U.S. patent application number 09/954335 was filed with the patent office on 2003-04-10 for mild cleansing composition having stable foam.
Invention is credited to Booker, Gregory, Librizzi, Joseph J..
Application Number | 20030069148 09/954335 |
Document ID | / |
Family ID | 25461209 |
Filed Date | 2003-04-10 |
United States Patent
Application |
20030069148 |
Kind Code |
A1 |
Booker, Gregory ; et
al. |
April 10, 2003 |
Mild cleansing composition having stable foam
Abstract
A mild cleansing composition that produces a stable foam
containing at least one glycoside nonionic surfactant; at least one
betaine surfactant; and at least one amphoteric surfactant, is
disclosed. The composition is substantially free of anionic
surfactant.
Inventors: |
Booker, Gregory;
(Philadelphia, PA) ; Librizzi, Joseph J.;
(Neshanic, NJ) |
Correspondence
Address: |
AUDLEY A. CIAMPORCERO JR.
JOHNSON & JOHNSON
ONE JOHNSON & JOHNSON PLAZA
NEW BRUNSWICK
NJ
08933-7003
US
|
Family ID: |
25461209 |
Appl. No.: |
09/954335 |
Filed: |
September 17, 2001 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
|
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09954335 |
Sep 17, 2001 |
|
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09931703 |
Aug 16, 2001 |
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Current U.S.
Class: |
510/130 ;
510/470; 510/490; 510/499 |
Current CPC
Class: |
A61K 8/416 20130101;
C11D 1/90 20130101; A61K 8/0208 20130101; C11D 1/662 20130101; C11D
1/94 20130101; C11D 17/049 20130101; A61K 2800/5426 20130101; A61K
8/442 20130101; A61Q 5/02 20130101; A61Q 19/10 20130101; A61K 8/604
20130101 |
Class at
Publication: |
510/130 ;
510/470; 510/490; 510/499 |
International
Class: |
A61K 007/50; C11D
001/00 |
Claims
We claim:
1. A cleansing composition comprising: at least one glycoside
nonionic surfactant; at least one betaine surfactant; and at least
one amphoteric surfactant, wherein the composition is substantially
free of anionic surfactants.
2. The composition of claim 1 wherein the composition possesses a
low degree of ocular irritancy and yields a long-lasting stable
foam.
3. The composition according to claim 1 wherein the glycoside
nonionic surfactant is selected from coco glucoside, octyl
glucoside, decyl glucoside, lauryl glucoside, and mixtures
thereof.
4. The composition according to claim 3 wherein the amount of
glycoside non ionic surfactant ranges from about 0.1% to about 20%
by weight, based on the total weight of the composition.
5. The composition according to claim 3 wherein the amount of
glycoside non ionic surfactant ranges from about 0.5% to about 15%
by weight, based on the total weight of the composition.
6. The composition according to claim 3 wherein the amount of
glycoside nonionic surfactant ranges from about 1% to about 10% by
weight, based on the total weight of the composition.
7. The composition according to claim 1 wherein the betaine
surfactant is selected from the group consisting of alkyl betaines,
alkyl sultaines, amidoalkyl betaines, amidoalkylsultaine, and
mixtures thereof, wherein the alkyl group contains from about
C.sub.8 to about C.sub.22 carbon atoms.
8. The composition according to claim 7 wherein the betaine
surfactant is decyl betaine, lauryl hydroxysultane,
oleamidopropylhydroxysultaine, cocamidopropylbetaine, and mixtures
thereof.
9. The composition according to claim 7 wherein the amount of
betaine surfactant ranges from about 0.1% to about 20% by weight,
based on the total weight of the composition.
10. The composition according to claim 7 wherein the amount of
betaine surfactant ranges from about 0.5% to about 15% by weight,
based on the total weight of the composition.
11. The composition according to claim 1 wherein the amphoteric
surfactant is selected from the group consisting of
amphocarboxylates, alkylamidoalkylamines, alkyl substituted amino
acids, amphophosphates, carboxyalkyl alkyl polyamines, and mixtures
thereof, wherein the alkyl group contains from about C.sub.8 to
about C.sub.22 carbon atoms.
12. The composition according to claim 11, wherein the amphoteric
surfactants are selected from the group consisting of
lauroamphodiacetate, lauriminodipropionate, cocoamphopropionate,
lauroamphodipropionic acid, capryloamphohydroxypropylsulfonate, and
mixtures thereof.
13. The composition according to claim 11 wherein the amount of
amphoteric surfactant ranges from about 0.1% to about 20% by
weight, based on the total weight of the composition.
14. The composition according to claim 11 wherein the amount of
amphoteric surfactant ranges from about 0.5% to about 15% by
weight, based on the total weight of the composition.
15. The composition according to claim 13 wherein the amount of
amphoteric surfactant ranges from about 1% to about 10% by weight,
based on the total weight of the composition.
16. The composition according to claim 1 wherein the glycoside
nonionic surfactant is decyl glucoside and ranges from about 1% to
about 10% by weight, based on the total weight of the composition;
the betaine surfactant is cocamidopropylbetaine and ranges from
about 1% to about 10% by weight, based on the total weight of the
composition; and the amphoteric surfactant is lauroamphodiacetate
and ranges from about 1% to about 10% by weight, based on the total
weight of the composition.
17. The composition according to claim 1 wherein the ratio of the
glycoside nonionic surfactant to the sum of the amounts of the
amphoteric surfactant and the betaine surfactant ranges from about
1 to 4 to about 1.5 to 1.
18. The composition according to claim 1 wherein the ratio of the
amount of the betaine surfactant to the amount of the amphoteric
surfactant ranges from about 1 to 2 to about 10 to 1.
19. The composition according to claim 1 wherein the ratio of the
amount of the glycoside nonionic surfactant to betaine surfactant
to amphoteric surfactant ranges from about 1:1.3: 2.66 to about
16.5: 10:1.
20. The composition of claim 1 further comprising from about 0.01
percent to about 5 percent of a cationic conditioning polymer; from
about 0.1 percent to about 5 percent of an emollient selected from
the group consisting of a diester, a triester, or a mixture
thereof; and from about 0.1 percent to about 10 percent of a
monoester emollient.
21. The composition of claim 1 further comprising a benefit
agent.
22. The composition of claim 21, wherein the benefit agent is
selected from the group consisting of salicylic acid, lactic acid,
glycolic acid, and mixtures thereof.
23. The composition of claim 21, wherein the benefit agent is
selected from the group consisting of benzethonium chloride,
benzalkonium chloride, and mixtures thereof.
24. The use of the composition of claim 1 with an implement
selected from the group consisting of a wipe, a washcloth, a mesh
or apertured film, pouf, sponge, and a brush.
25. A kit comprised of the composition of claim 1 and an implement
selected from the group consisting of a wipe, a washcloth, a mesh
or apertured film, pouf, sponge, and a brush.
26. The kit of claim 25 wherein the composition possesses a low
degree of ocular irritancy and yields a long-lasting stable foam.
Description
CROSS-REFERENCE TO RELATED APPLICATION
[0001] This Application is a continuation-in-part application of
U.S. application Ser. No. 09/931,703 filed on Aug. 16, 2001, which
is incorporated herein by reference in its entirety.
BACKGROUND OF THE INVENTION
[0002] 1. Field of the Invention
[0003] The present invention relates to a skin and hair cleansing
composition capable of producing stable foam and having a low
degree of ocular and skin irritation. More specifically, this
invention is related to such compositions having a mixture of a
betaine surfactant, an amphoteric surfactant, and a nonionic
surfactant. The compositions are substantially free of anionic
surfactants.
