U.S. patent application number 09/796242 was filed with the patent office on 2002-02-28 for ionic silver complex.
This patent application is currently assigned to Ira Jay Newman. Invention is credited to Newman, Ira Jay, Washburn, David.
Application Number | 20020025344 09/796242 |
Document ID | / |
Family ID | 22318046 |
Filed Date | 2002-02-28 |
United States Patent
Application |
20020025344 |
Kind Code |
A1 |
Newman, Ira Jay ; et
al. |
February 28, 2002 |
Ionic silver complex
Abstract
The invention relates to a substantially non-colloidal solution
made by combining ingredients comprising (a) water; (b) a source of
free silver ions; and (c) a substantially non-toxic, substantially
thiol-free, substantially water-soluble complexing agent.
Inventors: |
Newman, Ira Jay; (Fort
Lauderdale, FL) ; Washburn, David; (West Palm Beach,
FL) |
Correspondence
Address: |
Lawrence A. Villanueva
NEEDLE & ROSENBERG, P.C.
The Candler Building, Suite 1200
127 Peachtree Street, N.E.
Atlanta
GA
30303-1811
US
|
Assignee: |
Ira Jay Newman
|
Family ID: |
22318046 |
Appl. No.: |
09/796242 |
Filed: |
February 28, 2001 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
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09796242 |
Feb 28, 2001 |
|
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|
09435158 |
Nov 5, 1999 |
|
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60107710 |
Nov 9, 1998 |
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Current U.S.
Class: |
424/618 ;
514/495 |
Current CPC
Class: |
A61K 33/38 20130101;
A61P 31/04 20180101; Y10S 514/836 20130101; A61P 1/02 20180101;
Y10S 514/912 20130101; A61P 31/12 20180101; A01N 25/02 20130101;
A61K 9/0034 20130101; A01N 2300/00 20130101; A01N 59/16 20130101;
A01N 59/16 20130101; A61P 17/10 20180101; A61K 47/12 20130101; Y10S
514/859 20130101; A61K 9/0095 20130101; A61K 47/18 20130101; A61K
9/0048 20130101; A61P 31/16 20180101; A61P 27/02 20180101; A61K
9/0056 20130101; A61K 9/08 20130101; A01N 59/16 20130101; A61K
9/0014 20130101; Y10S 424/06 20130101; Y10S 424/13 20130101; A61P
31/10 20180101 |
Class at
Publication: |
424/618 ;
514/495 |
International
Class: |
A61K 033/38; A61K
031/28 |
Claims
1. A substantially non-colloidal solution made by combining
ingredients comprising: (a) water; (b) a source of free silver
ions; and (c) a substantially non-toxic, substantially thiol-free,
substantially water-soluble complexing agent.
2. The substantially non-colloidal solution of claim 1, wherein the
non-colloidal solution possesses less than about ten weight percent
of free silver based on the weight of total silver.
3. The substantially non-colloidal solution of claim 2, wherein the
non-colloidal solution possesses less than about one weight percent
of free silver based the weight of total silver.
4. The substantially non-colloidal solution of claim 3, wherein the
non-colloidal solution possesses less than about one-tenth of a
percent by weight of free silver based on the weight of total
silver.
5. The substantially non-colloidal solution of claim 1, wherein the
non-colloidal solution possesses greater than about twenty parts of
total silver per million parts of the non-colloidal solution.
6. The substantially non-colloidal solution of claim 5, wherein the
non-colloidal solution possesses greater than about fifty parts of
total silver per million parts of the non-colloidal solution.
7. The substantially non-colloidal solution of claim 6, wherein the
non-colloidal solution possesses greater than or equal to about one
hundred parts of total silver per million parts of the
non-colloidal solution.
8. The substantially non-colloidal solution of claim 1, wherein the
source of free silver ions comprises silver oxide, trisilver
citrate, or silver acetate.
9. The substantially non-colloidal solution of claim 8, wherein the
source of free silver ions comprises silver oxide.
10. The substantially non-colloidal solution of claim 1, wherein
the substantially non-toxic, substantially thiol-free,
substantially water-soluble complexing agent comprises a carboxylic
acid, or a primary, secondary or tertiary amine.
