGGGGAG TTTGAACCCCTGTGT
CCCAGCTGCAGATGC TTGTGGTCGGGGAGC TTGAACCCCTGTGTC CCAGCTGCAGATGCC
TGTGGTCGGGGAGCT TGAACCCCTGTGTCC CAGCTGCAGATGCCA GTGGTCGGGGAGCTG
GAACCCCTGTGTCCC AGCTGCAGATGCCAC TGGTCGGGGAGCTGG AACCCCTGTGTCCCT
GCTGCAGATGCCACA GGTCGGGGAGCTGGG ACCCCTGTGTCCCTT CTGCAGATGCCACAC
GTCGGGGAGCTGGGG CCCCTGTGTCCCTTT TGCAGATGCCACACC TCGGGGAGCTGGGGT
CCCTGTGTCCCTTTT GCAGATGCCACACCT CGGGGAGCTGGGGTA CCTGTGTCCCTTTTG
CAGATGCCACACCTG GGGGAGCTGGGGTAC CTGTGTCCCTTTTGC AGATGCCACACCTGC
GGGAGCTGGGGTACA TGTGTCCCTTTTGCA GATGCCACACCTGCT GGAGCTGGGGTACAG
GTGTCCCTTTTGCAT ATGCCACACCTGCTC GAGCTGGGGTACAGG TGTCCCTTTTGCATA
TGCCACACCTGCTCC AGCTGGGGTACAGGT GTCCCTTTTGCATAA GCCACACCTGCTCCT
GCTGGGGTACAGGTT TCCCTTTTGCATAAG CCACACCTGCTCCTT CTGGGGTACAGGTTT
CCCTTTTGCATAAGA CACACCTGCTCCTTC TGGGGTACAGGTTTG CCTTTTGCATAAGAT
ACACCTGCTCCTTCT GGGGTACAGGTTTGG CTTTTGCATAAGATT TTTTGCATAAGATTA
TTTGCATAAGATTAA TTGCATAAGATTAAA TGCATAAGATTAAAG GCATAAGATTAAAGG
CATAAGATTAAAGGA ATAAGATTAAAGGAA TAAGATTAAAGGAAG AAGATTAAAGGAAGG
AGATTAAAGGAAGGA GATTAAAGGAAGGAA ATTAAAGGAAGGAAA TTAAAGGAAGGAAAA
TAAAGGAAGGAAAAG AAAGGAAGGAAAAGT
EXAMPLE 7
Antisense Oligonucleotides of IGFBP3
[0057] Antisense oligonucleotides to IGFBP3 may be selected from
molecules capable of interacting with one or more of the following
sense oligonucleotides:
5 CTCAGCGCCCAGCCG CCACAGCTTCGCGCC ATCCCTGCGCGCCCA TCAGCGCCCAGCCGC
CACAGCTTCGCGCCG TCCCTGCGCGCCCAG CAGCGCCCAGCCGCT ACAGCTTCGCGCCGT
CCCTGCGCGCCCAGC AGCGCCCAGCCGCTT CAGCTTCGCGCCGTG CCTGCGCGCCCAGCC
GCGCCCAGCCGCTTC AGCTTCGCGCCGTGT CTGCGCGCCCAGCCT CGCCCAGCCGCTTCC
GCTTCGCGCCGTGTA TGCGCGCCCAGCCTG GCCCAGCCGCTTCCT CTTCGCGCCGTGTAC
GCGCGCCCAGCCTGC CCCAGCCGCTTCCTG TTCGCGCCGTGTACT CGCGCCCAGCCTGCC
CCAGCCGCTTCCTGC TCGCGCCGTGTACTG GCGCCCAGCCTGCCA CAGCCGCTTCCTGCC
CGCGCCGTGTACTGT CGCCCAGCCTGCCAA AGCCGCTTCCTGCCT GCGCCGTGTACTGTC
GCCCAGCCTGCCAAG GCCGCTTCCTGCCTG CGCCGTGTACTGTCG CCCAGCCTGCCAAGC
CCGCTTCCTGCCTGG GCCGTGTACTGTCGC CCAGCCTGCCAAGCA CGCTTCCTGCCTGGA
CCGTGTACTGTCGCC CAGCCTGCCAAGCAG GCTTCCTGCCTGGAT CGTGTACTGTCGCCC
AGCCTGCCAAGCAGC CTTCCTGCCTGGATT GTGTACTGTCGCCCC GCCTGCCAAGCAGCG
TTCCTGCCTGGATTC TGTACTGTCGCCCCA CCTGCCAAGCAGCGT TCCTGCCTGGATTCC
GTACTGTCGCCCCAT CTGCCAAGCAGCGTG CCTGCCTGGATTCCA TACTGTCGCCCCATC
TGCCAAGCAGCGTGC CTGCCTGGATTCCAC ACTGTCGCCCCATCC GCCAAGCAGCGTGCC
TGCCTGGATTCCACA CTGTCGCCCCATCCC CCAAGCAGCGTGCCC GCCTGGATTCCACAG
TGTCGCCCCATCCCT CAAGCAGCGTGCCCC CCTGGATTCCACAGC GTCGCCCCATCCCTG
AAGCAGCGTGCCCCG CTGGATTCCACAGCT TCGCCCCATCCCTGC AGCAGCGTGCCCCGG
TGGATTCCACAGCTT CGCCCCATCCCTGCG GCAGCGTGCCCCGGT GGATTCCACAGCTTC
GCCCCATCCCTGCGC CAGCGTGCCCCGGTT GATTCCACAGCTTCG CCCCATCCCTGCGCG
AGCGTGCCCCGGTTG ATTCCACAGCTTCGC CCCATCCCTGCGCGC GCGTGCCCCGGTTGC
TTCCACAGCTTCGCG CCATCCCTGCGCGCC CGTGCCCCGGTTGCA TCCACAGCTTCGCGC
CATCCCTGCGCGCCC GTGCCCCGGTTGCAG TGCCCCGGTTGCAGG TGACTCTGCTGGTGC
GGGGGCTTGGGTCCC GCCCCGGTTGCAGGC GACTCTGCTGGTGCT GGGGCTTGGGTCCCG
CCCCGGTTGCAGGCG ACTCTGCTGGTGCTG GGGCTTGGGTCCCGT CCCGGTTGCAGGCGT
CTCTGCTGGTGCTGC GGCTTGGGTCCCGTG CCGGTTGCAGGCGTC TCTGCTGGTGCTGCT
GCTTGGGTCCCGTGG CGGTTGCAGGCGTCA CTGCTGGTGCTGCTC CTTGGGTCCCGTGGT
GGTTGCAGGCGTCAT TGCTGGTGCTGCTCC TTGGGTCCCGTGGTG GTTGCAGGCGTCATG
GCTGGTGCTGCTCCG TGGGTCCCGTGGTGC TTGCAGGCGTCATGC CTGGTGCTGCTCCGC
GGGTCCCGTGGTGCG TGCAGGCGTCATGCA TGGTGCTGCTCCGCG GGTCCCGTGGTGCGC
GCAGGCGTCATGCAG GGTGCTGCTCCGCGG GTCCCGTGGTGCGCT CAGGCGTCATGCAGC
GTGCTGCTCCGCGGG TCCCGTGGTGCGCTG AGGCGTCATGCAGCG TGCTGCTCCGCGGGC
CCCGTGGTGCGCTGC GGCGTCATGCAGCGG GCTGCTCCGCGGGCC CCGTGGTGCGCTGCG
GCGTCATGCAGCGGG CTGCTCCGCGGGCCG CGTGGTGCGCTGCGA CGTCATGCAGCGGGC
TGCTCCGCGGGCCGC GTGGTGCGCTGCGAG GTCATGCAGCGGGCG GCTCCGCGGGCCGCC
TGGTGCGCTGCGAGC TCATGCAGCGGGCGC CTCCGCGGGCCGCCG GGTGCGCTGCGAGCC
CATGCAGCGGGCGCG TCCGCGGGCCGCCGG GTGCGCTGCGAGCCG ATGCAGCGGGCGCGA
CCGCGGGCCGCCGGT TGCGCTGCGAGCCGT TGCAGCGGGCGCGAC CGCGGGCCGCCGGTG
GCGCTGCGAGCCGTG GCAGCGGGCGCGACC GCGGGCCGCCGGTGG CGCTGCGAGCCGTGC
CAGCGGGCGCGACCC CGGGCCGCCGGTGGC GCTGCGAGCCGTGCG AGCGGGCGCGACCCA
GGGCCGCCGGTGGCG CTGCGAGCCGTGCGA GCGGGCGCGACCCAC GGCCGCCGGTGGCGC
TGCGAGCCGTGCGAC CGGGCGCGACCCACG GCCGCCGGTGGCGCG GCGAGCCGTGCGACG
GGGCGCGACCCACGC CCGCCGGTGGCGCGG CGAGCCGTGCGACGC GGCGCGACCCACGCT
CGCCGGTGGCGCGGG GAGCCGTGCGACGCG GCGCGACCCACGCTC GCCGGTGGCGCGGGC
AGCCGTGCGACGCGC CGCGACCCACGCTCT CCGGTGGCGCGGGCT GCCGTGCGACGCGCG
GCGACCCACGCTCTG CGGTGGCGCGGGCTG CCGTGCGACGCGCGT CGACCCACGCTCTGG
GGTGGCGCGGGCTGG CGTGCGACGCGCGTG GACCCACGCTCTGGG GTGGCGCGGGCTGGC
GTGCGACGCGCGTGC ACCCACGCTCTGGGC TGGCGCGGGCTGGCG TGCGACGCGCGTGCA
CCCACGCTCTGGGCC GGCGCGGGCTGGCGC GCGACGCGCGTGCAC CCACGCTCTGGGCCG
GCGCGGGCTGGCGCG CGACGCGCGTGCACT CACGCTCTGGGCCGC CGCGGGCTGGCGCGA
GACGCGCGTGCACTG ACGCTCTGGGCCGCT GCGGGCTGGCGCGAG ACGCGCGTGCACTGG
CGCTCTGGGCCGCTG CGGGCTGGCGCGAGC CGCGCGTGCACTGGC GCTCTGGGCCGCTGC
GGGCTGGCGCGAGCT GCGCGTGCACTGGCC CTCTGGGCCGCTGCG GGCTGGCGCGAGCTC
CGCGTGCACTGGCCC TCTGGGCCGCTGCGC GCTGGCGCGAGCTCG GCGTGCACTGGCCCA
CTGGGCCGCTGCGCT CTGGCGCGAGCTCGG CGTGCACTGGCCCAG TGGGCCGCTGCGCTG
TGGCGCGAGCTCGGG GTGCACTGGCCCAGT GGGCCGCTGCGCTGA GGCGCGAGCTCGGGG
TGCACTGGCCCAGTG GGCCGCTGCGCTGAC GCGCGAGCTCGGGGG GCACTGGCCCAGTGC
GCCGCTGCGCTGACT CGCGAGCTCGGGGGG CACTGGCCCAGTGCG CCGCTGCGCTGACTC
GCGAGCTCGGGGGGC ACTGGCCCAGTGCGC CGCTGCGCTGACTCT CGAGCTCGGGGGGCT
CTGGCCCAGTGCGCG GCTGCGCTGACTCTG GAGCTCGGGGGGCTT TGGCCCAGTGCGCGC
CTGCGCTGACTCTGC AGCTCGGGGGGCTTG GGCCCAGTGCGCGCC TGCGCTGACTCTGCT
GCTCGGGGGGCTTGG GCCCAGTGCGCGCCT GCGCTGACTCTGCTG CTCGGGGGGCTTGGG
CCCAGTGCGCGCCTC CGCTGACTCTGCTGG TCGGGGGGCTTGGGT CCAGTGCGCGCCTCC
GCTGACTCTGCTGGT CGGGGGGCTTGGGTC CAGTGCGCGCCTCCG CTGACTCTGCTGGTG
GGGGGGCTTGGGTCC AGTGCGCGCCTCCGC GTGCGCGCCTCCGCC GCTGCCTGACGTGCG
TGTGGCTCCGGCCTT TGCGCGCCTCCGCCC CTGCCTGACGTGCGC GTGGCTCCGGCCTTC
GCGCGCCTCCGCCCG TGCCTGACGTGCGCA TGGCTCCGGCCTTCG CGCGCCTCCGCCCGC
GCCTGACGTGCGCAC GGCTCCGGCCTTCGC GCGCCTCCGCCCGCC CCTGACGTGCGCACT
GCTCCGGCCTTCGCT CGCCTCCGCCCGCCG CTGACGTGCGCACTG CTCCGGCCTTCGCTG
GCCTCCGCCCGCCGT TGACGTGCGCACTGA TCCGGCCTTCGCTGC CCTCCGCCCGCCGTG
GACGTGCGCACTGAG CCGGCCTTCGCTGCC CTCCGCCCGCCGTGT ACGTGCGCACTGAGC
CGGCCTTCGCTGCCA TCCGCCCGCCGTGTG CGTGCGCACTGAGCG GGCCTTCGCTGCCAG
CCGCCCGCCGTGTGC GTGCGCACTGAGCGA GCCTTCGCTGCCAGC CGCCCGCCGTGTGCG
TGCGCACTGAGCGAG CCTTCGCTGCCAGCC GCCCGCCGTGTGCGC GCGCACTGAGCGAGG
CTTCGCTGCCAGCCG CCCGCCGTGTGCGCG CGCACTGAGCGAGGG TTCGCTGCCAGCCGT
CCGCCGTGTGCGCGG GCACTGAGCGAGGGC TCGCTGCCAGCCGTC CGCCGTGTGCGCGGA
CACTGAGCGAGGGCC CGCTGCCAGCCGTCG GCCGTGTGCGCGGAG ACTGAGCGAGGGCCA
GCTGCCAGCCGTCGC CCGTGTGCGCGGAGC CTGAGCGAGGGCCAG CTGCCAGCCGTCGCC
CGTGTGCGCGGAGCT TGAGCGAGGGCCAGC TGCCAGCCGTCGCCC GTGTGCGCGGAGCTG
GAGCGAGGGCCAGCC GCCAGCCGTCGCCCG TGTGCGCGGAGCTGG AGCGAGGGCCAGCCG
CCAGCCGTCGCCCGA GTGCGCGGAGCTGGT GCGAGGGCCAGCCGT CAGCCGTCGCCCGAC
TGCGCGGAGCTGGTG CGAGGGCCAGCCGTG AGCCGTCGCCCGACG GCGCGGAGCTGGTGC
GAGGGCCAGCCGTGC GCCGTCGCCCGACGA CGCGGAGCTGGTGCG AGGGCCAGCCGTGCG
CCGTCGCCCGACGAG GCGGAGCTGGTGCGC GGGCCAGCCGTGCGG CGTCGCCCGACGAGG
CGGAGCTGGTGCGCG GGCCAGCCGTGCGGC GTCGCCCGACGAGGC GGAGCTGGTGCGCGA
GCCAGCCGTGCGGCA TCGCCCGACGAGGCG GAGCTGGTGCGCGAG CCAGCCGTGCGGCAT
CGCCCGACGAGGCGC AGCTGGTGCGCGAGC CAGCCGTGCGGCATC GCCCGACGAGGCGCG
GCTGGTGCGCGAGCC AGCCGTGCGGCATCT CCCGACGAGGCGCGA CTGGTGCGCGAGCCG
GCCGTGCGGCATCTA CCGACGAGGCGCGAC TGGTGCGCGAGCCGG CCGTGCGGCATCTAC
CGACGAGGCGCGACC GGTGCGCGAGCCGGG CGTGCGGCATCTACA GACGAGGCGCGACCG
GTGCGCGAGCCGGGC GTGCGGCATCTACAC ACGAGGCGCGACCGC TGCGCGAGCCGGGCT
TGCGGCATCTACACC CGAGGCGCGACCGCT GCGCGAGCCGGGCTG GCGGCATCTACACCG
GAGGCGCGACCGCTG CGCGAGCCGGGCTGC CGGCATCTACACCGA AGGCGCGACCGCTGC
GCGAGCCGGGCTGCG GGCATCTACACCGAG GGCGCGACCGCTGCA CGAGCCGGGCTGCGG
GCATCTACACCGAGC GCGCGACCGCTGCAG GAGCCGGGCTGCGGC CATCTACACCGAGCG
CGCGACCGCTGCAGG AGCCGGGCTGCGGCT ATCTACACCGAGCGC GCGACCGCTGCAGGC
GCCGGGCTGCGGCTG TCTACACCGAGCGCT CGACCGCTGCAGGCG CCGGGCTGCGGCTGC
CTACACCGAGCGCTG GACCGCTGCAGGCGC CGGGCTGCGGCTGCT TACACCGAGCGCTGT
ACCGCTGCAGGCGCT GGGCTGCGGCTGCTG ACACCGAGCGCTGTG CCGCTGCAGGCGCTG
GGCTGCGGCTGCTGC CACCGAGCGCTGTGG CGCTGCAGGCGCTGC GCTGCGGCTGCTGCC
ACCGAGCGCTGTGGC GCTGCAGGCGCTGCT CTGCGGCTGCTGCCT CCGAGCGCTGTGGCT
CTGCAGGCGCTGCTG TGCGGCTGCTGCCTG CGAGCGCTGTGGCTC TGCAGGCGCTGCTGG
GCGGCTGCTGCCTGA GAGCGCTGTGGCTCC GCAGGCGCTGCTGGA CGGCTGCTGCCTGAC
AGCGCTGTGGCTCCG CAGGCGCTGCTGGAC GGCTGCTGCCTGACG GCGCTGTGGCTCCGG
AGGCGCTGCTGGACG GCTGCTGCCTGACGT CGCTGTGGCTCCGGC GGCGCTGCTGGACGG
CTGCTGCCTGACGTG GCTGTGGCTCCGGCC GCGCTGCTGGACGGC TGCTGCCTGACGTGC
CTGTGGCTCCGGCCT CGCTGCTGGACGGCC GCTGCTGGACGGCCG CCTACCTGCTGCCAG
CGCAGCGCCGGCAGT CTGCTGGACGGCCGC CTACCTGCTGCCAGC GCAGCGCCGGCAGTG
TGCTGGACGGCCGCG TACCTGCTGCCAGCG CAGCGCCGGCAGTGT GCTGGACGGCCGCGG
ACCTGCTGCCAGCGC AGCGCCGGCAGTGTG CTGGACGGCCGCGGG CCTGCTGCCAGCGCC
GCGCCGGCAGTGTGG TGGACGGCCGCGGGC CTGCTGCCAGCGCCG CGCCGGCAGTGTGGA
GGACGGCCGCGGGCT TGCTGCCAGCGCCGC GCCGGCAGTGTGGAG GACGGCCGCGGGCTC
GCTGCCAGCGCCGCC CCGGCAGTGTGGAGA ACGGCCGCGGGCTCT CTGCCAGCGCCGCCA
CGGCAGTGTGGAGAG CGGCCGCGGGCTCTG TGCCAGCGCCGCCAG GGCAGTGTGGAGAGC
GGCCGCGGGCTCTGC GCCAGCGCCGCCAGC GCAGTGTGGAGAGCC GCCGCGGGCTCTGCG
CCAGCGCCGCCAGCT CAGTGTGGAGAGCCC CCGCGGGCTCTGCGT CAGCGCCGCCAGCTC
AGTGTGGAGAGCCCG CGCGGGCTCTGCGTC AGCGCCGCCAGCTCC GTGTGGAGAGCCCGT
GCGGGCTCTGCGTCA GCGCCGCCAGCTCCA TGTGGAGAGCCCGTC CGGGCTCTGCGTCAA
CGCCGCCAGCTCCAG GTGGAGAGCCCGTCC GGGCTCTGCGTCAAC GCCGCCAGCTCCAGG
TGGAGAGCCCGTCCG GGCTCTGCGTCAACG CCGCCAGCTCCAGGA GGAGAGCCCGTCCGT
GCTCTGCGTCAACGC CGCCAGCTCCAGGAA GAGAGCCCGTCCGTC CTCTGCGTCAACGCT
GCCAGCTCCAGGAAA AGAGCCCGTCCGTCT TCTGCGTCAACGCTA CCAGCTCCAGGAAAT
GAGCCCGTCCGTCTC CTGCGTCAACGCTAG CAGCTCCAGGAAATG AGCCCGTCCGTCTCC
TGCGTCAACGCTAGT AGCTCCAGGAAATGC GCCCGTCCGTCTCCA GCGTCAACGCTAGTG
GCTCCAGGAAATGCT CCCGTCCGTCTCCAG CGTCAACGCTAGTGC CTCCAGGAAATGCTA
CCGTCCGTCTCCAGC GTCAACGCTAGTGCC TCCAGGAAATGCTAG CGTCCGTCTCCAGCA
TCAACGCTAGTGCCG CCAGGAAATGCTAGT GTCCGTCTCCAGCAC CAACGCTAGTGCCGT
CAGGAAATGCTAGTG TCCGTCTCCAGCACG AACGCTAGTGCCGTC AGGAAATGCTAGTGA
CCGTCTCCAGCACGC ACGCTAGTGCCGTCA GGAAATGCTAGTGAG CGTCTCCAGCACGCA
CGCTAGTGCCGTCAG GAAATGCTAGTGAGT GTCTCCAGCACGCAC GCTAGTGCCGTCAGC
AAATGCTAGTGAGTC TCTCCAGCACGCACC CTAGTGCCGTCAGCC AATGCTAGTGAGTCG
CTCCAGCACGCACCG TAGTGCCGTCAGCCG ATGCTAGTGAGTCGG TCCAGCACGCACCGG
AGTGCCGTCAGCCGC TGCTAGTGAGTCGGA CCAGCACGCACCGGG GTGCCGTCAGCCGCC
GCTAGTGAGTCGGAG CAGCACGCACCGGGT TGCCGTCAGCCGCCT CTAGTGAGTCGGAGG
AGCACGCACCGGGTG GCCGTCAGCCGCCTG TAGTGAGTCGGAGGA GCACGCACCGGGTGT
CCGTCAGCCGCCTGC AGTGAGTCGGAGGAA CACGCACCGGGTGTC CGTCAGCCGCCTGCG
GTGAGTCGGAGGAAG ACGCACCGGGTGTCT GTCAGCCGCCTGCGC TGAGTCGGAGGAAGA
CGCACCGGGTGTCTG TCAGCCGCCTGCGCG GAGTCGGAGGAAGAC GCACCGGGTGTCTGA
CAGCCGCCTGCGCGC AGTCGGAGGAAGACC CACCGGGTGTCTGAT AGCCGCCTGCGCGCC
GTCGGAGGAAGACCG ACCGGGTGTCTGATC GCCGCCTGCGCGCCT TCGGAGGAAGACCGC
CCGGGTGTCTGATCC CCGCCTGCGCGCCTA CGGAGGAAGACCGCA CGGGTGTCTGATCCC
CGCCTGCGCGCCTAC GGAGGAAGACCGCAG GGGTGTCTGATCCCA GCCTGCGCGCCTACC
GAGGAAGACCGCAGC GGTGTCTGATCCCAA CCTGCGCGCCTACCT AGGAAGACCGCAGCG
GTGTCTGATCCCAAG CTGCGCGCCTACCTG GGAAGACCGCAGCGC TGTCTGATCCCAAGT
TGCGCGCCTACCTGC GAAGACCGCAGCGCC GTCTGATCCCAAGTT GCGCGCCTACCTGCT
AAGACCGCAGCGCCG TCTGATCCCAAGTTC CGCGCCTACCTGCTG AGACCGCAGCGCCGG
CTGATCCCAAGTTCC GCGCCTACCTGCTGC GACCGCAGCGCCGGC TGATCCCAAGTTCCA
CGCCTACCTGCTGCC ACCGCAGCGCCGGCA GATCCCAAGTTCCAC GCCTACCTGCTGCCA
CCGCAGCGCCGGCAG ATCCCAAGTTCCACC TCCCAAGTTCCACCC AAGACAGCCAGCGCT
TTCTCCTCCGAGTCC CCCAAGTTCCACCCC AGACAGCCAGCGCTA TCTCCTCCGAGTCCA
CCAAGTTCCACCCCC GACAGCCAGCGCTAC CTCCTCCGAGTCCAA CAAGTTCCACCCCCT
ACAGCCAGCGCTACA TCCTCCGAGTCCAAG AAGTTCCACCCCCTC CAGCCAGCGCTACAA
CCTCCGAGTCCAAGC AGTTCCACCCCCTCC AGCCAGCGCTACAAA CTCCGAGTCCAAGCG
GTTCCACCCCCTCCA GCCAGCGCTACAAAG TCCGAGTCCAAGCGG TTCCACCCCCTCCAT
CCAGCGCTACAAAGT CCGAGTCCAAGCGGG TCCACCCCCTCCATT CAGCGCTACAAAGTT
CGAGTCCAAGCGGGA CCACCCCCTCCATTC AGCGCTACAAAGTTG GAGTCCAAGCGGGAG
CACCCCCTCCATTCA GCGCTACAAAGTTGA AGTCCAAGCGGGAGA ACCCCCTCCATTCAA
CGCTACAAAGTTGAC GTCCAAGCGGGAGAC CCCCCTCCATTCAAA GCTACAAAGTTGACT
TCCAAGCGGGAGACA CCCCTCCATTCAAAG CTACAAAGTTGACTA CCAAGCGGGAGACAG
CCCTCCATTCAAAGA TACAAAGTTGACTAC CAAGCGGGAGACAGA CCTCCATTCAAAGAT
ACAAAGTTGACTACG AAGCGGGAGACAGAA CTCCATTCAAAGATA CAAAGTTGACTACGA
AGCGGGAGACAGAAT TCCATTCAAAGATAA AAAGTTGACTACGAG GCGGGAGACAGAATA
CCATTCAAAGATAAT AAGTTGACTACGAGT CGGGAGACAGAATAT CATTCAAAGATAATC
AGTTGACTACGAGTC GGGAGACAGAATATG ATTCAAAGATAATCA GTTGACTACGAGTCT
GGAGACAGAATATGG TTCAAAGATAATCAT TTGACTACGAGTCTC GAGACAGAATATGGT
TCAAAGATAATCATC TGACTACGAGTCTCA AGACAGAATATGGTC CAAAGATAATCATCA
GACTACGAGTCTCAG GACAGAATATGGTCC AAAGATAATCATCAT ACTACGAGTCTCAGA
ACAGAATATGGTCCC AAGATAATCATCATC CTACGAGTCTCAGAG CAGAATATGGTCCCT
AGATAATCATCATCA TACGAGTCTCAGAGC AGAATATGGTCCCTG GATAATCATCATCAA
ACGAGTCTCAGAGCA GAATATGGTCCCTGC ATAATCATCATCAAG CGAGTCTCAGAGCAC
AATATGGTCCCTGCC TAATCATCATCAAGA GAGTCTCAGAGCACA ATATGGTCCCTGCCG
AATCATCATCAAGAA AGTCTCAGAGCACAG TATGGTCCCTGCCGT ATCATCATCAAGAAA
GTCTCAGAGCACAGA ATGGTCCCTGCCGTA TCATCATCAAGAAAG TCTCAGAGCACAGAT
TGGTCCCTGCCGTAG CATCATCAAGAAAGG CTCAGAGCACAGATA GGTCCCTGCCGTAGA
ATCATCAAGAAAGGG TCAGAGCACAGATAC GTCCCTGCCGTAGAG TCATCAAGAAAGGGC
CAGAGCACAGATACC TCCCTGCCGTAGAGA CATCAAGAAAGGGCA AGAGCACAGATACCC
CCCTGCCGTAGAGAA ATCAAGAAAGGGCAT GAGCACAGATACCCA CCTGCCGTAGAGAAA
TCAAGAAAGGGCATG AGCACAGATACCCAG CTGCCGTAGAGAAAT CAAGAAAGGGCATGC
GCACAGATACCCAGA TGCCGTAGAGAAATG AAGAAAGGGCATGCT CACAGATACCCAGAA
GCCGTAGAGAAATGG AGAAAGGGCATGCTA ACAGATACCCAGAAC CCGTAGAGAAATGGA
GAAAGGGCATGCTAA CAGATACCCAGAACT CGTAGAGAAATGGAA AAAGGGCATGCTAAA
AGATACCCAGAACTT GTAGAGAAATGGAAG AAGGGCATGCTAAAG GATACCCAGAACTTC
TAGAGAAATGGAAGA AGGGCATGCTAAAGA ATACCCAGAACTTCT AGAGAAATGGAAGAC
GGGCATGCTAAAGAC TACCCAGAACTTCTC GAGAAATGGAAGACA GGCATGCTAAAGACA
ACCCAGAACTTCTCC AGAAATGGAAGACAC GCATGCTAAAGACAG CCCAGAACTTCTCCT
GAAATGGAAGACACA CATGCTAAAGACAGC CCAGAACTTCTCCTC AAATGGAAGACACAC
ATGCTAAAGACAGCC CAGAACTTCTCCTCC AATGGAAGACACACT TGCTAAAGACAGCCA
AGAACTTCTCCTCCG ATGGAAGACACACTG GCTAAAGACAGCCAG GAACTTCTCCTCCGA
TGGAAGACACACTGA
CTAAAGACAGCCAGC AACTTCTCCTCCGAG GGAAGACACACTGAA TAAAGACAGCCAGCG
ACTTCTCCTCCGAGT GAAGACACACTGAAT AAAGACAGCCAGCGC CTTCTCCTCCGAGTC
AAGACACACTGAATC AGACACACTGAATCA TTCCCAACTGTGACA GGCAGGAAGCGGGGC
GACACACTGAATCAC TCCCAACTGTGACAA GCAGGAAGCGGGGCT ACACACTGAATCACC
CCCAACTGTGACAAG CAGGAAGCGGGGCTT CACACTGAATCACCT CCAACTGTGACAAGA
AGGAAGCGGGGCTTC ACACTGAATCACCTG CAACTGTGACAAGAA GGAAGCGGGGCTTCT
CACTGAATCACCTGA AACTGTGACAAGAAG GAAGCGGGGCTTCTG ACTGAATCACCTGAA
ACTGTGACAAGAAGG AAGCGGGGCTTCTGC CTGAATCACCTGAAG CTGTGACAAGAAGGG
AGCGGGGCTTCTGCT TGAATCACCTGAAGT TGTGACAAGAAGGGA GCGGGGCTTCTGCTG
GAATCACCTGAAGTT GTGACAAGAAGGGAT CGGGGCTTCTGCTGG AATCACCTGAAGTTC
TGACAAGAAGGGATT GGGGCTTCTGCTGGT ATCACCTGAAGTTCC GACAAGAAGGGATTT
GGGCTTCTGCTGGTG TCACCTGAAGTTCCT ACAAGAAGGGATTTT GGCTTCTGCTGGTGT
CACCTGAAGTTCCTC CAAGAAGGGATTTTA GCTTCTGCTGGTGTG ACCTGAAGTTCCTCA
AAGAAGGGATTTTAT CTTCTGCTGGTGTGT CCTGAAGTTCCTCAA AGAAGGGATTTTATA
TTCTGCTGGTGTGTG CTGAAGTTCCTCAAT GAAGGGATTTTATAA TCTGCTGGTGTGTGG
TGAAGTTCCTCAATG AAGGGATTTTATAAG CTGCTGGTGTGTGGA GAAGTTCCTCAATGT
AGGGATTTTATAAGA TGCTGGTGTGTGGAT AAGTTCCTCAATGTG GGGATTTTATAAGAA
GCTGGTGTGTGGATA AGTTCCTCAATGTGC GGATTTTATAAGAAA CTGGTGTGTGGATAA
GTTCCTCAATGTGCT GATTTTATAAGAAAA TGGTGTGTGGATAAG TTCCTCAATGTGCTG
ATTTTATAAGAAAAA GGTGTGTGGATAAGT TCCTCAATGTGCTGA TTTTATAAGAAAAAG
GTGTGTGGATAAGTA CCTCAATGTGCTGAG TTTATAAGAAAAAGC TGTGTGGATAAGTAT
CTCAATGTGCTGAGT TTATAAGAAAAAGCA GTGTGGATAAGTATG TCAATGTGCTGAGTC
TATAAGAAAAAGCAG TGTGGATAAGTATGG CAATGTGCTGAGTCC ATAAGAAAAAGCAGT
GTGGATAAGTATGGG AATGTGCTGAGTCCC TAAGAAAAAGCAGTG TGGATAAGTATGGGC
ATGTGCTGAGTCCCA AAGAAAAAGCAGTGT GGATAAGTATGGGCA TGTGCTGAGTCCCAG
AGAAAAAGCAGTGTC GATAAGTATGGGCAG GTGCTGAGTCCCAGG GAAAAAGCAGTGTCG
ATAAGTATGGGCAGC TGCTGAGTCCCAGGG AAAAAGCAGTGTCGC TAAGTATGGGCAGCC
GCTGAGTCCCAGGGG AAAAGCAGTGTCGCC AAGTATGGGCAGCCT CTGAGTCCCAGGGGT
AAAGCAGTGTCGCCC AGTATGGGCAGCCTC TGAGTCCCAGGGGTG AAGCAGTGTCGCCCT
GTATGGGCAGCCTCT GAGTCCCAGGGGTGT AGCAGTGTCGCCCTT TATGGGCAGCCTCTC
AGTCCCAGGGGTGTA GCAGTGTCGCCCTTC ATGGGCAGCCTCTCC GTCCCAGGGGTGTAC
CAGTGTCGCCCTTCC TGGGCAGCCTCTCCC TCCCAGGGGTGTACA AGTGTCGCCCTTCCA
GGGCAGCCTCTCCCA CCCAGGGGTGTACAC GTGTCGCCCTTCCAA GGCAGCCTCTCCCAG
CCAGGGGTGTACACA TGTCGCCCTTCCAAA GCAGCCTCTCCCAGG CAGGGGTGTACACAT
GTCGCCCTTCCAAAG CAGCCTCTCCCAGGC AGGGGTGTACACATT TCGCCCTTCCAAAGG
