U.S. patent application number 09/847788 was filed with the patent office on 2001-10-04 for hydrogels containing absorbable polyoxaamides.
Invention is credited to Bezwada, Rao S., Jamiolkowski, Dennis D..
Application Number | 20010026793 09/847788 |
Document ID | / |
Family ID | 24993338 |
Filed Date | 2001-10-04 |
United States Patent
Application |
20010026793 |
Kind Code |
A1 |
Jamiolkowski, Dennis D. ; et
al. |
October 4, 2001 |
Hydrogels containing absorbable polyoxaamides
Abstract
The present invention describes a crosslinked aliphatic
polyoxaamide polymer and blends thereof that may be used to produce
hydrogels, surgical devices such as catheters, molded devices, and
the like. The crosslinked aliphatic polyoxaamide of the present
invention are formed by crosslinking an aliphatic polyoxaamide
having a first divalent repeating unit of formula I:
[X--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)--
-] I and a second repeating unit selected from the group of
formulas consisting of: [--Y--R.sub.17--].sub.T, II
[--O--R.sub.5--C(O)--].sub.B, and III
([--O--R.sub.9--C(O)].sub.P--O--).sub.LG XI and combinations
thereof, --wherein X and Y are selected from the group consisting
of --O-- and --N(R)--, provided both X and Y are not both --O-- and
may be blended with a second polymer that is preferably
biocompatable.
Inventors: |
Jamiolkowski, Dennis D.;
(Long Valley, NJ) ; Bezwada, Rao S.; (Whitehouse
Station, NJ) |
Correspondence
Address: |
AUDLEY A. CIAMPORCERO JR.
JOHNSON & JOHNSON
ONE JOHNSON & JOHNSON PLAZA
NEW BRUNSWICK
NJ
08933-7003
US
|
Family ID: |
24993338 |
Appl. No.: |
09/847788 |
Filed: |
May 2, 2001 |
Related U.S. Patent Documents
|
|
|
|
|
|
Application
Number |
Filing Date |
Patent Number |
|
|
09847788 |
May 2, 2001 |
|
|
|
09365449 |
Aug 2, 1999 |
|
|
|
6251435 |
|
|
|
|
09365449 |
Aug 2, 1999 |
|
|
|
08744609 |
Nov 6, 1996 |
|
|
|
5962023 |
|
|
|
|
08744609 |
Nov 6, 1996 |
|
|
|
08611532 |
Mar 5, 1996 |
|
|
|
5597579 |
|
|
|
|
08611532 |
Mar 5, 1996 |
|
|
|
08598362 |
Feb 8, 1996 |
|
|
|
08598362 |
Feb 8, 1996 |
|
|
|
08554614 |
Nov 6, 1995 |
|
|
|
08554614 |
Nov 6, 1995 |
|
|
|
08399308 |
Mar 6, 1995 |
|
|
|
5464929 |
|
|
|
|
Current U.S.
Class: |
424/78.17 ;
528/67 |
Current CPC
Class: |
C08L 77/12 20130101;
C08L 77/12 20130101; A61L 31/041 20130101; A61L 27/18 20130101;
C08L 67/00 20130101; A61L 27/26 20130101; A61L 15/60 20130101; A61L
29/049 20130101; B33Y 80/00 20141201; C08G 69/44 20130101; C08L
67/00 20130101; A61K 47/34 20130101; A61L 15/26 20130101; A61L
29/145 20130101; A61L 17/105 20130101; A61L 29/06 20130101; C08L
67/025 20130101; A61L 27/52 20130101; C08G 63/664 20130101; A61L
31/06 20130101; A61L 15/60 20130101; C08G 69/40 20130101; A61L
15/225 20130101; A61L 15/26 20130101; A61L 31/041 20130101; A61L
15/225 20130101; A61L 31/06 20130101; C08G 63/672 20130101; A61L
29/049 20130101; A61L 29/06 20130101; C09D 167/00 20130101; C08L
77/12 20130101; A61L 27/26 20130101; A61L 31/06 20130101; C08L
77/12 20130101; A61K 9/204 20130101; A61L 31/145 20130101; C08L
67/025 20130101; A61L 15/225 20130101; A61L 27/18 20130101; A61L
27/18 20130101; C08L 2666/02 20130101; C09D 167/00 20130101; C08L
77/12 20130101; C08L 67/00 20130101; C08L 77/12 20130101; C08L
67/00 20130101; C08L 77/12 20130101; C08L 2666/02 20130101; C08L
77/12 20130101; C08L 77/12 20130101; C08L 67/00 20130101; C08L
77/12 20130101; C08L 2666/02 20130101; C08L 77/12 20130101; C08L
2666/02 20130101 |
Class at
Publication: |
424/78.17 ;
528/67 |
International
Class: |
A61K 031/785; C08G
018/70 |
Claims
We claim:
1. A crosslinked aliphatic polyoxaamides comprising a aliphatic
polyoxaamide having a first divalent repeating unit of formula I:
[X--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)-
--] I and a second repeating unit selected from the group of
formulas consisting of: [--Y--R.sub.17--].sub.T, II
[--O--R.sub.5--C(O)--].sub.B- , III
([--O--R.sub.9--C(O)].sub.P--O--).sub.LG XI and combinations
thereof, wherein X and Y are selected from the group consisting of
--O-- and --N(R)--, provided that X and Y cannot both be --O--; R,
R.sub.1 and R.sub.2 are independently selected from the group
consisting of hydrogen and an alkyl group containing 1 to 8 carbon
atoms; R.sub.3 is selected from the group consisting of an alkylene
unit and an oxyalkylene group of the following formula:
--[(CH.sub.2).sub.C--O--].sub.D--(CH.sub.2).sub.E-- - IV wherein C
is an integer in the range of from 2 to about 5, D is an integer in
the range of from 0 to about 2,000, and E is an integer in the
range of from about 2 to about 5, except when D is zero, in which
case E will be an integer in the range of from 2 to 12; R.sub.17 is
an alkylene unit containing from 2 to 8 carbon atoms which may have
substituted therein an internal ether oxygen, an internal
--N(R.sub.18)-- or an internal --C(O)--N(R.sub.21)--; T is an
integer in the range of from 1 to 2,000; R.sub.18 and R.sub.21 are
independently selected from the group consisting of hydrogen and an
alkyl group containing 1 to 8 carbon atoms; R.sub.5 and R.sub.9 are
selected from the group consisting of --C(R.sub.6)(R.sub.7)--,
--(CH.sub.2).sub.3--O--, --CH.sub.2--CH.sub.2--O- --CH.sub.2--,
--CR.sub.8H--CH.sub.2--, --(CH.sub.2).sub.5--,
--(CH.sub.2).sub.F--O--C(O)-- and
--(CH.sub.2).sub.K--C(O)--CH.sub.2--; R.sub.6 and R.sub.7 are
independently selected from the group consisting of hydrogen and an
alkyl containing from 1 to 8 carbon atoms; R.sub.8 is selected from
the group consisting of hydrogen and methyl; F and K are
independently selected integer in the range of from 2 to 6; B is an
integer in the range of from 1 to n such that the number average
molecular weight of formula III is less than about 200,000; P is an
integer in the range of from 1 to m such that the number average
molecular weight of formula XI is less than about 1,000,000; G
represents the residue minus from 1 to L hydrogen atoms from the
hydroxyl groups of an alcohol previously containing from 1 to about
200 hydroxyl groups; and L is an integer from about 1 to about 200;
wherein the aliphatic polyoxaamide has been crosslinked.
2. The crosslinked aliphatic polyoxaamides of claim 1 wherein the
number average molecular weight of formula III contained in the
polyoxaamide before crosslinking was less than 100,000.
3. The crosslinked aliphatic polyoxaamides of claim 1 wherein the
aliphatic polyoxamide before crosslinking had the formula:
[(--C(O)--C(R.sub.1)(R.sub.2)--O--R.sub.3--O--C(R.sub.1)(R.sub.2)--C(O)---
(Y--R.sub.17).sub.T--X).sub.S(C(O)--R.sub.5--O).sub.B].sub.W
wherein S is an integer in the range of from about 1 to about
10,000 and W is an integer in the range of from about 1 to about
1,000.
4. The crosslinked aliphatic polyoxaamides of claim 1 wherein the
aliphatic polyoxaamide before crosslinking had the formula:
[(--C(O)--C(R.sub.1)(R.sub.2)--O--R.sub.3--O--C(R.sub.1)(R.sub.2)--C(O)---
(Y--R.sub.17).sub.T--X).sub.S([--O--R.sub.9--C(O)].sub.P--O--).sub.LG].sub-
.W wherein S is an integer in the range of from about 1 to about
10,000 and W is an integer in the range of from about 1 to about
1,000.
5. A device containing crosslinked aliphatic polyoxaamides
comprising an aliphatic polyoxaamide having a first divalent
repeating unit of formula I:
[X--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C-
(O)--] I and a second repeating unit selected from the group of
formulas consisting of: [--Y--R.sub.17--].sub.T, II
[--O--R.sub.5--C(O)--].sub.B- , III
([--O--R.sub.9--C(O)].sub.P--O--).sub.LG XI and combinations
thereof, wherein X and Y are selected from the group consisting of
--O-- and --N(R)--, provided that X and Y cannot both be --O--; R,
R.sub.1 and R.sub.2 are independently selected from the group
consisting of hydrogen and an alkyl group containing 1 to 8 carbon
atoms; R.sub.3 is selected from the group consisting of an alkylene
unit and an oxyalkylene group of the following formula:
--[(CH.sub.2).sub.C--O--].sub.D--(CH.sub.2).sub.E-- - IV wherein C
is an integer in the range of from 2 to about 5, D is an integer in
the range of from 0 to about 2,000, and E is an integer in the
range of from about 2 to about 5, except when D is zero, in which
case E will be an integer in the range of from 2 to 12; R.sub.17 is
an alkylene unit containing from 2 to 8 carbon atoms which may have
substituted therein an internal ether oxygen, an internal
--N(R.sub.18)-- or an internal --C(O)--N(R.sub.21)--; T is an
integer in the range of from 1 to 2,000; R.sub.18 and R.sub.21 are
independently selected from the group consisting of hydrogen and an
alkyl group containing 1 to 8 carbon atoms; R.sub.5 and R.sub.9 are
selected from the group consisting of --C(R.sub.6)(R.sub.7)--,
--(CH.sub.2).sub.3--O--, --CH.sub.2--CH.sub.2--O- --CH.sub.2--,
--CR.sub.8H--CH.sub.2--, --(CH.sub.2).sub.5--,
--(CH.sub.2).sub.F--O--C(O)-- and
--(CH.sub.2).sub.K--C(O)--CH.sub.2--; R.sub.6 and R.sub.7 are
independently selected from the group consisting of hydrogen and an
alkyl containing from 1 to 8 carbon atoms; R.sub.8 is selected from
the group consisting of hydrogen and methyl; F and K are
independently selected integer in the range of from 2 to 6; B is an
integer in the range of from 1 to n such that the number average
molecular weight of formula III is less than about 200,000; P is an
integer in the range of from 1 to m such that the number average
molecular weight of formula XI is less than about 1,000,000; G
represents the residue minus from 1 to L hydrogen atoms from the
hydroxyl groups of an alcohol previously containing from 1 to about
200 hydroxyl groups; and L is an integer from about 1 to about 200;
wherein the aliphatic polyoxaamide has been crosslinked.