11. The substantially non-colloidal solution of claim 10, wherein
the substantially non-toxic, substantially thiol-free,
substantially water-soluble complexing agent comprises amino acids
or hydroxy acids.
12. The substantially non-colloidal solution of claim 11, wherein
the amino acids comprise glycine, alanine, valine, leucine,
isoleucine, methionine, proline, phenylalanine, tryptophan, serine,
threonine, tyrosine, asparagine, glutamine, aspartic acid, glutamic
acid, lysine, arginine, or histidine.
13. The substantially non-colloidal solution of claim 12, wherein
the hydroxy acids comprise glycolic acid, lactic acid, malic acid,
tartaric acid, citric acid, or mandelic acid.
14. The substantially non-colloidal solution of claim 13, wherein
the citric acid is dibasic citrate.
15. The substantially non-colloidal solution of claim 1, wherein
the free silver ions are present in the substantially non-colloidal
solution in an anti-microbially effective amount.
16. The substantially non-colloidal solution of claim 1, wherein
the ingredients further comprise a source of counter-ions.
17. The substantially non-colloidal solution of claim 1, wherein
the source of counter-ions comprises potassium ions, or calcium
ions.
Description
CROSS-REFERENCE TO RELATED APPLICATIONS
[0001] This application claims priority to U.S. Provisional Patent
Application No. 60/107710, filed Nov. 9, 1998.
BACKGROUND OF THE INVENTION
[0002] 1. Field of the Invention
[0003] This invention relates to solutions including complexed
ionic silver. More particularly, it relates to solutions including
complexed ionic silver wherein the solutions convey health benefits
through their use or application.
[0004] 2. Description of Related Art
[0005] Silver has been known to act antimicrobially as an agent in
and on the body of humans as well as other animals, and to be
relatively non-toxic to mammalian cells when used in the minute
quantities needed to be antimicrobially effective. The most
effective form of silver for antimicrobial use is as ions in
solution. Silver ions have been shown in the past to have
antibacterial, antiviral and antifungal qualities, and to
contribute directly to the regeneration of tissue. While the exact
method by which silver ions perform these functions is not known,
it is believed that they may (1) disrupt the respiratory functions,
or (2) disrupt membrane functionality of single-celled
microorganisms, or (3) link to the cell's DNA and disrupt cell
functions. It is not conventionally understood why silver ions
appear to some to be effective at regenerating tissue, which
apparently involves more than acting as an antimicrobial agent.
[0006] During recent years, ionic silver substances have been
undergoing a substantial resurgence in popularity, and are
increasingly regarded as a reasonably safe and effective
antimicrobial agent. Silver ion substances are increasingly being
used in medical applications as well as by those seeking a natural
alternative to traditional antibiotic medications. Ionic silver
substances are being used in topical dressings to treat wounds and
to prevent and treat infections. They are also being used for water
supply sanitation for public utilities, for pharmaceutical
equipment sanitation, and for killing germs including the germ that
causes Legionnaires' Disease in the water systems of hospitals.
Tooth brushes are now being introduced that release silver ions in
order to fight oral bacteria.
[0007] However, delivering silver ions for utilization in or on the
body is a challenge because silver ions are electrically attracted
to a host of substances in and on the body, resulting in the silver
ions rapidly forming complexes or compounds wherein the ion is no
longer available to perform the appropriate antimicrobial function.
A controlled, gradual release of silver ions is desirable for
achieving appropriate use of silver ions in or on the body in order
to offset this phenomenon, and is especially challenging for
antimicrobial use of silver ions internally such as upon oral
ingestion. If free silver, defined as silver ions which are not
part of a complex or compound, and are therefore biologically
available, are delivered at once to the body, there is only
opportunity for them to perform the antimicrobial function for an
instant where they make contact with the body or the oral tissue
before being rendered inactive.
[0008] The desirable characteristics of an antimicrobial ionic
silver formulation are that it gradually releases its silver
content as free silver ions upon ingestion or upon topical
application in a manner that is slow enough to sustain the
antimicrobial functionality for a sufficient period of time while
also being rapid enough to be substantially effective, that it
facilitate mobility of the silver through the body upon oral
ingestion prior to gradually releasing its silver content as
available free silver ions, and that it be nontoxic to the
body.
