U.S. patent application number 09/908915 was filed with the patent office on 2002-05-30 for inhalator, a powder composition and a process for administering the powder composition using inhalators.
This patent application is currently assigned to UNISIA JECS CORPORATION. Invention is credited to Ishizeki, Kazunori, Nakamura, Shigemi, Ohki, Hisatomo, Yazawa, Yoshiyuki, Yokobori, Mitsuru.
Application Number | 20020062829 09/908915 |
Document ID | / |
Family ID | 26604636 |
Filed Date | 2002-05-30 |
United States Patent
Application |
20020062829 |
Kind Code |
A1 |
Ohki, Hisatomo ; et
al. |
May 30, 2002 |
Inhalator, a powder composition and a process for administering the
powder composition using inhalators
Abstract
An inhalator including an inhalator body including a powder
receiving chamber for receiving a powder, an air-powder mixture
reservoir for temporarily storing an air-powder mixture flowing
from the powder receiving chamber, and a diluent air passage for
introducing a diluent air into the air-powder mixture reservoir.
The air-powder mixture is formed within the powder receiving
chamber when an air is introduced into the powder receiving
chamber. The air-powder mixture within the air-powder mixture
reservoir is admixed with a diluent air introduced thereinto
through the diluent air passage. The diluted air-powder mixture is
discharged from an air-powder mixture outlet into a user's oral or
nasal cavity. A powder composition for inhalators includes at least
two kinds of fine particles different in particle diameter.
Inventors: |
Ohki, Hisatomo; (Gunma,
JP) ; Yazawa, Yoshiyuki; (Gunma, JP) ;
Nakamura, Shigemi; (Gunma, JP) ; Yokobori,
Mitsuru; (Gunma, JP) ; Ishizeki, Kazunori;
(Gunma, JP) |
Correspondence
Address: |
FOLEY & LARDNER
Washington Harbour
Suite 500
3000 K Street, N.W.
Washington
DC
20007-5109
US
|
Assignee: |
UNISIA JECS CORPORATION
|
Family ID: |
26604636 |
Appl. No.: |
09/908915 |
Filed: |
July 20, 2001 |
Current U.S.
Class: |
128/203.15 ;
128/203.12; 128/203.21; 604/58 |
Current CPC
Class: |
A61M 15/003 20140204;
A61M 11/001 20140204; A61M 15/0033 20140204; A61M 2206/16 20130101;
A61M 2202/064 20130101; A61M 15/0028 20130101 |
Class at
Publication: |
128/203.15 ;
128/203.21; 128/203.12; 604/58 |
International
Class: |
A61M 013/00; A61M
015/00; A61M 016/10; B05D 007/14; A61M 016/00; B65D 083/06 |
Foreign Application Data
Date |
Code |
Application Number |
Nov 29, 2000 |
JP |
2000-363636 |
Nov 27, 2000 |
JP |
2000-359822 |
Claims
What is claimed is:
1. An inhalator for administering an air-powder mixture,
comprising: an inhalator body including an air intake path for
introducing an air into the inhalator body, and an air-powder
mixture outlet for discharging the air-powder mixture from the
inhalator body; a powder receiving chamber adapted to receive a
powder, the powder receiving chamber being disposed within the
inhalator body and communicated with an outside of the inhalator
body through the air intake path; an air-powder mixture path
adapted to transmit the air-powder mixture flowing from the powder
receiving chamber to the air-powder mixture outlet; an air-powder
mixture reservoir adapted to temporarily store the air-powder
mixture flowing from the powder receiving chamber, the air-powder
mixture reservoir being disposed within the air-powder mixture
path; and a diluent air passage adapted to introduce a diluent air
into the air-powder mixture reservoir, the diluent air passage
communicating the air-powder mixture reservoir with the outside of
the inhalator body.
2. The inhalator as claimed in claim 1, further comprising a second
diluent air passage adapted to introduce a diluent air into the
air-powder mixture path downstream of the air-powder mixture
reservoir upon the air-powder mixture flowing from the air-powder
mixture reservoir, and a regulator variably controlling an opening
area of the second diluent air passage.
3. The inhalator as claimed in claim 1, further comprising a
dispersion part adapted to disperse the powder in the air-powder
mixture passing through the air-powder mixture path downstream of
the air-powder mixture reservoir.
4. The inhalator as claimed in claim 3, wherein the dispersion part
comprises a plurality of dispersion passages branched from the
air-powder mixture path downstream of the air-powder mixture
reservoir, and a dispersion chamber disposed within the air-powder
mixture path downstream of the dispersion passages, each of the
dispersion passages having an outlet passage portion that is open
into the dispersion chamber and arranged to form a swirl flow of
the air-powder mixture.
5. The inhalator as claimed in claim 4, wherein the dispersion
chamber has a generally circular-shaped section and the outlet
passage portion of each of the dispersion passages extends in a
tangential direction of the dispersion chamber.
6. The inhalator as claimed in claim 1, wherein the air intake path
is arranged to allow and block fluid communication between the
powder receiving chamber and the outside of the inhalator body.
7. The inhalator as claimed in claim 6, wherein the air intake path
comprises at least two passages having an alignment position where
the at least two passages are in alignment with each other and an
offset position where the at least two passages are out of
alignment with each other.
8. The inhalator as claimed in claim 1, wherein the air-powder
mixture path is arranged to allow and block fluid communication
between the powder receiving chamber and the air-powder mixture
reservoir.
9. The inhalator as claimed in claim 8, wherein the air-powder
mixture path comprises at least two passages disposed between the
powder receiving chamber and the air-powder mixture reservoir, the
plurality of passages having an alignment position where the at
least two passages are aligned with each other and an offset
position where the at least two passages are offset from each
other.
10. The inhalator as claimed in claim 4, further comprising a
second air-powder mixture adapted to temporarily store the
air-powder mixture flowing from the first air-powder mixture
reservoir toward the dispersion passages of the dispersion
part.
11. The inhalator as claimed in claim 10, wherein each of the
dispersion passages comprises an inlet open into the second
air-powder mixture reservoir.
