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Nucleoside Derivatives As Inhibitors Of Rna-dependent Rna Viral Polyermase App 20170183373 - Bhat; Balkrishen ;   et al. | 2017-06-29 |
Nucleoside Derivatives As Inhibitors Of Rna-dependent Rna Viral Polymerase App 20140309412 - Bhat; Balkrishen ;   et al. | 2014-10-16 |
Compositions and methods for non-parenteral delivery of oligonucleotides Grant 8,691,785 - Teng , et al. April 8, 2 | 2014-04-08 |
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Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase Grant 8,481,712 - Bhat , et al. July 9, 2 | 2013-07-09 |
Compositions and methods for non-parenteral delivery of oligonucleotides Grant 8,377,897 - Teng , et al. February 19, 2 | 2013-02-19 |
Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase App 20120165515 - Bhat; Balkrishen ;   et al. | 2012-06-28 |
Composition and methods for the pulmonary delivery of nucleic acids Grant 8,153,602 - Bennett , et al. April 10, 2 | 2012-04-10 |
Compositions And Methods For Topical Delivery Of Oligonucleotides App 20110213014 - Mehta; Rahul C. ;   et al. | 2011-09-01 |
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Novel Tricyclic Nucleosides Or Nucleotides As Therapeutic Agents App 20100311684 - Cook; Phillip Dan ;   et al. | 2010-12-09 |
Tricyclic nucleosides or nucleotides as therapeutic agents Grant 7,713,941 - Cook , et al. May 11, 2 | 2010-05-11 |
Compositions And Methods For Topical Delivery Of Oligonucleotides App 20090326045 - Mehta; Rahul C. ;   et al. | 2009-12-31 |
2'-Modified Oligonucleotides App 20090198047 - Cook; Phillip Dan ;   et al. | 2009-08-06 |
Novel Tricyclic Nucleosides or Nucleotides as Therapeutic Agents App 20080200423 - Cook; Phillip Dan ;   et al. | 2008-08-21 |
2'-modified Oligonucleotides App 20080032945 - Cook; Phillip Dan ;   et al. | 2008-02-07 |
Thionucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase Grant 7,323,449 - Olsen , et al. January 29, 2 | 2008-01-29 |
Nucleoside derivatives as inhibitors of rna-dependent RNA viral polymerase App 20070275912 - Bhat; Balkrishen ;   et al. | 2007-11-29 |
Compositions and methods for non-parenteral delivery of oligonucleotides App 20070249551 - Teng; Ching-Leou ;   et al. | 2007-10-25 |
Process For The Synthesis Of 2'-O-Substituted Pyrimidines And Oligomeric Compounds Therefrom App 20070232798 - Cook; Phillip Dan ;   et al. | 2007-10-04 |
Tricyclic nucleosides or nucleotides as therapeutic agents Grant 7,268,119 - Cook , et al. September 11, 2 | 2007-09-11 |
Derivatized oligonucleotides having improved uptake and other properties Grant 7,235,650 - Manoharan , et al. June 26, 2 | 2007-06-26 |
Novel Tricyclic Nucleosides Or Nucleotides As Therapeutic Agents App 20070135363 - Cook; Phillip Dan ;   et al. | 2007-06-14 |
Oligonucleotdies having A-DNA form and B-DNA form conformational geometry App 20070123702 - Manoharan; Muthiah ;   et al. | 2007-05-31 |
Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase Grant 7,202,224 - Eldrup , et al. April 10, 2 | 2007-04-10 |
Gapped 2' Modified Oligonucleotides App 20070032446 - Cook; Phillip Dan ;   et al. | 2007-02-08 |
Oligonucleolotides having site specific chiral phosphorothioate internucleoside linkages Grant RE39,464 - Cook , et al. January 9, 2 | 2007-01-09 |
Gapped 2' Modified Oligonucleotides App 20060270624 - Cook; Phillip Dan ;   et al. | 2006-11-30 |
Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase App 20060264390 - Eldrup; Anne B. ;   et al. | 2006-11-23 |
Sugar modified oligonucleotides Grant 7,138,517 - Cook , et al. November 21, 2 | 2006-11-21 |
Derivatized oligonucleotides having improved uptake and other properties Grant 7,125,975 - Manoharan , et al. October 24, 2 | 2006-10-24 |
Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase Grant 7,125,855 - Bhat , et al. October 24, 2 | 2006-10-24 |