[0004] 2. Description of the Prior Art
[0005] It is well known that many surfactants used in shampoos and
cleansing compositions are irritating to the eyes, which is of
particular concern in shampoos and cleansing compositions used on
infants and children. As a result, several less irritating
surfactants have been developed.
[0006] Foam is a critical property of cleansing compositions,
especially personal care products such as shampoos, body washes,
hand cleansers, and facial washes. Foam quality and quantity is an
important cue to the consumer that the product is an efficacious,
quality product. Foam also serves a functional property in that it
helps emulsify dirt and oil from the skin and hair and carries the
emulsified dirt away.
[0007] Surfactants, especially anionic surfactants, are the primary
foaming ingredients found in cleansing compositions today. Anionic
surfactants, such as sulfates, sulfonates, isethionates,
sulfosuccinates, and taurates, are known for providing large
quantities of very stable foam. However, anionic surfactants are
not without their drawbacks. For example, anionic surfactants may
strip skin and hair of their natural oils, which thereby damages
hair and leaves skin dry and compromised. Anionic surfactants are
also known as irritants to the skin and eyes. For these reasons,
compositions containing anionic surfactants may be unsuitable for
baby products or for products intended for people with damaged or
sensitive skin.
[0008] Additionally, anionic surfactants are often prone to
hydrolysis, which renders them unsuitable for use in a low pH
environment. Furthermore, anionic surfactants may be incompatible
with cationic ingredients, which thereby renders them unsuitable
for a number of applications.
[0009] Alternative surfactants that have been used to minimize the
deleterious effects of anionic surfactants include both amphoteric
and nonionic surfactants. However, although such surfactants do not
possess the above negative properties associated with anionic
surfactants, they disadvantageously tend to generate poor, unstable
foam relative to that generated by anionic surfactants. This is one
reason as to why they are not widely used as primary foaming
agents. But see Patent Cooperation Treaty Patent Application No. WO
97147171 foaming systems consisting of an alkylpolyglucoside
nonionic surfactant and an amphoteric surfactant). Although such
amphoteric-non ionic systems are capable of generating foam, that
foam is not stable, i.e. long-lasting.
[0010] Therefore, there is a need for a cleansing composition based
on amphoteric and nonionic surfactants that provides a large
quantity of stable, dense foam, but which does not possess the
known deleterious effects associated with anionic surfactants.
SUMMARY OF THE INVENTION
[0011] The present invention provides a mild cleansing composition
capable of producing a stable foam comprising, consisting
essentially of, and/or consisting of: at least one glycoside
nonionic surfactant; at least one betaine surfactant; and at least
one amphoteric surfactant, wherein the composition is substantially
free of anionic surfactant.
[0012] We have unexpectedly found that the cleansing compositions
of the present invention are not only effective in providing a
superior stable foam, but do so with a low degree of skin and
ocular irritation.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENT
[0013] The first component of the compositions of the present
invention is at least one glycoside nonionic surfactant. Glycosides
are nonionic surfactants that have a hydrophobic group containing
about 6 to about 30 carbon atoms and a polysaccharide
(polyglycoside) hydrophilic group containing about 1 to about 10
saccharide units. Suitable glycosides include, but are not limited
to, coco glucoside, octyl glucoside, decyl glucoside, lauryl
glucoside, and mixtures thereof. The amount of glycoside in the
compositions of the present invention may range from about 0.1% to
about 20%, e.g. from about 0.5% to about 15% or from about 1.0% to
about 10% by weight, based on the total weight of the
composition.
[0014] The second component of the compositions of the present
invention is at least one betaine surfactant. As used herein,
betaines are typically either cationic at low pH, i.e., at about 4
or less, or isoelectric at intermediate pH, e.g. at about 7.
Suitable betaine surfactants include, but are not limited to, alkyl
betaines such as decyl betaine, alkyl sultaine such as lauryl
hydroxysultane, amidoalkyl betaines such as cocamidopropylbetaine,
amidoalkylsultaine such as oleamidopropylhydroxysultaine, and
mixtures thereof, wherein the alkyl group contains from about
C.sub.8 to about C.sub.22 carbon atoms. The amount of betaine
surfactant in the compositions of the present invention may range
from about 0.1% to about 20%, e.g. from about 0.5% to about 15% or
from about 1.0% to about 10% by weight, based on the total weight
of the composition.
[0015] The third component of the compositions of the present
invention is at least one amphoteric surfactant, which may exist in
three different forms depending upon pH: cationic at low pH, i.e.
at about 4 or less, zwitterionic at intermediate pH, i.e. at about
7, and anionic at high pH, i.e. at about 10 or higher. Suitable
amphoteric surfactants include, but are not limited to,
amphocarboxylates, alkylamidoalkylamine, alkyl substituted amino
acids, amphophosphates, carboxyalkyl alkyl polyamines, and mixtures
thereof, wherein the alkyl group contains from about C.sub.8 to
about C.sub.22 carbon atoms. Particularly suitable amphoteric
surfactants include, but are not limited to, lauroamphodiacetate,
lauriminodipropionate, cocoamphopropionate, lauroamphodipropionic
acid, capryloamphohydroxypropylsulfonate, and mixtures thereof. The
amount of amphoteric surfactant in the compositions of the present
invention may range from about 0.1% to about 20%, e.g. from about
0.5% to about 15% or from about 1.0% to about 10% by weight, based
on the total weight of the composition.
[0016] The amphoteric surfactants are disclosed herein without a
counter ion. One skilled in the art would readily recognize that
under the pH conditions of the compositions of the present
invention, the amphoteric surfactants are either electrically
neutral by virtue of having balancing positive and negative
charges, or they have counter ions such as, but not limited to,
alkali metal, alkaline earth, or ammonium counter ions.
[0017] The ratio of the amount of the glycoside nonionic surfactant
to the sum of the amounts of the amphoteric surfactant and the
betaine surfactant may range from about 1 to 4 to about 1.5 to 1.
The ratio of the amount of the betaine surfactant to the amount of
the amphoteric surfactant may range from about 1 to 2 to about 10
to 1. The ratio of glycoside nonionic surfactant to betaine
surfactant to amphoteric surfactant may range from about 1:1.3
:2.66 to about 16.5: 10:1, respectively.
[0018] The compositions of the present invention are substantially
free of anionic surfactant. As used herein, "substantially free" of
anionic surfactant means that the compositions contain less than
about 1 percent, e.g. less than about 0.5 percent or less than
about 0.1 percent by weight anionic surfactant, based on the total
weight of the composition. The term "anionic surfactant", as used
herein, means a negatively charged surfactant, and includes but is
not limited to sulfates, sulfonates, isethionates, sulfosuccinates,
taurates, and mixtures thereof.
[0019] Additional surfactants may be useful in the compositions of
the present invention in an amount, based upon the total weight of
the compositions, from about 0.5 percent to about 5 percent. One
class of nonionic surfactants useful in the present invention are
polyoxyethylene derivatives of polyol esters, wherein the
polyoxyethylene derivative of polyol ester (1) is derived from (a)
a fatty acid containing from about 8 to about 22, and preferably
from about 10 to about 14 carbon atoms, and (b) a polyol selected
from sorbitol, sorbitan, glucose, .alpha.-methyl glucoside,
polyglucose having an average of about 1 to about 3 glucose
residues per molecule, glycerine, pentaerythritol and mixtures
thereof, (2) contains an average of from about 10 to about 120, and
preferably about 20 to about 80 oxyethylene units; and (3) has an
average of about 1 to about 3 fatty acid residues per mole of
polyoxyethylene derivative of polyol ester.