6. The device of claim 5 wherein the device is a surgical
device.
7. The device of claim 6 wherein the absorbable surgical device is
selected from the group consisting of burn dressings, hernia
patches, medicated dressings, fascial substitutes, gauze, fabrics,
sheets, felts, sponges, gauze bandages, arterial graft, bandages
for skin surfaces, suture knot clip, pins, clamps, screws, plates,
clips, staples, hooks, buttons, snaps, bone substitutes,
intrauterine devices, tubes, surgical instruments, vascular
implants, vascular supports, vertebral discs, and artificial
skin.
8. The device of claim 6 wherein the device is a filament.
9. The device of claim 8 wherein the filament is attached to a
needle.
10. A coated device having a coating containing a crosslinked
polyoxaamide comprising an aliphatic polyoxaamide having a first
divalent repeating unit of formula I:
[X--C(C)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.su-
b.1)(R.sub.2)--C(O)--] I and a second repeating unit selected from
the group of formulas consisting of: [--Y--R.sub.17--].sub.T, II
[--O--R.sub.5--C(O)--].sub.B, III
([--O--R.sub.9--C(O)].sub.P--O--).sub- .LG XI and combinations
thereof, wherein X and Y are selected from the group consisting of
--O-- and --N(R)--, provided that X and Y cannot both be --O--; R,
R.sub.1 and R.sub.2 are independently selected from the group
consisting of hydrogen and an alkyl group containing 1 to 8 carbon
atoms; R.sub.3 is selected from the group consisting of an alkylene
unit and an oxyalkylene group of the following formula:
--[(CH.sub.2).sub.C--O--].sub.D--(CH.sub.2).sub.E-- IV wherein C is
an integer in the range of from 2 to about 5, D is an integer in
the range of from 0 to about 2,000, and E is an integer in the
range of from about 2 to about 5, except when D is zero, in which
case E will be an integer in the range of from 2 to 12; R.sub.17 is
an alkylene unit containing from 2 to 8 carbon atoms which may have
substituted therein an internal ether oxygen, an internal
--N(R.sub.18)-- or an internal --C(O)--N(R.sub.21)--; T is an
integer in the range of from 1 to 2,000; R.sub.18 and R.sub.21 are
independently selected from the group consisting of hydrogen and an
alkyl group containing 1 to 8 carbon atoms; R.sub.5 and R.sub.9 are
selected from the group consisting of --C(R.sub.6)(R.sub.7)--,
--(CH.sub.2).sub.3--O--, --CH.sub.2--CH.sub.2--O- --CH.sub.2--,
--CR.sub.8H--CH.sub.2--, --(CH.sub.2).sub.5--,
--(CH.sub.2).sub.F--O--C(O)-- and
--(CH.sub.2).sub.K--C(O)--CH.sub.2--; R.sub.6 and R.sub.7 are
independently selected from the group consisting of hydrogen and an
alkyl containing from 1 to 8 carbon atoms; Ra is selected from the
group consisting of hydrogen and methyl; F and K are independently
selected integer in the range of from 2 to 6; B is an integer in
the range of from 1 to n such that the number average molecular
weight of formula III is less than about 200,000; P is an integer
in the range of from 1 to m such that the number average molecular
weight of formula XI is less than about 1,000,000; G represents the
residue minus from 1 to L hydrogen atoms from the hydroxyl groups
of an alcohol previously containing from 1 to about 200 hydroxyl
groups; and L is an integer from about 1 to about 200; wherein the
inherent viscosity of the aliphatic polyoxaamide is
crosslinked.
11. The coated device of claim 10 wherein the device is a
suture.
12. The coated device of claim 11 wherein the device is a
needle.
13. A drug delivery matrix comprising a drug and a crosslinked
aliphatic polyoxaamide wherein the crosslinked aliphatic
polyoxaamide is formed from an aliphatic polyoxaamide having a
first divalent repeating unit of formula I:
[X--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.s-
ub.2)--C(O)--] I and a second repeating unit selected from the
group of formulas consisting of: [--Y--R.sub.17--].sub.T, II
[--O--R.sub.5--C(O)--].sub.B, III
([--O--R.sub.9--C(O)].sub.P--O--).sub- .LG XI and combinations
thereof, wherein X and Y are selected from the group consisting of
--O-- and --N(R)--, provided that X and Y cannot both be --O--; R,
R.sub.1 and R.sub.2 are independently selected from the group
consisting of hydrogen and an alkyl group containing 1 to 8 carbon
atoms; R.sub.3 is selected from the group consisting of an alkylene
unit and an oxyalkylene group of the following formula:
--[(CH.sub.2).sub.C--O--].sub.D--(CH.sub.2).sub.E-- IV wherein C is
an integer in the range of from 2 to about 5, D is an integer in
the range of from 0 to about 2,000, and E is an integer in the
range of from about 2 to about 5, except when D is zero, in which
case E will be an integer in the range of from 2 to 12; R.sub.17 is
an alkylene unit containing from 2 to 8 carbon atoms which may have
substituted therein an internal ether oxygen, an internal
--N(R.sub.18)-- or an internal --C(O)--N(R.sub.21)--; T is an
integer in the range of from 1 to 2,000; R.sub.18 and R.sub.21 are
independently selected from the group consisting of hydrogen and an
alkyl group containing 1 to 8 carbon atoms; R.sub.5 and R.sub.9 are
selected from the group consisting of --C(R.sub.6)(R.sub.7)--,
--(CH.sub.2).sub.3--O--, --CH.sub.2--CH.sub.2--O- --CH.sub.2--,
--CR.sub.8H--CH.sub.2--, --(CH.sub.2).sub.5--,
--(CH.sub.2).sub.F--O--C(O)-- and
--(CH.sub.2).sub.K--C(O)--CH.sub.2--; R.sub.6 and R.sub.7 are
independently selected from the group consisting of hydrogen and an
alkyl containing from 1 to 8 carbon atoms; R.sub.8 is selected from
the group consisting of hydrogen and methyl; F and K are
independently selected integer in the range of from 2 to 6; B is an
integer in the range of from 1 to n such that the number average
number average molecular weight of formula III is less than about
200,000; P is an integer in the range of from 1 to m such that the
number average molecular weight of formula XI is less than about
1,000,000; G represents the residue minus from 1 to L hydrogen
atoms from the hydroxyl groups of an alcohol previously containing
from 1 to about 200 hydroxyl groups; and L is an integer from about
1 to about 200; wherein the aliphatic polyoxaamide is
crosslinked.
14. The device of claim 5 wherein the number average molecular
weight of formula XI in the aliphatic polyoxaamide before
crosslinking is less than 200,000.
15. The device of claim 5 wherein the aliphatic polyoxaamide before
crosslinking has the formula:
[(--C(O)--C(R.sub.1)(R.sub.2)--O--R.sub.3---
O--C(R.sub.1)(R.sub.2)--C(O)--(Y--R.sub.17).sub.T--X).sub.S(C(O)--R.sub.5--
-O).sub.B].sub.W wherein S is an integer in the range of from about
1 to about 10,000 and W is an integer in the range of from about 1
to about 1,000.
16. The device of claim 5 wherein the aliphatic polyoxaamide before
crosslinking has the formula:
[(--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)-
--O--C(R.sub.1)(R.sub.2)--C(O)--(Y--R.sub.17).sub.T--X).sub.S([--O--R.sub.-
9--C(O)].sub.P--O--).sub.LG].sub.W wherein S is an integer in the
range of from about 1 to about 10,000 and W is an integer in the
range of from about 1 to about 1,000.
17. The coated device of claim 10 wherein the aliphatic
polyoxaamide before crosslinking has the formula:
[--O--C(O)--C(R.sub.1)(R.sub.2)--O---
(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)--(O--R.sub.17).sub.T--].sub.N
wherein N is an integer in the range of from about 1 to about
10,000.
18. The coated device of claim 10 wherein the aliphatic
polyoxaamide before crosslinking has the formula:
[(--C(O)--C(R.sub.1)(R.sub.2)--O--R.-
sub.3--O--C(R.sub.1)(R.sub.2)--C(O)--(Y--R.sub.17).sub.T--X).sub.S(C(O)--R-
.sub.5--O).sub.B].sub.W wherein S is an integer in the range of
from about 1 to about 10,000 and W is an integer in the range of
from about 1 to about 1,000.
19. The coated device of claim 10 wherein the aliphatic
polyoxaamide before crosslinking has the formula:
[(--C(O)--C(R.sub.1)(R.sub.2)--O--R.-
sub.3--O--C(R.sub.1)(R.sub.2)--C(O)--(Y--R.sub.17).sub.T--X).sub.S([--O--R-
.sub.9--C(O)].sub.P--O--).sub.LG].sub.W wherein S is an integer in
the range of from about 1 to about 10,000 and W is an integer in
the range of from about 1 to about 1,000.
20. The drug delivery matrix of claim 13 wherein the aliphatic
polyoxaamide before crosslinking has the formula:
[--O--C(O)--C(R.sub.1)(-
R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)--(O--R.sub.17).sub.T--
-].sub.N wherein N is an integer in the range of from about 1 to
about 10,000.
21. The drug delivery matrix of claim 13 wherein the number average
weight of formula XI of the aliphatic polyoxaamide before
crosslinking is less than 200,0000.
22. The drug delivery matrix of claim 13 wherein the aliphatic
polyoxaamide before crosslinking has the formula:
(--C(O)--C(R.sub.1)(R.s-
ub.2)--O--R.sub.3--O--C(R.sub.1)(R.sub.2)--C(O)--(Y--R.sub.17).sub.T--X).s-
ub.S([--O--R.sub.9--C(O)].sub.P--O--).sub.LG].sub.W wherein S is an
integer in the range of from about 1 to about 10,000 and W is an
integer in the range of from about 1 to about 1,000.