12. An inhalator for administering an air-powder mixture,
comprising: a casing including an air intake inlet for introducing
an air into the casing, and an air-powder mixture outlet for
discharging the air-powder mixture from the casing; powder
receiving means for receiving a powder within the casing and
permitting the powder to be admixed with the air introduced from
the air intake inlet; air-powder mixture storing means for
temporarily storing the air-powder mixture passing through the
powder receiving means; diluent air passage means for permitting a
diluent air to flow into the air-powder mixture storing means; and
air-powder mixture path means for permitting the air-powder mixture
to flow from the powder receiving means to the air-powder mixture
outlet via the air-powder mixture storing means.
13. The inhalator as claimed in claim 12, further comprising air
intake path means for permitting the air to flow from the air
intake inlet into the powder receiving means.
14. The inhalator as claimed in claim 12, wherein the air-powder
mixture path means allows and blocks fluid communication between
the powder receiving means and the air-powder mixture storing
means.
15. The inhalator as claimed in claim 12, further comprising a
second diluent air passage means for permitting a diluent air to
flow into the air-powder mixture path means downstream of the
air-powder mixture storing means upon the air-powder mixture
flowing from the air-powder mixture storing means.
16. The inhalator as claimed in claim 15, further comprising a
regulator variably controlling an opening area of the second
diluent air passage means.
17. The inhalator as claimed in claim 12, further comprising
dispersion means for preventing the powder in the air-powder
mixture from being aggregated together.
18. The inhalator as claimed in claim 17, wherein the dispersion
means comprises passages means for forming a swirl flow of the
air-powder mixture and chamber means for receiving the swirl flow
of the air-powder mixture.
19. The inhalator as claimed in claim 18, wherein the chamber means
has a generally circular-shaped section and the passage means
extends in a tangential direction of the chamber means.
20. A powder composition for use with an inhalator, comprising: at
least two kinds of fine particles selected from a first kind of
fine particles having an aerodynamic mean particle diameter of not
less than 7 .mu.m, a second kind of fine particles having an
aerodynamic mean particle diameter of 5-7 .mu.m, a third kind of
fine particles having an aerodynamic mean particle diameter of 3-5
.mu.m, a fourth kind of fine particles having an aerodynamic mean
particle diameter of 1-3 .mu.m, and a fifth kind of fine particles
having an aerodynamic mean particle diameter of not more than 1
.mu.m.
21. The powder composition as claimed in claim 20, wherein the
powder composition comprises powder tobacco.
22. The powder composition as claimed in claim 20, wherein the
powder composition comprises particulate medicament.
23. A process for administering a powder composition using an
inhalator, comprising: preparing the powder composition containing
at least two kinds of fine particles selected from a first kind of
fine particles having an aerodynamic mean particle diameter of not
less than 7 .mu.m, a second kind of fine particles having an
aerodynamic mean particle diameter of 5-7 .mu.m, a third kind of
fine particles having an aerodynamic mean particle diameter of 3-5
.mu.m, a fourth kind of fine particles having an aerodynamic mean
particle diameter of 1-3 .mu.m, and a fifth kind of fine particles
having an aerodynamic mean particle diameter of not more than 1
.mu.m; supplying the powder composition to the inhalator; and
discharging the powder composition from the inhalator.
24. The process as claimed in claim 23, wherein the discharging
comprises dispersing the powder composition within the
inhalator.
25. The process as claimed in claim 23, further comprising
capsulating the powder composition.
26. The process as claimed in claim 23, wherein the powder
composition comprises powder tobacco.
27. The process as claimed in claim 23, wherein the powder
composition comprises particulate medicament.
Description
BACKGROUND OF THE INVENTION
[0001] The present invention relates to an inhalator suitable for
administering a powder or powder composition, and a powder
composition containing powders different in particle diameter from
each other and a process for administering the powder composition
using inhalators.
[0002] Generally, a powder inhalator is used for inhaling a powder
or powder composition such as a powdered medicine into a human body
through the oral or nasal cavity. The inhalator includes an
inhalator body having an air intake path for introducing an ambient
air and a suction opening through which an air-powder mixture
within the inhalator body is sucked into the oral or nasal cavity.
A powder receiving chamber for receiving the powder is disposed
within the inhalator body and communicated with the outside of the
inhalator body via the air intake path. An air-powder mixture path
extends from the powder receiving chamber to the suction opening.
The air-powder mixture is formed when the air is introduced into
the powder receiving chamber through the air intake path. The
air-powder mixture is then transmitted from the powder receiving
chamber to the suction opening via the air-powder mixture path.
[0003] There are several types of powders different in aerodynamic
mean particle diameter as follows: a powder having the aerodynamic
mean particle diameter of not less than 7 .mu.m and depositing in
an oral cavity or hypoglottis, a powder having the aerodynamic mean
particle diameter of 5-7 .mu.m and depositing in a throat, a powder
having the aerodynamic mean particle diameter of 3-3 .mu.m and
depositing in a trachea, a powder having the aerodynamic mean
particle diameter of 1-3 .mu.m and depositing in bronchi, and a
powder having the aerodynamic mean particle diameter of not more
than 1 .mu.m and depositing into alveoli, and the like. The powder
having the aerodynamic mean particle diameter of not more than 3
.mu.m is required to surely reach affected areas of the human body.
Also, the powder such as an acrid powder is preferably dosed in
several parts upon being inhaled.
[0004] In addition, there has been proposed powder tobacco for use
with the inhalator. The powder tobacco can be substituted for a
usual smoking tobacco because the powder tobacco provides a smoking
feeling upon being inhaled. When the powder tobacco is used, one
dose of the powder tobacco is dispensed in parts from the inhalator
upon each inhalation.
[0005] The human bronchi and alveoli exist in deeper portions of
the human body. Therefore, in order to ensure stable deposit of the
powder having the particle diameter of not more than 3 .mu.m in the
bronchi and alveoli, it is preferable to dose the powder in parts,
i.e., dispense a small amount of the powder each inhalation.
