U.S. patent application number 10/205522 was filed with the patent office on 2003-04-24 for genotyping human udp-glucuronsyltransferase 2b15 (ugt2b15) genes. This patent application is currently assigned to DNA Sciences, Inc.. Invention is credited to Galvin, Margaret, Miller, Andrew, Penny, Laura, Riedy, Michael.
Application Number | 20030077629 10/205522 |
Document ID | / |
Family ID | 22244887 |
Filed Date | 2003-04-24 |
United States Patent Application | 20030077629 |
Kind Code | A1 |
Galvin, Margaret ; et al. | April 24, 2003 |
Genetic polymorphisms are identified in the human UGT2B4, UGT2B7 and UGT2B15 genes that alter UGT2B activity. Nucleic acids comprising the polymorphic sequences are used to screen patients for altered metabolism for UGT2B substrates, potential drug-drug interactions, and adverse/side effects, as well as diseases that result from environmental or occupational exposure to toxins. The nucleic acids are used to establish animal, cell and in vitro models for drug metabolism.
Inventors: | Galvin, Margaret; (San Diego, CA) ; Miller, Andrew; (San Mateo, CA) ; Penny, Laura; (San Diego, CA) ; Riedy, Michael; (San Diego, CA) |
Correspondence Address: |
SHERIDAN ROSS PC 1560 BROADWAY SUITE 1200 DENVER CO 80202 |
Assignee: | DNA Sciences, Inc. |
Family ID: | 22244887 |
Appl. No.: | 10/205522 |
Filed: | July 24, 2002 |
Application Number | Filing Date | Patent Number | ||
---|---|---|---|---|
10205522 | Jul 24, 2002 | |||
09356806 | Jul 20, 1999 | |||
60094391 | Jul 28, 1998 | |||
Current U.S. Class: | 435/6.16 ; 536/24.3 |
Current CPC Class: | C12Q 1/6883 20130101; C12Q 2600/156 20130101 |
Class at Publication: | 435/6 ; 536/24.3 |
International Class: | C12Q 001/68; C07H 021/04 |
Sequence CWU 1
1
164 1 1323 DNA H. sapiens Other (140)...(897) 1 tcatctacct
tttagttgtc tctttgtcat ccacatgctc agactgttaa tataatgtat 60
ttactttgaa gtgtaaaagt tacattttaa cttcttgact gatttatact ggatgtcacc
120 atgagaaatg acagaaagga gcagcaactg gaaaacaagc attgcattgc
atcaggatgt 180 ctatgaaatg gacttcagct cttctgctga tacagctgag
ctgttacttt agctctggga 240 gttgtggaaa ggtgctggtg tggcccacag
aattcagcca ctggatgaat ataaagacaa 300 tcctggatga acttgtccag
agaggtcatg aggtgactgt attggcatct tcagcttcca 360 tttctttcga
tcccaacagc ccatctactc ttaaatttga agtttatcct gtatctttaa 420
ctaaaactga gtttgaggat attatcaagc agctggttaa gagatgggca gaacttccaa
480 aagacacatt ttggtcatat ttttcacaag tacaagaaat catgtggaca
tttaatgaca 540 tacttagaaa gttctgtaag gatatagttt caaataagaa
acttatgaag aaactacagg 600 agtcaagatt tgatgttgtt cttgcagatg
ctgttttccc ctttggtgag ctgctggccg 660 agttacttaa aatacccttt
gtctacagcc tccgcttctc tcctggctac gcaattgaaa 720 agcatagtgg
aggacttctg ttccctcctt cctatgtgcc tgttgttatg tcagaactaa 780
gtgaccaaat gactttcata gagagggtaa aaaatatgat ctatgtgctt tattttgaat
840 tttggttcca aatatttgac atgaagaagt gggatcagtt ctacagtgaa
gttctaggta 900 agtaactttt ttgattggta acatgaagat ctaactttct
tgtacctttg aagctgagtt 960 tgtataaagc cataaagtca gggtagtggg
gtatttttgt aatgaattta tcaaatgaaa 1020 ttgtaagatg atctaccaaa
ctcacaagca ctatagaaaa tgtaaattat aggatcagtt 1080 aaaactctgt
ggccatcact catacagaag actccaggaa gtcataagcc tgtatattag 1140
tgcacctaag atttctttaa gcaatcacat atctgtttta ttatacattt tttcatctta
1200 aaaaaaagtc agacttattc agaaacatct tgctgaatgc atactggtag
attgagtagt 1260 tacacatttt ttagaactat ctatataaca ttgcagaaat
tgttttttct tgtatatttg 1320 cag 1323 2 746 DNA H. sapiens Other
(195)...(344) 2 ttcttgtaaa tacacatggg taaaatatat aatacataaa
aattaaatta tgcctatata 60 cgaatatatg tatttttttt caaggcacaa
acactttgcc tacatttttg cccacattat 120 tctaacttct ttcagaaaat
tacctagttt aattatcttg tgtcatctat cttttctttt 180 tttttccccc
atcaggaaga cccactacgt tatctgagac aatggcaaaa gctgacatat 240
ggcttattcg aaactactgg gattttcaat ttcctcaccc actcttacca aatgttgagt
300 tcgttggagg actccactgc aaacctgcca aacccctacc gaaggtaaac
tattactgtt 360 tgttttgtct gctttgaagt ttcagtacga atggttctat
attcattcaa agtgtttgac 420 ttacactgga agaaaggtgg aagtgggaag
agtaaagcag ataccaatta gaaactgacg 480 tacatgttga tactatcaca
agtttatgaa tttcatcatt attaccaata aagagggata 540 ctaaagagac
tttgaaaata gggttggtaa attaaagctt tgattatgca acatataaga 600
aggtactggc cattcattca aagaatattt ataaagagat tagcacacac cacaggtacg
660 tgtatgggac acagtttcta tcccaacaca ccttacattc tattttgaaa
gatagaatat 720 atgcaagtaa taaaaactgt gtaaaa 746 3 785 DNA H.
sapiens Other (238)...(369) 3 ttcacaaacg cacacacata cacacacaca
tatttacaca aagaccctta acagaggcaa 60 cctatctcat attatacata
ttgcaaaaaa aactgagtaa ttgagtcagt taaaaaacat 120 cctttactcc
aataattcct gataaaactt gattttctct ctttttataa caattctttc 180
acagtgcttg ctgtgctgat aatctattat gatagaacaa attctttttt ttcacaggaa
240 atggaagagt ttgtccagag ctctggagaa aatggtgttg tggtgttttc
tctggggtcg 300 atggtcagta acacgtcaga agaaagggcc aatgtaattg
catcagccct tgccaagatc 360 ccacaaaagg taagataaaa tgttttaatg
gtgtaaaaaa ctactgaaag aggctgttaa 420 agtttgtaaa gaacccaatt
gtagaaactt cctgcctata tattcagctg ttgggaaagc 480 actaattatc
tcagatatta attcaaaatc aaaaatatgt atggaagatg ataaactcat 540
acagaaggtg tttttcattg gtaattaatt tggcattaat attgtgatca ggaataaata
600 caattaagag ttgcaggtaa agttttggta ttatcatgat actggggtca
ggtaagagct 660 atcaccaaat tctgcccctg tgatttgatc cttttgttta
agaactcctg agggcgatgt 720 acatcctaca ggtgttagaa aacgttacat
tttaatgagt aacttcacta gcacaataac 780 aatag 785 4 1138 DNA H.
sapiens Other (395)...(482) 4 catctgttat tttttgagtt tttaataatg
gccattctga ctggtgtgag atggtatctc 60 tttgtggatt taaccagtga
tgtaaacctt tttttcatat agtggtttgc cacatatagt 120 tttcttttga
aaagtgtaac aactttttaa atacttgaac ttttcattga ttatcttatt 180
tgtctaagct actattttga aaaatcatga tttccttata tacctaatta tgaaattaag
240 gaaatgaaat atgagtattc tatttacatc agtctgagta gttcttgtta
cttaacatcc 300 cttgttcttc tcattgttaa tctctttaga tttctaacat
tctatgactt ttgagttcca 360 ctcatggaat aagatatttt cttcactgta
acaggttctg tggagatttg atgggaataa 420 accagatact ttaggactca
atactcggct gtacaagtgg ataccccaga atgatcttct 480 tggtaagtct
ctgaagaaca aatactgaat atattagtaa cagattatta aagtgttaat 540
agctatcatg aaacaagctt actgaacatt tgttatggaa aaacttaaaa ataaaatgaa
600 acttctttat atttattttc cagtcccggg ggaaaagaat aaattgttgg
cattttatga 660 tatgcaccca cattctttac aatcagagtc agagtatctt
tatttcaggt gttattacct 720 cccacagaat ttttctggca cttcctgggt
tgtcttcctt tctcatattt ctacaacttt 780 acacctgttc tttcctcctc
tgtagggtta tttcaaatgt cactaaaagt aacagctctt 840 ctgctatcac
cagggatgct gcattttctg taggattaaa tccctaatct taatcaaaaa 900
gtgatgacac atttcataat gaaatgtgac ctgtctttcc tcaattctag caccaccacc
960 acctcactgc ctgctgcctt gcacacccta catatccaac tccgtgactg
tacttaagag 1020 aacacattct ggctgggcac ggtgctcacg cctgcaatcc
tagcactttg ggaggctgat 1080 ggcaggtgga ttgactgagc tcaggagttc
aagaccatcc tgggcaacat ggtgaaac 1138 5 689 DNA H. sapiens Other
(123)...(342) 5 aaaaacaatt ttaattcagt tcagtgtgtt atctaggaaa
caccgtcaca ttcagattct 60 tccattgtgc atttctcatt ttattcctat
gaataatttt gctaaaattc atccaatcct 120 aggtcaccca aaaaccagag
cttttataac tcatggtgga gccaatggca tctatgaggc 180 aatctaccat
ggaatcccta tggtgggcgt tccattgttt gcagatcaac ctgataacat 240
tgcacacatg aaggccaagg gagcagctgt tagtttggac ttccacacaa tgtcgagtac
300 agacttactc aatgcactga agacagtaat taatgatcct ttgtgagtat
aacttttttt 360 ttactcggtg gtctttatag ataggttccc ttgtgaatag
tgagtatgac ttttatcctt 420 tttataagcg actgatttcg aaagaattta