[0020] Examples of preferred polyoxyethylene derivatives of polyol
esters include, but are not limited to PEG-80 sorbitan laurate and
Polysorbate 20. PEG-80 sorbitan laurate, which is a sorbitan
monoester of lauric acid ethoxylated with an average of about 80
moles of ethylene oxide, is available commercially from ICI
Surfactants of Wilmington, Del. under the tradename, "Atlas
G-4280." Polysorbate 20, which is the laurate monoester of a
mixture of sorbitol and sorbitol anhydrides condensed with
approximately 20 moles of ethylene oxide, is available commercially
from ICI Surfactants of Wilmington, Del. under the tradename "Tween
20."
[0021] Optionally, the cleansing compositions of this invention may
also contain, based upon the total weight of the cleansing
composition, from about 0.01 percent to about 1.0 percent, e.g.
from about 0.01 percent to about 0.5 percent or from about 0.01 to
about 0.2 percent of at least one primary conditioning agent.
[0022] Suitable primary conditioning agents include, but are not
limited to those cationic conditioning polymers having a high
molecular weight ranging from about 2,000 to about 5,000,000, e.g.
from about 5,000 to about 3,000,000 or from about 100,000 to about
1,000,000.
[0023] Representative classes of such suitable cationic
conditioning polymers include, but are not limited to cationic
polysaccharides; cationic homopolymers and copolymers derived from
acrylic and or methacrylic acid; cationic cellulose resins;
cationic copolymers of dimethyldiallylammonium chloride and
acrylamide and/or acrylic acid; cationic homopolymers of
dimethyldiallylammonium chloride; cationic polyalkylene and
ethoxypolyalkylene imines; quaternized silicones and copolymers and
mixtures thereof. For example, such cationic polymers include the
cationic guar gums such as guar hydroxypropyltrimonium chloride,
which is commercially available from Rhodia Incorporated, under the
tradename, "Jaguar C 17;" quaternized hydroxy ethyl cellulose
ethers such as polyquaternium 10, which are commercially available
from Amerchol Corporation under the tradename, "Ucare Polymer JR
400;" copolymers of acrylamide and dimethyldiallylammonium chloride
ethers, which are also known as polyquaternium 7 and are
commercially available from the Mcintyre Group Ltd. under the
tradename, "Mackernium 007" or from Allied Colloids under the
tradename "Salcare SC10;" copolymers of vinylpyrrolidone and
quaternized branched vinylpyrrolidone, which are commercially
available from BASF Corporation under the tradename, "Luviquat
Care;" Polyquaternium-6, which is available commercially from
Allied Colloids under the tradename, "Salcare SC30;" and copolymers
and mixtures thereof.
[0024] In one embodiment, the primary conditioner agent comprises,
consists of, or consists essentially of, based upon the overall
weight of the cleansing composition, from about 0.01 percent to
about 0.5 percent, e.g. from about 0.01 percent to about 0.2
percent, cationic guar derivative and from about 0.01 percent to
about 0.5 percent, e.g. from about 0.01 percent to about 0.2
percent, of a homopolymer or copolymer of diallyldimethylammonium
chloride.
[0025] In another embodiment, the primary conditioning agent
comprises, consists of, and/or consists essentially of, based upon
the total weight of the composition, from about 0.01 percent to
about 5 percent, e.g. from about 0.01 percent to about 3 percent or
from about 0.01 percent to about 2 percent of a cationic
conditioning polymer; from about 0.1 percent to about 5 percent,
e.g. from about 0.5 percent to about 3 percent, or from about 0.1
percent to about 2.5 percent of an emollient selected from the
group consisting of a diester, a triester, or a mixture thereof;
and from about 0.1 percent to about 10 percent, e.g. from about 0.5
percent to about 5 percent or from about 0.75 percent to about 3
percent of a monoester emollient.
[0026] Suitable diester or triester emollients may be made via the
known reaction of fatty alkoxylated esters with a straight,
branched or aromatic polyol or poly acid to form a diester or
triester of a straight, branched or aromatic polyol or poly acid.
The diester or triester reactant is comprised of two or three fatty
alkoxylated moieties, respectively, having the structure set forth
in formula I.: 1
[0027] wherein:
[0028] R.sub.1 is a saturated or unsaturated, substituted or
unsubstituted, straight, branched, or aromatic fatty moiety having
a carbon chain length of from about 6 to about 30 atoms; and
[0029] Each x and y are independently zero or an integer from 1 to
200, inclusive, with the proviso that the sum of x and y in each
fatty alkoxylated moiety is independently between 1 and 300,
inclusive, and the sum of all xs and ys in the diester or triester
does not exceed 800.
[0030] The straight, branched, or aromatic polyol or polyacid is of
the formula set forth in structure II.: 2
[0031] Wherein:
[0032] M.sub.1, M.sub.2, and M.sub.3 are independently a hydroxy,
two single bonded hydrogens, or a double bonded oxygen;
[0033] Z.sub.p, Z.sub.q, and Z.sub.r are independently hydrogen or
a hydroxy;
[0034] p, q, and r are independently zero or one, with the proviso
that the sum of p+q+r is at least 2; and
[0035] w is zero or an integer between 1 and 20, inclusive.
[0036] One suitable diester is Di-PPG-2 Myreth-10 Adipate, which is
commercially available from Croda, Incorporated under the
tradename, "Cromollient SCE," and has the structure set forth in
formula III.: 3
[0037] Monoester emollients suitable for use in the present
invention include the esters made via the known reaction of a
straight, branched or aromatic fatty acid having from about 4
carbon atoms to about 30 carbon atoms with a straight, branched or
aromatic monohydric or polyhydric alcohol. If desired, the
monohydric or polyhydric alcohol may be alkoxylated using known
methods to improve its water solubility. The resulting monoester is
of the structure set forth in formula IV.: 4
[0038] Wherein:
[0039] R.sub.2 is a saturated or unsaturated, substituted or
unsubstituted straight, branched, or aromatic fatty moiety having a
carbon chain length of from about 4 to about 30 atoms;
[0040] R.sub.3 is a saturated or unsaturated, substituted or
unsubstituted, straight, branched, or aromatic monohydric or
polyhydric alcohol having a carbon chain length from about 3 atoms
to about 30 atoms; and
[0041] Each e, f, s, and t are independently zero or integers from
1 to 100, inclusive, with the provisos that the sum of e and f is
zero or an integer between 1 and 200, inclusive, that the sum of s
and t is zero or an integer between 1 and 200, inclusive, and that
the sum of e, f, s, and t does not exceed 400.
[0042] Examples of monoesters suitable for use in the present
invention include the glyceryl esters, such as glyceryl oleate,
which is commercially available from the Goldschmidt Chemical
Corporation under the tradename, "Tegin O;" PEG-7 Glyceryl Cocoate,
which is commercially available from Croda Incorporated under the
tradename, "Glycerox HE;" and mixtures thereof.
[0043] In one embodiment, the HLB value of one or more of the
di-/tri-ester emollients and monoester emollients is less than
about 11, e.g. from about 2 to about 11 or from about 4 to about
11. In another embodiment, all of the di-tri-ester emollients and
the monoester emollients have an HLB value of less than about 11,
e.g. from about 2 to about 11 or from about 4 to about 11.