[0006] However, in the earlier technique, the whole amount of the
powder received within the powder receiving chamber of the
inhalator is dispensed from the inhalator by the inhalation
substantially at one time. If a dose of the powder having the
particle diameter of not more than 3 .mu.m is inhaled through the
inhalator upon inhalation, a large amount of the powder dosed will
be deposited in the oral cavity or trachea before being deposited
in the bronchi and alveoli.
[0007] Further, there is known a process for administering a
particulate medicament having a specific mean particle diameter
into a patient's lungs upon the patient breathing. International
Publication No. WO97/36574 discloses a process and device for
inhalation of particulate medicament. The process includes (i)
providing an inhalator which contains at least one dose of
medicament particles comprising spherical hollow particulates of
respirable particle size suitable for deposition in a human lungs,
and (ii) removing the spherical hollow particulates from the
inhalator. In the earlier technique, the particulate medicament
having the specific particle diameter is used with the inhalator,
but there is not described inhalation on multi-purpose
prescription, for instance, one-time inhalation of multiple
particulate medicaments for the purpose of simultaneous deposition
in different portions such as the trachea and the alveoli of the
patient's body. In order to follow the multi-purpose prescription,
it is required that the patient repeatedly inhales separate doses
of particulate medicaments for different prescriptions, takes a
specific particulate medicament formulated for the multi-purpose
prescription, or is treated with the combination of various
prescriptions including peroral medicament, injection, application
of fomentation, and the like.
SUMMARY OF THE INVENTION
[0008] It is an object of the present invention to provide an
inhalator capable of dispensing one dose of a powder or powder
composition in parts therefrom.
[0009] It is another object of the present invention to provide a
powder composition containing powders different in particle
diameter from each other and a process for administering the powder
composition using inhalators, which are suitable for simultaneous
deposition in different portions of the human body by one-time
inhalation.
[0010] According to one aspect of the present invention, there is
provided an inhalator for administering an air-powder mixture,
comprising:
[0011] an inhalator body including an air intake path for
introducing air into the inhalator body, and an air-powder mixture
outlet for discharging the air-powder mixture from the inhalator
body;
[0012] a powder receiving chamber adapted to receive a powder, the
powder receiving chamber being disposed within the inhalator body
and communicated with an outside of the inhalator body through the
air intake path;
[0013] an air-powder mixture path adapted to transmit the
air-powder mixture flowing from the powder receiving chamber to the
air-powder mixture outlet;
[0014] an air-powder mixture reservoir adapted to temporarily store
the air-powder mixture flowing from the powder receiving chamber,
the air-powder mixture reservoir being disposed within the
air-powder mixture path; and
[0015] a diluent air passage adapted to introduce a diluent air
into the air-powder mixture reservoir, the diluent air passage
communicating the air-powder mixture reservoir with the outside of
the inhalator body.
[0016] According to a further aspect of the present invention,
there is provided an inhalator for administering an air-powder
mixture, comprising:
[0017] a casing including an air intake inlet for introducing air
into the casing, and an air-powder mixture outlet for discharging
the air-powder mixture from the casing;
[0018] powder receiving means for receiving a powder within the
casing and permitting the powder to be admixed with the air
introduced from the air intake inlet;
[0019] air-powder mixture storing means for temporarily storing the
air-powder mixture passing through the powder receiving means;
[0020] diluent air passage means for permitting a diluent air to
flow into the air-powder mixture storing means; and
[0021] air-powder mixture path means for permitting the air-powder
mixture to flow from the powder receiving means to the air-powder
mixture outlet via the air-powder mixture storing means.
[0022] According to another aspect of the present invention, there
is provided a powder composition for use with an inhalator,
comprising:
[0023] at least two kinds of fine particles selected from a first
kind of fine particles having an aerodynamic mean particle diameter
of not less than 7 .mu.m, a second kind of fine particles having an
aerodynamic mean particle diameter of 5-7 .mu.m, a third kind of
fine particles having an aerodynamic mean particle diameter of 3-3
.mu.m, a fourth kind of fine particles having an aerodynamic mean
particle diameter of 1-3 .mu.m, and a fifth kind of fine particles
having an aerodynamic mean particle diameter of not more than 1
.mu.m.
[0024] According to a further aspect of the present invention,
there is provided a process for administering a powder composition
using an inhalator, comprising:
[0025] preparing the powder composition containing at least two
kinds of fine particles selected from a first kind of fine
particles having an aerodynamic mean particle diameter of not less
than 7 .mu.m, a second kind of fine particles having an aerodynamic
mean particle diameter of 5-7 .mu.m, a third kind of fine particles
having an aerodynamic mean particle diameter of 3-3 .mu.m, a fourth
kind of fine particles having an aerodynamic mean particle diameter
of 1-3 .mu.m, and a fifth kind of fine particles having an
aerodynamic mean particle diameter of not more than 1 .mu.m;
[0026] supplying the powder composition to the inhalator; and
[0027] discharging the powder composition from the inhalator.
[0028] The other objects and features of this invention will become
understood from the following description with reference to the
accompanying drawings.
BRIEF DESCRIPTION OF THE DRAWINGS
[0029] FIG. 1 is an elevation of an inhalator of a preferred
embodiment, according to the present invention;
[0030] FIG. 2 is a longitudinal section of the inhalator, taken
along the line 2-2 of FIG. 1, showing a rest position of the
inhalator;
[0031] FIG. 3 is an enlarged section of the inhalator, taken along
the line 3-3 of FIG. 2;
[0032] FIG. 4 is an enlarged section of the inhalator, taken along
the line 4-4 of FIG. 2;
[0033] FIG. 5 is an enlarged section of the inhalator, taken along
the line 5-5 of FIG. 2; and
[0034] FIG. 6 is a view similar to FIG. 2, but showing a use
position of the inhalator.
DETAILED DESCRIPTION OF THE INVENTION
[0035] Referring to FIGS. 1-6, an inhalator, according to the
present invention, of a preferred embodiment is explained.
