U.S. patent application number 09/756287 was filed with the patent office on 2002-07-11 for crystal quartz insulating shell for x-ray catheter.
Invention is credited to Chornenky, Victor I., Jaafar, Ali, Kerslick, Graham S..
Application Number | 20020090053 09/756287 |
Document ID | / |
Family ID | 25042813 |
Filed Date | 2002-07-11 |
United States Patent
Application |
20020090053 |
Kind Code |
A1 |
Chornenky, Victor I. ; et
al. |
July 11, 2002 |
CRYSTAL QUARTZ INSULATING SHELL FOR X-RAY CATHETER
Abstract
An insulating housing shell for a miniature x-ray emitter is
provided. The housing shell is cut from a quartz monocrystal which
is a suitable material for the insulating housing shell due to its
resistivity and dielectric strength properties. The x-ray emitter
can be inserted into a subject's body to deliver x-ray radiation.
The emitter includes a cable, having a proximal and a distal
portion. The insulating housing shell is coupled to the distal
portion of the cable, and an anode and a cathode are disposed
within the insulating housing shell. The cathode has a granular
surface and is operative with the anode and the connector to
produce the x-ray radiation. The cathode is composed of a material
that also allows it to act as a getter.
Inventors: |
Chornenky, Victor I.; (Santa
Rosa, CA) ; Jaafar, Ali; (Eden Prairie, MN) ;
Kerslick, Graham S.; (Ithaca, NY) |
Correspondence
Address: |
Medtronic AVE, Inc.
IP Legal Department
3576 Unocal Place
Santa Rosa
CA
95403
US
|
Family ID: |
25042813 |
Appl. No.: |
09/756287 |
Filed: |
January 9, 2001 |
Current U.S.
Class: |
378/119 ;
378/122; 378/65 |
Current CPC
Class: |
A61N 5/1001 20130101;
H01J 2235/164 20130101; H01J 35/32 20130101 |
Class at
Publication: |
378/119 ;
378/122; 378/65 |
International
Class: |
A61N 005/10 |
Claims
What is claimed is:
1. A device for use in delivering x-ray radiation, comprising: a
crystalline quartz housing shell; an anode disposed within said
crystalline quartz housing shell; and a cathode disposed within
said crystalline quartz housing shell, wherein said cathode is
operative with said anode to produce the x-ray radiation.
2. The device of claim 1, wherein said crystalline quartz housing
shell is cut from a quartz monocrystal having a z-axis parallel to
the axis of said crystalline quartz housing shell.
3. The device of claim 1, wherein said cathode comprises at least
one of a granular surface and a material that allows said cathode
to act as a getter.
4. The device of claim 1, wherein said anode comprises a heavy
metal.
5. The device of claim 1, wherein said anode is composed of at
least one of gold and nickel.
6. The device of claim 1, wherein said anode is composed of
copper.
7. The device of claim 1, further comprising: a cable coupled to a
proximal end of said crystalline quartz housing shell.
8. An x-ray catheter capable of being introduced into a subject
through an introducer or trocar, comprising: a housing shell; an
anode disposed within said housing shell, and a cathode disposed
within said housing shell, wherein said housing shell is a
crystalline quartz.
9. A method for producing a device suitable for use in delivering
x-ray radiation, comprising the steps of: fabricating a structure
composed of crystalline quartz; forming a hollow chamber within the
structure; disposing a cathode within the hollow chamber, the
cathode including granular getter material; disposing an anode
within the hollow chamber, such that the anode and the cathode are
separated by a gap; and attaching an endcap, the endcap and the
anode being disposed at opposing ends of the structure to produce a
vacuum chamber from the hollow chamber, the vacuum chamber encasing
the cathode, whereby the cathode is operative with the anode to
produce the x-ray radiation.
10. The method of claim 9, wherein said fabricating step comprises
cutting crystalline quartz along a z-axis to fabricate the
structure, whereby the z-axis is parallel to the axis of the
structure.
11. The method of claim 9, further comprising the step of: mixing a
diamond powder with the granulated getter material prior to forming
the cathode for placement in the structure.
12. The method of claim 9, wherein said attaching step is performed
at temperatures below 500 degrees C. to 550 degrees C. to produce
the vacuum chamber.