AGCCTCTCCCAGGCT GGGGTGTACACATTC CGCCCTTCCAAAGGC GCCTCTCCCAGGCTA
GGGTGTACACATTCC GCCCTTCCAAAGGCA CCTCTCCCAGGCTAC GGTGTACACATTCCC
CCCTTCCAAAGGCAG CTCTCCCAGGCTACA GTGTACACATTCCCA CCTTCCAAAGGCAGG
TCTCCCAGGCTACAC TGTACACATTCCCAA CTTCCAAAGGCAGGA CTCCCAGGCTACACC
GTACACATTCCCAAC TTCCAAAGGCAGGAA TCCCAGGCTACACCA TACACATTCCCAACT
TCCAAAGGCAGGAAG CCCAGGCTACACCAC ACACATTCCCAACTG CCAAAGGCAGGAAGC
CCAGGCTACACCACC CACATTCCCAACTGT CAAAGGCAGGAAGCG CAGGCTACACCACCA
ACATTCCCAACTGTG AAAGGCAGGAAGCGG AGGCTACACCACCAA CATTCCCAACTGTGA
AAGGCAGGAAGCGGG GGCTACACCACCAAG ATTCCCAACTGTGAC AGGCAGGAAGCGGGG
GCTACACCACCAAGG CTACACCACCAAGGG CGCCTGCCGCAAGTT CCAAGGACATGACCA
TACACCACCAAGGGG GCCTGCCGCAAGTTA CAAGGACATGACCAG ACACCACCAAGGGGA
CCTGCCGCAAGTTAA AAGGACATGACCAGC CACCACCAAGGGGAA CTGCCGCAAGTTAAT
AGGACATGACCAGCA ACCACCAAGGGGAAG TGCCGCAAGTTAATG GGACATGACCAGCAG
CCACCAAGGGGAAGG GCCGCAAGTTAATGT GACATGACCAGCAGC CACCAAGGGGAAGGA
CCGCAAGTTAATGTG ACATGACCAGCAGCT ACCAAGGGGAAGGAG CGCAAGTTAATGTGG
CATGACCAGCAGCTG CCAAGGGGAAGGAGG GCAAGTTAATGTGGA ATGACCAGCAGCTGG
CAAGGGGAAGGAGGA CAAGTTAATGTGGAG TGACCAGCAGCTGGC AAGGGGAAGGAGGAC
AAGTTAATGTGGAGC GACCAGCAGCTGGCT AGGGGAAGGAGGACG AGTTAATGTGGAGCT
ACCAGCAGCTGGCTA GGGGAAGGAGGACGT GTTAATGTGGAGCTC CCAGCAGCTGGCTAC
GGGAAGGAGGACGTG TTAATGTGGAGCTCA CAGCAGCTGGCTACA GGAAGGAGGACGTGC
TAATGTGGAGCTCAA AGCAGCTGGCTACAG GAAGGAGGACGTGCA AATGTGGAGCTCAAA
GCAGCTGGCTACAGC AAGGAGGACGTGCAC ATGTGGAGCTCAAAT CAGCTGGCTACAGCC
AGGAGGACGTGCACT TGTGGAGCTCAAATA AGCTGGCTACAGCCT GGAGGACGTGCACTG
GTGGAGCTCAAATAT GCTGGCTACAGCCTC GAGGACGTGCACTGC TGGAGCTCAAATATG
CTGGCTACAGCCTCG AGGACGTGCACTGCT GGAGCTCAAATATGC TGGCTACAGCCTCGA
GGACGTGCACTGCTA GAGCTCAAATATGCC GGCTACAGCCTCGAT GACGTGCACTGCTAC
AGCTCAAATATGCCT GCTACAGCCTCGATT ACGTGCACTGCTACA GCTCAAATATGCCTT
CTACAGCCTCGATTT CGTGCACTGCTACAG CTCAAATATGCCTTA TACAGCCTCGATTTA
GTGCACTGCTACAGC TCAAATATGCCTTAT ACAGCCTCGATTTAT TGCACTGCTACAGCA
CAAATATGCCTTATT CAGCCTCGATTTATA GCACTGCTACAGCAT AAATATGCCTTATTT
AGCCTCGATTTATAT CACTGCTACAGCATG AATATGCCTTATTTT GCCTCGATTTATATT
ACTGCTACAGCATGC ATATGCCTTATTTTG CCTCGATTTATATTT CTGCTACAGCATGCA
TATGCCTTATTTTGC CTCGATTTATATTTC TGCTACAGCATGCAG ATGCCTTATTTTGCA
TCGATTTATATTTCT GCTACAGCATGCAGA TGCCTTATTTTGCAC CGATTTATATTTCTG
CTACAGCATGCAGAG GCCTTATTTTGCACA GATTTATATTTCTGT TACAGCATGCAGAGC
CCTTATTTTGCACAA ATTTATATTTCTGTT ACAGCATGCAGAGCA CTTATTTTGCACAAA
TTTATATTTCTGTTT CAGCATGCAGAGCAA TTATTTTGCACAAAA TTATATTTCTGTTTG
AGCATGCAGAGCAAG TATTTTGCACAAAAG TATATTTCTGTTTGT GCATGCAGAGCAAGT
ATTTTGCACAAAAGA ATATTTCTGTTTGTG CATGCAGAGCAAGTA TTTTGCACAAAAGAC
TATTTCTGTTTGTGG ATGCAGAGCAAGTAG TTTGCACAAAAGACT ATTTCTGTTTGTGGT
TGCAGAGCAAGTAGA TTGCACAAAAGACTG TTTCTGTTTGTGGTG GCAGAGCAAGTAGAC
TGCACAAAAGACTGC TTCTGTTTGTGGTGA CAGAGCAAGTAGACG GCACAAAAGACTGCC
TCTGTTTGTGGTGAA AGAGCAAGTAGACGC CACAAAAGACTGCCA CTGTTTGTGGTGAAC
GAGCAAGTAGACGCC ACAAAAGACTGCCAA TGTTTGTGGTGAACT AGCAAGTAGACGCCT
CAAAAGACTGCCAAG GTTTGTGGTGAACTG GCAAGTAGACGCCTG AAAAGACTGCCAAGG
TTTGTGGTGAACTGA CAAGTAGACGCCTGC AAAGACTGCCAAGGA TTGTGGTGAACTGAT
AAGTAGACGCCTGCC AAGACTGCCAAGGAC TGTGGTGAACTGATT AGTAGACGCCTGCCG
AGACTGCCAAGGACA GTGGTGAACTGATTT GTAGACGCCTGCCGC GACTGCCAAGGACAT
TGGTGAACTGATTTT TAGACGCCTGCCGCA ACTGCCAAGGACATG GGTGAACTGATTTTT
AGACGCCTGCCGCAA CTGCCAAGGACATGA GTGAACTGATTTTTT GACGCCTGCCGCAAG
TGCCAAGGACATGAC TGAACTGATTTTTTT ACGCCTGCCGCAAGT GCCAAGGACATGACC
GAACTGATTTTTTTT AACTGATTTTTTTTA CTTTGAATGGTAAAC TTGAATTTTCTTGTC
ACTGATTTTTTTTAA TTTGAATGGTAAACT TGAATTTTCTTGTCG CTGATTTTTTTTAAA
TTGAATGGTAAACTT GAATTTTCTTGTCGC TGATTTTTTTTAAAC TGAATGGTAAACTTG
AATTTTCTTGTCGCT GATTTTTTTTAAACC GAATGGTAAACTTGA ATTTTCTTGTCGCTT
ATTTTTTTTAAACCA AATGGTAAACTTGAG TTTTCTTGTCGCTTC TTTTTTTTAAACCAA
ATGGTAAACTTGAGC TTTCTTGTCGCTTCC TTTTTTTAAACCAAA TGGTAAACTTGAGCA
TTCTTGTCGCTTCCT TTTTTTAAACCAAAG GGTAAACTTGAGCAT TCTTGTCGCTTCCTA
TTTTTAAACCAAAGT GTAAACTTGAGCATC CTTGTCGCTTCCTAT TTTTAAACCAAAGTT
TAAACTTGAGCATCT TTGTCGCTTCCTATC TTTAAACCAAAGTTT AAACTTGAGCATCTT
TGTCGCTTCCTATCA TTAAACCAAAGTTTA AACTTGAGCATCTTT GTCGCTTCCTATCAA
TAAACCAAAGTTTAG ACTTGAGCATCTTTT TCGCTTCCTATCAAA AAACCAAAGTTTAGA
CTTGAGCATCTTTTC CGCTTCCTATCAAAA AACCAAAGTTTAGAA TTGAGCATCTTTTCA
GCTTCCTATCAAAAT ACCAAAGTTTAGAAA TGAGCATCTTTTCAC CTTCCTATCAAAATA
CCAAAGTTTAGAAAG GAGCATCTTTTCACT TTCCTATCAAAATAT CAAAGTTTAGAAAGA
AGCATCTTTTCACTT TCCTATCAAAATATT AAAGTTTAGAAAGAG GCATCTTTTCACTTT
CCTATCAAAATATTC AAGTTTAGAAAGAGG CATCTTTTCACTTTC CTATCAAAATATTCA
AGTTTAGAAAGAGGT ATCTTTTCACTTTCC TATCAAAATATTCAG GTTTAGAAAGAGGTT
TCTTTTCACTTTCCA ATCAAAATATTCAGA TTTAGAAAGAGGTTT CTTTTCACTTTCCAG
TCAAAATATTCAGAG TTAGAAAGAGGTTTT TTTTCACTTTCCAGT CAAAATATTCAGAGA
TAGAAAGAGGTTTTT TTTCACTTTCCAGTA AAAATATTCAGAGAC AGAAAGAGGTTTTTG
TTCACTTTCCAGTAG AAATATTCAGAGACT GAAAGAGGTTTTTGA TCACTTTCCAGTAGT
AATATTCAGAGACTC AAAGAGGTTTTTGAA CACTTTCCAGTAGTC ATATTCAGAGACTCG
AAGAGGTTTTTGAAA ACTTTCCAGTAGTCA TATTCAGAGACTCGA AGAGGTTTTTGAAAT
CTTTCCAGTAGTCAG ATTCAGAGACTCGAG GAGGTTTTTGAAATG TTTCCAGTAGTCAGC
TTCAGAGACTCGAGC AGGTTTTTGAAATGC TTCCAGTAGTCAGCA TCAGAGACTCGAGCA
GGTTTTTGAAATGCC TCCAGTAGTCAGCAA CAGAGACTCGAGCAC GTTTTTGAAATGCCT
CCAGTAGTCAGCAAA AGAGACTCGAGCACA TTTTTGAAATGCCTA CAGTAGTCAGCAAAG
GAGACTCGAGCACAG TTTTGAAATGCCTAT AGTAGTCAGCAAAGA AGACTCGAGCACAGC
TTTGAAATGCCTATG GTAGTCAGCAAAGAG GACTCGAGCACAGCA TTGAAATGCCTATGG
TAGTCAGCAAAGAGC ACTCGAGCACAGCAC TGAAATGCCTATGGT AGTCAGCAAAGAGCA
CTCGAGCACAGCACC GAAATGCCTATGGTT GTCAGCAAAGAGCAG TCGAGCACAGCACCC
AAATGCCTATGGTTT TCAGCAAAGAGCAGT CGAGCACAGCACCCA AATGCCTATGGTTTC
CAGCAAAGAGCAGTT GAGCACAGCACCCAG ATGCCTATGGTTTCT AGCAAAGAGCAGTTT
AGCACAGCACCCAGA TGCCTATGGTTTCTT GCAAAGAGCAGTTTG GCACAGCACCCAGAC
GCCTATGGTTTCTTT CAAAGAGCAGTTTGA CACAGCACCCAGACT CCTATGGTTTCTTTG
AAAGAGCAGTTTGAA ACAGCACCCAGACTT CTATGGTTTCTTTGA AAGAGCAGTTTGAAT
CAGCACCCAGACTTC TATGGTTTCTTTGAA AGAGCAGTTTGAATT AGCACCCAGACTTCA
ATGGTTTCTTTGAAT GAGCAGTTTGAATTT GCACCCAGACTTCAT TGGTTTCTTTGAATG
AGCAGTTTGAATTTT CACCCAGACTTCATG GGTTTCTTTGAATGG GCAGTTTGAATTTTC
ACCCAGACTTCATGC GTTTCTTTGAATGGT CAGTTTGAATTTTCT CCCAGACTTCATGCG
TTTCTTTGAATGGTA AGTTTGAATTTTCTT CCAGACTTCATGCGC TTCTTTGAATGGTAA
GTTTGAATTTTCTTG CAGACTTCATGCGCC TCTTTGAATGGTAAA TTTGAATTTTCTTGT
AGACTTCATGCGCCC GACTTCATGCGCCCG ACTTTGTGACTTAGG CCCCGTACAGTGCGC
ACTTCATGCGCCCGT CTTTGTGACTTAGGC CCCGTACAGTGCGCA CTTCATGCGCCCGTG
TTTGTGACTTAGGCG CCGTACAGTGCGCAC TTCATGCGCCCGTGG TTGTGACTTAGGCGG
CGTACAGTGCGCACA TCATGCGCCCGTGGA TGTGACTTAGGCGGC GTACAGTGCGCACAG
CATGCGCCCGTGGAA GTGACTTAGGCGGCT TACAGTGCGCACAGG ATGCGCCCGTGGAAT
TGACTTAGGCGGCTG ACAGTGCGCACAGGC TGCGCCCGTGGAATG GACTTAGGCGGCTGT
CAGTGCGCACAGGCT GCGCCCGTGGAATGC ACTTAGGCGGCTGTG AGTGCGCACAGGCTT
CGCCCGTGGAATGCT CTTAGGCGGCTGTGT GTGCGCACAGGCTTT GCCCGTGGAATGCTC
TTAGGCGGCTGTGTT TGCGCACAGGCTTTA CCCGTGGAATGCTCA TAGGCGGCTGTGTTG
GCGCACAGGCTTTAT CCGTGGAATGCTCAC AGGCGGCTGTGTTGC CGCACAGGCTTTATC
CGTGGAATGCTCACC GGCGGCTGTGTTGCC GCACAGGCTTTATCG GTGGAATGCTCACCA
GCGGCTGTGTTGCCT CACAGGCTTTATCGA TGGAATGCTCACCAC CGGCTGTGTTGCCTA
ACAGGCTTTATCGAG GGAATGCTCACCACA GGCTGTGTTGCCTAT CAGGCTTTATCGAGA
GAATGCTCACCACAT GCTGTGTTGCCTATG AGGCTTTATCGAGAA AATGCTCACCACATG
CTGTGTTGCCTATGT GGCTTTATCGAGAAT ATGCTCACCACATGT TGTGTTGCCTATGTA
GCTTTATCGAGAATA TGCTCACCACATGTT GTGTTGCCTATGTAG CTTTATCGAGAATAG
GCTCACCACATGTTG TGTTGCCTATGTAGA TTTATCGAGAATAGG CTCACCACATGTTGG
GTTGCCTATGTAGAG TTATCGAGAATAGGA TCACCACATGTTGGT TTGCCTATGTAGAGA
TATCGAGAATAGGAA CACCACATGTTGGTC TGCCTATGTAGAGAA ATCGAGAATAGGAAA
ACCACATGTTGGTCG GCCTATGTAGAGAAC TCGAGAATAGGAAAA CCACATGTTGGTCGA
CCTATGTAGAGAACA CGAGAATAGGAAAAC CACATGTTGGTCGAA CTATGTAGAGAACAC
GAGAATAGGAAAACC ACATGTTGGTCGAAG TATGTAGAGAACACG AGAATAGGAAAACCT
CATGTTGGTCGAAGC ATGTAGAGAACACGC GAATAGGAAAACCTT ATGTTGGTCGAAGCG
TGTAGAGAACACGCT AATAGGAAAACCTTT TGTTGGTCGAAGCGG GTAGAGAACACGCTT
ATAGGAAAACCTTTA GTTGGTCGAAGCGGC TAGAGAACACGCTTC TAGGAAAACCTTTAA
TTGGTCGAAGCGGCC AGAGAACACGCTTCA AGGAAAACCTTTAAA TGGTCGAAGCGGCCG
GAGAACACGCTTCAC GGAAAACCTTTAAAC GGTCGAAGCGGCCGA AGAACACGCTTCACC
GAAAACCTTTAAACC GTCGAAGCGGCCGAC GAACACGCTTCACCC AAAACCTTTAAACCC
TCGAAGCGGCCGACC AACACGCTTCACCCC AAACCTTTAAACCCC CGAAGCGGCCGACCA
ACACGCTTCACCCCC AACCTTTAAACCCCG GAAGCGGCCGACCAC CACGCTTCACCCCCA
ACCTTTAAACCCCGG AAGCGGCCGACCACT ACGCTTCACCCCCAC CCTTTAAACCCCGGT
AGCGGCCGACCACTG CGCTTCACCCCCACT CTTTAAACCCCGGTC GCGGCCGACCACTGA
GCTTCACCCCCACTC TTTAAACCCCGGTCA CGGCCGACCACTGAC CTTCACCCCCACTCC
TTAAACCCCGGTCAT GGCCGACCACTGACT TTCACCCCCACTCCC TAAACCCCGGTCATC
GCCGACCACTGACTT TCACCCCCACTCCCC AAACCCCGGTCATCC CCGACCACTGACTTT
CACCCCCACTCCCCG AACCCCGGTCATCCG CGACCACTGACTTTG ACCCCCACTCCCCGT
ACCCCGGTCATCCGG GACCACTGACTTTGT CCCCCACTCCCCGTA CCCCGGTCATCCGGA
ACCACTGACTTTGTG CCCCACTCCCCGTAC CCCGGTCATCCGGAC CCACTGACTTTGTGA
CCCACTCCCCGTACA CCGGTCATCCGGACA CACTGACTTTGTGAC CCACTCCCCGTACAG
CGGTCATCCGGACAT ACTGACTTTGTGACT CACTCCCCGTACAGT GGTCATCCGGACATC
CTGACTTTGTGACTT ACTCCCCGTACAGTG GTCATCCGGACATCC TGACTTTGTGACTTA
CTCCCCGTACAGTGC TCATCCGGACATCCC GACTTTGTGACTTAG TCCCCGTACAGTGCG
CATCCGGACATCCCA ATCCGGACATCCCAA TGAAACAAGGGCGTG TGTACTGCTTGGGGA
TCCGGACATCCCAAC GAAACAAGGGCGTGG GTACTGCTTGGGGAC CCGGACATCCCAACG
AAACAAGGGCGTGGA TACTGCTTGGGGACT CGGACATCCCAACGC AACAAGGGCGTGGAT
ACTGCTTGGGGACTA GGACATCCCAACGCA ACAAGGGCGTGGATC CTGCTTGGGGACTAT
GACATCCCAACGCAT CAAGGGCGTGGATCC TGCTTGGGGACTATT ACATCCCAACGCATG
AAGGGCGTGGATCCC GCTTGGGGACTATTG CATCCCAACGCATGC AGGGCGTGGATCCCT
CTTGGGGACTATTGG ATCCCAACGCATGCT GGGCGTGGATCCCTC TTGGGGACTATTGGA
TCCCAACGCATGCTC GGCGTGGATCCCTCA TGGGGACTATTGGAG CCCAACGCATGCTCC
GCGTGGATCCCTCAA GGGGACTATTGGAGA CCAACGCATGCTCCT CGTGGATCCCTCAAC
GGGACTATTGGAGAA CAACGCATGCTCCTG GTGGATCCCTCAACC GGACTATTGGAGAAA
AACGCATGCTCCTGG TGGATCCCTCAACCA GACTATTGGAGAAAA ACGCATGCTCCTGGA
GGATCCCTCAACCAA ACTATTGGAGAAAAT CGCATGCTCCTGGAG GATCCCTCAACCAAG
CTATTGGAGAAAATA GCATGCTCCTGGAGC ATCCCTCAACCAAGA TATTGGAGAAAATAA
CATGCTCCTGGAGCT TCCCTCAACCAAGAA ATTGGAGAAAATAAG ATGCTCCTGGAGCTC
CCCTCAACCAAGAAG TTGGAGAAAATAAGG TGCTCCTGGAGCTCA CCTCAACCAAGAAGA
TGGAGAAAATAAGGT GCTCCTGGAGCTCAC CTCAACCAAGAAGAA GGAGAAAATAAGGTG
CTCCTGGAGCTCACA TCAACCAAGAAGAAT GAGAAAATAAGGTGG TCCTGGAGCTCACAG
CAACCAAGAAGAATG AGAAAATAAGGTGGA CCTGGAGCTCACAGC AACCAAGAAGAATGT
GAAAATAAGGTGGAG
CTGGAGCTCACAGCC ACCAAGAAGAATGTT AAAATAAGGTGGAGT TGGAGCTCACAGCCT
CCAAGAAGAATGTTT AAATAAGGTGGAGTC GGAGCTCACAGCCTT CAAGAAGAATGTTTA
AATAAGGTGGAGTCC GAGCTCACAGCCTTC AAGAAGAATGTTTAT ATAAGGTGGAGTCCT
AGCTCACAGCCTTCT AGAAGAATGTTTATG TAAGGTGGAGTCCTA GCTCACAGCCTTCTG
GAAGAATGTTTATGT AAGGTGGAGTCCTAC CTCACAGCCTTCTGT AAGAATGTTTATGTC
AGGTGGAGTCCTACT TCACAGCCTTCTGTG AGAATGTTTATGTCT GGTGGAGTCCTACTT
CACAGCCTTCTGTGG GAATGTTTATGTCTT GTGGAGTCCTACTTG ACAGCCTTCTGTGGT
AATGTTTATGTCTTC TGGAGTCCTACTTGT CAGCCTTCTGTGGTG ATGTTTATGTCTTCA
GGAGTCCTACTTGTT AGCCTTCTGTGGTGT TGTTTATGTCTTCAA GAGTCCTACTTGTTT
GCCTTCTGTGGTGTC GTTTATGTCTTCAAG AGTCCTACTTGTTTA CCTTCTGTGGTGTCA
TTTATGTCTTCAAGT GTCCTACTTGTTTAA CTTCTGTGGTGTCAT TTATGTCTTCAAGTG
TCCTACTTGTTTAAA TTCTGTGGTGTCATT TATGTCTTCAAGTGA CCTACTTGTTTAAAA
TCTGTGGTGTCATTT ATGTCTTCAAGTGAC CTACTTGTTTAAAAA CTGTGGTGTCATTTC
TGTCTTCAAGTGACC TACTTGTTTAAAAAA TGTGGTGTCATTTCT GTCTTCAAGTGACCT
ACTTGTTTAAAAAAT GTGGTGTCATTTCTG TCTTCAAGTGACCTG CTTGTTTAAAAAATA
TGGTGTCATTTCTGA CTTCAAGTGACCTGT TTGTTTAAAAAATAT GGTGTCATTTCTGAA
TTCAAGTGACCTGTA TGTTTAAAAAATATG GTGTCATTTCTGAAA TCAAGTGACCTGTAC
GTTTAAAAAATATGT TGTCATTTCTGAAAC CAAGTGACCTGTACT TTTAAAAAATATGTA
GTCATTTCTGAAACA AAGTGACCTGTACTG TTAAAAAATATGTAT TCATTTCTGAAACAA
AGTGACCTGTACTGC TAAAAAATATGTATC CATTTCTGAAACAAG GTGACCTGTACTGCT
AAAAAATATGTATCT ATTTCTGAAACAAGG TGACCTGTACTGCTT AAAAATATGTATCTA
TTTCTGAAACAAGGG GACCTGTACTGCTTG AAAATATGTATCTAA TTCTGAAACAAGGGC
ACCTGTACTGCTTGG AAATATGTATCTAAG TCTGAAACAAGGGCG CCTGTACTGCTTGGG
AATATGTATCTAAGA CTGAAACAAGGGCGT CTGTACTGCTTGGGG ATATGTATCTAAGAA
TATGTATCTAAGAAT GGCCCTCCTCTTCAG GCTTTTGCTGCGGCC ATGTATCTAAGAATG
GCCCTCCTCTTCAGG CTTTTGCTGCGGCCC TGTATCTAAGAATGT CCCTCCTCTTCAGGA
TTTTGCTGCGGCCCC GTATCTAAGAATGTT CCTCCTCTTCAGGAA TTTGCTGCGGCCCCG
TATCTAAGAATGTTC CTCCTCTTCAGGAAT TTGCTGCGGCCCCGT ATCTAAGAATGTTCT
TCCTCTTCAGGAATC TGCTGCGGCCCCGTG TCTAAGAATGTTCTA CCTCTTCAGGAATCT
GCTGCGGCCCCGTGG CTAAGAATGTTCTAG CTCTTCAGGAATCTT CTGCGGCCCCGTGGG
TAAGAATGTTCTAGG TCTTCAGGAATCTTC TGCGGCCCCGTGGGG AAGAATGTTCTAGGG
CTTCAGGAATCTTCC GCGGCCCCGTGGGGT AGAATGTTCTAGGGC TTCAGGAATCTTCCT
CGGCCCCGTGGGGTA GAATGTTCTAGGGCA TCAGGAATCTTCCTG GGCCCCGTGGGGTAG
AATGTTCTAGGGCAC CAGGAATCTTCCTGA GCCCCGTGGGGTAGG ATGTTCTAGGGCACT
AGGAATCTTCCTGAA CCCCGTGGGGTAGGA TGTTCTAGGGCACTC GGAATCTTCCTGAAG
CCCGTGGGGTAGGAG GTTCTAGGGCACTCT GAATCTTCCTGAAGA CCGTGGGGTAGGAGG
TTCTAGGGCACTCTG AATCTTCCTGAAGAC CGTGGGGTAGGAGGG TCTAGGGCACTCTGG
ATCTTCCTGAAGACA GTGGGGTAGGAGGGA CTAGGGCACTCTGGG TCTTCCTGAAGACAT
TGGGGTAGGAGGGAC TAGGGCACTCTGGGA CTTCCTGAAGACATG GGGGTAGGAGGGACA
AGGGCACTCTGGGAA TTCCTGAAGACATGG GGGTAGGAGGGACAG GGGCACTCTGGGAAC
TCCTGAAGACATGGC GGTAGGAGGGACAGA GGCACTCTGGGAACC CCTGAAGACATGGCC
GTAGGAGGGACAGAG GCACTCTGGGAACCT CTGAAGACATGGCCC TAGGAGGGACAGAGA
CACTCTGGGAACCTA TGAAGACATGGCCCA AGGAGGGACAGAGAG ACTCTGGGAACCTAT
GAAGACATGGCCCAG GGAGGGACAGAGAGA CTCTGGGAACCTATA AAGACATGGCCCAGT
GAGGGACAGAGAGAC TCTGGGAACCTATAA AGACATGGCCCAGTC AGGGACAGAGAGACG
CTGGGAACCTATAAA GACATGGCCCAGTCG GGGACAGAGAGACGG TGGGAACCTATAAAG
ACATGGCCCAGTCGA GGACAGAGAGACGGG GGGAACCTATAAAGG CATGGCCCAGTCGAA
GACAGAGAGACGGGA GGAACCTATAAAGGC ATGGCCCAGTCGAAG ACAGAGAGACGGGAG
GAACCTATAAAGGCA TGGCCCAGTCGAAGG CAGAGAGACGGGAGA AACCTATAAAGGCAG
GGCCCAGTCGAAGGC AGAGAGACGGGAGAG ACCTATAAAGGCAGG GCCCAGTCGAAGGCC
GAGAGACGGGAGAGT CCTATAAAGGCAGGT CCCAGTCGAAGGCCC AGAGACGGGAGAGTC
CTATAAAGGCAGGTA CCAGTCGAAGGCCCA GAGACGGGAGAGTCA TATAAAGGCAGGTAT
CAGTCGAAGGCCCAG AGACGGGAGAGTCAG ATAAAGGCAGGTATT AGTCGAAGGCCCAGG
GACGGGAGAGTCAGC TAAAGGCAGGTATTT GTCGAAGGCCCAGGA ACGGGAGAGTCAGCC
AAAGGCAGGTATTTC TCGAAGGCCCAGGAT CGGGAGAGTCAGCCT AAGGCAGGTATTTCG
CGAAGGCCCAGGATG GGGAGAGTCAGCCTC AGGCAGGTATTTCGG GAAGGCCCAGGATGG
GGAGAGTCAGCCTCC GGCAGGTATTTCGGG AAGGCCCAGGATGGC GAGAGTCAGCCTCCA
GCAGGTATTTCGGGC AGGCCCAGGATGGCT AGAGTCAGCCTCCAC CAGGTATTTCGGGCC
GGCCCAGGATGGCTT GAGTCAGCCTCCACA AGGTATTTCGGGCCC GCCCAGGATGGCTTT
AGTCAGCCTCCACAT GGTATTTCGGGCCCT CCCAGGATGGCTTTT GTCAGCCTCCACATT
GTATTTCGGGCCCTC CCAGGATGGCTTTTG TCAGCCTCCACATTC TATTTCGGGCCCTCC
CAGGATGGCTTTTGC CAGCCTCCACATTCA ATTTCGGGCCCTCCT AGGATGGCTTTTGCT
AGCCTCCACATTCAG TTTCGGGCCCTCCTC GGATGGCTTTTGCTG GCCTCCACATTCAGA
TTCGGGCCCTCCTCT GATGGCTTTTGCTGC CCTCCACATTCAGAG TCGGGCCCTCCTCTT
ATGGCTTTTGCTGCG CTCCACATTCAGAGG CGGGCCCTCCTCTTC TGGCTTTTGCTGCGG
TCCACATTCAGAGGC GGGCCCTCCTCTTCA GGCTTTTGCTGCGGC CCACATTCAGAGGCA
CACATTCAGAGGCAT GTGTTTTGTAGTTCA AAGGCAAAGCTTTAT ACATTCAGAGGCATC
TGTTTTGTAGTTCAA AGGCAAAGCTTTATT CATTCAGAGGCATCA GTTTTGTAGTTCAAC
GGCAAAGCTTTATTT ATTCAGAGGCATCAC TTTTGTAGTTCAACA GCAAAGCTTTATTTT
TTCAGAGGCATCACA TTTGTAGTTCAACAA CAAAGCTTTATTTTC TCAGAGGCATCACAA
TTGTAGTTCAACAAC AAAGCTTTATTTTCA CAGAGGCATCACAAG TGTAGTTCAACAACT
AAGCTTTATTTTCAT AGAGGCATCACAAGT GTAGTTCAACAACTC AGCTTTATTTTCATC
GAGGCATCACAAGTA TAGTTCAACAACTCA GCTTTATTTTCATCT AGGCATCACAAGTAA
AGTTCAACAACTCAA CTTTATTTTCATCTC GGCATCACAAGTAAT GTTCAACAACTCAAG
TTTATTTTCATCTCT GCATCACAAGTAATG TTCAACAACTCAAGA TTATTTTCATCTCTC
CATCACAAGTAATGG TCAACAACTCAAGAC TATTTTCATCTCTCA ATCACAAGTAATGGC
CAACAACTCAAGACG ATTTTCATCTCTCAT TCACAAGTAATGGCA AACAACTCAAGACGA
TTTTCATCTCTCATC CACAAGTAATGGCAC ACAACTCAAGACGAA TTTCATCTCTCATCT
ACAAGTAATGGCACA CAACTCAAGACGAAG TTCATCTCTCATCTT CAAGTAATGGCACAA
AACTCAAGACGAAGC TCATCTCTCATCTTT AAGTAATGGCACAAT ACTCAAGACGAAGCT
CATCTCTCATCTTTT AGTAATGGCACAATT CTCAAGACGAAGCTT ATCTCTCATCTTTTG
GTAATGGCACAATTC TCAAGACGAAGCTTA TCTCTCATCTTTTGT TAATGGCACAATTCT
CAAGACGAAGCTTAT CTCTCATCTTTTGTC AATGGCACAATTCTT AAGACGAAGCTTATT
TCTCATCTTTTGTCC ATGGCACAATTCTTC AGACGAAGCTTATTT CTCATCTTTTGTCCT
TGGCACAATTCTTCG GACGAAGCTTATTTC TCATCTTTTGTCCTC GGCACAATTCTTCGG
ACGAAGCTTATTTCT CATCTTTTGTCCTCC GCACAATTCTTCGGA CGAAGCTTATTTCTG
ATCTTTTGTCCTCCT CACAATTCTTCGGAT GAAGCTTATTTCTGA TCTTTTGTCCTCCTT
ACAATTCTTCGGATG AAGCTTATTTCTGAG CTTTTGTCCTCCTTA CAATTCTTCGGATGA
AGCTTATTTCTGAGG TTTTGTCCTCCTTAG AATTCTTCGGATGAC GCTTATTTCTGAGGA
TTTGTCCTCCTTAGC ATTCTTCGGATGACT CTTATTTCTGAGGAT TTGTCCTCCTTAGCA