[0036] As illustrated in FIG. 1, the inhalator includes an
inhalator body 1 as a casing which is formed into a cylindrical
shape. Inhalator body 1 is made of a suitable resin material such
as polypropylene, polystyrene, ABS resin and the like. Inhalator
body 1 is constituted of cap 3, suction body 4 and capsule body 2
interposed between cap 3 and suction body 4. Cap 3 has air intake
inlet 7A shown in FIG. 2, through which an ambient air is
introduced into cap 3 and flows toward capsule body 2 and suction
body 4 as explained later. Cap 3 has a length shorter than that of
capsule body 2 and is rotatably connected with an upstream side of
capsule body 2. Suction body 4 has air-powder mixture outlet 18
shown in FIG. 2, from which an air-powder mixture formed in
inhalator body 1 is discharged into a user's oral cavity. Suction
body 4 has a length longer than that of capsule body 2 and is
rotatably connected with a downstream side of capsule body 2.
[0037] As illustrated in FIG. 2, capsule body 2 has engaging
projection 2A and engaging groove 2A1 on the upstream end portion.
Engaging projection 2A and engaging groove 2A1 axially adjacent
thereto are engaged with engaging tube portion 3A and engaging
projection 3A1 of cap 3, respectively. Capsule body 2 is coupled
with cap 3 by the engagement of engaging projection 2A and engaging
groove 2A1 with engaging tube portion 3A and engaging projection
3A1, respectively. Capsule body 2 also has at the downstream end
portion, engaging projection 2B and engaging groove 2B1 axially
adjacent thereto. Engaging projection 2B and engaging groove 2B1
are engaged with engaging tube portion 4A and engaging projection
4A1 of suction body 4, respectively. Capsule body 2 is coupled with
suction body 4 by the engagement of engaging projection 2B and
engaging groove 2B1 with engaging tube portion 4A and engaging
projection 4A1, respectively.
[0038] Cocoon-shaped powder receiving chamber 5 is substantially
coaxially disposed within capsule body 2. Powder receiving chamber
5 is provided for receiving a dose of a powder or powder
composition such as particulate medicament, powder tobacco or the
like. Powder receiving chamber 5 is in communication with the
outside of inhalator body 1 through air intake path 6, when the
inhalator is in a use position as explained later by referring to
FIG. 6. The air-powder mixture is formed within powder receiving
chamber 5 when the air flows into powder receiving chamber 5 via
air intake path 6 in the use position of the inhalator.
[0039] Air intake path 6 is provided for introducing the air into
powder receiving chamber 5. Air intake path 6 includes upstream
intake passage 7 formed in cap 3 and downstream intake passage 8
formed in capsule body 2. Upstream intake passage 7 has an upstream
end opening as air intake inlet 7A which is open to a generally
central portion of an axial end face of cap 3. Upstream intake
passage 7 has a downstream end opening that is open to a bottom of
engaging tube portion 3A which mates with an axial end face of
engaging projection 2A, in an offset position relative to the
center axis of cap 3. Downstream intake passage 8 has an upstream
end opening that is open to the axial end face of engaging
projection 2A in an offset position relative to the center axis of
capsule body 2. Downstream intake passage 8 has a downstream end
opening that is open to an upstream end portion of powder receiving
chamber 5 and in substantially alignment with the center axis of
capsule body 2.
[0040] Capsule body 2 and cap 3 are relatively rotatable to be
placed in a non-communication position shown in FIG. 2 and a
communication position shown in FIG. 6. In the non-communication
position, the downstream end opening of upstream intake passage 7
and the upstream end opening of downstream intake passage 8 are out
of alignment with each other. Fluid communication between upstream
intake passage 7 and downstream intake passage 8 is blocked so that
powder receiving chamber 5 is prevented from being fluidly
communicated with the outside of the inhalator. On the other hand,
in the communication position, the downstream end opening of
upstream intake passage 7 and the upstream end opening of
downstream intake passage 8 are in alignment with each other. The
fluid communication between upstream intake passage 7 and
downstream intake passage 8 is established so that powder receiving
chamber 5 is fluidly communicated with the outside of the
inhalator. The opening area at the connection of upstream intake
passage 7 and downstream intake passage 8 may be desirably
regulated by adjusting the alignment of intake passages 7 and 8 to
thereby control a flow amount of the air introduced into powder
receiving chamber 5 and therefore control an amount of the powder
in the air-powder mixture flowing from powder receiving chamber 5
toward air-powder mixture outlet 18.
[0041] Air-powder mixture path 9 extends between powder receiving
chamber 5 and air-powder mixture outlet 18. Air-powder mixture path
9 permits the air-powder mixture to flow from powder receiving
chamber 5 to air-powder mixture outlet 18 when the inhalator is in
the use position.
[0042] First air-powder mixture reservoir 12 is disposed within
air-powder mixture path 9. Air-powder mixture reservoir 12 is
disposed in substantially coaxial with suction body 4. Air-powder
mixture reservoir 12 is adapted to be communicated with powder
receiving chamber 5 through discharge passage 10 and connecting
passage 11 of air-powder mixture path 9. Air-powder mixture
reservoir 12 has a cocoon shape having a volumetric capacity
greater than a volumetric capacity of connecting passage 11.
Air-powder mixture reservoir 12 having the greater volumetric
capacity allows the air-powder mixture flowing thereinto through
connecting passage 11 to be temporarily stored.
[0043] Discharge passage 10 is formed in capsule body 2 so as to be
open to powder receiving chamber 5 at the upstream end and to
engaging projection 2B at the downstream end. An upstream end
opening of discharge passage 10 is open to a downstream end portion
of powder receiving chamber 5 and in substantially alignment with
the center axis of capsule body 2. A downstream end opening of
discharge passage 10 is open to an axial end face of engaging
projection 2B in an offset position relative to the center axis of
capsule body 2. Connecting passage 11 is formed in suction body 4
so as to be open to engaging tube portion 4A at the upstream end
and to air-powder mixture reservoir 12 at the downstream end. An
upstream end opening of connecting passage 11 is open to a bottom
of engaging tube portion 4A which mates with the axial end face of
engaging projection 2B, in an offset position relative to the
center axis of suction body 4. A downstream end opening of
connecting passage 11 is open to an upstream end portion of
air-powder mixture reservoir 12 and in substantially alignment with
the center axis of suction body 4. Capsule body 2 and suction body
4 are relatively rotatable so as to be placed in a
non-communication position shown in FIG. 2 and a communication
position shown in FIG. 6. In the non-communication position, the
downstream end opening of discharge passage 10 and the upstream end
opening of connecting passage 11 are out of alignment with each
other so that fluid communication between discharge passage 10 and
connecting passage 11 is blocked. Powder receiving chamber 5 is
prevented from being fluidly communicated with air-powder mixture
reservoir 12. On the contrary, in the communication position, the
downstream end opening of discharge passage 10 and the upstream end
opening of connecting passage 11 are in alignment with each other.
