U.S. patent application number 09/919067 was filed with the patent office on 2002-09-26 for compositions used in human treatment.
Invention is credited to Cochran, Timothy.
Application Number | 20020136711 09/919067 |
Document ID | / |
Family ID | 21858287 |
Filed Date | 2002-09-26 |
United States Patent
Application |
20020136711 |
Kind Code |
A1 |
Cochran, Timothy |
September 26, 2002 |
Compositions used in human treatment
Abstract
A composition for treatment of a human body comprises a
combination of at least one hormone, at least one amino acid, at
least one enzyme and/or vitamin, and least one mineral. The
relative proportions of the hormone, amino acid, enzyme and mineral
in the combination are balanced with respect to each other so as to
be present in effective amounts to substantially restore to optimal
levels in the body the hormone, amino acid, enzyme and mineral The
hormone, amino acid, enzyme and mineral in the combination further
operate synergistically to provide both nutrients and command
components to enable the body to effectively utilize the nutrients.
The invention is also a method of forming a composition for the
treatment of a human body.
Inventors: |
Cochran, Timothy; (Cedar
Pines Park, CA) |
Correspondence
Address: |
Colin P. Abrahams
Suite 400
5850 Canoga Avenue
Woodland Hills
CA
91367
US
|
Family ID: |
21858287 |
Appl. No.: |
09/919067 |
Filed: |
July 30, 2001 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
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09919067 |
Jul 30, 2001 |
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09512729 |
Feb 24, 2000 |
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09512729 |
Feb 24, 2000 |
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09031227 |
Feb 26, 1998 |
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6048846 |
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Current U.S.
Class: |
424/94.1 ;
514/167; 514/171; 514/419 |
Current CPC
Class: |
A23V 2002/00 20130101;
A23V 2002/00 20130101; A23V 2002/00 20130101; A23V 2002/00
20130101; A23V 2002/00 20130101; A23V 2002/00 20130101; A23L 33/10
20160801; A61K 45/06 20130101; A23V 2250/0606 20130101; A23V
2250/0622 20130101; A23V 2250/06 20130101; A23V 2250/1588 20130101;
A23V 2250/61 20130101; A23V 2250/211 20130101; A23V 2250/188
20130101; A23V 2250/708 20130101; A23V 2250/156 20130101; A23V
2250/187 20130101; A23V 2250/06 20130101; A23V 2250/0612 20130101;
A23V 2250/0644 20130101; A23V 2250/1842 20130101; A23V 2250/0604
20130101; A23V 2250/71 20130101; A23V 2250/1868 20130101; A23V
2250/1882 20130101; A23V 2250/16 20130101; A23V 2250/0652 20130101;
A23V 2250/0616 20130101; A23V 2250/156 20130101; A23V 2250/0628
20130101; A23V 2250/1642 20130101; A23V 2250/0626 20130101; A23V
2250/1578 20130101; A23V 2250/714 20130101; A23V 2250/1886
20130101; A23V 2250/062 20130101; A23V 2250/71 20130101; A23V
2250/712 20130101 |
Class at
Publication: |
424/94.1 ;
514/171; 514/167; 514/419 |
International
Class: |
A61K 038/43; A61K
031/59; A61K 031/57; A61K 031/404 |
Claims
1. A composition for treatment of a human body, the composition
comprising a combination of: a) at least one hormone; b) at least
one amino acid; c) at least one enzyme and/or vitamin; d) at least
one mineral wherein the relative proportions of said hormone, amino
acid, enzyme and mineral in the combination are balanced with
respect to each other so as to be present in effective amounts to
substantially restore to optimal levels in the body said hormone,
amino acid, enzyme and mineral, the hormone, amino acid, enzyme and
mineral in the combination further operating synergistically to
provide both nutrients and command components to enable the body to
effectively utilize said nutrients.
2. A composition as claimed in claim 1 wherein the hormone is
selected from one or more of the group consisting of:
dehydroepiandrosterone (DHEA), melatonin and Vitamin D3.
3. A composition as claimed in claim 1 wherein DHEA is present so
as to provide a dose of 75-200 mg per day.
4. A composition as claimed in claim 2 wherein melatonin is present
so as to provide a dose of 5-12 mg per day.
5. A composition as claimed in claim 1 wherein the enzyme is
coenzyme Q10.
6. A composition as claimed in claim 5 wherein coenzyme Q10 is
present in the composition so as to provide a dose of between 240
mg and 600 mg per day.
7. A composition as claimed in claim 6 wherein coenzyme Q10 is
present in the composition so as to provide a dose of between 360
mg and 540 mg per day.
8. A composition as claimed in claim 1 further comprising an
antioxidant.
9. A composition as claimed in claim 8 wherein the antioxidant is
selected from one or more of the group consisting of:
multi-carotenes, alpha-, beta- and gamma carotenes, lycopene,
lutein zeanthins, Vitamin E, Vitamin C and Niacin.
10. A composition as claimed in claim 9 wherein alpha-carotene is
dosed at 25-40 mg per day, beta-carotene is dosed at 50-60 mg per
day and gamma-carotene is dosed at 1-5 mg per day.
11. A composition as claimed in claim 9 wherein lycopene is dosed
at 1-5 mg per day, lutein is dosed at 1-10 mg per day and zeanthin
is dosed at 200-500 mcg per day.
12. A composition as claimed in claim 9 wherein Vitamin E is dosed
at 800-4000 IU per day.
13. A composition as claimed in claim 12 wherein Vitamin E is dosed
at between 2000 and 3000 IU per day.
14. A composition as claimed in claim 9 wherein Vitamin C is dosed
at between 1500 and 4000 mg per day.
15. A composition as claimed in claim 9 wherein the Niacin contains
inositol hexanicotinate.
16. A composition as claimed in claim 15 wherein Niacin inositol
hexanicotinate is dosed at between 400 and 600 mg per day.
17. A composition as claimed in claim 15 wherein the Niacin
inositol hexanicotinate is dosed at between 800 and 1200 mg per
day.
18. A composition as claimed in claim 1 wherein the composition is
a combination based on the formula:
H.times.A2+E3+M3a+DRR.gtoreq.TR, wherein H is hormone, A is amino
acid, E is enzyme, M is mineral, DRR is DNA and/or RNA command
regulation, and TR is tissue regeneration.
19. A composition as claimed in claim 1 comprising a Vitamin
B-complex, the Vitamin B-complex containing one or more of the
components in the following group: folic acid, Vitamin B1, Vitamin
B2, Vitamin B3 (niacin), Vitamin B3 (niacinamide), Vitamin B5,
Vitamin B6, Vitamin B12, biotin, inositol, choline and
para-aminobenzoic acid (PABA).
20. A composition as claimed in claim 19 wherein the Vitamin
B-complex contains all of said components.
21. A composition as claimed in claim 19 wherein the Vitamin
B-complex comprises the following components dosed per day in the
range indicated:
4 Component Range (per day) Folic Acid 2400 mcg-4800 mcg Vitamin B1
100 mg-200 mg Vitamin B2 100 mg 200 mg Vitamin B3 (niacin) 10 mg-30
mg Vitamin B3 100 mg-300 mg (niacinamide) Vitamin B5 100 mg-400 mg
Vitamin B6 150 mg-350 mg Vitamin B12 100 mcg-200 mcg Biotin 600
mcg-1,200 mcg Inositol 100 mg-200 mg Choline 100 mg-200 mg PABA 100
mg-200 mg.
22. A composition as claimed in claim 1 wherein the mineral is
selected from one or more of the group consisting of: calcium,
magnesium, Vitamin D3, iodine, iron, potassium gluconate, zinc,
Vitamin K, copper, chromium, lecithin, lecithin choline, selenium
and piperine.
23. A composition as claimed in claim 22 wherein calcium is present
in the composition so as to be dosed at between 1500 and 2500 mg
per day.
24. A composition as claimed in claim 22 wherein magnesium is
present in the composition so as to be dosed at between 600 and
1000 mg per day.
25. A composition as claimed in claim 22 wherein potassium
gluconate is present in the composition so as to be dosed at
between 1800 and 5400 per day, the potassium gluconate having about
300 to 900 mg of potassium.
26. A composition as claimed in claim 22 wherein zinc is present in
the composition so as to be dosed at between 60 and 120 mg per
day.
27. A composition as claimed in claim 22 wherein vitamin K is
present in the composition so as to be dosed at between 600 and
1200 mcg per day.
28. A composition as claimed in claim 22 wherein copper is present
in the composition so as to be dosed at between 2 and 8 mg per day,
the copper being linked to an amino acid.