TTCTTCGGATGACTG TTATTTCTGAGGATA TGTCCTCCTTAGCAC TCTTCGGATGACTGC
TATTTCTGAGGATAA GTCCTCCTTAGCACA CTTCGGATGACTGCA ATTTCTGAGGATAAG
TCCTCCTTAGCACAA TTCGGATGACTGCAG TTTCTGAGGATAAGC CCTCCTTAGCACAAT
TCGGATGACTGCAGA TTCTGAGGATAAGCT CTCCTTAGCACAATG CGGATGACTGCAGAA
TCTGAGGATAAGCTC TCCTTAGCACAATGT GGATGACTGCAGAAA CTGAGGATAAGCTCT
CCTTAGCACAATGTA GATGACTGCAGAAAA TGAGGATAAGCTCTT CTTAGCACAATGTAA
ATGACTGCAGAAAAT GAGGATAAGCTCTTT TTAGCACAATGTAAA TGACTGCAGAAAATA
AGGATAAGCTCTTTA TAGCACAATGTAAAA GACTGCAGAAAATAG GGATAAGCTCTTTAA
AGCACAATGTAAAAA ACTGCAGAAAATAGT GATAAGCTCTTTAAA GCACAATGTAAAAAA
CTGCAGAAAATAGTG ATAAGCTCTTTAAAG CACAATGTAAAAAAG TGCAGAAAATAGTGT
TAAGCTCTTTAAAGG ACAATGTAAAAAAGA GCAGAAAATAGTGTT AAGCTCTTTAAAGGC
CAATGTAAAAAAGAA CAGAAAATAGTGTTT AGCTCTTTAAAGGCA AATGTAAAAAAGAAT
AGAAAATAGTGTTTT GCTCTTTAAAGGCAA ATGTAAAAAAGAATA GAAAATAGTGTTTTG
CTCTTTAAAGGCAAA TGTAAAAAAGAATAG AAAATAGTGTTTTGT TCTTTAAAGGCAAAG
GTAAAAAAGAATAGT AAATAGTGTTTTGTA CTTTAAAGGCAAAGC TAAAAAAGAATAGTA
AATAGTGTTTTGTAG TTTAAAGGCAAAGCT AAAAAAGAATAGTAA ATAGTGTTTTGTAGT
TTAAAGGCAAAGCTT AAAAAGAATAGTAAT TAGTGTTTTGTAGTT TAAAGGCAAAGCTTT
AAAAGAATAGTAATA AGTGTTTTGTAGTTC AAAGGCAAAGCTTTA AAAGAATAGTAATAT
AAGAATAGTAATATC GACACTGGGAGCACA TGCTTTTCTTTATAA AGAATAGTAATATCA
ACACTGGGAGCACAT GCTTTTCTTTATAAT GAATAGTAATATCAG CACTGGGAGCACATA
CTTTTCTTTATAATT AATAGTAATATCAGA ACTGGGAGCACATAG TTTTCTTTATAATTC
ATAGTAATATCAGAA CTGGGAGCACATAGA TTTCTTTATAATTCA TAGTAATATCAGAAC
TGGGAGCACATAGAG TTCTTTATAATTCAC AGTAATATCAGAACA GGGAGCACATAGAGA
TCTTTATAATTCACA GTAATATCAGAACAG GGAGCACATAGAGAT CTTTATAATTCACAC
TAATATCAGAACAGG GAGCACATAGAGATT TTTATAATTCACACA AATATCAGAACAGGA
AGCACATAGAGATTC TTATAATTCACACAT ATATCAGAACAGGAA GCACATAGAGATTCA
TATAATTCACACATA TATCAGAACAGGAAG CACATAGAGATTCAC ATAATTCACACATAT
ATCAGAACAGGAAGG ACATAGAGATTCACC TAATTCACACATATA TCAGAACAGGAAGGA
CATAGAGATTCACCC AATTCACACATATAT CAGAACAGGAAGGAG ATAGAGATTCACCCA
ATTCACACATATATG AGAACAGGAAGGAGG TAGAGATTCACCCAT TTCACACATATATGC
GAACAGGAAGGAGGA AGAGATTCACCCATG TCACACATATATGCA AACAGGAAGGAGGAA
GAGATTCACCCATGT CACACATATATGCAG ACAGGAAGGAGGAAT AGATTCACCCATGTT
ACACATATATGCAGA CAGGAAGGAGGAATG GATTCACCCATGTTT CACATATATGCAGAG
AGGAAGGAGGAATGG ATTCACCCATGTTTG ACATATATGCAGAGA GGAAGGAGGAATGGC
TTCACCCATGTTTGT CATATATGCAGAGAA GAAGGAGGAATGGCT TCACCCATGTTTGTT
ATATATGCAGAGAAG AAGGAGGAATGGCTT CACCCATGTTTGTTG TATATGCAGAGAAGA
AGGAGGAATGGCTTG ACCCATGTTTGTTGA ATATGCAGAGAAGAT GGAGGAATGGCTTGC
CCCATGTTTGTTGAA TATGCAGAGAAGATA GAGGAATGGCTTGCT CCATGTTTGTTGAAC
ATGCAGAGAAGATAT AGGAATGGCTTGCTG CATGTTTGTTGAACT TGAGAGAAGATATG
GGAATGGCTTGCTGG ATGTTTGTTGAACTT GCAGAGAAGATATGT GAATGGCTTGCTGGG
TGTTTGTTGAACTTA CAGAGAAGATATGTT AATGGCTTGCTGGGG GTTTGTTGAACTTAG
AGAGAAGATATGTTC ATGGCTTGCTGGGGA TTTGTTGAACTTAGA GAGAAGATATGTTCT
TGGCTTGCTGGGGAG TTGTTGAACTTAGAG AGAAGATATGTTCTT GGCTTGCTGGGGAGC
TGTTGAACTTAGAGT GAAGATATGTTCTTG GCTTGCTGGGGAGCC GTTGAACTTAGAGTC
AAGATATGTTCTTGT CTTGCTGGGGAGCCC TTGAACTTAGAGTCA AGATATGTTCTTGTT
TTGCTGGGGAGCCCA TGAACTTAGAGTCAT GATATGTTCTTGTTA TGCTGGGGAGCCCAT
GAACTTAGAGTCATT ATATGTTCTTGTTAA GCTGGGGAGCCCATC AACTTAGAGTCATTC
TATGTTCTTGTTAAC CTGGGGAGCCCATCC ACTTAGAGTCATTCT ATGTTCTTGTTAACA
TGGGGAGCCCATCCA CTTAGAGTCATTCTC TGTTCTTGTTAACAT GGGGAGCCCATCCAG
TTAGAGTCATTCTCA GTTCTTGTTAACATT GGGAGCCCATCCAGG TAGAGTCATTCTCAT
TTCTTGTTAACATTG GGAGCCCATCCAGGA AGAGTCATTCTCATG TCTTGTTAACATTGT
GAGCCCATCCAGGAC GAGTCATTCTCATGC CTTGTTAACATTGTA AGCCCATCCAGGACA
AGTCATTCTCATGCT TTGTTAACATTGTAT GCCCATCCAGGACAC GTCATTCTCATGCTT
TGTTAACATTGTATA CCCATCCAGGACACT TCATTCTCATGCTTT GTTAACATTGTATAC
CCATCCAGGACACTG CATTCTCATGCTTTT TTAACATTGTATACA CATCCAGGACACTGG
ATTCTCATGCTTTTC TAACATTGTATACAA ATCCAGGACACTGGG TTCTCATGCTTTTCT
AACATTGTATACAAC TCCAGGACACTGGGA TCTCATGCTTTTCTT ACATTGTATACAACA
CCAGGACACTGGGAG CTCATGCTTTTCTTT CATTGTATACAACAT CAGGACACTGGGAGC
TCATGCTTTTCTTTA ATTGTATACAACATA AGGACACTGGGAGCA CATGCTTTTCTTTAT
TTGTATACAACATAG GGACACTGGGAGCAC ATGCTTTTCTTTATA TGTATACAACATAGC
GTATACAACATAGCC TGTTAGAGATGCTAT CCAGAGACTGGGCTG TATACAACATAGCCC
GTTAGAGATGCTATA CAGAGACTGGGCTGC ATACAACATAGCCCC TTAGAGATGCTATAT
AGAGACTGGGCTGCT TACAACATAGCCCCA TAGAGATGCTATATG GAGACTGGGCTGCTC
ACAACATAGCCCCAA AGAGATGCTATATGA AGACTGGGCTGCTCT CAACATAGCCCCAAA
GAGATGCTATATGAT GACTGGGCTGCTCTC AACATAGCCCCAAAT AGATGCTATATGATA
ACTGGGCTGCTCTCC ACATAGCCCCAAATA GATGCTATATGATAC CTGGGCTGCTCTCCC
CATAGCCCCAAATAT ATGCTATATGATACA TGGGCTGCTCTCCCG ATAGCCCCAAATATA
TGCTATATGATACAA GGGCTGCTCTCCCGG TAGCCCCAAATATAG GCTATATGATACAAC
GGCTGCTCTCCCGGA AGCCCCAAATATAGT CTATATGATACAACT GCTGCTCTCCCGGAG
GCCCCAAATATAGTA TATATGATACAACTG CTGCTCTCCCGGAGG CCCCAAATATAGTAA
ATATGATACAACTGT TGCTCTCCCGGAGGC CCCAAATATAGTAAG TATGATACAACTGTG
GCTCTCCCGGAGGCC CCAAATATAGTAAGA ATGATACAACTGTGG CTCTCCCGGAGGCCA
CAAATATAGTAAGAT TGATACAACTGTGGC TCTCCCGGAGGCCAA AAATATAGTAAGATC
GATACAACTGTGGCC CTCCCGGAGGCCAAA AATATAGTAAGATCT ATACAACTGTGGCCA
TCCCGGAGGCCAAAC ATATAGTAAGATCTA TACAACTGTGGCCAT CCCGGAGGCCAAACC
TATAGTAAGATCTAT ACAACTGTGGCCATG CCGGAGGCCAAACCC ATAGTAAGATCTATA
CAACTGTGGCCATGA CGGAGGCCAAACCCA TAGTAAGATCTATAC AACTGTGGCCATGAC
GGAGGCCAAACCCAA AGTAAGATCTATACT ACTGTGGCCATGACT GAGGCCAAACCCAAG
GTAAGATCTATACTA CTGTGGCCATGACTG AGGCCAAACCCAAGA TAAGATCTATACTAG
TGTGGCCATGACTGA GGCCAAACCCAAGAA AAGATCTATACTAGA GTGGCCATGACTGAG
GCCAAACCCAAGAAG AGATCTATACTAGAT TGGCCATGACTGAGG CCAAACCCAAGAAGG
GATCTATACTAGATA GGCCATGACTGAGGA CAAACCCAAGAAGGT ATCTATACTAGATAA
GCCATGACTGAGGAA AAACCCAAGAAGGTC TCTATACTAGATAAT CCATGACTGAGGAAA
AACCCAAGAAGGTCT CTATACTAGATAATC CATGACTGAGGAAAG ACCCAAGAAGGTCTG
TATACTAGATAATCC ATGACTGAGGAAAGG CCCAAGAAGGTCTGG ATACTAGATAATCCT
TGACTGAGGAAAGGA CCAAGAAGGTCTGGC TACTAGATAATCCTA GACTGAGGAAAGGAG
CAAGAAGGTCTGGCA ACTAGATAATCCTAG ACTGAGGAAAGGAGC AAGAAGGTCTGGCAA
CTAGATAATCCTAGA CTGAGGAAAGGAGCT AGAAGGTCTGGCAAA TAGATAATCCTAGAT
TGAGGAAAGGAGCTC GAAGGTCTGGCAAAG AGATAATCCTAGATG GAGGAAAGGAGCTCA
AAGGTCTGGCAAAGT GATAATCCTAGATGA AGGAAAGGAGCTCAC AGGTCTGGCAAAGTC
ATAATCCTAGATGAA GGAAAGGAGCTCACG GGTCTGGCAAAGTCA TAATCCTAGATGAAA
GAAAGGAGCTCACGC GTCTGGCAAAGTCAG AATCCTAGATGAAAT AAAGGAGCTCACGCC
TCTGGCAAAGTCAGG ATCCTAGATGAAATG AAGGAGCTCACGCCC CTGGCAAAGTCAGGC
TCCTAGATGAAATGT AGGAGCTCACGCCCA TGGCAAAGTCAGGCT CCTAGATGAAATGTT
GGAGCTCACGCCCAG GGCAAAGTCAGGCTC CTAGATGAAATGTTA GAGCTCACGCCCAGA
GCAAAGTCAGGCTCA TAGATGAAATGTTAG AGCTCACGCCCAGAG CAAAGTCAGGCTCAG
AGATGAAATGTTAGA GCTCACGCCCAGAGA AAAGTCAGGCTCAGG GATGAAATGTTAGAG
CTCACGCCCAGAGAC AAGTCAGGCTCAGGG ATGAAATGTTAGAGA TCACGCCCAGAGACT
AGTCAGGCTCAGGGA
TGAAATGTTAGAGAT CACGCCCAGAGACTG GTCAGGCTCAGGGAG GAAATGTTAGAGATG
ACGCCCAGAGACTGG TCAGGCTCAGGGAGA AAATGTTAGAGATGC CGCCCAGAGACTGGG
CAGGCTCAGGGAGAC AATGTTAGAGATGCT GCCCAGAGACTGGGC AGGCTCAGGGAGACT
ATGTTAGAGATGCTA CCCAGAGACTGGGCT GGCTCAGGGAGACTC GCTCAGGGAGACTCT
CTCTCCTTGAAAACA TATTTTTTTAACTTT CTCAGGGAGACTCTG TCTCCTTGAAAACAG
ATTTTTTTAACTTTT TCAGGGAGACTCTGC CTCCTTGAAAACAGA TTTTTTTAACTTTTT
CAGGGAGACTCTGCC TCCTTGAAAACAGAG TTTTTTAACTTTTTG AGGGAGACTCTGCCC
CCTTGAAAACAGAGG TTTTTAACTTTTTGG GGGAGACTCTGCCCT CTTGAAAACAGAGGG
TTTTAACTTTTTGGG GGAGACTCTGCCCTG TTGAAAACAGAGGGG TTTAACTTTTTGGGG
GAGACTCTGCCCTGC TGAAAACAGAGGGGT TTAACTTTTTGGGGG AGACTCTGCCCTGCT
GAAAACAGAGGGGTC TAACTTTTTGGGGGG GACTCTGCCCTGCTG AAAACAGAGGGGTCT
AACTTTTTGGGGGGA ACTCTGCCCTGCTGC AAACAGAGGGGTCTC ACTTTTTGGGGGGAA
CTCTGCCCTGCTGCA AACAGAGGGGTCTCA CTTTTTGGGGGGAAA TCTGCCCTGCTGCAG
ACAGAGGGGTCTCAA TTTTTGGGGGGAAAA CTGCCCTGCTGCAGA CAGAGGGGTCTCAAG
TTTTGGGGGGAAAAG TGCCCTGCTGCAGAC AGAGGGGTCTCAAGA TTTGGGGGGAAAAGT
GCCCTGCTGCAGACC GAGGGGTCTCAAGAC TTGGGGGGAAAAGTA CCCTGCTGCAGACCT
AGGGGTCTCAAGACA TGGGGGGAAAAGTAT CCTGCTGCAGACCTC GGGGTCTCAAGACAT
GGGGGGAAAAGTATT CTGCTGCAGACCTCG GGGTCTCAAGACATT GGGGGAAAAGTATTT
TGCTGCAGACCTCGG GGTCTCAAGACATTC GGGGAAAAGTATTTT GCTGCAGACCTCGGT
GTCTCAAGACATTCT GGGAAAAGTATTTTT CTGCAGACCTCGGTG TCTCAAGACATTCTG
GGAAAAGTATTTTTG TGCAGACCTCGGTGT CTCAAGACATTCTGC GAAAAGTATTTTTGA
GCAGACCTCGGTGTG TCAAGACATTCTGCC AAAAGTATTTTTGAG CAGACCTCGGTGTGG
CAAGACATTCTGCCT AAAGTATTTTTGAGA AGACCTCGGTGTGGA AAGACATTCTGCCTA
AAGTATTTTTGAGAA GACCTCGGTGTGGAC AGACATTCTGCCTAC AGTATTTTTGAGAAG
ACCTCGGTGTGGACA GACATTCTGCCTACC GTATTTTTGAGAAGT CCTCGGTGTGGACAC
ACATTCTGCCTACCT TATTTTTGAGAAGTT CTCGGTGTGGACACA CATTCTGCCTACCTA
ATTTTTGAGAAGTTT TCGGTGTGGACACAC ATTCTGCCTACCTAT TTTTTGAGAAGTTTG
CGGTGTGGACACACG TTCTGCCTACCTATT TTTTGAGAAGTTTGT GGTGTGGACACACGC
TCTGCCTACCTATTA TTTGAGAAGTTTGTC GTGTGGACACACGCT CTGCCTACCTATTAG
TTGAGAAGTTTGTCT TGTGGACACACGCTG TGCCTACCTATTAGC TGAGAAGTTTGTCTT
GTGGACACACGCTGC GCCTACCTATTAGCT GAGAAGTTTGTCTTG TGGACACACGCTGCA
CCTACCTATTAGCTT AGAAGTTTGTCTTGC GGACACACGCTGCAT CTACCTATTAGCTTT
GAAGTTTGTCTTGCA GACACACGCTGCATA TACCTATTAGCTTTT AAGTTTGTCTTGCAA
ACACACGCTGCATAG ACCTATTAGCTTTTC AGTTTGTCTTGCAAT CACACGCTGCATAGA
CCTATTAGCTTTTCT GTTTGTCTTGCAATG ACACGCTGCATAGAG CTATTAGCTTTTCTT
TTTGTCTTGCAATGT CACGCTGCATAGAGC TATTAGCTTTTCTTT TTGTCTTGCAATGTA
ACGCTGCATAGAGCT ATTAGCTTTTCTTTA TGTCTTGCAATGTAT CGCTGCATAGAGCTC
TTAGCTTTTCTTTAT GTCTTGCAATGTATT GCTGCATAGAGCTCT TAGCTTTTCTTTATT
TCTTGCAATGTATTT CTGCATAGAGCTCTC AGCTTTTCTTTATTT CTTGCAATGTATTTA
TGCATAGAGCTCTCC GCTTTTCTTTATTTT TTGCAATGTATTTAT GCATAGAGCTCTCCT
CTTTTCTTTATTTTT TGCAATGTATTTATA CATAGAGCTCTCCTT TTTTCTTTATTTTTT
GCAATGTATTTATAA ATAGAGCTCTCCTTG TTTCTTTATTTTTTT CAATGTATTTATAAA
TAGAGCTCTCCTTGA TTCTTTATTTTTTTA AATGTATTTATAAAT AGAGCTCTCCTTGAA
TCTTTATTTTTTTAA ATGTATTTATAAATA GAGCTCTCCTTGAAA CTTTATTTTTTTAAC
TGTATTTATAAATAG AGCTCTCCTTGAAAA TTTATTTTTTTAACT GTATTTATAAATAGT
GCTCTCCTTGAAAAC TTATTTTTTTAACTT TATTTATAAATAGTA ATTTATAAATAGTAA
TTTATAAATAGTAAA TTATAAATAGTAAAT TATAAATAGTAAATA ATAAATAGTAAATAA
TAAATAGTAAATAAA AAATAGTAAATAAAG AATAGTAAATAAAGT ATAGTAAATAAAGTT
TAGTAAATAAAGTTT AGTAAATAAAGTTTT GTAAATAAAGTTTTT TAAATAAAGTTTTTA
AAATAAAGTTTTTAC AATAAAGTTTTTACC ATAAAGTTTTTACCA TAAAGTTTTTACCAT
AAAGTTTTTACCATT
EXAMPLE 8
Antisense Oligonucleotides of IGF-I Receptor
[0058] Antisense oligonucleotides to IGF-I may selected from
molecules capable of interacting with one or the following sense
oligonucleotides:
6 TTTTTTTTTTTTTTG TCATCCCAAATAAAA GGCTCCGGAGGAGGG TTTTTTTTTTTTTGA
CATCCCAAATAAAAG GCTCCGGAGGAGGGT TTTTTTTTTTTTGAG ATCCCAAATAAAAGG
CTCCGGAGGAGGGTC TTTTTTTTTTTGAGA TCCCAAATAAAAGGA TCCGGAGGAGGGTCC
TTTTTTTTTTGAGAA CCCAAATAAAAGGAA CCGGAGGAGGGTCCC TTTTTTTTTGAGAAA
CCAAATAAAAGGAAT CGGAGGAGGGTCCCC TTTTTTTTGAGAAAG CAAATAAAAGGAATG
GGAGGAGGGTCCCCG TTTTTTTGAGAAAGG AAATAAAAGGAATGA GAGGAGGGTCCCCGA
TTTTTTGAGAAAGGG AATAAAAGGAATGAA AGGAGGGTCCCCGAC TTTTTGAGAAAGGGA
ATAAAAGGAATGAAG GGAGGGTCCCCGACC TTTTGAGAAAGGGAA TAAAAGGAATGAAGT
GAGGGTCCCCGACCT TTTGAGAAAGGGAAT AAAAGGAATGAAGTC AGGGTCCCCGACCTC
TTGAGAAAGGGAATT AAAGGAATGAAGTCT GGGTCCCCGACCTCG TGAGAAAGGGAATTT
AAGGAATGAAGTCTG GGTCCCCGACCTCGC GAGAAAGGGAATTTC AGGAATGAAGTCTGG
GTCCCCGACCTCGCT AGAAAGGGAATTTCA GGAATGAAGTCTGGC TCCCCGACCTCGCTG
GAAAGGGAATTTCAT GAATGAAGTCTGGCT CCCCGACCTCGCTGT AAAGGGAATTTCATC
AATGAAGTCTGGCTC CCCGACCTCGCTGTG AAGGGAATTTCATCC ATGAAGTCTGGCTCC
CCGACCTCGCTGTGG AGGGAATTTCATCCC TGAAGTCTGGCTCCG CGACCTCGCTGTGGG
GGGAATTTCATCCCA GAAGTCTGGCTCCGG GACCTCGCTGTGGGG GGAATTTCATCCCAA
AAGTCTGGCTCCGGA ACCTCGCTGTGGGGG GAATTTCATCCCAAA AGTCTGGCTCCGGAG
CCTCGCTGTGGGGGC AATTTCATCCCAAAT GTCTGGCTCCGGAGG CTCGCTGTGGGGGCT
ATTTCATCCCAAATA TCTGGCTCCGGAGGA TCGCTGTGGGGGCTC TTTCATCCCAAATAA
CTGGCTCCGGAGGAG CGCTGTGGGGGCTCC TTCATCCCAAATAAA TGGCTCCGGAGGAGG
GCTGTGGGGGCTCCT CTGTGGGGGCTCCTG AATCTGCGGGCCAGG AGAACTGCACGGTGA
TGTGGGGGCTCCTGT ATCTGCGGGCCAGGC GAACTGCACGGTGAT GTGGGGGCTCCTGTT
TCTGCGGGCCAGGCA AACTGCACGGTGATC TGGGGGCTCCTGTTT CTGCGGGCCAGGCAT
ACTGCACGGTGATCG GGGGGCTCCTGTTTC TGCGGGCCAGGCATC CTGCACGGTGATCGA
GGGGCTCCTGTTTCT GCGGGCCAGGCATCG TGCACGGTGATCGAG GGGCTCCTGTTTCTC
CGGGCCAGGCATCGA GCACGGTGATCGAGG GGCTCCTGTTTCTCT GGGCCAGGCATCGAC
CACGGTGATCGAGGG GCTCCTGTTTCTCTC GGCCAGGCATCGACA ACGGTGATCGAGGGC
CTCCTGTTTCTCTCC GCCAGGCATCGACAT CGGTGATCGAGGGCT TCCTGTTTCTCTCCG
CCAGGCATCGACATC GGTGATCGAGGGCTA CCTGTTTCTCTCCGC CAGGCATCGACATCC
GTGATCGAGGGCTAC CTGTTTCTCTCCGCC AGGCATCGACATCCG TGATCGAGGGCTACC
TGTTTCTCTCCGCCG GGCATCGACATCCGC GATCGAGGGCTACCT GTTTCTCTCCGCCGC
GCATCGACATCCGCA ATCGAGGGCTACCTC TTTCTCTCCGCCGCG CATCGACATCCGCAA
TCGAGGGCTACCTCC TTCTCTCCGCCGCGC ATCGACATCCGCAAC CGAGGGCTACCTCCA
TCTCTCCGCCGCGCT TCGACATCCGCAACG GAGGGCTACCTCCAC CTCTCCGCCGCGCTC
CGACATCCGCAACGA AGGGCTACCTCCACA TCTCCGCCGCGCTCT GACATCCGCAACGAC
GGGCTACCTCCACAT CTCCGCCGCGCTCTC ACATCCGCAACGACT GGCTACCTCCACATC
TCCGCCGCGCTCTCG CATCCGCAACGACTA GCTACCTCCACATCC CCGCCGCGCTCTCGC
ATCCGCAACGACTAT CTACCTCCACATCCT CGCCGCGCTCTCGCT TCCGCAACGACTATC
TACCTCCACATCCTG GCCGCGCTCTCGCTC CCGCAACGACTATCA ACCTCCACATCCTGC
CCGCGCTCTCGCTCT CGCAACGACTATCAG CCTCCACATCCTGCT CGCGCTCTCGCTCTG
GCAACGACTATCAGC CTCCACATCCTGCTC GCGCTCTCGCTCTGG CAACGACTATCAGCA
TCCACATCCTGCTCA CGCTCTCGCTCTGGC AACGACTATCAGCAG CCACATCCTGCTCAT
GCTCTCGCTCTGGCC ACGACTATCAGCAGC CACATCCTGCTCATC CTCTCGCTCTGGCCG
CGACTATCAGCAGCT ACATCCTGCTCATCT TCTCGCTCTGGCCGA GACTATCAGCAGCTG
CATCCTGCTCATCTC CTCGCTCTGGCCGAC ACTATCAGCAGCTGA ATCCTGCTCATCTCC
TCGCTCTGGCCGACG CTATCAGCAGCTGAA TCCTGCTCATCTCCA CGCTCTGGCCGACGA
TATCAGCAGCTGAAG CCTGCTCATCTCCAA GCTCTGGCCGACGAG ATCAGCAGCTGAAGC
CTGCTCATCTCCAAG CTCTGGCCGACGAGT TCAGCAGCTGAAGCG TGCTCATCTCCAAGG
TCTGGCCGACGAGTG CAGCAGCTGAAGCGC GCTCATCTCCAAGGC CTGGCCGACGAGTGG
AGCAGCTGAAGCGCC CTCATCTCCAAGGCC TGGCCGACGAGTGGA GCAGCTGAAGCGCCT
TCATCTCCAAGGCCG GGCCGACGAGTGGAG CAGCTGAAGCGCCTG CATCTCCAAGGCCGA
GCCGACGAGTGGAGA AGCTGAAGCGCCTGG ATCTCCAAGGCCGAG CCGACGAGTGGAGAA
GCTGAAGCGCCTGGA TCTCCAAGGCCGAGG CGACGAGTGGAGAAA CTGAAGCGCCTGGAG
CTCCAAGGCCGAGGA GACGAGTGGAGAAAT TGAAGCGCCTGGAGA TCCAAGGCCGAGGAC
ACGAGTGGAGAAATC GAAGCGCCTGGAGAA CCAAGGCCGAGGACT CGAGTGGAGAAATCT
AAGCGCCTGGAGAAC CAAGGCCGAGGACTA GAGTGGAGAAATCTG AGCGCCTGGAGAACT
AAGGCCGAGGACTAC AGTGGAGAAATCTGC GCGCCTGGAGAACTG AGGCCGAGGACTACC
GTGGAGAAATCTGCG CGCCTGGAGAACTGC GGCCGAGGACTACCG TGGAGAAATCTGCGG
GCCTGGAGAACTGCA GCCGAGGACTACCGC GGAGAAATCTGCGGG CCTGGAGAACTGCAC
CCGAGGACTACCGCA GAGAAATCTGCGGGC CTGGAGAACTGCACG CGAGGACTACCGCAG
AGAAATCTGCGGGCC TGGAGAACTGCACGG GAGGACTACCGCAGC GAAATCTGCGGGCCA
GGAGAACTGCACGGT AGGACTACCGCAGCT AAATCTGCGGGCCAG GAGAACTGCACGGTG
GGACTACCGCAGCTA GACTACCGCAGCTAC GTTCCGAGTGGCTGG TCCGCGGCTGGAAAC
ACTACCGCAGCTACC TTCCGAGTGGCTGGC CCGCGGCTGGAAACT CTACCGCAGCTACCG
TCCGAGTGGCTGGCC CGCGGCTGGAAACTC TACCGCAGCTACCGC CCGAGTGGCTGGCCT
GCGGCTGGAAACTCT ACCGCAGCTACCGCT CGAGTGGCTGGCCTC CGGCTGGAAACTCTT
CCGCAGCTACCGCTT GAGTGGCTGGCCTCG GGCTGGAAACTCTTC CGCAGCTACCGCTTC
AGTGGCTGGCCTCGA GCTGGAAACTCTTCT GCAGCTACCGCTTCC GTGGCTGGCCTCGAG
CTGGAAACTCTTCTA CAGCTACCGCTTCCC TGGCTGGCCTCGAGA TGGAAACTCTTCTAC
AGCTACCGCTTCCCC GGCTGGCCTCGAGAG GGAAACTCTTCTACA GCTACCGCTTCCCCA
GCTGGCCTCGAGAGC GAAACTCTTCTACAA CTACCGCTTCCCCAA CTGGCCTCGAGAGCC
AAACTCTTCTACAAC TACCGCTTCCCCAAG TGGCCTCGAGAGCCT AACTCTTCTACAACT
ACCGCTTCCCCAAGC GGCCTCGAGAGCCTC ACTCTTCTACAACTA CCGCTTCCCCAAGCT
GCCTCGAGAGCCTCG CTCTTCTACAACTAC CGCTTCCCCAAGCTC CCTCGAGAGCCTCGG
TCTTCTACAACTACG GCTTCCCCAAGCTCA CTCGAGAGCCTCGGA CTTCTACAACTACGC
CTTCCCCAAGCTCAC TCGAGAGCCTCGGAG TTCTACAACTACGCC TTCCCCAAGCTCACG
CGAGAGCCTCGGAGA TCTACAACTACGCCC TCCCCAAGCTCACGG GAGAGCCTCGGAGAC
CTACAACTACGCCCT CCCCAAGCTCACGGT AGAGCCTCGGAGACC TACAACTACGCCCTG
CCCAAGCTCACGGTC GAGCCTCGGAGACCT ACAACTACGCCCTGG CCAAGCTCACGGTCA
AGCCTCGGAGACCTC CAACTACGCCCTGGT CAAGCTCACGGTCAT GCCTCGGAGACCTCT
AACTACGCCCTGGTC AAGCTCACGGTCATT CCTCGGAGACCTCTT ACTACGCCCTGGTCA
AGCTCACGGTCATTA CTCGGAGACCTCTTC CTACGCCCTGGTCAT GCTCACGGTCATTAC
TCGGAGACCTCTTCC TACGCCCTGGTCATC CTCACGGTCATTACC CGGAGACCTCTTCCC
ACGCCCTGGTCATCT TCACGGTCATTACCG GGAGACCTCTTCCCC CGCCCTGGTCATCTT
CACGGTCATTACCGA GAGACCTCTTCCCCA GCCCTGGTCATCTTC ACGGTCATTACCGAG
AGACCTCTTCCCCAA CCCTGGTCATCTTCG CGGTCATTACCGAGT GACCTCTTCCCCAAC
CCTGGTCATCTTCGA GGTCATTACCGAGTA ACCTCTTCCCCAACC CTGGTCATCTTCGAG
GTCATTACCGAGTAC CCTCTTCCCCAACCT TGGTCATCTTCGAGA TCATTACCGAGTACT
CTCTTCCCCAACCTC GGTCATCTTCGAGAT CATTACCGAGTACTT TCTTCCCCAACCTCA
GTCATCTTCGAGATG ATTACCGAGTACTTG CTTCCCCAACCTCAC TCATCTTCGAGATGA
TTACCGAGTACTTGC TTCCCCAACCTCACG CATCTTCGAGATGAC TACCGAGTACTTGCT
TCCCCAACCTCACGG ATCTTCGAGATGACC ACCGAGTACTTGCTG CCCCAACCTCACGGT