The fluid communication between discharge passage 10 and connecting
passage 11 is established so that powder receiving chamber 5 is
fluidly communicated with the air-powder mixture reservoir 12. The
opening area at the connection of discharge passage 10 and
connecting passage 11 may be desirably regulated by adjusting the
alignment of discharge passage 10 and connecting passage 11 to
thereby control an amount of the air-powder mixture flowing from
powder receiving chamber 5 into air-powder mixture reservoir
12.
[0044] First diluent air passage 19 is formed in suction body 4 and
communicated with air-powder mixture reservoir 12. Diluent air
passage 19 introduces a diluent air into air-powder mixture
reservoir 12 when the air-powder mixture flows from powder
receiving chamber 5 into air-powder mixture reservoir 12. The
diluent air introduced is merged in the air-powder mixture within
air-powder mixture reservoir 12 to thereby dilute the air-powder
mixture. The diluted air-powder mixture flowing from air-powder
mixture reservoir 12 has a reduced flow rate and a decreased mixing
ratio of the powder relative to the air which are present in the
diluted air-powder mixture. Diluent air passage 19 is constituted
of four passages arranged in crossed manner in lateral section in
this embodiment as shown in FIG. 3. As illustrated in FIG. 3, each
of four diluent air passages 19 has an inlet open to an outer
circumferential surface of suction body 4 and an outlet open to a
circumferential surface of air-powder mixture reservoir 12.
[0045] Second air-powder mixture reservoir 14 is disposed within
air-powder mixture path 9 downstream of first air-powder mixture
reservoir 12. Air-powder mixture reservoir 14 is disposed in
substantially coaxial relation to suction body 4. Air-powder
mixture reservoir 14 is communicated with air-powder mixture
reservoir 12 through communication passage 13 of connecting passage
11 which extends in the axial direction of suction body 4.
Air-powder mixture reservoir 14 has a bell shape having a
volumetric capacity greater than a volumetric capacity of
communication passage 13 when viewed in axial cross-section.
Air-powder mixture reservoir 14 with the greater volumetric
capacity allows the air-powder mixture flowing thereinto through
communication passage 13 to be temporarily stored.
[0046] Dispersion part 15 is disposed within air-powder mixture
path 9 downstream of second air-powder mixture reservoir 14.
Dispersion part 15 is adapted to prevent the powder in the
air-powder mixture flowing from second air-powder mixture reservoir
14 from aggregating together and intimately mix the powder and the
air to form a uniform air-powder mixture. Dispersion part 15
includes dispersion chamber 17 and a plurality of dispersion
passages 16 connected with dispersion chamber 17. Dispersion
passages 16, four passages in this embodiment, connect dispersion
chamber 17 with air-powder mixture reservoir 14. Each of dispersion
passages 16 has an inlet open to air-powder mixture reservoir 14
and an outlet open to dispersion chamber 17. Specifically,
dispersion passage 16 includes an inlet passage portion extending
from an outer peripheral portion of air-powder mixture reservoir 14
in the axial direction of suction body 4. Dispersion passage 16
also includes outlet passage portion 16A that radially inwardly
extends from a downstream side of the inlet passage portion and is
open to an upstream end portion of dispersion chamber 17. As
illustrated in FIG. 4, dispersion chamber 17 has a generally
circular-shaped section and outlet passage portion 16A extends in a
tangential direction of dispersion chamber 17. The air-powder
mixture flowing into dispersion chamber 17 through dispersion
passages 16 forms a swirl flow within dispersion chamber 17. The
swirl flow of the air-powder mixture prevents the powder in the
air-powder mixture from forming an aggregated mass of the
powder.
[0047] Second diluent air passage 20 is formed within suction body
4 in communication with dispersion chamber 17. As seen from FIGS. 2
and 5, four diluent air passages 20 radially extend from grooved
portion 4B on an outer surface of suction body 4 to dispersion
chamber 17. Grooved portion 4B extends along the entire
circumference of the outer surface of suction body 4. Diluent air
passages 20 introduce the ambient air as a diluent air into
dispersion chamber 17 when the air-powder mixture within dispersion
chamber 17 is directed toward outlet 18 by the user's suction.
[0048] Regulator 21 for variably controlling a flow amount of the
diluent air introduced into dispersion chamber 17 via diluent air
passages 20 is axially moveably disposed on grooved portion 4B of
suction body 4. Regulator 21 is in the form of a ring in this
embodiment. Regulator 21 has four regulator holes 21A coming into
alignment with diluent air passages 20 by the axial movement of the
regulator 21. Regulator 21 variably regulates an opening area of
each of diluent air passages 20 to thereby variably control the
flow amount of the diluent air which is merged in the air-powder
mixture within dispersion chamber 17.
[0049] The air-powder mixture passing through dispersion passages
16 and dispersion chamber 17 flows to air-powder mixture outlet 18
from which the air-powder mixture is dispensed into the user's oral
cavity. Air-powder mixture outlet 18 is communicated with
dispersion chamber 17 and open to one axial end surface of suction
body 4. Air-powder mixture outlet 18 is disposed substantially
coaxially with the center axis of suction body 4.