23. The crosslinked aliphatic polyoxaamide of claim 1 wherein the
aliphatic polyoxaamide contains as a second repeat unit a lactone
derived repeating unit derived from lactone monomers selected from
the group consisting of glycolide, d-lactide, l-lactide,
meso-lactide, .epsilon.-caprolactone, p-dioxanone, trimethylene
carbonate, 1,4-dioxepan-2-one, 1,5-dioxepan-2-one and combinations
thereof.
24. The device of claim 5 wherein the aliphatic polyoxaamide
contains as a second repeat unit a lactone derived repeating unit
derived from lactone monomers selected from the group consisting of
glycolide, d-lactide, l-lactide, meso-lactide,
.epsilon.-caprolactone, p-dioxanone, trimethylene carbonate,
1,4-dioxepan-2-one, 1,5-dioxepan-2-one and combinations
thereof.
25. The device coated with a coating of claim 10 wherein the
aliphatic polyoxaamide in the coating contains as a second repeat
unit a lactone derived repeating unit derived from lactone monomers
selected from the group consisting of glycolide, d-lactide,
l-lactide, meso-lactide, .epsilon.-caprolactone, p-dioxanone,
trimethylene carbonate, 1,4-dioxepan-2-one, 1,5-dioxepan-2-one and
combinations thereof.
26. The drug delivery matrix of claim 13 wherein the aliphatic
polyoxaamide in the matrix contains as a second repeat unit a
lactone derived repeating unit derived from lactone monomers
selected from the group consisting of glycolide, d-lactide,
l-lactide, meso-lactide, .epsilon.-caprolactone, p-dioxanone,
trimethylene carbonate, 1,4-dioxepan-2-one, 1,5-dioxepan-2-one and
combinations thereof.
27. A polymer blend comprising a crosslinked aliphatic polyoxaamide
formed from an aliphatic polyoxaamide composed of a first divalent
repeating unit of formula I:
[X--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.su-
b.1)(R.sub.2)--C(O)--] I and a second repeating unit selected from
the group of formulas consisting of: [--Y--R.sub.17--].sub.T, II
[--O--R.sub.5--C(O)--].sub.B, III
([--O--R.sub.9--C(O)].sub.P--O--).sub- .LG XI and combinations
thereof, wherein X and Y are selected from the group consisting of
--O-- and --N(R)--, provided that X and Y cannot both be --O--; R,
R.sub.1 and R.sub.2 are independently selected from the group
consisting of hydrogen and an alkyl group containing 1 to 8 carbon
atoms; R.sub.3 is selected from the group consisting of an alkylene
unit and an oxyalkylene group of the following formula:
--[(CH.sub.2).sub.C--O--].sub.D--(CH.sub.2).sub.E-- IV wherein C is
an integer in the range of from 2 to about 5, D is an integer in
the range of from 0 to about 2,000, and E is an integer in the
range of from about 2 to about 5, except when D is zero, in which
case E will be an integer in the range of from 2 to 12; R.sub.17 is
an alkylene unit containing from 2 to 8 carbon atoms which may have
substituted therein an internal ether oxygen, an internal
--N(R.sub.18)-- or an internal --C(O)--N (R.sub.21)--; T is an
integer in the range of from 1 to 2,000; R.sub.18 and R.sub.21 are
independently selected from the group consisting of hydrogen and an
alkyl group containing 1 to 8 carbon atoms; R.sub.5 and R.sub.9 are
selected from the group consisting of --C(R.sub.6)(R.sub.7)--- ,
--(CH.sub.2).sub.3--O--, --CH.sub.2--CH.sub.2--O--CH.sub.2--,
--CR.sub.8H--CH.sub.2--, --(CH.sub.2).sub.5--,
--(CH.sub.2).sub.F--O--C(O- )-- and
--(CH.sub.2).sub.K--C(O)--CH.sub.2--; R.sub.6 and R.sub.7 are
independently selected from the group consisting of hydrogen and an
alkyl containing from 1 to 8 carbon atoms; R.sub.8 is selected from
the group consisting of hydrogen and methyl; F and K are
independently selected integer in the range of from 2 to 6; B is an
integer in the range of from 1 to n such that the number average
molecular weight of formula III is less than about 200,000; P is an
integer in the range of from 1 to m such that the number average
molecular weight of formula XI is less than about 1,000,000; G
represents the residue minus from 1 to L hydrogen atoms from the
hydroxyl groups of an alcohol previously containing from 1 to about
200 hydroxyl groups; and L is an integer from about 1 to about 200;
wherein said aliphatic polyoxaamide has been crosslinked and a
second polymer selected from the group consisting of homopolymer
and copolymer of lactone type polymers with the repeating units
described by formulas III and XI, aliphatic polyurethanes,
polyether polyurethanes, polyester polyurethanes, polyethylene
copolymers, polyamides, polyvinyl alcohols, poly(ethylene oxide),
polypropylene oxide, polyethylene glycol, polypropylene glycol,
polytetramethylene oxide, polyvinyl pyrrolidone, polyacrylamide,
poly(hydroxy ethyl acrylate), poly(hydroxyethyl methacrylate),
absorbable polyoxalates, absorbable polyanhydrides and combinations
thereof.
28. The polymer blend of claim 27 wherein the aliphatic
polyoxaamide before crosslinking has the formula:
[(--C(O)--C(R.sub.1)(R.sub.2)--O--R.-
sub.3--O--C(R.sub.1)(R.sub.2)--C(O)--(Y--R.sub.17).sub.T--X).sub.S(C(O)--R-
.sub.5--O).sub.B].sub.W wherein S is an integer in the range of
from about 1 to about 10,000 and W is an integer in the range of
from about 1 to about 1,000.
29. The polymer blend of claim 27 wherein the aliphatic
polyoxaamide before crosslinking has the formula:
[(--C(O)--C(R.sub.1)(R.sub.2)--O--R.-
sub.3--O--C(R.sub.1)(R.sub.2)--C(O)--(Y--R.sub.17).sub.T--X).sub.S([--O--R-
.sub.9--C(O)].sub.P--O--).sub.LG].sub.W wherein S is an integer in
the range of from about 1 to about 10,000 and W is an integer in
the range of from about 1 to about 1,000.
30. A device of claim 5 wherein the device additionally contains
blended with the crosslinked aliphatic poloxaamide a second polymer
selected from the group consisting of homopolymer and copolymer of
lactone type polymers with the repeating units described by
formulas III and XI, aliphatic polyurethanes, polyether
polyurethanes, polyester polyurethanes, polyethylene copolymers,
polyamides, polyvinyl alcohols, poly(ethylene oxide), polypropylene
oxide, polyethylene glycol, polypropylene glycol,
polytetramethylene oxide, polyvinyl pyrrolidone, polyacrylamide,
poly(hydroxy ethyl acrylate), poly(hydroxyethyl methacrylate)
absorbable polyoxalates, absorbable polyanhydrides and combinations
thereof.
31. The device of claim 30 wherein the device is a surgical
device.
32. The absorbable surgical device of claim 31 wherein the
absorbable surgical device is selected from the group consisting of
burn dressings, hernia patches, medicated dressings, fascial
substitutes, gauze, fabrics, sheets, felts, sponges, gauze
bandages, arterial graft, bandages for skin surfaces, suture knot
clip, pins, clamps, screws, plates, clips, staples, hooks, buttons,
snaps, bone substitutes, intrauterine devices, tubes, surgical
instruments, vascular implants, vascular supports, vertebral discs,
and artificial skin.
33. The absorbable surgical device of claim 31 wherein the device
is a catheter.
34. The catheter of claim 33 wherein the catheter contains an
elastomeric copolymer.
35. The catheter of claim 34 wherein the elastomeric copolymer is a
copolymer of .epsilon.-caprolactone and glycolide.
36. A coated device of claim 10 wherein coating additionally
contains a second polymer selected from the group consisting of
homopolymer and copolymer of lactone type polymers with the
repeating units described by formulas III and XI, aliphatic
polyurethanes, polyether polyurethanes, polyester polyurethanes,
polyethylene copolymers, polyamides, polyvinyl alcohols,
poly(ethylene oxide), polypropylene oxide, polyethylene glycol,
polypropylene glycol, polytetramethylene oxide, polyvinyl
pyrrolidone, polyacrylamide, poly(hydroxy ethyl acrylate),
poly(hydroxyethyl methacrylate) absorbable polyoxalates, absorbable
polyanhydrides and combinations thereof.
37. The drug delivery matrix of claim 13 wherein the matrix
additionally contains a second polymer selected from the group
consisting of homopolymer and copolymer of lactone type polymers
with the repeating units described by formulas III and XI,
aliphatic polyurethanes, polyether polyurethanes, polyester
polyurethanes, polyethylene copolymers, polyamides, polyvinyl
alcohols, poly(ethylene oxide), polypropylene oxide, polyethylene
glycol, polypropylene glycol, polytetramethylene oxide, polyvinyl
pyrrolidone, polyacrylamide, poly(hydroxy ethyl acrylate),
poly(hydroxyethyl methacrylate) absorbable polyoxalates, absorbable
polyanhydrides and combinations thereof.
38. The polymer blend of claim 27 wherein the polyoxaamide contains
as a second repeat unit a lactone derived repeating unit derived
from lactone monomers selected from the group consisting of
glycolide, d-lactide, l-lactide, meso-lactide,
.epsilon.-caprolactone, p-dioxanone, trimethylene carbonate,
1,4-dioxepan-2-one, 1,5-dioxepan-2-one and combinations
thereof.
39. The device of claim 30 wherein the aliphatic polyoxaamide
contains as a second repeat unit a lactone derived repeating unit
derived from lactone monomers selected from the group consisting of
glycolide, d-lactide, l-lactide, meso-lactide,
.epsilon.-caprolactone, p-dioxanone, trimethylene carbonate,
1,4-dioxepan-2-one, 1,5-dioxepan-2-one and combinations
thereof.
40. The coated device of claim 36 wherein the aliphatic
polyoxaamide in the coating contains as a second repeat unit a
lactone derived repeating unit derived from lactone monomers
selected from the group consisting of glycolide, d-lactide,
l-lactide, meso-lactide, .epsilon.-captolactone, p-dioxanone,
trimethylene carbonate, 1,4-dioxepan-2-one, 1,5-dioxepan-2-one and
combinations thereof.
41. The drug delivery matrix of claim 37 wherein the aliphatic
polyoxaamide in the matrix contains as a second repeat unit a
lactone derived repeating unit derived from lactone monomers
selected from the group consisting of glycolide, d-lactide,
l-lactide, meso-lactide, .epsilon.-caprolactone, p-dioxanone,
trimethylene carbonate, 1,4-dioxepan-2-one, 1,5-dioxepan-2-one and
combinations thereof.