29. A composition as claimed in claim 22 wherein lecithin choline
is present in the composition so as to be dosed at between 3600 and
7200 mg per day, 25% to 50% whereof comprises
phosphatidyloholine.
30. A composition as claimed in claim 22 wherein chromium is
present in the composition as a chromium piconolate complex and is
dosed at between 1200 and 2000 mcg per day.
31. A composition as claimed in claim 22 wherein selenium and
piperine comprise a mixture in an approximately 10:1 ratio
respectively, the mixture having about 300 to 600 mcg selenium and
45 to 100 mcg piperine dosed daily.
32. A composition as claimed in claim 1 wherein the amino acid is
selected from one or more of the group consisting of the following,
and being present in the amount indicated dosed per day:
5 Amino Acid Range (per day) L-alanine 100-300 mg L-arginine
100-300 mg L-aspartic acid 200-450 mg Bromelain 100-200 mg
L-cystine 40-100 mg L-glutamine 400-700 mg glycine 100-200 mg
L-histidine 50-200 mg L-isoleucine 150-300 mg L-leucine 100-400 mg
L-lycine 100-400 mg L-methionine 100-200 mg pancreatin 4X 40-150 mg
papain NF 100-200 mg L-phenylalanine 200-400 mg L-proline 150-350
mg L-serine 150-350 mg L-threonine 100-300 mg L-tyrosine 200-400 mg
taurine 200-400 mg L-valine 200-400 mg.
33. A composition as claimed in claim 32 wherein additional
quantities of one or more amino acids selected from the following
group, and being present in the amount indicated dosed per day, are
present in the composition.
6 Amino Acid Dosage Range L-arginine 3,000-5,000 mg L-glutamine
2,000-4,000 mg L-tyrosine 1,000-2,000 mg glutathione 1,000-3,000 mg
taurine 4,000-8,000 mg ornithine 3,000-8,000 mg.
34. A composition as claimed in 32 further comprising one or more
amino acids selected from the group consisting of:
N-acetyl-L-cystine, L-carnitine, elycosapentaenoeic acid, linoloic
acid, gamma-linoloic acid, docosahexaenoic acid, oieic acid,
palmitic acid, stearic acid, and palmitoleic acid.
35. A composition as claimed in claim 1 further comprising flax
seed oil present in the composition so as to be dosed at about 3000
mg per day.
36. A composition as claimed in claim 1 further comprising lipoic
acid present in the composition so as to be dosed at about 75 to
225 mg per day.
37. A composition as claimed in claim 1 further comprising garlic
present in the composition so as to be dosed at about 750 mg to
1700 mg per day.
38. A method of forming a composition for the treatment of a human
body, the method comprising: providing in combination (a) at least
one hormone; (b) at least one amino acid; (c) at least one enzyme
and/or vitamin; (d) at least one mineral adjusting the relative
amounts of said hormone, amino acid, enzyme and mineral in the
combination to be balanced with respect to each other and present
in effective amounts to substantially restore to optimal levels in
the body said hormone, amino acid, enzyme and mineral, the hormone,
amino acid, enzyme and mineral in the combination operating
synergistically to provide both nutrients and command components to
enable the body to effectively utilize said nutrients.
Description
FIELD AND BACKGROUND OF THE INVENTION
[0001] This invention relates to composition combinations for the
treatment of the human body to both maintain the health of the body
and fight disease therein.
[0002] More particularly the invention relates to various
compositions, including, but not limited to, hormones, vitamins,
enzymes amino acids minerals and other substances found naturally
in the body, and combining them in various forms and dosages
according to the nature of the condition being treated such that
the combination, when administered to a person, restores and/or
creates optimal biochemical levels of the compositions within the
body.
[0003] It is a well-known fact that, as humans age, there is both a
cellular and molecular tissue degeneration. This may be due to the
natural aging process, as well as various forms of disease which
have invaded the body. As the body ages, its biochemical capacity
to fight disease on a molecular level declines. Disease and tissue
degeneration gradually destroy the health of the person, ultimately
resulting in death.
[0004] The present invention addresses this situation by attempting
to alter the body chemistry from that which has allowed the body to
create a medium in which the disease has developed. Many diseases
do not exist or do not develop in young adults in their twenties,
whereas older people in and beyond their sixties will much more
readily support the same disease.
[0005] The present invention is therefore a composition comprised
of various components and substances which modulate the
physiological conditions within the body. The invention is based on
the proposition that altering and correcting the biochemical plane
changes the physiological medium that allowed a disease to exist
may effectively reduce or obviate the disease. The combination of
components which constitute the composition of the present
invention are therefore designed to fight the causes of the
diseases, and not simply to mask their effect.
[0006] The invention is a composition, a method of treatment using
the composition, and a method for formulating the composition
designed to treat the disease at the molecular/cellular level,
focusing strongly on DNA and RNA regulation, RNA template
protection, protection of genes and chromosomes, and enhancement of
the molecular/cellular language which is spoken and understood by
the cells of the body. The invention uses, amongst others, specific
and calculated quantities of hormones, amino acids, amino sugars,
coenzymes, enzymes and mineral ions in an effort to fight disease
and restore the conditions of the body on a cellular level.
SUMMARY OF THE INVENTION
[0007] According to one aspect of the invention there is provided a
composition for treatment of a human body, the composition
comprising a combination of: a) at least one hormone; b) at least
one amino acid; c) at least one enzyme and/or vitamin; d) at least
one mineral wherein the relative proportions of said hormone, amino
acid, enzyme and mineral in the combination are balanced with
respect to each other so as to be present in effective amounts to
substantially restore to optimal levels in the body the hormone,
amino acid, enzyme and mineral, the hormone, amino acid, enzyme and
mineral in the combination further operating synergistically to
provide both nutrients and command components to enable the body to
effectively utilize the nutrients.
[0008] According to another aspect of the invention there is
provided a method of forming a composition for the treatment of a
human body, the method comprising: providing in combination: (a) at
least one hormone; (b) at least one amino acid; (c) at least one
enzyme and/or vitamin; (d) at least one mineral; adjusting the
relative amounts of the hormone, amino acid, enzyme and mineral in
the combination to be balanced with respect to each other and
present in effective amounts to substantially restore to optimal
levels in the body the hormone, amino acid, enzyme and mineral, the
hormone, amino acid, enzyme and mineral in the combination
operating synergistically to provide both nutrients and command
components to enable the body to effectively utilize the
nutrients.
[0009] In one aspect of the inventions there is provided a
composition for treating diseases and cellular degeneration by
modulating the chemistry of the body on a wide ranging
comprehensive level. By this is meant that the combination of
components which constitute the composition address biochemical
deficiencies in the body usually resulting from disease or the
aging process. The composition endeavors to restore to the extent
possible a wide range of biochemical levels of important substances
produced and required by the body and therefore alter the
environment in which disease within the body has been allowed to
develop.
[0010] Depending on the nature of the condition to be treated,
different combinations of substances and the doses thereof may be
used to formulate a regimen to address biochemical deficiencies and
restore a "biochemical platform level" to prevent an environment in
which disease can thrive. The present invention is particularly
effective in treating such conditions as cardiovascular diseases,
auto-immune diseases, Parkinson's disease and the like. The
composition has been shown to work repeatedly, especially in the
treatment of cardiovascular disease. The tables and data based on
actual patient response to the composition of the invention clearly
indicate the positive effect on the body by comprehensive
augmentation of essential and critical biochemical substances.
[0011] The composition of the invention is based on a predetermined
combining of hormones, amino acids, enzymes and minerals. Based on
the condition of the patient, at least these four components are
combined in a composition and ingested so as to provide nutrients
as well as command components to enhance DNA and RNA regulation,
such regulation being sufficient to, at the least, produce tissue
regeneration. "Command components" refers to those components of
the composition which regulate, instruct, manipulate, assist in
cell communication, protect against deterioration, control or
otherwise generally have a function aside from nutrient
requirements. Such components may, however, also have in addition a
nutrient function.
[0012] In one aspect of the invention, the composition for
combining the various components can be expressed as follows:
H.times.A2.sup.+E3+M3a+DRR.gtoreq.TR.
[0013] In the formula above H=hormones; A=amino acids; E=enzymes;
M=minerals; DRR=DNA and/or RNA command regulation; and TR=tissue
regeneration.
[0014] Hormones are the products of living cells and function so as
to produce a specific effect on the activity of cells remote from
the point of manufacture of the hormone. Hormones are secreted into
the body fluids by a cell or a group of cells, profoundly affecting
and controlling the behavior of other cells within the body.
