Patent | Date |
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Targeted disruption of the T cell receptor Grant 11,352,631 - Lee , et al. June 7, 2 | 2022-06-07 |
Methods and compositions for treating Huntington's Disease Grant 11,110,154 - Froelich , et al. September 7, 2 | 2021-09-07 |
Isolated human cell with an inactivated glucocorticoid receptor gene Grant 10,907,175 - Reik , et al. February 2, 2 | 2021-02-02 |
Methods and compositions for enhancing targeted transgene integration Grant 10,889,834 - Cost , et al. January 12, 2 | 2021-01-12 |
Methods and compositions for delivery of biologics Grant 10,883,119 - Cost January 5, 2 | 2021-01-05 |
Compositions for linking DNA-binding domains and cleavage domains Grant 10,724,020 - Miller , et al. | 2020-07-28 |
Methods and compositions for increased transgene expression Grant 10,717,993 - Holmes , et al. | 2020-07-21 |
Zinc finger nuclease-mediated homologous recombination Grant 10,669,551 - Cai , et al. | 2020-06-02 |
Optimized non-canonical zinc finger proteins Grant 10,662,434 - Cai , et al. | 2020-05-26 |
Method of treating mucopolysaccharidosis type I or II Grant 10,648,001 - Rebar | 2020-05-12 |
Methods and compositions for engineering immunity Grant 10,639,383 - Holmes , et al. | 2020-05-05 |
Delivery methods and compositions for nuclease-mediated genome engineering Grant 10,604,771 - Cannon , et al. | 2020-03-31 |
Methods and compositions for integration of an exogenous sequence within the genome of plants Grant 10,501,748 - Ainley , et al. Dec | 2019-12-10 |
HTT repressors and uses thereof Grant 10,435,441 - Froelich , et al. O | 2019-10-08 |
Method of treating factor IX deficiency using nuclease-mediated targeted integration Grant 10,370,680 - Holmes , et al. | 2019-08-06 |
Targeted modification of malate dehydrogenase Grant 10,358,684 - Shukla , et al. | 2019-07-23 |
Engineered zinc finger proteins targeting 5-enolpyruvyl shikimate-3-phosphate synthase genes Grant 10,344,289 - Gupta , et al. July 9, 2 | 2019-07-09 |
Genome Editing In Rats Using Zinc-finger Nucleases App 20190062789 - Cui; Xiaoxia ;   et al. | 2019-02-28 |
Methods and compositions for increasing transgene activity Grant 10,179,918 - Cost Ja | 2019-01-15 |
Methods and compositions for nuclease-mediated targeted integration of transgenes Grant 10,174,331 - Cost , et al. J | 2019-01-08 |
Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases Grant 10,155,011 - Bonini , et al. Dec | 2018-12-18 |
Delivery methods and compositions for nuclease-mediated genome engineering in hematopoietic stem cells Grant 10,117,899 - Genovese , et al. November 6, 2 | 2018-11-06 |
Methods and compositions for genome engineering Grant 10,081,661 - Miller , et al. September 25, 2 | 2018-09-25 |
Methods and compositions for treatment of a beta thalessemia Grant 10,072,066 - Liu , et al. September 11, 2 | 2018-09-11 |
Methods and compositions for modification of a HLA locus Grant 10,072,062 - Collingwood , et al. September 11, 2 | 2018-09-11 |
Methods and compositions for modulating PD1 Grant 10,046,028 - Gregory , et al. August 14, 2 | 2018-08-14 |
Compositions for linking DNA-binding domains and cleavage domains Grant 9,982,245 - Miller May 29, 2 | 2018-05-29 |
Methods and compositions for nuclease design Grant 9,970,001 - Miller May 15, 2 | 2018-05-15 |
Targeted genomic modification with partially single-stranded donor molecules Grant 9,970,028 - Cost , et al. May 15, 2 | 2018-05-15 |
Methods and compositions for treatment of a genetic condition Grant 9,963,715 - Cost , et al. May 8, 2 | 2018-05-08 |
FAD2 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks Grant 9,963,711 - Cogan , et al. May 8, 2 | 2018-05-08 |
Delivery methods and compositions for nuclease-mediated genome engineering Grant 9,957,526 - Holmes , et al. May 1, 2 | 2018-05-01 |
Nuclease-mediated regulation of gene expression Grant 9,957,501 - Reik , et al. May 1, 2 | 2018-05-01 |
Method of treating lysosomal storage diseases Grant 9,956,247 - Rebar May 1, 2 | 2018-05-01 |
Methods and compositions for treating trinucleotide repeat disorders Grant 9,943,565 - Gregory , et al. April 17, 2 | 2018-04-17 |
Targeted disruption of T cell receptor genes using talens Grant 9,937,207 - Gregory , et al. April 10, 2 | 2018-04-10 |
Targeted integration into the PPP1R12C locus Grant 9,914,940 - DeKelver , et al. March 13, 2 | 2018-03-13 |
FAD3 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks Grant 9,914,930 - Cogan , et al. March 13, 2 | 2018-03-13 |
Methods and compositions for treatment of a genetic condition Grant 9,902,974 - Conway , et al. February 27, 2 | 2018-02-27 |