TCTTCGAGATGACCA CCGAGTACTTGCTGC CCCAACCTCACGGTC CTTCGAGATGACCAA
CGAGTACTTGCTGCT CCAACCTCACGGTCA TTCGAGATGACCAAT GAGTACTTGCTGCTG
CAACCTCACGGTCAT TCGAGATGACCAATC AGTACTTGCTGCTGT AACCTCACGGTCATC
CGAGATGACCAATCT GTACTTGCTGCTGTT ACCTCACGGTCATCC GAGATGACCAATCTC
TACTTGCTGCTGTTC CCTCACGGTCATCCG AGATGACCAATCTCA ACTTGCTGCTGTTCC
CTCACGGTCATCCGC GATGACCAATCTCAA CTTGCTGCTGTTCCG TCACGGTCATCCGCG
ATGACCAATCTCAAG TTGCTGCTGTTCCGA CACGGTCATCCGCGG TGACCAATCTCAAGG
TGCTGCTGTTCCGAG ACGGTCATCCGCGGC GACCAATCTCAAGGA GCTGCTGTTCCGAGT
CGGTCATCCGCGGCT ACCAATCTCAAGGAT CTGCTGTTCCGAGTG GGTCATCCGCGGCTG
CCAATCTCAAGGATA TGCTGTTCCGAGTGG GTCATCCGCGGCTGG CAATCTCAAGGATAT
GCTGTTCCGAGTGGC TCATCCGCGGCTGGA AATCTCAAGGATATT CTGTTCCGAGTGGCT
CATCCGCGGCTGGAA ATCTCAAGGATATTG TGTTCCGAGTGGCTG ATCCGCGGCTGGAAA
TCTCAAGGATATTGG CTCAAGGATATTGGG TGAGAAAAATGCTGA ATGCGGTGTCCAATA
TCAAGGATATTGGGC GAGAAAAATGCTGAC TGCGGTGTCCAATAA CAAGGATATTGGGCT
AGAAAAATGCTGACC GCGGTGTCCAATAAC AAGGATATTGGGCTT GAAAAATGCTGACCT
CGGTGTCCAATAACT AGGATATTGGGCTTT AAAAATGCTGACCTC GGTGTCCAATAACTA
GGATATTGGGCTTTA AAAATGCTGACCTCT GTGTCCAATAACTAC GATATTGGGCTTTAC
AAATGCTGACCTCTG TGTCCAATAACTACA ATATTGGGCTTTACA AATGCTGACCTCTGT
GTCCAATAACTACAT TATTGGGCTTTACAA ATGCTGACCTCTGTT TCCAATAACTACATT
ATTGGGCTTTACAAC TGCTGACCTCTGTTA CCAATAACTACATTG TTGGGCTTTACAACC
GCTGACCTCTGTTAC CAATAACTACATTGT TGGGCTTTACAACCT CTGACCTCTGTTACC
AATAACTACATTGTG GGGCTTTACAACCTG TGACCTCTGTTACCT ATAACTACATTGTGG
GGCTTTACAACCTGA GACCTCTGTTACCTC TAACTACATTGTGGG GCTTTACAACCTGAG
ACCTCTGTTACCTCT AACTACATTGTGGGG CTTTACAACCTGAGG CCTCTGTTACCTCTC
ACTACATTGTGGGGA TTTACAACCTGAGGA CTCTGTTACCTCTCC CTACATTGTGGGGAA
TTACAACCTGAGGAA TCTGTTACCTCTCCA TACATTGTGGGGAAT TACAACCTGAGGAAC
CTGTTACCTCTCCAC ACATTGTGGGGAATA ACAACCTGAGGAACA TGTTACCTCTCCACT
CATTGTGGGGAATAA CAACCTGAGGAACAT GTTACCTCTCCACTG ATTGTGGGGAATAAG
AACCTGAGGAACATT TTACCTCTCCACTGT TTGTGGGGAATAAGC ACCTGAGGAACATTA
TACCTCTCCACTGTG TGTGGGGAATAAGCC CCTGAGGAACATTAC ACCTCTCCACTGTGG
GTGGGGAATAAGCCC CTGAGGAACATTACT CCTCTCCACTGTGGA TGGGGAATAAGCCCC
TGAGGAACATTACTC CTCTCCACTGTGGAC GGGGAATAAGCCCCC GAGGAACATTACTCG
TCTCCACTGTGGACT GGGAATAAGCCCCCA AGGAACATTACTCGG CTCCACTGTGGACTG
GGAATAAGCCCCCAA GGAACATTACTCGGG TCCACTGTGGACTGG GAATAAGCCCCCAAA
GAACATTACTCGGGG CCACTGTGGACTGGT AATAAGCCCCCAAAG AACATTACTCGGGGG
CACTGTGGACTGGTC ATAAGCCCCCAAAGG ACATTACTCGGGGGG ACTGTGGACTGGTCC
TAAGCCCCCAAAGGA CATTACTCGGGGGGC CTGTGGACTGGTCCC AAGCCCCCAAAGGAA
ATTACTCGGGGGGCC TGTGGACTGGTCCCT AGCCCCCAAAGGAAT TTACTCGGGGGGCCA
GTGGACTGGTCCCTG GCCCCCAAAGGAATG TACTCGGGGGGCCAT TGGACTGGTCCCTGA
CCCCCAAAGGAATGT ACTCGGGGGGCCATC GGACTGGTCCCTGAT CCCCAAAGGAATGTG
CTCGGGGGGCCATCA GACTGGTCCCTGATC CCCAAAGGAATGTGG TCGGGGGGCCATCAG
ACTGGTCCCTGATCC CCAAAGGAATGTGGG CGGGCGGCCATCAGG CTGGTCCCTGATCCT
CAAAGGAATGTGGGG GGGGGGCCATCAGGA TGGTCCCTGATCCTG AAAGGAATGTGGGGA
GGGGGCCATCAGGAT GGTCCCTGATCCTGG AAGGAATGTGGGGAC GGGGCCATCAGGATT
GTCCCTGATCCTGGA AGGAATGTGGGGACC GGGCCATCAGGATTG TCCCTGATCCTGGAT
GGAATGTGGGGACCT GGCCATCAGGATTGA CCCTGATCCTGGATG GAATGTGGGGACCTG
GCCATCAGGATTGAG CCTGATCCTGGATGC AATGTGGGGACCTGT CCATCAGGATTGAGA
CTGATCCTGGATGCG ATGTGGGGACCTGTG CATCAGGATTGAGAA TGATCCTGGATGCGG
TGTGGGGACCTGTGT ATCAGGATTGAGAAA GATCCTGGATGCGGT GTGGGGACCTGTGTC
TCAGGATTGAGAAAA ATCCTGGATGCGGTG TGGGGACCTGTGTCC CAGGATTGAGAAAAA
TCCTGGATGCGGTGT GGGGACCTGTGTCCA AGGATTGAGAAAAAT CCTGGATGCGGTGTC
GGGACCTGTGTCCAG GGATTGAGAAAAATG CTGGATGCGGTGTCC GGACCTGTGTCCAGG
GATTGAGAAAAATGC TGGATGCGGTGTCCA GACCTGTGTCCAGGG ATTGAGAAAAATGCT
GGATGCGGTGTCCAA ACCTGTGTCCAGGGA TTGAGAAAAATGCTG GATGCGGTGTCCAAT
CCTGTGTCCAGGGAC CTGTGTCCAGGGACC TGAGTACAACTACCG CGTGTGGGAAGCGGG
TGTGTCCAGGGACCA GAGTACAACTACCGC GTGTGGGAAGCGGGC GTGTCCAGGGACCAT
AGTACAACTACCGCT TGTGGGAAGCGGGCG TGTCCAGGGACCATG GTACAACTACCGCTG
GTGGGAAGCGGGCGT GTCCAGGGACCATGG TACAACTACCGCTGC TGGGAAGCGGGCGTG
TCCAGGGACCATGGA ACAACTACCGCTGCT GGGAAGCGGGCGTGC CCAGGGACCATGGAG
CAACTACCGCTGCTG GGAAGCGGGCGTGCA CAGGGACCATGGAGG AACTACCGCTGCTGG
GAAGCGGGCGTGCAC AGGGACCATGGAGGA ACTACCGCTGCTGGA AAGCGGGCGTGCACC
GGGACCATGGAGGAG CTACCGCTGCTGGAC AGCGGGCGTGCACCG GGACCATGGAGGAGA
TACCGCTGCTGGACC GCGGGCGTGCACCGA GACCATGGAGGAGAA ACCGCTGCTGGACCA
CGGGCGTGCACCGAG ACCATGGAGGAGAAG CCGCTGCTGGACCAC GGGCGTGCACCGAGA
CCATGGAGGAGAAGC CGCTGCTGGACCACA GGCGTGCACCGAGAA CATGGAGGAGAAGCC
GCTGCTGGACCACAA GCGTGCACCGAGAAC ATGGAGGAGAAGCCG CTGCTGGACCACAAA
CGTGCACCGAGAACA TGGAGGAGAAGCCGA TGCTGGACCACAAAC GTGCACCGAGAACAA
GGAGGAGAAGCCGAT GCTGGACCACAAACC TGCACCGAGAACAAT GAGGAGAAGCCGATG
CTGGACCACAAACCG GCACCGAGAACAATG AGGAGAAGCCGATGT TGGACCACAAACCGC
CACCGAGAACAATGA GGAGAAGCCGATGTG GGACCACAAACCGCT ACCGAGAACAATGAG
GAGAAGCCGATGTGT GACCACAAACCGCTG CCGAGAACAATGAGT AGAAGCCGATGTGTG
ACCACAAACCGCTGC CGAGAACAATGAGTG GAAGCCGATGTGTGA CCACAAACCGCTGCC
GAGAACAATGAGTGC AAGCCGATGTGTGAG CACAAACCGCTGCCA AGAACAATGAGTGCT
AGCCGATGTGTGAGA ACAAACCGCTGCCAG GAACAATGAGTGCTG GCCGATGTGTGAGAA
CAAACCGCTGCCAGA AACAATGAGTGCTGC CCGATGTGTGAGAAG AAACCGCTGCCAGAA
ACAATGAGTGCTGCC CGATGTGTGAGAAGA AACCGCTGCCAGAAA CAATGAGTGCTGCCA
GATGTGTGAGAAGAC ACCGCTGCCAGAAAA AATGAGTGCTGCCAC ATGTGTGAGAAGACC
CCGCTGCCAGAAAAT ATGAGTGCTGCCACC TGTGTGAGAAGACCA CGCTGCCAGAAAATG
TGAGTGCTGCCACCC GTGTGAGAAGACCAC GCTGCCAGAAAATGT GAGTGCTGCCACCCC
TGTGAGAAGACCACC CTGCCAGAAAATGTG AGTGCTGCCACCCCG GTGAGAAGACCACCA
TGCCAGAAAATGTGC GTGCTGCCACCCCGA TGAGAAGACCACCAT GCCAGAAAATGTGCC
TGCTGCCACCCCGAG GAGAAGACCACCATC CCAGAAAATGTGCCC GCTGCCACCCCGAGT
AGAAGACCACCATCA CAGAAAATGTGCCCA CTGCCACCCCGAGTG GAAGACCACCATCAA
AGAAAATGTGCCCAA TGCCACCCCGAGTGC AAGACCACCATCAAC GAAAATGTGCCCAAG
GCCACCCCGAGTGCC AGACCACCATCAACA AAAATGTGCCCAAGC CCACCCCGAGTGCCT
GACCACCATCAACAA AAATGTGCCCAAGCA CACCCCGAGTGCCTG ACCACCATCAACAAT
AATGTGCCCAAGCAC ACCCCGAGTGCCTGG CCACCATCAACAATG ATGTGCCCAAGCACG
CCCCGAGTGCCTGGG CACCATCAACAATGA TGTGCCCAAGCACGT CCCGAGTGCCTGGGC
ACCATCAACAATGAG GTGCCCAAGCACGTG CCGAGTGCCTGGGCA CCATCAACAATGAGT
TGCCCAAGCACGTGT CGAGTGCCTGGGCAG CATCAACAATGAGTA GCCCAAGCACGTGTG
GAGTGCCTGGGCAGC ATCAACAATGAGTAC CCCAAGCACGTGTGG AGTGCCTGGGCAGCT
TCAACAATGAGTACA CCAAGCACGTGTGGG GTGCCTGGGCAGCTG CAACAATGAGTACAA
CAAGCACGTGTGGGA TGCCTGGGCAGCTGC AACAATGAGTACAAC AAGCACGTGTGGGAA
GCCTGGGCAGCTGCA ACAATGAGTACAACT AGCACGTGTGGGAAG CCTGGGCAGCTGCAG
CAATGAGTACAACTA GCACGTGTGGGAAGC CTGGGCAGCTGCAGC AATGAGTACAACTAC
CACGTGTGGGAAGCG TGGGCAGCTGCAGCG ATGAGTACAACTACC ACGTGTGGGAAGCGG
GGGCAGCTGCAGCGC
GGCAGCTGCAGCGCG CTATGCCGGTGTCTG GGCGCTGTGTGGACC GCAGCTGCAGCGCGC
TATGCCGGTGTCTGT GCGCTGTGTGGACCG CAGCTGCAGCGCGCC ATGCCGGTGTCTGTG
CGCTGTGTGGACCGT AGCTGCAGCGCGCCT TGCCGGTGTCTGTGT GCTGTGTGGACCGTG
GCTGCAGCGCGCCTG GCCGGTGTCTGTGTG CTGTGTGGACCGTGA CTGCAGCGCGCCTGA
CCGGTGTCTGTGTGC TGTGTGGACCGTGAC TGCAGCGCGCCTGAC CGGTGTCTGTGTGCC
GTGTGGACCGTGACT GCAGCGCGCCTGACA GGTGTCTGTGTGCCT TGTGGACCGTGACTT
CAGCGCGCCTGACAA GTGTCTGTGTGCCTG GTGGACCGTGACTTC AGCGCGCCTGACAAC
TGTCTGTGTGCCTGC TGGACCGTGACTTCT GCGCGCCTGACAACG GTCTGTGTGCCTGCC
GGACCGTGACTTCTG CGCGCCTGACAACGA TCTGTGTGCCTGCCT GACCGTGACTTCTGC
GCGCCTGACAACGAC CTGTGTGCCTGCCTG ACCGTGACTTCTGCG CGCCTGACAACGACA
TGTGTGCCTGCCTGC CCGTGACTTCTGCGC GCCTGACAACGACAC GTGTGCCTGCCTGCC
CGTGACTTCTGCGCC CCTGACAACGACACG TGTGCCTGCCTGCCC GTGACTTCTGCGCCA
CTGACAACGACACGG GTGCCTGCCTGCCCG TGACTTCTGCGCCAA TGACAACGACACGGC
TGCCTGCCTGCCCGC GACTTCTGCGCCAAC GACAACGACACGGCC GCCTGCCTGCCCGCC
ACTTCTGCGCCAACA ACAACGACACGGCCT CCTGCCTGCCCGCCC CTTCTGCGCCAACAT
CAACGACACGGCCTG CTGCCTGCCCGCCCA TTCTGCGCCAACATC AACGACACGGCCTGT
TGCCTGCCCGCCCAA TCTGCGCCAACATCC ACGACACGGCCTGTG GCCTGCCCGCCCAAC
CTGCGCCAACATCCT CGACACGGCCTGTGT CCTGCCCGCCCAACA TGCGCCAACATCCTC
GACACGGCCTGTGTA CTGCCCGCCCAACAC GCGCCAACATCCTCA ACACGGCCTGTGTAG
TGCCCGCCCAACACC CGCCAACATCCTCAG CACGGCCTGTGTAGC GCCCGCCCAACACCT
GCCAACATCCTCAGC ACGGCCTGTGTAGCT CCCGCCCAACACCTA CCAACATCCTCAGCG
CGGCCTGTGTAGCTT CCGCCCAACACCTAC CAACATCCTCAGCGC GGCCTGTGTAGCTTG
CGCCCAACACCTACA AACATCCTCAGCGCC GCCTGTGTAGCTTGC GCCCAACACCTACAG
ACATCCTCAGCGCCG CCTGTGTAGCTTGCC CCCAACACCTACAGG CATCCTCAGCGCCGA
CTGTGTAGCTTGCCG CCAACACCTACAGGT ATCCTCAGCGCCGAG TGTGTAGCTTGCCGC
CAACACCTACAGGTT TCCTCAGCGCCGAGA GTGTAGCTTGCCGCC AACACCTACAGGTTT
CCTCAGCGCCGAGAG TGTAGCTTGCCGCCA ACACCTACAGGTTTG CTCAGCGCCGAGAGC
GTAGCTTGCCGCCAC CACCTACAGGTTTGA TCAGCGCCGAGAGCA TAGCTTGCCGCCACT
ACCTACAGGTTTGAG CAGCGCCGAGAGCAG AGCTTGCCGCCACTA CCTACAGGTTTGAGG
AGCGCCGAGAGCAGC GCTTGCCGCCACTAC CTACAGGTTTGAGGG GCGCCGAGAGCAGCG
CTTGCCGCCACTACT TACAGGTTTGAGGGC CGCCGAGAGCAGCGA TTGCCGCCACTACTA
ACAGGTTTGAGGGCT GCCGAGAGCAGCGAC TGCCGCCACTACTAC CAGGTTTGAGGGCTG
CCGAGAGCAGCGACT GCCGCCACTACTACT AGGTTTGAGGGCTGG CGAGAGCAGCGACTC
CCGCCACTACTACTA GGTTTGAGGGCTGGC GAGAGCAGCGACTCC CGCCACTACTACTAT
GTTTGAGGGCTGGCG AGAGCAGCGACTCCG GCCACTACTACTATG TTTGAGGGCTGGCGC
GAGCAGCGACTCCGA CCACTACTACTATGC TTGAGGGCTGGCGCT AGCAGCGACTCCGAG
CACTACTACTATGCC TGAGGGCTGGCGCTG GCAGCGACTCCGAGG ACTACTACTATGCCG
GAGGGCTGGCGCTGT CAGCGACTCCGAGGG CTACTACTATGCCGG AGGGCTGGCGCTGTG
AGCGACTCCGAGGGG TACTACTATGCCGGT GGGCTGGCGCTGTGT GCGACTCCGAGGGGT
ACTACTATGCCGGTG GGCTGGCGCTGTGTG CGACTCCGAGGGGTT CTACTATGCCGGTGT
GCTGGCGCTGTGTGG GACTCCGAGGGGTTT TACTATGCCGGTGTC CTGGCGCTGTGTGGA
ACTCCGAGGGGTTTG ACTATGCCGGTGTCT TGGCGCTGTGTGGAC CTCCGAGGGGTTTGT
TCCGAGGGGTTTGTG CATCCGCAACGGCAG AGGTCTGTGAGGAAG CCGAGGGGTTTGTGA
ATCCGCAACGGCAGC GGTCTGTGAGGAAGA CGAGGGGTTTGTGAT TCCGCAACGGCAGCC
GTCTGTGAGGAAGAA GAGGGGTTTGTGATC CCGCAACGGCAGCCA TCTGTGAGGAAGAAA
AGGGGTTTGTGATCC CGCAACGGCAGCCAG CTGTGAGGAAGAAAA GGGGTTTGTGATCCA
GCAACGGCAGCCAGA TGTGAGGAAGAAAAG GGGTTTGTGATCCAC CAACGGCAGCCAGAG
GTGAGGAAGAAAAGA GGTTTGTGATCCACG AACGGCAGCCAGAGC TGAGGAAGAAAAGAA
GTTTGTGATCCACGA ACGGCAGCCAGAGCA GAGGAAGAAAAGAAA TTTGTGATCCACGAC
CGGCAGCCAGAGCAT AGGAAGAAAAGAAAA TTGTGATCCACGACG GGCAGCCAGAGCATG
GGAAGAAAAGAAAAC TGTGATCCACGACGG GCAGCCAGAGCATGT GAAGAAAAGAAAACA
GTGATCCACGACGGC CAGCCAGAGCATGTA AAGAAAAGAAAACAA TGATCCACGACGGCG
AGCCAGAGCATGTAC AGAAAAGAAAACAAA GATCCACGACGGCGA GCCAGAGCATGTACT
GAAAAGAAAACAAAG ATCCACGACGGCGAG CCAGAGCATGTACTG AAAAGAAAACAAAGA
TCCACGACGGCGAGT CAGAGCATGTACTGC AAAGAAAACAAAGAC CCACGACGGCGAGTG
AGAGCATGTACTGCA AAGAAAACAAAGACC CACGACGGCGAGTGC GAGCATGTACTGCAT
AGAAAACAAAGACCA ACGACGGCGAGTGCA AGCATGTACTGCATC GAAAACAAAGACCAT
CGACGGCGAGTGCAT GCATGTACTGCATCC AAAACAAAGACCATT GACGGCGAGTGCATG
CATGTACTGCATCCC AAACAAAGACCATTG ACGGCGAGTGCATGC ATGTACTGCATCCCT
AACAAAGACCATTGA CGGCGAGTGCATGCA TGTACTGCATCCCTT ACAAAGACCATTGAT
GGCGAGTGCATGCAG GTACTGCATCCCTTG CAAAGACCATTGATT GCGAGTGCATGCAGG
TACTGCATCCCTTGT AAAGACCATTGATTC CGAGTGCATGCAGGA ACTGCATCCCTTGTG
AAGACCATTGATTCT GAGTGCATGCAGGAG CTGCATCCCTTGTGA AGACCATTGATTCTG
AGTGCATGCAGGAGT TGCATCCCTTGTGAA GACCATTGATTCTGT GTGCATGCAGGAGTG
GCATCCCTTGTGAAG ACCATTGATTCTGTT TGCATGCAGGAGTGC CATCCCTTGTGAAGG
CCATTGATTCTGTTA GCATGCAGGAGTGCC ATCCCTTGTGAAGGT CATTGATTCTGTTAC
CATGCAGGAGTGCCC TCCCTTGTGAAGGTC ATTGATTCTGTTACT ATGCAGGAGTGCCCC
CCCTTGTGAAGGTCC TTGATTCTGTTACTT TGCAGGAGTGCCCCT CCTTGTGAAGGTCCT
TGATTCTGTTACTTC GCAGGAGTGCCCCTC CTTGTGAAGGTCCTT GATTCTGTTACTTCT
CAGGAGTGCCCCTCG TTGTGAAGGTCCTTG ATTCTGTTACTTCTG AGGAGTGCCCCTCGG
TGTGAAGGTCCTTGC TTCTGTTACTTCTGC GGAGTGCCCCTCGGG GTGAAGGTCCTTGCC
TCTGTTACTTCTGCT GAGTGCCCCTCGGGC TGAAGGTCCTTGCCC CTGTTACTTCTGCTC
AGTGCCCCTCGGGCT GAAGGTCCTTGCCCG TGTTACTTCTGCTCA GTGCCCCTCGGGCTT
AAGGTCCTTGCCCGA GTTACTTCTGCTCAG TGCCCCTCGGGCTTC AGGTCCTTGCCCGAA
TTACTTCTGCTCAGA GCCCCTCGGGCTTCA GGTCCTTGCCCGAAG TACTTCTGCTCAGAT
CCCCTCGGGCTTCAT GTCCTTGCCCGAAGG ACTTCTGCTCAGATG CCCTCGGGCTTCATC
TCCTTGCCCGAAGGT CTTCTGCTCAGATGC CCTCGGGCTTCATCC CCTTGCCCGAAGGTC
TTCTGCTCAGATGCT CTCGGGCTTCATCCG CTTGCCCGAAGGTCT TCTGCTCAGATGCTC
TCGGGCTTCATCCGC TTGCCCGAAGGTCTG CTGCTCAGATGCTCC CGGGCTTCATCCGCA
TGCCCGAAGGTCTGT TGCTCAGATGCTCCA GGGCTTCATCCGCAA GCCCGAAGGTCTGTG
GCTCAGATGCTCCAA GGCTTCATCCGCAAC CCCGAAGGTCTGTGA CTCAGATGCTCCAAG
GCTTCATCCGCAACG CCGAAGGTCTGTGAG TCAGATGCTCCAAGG CTTCATCCGCAACGG
CGAAGGTCTGTGAGG CAGATGCTCCAAGGA TTCATCCGCAACGGC GAAGGTCTGTGAGGA
AGATGCTCCAAGGAT TCATCCGCAACGGCA AAGGTCTGTGAGGAA GATGCTCCAAGGATG
ATGCTCCAAGGATGC GAATAACATTGCTTC CCTACGTGAAGATCC TGCTCCAAGGATGCA
AATAACATTGCTTCA CTACGTGAAGATCCG GCTCCAAGGATGCAC ATAACATTGCTTCAG
TACGTGAAGATCCGC CTCCAAGGATGCACC TAACATTGCTTCAGA ACGTGAAGATCCGCC
TCCAAGGATGCACCA AACATTGCTTCAGAG CGTGAAGATCCGCCA CCAAGGATGCACCAT
ACATTGCTTCAGAGC GTGAAGATCCGCCAT CAAGGATGCACCATC CATTGCTTCAGAGCT
TGAAGATCCGCCATT AAGGATGCACCATCT ATTGCTTCAGAGCTG GAAGATCCGCCATTC
AGGATGCACCATCTT TTGCTTCAGAGCTGG AAGATCCGCCATTCT GGATGCACCATCTTC
TGCTTCAGAGCTGGA AGATCCGCCATTCTC GATGCACCATCTTCA GCTTCAGAGCTGGAG
GATCCGCCATTCTCA ATGCACCATCTTCAA CTTCAGAGCTGGAGA ATCCGCCATTCTCAT
TGCACCATCTTCAAG TTCAGAGCTGGAGAA TCCGCCATTCTCATG GCACCATCTTCAAGG
TCAGAGCTGGAGAAC CCGCCATTCTCATGC CACCATCTTCAAGGG CAGAGCTGGAGAACT
CGCCATTCTCATGCC ACCATCTTCAAGGGC AGAGCTGGAGAACTT GCCATTCTCATGCCT
CCATCTTCAAGGGCA GAGCTGGAGAACTTC CCATTCTCATGCCTT CATCTTCAAGGGCAA
AGCTGGAGAACTTCA CATTCTCATGCCTTG ATCTTCAAGGGCAAT GCTGGAGAACTTCAT
ATTCTCATGCCTTGG TCTTCAAGGGCAATT CTGGAGAACTTCATG TTCTCATGCCTTGGT
CTTCAAGGGCAATTT TGGAGAACTTCATGG TCTCATGCCTTGGTC TTCAAGGGCAATTTG
GGAGAACTTCATGGG CTCATGCCTTGGTCT TCAAGGGCAATTTGC GAGAACTTCATGGGG
TCATGCCTTGGTCTC CAAGGGCAATTTGCT AGAACTTCATGGGGC CATGCCTTGGTCTCC
AAGGGCAATTTGCTC GAACTTCATGGGGCT ATGCCTTGGTCTCCT AGGGCAATTTGCTCA
AACTTCATGGGGCTC TGCCTTGGTCTCCTT GGGCAATTTGCTCAT ACTTCATGGGGCTCA
GCCTTGGTCTCCTTG GGCAATTTGCTCATT CTTCATGGGGCTCAT CCTTGGTCTCCTTGT
GCAATTTGCTCATTA TTCATGGGGCTCATC CTTGGTCTCCTTGTC CAATTTGCTCATTAA
TCATGGGGCTCATCG TTGGTCTCCTTGTCC AATTTGCTCATTAAC CATGGGGCTCATCGA
TGGTCTCCTTGTCCT ATTTGCTCATTAACA ATGGGGCTCATCGAG GGTCTCCTTGTCCTT
TTTGCTCATTAACAT TGGGGCTCATCGAGG GTCTCCTTGTCCTTC TTGCTCATTAACATC
GGGGCTCATCGAGGT TCTCCTTGTCCTTCC TGCTCATTAACATCC GGGCTCATCGAGGTG
CTCCTTGTCCTTCCT GCTCATTAACATCCG GGCTCATCGAGGTGG TCCTTGTCCTTCCTA
CTCATTAACATCCGA GCTCATCGAGGTGGT CCTTGTCCTTCCTAA TCATTAACATCCGAC
CTCATCGAGGTGGTG CTTGTCCTTCCTAAA CATTAACATCCGACG TCATCGAGGTGGTGA
TTGTCCTTCCTAAAA ATTAACATCCGACGG CATCGAGGTGGTGAC TGTCCTTCCTAAAAA
TTAACATCCGACGGG ATCGAGGTGGTGACG GTCCTTCCTAAAAAA TAACATCCGACGGGG
TCGAGGTGGTGACGG TCCTTCCTAAAAAAC AACATCCGACGGGGG CGAGGTGGTGACGGG
CCTTCCTAAAAAACC ACATCCGACGGGGGA GAGGTGGTGACGGGC CTTCCTAAAAAACCT
CATCCGACGGGGGAA AGGTGGTGACGGGCT TTCCTAAAAAACCTT ATCCGACGGGGGAAT
GGTGGTGACGGGCTA TCCTAAAAAACCTTC TCCGACGGGGGAATA GTGGTGACGGGCTAC
CCTAAAAAACCTTCG CCGACGGGGGAATAA TGGTGACGGGCTACG CTAAAAAACCTTCGC
CGACGGGGGAATAAC GGTGACGGGCTACGT TAAAAAACCTTCGCC GACGGGGGAATAACA
GTGACGGGCTACGTG AAAAAACCTTCGCCT ACGGGGGAATAACAT TGACGGGCTACGTGA
AAAAACCTTCGCCTC CGGGGGAATAACATT GACGGGCTACGTGAA AAAACCTTCGCCTCA
GGGGGAATAACATTG ACGGGCTACGTGAAG AAACCTTCGCCTCAT GGGGAATAACATTGC
CGGGCTACGTGAAGA AACCTTCGCCTCATC GGGAATAACATTGCT GGGCTACGTGAAGAT
ACCTTCGCCTCATCC GGAATAACATTGCTT GGCTACGTGAAGATC CCTTCGCCTCATCCT
CTTCGCCTCATCCTA CGACAACCAGAACTT AAGCAGGGAAAATGT TTCGCCTCATCCTAG
GACAACCAGAACTTG AGCAGGGAAAATGTA TCGCCTCATCCTAGG ACAACCAGAACTTGC
GCAGGGAAAATGTAC CGCCTCATCCTAGGA CAACCAGAACTTGCA CAGGGAAAATGTACT
GCCTCATCCTAGGAG AACCAGAACTTGCAG AGGGAAAATGTACTT CCTCATCCTAGGAGA
ACCAGAACTTGCAGC GGGAAAATGTACTTT CTCATCCTAGGAGAG CCAGAACTTGCAGCA
GGAAAATGTACTTTG TCATCCTAGGAGAGG CAGAACTTGCAGCAA GAAAATGTACTTTGC
CATCCTAGGAGAGGA AGAACTTGCAGCAAC AAAATGTACTTTGCT ATCCTAGGAGAGGAG
GAACTTGCAGCAACT AAATGTACTTTGCTT TCCTAGGAGAGGAGC AACTTGCAGCAACTG
AATGTACTTTGCTTT CCTAGGAGAGGAGCA ACTTGCAGCAACTGT ATGTACTTTGCTTTC
CTAGGAGAGGAGCAG CTTGCAGCAACTGTG TGTACTTTGCTTTCA TAGGAGAGGAGCAGC
TTGCAGCAACTGTGG GTACTTTGCTTTCAA AGGAGAGGAGCAGCT TGCAGCAACTGTGGG
TACTTTGCTTTCAAT GGAGAGGAGCAGCTA GCAGCAACTGTGGGA ACTTTGCTTTCAATC
GAGAGGAGCAGCTAG CAGCAACTGTGGGAC CTTTGCTTTCAATCC AGAGGAGCAGCTAGA
AGCAACTGTGGGACT TTTGCTTTCAATCCC GAGGAGCAGCTAGAA GCAACTGTGGGACTG
TTGCTTTCAATCCCA AGGAGCAGCTAGAAG CAACTGTGGGACTGG TGCTTTCAATCCCAA
GGAGCAGCTAGAAGG AACTGTGGGACTGGG GCTTTCAATCCCAAA GAGCAGCTAGAAGGG
ACTGTGGGACTGGGA CTTTCAATCCCAAAT AGCAGCTAGAAGGGA CTGTGGGACTGGGAC
TTTCAATCCCAAATT GCAGCTAGAAGGGAA TGTGGGACTGGGACC TTCAATCCCAAATTA
CAGCTAGAAGGGAAT GTGGGACTGGGACCA TCAATCCCAAATTAT AGCTAGAAGGGAATT
TGGGACTGGGACCAC CAATCCCAAATTATG GCTAGAAGGGAATTA GGGACTGGGACCACC
AATCCCAAATTATGT CTAGAAGGGAATTAC GGACTGGGACCACCG ATCCCAAATTATGTG