[0015] Amino acids are essential compounds used by the body in the
synthesis of proteins. Amino acids may be synthesized by living
cells within the body, or are obtained by the body as essential
components of the diet. Not all amino acids can be synthesized by
the body. For example, ten amino acids are mandatory and necessary
for life, but are not produced by the body and must therefore be
obtained nutritionally on a daily basis. These amino acids are
arginine, histidine, isoleucine, leucine, lysine, methionine,
phenylalanine, threonine, tryptophan and valine. In addition to the
above, there are a number of non-essential amino acids, the
importance of which may be significantly increased in times of
sickness, stress, disease and as the body ages.
[0016] Enzymes are fairly complex proteins that chemically help in
the transformation of one substance into another inside the cell
and function as catalysts in specific biochemical reactions. The
enzymes are thus catalytic substances, usually protein, and upon
obtaining access to and entering a human cell, either initiate or
increase the efficiency rates of chemical reactions within the
cell. These enzymes alter and may increase metabolism rates within
the cell, including anabolism, the constructive metabolism
concerned with the synthesis of macromolecular structure, and
catabolism, the metabolism resulting in breakdown of complex
materials often with the release of energy.
[0017] Vitamins are generally included in the enzyme category due
to their enzyme-like results and effects on molecular/cellular
structure. Generally, the vitamins will cause an increase in the
rate of chemical inter-reaction within the body.
[0018] Mineral ingestion in acceptable ratios is essential to the
proper functioning of the human body. If the relative ratios of
mineral ions within the body falls out of balance, the normal
function of the body on a cellular level will be greatly impaired.
There are many required minerals controlling in or assisting in a
wide range of cellular operations. Some of the most important of
these minerals include: iron, calcium, potassium, magnesium,
manganese, copper, zinc, iodine, selenium and the like.
[0019] The various components of the composition may be introduced
in quantities and dosages which take into account the patient
condition, age, extent of disease, body chemistry, blood levels and
other relevant factors. Discussed in detail further below in this
application are specific components, and their importance and
possible doses for use within the composition are set out. It has
been found that, using the above formula and based on results of
cardiovascular medical trials, significant cell regeneration is
possible.
[0020] Determining the composition in making up the treatment
composition is based on the accepted understanding that the
function of the human body is a combination of biochemical
interreactions, all forming a complex arrangement whereby these
reactions effect and act out upon one another. By introducing
certain components into the body and thereby attempting to control
the biochemical contact between the cells, the "cellular dialogue"
can be advantageously changed and modulated. To the extent that the
cellular dialogue or conversation can be controlled, for example at
the RNA template, the ability exists to change the course or
direction of the organisms function at the molecular level.
Further, conditions can be changed to emulate those during an
earlier biological time period of the patient, and appropriate
doses of the various components which make up the composition
administered to offset cellular retardation. The body's biochemical
output production may typically drop 10-12% every 4 years on
average, and the ability to introduce various chemical components
into the body in predetermined combinations and dosages addresses
and may reverse this retardation. In effect, therefore, the
composition of the invention to some extent produces a cellular
genesis with the ability to stop and correct tissue degeneration
and/or oxidation By strengthening cellular instructions and
maintaining optimal relative proportions and/or levels of a large
number of biochemical components, the overall biochemical system
may be strengthened and enhanced to regain its ability to fight
disease from an earlier time period. By "optimal relative
proportions" and "optimal levels" is meant the individual's
relative amounts of a wide range of components which were present
during the physiological prime of the body, usually between 18 and
25 years of age.
[0021] Further, the so-called "biochemical medium" of the body may
be corrected and enhanced to reduce or eliminate conditions where
disease can first take hold.
BRIEF DESCRIPTION OF THE DRAWINGS
[0022] FIG. 1 is a table showing a specific regimen administered to
a patient;
[0023] FIG. 2 is a diagram showing start and end NYHA levels for
selected patients; FIG. 3 is a diagram showing start and end blood
pressures for the patients;
[0024] FIG. 4 is a diagram showing start and end pulse rates for
the patients,
[0025] FIG. 5 is a diagram showing start and end total cholesterol
for selected patients;
[0026] FIG. 6 is a diagram showing start and end LDL cholesterol
levels for selected patients;
[0027] FIG. 7 is a diagram showing start and end HDL cholesterol
levels for selected patients; and
[0028] FIG. 8 is a diagram showing start and end triglyceride
levels for selected patients.
DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS
[0029] In one aspect, therefore, the invention comprises a
composition of nutrient and biochemical components for the
treatment of the human body, the composition comprising one or more
of the following: a hormone, amino acid, enzyme and minerals.
[0030] Preferably, the hormone is at least one or both of
dehydroepiandrosterone (DHEA) and melatonin. Vitamin D3 may be used
as prohormone.
[0031] "Enzymes" is intended as an umbrella term and preferably
includes enzymes, coenzymes, vitamins and antioxidants. More
specifically, the enzyme may comprise coenzyme Q-10. The
antioxidants preferably include multi-carotenes alpha, beta and
gamma-carotenes, lycopene, lutein and xeanthin. The enzymes are
also intended to include vitamins, including Vitamin B, Vitamin B
complex, Vitamin C, Vitamin D (other than D3) and Vitamin E.
[0032] The minerals may include a wide variety of compounds used by
the body, including, but not limited to: calcium, magnesium,
phosphorus, iodine, iron (ferrous fumarate), manganese, potassium,
copper, zinc, chromium and selenium.
[0033] When the components are administered as a group in
combination, and constitute a complete regimen of treatment, the
body's physiology may be modulated to emulate its physiology at a
much younger age. The preferred age range to emulate is 18 to 25
years.
[0034] In the first six months of private clinical trials for
patients on the regimen of the present invention, the average NYHA
level improved from 3.1 on average to 1.3 on average. This was
accompanied by improvements in cardiovascular function.
Additionally, patients' blood pressures dropped from 153.7/113 to
101.5/69.6, and the average pulse rate dropped from 104 to 76.
Blood chemistries improved significantly. On average, patients'
total blood cholesterol levels dropped 39.6 mg/dl. LDL-cholesterol
levels dropped 48.3 mg/dl, and HDL-cholesterol levels increased by
14.5 mg/dl. On average, patients HDL/LDL cholesterol ratios
improved by 216%, and triglycerides dropped 29.3 mg/dl. Prior to
the regimen of the present invention, conventional medications were
not able to bring about significant improvements.
[0035] The regimen constituting the biochemical formula of the
present invention may involve supernutritional amounts of nutrients
and "mega" amounts of several hormones. The goal of the regimen is
to restore levels of certain "super hormones" to those of healthy
20-25 year olds.
[0036] Success in areas outside of cardiovascular disease has been
achieved. For example, in preliminary treatment of Parkinson's
disease, symptoms diminished within 24 hours, and, in one
particular instance, within 48 to 72 hours of treatment of the
regimen, no symptoms were noticeable. Pilot studies on Lupus and
Fibromyalgia syndrome, chronic fatigue syndrome and rheumatoid
arthritis have also shown promising results. This application also
describes treatment of arthritis and the success in the treatment
thereof.
[0037] As mentioned above, the regimen or biochemical formula of
the invention involves the use of quantities of nutrients and
hormones in higher range "supernutritional" levels. Many of the
dosages described in this application are designed for persons with
sometimes advanced diseases. The regimen prescribes very high doses
of hormones, amino acids, enzymes, and minerals which are
maintained in a balance. In this regard, it is pointed out that
adding only some nutrients does not achieve the objective. The
regimen attempts to overwhelm the disease, and attack it from as
many different biochemical pathways and direct avenues of approach
as possible to destroy it before it can kill the patient. In
attacking the disease, the use of hormones and chemical messengers
tell the cells what to do. Vitamins, minerals, amino acids,
enzymes, coenzymes and essential fatty acids are prescribed so as
to attack the disease from every biochemical pathway, 24 hours a
day. A very hostile environment is provided so that the disease has
difficulty surviving.
[0038] The dosages prescribed take into account the amount of
deterioration that has occurred in the patient. Deterioration of a
person on a biochemical or cellular level commences past the age of
22 to 25 years. Hormonal production drops, absorbency rates inside
the intestines are dropping and large amounts of toxins, such as
alcohol, may be ingested. The body gets less nutrients, less amino
acids, enzymes and other important nutrients crossing over the
intestinal tract into the bloodstream. Thus, the peculiarities of
the individual are taken into account in establishing the dose
level.
[0039] In establishing the doses, the treatment approach is
different from the conventional medical approach, which asks "what
is there causing cardiovascular disease?". The regimen is based on
the question "what is not there now (for example at 62 years of
age) that allow the causes of cardiovascular disease to develop?".