[0044] The cleansing composition of the present invention may
optionally include a chelating agent. Examples of suitable
chelating agents include those which are capable of protecting and
preserving the compositions of this invention. Preferably, the
chelating agent is EDTA, and more preferably is tetrasodium EDTA,
available commercially from Dow Chemical Company of Midland, Mich.
under the tradename, "Versene 100XL" and is present in an amount,
based upon the total weight of the composition, from about 0 to
about 0.5 percent, e.g. from about 0.05 percent to about 0.25
percent.
[0045] The cleansing compositions of the present invention may
optionally include a preservative. Suitable preservatives include,
but are not limited to, Quaternium-15, available commercially as
"Dowicil 200" from the Dow Chemical Corporation of Midland, Mich.,
and benzalkoniuni chloride and are present in the composition in an
amount, based upon the total weight of the composition, from about
0 to about 0.2 percent, e.g. from about 0.05 percent to about 0.10
percent.
[0046] Optionally, a benefit agent may be included in the
composition of the present invention. By "benefit agent," it is
mean any active ingredient that is to be delivered into and/or onto
the skin at a desired location, such as a cosmetic agent or a
pharmaceutical agent. By "cosmetic agent," it is meant any
ingredient that is appropriate for cosmetically treating, providing
nutrients to, and/or conditioning the hair and/or skin via topical
application. By "pharmaceutical agent," it is mean any drug that is
either hydrophobic or hydrophilic in nature and appropriate for
topical use. As used herein "medicament agents" include those
agents capable of promoting recovery from injury and illness.
[0047] Examples of suitable benefit agents include, but are not
limited to, depigmentation agents; reflectants; thickening agents;
detangling/wet combing agents; film forming polymers; humectants;
amino acid agents; antimicrobial agents; allergy inhibitors;
anti-acne agents; anti-aging agents; anti-wrinkling agents,
antiseptics; analgesics; antitussives; antipruritics; local
anesthetics; anti-hair loss agents; hair growth promoting agents;
hair growth inhibitor agents, antihistamines; antinfectives;
inflammation inhibitors; anti-emetics; anticholinergics;
vasoconstrictors; vasodilators; wound healing promoters; peptides,
polypeptides and proteins; deodorants and antiperspirants;
medicament agents; skin emollients and skin moisturizers; vitamins;
tanning agents; skin lightening agents; antifungals such as
antifungals for foot preparations; depilating agents; shaving
preparations; external analgesics; perfumes; counterirritants;
hemorrhoidals; insecticides; poison ivy products; poison oak
products; burn products; anti-diaper rash agents; prickly heat
agents; make-up preparations; vitamins; amino acids and their
derivatives; herbal extracts; retinoids; flavoids; sensates;
anti-oxidants; secondary hair and/or skin conditioners; pearlescent
agents; hair lighteners; chelating agents; cell turnover enhancers;
coloring agents; pigments; sunscreens and the like, and mixtures
thereof.
[0048] Commercially available pearlescent or opacifying agents
which are capable of suspending water insoluble additives such as
silicones and/or which tend to indicate to consumers that the
resultant product is a conditioning shampoo are suitable for use in
this invention. The pearlescent or opacifying agent is present in
an amount, based upon the total weight of the composition, of from
about 1 percent to about 10 percent, preferably from about 1.5
percent to about 7 percent, and more preferably, from about 2
percent to about 5 percent. Examples of suitable pearlescent or
opacifying agents include, but are not limited to mono or diesters
of (a) fatty acids having from about 16 to about 22 carbon atoms
and (b) either ethylene or propylene glycol; mono or diesters of
(a) fatty acids having from about 16 to about 22 carbon atoms (b) a
polyalkylene glycol of the formula: HO--(JO).sub.a--H, wherein J is
an alkylene group having from about 2 to about 3 carbon atoms; and
a is 2 or 3; fatty alcohols containing from about 16 to about 22
carbon atoms; fatty esters of the formula: KCOOCH.sub.2L, wherein K
and L independently contain from about 15 to about 21 carbon atoms;
inorganic solids insoluble in the shampoo composition, and mixtures
thereof.
[0049] Examples of suitable reflectants nonexclusively include
mica, alumina, calcium silicate, glycol dioleate, glycol
distearate, silica, sodium magnesium fluorosilicate, and mixtures
thereof.
[0050] Examples of suitable UV absorbers include benzophenone,
bornelone, butyl paba, cinnamidopropyl trimethyl ammonium chloride,
disodium distyrylbiphenyl disulfonate, paba, potassium
methoxycinnamate, and mixtures thereof.
[0051] Commercially available thickening agents that are capable of
imparting the appropriate viscosity to the compositions are
suitable for use in this invention. If used, the thickener should
be present in the shampoo compositions in an amount sufficient to
raise the Brookfield viscosity of the composition to a value of
between about 500 to about 10,000 centipoise. Examples of suitable
thickening agents nonexclusively include: mono or diesters of
polyethylene glycol of formula V.
HO--(CH.sub.2CH.sub.2O).sub.zH V.
[0052] wherein z is an integer from about 3 to about 200;
[0053] fatty acids containing from about 16 to about 22 carbon
atoms; fatty acid esters of ethoxylated polyols; ethoxylated
derivatives of mono and diesters of fatty acids and glycerine;
hydroxyalkyl cellulose; alkyl cellulose; hydroxyalkyl alkyl
cellulose; and mixtures thereof. More specifically, suitable
thickening agents nonexclusively include behenalkonium chloride;
cetyl alcohol, quaternium 46, PG-hydroxyethyl cellulose,
cocodimonium chloride, polyquaternium 6, polyquaternium 7,
quaternium 18, PEG-18 glycerol oleate/cocoate, a mixture of
acrylates/spirit 50 acrylate copolymer, laureth 3 and propylene
glycol, which is commercially available from Goldschmidt under the
tradename "Antil 208," a mixture of cocamidopropylbetaine and
glyceryl laurate which is commercially available from Goldschmidt
under the tradename, "Antil HS60," a mixture of propylene glycol,
PEG 55, and propylene glycol oleate, which is commercially
available from Goldschmidt under the tradename, "Antil 414 liquid,"
PEG-150 distearate which is available from the Stepan Company of
Northfield, Ill. or from Comiel, S.p.A. of Bologna, Italy under the
tradename, "PEG 6000 DS", and mixtures thereof.
[0054] Suitable detangling/wet combing agents nonexclusively
include dioleoylamidoethyl hydroxythylmonium methosulfate, di
(soyoylethyl) hydroxyethylmonium methosulfate, hydroxyethyl
behenamidopropyl dimonium chloride, olealkonium chloride,
polyquaternium 47, stearalkonium chloride, tricetylmonium chloride,
and mixtures thereof.
[0055] Suitable film forming polymers include those that, upon
drying, produce a substantially continuous coating or film on the
hair, skin, or nails. Nonexclusive examples of suitable film
forming polymers include acrylamidopropyl trimonium
chloride/acrylamide copolymer; corn starch/acrylamide/sodium
acrylate copolymer; polyquaternium 10; polyquaternium 47;
polyvinylmethyl/maleic anhydride copolymer; styrene/acrylates
copolymers; and mixtures thereof.