Methods and compositions for inactivating alpha 1,6 fucosyltransferase (FUT8) gene expression Grant 9,890,395 - Collingwood , et al. February 13, 2 | 2018-02-13 |
Method of treating lysosomal storage diseases using nucleases and a transgene Grant 9,877,988 - Rebar January 30, 2 | 2018-01-30 |
Methods and compositions for treatment of a genetic condition Grant 9,873,894 - Conway , et al. January 23, 2 | 2018-01-23 |
Methods and compositions for modulating nuclease-mediated genome engineering in hematopoietic stem cells Grant 9,816,074 - Conway , et al. November 14, 2 | 2017-11-14 |
DNA-binding proteins and uses thereof Grant 9,783,827 - Gregory , et al. October 10, 2 | 2017-10-10 |
Methods and compositions for targeted cleavage and recombination Grant 9,782,437 - Holmes , et al. October 10, 2 | 2017-10-10 |
Methods and compositions for regulation of transgene expression Grant 9,777,281 - Rebar October 3, 2 | 2017-10-03 |
Methods and compositions for treating hemophilia Grant 9,771,403 - Miller , et al. September 26, 2 | 2017-09-26 |
Engineered cleavage half-domains for generating nuclease-mediated genomic modifications in a cell Grant 9,765,361 - Doyon , et al. September 19, 2 | 2017-09-19 |
Linear donor constructs for targeted integration Grant 9,765,360 - DeKelver , et al. September 19, 2 | 2017-09-19 |
Gene editing for HIV gene therapy Grant 9,757,420 - Gregory , et al. September 12, 2 | 2017-09-12 |
Methods and compostions for targeted genomic deletion Grant 9,752,140 - Urnov , et al. September 5, 2 | 2017-09-05 |
Compositions For Linking Dna-binding Domains And Cleavage Domains App 20170218349 - Miller; Jeffrey C. ;   et al. | 2017-08-03 |
Modification of CXCR4 using engineered zinc finger proteins Grant 9,717,759 - Holmes , et al. August 1, 2 | 2017-08-01 |
Targeted Disruption Of The T Cell Receptor App 20170211075 - Lee; Gary K. ;   et al. | 2017-07-27 |
Methods And Compositions For Engineering Immunity App 20170196992 - Holmes; Michael C. ;   et al. | 2017-07-13 |
Targeted deletion of cellular DNA sequences Grant 9,695,442 - Guschin , et al. July 4, 2 | 2017-07-04 |
Targeted Disruption Of The Mhc Cell Receptor App 20170173080 - Lee; Gary K. ;   et al. | 2017-06-22 |
Methods And Compositions For Increasing Rna Activity In A Cell App 20170137845 - Tan; Siyuan ;   et al. | 2017-05-18 |
Methods and compositions for treatment of a genetic condition Grant 9,650,648 - Cost , et al. May 16, 2 | 2017-05-16 |
Liver-specific Constructs, Factor Viii Expression Cassettes And Methods Of Use Thereof App 20170119906 - Riley; Brigit E. | 2017-05-04 |
Engineered zinc finger proteins targeting plant genes involved in fatty acid biosynthesis Grant 9,631,201 - DeKelver , et al. April 25, 2 | 2017-04-25 |
Methods and compositions for treating hemophilia B Grant 9,629,930 - Gregory , et al. April 25, 2 | 2017-04-25 |
Methods and compositions for gene correction Grant 9,631,187 - Jaenisch , et al. April 25, 2 | 2017-04-25 |
Methods and compositions for targeted single-stranded cleavage and targeted integration Grant 9,631,186 - Wang April 25, 2 | 2017-04-25 |
Modulation of stem cells using zinc finger proteins Grant 9,624,509 - Wolffe , et al. April 18, 2 | 2017-04-18 |
Methods and compositions for regulation of zinc finger protein expression Grant 9,624,498 - Froelich , et al. April 18, 2 | 2017-04-18 |
Gene correction of SCID-related genes in hematopoietic stem and progenitor cells Grant 9,616,090 - Conway , et al. April 11, 2 | 2017-04-11 |
Htt Repressors And Uses Thereof App 20170096460 - Froelich; Steven ;   et al. | 2017-04-06 |
Targeted Modification Of Malate Dehydrogenase App 20170088825 - Shukla; Vipula ;   et al. | 2017-03-30 |
T cell modifying compounds and uses thereof Grant 9,597,357 - Gregory , et al. March 21, 2 | 2017-03-21 |
Methods and compositions for prevention or treatment of a disease Grant 9,574,211 - Gregory , et al. February 21, 2 | 2017-02-21 |
Fad2 Performance Loci And Corresponding Target Site Specific Binding Proteins Capable Of Inducing Targeted Breaks App 20170044559 - Ainley; W. Michael ;   et al. | 2017-02-16 |
Genome editing of a Rosa locus using nucleases Grant 9,567,573 - Gregory , et al. February 14, 2 | 2017-02-14 |
Methods and compositions for inhibiting viral entry into cells Grant 9,566,352 - Holmes , et al. February 14, 2 | 2017-02-14 |
Compositions for linking DNA-binding domains and cleavage domains Grant 9,567,609 - Paschon , et al. February 14, 2 | 2017-02-14 |
Methods And Compositions For Treating Huntington's Disease App 20170035839 - Miller; Jeffrey C. ;   et al. | 2017-02-09 |
Delivery Methods And Compositions For Nuclease-mediated Genome Engineering App 20170016027 - Lee; Gary K. ;   et al. | 2017-01-19 |