Description
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] Not applicable.
STATEMENT REGARDING FEDERALLY-SPONSORED RESEARCH AND
DEVELOPMENT
[0002] Not applicable.
REFERENCE TO MICROFICHE APPENDIX/SEQUENCE LISTING/TABLE/COMPUTER
PROGRAM LISTING APPENDIX
[0003] (submitted on a compact disc and an
incorporation-by-reference of the material on the compact disc)
[0004] Not applicable.
BACKGROUND OF THE INVENTION
[0005] 1. Field of the Invention
[0006] The present invention is directed to an x-ray device having
a cold cathode. More particularly, the present invention relates to
a housing for a miniature x-ray device having a cold cathode and
method for fabrication.
[0007] 2. Background Art
[0008] Doctors and scientists continually strive to find less
invasive ways to treat patients. Using treatments that are less
intrusive to a patient's body, doctors can greatly reduce stress on
the patient's system. For example, laparoscopic techniques enable
physicians to explore the interior of the body and perform surgery
through a small opening in the skin. Less intrusive medical
techniques are extremely beneficial when applied to cardiovascular
diseases, reflux disease of the esophagus, and other diseases of
vessels, cavities and lumens of the body. To that end, catheters
and like devices have been developed to traverse the human
cardiovascular or circulatory system. Such devices have the
capability to enter small blood vessels with diameters of about two
to four millimeters, and make hairpin turns along tortuous paths
within the vasculature.
[0009] Many types of catheters have been developed to deliver
medication, such as, Heparin, Dexamethasone, and the like, to treat
cardiovascular diseases, such as, stenosis, restenosis and the
like. Catheters have also been used to provide beta-irradiation
along the wall of a blood vessel to treat illnesses such as,
restenosis. Moreover, catheters have been applied to the esophagus
to treat gastroesophageal reflux disease (GERD). Many other
disorders could be treated with small, effective medical devices
capable of accessing the interior of the body.
[0010] A typical x-ray catheter includes a coaxial cable and
miniature x-ray emitter connected to the distal end. The x-ray
emitter consists of an anode and cathode assembly mounted in a
miniature vacuum tube. To activate the x-ray catheter, a high DC or
pulse voltage (e.g., fifteen to thirty-five kilovolts (kV) range)
is applied to the tube. At the cathode surface, a high electric
field results in the electron field emission from the cathode. The
electrons are emitted into a vacuum gap between the anode and the
cathode, and are accelerated by the electric field. As the
accelerated electrons strike the anode, X-ray radiation is produced
from the electrons.
[0011] The proximal end of the coaxial cable is connected to a high
voltage power source. Outside the patient's body, the cable is
secured to a pullback device, which moves the emitter along the
blood vessel or another body cavity as it is being irradiated.
[0012] To be maneuverable within body cavities and blood vessels,
it is desirable to use as small an x-ray device as possible.
Miniaturization of x-ray emitters, however, imposes very stringent
requirements on the dielectric strength and resistivity of the
material that is required for the insulating shell. For coronary
use, the wall thickness of the emitter should be as thin as 150-200
microns, and still be able to hold about thirty kV in voltage.
This, in turn, requires the dielectric strength of the shell
material to range between 150 to 200 kV/mm.
[0013] Very few dielectric materials can satisfy these
requirements. For instance, ceramics, conventionally, have been
used for insulation because they are relatively inexpensive, but
they are ineffective for high voltage applications. Boron nitride
is another conventional insulating material. However, boron nitride
has poor vacuum integrity. Boron nitride is also a soft,
mechanically weak material that is prone to cracking at the brazing
joints. By using a long and sophisticated chemical vapor deposition
(CVD) process, diamonds can be grown in special chambers to meet
the resistivity and dielectric strength requirements. Although CVD
diamonds have low thermal expansion properties, CVD diamonds have
low absorption of x-ray and are not very accessible or machinable
due to the CVD process.
[0014] What is needed, therefore, is an insulating material for the
housing of an x-ray emitter that reduces cracking, and is easy and
inexpensive to produce.
BRIEF SUMMARY OF THE INVENTION
[0015] The present invention is directed to an insulating housing
shell used to encase a miniature x-ray emitter. In a preferred
embodiment, the housing shell is cut from a quartz monocrystal
along its z-axis.