agtgatttaa acaatctgaa atctgctttt 480 atttttgagt ggttatttaa
aaattttatt tgaaccacat acatttaatg aataatcaat 540 tattgaaata
attttctaca caaaaataat tttaaagtga tatagataag aagacatttt 600
aaaataaatt tgacgtaatc aatccacagt agaaaggaaa gataaacttg acgtaatata
660 ataaaatatt ttaattcaat atctaaaat 689 6 1589 DNA H. sapiens Other
(731)...(1475) 6 atgcttaagc aatgggtagc ctttcttcat gatgtgatta
tttcacactg cagcctgtat 60 caaaacatct catgcacctc atagaaaaat
acccctacta tgtaaccaca aaaactaaaa 120 attaaaagaa aataaaattg
ctcatatgtt ctctgcctca aataattaac tttctcacct 180 gaccctccat
ttttacttta aaaatatttg tcaattatga aattccaatt taaaagccaa 240
actttctatg atgactcaaa ttaaaataca cacattctat gtcaattcta tgacatttac
300 tttgaatgat ctggcacttt aaaaaccttt cgtggacttg atgtgctcag
gcaaattaac 360 ttaccttctc tttttttgag agggaagtct cactctgtca
ccaggctgga gtgcagtggt 420 gtgattgtgg ctcactgcaa cttccgcctc
ttgggttcaa gcgattctcc tgcctcagcc 480 tctcaagtag ctgggactac
aggcacatgc caccacgcct gggtaatctt tttttttttt 540 ttttttttca
tatttttact ggagacgggg tgaacggggt ttcaccgtgt tagccaggat 600
ggtcttgatc tcctgacctc gtgatccgcc cgcctcgacc tcggaaagtg ctgggattgc
660 aggtgtgagc ctccgtgcct ggccaaattg acttactttc aatgttgata
cttttctgct 720 tatcgtttag atataaagag aatgctatga aattatcaag
aattcatcat gatcaaccag 780 tgaagcccct tgatcgagca gtcttctgga
ttgaatttgt catgcgccat aaaggagcca 840 agcaccttcg ggttgcagcc
cacgacctca cctggttcca gtaccactct ttggatgtga 900 ctgggttcct
gctggcctgt gtggcaactg tgatattcat catcacaaaa tgtctgtttt 960
gtgtctggaa gtttgttaga acaggaaaga aggggaaaag agattaatta cgtctgaggc
1020 tggaagctgg gaaacccaat aaatgaactc ctttagttta ttacaacaag
aagacgttgt 1080 gatacaagag attcctttct tcttgtgaca aaacatcttt
caaaacttac cttgtcaagt 1140 caaaatttgt tttagtacct gtttaaccat
tagaaatatt tcatgtcaag gaggaaaaca 1200 ttagggaaaa caaaaatgat
ataaagccat acgaggttat attgaaatgt attgagctta 1260 tattgaaatt
tattgttcca attcacaggt tacatgaaaa aaaatttact aagcttaact 1320
acatgtcaca cattgtacat ggaaacaaga acattaagaa gtccactgac agtatcagta
1380 ctgttttgca aatactcagc atactttgga tccatttcat gcaggattgt
gttgttttaa 1440 ctgttgttga ggaaactaat aaataattaa attgtataga
aagtctcttc ctcttgatat 1500 tttgagatga ttagtgctgc ttggctttta
ttgtgcatcg tgcttcaacg tcattttttt 1560 tcctaaaagg tatgataaaa
aatgcttac 1589 7 2092 DNA H. sapiens CDS (38)...(1621) 7 agcagcaact
ggaaaacaag cattgcattg catcagg atg tct atg aaa tgg act 55 Met Ser
Met Lys Trp Thr 1 5 tca gct ctt ctg ctg ata cag ctg agc tgt tac ttt
agc tct ggg agt 103 Ser Ala Leu Leu Leu Ile Gln Leu Ser Cys Tyr Phe
Ser Ser Gly Ser 10 15 20 tgt gga aag gtg ctg gtg tgg ccc aca gaa
ttc agc cac tgg atg aat 151 Cys Gly Lys Val Leu Val Trp Pro Thr Glu
Phe Ser His Trp Met Asn 25 30 35 ata aag aca atc ctg gat gaa ctt
gtc cag aga ggt cat gag gtg act 199 Ile Lys Thr Ile Leu Asp Glu Leu
Val Gln Arg Gly His Glu Val Thr 40 45 50 gta ttg gca tct tca gct
tcc att tct ttc gat ccc aac agc cca tct 247 Val Leu Ala Ser Ser Ala
Ser Ile Ser Phe Asp Pro Asn Ser Pro Ser 55 60 65 70 act ctt aaa ttt
gaa gtt tat cct gta tct tta act aaa act gag ttt 295 Thr Leu Lys Phe
Glu Val Tyr Pro Val Ser Leu Thr Lys Thr Glu Phe 75 80 85 gag gat
att atc aag cag ctg gtt aag aga tgg gca gaa ctt cca aaa 343 Glu Asp
Ile Ile Lys Gln Leu Val Lys Arg Trp Ala Glu Leu Pro Lys 90 95 100
gac aca ttt tgg tca tat ttt tca caa gta caa gaa atc atg tgg aca 391
Asp Thr Phe Trp Ser Tyr Phe Ser Gln Val Gln Glu Ile Met Trp Thr 105
110 115 ttt aat gac ata ctt aga aag ttc tgt aag gat ata gtt tca aat
aag 439 Phe Asn Asp Ile Leu Arg Lys Phe Cys Lys Asp Ile Val Ser Asn
Lys 120 125 130 aaa ctt atg aag aaa cta cag gag tca aga ttt gat gtt
gtt ctt gca 487 Lys Leu Met Lys Lys Leu Gln Glu Ser Arg Phe Asp Val
Val Leu Ala 135 140 145 150 gat gct gtt ttc ccc ttt ggt gag ctg ctg
gcc gag tta ctt aaa ata 535 Asp Ala Val Phe Pro Phe Gly Glu Leu Leu
Ala Glu Leu Leu Lys Ile 155 160 165 ccc ttt gtc tac agc ctc cgc ttc
tct cct ggc tac gca att gaa aag 583 Pro Phe Val Tyr Ser Leu Arg Phe
Ser Pro Gly Tyr Ala Ile Glu Lys 170 175 180 cat agt gga gga ctt ctg
ttc cct cct tcc tat gtg cct gtt gtt atg 631 His Ser Gly Gly Leu Leu
Phe Pro Pro Ser Tyr Val Pro Val Val Met 185 190 195 tca gaa cta agt
gac caa atg act ttc ata gag agg gta aaa aat atg 679 Ser Glu Leu Ser
Asp Gln Met Thr Phe Ile Glu Arg Val Lys Asn Met 200 205 210 atc tat
gtg ctt tat ttt gaa ttt tgg ttc caa ata ttt gac atg aag 727 Ile Tyr
Val Leu Tyr Phe Glu Phe Trp Phe Gln Ile Phe Asp Met Lys 215 220 225
230 aag tgg gat cag ttc tac agt gaa gtt cta gga aga ccc act acg tta
775 Lys Trp Asp Gln Phe Tyr Ser Glu Val Leu Gly Arg Pro Thr Thr Leu
235 240 245 tct gag aca atg gca aaa gct gac ata tgg ctt att cga aac
tac tgg 823 Ser Glu Thr Met Ala Lys Ala Asp Ile Trp Leu Ile Arg Asn
Tyr Trp 250 255 260 gat ttt caa ttt cct cac cca ctc tta cca aat gtt
gag ttc gtt gga 871 Asp Phe Gln Phe Pro His Pro Leu Leu Pro Asn Val
Glu Phe Val Gly 265 270 275 gga ctc cac tgc aaa cct gcc aaa ccc cta
ccg aag gaa atg gaa gag 919 Gly Leu His Cys Lys Pro Ala Lys Pro Leu
Pro Lys Glu Met Glu Glu 280 285 290 ttt gtc cag agc tct gga gaa aat
ggt gtt gtg gtg ttt tct ctg ggg 967 Phe Val Gln Ser Ser Gly Glu Asn
Gly Val Val Val Phe Ser Leu Gly 295 300 305 310 tcg atg gtc agt aac
acg tca gaa gaa agg gcc aat gta att gca tca 1015 Ser Met Val Ser
Asn Thr Ser Glu Glu Arg Ala Asn Val Ile Ala Ser 315 320 325 gcc ctt
gcc aag atc cca caa aag gtt ctg tgg aga ttt gat ggg aat 1063 Ala
Leu Ala Lys Ile Pro Gln Lys Val Leu Trp Arg Phe Asp Gly Asn 330 335
340 aaa cca gat act tta gga ctc aat act cgg ctg tac aag tgg ata ccc
1111 Lys Pro Asp Thr Leu Gly Leu Asn Thr Arg Leu Tyr Lys Trp Ile
Pro 345 350 355 cag aat gat ctt ctt ggt cac cca aaa acc aga gct ttt
ata act cat 1159 Gln Asn Asp Leu Leu Gly His Pro Lys Thr Arg Ala
Phe Ile Thr His 360 365 370 ggt gga gcc aat ggc atc tat gag gca atc
tac cat gga atc cct atg 1207 Gly Gly Ala Asn Gly Ile Tyr Glu Ala
Ile Tyr His Gly Ile Pro Met 375 380 385 390 gtg ggc gtt cca ttg ttt
gca gat caa cct gat aac att gca cac atg 1255 Val Gly Val Pro Leu
Phe Ala Asp Gln Pro Asp Asn Ile Ala His Met 395 400 405 aag gcc aag
gga gca gct gtt agt ttg gac ttc cac aca atg tcg agt 1303 Lys Ala
Lys Gly Ala Ala Val Ser Leu Asp Phe His Thr Met Ser Ser 410 415 420
aca gac tta ctc aat gca ctg aag aca gta att aat gat cct tta tat
1351 Thr Asp Leu Leu Asn Ala Leu Lys Thr Val Ile Asn Asp Pro Leu
Tyr 425 430 435 aaa gag aat gct atg aaa tta tca aga att cat cat gat
caa cca gtg 1399 Lys Glu Asn Ala Met Lys Leu Ser Arg Ile His His
Asp Gln Pro Val 440 445 450 aag ccc ctt gat cga gca gtc ttc tgg att
gaa ttt gtc atg cgc cat 1447 Lys Pro Leu Asp Arg Ala Val Phe Trp
Ile Glu Phe Val Met Arg His 455 460 465 470 aaa gga gcc aag cac ctt
cgg gtt gca gcc cac gac ctc acc tgg ttc 1495 Lys Gly Ala Lys His
Leu Arg Val Ala Ala His Asp Leu Thr Trp Phe 475 480 485 cag tac cac
tct ttg gat gtg act ggg ttc ctg ctg gcc tgt gtg gca 1543 Gln Tyr
His Ser Leu Asp Val Thr Gly Phe Leu Leu Ala Cys Val Ala 490 495 500
act gtg ata ttc atc atc aca aaa tgt ctg ttt tgt gtc tgg aag ttt
1591 Thr Val Ile Phe Ile Ile Thr Lys Cys Leu Phe Cys Val Trp Lys
Phe 505 510 515 gtt aga aca gga aag aag ggg aaa aga gat taattacgtc
tgaggctgga 1641 Val Arg Thr Gly Lys Lys Gly Lys Arg Asp 520 525
agctgggaaa cccaataaat gaactccttt agtttattac aacaagaaga cgttgtgata