42. A crosslinkable polyoxaamide prepolymer comprising a
polyoxaamide having a first divalent repeating unit of formula I:
[X--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)-
--] I and a second repeating unit selected from the group of
formulas consisting of: [--Y--R.sub.17--].sub.T, II
[--O--R.sub.5--C(O)--].sub.B- , III
([--O--R.sub.9--C(O)].sub.P--O--).sub.LG XI and combinations
thereof, wherein X and Y are selected from the group consisting of
--O-- and --N(R)--, provided that X and Y cannot both be --O--; R,
R.sub.1 and R.sub.2 are independently selected from the group
consisting of hydrogen and an alkyl group containing 1 to 8 carbon
atoms; R.sub.3 is selected from the group consisting of an alkylene
unit and an oxyalkylene group of the following formula:
--[(CH.sub.2).sub.C--O--].sub.D--(CH.sub.2).sub.E-- - IV wherein C
is an integer in the range of from 2 to about 5, D is an integer in
the range of from 0 to about 2,000, and E is an integer in the
range of from about 2 to about 5, except when D is zero, in which
case E will be an integer in the range of from 2 to 12; R.sub.17 is
an alkylene unit containing from 2 to 8 carbon atoms which may have
substituted therein an internal ether oxygen, an internal
--N(R.sub.18)-- or an internal --C(O)--N(R.sub.21)--; T is an
integer in the range of from 1 to 2,000; R.sub.18 and R.sub.21 are
independently selected from the group consisting of hydrogen and an
alkyl group containing 1 to 8 carbon atoms; R.sub.5 and R.sub.9 are
selected from the group consisting of --C(R.sub.6)(R.sub.7)--,
--(CH.sub.2).sub.3--O--, --CH.sub.2--CH.sub.2--O- --CH.sub.2--,
--CR.sub.8H--CH.sub.2--, --(CH.sub.2).sub.5--,
--(CH.sub.2).sub.F--O--C(O)-- and
--(CH.sub.2).sub.K--C(O)--CH.sub.2--; R.sub.6 and R.sub.7 are
independently selected from the group consisting of hydrogen and an
alkyl containing from 1 to 8 carbon atoms; R.sub.8 is selected from
the group consisting of hydrogen and methyl; F and K are
independently selected integer in the range of from 2 to 6; B is an
integer in the range of from 1 to n such that the number average
molecular weight of formula III is less than about 200,000; P is an
integer in the range of from 1 to m such that the number average
molecular weight of formula XI is less than about 1,000,000; G
represents the residue minus from 1 to L hydrogen atoms from the
hydroxyl groups of an alcohol previously containing from 1 to about
200 hydroxyl groups; and L is an integer from about 1 to about 200;
having at least one polymerizable region s chemically linked to the
polyoxaamide.
43. A hydrogel comprising water and a crosslinked polyoxaamide
prepolymer formed from a polyoxaamide having a first divalent
repeating unit of formula I:
[X--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.s-
ub.2)--C(O)--] I and a second repeating unit selected from the
group of formulas consisting of: [--Y--R.sub.17--].sub.T, II
[----R.sub.5--C(O)--].sub.B, III
([--O--R.sub.9--C(O)].sub.P--O--).sub.- LG XI and combinations
thereof, wherein X and Y are selected from the group consisting of
--O-- and --N(R)--, provided that X and Y cannot both be --O--; R,
R.sub.1 and R.sub.2 are independently selected from the group
consisting of hydrogen and an alkyl group containing 1 to 8 carbon
atoms; R.sub.3 is selected from the group consisting of an alkylene
unit and an oxyalkylene group of the following formula:
--[(CH.sub.2).sub.C--O--].sub.D--(CH.sub.2).sub.E-- IV wherein C is
an integer in the range of from 2 to about 5, D is an integer in
the range of from 0 to about 2,000, and E is an integer in the
range of from about 2 to about 5, except when D is zero, in which
case E will be an integer in the range of from 2 to 12; R.sub.17 is
an alkylene unit containing from 2 to 8 carbon atoms which may have
substituted therein an internal ether oxygen, an internal
--N(R.sub.18)-- or an internal --C(O)--N(R.sub.21)--; T is an
integer in the range of from 1 to 2,000; R.sub.18 and R.sub.21 are
independently selected from the group consisting of hydrogen and an
alkyl group containing 1 to 8 carbon atoms; R.sub.5 and R.sub.9 are
selected from the group consisting of --C(R.sub.6)(R.sub.7)--,
--(CH.sub.2).sub.3--O--, --CH.sub.2--CH.sub.2--O- --CH.sub.2--,
--CR.sub.8H--CH.sub.2--, --(CH.sub.2).sub.5--,
--(CH.sub.2).sub.F--O--C(O)-- and
--(CH.sub.2).sub.K--C(O)--CH.sub.2--; R.sub.6 and R.sub.7 are
independently selected from the group consisting of hydrogen and an
alkyl containing from 1 to 8 carbon atoms; R.sub.8 is selected from
the group consisting of hydrogen and methyl; F and K are
independently selected integer in the range of from 2 to 6; B is an
integer in the range of from 1 to n such that the number average
molecular weight of formula III is less than about 200,000; P is an
integer in the range of from 1 to m such that the number average
molecular weight of formula XI is less than about 1,000,000; G
represents the residue minus from 1 to L hydrogen atoms from the
hydroxyl groups of an alcohol previously containing from 1 to about
200 hydroxyl groups; and L is an integer from about 1 to about 200;
wherein the polyoxaamide is crosslinked.
Description
FIELD OF THE INVENTION
[0001] The present invention is a divisional of Ser. No. 08/744,609
which is a continuation-in-part of Ser. No. 08/611,532, filed Mar.
5, 1996, which is a continuation-in-part of Ser. No. 08/598,362,
filed Feb. 8, 1996, which is a continuation-in-part of Ser. No.
08/554,614, filed Nov. 6, 1995, which is a continuation-in-part of
Ser. No. 08/399,308, filed Mar. 6, 1995, now U.S. Pat. No.
5,464,929 (all hereby incorporated by reference herein) and relates
to a polymeric material and more particularly to absorbable
products made from polyoxaamides and blends thereof with other
polymers.
BACKGROUND OF THE INVENTION
[0002] Since Carothers early work in the 1920s and 1930s, aromatic
polyester particularly poly(ethylene terephthalate) have become the
most commercial important polyesters. The usefulness of these
polymers is intimately linked to the stiffening action of the
p-phenylene group in the polymer chain. The presence of the
p-phenylene group in the backbone of the polymer chain leads to
high melting points and good mechanical properties especially for
fibers, films and some molded products. In fact poly(ethylene
terephthalate) has become the polymer of choice for many common
consumer products, such as one and two liter soft drink
containers.
[0003] Several related polyester resins have been described in U.S.
Pat. Nos. 4,440,922, 4,552,948 and 4,963,641 which seek to improve
upon the properties of poly(ethylene terephthalate) by replacing
terephthalic acid with other related dicarboxylic acids which
contain phenylene groups. These polymers are generally designed to
reduce the gas permeability of aromatic polyesters.
[0004] Other aromatic polyesters have also been developed for
specialty applications such as radiation stable bioabsorbable
materials. U.S. Pat. Nos. 4,510,295, 4,546,152 and 4,689,424
describe radiation sterilizable aromatic polyesters which can be
used to make sutures and the like. These polymers like,
poly(ethylene terephthalate), have phenylene groups in the backbone
of the polymers.
[0005] However, less research has been reported on aliphatic
polyesters. After Carothers initial work on polyesters, aliphatic
polyesters were generally ignored because it was believed that
these materials had low melting points and high solubilities. The
only aliphatic polyesters that have been extensively studied are
polylactones such as polylacride, polyglycolide, poly(p-dioxanone)
and polycaprolactone. These aliphatic polylactones have been used
primarily for bioabsorbable surgical sutures and surgical devices
such as staples. Although polylactones have proven to be useful in
many applications they do not meet all the needs of the medical
community. For example films of polylactones do not readily
transmit water vapor, therefore, are not ideally suited for use as
bandages where the transmission of water vapor would be
desired.
[0006] Only recently has there been renewed interest in non-lactone
aliphatic polyesters. U.S. Pat. No. 5,349,028 describes the
formation of very simple aliphatic polyesters based on the reaction
of a dial with a dicarboxylic acid to form prepolymer chains that
are then coupled together. These polyesters are being promoted for
use in fibers and molded articles because these polyesters are
biodegradable after they are buried such as in a landfill. However,
these materials are not disclosed as being suitable for use in
surgical devices.
[0007] Thus it is an object of the present invention to provide
crosslinked aliphatic polyoxaamides (which includes
polyoxaesteramides) and blends thereof with other polymers that may
be used in surgical devices such as sutures, molded devices, drug
delivery matrices, coatings, lubricants and the like.
SUMMARY OF THE INVENTION
[0008] We have discovered a new class of synthetic crosslinked
polyoxaamides and blends thereof with other polymers that may be
used to produce a variety of useful products including surgical
devices such molded devices, drug delivery matrices, coatings,
lubricants and the like. The crosslinked polyoxaamide polymers of
the present invention are polymers comprising a first divalent
repeating unit of formula I:
[X--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)--
-] I
[0009] and a second repeating unit selected from the group of
formulas consisting of:
[--Y--R.sub.17--].sub.T, II
[--O--R.sub.5--C(O)--].sub.B, III
([--O--R.sub.9--C(O)].sub.P--O--).sub.LG XI
[0010] and combinations thereof, wherein X and Y are selected from
the group consisting of --O-- and --N(R)--, provided that X and Y
cannot both be --O--; R, R.sub.1 and R.sub.2 are independently
selected from the group consisting of hydrogen and an alkyl group
containing 1 to 8 carbon atoms; R.sub.3 is selected from the group
consisting of an alkylene unit and an oxyalkylene group of the
following formula:
--[(CH.sub.2).sub.C--O--].sub.D--(CH.sub.2) .sub.E-- IV
[0011] wherein C is an integer in the range of from 2 to about 5, D
is an integer in the range of from 0 to about 2,000, and E is an
integer in the range of from about 2 to about 5, except when D is
zero, in which case E will be an integer in the range of from 2 to
about 12; R.sub.17 is a alkylene unit containing from 2 to 8 carbon
atoms which may have substituted therein an internal ether oxygen,
an internal --N(R.sub.18)-- or an internal --C(O)--N(R.sub.21)--; T
is an integer in the range of from 1 to about 2,000 and preferably
is in the range of from 1 to about 1,000; R.sub.18 and R.sub.21 are
independently selected from the group consisting of hydrogen and an
alkyl group containing 1 to 8 carbon atoms; R.sub.5 and R.sub.9 are
selected from the group consisting of --C(R.sub.6)(R.sub.7)--,
--(CH.sub.2).sub.3--O--, --CH.sub.2--CH.sub.2--O- --CH.sub.2--,
--CR.sub.8H--CH.sub.2--, --(CH.sub.2).sub.5--,
--(CH.sub.2).sub.F--O--C(O)-- and
--(CH.sub.2).sub.K--C(O)--CH.sub.2--; R.sub.6 and R.sub.7 are
independently selected from the group consisting of hydrogen and an
alkyl containing from 1 to 8 carbon atoms; R.sub.8 is selected from
the group consisting of hydrogen and methyl; F and K are
independently selected integer in the range of from 2 to 6; B is an
integer in the range of from 1 to n such that the number average
molecular weight of formula III is less than about 200,000,
preferably less than 100,000 and more preferably less than 40,000;
P is an integer in the range of from 1 to m such that the number
average molecular weight of formula XI is less than about
1,000,000, preferably less than 200,000 and more preferably less
than 40,000; G represents the residue minus from 1 to L hydrogen
atoms from the hydroxyl groups of an alcohol previously containing
from 1 to about 200 hydroxyl groups; and L is an integer from about
1 to about 200; which have been crosslinked.