[0016] The x-ray emitter is suitable for inserting into a subject's
body and delivering x-ray radiation. The emitter includes a coaxial
cable, having a proximal and a distal portion. The distal portion
of the cable is coupled to the crystalline quartz housing shell.
The housing shell provides a vacuum chamber enclosing an anode and
a cathode disposed therein. The cathode has a granular surface and
is operative with the anode and the cable to produce the x-ray
radiation. The cathode is composed of a material that also allows
it to act as a getter. The cathode can also include a diamond film
on its surface that facilitates cold electron emission.
[0017] An advantage of the present invention is that crystalline
quartz housing is compatible with existing brazing, soldering or
other bonding technologies. This permits the vacuum chamber to be
easily fabricated by known or future developed brazing, soldering
or other bonding techniques.
[0018] Another advantage of the present invention is that the
resistivity and dielectric strength properties of crystalline
quartz do not substantially degrade or crack at higher
temperatures.
[0019] Another advantage of the present invention is that
crystalline quartz is easily accessible and machinable.
BRIEF DESCRIPTION OF THE DRAWINGS/FIGURES
[0020] The accompanying drawings, which are incorporated herein and
form part of the specification, illustrate the present invention
and, together with the description, further serve to explain the
principles of the invention and to enable a person skilled in the
pertinent art to make and use the invention. In the drawings, like
reference numbers indicate identical or functionally similar
elements. Additionally, the leftmost digit(s) of a reference number
identifies the drawing in which the reference number first
appears.
[0021] FIG. 1 illustrates a cross-sectional view, taken along a
line 1-1 of FIG. IA, of an x-ray emitter according to an embodiment
of the present invention.
[0022] FIG. 1A illustrates a perspective view of the x-ray emitter
of FIG. 1.
[0023] FIG. 2 illustrates an insulating housing shell according to
an embodiment of the present invention.
DETAILED DESCRIPTION OF THE INVENTION
[0024] The present invention is directed to an insulating housing
shell for a device, and method of fabrication thereof, that
irradiates passages, lumens, vessels, cavities, or interior sites
in a subject's body with x-ray radiation. The device of the present
invention is particularly advantageous in treating restenosis and
stenosis of the cardiovascular vessels, gastroesophageal and
gastrointestinal systems, and other ailments where delivery of
localized x-ray radiation to interior portions of the body has been
discovered to be effective. In an embodiment, the x-ray device can
be introduced into the subject through an introducer or trocar.
[0025] Many disease states of the body involve the abnormal
thickening of a lumen or passage. The x-ray device of the present
invention provides a very promising way to treat these types of
conditions. The x-ray device produces ionizing radiation that
penetrates controllable depths of the cells on the surface of the
passage or lumen. This radiation induces apoptosis, or programmed
cell death.
[0026] X-ray radiation has been found to reduce the occurrence of
restenosis when x-ray radiation is applied to area of a blood
vessel where an angioplasty or other expansion of the vessel has
taken place. In coronary applications, it is desirable to have the
x-ray radiation penetrate into the adventitia tissue of the blood
vessels about 0.5 to 1.0 mm in depth. Penetration into the cardiac
muscle tissue should be minimized.
[0027] In one aspect of the present invention, an x-ray device
positioned in the esophagus is used to treat Barrett's esophagus by
inducing apoptosis in the abnormal cells of the epithelium. The use
of the x-ray device of the present invention can therefore be used
to reduce the escalation of this condition to cancer. Further, the
x-ray device of the present invention can be used for preventing
the thickening of the pylorus after dilatation of pyloric
strictures.
[0028] When treating the interior of the body, it is desirable to
use as small a device as possible. Very small devices are required
when traversing the blood vessels of the cardiovascular system, for
example. A smaller device will be more easily guided to the site of
treatment. It is also important to minimize the occlusion of the
blood vessel, in order to allow blood flow to the greatest extent
possible.