1701 caagagattc ctttcttctt gtgacaaaac atctttcaaa acttaccttg
tcaagtcaaa 1761 atttgtttta gtacctgttt aaccattaga aatatttcat
gtcaaggagg aaaacattag 1821 ggaaaacaaa aatgatataa agccatacga
ggttatattg aaatgtattg agcttatatt 1881 gaaatttatt gttccaattc
acaggttaca tgaaaaaaaa tttactaagc ttaactacat 1941 gtcacacatt
gtacatggaa acaagaacat taagaagtcc actgacagta tcagtactgt 2001
tttgcaaata ctcagcatac tttggatcca tttcatgcag gattgtgttg ttttaactgt
2061 tgttgaggaa actaataaat aattaaattg t 2092 8 528 PRT H. sapiens 8
Met Ser Met Lys Trp Thr Ser Ala Leu Leu Leu Ile Gln Leu Ser Cys 1 5
10 15 Tyr Phe Ser Ser Gly Ser Cys Gly Lys Val Leu Val Trp Pro Thr
Glu 20 25 30 Phe Ser His Trp Met Asn Ile Lys Thr Ile Leu Asp Glu
Leu Val Gln 35 40 45 Arg Gly His Glu Val Thr Val Leu Ala Ser Ser
Ala Ser Ile Ser Phe 50 55 60 Asp Pro Asn Ser Pro Ser Thr Leu Lys
Phe Glu Val Tyr Pro Val Ser 65 70 75 80 Leu Thr Lys Thr Glu Phe Glu
Asp Ile Ile Lys Gln Leu Val Lys Arg 85 90 95 Trp Ala Glu Leu Pro
Lys Asp Thr Phe Trp Ser Tyr Phe Ser Gln Val 100 105 110 Gln Glu Ile
Met Trp Thr Phe Asn Asp Ile Leu Arg Lys Phe Cys Lys 115 120 125 Asp
Ile Val Ser Asn Lys Lys Leu Met Lys Lys Leu Gln Glu Ser Arg 130 135
140 Phe Asp Val Val Leu Ala Asp Ala Val Phe Pro Phe Gly Glu Leu Leu
145 150 155 160 Ala Glu Leu Leu Lys Ile Pro Phe Val Tyr Ser Leu Arg
Phe Ser Pro 165 170 175 Gly Tyr Ala Ile Glu Lys His Ser Gly Gly Leu
Leu Phe Pro Pro Ser 180 185 190 Tyr Val Pro Val Val Met Ser Glu Leu
Ser Asp Gln Met Thr Phe Ile 195 200 205 Glu Arg Val Lys Asn Met Ile
Tyr Val Leu Tyr Phe Glu Phe Trp Phe 210 215 220 Gln Ile Phe Asp Met
Lys Lys Trp Asp Gln Phe Tyr Ser Glu Val Leu 225 230 235 240 Gly Arg
Pro Thr Thr Leu Ser Glu Thr Met Ala Lys Ala Asp Ile Trp 245 250 255
Leu Ile Arg Asn Tyr Trp Asp Phe Gln Phe Pro His Pro Leu Leu Pro 260
265 270 Asn Val Glu Phe Val Gly Gly Leu His Cys Lys Pro Ala Lys Pro
Leu 275 280 285 Pro Lys Glu Met Glu Glu Phe Val Gln Ser Ser Gly Glu
Asn Gly Val 290 295 300 Val Val Phe Ser Leu Gly Ser Met Val Ser Asn
Thr Ser Glu Glu Arg 305 310 315 320 Ala Asn Val Ile Ala Ser Ala Leu
Ala Lys Ile Pro Gln Lys Val Leu 325 330 335 Trp Arg Phe Asp Gly Asn
Lys Pro Asp Thr Leu Gly Leu Asn Thr Arg 340 345 350 Leu Tyr Lys Trp
Ile Pro Gln Asn Asp Leu Leu Gly His Pro Lys Thr 355 360 365 Arg Ala
Phe Ile Thr His Gly Gly Ala Asn Gly Ile Tyr Glu Ala Ile 370 375 380
Tyr His Gly Ile Pro Met Val Gly Val Pro Leu Phe Ala Asp Gln Pro 385
390 395
400 Asp Asn Ile Ala His Met Lys Ala Lys Gly Ala Ala Val Ser Leu Asp
405 410 415 Phe His Thr Met Ser Ser Thr Asp Leu Leu Asn Ala Leu Lys
Thr Val 420 425 430 Ile Asn Asp Pro Leu Tyr Lys Glu Asn Ala Met Lys
Leu Ser Arg Ile 435 440 445 His His Asp Gln Pro Val Lys Pro Leu Asp
Arg Ala Val Phe Trp Ile 450 455 460 Glu Phe Val Met Arg His Lys Gly
Ala Lys His Leu Arg Val Ala Ala 465 470 475 480 His Asp Leu Thr Trp
Phe Gln Tyr His Ser Leu Asp Val Thr Gly Phe 485 490 495 Leu Leu Ala
Cys Val Ala Thr Val Ile Phe Ile Ile Thr Lys Cys Leu 500 505 510 Phe
Cys Val Trp Lys Phe Val Arg Thr Gly Lys Lys Gly Lys Arg Asp 515 520
525 9 24 DNA H. sapiens 9 taccttttag ttgtctcttt gtca 24 10 21 DNA
H. sapiens 10 ttcctggagt cttctgtatg a 21 11 20 DNA H. sapiens 11
catcccttgt tcttctcatt 20 12 20 DNA H. sapiens 12 cgggactgga
aaataaatat 20 13 17 DNA H. sapiens 13 ggggtttcac cgtgtta 17 14 18
DNA H. sapiens 14 aaagccaagc agcactaa 18 15 20 DNA H. sapiens 15
ccacatgctc agactgttaa 20 16 19 DNA H. sapiens 16 caaaaatacc
ccactaccc 19 17 21 DNA H. sapiens 17 cccttgttct tctcattgtt a 21 18
22 DNA H. sapiens 18 ttcagtaagc ttgtttcatg at 22 19 17 DNA H.
sapiens 19 cctggccaaa ttgactt 17 20 18 DNA H. sapiens 20 caggaaccca
gtcacatc 18 21 21 DNA H. sapiens 21 ggggaaaaga gattaattac g 21 22
18 DNA H. sapiens 22 agccaagcag cactaatc 18 23 20 DNA H. sapiens 23
tccaattcac aggttacatg 20 24 18 DNA H. sapiens 24 agccaagcag
cactaatc 18 25 27 DNA H. sapiens 25 tggatgaata taaagacaat cctggat
27 26 27 DNA H. sapiens 26 tggatgaata taaacacaat cctggat 27 27 27
DNA H. sapiens 27 aagtgttaat agttatcatg aaacaag 27 28 27 DNA H.
sapiens 28 aagtgttaat agctatcatg aaacaag 27 29 27 DNA H. sapiens 29
tgaagcccct tgatcgagca gtcttct 27 30 27 DNA H. sapiens 30 tgaagcccct
tgaacgagca gtcttct 27 31 27 DNA H. sapiens 31 tgaagcccct tgatcgagca
gtcttct 27 32 27 DNA H. sapiens 32 tgaagcccct tgatagagca gtcttct 27
33 27 DNA H. sapiens 33 gatataaagc catacgaggt tatattg 27 34 27 DNA
H. sapiens 34 gatataaagc catatgaggt tatattg 27 35 26 DNA H. sapiens
35 caggttacat gaaaaaaaat ttacta 26 36 26 DNA H. sapiens 36
caggttacat gaaaaacaat ttacta 26 37 27 DNA H. sapiens 37 ttgttgagga
agctaataaa taattaa 27 38 27 DNA H. sapiens 38 ttgttgagga aactaataaa
taattaa 27 39 1854 DNA H. sapiens CDS (15)...(1584) 39 tgcattgcac
cagg atg tct gtg aaa tgg act tca gta att ttg cta ata 50 Met Ser Val
Lys Trp Thr Ser Val Ile Leu Leu Ile 1 5 10 caa ctg agc ttt tgc ttt
agc tct ggg aat tgt gga aag gtg ctg gtg 98 Gln Leu Ser Phe Cys Phe
Ser Ser Gly Asn Cys Gly Lys Val Leu Val 15 20 25 tgg gca gca gaa
tac agc cat tgg atg aat ata aag aca atc ctg gat 146 Trp Ala Ala Glu
Tyr Ser His Trp Met Asn Ile Lys Thr Ile Leu Asp 30 35 40 gag ctt
att cag aga ggt cat gag gtg act gta ctg gca tct tca gct 194 Glu Leu
Ile Gln Arg Gly His Glu Val Thr Val Leu Ala Ser Ser Ala 45 50 55 60
tcc att ctt ttt gat ccc aac aac tca tcc gct ctt aaa att gaa att 242
Ser Ile Leu Phe Asp Pro Asn Asn Ser Ser Ala Leu Lys Ile Glu Ile 65
70 75 tat ccc aca tct tta act aaa act gag ttg gag aat ttc atc atg
caa 290 Tyr Pro Thr Ser Leu Thr Lys Thr Glu Leu Glu Asn Phe Ile Met
Gln 80 85 90 cag att aag aga tgg tca gac ctt cca aaa gat aca ttt
tgg tta tat 338 Gln Ile Lys Arg Trp Ser Asp Leu Pro Lys Asp Thr Phe
Trp Leu Tyr 95 100 105 ttt tca caa gta cag gaa atc atg tca ata ttt
ggt gac ata act aga 386 Phe Ser Gln Val Gln Glu Ile Met Ser Ile Phe
Gly Asp Ile Thr Arg 110 115 120 aag ttc tgt aaa gat gta gtt tca aat
aag aaa ttt atg aaa aaa gta 434 Lys Phe Cys Lys Asp Val Val Ser Asn
Lys Lys Phe Met Lys Lys Val 125 130 135 140 caa gag tca aga ttt gac
gtc att ttt gca gat gct att ttt ccc tgt 482 Gln Glu Ser Arg Phe Asp
Val Ile Phe Ala Asp Ala Ile Phe Pro Cys 145 150 155 agt gag ctg ctg
gct gag cta ttt aac ata ccc ttt gtg tac agt ctc 530 Ser Glu Leu Leu
Ala Glu Leu Phe Asn Ile Pro Phe Val Tyr Ser Leu 160 165 170 agc ttc
tct cct ggc tac act ttt gaa aag cat agt gga gga ttt att 578 Ser Phe
Ser Pro Gly Tyr Thr Phe Glu Lys His Ser Gly Gly Phe Ile 175 180 185
ttc cct cct tcc tac gta cct gtt gtt atg tca gaa tta act gat caa 626
Phe Pro Pro Ser Tyr Val Pro Val Val Met Ser Glu Leu Thr Asp Gln 190
195 200 atg act ttc atg gag agg gta aaa aat atg atc tat gtg ctt tac
ttt 674 Met Thr Phe Met Glu Arg Val Lys Asn Met Ile Tyr Val Leu Tyr
Phe 205 210 215 220 gac ttt tgg ttc gaa ata ttt gac atg aag aag tgg
gat cag ttt tat 722 Asp Phe Trp Phe Glu Ile Phe Asp Met Lys Lys Trp
Asp Gln Phe Tyr 225 230 235 agt gaa gtt cta gga aga ccc act aca tta
tct gag aca atg ggg aaa 770 Ser Glu Val Leu Gly Arg Pro Thr Thr Leu
Ser Glu Thr Met Gly Lys 240 245 250 gct gac gta tgg ctt att cga aac
tcc tgg aat ttt cag ttt cca tat 818 Ala Asp Val Trp Leu Ile Arg Asn
Ser Trp Asn Phe Gln Phe Pro Tyr 255 260 265 cca ctc tta cca aat gtt
gat ttt gtt gga gga ctc cac tgc aaa cct 866 Pro Leu Leu Pro Asn Val