[0012] Additionally, the present invention describes a prepolymer
comprising an aliphatic polyoxaamide chemically linked to at least
one polymerizable region.
DETAILED DESCRIPTION OF THE INVENTION
[0013] The aliphatic polyoxaamides (which also includes
polyoxaesteramides that are within the scope of the present
invention) of the present invention are the reaction product of 1)
a.pi. aliphatic polyoxydicarboxylic acid and a diamine or amino
alcohol optionally containing one of the following compounds: a
diol (or polydiol), a lactone (or lactone oligomer), a coupling
agent or combination thereof.
[0014] Suitable aliphatic alpha-oxydicarboxylic acids (or
oxadicarboxylic acids) for use in the present invention generally
have the following formula:
HO--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O)--
-OH V
[0015] wherein R, R.sub.1 and R.sub.2 are independently selected
from the group consisting of hydrogen and an alkyl group containing
from 1 to 8 carbon atoms and R.sub.3 is an alkylene containing from
2 to 12 carbon atoms or is an oxyalkylene group of the following
formula:
--[(CH.sub.2).sub.C--O--].sub.D--(CH.sub.2).sub.E-- IV
[0016] wherein C is an integer in the range of from about 2 to
about 5, D is an integer in the range of from 0 to about 2,000 and
preferably 1 to about 12, and E is an integer in the range of from
about 2 to about 5, except when D is zero, in which case E will be
an integer in the range of from 2 to 12. These aliphatic
alpha-oxydicarboxylic acids may be formed by reacting a diol or
polydiol with an alpha-halocarboxylic acid such bromoacetic acid or
chloroacetic acid under suitable conditions.
[0017] In some instances the corresponding mono or diester of the
aliphatic alpha-oxydicarboxylic acids of formula V may be used.
[0018] Suitable amino alcohols, diamines, diols or polydiols for
use in the present invention have repeating units with up to 8
carbon atoms having the formulas:
H[--(N(R.sub.12)--R.sub.13--).sub.U]OH VIA
H[--(N(R.sub.14)--R.sub.15--).sub.VN(R.sub.16) VIB
H[--(O--R.sub.4--).sub.A]OH, VIC
H[--(O--R.sub.19--).sub.Z]N(R.sub.20)H, VID
[0019] wherein R.sub.13, R.sub.15, R.sub.4 and R.sub.19 are
independently alkylene units containing from 2 to 8 methylene units
which may have substituted therein an internal ether oxygen, an
internal --N(R.sub.18)-- or internal --C(O)--N(R.sub.21)--;
R.sub.18 and R.sub.21 are independently selected from the group
consisting of hydrogen and an alkyl group containing 1 to 8 carbon
atoms; R.sub.12, R.sub.14, R.sub.16 and R.sub.20 are independently
selected from the group consisting of hydrogen, alkyl group
containing from 1 to 8 carbon atoms and mixtures thereof; A, U, V
and Z are independently integers in the range of from 1 to about
2,000 and preferably from 1 to 1,000. Examples of suitable amino
alcohols include amino alcohols selected from the group consisting
of ethanol amine, isopropanol amine, 3-amino-1-propanol,
4-amino-1-butanol, 4-amino-2-butanol, 2-atnino-1-butanol and
2-(2-aminoethoxy)ethanol. Examples of suitable diamines include
diamines selected from the group consisting of ethylene diamine,
1,2-diaminopropane, 1,3-diaminopropane, 1,4-diaminobutane,
1,4-diaminocyclohexane and 1,5-diamino-3-oxapentane. Examples of
suitable diols include diols selected from the group consisting of
1,2-ethanediol (ethylene glycol), 1,2-propanediol (propylene
glycol), 1,3-propanediol, 1,4-butanediol, 1,5-pentanediol,
1,3-cyclopentanediol, 1,6-hexanediol, 1,4-cyclohexanediol,
1,8-octanediol and combinations thereof. Examples of preferred
polydiols include polydiols selected from the group consisting of
polyethylene glycol (H[--O--CH.sub.2--CH.sub.2--].sub.AOH) and
polypropylene glycol
(H[--O--CH.sub.2--CH(CH.sub.3)--].sub.AOH).
[0020] The polymer produced by reacting the aliphatic
dioxacarboxylic acid with the amino alcohols discussed above should
provide a polymer generally having the formula:
[--O--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.sub.2)--C(O-
)--(N(R.sub.12)--R.sub.13).sub.U--].sub.J VIIA
[0021] wherein R.sub.1, R.sub.2, R.sub.3, R.sub.12, R.sub.13 and U
are as described above; and J is an integer in the range of from
about 1 to about 10,000 and preferably is in the range of from
about 10 to about 1,000 and most preferably in the range of from
about 50 to about 200.
[0022] The polymer produced by reacting the aliphatic
dioxacarboxylic acid with the diamine discussed above should
provide a polymer generally having the formula:
[--N(R.sub.16)--C(O)--C(R.sub.1)(R.sub.2)--O--(R.sub.3)--O--C(R.sub.1)(R.s-
ub.2)--C(O)--(N(R.sub.14)--R.sub.15).sub.V--].sub.J VIIB
[0023] wherein R.sub.1, R.sub.2, R.sub.3, R.sub.14, R.sub.15,
R.sub.16 V and J are as described above.
[0024] The polymer produced by reacting the aliphatic
dioxacarboxylic acid with a mixture of aminoalcohols, diols and
diamines discussed above should provide a polymer generally having
end groups that may be active amines or hydroxyl groups.
[0025] Suitable lactone monomers that may be used in the present
invention generally have the formula:
O--R.sub.5--C(O) VIII
[0026] These lactone monomers (or equivalent acids if any) may be
polymerized to provide polymers of the following general
structures:
H[--O--R.sub.5--C(O)--].sub.BOH IX
(H[--O--R.sub.9--C(O)].sub.P--O--).sub.LG X
[0027] wherein R.sub.5 and R.sub.9 are independently selected from
the group consisting of --C(R.sub.6)(R.sub.7)--,
--(CH.sub.2).sub.3--O--, --CH.sub.2--CH.sub.2--O--CH.sub.2--,
--CR.sub.8H--CH.sub.2--, --(CH.sub.2).sub.5--,
--(CH.sub.2).sub.F--O--C(O)-- and
--(CH.sub.2).sub.K--C(O)--CH.sub.2--; R.sub.6 and R.sub.7 are
independently selected from the group consisting of hydrogen and an
alkyl containing from 1 to 8 carbon atoms; R.sub.8 is selected from
the group consisting of hydrogen and methyl; F and K are integers
in the range of from 2 to 6; B is an integer in the range of from 1
to n such that the number average molecular weight of formula IX is
less than about 200,000, preferably less than about 100,000, more
preferably less than about 40,000 and most preferably less than
20,000; P is an integer in the range of from 1 to m such that the
number average molecular weight of formula X is less than about
1,000,000, preferably less than about 200,000, more preferably less
than about 40,000 and most preferably less than 20,000; G
represents the residue minus from 1 to L hydrogen atoms from the
hydroxyl groups of an alcohol previously containing from 1 to about
200 hydroxyl groups; and L is an integer from about 1 to about 200.
Preferably G will be the residue of a dihydroxy alcohol minus both
hydroxyl groups. Suitable lactone-derived repeating units may be
generated from the following monomers include but are not limited
to lactone monomers selected from the group consisting of
glycolide, d-lactide, l-lactide, meso-lactide,
.epsilon.-caprolactone, p-dioxanone, trimethylene carbonate,
1,4-dioxepan-2-one, 1,5-dioxepan-2-one and combinations
thereof.
[0028] The polymer formed by reacting the above described amino
alcohols, diamines, and diol (or polydiol) VI with the appropriate
aliphatic oxadicarboxylic acid or aliphatic polyoxadicarboxylic
acid V may also be copolymerized in a secondary ring-opening
polymerization with the lactone monomers XIII or in a condensation
copolymerization with the lactone oligomers IX or X, described
above to form a polymer generally of the formula:
[(--C(O)--C(R.sub.1)(R.sub.2)--O--R.sub.3--O--C(R.sub.1)(R.sub.2)--C(O)--(-
Y--R.sub.4).sub.A--X).sub.S--(C(O)--R.sub.5--O).sub.B].sub.W
XII
or
[(X--(R.sub.4--Y).sub.A--C(O)--C(R.sub.1)(R.sub.2)--O--R.sub.3--O--C(R.sub-
.1)(R.sub.2)--C(O)).sub.S--([--O--R.sub.9--C(O)].sub.P--O--).sub.LG].sub.W
XIII
[0029] wherein X and Y are selected from the group consisting of
--O-- and N(R), provided that X and Y cannot both be --O--; and S
is an integer in the range of from about 1 to about 10,000 and is
preferably an integer in the range of from about 1 to about 1,000
and W is an integer in the range of from about 1 to about 1,000.
These polymers may be made in the form of random copolymers or
block copolymers. To the compounds described above there may be
added a coupling agent selected from the group consisting of
trifunctional or tetrafunctional polyols, oxycarboxylic acids, and
polybasic carboxylic acids (or acid anhydrides thereof). The
addition of the coupling agents causes the branching of long
chains, which can impart desirable properties in the molten state
to the polyester prepolymer. Examples of suitable polyfunctional
coupling agents include trimethylol propane, glycerin,
pentaerythritol, malic acid, citric acid, tartaric acid, trimesic
acid, propane tricarboxylic acid, cyclopentane tetracarboxylic
anhydride, triethanol amine and combinations thereof.