[0050] Referring back to FIG. 1, counter or registration marks 22,
22, 22 are formed on the upstream and downstream end portions of
the outer circumferential surface of capsule body 2, downstream
engaging tube portion 3A of cap 3, and upstream engaging tube
portion 4A of suction body 4, respectively. When counter mark 22 on
the upstream-end side of capsule body 2 is aligned with counter
mark 22 on the downstream-end side of cap 3, upstream and
downstream intake passages 7 and 8 of air intake path 6 are
communicated with each other. When counter mark 22 on the
downstream-end side of capsule body 2 is aligned with counter mark
22 on the upstream-end side of suction body 4, discharge passage 10
and connecting passage 11 of air-powder mixture path 9 are
communicated with each other.
[0051] An operation of the thus-constructed inhalator of the
present invention will be explained hereinafter.
[0052] When the inhalator is in a rest or nonuse position shown in
FIG. 2, upstream and downstream intake passages 7 and 8 of air
intake path 6 are fluidly disconnected from each other and
discharge passage 10 and connecting passage 11 of air-powder
mixture path 9 are fluidly disconnected from each other. In this
state, powder receiving chamber 5 is prevented from being fluidly
communicated with the outside of inhalator body 1 and air-powder
mixture reservoir 12. Thus, if the inhalator is in the rest
position, the powder received within powder receiving chamber 5 can
be restrained from flowing therefrom and inhalator body 1 when the
user carries the inhalator.
[0053] Next, upon using the inhalator, cap 3 and suction body 4 are
rotated relative to capsule body 2 to align respective counter
marks 22 with each other. Regulator 21 is axially moved in grooved
portion 4B so as to desirably adjust the opening area of second
diluent air passage 20. The inhalator is thus placed in a use
position shown in FIG. 6. In the use position, upstream and
downstream intake passages 7 and 8 of air intake path 6 are fluidly
connected with each other and discharge passage 10 and connecting
passage 11 of air-powder mixture path 9 are fluidly connected with
each other. Powder receiving chamber 5 is allowed to be in fluid
communication with the outside of inhalator body 1 and air-powder
mixture reservoir 12. In this state, air-powder mixture outlet 18
of inhalator body 1 is put into the user's oral cavity and the
ambient air is sucked by the user. The air is introduced into air
intake path 6 through air intake inlet 7A. The air then flows into
powder receiving chamber 5 as indicated by arrows in FIG. 6. The
introduced air is admixed with the dose of the powder within powder
receiving chamber 5, forming the air-powder mixture. The air-powder
mixture flows into first air-powder mixture reservoir 12 via
discharge passage 10 and connecting passage 11 of air-powder
mixture path 9. The air-powder mixture is temporarily stored within
air-powder mixture reservoir 12 and admixed with the diluent air
introduced through diluent air passage 19. The thus diluted
air-powder mixture has a decreased flow rate flowing into
communication passage 13, and a reduced mixing ratio of the powder
in the diluted air-powder mixture to the air in the diluted
air-powder mixture.
[0054] The diluted air-powder mixture within first air-powder
mixture reservoir 12 flows into second air-powder mixture reservoir
14 via communication passage 13 and then enters into dispersion
chamber 17 via dispersion passages 16. There occurs a swirl flow of
the diluted air-powder mixture within dispersion chamber 17. The
swirl flow atomizes an aggregated mass of the powder which remains
in dispersion chamber 17, to thereby assure the air-powder mixture
containing fine particles of the powder in a suitably dispersed
state. The air-powder mixture within dispersion chamber 17 is
diluted by the diluent air introduced thereinto through second
diluent air passage 20 and regulator holes 21A of regulator 21. The
thus diluted air-powder mixture then is discharged from air-powder
mixture outlet 18 into the user's oral cavity.
[0055] As be appreciated from the above explanation, the air-powder
mixture flowing from powder receiving chamber 5 is diluted within
air-powder mixture reservoir 12 by the diluent air introduced into
air-powder mixture reservoir 12 through diluent air passage 19. A
flow rate of the air-powder mixture is reduced within air-powder
mixture reservoir 12 by the introduction of the diluent air. As a
result, a part of the dose of the powder received within powder
receiving chamber 5 is sucked by one-time inhalation by the user.
Therefore, the dose of the powder received within powder receiving
chamber 5 can be divided into a plurality of dose parts each being
sucked by the user. Thus, the user can suck a small amount of the
powder that forms each dose part, by one-time inhalation. If it is
required to deposit fine particulate medicament having a small
particle diameter in the bronchi or alveoli of a patient, a dose of
the medicament can be dispensed in parts which are inhaled by
multiple-time inhalation of the user through the inhalator of the
invention. The fine particulate medicament can be prevented from
being deposited in the trachea and be stably deposited in the
bronchi or alveoli by multiple-time inhalation of the dose parts.
The inhalator of the invention can be effectively used for
dispensing a dose of a powder or powder composition such as
particulate medicament and powder tobacco, in parts by
multiple-time inhalation.
[0056] Further, with the arrangement of second diluent air passage
20 and regulator 21 for regulating the opening area of diluent air
passage 20, an amount of the diluent air introduced into dispersion
chamber 17 can be desirably regulated by axially moving regulator
21. A mixing ratio between the powder and the air present in the
air-powder mixture within dispersion chamber 17 can be readily
controlled by the regulation of the diluent air to be introduced.
Accordingly, an amount of the powder which is sucked by one-time
inhalation by the user, can be desirably controlled using regulator
21 depending on the user's liking, kinds of particulate
medicaments, or the like. This can improve a performance of the
inhalator. The amount of the powder for one-time inhalation may be
controlled by regulating the opening area at the connection of
upstream and downstream intake passages 7 and 8 of air intake path
6 or the opening area at the connection of discharge passage 10 and
connecting passage 11 of air-powder mixture path 9.
[0057] Furthermore, with the arrangement of dispersion passages 16
and dispersion chamber 17 at dispersion part 15, the swirl flow of
the air-powder mixture can be produced within dispersion chamber
17, which atomizes an aggregated mass of the powder remaining in
dispersion chamber 17 and forms the air-powder mixture containing
the powder particles in a good dispersed state. This can improve a
dispersion efficiency of the inhalator.
[0058] Further, upstream and downstream intake passages 7 and 8 of
air intake path 6 is arranged to establish and block the fluid
communication between powder receiving chamber 5 and the outside of
inhalator body 1. When the inhalator is in the nonuse position,
upstream and downstream intake passages 7 and 8 are disconnected
from each other so that the fluid communication between powder
receiving chamber 5 and the outside of inhalator body 1 is blocked.