Asp Phe Val Gly Gly Leu His Cys Lys Pro 270 275 280 gcc aaa ccc ctg
cct aag gaa atg gaa gac ttt gta cag agc tct gga 914 Ala Lys Pro Leu
Pro Lys Glu Met Glu Asp Phe Val Gln Ser Ser Gly 285 290 295 300 gaa
aat ggt gtt gtg gtg ttt tct ctg ggg tca atg gtc agt aac atg 962 Glu
Asn Gly Val Val Val Phe Ser Leu Gly Ser Met Val Ser Asn Met 305 310
315 aca gaa gaa agg gcc aac gta att gca tca gcc ctg gcc cag atc cca
1010 Thr Glu Glu Arg Ala Asn Val Ile Ala Ser Ala Leu Ala Gln Ile
Pro 320 325 330 caa aag gtt ctg tgg aga ttt gat ggg aat aaa cca gat
acc tta ggt 1058 Gln Lys Val Leu Trp Arg Phe Asp Gly Asn Lys Pro
Asp Thr Leu Gly 335 340 345 ctc aat act cgg ctc tac aag tgg ata ccc
cag aat gac ctt cta ggt 1106 Leu Asn Thr Arg Leu Tyr Lys Trp Ile
Pro Gln Asn Asp Leu Leu Gly 350 355 360 cat cca aag acc aga gct ttt
ata act cat ggt gga gcc aat ggc atc 1154 His Pro Lys Thr Arg Ala
Phe Ile Thr His Gly Gly Ala Asn Gly Ile 365 370 375 380 tac gag gca
atc tac cat ggg atc cct atg gtg ggg att cca ttg ttt 1202 Tyr Glu
Ala Ile Tyr His Gly Ile Pro Met Val Gly Ile Pro Leu Phe 385 390 395
gcc gat caa cct gat aac att gct cac atg aag gcc agg gga gca gct
1250 Ala Asp Gln Pro Asp Asn Ile Ala His Met Lys Ala Arg Gly Ala
Ala 400 405 410 gtt aga gtg gac ttc aac aca atg tcg agt aca gac ttg
ctg aat gca 1298 Val Arg Val Asp Phe Asn Thr Met Ser Ser Thr Asp
Leu Leu Asn Ala 415 420 425 ttg aag aga gta att aat gat cct tca tat
aaa gag aat gtt atg aaa 1346 Leu Lys Arg Val Ile Asn Asp Pro Ser
Tyr Lys Glu Asn Val Met Lys 430 435 440 tta tca aga att caa cat gat
caa cca gtg aag ccc ctg gat cga gca 1394 Leu Ser Arg Ile Gln His
Asp Gln Pro Val Lys Pro Leu Asp Arg Ala 445 450 455 460 gtc ttc tgg
att gaa ttt gtc atg cgc cac aaa gga gct aaa cac ctt 1442 Val Phe
Trp Ile Glu Phe Val Met Arg His Lys Gly Ala Lys His Leu 465 470 475
cgg gtt gca gcc cac gac ctc acc tgg ttc cag tac cac tct ttg gat
1490 Arg Val Ala Ala His Asp Leu Thr Trp Phe Gln Tyr His Ser Leu
Asp 480 485 490 gtg att ggg ttc ctg ctg gtc tgt gtg gca act gtg ata
ttt atc gtc 1538 Val Ile Gly Phe Leu Leu Val Cys Val Ala Thr Val
Ile Phe Ile Val 495 500 505 aca aaa tgt tgt ctg ttt tgt ttc tgg aag
ttt gct aga aaa gca a 1584 Thr Lys Cys Cys Leu Phe Cys Phe Trp Lys
Phe Ala Arg Lys Ala 510 515 520 agaagggaaa aaatgattag ttatatctga
gatttgaagc tggaaaacct gataggtgag 1644 actacttcag tttattccag
caagaaagat tgtgatgcaa gatttctttc ttcctgagac 1704 aaaaaaaaaa
aaagaaaaaa aaatcttttc aaaatttact ttgtcaaata aaaatttgtt 1764
tttcagagat ttaccaccca gttcatggtt agaaatattt tgtggcaatg aagaaaacac
1824 tacggaaaat aaaaaataag ataaagcctt 1854 40 524 PRT H. sapiens 40
Met Ser Val Lys Trp Thr Ser Val Ile Leu Leu Ile Gln Leu Ser Phe 1 5
10 15 Cys Phe Ser Ser Gly Asn Cys Gly Lys Val Leu Val Trp Ala Ala
Glu 20 25 30 Tyr Ser His Trp Met Asn Ile Lys Thr Ile Leu Asp Glu
Leu Ile Gln 35 40 45 Arg Gly His Glu Val Thr Val Leu Ala Ser Ser
Ala Ser Ile Leu Phe 50 55 60 Asp Pro Asn Asn Ser Ser Ala Leu Lys
Ile Glu Ile Tyr Pro Thr Ser 65 70 75 80 Leu Thr Lys Thr Glu Leu Glu
Asn Phe Ile Met Gln Gln Ile Lys Arg 85 90 95 Trp Ser Asp Leu Pro
Lys Asp Thr Phe Trp Leu Tyr Phe Ser Gln Val 100 105 110 Gln Glu Ile
Met Ser Ile Phe Gly Asp Ile Thr Arg Lys Phe Cys Lys 115 120 125 Asp
Val Val Ser Asn Lys Lys Phe Met Lys Lys Val Gln Glu Ser Arg 130 135
140 Phe Asp Val Ile Phe Ala Asp Ala Ile Phe Pro Cys Ser Glu Leu Leu
145 150 155 160 Ala Glu Leu Phe Asn Ile Pro Phe Val Tyr Ser Leu Ser
Phe Ser Pro 165 170 175 Gly Tyr Thr Phe Glu Lys His Ser Gly Gly Phe
Ile Phe Pro Pro Ser 180 185 190 Tyr Val Pro Val Val Met Ser Glu Leu
Thr Asp Gln Met Thr Phe Met 195 200 205 Glu Arg Val Lys Asn Met Ile
Tyr Val Leu Tyr Phe Asp Phe Trp Phe 210 215 220 Glu Ile Phe Asp Met
Lys Lys Trp Asp Gln Phe Tyr Ser Glu Val Leu 225 230 235 240 Gly Arg
Pro Thr Thr Leu Ser Glu Thr Met Gly Lys Ala Asp Val Trp 245 250 255
Leu Ile Arg Asn Ser Trp Asn Phe Gln Phe Pro Tyr Pro Leu Leu Pro 260
265 270 Asn Val Asp Phe Val Gly Gly Leu His Cys Lys Pro Ala Lys Pro
Leu 275 280 285 Pro Lys Glu Met Glu Asp Phe Val Gln Ser Ser Gly Glu
Asn Gly Val 290 295 300 Val Val Phe Ser Leu Gly Ser Met Val Ser Asn
Met Thr Glu Glu Arg 305 310 315 320 Ala Asn Val Ile Ala Ser Ala Leu
Ala Gln Ile Pro Gln Lys Val Leu 325 330 335 Trp Arg Phe Asp Gly Asn
Lys Pro Asp Thr Leu Gly Leu Asn Thr Arg 340 345 350 Leu Tyr Lys Trp
Ile Pro Gln Asn Asp Leu Leu Gly His Pro Lys Thr 355 360 365 Arg Ala
Phe Ile Thr His Gly Gly Ala Asn Gly Ile Tyr Glu Ala Ile 370 375 380
Tyr His Gly Ile Pro Met Val Gly Ile Pro Leu Phe Ala Asp Gln Pro 385
390 395 400 Asp Asn Ile Ala His Met Lys Ala Arg Gly Ala Ala Val Arg
Val Asp 405 410 415 Phe Asn Thr Met Ser Ser Thr Asp Leu Leu Asn Ala
Leu Lys Arg Val 420 425 430 Ile Asn Asp Pro Ser Tyr Lys Glu Asn Val
Met Lys Leu Ser Arg Ile 435 440 445 Gln His Asp Gln Pro Val Lys Pro
Leu Asp Arg Ala Val Phe Trp Ile 450 455 460 Glu Phe Val Met Arg His
Lys Gly Ala Lys His Leu Arg Val Ala Ala 465 470 475 480 His Asp Leu
Thr Trp Phe Gln Tyr His Ser Leu Asp Val Ile Gly Phe 485 490 495 Leu
Leu Val Cys Val Ala Thr Val Ile Phe Ile Val Thr Lys Cys Cys 500 505
510 Leu Phe Cys Phe Trp Lys Phe Ala Arg Lys Ala Lys 515 520 41 1686
DNA H. sapiens exon (392)...(1126) 41 tccccagttt cacaaaaata
tgtggaccat gtttagtcat ttaatcttta gttttgtgtc 60 aaatggactg
cagaaacaag atctgtcact gctactgttc tggacactct tctaaaatat 120
attgcataag acagatggca tgtccataca agatccttga tattagctga aggatagcac
180 tcataaacat aaaagggaaa ttaatcacat ctgtgtgaac agatcattta
ccttcatttg 240 tctctttgcc atccacatgc tcagactgtt gatttaatga
tattgtatgt actttgactt 300 ataagggtta cattttaact tcttggctaa
tttatctttg gacataacca tgagaaatga 360 cagaaaggaa cagcaactgg
aaaacaagca ttgcattgca ccaggatgtc tgtgaaatgg 420 acttcagtaa
ttttgctaat acaactgagc ttttgcttta gctctgggaa ttgtggaaag 480
gtgctggtgt gggcagcaga atacagccat tggatgaata taaagacaat cctggatgag
540 cttattcaga gaggtcatga ggtgactgta ctggcatctt cagcttccat
tctttttgat 600 cccaacaact catccgctct taaaattgaa atttatccca
catctttaac taaaactgag 660 ttggagaatt tcatcatgca acagattaag
agatggtcag accttccaaa agatacattt 720 tggttatatt tttcacaagt
acaggaaatc atgtcaatat ttggtgacat aactagaaag 780 ttctgtaaag
atgtagtttc aaataagaaa tttatgaaaa aagtacaaga gtcaagattt 840
gacgtcattt ttgcagatgc tatttttccc tgtagtgagc tgctggctga gctatttaac
900 ataccctttg tgtacagtct cagcttctct cctggctaca cttttgaaaa
gcatagtgga 960 ggatttattt tccctccttc ctacgtacct gttgttatgt
cagaattaac tgatcaaatg 1020 actttcatgg agagggtaaa aaatatgatc
tatgtgcttt actttgactt ttggttcgaa 1080 atatttgaca tgaagaagtg
ggatcagttt tatagtgaag ttctaggtaa gtattttttt 1140 caatcagtaa
catgaagctc taacttattt gtgtctttga agcagagctt atataaagcc 1200
ataaagtcag ggtagtgggg ttttggtaag tgaatttata aaacaaaaat acaagatgat
1260 ctattaatct cacaaatatt atagaaaagc ttaaattaca gggtcagtta
aaaccctgtg 1320 gccatcactc acacagaaca ccccaggaaa tcataaacct
atacattagt gcatctaaga 1380 ctttaagcaa ttacacatct gttttactat
acattgtttt acatcttaaa aacagtaaaa 1440 tccatcaaat aacttcttac
tgaatgcata gatttagaat gagtagttac acatttttct 1500 acaactatct
atataactgc agaaattgtt ttttcttgta aacttgtttt cttatttaga 1560
aatcaaaaga tgttcccata ttaccagaag gtttccttca cagtaaagag agataatgtc
1620 tatacctcag atgcaaaaat caataagggc aatttgaagt ttctaatgtt
tctatactct 1680 tgcagg 1686 42 1340 DNA H. sapiens exon