Novel Dna-binding Proteins And Uses Thereof App 20170016030 - Gregory; Philip D. ;   et al. | 2017-01-19 |
Nuclease-mediated Regulation Of Gene Expression App 20160369262 - Reik; Andreas ;   et al. | 2016-12-22 |
Targeted modification of malate dehydrogenase Grant 9,523,098 - Shukla , et al. December 20, 2 | 2016-12-20 |
Engineered transcription activator like effector (TALE) proteins Grant 9,522,936 - Miller , et al. December 20, 2 | 2016-12-20 |
Rapid in vivo identification of biologically active nucleases Grant 9,506,120 - Doyon , et al. November 29, 2 | 2016-11-29 |
Methods and compositions for treating Huntington's disease Grant 9,499,597 - Miller , et al. November 22, 2 | 2016-11-22 |
Regulation of endogenous gene expression in cells using zinc finger proteins Grant 9,491,934 - Cox, III , et al. November 15, 2 | 2016-11-15 |
FAD2 performance loci and corresponding target site specific binding proteins capable of inducing targeted breaks Grant 9,493,779 - Ainley , et al. November 15, 2 | 2016-11-15 |
DNA-binding proteins and uses thereof Grant 9,493,750 - Gregory , et al. November 15, 2 | 2016-11-15 |
Methods And Compositions For Increasing Transgene Activity App 20160326548 - Cost; Gregory J. | 2016-11-10 |
Zinc Finger Nuclease-mediated Homologous Recombination App 20160326537 - Cai; Qihua C. ;   et al. | 2016-11-10 |
Methods And Compositions For Gene Inactivation App 20160326505 - Ando; Dale ;   et al. | 2016-11-10 |
Compositions For Linking Dna-binding Domains And Cleavage Domains App 20160312197 - Miller; Jeffrey C. | 2016-10-27 |
Methods And Compositions For Treating Huntington's Disease App 20160296605 - Zhang; H. Steve | 2016-10-13 |
Targeted Integration Into The Ppp1r12c Locus App 20160289699 - DeKelver; Russell ;   et al. | 2016-10-06 |
Modified DNA-binding proteins and uses thereof Grant 9,458,205 - Gregory , et al. October 4, 2 | 2016-10-04 |
Engineered Cleavage Half-domains App 20160265000 - Doyon; Yannick ;   et al. | 2016-09-15 |
Methods and compositions for gene inactivation Grant 9,434,776 - Ando , et al. September 6, 2 | 2016-09-06 |
Zinc finger nuclease-mediated homologous recombination Grant 9,428,756 - Cai , et al. August 30, 2 | 2016-08-30 |
Linear Donor Constructs For Targeted Integration App 20160237457 - DeKelver; Russell ;   et al. | 2016-08-18 |
Methods And Compositions For Modulating Pd1 App 20160220634 - Gregory; Philip D. ;   et al. | 2016-08-04 |
Modified Zinc Finger Binding Proteins App 20160222364 - Rebar; Edward J. ;   et al. | 2016-08-04 |
Methods and compositions for modulating PD1 Grant 9,402,879 - Gregory , et al. August 2, 2 | 2016-08-02 |
Methods And Compositions For Increased Transgene Expression App 20160215298 - Holmes; Michael C. ;   et al. | 2016-07-28 |
Compositions for linking DNA-binding domains and cleavage domains Grant 9,394,531 - Miller July 19, 2 | 2016-07-19 |
Methods and compositions for regulation of transgene expression Grant 9,394,545 - Rebar July 19, 2 | 2016-07-19 |
Methods and compositions for inactivating glutamine synthetase gene expression Grant 9,388,426 - Liu , et al. July 12, 2 | 2016-07-12 |
Methods And Compositions For Inactivating Alpha 1,6 Fucosyltransferase (fut8) Gene Expression App 20160194665 - Collingwood; Trevor ;   et al. | 2016-07-07 |
Engineered cleavage half-domains Grant 9,376,689 - Doyon , et al. June 28, 2 | 2016-06-28 |
Linear donor constructs for targeted integration Grant 9,376,685 - DeKelver , et al. June 28, 2 | 2016-06-28 |
Methods And Compostions For Targeted Genomic Deletion App 20160177290 - Urnov; Fyodor ;   et al. | 2016-06-23 |
Methods And Compositions For Enhancing Targeted Transgene Integration App 20160168593 - Cost; Gregory J. ;   et al. | 2016-06-16 |
Targeted Genomic Modification With Partially Single-stranded Donor Molecules App 20160145644 - Cost; Gregory J. ;   et al. | 2016-05-26 |
Methods And Compositions For Regulation Of Metabolic Disorders App 20160143953 - Gregory; Philip D. ;   et al. | 2016-05-26 |
Optimized Non-canonical Zinc Finger Proteins App 20160130314 - Cai; Qihua C. ;   et al. | 2016-05-12 |
Methods and compositions for inactivating alpha 1,6 fucosyltransferase (FUT8) gene expression Grant 9,322,036 - Collingwood , et al. April 26, 2 | 2016-04-26 |
DNA-binding proteins and uses thereof Grant 9,322,005 - Gregory , et al. April 26, 2 | 2016-04-26 |
Methods And Compositions For Treatment Of A Genetic Condition App 20160090607 - Conway; Anthony ;   et al. | 2016-03-31 |
Methods And Compositions For Treating Trinucleotide Repeat Disorders App 20160082081 - Gregory; Philip D. ;   et al. | 2016-03-24 |
Methods and compositions for targeted cleavage and recombination Grant 9,289,451 - Urnov , et al. March 22, 2 | 2016-03-22 |