[0029] FIG. 1 and FIG. 1A illustrate an x-ray emitter 100 according
to an embodiment of the present invention. X-ray emitter 100 has a
proximal end 102 and a distal end 104, and includes a cathode 112,
an anode 114, an endcap 116, and a housing shell 118. Anode 114,
endcap 116, and housing shell 118 define a vacuum chamber which
encloses a vacuum space 124. In order to produce x-ray radiation,
an electrical field is applied across cathode 112 and anode 114,
resulting in the emission of electrons from cathode 112 and
acceleration of these electrons toward anode 114. Anode 114
consists of a heavy metal that causes the electrons to consistently
produce x-ray radiation when the high-speed electrons are incident
upon anode 114.
[0030] The x-ray radiation is emitted and travels through housing
shell 118 which is moderately transparent to x-rays. The x-ray
radiation is low energy below eight kiloelectron volts (keV), and
must be filtered to avoid overly radiating the surface of the blood
vessel. Housing shell 118 (described in detail below) performs this
function. Anode 114 and cathode 112 are separated by a gap that
varies depending on the requirements of the particular application.
For many coronary applications, the gap can range from 0.20 to 1.5
mm. It would be apparent to one skilled in the relevant art(s) that
gaps within a variety of ranges can be used depending on the
particular application.
[0031] X-ray emitter 100 can be supplied with a high voltage by a
cable 126, such as a coaxial cable and the like. Proximal end 102
of x-ray emitter 100 can be coupled to cable 126, such that the
distal end of cable 126 is disposed within the body during
treatment. A proximal end of cable 126 emerges from the body and
can be coupled to a voltage generator (not shown).
[0032] It is desirable to maintain a vacuum condition within
housing shell 118. In order to create the vacuum chamber,
frequently, the components are assembled within a vacuum or the
chamber is evacuated by conventional methods to create a vacuum.
Further, a getter can also be disposed within housing shell 118.
The getter can include zirconium, aluminum, vanadium, iron, and/or
titanium. In an embodiment, the getter materials can be composed of
an alloy including vanadium, iron and zirconium. One successful
choice for the getter is a material produced by SAES and referred
to as ST707. The SAES ST707 alloy getter is produced by thermal
diffusion bonding and is composed of 24.6% vanadium, 5.4% iron, and
70% zirconium.
[0033] The getter has an activation temperature at which it will
react with stray gas molecules in a vacuum. For example, the SAES
ST707 alloy getter has an activation temperature of 400-500 degrees
Celsius (C.). Before the getter is activated, it is covered with a
layer of oxidation that shields the getter material from the
atmosphere at normal conditions. When the getter is heated to its
activation temperature in a vacuum, the oxidation layer diffuses
into the interior of the getter, revealing the active getter
surface, which will react and bond with any stray gas molecule. The
getter, therefore, eliminates stray gas molecules, thereby
improving the quality of the vacuum within housing shell 118 up to
10.sup.-7 to 10.sup.-8 Torr.
[0034] It can be shown that a getter serves as an electron emitter
when a voltage differential is applied. Therefore, in an
embodiment, the getter is used as cathode 112. This combination of
elements results in a smaller x-ray device with a very simple
design. Accordingly, the getter must be sufficiently conductive and
capable of electron emission to serve as an effective cathode at
moderate electrical fields, for example, ten volts per micron to
sixty volts per micron.
[0035] As described, a getter cathode 112 can be composed of many
different types of getter materials. In an embodiment, cathode 112
consists of granular getter materials. The granulated surface of
cathode 112 provides multiple microprotrusions capable of efficient
field emission of electrons at moderate electrical fields. Using
granular getter materials, field emission current densities of
approximately 0.5 to 5 milliamps per square millimeter are observed
at cathode 112 at electrical fields of ten to fifty volts per
micron. This level of emission current is similar to that found in
diamond-coated cathodes at electrical fields that are moderate for
x-ray production. Therefore, when cathode 112 is made of granular
metal materials, cathode 112 typically does not require an
additional coating, such as a diamond film, in order to emit
electrons at moderate electrical fields for x-ray applications.
Moreover, a device using a granular getter material as cathode 112
is considerably less complicated to manufacture. Cathode 112 with
microprotrusions can be formed by thermal diffusion bonding of
granulated getter material, or getter powder, having granular sizes
of 0.5 to 50 micrometers in diameter.