In other words, the approach is to determine what is missing in the
body that was present in earlier years, and studying these
biochemical levels in a person's prime as compared to what is being
produced and ingested by the body at later times.
[0040] The other approach of the invention is to determine the
driving force in the body. The DNA/genes and chromosomes are, in a
sense, immortal, having come down through the ages and continue to
live in the body in one form or another. Levels of hormones
produced in the body at earlier ages are never duplicated at a
later time, and either turn off or deteriorate in later years.
Thus, controlling and emulating the molecular operation enabling a
person to reach the age of 20-25 years is of prime interest.
Understanding this language involves controlling and regulating
DNA.
[0041] All cells obey the laws of physics and chemistry, so by
manipulating the DNA, instructions are provided in a language so
that tissues are able to regenerate accordingly. Thus, providing an
all encompassing nutrient approach, the DNA is able to function and
produce the necessary substances that maintain the body in a
healthy state at an earlier age.
[0042] The invention looks at cell communication and biophysics.
Looking at the disease and its causes, it is noted that a massive
amount of correlated total bioenergy enabled the body to reach its
biological prime. Massive amounts of very complex biochemical
actions, reactions, interactions and pathways start at one point
and then proceed to complete physical development. Thereafter,
deterioration sets in, resulting in not only a biochemistry
problem, but in a biophysics and physics problem. From conception
through birth childhood, puberty, adolescence, and early adulthood,
a huge correlation of hormones, amino acids and enzymes push and
develop the body. After early adulthood, this flattens out on a
biochemical plateau and then reduction sets in. With this reduction
or contraction, free radical damage, a toxic environment and other
factors contribute to the deterioration. At this point, a
combination of biophysics and biochemistry must be considered to
address the problem on a molecular level. The lack of the
biochemical instructions and resources, along with toxin ingestion
and a host of other problems, cause the system to break down.
[0043] There is no point in feeding the body the necessary
nutrients without providing it with the instructions on how to use
them. Thus, prescribing one "supervitamin" or another is
ineffective, since it takes all vitamins and other substances to
ensure tissue maintenance, regulation and metabolism. Aging results
in the reduction in cellular efficiency and capacity rate, and
intestinal absorbency rates drop resulting in the body receiving
less and less incoming nutrients. For example, a body at one time
is accustomed to providing, for example, 400-450 mcg/100 ml of DHEA
blood level in a mature male approximately 22 years old. In
patients with cardiovascular problems, 0-25 mcg/100 ml of DHEA is
found in the blood. DHEA is simply not there anymore in the
necessary quantities.
[0044] The regimen not only feeds the cell what it needs, but
attempts to supply instruction for the use thereof. Thus, a body
may be able to absorb some of the nutrients but will not be able to
use them to maximum capacity if, for example, the mitochondria of
the cells are not working properly. It would be ineffective to give
a cell overwhelming amounts of nutrients without giving it the
proper directions, from the amounts of hormones and amino acids,
necessary to stimulate them to use the nutrients properly.
[0045] Hormones
[0046] DHEA is one of the most abundant hormones in humans and
mammals and is an essential component in many physiological
functions. It has been found that DHEA is deficient in persons
suffering from major diseases including obesity, diabetes, high
blood pressure, cancer and others. DHEA is manufactured in the body
from cholesterol. While DHEA levels often decline with age,
cholesterol levels have been found to increase with age. (see
"DHEA. The Youth and Health Hormone" C. Norman Shealy, M.D.; 1996
Keats Publishing Inc.).
[0047] In administering DHEA and determining appropriate levels
thereof, the DHEA levels in the patient at between 20 and 25 years
of age are used as a yardstick. In many instances, the target
amount of DHEA is 450 mg/ml of blood for males and 380 mg/ml of
blood for females. A variation of 5% from these levels would be
optimal, although variations up to about 15% -20% may be
acceptable. Since these are the blood levels of DHEA of the normal
male and female in the 22-25 year old age bracket, the dosage of
DHEA used in the biochemical formula of the invention is calculated
so as to augment DHEA levels in the body to these amounts.
[0048] The amount of DHEA to be administered to reach this level
will obviously vary according to the age and condition of the
patient. For example, a 60 year old male patient approximately 5
feet 10 inches in height and 180 pounds in weight will typically
require 100-125 mg of DHEA on a daily basis. Preferably, this
dosage would be administered three times a day to spread the intake
of the DHEA over a 24 hour period. As mentioned above, the amount
of DHEA produced by the body (in the adrenal glands) decreases with
age. Studies appear to indicate that there is a 2.5% decreasing
ratio in this hormonal production rate each year.
[0049] In determining the amount of DHEA to be administered, other
characteristics and attributes of the patient would also be
considered. For example, patient ingestion of alcohol, tobacco,
caffeine and drugs may cause rapid degeneration and destruction of
body tissues, and the extent and duration of such ingestion will
assist in determining the quantities of DHEA to be
administered.
[0050] In general, DHEA doses are preferably between 75-200 mg per
day, varied according to the age and condition of the patient.
Females would usually require about 20% less than males. Target
doses may be prorated to take into account a 2.5% decline per year
in the amount of DHEA produced from the age of about 25 years in
males and 22 years in females. While doses up to 200 mg per day
have been used in clinical trials for very old patients (70 to 80
years or older), doses over 200 mg per day have not been used.
Higher doses would typically be for older patients of large
physical size and stature.
[0051] Melatonin is another hormone which is produced naturally by
the body, secreted by the pineal gland in the brain. Melatonin has
versatile and varied effects, and recent clinical studies have
shown its ability to improve immune functions, reduce or prevent
heart disease, lower cholesterol, as well as slow down the aging
process. Melatonin is also known for its powerful antioxidant
characteristics. Various antioxidants, as well as their beneficial
effects on the body, are discussed below, but in general terms, an
antioxidant assists in stemming the damaging effects of the free
radical chain-reaction in the body, which may damage cell
membranes, cell bodies and chromosomal material.
[0052] Melatonin is preferably administered in doses ranging
between 5 mg and 12 mg per day. However, doses may start lower than
this, and may be 3 mg per day or less. The patient is preferably,
over a period of time, administered increasing doses of melatonin,
preferably up to between 5 mg and 8 mg per day. Additionally, the
regimen of the present invention is such that the melatonin is
taken only once a day, at dusk local time, since optimal results
have been noted when melatonin is taken at this time. The regimen
requires that melatonin be administered to duplicate normal ratios
of about 10.1, but variation in this ratio is possible. Indeed,
some patients obtain positive responses and healthy results when
the ratio is adjusted to a different ratio +/-25% of the original
target ratio.
[0053] Optical effects and advantages are obtained when the doses
of the various components which form the regimen of the invention
are fairly evenly divided and taken in three separate medications
over the course of the day. The doses may be taken at the
conventional times, namely, morning, noon and at evening or dusk.
There are, however, certain exceptions to this general approach,
particularly with respect to the melatonin dosage discussed above,
which is optimally taken only at dusk.
[0054] Enzymes
[0055] Coenzyme Q10 also known as ubiquinone, is commonly found in
humans and is utilized in the human body for its energy properties.
It is to be noted here that there are a variety of molecular
formulations ranging from Coenzyme Q6 to Coenzyme Q-10, although
only the Coenzyme Q10 is found in humans. However, animal forms of
this coenzyme can be converted to Q-10 when ingested as part of the
die. Therefore, while this patent application typically refers to
the administering of Coenzyme Q-10, it is within the scope of the
invention to use other formulations of this coenzyme.
[0056] Enzymes usually consist of two portions, namely a protein
portion otherwise known as an apoenzyme, and a cofactor portion.
The apoenzyme is constituted by a string of amino acids which find
their basis in the chromosomal material. The other non-protein
portion or co-factor portion of the enzyme is often called a
coenzyme.
[0057] Coenzyme Q-10 plays a significant role in the Krebs or
citric acid cycle resulting in the production of an energy-rich
compound called adenosine triphosphate, abbreviated as ATP. The
energy contained within the compound ATP is dispensed to and used
by the body to carry out normal functions. When dispensing the
energy, ATP releases a phosphate group, and approximately 7,000
calories of energy, and is converted to adenine diphosphate, or
ADP. The ADP, in turn, upon receiving energy from food and
nutrients in the body, is once more converted to ATP, thus forming
the energy cycle and constituting the generator or power base of
the body.