TAGAAGGGAATTACT GACTGGGACCACCGC TCCCAAATTATGTGT AGAAGGGAATTACTC
ACTGGGACCACCGCA CCCAAATTATGTGTT GAAGGGAATTACTCC CTGGGACCACCGCAA
CCAAATTATGTGTTT AAGGGAATTACTCCT TGGGACCACCGCAAC CAAATTATGTGTTTC
AGGGAATTACTCCTT GGGACCACCGCAACC AAATTATGTGTTTCC GGGAATTACTCCTTC
GGACCACCGCAACCT AATTATGTGTTTCCG GGAATTACTCCTTCT GACCACCGCAACCTG
ATTATGTGTTTCCGA GAATTACTCCTTCTA ACCACCGCAACCTGA TTATGTGTTTCCGAA
AATTACTCCTTCTAC CCACCGCAACCTGAC TATGTGTTTCCGAAA ATTACTCCTTCTACG
CACCGCAACCTGACC ATGTGTTTCCGAAAT TTACTCCTTCTACGT ACCGCAACCTGACCA
TGTGTTTCCGAAATT TACTCCTTCTACGTC CCGCAACCTGACCAT GTGTTTCCGAAATTT
ACTCCTTCTACGTCC CGCAACCTGACCATC TGTTTCCGAAATTTA CTCCTTCTACGTCCT
GCAACCTGACCATCA GTTTCCGAAATTTAC TCCTTCTACGTCCTC CAACCTGACCATCAA
TTTCCGAAATTTACC CCTTCTACGTCCTCG AACCTGACCATCAAA TTCCGAAATTTACCG
CTTCTACGTCCTCGA ACCTGACCATCAAAG TCCGAAATTTACCGC TTCTACGTCCTCGAC
CCTGACCATCAAAGC CCGAAATTTACCGCA TCTACGTCCTCGACA CTGACCATCAAAGCA
CGAAATTTACCGCAT CTACGTCCTCGACAA TGACCATCAAAGCAG GAAATTTACCGCATG
TACGTCCTCGACAAC GACCATCAAAGCAGG AAATTTACCGCATGG ACGTCCTCGACAACC
ACCATCAAAGCAGGG AATTTACCGCATGGA CGTCCTCGACAACCA CCATCAAAGCAGGGA
ATTTACCGCATGGAG GTCCTCGACAACCAG CATCAAAGCAGGGAA TTTACCGCATGGAGG
TCCTCGACAACCAGA ATCAAAGCAGGGAAA TTACCGCATGGAGGA CCTCGACAACCAGAA
TCAAAGCAGGGAAAA TACCGCATGGAGGAA CTCGACAACCAGAAC CAAAGCAGGGAAAAT
ACCGCATGGAGGAAG TCGACAACCAGAACT AAAGCAGGGAAAATG CCGCATGGAGGAAGT
CGCATGGAGGAAGTG CAGGAACAACGGGGA CCACCACGTCGAAGA GCATGGAGGAAGTGA
AGGAACAACGGGGAG CACCACGTCGAAGAA CATGGAGGAAGTGAC GGAACAACGGGGAGA
ACCACGTCGAAGAAT ATGGAGGAAGTGACG GAACAACGGGGAGAG CCACGTCGAAGAATC
TGGAGGAAGTGACGG AACAACGGGGAGAGA CACGTCGAAGAATCG GGAGGAAGTGACGGG
ACAACGGGGAGAGAG ACGTCGAAGAATCGC GAGGAAGTGACGGGG CAACGGGGAGAGAGC
CGTCGAAGAATCGCA AGGAAGTGACGGGGA AACGGGGAGAGAGCC GTCGAAGAATCGCAT
GGAAGTGACGGGGAC ACGGGGAGAGAGCCT TCGAAGAATCGCATC GAAGTGACGGGGACT
CGGGGAGAGAGCCTC CGAAGAATCGCATCA AAGTGACGGGGACTA GGGGAGAGAGCCTCC
GAAGAATCGCATCAT AGTGACGGGGACTAA GGGAGAGAGCCTCCT AAGAATCGCATCATC
GTGACGGGGACTAAA GGAGAGAGCCTCCTG AGAATCGCATCATCA TGACGGGGACTAAAG
GAGAGAGCCTCCTGT GAATCGCATCATCAT GACGGGGACTAAAGG AGAGAGCCTCCTGTG
AATCGCATCATCATA ACGGGGACTAAAGGG GAGAGCCTCCTGTGA ATCGCATCATCATAA
CGGGGACTAAAGGGC AGAGCCTCCTGTGAA TCGCATCATCATAAC GGGGACTAAAGGGCG
GAGCCTCCTGTGAAA CGCATCATCATAACC GGGACTAAAGGGCGC AGCCTCCTGTGAAAG
GCATCATCATAACCT GGACTAAAGGGCGCC GCCTCCTGTGAAAGT CATCATCATAACCTG
GACTAAAGGGCGCCA CCTCCTGTGAAAGTG ATCATCATAACCTGG ACTAAAGGGCGCCAA
CTCCTGTGAAAGTGA TCATCATAACCTGGC CTAAAGGGCGCCAAA TCCTGTGAAAGTGAC
CATCATAACCTGGCA TAAAGGGCGCCAAAG CCTGTGAAAGTGACG ATCATAACCTGGCAC
AAAGGGCGCCAAAGC CTGTGAAAGTGACGT TCATAACCTGGCACC AAGGGCGCCAAAGCA
TGTGAAAGTGACGTC CATAACCTGGCACCG AGGGCGCCAAAGCAA GTGAAAGTGACGTCC
ATAACCTGGCACCGG
GGGCGCCAAAGCAAA TGAAAGTGACGTCCT TAACCTGGCACCGGT GGCGCCAAAGCAAAG
GAAAGTGACGTCCTG AACCTGGCACCGGTA GCGCCAAAGCAAAGG AAAGTGACGTCCTGC
ACCTGGCACCGGTAC CGCCAAAGCAAAGGG AAGTGACGTCCTGCA CCTGGCACCGGTACC
GCCAAAGCAAAGGGG AGTGACGTCCTGCAT CTGGCACCGGTACCG CCAAAGCAAAGGGGA
GTGACGTCCTGCATT TGGCACCGGTACCGG CAAAGCAAAGGGGAC TGACGTCCTGCATTT
GGCACCGGTACCGGC AAAGCAAAGGGGACA GACGTCCTGCATTTC GCACCGGTACCGGCC
AAGCAAAGGGGACAT ACGTCCTGCATTTCA CACCGGTACCGGCCC AGCAAAGGGGACATA
CGTCCTGCATTTCAC ACCGGTACCGGCCCC GCAAAGGGGACATAA GTCCTGCATTTCACC
CCGGTACCGGCCCCC CAAAGGGGACATAAA TCCTGCATTTCACCT CGGTACCGGCCCCCT
AAAGGGGACATAAAC CCTGCATTTCACCTC GGTACCGGCCCCCTG AAGGGGACATAAACA
CTGCATTTCACCTCC GTACCGGCCCCCTGA AGGGGACATAAACAC TGCATTTCACCTCCA
TACCGGCCCCCTGAC GGGGACATAAACACC GCATTTCACCTCCAC ACCGGCCCCCTGACT
GGGACATAAACACCA CATTTCACCTCCACC CCGGCCCCCTGACTA GGACATAAACACCAG
ATTTCACCTCCACCA CGGCCCCCTGACTAC GACATAAACACCAGG TTTCACCTCCACCAC
GGCCCCCTGACTACA ACATAAACACCAGGA TTCACCTCCACCACC GCCCCCTGACTACAG
CATAAACACCAGGAA TCACCTCCACCACCA CCCCCTGACTACAGG ATAAACACCAGGAAC
CACCTCCACCACCAC CCCCTGACTACAGGG TAAACACCAGGAACA ACCTCCACCACCACG
CCCTGACTACAGGGA AAACACCAGGAACAA CCTCCACCACCACGT CCTGACTACAGGGAT
AACACCAGGAACAAC CTCCACCACCACGTC CTGACTACAGGGATC ACACCAGGAACAACG
TCCACCACCACGTCG TGACTACAGGGATCT CACCAGGAACAACGG CCACCACCACGTCGA
GACTACAGGGATCTC ACCAGGAACAACGGG CACCACCACGTCGAA ACTACAGGGATCTCA
CCAGGAACAACGGGG ACCACCACGTCGAAG CTACAGGGATCTCAT TACAGGGATCTCATC
CACAGAGTATGATGG TGGACCTCCCGCCCA ACAGGGATCTCATCA ACAGAGTATGATGGG
GGACCTCCCGCCCAA CAGGGATCTCATCAG CAGAGTATGATGGGC GACCTCCCGCCCAAC
AGGGATCTCATCAGC AGAGTATGATGGGCA ACCTCCCGCCCAACA GGGATCTCATCAGCT
GAGTATGATGGGCAG CCTCCCGCCCAACAA GGATCTCATCAGCTT AGTATGATGGGCAGG
CTCCCGCCCAACAAG GATCTCATCAGCTTC GTATGATGGGCAGGA TCCCGCCCAACAAGG
ATCTCATCAGCTTCA TATGATGGGCAGGAT CCCGCCCAACAAGGA TCTCATCAGCTTCAC
ATGATGGGCAGGATG CCGCCCAACAAGGAC CTCATCAGCTTCACC TGATGGGCAGGATGC
CGCCCAACAAGGACG TCATCAGCTTCACCG GATGGGCAGGATGCC GCCCAACAAGGACGT
CATCAGCTTCACCGT ATGGGCAGGATGCCT CCCAACAAGGACGTG ATCAGCTTCACCGTT
TGGGCAGGATGCCTG CCAACAAGGACGTGG TCAGCTTCACCGTTT GGGCAGGATGCCTGC
CAACAAGGACGTGGA CAGCTTCACCGTTTA GGCAGGATGCCTGCG AACAAGGACGTGGAG
AGCTTCACCGTTTAC GCAGGATGCCTGCGG ACAAGGACGTGGAGC GCTTCACCGTTTACT
CAGGATGCCTGCGGC CAAGGACGTGGAGCC CTTCACCGTTTACTA AGGATGCCTGCGGCT
AAGGACGTGGAGCCC TTCACCGTTTACTAC GGATGCCTGCGGCTC AGGACGTGGAGCCCG
TCACCGTTTACTACA GATGCCTGCGGCTCC GGACGTGGAGCCCGG CACCGTTTACTACAA
ATGCCTGCGGCTCCA GACGTGGAGCCCGGC ACCGTTTACTACAAG TGCCTGCGGCTCCAA
ACGTGGAGCCCGGCA CCGTTTACTACAAGG GCCTGCGGCTCCAAC CGTGGAGCCCGGCAT
CGTTTACTACAAGGA CCTGCGGCTCCAACA GTGGAGCCCGGCATC GTTTACTACAAGGAA
CTGCGGCTCCAACAG TGGAGCCCGGCATCT TTTACTACAAGGAAG TGCGGCTCCAACAGC
GGAGCCCGGCATCTT TTACTACAAGGAAGC GCGGCTCCAACAGCT GAGCCCGGCATCTTA
TACTACAAGGAAGCA CGGCTCCAACAGCTG AGCCCGGCATCTTAC ACTACAAGGAAGCAC
GGCTCCAACAGCTGG GCCCGGCATCTTACT CTACAAGGAAGCACC GCTCCAACAGCTGGA
CCCGGCATCTTACTA TACAAGGAAGCACCC CTCCAACAGCTGGAA CCGGCATCTTACTAC
ACTAGGAAGCACCCT TCCAACAGCTGGAAC CGGCATCTTACTACA CAAGGAAGCACCCTT
CCAACAGCTGGAACA GGCATCTTACTACAT AAGGAAGCACCCTTT CAACAGCTGGAACAT
GCATCTTACTACATG AGGAAGCACCCTTTA AACAGCTGGAACATG CATCTTACTACATGG
GGAAGCACCCTTTAA ACAGCTGGAACATGG ATCTTACTACATGGG GAAGCACCCTTTAAG
CAGCTGGAACATGGT TCTTACTACATGGGC AAGCACCCTTTAAGA AGCTGGAACATGGTG
CTTACTACATGGGCT AGCACCCTTTAAGAA GCTGGAACATGGTGG TTACTACATGGGCTG
GCACCCTTTAAGAAT CTGGAACATGGTGGA TACTACATGGGCTGA CACCCTTTAAGAATG
TGGAACATGGTGGAC ACTACATGGGCTGAA ACCCTTTAAGAATGT GGAACATGGTGGACG
CTACATGGGCTGAAG CCCTTTAAGAATGTC GAACATGGTGGACGT TACATGGGCTGAAGC
CCTTTAAGAATGTCA AACATGGTGGACGTG ACATGGGCTGAAGCC CTTTAAGAATGTCAC
ACATGGTGGACGTGG CATGGGCTGAAGCCC TTTAAGAATGTCACA CATGGTGGACGTGGA
ATGGGCTGAAGCCCT TTAAGAATGTCACAG ATGGTGGACGTGGAC TGGGCTGAAGCCCTG
TAAGAATGTCACAGA TGGTGGACGTGGACC GGGCTGAAGCCCTGG AAGAATGTCACAGAG
GGTGGACGTGGACCT GGCTGAAGCCCTGGA AGAATGTCACAGAGT GTGGACGTGGACCTC
GCTGAAGCCCTGGAC GAATGTCACAGAGTA TGGACGTGGACCTCC CTGAAGCCCTGGACT
AATGTCACAGAGTAT GGACGTGGACCTCCC TGAAGCCCTGGACTC ATGTCACAGAGTATG
GACGTGGACCTCCCG GAAGCCCTGGACTCA TGTCACAGAGTATGA ACGTGGACCTCCCGC
AAGCCCTGGACTCAG GTCACAGAGTATGAT CGTGGACCTCCCGCC AGCCCTGGACTCAGT
TCACAGAGTATGATG GTGGACCTCCCGCCC GCCCTGGACTCAGTA CCCTGGACTCAGTAC
CGACCATATCCGTGG TTCCTTCCATTCCCT CCTGGACTCAGTACG GACCATATCCGTGGG
TCCTTCCATTCCCTT CTGGACTCAGTACGC ACCATATCCGTGGGG CCTTCCATTCCCTTG
TGGACTCAGTACGCC CCATATCCGTGGGGC CTTCCATTCCCTTGG GGACTCAGTACGCCG
CATATCCGTGGGGCC TTCCATTCCCTTGGA GACTCAGTACGCCGT ATATCCGTGGGGCCA
TCCATTCCCTTGGAC ACTCAGTACGCCGTT TATCCGTGGGGCCAA CCATTCCCTTGGACG
CTCAGTACGCCGTTT ATCCGTGGGGCCAAG CATTCCCTTGGACGT TCAGTACGCCGTTTA
TCCGTGGGGCCAAGA ATTCCCTTGGACGTT CAGTACGCCGTTTAC CCGTGGGGCCAAGAG
TTCCCTTGGACGTTC AGTACGCCGTTTACG CGTGGGGCCAAGAGT TCCCTTGGACGTTCT
GTACGCCGTTTACGT GTGGGGCCAAGAGTG CCCTTGGACGTTCTT TACGCCGTTTACGTC
TGGGGCCAAGAGTGA CCTTGGACGTTCTTT ACGCCGTTTACGTCA GGGGCCAAGAGTGAG
CTTGGACGTTCTTTC CGCCGTTTACGTCAA GGGCCAAGAGTGAGA TTGGACGTTCTTTCA
GCCGTTTACGTCAAG GGCCAAGAGTGAGAT TGGACGTTCTTTCAG CCGTTTACGTCAAGG
GCCAAGAGTGAGATC GGACGTTCTTTCAGC CGTTTACGTCAAGGC CCAAGAGTGAGATCT
GACGTTCTTTCAGCA GTTTACGTCAAGGCT CAAGAGTGAGATCTT ACGTTCTTTCAGCAT
TTTACGTCAAGGCTG AAGAGTGAGATCTTG CGTTCTTTCAGCATC TTACGTCAAGGCTGT
AGAGTGAGATCTTGT GTTCTTTCAGCATCG TACGTCAAGGCTGTG GAGTGAGATCTTGTA
TTCTTTCAGCATCGA ACGTCAAGGCTGTGA AGTGAGATCTTGTAC TCTTTCAGCATCGAA
CGTCAAGGCTGTGAC GTGAGATCTTGTACA CTTTCAGCATCGAAC GTCAAGGCTGTGACC
TGAGATCTTGTACAT TTTCAGCATCGAACT TCAAGGCTGTGACCC GAGATCTTGTACATT
TTCAGCATCGAACTC CAAGGCTGTGACCCT AGATCTTGTACATTC TCAGCATCGAACTCC
AAGGCTGTGACCCTC GATCTTGTACATTCG CAGCATCGAACTCCT AGGCTGTGACCCTCA
ATCTTGTACATTCGC AGCATCGAACTCCTC GGCTGTGACCCTCAC TCTTGTACATTCGCA
GCATCGAACTCCTCT GCTGTGACCCTCACC CTTGTACATTCGCAC CATCGAACTCCTCTT
CTGTGACCCTCACCA TTGTACATTCGCACC ATCGAACTCCTCTTC TGTGACCCTCACCAT
TGTACATTCGCACCA TCGAACTCCTCTTCT GTGACCCTCACCATG GTACATTCGCACCAA
CGAACTCCTCTTCTC TGACCCTCACCATGG TACATTCGCACCAAT GAACTCCTCTTCTCA
GACCCTCACCATGGT ACATTCGCACCAATG AACTCCTCTTCTCAG ACCCTCACCATGGTG
CATTCGCACCAATGC ACTCCTCTTCTCAGT CCCTCACCATGGTGG ATTCGCACCAATGCT
CTCCTCTTCTCAGTT CCTCACCATGGTGGA TTCGCACCAATGCTT TCCTCTTCTCAGTTA
CTCACCATGGTGGAG TCGCACCAATGCTTC CCTCTTCTCAGTTAA TCACCATGGTGGAGA
CGCACCAATGCTTCA CTCTTCTCAGTTAAT CACCATGGTGGAGAA GCACCAATGCTTCAG
TCTTCTCAGTTAATC ACCATGGTGGAGAAC CACCAATGCTTCAGT CTTCTCAGTTAATCG
CCATGGTGGAGAACG ACCAATGCTTCAGTT TTCTCAGTTAATCGT CATGGTGGAGAACGA
CCAATGCTTCAGTTC TCTCAGTTAATCGTG ATGGTGGAGAACGAC CAATGCTTCAGTTCC
CTCAGTTAATCGTGA TGGTGGAGAACGACC AATGCTTCAGTTCCT TCAGTTAATCGTGAA
GGTGGAGAACGACCA ATGCTTCAGTTCCTT CAGTTAATCGTGAAG GTGGAGAACGACCAT
TGCTTCAGTTCCTTC AGTTAATCGTGAAGT TGGAGAACGACCATA GCTTCAGTTCCTTCC
GTTAATCGTGAAGTG GGAGAACGACCATAT CTTCAGTTCCTTCCA TTAATCGTGAAGTGG
GAGAACGACCATATC TTCAGTTCCTTCCAT TAATCGTGAAGTGGA AGAACGACCATATCC
TCAGTTCCTTCCATT AATCGTGAAGTGGAA GAACGACCATATCCG CAGTTCCTTCCATTC
ATCGTGAAGTGGAAC AACGACCATATCCGT AGTTCCTTCCATTCC TCGTGAAGTGGAACC
ACGACCATATCCGTG GTTCCTTCCATTCCC CGTGAAGTGGAACCC GTGAAGTGGAACCCT
CTGGCAGCGGCAGCC ACAAAATCCCCATCA TGAAGTGGAACCCTC TGGCAGCGGCAGCCT
CAAAATCCCCATCAG GAAGTGGAACCCTCC GGCAGCGGCAGCCTC AAAATCCCCATCAGG
AAGTGGAACCCTCCC GCAGCGGCAGCCTCA AAATCCCCATCAGGA AGTGGAACCCTCCCT
CAGCGGCAGCCTCAG AATCCCCATCAGGAA GTGGAACCCTCCCTC AGCGGCAGCCTCAGG
ATCCCCATCAGGAAG TGGAACCCTCCCTCT GCGGCAGCCTCAGGA TCCCCATCAGGAAGT
GGAACCCTCCCTCTC CGGCAGCCTCAGGAC CCCCATCAGGAAGTA GAACCCTCCCTCTCT
GGCAGCCTCAGGACG CCCATCAGGAAGTAT AACCCTCCCTCTCTG GCAGCCTCAGGACGG
CCATCAGGAAGTATG ACCCTCCCTCTCTGC CAGCCTCAGGACGGC CATCAGGAAGTATGC
CCCTCCCTCTCTGCC AGCCTCAGGACGGCT ATCAGGAAGTATGCC CCTCCCTCTCTGCCC
GCCTCAGGACGGCTA TCAGGAAGTATGCCG CTCCCTCTCTGCCCA CCTCAGGACGGCTAC
CAGGAAGTATGCCGA TCCCTCTCTGCCCAA CTCAGGACGGCTACC AGGAAGTATGCCGAC
CCCTCTCTGCCCAAC TCAGGACGGCTACCT GGAAGTATGCCGACG CCTCTCTGCCCAACG
CAGGACGGCTACCTT GAAGTATGCCGACGG CTCTCTGCCCAACGG AGGACGGCTACCTTT
AAGTATGCCGACGGC TCTCTGCCCAACGGC GGACGGCTACCTTTA AGTATGCCGACGGCA
CTCTGCCCAACGGCA GACGGCTACCTTTAC GTATGCCGACGGCAC TCTGCCCAACGGCAA
ACGGCTACCTTTACC TATGCCGACGGCACC CTGCCCAACGGCAAC CGGCTACCTTTACCG
ATGCCGACGGCACCA TGCCCAACGGCAACC GGCTACCTTTACCGG TGCCGACGGCACCAT
GCCCAACGGCAACCT GCTACCTTTACCGGC GCCGACGGCACCATC CCCAACGGCAACCTG
CTACCTTTACCGGCA CCGACGGCACCATCG CCAACGGCAACCTGA TACCTTTACCGGCAC
CGACGGCACCATCGA CAACGGCAACCTGAG ACCTTTACCGGCACA GACGGCACCATCGAC
AACGGCAACCTGAGT CCTTTACCGGCACAA ACGGCACCATCGACA ACGGCAACCTGAGTT
CTTTACCGGCACAAT CGGCACCATCGACAT CGGCAACCTGAGTTA TTTACCGGCACAATT
GGCACCATCGACATT GGCAACCTGAGTTAC TTACCGGCACAATTA GCACCATCGACATTG
GCAACCTGAGTTACT TACCGGCACAATTAC CACCATCGACATTGA CAACCTGAGTTACTA
ACCGGCACAATTACT ACCATCGACATTGAG AACCTGAGTTACTAC CCGGCACAATTACTG
CCATCGACATTGAGG ACCTGAGTTACTACA CGGCACAATTACTGC CATCGACATTGAGGA
CCTGAGTTACTACAT GGCACAATTACTGCT ATCGACATTGAGGAG CTGAGTTACTACATT
GCACAATTACTGCTC TCGACATTGAGGAGG TGAGTTACTACATTG CACAATTACTGCTCC
CGACATTGAGGAGGT GAGTTACTACATTGT ACAATTACTGCTCCA GACATTGAGGAGGTC
AGTTACTACATTGTG CAATTACTGCTCCAA ACATTGAGGAGGTCA GTTACTACATTGTGC
AATTACTGCTCCAAA CATTGAGGAGGTCAC TTACTACATTGTGCG ATTACTGCTCCAAAG
ATTGAGGAGGTCACA TACTACATTGTGCGC TTACTGCTCCAAAGA TTGAGGAGGTCACAG
ACTACATTGTGCGCT TACTGCTCCAAAGAC TGAGGAGGTCACAGA CTACATTGTGCGCTG
ACTGCTCCAAAGACA GAGGAGGTCACAGAG TACATTGTGCGCTGG CTGCTCCAAAGACAA
AGGAGGTCACAGAGA ACATTGTGCGCTGGC TGCTCCAAAGACAAA GGAGGTCACAGAGAA
CATTGTGCGCTGGCA GCTCCAAAGACAAAA GAGGTCACAGAGAAC ATTGTGCGCTGGCAG
CTCCAAAGACAAAAT AGGTCACAGAGAACC TTGTGCGCTGGCAGC TCCAAAGACAAAATC
GGTCACAGAGAACCC TGTGCGCTGGCAGCG CCAAAGACAAAATCC GTCACAGAGAACCCC
GTGCGCTGGCAGCGG CAAAGACAAAATCCC TCACAGAGAACCCCA TGCGCTGGCAGCGGC
AAAGACAAAATCCCC CACAGAGAACCCCAA GCGCTGGCAGCGGCA AAGACAAAATCCCCA
ACAGAGAACCCCAAG CGCTGGCAGCGGCAG AGACAAAATCCCCAT CAGAGAACCCCAAGA
GCTGGCAGCGGCAGC GACAAAATCCCCATC AGAGAACCCCAAGAC GAGAACCCCAAGACT
CAAAACTGAAGCCGA TTGAGAATTTCCTGC AGAACCCCAAGACTG AAAACTGAAGCCGAG
TGAGAATTTCCTGCA GAACCCCAAGACTGA AAACTGAAGCCGAGA GAGAATTTCCTGCAC
AACCCCAAGACTGAG AACTGAAGCCGAGAA AGAATTTCCTGCACA ACCCCAAGACTGAGG
ACTGAAGCCGAGAAG GAATTTCCTGCACAA CCCCAAGACTGAGGT CTGAAGCCGAGAAGC
AATTTCCTGCACAAC CCCAAGACTGAGGTG TGAAGCCGAGAAGCA ATTTCCTGCACAACT
CCAAGACTGAGGTGT GAAGCCGAGAAGCAG TTTCCTGCACAACTC CAAGACTGAGGTGTG
AAGCCGAGAAGCAGG TTCCTGCACAACTCC AAGACTGAGGTGTGT AGCCGAGAAGCAGGC
TCCTGCACAACTCCA AGACTGAGGTGTGTG GCCGAGAAGCAGGCC CCTGCACAACTCCAT
GACTGAGGTGTGTGG CCGAGAAGCAGGCCG CTGCACAACTCCATC ACTGAGGTGTGTGGT
CGAGAAGCAGGCCGA TGCACAACTCCATCT CTGAGGTGTGTGGTG GAGAAGCAGGCCGAG
GCACAACTCCATCTT TGAGGTGTGTGGTGG AGAAGCAGGCCGAGA CACAACTCCATCTTC
GAGGTGTGTGGTGGG GAAGCAGGCCGAGAA ACAACTCCATCTTCG AGGTGTGTGGTGGGG
AAGCAGGCCGAGAAG CAACTCCATCTTCGT GGTGTGTGGTGGGGA AGCAGGCCGAGAAGG
AACTCCATCTTCGTG GTGTGTGGTGGGGAG GCAGGCCGAGAAGGA ACTCCATCTTCGTGC
TGTGTGGTGGGGAGA CAGGCCGAGAAGGAG CTCCATCTTCGTGCC GTGTGGTGGGGAGAA
AGGCCGAGAAGGAGG TCCATCTTCGTGCCC TGTGGTGGGGAGAAA GGCCGAGAAGGAGGA
CCATCTTCGTGCCCA GTGGTGGGGAGAAAG GCCGAGAAGGAGGAG CATCTTCGTGCCCAG
TGGTGGGGAGAAAGG CCGAGAAGGAGGAGG ATCTTCGTGCCCAGA GGTGGGGAGAAAGGG
CGAGAAGGAGGAGGC TCTTCGTGCCCAGAC GTGGGGAGAAAGGGC GAGAAGGAGGAGGCT
CTTCGTGCCCAGACC TGGGGAGAAAGGGCC AGAAGGAGGAGGCTG TTCGTGCCCAGACCT
GGGGAGAAAGGGCCT GAAGGAGGAGGCTGA TCGTGCCCAGACCTG GGGAGAAAGGGCCTT
AAGGAGGAGGCTGAA CGTGCCCAGACCTGA GGAGAAAGGGCCTTG AGGAGGAGGCTGAAT
GTGCCCAGACCTGAA GAGAAAGGGCCTTGC GGAGGAGGCTGAATA TGCCCAGACCTGAAA
AGAAAGGGCCTTGCT GAGGAGGCTGAATAC GCCCAGACCTGAAAG GAAAGGGCCTTGCTG
AGGAGGCTGAATACC CCCAGACCTGAAAGG AAAGGGCCTTGCTGC GGAGGCTGAATACCG
CCAGACCTGAAAGGA AAGGGCCTTGCTGCG GAGGCTGAATACCGC CAGACCTGAAAGGAA
AGGGCCTTGCTGCGC AGGCTGAATACCGCA AGACCTGAAAGGAAG GGGCCTTGCTGCGCC
GGCTGAATACCGCAA GACCTGAAAGGAAGC GGCCTTGCTGCGCCT GCTGAATACCGCAAA
ACCTGAAAGGAAGCG GCCTTGCTGCGCCTG CTGAATACCGCAAAG CCTGAAAGGAAGCGG
CCTTGCTGCGCCTGC TGAATACCGCAAAGT CTGAAAGGAAGCGGA CTTGCTGCGCCTGCC
GAATACCGCAAAGTC TGAAAGGAAGCGGAG TTGCTGCGCCTGCCC AATACCGCAAAGTCT
GAAAGGAAGCGGAGA TGCTGCGCCTGCCCC ATACCGCAAAGTCTT AAAGGAAGCGGAGAG
GCTGCGCCTGCCCCA TACCGCAAAGTCTTT AAGGAAGCGGAGAGA CTGCGCCTGCCCCAA
ACCGCAAAGTCTTTG AGGAAGCGGAGAGAT TGCGCCTGCCCCAAA CCGCAAAGTCTTTGA
GGAAGCGGAGAGATG GCGCCTGCCCCAAAA CGCAAAGTCTTTGAG GAAGCGGAGAGATGT
CGCCTGCCCCAAAAC GCAAAGTCTTTGAGA AAGCGGAGAGATGTC GCCTGCCCCAAAACT
CAAAGTCTTTGAGAA AGCGGAGAGATGTCA CCTGCCCCAAAACTG AAAGTCTTTGAGAAT
GCGGAGAGATGTCAT CTGCCCCAAAACTGA AAGTCTTTGAGAATT CGGAGAGATGTCATG
TGCCCCAAAACTGAA AGTCTTTGAGAATTT GGAGAGATGTCATGC GCCCCAAAACTGAAG
GTCTTTGAGAATTTC GAGAGATGTCATGCA CCCCAAAACTGAAGC TCTTTGAGAATTTCC
AGAGATGTCATGCAA
CCCAAAACTGAAGCC CTTTGAGAATTTCCT GAGATGTCATGCAAG CCAAAACTGAAGCCG
TTTGAGAATTTCCTG AGATGTCATGCAAGT GATGTCATGCAAGTG CGCAGACACCTACAA
TTGAGAGCAGAGTGG ATGTCATGCAAGTGG GCAGACACCTACAAC TGAGAGCAGAGTGGA
TGTCATGCAAGTGGC CAGACACCTACAACA GAGAGCAGAGTGGAT GTCATGCAAGTGGCC
AGACACCTACAACAT AGAGCAGAGTGGATA TCATGCAAGTGGCCA GACACCTACAACATC
GAGCAGAGTGGATAA CATGCAAGTGGCCAA ACACCTACAACATCA AGCAGAGTGGATAAC
ATGCAAGTGGCCAAC CACCTACAACATCAC GCAGAGTGGATAACA TGCAAGTGGCCAACA
ACCTACAACATCACC CAGAGTGGATAACAA GCAAGTGGCCAACAC CCTACAACATCACCG
AGAGTGGATAACAAG CAAGTGGCCAACACC CTACAACATCACCGA GAGTGGATAACAAGG
AAGTGGCCAACACCA TACAACATCACCGAC AGTGGATAACAAGGA AGTGGCCAACACCAC
ACAACATCACCGACC GTGGATAACAAGGAG GTGGCCAACACCACC CAACATCACCGACCC
TGGATAACAAGGAGA TGGCCAACACCACCA AACATCACCGACCCG GGATAACAAGGAGAG
GGCCAACACCACCAT ACATCACCGACCCGG GATAACAAGGAGAGA GCCAACACCACCATG
CATCACCGACCCGGA ATAACAAGGAGAGAA CCAACACCACCATGT ATCACCGACCCGGAA