(668)...(816) 42 atagtttttg gaactaggcc cctttattag aacatatgag
acaattaagg tggagtacaa 60 tttttatttc ataatttctc aaaaatttct
agctataatg tacaaatata tttacttaaa 120 aatattatta agatcttagc
ttgaatctaa aagagtagtt ggtacaagga tttcagccat 180 actctcaaca
tagtccacag ttcacttgaa ccaaagataa aagaattagc ttaatgagtt 240
gtgtaaacta gactatttct tagaaaatta tttttatggg tagagtagaa ttaattgatt
300 atggagctca aagagttgtt taaatgtccg tatgctacta ttgaagcttt
aagagaaaag 360 aaattttatg tttaactttc tatggctcat tttaataatt
gtttatgatt atgagcatac 420 tgatgcgaca ttagagatgt agcttaacct
cacaattctc ctactacttt gtctttctta 480 taaatacaca tgggcaaaat
atgtaataca taaaattaaa ttatatctat atatgaatat 540 gtgtatatat
ttttcaaagc acagatattt gcctacattt ttgcctacat tattctaacc 600
cctttcagaa atttacctaa agtaattatc ttgtgtcatc cacctttttt ttttctattc
660 ctgtcaggaa gacccactac attatctgag acaatgggga aagctgacgt
atggcttatt 720 cgaaactcct ggaattttca gtttccatat ccactcttac
caaatgttga ttttgttgga 780 ggactccact gcaaacctgc caaacccctg
cctaaggtaa acatactttt gttggtttta 840 ttttgttggc tttgaatttt
cagtagaaat gattctatag tcttctttca gagtgtttga 900 cttacactga
aagaaagatg ggaaatgggt ggggtaaagc agataccaat tagaaactca 960
tgtgcacgtt aataccatca cacgtatatg agttttatga gtattacaaa tagagaggaa
1020 tactaaggag actttgaaaa tagggttggt taaattaaag tcttcattat
gcaataccta 1080 agaaggtatt ggtcatccaa tcaaataata tttacaaagg
gattagcaca aaacacaggt 1140 aagtgcagaa ttttcagaga aaaaaataga
cacagtttct gtccccacat accttacatt 1200 ctacttcaaa agatagaata
tgtgcaagta ataaaaatta tataaaaact attatctgaa 1260 ggaaaaacgc
aataccaaga aagcatcagt ggagataata gaaagtatcc tgcagtcact 1320
gattagtaag atgggtaccg 1340 43 1822 DNA H. sapiens exon
(732)...(863) 43 tatatacaat gtctgtatga taaatgagac tcctggcact
aattcataga aattccaaat 60 tacattacca gactccagaa tgtcagcggt
tcttaaccac cagcttttat ttattttatt 120 ttttttagtt tttgaaaaac
taccagaaaa ctctgaacaa actttaagtg aagtataaag 180 cattgtagag
aaacataaat gtagatataa aattatccca actgtgagta gcttatcctc 240
agagctcata gttagggaag taaaccacta actgtttcca actaagagaa ttctacagaa
300 aacctgcctg aaataaacac aagggattta gtagaacaac aatataggat
taaagctgag 360 tggtcccact ttccaagaac ctatattagt aactttagta
atgaaagtga agagtcgtgt 420 attaatattt ttaacattat ctccctgaca
acaatgtaat agctccattt cttttctccc 480 ttacacacat gcacacaaat
acatacacat acacacatat ttacacaaat atccttaaca 540 gcatccacct
atctcatatt atacatctac ttgcaaaaaa actgagtgat tgggtcagtt 600
aaaaaatatt atttactcca ataattcctc aaaatactgg attttctctc tttagtaatt
660 tgcaccaatt cttttggtag tgcccgctgt gctaatactc ttttgtgatg
aagcaaattc 720 tttcttcaca ggaaatggaa gactttgtac agagctctgg
agaaaatggt gttgtggtgt 780 tttctctggg gtcaatggtc agtaacatga
cagaagaaag ggccaacgta attgcatcag 840 ccctggccca gatcccacaa
aaggtaagat gaagtgcctt actggtgtgg aaaactactg 900 aaagaggctg
ttaaagtttg aagtaatcca attatagaaa cttctgataa atgtgaagtt 960
gaccaaaagt tgaaaaatta gaacaaggat aatcttggag aaactatgag aagtttgaaa
1020 attgtggttg catttttttt taaatggtgt taagtatgaa cattccccta
tgtaaatatg 1080 ctgacaataa attgaatgga gaaaggtatt taaaaagtgt
ttggagactt ctcacctcct 1140 gtccataaaa ttttgaattg tgtatgtgat
ctacatagga aaggatatta aagagtagat 1200 tgaactcttc catagctgaa
tatagcctta aatatgcttg tatagcatcc accgacagaa 1260 gtaatagttg
tgcctcagac ttaggggttg catgtggccc tggaggagtt actacccttg 1320
gtatgcatga gtagttccta ttagcatcag tgggaactca gtactccata tgtattcaca
1380 aaaggcaact tgagacccac agttattttt aatttctgat attaacactc
atacatactg 1440 ctgaatttaa ctcaatatat ttcagttaag tgaaaatggt
gcttaatgta gtctttagaa 1500 tgactttcag gtgttttcac aaaaaacgta
tatccagaac tgtgtccttt tagaaataca 1560 agtaaaattt ttgataatta
gcttcaaaac agttttccta atctcagcag tatccaatga 1620 gtgaagaaca
cttgactgac tcttgggtca cctctattac ttattgtact ctggaagctc 1680
ttggtgaatg tttacgatta tgggatgtag tatttctgtt tgcactttaa gtcaaatgct
1740 tgtataaaat acgtgacaac aaatggagaa tattggctct gttagtagtt
atgcggtata 1800 ttctctgttt aaggatcttt gg 1822 44 1591 DNA H.
sapiens exon (138)...(225) exon (1067)...(1286) 44 attctattta
cattagcctt tgagtagttc ttatttacta acatcccttg atctcattcc 60
tactctttat acagttctca cattctataa cttttgaatt ccactcatgg aataaaatat
120 tttctttatt gtaacaggtt ctgtggagat ttgatgggaa taaaccagat
accttaggtc 180 tcaatactcg gctctacaag tggatacccc agaatgacct
tctaggtaag actctggtga 240 acaaatactg aatatattag taacagcaca
ttagagtgtt aatagttcat catgaaacaa 300 gcttattgaa tatttgttaa
ggaaaaacaa aatgtaactt ctttatattg attttccagt 360 cttaagggag
aaagaataca ttataatttt tggcatttta tgatatacac ccacattctt 420
tatagtctga atcgggggaa tctttatttc aggtgttatt atatctcaca aaatttttca
480 ataacttcct gggctgtctc tctgtctcct atttctacaa ctttacacct
gtttttttcc 540 tctcccgcag ggttatttga aatgccacta aaaataatag
ctcttctatc accagtgact 600 ctgtattttc tgaagaatta aactgctaat
cttaatcata cagtgatgat acatttcacg 660 atgaagtgtg acctgtcctt
cctcaatcct agcaccacca ccaaaccact gcctgctgcc 720 ttgcccaccc
catatatcac actctgtgac tgtcacttaa aataagagtt cacttcatgc 780
ctatctcttt gctgtcttct tttttgcaca tttttgaaat ctagaatgca atttttcatt
840 agcccaactg gaaatcttgt attgttttgc agtctgaagt cacacacacc
gtatagcctt 900 cagttacata cccagtacaa gtacgtgttt tttcctccga
agtctgaaac acaattttaa 960 tttagttcag tgttttagct ggaaaacact
gtcactttca gagcctttca ttgtgcatct 1020 cattttattc ctatgagtaa
ttttgctaaa attcatccaa tcctaggtca tccaaagacc 1080 agagctttta
taactcatgg tggagccaat ggcatctacg aggcaatcta ccatgggatc 1140
cctatggtgg ggattccatt gtttgccgat caacctgata acattgctca catgaaggcc
1200 aggggagcag ctgttagagt ggacttcaac acaatgtcga gtacagactt
gctgaatgca 1260 ttgaagagag taattaatga tccttcgtga gtagaacaat
atttttcact aggtggtatt 1320 tacagatagc ttctcttgtc aatagtgagt
gtgagtttca tcctttttat aagagactaa 1380 ttttgaaaga atttaatgat
ttaaccaatc tgaaatctgc ttttattttt ataagttatt 1440 taaaaattga
atttgaaaca catacatcta aagaatagcc agttagtgaa acaattttct 1500
acacaaaaat aattttaaaa ggatatagat aatacaaaaa atacatttct taaaaatttg
1560 acataattaa tccatagaag aaaggaagaa t 1591 45 596 DNA H. sapiens
exon (19)...(549) 45 ctttattttt atctttcaga tataaagaga atgttatgaa
attatcaaga attcaacatg 60 atcaaccagt gaagcccctg gatcgagcag
tcttctggat tgaatttgtc atgcgccaca 120 aaggagctaa acaccttcgg
gttgcagccc acgacctcac ctggttccag taccactctt 180 tggatgtgat
tgggttcctg ctggtctgtg tggcaactgt gatatttatc gtcacaaaat 240
gttgtctgtt ttgtttctgg aagtttgcta gaaaagcaaa gaagggaaaa aatgattagt
300 tatatctgag atttgaagct ggaaaacctg ataggtgaga ctacttcagt
ttattccagc 360 aagaaagatt gtgatgcaag atttctttct tcctgagaca
aaaaaaaaaa aagaaaaaaa 420 aatcttttca aaatttactt tgtcaaataa
aaatttgttt ttcagagatt taccacccag 480 ttcatggtta gaaatatttt
gtggcaatga agaaaacact acggaaaata aaaaataaga 540 taaagcctta
tgagctcgta ttgaaatttg ttgaacttat atcgcggatc ctactg 596 46 20 DNA H.
sapiens 46 cttggctaat ttatctttgg 20 47 19 DNA H. sapiens 47
cccactaccc tgactttat 19 48 20 DNA H. sapiens 48 ggacataacc
atgagaaatg 20 49 19 DNA H. sapiens 49 agctctgctt caaagacac 19 50 21
DNA H. sapiens 50 tgtccgtatg ctactattga a 21 51 21 DNA H. sapiens
51 tgtgctaatc cctttgtaaa t 21 52 22 DNA H. sapiens 52 tttttttttc
tattcctgtc ag 22 53 17 DNA H. sapiens 53 ctttacccca cccattt 17 54
20 DNA H. sapiens 54 cccttgatct cattcctact 20 55 24 DNA H. sapiens
55 aactggctat tctttagatg tatg 24 56 25 DNA H. sapiens 56 cattcctact
ctttatacag ttctc 25 57 17 DNA H. sapiens 57 cccccgattc agactat 17
58 20 DNA H. sapiens 58 cccttgatct cattcctact 20 59 24 DNA H.