Derivatized oligonucleotides having improved uptake and other properties Grant 7,122,649 - Manoharan , et al. October 17, 2 | 2006-10-17 |
Oligonucleotides having A-DNA form and B-DNA form conformational geometry Grant 7,119,184 - Manoharan , et al. October 10, 2 | 2006-10-10 |
Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase App 20060205686 - Bhat; Balkrishen ;   et al. | 2006-09-14 |
Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase Grant 7,105,499 - Carroll , et al. September 12, 2 | 2006-09-12 |
Oligonucleotides containing 2'-O-modified purines Grant 7,101,993 - Cook , et al. September 5, 2 | 2006-09-05 |
Amine-derivatized nucleosides and oligonucleosides Grant 7,037,646 - Cook , et al. May 2, 2 | 2006-05-02 |
Gapped oligonucleotides Grant 7,015,315 - Cook , et al. March 21, 2 | 2006-03-21 |
Nucleobase heterocyclic combinatorialization Grant 6,991,902 - Cook January 31, 2 | 2006-01-31 |
C3' -methylene hydrogen phosphonate oligomers and related compounds Grant 6,974,865 - Cook , et al. December 13, 2 | 2005-12-13 |
Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase App 20050272676 - Bhat, Balkrishen ;   et al. | 2005-12-08 |
Methods for processing chemical compounds having reactive functional groups Grant 6,942,966 - Cook September 13, 2 | 2005-09-13 |
Derivatized oligonucleotides having improved uptake and other properties App 20050158727 - Manoharan, Muthiah ;   et al. | 2005-07-21 |
Derivatized oligonucleotides having improved uptake and other properties Grant 6,919,439 - Manoharan , et al. July 19, 2 | 2005-07-19 |
Methods of using mammalian RNase H and compositions thereof App 20050153921 - Monia, Brett P. ;   et al. | 2005-07-14 |
Guanidinium functionalized intermediates Grant 6,914,148 - Manoharan , et al. July 5, 2 | 2005-07-05 |
Amine-derivatized nucleosides and oligonucleosides Grant 6,900,297 - Cook , et al. May 31, 2 | 2005-05-31 |
Backbone modified oligonucleotide analogues Grant 6,900,301 - Cook , et al. May 31, 2 | 2005-05-31 |
.alpha.-modified nucleoside triphosphates Grant 6,900,308 - Wyrzykiewicz , et al. May 31, 2 | 2005-05-31 |
Gapped 2' modified oligonucleotides App 20050112563 - Cook, Phillip Dan ;   et al. | 2005-05-26 |
Nucleobase heterocyclic combinatorialization Grant 6,893,815 - Cook May 17, 2 | 2005-05-17 |
Compositions and methods for topical delivery of oligonucleotides App 20050096287 - Mehta, Rahul C. ;   et al. | 2005-05-05 |
Carbamate-derivatized nucleosides and oligonucleosides App 20050074771 - Cook, Phillip Dan ;   et al. | 2005-04-07 |
Processes for the synthesis of 2'-O-substituted pyrimidines and oligomeric compounds therefrom App 20050059815 - Cook, Phillip Dan ;   et al. | 2005-03-17 |
Nucleosidic and non-nucleosidic folate conjugates Grant 6,861,514 - Cook , et al. March 1, 2 | 2005-03-01 |
Derivatized oligonucleotides having improved uptake and other properties App 20050043219 - Manoharan, Muthiah ;   et al. | 2005-02-24 |
Oligonucleotide analogs having modified dimers Grant 6,849,723 - Cook , et al. February 1, 2 | 2005-02-01 |
Compositions and methods for topical delivery of oligonucleotides Grant 6,841,539 - Mehta , et al. January 11, 2 | 2005-01-11 |
Derivatized oligonucleotides having improved uptake and other properties Grant 6,831,166 - Manoharan , et al. December 14, 2 | 2004-12-14 |
Compositions and methods for non-parenteral delivery of oligonucleotides App 20040229831 - Teng, Ching-Leou ;   et al. | 2004-11-18 |
Phosphorothioate oligonucleotides having modified internucleoside linkages Grant 6,811,975 - Cook , et al. November 2, 2 | 2004-11-02 |
Carbamate-derivatized nucleosides and oligonucleosides Grant 6,803,198 - Cook , et al. October 12, 2 | 2004-10-12 |
Complex chemical libraries Grant 6,800,444 - Cook , et al. October 5, 2 | 2004-10-05 |