[0036] In an embodiment of the present invention, x-ray radiation
is produced while keeping the required electrical fields low by
mixing titanium carbide or, preferably, a diamond powder with the
granulated getter materials before forming cathode 112. Diamond
materials display valuable properties as field emitters, losing
electrons easily as a field is applied. Where a diamond powder is
included in cathode 112, an electrical field of ten to fifty volts
per micron will produce current densities in the range of one to
ten milliamps per millimeter square. The diamond material can be
purchased commercially from numerous sources. Most of the powder
diamond material is obtained from laser deposition that can be
performed at room temperature, although it can be produced from
natural beds of diamond.
[0037] In an embodiment of the present invention, the field
emission properties of cathode 112 can be modified by a
conditioning procedure that alters the surface of cathode 112 to
achieve predetermined field emission parameters. Multiple
applications of high voltage are carried out at different distances
and relative positions of the electrodes, causing electrical
discharges between electrodes. The discharges destroy unstable
emitting sites at cathode 112 surface and drive the field emission
parameters into the desired range. As a result, a conditioned
cathode 112 is capable of more efficient and consistent
performance. Conditioning of cathode 112 can be carried out
according to the concepts set forth in High Voltage Vacuum
Insulation: Basic Concepts and Technological Practice, R. V.
Latham, Editor, Academic Press, 1995.
[0038] Spark conditioning and current conditioning can be used to
improve cathode 112 in an embodiment of the present invention. The
slow application of voltage involved in current conditioning can be
the most preferable method for conditioning cathode 112. Current
conditioning involves slow increases in the application of voltage
across cathode 112 and anode 114. Voltage application can begin at
about one kilovolt per millimeter and gradually increase to about
sixty kilovolts per millimeter, and perhaps as high as 100
kilovolts per millimeter. The voltage application can increase in
increments of one kilovolt per millimeter in an embodiment of the
present invention. The procedure for conditioning cathode 112 can
take about thirty minutes. The conditioning process can be carried
out before cathode 112 is assembled with the housing.
[0039] The slow application of increasing voltage gradually melts
the microprotrusions present on cathode 112. The sharpest
field-emitting microprotrusions can be thermally blunted following
excessive electron emission brought on by the current
conditioning.
[0040] While attempting to produce x-ray radiation of about eight
to ten keV in the body, it is important to keep the magnitude of
the electrical fields at the surface of cathode 112 low enough to
prevent arcing between anode 114 and cathode 112. Just on the other
side of housing shell 118 from anode 114 and cathode 112, a
conductive layer 119 is held at ground. An electrical discharge
from the surface of cathode 112 to anode 114 along the inside
surface of housing shell 118 is termed an electric flashover. An
electric flashover must be prevented to keep x-ray emitter 100
operative. According to the present invention, the probability of
flashover is reduced by configuring cathode 112 and endcap 116 to
be shielded at the point at which they meet. Moreover,
diamond-coated field electron emissions start at a lower electrical
field. Therefore, the emissions are more stable.
[0041] Due to concerns about bulk breakdown attributed to vacuum
and material breakdown and flashover, dielectric strength is an
important consideration for choosing a material for housing shell
118. The dielectric strength is the maximum electric field that a
material can withstand before breaking down. However, surface
discharge can occur at lower electrical field strengths. Many
individual factors affect the flashover voltage, such as the
surface geometry, material contamination, the material history, and
vacuum quality.
[0042] The ability to lower the required electric field at cathode
112 results in a less expensive manufacturing technique. Small
irregularities on the surface of cathode 112 result in an increase
in the magnitude of the electrical field for an applied voltage,
thereby increasing the chance of electrical flashover. The weaker
the required electrical field at cathode 112, the more
imperfections can be tolerated on cathode 112 surface without
risking vacuum breakdown from unstable emission sites.
[0043] Heat is generated by the operation of x-ray emitter 100.
Therefore, it is important that the coefficients of thermal
expansion (CTEs) are similar in all materials used to construct
x-ray emitter 100. If materials having inconsistent CTEs are used,
the integrity of the vacuum chamber of x-ray emitter 100 can be
jeopardized. In an embodiment of the present invention, endcap 116
is composed of molybdenum, having a coefficient of thermal
expansion (CTE) of 4.9.times.10.sup.-6 per degrees C. However as
intimated above, endcap 116 can be composed of any material having
a CTE that is consistent with the CTE of housing shell 118 to
preserve the vacuum seal. The CTE of anode 114 is also important
because it seals proximal end 102 of housing shell 118. Therefore,
in an embodiment, anode 114 can be comprised of tungsten, having a
CTE of 4.6.times.10.sup.-6 per degrees C. Other materials and
combinations of materials having similar properties and comparable
coefficients of thermal expansion could be used.