[0056] Commercially available humectants which are capable of
providing moisturization and conditioning properties to the
cleansing composition are suitable for use in the present
invention. The humectant is preferably present in an amount of from
about 0 percent to about 10 percent, more preferably from about 1.5
percent to about 7 percent, and most preferably from about 2
percent to about 5 percent, based on the overall weight of the
composition. Examples of suitable humectants nonexclusively
include: 1) water soluble liquid polyols selected from the group
comprising glycerine, propylene glycol, hexylene glycol, butylene
glycol, pentylene glycol, dipropylene glycol, and mixtures thereof;
2) polyalkylene glycol of the formula VI:
HO--(R"O).sub.b--H VI.
[0057] wherein R" is an alkylene group having from about 2 to about
4 carbon atoms and b is an integer of from about 1 to about 10,
such as PEG 4; 3) polyethylene glycol ether of methyl glucose of
formula VII:
CH.sub.3--C.sub.6H.sub.10O.sub.5--(OCH.sub.2CH.sub.2).sub.c--OH
VII.
[0058] wherein c is an integer from about 5 to about 25:
[0059] 4) urea; 5) fructose; 6) glucose; 7) honey; 8) lactic acid;
9) maltose; 10) sodium glucuronate; and 11) mixtures thereof.
[0060] Suitable amino acid agents include amino acids derived from
the hydrolysis of various proteins as well as the salts, esters,
and acyl derivatives thereof. Examples of such amino acid agents
nonexclusively include amphoteric amino acids such as alkylamido
alkylamines, i.e. stearyl acetyl glutamate, capryloyl silk amino
acid, caprylol collagen amino acids; capryloyl kertain amino acids;
capryloyl pea amino acids; cocodimonium hydroxypropyl silk amino
acids; corn gluten amino acids; cysteine; glutamic acid; glycine;
hair keratin amino acids; hair amino acids such as aspartic acid,
threonine, serine, glutamic acid, proline, glycine, alanine,
half-cystine, valine, methionine, isoleucine, leucine, tyrosine,
phenylalanine, cysteic acid, lysine, histidine, arginine, cysteine,
tryptophan, citrulline; lysine; silk amino acids, wheat amino
acids; and mixtures thereof.
[0061] Suitable proteins include those polymers that have a long
chain, i.e. at least about 10 carbon atoms, and a high molecular
weight, i.e. at least about 1000, and are formed by
self-condensation of amino acids. Nonexclusive examples of such
proteins include collagen, deoxyribonuclease, iodized corn protein;
keratin; milk protein; protease; serum protein; silk; sweet almond
protein; wheat germ protein; wheat protein; wheat protein, alpha
and beta helix of keratin proteins; hair proteins, such as
intermediate filament proteins, high-sulfur proteins,
ultrahigh-sulfur proteins, Intermediate filament-associated
proteins, high-tyrosine proteins, high-glycine tyrosine proteins,
tricohyalin, and mixtures thereof.
[0062] Examples of suitable vitamins nonexclusively include vitamin
B complex; including thiamine, nicotinic acid, biotin, pantothenic
acid, choline, riboflavin, vitamin B6, vitamin B 12, pyridoxine,
inositol, carnitine; vitamins A,C,D,E,K and their derivatives such
as vitamin A palmitate and pro-vitamins, e.g. (i.e. panthenol (pro
vitamin B5) and panthenol triacetate) and mixtures thereof.
[0063] Examples of suitable antibacterial agents nonexclusively
include bacitracin, erythromycin, neomycin, tetracycline,
chlortetracycline, quaternary ammonium agents such as benzethonium
chloride and benzalkonium chloride, phenol, and mixtures
thereof
[0064] Examples of suitable skin emollients and skin moisturizers
nonexclusively include mineral oil, lanolin, vegetable oils,
isostearyl isostearate, glyceryl laurate, methyl gluceth 10, methyl
gluceth 20 chitosan, and mixtures thereof.
[0065] Examples of suitable secondary hair conditioners
nonexclusively volatile silicones. When used, the volatile silicone
conditioning agent preferably has an atmospheric pressure boiling
point less than about 220.degree. C. The volatile silicone
conditioner is present in an amount of from about 0 percent to
about 3 percent, e.g. from about 0.25 percent to about 2.5 percent
or from about 0.5 percent to about 1.0 percent, based on the
overall weight of the composition. Examples of suitable volatile
silicones nonexclusively include polydimethylsiloxane,
polydimethylcyclosiloxane, hexamethyidisiloxane, cyclomethicone
fluids such as polydimethylcyclosiloxane available commercially
from Dow Corning Corporation of Midland, Mich. under the tradename,
"DC-345" and mixtures thereof.
[0066] Examples of suitable hair moisturizers nonexclusively
include panthenyl ethyl ether, phytantriol, and mixtures thereof.
Examples of sunscreen agents nonexclusively include butyl
methoxydibenzoylmethane, octyl methoxycinnamate, oxybenzone,
octocrylene, octyl salicylate, phenylbenzimidazole sulfonic acid,
ethyl hydroxypropyl aminobenzoate, menthyl anthranilate,
aminobenzoic acid, cinoxate, diethanolamine methoxycinnamate,
glyceryl aminobenzoate, titanium dioxide, zinc oxide, oxybenzone,
padimate o, red petrolatum, and mixtures thereof.
[0067] An example of a suitable tanning agent nonexclusively
includes dihydroxyacetone.
[0068] Examples of skin lightening agents nonexclusively include
hydroquinone, catechol and its derivatives, ascorbic acid and its
derivatives, and mixtures thereof.
[0069] Examples of suitable insecticides (including insect
repellents, anti-scabies and anti-lice treatments) nonexclusively
include permethrin, pyrethrin, piperonyl butoxide, imidacloprid,
N,N-diethyl toluamide, which refers to the material containing
predominantly the meta isomer, i.e., N,N-diethyl-m-toluamide, which
is also known as DEET; compounds of the formula VIII. 5
[0070] wherein
[0071] R.sub.5 is a branched or unbranched alkyl group having about
1 to about 6 carbon atoms;
[0072] R.sub.6 is H, methyl or ethyl;
[0073] R.sub.7 is a branched or unbranched alkyl or alkoxy group
having from about 1 to about 8 carbon atoms; and
[0074] K is a --CN or a --COOR.sub.8 group, wherein
[0075] R.sub.8 is a branched or unbranched alkyl group having from
about 1 to about 6 carbon atoms,
[0076] natural or synthetic pyrethroids, whereby the natural
pyrethroids are contained in pyrethrum, the extract of the ground
flowers of Chrysanthemum cinerariaefolium or C coccineum; and
mixtures thereof. Within the structure of Formula VIII. are ethyl
3-(N-butylacetamido)propi- onate, wherein R.sub.7 is a CH.sub.3
group, R.sub.5 is an n-butyl group, R.sub.6 is H, K is COOR.sub.8
and R.sub.8 is ethyl, which is available commercially from Merck
KGaA of Darmstadt, Germany under the name, "Insect Repellent
3535."
[0077] An example of an anti fungal for foot preparations
nonexclusively includes tolnaftate.
[0078] Examples of suitable depilating agents nonexclusively
include calcium thioglycolate, magnesium thioglycolate, potassium
thioglycolate, strontium thioglycolate, and mixtures thereof.
[0079] Examples of suitable external analgesics and local
anesthetics nonexclusively include benzocaine, dibucaine, benzyl
alcohol, camphor, capsaicin, capsicum, capsicum oleoresin, juniper
tar, menthol, methyl nicotinate, methyl salicylate, phenol,
resorcinol, turpentine oil, and mixtures thereof.