sapiens 59 aactggctat tctttagatg tatg 24 60 18 DNA H. sapiens 60
tcctccgaag tctgaaac 18 61 23 DNA H. sapiens 61 tataaaaagg
atgaaactca cac 23 62 18 DNA H. sapiens 62 caagccccca agttatgt 18 63
20 DNA H. sapiens 63 cagtaggatc cgcgatataa 20 64 20 DNA H. sapiens
64 tctgaggggt tttgtctgta 20 65 20 DNA H. sapiens 65 ccgcgatata
agttcaacaa 20 66 20 DNA H. sapiens 66 ggacataacc atgagaaatg 20 67
19 DNA H. sapiens 67 ttaagagcgg atgagttgt 19 68 20 DNA H. sapiens
68 tcatcatgca acagattaag 20 69 20 DNA H. sapiens 69 cactacaggg
aaaaatagca 20 70 20 DNA H. sapiens 70 accctttgtg tacagtctca 20 71
19 DNA H. sapiens 71 agctctgctt caaagacac 19 72 21 DNA H. sapiens
72 ttgcctacat tattctaacc c 21 73 17 DNA H. sapiens 73 ctttacccca
cccattt 17 74 25 DNA H. sapiens 74 cattcctact ctttatacag ttctc 25
75 17 DNA H. sapiens 75 cccccgattc agactat 17 76 25 DNA H. sapiens
76 cattcctact ctttatacag ttctc 25 77 17 DNA H. sapiens 77
cccccgattc agactat 17 78 18 DNA H. sapiens 78 tcctccgaag tctgaaac
18 79 23 DNA H. sapiens 79 tataaaaagg atgaaactca cac 23 80 20 DNA
H. sapiens 80 tctgaggggt tttgtctgta 20 81 22 DNA H. sapiens 81
ttttttgtct caggaagaaa ga 22 82 24 DNA H. sapiens 82 aaaaaaagaa
aaaaaaatct tttc 24 83 20 DNA H. sapiens 83 ccgcgatata agttcaacaa 20
84 22 DNA H. sapiens 84 tgcattgcac caggatgtct gt 22 85 21 DNA H.
sapiens 85 gcattgcacc aagatgtctg t 21 86 23 DNA H. sapiens 86
tcctggatga gcttattcag aga 23 87 23 DNA H. sapiens 87 tcctggatga
gcctattcag aga 23 88 21 DNA H. sapiens 88 cattttggtt atatttttca c
21 89 21 DNA H. sapiens 89 cattttggtt ttatttttca c 21 90 21 DNA H.
sapiens 90 cataactaga aagttctgta a 21 91 21 DNA H. sapiens 91
cataactagg aagttctgta a 21 92 20 DNA H. sapiens 92 cctggctaca
cttttgaaaa 20 93 20 DNA H. sapiens 93 cctggctaca tttttgaaaa 20 94
21 DNA H. sapiens 94 gaagacccac tacattatct g 21 95 21 DNA H.
sapiens 95 gaagacccac tacgttatct g 21 96 26 DNA H. sapiens 96
aattttcagt ttccatatcc actctt 26 97 26 DNA H. sapiens 97 aattttcagt
ttcctcatcc actctt 26 98 22 DNA H. sapiens 98 taggtctcaa tactcggctc
ta 22 99 22 DNA H. sapiens 99 taggtctcaa tactcggctg ta 22 100 19
DNA H. sapiens 100 tacaagtgga taccccaga 19 101 19 DNA H. sapiens
101 tataagtgga taccccaga 19 102 26 DNA H. sapiens 102 gggagaaaga
atacattata attttt 26 103 25 DNA H. sapiens 103 gggagaaaga
atacttataa ttttt 25 104 21 DNA H. sapiens 104 ttccattgtt tgccgatcaa
c 21 105 21 DNA H. sapiens 105 ttccattgtt tgctgatcaa c 21 106 21
DNA H. sapiens 106 gaatgcattg aagagagtaa t 21 107 21 DNA H. sapiens
107 gaatgcattg cagagagtaa t 21 108 22 DNA H. sapiens 108 ctggtctgtg
tggcaactgt ga 22 109 22 DNA H. sapiens 109 ctggtctgtg tggcgactgt ga
22 110 19 DNA H. sapiens 110 taagataaag ccttatgag 19 111 19 DNA H.
sapiens 111 taagataaag acttatgag 19 112 1976 DNA H. sapiens CDS
(11)...(1598) 112 taagaccagg atg tct ctg aaa tgg acg tca gtc ttt
ctg ctg ata cag 49 Met Ser Leu Lys Trp Thr Ser Val Phe Leu Leu Ile
Gln 1 5 10 ctc agt tgt tac ttt agc tct gga agc tgt gga aag gtg cta
gtg tgg 97 Leu Ser Cys Tyr Phe Ser Ser Gly Ser Cys Gly Lys Val Leu
Val Trp 15 20 25 ccc aca gaa tac agc cat tgg ata aat atg aag aca
atc ctg gaa gag 145 Pro Thr Glu Tyr Ser His Trp Ile Asn Met Lys Thr
Ile Leu Glu Glu 30 35 40 45 ctt gtt cag agg ggt cat gag gtg act gtg
ttg aca tct tcg gct tct 193 Leu Val Gln Arg Gly His Glu Val Thr Val
Leu Thr Ser Ser Ala Ser 50 55 60 act ctt gtc aat gcc agt aaa tca
tct gct att aaa tta gaa gtt tat 241 Thr Leu Val Asn Ala Ser Lys Ser
Ser Ala Ile Lys Leu Glu Val Tyr 65 70 75 cct aca tct tta act aaa
aat gat ttg gaa gat tct ctt ctg aaa att 289 Pro Thr Ser Leu Thr Lys
Asn Asp Leu Glu Asp Ser Leu Leu Lys Ile 80 85 90 ctc gat aga tgg
ata tat ggt gtt tca aaa aat aca ttt tgg tca tat 337 Leu Asp Arg Trp
Ile Tyr Gly Val Ser Lys Asn Thr Phe Trp Ser Tyr 95 100 105 ttt tca
caa tta caa gaa ttg tgt tgg gaa tat tat gac tac agt aac 385 Phe Ser
Gln Leu Gln Glu Leu Cys Trp Glu Tyr Tyr Asp Tyr Ser Asn 110 115 120
125 aag ctc tgt aaa gat gca gtt ttg aat aag aaa ctt atg atg aaa cta
433 Lys Leu Cys Lys Asp Ala Val Leu Asn Lys Lys Leu Met Met Lys Leu
130 135 140 caa gag tca aag ttt gat gtc att ctg gca gat gcc ctt aat
ccc tgt 481 Gln Glu Ser Lys Phe Asp Val Ile Leu Ala Asp Ala Leu Asn
Pro Cys 145 150 155 ggt gag cta ctg gct gaa cta ttt aac ata ccc ttt
ctg tac agt ctt 529 Gly Glu Leu Leu Ala Glu Leu Phe Asn Ile Pro Phe
Leu Tyr Ser Leu 160 165 170 cga ttc tct gtt ggc tac aca ttt gag aag
aat ggt gga gga ttt ctg 577 Arg Phe Ser Val Gly Tyr Thr Phe Glu Lys
Asn Gly Gly Gly Phe Leu 175 180 185 ttc cct cct tcc tat gta cct gtt
gtt atg tca gaa tta agt gat caa 625 Phe Pro Pro Ser Tyr Val Pro Val
Val Met Ser Glu Leu Ser Asp Gln 190 195 200 205 atg att ttc atg gag
agg ata aaa aat atg ata cat atg ctt tat ttt 673 Met Ile Phe Met Glu
Arg Ile Lys Asn Met Ile His Met Leu Tyr Phe 210 215 220 gac ttt tgg
ttt caa att tat gat ctg aag aag tgg gac cag ttt tat 721 Asp Phe Trp
Phe Gln Ile Tyr Asp Leu Lys Lys Trp Asp Gln Phe Tyr 225 230 235 agt
gaa gtt cta gga aga ccc act aca tta ttt gag aca atg ggg aaa 769 Ser
Glu Val Leu Gly Arg Pro Thr Thr Leu Phe Glu Thr Met Gly Lys 240 245
250 gct gaa atg tgg ctc att cga acc tat tgg gat ttt gaa ttt cct cgc
817 Ala Glu Met Trp Leu Ile Arg Thr Tyr Trp Asp Phe Glu Phe Pro Arg
255 260 265 cca ttc tta cca aat gtt gat ttt gtt gga gga ctt cac tgt
aaa cca 865 Pro Phe Leu Pro Asn Val Asp Phe Val Gly Gly Leu His Cys
Lys Pro 270 275 280 285 gcc aaa ccc ctg cct aag gaa atg gaa gag ttt
gtg cag agc tct gga 913 Ala Lys Pro Leu Pro Lys Glu Met Glu Glu Phe
Val Gln Ser Ser Gly 290 295 300 gaa aat ggt att gtg gtg ttt tct ctg
ggg tcg atg atc agt aac atg 961 Glu Asn Gly Ile Val Val Phe Ser Leu
Gly Ser Met Ile Ser Asn Met 305 310 315 tca gaa gaa agt gcc aac atg
att gca tca gcc ctt gcc cag atc cca 1009 Ser Glu Glu Ser Ala Asn
Met Ile Ala Ser Ala Leu Ala Gln Ile Pro 320 325 330 caa aag gtt cta
tgg aga ttt gat ggc aag aag cca aat act tta ggt 1057 Gln Lys Val
Leu Trp Arg Phe Asp Gly Lys Lys Pro Asn Thr Leu Gly 335 340 345 tcc
aat act cga ctg tac aag tgg tta ccc cag aat gac ctt ctt ggt 1105
Ser Asn Thr Arg Leu Tyr Lys Trp Leu Pro Gln Asn Asp Leu Leu Gly 350
355 360 365 cat ccc aaa acc aaa gct ttt ata act cat ggt gga acc aat
ggc atc 1153 His Pro Lys Thr Lys Ala Phe Ile Thr His Gly Gly Thr
Asn Gly Ile 370 375 380 tat gag gcg atc tac cat ggg atc cct atg gtg
ggc att ccc ttg ttt 1201 Tyr Glu Ala Ile Tyr His Gly Ile Pro Met
Val Gly Ile Pro Leu Phe 385 390 395 gcg gat caa cat gat aac att gct
cac atg aaa gcc aag gga gca gcc 1249 Ala Asp Gln His Asp Asn Ile
Ala His Met Lys Ala Lys Gly Ala Ala 400 405 410 ctc agt gtg gac atc
agg acc atg tca agt aga gat ttg ctc aat gca 1297 Leu Ser Val Asp
Ile Arg Thr Met Ser Ser Arg Asp Leu Leu Asn Ala 415 420 425 ttg aag
tca gtc att aat gac cct gtc tat aaa gag aat gtc atg aaa 1345 Leu
