U.S. patent application number 10/102561 was filed with the patent office on 2002-10-31 for controlled release of substances.
Invention is credited to Hartvigsen, Joseph J., Joshi, Ashok V., Kassebaum, James Web, McEvoy, John J., Snyder, Daniel Earl, Winkle, Joseph Raymod, Wold, Truman C..
Application Number | 20020158156 10/102561 |
Document ID | / |
Family ID | 24589991 |
Filed Date | 2002-10-31 |
United States Patent
Application |
20020158156 |
Kind Code |
A1 |
Joshi, Ashok V. ; et
al. |
October 31, 2002 |
Controlled release of substances
Abstract
The present invention is directed to a device for releasing a
fluid. The device includes a housing having an interior region, a
fluid contained within the interior region, and the ability to
controllably release the fluid from the housing.
Inventors: |
Joshi, Ashok V.; (Salt Lake
City, UT) ; McEvoy, John J.; (Sandy, UT) ;
Wold, Truman C.; (Salt Lake City, UT) ; Hartvigsen,
Joseph J.; (Kaysville, UT) ; Snyder, Daniel Earl;
(Indianapolis, IN) ; Winkle, Joseph Raymod;
(Indianapolis, IN) ; Kassebaum, James Web;
(Indianapolis, IN) |
Correspondence
Address: |
FACTOR & PARTNERS, LLC
1327 W. WASHINGTON BLVD.
SUITE 5G/H
CHICAGO
IL
60607
US
|
Family ID: |
24589991 |
Appl. No.: |
10/102561 |
Filed: |
March 20, 2002 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
|
|
10102561 |
Mar 20, 2002 |
|
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|
09645673 |
Aug 24, 2000 |
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Current U.S.
Class: |
239/590 |
Current CPC
Class: |
A61L 9/12 20130101; A61L
9/145 20130101; A01M 1/2077 20130101; A61L 9/02 20130101; A61L
9/122 20130101; A01M 1/2072 20130101; A61L 9/03 20130101; A61L
9/048 20130101 |
Class at
Publication: |
239/590 |
International
Class: |
B05B 001/14 |
Claims
What is claimed is:
1. A device for delivering a fluid comprising: a housing having an
interior region and an opening; a quantity of fluid within the
interior of housing; means for causing a pressure differential
between the interior region of housing and the immediate
surroundings of the housing, wherein the pressure differential, in
turn, forces a predetermined quantity of fluid from within the
interior region of the housing to the opening; and means associated
with the opening for controlling the flow of fluid through the
opening.
2. The device according to claim 1 wherein the pressure
differential causing means comprises means for increasing the
temperature within the housing which, in turn, increases the
pressure of the gas within the housing.
3. The device according to claim 1 wherein the pressure
differential causing means comprises means for increasing the
barometric pressure external to the housing.
4. The device according to claim 1 wherein the pressure
differential causing means comprises means for decreasing the
barometric pressure external to the housing.
5. The device according to claim 1 wherein the pressure
differential causing means comprises means for lowering the
temperature within the housing, to, in turn, decrease the pressure
of the gas within the housing.
6. The device according to claim 1 wherein the pressure
differential causing means comprises means for pressurizing the
interior of the housing.
7. The device according to claim 6 wherein the pressure
differential causing means comprises means for facilitating one-way
passage of gas into the housing and precluding passage of gas from
within the housing.
8. The device according to claim 6 wherein the pressurizing means
comprises a gas generating cell.
9. The device according to claim 8 wherein the gas generating means
comprises an electrochemical gas generating cell.
10. The device according to claim 8 further including means for
selectively activating the gas generating cell.
11. The device according to claim 6 wherein the pressurizing means
comprises a piezoelectric cell.
12. The device according to claim 1 wherein the pressure
differential causing means comprises means for altering the volume
of the housing by way of external pressure.
13. The device according to claim 12 wherein the external pressure
results in a change of at least one of temperature or barometric
pressure within the housing.
14. The device according to claim 1 wherein the pressure
differential causing means further includes means for cyclically
varying the pressure differential between the interior of the
housing and the immediate surroundings of the housing.
15. The device according to claim 1 wherein the pressure
differential causing means further includes a check valve, to, in
turn, prevent inadvertent flow of fluid wherein the pressure
differential exceeds a predetermined value
16. The device according to claim 1 wherein the flow control means
further comprises a porous plug.
17. The device according to claim 1 wherein the flow control means
further comprises a tunnel of predetermined length and
cross-sectional area, so as to permit a certain level of maximum
flow therethrough.
18. The device according to claim 17 wherein the tunnel comprises a
helical passage.
19. The device according to claim 17 wherein the tunnel comprises a
sinusoidal path.
20. The device according to claim 17 wherein the opening includes:
a restrictor plug having an outer surface; a receptacle having an
inner surface; and a groove disposed on one of the inner and outer
surfaces, wherein a tunnel is defined by the cooperation of the
groove and the outer surface upon positioning of the restrictor
plug and the receptacle into operative engagement.
21. The device according to claim 20 wherein the groove is disposed
on the outer surface of the restrictor plug.
22. The device according to claim 20 wherein the groove extends
circumferentially about the outer surface of the restrictor
plug.
23. The device according to claim 20 wherein the groove extends
longitudinally along the outer surface of the restrictor plug in
one of a linear and a sinusoidal configuration.