[0030] The amount of coupling agent to be added before gelation
occurs is a function of the type of coupling agent used and the
polymerization conditions of the polyoxaamide or molecular weight
of the prepolymer to which it is added. Generally in the range of
from about 0.1 to about 10 mole percent of a trifunctional or a
tetrafunctional coupling agent may be added based on the moles of
aliphatic polyoxaamide polymers present or anticipated from the
synthesis.
[0031] The preparation of the aliphatic polyoxaamides (which also
includes polyoxaesteramides) are preferably polymerizations
performed under melt polycondensation conditions at elevated
temperatures. At times it may be preferably to add a catalyst such
as an organometallic compound. Preferred organometallic catalysts
are tin-based catalysts e.g. stannous octoate. The catalyst will
preferably be present in the mixture at a mole ratio of hydroxy
groups, aliphatic polyoxadicarboxylic acid and optionally lactone
monomer to catalyst will be in the range of from about 5,000 to
about 80,000/1. The reaction is preferably performed at a
temperature no less than about 120.degree. C. under reduced
pressure.
[0032] Higher polymerization temperatures may lead to further
increases in the molecular weight of the copolymer, which may be
desirable for numerous applications. The exact reaction conditions
chosen will depend on numerous factors, including the properties of
the polymer desired, the viscosity of the reaction mixture, and the
glass transition temperature and softening temperature of the
polymer. The preferred reaction conditions of temperature, time and
pressure can be readily determined by assessing these and other
factors.
[0033] Generally, the reaction mixture will be maintained at about
220.degree. C. The polymerization reaction can be allowed to
proceed at this temperature until the desired molecular weight and
percent conversion is achieved for the copolymer, which will
typically take about 15 minutes to 24 hours. Increasing the
reaction temperature generally decreases the reaction time needed
to achieve a particular molecular weight, but may also increase the
extent of side reactions. We have found that reaction at about
220.degree. C. to be generally suitable.
[0034] An alternative method of preparing the aliphatic
polyoxaamides involves the formation of a salt between the
aliphatic alpha-oxydicarboxylic acids of the present invention and
multifunctional amines(i.e. diamines) with susequent plymerization
of the salt.
[0035] In another embodiment, aliphatic polyoxaamide copolymers can
be prepared by forming an aliphatic polyoxaamide prepolymer
polymerized under melt polycondensation conditions, then adding at
least one lactone monomer or lactone prepolymer. The mixture would
then be subjected to the desired conditions of temperature and time
to copolymerize the prepolymer with the lactone monomers. If a
lactone prepolymer is used, a polycondensation reaction can be used
to increase the molecular weight.
[0036] The molecular weight of the prepolymer as well as its
composition can be varied depending on the desired characteristic
which the prepolymer is to impart to the copolymer. However, it is
preferred that the aliphatic polyoxaamide prepolymers from which
the copolymer is prepared have a molecular weight that provides an
inherent viscosity between about 0.2 to about 2.0 deciliters per
gram (dl/g) as measured in a 0.1 g/dl solution of
hexafluoroisopropanol at 25.degree. C. Those skilled in the art
will recognize that the aliphatic polyoxaamide prepolymers
described herein can also be made from mixtures of more than one
diol, amino alcohol, or dioxacarboxylic acid.
[0037] One of the beneficial properties of the aliphatic
polyoxaamide made by the process of this invention is that the
ester linkages are hydrolytically unstable, and therefore the
polymer is bioabsorbable because it readily breaks down into small
segments when exposed to moist bodily tissue. In this regard, while
it is envisioned that co-reactants could be incorporated into the
reaction mixture of the aliphatic dioxacarboxylic acid and the diol
for the formation of the aliphatic polyoxaamide prepolymer, it is
preferable that the reaction mixture does not contain a
concentration of any co-reactant which would render the
subsequently prepared polymer nonabsorbable. Preferably, the
reaction mixture is substantially free of any such co-reactants if
the resulting polymer is rendered nonabsorbable.
[0038] These aliphatic polyoxaamides of the present invention and
those described in Ser. No. 08/399,308, filed Mar. 6, 1995 and
assigned to Ethicon, now U.S. Pat. No. 5,464,929 may be blended
together with other homopolymers copolymers and graft copolymers to
impart new properties to the material formed by the blend. The
other polymers which the aliphatic polyoxaamides may be blended
with include but are not limited to homopolymer and copolymer of
lactone type polymers with the repeating units described by Formula
VIII, polyesters (such as adipates) aliphatic polyurethanes,
polyether polyurethanes, polyester polyurethanes, polyethylene
copolymers (such as ethylene-vinyl acetate copolymers and ethylene
ethyl acrylate copolymers), polyamides, polyvinyl alcohols,
poly(ethylene oxide), polypropylene oxide, polyethylene glycol,
polypropylene glycol, polytetramethylene oxide, polyvinyl
pyrrolidone, polyacrylamide, poly(hydroxy ethyl acrylate),
poly(hydroxyethyl methacrylate) absorbable polyoxalates, absorbable
polyanhydrides and combinations thereof. The copolymers (i.e.
containing two or more repeating units) including random, block and
segmented copolymers. Suitable lactone-derived repeating units may
be generated from the following monomers include but are not
limited to lactone monomers selected from the group consisting of
glycolide, d-lactide, l-lactide, meso-lactide,
.epsilon.-caprolactone, p-dioxanone, trimethylene carbonate,
1,4-dioxepan-2-one, 1,5-dioxepan-2-one and combinations thereof.
The blends may contain about 1 weight percent to about 99 weight
percent of the aliphatic polyoxaamides.
[0039] For some applications it may be desirable to add additional
ingredients such as stabilizers, antioxidants radiopacifiers,
fillers or the like.
[0040] The aliphatic polyoxaamide and other polymers may be blended
using conventional mixing processes known in the art. For example a
blend- can be prepared using a two-roll mill, an internal mixer
(such as a Brabender or Banbury mixer), an extruder (such as a twin
screw extruder) or the like.
[0041] The polymers and blends of this invention can be melt
processed bv numerous methods to prepare a vast array of useful
devices. These polymer and blends can be injection or compression
molded to make implantable medical and surgical devices, especially
wound closure devices. The preferred wound closure devices are
surgical clips, staples and sutures.
[0042] Alternatively, the polymers and blends can be extruded to
prepare fibers. The filaments thus produced may be fabricated into
sutures or ligatures, attached to surgical needles, packaged, and
sterilized by known techniques. The polymers of the present
invention may be spun as multifilament yarn and woven or knitted to
form sponges or gauze, (or non-woven sheets may be prepared) or
used in conjunction with other molded compressive structures as
prosthetic devices within the body of a human or animal where it is
desirable that the structure have high tensile strength and
desirable levels of compliance and/or ductility. Useful embodiments
include tubes, including branched tubes, for artery, vein or
intestinal repair, nerve splicing, tendon splicing, sheets for
typing up and supporting damaged surface abrasions, particularly
major abrasions, or areas where the skin and underlying tissues are
damaged or surgically removed.
[0043] Additionally, the polymers and blends can be molded to form
films which, when sterilized, are useful as adhesion prevention
barriers. Another alternative processing technique for the polymers
and blends of this invention includes solvent casting, particularly
for those applications where a drug delivery matrix is desired.
[0044] In more detail, the surgical and medical uses of the
filaments, films, and molded articles of the present invention
include, but are not necessarily limited to:
[0045] Knitted products, woven or non-woven, and molded products
including:
[0046] a. burn dressings
[0047] b. hernia patches
[0048] c. medicated dressings
[0049] d. fascial substitutes
[0050] e.gauze, fabric, sheet, felt or sponge for liver
hemostasis
[0051] f. gauze bandages
[0052] g. arterial graft or substitutes
[0053] h. bandages for skin surfaces
[0054] i. suture knot clip
[0055] j. orthopedic pins, clamps, screws, and plates
[0056] k. clips (e.g.,for vena cava)
[0057] l. staples
[0058] m. hooks, buttons, and snaps
[0059] n. bone substitutes (e.g., mandible prosthesis)
[0060] o. intrauterine devices (e.g.,spermicidal devices)
[0061] p. draining or testing tubes or capillaries
[0062] q. surgical instruments
[0063] r. vascular implants or supports
[0064] s. vertebral discs
[0065] t. extracorporeal tubing for kidney and heart-lung
machines
[0066] u. artificial skin and others
[0067] v. catheters (including, but not limited to, the catheters
described in U.S. Pat. No. 4,883,699 which is hereby incorporated
by reference)
[0068] w. scaffoldings and the like for tissue engineering
applications.
[0069] In another embodiment, the polymers and blends (which
includes prepolymers and suitable crosslinked polymers) can be used
to coat a surface of a surgical article to enhance the lubricity of
the coated surface. The polymer blends may be applied as a coating
using conventional techniques. For example, the polymers and blends
may be solubilized in a dilute solution of a volatile organic
solvent, e.g. acetone, methanol, ethyl acetate or toluene, and then
the article can be immersed in the solution to coat its surface.
Once the surface is coated, the surgical article can be removed
from the solution where it can be dried at room or elevated
temperatures until the solvent and any residual reactants are
removed.
[0070] For use in coating applications the polymers and blends
should exhibit an inherent viscosity (in the case of crosslinked
polymers before crosslinking), as measured in a 0.1 gram per
deciliter (g/dl) of hexafluoroisopropanol (HFIP), between about
0.05 to about 2.0 dl/g, preferably about 0.10 to about 0.80 dl/g.
If the final inherent viscosity were less than about 0.05 dl/g,
then the polymers and blends may not have the integrity necessary
for the preparation of films or coatings for the surfaces of
various surgical and medical articles. On the other hand, although
it is possible to use polymers and blends with an inherent
viscosity (for crosslinkable polymers measured before crosslinking)
greater than about 2.0 dl/g, it may be exceedingly difficult to do
so.
[0071] Although it is contemplated that numerous surgical articles
(including but not limited to endoscopic instruments) can be coated
with the polymers and blends of this invention to improve the
surface properties of the article, the preferred surgical articles
are surgical sutures and needles. The most preferred surgical
article is a suture, most preferably attached to a needle.
Preferably, the suture is a synthetic absorbable suture. These
sutures are derived, for example, from homopolymers and copolymers
of lactone monomers such as glycolide, lactide,
.epsilon.-caprolactone, 1,4-dioxanone, and trimethylene carbonate.
The preferred suture is a braided multifilament suture composed of
polyglycolide or poly (glycolide-co-lactide)
[0072] The amount of polymer or blend to be applied on the surface
of a braided suture can be readily determined empirically, and will
depend on the particular copolymer and suture chosen. Ideally, the
amount of polymer blend applied to the surface of the suture may
range from about 0.5 to about 30 percent of the weight of the
coated suture, more preferably from about 1.0 to about 20 weight
percent, most preferably from 1 to about 5 weight percent. If the
amount of coating on the suture were greater than about 30 weight
percent, then it may increase the risk that the coating may flake
off when the suture is passed through tissue.