[0009] Topical applications of ionic silver do not require a
controlled, gradual release of silver ions to the degree that
internal, oral ingestion applications require it because there is a
lower presence of agents with which the silver ions can bind up and
form complexes or compounds upon topical exposure as compared with
ingestion for internal use. At least one product has been recently
introduced that consists of a film dressing impregnated with a
complex that gradually releases silver ions upon exposure to the
body's chemistry.
[0010] Previously, some silver-containing chemical substances, such
as silver nitrate, have been utilized in an effort to gain the
antimicrobial benefits of silver ions, but these substances have
proven minimally effective in or on the body because they
immediately deliver all of their silver content as free silver
ions. Some such substances, such as silver nitrate, are undesirably
toxic to the human body when administered in typical doses.
[0011] Colloidal silver is a substance which has been in use for
about a hundred years. It provides a reasonable degree of
controlled release and mobility of silver ions in and on the body.
Colloidal silver is apparently made up of minute particles of
silver, associated with silver ions that comprise a small
percentage of such particles. The mass of these particles provide a
degree of controlled, gradual release of silver ions as the body's
chemistry breaks down these particles.
[0012] However, the electrolysis process that is used to make most
colloidal silver has substantial limitations and does not enable
adequate consistency in terms of parts per million (PPM) of silver
relative to the total solution by molar weight, particle size, or
percentage of ions, for most desired applications. Additionally,
purity of the substance is typically limited because electrolytes
must usually be added to the water during the production method,
the most common of which is sodium. Oxides typically form during
production, often resulting in an undesirable yellow or brown
color. Moreover, the potency of most electrically produced
colloidal silver is inherently limited. After a concentration of
approximately 5 PPM of silver (in some cases up to approximately 20
PPM of silver) is reached, the production method typically fails to
continue yielding electron-deficient silver particles. The
particles formed after such a concentration is reached are
typically not capable of performing antimicrobial functions as do
the particles that are initially produced prior to reaching this
approximate level of total silver concentration (the aggregate of
the complexed silver and the free, available silver in the
water-based solution).
[0013] The term colloidal means "something suspended in a
dissimilar medium," and shelf life is, therefore, inherently
limited because the colloidal silver particles gradually settle out
of the water. Colloidal particles are not dissolved in the water
medium; they are not in solution. The suspension is a result of,
for example, Brownian motion which is insufficient to keep the
particles from settling out over time. Some colloidal silver
substances have stabilizing agents such as proteins added to the
formula, but these tend to further hinder the availability of the
silver ions to the body. What is therefore needed are compositions
comprising silver ions, and methods of making and using such
compositions, that address the aforementioned problems.
SUMMARY OF THE INVENTION
[0014] In an aspect, the invention relates to a substantially
non-colloidal solution made by combining ingredients comprising (a)
water; (b) a source of free silver ions; and (c) a substantially
non-toxic, substantially thiol-free, substantially water-soluble
complexing agent.
DETAILED DESCRIPTION
[0015] The inventors have unexpectedly discovered that a
substantially non-colloidal solution made by combining ingredients
comprising (a) water; (b) a source of free silver ions; and (c) a
substantially non-toxic, substantially thiol-free, substantially
water-soluble complexing agent overcomes many of the limitations
inherent in the aforementioned forms of ionic silver substances and
has wide application in and on the body.
[0016] The inventive, substantially non-colloidal solution provides
silver ion concentrations well above those typically provided by
colloidal silver products. The production method provides a
typically consistent formulation. The inventive formulation is
highly stable, has many years of shelf life, and maintains its
consistency and structure under a wide range of environmental
conditions. Substantially wide concentration ranges of complexed
silver are attainable without significantly compromising the
desirable characteristics of the product. The composition of the
invention efficiently provides for substantial mobility of the
silver complex through the body and for controlled decomplexing of
its silver content, whereupon it gradually releases silver as
available free silver ions, upon introduction of the product to the
body's chemistry internally through oral ingestion or upon topical
application.
[0017] Further, the inventive, substantially non-colloidal solution
is relatively nontoxic to the human body at typical doses.