24. The device according to claim 20 wherein the groove comprises a
first groove and a second groove, the first groove is disposed on
the inner surface of the receptacle, the second groove is disposed
on the outer surface of the restrictor plug, the first and second
groove being placed in fluid communication upon positioning of the
receptacle and the restrictor plug into operative engagement.
25. The device according to claim 24 wherein one of an effective
length and an effective area of the tunnel can be varied by
relative movement of the restrictor plug and the receptacle.
26. The device according to claim 1 further comprising an emanator
associated with the opening of the housing.
27. The device according to claim 26 wherein the emanator is
positioned at a predetermined distance from the opening of the
housing.
28. The device according to claim 26 wherein the emanator comprises
a porous material.
29. The device according to claim 26 wherein the emanator comprises
a substantially non-porous material.
30. The device according to claim 26 wherein the emanator further
includes means for enhancing the volatilization of the fluid.
31. The device according to claim 26 wherein the volatilization
enhancing means further comprises a ventilation fan associated with
the emanator.
32. The device according to claim 26 wherein the volatilization
enhancing means further comprises a heating element associated with
at least one of the emanator or the housing.
33. The device according to claim 1 further including means for
providing a bolus, to, in turn, temporarily increase the quantity
of fluid delivered from the device.
34. The device according to claim 33 wherein the bolus providing
means comprises means for increasing the pressure within the
housing, to, in turn, increase flow through the opening.
35. The device according to claim 33 wherein the bolus providing
means further comprises: a second opening associated with the
housing; and means for delivering the fluid within the housing
through the opening.
36. The device according to claim 35 wherein the delivering means
comprises a spray pump.
37. The device according to claim 35 wherein the delivering means
comprises an atomizer.
38. The device according to claim 33 wherein the bolus providing
means further includes means for enhancing the volatilization of
the fluid.
39. The device according to claim 38 wherein the volatilization
enhancing means comprises a heating element.
40. The device according to claim 33 wherein the volatilization
enhancing means comprises a ventilation fan.
41. The device according to claim 1 further including means for
attaching the device to a living being.
42. The device according to claim 41 wherein the attaching means
facilitates attachment of the device to an animal.
43. The device according to claim 1 wherein the device is utilized
within the cabin of an airplane, and the means for causing a
pressure differential causes a pressure differential upon one of
pressurization and depressurization of the cabin of the
airplane
44. The device according to claim 1 wherein the housing includes
means for releasing a predetermined quantity of fluid
therefrom.
45. The device according to claim 44 wherein the predetermined
release means includes: a fixed volume gas chamber; a fixed volume
fluid chamber having a fluid release opening; and separating means
between the fixed volume fluid chamber and the fixed volume gas
chamber.
46. The device according to claim 45 wherein the separating means
comprises a flexible diaphragm.
47. The device according to claim 45 further including a first
fluid control valve operatively associated with the fluid release
opening.
48. The device according to claim 45 further including a fluid
reservoir operatively connected with the fixed volume fluid
chamber.
49. The device according to claim 45 wherein the fixed volume fluid
chamber further includes a second fluid control valve operatively
associated with the fluid reservoir.
50. The device according to claim 1 wherein the housing includes an
interior region defining a fixed volume and where the housing
includes means for selectively altering the volume.
51. The device according to claim 50 wherein the volume selection
means comprises a slidably adjustable sealing member.
52. A method of delivering a fluid comprising the steps of:
providing a fluid within a housing; providing an opening in fluid
communication with the surroundings of the housing and with the
fluid; causing a pressure differential between the housing and the
surroundings of the housing; and utilizing the pressure
differential to direct fluid through the opening.
53. A restrictive opening for controlling the passage of fluid
therethrough comprising: a restrictor plug having an outer surface,
a first end and a second end; a receptacle having an inner surface,
a first end and a second end; and a groove disposed on one of the
inner and outer surfaces extending from the first end to the second
end thereof, wherein a tunnel is defined by the cooperation of the
groove and the outer surface upon positioning of the restrictor
plug and the receptacle into operative engagement to, in turn,
permit the passage of fluid from the first end to the second end of
the restrictor plug in a controlled manner.
54. The device according to claim 53 wherein the groove is disposed
on the outer surface of the restrictor plug.
55. The device according to claim 53 wherein the groove extends
circumferentially about the outer surface of the restrictor
plug.
56. The device according to claim 53 wherein the groove extends
longitudinally along the outer surface of the restrictor plug in a
sinusoidal configuration.
57. The device according to claim 53 wherein the groove comprises a
first groove and a second groove, the first groove is disposed on
the inner surface of the receptacle, the second groove is disposed
on the outer surface of the restrictor plug, the tunnel being
defined by the placement of the first and second groove in fluid
communication upon positioning of the receptacle and the restrictor
plug into operative engagement.
58. The device according to claim 57 wherein one of an effective
length and an effective area of the tunnel can be varied by
relative movement of the restrictor plug and the receptacle, and,
in turn, the first and second grooves.
59. A device for delivering a fluid comprising: a housing having an
interior and an opening; a quantity of fluid within the interior of
housing; means associated with the opening for controlling the flow
of fluid through the opening at a substantially constant rate.
60. The device of claim 59 wherein the flow controlling means
controls the flow at the substantially constant rate substantially
independent of the quantity of fluid within the interior of the
housing.
61. A device for delivering a fluid comprising: a housing having an
interior and an opening; a quantity of fluid within the interior of
housing, the fluid having an effective dose; means for forcing a
predetermined quantity of fluid from within the interior of the
housing to the opening; and means associated with the opening for
controlling the flow of fluid through the opening, at a flow rate
substantially corresponding to the effective dose of the fluid.
