U.S. patent application number 08/981795 was filed with the patent office on 2002-04-11 for method for controlling a population of social insects using 1-arylpyrazoles or 1-heteroarylpyrazoles.
Invention is credited to ZANGIACOMI, LOUIS.
Application Number | 20020042439 08/981795 |
Document ID | / |
Family ID | 26232075 |
Filed Date | 2002-04-11 |
United States Patent
Application |
20020042439 |
Kind Code |
A1 |
ZANGIACOMI, LOUIS |
April 11, 2002 |
METHOD FOR CONTROLLING A POPULATION OF SOCIAL INSECTS USING
1-ARYLPYRAZOLES OR 1-HETEROARYLPYRAZOLES
Abstract
A method for controlling a population of social insects such as
ants, wasps or cockroaches by administering to a minor fraction of
the population an effective amount of a composition that includes a
bait and a 1-phenylpyrazole-type compound, particularly
5-amino-3-cyano-1-[2,6-dic-
hloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl)sulphinyl]-1H-pyrazol-
e.
Inventors: |
ZANGIACOMI, LOUIS;
(DARDILLY, FR) |
Correspondence
Address: |
BURNS DOANE SWECKER & MATHIS L L P
POST OFFICE BOX 1404
ALEXANDRIA
VA
22313-1404
US
|
Family ID: |
26232075 |
Appl. No.: |
08/981795 |
Filed: |
May 27, 1998 |
PCT Filed: |
June 26, 1996 |
PCT NO: |
PCT/FR96/00994 |
Current U.S.
Class: |
514/404 ;
424/405; 424/408; 424/409; 424/84 |
Current CPC
Class: |
A01N 47/02 20130101;
A01N 43/56 20130101; A01N 47/02 20130101; A01N 25/006 20130101;
A01N 43/56 20130101; A01N 25/006 20130101; A01N 47/02 20130101;
A01N 25/00 20130101; A01N 43/56 20130101; A01N 25/00 20130101; A01N
43/56 20130101; A01N 2300/00 20130101; A01N 47/02 20130101; A01N
2300/00 20130101 |
Class at
Publication: |
514/404 ;
424/405; 424/408; 424/409; 424/84 |
International
Class: |
A01N 043/56; A01N
025/00; A01N 025/34; A01N 025/08 |
Foreign Application Data
Date |
Code |
Application Number |
Jun 29, 1995 |
FR |
95/08074 |
Jan 29, 1996 |
FR |
96/01238 |
Claims
1. Method for controlling a population of social insects such as
ants or wasps or cockroaches (or Blatta spp.), characterized in
that an effective amount of a composition comprising a bait and a
compound of formula (I): 2in which: R.sub.1 is a halogen atom or a
CN or methyl group; R.sub.2 is S(O).sub.nR.sub.3; R.sub.3 is alkyl
or haloalkyl; R.sub.4 represents a hydrogen or halogen atom; or a
radical NR.sub.5R.sub.6, S(O).sub.mR.sub.7, C(O)R.sub.7 or
C(O)O--R.sub.7, alkyl, haloalkyl or OR.sub.8 or a radical
--N.dbd.C(R.sub.9)(R.sub.10); R.sub.5 and R.sub.6 independently
represent a hydrogen atom or an alkyl, haloalkyl, C(O)alkyl or
S(O).sub.rCF.sub.3 radical; or R.sub.5 and R.sub.6 may together
form a divalent alkylene radical which may be interrupted by one or
two divalent hetero atoms, such as oxygen or sulphur; R.sub.7
represents an alkyl or haloalkyl radical; R.sub.8 represents an
alkyl or haloalkyl radical or a hydrogen atom; R.sub.9 represents
an alkyl radical or a hydrogen atom; R.sub.10 represents a phenyl
or heteroaryl group optionally substituted with one or more halogen
atoms or groups such as OH, --O-alkyl, --S-alkyl, cyano or alkyl;
R.sub.11 and R.sub.12 represent, independently of each other, a
hydrogen or halogen atom; R.sub.13 represents a halogen atom or a
haloalkyl, haloalkoxy, S(O).sub.qCF.sub.3 or SF.sub.5 group; m, n,
q and r represent, independently of each other, an integer equal to
0, 1 or 2; X represents a trivalent nitrogen atom or a radical
C--R.sub.12, the other three valency positions of the carbon atom
forming part of the aromatic ring; with the proviso that when
R.sub.1 is methyl, then R.sub.3 is haloalkyl, R.sub.4 is NH.sub.2,
R.sub.11 is Cl, R.sub.13 is CF.sub.3 and X is N.