[0018] The inventive substantially non-colloidal solutions are made
from ingredients comprising water, a source of free silver ions;
and a substantially non-toxic, substantially thiol-free,
substantially water-soluble complexing agent.
[0019] Water usable in the practice of this invention should be
relatively pure. Suitable types of water include: deionized water,
distilled water, reverse osmosis filtered water, reagent grade
water and USP grade water suitable for use in pharmaceuticals. The
water is desirably substantially free of contaminants, such as
parasites, pathogens, chemical contaminants, and particulate
contamination.
[0020] The source of silver ions may be virtually any compound or
complex which includes silver ions as a constituent, from which
those silver ions can be obtained in order to be complexed with the
recited complexing agent or to become free silver ions as part of
the inventive solution. Sources of silver ions comprise silver
oxide, trisilver citrate, silver acetate, water soluble silver
salts or any number of other sources of silver without departing
from the scope of the invention. In a preferable embodiment, the
source of silver ions is silver oxide (AgO). On complexing, silver
oxide eliminates a superfluous counter ion, hydroxide, which is
innocuous since hydroxide is already present in the solution.
[0021] The substantially non-toxic, substantially thiol-free,
substantially water-soluble complexing agent serves primarily to
provide a "controlled release" of biologically active silver ions.
In the context of the invention, complexing agent may be taken to
mean an ionic material with which silver ions are complexed in such
a manner that the complexing agent forms a weak bond with the
silver ions wherein the missing electron position which is a
characteristic of the silver ion is filled by an electron of the
complexing agent. The substantially non-toxic, substantially
thiol-free, substantially water-soluble complexing agent may
comprise a carboxylic acid, or a primary, secondary or tertiary
amine. In the context of this invention, substantially non-toxic
may be taken to mean that the recited complexing agent, when
present in the inventive solution in usual amounts according to the
invention, and when administered as part of the inventive solution
in usual dosage amounts of the inventive solution, creates little
or no toxic effects in a host to which the inventive solution is
administered. In an embodiment, the substantially non-toxic,
substantially thiol-free, substantially water-soluble complexing
agent comprises amino acids or hydroxy acids. In a preferable
embodiment, the amino acids comprise glycine, alanine, valine,
leucine, isoleucine, methiorine, proline, phenylalanine,
tryptophan, serine, threonine, tyrosine, asparagine, glutamine,
aspartic acid, glutamic acid, lysine, arginine, or histidine. In
another preferable embodiment, the hydroxy acids comprise glycolic
acid, lactic acid, malic acid, tartaric acid, citric acid, or
mandelic acid. In a more preferable embodiment, the citric acid
comprises dibasic citrate. Citrate, a key constituent of the
metabolic system, is aggressively drawn to the cells throughout the
body and provides an efficient delivery system for spreading the
silver through the body before decomplexing takes place and the
silver is gradually released as available free silver ions. Also
useful are acetic acid; certain crown ethers; primary, secondary or
tertiary amines, such as ethanolamine, and other conventionally
known substantially non-toxic, substantially thiol-free,
substantially watersoluble complexing agents.
[0022] In an embodiment, the inventive substantially non-colloidal
solution possesses greater than about twenty parts of silver per
million parts of the non-colloidal solution. In the context of this
invention, PPM is defined as parts of total silver to 1,000,000
parts of the total solution including the water base and all
substances contained in it by weight. In another embodiment, the
substantially non-colloidal solution possesses greater than about
fifty parts of total silver per million parts of the non-colloidal
solution. In a more preferable embodiment, the substantially
non-colloidal solution posesses greater than or equal to about one
hundred parts of total silver per million parts of the
non-colloidal solution. Higher parts per million of total silver
are desirable, as biological effectiveness increases as PPM free
silver increases.
[0023] 100 PPM of silver is a desirable level for the total
concentration of silver because it provides a highly effective
concentration of silver yet the concentration is low enough to
facilitate ease of measuring and dispensing the small dosages
appropriate for small children and small animals. However, the
amount of silver can vary substantially, within solubility limits,
without departing from the scope of the invention, as long as the
other elements are varied in relative proportion to the silver. In
another embodiment, the inventive solution may be comprised of as
little as about 10 PPM of silver or as much as about 10,000 PPM of
silver without departing from the scope of the invention.