TAACAAGGAGAGAAC CAACACCACCATGTC TCACCGACCCGGAAG AACAAGGAGAGAACT
AACACCACCATGTCC CACCGACCCGGAAGA ACAAGGAGAGAACTG ACACCACCATGTCCA
ACCGACCCGGAAGAG CAAGGAGAGAACTGT CACCACCATGTCCAG CCGACCCGGAAGAGC
AAGGAGAGAACTGTC ACCACCATGTCCAGC CGACCCGGAAGAGCT AGGAGAGAACTGTCA
CCACCATGTCCAGCC GACCCGGAAGAGCTG GGAGAGAACTGTCAT CACCATGTCCAGCCG
ACCCGGAAGAGCTGG GAGAGAACTGTCATT ACCATGTCCAGCCGA CCCGGAAGAGCTGGA
AGAGAACTGTCATTT CCATGTCCAGCCGAA CCGGAAGAGCTGGAG GAGAACTGTCATTTC
CATGTCCAGCCGAAG CGGAAGAGCTGGAGA AGAACTGTCATTTCT ATGTCCAGCCGAAGC
GGAAGAGCTGGAGAC GAACTGTCATTTCTA TGTCCAGCCGAAGCA GAAGAGCTGGAGACA
AACTGTCATTTCTAA GTCCAGCCGAAGCAG AAGAGCTGGAGACAG ACTGTCATTTCTAAC
TCCAGCCGAAGCAGG AGAGCTGGAGACAGA CTGTCATTTCTAACC CCAGCCGAAGCAGGA
GAGCTGGAGACAGAG TGTCATTTCTAACCT CAGCCGAAGCAGGAA AGCTGGAGACAGAGT
GTCATTTCTAACCTT AGCCGAAGCAGGAAC GCTGGAGACAGAGTA TCATTTCTAACCTTC
GCCGAAGCAGGAACA CTGGAGACAGAGTAC CATTTCTAACCTTCG CCGAAGCAGGAACAC
TGGAGACAGAGTACC ATTTCTAACCTTCGG CGAAGCAGGAACACC GGAGACAGAGTACCC
TTTCTAACCTTCGGC GAAGCAGGAACACCA GAGACAGAGTACCCT TTCTAACCTTCGGCC
AAGCAGGAACACCAC AGACAGAGTACCCTT TCTAACCTTCGGCCT AGCAGGAACACCACG
GACAGAGTACCCTTT CTAACCTTCGGCCTT GCAGGAACACCACGG ACAGAGTACCCTTTC
TAACCTTCGGCCTTT CAGGAACACCACGGC CAGAGTACCCTTTCT AACCTTCGGCCTTTC
AGGAACACCACGGCC AGAGTACCCTTTCTT ACCTTCGGCCTTTCA GGAACACCACGGCCG
GAGTACCCTTTCTTT CCTTCGGCCTTTCAC GAACACCACGGCCGC AGTACCCTTTCTTTG
CTTCGGCCTTTCACA AACACCACGGCCGCA GTACCCTTTCTTTGA TTCGGCCTTTCACAT
ACACCACGGCCGCAG TACCCTTTCTTTGAG TCGGCCTTTCACATT CACCACGGCCGCAGA
ACCCTTTCTTTGAGA CGGCCTTTCACATTG ACCACGGCCGCAGAC CCCTTTCTTTGAGAG
GGCCTTTCACATTGT CCACGGCCGCAGACA CCTTTCTTTGAGAGC GCCTTTCACATTGTA
CACGGCCGCAGACAC CTTTCTTTGAGAGCA CCTTTCACATTGTAC ACGGCCGCAGACACC
TTTCTTTGAGAGCAG CTTTCACATTGTACC CGGCCGCAGACACCT TTCTTTGAGAGCAGA
TTTCACATTGTACCG GGCCGCAGACACCTA TCTTTGAGAGCAGAG TTCACATTGTACCGC
GCCGCAGACACCTAC CTTTGAGAGCAGAGT TCACATTGTACCGCA CCGCAGACACCTACA
TTTGAGAGCAGAGTG CACATTGTACCGCAT ACATTGTACCGCATC CAGCGCCTCCAACTT
TTCCTGGGCCAGTGA CATTGTACCGCATCG AGCGCCTCCAACTTC TCCTGGGCCAGTGAC
ATTGTACCGCATCGA GCGCCTCCAACTTCG CCTGGGCCAGTGACC TTGTACCGCATCGAT
CGCCTCCAACTTCGT CTGGGCCAGTGACCT TGTACCGCATCGATA GCCTCCAACTTCGTC
TGGGCCAGTGACCTG GTACCGCATCGATAT CCTCCAACTTCGTCT GGGCCAGTGACCTGG
TACCGCATCGATATC CTCCAACTTCGTCTT GGCCAGTGACCTGGG ACCGCATCGATATCC
TCCAACTTCGTCTTT GCCAGTGACCTGGGA CCGCATCGATATCCA CCAACTTCGTCTTTG
CCAGTGACCTGGGAG CGCATCGATATCCAC CAACTTCGTCTTTGC CAGTGACCTGGGAGC
GCATCGATATCCACA AACTTCGTCTTTGCA AGTGACCTGGGAGCC CATCGATATCCACAG
ACTTCGTCTTTGCAA GTGACCTGGGAGCCA ATCGATATCCACAGC CTTCGTCTTTGCAAG
TGACCTGGGAGCCAA TCGATATCCACAGCT TTCGTCTTTGCAAGG GACCTGGGAGCCAAG
CGATATCCACAGCTG TCGTCTTTGCAAGGA ACCTGGGAGCCAAGG GATATCCACAGCTGC
CGTCTTTGCAAGGAC CCTGGGAGCCAAGGC ATATCCACAGCTGCA GTCTTTGCAAGGACT
CTGGGAGCCAAGGCC TATCCACAGCTGCAA TCTTTGCAAGGACTA TGGGAGCCAAGGCCT
ATCCACAGCTGCAAC CTTTGCAAGGACTAT GGGAGCCAAGGCCTG TCCACAGCTGCAACC
TTTGCAAGGACTATG GGAGCCAAGGCCTGA CCACAGCTGCAACCA TTGCAAGGACTATGC
GAGCCAAGGCCTGAA CACAGCTGCAACCAC TGCAAGGACTATGCC AGCCAAGGCCTGAAA
ACAGCTGCAACCACG GCAAGGACTATGCCC GCCAAGGCCTGAAAA CAGCTGCAACCACGA
CAAGGACTATGCCCG CCAAGGCCTGAAAAC AGCTGCAACCACGAG AAGGACTATGCCCGC
CAAGGCCTGAAAACT GCTGCAACCACGAGG AGGACTATGCCCGCA AAGGCCTGAAAACTC
CTGCAACCACGAGGC GGACTATGCCCGCAG AGGCCTGAAAACTCC TGCAACCACGAGGCT
GACTATGCCCGCAGA GGCCTGAAAACTCCA GCAACCACGAGGCTG ACTATGCCCGCAGAA
GCCTGAAAACTCCAT CAACCACGAGGCTGA CTATGCCCGCAGAAG CCTGAAAACTCCATC
AACCACGAGGCTGAG TATGCCCGCAGAAGG CTGAAAACTCCATCT ACCACGAGGCTGAGA
ATGCCCGCAGAAGGA TGAAAACTCCATCTT CCACGAGGCTGAGAA TGCCCGCAGAAGGAG
GAAAACTCCATCTTT CACGAGGCTGAGAAG GCCCGCAGAAGGAGC AAAACTCCATCTTTT
ACGAGGCTGAGAAGC CCCGCAGAAGGAGCA AAACTCCATCTTTTT CGAGGCTGAGAAGCT
CCGCAGAAGGAGCAG AACTCCATCTTTTTA GAGGCTGAGAAGCTG CGCAGAAGGAGCAGA
ACTCCATCTTTTTAA AGGCTGAGAAGCTGG GCAGAAGGAGCAGAT CTCCATCTTTTTAAA
GGCTGAGAAGCTGGG CAGAAGGAGCAGATG TCCATCTTTTTAAAG GCTGAGAAGCTGGGC
AGAAGGAGCAGATGA CCATCTTTTTAAAGT CTGAGAAGCTGGGCT GAAGGAGCAGATGAC
CATCTTTTTAAAGTG TGAGAAGCTGGGCTG AAGGAGCAGATGACA ATCTTTTTAAAGTGG
GAGAAGCTGGGCTGC AGGAGCAGATGACAT TCTTTTTAAAGTGGC AGAAGCTGGGCTGCA
GGAGCAGATGACATT CTTTTTAAAGTGGCC GAAGCTGGGCTGCAG GAGCAGATGACATTC
TTTTTAAAGTGGCCG AAGCTGGGCTGCAGC AGCAGATGACATTCC TTTTAAAGTGGCCGG
AGCTGGGCTGCAGCG GCAGATGACATTCCT TTTAAAGTGGCCGGA GCTGGGCTGCAGCGC
CAGATGACATTCCTG TTAAAGTGGCCGGAA CTGGGCTGCAGCGCC AGATGACATTCCTGG
TAAAGTGGCCGGAAC TGGGCTGCAGCGCCT GATGACATTCCTGGG AAAGTGGCCGGAACC
GGGCTGCAGCGCCTC ATGACATTCCTGGGC AAGTGGCCGGAACCT GGCTGCAGCGCCTCC
TGACATTCCTGGGCC AGTGGCCGGAACCTG GCTGCAGCGCCTCCA GACATTCCTGGGCCA
GTGGCCGGAACCTGA CTGCAGCGCCTCCAA ACATTCCTGGGCCAG TGGCCGGAACCTGAG
TGCAGCGCCTCCAAC CATTCCTGGGCCAGT GGCCGGAACCTGAGA GCAGCGCCTCCAACT
ATTCCTGGGCCAGTG GCCGGAACCTGAGAA CCGGAACCTGAGAAT ACAAGTTGAGGATCA
GGGCCAAGCTAAACC CGGAACCTGAGAATC CAAGTTGAGGATCAG GGCCAAGCTAAACCG
GGAACCTGAGAATCC AAGTTGAGGATCAGC GCCAAGCTAAACCGG GAACCTGAGAATCCC
AGTTGAGGATCAGCG CCAAGCTAAACCGGC AACCTGAGAATCCCA GTTGAGGATCAGCGA
CAAGCTAAACCGGCT ACCTGAGAATCCCAA TTGAGGATCAGCGAG AAGCTAAACCGGCTA
CCTGAGAATCCCAAT TGAGGATCAGCGAGA AGCTAAACCGGCTAA CTGAGAATCCCAATG
GAGGATCAGCGAGAA GCTAAACCGGCTAAA TGAGAATCCCAATGG AGGATCAGCGAGAAT
CTAAACCGGCTAAAC GAGAATCCCAATGGA GGATCAGCGAGAATG TAAACCGGCTAAACC
AGAATCCCAATGGAT GATCAGCGAGAATGT AAACCGGCTAAACCC GAATCCCAATGGATT
ATCAGCGAGAATGTG AACCGGCTAAACCCG AATCCCAATGGATTG TCAGCGAGAATGTGT
ACCGGCTAAACCCGG ATCCCAATGGATTGA CAGCGAGAATGTGTG CCGGCTAAACCCGGG
TCCCAATGGATTGAT AGCGAGAATGTGTGT CGGCTAAACCCGGGG CCCAATGGATTGATT
GCGAGAATGTGTGTC GGCTAAACCCGGGGA CCAATGGATTGATTC CGAGAATGTGTGTCC
GCTAAACCCGGGGAA CAATGGATTGATTCT GAGAATGTGTGTCCA CTAAACCCGGGGAAC
AATGGATTGATTCTA AGAATGTGTGTCCAG TAAACCCGGGGAACT ATGGATTGATTCTAA
GAATGTGTGTCCAGA AAACCCGGGGAACTA TGGATTGATTCTAAT AATGTGTGTCCAGAC
AACCCGGGGAACTAC GGATTGATTCTAATG ATGTGTGTCCAGACA ACCCGGGGAACTACA
GATTGATTCTAATGT TGTGTGTCCAGACAG CCCGGGGAACTACAC ATTGATTCTAATGTA
GTGTGTCCAGACAGG CCGGGGAACTACACA TTGATTCTAATGTAT TGTGTCCAGACAGGA
CGGGGAACTACACAG TGATTCTAATGTATG GTGTCCAGACAGGAA GGGGAACTACACAGC
GATTCTAATGTATGA TGTCCAGACAGGAAT GGGAACTACACAGCC ATTCTAATGTATGAA
GTCCAGACAGGAATA GGAACTACACAGCCC TTCTAATGTATGAAA TCCAGACAGGAATAC
GAACTACACAGCCCG TCTAATGTATGAAAT CCAGACAGGAATACA AACTACACAGCCCGG
CTAATGTATGAAATA CAGACAGGAATACAG ACTACACAGCCCGGA TAATGTATGAAATAA
AGACAGGAATACAGG CTACACAGCCCGGAT AATGTATGAAATAAA GACAGGAATACAGGA
TACACAGCCCGGATT ATGTATGAAATAAAA ACAGGAATACAGGAA ACACAGCCCGGATTC
TGTATGAAATAAAAT CAGGAATACAGGAAG CACAGCCCGGATTCA GTATGAAATAAAATA
AGGAATACAGGAAGT ACAGCCCGGATTCAG TATGAAATAAAATAC GGAATACAGGAAGTA
CAGCCCGGATTCAGG ATGAAATAAAATACG GAATACAGGAAGTAT AGCCCGGATTCAGGC
TGAAATAAAATACGG AATACAGGAAGTATG GCCCGGATTCAGGCC GAAATAAAATACGGA
ATACAGGAAGTATGG CCCGGATTCAGGCCA AAATAAAATACGGAT TACAGGAAGTATGGA
CCGGATTCAGGCCAC AATAAAATACGGATC ACAGGAAGTATGGAG CGGATTCAGGCCACA
ATAAAATACGGATCA CAGGAAGTATGGAGG GGATTCAGGCCACAT TAAAATACGGATCAC
AGGAAGTATGGAGGG GATTCAGGCCACATC AAAATACGGATCACA GGAAGTATGGAGGGG
ATTCAGGCCACATCT AAATACGGATCACAA GAAGTATGGAGGGGC TTCAGGCCACATCTC
AATACGGATCACAAG AAGTATGGAGGGGCC TCAGGCCACATCTCT ATACGGATCACAAGT
AGTATGGAGGGGCCA CAGGCCACATCTCTC TACGGATCACAAGTT GTATGGAGGGGCCAA
AGGCCACATCTCTCT ACGGATCACAAGTTG TATGGAGGGGCCAAG GGCCACATCTCTCTC
CGGATCACAAGTTGA ATGGAGGGGCCAAGC GCCACATCTCTCTCT GGATCACAAGTTGAG
TGGAGGGGCCAAGCT CCACATCTCTCTCTG GATCACAAGTTGAGG GGAGGGGCCAAGCTA
CACATCTCTCTCTGG ATCACAAGTTGAGGA GAGGGGCCAAGCTAA ACATCTCTCTCTGGG
TCACAAGTTGAGGAT AGGGGCCAAGCTAAA CATCTCTCTCTGGGA CACAAGTTGAGGATC
GGGGCCAAGCTAAAC ATCTCTCTCTGGGAA TCTCTCTCTGGGAAT AACAGGATATGAAAA
TGATCGTGGGAGGGT CTCTCTCTGGGAATG ACAGGATATGAAAAC GATCGTGGGAGGGTT
TCTCTCTGGGAATGG CAGGATATGAAAACT ATCGTGGGAGGGTTG CTCTCTGGGAATGGG
AGGATATGAAAACTT TCGTGGGAGGGTTGG TCTCTGGGAATGGGT GGATATGAAAACTTC
CGTGGGAGGGTTGGT CTCTGGGAATGGGTC GATATGAAAACTTCA GTGGGAGGGTTGGTG
TCTGGGAATGGGTCG ATATGAAAACTTCAT TGGGAGGGTTGGTGA CTGGGAATGGGTCGT
TATGAAAACTTCATC GGGAGGGTTGGTGAT TGGGAATGGGTCGTG ATGAAAACTTCATCC
GGAGGGTTGGTGATT GGGAATGGGTCGTGG TGAAAACTTCATCCA GAGGGTTGGTGATTA
GGAATGGGTCGTGGA GAAAACTTCATCCAT AGGGTTGGTGATTAT GAATGGGTCGTGGAC
AAAACTTCATCCATC GGGTTGGTGATTATG AATGGGTCGTGGACA AAACTTCATCCATCT
GGTTGGTGATTATGC ATGGGTCGTGGACAG AACTTCATCCATCTG GTTGGTGATTATGCT
TGGGTCGTGGACAGA ACTTCATCCATCTGA TTGGTGATTATGCTG GGGTCGTGGACAGAT
CTTCATCCATCTGAT TGGTGATTATGCTGT GGTCGTGGACAGATC TTCATCCATCTGATC
GGTGATTATGCTGTA GTCGTGGACAGATCC TCATCCATCTGATCA GTGATTATGCTGTAC
TCGTGGACAGATCCT CATCCATCTGATCAT TGATTATGCTGTACG CGTGGACAGATCCTG
ATCCATCTGATCATC GATTATGCTGTACGT GTGGACAGATCCTGT TCCATCTGATCATCG
ATTATGCTGTACGTC TGGACAGATCCTGTG CCATCTGATCATCGC TTATGCTGTACGTCT
GGACAGATCCTGTGT CATCTGATCATCGCT TATGCTGTACGTCTT GACAGATCCTGTGTT
ATCTGATCATCGCTC ATGCTGTACGTCTTC ACAGATCCTGTGTTC TCTGATCATCGCTCT
TGCTGTACGTCTTCC CAGATCCTGTGTTCT CTGATCATCGCTCTG GCTGTACGTCTTCCA
AGATCCTGTGTTCTT TGATCATCGCTCTGC CTGTACGTCTTCCAT GATCCTGTGTTCTTC
GATCATCGCTCTGCC TGTACGTCTTCCATA ATCCTGTGTTCTTCT ATCATCGCTCTGCCC
GTACGTCTTCCATAG TCCTGTGTTCTTCTA TCATCGCTCTGCCCG TACGTCTTCCATAGA
CCTGTGTTCTTCTAT CATCGCTCTGCCCGT ACGTCTTCCATAGAA CTGTGTTCTTCTATG
ATCGCTCTGCCCGTC CGTCTTCCATAGAAA TGTGTTCTTCTATGT TCGCTCTGCCCGTCG
GTCTTCCATAGAAAG GTGTTCTTCTATGTC CGCTCTGCCCGTCGC TCTTCCATAGAAAGA
TGTTCTTCTATGTCC GCTCTGCCCGTCGCT CTTCCATAGAAAGAG GTTCTTCTATGTCCA
CTCTGCCCGTCGCTG TTCCATAGAAAGAGA TTCTTCTATGTCCAG TCTGCCCGTCGCTGT
TCCATAGAAAGAGAA TCTTCTATGTCCAGG CTGCCCGTCGCTGTC CCATAGAAAGAGAAA
CTTCTATGTCCAGGC TGCCCGTCGCTGTCC CATAGAAAGAGAAAT TTCTATGTCCAGGCC
GCCCGTCGCTGTCCT ATAGAAAGAGAAATA TCTATGTCCAGGCCA CCCGTCGCTGTCCTG
TAGAAAGAGAAATAA CTATGTCCAGGCCAA CCGTCGCTGTCCTGT AGAAAGAGAAATAAC
TATGTCCAGGCCAAA CGTCGCTGTCCTGTT GAAAGAGAAATAACA ATGTCCAGGCCAAAA
GTCGCTGTUCTGTTG AAAGAGAAATAACAG TGTCCAGGCCAAAAC TCGCTGTCCTGTTGA
AAGAGAAATAACAGC GTCCAGGCCAAAACA CGCTGTCCTGTTGAT AGAGAAATAACAGCA
TCCAGGCCAAAACAG GCTGTCCTGTTGATC GAGAAATAACAGCAG CCAGGCCAAAACAGG
CTGTCCTGTTGATCG AGAAATAACAGCAGG CAGGCCAAAACAGGA TGTCCTGTTGATCGT
GAAATAACAGCAGGC AGGCCAAAACAGGAT GTCCTGTTGATCGTG AAATAACAGCAGGCT
GGCCAAAACAGGATA TCCTGTTGATCGTGG AATAACAGCAGGCTG GCCAAAACAGGATAT
CCTGTTGATCGTGGG ATAACAGCAGGCTGG CCAAAACAGGATATG CTGTTGATCGTGGGA
TAACAGCAGGCTGGG CAAAACAGGATATGA TGTTGATCGTGGGAG AACAGCAGGCTGGGG
AAAACAGGATATGAA GTTGATCGTGGGAGG ACAGCAGGCTGGGGA AAACAGGATATGAAA
TTGATCGTGGGAGGG CAGCAGGCTGGGGAA AGCAGGCTGGGGAAT TGCTGATGTGTACGT
GCCGGGAACTTGGGC GCAGGCTGGGGAATG GCTGATGTGTACGTT CCGGGAACTTGGGCA
CAGGCTGGGCAATGG CTGATGTGTACGTTC CGGGAACTTGGGCAG AGGCTGGGGAATGGA
TGATGTGTACGTTCC GGGAACTTGGGCAGG GGCTGGGGAATGGAG GATGTGTACGTTCCT
GGAACTTGGGCAGGG GCTGGGGAATGGAGT ATGTGTACGTTCCTG GAACTTGGGCAGGGG
CTGGGGAATGGAGTG TGTGTACGTTCCTGA AACTTGGGCAGGGGT TGGGGAATGGAGTGC
GTGTACGTTCCTGAT ACTTGGGCAGGGGTC GGGGAATGGAGTGCT TGTACGTTCCTGATG
CTTGGGCAGGGGTCG GGGAATGGAGTGCTG GTACGTTCCTGATGA TTGGGCAGGGGTCGT
GGAATGGAGTGCTGT TACGTTCCTGATGAG TGGGCAGGGGTCGTT GAATGGAGTGCTGTA
ACGTTCCTGATGAGT GGGCAGGGGTCGTTT AATGGAGTGCTGTAT CGTTCCTGATGAGTG
GGCAGGGGTCGTTTG ATGGAGTGCTGTATG GTTCCTGATGAGTGG GCAGGGGTCGTTTGG
TGGAGTGCTGTATGC TTCCTGATGAGTGGG CAGGGGTCGTTTGGG GGAGTGCTGTATGCC
TCCTGATGAGTGGGA AGGGGTCGTTTGGGA GAGTGCTGTATGCCT CCTGATGAGTGGGAG
GGGGTCGTTTGGGAT AGTGCTGTATGCCTC CTGATGAGTGGGAGG GGGTCGTTTGGGATG
GTGCTGTATGCCTCT TGATGAGTGGGAGGT GGTCGTTTGGGATGG TGCTGTATGCCTCTG
GATGAGTGGGAGGTG GTCGTTTGGGATGGT GCTGTATGCCTCTGT ATGAGTGGGAGGTGG
TCGTTTGGGATGGTC CTGTATGCCTCTGTG TGAGTGGGAGGTGGC CGTTTGGGATGGTCT
TGTATGCCTCTGTGA GAGTGGGAGGTGGCT GTTTGGGATGGTCTA GTATGCCTCTGTGAA
AGTGGGAGGTGGCTC TTTGGGATGGTCTAT TATGCCTCTGTGAAC GTGGGAGGTGGCTCG
TTGGGATGGTCTATG
ATGCCTCTGTGAACC TGGGAGGTGGCTCGG TGGGATGGTCTATGA TGCCTCTGTGAACCC
GGGAGGTGGCTCGGG GGGATGGTCTATGAA GCCTCTGTGAACCCG GGAGGTGGCTCGGGA
GGATGGTCTATGAAG CCTCTGTGAACCCGG GAGGTGGCTCGGGAG GATGGTCTATGAAGG
CTCTGTGAACCCGGA AGGTGGCTCGGGAGA ATGGTCTATGAAGGA TCTGTGAACCCGGAG
GGTGGCTCGGGAGAA TGGTCTATGAAGGAG CTGTGAACCCGGAGT GTGGCTCGGGAGAAG
GGTCTATGAAGGAGT TGTGAACCCGGAGTA TGGCTCGGGAGAAGA GTCTATGAAGGAGTT
GTGAACCCGGAGTAC GGCTCGGGAGAAGAT TCTATGAAGGAGTTG TGAACCCGGAGTACT
GCTCGGGAGAAGATC CTATGAAGGAGTTGC GAACCCGGAGTACTT CTCGGGAGAAGATCA
TATGAAGGAGTTGCC AACCCGGAGTACTTC TCGGGAGAAGATCAC ATGAAGGAGTTGCCA
ACCCGGAGTACTTCA CGGGAGAAGATCACC TGAAGGAGTTGCCAA CCCGGAGTACTTCAG
GGGAGAAGATCACCA GAAGGAGTTGCCAAG CCGGAGTACTTCAGC GGAGAAGATCACCAT
AAGGAGTTGCCAAGG CGGAGTACTTCAGCG GAGAAGATCACCATG AGGAGTTGCCAAGGG
GGAGTACTTCAGCGC AGAAGATCACCATGA GGAGTTGCCAAGGGT GAGTACTTCAGCGCT
GAAGATCACCATGAG GAGTTGCCAAGGGTG AGTACTTCAGCGCTG AAGATCACCATGAGC
AGTTGCCAAGGGTGT GTACTTCAGCGCTGC AGATCACCATGAGCC GTTGCCAAGGGTGTG
TACTTCAGCGCTGCT GATCACCATGAGCCG TTGCCAAGGGTGTGG ACTTCAGCGCTGCTG
ATCACCATGAGCCGG TGCCAAGGGTGTGGT CTTCAGCGCTGCTGA TCACCATGAGCCGGG
GCCAAGGGTGTGGTG TTCAGCGCTGCTGAT CACCATGAGCCGGGA CCAAGGGTGTGGTGA
TCAGCGCTGCTGATG ACCATGAGCCGGGAA CAAGGGTGTGGTGAA CAGCGCTGCTGATGT
CCATGAGCCGGGAAC AAGGGTGTGGTGAAA AGCGCTGCTGATGTG CATGAGCCGGGAACT
AGGGTGTGGTGAAAG GCGCTGCTGATGTGT ATGAGCCGGGAACTT GGGTGTGGTGAAAGA
CGCTGCTGATGTGTA TGAGCCGGGAACTTG GGTGTGGTGAAAGAT GCTGCTGATGTGTAC
GAGCCGGGAACTTGG GTGTGGTGAAAGATG CTGCTGATGTGTACG AGCCGGGAACTTGGG
TGTGGTGAAAGATGA GTGGTGAAAGATCAA AAGCATGCGTGAGAG ATTGTCACCATGTGG
TGGTGAAAGATGAAC AGCATGCGTGAGAGG TTGTCACCATGTGGT GGTGAAAGATGAACC
GCATGCGTGAGAGGA TGTCACCATGTGGTG GTGAAAGATGAACCT CATGCGTGAGAGGAT
GTCACCATGTGGTGC TGAAAGATGAACCTG ATGCGTGAGAGGATT TCACCATGTGGTGCG
GAAAGATGAACCTGA TGCGTGAGAGGATTG CACCATGTGGTGCGA AAAGATGAACCTGAA
GCGTGAGAGGATTGA ACCATGTGGTGCGAT AAGATGAACCTGAAA CGTGAGAGGATTGAG
CCATGTGGTGCGATT AGATGAACCTGAAAC GTGAGAGGATTGAGT CATGTGGTGCGATTG
GATGAACCTGAAACC TGAGAGGATTGAGTT ATGTGGTGCGATTGC ATGAACCTGAAACCA
GAGAGGATTGAGTTT TGTGGTGCGATTGCT TGAACCTGAAACCAG AGAGGATTGAGTTTC
GTGGTGCGATTGCTG GAACCTGAAACCAGA GAGGATTGAGTTTCT TGGTGCGATTGCTGG
AACCTGAAACCAGAG AGGATTGAGTTTCTC GGTGCGATTGCTGGG ACCTGAAACCAGAGT
GGATTGAGTTTCTCA GTGCGATTGCTGGGT CCTGAAACCAGAGTG GATTGAGTTTCTCAA
TGCGATTGCTGGGTG CTGAAACCAGAGTGG ATTGAGTTTCTCAAC GCGATTGCTGGGTGT
TGAAACCAGAGTGGC TTGAGTTTCTCAACG CGATTGCTGGGTGTG GAAACCAGAGTGGCC
TGAGTTTCTCAACGA GATTGCTGGGTGTGG AAACCAGAGTGGCCA GAGTTTCTCAACGAA
ATTGCTGGGTGTGGT AACCAGAGTGGCCAT AGTTTCTCAACGAAG TTGCTGGGTGTGGTG
ACCAGAGTGGCCATT GTTTCTCAACGAAGC TGCTGGGTGTGGTGT CCAGAGTGGCCATTA
TTTCTCAACGAAGCT GCTGGGTGTGGTGTC CAGAGTGGCCATTAA TTCTCAACGAAGCTT
CTGGGTGTGGTGTCC AGAGTGGCCATTAAA TCTCAACGAAGCTTC TGGGTGTGGTGTCCC
GAGTGGCCATTAAAA CTCAACGAAGCTTCT GGGTGTGGTGTCCCA AGTGGCCATTAAAAC
TCAACGAAGCTTCTG GGTGTGGTGTCCCAA GTGGCCATTAAAACA CAACGAAGCTTCTGT
GTGTGGTGTCCCAAG TGGCCATTAAAACAG AACGAAGCTTCTGTG TGTGGTGTCCCAAGG
GGCCATTAAAACAGT ACGAAGCTTCTGTGA GTGGTGTCCCAAGGC GCCATTAAAACAGTG
CGAAGCTTCTGTGAT TGGTGTCCCAAGGCC CCATTAAAACAGTGA GAAGCTTCTGTGATG
GGTGTCCCAAGGCCA CATTAAAACAGTGAA AAGCTTCTGTGATGA GTGTCCCAAGGCCAG
ATTAAAACAGTGAAC AGCTTCTGTGATGAA TGTCCCAAGGCCAGC TTAAAACAGTGAACG
GCTTCTGTGATGAAG GTCCCAAGGCCAGCC TAAAACAGTGAACGA CTTCTGTGATGAAGG
TCCCAAGGCCAGCCA AAAACAGTGAACGAG TTCTGTGATGAAGGA CCCAAGGCCAGCCAA
AAACAGTGAACGAGG TCTGTGATGAAGGAG CCAAGGCCAGCCAAC AACAGTGAACGAGGC
CTGTGATGAAGGAGT CAAGGCCAGCCAACA ACAGTGAACGAGGCC TGTGATGAAGGAGTT
AAGGCCAGCCAACAC CAGTGAACGAGGCCG GTGATGAAGGAGTTC AGGCCAGCCAACACT
AGTGAACGAGGCCGC TGATGAAGGAGTTCA GGCCAGCCAACACTG GTGAACGAGGCCGCA
GATGAAGGAGTTCAA GCCAGCCAACACTGG TGAACGAGGCCGCAA ATGAAGGAGTTCAAT
CCAGCCAACACTGGT GAACGAGGCCGCAAG TGAAGGAGTTCAATT CAGCCAACACTGGTC
AACGAGGCCGCAAGC GAAGGAGTTCAATTG AGCCAACACTGGTCA ACGAGGCCGCAAGCA
AAGGAGTTCAATTGT GCCAACACTGGTCAT CGAGGCCGCAAGCAT AGGAGTTCAATTGTC
CCAACACTGGTCATC GAGGCCGCAAGCATG GGAGTTCAATTGTCA CAACACTGGTCATCA
AGGCCGCAAGCATGC GAGTTCAATTGTCAC AACACTGGTCATCAT GGCCGCAAGCATGCG
AGTTCAATTGTCACC ACACTGGTCATCATG GCCGCAAGCATGCGT GTTCAATTGTCACCA
CACTGGTCATCATGG CCGCAAGCATGCGTG TTCAATTGTCACCAT ACTGGTCATCATGGA
CGCAAGCATGCGTGA TCAATTGTCACCATG CTGGTCATCATGGAA GCAAGCATGCGTGAG
CAATTGTCACCATGT TGGTCATCATGGAAC CAAGCATGCGTGAGA AATTGTCACCATGTG
GGTCATCATGGAACT GTCATCATGGAACTG GCCAGAAATGGAGAA AGATGGCCGGAGAGA
TCATCATGGAACTGA CCAGAAATGGAGAAT GATGGCCGGAGAGAT CATCATGGAACTGAT
CAGAAATGGAGAATA ATGGCCGGAGAGATT ATCATGGAACTGATG AGAAATGGAGAATAA
TGGCCGGAGAGATTG TCATGGAACTGATGA GAAATGGAGAATAAT GGCCGGAGAGATTGC