Method Of Inactivating A Glucocorticoid Receptor Gene In An Isolated Cell App 20160076056 - Reik; Andreas ;   et al. | 2016-03-17 |
Genome Editing In Rats Using Zinc-finger Nucleases App 20160068865 - Cui; Xiaoxia ;   et al. | 2016-03-10 |
Methods And Compositions For The Treatment Of Lysosomal Storage Diseases App 20160060656 - Rebar; Edward J. | 2016-03-03 |
Methods and compositions for gene correction Grant 9,267,123 - Jaenisch , et al. February 23, 2 | 2016-02-23 |
Targeted integration into the PPP1R12C locus Grant 9,267,154 - DeKelver , et al. February 23, 2 | 2016-02-23 |
Methods And Compositions For Gene Correction App 20160046683 - Jaenisch; Rudolf ;   et al. | 2016-02-18 |
Methods And Compositions For Targeted Single-stranded Cleavage And Targeted Integration App 20160046915 - Wang; Jianbin | 2016-02-18 |
Targeted integration and expression on exogenous nucleic acid sequences Grant 9,260,726 - Gregory , et al. February 16, 2 | 2016-02-16 |
Targeted genomic modification with partially single-stranded donor molecules Grant 9,255,259 - Cost , et al. February 9, 2 | 2016-02-09 |
Isolated mouse or human cell having an exogenous transgene in an endogenous albumin gene Grant 9,255,250 - Gregory , et al. February 9, 2 | 2016-02-09 |
Gene Correction Of Scid-related Genes In Hematopoietic Stem And Progenitor Cells App 20160030477 - Conway; Anthony ;   et al. | 2016-02-04 |
Methods and compositions for targeted genomic deletion Grant 9,249,428 - Urnov , et al. February 2, 2 | 2016-02-02 |
Methods And Compositions For Modulating Nuclease-mediated Genome Engineering In Hematopoietic Stem Cells App 20160024474 - Conway; Anthony ;   et al. | 2016-01-28 |
Gene Editing For Hiv Gene Therapy App 20160022737 - Gregory; Philip D. ;   et al. | 2016-01-28 |
Methods And Compositions For Treating Hemophilia B App 20160022838 - Gregory; Philip D. ;   et al. | 2016-01-28 |
Modified zinc finger binding proteins Grant 9,238,803 - Rebar , et al. January 19, 2 | 2016-01-19 |
Screening Assays For Therapeutics For Parkinson's Disease App 20160010154 - LAGANIERE; Josee ;   et al. | 2016-01-14 |
Modified zinc finger binding proteins Grant 9,234,187 - Rebar , et al. January 12, 2 | 2016-01-12 |
Engineered zinc finger proteins for treating trinucleotide repeat disorders Grant 9,234,016 - Gregory , et al. January 12, 2 | 2016-01-12 |
Modified zinc finger binding proteins Grant 9,234,188 - Rebar , et al. January 12, 2 | 2016-01-12 |
Methods and compositions for modification of the HPRT locus Grant 9,222,105 - Cost , et al. December 29, 2 | 2015-12-29 |
Method of inactivating a glucocorticoid receptor gene in an isolated cell Grant 9,217,026 - Reik , et al. December 22, 2 | 2015-12-22 |
Methods And Compositions For Nuclease Design App 20150353917 - Miller; Jeffrey C. | 2015-12-10 |
Method of deleting an IgM gene in an isolated rat cell Grant 9,206,404 - Cui , et al. December 8, 2 | 2015-12-08 |
Methods And Compositions For Regulation Of Transgene Expression App 20150344893 - Rebar; Edward J. | 2015-12-03 |
Methods and compositions for targeted single-stranded cleavage and targeted integration Grant 9,200,266 - Wang December 1, 2 | 2015-12-01 |
Methods And Compositions For Treating Huntington's Disease App 20150335708 - Froelich; Steven ;   et al. | 2015-11-26 |
Methods And Compositions For Prevention Or Treatment Of A Disease App 20150329875 - Gregory; Philip D. ;   et al. | 2015-11-19 |
Optimized non-canonical zinc finger proteins Grant 9,187,758 - Cai , et al. November 17, 2 | 2015-11-17 |
Methods and compositions for treating hemophilia B Grant 9,175,280 - Gregory , et al. November 3, 2 | 2015-11-03 |
Engineered Transcription Activator Like Effector (tale) Proteins App 20150307561 - Miller; Jeffrey C. ;   et al. | 2015-10-29 |
Methods and compositions for alteration of a cystic fibrosis transmembrane conductance regulator (CFTR) gene Grant 9,161,995 - Guschin , et al. October 20, 2 | 2015-10-20 |
Compositions for linking zinc finger modules Grant 9,163,245 - Paschon , et al. October 20, 2 | 2015-10-20 |
Engineered cleavage half-domains Grant 9,150,879 - Doyon , et al. October 6, 2 | 2015-10-06 |
Methods and compositions for regulation of transgene expression Grant 9,150,847 - Rebar October 6, 2 | 2015-10-06 |
Methods And Compositions For Regulating Hiv Infection App 20150267223 - Holmes; Michael C. ;   et al. | 2015-09-24 |
Methods And Compositions For Regulation Of Zinc Finger Protein Expression App 20150267205 - Froelich; Steven ;   et al. | 2015-09-24 |
Methods And Compositions For Modification Of A Hla Locus App 20150252094 - Collingwood; Trevor ;   et al. | 2015-09-10 |