[0024] In an aspect of the invention, counter ions may be utilized.
Such counter ions may be used to balance the charge present in the
recited complexing agent, if necessary. Sources for counter ions
suitable for use in this invention include those conventionally
known sources of counter ions. Any suitable source of counter ions
may be used where the complexing agent is such that a counter ion
is required to maintain the electrical stability of the silver
complex, so long as the counter ion used does not compete with the
silver for the complexing agent. In a preferable embodiment, the
source of counter-ions comprises potassium ions, or calcium
ions.
[0025] In an aspect of the invention, the inventive non-colloidal
solution possesses less than about ten weight percent of free
silver based on the weight of total silver. In an aspect of the
invention, the non-colloidal solution possesses less than about one
weight percent of free silver based on the weight of total silver.
In an aspect of the invention, the non-colloidal solution possesses
less than about one-tenth of a weight percent of free silver based
on the weight of total silver. A relatively low amount of free
silver as compared to total silver (including non-free silver or
complexed silver), is retained in a non-reacted state in the
inventive solution, until released over time by the equilibrium
driving force. This controlled release aspect of the inventive
formulation is desirable, as activity is retained over time.
[0026] The preferred embodiment of the invention, containing a
complex of citrate and silver with potassium as a counter ion, may
include the following complex of ions in a solution of relatively
pure water:
AgCOOCH.sub.2COHCOOCH.sub.2COOH.sup.-1(aq)Ag.sup.+(aq)+COOCH.sub.2COHCOOCH-
.sub.2COOH.sup.2-(aq)
[0027] In a preferable embodiment the inventive solution may be
made by mixing silver oxide, citric acid and tripotassium citrate
in an approximately 1*4 molar ratio, respectively, in sufficient
pure water to produce a silver concentration of 100 parts per
million. Other formulations which result in an approximate 1:2
molar ratio to an approximate 1:20 molar ratio of silver to dibasic
citrate in no way depart from the scope of the invention.
Generally, a preferable molar ratio (as dry ingredient or as
solution) of silver to complexing agent is from about 1:1 to about
1:200, more preferably from about 1:1.5 to 1:50, most preferably
from about 1:2 to about 1:20.
[0028] In another preferable embodiment, the free silver ions are
present in the substantially non-colloidal solution in an
anti-microbially effective amount.
[0029] The inventors have also produced the product following the
general procedures described above but reducing the amounts of
citric acid and of potassium citrate to half of the amounts
described above. Numerous other variations can also be utilized
with these starting ingredients provided that the ratio of citric
acid to potassium citrate is generally maintained. Likewise, the
amount of silver oxide may be substantially increased or decreased
provided that a reasonably commensurate adjustment is made in the
relative amounts of citric acid and of potassium citrate to silver
oxide although, as demonstrated by the fact that the product was
successfully produced upon changing the ratio of silver oxide to
citric acid and to potassium citrate by 100%, substantial latitude
exists with regard to that ratio.
[0030] As previously stated herein, numerous alternative source
ingredients for yielding the silver ion, complexing agent, and
counter ion for the preferred embodiment of the invention may also
be used, requiring appropriately adjusted quantities, and,
likewise, numerous other complexing agents and, if required,
counter ion agents, may be selected as the constituents of the
product as well, also requiring the appropriately adjusted
quantities of the appropriate source ingredients necessary to
produce the desired product.
[0031] It has often been claimed that ionic silver can kill over
650 disease-causing germs. The invention is absolutely harmless to
the body when used in the low quantities needed for the
antimicrobial action to occur, especially since the formulation
provides an efficiently controlled, gradual release of free silver
ions (provided that the complexing agent is nontoxic), requiring
less silver ingestion in order to obtain the benefits of silver ion
activity that other substances cannot render with substantially
higher levels of silver ingestion.