64. A device for delivering a fluid comprising: a housing having an
interior and an opening; a quantity of fluid within the interior of
housing, the fluid comprising a parasiticide in an effective dose;
means for forcing a predetermined quantity of fluid from within the
interior of the housing to the opening; and means associated with
the opening for precluding the development of resistance to the
parasiticide.
65. A method of delivering a fluid comprising the steps of:
providing a fluid within a housing; providing an opening in fluid
communication with the surroundings of the housing and with the
fluid; and directing fluid through the opening at a substantially
constant rate.
66. A method of delivering a fluid comprising the steps of:
providing a fluid within a housing the fluid having an effective
dose; providing an opening in fluid communication with the
surroundings of the housing and with the fluid; and directing fluid
through the opening at a rate substantially corresponding to the
effective dose.
67. The method of claim 66 further comprising the step of
continuing the step of directing the fluid until substantially all
of the fluid has been directed from within the housing.
Description
BACKGROUND OF THE INVENTION
[0001] 1. Field of the Invention
[0002] The present invention relates in general to the release of
fluids and, more particularly, to a device for controllably
releasing fluids to the surrounding environment.
[0003] 2. Background Art
[0004] Devices for delivering fluid from a container to the
environment, have been known in the art for several years. In
particular, many of these devices make use of the principle of
diffusion. For instance, some devices make use of a wick based
system. In these systems, one end of a wick is placed in a fluid to
be dispensed, while the other end is exposed to the atmosphere.
Capillary action forces liquid through the wick and up to the
exposed end, where the liquid evaporates off of the end of the wick
and into the surrounding atmosphere or is wiped off by mechanical
means.
[0005] Other devices make use of a gravity driven mechanism,
allowing liquids to diffuse through a membrane under the force of
gravity. Under the force of gravity, the liquid diffuses through
the membrane and volatilizes into the surrounding atmosphere from
the exposed surface of the membrane.
[0006] Although these and other conventional controlled delivery
systems have worked well, they have failed to provide for both the
controlled and constant (i.e. substantially linear) release of
fluids over an extended period of time and the ability to utilize
the delivery systems in rugged or more extreme situations.
Moreover, it has been difficult to utilize non-volatile liquids,
liquids of higher viscosity and gels.
SUMMARY OF THE INVENTION
[0007] The present invention is directed to a device for delivering
a fluid. The device comprises a housing having an interior, an
opening, a gas head space and quantity of fluid within the housing.
The device also includes means for causing a pressure difference
between the interior of the housing and the immediate surroundings
of the housing, wherein the pressure difference forces a
predetermined quantity of fluid from within the housing to the
opening. Additionally, means are associated with the opening for
controlling the flow of fluid therethrough.
[0008] In a preferred embodiment of the invention, the pressure
differential causing means comprises means for increasing the
temperature within the housing which, in turn, increases the
pressure of the gas within the housing. The pressure differential
causing means may likewise comprise means for lowering the
temperature within the housing, to, in turn, decrease the pressure
of the gas within the housing.
[0009] In another preferred embodiment, the pressure differential
causing means may comprise means for increasing or decreasing the
barometric pressure external to the housing.
[0010] In another preferred embodiment of the invention, the
pressure differential means comprises means for pressuring the
interior of the housing. The pressurizing means may comprise a gas
generating cell, which can be activated by various means.
[0011] In yet another preferred embodiment of the invention, the
pressure differential causing means may further include means for
cyclically varying the pressure differential between the interior
of the housing and the immediate surroundings of the housing.
[0012] In still another preferred embodiment, the pressure
differential causing means may include a check valve, to, in turn,
prevent inadvertent flow of fluid when the pressure differential
exceeds a predetermined value. It is also contemplated that the
flow control means comprise a porous plug.
[0013] In another preferred embodiment, the flow control means may
include a tunnel of predetermined length and cross-sectional area,
so as to permit a certain level of maximum flow therethrough. In
one such embodiment, the tunnel may comprise a tortuous path such
as a helical configuration, although other configurations, such as
sinusoidal paths are likewise contemplated.
[0014] In one preferred embodiment of the invention, the device
further comprises an emanator associated with the opening of the
housing. The emanator may be positioned a predetermined distance
from the opening of the housing and can be constructed of a
porous-type material. It is also contemplated that the emanator
includes a non-porous surface.
[0015] In such a preferred embodiment, the emanator may include
means for enhancing the volatilization of fluid which is volatile.
Such enhancing means may comprise a ventilation fan associated with
the emanator, a heating element or ultrasonic energy, among other
things.
[0016] In another preferred embodiment, the invention further
includes means for providing a bolus to, in turn, temporarily
increase the quantity of fluid delivered from the device. The bolus
providing means may comprise means for increasing the pressure
within the housing so as to increase the flow of fluid through the
opening. The bolus may include a second opening associated with the
housing, as well as means for delivering the fluid within the
housing through the opening.
[0017] In such a preferred embodiment, it is contemplated that the
delivering means comprises a spray pump or an atomizer.
[0018] In still another preferred embodiment of the invention, the
device includes means for attachment to a living being, such as to
the ear of an animal, or to the wall or window of a vessel, among
other attachment environments.
