Patent | Date |
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Treating cognitive decline and other neurodegenerative conditions by selectively removing senescent cells from neurological tissue Grant 11,351,167 - Laberge , et al. June 7, 2 | 2022-06-07 |
Treatment Of Parkinson's Disease And Other Conditions Caused Or Mediated By Senescent Astrocytes Using Small Molecule Senolytic Agents App 20220096466 - Chinta; Shankar J. ;   et al. | 2022-03-31 |
Treating Cardiovascular Disease By Selectively Eliminating Senescent Cells App 20210169875 - Laberge; Remi-Martin ;   et al. | 2021-06-10 |
Treating Liver Disease By Selectively Eliminating Senescent Cells App 20210169876 - Laberge; Remi-Martin ;   et al. | 2021-06-10 |
Treating Cognitive Decline And Other Neurodegenerative Conditions By Selectively Removing Senescent Cells From Neurological Tissue App 20210030752 - Laberge; Remi-Martin ;   et al. | 2021-02-04 |
Inhibitors of HSP90, PI3-Kinase, Proteasome, HDAC, and P97 Pathways for Selective Removal of Senescent Cells in the Treatment of Age Related Conditions App 20200360386 - Hudson; Ryan ;   et al. | 2020-11-19 |
Treatment of Lung Diseases Using Pharmaceutical Agents that Eliminate Senescent Cells App 20200354336 - Vlahakis; Nick ;   et al. | 2020-11-12 |
Use of a Heterocyclic Bcl-xL Inhibitor and Related Analogs for Removing Senescent Cells in the Treatment of Eye Diseases and Other Age-Related Conditions App 20200338094 - David; Nathaniel ;   et al. | 2020-10-29 |
Use Of A Heterocyclic Bcl-2 Inhibitor For Removing Senescent Cells And Treating Senescence-associated Conditions App 20200338097 - David; Nathaniel ;   et al. | 2020-10-29 |
Treatment of Lung Diseases Using Pharmaceutical Agents that Eliminate Senescent Cells App 20200199103 - Vlahakis; Nick ;   et al. | 2020-06-25 |
Peptide-based proteasome inhibitors for treating conditions mediated by senescent cells and for treating cancer Grant 10,689,416 - Hudson , et al. | 2020-06-23 |
Nucleic acid construct with a p16 promoter that causes a prodrug converting enzyme to be expressed specifically in senescent cells Grant 10,655,144 - Demaria , et al. | 2020-05-19 |
Treating Cognitive Decline And Other Neurodegenerative Conditions By Selectively Removing Senescent Cells From Neurological Tiss App 20200030323 - Laberge; Remi-Martin ;   et al. | 2020-01-30 |
Peptide-based proteasome inhibitors for treating conditions mediated by senescent cells and for treating cancer App 20200002378 - Hudson; Ryan ;   et al. | 2020-01-02 |
Peptide-based proteasome inhibitors for treating conditions mediated by senescent cells and for treating cancer Grant 10,519,197 - Hudson , et al. Dec | 2019-12-31 |
Removing senescent cells from a mixed cell population or tissue using a phosphoinositide 3-kinase (PI3K) inhibitor Grant 10,517,866 - Laberge , et al. Dec | 2019-12-31 |
Compositions of matter for treatment of ophthalmic conditions by selectively removing senescent cells from the eye Grant 10,478,432 - Laberge , et al. Nov | 2019-11-19 |
Unit dose of an aryl sulfonamide that is effective for treating eye disease and averting potential vision loss Grant 10,478,433 - Laberge , et al. Nov | 2019-11-19 |
Therapy For Removing Senescent Cells And Treating Senescence-associated Disease Using An Mdm2 Inhibitor App 20190343832 - Laberge; Remi-Martin ;   et al. | 2019-11-14 |