[0032] Ionic silver is used for literally hundreds of conditions,
including eye and ear infections, nose, sinus and gum infections,
acne, sore throats, colds and flu, candida, bladder and vaginal
infections, cuts and bums, many skin conditions, bug bites,
fighting nail and skin fungus, healing sunburn, alleviating diaper
rash and bed sores, providing a soothing skin treatment after
shaving, and use as a mouth rinse. Body odors are caused by
bacteria in the perspiration, which is often alleviated upon
application of the invention, clearly demonstrating how effectively
it kills bacteria. Ionic silver is also used for treating ulcers,
both in fighting the bacteria that can aggravate an ulcer and in
repairing the damaged stomach lining. Ionic silver is used for many
severe conditions as well, including, for example, tuberculosis,
Epstein-Barr Virus, Lyme Disease, Legionnaires' Disease,
bronchitis, chicken pox, and numerous others. There are actually
few germ-related conditions, or conditions requiring the repair of
tissue, for which ionic silver is not used, since many claim it is
not only effective in killing most bacteria but also many if not
most fungus and viruses. Some reports indicate that it is also
effective against a number of parasites that might invade the body.
Ionic silver is also reported by some researchers to be effective
at treating cancer and HIV.
[0033] Other uses for ionic silver range from purifying bottled
water by placing some in the water, to retardation of food spoilage
at home. Recent studies show that over 30 percent of bottled water
contains bacteria levels above safety limits, which can readily be
addressed with a few drops of the invention being added to the
water. Spraying sliced fruits with the formulation of the invention
can keep them fresh up to a week before spoilage, clearly
demonstrating how effectively the invention kills bacteria on
foods. It is also used to reverse existing contamination of
foods.
[0034] Ionic silver is also considered by many to be very useful in
oral irrigation systems designed for consumer use, that spray a
fine stream of water in the mouth, in fighting infection and
healing gums. Ionic silver is even reputed to be quite effective in
facilitating the growth of hair in the local area on which it is
topically applied.
[0035] In virtually all applications for which ionic silver is
used, the advantages of a relatively high PPM of silver, a
controlled, gradual release of available free silver ions and, in
the case of the preferred embodiment of the invention, the benefit
of citrate as a carrier on internal use together with the lack of
toxicity and minimum likelihood of incurring mutated strains of
germs, all serve to provide substantially superior benefits to
those who would use the product for any of the myriad of conditions
for which ionic silver would be used.
[0036] The product can readily be bottled or packaged with a
variety of types of dispensers to further facilitate its
usefulness. A bottle with a dropper is most convenient for eye
drops, ear drops and nose drops. Alternatively, a plastic squeeze
bottle can serve as a convenient dispenser for eye drops and ear
drops, while the same with a nasal sprayer feature can readily
facilitate use as a sinus and nasal spray. A spray dispenser such
as with, for instance, a pump spray, makes it very convenient to
apply the product externally and also provides a convenient and
efficient method for oral use and internal ingestion. By disbursing
the product upon spraying it in the mouth, such a spray facilitates
absorption of the formula into the blood system through the tissue
lining in the mouth. A spray dispenser also facilitates delivery of
the product to the lungs as one may inhale while spraying the
product towards the throat area. while inhaling. Because of the
existence of a weak complex of silver and the existence of
available free silver ions, along with the photoreactive qualities
of silver, packaging should preferably be in an opaque glass
container, in a stainless steel container, or in a polypropylene or
polyethylene plastic container. Ideally, dispensers should be made
of such materials as well.
[0037] Topically applying a gauze, cotton, sheer strip or other
type of bandage or fabric that has been saturated with the product
is another alternative for using the product.
[0038] The product can be used for humans as well as animals. When
the complexing agent is a nontoxic material, the product is safe
for children and pets. Thus, the invention has a wide range of
potential uses for both medical and veterinary applications.
[0039] The product can also be applied to surfaces for killing
germs thereon. For instance, it can be sprayed on counter tops,
cutting boards, toilet seats, doorknobs, telephone handsets, etc.
Upon contact with germ cells, the available free silver ions should
react with and kill the germ cell, causing another silver ion to be
decomplexed and released from the complexing agent and be made
available.
[0040] The invention may be utilized in both the prevention and the
treatment of disease.