[0019] In another preferred embodiment of the invention, the
housing includes means for releasing a predetermined quantity of
fluid therefrom. In such an embodiment, the predetermined release
means includes a fixed volume gas chamber, a fixed volume fluid
chamber having a fluid release opening, and separating means
between the fixed volume fluid chamber and the fixed volume gas
chamber. The separating means may comprise a flexible diaphragm
which, upon increased expansion of the gas in the fixed volume gas
chamber, is forced against the fluid.
[0020] In such a preferred embodiment, the housing may include a
first fluid control valve (check valve) operatively associated with
the fluid release opening. The device may further include a fluid
reservoir which is operatively connected with the fixed volume
fluid chamber. The fixed volume fluid chamber may include a second
fluid control valve (check valve) operatively associated with the
fluid reservoir.
[0021] The present invention is also directed to a method of
delivering a fluid comprising the steps of a) providing a fluid
within a housing; b) providing an opening in fluid communication
with the surroundings of the housing and with the fluid; c) causing
a pressure difference between the housing and the surroundings of
the housing; and d) utilizing the pressure difference to direct
fluid through the opening.
[0022] The invention further comprises a restrictive opening for
controlling the passage of fluid therethrough. The restrictive
opening comprises a restrictor plug, a receptacle and a groove. The
restrictor plug includes an outer surface, a first end and a second
end. The receptacle includes an inner surface, a first end and a
second end. The groove is disposed on one of the inner and outer
surfaces extending from the first end to the second end thereof. A
tunnel is defined by the cooperation of the groove and the outer
surface as a result of the positioning of the restrictor plug and
the receptacle into operative engagement. The tunnel permits the
passage of fluid from the first end to the second end of the
restrictor plug in a controlled manner.
[0023] In a preferred embodiment, the groove is disposed on the
outer surface of the restrictor plug. In another preferred
embodiment, the groove extends circumferentially about the outer
surface of the restrictor plug. In yet another preferred
embodiment, the groove extends longitudinally along the outer
surface of the restrictor plug in a sinusoidal configuration.
[0024] Preferably, the groove comprises a first groove and a second
groove. The first groove is disposed on the outer surface of the
restrictor plug. The second groove is disposed on the inner surface
of the receptacle. The tunnel is defined by the placement of the
first and second groove in fluid communication upon positioning of
the receptacle and the restrictor plug into operative
engagement.
[0025] In such a preferred embodiment, one of an effective length
and an effective area of the tunnel can be varied by relative
movement of the restrictor plug and the receptacle, and, in turn,
the first and second groove.
[0026] In another aspect of the invention, the invention comprises
a device for delivering fluid. The device includes a housing having
an interior region and an opening. A quantity of fluid is disposed
within the interior of the housing. Means are associated with the
opening for controlling the flow of fluid through the opening at a
substantially constant rate.
[0027] In another aspect of the invention, the invention comprises
a housing having a quantity of fluid within its interior. The fluid
includes an effective dose. Means are associated with an opening of
the housing for controlling the flow of fluid to a rate
substantially corresponding to the effective dose of the fluid.
[0028] In another aspect of the invention, the invention comprises
a device for delivering a fluid. In such an embodiment, means are
associated with the opening for precluding the development of
resistance to the parasiticide.
BRIEF DESCRIPTION OF THE DRAWINGS
[0029] FIG. 1 is a side elevational view of a first embodiment
having controlled substance release device means;
[0030] FIG. 2 is a cross-sectional view of the first embodiment
taken about lines 2-2 of FIG. 1;
[0031] FIG. 3 is a partial cross-sectional view of the first
embodiment taken about lines 3-3 of FIG. 1;
[0032] FIG. 4 is a side elevational view of a second embodiment of
the controlled substance release device;
[0033] FIG. 5 is a side elevational view of a third embodiment of
the controlled substance release device;
[0034] FIG. 6 is a side elevational view of a fourth embodiment of
the controlled substance release device;
[0035] FIG. 7(a) is a performance graph of experimental test data
for quantity of fluid dispensed through tunnels of various pitch
over a period of time;
[0036] FIG. 7(b) is a graph of oven temperature cycle used to
generate the data in the graph of FIG. 7a;
[0037] FIG. 7(c) is a theoretical performance calculation of a
device in two different temperature cycle profiles;
[0038] FIG. 7(d) is a graph of the two temperature cycle profiles
used to calculate the results of FIG. 7(c);
[0039] FIG. 7(e) is a graph of test results showing the efficacy of
two sample devices prepared in accordance with the present
invention over a period of 70 days;
[0040] FIG. 8 is a schematic representation of a preferred
embodiment of the controlled substance release device;
[0041] FIG. 9 is a perspective view of another embodiment of the
restrictor plug;
[0042] FIG. 10 is a front elevational view of the embodiment of the
restrictor plug shown in FIG. 9; and;
[0043] FIG. 11 is a front exploded view of another embodiment of
the opening.
DETAILED DESCRIPTION OF THE DRAWINGS
[0044] While this invention is susceptible of embodiment in many
different forms, there is shown in the drawings and will herein be
described in detail, several specific embodiments with the
understanding that the present disclosure is to be considered as an
exemplification of the principles of the invention and is not
intended to limit the invention to the embodiments so
illustrated.