[0073] Sutures coated with the polymers and blends of this
invention are desirable because they have a more slippery feel,
thus making it easier for the surgeon to slide a knot down the
suture to the site of surgical trauma. In addition, the suture can
be passed more easily through body tissue thus reducing tissue
trauma. These advantages are exhibited in comparison to sutures
which do not have their surfaces coated with the polymers and
blends of this invention.
[0074] In another embodiment of the present invention when the
article is a surgical needle, the amount of coating applied to the
surface of the article is an amount which creates a layer with a
thickness ranging preferably between about 2 to about 20 microns on
the needle, more preferably about 4 to about 8 microns. If the
amount of coating on the needle were such that the thickness of the
coating layer was greater than about 20 microns, or if the
thickness was less than about 2 microns, then the desired
performance of the needle as it is passed through tissue may not be
achieved.
[0075] In yet another embodiment of the present invention, the
polymers and blends can be used as a pharmaceutical carrier in a
drug delivery matrix. To form this matrix the polymers and blends
would be mixed with a therapeutic agent to form the matrix. The
variety of different therapeutic agents which can be used in
conjunction with the polymers and blends of the present invention
is vast. In general, therapeutic agents which may be administered
via the pharmaceutical compositions of the invention include,
without limitation: antiinfectives such as antibiotics and
antiviral agents; analgesics and analgesic combinations; anorexics;
antihelmintics; antiarthritics; antiasthmatic agents;
anticonvulsants; antidepressants; antidiuretic agents;
antidiarrheals; antihistamines; antiinflammatory agents;
antimigraine preparations; antinauseants; antineoplastics;
antiparkinsonism drugs; antipruritics; antipsychotics;
antipyretics, antispasmodics; anticholinergics; sympathomimetics;
xanthine derivatives; cardiovascular preparations including calcium
channel blockers and beta-blockers such as pindolol and
antiarrhythmics; antihypertensives; diuretics; vasodilators
including general coronary, peripheral and cerebral; central
nervous system stimulants; cough and cold preparations, including
decongestants; hormones such as estradiol and other steroids,
including corticosteroids; hypnotics; immunosuppressives; muscle
relaxants; parasympatholytics; psychostimulants; sedatives; and
tranquilizers; and naturally derived or genetically engineered
proteins, polysaccharides, glycoproteins, or lipoproteins.
[0076] The drug delivery matrix may be administered in any suitable
dosage form such as oral, parenteral, a subcutaneously as an
implant, vaginally or as a suppository. Matrix formulations
containing the polymer blends may be formulated by mixing one or
more therapeutic agents with the blends. The therapeutic agent, may
be present as a liquid, a finely divided solid, or any other
appropriate physical form. Typically, but optionally, the matrix
will include one or more additives, e.g., nontoxic auxiliary
substances such as diluents, carriers, excipients, stabilizers or
the like. Other suitable additives may be formulated with the
polymers and blends and pharmaceutically active agent or compound,
however, if water is to be used it should be added immediately
before administration.
[0077] The amount of therapeutic agent will be dependent upon the
particular drug employed and medical condition being treated.
Typically, the amount of drug represents about 0.001% to about 70%,
more typically about 0.001% to about 50%, most typically about
0.001% to about 20% by weight of the matrix.
[0078] The quantity and type of polymers and blends incorporated
into the parenteral will vary depending on the release profile
desired and the amount of drug employed. The product may contain
blends of polymers of different molecular weights to provide the
desired release profile or consistency to a given formulation.
[0079] The polymers and blends, upon contact with body fluids
including blood or the like, undergoes gradual degradation (mainly
through hydrolysis) with concomitant release of the dispersed drug
for a sustained or extended period (as compared to the release from
an isotonic saline solution). This can result in prolonged delivery
(over, say 1 to 2,000 hours, preferably 2 to 800 hours) of
effective amounts (say, 0.0001 mg/kg/hour to 10 mg/kg/hour) of the
drug. This dosage form can be administered as is necessary
depending on the subject being treated, the severity of the
affliction, the judgment of the prescribing physician, and the
like.
[0080] Individual formulations of drugs and polyoxaamide containing
polymers may be tested in appropriate in vitro and in vivo models
to achieve the desired drug release profiles. For example, a drug
could be formulated with a polyoxaamide and orally administered to
an animal. The drug release profile could then be monitored by
appropriate means such as, by taking blood samples at specific
times and assaying the samples for drug concentration. Following
this or similar procedures, those skilled in the art will be able
to formulate a variety of formulations.
[0081] The polymers (including copolymers) and blends of the
present invention can be crosslinked to affect mechanical
properties. Crosslinking may either be chemically or physical.
Chemically crosslinked polymer chains are connected by covalent
bonds, which can be formed by reactive groups contained on the
polymers, the addition of crosslinking enhancers and/or irradiation
(such as gamma-irradiation). Physical crosslinking on the other
hand connects the polymer chains through non-covalent bonds such as
van der Waals interactions, hydrogen bonding or hydrophobic
interactions. In particular, crosslinking can be used to control
the water swellability of said invention.
[0082] In one embodiment, Formulas VII A and VII B may be endcapped
with one or more crosslinkable regions.
[0083] Similarly, Formula XII and XIII may be crosslinked by
attaching one or more polymerizable regions to an amine group.
[0084] The polymerizable regions are preferably polymerizable by
photoinitiation by free radical generation, most preferably in the
visible or long wavelength ultraviolet radiation. The preferred
polymerizable regions are acrylates, diacrylates, oligoacrylates,
methacrylates, dimethacrylates, oligomethoacrylates, or other
biologically acceptable photopolymerizable groups.
[0085] Other initiation chemistries may be used besides
photoinitiation. These include, for example, water and amine
initiation schemes with isocyanate or isothiocyanate containing
macromers used as the polymerizable regions.
[0086] Useful photoinitiaors are those which can be used to
initiate by free radical generation polymerization of the macromers
without cytotoxicity and within a short time frame, minutes at most
and most preferably seconds. Preferred dyes as initiators of choice
for long wave length ultraviolet (LWUV) or visible light initiation
are ethyl eosin, 2,2-dimethoxy-2-phenyl acetophenone, other
acetophenone derivatives, and camphorquinone. Crosslinking and
polymerization may be initiated among macromers by a light
activated free-radical polymerization initiator such as
2,2-dimethoxy-2-phenyl acetophenone, other acetophenone
derivatives, and camphorquinone. In other cases, crosslinking and
polymerization are initiated among macromers by a light-activated
free-radical polymerization initiator such as
2,2-dimethoxy-2-phenylacetophenone or a combination of ethyl eosin
(10-.sup.4 to 10-.sup.2M) and triethanol amine (0.001 to 0.1M), for
example.
[0087] The choice of the photoinitiator is largely dependent on the
photopolymerizable regions. Although we do not wish to be limited
by scientific theory, it is believed that the macromer includes at
least one carbon-carbon double bond, light absorption by the dye
can cause the dye to assume a triplet state, the triplet state
subsequently reacting with the amine to form a free radical which
initiates polymerization. Preferred dyes for use with these
materials include eosin dye and initiators such as
2,2-dimethyl-2-phenylacetophenone, 2-methoxy-2-phenylacetophenone,
and camphorquinone. Using such initiators, copolymers may be
polymerized in situ by LWUV light or by laser light of about 514
nm, for example.
[0088] Initiation of polymerization (crosslinking) is accomplished
by irradiation with light at a wavelength of between about 200-700
nm, most preferably in the long wavelength ultraviolet range or
visible range, 320 nm or higher, most preferably about 514 nm or
365 nm.
[0089] There are several photooxidizable and photoreductible dyes
that may be used to initiate polymerization (crosslinking). These
include acridine dyes, for example, acriblarine; thiazine dyes, for
example, thionine; xanthine dyes, for example, rose bengal; and
phenazine dyes, for example, methylene blue. These are used with
cocatalysis such as amines, for example, triethanolamine; sulphur
compounds, for example, RSO.sub.2R.sup.1; heterocycles, for
example, imidazole; enolates; organometallics; and other compounds,
such as N-phenyl glycine. Other initiators include camphorquinones
and acetophenone derivatives.
[0090] Thermal polymerization initiator systems may also be used.
Thermal initiators may be selected to allow polymerization to be
initiated at a desired temperature. At times it may be desired to
use a high temperature to initiate polymerization such as during a
molding process. For many medical uses it will be desired to use
systems that will initiate free radical polymerization at
physiological temperatures include, for example, potassium
persulfate, with or without tetramethyl ethylenediamine;
benzoylperoxide, with or without triethanolamine; and ammonium
persulfate with sodium bisulfite.
[0091] The crosslinked polymers (including copolymers) and blends
(hereinafter polymers) can be processed and used for many of the
same uses as described heretofor. In addition, crosslinked polymers
are particularly well suited for the prevention of surgical
adhesions, tissue adhesions, tissue coatings and in tissue
engineering.
[0092] A preferred application is a method of reducing formation of
adhesions after a surgical procedure in a patient. The method
includes coating damaged tissue surfaces in a patient with an
aqueous solution of a light-sensitive free-radical polymerization
initiator and a macromer solution as described above. The coated
tissue surfaces are exposed to light sufficient to polymerize the
macromer. The light-sensitive free-radical polymerization initiator
may be a single compound (e.g., 2,2-dimethoxy-2-phenyl
acetophenone) or a combination of a dye and a cocatalyst (e.g.,
ethyl eosin and triethanol amine).
[0093] Additionally, the crosslinked polymers can also be used to
form hydrogels which are a three dimensional network of hydrophilic
polymers in which a large amount of water is present. In general
the amount of water present in a hydrogel is at least 20 weight
percent of the total weight of the dry polymer. The most
characteristic property of these hydrogels is that it swells in the
presence of water and shrinks in the absence of water.
[0094] The extent of swelling (equilibrium water content) is
determined by the nature (mainly the hydrophilicity) of the polymer
chains and the crosslinking density.
[0095] The kinetics of hydrogel swelling is limited by the
diffusion of water through the outer layers of the dried hydrogel.
Therefore, while hydrogels swell to a large extent in water, the
time it takes to reach equilibrium swelling may be significant
depending on the size and shape of the hydrogel. To reduce the
amount of time it takes for a hydrogel to reach equilibrium,
hydrogel foams may be used. Hydrogels foams may be made by
crosslinking polymers in the presence of gas bubbles. The hydrogels
foams prepared with macroscopic gas cells will have an open celled
structure similar to sponges except that the pore size will
generally be an order of magnitude larger.