Amine-derivatized nucleosides and oligonucleosides Grant 6,783,931 - Cook , et al. August 31, 2 | 2004-08-31 |
Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase of hepatitis C virus Grant 6,777,395 - Bhat , et al. August 17, 2 | 2004-08-17 |
Compositions and methods for enhanced biostability and altered biodistribution of oligonucleotides in mammals App 20040142899 - Cook, Phillip Dan ;   et al. | 2004-07-22 |
Peptide nucleic acid combinatorial libraries and improved methods of synthesis Grant 6,756,199 - Cook , et al. June 29, 2 | 2004-06-29 |
Compositions and methods for enhanced biostability and altered biodistribution of oligonucleotides in mammals Grant 6,753,423 - Cook , et al. June 22, 2 | 2004-06-22 |
Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase App 20040110717 - Carroll, Steven S. ;   et al. | 2004-06-10 |
Compositions and methods for non-parenteral delivery of oligonucleotides Grant 6,747,014 - Teng , et al. June 8, 2 | 2004-06-08 |
Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase App 20040072788 - Bhat, Balkrishen ;   et al. | 2004-04-15 |
Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase App 20040067901 - Bhat, Balkrishen ;   et al. | 2004-04-08 |
Nucleotide mimics and their prodrugs App 20040059104 - Cook, Phillip Dan ;   et al. | 2004-03-25 |
Oligonucleotides containing 2'-0-modified purines App 20040048826 - Cook, Phillip Dan ;   et al. | 2004-03-11 |
Oligonucleotides having chiral phosphorus linkages Grant 6,699,979 - Cook March 2, 2 | 2004-03-02 |
Gapped 2' modified oligonucleotides App 20040038274 - Cook, Phillip Dan ;   et al. | 2004-02-26 |
Oligonucleotides having modified nucleoside units App 20040014108 - Eldrup, Anne B. ;   et al. | 2004-01-22 |
Oligonucleotides having modified nucleoside units App 20040014957 - Eldrup, Anne ;   et al. | 2004-01-22 |
Methods of enhancing renal uptake of oligonucleotides App 20040009938 - Manoharan, Muthiah ;   et al. | 2004-01-15 |
2'-O-aminoethyloxyethyl-modified oligonucleotides Grant 6,673,912 - Manoharan , et al. January 6, 2 | 2004-01-06 |
Di-nitrogen heterocycle compositions Grant 6,660,466 - Cook , et al. December 9, 2 | 2003-12-09 |
Modified oligonucleotides Grant 6,653,458 - Manoharan , et al. November 25, 2 | 2003-11-25 |
Process for the synthesis of 2'-O-substituted pyrimidines and oligomeric compounds therefrom Grant 6,642,367 - Cook , et al. November 4, 2 | 2003-11-04 |
Aminooxy-modified nucleosidic compounds and oligomeric compounds prepared therefrom Grant 6,639,062 - Manoharan , et al. October 28, 2 | 2003-10-28 |
C3'-methylene hydrogen phosphonate oligomers and related compounds Grant 6,639,061 - Cook , et al. October 28, 2 | 2003-10-28 |
Method of using modified oligonucleotides for hepatic delivery App 20030191075 - Cook, Phillip Dan ;   et al. | 2003-10-09 |
2' -modified oligonucleotides App 20030187240 - Cook, Phillip Dan ;   et al. | 2003-10-02 |
Oligonucleotide analogs having modified dimers App 20030181693 - Cook, Phillip Dan ;   et al. | 2003-09-25 |
Derivatized oligonucleotides having improved uptake and other properties App 20030175751 - Manoharan, Muthiah ;   et al. | 2003-09-18 |
Compositions and methods for modulating RNA Grant 6,610,663 - Cook , et al. August 26, 2 | 2003-08-26 |
2'-O-aminoethyloxyethyl-modified oligonucleotides Grant 6,600,032 - Manoharan , et al. July 29, 2 | 2003-07-29 |
C3' -methylene hydrogen phosphonate oligomers and related compounds App 20030139586 - Cook, Phillip Dan ;   et al. | 2003-07-24 |
Guanidinium functionalized nucleotides and precursors thereof Grant 6,593,466 - Manoharan , et al. July 15, 2 | 2003-07-15 |
Alpha modified nucleoside triphosphates App 20030129615 - Wyrzykiewicz, Tadeusz ;   et al. | 2003-07-10 |
Guanidinium functionalized oligomers and methods App 20030092046 - Manoharan, Muthiah ;   et al. | 2003-05-15 |