In addition, discharge passage 10 and connecting passage 11 of
air-powder mixture path 9 is arranged to allow and block the fluid
communication between powder receiving chamber 5 and first
air-powder mixture reservoir 12. In the nonuse position of the
inhalator, discharge passage 10 and connecting passage 11 are
disconnected from each other so that the fluid communication
between powder receiving chamber 5 and first air-powder mixture
reservoir 12 is blocked. With this arrangement of intake passages 7
and 8 and discharge passage 10 and connecting passage 11, the
powder received within powder receiving chamber 5 can be prevented
from flowing therefrom toward both air intake inlet 7A and
air-powder mixture reservoir 12 upon the user carrying the
inhalator. This can improve reliability of the inhalator. Further,
when intake passages 7 and 8 are communicated with each other upon
using the inhalator, the opening area of the connection of intake
passages 7 and 8 can be regulated to control the flow amount of the
air flowing into powder receiving chamber 5. Therefore, the amount
of the powder present in the air-powder mixture produced within
powder receiving chamber 5 can be adjusted. Similarly, upon
communication of discharge passage 10 and connecting passage 11,
the opening area of the connection thereof can be regulated to
control the flow amount of the air-powder mixture flowing from
powder receiving chamber 5 into air-powder mixture reservoir 12.
The amount of the powder in the air-powder mixture flowing from
air-powder mixture reservoir 12 toward air-powder mixture outlet 18
can be adjusted, and therefore, the amount of the powder to be
sucked can be adjusted.
[0059] Although two air-powder mixture reservoirs 12 and 14 are
provided within suction body 4 in this embodiment, a single
air-powder mixture reservoir or three or more air-powder mixture
reservoirs may be provided.
[0060] In addition, a capsule chamber for storing a capsule having
a dose of the powder may be substituted for powder receiving
chamber 5. In this case, the capsule within the capsule chamber may
be pierced using a piercing device upon inhalation.
[0061] Further, a shutter member may be provided for blocking and
allowing the fluid communication between powder receiving chamber 5
and the outside of inhalator body 1 and air-powder mixture
reservoir 12, instead of the arrangement of upstream and downstream
intake passages 7 and 8 of air intake path 6 and discharge passage
10 and connecting passage 11 of air-powder mixture path 9. The
shutter member may be rotatably or slidably disposed within air
intake path 6 extending between powder receiving chamber 5 and air
intake inlet 7A and the portion of air-powder mixture path 9 which
extends between powder receiving chamber 5 and air-powder mixture
reservoir 12.
[0062] Furthermore, either one of the upstream end portion of
capsule body 2 and engaging tube portion 3A of cap 3 may have on
the outer circumferential surface a groove circumferentially
extending within a predetermined angular region. The other may have
on the outer circumferential surface a projection engageable with
the groove such that both capsule body 2 and cap 3 are rotatably
moveable to each other in the predetermined angular region. A
similar circumferentially extending groove may be formed on either
one of the outer circumferential surface of the downstream end
portion of capsule body 2 and the outer circumferential surface of
engaging tube portion 4A of suction body 4, and a similar
projection may be formed on the other thereof. If the projections
reach the respective ends of the grooves, the communication between
upstream and downstream intake passages 7 and 8 and the
communication between discharge passage 10 and connecting passage
11 will be established. In this case, counter marks 22 can be
omitted.
[0063] Next, a powder composition for use with inhalators and a
process for administering the powder composition using inhalators,
according to the present invention, will be explained
hereinafter.
[0064] The powder composition is suitable to be administered from
an oral or nasal cavity for deposition in inside parts of the human
body. The powder composition includes at least two kinds of fine
particles selected from a group consisting of a first kind of fine
particle having an aerodynamic mean particle diameter of not less
than 7 .mu.m, a second kind of fine particle having an aerodynamic
mean particle diameter of 5-7 .mu.m, a third kind of fine particle
having an aerodynamic mean particle diameter of 3-3 .mu.m, a fourth
kind of fine particle having an aerodynamic mean particle diameter
of 1-3 .mu.m, and a fifth kind of fine particle having an
aerodynamic mean particle diameter of not more than 1 .mu.m. The
first kind of fine particle having the aerodynamic mean particle
diameter of not less than 7 .mu.m is deposited in an oral cavity or
hypoglottis of a human body. The second kind of fine particle
having the aerodynamic mean particle diameter of 5-7 .mu.m is
deposited in a throat of a human body. The third kind of fine
particle having the aerodynamic mean particle diameter of 3-5 .mu.m
is deposited in a trachea of a human body. The fourth kind of fine
particle having the aerodynamic mean particle diameter of 1-3 .mu.m
is deposited in bronchi of a human body. The fifth kind of fine
particle having the aerodynamic mean particle diameter of not more
than 1 .mu.m is deposited in alveoli of a human body.
[0065] Preferably, the fine particles of the powder composition of
the present invention have a significantly narrow particle size
distribution. More preferably, the fine particles have the particle
size distribution consistent with a predetermined range of an
aerodynamic mean particle diameter which is required for deposition
in the respective parts of the human body.
[0066] The powder composition may be powder tobacco and particulate
medicament. The powder tobacco contains at least two kinds of fine
particles selected from the first, third and fifth kinds of fine
particles as described above. For instance, the powder tobacco may
contain fine particles as a gustatory component which have the
aerodynamic mean particle diameter of 45-55 .mu.m for deposition in
the oral cavity or hypoglottis, fine particles as a stimulatory
component which have the aerodynamic mean particle diameter of 3-3
.mu.m for deposition in the trachea or throat, and fine particles
as an agent which have the aerodynamic mean particle diameter of
0.5-2 .mu.m for deposition in the alveoli or bronchi. A coffee
extract powder may be used for the fine particles as a gustatory
component having the aerodynamic mean particle diameter of 45-55
.mu.m. A menthol extract powder may be used for the fine particles
as a stimulatory component having the aerodynamic mean particle
diameter of 3-5 .mu.m. A nicotine extract powder may be used for
the fine particles as an agent having the aerodynamic mean particle
diameter of 0.5-2 .mu.m. If the powder tobacco is inhaled with the
inhalator, the same taste, stimulus and nicotinic effect as those
obtained by smoking can be obtained.