[0058] The main site of ATP production is in the mitochondria of
the cell. Administering doses of the various components
constituting the regimen of the invention have an immediate effect
at the cellular level, transmitting instructions to the
mitochondria within the cells. These mitochondria are
double-membraned organelles of the cell cytoplasm that process
cellular energy by the oxidation of substrates, and store it in the
form of ATP, as discussed above. The metabolism of the cell depends
on a constant supply of incoming "raw materials" available for
continual use. Furthermore, the cycle requires the removal of
finished substances and the waste products of these interactions by
the circulation of the blood. In this way, each cell operates as a
small power plant, with three stages of energy production
operations. These are: provision of raw materials, manufacture of
the energy by using the raw materials in converting ADP to ATP, and
the disposal and discharge of the waste byproducts. The entire
operation is controlled by the cell nucleus and maintained by the
available energy reserves.
[0059] Coenzyme Q-10 is a critical component in the creation of
cellular energy within the cell, and it has a direct effect and
enhances the activity of the mitochondria within the cell. The
highest concentrations of Coenzyme Q-10 can be found in the heart,
while lesser amounts are found in other organs such as the liver,
brain lungs etc. The daily dosage of the Coenzyme Q-10 preferably
varies between 240 mg and 600 mg. A preferred middle range is
between 360 mg and 540 mg. Once more, the amount of the dosage will
depend on the particular condition of the patient, and since
Coenzyme Q-10 is a critical component in the treatment of
cardiovascular disease, the extent of development of the
cardiovascular disease, within the patient, the condition of the
heart, and the "NYHA" (New York Heart Association) level of the
patient will all be taken into account. This is in addition to the
normal parameters such as the height, weight and age of the
patient, in determining the optimal dosage for administration.
[0060] Antioxidants
[0061] Generally, antioxidants are compounds that sacrifice
themselves to oxygen. Antioxidant compounds have chemistries that
allow them to react readily with oxygen. The ease of this reaction
enables antioxidant compounds to react with the free radical
generators, and quench free radical production. A free radical is
an incomplete highly reactive molecule capable of destroying an
enzyme, protein, genetic material or even an entire cell over time.
Additionally, the free radical usually generates a chain of free
radical reactions resulting in thousands of free radicals being
released to destroy the cell components. This process is called
biological magnification. The antioxidants not only help protect
the body against the destructive effects of these free radicals,
but also stimulate the immune response to help fight existing
disease, and they tend to normalize the balance of hormone-like
chemicals in the body. ("The Antioxidants--The Nutrients that Guard
Your Body" by Richard A. Passwater, Ph. D., 1985, Keats Publishing
Inc.).
[0062] The antioxidants therefore protect and repair cellular
tissue from this free radical damage. Some important antioxidants
are, but not limited tog the following multi-carotenes,
beta-carotenes, alpha-carotenes, gamma-carotenes, lycopene, lutein
and zeanthins. Further antioxidants include Vitamin E, Vitamin C
and Niacin. The use of these antioxidants helps to preserve not
only the chromosomal genetic material against breakdown, but also
proteins, enzymes and other substances within the body. Since
destruction or damage of chromosomal material within the cell has a
direct impact on the future ability of that cell to produce
functional and effective proteins and enzymes, the need to protect
the body from the free radicals is an important one.
[0063] The composition of the present invention preferably includes
multi- and single-carotenes. Preferably, 50-60 mg of beta-carotene
per day, 25-40 mg of alpha-carotene per day, 1-5 mg of
gamma-carotene per day, 1-5 mg of lycopene per day, 1-10 mg of
lutein per day and 200-500 mcg of zeaxanthin/astaxanthan per day
are administered. Depending on the body characteristics and
condition of the patient, these amounts may vary by 30% -40%.
[0064] With respect to the carotenes, the clinical results show
that they function most effectively when used together in a united
effort. Research has shown that by supplementing with just one of
the carotenoids, such as beta-carotene, levels of other carotenes
in the body may actually be reduced. Alpha-carotene has been found
to be more effective than beta-carotene for free radical attacks on
the cells, and promoting cellular health on the molecular level.
Further, alpha-carotene remains in the carotene form almost twice
as long as beta-carotene, so that the antioxidant properties
thereof work for a longer period of time inside the body.
[0065] Lycopene is an extremely efficient carotenoid which is
significantly more effective than others. Lycopene appears to be
almost twice as effective as the beta-carotene and one hundred
times better than and/or stronger than Vitamin E at fighting free
radicals and the damage that they cause. The mixture of the
carotenoids, generally as indicated above, plus the use of
lycopene, increases the cellular resistance and maintains and
supports proper tissue health. These are a highly effective
combination of antioxidants, having the effect of first increasing
and then maintaining overall cellular health tissue.
[0066] The regimen may also include alpha-, beta- and gamma-
Vitamin E, preferably given in doses of 800-4,000 IU per day. More
normal ranges may preferably fall between 2,000 and 3,000 IU per
day, depending on patient characteristics. The regimen further
includes Vitamin C, with daily dosage ranges between 1500 mg and
4,000 mg. Once more, a more normal range will preferably fall
between 2,000 and 3,000 mg.
[0067] The various dosages of the carotenes, Vitamin E and Vitamin
C mentioned above are typically given three times per day, morning,
noon and evening, in substantially equal dosages.
[0068] Vitamin B3, or niacin, is one of the more stable B vitamins,
and is the common name for two compounds, namely, nicotinic acid
and nicotinamide. Niacin is an important component in the
biochemical formula of the invention in that it plays many diverse
and critical roles in the cells of the body, both supplying energy
and maintaining the integrity of the body cells. Although niacin is
synthesized in the liver of the body, from the amino acid
tryptophan, the body's demand and need for niacin is strong, and
increases with age. The use of niacin is important particularly in
the treatment of cardiovascular diseases. The normal body requires
a healthy balance of HDL and LDL cholesterol, since this is
essential for cardiovascular health and function. The niacin dosage
within the biochemical formula helps to control the body's
production of VLDLs (or very low density lipoproteins) which are
proteins used by the body to create LDLs. The LDLs are bad for the
body, and constitute the destructive cholesterol molecule,
[0069] Typically, the form of niacin used may produce a flushing,
redness or rash to the skin when consumed in large doses. This has
been found to be due to the biochemical reaction produced by such
niacins and resulting in the sudden release of prostaglandins. The
present invention has been able to use these larger doses, but with
no side-effects, by using niacin which contains inositol
hexanicotinate. Inositol is molecularly bonded to niacin, and in
conjunction therewith serves to slow the absorption of nicotinic
acid. This effectively eliminates or substantially reduces the
flushing or rash in the skin of patients. In this way, effective
amounts of niacin inositol hexanicotinate can be administered
without the adverse skin side effect, to reduce the LDL levels,
stabilize HDL levels and lower, overall, cholesterol and
triglyceride levels.
[0070] In the biochemical formula of the invention, preferably
about 400 mg to 1,600 mg per day of niacin inositol hexanicotinate
is administered, with the preferred range being between 800
mg-1,200 mg per day. As with most of the other components of the
composition, the niacin inositol hexanicotinate is administered
three times a day, morning, noon and night, in approximately equal
doses.
[0071] The composition of the present invention preferably includes
a Vitamin B complex, which preferably, but not necessarily,
comprises all of the following components: folic acid, Vitamin B1,
Vitamin B2, Vitamin B3 (niacin), Vitamin B3 (niacinamide), Vitamin
B5, Vitamin B6, Vitamin B12, biotin, inositol, choline and
para-amino benzoic acid (abbreviated PABA). The combination of the
various components which constitute this Vitamin B complex is
administered to provide all or most of the essential B-complex
vitamins which are required resources for the operation of the
nervous system and the adrenal glands.
[0072] Research has shown that the primary defense mechanism of the
immune system against stress are products of the adrenal glands.
These glands secrete hormones directly into the bloodstream. Each
gland is divided into two parts, namely, an inner medulla and an
outer cortex. The medulla section produces two types of hormones
and takes all of its cellular instructions from the nervous system.
The cortex produces and secretes the hormones called
corticosteroids, which affect the way foods are stored, processed
and used inside the body. The adrenal glands also have a direct
linkage to healing mechanisms inside the body, and strengthen the
response and function of the immune system. However, the complex
vitamins are water soluble, and are quickly excreted from the body.
Therefore, the regimen of the invention requires that the
biochemical levels of these components of the Vitamin B complex be
maintained in order to assist on an ongoing basis the fighting of
the disease. This entails frequent administering of the vitamin B
complex on a regular basis to replace those which are dissolved and
excreted by the body.