Lys Ser Val Ile Asn Asp Pro Val Tyr Lys Glu Asn Val Met Lys 430 435
440 445 tta tca aga att cat cat gac caa cca atg aag ccc ctg gat cga
gca 1393 Leu Ser Arg Ile His His Asp Gln Pro Met Lys Pro Leu Asp
Arg Ala 450 455 460 gtc ttc tgg att gag ttt gtc atg cgc cac aaa gga
gcc aag cac ctt 1441 Val Phe Trp Ile Glu Phe Val Met Arg His Lys
Gly Ala Lys His Leu 465 470 475 cga gtc gca gct cac aac ctc acc tgg
atc cag tac cac tct ttg gat 1489 Arg Val Ala Ala His Asn Leu Thr
Trp Ile Gln Tyr His Ser Leu Asp 480 485 490 gtg ata gca ttc ctg ctg
gcc tgc gtg gca act gtg ata ttt atc atc 1537 Val Ile Ala Phe Leu
Leu Ala Cys Val Ala Thr Val Ile Phe Ile Ile 495 500 505 aca aaa ttt
tgc ctg ttt tgt ttc cga aag ctt gcc aaa aca gga aag 1585 Thr Lys
Phe Cys Leu Phe Cys Phe Arg Lys Leu Ala Lys Thr Gly Lys 510 515 520
525 aag aag aaa aga g attagttata tcaaaagcct gaagtggaat gactgaaaga
1638 Lys Lys Lys Arg tgggactcct cctttatttc agcatggagg gttttaaatg
gaggatttcc tttttcctgt 1698
gacaaaacat cttttcacta cttaccttgt taagacaaaa tttattttcc agggatttaa
1758 tacgtacttt agttggaatt attctatgtc aatgattttt aagctatgaa
aaatacaatg 1818 gggggaagga tagcatttgg agatatacct aatgttaaat
gacgagttac tggatgcagc 1878 acgccaacat ggcacatgta tacatatgta
gctaacctca cgttgtgcac atgtacccta 1938 aaacttaaag tataatttaa
aaaaagcaaa gggtaccg 1976 113 530 PRT H. sapiens 113 Met Ser Leu Lys
Trp Thr Ser Val Phe Leu Leu Ile Gln Leu Ser Cys 1 5 10 15 Tyr Phe
Ser Ser Gly Ser Cys Gly Lys Val Leu Val Trp Pro Thr Glu 20 25 30
Tyr Ser His Trp Ile Asn Met Lys Thr Ile Leu Glu Glu Leu Val Gln 35
40 45 Arg Gly His Glu Val Thr Val Leu Thr Ser Ser Ala Ser Thr Leu
Val 50 55 60 Asn Ala Ser Lys Ser Ser Ala Ile Lys Leu Glu Val Tyr
Pro Thr Ser 65 70 75 80 Leu Thr Lys Asn Asp Leu Glu Asp Ser Leu Leu
Lys Ile Leu Asp Arg 85 90 95 Trp Ile Tyr Gly Val Ser Lys Asn Thr
Phe Trp Ser Tyr Phe Ser Gln 100 105 110 Leu Gln Glu Leu Cys Trp Glu
Tyr Tyr Asp Tyr Ser Asn Lys Leu Cys 115 120 125 Lys Asp Ala Val Leu
Asn Lys Lys Leu Met Met Lys Leu Gln Glu Ser 130 135 140 Lys Phe Asp
Val Ile Leu Ala Asp Ala Leu Asn Pro Cys Gly Glu Leu 145 150 155 160
Leu Ala Glu Leu Phe Asn Ile Pro Phe Leu Tyr Ser Leu Arg Phe Ser 165
170 175 Val Gly Tyr Thr Phe Glu Lys Asn Gly Gly Gly Phe Leu Phe Pro
Pro 180 185 190 Ser Tyr Val Pro Val Val Met Ser Glu Leu Ser Asp Gln
Met Ile Phe 195 200 205 Met Glu Arg Ile Lys Asn Met Ile His Met Leu
Tyr Phe Asp Phe Trp 210 215 220 Phe Gln Ile Tyr Asp Leu Lys Lys Trp
Asp Gln Phe Tyr Ser Glu Val 225 230 235 240 Leu Gly Arg Pro Thr Thr
Leu Phe Glu Thr Met Gly Lys Ala Glu Met 245 250 255 Trp Leu Ile Arg
Thr Tyr Trp Asp Phe Glu Phe Pro Arg Pro Phe Leu 260 265 270 Pro Asn
Val Asp Phe Val Gly Gly Leu His Cys Lys Pro Ala Lys Pro 275 280 285
Leu Pro Lys Glu Met Glu Glu Phe Val Gln Ser Ser Gly Glu Asn Gly 290
295 300 Ile Val Val Phe Ser Leu Gly Ser Met Ile Ser Asn Met Ser Glu
Glu 305 310 315 320 Ser Ala Asn Met Ile Ala Ser Ala Leu Ala Gln Ile
Pro Gln Lys Val 325 330 335 Leu Trp Arg Phe Asp Gly Lys Lys Pro Asn
Thr Leu Gly Ser Asn Thr 340 345 350 Arg Leu Tyr Lys Trp Leu Pro Gln
Asn Asp Leu Leu Gly His Pro Lys 355 360 365 Thr Lys Ala Phe Ile Thr
His Gly Gly Thr Asn Gly Ile Tyr Glu Ala 370 375 380 Ile Tyr His Gly
Ile Pro Met Val Gly Ile Pro Leu Phe Ala Asp Gln 385 390 395 400 His
Asp Asn Ile Ala His Met Lys Ala Lys Gly Ala Ala Leu Ser Val 405 410
415 Asp Ile Arg Thr Met Ser Ser Arg Asp Leu Leu Asn Ala Leu Lys Ser
420 425 430 Val Ile Asn Asp Pro Val Tyr Lys Glu Asn Val Met Lys Leu
Ser Arg 435 440 445 Ile His His Asp Gln Pro Met Lys Pro Leu Asp Arg
Ala Val Phe Trp 450 455 460 Ile Glu Phe Val Met Arg His Lys Gly Ala
Lys His Leu Arg Val Ala 465 470 475 480 Ala His Asn Leu Thr Trp Ile
Gln Tyr His Ser Leu Asp Val Ile Ala 485 490 495 Phe Leu Leu Ala Cys
Val Ala Thr Val Ile Phe Ile Ile Thr Lys Phe 500 505 510 Cys Leu Phe
Cys Phe Arg Lys Leu Ala Lys Thr Gly Lys Lys Lys Lys 515 520 525 Arg
Asp 530 114 2312 DNA H. sapiens exon (692)...(1425) 114 accctcctgc
tcccatctgc catgatcact ggaaaaccct catttatttt ttaaagggtc 60
cagaaaatgc taatctatag agatagaaat tagattagtg gttgcctagg gtaggatgga
120 tgcaaaattt cagagtgggg ggttagaggc tattgtatag aatcttttgg
agataatact 180 gattattgta gtgaaagtaa aattctgtga atatactagg
aaacattgaa ctgtacacac 240 taattggtga gtcatatggt atatgaatta
tgtgtcaaca aagttttaga agacattact 300 tgcaccacga tattaaaaaa
tgccgtttga gttgtataat tacttcttct ctctatgtca 360 agggcaccga
acaggcagga gcctctcact tgccactgtt cttaacagta ttataaaata 420
attacataag acaggttact tacatattct aggtcataaa aattattgct tgactagagt
480 aattgtaaac ataaaagaac accaaacaca ctaaaataaa tatgaggtca
tcaatctttt 540 gttggtctcc ttggcatgca cctattcaga ctgttagtat
tatgtattta cttcaaattt 600 tagcagttat attttaactt gattgatttt
tcctcagata taagtatgag aaatgacaga 660 aagaaacaac aactggaaaa
gaagcattgc ataagaccag gatgtctctg aaatggacgt 720 cagtctttct
gctgatacag ctcagttgtt actttagctc tggaagctgt ggaaaggtgc 780
tagtgtggcc cacagaatac agccattgga taaatatgaa gacaatcctg gaagagcttg
840 ttcagagggg tcatgaggtg actgtgttga catcttcggc ttctactctt
gtcaatgcca 900 gtaaatcatc tgctattaaa ttagaagttt atcctacatc
tttaactaaa aatgatttgg 960 aagattctct tctgaaaatt ctcgatagat
ggatatatgg tgtttcaaaa aatacatttt 1020 ggtcatattt ttcacaatta
caagaattgt gttgggaata ttatgactac agtaacaagc 1080 tctgtaaaga
tgcagttttg aataagaaac ttatgatgaa actacaagag tcaaagtttg 1140
atgtcattct ggcagatgcc cttaatccct gtggtgagct actggctgaa ctatttaaca
1200 taccctttct gtacagtctt cgattctctg ttggctacac atttgagaag
aatggtggag 1260 gatttctgtt ccctccttcc tatgtacctg ttgttatgtc
agaattaagt gatcaaatga 1320 ttttcatgga gaggataaaa aatatgatac
atatgcttta ttttgacttt tggtttcaaa 1380 tttatgatct gaagaagtgg
gaccagtttt atagtgaagt tctaggtaag tcatgtgtct 1440 aactggtgct
tattaagttc taacttttct gtgcctttga aggtgagctt atataaatat 1500
aatgtcagaa gatagtgttt ttaagggaaa ttatgaattg caaatgtaag atgatctatc
1560 agtctcaaaa atattataga atgttgacct tatagaatca gttagaaccc
tggggccatc 1620 actactacag gacacccaga gagtcataaa ccttcattgt
aaagcactaa tgatttcttt 1680 aaactatcac atatcatttt gctatacatt
ttttcatctt taaaaaaagt caatagatac 1740 ctcaagaaac atcttcatga
aggcagacac ataaatttag tatttacaca tatttctaga 1800 aaaattatca
atgcaggatt gaggaatttg tttctctttg agttcctcag tttcctcatt 1860
tagaaattaa attttgtttt tcatgtaaga aggattcctt cacagttgag taatatagtg
1920 gctctactcc agaaacagaa gcctaaaact tgagatttct aatgtttata
cattccttca 1980 ataacaggtt gacaattatt tctttcaaaa actgaaatct
tgttgaaagt gaacatctaa 2040 gttttaatct atattttatt aaactgcatc
tctccatcaa agaaaatagg ggccaaatta 2100 agggagagca catatctcta
tgtcaataaa ttctgaaaat gttttaattc tcatttgtaa 2160 atatatttat
tttaaaaatc taattatatt aagatcttac gatgaaccaa gacagtagta 2220
ggtgtaaaga tttcagtgtt gagctcaaaa aactcatggt ttactttgag aaccaaggat
2280 caagggctag cttaataaac tgtagacact ag 2312 115 1021 DNA H.