[0080] Examples or suitable antiperspirants and deodorants
nonexclusively include aluminum chlorohydrates, aluminium zirconium
chlorohydrates, and mixtures thereof.
[0081] Examples of suitable counterirritants nonexclusively include
camphor, menthol, methyl salicylate, peppermint and clove oils,
ichtammol, and mixtures thereof.
[0082] An example of a suitable inflammation inhibitor
nonexclusively includes hydrocortisone.
[0083] Examples of suitable hemorrhoidal products nonexclusively
include the anesthetics such as benzocaine, pramoxine
hydrochloride, and mixtures thereof; antiseptics such as
benzethonium chloride; astringents such as zinc oxide, bismuth
subgallate, balsam Peru, and mixtures thereof; skin protectants
such as cod liver oil, vegetable oil, and mixtures thereof.
[0084] Examples of suitable make-up preparations nonexclusively
include components for lipstick, rouge, blush, eye liner, eyeshadow
powder, mascara, face powder, and mixtures thereof.
[0085] As used herein, "hair loss treatment agents" shall include
agents capable of growing hair and/or agents capable of preventing
the loss of hair. By "effective amount," it is meant an amount
effective for treating hair loss and may range from, based upon the
total weight of the cleansing composition, from about 0.001 percent
to about 20 percent, e.g., preferably from about 1 percent to about
5 percent. Examples of benefit agents suitable for treating hair
loss include, but are not limited to potassium channel openers or
peripheral vasodilators such as minoxidil, diazoxide, and compounds
such as N*-cyano-N-(tert-pentyl)-N'-3- -pyridinyl-guanidine
("P-1075") as disclosed in U.S. Pat. No. 5,244,664, which is
incorporated herein by reference; vitamins, such as vitamin E and
vitamin C, and derivatives thereof such as vitamin E acetate and
vitamin C palmitate; honnones, such as erythropoietin,
prostaglandins, such as prostaglandin EI and prostaglandin
F2-alpha; fatty acids, such as oleic acid; diruretics such as
spironolactone; heat shock proteins ("HSP"), such as HSP 27 and HSP
72; calcium channel blockers, such as verapamil HCL, nifedipine,
and diltiazemamiloride; immunosuppressant drugs, such as
cyclosporin and Fk-506; 5 alpha-reductase inhibitors such as
finasteride; growth factors such as, EGF, IGF and FGF; transforming
growth factor beta; tumor necrosis factor; non-steroidal
anti-inflammatory agents such as benoxaprofen; retinoids such as
tretinoin; cytokines, such as IL-6, IL-1 alpha, and IL-1 beta; cell
adhesion molecules such as ICAM; glucorcorticoids such as
betametasone; botanical extracts such as aloe, clove, ginseng,
rehmannia, swertia, sweet orange, zanthoxylum, Serenoa repens (saw
palmetto), Hypoxis rooperi, stinging nettle, pumpkin seeds, and rye
pollen; other botanical extracts including sandlewood, red beet
root, chrysanthemum, rosemary, burdock root and other hair growth
promoter activators which are disclosed in DE 4330597 which is
incorporated by reference in its entirety herein; homeopathic
agents such as Kalium Phosphoricum D2, Azadirachta indica D2, and
Joborandi DI; genes for cytokines, growth factors, and
male-pattered baldness; antifungals such as ketoconazole and
elubiol; antibiotics such as streptomycin; proteins inhibitors such
as cycloheximide; acetazolamide; benoxaprofen; cortisone;
diltiazem; hexachlorobenzene; hydantoin; nifedipine; penicillamine;
phenothaiazines; pinacidil; psoralens, verapamil;
[0086] zidovudine; alpha-glucosylated rutin having at least one of
the following rutins: quercetin, isoquercitrin, hespeddin,
naringin, and methylhesperidin, and flavonoids and
transglycosidated derivatives thereof which are all disclosed in JP
7002677, which is incorporated by reference in its entirety herein;
and mixtures thereof.
[0087] Examples of benefit agents suitable for use in inhibiting
hair growth include: serine proteases such as trypsin; vitamins
such as alpha-tocophenol (vitamin E) and derivatives thereof such
as tocophenol acetate and tocophenol palmitate; antineoplastic
agents, such as doxorubicin, cyclophosphamide, chlormethine,
methotrexate, fluorouracil, vincristine, daunorubicin, bleomycin
and hydroxycarbamide; anticoagulants, such as heparin, heparinoids,
coumaerins, detran and indandiones; antithyroid drugs, such as
iodine, thiouracils and carbimazole; lithium and lithium carbonate;
interferons, such as interferon alpha, interferon alpha-2a and
interferon alpha-2b; retinoids, such as retinol (vitamin A),
isotretinoin: glucocorticoids such as betamethasone, and
dexamethosone; antihyperlipidaemic drugs, such as triparanol and
clofibrate; thallium; mercury; albendazole; allopurinol;
amiodarone; amphetamines; androgens; bromocriptine; butyrophenones;
carbamazepine; cholestyramine; cimetidine; clofibrate; danazol;
desipramine; dixyrazine; ethambutol; etionamide; fluoxetine;
gentamicin, gold salts; hydantoins; ibuprofen; imipramine;
immunoglobulins; indandiones; indomethacin; intraconazole;
levadopa; maprotiline; methysergide; metoprolol; metyrapone;
nadolol; nicotinic acid; potassium thiocyanate; propranolol;
pyridostimine; salicylates; sulfasalazine; terfenadine;
thiamphenicol; thiouracils; trimethadione; troparanol; valproic
acid; and mixtures thereof. The composition may contain, based upon
the total weight of the composition, from about 0.001 percent to
about 20 percent, e.g. from about 0.01 percent to about 5 percent,
of a hair growth inhibiting agent.
[0088] Examples of suitable anti-aging agents include, but are not
limited to inorganic sunscreens such as titanium dioxide and zinc
oxide; organic sunscreens such as octyl-methyl cinnamates and
derivatives thereof; retinoids; vitamins such as vitamin E, vitamin
A, vitamin C, vitamin B, and derivatives thereof such as vitamin E
acetate, vitamin C palmitate, and the like; antioxidants including
beta carotene, alpha hydroxy acid such as glycolic acid, citric
acid, lactic acid, malic acid, mandelic acid, ascorbic acid,
alpha-hydroxybutyric acid, alpha-hydroxyisobutyric acid,
alpha-hydroxyisocaproic acid, atrrolactic acid,
alpha-hydroxyisovaleric acid, ethyl pyruvate, galacturonic acid,
glucopentonic acid, glucopheptono 1,4-lactone, gluconic acid,
gluconolactone, glucuronic acid, glucurronolactone, glycolic acid,
isopropyl pyruvate, methyl pyruvate, mucic acid, pyruvia acid,
saccharic acid, saccaric acid 1,4-lactone, tartaric acid, and
tartronic acid; beta hydroxy acids such as beta-hydroxybutyric
acid, beta-phenyl-lactic acid, beta-phenylpyruvic acid; botanical
extracts such as green tea, soy, milk thistle, algae, aloe,
angelica, bitter orange, coffee, goldthread, grapefruit, hoellen,
honeysuckle, Job's tears, lithospermum, mulberry, peony, puerarua,
nice, safflower, and mixtures thereof. Suitable amounts of
anti-aging agents include, based upon the total weight of the
cleansing composition, from about 0.01 percent to about 10 percent,
e.g. from about 0.04 percent to about 5 percent.