2. Method according to claim 1, characterized in that the
controlled population of social insects is a population of
ants.
3. Method according to claim 1, characterized in that the
controlled population of social insects is a population of
cockroaches.
4. Method for controlling social insects such as ants, wasps or
cockroaches (but preferably cockroaches or Blatta spp.) which have
a common dwelling place or nest in which they live with a
substantial population of their congeners, the said method
comprising a treatment with an effective dose, preferably a dose of
between 0.0001 and 20 grams per 100 m.sup.2, of one or more areas
frequented by, or assumed to be frequented by, the said social
insects, the said area being outside the place of the said common
dwelling but being a place in which the cockroaches circulate or
are assumed to circulate.
5. Method according to one of the preceding claims, characterized
in that the effective amount of composition used is an amount which
is capable of controlling the whole population of social
insects.
6. Method according to one of the preceding claims, characterized
in that the effective amount of composition used is equal to the
dose required to destroy at least 90% of the minor fraction of the
population of social insects to which said composition is applied,
in a time between 2 and 30 days, preferably between 2 and 7
days.
7. Method according to one of the preceding claims, characterized
in that the effective amount of composition used for the method
according to the invention is such that the dose of compound of
formula (I) is between 0.05 and 50 mg per anthill treated,
preferably from 0.1 to 20 mg.
8. Method according to one of the preceding claims, characterized
in that the effective amount of composition used for the method
according to the invention is such that the dose of compound of
formula (I) is between 0.0001 and 20 g per 100 m.sup.2.
9. Method according to one of the preceding claims, characterized
in that the bait employed is chosen from animal and/or plant
proteins, or alternatively from fats, also of animal and/or plant
origin, or even from mono-, oligo- or polyorganosaccharides,
especially from sucrose, lactose, fructose, dextrose, glucose or
even molasses or honey.
10. Method according to one of the preceding claims, characterized
in that the compound of formula (I) used is
5-amino-3-cyano-1-[2,6-dichloro-4-(tr-
ifluoro-methyl)phenyl]-4-[(trifluoromethyl)sulphinyl]-1H-pyrazole.
11. Method according to one of the preceding claims, characterized
in that the composition is applied to a fraction of the population
which is between 1 and 40% of the total population, preferably
between 2 and 20%.
12. Method according to one of the preceding claims, characterized
in that the controlled population of ants is a population of ants
living in the same anthill.
13. Method according to claim 10, characterized in that the minor
fraction of the population to which the composition is applied
consists of harvester workers from the anthill.
14. Method according to one of the preceding claims, characterized
in that the dose of compound of formula (I) in the composition is
between 0.0005 and 0.5%, preferably between 0.001 and 0.2%.
15. Method according to one of the preceding claims, characterized
in that the dose of bait in the composition is between 1 and 99%,
preferably between 30 and 99%.
16. Method according to one of the preceding claims, characterized
in that the composition is applied by placing it in a closed bait
carrier box containing openings which are reserved, on account of
their size, for the exclusive use of ants or Blatta spp., in an
area where these are likely to be found.
17. Method according to claim 16, characterized in that the area is
in a public or private place, such as a living area, or
alternatively on a balcony, a patio, in a garden or in a field.
Description
[0001] The subject of the present invention is a method for
controlling a population of social insects, especially ants, wasps
and cockroaches (or Blatta spp.) It is often very desirable to
combat the drawbacks caused by populations of social insects such
as ants or wasps or cockroaches (or Blatta spp.), especially in the
case of ant populations. Social insects are insects which live in a
large society, or in a colony comprising a large number of such
insects or congeners.
[0002] In the case of ants, for example, these drawbacks generally
stem from the inconvenience caused to individuals by the presence
or passage of columns of ants in living areas or in the immediate
vicinity thereof, such as in the garden or on the patio. The
passage of such columns of ants on the lawn next to a private house
may especially be particularly unpleasant for the resident wishing
to relax by stretching out on the said lawn, on account of the
bites inflicted by certain species.