Rapid screening of biologically active nucleases and isolation of nuclease-modified cells Grant 9,121,072 - Holmes , et al. September 1, 2 | 2015-09-01 |
Methods And Compositions For Nuclease-mediated Targeted Integration App 20150240263 - Holmes; Michael C. ;   et al. | 2015-08-27 |
Rapid screening of biologically active nucleases and isolation of nuclease-modified cells Grant 9,115,409 - Doyon , et al. August 25, 2 | 2015-08-25 |
Linear Donor Constructs For Targeted Integration App 20150225727 - DeKelver; Russell ;   et al. | 2015-08-13 |
Methods And Compositions For Treatment Of A Beta Thalessemia App 20150218253 - Liu; Pei-Qi ;   et al. | 2015-08-06 |
Delivery Methods And Compositions For Nuclease-mediated Genome Engineering In Hematopoietic Stem Cells App 20150174169 - Genovese; Pietro ;   et al. | 2015-06-25 |
Targeted Disruption Of T Cell Receptor Genes Using Engineered Zinc Finger Protein Nucleases App 20150164954 - Bonini; Maria Chiara ;   et al. | 2015-06-18 |
Methods And Compositions For Treating Hemophilia App 20150166618 - Miller; Jeffrey C. ;   et al. | 2015-06-18 |
Methods And Compositions For Genome Engineering App 20150159172 - Miller; Jeffrey C. ;   et al. | 2015-06-11 |
Engineered Cleavage Half-domains App 20150159176 - Doyon; Yannick ;   et al. | 2015-06-11 |
Linear donor constructs for targeted integration Grant 9,045,763 - DeKelver , et al. June 2, 2 | 2015-06-02 |
Nuclease-mediated Regulation Of Gene Expression App 20150132269 - Orkin; Stuart H. ;   et al. | 2015-05-14 |
Modification Of Cxcr4 Using Engineered Zinc Finger Proteins App 20150110757 - Holmes; Michael C. ;   et al. | 2015-04-23 |
Delivery Methods And Compositions For Nuclease-mediated Genome Engineering App 20150110762 - Holmes; Michael C. ;   et al. | 2015-04-23 |
Targeted genomic modification with partially single-stranded donor molecules Grant 9,005,973 - Cost , et al. April 14, 2 | 2015-04-14 |
Methods And Compositions For Inactivating Glutamine Synthetase Gene Expression App 20150087067 - Liu; Pei-Qi ;   et al. | 2015-03-26 |
Compositions For Linking Dna-binding Domains And Cleavage Domains App 20150064789 - Paschon; David ;   et al. | 2015-03-05 |
Fad3 Performance Loci And Corresponding Target Site Specific Binding Proteins Capable Of Inducing Targeted Breaks App 20150067921 - Cogan; Noel ;   et al. | 2015-03-05 |
Engineered Zinc Finger Proteins Targeting 5-enolpyruvyl Shikimate-3-phosphate Synthase Genes App 20150064790 - Gupta; Manju ;   et al. | 2015-03-05 |
Methods And Compositions For Treatment Of A Genetic Condition App 20150056705 - Conway; Anthony ;   et al. | 2015-02-26 |
Engineered cleavage half-domains Grant 8,962,281 - Doyon , et al. February 24, 2 | 2015-02-24 |
Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases Grant 8,956,828 - Bonini , et al. February 17, 2 | 2015-02-17 |
Methods And Compositions For Modification Of Hla App 20150037304 - Gregory; Philip D. ;   et al. | 2015-02-05 |
Methods and compositions for modification of a HLA locus Grant 8,945,868 - Collingwood , et al. February 3, 2 | 2015-02-03 |
Methods And Compositions For Targeted Genomic Deletion App 20150031090 - Urnov; Fyodor ;   et al. | 2015-01-29 |
Methods and compositions for targeted integration Grant 8,936,936 - Holmes , et al. January 20, 2 | 2015-01-20 |
Optimized non-canonical zinc finger proteins Grant 8,921,112 - Cai , et al. December 30, 2 | 2014-12-30 |
Methods And Compositions For Targeted Cleavage And Recombination App 20140369980 - Holmes; Michael C. ;   et al. | 2014-12-18 |
DNA-binding proteins and uses thereof Grant 8,912,138 - Gregory , et al. December 16, 2 | 2014-12-16 |
Targeted Integration Into The Ppp1r12c Locus App 20140349394 - DeKelver; Russell ;   et al. | 2014-11-27 |
Methods and compositions for modification of the HPRT locus Grant 8,895,264 - Cost , et al. November 25, 2 | 2014-11-25 |
Engineered zinc finger proteins targeting 5-enolpyruvyl shikimate-3-phosphate synthase genes Grant 8,889,390 - Gupta , et al. November 18, 2 | 2014-11-18 |
Delivery Methods And Compositions For Nuclease-mediated Genome Engineering App 20140335063 - Cannon; Paula M. ;   et al. | 2014-11-13 |
Methods And Compositions For Treating Huntington's Disease App 20140336133 - Miller; Jeffrey C. ;   et al. | 2014-11-13 |
Regulation Of Endogenous Gene Expression In Cells Using Zinc Finger Proteins App 20140325691 - Cox III; George Norbert ;   et al. | 2014-10-30 |
Modification of CXCR4 using engineered zinc finger proteins Grant 8,871,905 - Holmes , et al. October 28, 2 | 2014-10-28 |
Methods And Compositions For Integration Of An Exogenous Sequence Within The Genome Of Plants App 20140304853 - Ainley; W. Michael ;   et al. | 2014-10-09 |