Methods and compositions for killing senescent cells and for treating senescence-associated diseases and disorders using an inhibitor of Akt kinase Grant 10,413,542 - Laberge , et al. Sept | 2019-09-17 |
Treatment Of Parkinson's Disease And Other Conditions Caused Or Mediated By Senescent Astrocytes Using Small Molecule Senolytic App 20190269675 - Chinta; Shankar J. ;   et al. | 2019-09-05 |
Use of sulfonamide inhibitors of BCL-2 and BCL-xL to treat ophthalmic disease by selectively removing senescent cells Grant 10,328,073 - Laberge , et al. | 2019-06-25 |
Treating atherosclerosis by removing senescent foam cell macrophages from atherosclerotic plaques Grant 10,328,058 - Baker , et al. | 2019-06-25 |
Chemical Compounds For Treating Atherosclerosis By Stabilizing Atherosclerotic Plaques Or Delaying Atherogenesis App 20190175623 - Laberge; Remi-Martin ;   et al. | 2019-06-13 |
Treating pulmonary conditions by selectively removing senescent cells from the lung using an intermittent dosing regimen Grant 10,258,618 - Laberge , et al. | 2019-04-16 |
Method of optimizing conditions for selectively removing a plurality of senescent cells from a tissue or a mixed cell population Grant 10,213,426 - Laberge , et al. Feb | 2019-02-26 |
Use Of Sulfonamide Inhibitors Of Bcl-2 And Bcl-xl To Treat Ophthalmic Disease By Selectively Removing Senescent Cells App 20190022090 - Laberge; Remi-Martin ;   et al. | 2019-01-24 |
Pharmaceutical Products and Drug Combinations for Treating Atherosclerosis by Stabilizing Atherosclerotic Plaques and Promoting Plaque Regression App 20190000846 - van Deursen; Jan M.A. ;   et al. | 2019-01-03 |
Treatment of joint pain Grant 10,130,628 - David , et al. November 20, 2 | 2018-11-20 |
Unit Dose of an MDM2 Inhibitor that Provides Long-Lasting Relief from Idiopathic Pulmonary Fibrosis and other Pulmonary Conditions by Selectively Removing Senescent Cells from the Lung App 20180303828 - Laberge; Remi-Martin ;   et al. | 2018-10-25 |
Methods and Compositions for Killing Senescent Cells and for Treating Senescence-Associated Diseases and Disorders App 20180256568 - Laberge; Remi-Martin ;   et al. | 2018-09-13 |
Removing Senescent Cells From A Mixed Cell Population Or Tissue Using A Phosphoinositide 3-kinase (pi3k) Inhibitor App 20180250296 - Laberge; Remi-Martin ;   et al. | 2018-09-06 |
Treating Pulmonary Conditions By Selectively Removing Senescent Cells From The Lung Using An Intermittent Dosing Regimen App 20180235956 - Laberge; Remi-Martin ;   et al. | 2018-08-23 |
Treatment of Ophthalmic Conditions by Selectively Removing Senescent Cells from the Eye App 20180235957 - Laberge; Remi-Martin ;   et al. | 2018-08-23 |
Compositions And Methods For Treating Senescence-associated Diseases And Disorders App 20180193458 - Lopez-Dominguez; Jose Alberto ;   et al. | 2018-07-12 |
Treatment of ophthalmic conditions by selectively removing senescent cells from the eye Grant 10,010,546 - Laberge , et al. July 3, 2 | 2018-07-03 |
Treatment for osteoarthritis in a joint by administering a means for inhibiting MDM2 Grant 9,993,472 - Laberge , et al. June 12, 2 | 2018-06-12 |
Use of sulfonamide inhibitors of Bcl-2 to treat senescence-associated lung conditions such as pulmonary fibrosis and chronic obstructive pulmonary disease Grant 9,980,962 - Laberge , et al. May 29, 2 | 2018-05-29 |