[0044] Another consequence of heat generation is that cooling can
be desirable in some situations. Where x-ray emitter 100 is used in
a blood vessel, the blood flow past x-ray emitter 100 is sufficient
to dissipate the generated heat. Where the x-ray emitter 100 is
used in the esophagus or other cavity, a fluid could circulate
through a balloon surrounding x-ray emitter 100 to prevent damage
to the body.
[0045] In an embodiment, the elements of x-ray emitter 100 are
bonded together using vacuum brazing. A brazing alloy joins cathode
112 to endcap 116. Further a brazing alloy connects endcap 116 to
housing shell 118. Additional brazing alloy bonds anode 114 to
housing shell 118. The vacuum brazing techniques are important to
maintaining the integrity of the vacuum chamber. Vacuum brazing as
used in x-ray emitter 100 can be provided by Koral Labs,
Minneapolis, Minn., for example. Two examples of preferred brazing
alloys are AuSn and AuGe. While this embodiment describes a
preferred method for bonding the elements, it should be understood
that any presently available or future developed bonding technique
or methodology, including, but not limited to, soldering, welding,
epoxy, other adhesives and the like, can be used to attach the
elements or seal housing shell 118.
[0046] The shape of cathode 112 affects the electron emission
qualities of cathode 112. Cathode 112 can be cylindrically shaped
with a half full sphere shape on one end. Alternatively, cathode
112 can have a standard 118 degree drill point at the tip of one
end.
[0047] In order to apply an electric field across anode 114 and
cathode 112, a coaxial cable can be used as cable 126. The coaxial
cable 126 can be coupled to a high-voltage generator at a proximal
end of cable 126 that remains outside the body. The distal end of
coaxial cable 126 can be coupled to x-ray emitter 100. An internal
conductor of coaxial cable 126 can be coupled to anode 114 at the
appropriate voltage. An external conductive layer of coaxial cable
126 can be held at ground and coupled to cathode 112 base via a
conductive solder. Other methods can also be used to apply the
electric field across anode 114 and cathode 112 as would be
apparent to one skilled in the relevant art(s).
[0048] Coaxial cable 126 used in conjunction with the present
invention must be able to carry the required voltages, have
sufficient flexibility to make sharp turns as it follows the path
of an interior passage of the body, and have a sufficiently small
diameter to traverse the area of the body to be treated. Standard
high voltage coaxial cables are generally not flexible enough.
However, miniature high frequency coaxial cables with an outer
diameter of approximately one millimeter to three millimeters
generally exhibit sufficient flexibility. These types of cables are
typically used in high frequency applications at voltages less than
several kilovolts. Such cables have been discovered to hold direct
current voltages as high as 75-100 kV without breakdown. Therefore,
these cables are well suited for use with x-ray emitter 100. In an
embodiment, a cable with an outer diameter less than or equal to
three millimeters is used as cable 126. In another embodiment,
cable 126 has an outer diameter of one to two millimeters. Such
cables are manufactured by, for example, New England Electric Wire
Corporation, Lisborn, N.H.
[0049] Housing shell 118 of x-ray emitter 100 is substantially
transparent to x-rays in order to allow a fall dosage to reach a
treatment site. Housing shell 118 is an electrical insulator,
capable of supporting x-ray emitter 100 without electrical
discharge between the exterior of housing shell 118 at ground and
the interior of housing shell 118 at high voltage. A biocompatible
coating of a polymeric material, such as, polyethylene,
polyurethane or Teflon.RTM., for example is applied to the external
surfaces of housing shell 118. Housing shell 118 can be composed of
CVD boron nitride, CVD silicon nitride, beryllium oxide, aluminum
oxide, or other such metals or ceramic material. Housing shell 118
can also be composed of a CVD diamond three-dimensional structure.