[0003] The control of ants is also desirable as regards the
cultivation of fruit trees and/or ornamental trees. The reason for
this is that certain species of ant provide a role of defending
aphids against their predators and thus contribute towards
maintaining high populations of aphids, which are harmful to the
good health of the trees concerned and/or to fruit yields.
[0004] Certain species of art sometimes cause even greater
inconvenience. Thus, the pharaoh ant (Monomorium pharaonis) may
create anthills even inside living areas, which, in the case of
blocks of flats and especially of hospitals, poses hygiene
problems.
[0005] Now, the inconvenience and/or damage caused by social
insects such as ants or wasps or cockroaches (or Blatta spp.), and
preferably ants or cockroaches (or Blatta spp.), are in direct
proportion with the sometimes very large number which a population
of such insects may reach, for example, in the case of ants, the
very large number of individuals in the population of an
anthill.
[0006] Methods for controlling ants or wasps or cockroaches (or
Blatta spp.) using insecticidal compounds are known. However, these
methods are not always satisfactory. The reason for this is that
they often destroy only a small portion of the population
concerned, for example, in the case of ants, a fraction of the
workers whose function is to collect food outside the anthill. The
destruction of this population category is not, however, sufficient
to overcome the drawbacks caused by the ants. Indeed, the large
capacity of ants to proliferate and their specialization based on
the needs of the anthill are capable of rapidly compensating for
this destruction, bringing about a new increase in the
population.
[0007] The known methods moreover have the drawback that it is very
difficult to treat all the individuals of the population,
especially on account of the fact that, as regards ants, the
anthills are fairly inaccessible, since they are generally located
at a depth of several tens of centimeters below the surface of the
ground.
[0008] One aim of the present invention is to overcome these
drawbacks.
[0009] Another aim of the present invention is to ensure the
destruction of the larvae present in the anthill, or more generally
in the nest or dwelling place of the said social insects.
[0010] Another aim of the present invention is to ensure the
destruction of the laying females present in the anthill, or more
generally in the nest or dwelling place of the said social
insects.
[0011] Another aim of the present invention is to propose a method
which allows the definitive destruction of all or virtually all of
a population of social insects such as ants or wasps or cockroaches
(or Blatta spp.), preferably such as ants or cockroaches (or Blatta
spp.).
[0012] It has now been found that these aims could be totally or
partly achieved by means of the control method according to the
invention which is described in detail below.
[0013] The subject of the present invention is thus a method for
controlling a population of social insects such as ants or wasps or
cockroaches (or Blatta spp.), characterized in that an effective
amount of a composition comprising a bait and a compound of formula
(I): 1
[0014] in which:
[0015] R.sub.1 is a halogen atom or a CN or methyl group;
[0016] R.sub.2 is S(O).sub.nR.sub.3;
[0017] R.sub.3 is alkyl or haloalkyl;
[0018] R.sub.4 represents a hydrogen or halogen atom; or a radical
NR.sub.5R.sub.6, S(O).sub.mR.sub.7, C(O)R.sub.7 or C(O)O--R.sub.7,
alkyl, haloalkyl or OR.sub.8, or a radical --N.dbd.C (R.sub.9)
(R.sub.10);
[0019] R.sub.5 and R.sub.6 independently represent a hydrogen atom
or an alkyl, haloalkyl, C(O) alkyl or S(O).sub.rCF .sub.3 radical;
or R.sub.5 and R.sub.6 may together form a divalent alkylene
radical which may be interrupted by one or two divalent hetero
atoms, such as oxygen or sulphur;
[0020] R.sub.7 represents an alkyl or haloalkyl radical;
[0021] R.sub.8 represents an alkyl or haloalkyl radical or a
hydrogen atom;
[0022] R.sub.9 represents an alkyl radical or a hydrogen atom;
[0023] R.sub.10 represents a phenyl or heteroaryl group optionally
substituted with one or more halogen atoms or groups such as OH,
--O-alkyl, --S-alkyl, cyano or alkyl;
[0024] R.sub.11 and R.sub.12 represent, independently of each
other, a hydrogen or halogen atom;
[0025] R.sub.13 represents a halogen atom or a haloalkyl,
haloalkoxy, S(O).sub.qCF.sub.3 or SF.sub.5 group;
[0026] m, n, q and r represent, independently of each other, an
integer equal to 0, 1 or 2;
[0027] X represents a trivalent nitrogen atom or a radical
C--R.sub.12, the other three valency positions of the carbon atom
forming part of the aromatic ring;
[0028] with the proviso that when R.sub.1 is methyl, then R.sub.3
is haloalkyl, R.sub.4 is NH2, R.sub.11 is Cl, R.sub.13 is CF.sub.3
and X is N.