[0073] The various individual B vitamins operate as discrete units
to support nerve and brain tissue function, and also assist the
body in coping with stress. As a group, they also complement each
other and act as coenzymes involved in the cellular production of
energy. When one of the essential B vitamins is not present, or is
only present in low concentrations, the response of other
pro-Vitamin Bs may also be reduced and weakened. Further, reduced
concentration or absence of a particular B vitamin may cause an
imbalance to occur when these B vitamins compete with each other
for absorption into the intestine. The particular Vitamin B complex
used in the regimen of this invention, the contents of which are
set forth above, and the various doses of which are described
below, are designed to be highly comprehensive, and are balanced to
ensure maximum transfer and absorption into the intestines.
[0074] The Vitamin B complex advantageously is made up of the
following components, each present in the proportions and dosages
indicated:
1 Approximate Normal Component Preferred Range (per day) Quantity
(per day) Folic Acid 240O mcg-4800 mcg 3600 mcg Vitamin B1 100
mg-200 mg 150 mg Vitamin B2 100 mg-200 mg 150 mg Vitamin B3
(niacin) 10 mg-30 mg 15 mg Vitamin B3 100 mg-300 mg 150 mg
(niacinamide) Vitamin B5 100 mg-400 mg 300 mg Vitamin B6 150 mg-350
mg 225 mg Vitamin B12 100 mcg-200 mcg 150 mcg Biotin 600 mcg-1,200
mcg 900 mcg Inositol 100 mg-200 mg 150 mg Choline 100 mg-200 mg 150
mg PABA 100 mg-200 mg 150 mg
[0075] The Vitamin B complex, when administered in effective doses
and ratios with respect to each other, nourishes and supports the
nerve and brain tissue facilitating proper mental function.
Furthermore, the Vitamin B complex provides the correct support for
proper metabolic function of the body's immune system, and helps
the body effectively manage stress, fatigue and tension.
Importantly, too, the Vitamin B complex provides a solid chemical
base of support for a properly functioning cardiovascular
system.
[0076] Folic acid is one of the components of the Vitamin B complex
mentioned above. Folic acid has been found to enhance and support
healthy cardiovascular function by helping the body get rid of the
toxin homocysteine. Homocysteine (an amino acid) is produced
naturally through digestion, but the agina process increases the
quantities in which it is produced, which in turn has a direct
effect on healthy cholesterol levels. It has been shown that folic
acid supplementation is likely to bring down homocysteine levels,
along with the risk of heart attack, stroke or other blood vessel
problems.
[0077] Inositol also forms part of the Vitamin B complex described
above, and produces a form of niacin which is safe in that it does
not produce flushing or rashes. Inositol also supports
cardiovascular health by helping the body to regulate cholesterol
levels to lower levels found in the body during earlier years.
Biotin assists and supports energy production inside the cell and
helps convert the folic acid into its biologically active form.
Choline, which is a constituent of acetylcholine, is a neuro
transmitter that aids in the proper transmission of brain waves and
therefore facilitates brain function. PABA, another component of
the Vitamin B complex, assists the body in its use of pantothenic
acid, which supports and enhances the formation of red blood cells
and acts as a coenzyme in the breakdown and utilization of
protein.
[0078] It will therefore be appreciated that the vitamin B complex
addresses a multitude of the body's functions and biochemical
components to restore the level of these components to former
levels when the body was able to withstand and better fight many
diseases. The regimen adopts an "across the board" approach in
addressing multiple body biochemistries, all of which, when
functioning properly, enhance and augment each other for the
general well-being of the body.
[0079] Minerals
[0080] The composition of the invention also calls for the use of
minerals and mineral ions, since the ingestion of these minerals,
as well as maintaining proper ratios thereof within the human body,
is a prerequisite to correct and normal functioning of the body at
a cellular and tissue level.
[0081] Calcium and magnesium work together and cooperatively
support a number of body functions. Together, they help support
nerve transmission, and are also required in the regulation of
energy levels. These minerals are also required to help and
maintain heart function and have a direct effect on maintaining
proper blood pressure levels. Calcium is needed to facilitate
effective blood-clotting, and it has an enzymatic action. It is
further used in neuromuscular excitation, and for maintenance and
function of the cell membrane. Further, it is used in the
activation of hormonal secretion.
[0082] Vitamin D facilitates the absorption of calcium through the
intestines into the bloodstream. The calcium, as is well known, has
a major role in supporting bone density and strength. Proper
intakes of calcium assist in the prevention of osteoporosis, a
problem related to age, and found particularly in cardiovascular
patients. Women can lose up to 15% of total skeletal mass within 5
to 10 years following menopause, and it is also during this time
period that cardiovascular disease may start to take hold and
develop. Proper intake of calcium, alone and in the proper ratios
with other components, may play a significant role in reducing or
eliminating these problems.
[0083] The daily regimen of the invention preferably includes about
1500 mg-2500 mg of calcium, about 600 mg- 1000 mg of magnesium and
about 600 IU-1000 IU of Vitamin D3. Typically, a preferred dosage
would be about 2000 mg of calcium, 800 mg of magnesium and 800 IU
of Vitamin D-3, with variations and proportions being adjusted to
conform to the particular condition and characteristics of the
patient. Variations of 35% higher or lower than those doses set
forth above would be appropriate depending on the patient.
[0084] The biochemical formula also requires RDA levels of iodine
and iron (RDA=recommended daily allowance). Iodine and iron would
normally be administered twice per day, namely, once in the morning
and once in the evening, although any time during the 24 hour
period would be acceptable.
[0085] Potassium gluconate is another mineral which will form part
of the biochemical formula, and would preferably be dosed between
1,800 mg-5400 mg per day (300-900 mg of element potassium) with a
variation of 20% each way depending upon the condition and
particular characteristics of the patient.
[0086] Potassium is an extremely important component, and is an
essential mineral for proper cardiovascular and neurological
function. Potassium not only assists in the regulation of blood
pressure throughout the cardiovascular system, but increases the
efficiency of neurological firing of nerve transmission impulses
when maintained at optimal levels. Proper quantities of potassium
stabilize and lower the heart rhythm rate. Further, potassium plays
an important role in biochemical reactions resulting in the
secretion of hormone actuates.
[0087] Another important function of potassium is to decrease
sodium levels in body tissue, on a cellular and a molecular level.
While sodium is needed by the body, excess amounts thereof may
cause cellular tissue destruction. The potassium ion molecule has
the ability to enter the cell and lock onto the sodium ion making
its removal possible. The potassium then "escorts" the sodium from
the cells throughout the bloodstream, storing it in the liver for
further removal. There it is processed into bile salts and passed
into the large intestine where it is excreted from the body.
[0088] By using potassium to remove sodium, kidney function is also
improved. While the hormone aldosterone helps regulate the amount
of sodium inside the body at any given time, the aging process
results in the reduced production of this hormone and, therefore,
sodium is not as readily removed from the kidneys at a more
advanced age (such as 65 years or older) as it was at 25 years.
Therefore, the regimen of the present invention uses potassium
particularly on older patients for this purpose.
[0089] Controlling sodium levels in this regimen by the use of
potassium, also lowers blood pressure. While it is a routine
practice of medical doctors to advise lower salt intake to reduce
high blood pressure, the present invention attempts to address and
give assistance to the problem of higher sodium by restoring and
balancing levels of potassium.
[0090] In this invention, typical potassium doses may be preferably
between 75 mg-200 mg or more three times per day. In certain
instances, 1,00 mg-1200 mg or more of potassium per day may be
ingested to maintain the balance referred to above. The doses are
preferably spread out during the day in order to reach and maintain
the optimal effect.
[0091] A preferred aspect of the present invention is the
administering of potassium when bonded or chelated with an amino
acid or a simple sugar. For example, potassium gluconate, as shown
in clinical trials, has better absorbability and assimilation into
the bloodstream.
[0092] The inventor has noticed other advantageous effects in the
use of potassium. Proper levels of potassium assist in the lowering
of cholesterol levels, and also help reverse or slow down the loss
of protein in the urine (proteinuria). This is believed to be the
result of the interaction in the kidneys flowing from the proper
ratios of potassium, sodium and several hormones, including
aldosterone.
[0093] Possible signs of potassium deficiency include a loss of
feeling, numbness or a tingling sensation in the feet, legs, arms
or hands, and the ingestion of potassium to appropriate levels may
address this problem. Further, muscular weakness, fatigue or
lethargy, another age-related health problem, can be improved with
the use of potassium. Improvement in the transmission of nerve
messages and the enhancement of the muscular tissue itself are some
of the important results of increased levels of potassium.