[0045] Control substance release device 10 is shown in FIGS. 1 and
2 as comprising housing 12, fluid 14 and means 16 for causing a
pressure differential and possibly means for enhancing delivery. As
will be explained in detail, device 10 can be utilized in various
environments, such as in association with the release of a fluid
(i.e parasiticide which is a chemical or biological agent or other
means for controlling, killing or reducing the population of any
life cycle stage of insects, acarines and other parasites that
infest or infect vertebrate animals and their surroundings) to the
skin of a living being, such as a human or an animal, as well as in
association with release of a fluid (i.e. fragrance) in the cabin
of an airplane, an airplane lavatory or elsewhere in an airplane
body. Indeed, these are examples only and the invention is not
limited to any particular environment, field of use fluid.
[0046] Housing 12 is shown in FIG. 2 as including interior region
20 which retains the desired fluid, opening 22 which is in fluid
communication with the surroundings outside of the housing and
means 24 for attaching the housing to another object. Housing 12
generally comprises a natural or synthetic plastic material,
however, other materials, such as glass, metals and alloys thereof
are likewise contemplated for use. Certain materials may be
selected based on their heat retention, absorption and dissipation
characteristics. Generally, it is preferred that the housing be
substantially rigid so that the variations in the pressure do not
expand or contract the housing, and, in turn, the interior region.
However, as will be explained below, in certain embodiments, it is
advantageous to alter the volume of interior region 20.
[0047] It is contemplated that interior region 20 includes a volume
of about 10-15 cm.sup.3. However, it will be understood that the
interior region is not limited to any particular size nor to a
particular range of sizes. As will be explained below, the interior
region is utilized for the storage of both air and another fluid.
The fluid contemplated for use in association with the present
invention may comprise, for example, any one of perfumes,
parasiticides, insect repellants, air fragrances, medicines,
greases and pastes and combinations thereof, in liquid and/or gel
form and in varying viscosities. In certain embodiments, the
housing may be provided prefilled with a fluid for a single use. In
other embodiments, the housing may include a refilling port which
will enable a user to refill and reuse the device.
[0048] Regardless of the type of fluid utilized, the interior
region likewise includes an initial quantity of air (or other gas).
As will be explained, the pressure differential causing means acts
upon this quantity of air to, in turn, drive fluid from within the
interior region, or to facilitate the entry of gas from ambient.
The initial quantity of air that is supplied in the interior region
can be varied to achieve various initial delivery rates until the
linear dispensing is reached. Specifically, the greater the initial
volume of air, the quicker the device reaches the desired delivery
rate.
[0049] Opening 22 is shown in FIGS. 2 and 3 as comprising
receptacle 71, restrictor plug 73, retaining member 93, and means
34 for controlling the flow of fluid. Receptacle 71 includes inner
surface 75, first end 82 and second end 84. In one embodiment,
opening 22 and housing 12 comprise a material which facilitates
assembly by way of ultrasonic welding of the opening to the lower
end of housing 12. Restrictor plug 73 includes first end 86, second
end 88 and groove 77 in outer surface 79. As such, when restrictor
plug is positioned within receptacle 71, and inner surface 75 is in
abutment with outer surface 79, tunnel 81 is defined by groove 77
in cooperation with inner surface 75 and outer surface 79. In turn,
the groove essentially provides the means for controlling the fluid
flow through the opening. As will be understood, retaining member
93 comprises a snap ring which cooperates with a corresponding
recess positioned on inner surface 75 of receptacle 71, to, in
turn, retain the restrictor plug within the receptacle.
[0050] In the embodiment shown, tunnel 81 includes tortuous path 36
(i.e. a path which restricts the free flow of fluid), such as
helical passage 38 which extends around outer surface 79 of
restrictor plug 73 and includes a cross-sectional area, a volume, a
length and a pitch. The tunnel restricts the rate at which the
fluid can be released from interior region 20 (i.e. a maximum flow
rate). As will be understood, by varying any one or more of the
length, cross-sectional area, a volume and/or pitch, different
rates of release of the fluid can be achieved. (See the graphs of
FIGS. 7a and 7b). In addition, while a single tunnel is shown,
there is no limit on the quantity of tunnels that may be utilized.
In another embodiment, the tortuous path may comprise a tunnel
having a non undulating, straight path. Such an embodiment may be
well suited for fluids having relatively higher viscosities.
[0051] The tunnel is not limited to any particular configuration or
to extending about the circumference of the outer surface. For
example, as shown in FIGS. 9 and 10, groove 77 may comprise two
sinusoidal (or other shaped) paths that generally do not extend
about the entire circumference of the outer surface of the
restrictor plug. In such an embodiment, the length of the tunnel
can be varied by varying the amplitude or the frequency of the
sinusoid.
[0052] In another embodiment, as shown in FIG. 11 it is likewise
contemplated that first groove 83 may be disposed on the outer
surface of the restrictor plug and second groove 85 may be disposed
on the inner surface of the receptacle. In such an embodiment, the
first and second grooves are positioned so that they are in fluid
communication with each other and so that they cooperate to provide
a passage for the fluid. By rotating or longitudinally moving the
outer surface of the restrictor plug and the inner surface of the
receptacle, the orientation of each groove can be changed relative
to the other groove to, in turn, adjust and vary the effective
length and cross-sectional area of the resulting tunnel.
[0053] Advantageously, since the path of tunnel 81 is relatively
lengthy and relatively small in cross-sectional areas, it is
difficult to displace the fluid therein at a rate exceeding the
pressure of the interior region. Thus, even if the device is shaken
or otherwise moved or jarred, the flow of fluid within tunnel 81 is
largely unaffected.
[0054] Opening 22 may additionally include filter 40 to preclude
the passage of undesired debris and contaminants into interior
region 20.