Targeted Disruption Of T Cell Receptor Genes Using Engineered Zinc Finger Protein Nucleases App 20140301990 - Gregory; Philip D. ;   et al. | 2014-10-09 |
Compositions For Linking Zinc Finger Modules App 20140287500 - Paschon; David ;   et al. | 2014-09-25 |
Methods and compositions for treating Huntington's Disease Grant 8,841,260 - Miller , et al. September 23, 2 | 2014-09-23 |
Methods And Compositions For Inactivating Alpha 1,6 Fucosyltransferase (fut8) Gene Expression App 20140273097 - Collingwood; Trevor ;   et al. | 2014-09-18 |
Targeted integration into the PPP1R12C locus Grant 8,822,221 - DeKelver , et al. September 2, 2 | 2014-09-02 |
Methods And Compositions For Enhancing Nuclease-mediated Gene Disruption App 20140242702 - Chen; Fuqiang ;   et al. | 2014-08-28 |
Modulation Of Stem Cells Using Zinc Finger Proteins App 20140234970 - Wolffe; Alan P. ;   et al. | 2014-08-21 |
Methods And Compositions For Targeted Single-stranded Cleavage And Targeted Integration App 20140212928 - Wang; Jianbin | 2014-07-31 |
Methods And Compositions For Alteration Of A Cystic Fibrosis Transmembrane Conductance Regulator (cftr) Gene App 20140205579 - Davis; Brian R. ;   et al. | 2014-07-24 |
Methods And Compositions For Increased Transgene Expression App 20140205576 - Holmes; Michael C. ;   et al. | 2014-07-24 |
Compositions for linking zinc finger modules Grant 8,772,453 - Paschon , et al. July 8, 2 | 2014-07-08 |
Methods and compositions for increasing nuclease activity Grant 8,772,008 - Doyon July 8, 2 | 2014-07-08 |
Genome editing of a Rosa locus using zinc-finger nucleases Grant 8,771,985 - Cui , et al. July 8, 2 | 2014-07-08 |
Methods and compositions for inactivating alpha 1,6 fucosyltransferase (FUT8) gene expression Grant 8,772,025 - Collingwood , et al. July 8, 2 | 2014-07-08 |
Methods and compositions for increasing nuclease activity Grant 8,772,009 - Doyon July 8, 2 | 2014-07-08 |
Engineered cleavage half-domains Grant 8,771,986 - Miller July 8, 2 | 2014-07-08 |
Methods And Compositions For Regulation Of Metabolic Disorders App 20140155468 - Gregory; Philip D. ;   et al. | 2014-06-05 |
Engineered Zinc Finger Proteins Targeting Plant Genes Involved In Fatty Acid Biosynthesis App 20140157458 - DeKelver; Russell ;   et al. | 2014-06-05 |
Modulation of stem cells using zinc finger proteins Grant 8,735,153 - Wolffe , et al. May 27, 2 | 2014-05-27 |
Methods And Compositions For Muscular Dystrophies App 20140140969 - Beausejour; Christian ;   et al. | 2014-05-22 |
Novel Dna-binding Proteins And Uses Thereof App 20140134740 - Gregory; Philip D. ;   et al. | 2014-05-15 |
Novel Dna-binding Proteins And Uses Thereof App 20140134723 - Gregory; Philip D. ;   et al. | 2014-05-15 |
Novel Dna-binding Proteins And Uses Thereof App 20140134741 - Gregory; Philip D. ;   et al. | 2014-05-15 |
Methods And Compositions For Gene Inactivation App 20140127811 - Ando; Dale ;   et al. | 2014-05-08 |
T Cell Modifying Compounds And Uses Thereof App 20140120622 - Gregory; Philip D. ;   et al. | 2014-05-01 |
Engineered Cleavage Half-domains App 20140120612 - Doyon; Yannick ;   et al. | 2014-05-01 |
Methods and compositions for targeted single-stranded cleavage and targeted integration Grant 8,703,489 - Wang April 22, 2 | 2014-04-22 |
Methods And Compositions For Treatment Of A Genetic Condition App 20140093913 - Cost; Gregory J. ;   et al. | 2014-04-03 |
Fad2 Performance Loci And Corresponding Target Site Specific Binding Proteins Capable Of Inducing Targeted Breaks App 20140090112 - Cogan; Noel ;   et al. | 2014-03-27 |
Fad2 Performance Loci And Corresponding Target Site Specific Binding Proteins Capable Of Inducing Targeted Breaks App 20140090116 - Ainley; William Michael ;   et al. | 2014-03-27 |
Zinc finger proteins for DNA binding and gene regulation in plants Grant 8,680,021 - Jamieson , et al. March 25, 2 | 2014-03-25 |
Methods And Compositions For Treatment Of A Genetic Condition App 20140080216 - Cost; Gregory J. ;   et al. | 2014-03-20 |
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Methods And Compositions For The Treatment Of Lysosomal Storage Diseases App 20140017212 - Rebar; Edward J. | 2014-01-16 |
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Targeted Modification Of Malate Dehydrogenase App 20130326725 - Shukla; Vipula ;   et al. | 2013-12-05 |
Methods and compositions for generation of Bax-and Bak-deficient cell lines Grant 8,597,912 - Collingwood , et al. December 3, 2 | 2013-12-03 |
Engineered zinc finger proteins targeting plant genes involved in fatty acid biosynthesis Grant 8,592,645 - DeKelver , et al. November 26, 2 | 2013-11-26 |
DNA-binding proteins and uses thereof Grant 8,586,526 - Gregory , et al. November 19, 2 | 2013-11-19 |