[0094] Doses of potassium in excess of 1,000 mg spread out through
the day, divided in equal doses, are not highly recommended unless
improvements are not maintained in which case much higher doses can
be used. Less potassium is absorbed by older or aged patients, with
the absorbability rate being from 60% -85% less than in a person of
22 years of age. In younger persons, potassium intake is generally
through the small intestinal wall, and the amount of absorption
greatly decreases with age. This may be one of the reasons why
older patients tend to suffer from cardiovascular and circulatory
problems.
[0095] Another advantage of potassium is its effect when forming a
biochemical interface with anti-diuretic hormones (also called
vasopressin) and norepinephrine. These hormones, produced by the
pituitary gland, have a direct reaction on the kidneys to increase
the reabsorption of water. Potassium causes a counter-balancing of
the effects of these pituitary hormones, and is most important for
the functioning of the normal kidney, in order to correct the
amount of discharge of toxins, and maintain proper blood pressure
levels.
[0096] Zinc is found in all cells in the body, and is an integral
component of over 200 enzymes. Zinc is highly concentrated in red
and white blood cells and contributes to the proper functioning of
a number of hormones. For examples zinc has been shown to affect
the hormone dihydrotesterone (DHT) which, at elevated levels, has
been linked to prostrate gland enlargement. Zinc's role in
supporting and maintaining proper levels of this hormone is
significant since research indicates that more than 50% of all men
between ages 40 and 60 have elevated DHT levels.
[0097] Moreover, zinc is abundant in the bone, kidneys, liver,
pancreas and the retina. It plays a major role in supporting the
immune system, interacts in the antioxidant metabolism, and is
involved in the metabolism of energy on the cellular level, as well
as the synthesis of DNA and RNA in the cell nucleus.
[0098] In administering zinc, it is often advantageous to link it
with an amino acid, and a mixture of zinc with arginate,
histidinate and gluconate (preferably in proportions of about 50%
25% and 25% respectively) enhances its effect. Zinc may be given in
doses of 90 mg per day, However, doses in excess of about 120 mg
per day of chelated zinc can adversely impact LDL levels, which
could increase.
[0099] The biochemical formula of the invention also calls for the
inclusion of Vitamin K, and 600 mcg-1,200 mcg may be the normal
range, with a preferred amount being approximately 900 mcg, again
depending on the condition and characteristics of the patient.
[0100] Copper, also preferably linked to an amino acid, for example
50% gluconate and 50% lycinate, may be used, and may be
administered with the zinc. Up to 6 mg of copper may be the normal
dosage, with variations between 20% and 35% each way.
[0101] Advantageously the composition of the invention includes
lecithin and/or lecithin choline. Lecithin is a natural source of
choline, a substance required for transmission of information
between nerve cells. It has been found that approximately 19 g of
lecithin provides approximately 27 mcg of choline. 3600 mg-7200 mg
of lecithin choline is administered daily. Approximately 25% -50%,
preferably about 35% of this dose comprises phosphatidylcholine,
which has about three times the concentration of choline. Lecithin
is important in the maintenance of cell membranes, keeping them
from hardening and preventing damage caused by oxidation. The fatty
protective sheaths that surround the nerves in the brain and muscle
cells all contain large amounts of lecithin.
[0102] Lecithin provides the body with a form of choline known as
phosphatydal choline. This choline is normally made by the liver,
but natural levels decrease with age. Therefore, supplementing
choline is most important in order to restore the chemical levels
in the body to physical prime levels at about 20 to 25 years of
age.
[0103] Choline has important functions within the body. For
example, the choline in lecithin acts as a lipotropic agent,
ensuring proper transport and metabolism in fats. Further, choline
is needed to make acetylcholine, a neurotransmitter in the brain,
adequate amounts of which are critical for optimal nerve activity
and normal mental and memory functions. Lecithin is also high in
phosphorus, and combines with iron, iodine and calcium, the
importance of which have already been described above in enhancing
and supporting brain function.
[0104] Chromium is an essential trace mineral, and plays a vital
role in sensitizing the body's tissue to the hormone insulin. In
turn, insulin maintains the normal nutritional metabolism of
protein/carbohydrate. Chromium is preferably administered in
chelation with picolinic acid to form chromium picolinate. It
regulates the metabolism of proteins, fats and especially
carbohydrates and helps return cholesterol levels to healthy/normal
levels. Chromium piconolate would normally be administered at
between 1,200 mcg and 2,000 mcg per day. A typical range would
preferably fall between 1400 mcg and 1800 mcg, A preferred
administration would be 3 doses, morning, noon and evening, of
about 400-600 mcg each.
[0105] The composition may include selenium and piperine,
preferably as a mixture, and advantageously wish a ratio of
selenium:piperine at 10:1. While other ratios may also be
appropriate, tests to date have found the 10:1 ratio to be an
effective one. The mixture, in typical form, may therefore comprise
about 300 mcg-600 mcg selenium and 45-100 mcg Piperine per day,
spread morning, noon and night. Some patients, due to their
physical condition, would be more effectively dosed at 400 mcg
selenium to 40 mcg piperine. Variations of up to 25% or more may be
appropriate, again depending on the condition of the patient. Doses
as high as 600 mcg selenium and 60 mcg piperine have been used in
trials for certain patients, but as soon as the patient reaches the
threshold of improvement, doses are lowered in order to return them
to normal range levels.
[0106] Amino Acids
[0107] Set forth below is a table indicating the various amino
acids which are preferably incorporated within the regimen, a
preferred range of dose of the amino acid, and a particular dosage
which may be suitable for an average weight and height male
approximately 60 years old. The amino acids are as follows:
2 Amino Acid Preferred Range Particular Dosage L-alanine 100-300 mg
180 mg L-arginine 100-300 mg 162 mg L-aspartic acid 200-450 mg 320
mg Bromelain 100-200 mg 150 mg L-cystine 40-100 mg 69 mg
L-glutamine 400-700 mg 555 mg glycine 100-200 mg 144 mg L-histidine
50-200 mg 123 mg L-isoleucine 150-300 mg 213 mg L-leucine 100-400
mg 291 mg L-lycine 100-400 mg 231 mg L-methionine 100-200 mg 75 mg
pancreatin 4X 40-150 mg 75 mg papain NF 100-200 mg 150 mg
L-phenylalanine 200-400 mg 264 mg L-proline 150-350 mg 246 mg
L-serine 150-350 mg 213 mg L-threonine 100-300 mg 177 mg L-tyrosine
200-400 mg 309 mg taurine 200-400 mg 270 mg L-valine 200-400 mg 291
mg
[0108] All of the above amino acids are preferably contained within
a multi-amino acid capsule, with the dose indicated taken 3 times
per day. These are normal ranges, although variation above and
below the amount given up to approximately 35% would be appropriate
when taking into account the particular condition and
characteristics of the patient.
[0109] The regimen of the present invention also preferably
includes additional doses of amino acid, as follows:
3 Amino Acid Dosage Range Particular Dosage L-arginine 3,000-5,000
mg 4,500 mg L-glutamine 2,000-4,000 mg 3,000 mg L-tyrosine
1,000-2,000 mg 1,500 mg glutathione 1,000-3,000 mg 1,500 mg taurine
4,000-8,000 mg 6,000 mg ornithine 3,000-8,000 mg 6,000 mg
[0110] These additional doses are the amounts to be given during a
day, with variation according to the particulars of the patient
allowing for up to 35% each way. The dosages given above for the
additional amino acids to be given are the total amounts to be
taken in a day, so that each dose indicated would be divided
approximately into three portions each taken three times per
day.
[0111] Other amino acids also preferably form part of the regimen.
N-acetyl-L-cystine may be administered in doses between 2,000 mg
and 4,000 mg per day in totals preferably at around 3,000 mg. This
total dosage may be divided into three equal parts, with a
variation of about 35% in the dosage range.
[0112] Other amino acids which may form part of the regimen include
L-carnitine, of which between about 1000 mg and 2,000 mg preferably
forms the total daily dosage divided into three equal portions.
Once more, a variation of about 35% or more on the doses may be
appropriate according to the patient. Elycosapentaenoeic acid in
the amount of 400 mg-700 mg per day, with a preferred dosage of
240-540 mg, may be given, while docosahexaenoic acid may also be
provided in ranges of 250 mg-450 mg per day, preferably at around
300 mg.
[0113] In addition, doses of the following amino acids may be
provided linolenic acid at about 1,125 mg per day; gamma-linolenic
acid at about 1,125 mg per day; gamma-linolenic acid at about 687
mg per day; oleic acid at about 570 mg per day; palmitic acid at
about 342 mg per day; stearic acid at about 123 mg per day; and
palmitoleic acid at about 12 mg per day. All of the above may vary
by up to 50%, taking into account the exigencies of the patient.