[0055] In other embodiments, opening 22 may include a membrane (not
shown) positioned over the opening to control the permeation of the
fluid from interior region 20 of device 10. Such a membrane helps
control the pressure within interior region 20 of housing 12, and,
in turn, permeation of the fluid, by maintaining a certain vacuum
due to the action of gravity thereagainst. Alternatively, and as
shown in FIG. 2, the membrane 65 (shown in dashed lines) may be
located at the top, controlling the permeation of air out of the
headspace.
[0056] Attachment means 24, as shown in FIGS. 1 and 2, may comprise
a variety of structures for facilitating attachment to an outside
surface (i.e. a living being such as an animal). In the embodiment
shown, attachment means 24 is integrally formed with housing 12 and
includes opening 46 (i.e. the female component) which facilitates
the receipt of a fastener (i.e. the male component, such as a
rivet), or the like. In an alternate configuration, the male
component may be integrally formed with the housing, in which case
the female component is fastened thereto. In other embodiments, the
attachment means may comprise other structures such as a cord, an
adhesive double-stick tape, a hook-loop fastener among others.
[0057] As shown in FIG. 4, control substance release device 10 may
additionally include volatilization enhancing means 18. The
volatilization enhancing means can be associated with opening 22 to
further enhance volatilization of the fluid, wherein the fluid
comprises a volatile substance. For example, the volatilization
enhancing means may comprise emanator pad 26 (comprising a porous
material, such as a sponge, paper element and fabric or a
non-porous material) which can be positioned to receive the
volatile substance as it exits opening 22. Additionally, fans 30,
heating element 28 and/or ultrasonic energy, among others, can be
associated with emanator pad 26 as a means of enhancing the
volatilization of such a fluid. The emanator pad can be positioned
at any predetermined distance from the opening.
[0058] Volatilization enhancing means 18 may further include means
32 for providing a bolus, to, in turn, temporarily increase the
delivery of the volatile fluid from the device. The bolus providing
means may comprise a second opening 42 and means 44 for delivering
fluid to the second opening. Delivering means 44 may comprise an
atomizer or a spray pump which can be activated manually, or,
alternatively, can be activated automatically and cyclically upon
exposure to a predetermined pressure build up. As an example, such
a bolus providing means is particularly applicable for use in
association with a device attachable to an animal having
parasiticide therein. It is also contemplated that the bolus be
used in an embodiment that does not use a volatile fluid. Likewise,
the bolus may be used in association with the above-described fans,
heating elements and ultrasonic energy.
[0059] Pressure differential causing means 16 is shown in FIG. 5 as
comprising a variety of means which cause a pressure differential
between interior region 20 and the ambient conditions (temperature
and barometric pressure) of the immediate surroundings of housing
12. As will be explained, such a pressure difference between these
zones forces a predetermined quantity of fluid from within the
housing through the opening, and replaces the lost fluid with air
from the surroundings.
[0060] In one embodiment, the pressure differential causing means
may comprise a means for increasing the temperature of interior
region 20 of housing 12. (See FIGS. 7c and 7d). Such an embodiment
is well suited for use, for example, in association with an animal
parasiticide dispenser which may be attached to an animal, such as
an ear of a cow. Specifically, as the animal grazes in the open
field, housing 12 absorbs heat radiated by the sun, thereby causing
an increase in temperature of the interior region 20 as well as the
fluid and any other gaseous material therein (air and any vaporized
fluid). With respect to the fluid and the gaseous material, an
increase in temperature likewise increases the pressure within the
interior region of the housing. In turn, the pressure within the
housing becomes greater than the barometric pressure of surrounding
ambient conditions. The pressure difference forces the fluid toward
opening 22 in housing 12. Next, fluid is driven by the internal
pressure through tunnel 81 defined by groove 77 to ambient. It is
likewise contemplated that in certain embodiments the user may be
able to adjust (i.e. decrease or increase) the volume of the
interior region so as to increase or decrease the pressure
therewithin. For example, housing 12 may include a manually
adjustable piston-like configuration 92 (FIG. 1) which enables
operative adjustment/altering of the interior volume of the
housing.
[0061] At the end of the day, or at any time that ambient
temperature reduces, the device cools. In turn, the internal gas
(i.e. vaporized fluid and air) cools, the pressure is reduced and
the gas within the interior region essentially contracts. To
compensate for the contraction of the gas remaining in interior
region 20, outside air (or other gas) is directed into tunnel 81
defined by groove 77, and in turn, into interior region 20. The
next day, or when the ambient temperature again increases the cycle
is repeated. The cycle can continue until such time that the fluid
is substantially dispensed.
[0062] By utilizing a restricted opening (i.e one with tunnel 81)
in cooperation with the pressure differential causing means, the
rate of delivery of fluid through opening 22, in either direction,
can be closely controlled. In fact, a slow rate of flow in either
direction via opening 22 can be achieved, and such a rate can be
maintained for an extended period of time (i.e. 120 days or more).
More specifically, without any restriction on the opening, the flow
through opening 22 is governed by the Ideal Gas Law, i.e. gas
volume, pressure and temperature differences only. However, by
adding a restricted opening, an additional variable is presented,
namely, a maximum flow rate that can be achieved through tunnel 81.