CATGGAACTGATGAC AAATGGAGAATAATC GCCGGAGAGATTGCA ATGGAACTGATGACA
AATGGAGAATAATCC CCGGAGAGATTGCAG TGGAACTGATGACAC ATGGAGAATAATCCA
CGGAGAGATTGCAGA GGAACTGATGACACG TGGAGAATAATCCAG GGAGAGATTGCAGAC
GAACTGATGACACGG GGAGAATAATCCAGT GAGAGATTGCAGACG AACTGATGACACGGG
GAGAATAATCCAGTC AGAGATTGCAGACGG ACTGATGACACGGGG AGAATAATCCAGTCC
GAGATTGCAGACGGC CTGATGACACGGGGC GAATAATCCAGTCCT AGATTGCAGACGGCA
TGATGACACGGGGCG AATAATCCAGTCCTA GATTGCAGACGGCAT GATGACACGGGGCGA
ATAATCCAGTCCTAG ATTGCAGACGGCATG ATGACACGGGGCGAT TAATCCAGTCCTAGC
TTGCAGACGGCATGG TGACACGGGGCGATC AATCCAGTCCTAGCA TGCAGACGGCATGGC
GACACGGGGCGATCT ATCCAGTCCTAGCAC GCAGACGGCATGGCA ACACGGGGCGATCTC
TCCAGTCCTAGCACC CAGACGGCATGGCAT CACGGGGCGATCTCA CCAGTCCTAGCACCT
AGACGGCATGGCATA ACGGGGCGATCTCAA CAGTCCTAGCACCTC GACGGCATGGCATAC
CGGGGCGATCTCAAA AGTCCTAGCACCTCC ACGGCATGGCATACC GGGGCGATCTCAAAA
GTCCTAGCACCTCCA CGGCATGGCATACCT GGGCGATCTCAAAAG TCCTAGCACCTCCAA
GGCATGGCATACCTC GGCGATCTCAAAAGT CCTAGCACCTCCAAG GCATGGCATACCTCA
GCGATCTCAAAAGTT CTAGCACCTCCAAGC CATGGCATACCTCAA CGATCTCAAAAGTTA
TAGCACCTCCAAGCC ATGGCATACCTCAAC GATCTCAAAAGTTAT AGCACCTCCAAGCCT
TGGCATACCTCAACG ATCTCAAAAGTTATC GCACCTCCAAGCCTG GGCATACCTCAACGC
TCTCAAAAGTTATCT CACCTCCAAGCCTGA GCATACCTCAACGCC CTCAAAAGTTATCTC
ACCTCCAAGCCTGAG CATACCTCAACGCCA TCAAAAGTTATCTCC CCTCCAAGCCTGAGC
ATACCTCAACGCCAA CAAAAGTTATCTCCG CTCCAAGCCTGAGCA TACCTCAACGCCAAT
AAAAGTTATCTCCGG TCCAAGCCTGAGCAA ACCTCAACGCCAATA AAAGTTATCTCCGGT
CCAAGCCTGAGCAAG CCTCAACGCCAATAA AAGTTATCTCCGGTC CAAGCCTGAGCAAGA
CTCAACGCCAATAAG AGTTATCTCCGGTCT AAGCCTGAGCAAGAT TCAACGCCAATAAGT
GTTATCTCCGGTCTC AGCCTGAGCAAGATG CAACGCCAATAAGTT TTATCTCCGGTCTCT
GCCTGAGCAAGATGA AACGCCAATAAGTTC TATCTCCGGTCTCTG CCTGAGCAAGATGAT
ACGCCAATAAGTTCG ATCTCCGGTCTCTGA CTGAGCAAGATGATT CGCCAATAAGTTCGT
TCTCCGGTCTCTGAG TGAGCAAGATGATTC GCCAATAAGTTCGTC CTCCGGTCTCTGAGG
GAGCAAGATGATTCA CCAATAAGTTCGTCC TCCGGTCTCTGAGGC AGCAAGATGATTCAG
CAATAAGTTCGTCCA CCGGTCTCTGAGGCC GCAAGATGATTCAGA AATAAGTTCGTCCAC
CGGTCTCTGAGGCCA CAAGATGATTCAGAT ATAAGTTCGTCCACA GGTCTCTGAGGCCAG
AAGATGATTCAGATG TAAGTTCGTCCACAG GTCTCTGAGGCCAGA AGATGATTCAGATGG
AAGTTCGTCCACAGA TCTCTGAGGCCAGAA GATGATTCAGATGGC AGTTCGTCCACAGAG
CTCTGAGGCCAGAAA ATGATTCAGATGGCC GTTCGTCCACAGAGA TCTGAGGCCAGAAAT
TGATTCAGATGGCCG TTCGTCCACAGAGAC CTGAGGCCAGAAATG GATTCAGATGGCCGG
TCGTCCACAGAGACC TGAGGCCAGAAATGG ATTCAGATGGCCGGA CGTCCACAGAGACCT
GAGGCCAGAAATGGA TTCAGATGGCCGGAG GTCCACAGAGACCTT AGGCCAGAAATGGAG
TCAGATGGCCGGAGA TCCACAGAGACCTTG GGCCAGAAATGGAGA CAGATGGCCGGAGAG
CCACAGAGACCTTGC CACAGAGACCTTGCT CGGAGATTTTGGTAT GCAAAGGGCTGCTGC
ACAGAGACCTTGCTG GGAGATTTTGGTATG CAAAGGGCTGCTGCC CAGAGACCTTGCTGC
GAGATTTTGGTATGA AAAGGGCTGCTGCCC AGAGACCTTGCTGCC AGATTTTGGTATGAC
AAGGGCTGCTGCCCG GAGACCTTGCTGCCC GATTTTGGTATGACG AGGGCTGCTGCCCGT
AGACCTTGCTGCCCG ATTTTGGTATGACGC GGGCTGCTGCCCGTG GACCTTGCTGCCCGG
TTTTGGTATGACGCG GGCTGCTGCCCGTGC ACCTTGCTGCCCGGA TTTGGTATGACGCGA
GCTGCTGCCCGTGCG CCTTGCTGCCCGGAA TTGGTATGACGCGAG CTGCTGCCCGTGCGC
CTTGCTGCCCGGAAT TGGTATGACGCGAGA TGCTGCCCGTGCGCT TTGCTGCCCGGAATT
GGTATGACGCGAGAT GCTGCCCGTGCGCTG TGCTGCCCGGAATTG GTATGACGCGAGATA
CTGCCCGTGCGCTGG GCTGCCCGGAATTGC TATGACGCGAGATAT TGCCCGTGCGCTGGA
CTGCCCGGAATTGCA ATGACGCGAGATATC GCCCGTGCGCTGGAT TGCCCGGAATTGCAT
TGACGCGAGATATCT CCCGTGCGCTGGATG GCCCGGAATTGCATG GACGCGAGATATCTA
CCGTGCGCTGGATGT CCCGGAATTGCATGG ACGCGAGATATCTAT CGTGCGCTGGATGTC
CCGGAATTGCATGGT CGCGAGATATCTATG GTGCGCTGGATGTCT CGGAATTGCATGGTA
GCGAGATATCTATGA TGCGCTGGATGTCTC GGAATTGCATGGTAG CGAGATATCTATGAG
GCGCTGGATGTCTCC GAATTGCATGGTAGC GAGATATCTATGAGA CGCTGGATGTCTCCT
AATTGCATGGTAGCC AGATATCTATGAGAC GCTGGATGTCTCCTG ATTGCATGGTAGCCG
GATATCTATGAGACA CTGGATGTCTCCTGA TTGCATGGTAGCCGA ATATCTATGAGACAG
TGGATGTCTCCTGAG TGCATGGTAGCCGAA TATCTATGAGACAGA GGATGTCTCCTGAGT
GCATGGTAGCCGAAG ATCTATGAGACAGAC GATGTCTCCTGAGTC CATGGTAGCCGAAGA
TCTATGAGACAGACT ATGTCTCCTGAGTCC ATGGTAGCCGAAGAT CTATGAGACAGACTA
TGTCTCCTGAGTCCC TGGTAGCCGAAGATT TATGAGACAGACTAT GTCTCCTGAGTCCCT
GGTAGCCGAAGATTT ATGAGACAGACTATT TCTCCTGAGTCCCTC GTAGCCGAAGATTTC
TGAGACAGACTATTA CTCCTGAGTCCCTCA TAGCCGAAGATTTCA GAGACAGACTATTAC
TCCTGAGTCCCTCAA AGCCGAAGATTTCAC AGACAGACTATTACC CCTGAGTCCCTCAAG
GCCGAAGATTTCACA GACAGACTATTACCG CTGAGTCCCTCAAGG CCGAAGATTTCACAG
ACAGACTATTACCGG TGAGTCCCTCAAGGA CGAAGATTTCACAGT CAGACTATTACCGGA
GAGTCCCTCAAGGAT GAAGATTTCACAGTC AGACTATTACCGGAA AGTCCCTCAAGGATG
AAGATTTCACAGTCA GACTATTACCGGAAA GTCCCTCAAGGATGG AGATTTCACAGTCAA
ACTATTACCGGAAAG TCCCTCAAGGATGGA GATTTCACAGTCAAA CTATTACCGGAAAGG
CCCTCAAGGATGGAG ATTTCACAGTCAAAA TATTACCGGAAAGGA CCTCAAGGATGGAGT
TTTCACAGTCAAAAT ATTACCGGAAAGGAG CTCAAGGATGGAGTC TTCACAGTCAAAATC
TTACCGGAAAGGAGG TCAAGGATGGAGTCT TCACAGTCAAAATCG TACCGGAAAGGAGGC
CAAGGATGGAGTCTT CACAGTCAAAATCGG ACCGGAAAGGAGGCA AAGGATGGAGTCTTC
ACAGTCAAAATCGGA CCGGAAAGGAGGCAA AGGATGGAGTCTTCA CAGTCAAAATCGGAG
CGGAAAGGAGGCAAA GGATGGAGTCTTCAC AGTCAAAATCGGAGA GGAAAGGAGGCAAAG
GATGGAGTCTTCACC GTCAAAATCGGAGAT GAAAGGAGGCAAAGG ATGGAGTCTTCACCA
TCAAAATCGGAGATT AAAGGAGGCAAAGGG TGGAGTCTTCACCAC CAAAATCGGAGATTT
AAGGAGGCAAAGGGC GGAGTCTTCACCACT AAAATCGGAGATTTT AGGAGGCAAAGGGCT
GAGTCTTCACCACTT AAATCGGAGATTTTG GGAGGCAAAGGGCTG AGTCTTCACCACTTA
AATCGGAGATTTTGG GAGGCAAAGGGCTGC GTCTTCACCACTTAC ATCGGAGATTTTGGT
AGGCAAAGGGCTGCT TCTTCACCACTTACT TCGGAGATTTTGGTA GGCAAAGGGCTGCTG
CTTCACCACTTACTC TTCACCACTTACTCG ACTGGCCGAGCAGCC TGGAGGGCGGCCTTC
TCACCACTTACTCGG CTGGCCGAGCAGCCC GGAGGGCGGCCTTCT CACCACTTACTCGGA
TGGCCGAGCAGCCCT GAGGGCGGCCTTCTG ACCACTTACTCGGAC GGCCGAGCAGCCCTA
AGGGCGGCCTTCTGG CCACTTACTCGGACG GCCGAGCAGCCCTAC GGGCGGCCTTCTGGA
CACTTACTCGGACGT CCGAGCAGCCCTACC GGCGGCCTTCTGGAC ACTTACTCGGACGTC
CGAGCAGCCCTACCA GCGGCCTTCTGGACA CTTACTCGGACGTCT GAGCAGCCCTACCAG
CGGCCTTCTGGACAA TTACTCGGACGTCTG AGCAGCCCTACCAGG GGCCTTCTGGACAAG
TACTCGGACGTCTGG GCAGCCCTACCAGGG GCCTTCTGGACAAGC ACTCGGACGTCTGGT
CAGCCCTACCAGGGC CCTTCTGGACAAGCC CTCGGACGTCTGGTC AGCCCTACCAGGGCT
CTTCTGGACAAGCCA TCGGACGTCTGGTCC GCCCTACCAGGGCTT TTCTGGACAAGCCAG
CGGACGTCTGGTCCT CCCTACCAGGGCTTG TCTGGACAAGCCAGA GGACGTCTGGTCCTT
CCTACCAGGGCTTGT CTGGACAAGCCAGAC GACGTCTGGTCCTTC CTACCAGGGCTTGTC
TGGACAAGCCAGACA ACGTCTGGTCCTTCG TACCAGGGCTTGTCC GGACAAGCCAGACAA
CGTCTGGTCCTTCGG ACCAGGGCTTGTCCA GACAAGCCAGACAAC GTCTGGTCCTTCGGG
CCAGGGCTTGTCCAA ACAAGCCAGACAACT TCTGGTCCTTCGCGG CAGGGCTTGTCCAAC
CAAGCCAGACAACTG CTGGTCCTTCGGGGT AGGGCTTGTCCAACG AAGCCAGACAACTGT
TGGTCCTTCGGGGTC GGGCTTGTCCAACGA AGCCAGACAACTGTC GGTCCTTCGGGGTCG
GGCTTGTCCAACGAG GCCAGACAACTGTCC GTCCTTCGGGGTCGT GCTTGTCCAACGAGC
CCAGACAACTGTCCT TCCTTCGGGGTCGTC CTTGTCCAACGAGCA CAGACAACTGTCCTG
CCTTCGGGGTCGTCC TTGTCCAACGAGCAA ACACAACTGTCCTGA CTTCGGGGTCGTCCT
TGTCCAACGAGCAAG GACAACTGTCCTGAC TTCGGGGTCGTCCTC GTCCAACGAGCAAGT
ACAACTGTCCTGACA TCGGGGTCGTCCTCT TCCAACGAGCAAGTC CAACTGTCCTGACAT
CGGGGTCGTCCTCTG CCAACGAGCAAGTCC AACTGTCCTGACATG GGGGTCGTCCTCTGG
CAACGAGCAAGTCCT ACTGTCCTGACATGC GGGTCGTCCTCTGGG AACGAGCAAGTCCTT
CTGTCCTGACATGCT GGTCGTCCTCTGGGA ACGAGCAAGTCCTTC TGTCCTGACATGCTG
GTCGTCCTCTGGGAG CGAGCAAGTCCTTCG GTCCTGACATGCTGT TCGTCCTCTGGGAGA
GAGCAAGTCCTTCGC TCCTGACATGCTGTT CGTCCTCTGGGAGAT AGCAAGTCCTTCGCT
CCTGACATGCTGTTT GTCCTCTGGGAGATC GCAAGTCCTTCGCTT CTGACATGCTGTTTG
TCCTCTGGGAGATCG CAAGTCCTTCGCTTC TGACATGCTGTTTGA CCTCTGGGAGATCGC
AAGTCCTTCGCTTCG GACATGCTGTTTGAA CTCTGGGAGATCGCC AGTCCTTCGCTTCGT
ACATGCTGTTTGAAC TCTGGGAGATCGCCA GTCCTTCGCTTCGTC CATGCTGTTTGAACT
CTGGGAGATCGCCAC TCCTTCGCTTCGTCA ATGCTGTTTGAACTG TGGGAGATCGCCACA
CCTTCGCTTCGTCAT TGCTGTTTGAACTGA GGGAGATCGCCACAC CTTCGCTTCGTCATG
GCTGTTTGAACTGAT GGAGATCGCCACACT TTCGCTTCGTCATGG CTGTTTGAACTGATG
GAGATCGCCACACTG TCGCTTCGTCATGGA TGTTTGAACTGATGC AGATCGCCACACTGG
CGCTTCGTCATGGAG GTTTGAACTGATGCG GATCGCCACACTGGC GCTTCGTCATGGAGG
TTTGAACTGATGCGC ATCGCCACACTGGCC CTTCGTCATGGAGGG TTGAACTGATGCGCA
TCGCCACACTGGCCG TTCGTCATGGAGGGC TGAACTGATGCGCAT CGCCACACTGGCCGA
TCGTCATGGAGGGCG GAACTGATGCGCATG GCCACACTGGCCGAG CGTCATGGAGGGCGG
AACTGATGCGCATGT
CCACACTGGCCGAGC GTCATGGAGGGCGGC ACTGATGCGCATGTG CACACTGGCCGAGCA
TCATGGAGGGCGGCC CTGATGCGCATGTGC ACACTGGCCGAGCAG CATGGAGGGCGGCCT
TGATGCGCATGTGCT CACTGGCCGAGCAGC ATGGAGGGCGGCCTT GATGCGCATGTGCTG
ATGCGCATGTGCTGG CAGCAGCATCAAAGA GCGAGGAGAACAAGC TGCGCATGTGCTGGC
AGCAGCATCAAAGAG CGAGGAGAACAAGCT GCGCATGTGCTGGCA GCAGCATCAAAGAGG
GAGGAGAACAAGCTG CGCATGTGCTGGCAG CAGCATCAAAGAGGA AGGAGAACAAGCTGC
GCATGTGCTGGCAGT AGCATCAAAGAGGAG GGAGAACAAGCTGCC CATGTGCTGGCAGTA
GCATCAAAGAGGAGA GAGAACAAGCTGCCC ATGTGCTGGCAGTAT CATCAAAGAGGAGAT
AGAACAAGCTGCCCG TGTGCTGGCAGTATA ATCAAAGAGGAGATG GAACAAGCTGCCCGA
GTGCTGGCAGTATAA TCAAAGAGGAGATGG AACAAGCTGCCCGAG TGCTGGCAGTATAAC
CAAAGAGGAGATGGA ACAAGCTGCCCGAGC GCTGGCAGTATAACC AAAGAGGAGATGGAG
CAAGCTGCCCGAGCC CTGGCAGTATAACCC AAGAGGAGATGGAGC AAGCTGCCCGAGCCG
TGGCAGTATAACCCC AGAGGAGATGGAGCC AGCTGCCCGAGCCGG GGCAGTATAACCCCA
GAGGAGATGGAGCCT GCTGCCCGAGCCGGA GCAGTATAACCCCAA AGGAGATGGAGCCTG
CTGCCCGAGCCGGAG CAGTATAACCCCAAG GGAGATGGAGCCTGG TGCCCGAGCCGGAGG
AGTATAACCCCAAGA GAGATGGAGCCTGGC GCCCGAGCCGGAGGA GTATAACCCCAAGAT
AGATGGAGCCTGGCT CCCGAGCCGGAGGAG TATAACCCCAAGATG GATGGAGCCTGGCTT
CCGAGCCGGAGGAGC ATAACCCCAAGATGA ATGGAGCCTGGCTTC CGAGCCGGAGGAGCT
TAACCCCAAGATGAG TGGAGCCTGGCTTCC GAGCCGGAGGAGCTG AACCCCAAGATGAGG
GGAGCCTGGCTTCCG AGCCGGAGGAGCTGG ACCCCAAGATGAGGC GAGCCTGGCTTCCGG
GCCGGAGGAGCTGGA CCCCAAGATGAGGCC AGCCTGGCTTCCGGG CCGGAGGAGCTGGAC
CCCAAGATGAGGCCT GCCTGGCTTCCGGGA CGGAGGAGCTGGACC CCAAGATGAGGCCTT
CCTGGCTTCCGGGAG GGAGGAGCTGGACCT CAAGATGAGGCCTTC CTGGCTTCCGGGAGG
GAGGAGCTGGACCTG AAGATGAGGCCTTCC TGGCTTCCGGGAGGT AGGAGCTGGACCTGG
AGATGAGGCCTTCCT GGCTTCCGGGAGGTC GGAGCTGGACCTGGA GATGAGGCCTTCCTT
GCTTCCGGGAGGTCT GAGCTGGACCTGGAG ATGAGGCCTTCCTTC CTTCCGGGAGGTCTC
AGCTGGACCTGGAGC TGAGGCCTTCCTTCC TTCCGGGAGGTCTCC GCTGGACCTGGAGCC
GAGGCCTTCCTTCCT TCCGGGAGGTCTCCT CTGGACCTGGAGCCA AGGCCTTCCTTCCTG
CCGGGAGGTCTCCTT TGGACCTGGAGCCAG GGCCTTCCTTCCTGG CGGGAGGTCTCCTTC
GGACCTGGAGCCAGA GCCTTCCTTCCTGGA GGGAGGTCTCCTTCT GACCTGGAGCCAGAG
CCTTCCTTCCTGGAG GGAGGTCTCCTTCTA ACCTGGAGCCAGAGA CTTCCTTCCTGGAGA
GAGGTCTCCTTCTAC CCTGGAGCCAGAGAA TTCCTTCCTGGAGAT AGGTCTCCTTCTACT
CTGGAGCCAGAGAAC TCCTTCCTGGAGATC GGTCTCCTTCTACTA TGGAGCCAGAGAACA
CCTTCCTGGAGATCA GTCTCCTTCTACTAC GGAGCCAGAGAACAT CTTCCTGGAGATCAT
TCTCCTTCTACTACA GAGCCAGAGAACATG TTCCTGGAGATCATC CTCCTTCTACTACAG
AGCCAGAGAACATGG TCCTGGAGATCATCA TCCTTCTACTACAGC GCCAGAGAACATGGA
CCTGGAGATCATCAG CCTTCTACTACAGCG CCAGAGAACATGGAG CTGGAGATCATCAGC
CTTCTACTACAGCGA CAGAGAACATGGAGA TGGAGATCATCAGCA TTCTACTACAGCGAG
AGAGAACATGGAGAG GGAGATCATCAGCAG TCTACTACAGCGAGG GAGAACATGGAGAGC
GAGATCATCAGCAGC CTACTACAGCGAGGA AGAACATGGAGAGCG AGATCATCAGCAGCA
TACTACAGCGAGGAG GAACATGGAGAGCGT GATCATCAGCAGCAT ACTACAGCGAGGAGA
AACATGGAGAGCGTC ATCATCAGCAGCATC CTACAGCGAGGAGAA ACATGGAGAGCGTCC
TCATCAGCAGCATCA TACAGCGAGGAGAAC CATGGAGAGCGTCCC CATCAGCAGCATCAA
ACAGCGAGGAGAACA ATGGAGAGCGTCCCC ATCAGCAGCATCAAA CAGCGAGGAGAACAA
TGGAGAGCGTCCCCC TCAGCAGCATCAAAG AGCGAGGAGAACAAG GGAGAGCGTCCCCCT
GAGAGCGTCCCCCTG ACACTCAGGACACAA CCAGCTTCGACGAGA AGAGCGTCCCCCTGG
CACTCAGGACACAAG CAGCTTCGACGAGAG GAGCGTCCCCCTGGA ACTCAGGACACAAGG
AGCTTCGACGAGAGA AGCGTCCCCCTGGAC CTCAGGACACAAGGC GCTTCGACGAGAGAC
GCGTCCCCCTGGACC TCAGGACACAAGGCC CTTCGACGAGAGACA CGTCCCCCTGGACCC
CAGGACACAAGGCCG TTCGACGAGAGACAG GTCCCCCTGGACCCC AGGACACAAGGCCGA
TCGACGAGAGACAGC TCCCCCTGGACCCCT GGACACAAGGCCGAG CGACGAGAGACAGCC
CCCCCTGGACCCCTC GACACAAGGCCGAGA GACGAGAGACAGCCT CCCCTGGACCCCTCG
ACACAAGGCCGAGAA ACGAGAGACAGCCTT CCCTGGACCCCTCGG CACAAGGCCGAGAAC
CGAGAGACAGCCTTA CCTGGACCCCTCGGC ACAAGGCCGAGAACG GAGAGACAGCCTTAC
CTGGACCCCTCGGCC CAAGGCCGAGAACGG AGAGACAGCCTTACG TGGACCCCTCGGCCT
AAGGCCGAGAACGGC GAGACAGCCTTACGC GGACCCCTCGGCCTC AGGCCGAGAACGGCC
AGACAGCCTTACGCC GACCCCTCGGCCTCC GGCCGAGAACGGCCC GACAGCCTTACGCCC
ACCCCTCGGCCTCCT GCCGAGAACGGCCCC ACAGCCTTACGCCCA CCCCTCGGCCTCCTC
CCGAGAACGGCCCCG CAGCCTTACGCCCAC CCCTCGGCCTCCTCG CGAGAACGGCCCCGG
AGCCTTACGCCCACA CCTCGGCCTCCTCGT GAGAACGGCCCCGGC GCCTTACGCCCACAT
CTCGGCCTCCTCGTC AGAACGGCCCCGGCC CCTTACGCCCACATG TCGGCCTCCTCGTCC
GAACGGCCCCGGCCC CTTACGCCCACATGA CGGCCTCCTCGTCCT AACGGCCCCGGCCCT
TTACGCCCACATGAA GGCCTCCTCGTCCTC ACGGCCCCGGCCCTG TACGCCCACATGAAC
GCCTCCTCGTCCTCC CGGCCCCGGCCCTGG ACGCCCACATGAACG CCTCCTCGTCCTCCC
GGCCCCGGCCCTGGG CGCCCACATGAACGG CTCCTCGTCCTCCCT GCCCCGGCCCTGGGG
GCCCACATGAACGGG TCCTCGTCCTCCCTG CCCCGGCCCTGGGGT CCCACATGAACGGGG
CCTCGTCCTCCCTGC CCCGGCCCTGGGGTG CCACATGAACGGGGG CTCGTCCTCCCTGCC
CCGGCCCTGGGGTGC CACATGAACGGGGGC TCGTCCTCCCTGCCA CGGCCCTGGGGTGCT
ACATGAACGGGGGCC CGTCCTCCCTGCCAC GGCCCTGGGGTGCTG CATGAACGGGGGCCG
GTCCTCCCTGCCACT GCCCTGGGGTGCTGG ATGAACGGGGGCCGC TCCTCCCTGCCACTG
CCCTGGGGTGCTGGT TGAACGGGGGCCGCA CCTCCCTGCCACTGC CCTGGGGTGCTGGTC
GAACGGGGGCCGCAA CTCCCTGCCACTGCC CTGGGGTGCTGGTCC AACGGGGGCCGCAAG
TCCCTGCCACTGCCC TGGGGTGCTGGTCCT ACGGGGGCCGCAAGA CCCTGCCACTGCCCG
GGGGTGCTGGTCCTC CGGGGGCCGCAAGAA CCTGCCACTGCCCGA GGGTGCTGGTCCTCC
GGGGGCCGCAAGAAC CTGCCACTGCCCGAC GGTGCTGGTCCTCCG GGGGCCGCAAGAACG
TGCCACTGCCCGACA GTGCTGGTCCTCCGC GGGCCGCAAGAACGA GCCACTGCCCGACAG
TGCTGGTCCTCCGCG GGCCGCAAGAACGAG CCACTGCCCGACAGA GCTGGTCCTCCGCGC
GCCGCAAGAACGAGC CACTGCCCGACAGAC CTGGTCCTCCGCGCC CCGCAAGAACGAGCG
ACTGCCCGACAGACA TGGTCCTCCGCGCCA CGCAAGAACGAGCGG CTGCCCGACAGACAC
GGTCCTCCGCGCCAG GCAAGAACGAGCGGG TGCCCGACAGACACT GTCCTCCGCGCCAGC
CAAGAACGAGCGGGC GCCCGACAGACACTC TCCTCCGCGCCAGCT AAGAACGAGCGGGCC
CCCGACAGACACTCA CCTCCGCGCCAGCTT AGAACGAGCGGGCCT CCGACAGACACTCAG
CTCCGCGCCAGCTTC GAACGAGCGGGCCTT CGACAGACACTCAGG TCCGCGCCAGCTTCG
AACGAGCGGGCCTTG GACAGACACTCAGGA CCGCGCCAGCTTCGA ACGAGCGGGCCTTGC
ACAGACACTCAGGAC CGCGCCAGCTTCGAC CGAGCGGGCCTTGCC CAGACACTCAGGACA
GCGCCAGCTTCGACG GAGCGGGCCTTGCCG AGACACTCAGGACAC CGCCAGCTTCGACGA
AGCGGGCCTTGCCGC GACACTCAGGACACA GCCAGCTTCGACGAG GCGGCCCTTGCCGCT
CGGGCCTTGCCGCTG GCAAACAGTAACGTG CAATCCATTCACAAG GGGCCTTGCCGCTGC
CAAACAGTAACGTGT AATCCATTCACAAGC GGCCTTGCCGCTGCC AAACAGTAACGTGTG
ATCCATTCACAAGCC GCCTTGCCGCTGCCC AACAGTAACGTGTGC TCCATTCACAAGCCT
CCTTGCCGCTGCCCC ACAGTAACGTGTGCG CCATTCACAAGCCTC CTTGCCGCTGCCCCA
CAGTAACGTGTGCGC CATTCACAAGCCTCC TTGCCGCTGCCCCAG AGTAACGTGTGCGCA
ATTCACAAGCCTCCT TGCCGCTGCCCCAGT GTAACGTGTGCGCAC TTCACAAGCCTCCTG
GCCGCTGCCCCAGTC TAACGTGTGCGCACG TCACAAGCCTCCTGT CCGCTGCCCCAGTCT
AACGTGTGCGCACGC CACAAGCCTCCTGTA CGCTGCCCCAGTCTT ACGTGTGCGCACGCG
ACAAGCCTCCTGTAC GCTGCCCCAGTCTTC CGTGTGCGCACGCGC CAAGCCTCCTGTACC
CTGCCCCAGTCTTCG GTGTGCGCACGCGCA AAGCCTCCTGTACCT TGCCCCAGTCTTCGA
TGTGCGCACGCGCAG AGCCTCCTGTACCTC GCCCCAGTCTTCGAC GTGCGCACGCGCAGC
GCCTCCTGTACCTCA CCCCAGTCTTCGACC TGCGCACGCGCAGCG CCTCCTGTACCTCAG
CCCAGTCTTCGACCT GCGCACGCGCAGCGG CTCCTGTACCTCAGT CCAGTCTTCGACCTG
CGCACGCGCAGCGGG TCCTGTACCTCAGTG CAGTCTTCGACCTGC GCACGCGCAGCGGGG
CCTGTACCTCAGTGG AGTCTTCGACCTGCT CACGCGCAGCGGGGT CTGTACCTCAGTGGA
GTCTTCGACCTGCTG ACGCGCAGCGGGGTG TGTACCTCAGTGGAT TCTTCGACCTGCTGA
CGCGCAGCGGGGTGG GTACCTCAGTGGATC CTTCGACCTGCTGAT GCGCAGCGGGGTGGG
TACCTCAGTGGATCT TTCGACCTGCTGATC CGCAGCGGGGTGGGG ACCTCAGTGGATCTT
TCGACCTGCTGATCC GCAGCGGGGTGGGGG CCTCAGTGGATCTTC CGACCTGCTGATCCT
CAGCGGGGTGGGGGG CTCAGTGGATCTTCA GACCTGCTGATCCTT AGCGGGGTGGGGGGG
TCAGTGGATCTTCAG ACCTGCTGATCCTTG GCGGGGTGGGGGGGG CAGTGGATCTTCAGT
CCTGCTGATCCTTGG CGGGGTGGGGGGGGA AGTGGATCTTCAGTT CTGCTGATCCTTGGA
GGGGTGGGGGGGGAG GTGGATCTTCAGTTC TGCTGATCCTTGGAT GGGTGGGGGGGGAGA
TGGATCTTCAGTTCT GCTGATCCTTGGATC GGTGGGGGGGGAGAG GGATCTTCAGTTCTG
CTGATCCTTGGATCC GTGGGGGGGGAGAGA GATCTTCAGTTCTGC TGATCCTTGGATCCT
TGGGGGGGGAGAGAG ATCTTCAGTTCTGCC GATCCTTGGATCCTG GGGGGGGGAGAGAGA
TCTTCAGTTCTGCCC ATCCTTGGATCCTGA GGGGGGGAGAGAGAG CTTCAGTTCTGCCCT
TCCTTGGATCCTGAA GGGGGGAGAGAGAGT TTCAGTTCTGCCCTT CCTTGGATCCTGAAT
GGGGGAGAGAGAGTT TCAGTTCTGCCCTTG CTTGGATCCTGAATC GGGGAGAGAGAGTTT
CAGTTCTGCCCTTGC TTGGATCCTGAATCT GGGAGAGAGAGTTTT AGTTCTGCCCTTGCT
TGGATCCTGAATCTG GGAGAGAGAGTTTTA GTTCTGCCCTTGCTG GGATCCTGAATCTGT
GAGAGAGAGTTTTAA TTCTGCCCTTGCTGC GATCCTGAATCTGTG AGAGAGAGTTTTAAC
TCTGCCCTTGCTGCC ATCCTGAATCTGTGC GAGAGAGTTTTAACA CTGCCCTTGCTGCCC
TCCTGAATCTGTGCA AGAGAGTTTTAACAA TGCCCTTGCTGCCCG CCTGAATCTGTGCAA
GAGAGTTTTAACAAT GCCCTTGCTGCCCGC CTGAATCTGTGCAAA AGAGTTTTAACAATC
CCCTTGCTGCCCGCG TGAATCTGTGCAAAC GAGTTTTAACAATCC CCTTGCTGCCCGCGG
GAATCTGTGCAAACA AGTTTTAACAATCCA CTTGCTGCCCGCGGG AATCTGTGCAAACAG
GTTTTAACAATCCAT TTGCTGCCCGCGGGA ATCTGTGCAAACAGT TTTTAACAATCCATT