[0089] Examples of suitable anti-acne agents include, but are not
limited to topical retinoids (tretinoin, isotretinoin, motretinide,
adapalene, tazarotene, azelaic acid, retinol); salicylic acid;
benzoyl peroxide; resorcinol; antibiotics such as tetracycline and
isomers thereof, erythromycin, and the anti-inflammatory agents
such as ibuprofen, naproxen, hetprofen; botanical extracts such as
alnus, arnica, artemisia capillaris, asiasarum root, birth,
calendula, chamomile, cnidium, comfrey, fennel, galla rhois,
hawthrom, houttuynia, hypericurn, jujube, kiwi, licorice, magnolia,
olive, peppermint, philodendron, salvia, sasa albo-marginata;
imidazoles such as ketoconazole and elubiol, and those described in
Gollnick, H et al. 196(I) Dermatology Sebaceous Glands, Acne and
Related Disorders, 119-157 (1998), which is incorporated by
reference herein, and mixtures thereof. Suitable amount of
anti-acne agents may be present in an amount, based upon the total
weight of the cleansing composition, from about 0.01 percent to
about 10 percent, e.g. from about 0.04 percent to about 5
percent.
[0090] Suitable effective amounts of depigmentation agents include,
based upon the total weight of the cleansing composition, from
about 0.01 percent to about 10 percent, e.g. from about 0.04
percent to about 5 percent. Examples of suitable depigmentation
agents include, but are not limited to retinoids such as retinol;
Kojic acid and its derivatives such as, for example, kojic
dipalmitate; hydroquinone and it derivatives such as arbutin;
transexamic acid; vitamins such as niacin, vitamin C and its
derivatives; azelaic acid; placertia; licorice; extracts such as
chamomile and green tea, and mixtures thereof.
[0091] As used herein, "dandruff treatment agent," "seborrheic
dermatitis treatment agent," or a "psoriasis treatment agent,"
respectively, shall include agents capable of treating the symptoms
and/or the diseases of dandruff, seborrheic dermatitis, and
psoriasis, respectively. By "effective amount," it is meant an
amount effective for treating the disease and/or the symptoms
associated therewith and preferably may range from, based upon the
total weight of the cleansing composition, from about 0.001 percent
to about 10 percent, e.g. from about 0.01 percent to about 5
percent. Examples of agents effective in the treatment of dandruff,
seborrheic dermatitis, and psoriasis as well as the symptoms
associated therewith include, but are not limited to, zinc
pyrithione, shale oil and derivatives thereof such as sulfonated
shale oil, selenium sulfide, sulfur; salicylic acid; coal tar;
povidone-iodine, imidazoles such as ketoconazole, dichlorophenyl
imidazolodioxalan, which is commercially available from Janssen
Pharmaceutica, N.V., under the tradename, "Elubiol", clotrimazole,
itraconazole, miconazole, climbazole, tioconazole, sulconazole,
butoconazole, fluconazole, miconazolenitrite and any possible
stereo isomers and derivatives thereof such as anthralin; piroctone
olamine (Octopirox); selenium sulfide; ciclopirox olamine;
anti-psoriasis agents such as vitamin D analogs, e.g. calcipotriol,
calcitriol, and tacaleitrol; vitamin A analogs such as esters of
vitamin A, e.g. vitamin A palmitate, retinoids, retinols, and
retinoic acid; corticosteroids such as hydrocortisone, clobetasone,
butyrate, clobetasol propionate and mixtures thereof.
[0092] The amount of benefit agent to be combined with the
cleansing composition may vary depending upon, for example, the
resulting benefit desired and the sensitivity of the user to the
benefit agent. Unless otherwise expressed herein, preferably the
benefit agent is present in the cleansing composition or delivery
system in an amount, based upon the total weight of the cleansing
composition, from about 0.001 percent to about 20 percent, e.g.
from about 0.001 percent to about 10 percent or from about 0.001
percent to about 5 percent.
[0093] The mildness of each benefit agent will depend upon the
benefit agent selected and the amount of benefit agent employed.
Therefore, in general, in embodiments wherein mildness is of
particular concern, the composition may omit the incorporation of a
benefit agent or alternatively use low amount thereofs. Similarly,
the effect of the benefit agent on foam agent will depend upon the
benefit agent selected and the amount of benefit agent employed.
Therefore, in general, in embodiments wherein high foaming is of
particular concern, the composition may omit the incorporation of a
benefit agent or alternatively use low amount thereofs.
[0094] The pH of the compositions of this invention will depend
upon, for example, the benefit agent selected and the type of
product, e.g. shampoo, wash, etc., desired. However, the pH is
typcially maintained in the range of from about 3 to about 7.5,
e.g. from about 5.5 to about 7.0. For shampoo compositions, a pH of
from about 5.5 to about 7.5 is typically used. Compositions of this
invention having a pH from about 3 to about 5 are useful for
delivering many skin care benefit agents, which include but are not
limited to alpha and beta hydroxy acids such as salicylic acid,
glycolic acid, lactic acid, and mixtures thereof, to the skin.
Compositions having a pH of about 7 or higher are useful for
delivering quaternary antibacterial agents such as benzalkonium
chloride and benzethonium chloride to the skin.
[0095] The above described cleansing composition may be prepared by
combining the desired components in a suitable container and mixing
them under ambient conditions in any conventional mixing means well
known in the art, such as via mechanically stirred propeller,
paddle, and the like. Although the order of mixing is not critical,
it is preferable to pre-blend certain components, such as the
fragrance and the nonionic surfactant before adding such components
into the main mixture.
[0096] The compositions of the present invention are preferably
used in shampoos, washes, baths, gels, lotions, creams, and the
like for cleansing purposes. In one embodiment, the composition may
be incorporated into a bath fizz ball, such as those described in
U.S. Pat. Nos. 4,650,661; 4,666,707; and 4,002,758; which are
incorporated herein by reference.
[0097] The composition of the present invention may be used on the
body in conjunction with any personal cleansing implement known in
the art such as a wipe, a washcloth, a mesh or apertured film,
pouf, sponge, brush and the like. In one embodiment, the
composition may be marketed together with one or more of such
implements in a kit. The implements may be loaded with appropriate
skin care compositions and packaged as a wet implement, such as wet
wipes. The composition of the present invention may be loaded onto
the implement by dipping the implement in the composition, by
spraying the composition onto the implement, and other means known
in the art
[0098] Alternatively, the wet implement may be dried through the
use of heating equipment, vacuum driers, or other means known in
the art to provide a dry implement, such as dry wipes.
Alternatively, the composition of the present invention may be
applied in the form of a concentrate to the implement in order to
provide a dry article. These dry articles may then be sold dry with
the intent that the consumer will consequently wet the article with
water when ready for use.
[0099] The compositions of the present invention have a low degree
of ocular irritancy. By "low degree of ocular irritancy" it is
meant that the composition is not more irritating to eyes than pure
sterile water.
[0100] Several examples are set Forth below to further illustrate
the nature of the invention and the manner of carrying it out.
However, the invention should not be considered as being limited to
the details thereof.
EXAMPLES
[0101] The following test method is used in the below Examples:
[0102] Human Ocular Irritancy Test: This is a double-blinded,
randomized, two (2) cell study, with test materials being applied
once. The test material, which is a 10% dilution of a test sample
having a temperature of 37-38.degree. C., is instilled in one eye
and sterile purified water is installed in the other eye of each
panelist. Ten (10) panelists are required to complete the
study.