By sizing the restricted opening (i.e., the cross-sectional area,
pitch, volume and/or the length of the tunnel), varying maximum
delivery rates can be achieved. In turn, once the pressure
difference causes a maximum flow condition through the opening,
further pressure differences may extend the duration of the flow
(i.e. a substantially constant flow rate providing a substantially
linear dispensing), but will not further increase the flow rate
significantly. Thus, a more uniform distribution of flow over a
longer time period can be achieved. In addition, since the flow
rates will not increase substantially, customization of device 10
for specific geographic regions may not be necessary.
[0063] Use of the restricted opening in cooperation with the
pressure differential causing means of the present invention is
particularly suitable for use in association with an animal ear tag
to deliver a parasiticide. Conventional ear tags which generally
comprise a molded polymer matrix impregnated with a substance such
as a parasiticide have an inconsistent, erratic and incomplete
delivery of the substance. Among other delivery problems, these
tags release the substance after packaging, wherein the substance
crystallizes on the surface of the tag itself, exposing the user to
a high concentration of the parasiticde. Further, these tags
initially supply excessive doses of the substance and over time
reduce the level of delivery until the supply of the substance
falls below an effective dose. Exposure to non effective doses
causes parasites to develop resistance to the substance. Moreover,
such tags are generally limited to certain substances due to
solubility and/or compatibility concerns between the substance and
the polymer matrix as well as due to molecular weight and size
constraints. For example, compounds like ivermectin and spinosad
have relatively high molecular weights (>700) and poor
solubility in various polymers such as polyethylene which
essentially render these compounds unable to be formulated in
conventional ear tags.
[0064] To the contrary, the present invention provides for a
substantially constant delivery rate resulting in a substantially
linear delivery of fluid which can be adjusted by altering the
above-described properties of tunnel 81. As a result, a proper dose
of the fluid can be maintained throughout the life of the device,
and until substantially all of the fluid is depleted. In turn, such
control of the delivery of fluid essentially provides a means for
precluding the development of resistance by parasites by providing
consistent, therapeutic levels of the parasiticides.
[0065] In addition, since the primary delivery is not through
diffusion and is not dependent on high solubility of a parasiticide
in a polymer matrix, the fluid utilized in the present invention
can be expanded to include previously unusable parasiticides and
still include compounds previously dissolved in polymer matrices.
These include, but are not limited to various avermectins,
benzimidazoles, milbemycins, carbamates, organophosphates,
phenylpyrazoles, amidines, insect growth regulators, juvenile
hormones, nicotinoids, pyrroles and naturalytes (i.e. the spinosyn
family). Representative compounds may include abamectin,
doramectin, eprinomectin, selamectin, alphamethrin, amitraz,
coumaphos, ivermectin, deltamethrin, cyhalothrin, diazinon,
cyromazine, cypermethrin, milbemycin, cyfluthrin, cyloprothrin,
famphur, fenthion, fenvalerate, flucythrinate, flumethrin,
hexaflumuron, lindane, lufenuron, malathion, methoprene,
metriphonate, moxidectin, permethrin, pyrethrin, pyrethrum,
phosmet, pirimiphos, chlorvinphos, rotenone, propetamphos,
tetrachlorvinphos, zetacypermethrin and spinosad, among others.
[0066] Two samples prepared in accordance with the teachings of the
present invention were tested. The embodiments which included a
spinosad compound (which is generally not usable in association
with conventional devices) in a fluid formulation were tested in
extreme conditions. The composition of the spinosad compound was as
follows: Spinosad @90%, 16.7% wt/wt; Isopropyl myristate, 23.2%
wt/wt; Oleic acid, 60.0% wt/wt; Antioxidant 0.1% wt/wt. The test
comprised the comparison of the quantity of flies contained on
three different groups of animals. The first group did not have any
parasiticide control device or parasiticide applied thereto. The
second and third groups utilized one of the two sample devices
prepared in accordance with the present invention. The differences
between the embodiments utilized on the second and third groups
comprised changes in the properties of the tunnel.
[0067] Results were obtained over time wherein efficacy of each of
the sample devices was calculated by comparing the quantity of
flies on the first group of animals to the quantity of flies on
each of the second and third groups. From this, an efficacy ratio
was calculated for each of the second and third groups of animals.
A graph depicting the results of the test over the first 70 days is
shown in FIG. 7(d) wherein "Group 4" represents the second group of
animals and "Group 5" represents the third group. As can be seen,
each embodiment of the invention maintained an efficacy in excess
of 75% (and often in excess of 90%) in these extreme conditions
over the first 70 days.
[0068] In another embodiment of the invention, the pressure
differential causing means may comprise means for decreasing the
pressure of the immediate surroundings of the device. Such an
embodiment is well suited, for example, in association with a cabin
of an airplane, or an airplane lavatory. In particular, as the
plane takes off, the cabin pressure decreases an amount which, in
turn, creates a pressure difference between interior region 20 of
housing 12 and the surrounding ambient air. In turn, the greater
pressure within interior region 20 forces the fluid from within the
interior region through opening 22 (which may or may not include a
restrictor). As the plane lands, the pressure becomes greater in
the cabin. As a result, cabin pressure after landing is greater
than the pressure within interior region 22, and, in turn, air is
directed from ambient surroundings through opening 22 into interior
region 22. This cycle is repeated each time the cabin is
depressurized until the substance is fully dispensed.
[0069] In one such an embodiment, as shown in FIG. 5, the pressure
differential causing means may further include gas generating cell
48 (such as a conventional electrochemical gas generating cell,
piezoelectric cell or other non-electrochemical gas generating
cell). Such a cell generates a gas (pressure) within interior
region 20 of housing 12. These cells are useful to generate
pressure within interior region 20 to maintain the flow of fluid
from the interior region, in, for example, longer flights.