[0067] The particulate medicament as the powder composition of the
present invention contains at least two kinds of fine particles
selected from the first through fifth kinds of fine particles as
described above. The particulate medicament may contain fine
particles as a gustatory component which have the aerodynamic mean
particle diameter of 60-80 .mu.m for deposition in the oral cavity
or hypoglottis, fine particles as an antiphlogistic agent which
have the aerodynamic mean particle diameter of 4-6 .mu.m for
deposition in the trachea or throat, and fine particles as an agent
which have the aerodynamic mean particle diameter of 1-3 .mu.m for
deposition in the alveoli or bronchi. A powdered troche or candy
may be used for the fine particles as a gustatory component having
the aerodynamic mean particle diameter of 60-80 .mu.m. An
antiphlogistic powder may be used for the fine particles as an
antiphlogistic agent having the aerodynamic mean particle diameter
of 4-6 .mu.m. An antibiotic powder may be used for the fine
particles as an agent having the aerodynamic mean particle diameter
of 1-3 .mu.m.
[0068] In addition, the particulate medicament as the powder
composition of the present invention may be selected from an
analgesic agent, an anginal preparation, an antiallergic agent, an
anti-infective agent, an antihistaminic agent, an anti-inflammatory
agent, an antitussive agent, a bronchodilator agent, a diuretic
agent, an anticholinergic agent, and the like, depending on cure
purposes. These powder agents may have various aerodynamic mean
particle diameters suitable for deposition in different target
parts of the human body.
[0069] If required, the particulate medicament as the powder
composition of the present invention may be used together with a
known excipient acceptable for inhalation into the human body. The
composition of the particulate medicament is prepared in accordance
with the doctor's prescription given on the basis of the patient's
symptom.
[0070] In the administration process of the present invention,
first the powder composition is prepared so as to contain at least
two kinds of fine particles selected from the first to fifth kinds
of fine particles as described above. The at least two kinds of
fine particles of the powder composition may be blended together.
The thus prepared powder composition is supplied to an inhalator
suitable for dispensing a powder into the human body. The powder
composition may be capsulated and then accommodated in the
inhalator. Subsequently, the powder composition supplied is
discharged from the inhalator. If the above-described inhalator of
the present invention is used, the powder composition may be
dispersed within the inhalator and then discharged therefrom
without aggregation of the fine particles of the powder
composition.
[0071] The powder composition and administration process of the
present invention can be suitably used for cure of multiple
diseases using the particulate medicaments which have effects on
the multiple diseases, respectively. Specially, the powder
composition and administration process of the present invention is
suitable for providing analgesia and curing inflammation in the
oral cavity and/or throat, asthma, bronchitis, COPD (chronic
obstructive pulmonary disease), respiratory disease such as
thoracho-infection, and allergosis.
[0072] The inhalators useable in this embodiment are described in
Japanese Patent Applications First Publication Nos. 62-41668 and
9-47509, Japanese Patent Application Second Publication No.
63-6024, and U.S. Pat. No. 5,996,577.
EXAMPLES
[0073] The present invention is described in more detail by way of
examples. However, these examples are only illustrative and not
intended to limit a scope of the present invention thereto.
Example 1
[0074] A dose of a powder tobacco was prepared by blending 5 mg of
coffee extract particulates having an aerodynamic mean particle
diameter of 50 .mu.m, 10 mg of menthol extract particulates having
an aerodynamic mean particle diameter of 4 .mu.m, and 1 mg of
nicotine extract particulates having an aerodynamic mean particle
diameter of 0.5-2 .mu.m together. The thus prepared dose of a
powder tobacco was supplied to a suitable inhalator as described
above and then discharged from the inhalator.
Example 2
[0075] A dose of a particulate medicament mixture was prepared by
blending candy particles having an aerodynamic mean particle
diameter of 70 .mu.m, antiphlogistic agent particles having an
aerodynamic mean particle diameter of 5 .mu.m, antibiotic agent
particles having an aerodynamic mean particle diameter of 2 .mu.m
together in accordance with a doctor's prescription. The thus
prepared dose of a particulate medicament mixture was filled in a
capsule. The thus capsulated dose of a particulate medicament
mixture was accommodated in a suitable inhalator as described above
and then discharged from the inhalator.
[0076] Using the powder composition and the administration process
of the present invention, a dose of the powder composition
containing the at least two kinds of fine particulates different in
mean particle diameter from each other can be selected depending on
the target parts of the human body in which the powder composition
is required to be deposited, and can be deposited in the target
parts by one-time inhalation using the inhalator. Namely,
multi-purpose dosage of particulate medicaments, for instance,
deposition of the particulate medicaments in both of the trachea
and the alveoli or all of the throat, the bronchi and the alveoli,
can be achieved during the one-time inhalation.
[0077] Further, using the powder composition and the administration
process of the present invention, the patient can dispense with
multiple times of inhalation for dosing a plurality of particulate
medicaments required in different prescriptions. Also, any specific
compound of particulate medicaments may not be required for
multi-purpose prescription.
[0078] Furthermore, in a case where the capsulated powder
composition of particulate medicaments having different mean
particle diameters is used, the patient can dispense with adjusting
the amount of the powder composition required for each inhalation
and the mixing ratio of the different kinds of particulate
medicaments.
[0079] The entire contents of basic Japanese Patent Applications
Nos. 2000-363636 filed on Nov. 29, 2000, and 2000-359822 filed on
Nov. 27, 2000, inclusive of the specification, claims and drawings,
are herein incorporated by reference.
[0080] Although the invention has been described above by reference
to certain embodiments of the invention, the invention is not
limited to the embodiments described above. Modifications and
variations of the embodiment described above will occur to those
skilled in the art, in light of the above teachings. The scope of
the invention is defined with reference to the following
claims.
* * * * *