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Methods And Compositions For Inactivating Glutamine Synthetase Gene Expression App 20130164785 - Liu; Pei-Qi ;   et al. | 2013-06-27 |
Nucleic acid encoding a zinc finger that recognizes the sodium channel Nav 1.8 (PN3) gene Grant 8,466,267 - Collingwood June 18, 2 | 2013-06-18 |
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Methods And Compositions For Modification Of The Hprt Locus App 20130122591 - Cost; Gregory J. ;   et al. | 2013-05-16 |
Position Dependent Recognition Of Gnn Nucleotide Triplets By Zinc Fingers App 20130123484 - Liu; Qiang ;   et al. | 2013-05-16 |
Targeted deletion of cellular DNA sequences Grant 8,409,861 - Guschin , et al. April 2, 2 | 2013-04-02 |
Position dependent recognition of GNN nucleotide triplets by zinc fingers Grant 8,383,766 - Liu , et al. February 26, 2 | 2013-02-26 |
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Methods and Compositions for Gene Inactivation App 20120308528 - Ando; Dale ;   et al. | 2012-12-06 |
Regulation of endogenous gene expression in cells using zinc finger proteins App 20120294838 - Cox III; George Norbert ;   et al. | 2012-11-22 |
Zinc finger proteins and method for inactivating a dhfr gene in a chinese hamster ovary cell Grant 8,313,925 - Gregory , et al. November 20, 2 | 2012-11-20 |
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Rapid Screening Of Biologically Active Nucleases And Isolation Of Nuclease-modified Cells App 20120237926 - Holmes; Michael C. ;   et al. | 2012-09-20 |
Repressing endogenous CCR5 gene expression in cells using engineered zinc finger proteins Grant 8,268,618 - Cox, III , et al. September 18, 2 | 2012-09-18 |
Methods And Compositions For Treating Occular Disorders App 20120204282 - ZHANG; H. Steve | 2012-08-09 |
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Methods And Compositions For Analysis Of Regulatory Sequences App 20120088677 - URNOV; Fyodor ;   et al. | 2012-04-12 |
Methods and compositions for inactivating glutamine synthetase gene expression Grant 8,153,399 - Liu , et al. April 10, 2 | 2012-04-10 |
Engineered Cleavage Half-domains App 20120040398 - MILLER; Jeffrey C. | 2012-02-16 |
Targeted integration into the PPP1R12C locus Grant 8,110,379 - DeKelver , et al. February 7, 2 | 2012-02-07 |
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Novel DNA-binding proteins and uses thereof App 20110301073 - Gregory; Philip D. ;   et al. | 2011-12-08 |
Targeted modification of chromatin structure Grant 8,071,370 - Wolffe , et al. December 6, 2 | 2011-12-06 |
Regulation of angiogenesis with zinc finger proteins Grant 8,071,564 - Rebar , et al. December 6, 2 | 2011-12-06 |
Targeted genomic modification with partially single-stranded donor molecules App 20110287545 - Cost; Gregory J. ;   et al. | 2011-11-24 |
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Linear donor constructs for targeted integration App 20110281361 - DeKelver; Russell ;   et al. | 2011-11-17 |
Methods and compositions for increasing nuclease activity App 20110269234 - Doyon; Yannick | 2011-11-03 |
Genome editing of a Rosa locus using nucleases App 20110265198 - Gregory; Philip D. ;   et al. | 2011-10-27 |
Engineered cleavage half-domains Grant 8,034,598 - Miller October 11, 2 | 2011-10-11 |
Organisms homozygous for targeted modification App 20110247089 - Doyon; Yannick | 2011-10-06 |
Rapid screening of biologically active nucleases and isolation of nuclease-modified cells App 20110244474 - Holmes; Michael C. ;   et al. | 2011-10-06 |
Anti-angiogenic methods and compositions Grant 8,012,946 - Zhang , et al. September 6, 2 | 2011-09-06 |
Targeted genomic modification with partially single-stranded donor molecules App 20110207221 - Cost; Gregory J. ;   et al. | 2011-08-25 |
Regulation of endogenous gene expression in cells using zinc finger proteins Grant 7,985,887 - Cox, III , et al. July 26, 2 | 2011-07-26 |
Methods and compositions for targeted cleavage and recombination Grant 7,972,854 - Miller , et al. July 5, 2 | 2011-07-05 |
Targeted disruption of T cell receptor genes using engineered zinc finger protein nucleases App 20110158957 - Bonini; Maria Chiara ;   et al. | 2011-06-30 |
Methods and compositions for inactivating alpha 1,6 fucosyltransferase (FUT8) gene expression App 20110159541 - Collingwood; Trevor ;   et al. | 2011-06-30 |
Methods and compositions for modulating PD1 App 20110136895 - Gregory; Philip D. ;   et al. | 2011-06-09 |
Methods and compositions for gene inactivation Grant 7,951,925 - Ando , et al. May 31, 2 | 2011-05-31 |
Compositions and methods for regulation of plant gamma-tocopherol methyltransferase Grant 7,947,873 - Li , et al. May 24, 2 | 2011-05-24 |