sapiens exon (413)...(565) 115 accatgatcc aatcacctgc cactgggtcc
ctccctggac acatggggat tatggggatt 60 ataattcaag atgagaggag
atttgggtgg ggacagtcaa accatattag tgacttattt 120 taataattat
ttatgattgt gaatatactg atgttacatt aaagatgtga tttcttctta 180
cagatctctg aatacattgc cttccttata tatacatatg agcaacatat gcaataaata
240 aaatctaaat tatgactata tataaatgta tttatatata ttttatcaat
gcacagacat 300 tttatatatg tttgggtatg ttattccaag tcctttcagg
aaaatacctg catattcaaa 360 taacaattct cgtgttagct accttttgtt
ttgttttgtt tttttccatc aggaagaccc 420 actacattat ttgagacaat
ggggaaagct gaaatgtggc tcattcgaac ctattgggat 480 tttgaatttc
ctcgcccatt cttaccaaat gttgattttg ttggaggact tcactgtaaa 540
ccagccaaac ccctgcctaa ggtaaatgta ttcttgtttc atttgtttgc ttgacatttt
600 cagaaggaat ggctggatat gtttctttca gagtgtttaa ctcagagtga
ggggaatatg 660 ggaggtcaaa aacaaggact tgccattaga aaatcatata
tttctgtagt atcacaagta 720 tgtgaatgtt attatcatta aagaccaaag
aggtttacta gggagatttt gaaaacaggg 780 ttggttaaag taaggccttc
attgtgccac ccaaaagata gtatgattca tttcttcaaa 840 aaatatttgt
agagtgatta atacaaacca caggtaagtg ctggattttc agagaataaa 900
ggtagcacag tttctgctcc ctcatgcctt acattgtact ttgaaagata gaataaaaac
960 aagtgaaaaa gaaaagtcta aaaagtgtta ttaaggaaag accacaatga
taaagaaata 1020 t 1021 116 480 DNA H. sapiens exon (43)...(174) 116
tgctgttgct cttttctgat agaacaaatt ctttcttcac aggaaatgga agagtttgtg
60 cagagctctg gagaaaatgg tattgtggtg ttttctctgg ggtcgatgat
cagtaacatg 120 tcagaagaaa gtgccaacat gattgcatca gcccttgccc
agatcccaca aaaggttaga 180 taaagtgcct taactgtgga tggctactaa
atgaatctgt taaactcttc aagagtccat 240 tacagaaatg ttctgcctga
aaatttaact gctatgatag ttctaattat ctcagacatc 300 tgttcaaagc
aaaaacatat atggaagatc ttaaaatcat aaagagagga gttttggttg 360
ataataacgt tggcattaat attgtgatca gaaggaaata tatttaagag gtgctagtga
420 agtttggtat tatcatggta tcgtagcatg tacatagaaa tcactaaatt
ctgccctgtc 480 117 1602 DNA H. sapiens exon (368)...(455) exon
(1295)...(1514) 117 tgagtcaagg gctgactttg aatagaatgg gaggtaggtt
tgccctaagc agcttaactt 60 ttccctttag catagagttt gggttgccaa
gatttatttt cctttcacaa tctcatgtgt 120 ctagctatta tgttagaaat
gtcattattt ctttatatac aaaattgatt ataaaagtaa 180 cgacattaaa
cgtgggtatt caacttacct caaactttta gtagttctca ttacttgaca 240
tcacttcttc ttatttcttc atcttttata tggattaact aactgattat taatctcttc
300 agaattctaa catgctatgt ttttagagtt ctattcattg aacaagatat
tttccttgcc 360 ctaacaggtt ctatggagat ttgatggcaa gaagccaaat
actttaggtt ccaatactcg 420 actgtacaag tggttacccc agaatgacct
tcttggtaag attctggaga acaaacagtg 480 aatatattag taacagcaaa
ttggagtgat aatagttcaa cataaaacaa acatatttag 540 catttattat
tggaaaacta aaaaacaaat caaatttaac tactttatat ttattttcca 600
gtcttagtat aaaaagaatg cactatagta gttggcattt tattacatac agtcacattc
660 tttatggtca gaataaaaat ctctttgttc aggtgtaatt tcctctcaca
ggttttaaat 720 aacatcctgg attttctgtc tgtctcctat ttatgcagct
ttacctctgt tctttcccct 780 actgcagggt tatttcaaca ggcactgaaa
aatagcggac acttttctat taccagtgac 840 tctacttttt atgggaataa
ataaccaatc tttatcatga taaaatgata acacatttca 900 tgatgatgca
taaccggtcc ttcctcagcc ccacctccac cctactccct gctgcctttt 960
aaaaaaaatt aaatatttta aatattttaa gtatttaaat attttttaaa tatgtaaatg
1020 tgacctcatt atttataata cttaaaagac cacgttcttg tatacccaat
cttattcttt 1080 ttttttgcac attttaattt tttaattaag aatatgcttt
ttcattttgt tcacctggca 1140 attcttctga aatttgaaaa caatttcaat
gcagttttgt gggtataatg ttacctaggg 1200 aacagttttg ctttaagttc
cttatattgt gcatttctta ttcaattctc ataccttgta 1260 attaataatt
ttgttaaaat gcatccactt ttaggtcatc ccaaaaccaa agcttttata 1320
actcatggtg gaaccaatgg catctatgag gcgatctacc atgggatccc tatggtgggc
1380 attcccttgt ttgcggatca acatgataac attgctcaca tgaaagccaa
gggagcagcc 1440 ctcagtgtgg acatcaggac catgtcaagt agagatttgc
tcaatgcatt gaagtcagtc 1500 attaatgacc ctgtgtgagt attacagttt
tgtgaccagg tggtatttat aaattatttt 1560 gtcaacagtg aatatgaatt
ttaacccgtt tttaagagac ta 1602 118 978 DNA H. sapiens exon
(326)...(978) 118 caaaaagatc attctcaaat tccatttcca ctatcttact
tatagcactt agaatggctc 60 ataatatttt ctgctccaga aaacattaac
tttcccaccg aaaattccat ttttcatttt 120 taaaggtatt tgtcagtgat
aaaactccaa tttaaaaacc aaactttctg taatgacatg 180 aattaaaaca
ttgaaatttc atgccaattc agtgacactt actttcaatc atttgtgtga 240
cacttttcaa agaccatcca tagacttgat atgcttaagc aataaattta cttttaatgt
300 tgatatcttt atatttatcc ttcagctata aagagaatgt catgaaatta
tcaagaattc 360 atcatgacca accaatgaag cccctggatc gagcagtctt
ctggattgag tttgtcatgc 420 gccacaaagg agccaagcac cttcgagtcg
cagctcacaa cctcacctgg atccagtacc 480 actctttgga tgtgatagca
ttcctgctgg cctgcgtggc aactgtgata tttatcatca 540 caaaattttg
cctgttttgt ttccgaaagc ttgccaaaac aggaaagaag aagaaaagag 600
attagttata tcaaaagcct gaagtggaat gactgaaaga tgggactcct cctttatttc
660 agcatggagg gttttaaatg gaggatttcc tttttcctgt gacaaaacat
cttttcacta 720 cttaccttgt taagacaaaa tttattttcc agggatttaa
tacgtacttt agttggaatt 780 attctatgtc aatgattttt aagctatgaa
aaatacaatg gggggaagga tagcatttgg 840 agatatacct aatgttaaat
gacgagttac tggatgcagc acgccaacat ggcacatgta 900 tacatatgta
gctaacctca cgttgtgcac atgtacccta aaacttaaag tataatttaa 960
aaaaagcaaa gggtaccg 978 119 20 DNA H. sapiens 119 catgcaccta
ttcagactgt 20 120 20 DNA H. sapiens 120 tgggtgtcct gtagtagtga 20
121 25 DNA H. sapiens 121 attgattttt cctcagatat aagta 25 122 22 DNA
H. sapiens 122 tcataatttc ccttaaaaac ac 22 123 22 DNA H. sapiens
123 atatgtttgg gtatgttatt cc 22 124 18 DNA H. sapiens 124
ccatattccc ctcactct 18 125 23 DNA H. sapiens 125 atacctgcat
attcaaataa caa 23 126 18 DNA H. sapiens 126 tatccagcca ttccttct 18
127 22 DNA H. sapiens 127 agttttgtgg gtataatgtt ac 22 128 19 DNA H.
sapiens 128 aaacgggtta aaattcata 19 129 25 DNA H. sapiens 129
tcataccttg taattaataa ttttg 25 130 20 DNA H. sapiens 130 cgggttaaaa
ttcatattca 20 131 18 DNA H. sapiens 131 tcatgccaat tcagtgac 18 132
17 DNA H. sapiens 132 accctccatg ctgaaat 17 133 21 DNA H. sapiens
133 tcaaagacca tccatagact t 21 134 19 DNA H. sapiens 134 ggagtcccat
ctttcagtc 19 135 25 DNA H. sapiens 135 attgattttt cctcagatat aagta
25 136 19 DNA H. sapiens 136 atttactggc attgacaag 19 137 25 DNA H.
sapiens 137 attgattttt cctcagatat aagta 25 138 22 DNA H. sapiens
138 tgtacagaaa gggtatgtta aa 22 139 20 DNA H. sapiens 139
aaaaatkatt tggaagattc 20 140 22 DNA H. sapiens 140 tcataatttc
ccttaaaaac ac 22 141 23 DNA H. sapiens 141 atacctgcat attcaaataa
caa 23 142 18 DNA H. sapiens 142 tatccagcca ttccttct 18 143 25 DNA
H. sapiens 143 tcataccttg taattaataa ttttg 25 144 20 DNA H. sapiens
144 cgggttaaaa ttcatattca 20 145 21 DNA H. sapiens 145 tcaaagacca
tccatagact t 21 146 19 DNA H. sapiens 146 ggagtcccat ctttcagtc 19
147 20 DNA H. sapiens 147 tgatacagct cagttgttac 20 148 20 DNA H.
sapiens 148 tgatacagct cggttgttac 20 149 20 DNA H. sapiens 149
tgttgacatc ttcggcttct 20 150 20 DNA H. sapiens 150 tgttgacatc
gtcggcttct 20 151 23 DNA H. sapiens 151 ctttaactaa aaatgatttg gaa
23 152 23 DNA H. sapiens 152 ctttaactaa aaattatttg gaa 23 153 22
DNA H. sapiens 153 tttaacatac cctttctgta ca 22 154 22 DNA H.
sapiens 154 tttaacatac cctttccgta ca 22 155 22 DNA H. sapiens 155
ttggaggact tcactgtaaa cc 22 156 22 DNA H. sapiens 156 ttggaggact
tcagtgtaaa cc 22 157 23 DNA H. sapiens 157 tatgaggcga tctaccatgg
gat 23 158 23 DNA H. sapiens 158 tatgaggcaa tctaccatgg gat 23 159
24 DNA H. sapiens 159 cccttgtttg cggatcaaca tgat 24 160 24 DNA H.
sapiens 160 cccttgtttg tggatcaaca tgat 24 161 22 DNA H. sapiens 161
aaagagaatg tcatgaaatt at 22 162 22 DNA H. sapiens 162 aaagagaata
tcatgaaatt at 22 163 21 DNA H. sapiens 163 gcttgccaaa acaggaaaga a
21 164 21 DNA H. sapiens 164 gcttgccaaa aaaggaaaga a 21
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