TGCTGCCCGCGGGAG TCTGTGCAAACAGTA TTTAACAATCCATTC GCTGCCCGCGGGAGA
CTGTGCAAACAGTAA TTAACAATCCATTCA CTGCCCGCGGGAGAC TGTGCAAACAGTAAC
TAACAATCCATTCAC TGCCCGCGGGAGACA GTGCAAACAGTAACG AACAATCCATTCACA
GCCCGCGGGAGACAG TGCAAACAGTAACGT ACAATCCATTCACAA CCCGCGGGAGACAGC
CCGCGGGAGACAGCT ATGCAAGCAGCTTTT ACCTTAATGACAACA CGCGGGAGACAGCTT
TGCAAGCAGCTTTTT CCTTAATGACAACAC GCGGGAGACAGCTTC GCAAGCAGCTTTTTA
CTTAATGACAACACT CGGGAGACAGCTTCT CAAGCAGCTTTTTAT TTAATGACAACACTT
GGGAGACAGCTTCTC AAGCAGCTTTTTATT TAATGACAACACTTA GGAGACAGCTTCTCT
AGCAGCTTTTTATTC AATGACAACACTTAA GAGACAGCTTCTCTG GCAGCTTTTTATTCC
ATGACAACACTTAAT AGACAGCTTCTCTGC CAGCTTTTTATTCCC TGACAACACTTAATA
GACAGCTTCTCTGCA AGCTTTTTATTCCCT GACAACACTTAATAG ACAGCTTCTCTGCAG
GCTTTTTATTCCCTG ACAACACTTAATAGC CAGCTTCTCTGCAGT CTTTTTATTCCCTGC
CAACACTTAATAGCA AGCTTCTCTGCAGTA TTTTTATTCCCTGCC AACACTTAATAGCAA
GCTTCTCTGCAGTAA TTTTATTCCCTGCCC ACACTTAATAGCAAC CTTCTCTGCAGTAAA
TTTATTCCCTGCCCA CACTTAATAGCAACA TTCTCTGCAGTAAAA TTATTCCCTGCCCAA
ACTTAATAGCAACAG TCTCTGCAGTAAAAC TATTCCCTGCCCAAA CTTAATAGCAACAGA
CTCTGCAGTAAAACA ATTCCCTGCCCAAAC TTAATAGCAACAGAG TCTGCAGTAAAACAC
TTCCCTGCCCAAACC TAATAGCAACAGAGC CTGCAGTAAAACACA TCCCTGCCCAAACCC
AATAGCAACAGAGCA TGCAGTAAAACACAT CCCTGCCCAAACCCT ATAGCAACAGAGCAC
GCAGTAAAACACATT CCTGCCCAAACCCTT TAGCAACAGAGCACT CAGTAAAACACATTT
CTGCCCAAACCCTTA AGCAACAGAGCACTT AGTAAAACACATTTG TGCCCAAACCCTTAA
GCAACAGAGCACTTG GTAAAACACATTTGG GCCCAAACCCTTAAC CAACAGAGCACTTGA
TAAAACACATTTGGG CCCAAACCCTTAACT AACAGAGCACTTGAG AAAACACATTTGGGA
CCAAACCCTTAACTG ACAGAGCACTTGAGA AAACACATTTGGGAT CAAACCCTTAACTGA
CAGAGCACTTGAGAA AACACATTTGGGATG AAACCCTTAACTGAC AGAGCACTTGAGAAC
ACACATTTGGGATGT AACCCTTAACTGACA GAGCACTTGAGAACC CACATTTGGGATGTT
ACCCTTAACTGACAT AGCACTTGAGAACCA ACATTTGGGATGTTC CCCTTAACTGACATG
GCACTTGAGAACCAG CATTTGGGATGTTCC CCTTAACTGACATGG CACTTGAGAACCAGT
ATTTGGGATGTTCCT CTTAACTGACATGGG ACTTGAGAACCAGTC TTTGGGATGTTCCTT
TTAACTGACATGGGC CTTGAGAACCAGTCT TTGGGATGTTCCTTT TAACTGACATGGGCC
TTGAGAACCAGTCTC TGGGATGTTCCTTTT AACTGACATGGGCCT TGAGAACCAGTCTCC
GGGATGTTCCTTTTT ACTGACATGGGCCTT GAGAACCAGTCTCCT GGATGTTCCTTTTTT
CTGACATGGGCCTTT AGAACCAGTCTCCTC GATGTTCCTTTTTTC TGACATGGGCCTTTA
GAACCAGTCTCCTCA ATGTTCCTTTTTTCA GACATGGGCCTTTAA AACCAGTCTCCTCAC
TGTTCCTTTTTTCAA ACATGGGCCTTTAAG ACCAGTCTCCTCACT GTTCCTTTTTTCAAT
CATGGGCCTTTAAGA CCAGTCTCCTCACTC TTCCTTTTTTCAATA ATGGGCCTTTAAGAA
CAGTCTCCTCACTCT TCCTTTTTTCAATAT TGGGCCTTTAAGAAC AGTCTCCTCACTCTG
CCTTTTTTCAATATG GGGCCTTTAAGAACC GTCTCCTCACTCTGT CTTTTTTCAATATGC
GGCCTTTAAGAACCT TCTCCTCACTCTGTC TTTTTTCAATATGCA GCCTTTAAGAACCTT
CTCCTCACTCTGTCC TTTTTCAATATGCAA CCTTTAAGAACCTTA TCCTCACTCTGTCCC
TTTTCAATATGCAAG CTTTAAGAACCTTAA CCTCACTCTGTCCCT TTTCAATATGCAAGC
TTTAAGAACCTTAAT CTCACTCTGTCCCTG TTCAATATGCAAGCA TTAAGAACCTTAATG
TCACTCTGTCCCTGT TCAATATGCAAGCAG TAAGAACCTTAATGA CACTCTGTCCCTGTC
CAATATGCAAGCAGC AAGAACCTTAATGAC ACTCTGTCCCTGTCC AATATGCAAGCAGCT
AGAACCTTAATGACA CTCTGTCCCTGTCCT ATATGCAAGCAGCTT GAACCTTAATGACAA
TCTGTCCCTGTCCTT TATGCAAGCAGCTTT AACCTTAATGACAAC CTGTCCCTGTCCTTC
TGTCCCTGTCCTTCC AATAATTGCCACAAG GTCCCTGTGGCCCCA GTCCCTGTCCTTCCC
ATAATTGCCACAAGT TCCCTGTGGCCCCAT TCCCTGTCCTTCCCT TAATTGCCACAAGTC
CCCTGTGGCCCCATC CCCTGTCCTTCCCTG AATTGCCACAAGTCC CCTGTGGCCCCATCC
CCTGTCCTTCCCTGT ATTGCCACAAGTCCA CTGTGGCCCCATCCA CTGTCCTTCCCTGTT
TTGCCACAAGTCCAG TGTGGCCCCATCCAA TGTCCTTCCCTGTTC TGCCACAAGTCCAGC
GTGGCCCCATCCAAC GTCCTTCCCTGTTCT GCCACAAGTCCAGCT TGGCCCCATCCAACC
TCCTTCCCTGTTCTC CCACAAGTCCAGCTG GGCCCCATCCAACCA CCTTCCCTGTTCTCC
CACAAGTCCAGCTGG GCCCCATCCAACCAC CTTCCCTGTTCTCCC ACAAGTCCAGCTGGG
CCCCATCCAACCACT TTCCCTGTTCTCCCT CAAGTCCAGCTGGGA CCCATCCAACCACTG
TCCCTGTTCTCCCTT AAGTCCAGCTGGGAA CCATCCAACCACTGT CCCTGTTCTCCCTTT
AGTCCAGCTGGGAAG CATCCAACCACTGTA CCTGTTCTCCCTTTC GTCCAGCTGGGAAGC
ATCCAACCACTGTAC CTGTTCTCCCTTTCT TCCAGCTGGGAAGCC TCCAACCACTGTACA
TGTTCTCCCTTTCTC CCAGCTGGGAAGCCC CCAACCACTGTACAC GTTCTCCCTTTCTCT
CAGCTGGGAAGCCCT CAACCACTGTACACA TTCTCCCTTTCTCTC AGCTGGGAAGCCCTT
AACCACTGTACACAC TCTCCCTTTCTCTCT GCTGGGAAGCCCTTT ACCACTGTACACACC
CTCCCTTTCTCTCTC CTGGGAAGCCCTTTT CCACTGTACACACCC TCCCTTTCTCTCTCC
TGGGAAGCCCTTTTT CACTGTACACACCCG CCCTTTCTCTCTCCT GGGAAGCCCTTTTTA
ACTGTACACACCCGC
CCTTTCTCTCTCCTC GGAAGCCCTTTTTAT CTGTACACACCCGCC CTTTCTCTCTCCTCT
GAAGCCCTTTTTATC TGTACACACCCGCCT TTTCTCTCTCCTCTC AAGCCCTTTTTATCA
GTACACACCCGCCTG TTCTCTCTCCTCTCT AGCCCTTTTTATCAG TACACACCCGCCTGA
TCTCTCTCCTCTCTG GCCCTTTTTATCAGT ACACACCCGCCTGAC CTCTCTCCTCTCTGC
CCCTTTTTATCAGTT CACACCCGCCTGACA TCTCTCCTCTCTGCT CCTTTTTATCAGTTT
ACACCCGCCTGACAC CTCTCCTCTCTGCTT CTTTTTATCAGTTTG CACCCGCCTGACACC
TCTCCTCTCTGCTTC TTTTTATCAGTTTGA ACCCGCCTGACACCG CTCCTCTCTGCTTCA
TTTTATCAGTTTGAG CCCGCCTGACACCGT TCCTCTCTGCTTCAT TTTATCAGTTTGAGG
CCGCCTGACACCGTG CCTCTCTGCTTCATA TTATCAGTTTGAGGA CGCCTGACACCGTGG
CTCTCTGCTTCATAA TATCAGTTTGAGGAA GCCTGACACCGTGGG TCTCTGCTTCATAAC
ATCAGTTTGAGGAAG CCTGACACCGTGGGT CTCTGCTTCATAACG TCAGTTTGAGGAAGT
CTGACACCGTGGGTC TCTGCTTCATAACGG CAGTTTGAGGAAGTG TGACACCGTGGGTCA
CTGCTTCATAACGGA AGTTTGAGGAAGTGG GACACCGTGGGTCAT TGCTTCATAACGGAA
GTTTGAGGAAGTGGC ACACCGTGGGTCATT GCTTCATAACGGAAA TTTGAGGAAGTGGCT
CACCGTGGGTCATTA CTTCATAACGGAAAA TTGAGGAAGTGGCTG ACCGTGGGTCATTAC
TTCATAACGGAAAAA TGAGGAAGTGGCTGT CCGTGGGTCATTACA TCATAACGGAAAAAT
GAGGAAGTGGCTGTC CGTGGGTCATTACAA CATAACGGAAAAATA AGGAAGTGGCTGTCC
GTGGGTCATTACAAA ATAACGGAAAAATAA GGAAGTGGCTGTCCC TGGGTCATTACAAAA
TAACGGAAAAATAAT GAAGTGGCTGTCCCT GGGTCATTACAAAAA AACGGAAAAATAATT
AAGTGGCTGTCCCTG GGTCATTACAAAAAA ACGGAAAAATAATTG AGTGGCTGTCCCTGT
GTCATTACAAAAAAA CGGAAAAATAATTGC GTGGCTGTCCCTGTG TCATTACAAAAAAAC
GGAAAAATAATTGCC TGGCTGTCCCTGTGG CATTACAAAAAAACA GAAAAATAATTGCCA
GGCTGTCCCTGTGGC ATTACAAAAAAACAC AAAAATAATTGCCAC GCTGTCCCTGTGGCC
TTACAAAAAAACACG AAAATAATTGCCACA CTGTCCCTGTGGCCC TACAAAAAAACACGT
AAATAATTGCCACAA TGTCCCTGTGGCCCC ACAAAAAAACACGTG CAAAAAAACACGTGG
ATGAAATTTACAAAG TAATTTTGCCAAAAT AAAAAAACACGTGGA TGAAATTTACAAAGG
AATTTTGCCAAAATC AAAAAACACGTGGAG GAAATTTACAAAGGG ATTTTGCCAAAATCC
AAAAACACGTGGAGA AAATTTACAAAGGGC TTTTGCCAAAATCCT AAAACACGTGGAGAT
AATTTACAAAGGGCC TTTGCCAAAATCCTG AAACACGTGGAGATG ATTTACAAAGGGCCA
TTGCCAAAATCCTGA AACACGTGGAGATGG TTTACAAAGGGCCAT TGCCAAAATCCTGAA
ACACGTGGAGATGGA TTACAAAGGGCCATC GCCAAAATCCTGAAC CACGTGGAGATGGAA
TACAAAGGGCCATCG CCAAAATCCTGAACT ACGTGGAGATGGAAA ACAAAGGGCCATCGT
CAAAATCCTGAACTT CGTGGAGATGGAAAT CAAAGGGCCATCGTT AAAATCCTGAACTTT
GTGGAGATGGAAATT AAAGGGCCATCGTTC AAATCCTGAACTTTC TGGAGATGGAAATTT
AAGGGCCATCGTTCA AATCCTGAACTTTCT GGAGATGGAAATTTT AGGGCCATCGTTCAT
ATCCTGAACTTTCTC GAGATGGAAATTTTT GGGCCATCGTTCATC TCCTGAACTTTCTCC
AGATGGAAATTTTTA GGCCATCGTTCATCC CCTGAACTTTCTCCC GATGGAAATTTTTAC
GCCATCGTTCATCCA CTGAACTTTCTCCCT ATGGAAATTTTTACC CCATCGTTCATCCAA
TGAACTTTCTCCCTC TGGAAATTTTTACCT CATCGTTCATCCAAG GAACTTTCTCCCTCA
GGAAATTTTTACCTT ATCGTTCATCCAAGG AACTTTCTCCCTCAT GAAATTTTTACCTTT
TCGTTCATCCAAGGC ACTTTCTCCCTCATC AAATTTTTACCTTTA CGTTCATCCAAGGCT
CTTTCTCCCTCATCG AATTTTTACCTTTAT GTTCATCCAAGGCTG TTTCTCCCTCATCGG
ATTTTTACCTTTATC TTCATCCAAGGCTGT TTCTCCCTCATCGGC TTTTTACCTTTATCT
TCATCCAAGGCTGTT TCTCCCTCATCGGCC TTTTACCTTTATCTT CATCCAAGGCTGTTA
CTCCCTCATCGGCCC TTTACCTTTATCTTT ATCCAAGGCTGTTAC TCCCTCATCGGCCCG
TTACCTTTATCTTTC TCCAAGGCTGTTACC CCCTCATCGGCCCGG TACCTTTATCTTTCA
CCAAGGCTGTTACCA CCTCATCGGCCCGGC ACCTTTATCTTTCAC CAAGGCTGTTACCAT
CTCATCGGCCCGGCG CCTTTATCTTTCACC AAGGCTGTTACCATT TCATCGGCCCGGCGC
CTTTATCTTTCACCT AGGCTGTTACCATTT CATCGGCCCGGCGCT TTTATCTTTCACCTT
GGCTGTTACCATTTT ATCGGCCCGGCGCTG TTATCTTTCACCTTT GCTGTTACCATTTTA
TCGGCCCGGCGCTGA TATCTTTCACCTTTC CTGTTACCATTTTAA CGGCCCGGCGCTGAT
ATCTTTCACCTTTCT TGTTACCATTTTAAC GGCCCGGCGCTGATT TCTTTCACCTTTCTA
GTTACCATTTTAACG GCCCGGCGCTGATTC CTTTCACCTTTCTAG TTACCATTTTAACGC
CCCGGCGCTGATTCC TTTCACCTTTCTAGG TACCATTTTAACGCT CCGGCGCTGATTCCT
TTCACCTTTCTAGGG ACCATTTTAACGCTG CGGCGCTGATTCCTC TCACCTTTCTAGGGA
CCATTTTAACGCTGC GGCGCTGATTCCTCG CACCTTTCTAGGGAC CATTTTAACGCTGCC
GCGCTGATTCCTCGT ACCTTTCTAGGGACA ATTTTAACGCTGCCT CGCTGATTCCTCGTG
CCTTTCTAGGGACAT TTTTAACGCTGCCTA GCTGATTCCTCGTGT CTTTCTAGGGACATG
TTTAACGCTGCCTAA CTGATTCCTCGTGTC TTTCTAGGGACATGA TTAACGCTGCCTAAT
TGATTCCTCGTGTCC TTCTAGGGACATGAA TAACGCTGCCTAATT GATTCCTCGTGTCCG
TCTAGGGACATGAAA AACGCTGCCTAATTT ATTCCTCGTGTCCGG CTAGGGACATGAAAT
ACGCTGCCTAATTTT TTCCTCGTGTCCGGA TAGGGACATGAAATT CCCTGCCTAATTTTG
TCCTCGTGTCCGGAG AGGGACATGAAATTT GCTGCCTAATTTTGC CCTCGTGTCCGGAGG
GGGACATGAAATTTA CTGCCTAATTTTGCC CTCGTGTCCGGAGGC GGACATGAAATTTAC
TGCCTAATTTTGCCA TCGTGTCCGGAGGCA GACATGAAATTTACA GCCTAATTTTGCCAA
CGTGTCCGGAGGCAT ACATGAAATTTACAA CCTAATTTTGCCAAA GTGTCCGGAGGCATG
CATGAAATTTACAAA CTAATTTTGCCAAAA TGTCCGGAGGCATGG GTCCGGAGGCATGGG
CGACACACTCCGTCC CAGGTCTCATTGCTT TCCGGAGGCATGGGT GACACACTCCGTCCA
AGGTCTCATTGCTTC CCGGAGGCATGGGTG ACACACTCCGTCCAT GGTCTCATTGCTTCT
CGGAGGCATGGGTGA CACACTCCGTCCATC GTCTCATTGCTTCTG GGAGGCATGGGTGAG
ACACTCCGTCCATCC TCTCATTGCTTCTGA GAGGCATGGGTGAGC CACTCCGTCCATCCG
CTCATTGCTTCTGAC AGGCATGGGTGAGCA ACTCCGTCCATCCGA TCATTGCTTCTGACT
GGCATGGGTGAGCAT CTCCGTCCATCCGAC CATTGCTTCTGACTA GCATGGGTGAGCATG
TCCGTCCATCCGACT ATTGCTTCTGACTAG CATGGGTGAGCATGG CCGTCCATCCGACTG
TTGCTTCTGACTAGA ATGGGTGAGCATGGC CGTCCATCCGACTGC TGCTTCTGACTAGAT
TGGGTGAGCATGGCA GTCCATCCGACTGCC GCTTCTGACTAGATT GGGTGAGCATGGCAG
TCCATCCGACTGCCC CTTCTGACTAGATTA GGTGAGCATGGCAGC CCATCCGACTGCCCC
TTCTGACTAGATTAT GTGAGCATGGCAGCT CATCCGACTGCCCCT TCTGACTAGATTATT
TGAGCATGGCAGCTG ATCCGACTGCCCCTG CTGACTAGATTATTA GAGCATGGCAGCTGG
TCCGACTGCCCCTGC TGACTAGATTATTAT AGCATGGCAGCTGGT CCGACTGCCCCTGCT
GACTAGATTATTATT GCATGGCAGCTGGTT CGACTGCCCCTGCTG ACTAGATTATTATTT
CATGGCAGCTGGTTG GACTGCCCCTGCTGT CTAGATTATTATTTG ATGGCAGCTGGTTGC
ACTGCCCCTGCTGTG TAGATTATTATTTGG TGGCAGCTGGTTGCT CTGCCCCTGCTGTGC
AGATTATTATTTGGG GGCAGCTGGTTGCTC TGCCCCTGCTGTGCT GATTATTATTTGGGG
GCAGCTGGTTGCTCC GCCCCTGCTGTGCTG ATTATTATTTGGGGG CAGCTGGTTGCTCCA
CCCCTGCTGTGCTGC TTATTATTTGGGGGA AGCTGGTTGCTCCAT CCCTGCTGTGCTGCT
TATTATTTGGGGGAA GCTGGTTGCTCCATT CCTGCTGTGCTGCTC ATTATTTGGGGGAAC
CTGGTTGCTCCATTT CTGCTGTGCTGCTCA TTATTTGGGGGAACT TGGTTGCTCCATTTG
TGCTGTGCTGCTCAA TATTTGGGGGAACTG GGTTGCTCCATTTGA GCTGTGCTGCTCAAG
ATTTGGGGGAACTGG GTTGCTCCATTTGAG CTGTGCTGCTCAAGG TTTGGGGGAACTGGA
TTGCTCCATTTGAGA TGTGCTGCTCAAGGC TTGGGGGAACTGGAC TGCTCCATTTGAGAG
GTGCTGCTCAAGGCC TGGGGGAACTGGACA GCTCCATTTGAGAGA TGCTGCTCAAGGCCA
GGGGGAACTGGACAC CTCCATTTGAGAGAC GCTGCTCAAGGCCAC GGGGAACTGGACACA
TCCATTTGAGAGACA CTGCTCAAGGCCACA GGGAACTGGACACAA CCATTTGAGAGACAC
TGCTCAAGGCCACAG GGAACTGGACACAAT CATTTGAGAGACACG GCTCAAGGCCACAGG
GAACTGGACACAATA ATTTGAGAGACACGC CTCAAGGCCACAGGC AACTGGACACAATAG
TTTGAGAGACACGCT TCAAGGCCACAGGCA ACTGGACACAATAGG TTGAGAGACACGCTG
CAAGGCCACAGGCAC CTGGACACAATAGGT TGAGAGACACGCTGG AAGGCCACAGGCACA
TGGACACAATAGGTC GAGAGACACGCTGGC AGGCCACAGGCACAC GGACACAATAGGTCT
AGAGACACGCTGGCG GGCCACAGGCACACA GACACAATAGGTCTT GAGACACGCTGGCGA
GCCACAGGCACACAG ACACAATAGGTCTTT AGACACGCTGGCGAC CCACAGGCACACAGG
CACAATAGGTCTTTC GACACGCTGGCGACA CACAGGCACACAGGT ACAATAGGTCTTTCT
ACACGCTGGCGACAC ACAGGCACACAGGTC CAATAGGTCTTTCTC CACGCTGGCGACACA
CAGGCACACAGGTCT AATAGGTCTTTCTCT ACGCTGGCGACACAC AGGCACACAGGTCTC
ATAGGTCTTTCTCTC CGCTGGCGACACACT GGCACACAGGTCTCA TAGGTCTTTCTCTCA
GCTGGCGACACACTC GCACACAGGTCTCAT AGGTCTTTCTCTCAG CTGGCGACACACTCC
CACACAGGTCTCATT GGTCTTTCTCTCAGT TGGCGACACACTCCG ACACAGGTCTCATTG
GTCTTTCTCTCAGTG GGCGACACACTCCGT CACAGGTCTCATTGC TCTTTCTCTCAGTGA
GCGACACACTCCGTC ACAGGTCTCATTGCT CTTTCTCTCAGTGAA TTTCTCTCAGTGAAG
TTCTCTCAGTGAAGG TCTCTCAGTGAAGGT CTCTCAGTGAAGGTG TCTCAGTGAAGGTGG
CTCAGTGAAGGTGGG TCAGTGAAGGTGGGG CAGTGAAGGTGGGGA AGTGAAGGTGGGGAG
GTGAAGGTGGGGAGA TGAAGGTGGGGAGAA GAAGGTGGGGAGAAG AAGGTGGGGAGAAGC
AGGTGGGGAGAAGCT GGTGGGGAGAAGCTG GTGGGGAGAAGCTGA TGGGGAGAAGCTGAA
GGGGAGAAGCTGAAC GGGAGAAGCTGAACC GGAGAAGCTGAACCG GAGAAGCTGAACCGG
AGAAGCTGAACCGGC
EXAMPLE 9
Inhibition of IGF-I Binding by Antisense Oligonucleotides to IGf-I
Receptor
[0059] Sub-confluent HaCaT cells were treated as described above
with phosphorothioate oligonucleotides IGFR.AS (antisense:
5'-ATCTCTCCGCTTCCTTT-3'; [SEQ ID NO. 10]; ref 13) and IGFR.S (sense
control: 5'-GAAAGGAAGCGGAGAGAT-3'; [SEQ ID NO. 11]; Ref 13) IGF-I
binding to the cell monolayers was then measured as
.sup.125I-IGF-I.
EXAMPLE 10
Inhibition of IGFBP-3 Production Using Antisense
Oligonucleotides
[0060] The results of this experiment are shown in FIGS. 7 and
8.
[0061] HaCaT cells were initially plated in DMEM with 10% v/v
serum, then AS oligo experiments were performed in complete
"Keratinocyte-SFM" (Gibco) to exclude the influence of exogenous
IGFBPs. Oligos were synthesised as phosphorothioate
(nuclease-resistant) derivatives (Bresatec, South Australia) and
were as follows: antisense: AS2, 5'-GCGCCCGCTGCATGACGCCTCAAC-3'
(IGFBP-3 start codon); control AS2NS,
5'-CGGAGATGCCGCATGCCAGCGCAGG-3'; AS4, 5'-AGGCGGCTGACGGCACTA-3';
AS4NS, 5'-GACAGCGTCGGAGCGATC-3'; IGFRAS, 5'-ATCTCTCCGCTTCCTTTC-3';
IGFRS, 5'-GAAAGGAAGCGGAGAGAT-3'. Oligos to IGFBP-3 were based on
the published sequence of Spratt et al [12]. AS oligos were added
to HaCaT monolayers in 0.5 ml medium in 24-well plates at the
concentrations and addition frequencies indicated. IGFBP-3 measured
in cell-conditioned medium using a dot-blot assay, adapted from the
Western ligand blot method of Hossenlopp et al [11], in which 100
.mu.l of conditioned medium was applied to nitrocellulose filters
with a vacuum dot-blot apparatus. After drying the membranes at
37.degree. C., relative amounts of IGFBP are determined by
.sup.125I-IGF-I-binding, autoradiography and computerised imaging
densitometry. Triplicate wells (except in FIG. 7, where duplicate
wells were measured as shown) were analysed and corrected for
changes in cell number per well. Relative cell number per well was
determined using an amido black dye method, developed specifically
for cultured monolayers of HaCaT cells (14). Cell numbers differed
by less than 10% after treatment. For oligos to the IGF receptor,
receptor quantitation in intact HaCaT monolayers was by overnight
incubation with .sup.125I-IGF-I (30,000 cpm/well) at 4.degree.
C.
EXAMPLE11
Inhibition of IGFBP-2 Production Using Ribozymes
[0062] Experiments involving ribozymes are generally conducted as
described in Internaitonal Patent Application No. WO 89/05852 and
in Haselhoff and Gerlach [8]. Ribozymes are constructed with a
hybridising region which is complementary in nucleotide sequence to
at least part of a target RNA which, in this case, encodes IGFBP-2.
Activity of ribozymes is measurable on, for example, Northern blots
or using animal models such as in the nude mouse model (15; 16) or
the "flaky skin" mouse model (17; 18).
EXAMPLE 12
Inhibition of IGFBP-3 Production Using Ribozymes
[0063] The methods described in Example 11 are used for the
screening of ribozymes which inhibit IGFBP-3 production. The
activity of the ribozymes is determined as in Example 11.
EXAMPLE 13
Inhibition of IGF-1 Production Using Ribozymes
[0064] The methods described in Example 11 are used for the
screening of ribozymes which inhibit IGF-1 production. The activity
of the ribozymes is determined as in Example 11.
EXAMPLE 14
Inhibition of IGF-1 Receptor Production Using Ribozymes
[0065] The methods described in Example 11 are used for the
screening of ribozymes which inhibit IGF-1 production. The activity
of the ribozymes is determined as in Example 11
[0066] Those skilled in the art will appreciate that the invention
described herein is susceptible to variations and modifications
other than those specifically described. It is to be understood
that the invention includes all such variations and modifications.
The invention also includes all of the steps, features,
compositions and compounds referred to or indicated in this
specification, individually or collectively, and any and all
combinations of any two or more of said steps or features.
[0067] References:
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Sequence CWU 0
0
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