Randomized libraries of zinc finger proteins Grant 7,943,553 - Case , et al. May 17, 2 | 2011-05-17 |
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Libraries of regulatory sequences, methods of making and using same Grant 7,923,542 - Wolffe , et al. April 12, 2 | 2011-04-12 |
Methods and compositions for treating trinucleotide repeat disorders App 20110082093 - GREGORY; PHILIP D. ;   et al. | 2011-04-07 |
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Anti-angiogenic methods and compositions Grant 7,893,022 - Zhang , et al. February 22, 2 | 2011-02-22 |
Organisms homozygous for targeted modification App 20110041195 - Doyon; Yannick | 2011-02-17 |
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Methods and compositions for targeted cleavage and recombination App 20110030076 - Urnov; Fyodor ;   et al. | 2011-02-03 |
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Targeted modification of chromatin structure App 20100323424 - Wolffe; Alan P. ;   et al. | 2010-12-23 |
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Modification of CXCR4 using engineered zinc finger proteins App 20100291048 - Holmes; Michael C. ;   et al. | 2010-11-18 |
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Methods and compositions for treating neuropathic and neurodegenerative conditions App 20100256221 - Martin; J. Tyler | 2010-10-07 |
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Methods and compositions for gene inactivation App 20100111907 - Ando; Dale ;   et al. | 2010-05-06 |
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Methods and compositions for targeted single-stranded cleavage and targeted integration App 20100047805 - Wang; Jianbin | 2010-02-25 |
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Engineered cleavage half-domains App 20090311787 - Miller; Jeffrey C. | 2009-12-17 |
Engineered cleavage half-domains App 20090305346 - Miller; Jeffrey C. | 2009-12-10 |
Methods and compositions for using zinc finger endonucleases to enhance homologous recombination App 20090305402 - Liljedahl; Monika ;   et al. | 2009-12-10 |
Compositions for linking DNA-binding domains and cleavage domains App 20090305419 - Miller; Jeffrey C. | 2009-12-10 |
Linear donor constructs for targeted integration App 20090263900 - DeKelver; Russell ;   et al. | 2009-10-22 |
Targeted integration and expression of exogenous nucleic acid sequences App 20090258363 - Gregory; Philip D. ;   et al. | 2009-10-15 |
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Genomic editing in zebrafish using zinc finger nucleases App 20090203140 - AMACHER; SHARON ;   et al. | 2009-08-13 |
Modulation of gene expression using insulator binding proteins App 20090181455 - Wolffe; Alan P. ;   et al. | 2009-07-16 |
Methods and compositions for targeted integration App 20090117617 - Holmes; Michael C. ;   et al. | 2009-05-07 |
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Methods and compositions for inactivating alpha 1,6 fucosyltransferase (FUT8) gene expression App 20090042250 - Collingwood; Trevor ;   et al. | 2009-02-12 |
Targeted modification of chromatin structure App 20090023153 - Wolffe; Alan P. ;   et al. | 2009-01-22 |
Methods and compositions for increased transgene expression App 20080311095 - Holmes; Michael C. ;   et al. | 2008-12-18 |
Targeted integration into the PPP1R12C locus App 20080299580 - DeKelver; Russell ;   et al. | 2008-12-04 |
Simultaneous modulation of multiple genes App 20080233641 - Miller; Jeffrey ;   et al. | 2008-09-25 |
Methods and compositions for using zinc finger endonucleases to enhance homologous recombination App 20080209587 - Liljedahl; Monika ;   et al. | 2008-08-28 |
Anti-angiogenic methods and compositions App 20080187523 - Zhang; H. Steve ;   et al. | 2008-08-07 |
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Anti-angiogenic methods and compositions App 20080118469 - Zhang; H. Steve ;   et al. | 2008-05-22 |
Anti-angiogenic methods and compositions App 20080108556 - Zhang; H. Steve ;   et al. | 2008-05-08 |
Regulated gene expression in plants App 20080070306 - Choo; Yen ;   et al. | 2008-03-20 |
Methods and compositions for inactivation of dihydrofolate reductase App 20080015164 - Collingwood; Trevor | 2008-01-17 |
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Methods and compositions for targeted cleavage and recombination App 20070218528 - Miller; Jeffrey C. | 2007-09-20 |
Targeted integration and expression of exogenous nucleic acid sequences App 20070134796 - Holmes; Michael C. ;   et al. | 2007-06-14 |
Regulation of angiogenesis with zinc finger proteins App 20070072818 - Rebar; Edward ;   et al. | 2007-03-29 |