[0029] The alkyl radicals in the definition of formula (I)
generally comprise from 1 to 6 carbon atoms. The ring formed by the
divalent alkylene radical representing R.sub.5 and R.sub.6, as well
as by the nitrogen atom to which R.sub.5 and R.sub.6 are attached,
is generally a 5-, 6-or 7-membered ring.
[0030] A preferred class of compounds of formula (I) comprises the
compounds where R.sub.1 is CN and/or R.sub.3 is haloalkyl and/or
R.sub.4 is NH.sub.2 and/or R.sub.11 and R.sub.12 are, independently
of one another, a halogen atom and/or R.sub.13 is haloalkyl.
[0031] Populations of ants are more especially preferred among the
populations of social insects which may be controlled using the
method according to the invention.
[0032] In the sense of the present invention, control of a
population of social insects such as ants, wasps or cockroaches is
understood to mean the control of the said insects, and more
particularly the total or virtually total destruction of the said
population, in other words the destruction of more than 60%,
preferably more than 70% and even more preferably of 95 to 100%, of
the said population.
[0033] An effective amount of the composition used in the method
according to the invention is understood to mean an amount which is
capable of controlling the whole population of social insects such
as a population of ants or wasps or cockroaches (or Blatta
spp.).
[0034] More particularly, the invention relates to a method for
treating social insects such as ants, cockroaches or wasps with an
effective amount of active material of formula (I), this effective
amount of composition being an amount used equal to the dose
required to destroy at least 90% of the minor fraction of the
population of social insects to which the said composition is
applied, within a period of between 2 and 30 days, preferably
between 2 and 7 days. The minor fraction often corresponds in
practice to the population living or circulating outside the common
dwelling place or nest.
[0035] According to a more preferred variant of the invention, when
the population of social insects is a population of ants, the
effective amount of composition used for the method according to
the invention is generally such that the dose of compound of
formula (I) is between 0.05 and 50 mg per anthill treated,
preferably from 0.1 to 20 mg. This effective amount may be
determined more precisely within this range by systematic tests,
depending on the species of ant whose population it is desired to
control, and also depending on the size and extent of the anthills
which may vary according to the nature of these species.
[0036] The invention thus also relates to a method for controlling
social insects such as ants, wasps or cockroaches (but preferably
cockroaches or Blatta spp.) which have a common dwelling place or
nest in which they live with a substantial population of their
congeners, the said method comprising a treatment with an effective
dose, preferably a dose of between 0.0001 and 20 grams per 100
m.sup.2, of one or more areas frequented by, or assumed to be
frequented by, the said social insects (preferably cockroaches),
the said area being outside the place of the said common dwelling
but being a place in which the cockroaches circulate or are assumed
to circulate.
[0037] The ants which may be controlled using the method according
to the invention are especially:
[0038] ants of the genus Lasius, for example the black ant (Lasius
niger);
[0039] the pavement ant (Tetramorium caespitum);
[0040] the pharaoh ant (Monomorium pharaonis);
[0041] the Argentine ant (Iridomyrmex humilis);
[0042] fire ants belonging to the genus Solenopsis;
[0043] fungal ants, such as the ants of the genus Acromyrmex (for
example the cassava ant) and the ants of the genus Atta.
[0044] The cockroaches which may be treated by the method of the
invention are mainly Blatella germanica, Blatella orientalis,
Periplaneta americana, Periplaneta fuliginosa.
[0045] The compound of formula (I) may be prepared according to one
of the methods described in Patent Applications WO 87/3781,
93/6089, 94/21606, and EP 295,117 or alternatively by another
method from within the general experience of those skilled in the
art competent in chemical synthesis. This compound is also referred
to in the remainder of the present text by the term active
material.