Nucleic Acid Construct with a p16 Promoter that Causes a Prodrug Converting Enzyme to be Expressed Specifically in Senescent Cells App 20180139939 - Demaria; Marco ;   et al. | 2018-05-24 |
Treatment Of Ophthalmic Conditions By Selectively Removing Senescent Cells From The Eye App 20180117038 - Laberge; Remi-Martin ;   et al. | 2018-05-03 |
Treatment for Idiopathic Pulmonary Fibrosis and Chronic Obstructive Pulmonary Disease App 20180110787 - Laberge; Remi-Martin ;   et al. | 2018-04-26 |
Transgenic mouse having a transgene that converts a prodrug into a cytotoxic compound in senescent cells Grant 9,901,080 - Campisi , et al. February 27, 2 | 2018-02-27 |
Transgenic mouse for determining the role of senescent cells in cancer Grant 9,901,081 - Campisi , et al. February 27, 2 | 2018-02-27 |
Inhibiting activity of senescent cells using a glucocorticoid Grant 9,884,065 - Campisi , et al. February 6, 2 | 2018-02-06 |
Use of a Heterocyclic Bcl-xL Inhibitor and Related Analogs for Removing Senescent Cells in the Treatment of Eye Diseases and Other Age-Related Conditions App 20180000816 - David; Nathaniel ;   et al. | 2018-01-04 |
Treatment for osteoarthritis by intra-articular administration of a cis-imidazoline Grant 9,855,266 - Laberge , et al. January 2, 2 | 2018-01-02 |
Unit dose of a cis-imidazoline for treating an osteoarthritic joint by removing senescent cells Grant 9,849,128 - Laberge , et al. December 26, 2 | 2017-12-26 |
Methods And Compositions For Killing Senescent Cells And For Treating Senescence-associated Diseases And Disorders App 20170348307 - Laberge; Remi-Martin ;   et al. | 2017-12-07 |
Treatment of Pain App 20170326136 - David; Nathaniel ;   et al. | 2017-11-16 |
Use Of A Heterocyclic Bcl-2 Inhibitor For Removing Senescent Cells And Treating Senescence-associated Conditions App 20170266211 - David; Nathaniel ;   et al. | 2017-09-21 |
Methods And Compositions For Killing Senescent Cells And For Treating Senescence-associated Diseases And Disorders App 20170224680 - Laberge; Remi-Martin ;   et al. | 2017-08-10 |
Methods And Compositions For Killing Senescent Cells And For Treating Senescence-associated Diseases And Disorders App 20170209435 - Laberge; Remi-Martin ;   et al. | 2017-07-27 |
Methods And Compositions For Killing Senescent Cells And For Treating Senescence-associated Diseases And Disorders App 20170196857 - Laberge; Remi-Martin ;   et al. | 2017-07-13 |
Methods And Compositions For Killing Senescent Cells And For Treating Senescence-associated Diseases And Disorders App 20170196858 - Laberge; Remi-Martin ;   et al. | 2017-07-13 |
Methods And Compositions For Killing Senescent Cells And For Treating Senescence-associated Diseases And Disorders App 20170198253 - Laberge; Remi-Martin ;   et al. | 2017-07-13 |
Animal Models Of Age-related Disorders And Age-sensitive Traits Associated With Senescence-inducing Stimuli And Uses Thereof App 20170027139 - van Deursen; Jan M.A. ;   et al. | 2017-02-02 |
Methods And Compositions For Killing Senescent Cells And For Treating Senescence-associated Diseases And Disorders App 20160339019 - Laberge; Remi-Martin ;   et al. | 2016-11-24 |
Targeting Senescent Cells And Cancer Cells By Interference With Jnk And/or Foxo4 App 20130288981 - de KEIZER; Peterus Leonardus-Josephus ;   et al. | 2013-10-31 |
Targeting Senescent And Cancer Cells For Selective Killing By Interference With Foxo4 App 20130288980 - De Keizer; Peterus Leonardus-Josephus ;   et al. | 2013-10-31 |