[0103] Following the randomized order of testing the panelists and
of assigning which material to instill and into which eye that
material shall be instilled, one (1) drop of the appropriate test
material is instilled into the first eye of the panelist followed
by instillation of the sterile water into the second eye. A new
sterile disposable eyedropper is used for each test material and
disposed of after being used on only one panelist's eye. All
instillations are performed either by an investigator or by a
trained technician. For each eye, an independent tissue is used to
blot any lacrimation that falls from that respective eye. Within 30
seconds, or as closely as possible following instillation,
panelists are asked to grade stinging sensation to their eyes
utilizing the following criteria: 0=within normal limits;1=mild,
very slight, 2=moderate, and 3=severe. At 1/4 hour and 1 hour
post-instillation, panelists are again asked to grade stinging
sensation to eyes.
Example 1
Preparation of Cleansing Compositions
[0104] Three independent sample formulations were prepared
utilizing the materials listed in Table 1:
1 TABLE 1 CTFA NAME #1* #2* #3* #4* Decyl Glucoside 3.0 3.0 3.0 3.6
Cocamidopropylbetaine 3.0 6.0 -- 4.7 Disodium 3.0 -- 6.0 0.7
Lauroamphodiacetate *expressed in terms of weight percentage
[0105] Each of the samples was independently prepared by adding the
appropriate parts of active surfactant to water such that the
resultant quantity equals 100 parts. Each solution was then stirred
until a homogenous, clear solution was obtained.
[0106] Foam stability evaluation was accomplished using an
Airspray.RTM. mini-foamer 0.4 cc pump. The pump is capable of
extruding a constant volume of liquid and allowing it to mix with
air, which therefore creates enough energy to yield a foam. With
time, the foam eventually breaks down. However, a dense, stable
foam will retain its foam structure for longer periods of time than
a loose, unstable foam. The procedure for using this foam test was
as follows:
[0107] 1) Each sample was inserted into an independent mini foamer,
which was then pumped with 1 stroke onto a porous substrate that
allowed for wicking and draining of the liquid.
[0108] 2) An initial, visual foam assessment was made on the pumped
sample, based upon a scale of 1-10. A rating of "10" indicated a
very dense, creamy, high quality foam while a "1" indicated a fully
drained, foam remnant.
[0109] 3) Periodic assessments were made of the pumped sample while
the foam gradually degraded.
[0110] The results are reported in Table 2.
2TABLE 2 Time (minutes) #1 #2 #3 #4 1 10 10 10 10 2 10 9 9 10 3 10
7 7 9 4 10 3 2 9 5 8 1 1 7 10 8 1 1 7 14 6 1 1 4 15 4 1 1 2
[0111] As can be seen from the data above, the compositions of the
present invention provided a long lasting table foam that was
dense, creamy, and of high quality. In particular, as shown in
Samples 1 and 4, the stable foam retained its approximate initial
foam height and quality, i.e. stayed white/pastel in color, was
very dense, and did not degrade, for a time longer than about 3
minutes, and such stable foam lasted over twice as long as that
produced by comparative cleansers.
Example 2
Preparation of Cleansing Composition with Conditioner
[0112] A moisturizing cleansing composition was prepared according
to the materials and amounts listed in Table 3 as follows:
3TABLE 3 Tradename/Supplier INCI Name % w/w Plantaren 2000 from
Cognis Corporation Decyl Glucoside 6.0 Lamesoft P065 from Cognis
Corporation 3.00 Water 1.05 Coco glucoside 1.05 Glyceryl oleate 0.9
PEG 6000 DS from Stepan Company PEG 150 distearate 1.4 Atlas G4280
from Uniqema POE 80 sorbitan 5.0 laurate Water Deionized water
59.67 Polymer JR from Amerchol Corporation Polyquaternium 10 0.12
Glucquat 125 from Amerchol Corporation Lauryl methyl 1.00
gluceth-10/hydroxy- propyldi-monium chloride Tegobetaine L-7 (30%)
from Goldschmidt Cocamidopropyl 12.00 Chemical Corporation betaine
Monateric 949J from Uniqema Disodium 2.00 lauroamphodiacetate
Polyox WSR-205 from Amerchol PEG 14-M 0.10 Corporation Glycerin
from Cognis Corporation Glycerin 0.50 Cromollient SCE from Croda
Inc. Di-PPG-Myreth-10- 1.00 Adipate Lipovol J from Lipo Chemicals,
Inc. Jojoba oil 0.1 Drakeol 7 from Penreco Mineral oil 0.10
Fragrance Fragrance 0.50 Dowicil 200 from Dow Chemical Quaternium
15 0.05 Company Versene 100XL from Dow Chemical Tetrasodium EDTA
0.46 Company Euperlan PK 3000 from Cognis 2.00 Corporation
Cocamidopropyl betaine Glycol distearate Laureth-4 Citric acid
(20%) Citric acid As needed
[0113] The following Pre-Mixtures were prepared:
[0114] Pre-Mixture 1: PEG-14M and glycerin were mixed in an
independent container under ambient conditions.
[0115] Pre-Mixture 2: Di-PPG-2-myreth-10-adipate, mineral oil, and
jojoba oil were mixed in an independent container under ambient
conditions.
[0116] Pre Mixture 3: The fragrance and 1 part of POE-80 sorbitan
laurate were mixed in an independent container under ambient
conditions. Component amounts in this procedure are given in terms
of parts by weight of active to prepare 100 parts of the cleansing
composition.
[0117] The decyl glucoside, cocoglucoside, and glyceryl oleate were
mixed in an independent container under ambient conditions until
the resulting solution was clear. The solution was then heated to a
temperature of about 50.degree. C. to 55.degree. C. with constant
stirring. PEG 150 distearate was added thereto with stirring at
constant temperature until the PEG 150 distearate was dissolved
therein. As the resulting solution was cooled to 40.degree. C., the
following components were added thereto sequentially with stirring,
and the solution was homogeneous before the addition of each
subsequent component: (4 parts) POE-80 sorbitan laurate; (59.67
parts) water; polyquaternium-10; lauryl methyl gluceth-10
hydroxypropyldirnonium chloride; cocamidopropylbetaine; disodium
lauroamphodiacetate; PEG-14M/glycerin pre-mix; and
Di-PPG-2-myreth-10-adipate/mineral oil/jojoba oil pre-mix.
[0118] After the resulting mixture was cooled to a temperature of
about 40.degree. C., the following components were added thereto
sequentially, and the solution was homogeneous before the addition
of each subsequent component: fragrance/POE-80 sorbitan laurate
premixture, quaternium-15, tetrasodium EDTA, glycol distearate, and
laureth-4. After sodium chloride was added thereto, the pH of the
resulting solution was adjusted with citric acid to about 6.8. The
remaining water was added thereto with stirring until the final
solution was homogeneous. The viscosity of the resulting solution
was 1300 cps as measured by a Brookfield DV-I+ Viscometer using a
#2 spindle and speed of 6 rpm.
Example 3
Ocular Irritancy Test
[0119] The human ocular sting test was performed utilizing the
composition produced in accordance with Example 2. The results of
the study are shown in Table 4.
4 TABLE 4 Sample Stinging To Eye Score Composition of Example 2 0
sterile purified water 0
[0120] This Example shows that the compositions of this invention
were found to be no more stinging to the eyes than sterile purified
water.
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