However, as discussed, these materials have several drawbacks,
namely they lack the requisite dielectric strength or are too
expensive to manufacture, for high voltage applications.
[0050] In a preferred embodiment, crystalline quartz is used to
fabricate housing shell 118. Crystalline quartz refers to natural
or man-made SiO.sub.2 in crystalline form (also known as
monocrystal quartz). Crystalline quartz has a dielectric strength
of about 600 kV/mm that does not drop as temperature increases. As
described above for coronary applications, the thickness of housing
shell 118 should be as thin as 150-200 microns, and capable of
holding about thirty kV in voltage with a dielectric strength
ranging between 150 to 200 kV/mm. It can be shown that the
dielectric strength of 200 microns thick crystalline quartz plates
is higher than 175 kV/mm, which meets the dielectric strength
requirements.
[0051] The resistivity for crystalline quartz is 10.sup.16 ohms-cm.
In comparison to CVD diamonds, crystalline quartz has a higher
absorption of x-ray, but is more inexpensive, accessible and
machinable than a diamond-based insulating shell.
[0052] A method for producing a device suitable for insertion into
a body and delivering x-ray radiation is also contemplated by the
present invention. First, housing shell 118 is machined or cut from
crystalline quartz using conventional techniques. FIG. 2
illustrates housing shell 118 cut from crystalline quartz according
to an embodiment of the present invention. As shown, housing shell
118 is cut from the crystalline quartz with the z-axis parallel to
the axis of housing shell 118. A z-cut is a preferred cut to ensure
housing shell 118 satisfies the dielectric strength and resistivity
requirements. At a temperature ranging from room temperature to 550
degrees C., crystalline quartz has a CTE of 12.times.10.sup.-6 per
degrees C. along the direction parallel to z-axis. In the direction
perpendicular to the z-axis, the CTE is 20.times.10.sup.-6per
degrees C.
[0053] After housing shell 118 has been cut to the desired length,
cathode cavity 212 and anode cavity 214 are formed, using
conventional techniques. Next, a structure for cathode 112,
including molded granular getter material, and anode 114 are
provided. This method of manufacture provides the advantage of
simplicity because cathode 112 and getter components are present in
the same structure. Cathode 112 and anode 114 are then enclosed in
a vacuum housing so that cathode 112 is operative with anode 114 to
produce x-ray radiation. All vacuum sealing procedures are
recommended to be performed at temperatures below 500 degrees C. to
550 degrees C. Typically, crystalline quartz incurs a phase
transition at 575 degrees C. with a significant volume change,
which can cause cracking of the crystal under thermal stresses.
[0054] In an embodiment, to seal quartz-based x-ray emitter 100,
the brazing surfaces of housing shell 118 at the conical surface of
anode 114 and the surface endcap 116 are preliminary metallized by
using techniques known to those skilled in the relevant art(s).
Next, a 450 degrees C. to 550 degrees C. brazing process is applied
for the final sealing of x-ray emitter 100. Thus, crystalline
quartz is compatible with existing brazing and like bonding
technologies.
[0055] As described above, the CTEs of the other components of
x-ray emitter 100 should be consistent with the CTE of quartz-based
housing shell 118 to maintain the integrity of the vacuum chamber
of x-ray emitter 100. Therefore, the CTE for the material used to
compose endcap 116 can range from 5.times.10.sup.-6 per degrees C.
to 13.times.10.sup.-6 per degrees C. In an embodiment, gold having
a CTE of 14.2.times.10.sup.-6 per degrees C. is used as the
material for anode 114. In another embodiment, copper having a CTE
of 16.6.times.10.sup.-6 per degrees C. is used as the material for
anode 114. In another embodiment, nickel having a CTE of
13.times.10.sup.-6 per degrees C. is used as the material for anode
114. The nickel can be coated with gold to produce a heavier metal
and increase the efficiency of the radiation.
[0056] While various embodiments of the present invention have been
described above, it should be understood that they have been
presented by way of example, and not limitation. It will be
apparent to persons skilled in the relevant art(s) that various
changes in form and detail can be made therein without departing
from the spirit and scope of the invention. Thus, the present
invention should not be limited by any of the above described
exemplary embodiments, but should be defined only in accordance
with the following claims and their equivalents.
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