[0046] The bait employed in the composition used in the method
according to the invention is a product which is sufficiently
appetizing to incite social insects such as ants or wasps or
cockroaches (or Blatta spp.) to eat it. In the case of ants, this
bait is chosen, for example, but not exclusively, from animal
and/or plant proteins, or alternatively from fats, also of animal
and/or plant origin, or even from mono-, oligo- or
polyorganosaccharides, especially from sucrose, lactose, fructose,
dextrose, glucose or even molasses or honey.
[0047] According to a particularly advantageous variant of the
invention, the compound of formula (I) used in the invention is
5-amino-3-cyano-1-[2,
6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoro- methyl)
sulphinyl]-1H-pyrazole.
[0048] The minor fraction of the population to which the
composition employed in the method according to the invention is
applied is generally between 1 and 50% of the total population,
preferably between 2 and 20%.
[0049] According to a preferred variant of the invention, the
population of ants which may be controlled using the method
according to the invention is a population of ants living in the
same anthill. In this case, the minor fraction of the population to
which the composition is applied generally consists of workers
whose function is to collect food from outside the anthill, these
being known as the harvester workers of the anthill.
[0050] According to another preferred variant of the invention, the
ant or cockroach population which can be controlled by means of the
method according to the invention is a population of cockroaches
living in the same common dwelling place for cockroaches.
[0051] The dose of compound of formula (I) in the composition used
is between 0.0005 and 0.5%, preferably between 0.001 and 0.2%. In
the present text, the percentages corresponding to doses are,
except where otherwise mentioned, weight/weight percentages.
[0052] The dose of bait in the composition used is generally
between 1 and 99%, preferably between 30 and 99%. The composition
used may also comprise other additives such as a solvent for the
active material, a flavouring, a preserving agent, a dye or a
bitter agent.
[0053] According to a particularly advantageous variant of the
method according to the invention, it is preferred to apply the
composition by placing it in a closed bait-carrier box containing
openings which are reserved, on account of their size, for the
exclusive use of ants or Blatta spp., or insects of similar size,
in an area where these insects are likely to be found. The area may
especially be in a public or private place, such as a living area,
or alternatively on a balcony, a patio, in a garden or in a field.
This variant is of improved safety, since it concerns an active
material which is liable to present a risk in the case of
accidental contact or ingestion by pets or children.
[0054] The invention as described in the present application also
applies to termites, but is preferred for ants, cockroaches and
wasps.
[0055] In the examples which follow the compound of formula (I)
used is
5-amino-3-cyano-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluorom-
ethyl)sulphinyl]-1H-pyrazole, referred to as compound A.
EXAMPLE 1
[0056] A watch glass containing 10 g of a 0.05% dispersion of
compound A in honey is placed 20 cm from the entrance to an active
anthill. The ants are of the species Lasius niger, for which the
fraction of workers whose function is to collect food is in the
region of 10% of the total population. The total population is
estimated by a count carried out on an untreated anthill, referred
to as the control, containing 10,000 individuals.
[0057] During the first 2 days, it is observed that the ants head
in a column from the anthill to the watch glass, stop to take up
the dispersion and then return to the anthill.
[0058] After 15 days, no further surface activity is observed
around the anthill. An update on the latter is then obtained by
excavation.
[0059] A destruction rate of greater than 99% is observed.
[0060] In particular, all the larvae have been destroyed.
EXAMPLE 2
[0061] Tests are carried out on Blatella Germanica cockroaches in
boxes 36.times.24.times.14 cm in size. These boxes comprise a
source of water, a shelter consisting of piled pieces of cardboard,
and additional food consisting of biscuit pieces.
[0062] 15 cockroaches are introduced into the box without bait.
[0063] After 24 hours, a 2.7 g pellet of bait with 1.35 mg of
product of formula (I) is introduced into the box.
[0064] After a further 8 hours, the bait and the additional food
are removed and 15 new healthy cockroaches are introduced.
[0065] 64 hours after the introduction of the bait (ie. 56 hours
after removing the bait and introducing new cockroaches), 98.6% of
the cockroaches are dead. The level is 100% after 88 hours.
* * * * *