[0096] Hydrogels may be used for many of same uses that have been
described for polyoxaamides such as wound dressings materials,
since the crosslinked hydrogels are durable, non-antigenic, and
permeable to water vapor and metabolites, while securely covering
the wound to prevent bacterial infection. Hydrogels may also be
used for coatings in general and medical coatings in particular.
The hydrogel coatings may provide a smooth slippery surface and
prevent bacterial colonization on the surface of the medical
instrument. For example hydrogels may be used as coatings on
urinary catheter surfaces to improve its biocompatability.
Hydrogels may also be used in a variety of applications where the
mechanical swelling of the hydrogel is useful such as in catheters
as a blend component with a biocompatable elastomer (such as the
elastomer described in U.S. Pat. No. 5,468,253 hereby incorporated
by reference). Additionally, hydrogels could be used for drug
delivery or immobilization of enzyme substrates or cell
encapsulization. Other uses for hydrogels have been described in
the literature many of which are discussed in chapter one of
Hydrogels and Biodegradable Polymers for Bioapplications, published
by the Amercian Chemical Society (which is hereby incorporated by
reference herein).
[0097] Crosslinking to form crosslinked structures can be performed
in a variety of ways. For example the polymers may be crosslinked
while being synthesized such as by utilizing a multifuncitonal
monomers or oligomers. However, crosslinking at other times is also
advantageous. For example crosslinking may be performed during the
manufacture of a device such by adding a thermal initiator to the
polymer prior to injection molding a device. Additionally,
crosslinking of a polymerizable region with a photoinitiator may be
performed during stereolithography to form devices. European Patent
Application 93305586.5 describes the process for performing
stereolithography (with photopolymerizable materials). As
previously discussed photoinitiation may be used in viva to
crosslink the polymers of the present invention for various wound
treatments such as adhesion prevention and wound sealing. Coating
may also be applied to devices and crosslinked in situ to form
films that will conform to the surface of the device.
[0098] In a further embodiment of the present invention the
polyoxaamide polymers, polymer blends, pre-crosslinked and
post-crosslinked polymers of the present invention can be used in
tissue engineering applications as supports for cells. Appropriate
tissue scaffolding structures are known in the art such as the
prosthetic articular cartilage described in U.S. Pat. No.
5,306,311, the porous biodegradable scaffolding described in WO
94/25079, and the prevascularized implants described in WO 93/08850
(all hereby incorporated by reference herein). Methods of seeding
and/or culturing cells in tissue scaffoldings are also known in the
art such as those methods disclosed in EPO 422 209 B1, WO 88/03785,
WO 90/12604 and WO 95/33821 (all hereby incorporated by reference
herein). Additionally, the crosslinkable prepolymers of the present
invention can be used to encapsulate cells for tissue engineering
purposes.
[0099] The Examples set forth below are for illustration purposes
only, and are not intended to limit the scope of the claimed
invention in any way. Numerous additional embodiments within the
scope and spirit of the invention will become readily apparent to
those skilled in the art.
EXAMPLE 1
Preparation of 3,6-Dioxaoctanedioic Acid and its dimethylester
[0100] The diacid, 3,6-dioxaoctanedioic acid, was synthesized by
1
[0101] oxidation of triethylene glycol. The oxidation was carried
out in a 500 milliliter, three-neck round bottom flask equipped
with a thermometer, an additional funnel, a gas absorption tube and
a magnetic spinbar. The reaction flask was lowered into an oil bath
resting upon a magnetic stirrer. To the reaction flask was added
157.3 ml of a 60% nitric acid solution; 37.0 g of triethylene
glycol was added to the additional funnel. The contents of the
flask were heated to 78-80.degree. C. A test tube containing 0.5 g
of glycol and one milliliter of concentrated nitric acid was warmed
in a water bath until brown fumes started appearing. The contents
were then added to the reaction flask. The mixture was stirred for
a few minutes; the glycol was then carefully added. The rate of
addition had to be monitored extremely carefully to keep the
reaction under control. The addition rate was slow enough so that
the temperature of the exothermic reaction mixture was maintained
at 78-82.degree. C. After the addition was completed (80 minutes),
the temperature of the reaction mixture was maintained at
78-80.degree. C. for an additional hour. While continuing to
maintain this temperature range, the excess nitric acid and water
was then distilled off under reduced pressure (water suction). The
syrupy residue was cooled; some solids appeared. The reaction
product had the IR and NMR spectra expected for the dicarboxylic
acid; the crude product was used as such for esterification.
[0102] The crude diacid could be purified to the extent needed for
polymerization or alternately could be converted to the
corresponding diester, the diester purified and subsequently
hydrolyzed back to (purified) diacid. In yet another mode of
purification, the diamine salts of the diacids are purified and
then subsequently polymerized to form the polyoxaamides of the
present invention.
[0103] Esterification of the crude 3,6-dioxaoctanedioic acid was
accomplished as follows: To the reaction flask containing 36 g of
the crude diacid, was added 110 ml of methanol. This was stirred
for 3 days at room temperature after which 15 g of sodium
bicarbonate was added and stirred overnight. The mixture was
filtered to remove solids. To the liquor was added an additional 10
g of sodium bicarbonate; this mixture was stirred overnight. The
mixture was again filtered; the liquor was fractionally distilled.
NMR analysis of the esterified product showed a mixture of dimethyl
triglycolate (78.4 mole %) and monomethyltriglycolate (21.6 mole
%). No significant condensation of diacid was observed.
EXAMPLE 2
Preparation of polyoxaesteramide from 3,6-dioxaoctanedioic Acid and
ethanolamine
[0104] 2
[0105] A flame dried, mechanically stirred, 50-milliliter glass
reactor suitable for polycondensation reaction, is charged with the
equivalent of 0.1 mole of purified 3,6-dioxaoctanedioic acid from
Example 1 (17.81g), and 0.1 mole of ethanolamine (6.11 g). This
generally could be done by charging the reactor with exact
stoichometric amounts of the diacid and the amino alcohol;
alternately a small excess of ethylene glycol can be substituted
for a portion of the amino alcohol. The polymerization can be
conducted without additional catalyst or alternately a small amount
of catalyst (eg. 0.0606 ml of a solution of 0.33M stannous octoate
in toluene) can be added. After purging the reactor and venting
with nitrogen, the temperature is gradually raised over the course
of 26 hours to 180.degree.C. A temperature of 180.degree. C. is
then maintained for another 20 hours; all during these heating
periods under nitrogen at one atmosphere, the water formed is
collected. The reaction flask is allowed to cool to room
temperature; it is then slowly heated under reduced pressure
(0.015-1.0 mm) over the course of about 32 hours to 160.degree. C.,
during which time additional distillates can be collected. A
temperature of 160.degree. C. is maintained for 4 hours after which
a sample, a few grams in size, of the polymer formed is taken. The
sample is found to have an inherent viscosity (I.V.) of
approximately 0.2 dl/g, as determined in hexaflouroisopropanol
(HFIP) at 25.degree. C. at a concentration of 0.1 g/dl. The
polymerization is continued under reduced pressure while raising
the temperature, in the course of about 16 hours, from 160.degree.
C. to 180.degree. C.; a temperature of 180.degree. C. is maintained
for an additional 8 hours, at which time a polymer sample is taken
and found to have an I.V. of approximately 0.3 dl/g. The reaction
is continued under reduced pressure for another 8 hours at
180.degree. C. The resulting polymer should have an inherent
viscosity of approximately 0.4 dl/g, as determined in HFIP at 250C
and at a concentration of 0.1 g/dl.
EXAMPLE 3
Preparation of polyoxaamide with 3,6,9-trioxaundecanedioic Acid and
ethylene diamine
[0106] 3
[0107] A flame dried, mechanically stirred, 250-milliliter glass
reactor, suitable for polycondensation reaction, is charged with
the equivalent of 0.2 mole (44.44 g) of 3,6,9-trioxaundecanedioic
acid, and 0.2 mole (12.02 g) of ethylene diamine; this can be
conveniently done by charging the reactor with the stoichometric
salt formed between the diacid and the diamine. Alternately a small
excess of ethylene glycol can be substituted for a portion of the
diamine. The polymerization can be conducted without additional
catalyst or alternately a small amount of catalyst (eg. 0.0606 ml
of a solution of 0.33M stannous octoate in toluene or 10 milligrams
of dibutyltin oxide) can be added.
[0108] After purging the reactor and venting with nitrogen, the
contents of the reaction flask are gradually heated under nitrogen
at one atmosphere, in the course of about 32 hours, to 180.degree.
C., during which time the water formed is collected. The reaction
mass is allowed to cool to room temperature. The reaction mass is
then heated under reduced pressure (0.015-1.0 mm), gradually
increasing the temperature to 180.degree. C. in about 40 hours;
during this time additional distillates is collected. The
polymerization is continued under reduced pressure while
maintaining 180.degree. C. for an additional 16 hours. The
resulting polymer should have an inherent viscosity of
approximately 0.5 dl/g as determined in HFIP at 25.degree. C. and
at a concentration of 0.1 g/dl.
EXAMPLE 4
Preparation of polyoxaamide with polyglycol diacid and
Jeffamine
[0109] 4
[0110] A flame dried, mechanically stirred, 500-milliliter glass
reactor (suitable for polycondensation reaction) is charged with
the equivalent of 0.2 mole (123.8 g) of polyglycol diacid
(molecular weight about 619), and 0.2 mole (117.7g) of Jeffamine
(amine terminated polyethylene oxide). This generally could be done
by charging the reactor with stoichometric amounts of the diacid
and the diamine or by charging the corresponding preformed salt of
the diacid and diamine. As an alternate process, a small excess of
ethylene glycol can be substituted for a portion of the diamine.
The polymerization can be conducted without additional catalyst or
alternately a small amount of catalyst. After purging the reactor
and venting with nitrogen, the contents of the reaction flask is
heated under nitrogen at one atmosphere, gradually increasing the
temperature to 200.degree. C. in about 32 hours; during this time
the water formed is collected. The reaction flask is heated
gradually under reduced pressure (0.015-1.0 mm) from room
temperature to 140.degree. C. in about 24 hours, during which time
additional distillates are collected. A polymer sample of about ten
grams is taken at this stage, and found to have an I.V. of
approximately 0.1 dl/g in HFIP at 25.degree. C., 0.1 g/dl. The
polymerization is continued under reduced pressure while heating
from 140.degree. C. to 180.degree. C. in about 8 hours, and then
maintained at 180.degree. C. for an additional 8 hours. The
reaction temperature is then increased to 190.degree. C. and
maintained there under reduced pressure for an additional 8 hours.
The resulting polymer should have an inherent viscosity of
approximately 0.6 dl/g as determined in HFIP at 25.degree. C. and
at a concentration of 0.1 g/dl.
* * * * *