[0041] Due to the efficient delivery of silver ions afforded by the
invention, an individual may ingest the product on a daily basis as
a preventative, achieving substantial levels of protection from
germs, while remaining within extremely safe limits of daily and
lifelong silver intake relative to the amount of silver contained
in the product in the preferred embodiment. Studies show that the
amount of silver in the average daily diet of adult Americans was
depleted by as much as 85% between the early half of the 20th
century and the latter part of that century. With the preferred
embodiment of the invention, an individual consuming a substantial
amount of the product on a daily basis in terms of potential health
benefits would, in fact, be consuming no more silver than that
amount which was depleted from the diets over that period of
time.
EXAMPLES
Example 1
[0042] Two and one-half liters of pure water were placed in a
5-gallon (1 9-liter functional capacity) carboy mounted on a
magnetic stirrer with a Teflon-coated magnetic stir bar placed
inside the carboy, turning on the stirrer at low speed, adding
6.7675 grams of citric acid anhydrous powder (reagent grade), 11.43
grams of potassium citrate monohydrate crystal (reagent grade), and
2.2450 grams of silver oxide powder (reagent grade), stirring at
low speed for approximately 45 minutes. Next more water was slowly
fed while continuing to stir at low speed for approximately an
additional 15 minutes and stopping the water input when the level
reaches approximately 8-9 liters. Then, the stir speed was turned
to high and stirring continued for approximately an additional 30
minutes, filling the carboy to approximately the 18-liter mark,
turning off the stirrer, opening the water input valve and stopping
the water input at precisely the 19-liter mark, turning the stirrer
back on to the high speed, and stirring for an additional 60
minutes.
Example 2
[0043] A 65-year old male developed conjunctivitis and obtained
relief within less than five hours upon administering two drops of
the solution of Example 1 in his eye.
Example 3
[0044] A sixteen-year old female had been suffering with acne for
three or four years. A dermatologist had been treating her
regularly to no avail. She applied six sprays of the solution of
Example 1 three times per day to her face for three days and
stopped using products from the dermatologist, and by the end of
the third day the skin on her face cleared up almost completely.
There was no dryness or redness any more.
Example 4
[0045] A 45-year old male had been diagnosed with lymphatic cancer
and after taking an oral dose of one teaspoon of the solution of
Example 1 per day for two months, tests showed that not a trace of
the disease remained.
Example 5
[0046] A 31-year old male and a 28-year old male who work together
in the same store had both come down with a full-blown flu. Both
took fifteen drops of the solution of Example 1 in an oral dose,
one time, and within a day-and-a-half both were completely free of
any further symptoms.
Example 6
[0047] A one-year old male was diagnosed with a blocked tear duct
in his left eye. Every day, he awoke with a green drainage that
continued through the day. Two physicians recommended surgery. The
boys mother administered only one drop of the solution of Example 1
in his eye each day for two days. The condition disappeared. Upon a
follow-up nine months later, the condition had not returned.
Example 7
[0048] A 53-year old woman burned the back of her hand on a
450-degree oven. The burn was approximately an inch-and-a-quarter
in diameter. After a week, it still had not begun to heal. The pain
was still so bad that she could barely move her hand. She put two
drops of the solution of Example 1 on it. By that same night, it
had completely scabbed over and the entire circumference of the
burn had already generated new tissue. The pain was completely gone
and she had regained complete movement of her hand. Within about
four more days of applying the invention, it was completely healed,
without any scarring.
Example 8
[0049] A 61-year old male had developed a urinary tract infection.
A urologist put him on sulfa drugs for twenty days. He suffered
through a week of constant nausea, at which point he threw out the
remaining pills. He then began to ingest 30 drops of the solution
of Example 1 per day, and after three days the infection was no
longer detectable.
Example 9
[0050] A forty-four-year old male developed abscesses surrounding
two wisdom teeth. Three oral surgeons told him the teeth had to
come out. He applied approximately one teaspoon of the solution of
Example 1 each to each of the two affected areas. By the next day,
the infections were undetectable and the pain was gone. A follow-up
eleven months later showed that it had not returned.
Example 10
[0051] A twenty-four-year old woman developed a vaginal infection.
The doctor's prescription didn't help after almost two weeks. She
then mixed one half-teaspoon of the solution of Example 1 in pure
water and used the mixture as a douche, and the discomfort
disappeared almost immediately and had not returned upon a
follow-up three weeks later.
* * * * *