[0070] In the embodiment of FIG. 5, the gas generating cell may
include means 50 for selectively activating the cell. Wherein the
cell comprises an electrochemical gas generating cell, the
selective activating means may comprise a manual switch or an
automatic switch which is activated upon the sensing of a
predetermined condition. A predetermined condition may comprise a
predetermined temperature, pressure or the passage of a
predetermined period of time, for example.
[0071] In another embodiment, shown in FIG. 6, wherein the volume
of the interior region of the housing is capable of being altered,
the pressure differential causing means comprises means for
increasing the pressure of the immediate surroundings of the
device. In such an embodiment, housing 12 may be substantially
flexible and capable of being compressed by ambient pressure.
Alternatively, the interior region may include a plunger or piston
slidably movable therein (such as shown in FIG. 1).
[0072] In such an embodiment, as the pressure increasing means
increases the pressure immediately surrounding the housing, the
flexible housing will react to the pressure by reducing the volume
(i.e., collapsing) of the interior region thereof. The collapse of
the interior region of the housing will, in turn, force the fluid
within the interior region of housing toward the opening therein.
Such an embodiment is well suited for use in association with the
cabin or interior quarters of, for example, a submarine wherein an
increase in pressure of the cabin (interior quarters) of the
submarine creates a pressure differential between ambient and the
pressure within the interior region of the housing. The pressure
differential, as explained above, causes compression of the housing
and causes the fluidic substance within interior region 20 of
housing 12 to be dispensed through the opening in the housing
(which may or may not include flow control means 34). This will
continue until the pressure within the housing and the pressure
surrounding the housing is equalized.
[0073] As the submarine returns to the surface, the pressure in the
cabin is reduced, thereby returning the housing to its original
configuration. In turn, the volume of the interior region returns
to the original volume. During this expansion of the interior
region, air from the cabin is directed through opening 22 to
interior region 20 until the pressure within the interior region
reaches equilibrium with ambient. The next time that the submarine
dives, the cycle will begin to repeat. This cycle will continue
until the fluid is depleted.
[0074] Embodiments, other than those specifically described for
illustrative purposes only, are envisioned which include means that
cause a pressure difference between the interior region of the
housing and the area surrounding the housing. Inasmuch as the
difference in pressure between the interior region of housing and
the region surrounding the housing is related to the temperature
and to the volume of the interior region, changes to the volume,
pressure or temperature of either of the interior region of the
housing or the region surrounding the housing can cause a pressure
difference therebetween.
[0075] For example, another preferred embodiment of control
substance release device 110 is shown in FIG. 8 as comprising
housing 112, fluid 114 and means 116 for causing a pressure
differential between ambient and the interior of the housing. In
particular, housing 112 includes hermetically sealed fixed volume
gas chamber 120, fixed volume fluid chamber 122, fluid control
valve 124 (check valve) and flexible diaphragm 126 operatively
separating the fluid chamber and the gas chamber. These elements
generally provide a means for releasing a predetermined quantity of
fluid therefrom. In addition, and as will be explained, fluid
reservoir 130 is operatively associated with fixed volume fluid
chamber 122. As can be seen, another fluid control valve 124' is
positioned where the fluid reservoir feeds into the fixed volume
fluid chamber. In another embodiment, flexible diaphragm may
comprise a slidably adjustable sealing member which provides a
means to selectively alter the volume of the housing.
[0076] In operation, fluid, originally retained in fluid reservoir
130, passes through fluid control valve 124' and enters into fixed
volume fluid chamber 122. When the fluid chamber's volume is
substantially occupied by fluid, no more fluid will be allowed to
enter the chamber. Inasmuch as fluid reservoir 130 will be vented
to atmosphere, flow of fluid will be relatively unrestricted.
[0077] As ambient temperature increases or ambient barometric
pressure decreases, relative to the gas occupying fixed volume gas
chamber 120, the gas in the chamber begins to expand. As the gas
continues to expand, it exerts a pushing force on flexible
diaphragm 126, which, in turn, exerts a pressure on the fluid
within fixed volume fluid chamber 122. As the fluid starts to
displace, fluid control valve 124' closes (as a result of the force
exerted thereon by the fluid in the fixed volume fluid chamber) and
fluid control valve 124, located at the bottom of fixed volume
fluid chamber 122 becomes forced open. As a result, the fluid
occupying the fixed volume fluid chamber is operatively released
therefrom. Preferably, housing 112 is configured so that the
minimum temperature and/or pressure change expected in a cycle will
be sufficient to dispense the entire contents of the fluid
occupying the fixed volume fluid chamber.
[0078] As the gas in fixed volume gas chamber 120 contracts, due to
a reversal in the pressure differential (caused by a decrease in
ambient temperature or an increase in ambient barometric pressure),
fluid control valve 124' closes and fluid control valve 124 opens.
As a result, fluid, from fluid reservoir 130, is again allowed to
fill fixed volume fluid chamber 122 wherein the fluid dispensing
cycle can be repeated. Although not shown, it is contemplated that
fluid reservoir 130 includes a removable portion so that it can be
refilled with fluid as desired.
[0079] The foregoing description and drawings merely explain and
illustrate the invention and the invention is not limited thereto
except insofar as the appended claims are so limited, as those
skilled in the art who have the present disclosure before them will
be able to make modifications and variations therein without
departing from the scope of the invention.
* * * * *