Linolenic acid, an omega-6 essential fatty acid, has been found to
be most important for proper prostaglandin formation. These are
necessary for the function of the cardiovascular, immune, muscular
and nervous systems.
[0114] Flax seed oil is preferably administered in the amount of
about 3,000 mg per day, divided into three separate doses of about
1000 mg each. Flax seed oil contains omega-3 and omega-6 essential
fatty acids, and a mixture of both animal and grain-based omega-3
and omega-6 fatty acids are used. Flax seed oil assists in the
production of prostaglandins which dictate, on a biochemical level,
the instructions for reduction of and return to proper levels of
blood cholesterol and blood triglyceride levels. Further, they
assist and support in immunology system functions. Dosages may be
decreased or increased by up to 35%, according to the patient.
[0115] The regimen incudes administering lipoic acid in the amount
of 150 mg per day, with normal range variations being up to 50% or
more. Lipoic acid is most important for the production of energy.
It is also most important as a metabolic antioxidant. It helps
convert calories into useful energy, and directs such calories away
from fat production and storage. Lipoic acid also assists in
normalizing blood sugar levels and reduces glycation, which is the
damage resulting from sugar to critical body components. This
damage may lead to accelerated aging, heart disease, and has a
profound negative effect when the patient suffers from
diabetes.
[0116] Other contents of the regimen not falling directly into any
specific class include garlic, preferably administered in the
amount of about 1,200 mg per day but with normal ranges varying 35%
or more above or below this amount. The garlic should include
allicin in the approximate amount of 10,000 mcg per gram, once
more, with the variations of 35% or more, depending on the patient.
Garlic inhibits the enzymes involved in the synthesis of
cholesterol in the liver. It also reduces triglycerides, a type of
fat stored in the body by decreasing fat absorption. Allicin and
ajoene are two of the major constituents of garlic and have a
powerful action which support the body's immune system to fight off
bacteria and diseases. Garlic helps and assists the patient to have
more normal and healthy blood pressure levels and lower cholesterol
levels.
EXAMPLES
[0117] Patient A
[0118] Patient A has been treated by the regimen of the invention
for severe cardiovascular disease which almost claimed his life
during November and December 1996. Patient A had been on the
regimen format and had shown significant recovery. Improvement was
almost immediate, i.e. within 48 hours. The patient is now able to
ride a bike 6 miles per day. The patient, now approximately 60
years old, had beer receiving conventional medical treatment for
cardiovascular disease without any significant effect. The patient
has gone from NYHA (New York Heart Association) level 4 to level
0.
[0119] In FIG. 1 hereof there is shown a Table setting forth the
regimen prescribed and administered to Patient A and which resulted
in the significant health improvement. As will be noted, the
regimen included hormones, amino acids, enzymes, (including
coenzymes, antioxidants, vitamins and the like) as well as
minerals, mineral ions and garlic, using the various dosages
described above. The regimen attempts to optimize biochemistry on
the cellular level by providing proper ratios and proportions of
the various components normally present in a healthy body so that
the effect of each is enhanced in a symbiotic manner.
[0120] Patient B
[0121] The patient was suffering form arthritis, and responded in a
substantial and immediate to the regimen of the invention. The
arthritis caused pain to the extent that the patient had to carry
her left elbow with her right hand. The patient has had arthritis
for about 10 years, starting in the lower spine, and then moving
onto the hands and elbows.
[0122] Patient B is being treated with a standard regimen, and in
addition increased amounts of pregnenolone, chrondroitin, sulfate,
glucosan, glucosomine sulfate and melatonin levels. Noticeable
signs of recovery and improvement were prompt, and within 48 to 72
hours of first ingesting the regimen, reductions in pain level and
swelling in the elbow were evident.
[0123] Patient C
[0124] This patient is an 82 year old male approximately 70
kilograms, with diabetes and anginal pain on exertion with
associated shortness of breath. Over the last 10 years the patient
has become dependent on doses of 20-40 units per day of an insulin
blend.
[0125] Administration of the regimen of the present invention
showed certain distinct improvements including NYHA classification
status from between 2 and 3 to between 1 and 2; and a reduction in
blood pressure from 140/110 to 130/90.
[0126] Patient D
[0127] This patient is 39 years old, 5 Foot, 11 inches in height,
195 pounds in weight with chronic high pulse rate. At testing, the
patient was taking Vitamin C, Vitamin E and beta-carotene. While
blood pressure range was fairly normal, pulse was between 95 and
103, increasing significantly when exercising on a stair machine.
During exercise, the pulse increased to a 170 BPM (beats per
minute) maintained during the entire exercise duration of 20 to 30
minutes. After exercising the pulse rate would return to the
earlier range of 95 to 100 BPM.
[0128] The patient received 100 mg of garlic, with 10,000 mcg of
allicin per gram, 400 mg of niacin (inositol hexanicotonate) and
1,195 mg of potassium gluconate. Within about 1 hour, the pulse
rate had dropped to about 84 BPM. 3.5 hours after ingestion, the
pulse rate had reduced to 78 BPM, a reduction of more than 25 BPM
over a 3.5 hour period.
[0129] The following day, the patients higher pulse rate had
returned to between 95-105 BPM. The patient was readministered with
doses of 800 mg of garlic, 800 mg of niacin and 1,190 mg of
potassium gluconate. Upon once more exercising, the pulse rate was
30-35 BPM less than before using the regimen set forth above. Pulse
had dropped from a normal of 170 BPM to a range of 135-140 BPM
during exercise, a 20% drop from the previous day when no
medication was taken.
[0130] Patient E
[0131] This patient is an 86 year old male approximately 63
kilograms in weight. Patient has experienced progressive cardiac
failures is bedridden and is unable to move without being
breathless. Patient NYHA classification status was 4. Further,
signs of cardiac failure were present.
[0132] The patient started the regimen of the invention and was
followed up approximately one month later. The NYHA status had been
reduced to between 2 and 3, while evidence of cardiac failure had
disappeared. Previous evidence of edema was absent. The pulse rates
had reduced from 120 BPM to about 60 BPM, and blood pressure was at
a normal 120/80 about 60 days after the regimen commenced. The
patient was able to be partially active, was able to move and carry
out body functions independently and was sufficiently mobile to go
out of his house on day-to-day activities. Cardiac function had
improved considerably.
[0133] FIGS. 2-8 show the advantageous effects of the regimen on up
to 23 patients, measuring various parameters.
[0134] In FIG. 2, results of a cardiovascular clinical trial are
shown, indicating the NYHA status at the start, and the NYHA status
6 months after the regimen commenced. There is an overall
significant improvement in the NYHA status of most of the
patients.
[0135] FIG. 3 shows changes in blood pressure at the start, and 6
months into the treatment, and, once more, improvements, often
substantial, are indicated.
[0136] FIG. 4 is a graph showing Pulse at the start of the program
and 6 months into the regimen. Once more, significant reductions in
pulse rate measured in `beats per minute` are shown for those
patients on the regimen.
[0137] FIG. 5 shows total cholesterol measured in certain patients
at start and 6 months into the regimen. Reductions in cholesterol
levels are indicated. In FIG. 6, a table showing the same patients
as indicated in the previous Figure illustrating the LDL
cholesterol changes shown between start and 6 months, while in FIG.
7 a similar table indicates the changes in HDL cholesterol.
[0138] Finally, in FIG. 8, the change in triglycerides was measured
between start and 6 months into the regimen, and reduction in
triglyceride levels was shown in all of the patients.
[0139] The composition or biochemical formula which is the regimen
of the invention constitutes a totally pervasive attack against a
disease, and attempts to overwhelm the disease within the body from
many different angles, pathways, approaches and the like. The
approach is to change the sick body patient biochemistry quickly
and massively and where possible, restore various biochemical
levels, on a wide platform basis, to those seen in an earlier time
period of the person's life. During that earlier time, the body was
far better able to fight disease and create a medium where many
diseases found it difficult to survive.
[0140] The regimen described in this application is hormonal, amino
acid and enzyme driven. By taking an overall and complete approach
to the restoring of biochemical balance, the regimen initiates
inside the cells instructions to increase the rate of biochemical
reaction. This had a positive response for the health of the
patient, and a negative outcome for the disease being combatted. By
regulating the DNA and RNA by hormonal commands, and copying the
cellular language instructions of the body earlier in the
biological life cycle, molecular, cellular and tissue enhancement,
regeneration and total improvement can be achieved. The regimen
attempts to reverse the existing cellular operational code,
providing a different direction.
* * * * *