Aminooxy-modified Nucleosidic Compounds And Oligomeric Compounds Prepared Therefrom App 20030088079 - MANOHARAN, MUTHIAH ;   et al. | 2003-05-08 |
Derivatized oligonucleotides having improved uptake and other properties App 20030064492 - Manoharan, Muthiah ;   et al. | 2003-04-03 |
Guanidinium functionalized oligonucleotides and method/synthesis Grant 6,534,639 - Manoharan , et al. March 18, 2 | 2003-03-18 |
Process for the synthesis of 2' -O-substituted pyrimidines and oligomeric compounds therefrom App 20030050454 - Cook, Phillip Dan ;   et al. | 2003-03-13 |
2'modified oligonucleotides Grant 6,531,584 - Cook , et al. March 11, 2 | 2003-03-11 |
Backbone modified oligonucleotide analogues App 20030045705 - Cook, Phillip Dan ;   et al. | 2003-03-06 |
Oligonucleotide-folate conjugates Grant 6,528,631 - Cook , et al. March 4, 2 | 2003-03-04 |
Compositions and methods for non-parenteral delivery of oligonucleotides App 20030040497 - Teng, Ching-Leou ;   et al. | 2003-02-27 |
Carbamate-derivatized nucleosides and oligonucleosides App 20030039977 - Cook, Phillip Dan ;   et al. | 2003-02-27 |
Nucleobase heterocyclic combinatorialization App 20030003505 - Cook, Phillip Dan | 2003-01-02 |
Sugar modified oligonucleotides App 20030004325 - Cook, Phillip Dan ;   et al. | 2003-01-02 |
Nucleotides having chiral phosphorus linkages Grant 6,500,945 - Cook December 31, 2 | 2002-12-31 |
Backbone-modified oligonucleotide analogs and methods for using same App 20020183502 - Mesmaeker, Alain De ;   et al. | 2002-12-05 |
Derivatized oligonucleotides having improved uptake and other properties App 20020177150 - Manoharan, Muthiah ;   et al. | 2002-11-28 |
Compositions and methods for modulating RNA App 20020160972 - Cook, Phillip Dan ;   et al. | 2002-10-31 |
Gapped 2' modified oligonucleotides App 20020160379 - Cook, Phillip Dan ;   et al. | 2002-10-31 |
Nucleoside derivatives as inhibitors of RNA-dependent RNA viral polymerase App 20020147160 - Bhat, Balkrishen ;   et al. | 2002-10-10 |
Oligonucleotides having chiral phosphorus linkages App 20020137921 - Cook, Phillip Dan | 2002-09-26 |
Sugar-modified gapped oligonucleotides Grant 6,451,991 - Martin , et al. September 17, 2 | 2002-09-17 |
Oligonucleotides having site specific chiral phosphorothioate internucleoside linkages Grant 6,440,943 - Cook , et al. August 27, 2 | 2002-08-27 |
Oligonucleotide analogs having modified dimers Grant 6,420,549 - Cook , et al. July 16, 2 | 2002-07-16 |
Sugar modified oligonucleotides Grant 6,399,754 - Cook June 4, 2 | 2002-06-04 |
Derivatized oligonucleotides having improved uptake and other properties Grant 6,395,492 - Manoharan , et al. May 28, 2 | 2002-05-28 |
Nucleosidic and non-nucleosidic folate conjugates App 20020049163 - Cook, Phillip Dan ;   et al. | 2002-04-25 |
Pyrimidine nucleosides Grant 6,369,040 - Acevedo , et al. April 9, 2 | 2002-04-09 |
Antisense inhibition of ras gene with chimeric and alternating oligonucleotides Grant 6,359,124 - Ecker , et al. March 19, 2 | 2002-03-19 |
Compositions and methods for modulating RNA Grant 6,358,931 - Cook , et al. March 19, 2 | 2002-03-19 |
Nucleobase Heterocyclic Combinatorialization App 20020009748 - COOK, PHILLIP DAN | 2002-01-24 |
Antisense oligonucleotides which have phosphorothioate linkages of high chiral purity and which modulate .beta.I, .beta.II, .gamma., .delta., .EPSILON., .zeta. and .eta. isoforms of human protein kinase C Grant 6,339,066 - Bennett , et al. January 15, 2 | 2002-01-15 |
Nucleosidic and non-nucleosidic folate conjugates Grant 6,335,434 - Guzaev , et al. January 1, 2 | 2002-01-01 |
Compounds having a plurality of nitrogenous substitutents Grant 6,329,523 - Cook , et al. December 11, 2 | 2001-12-11 |
Gapped 2' modified oligonucleotides Grant 6,326,199 - Cook , et al. December 4, 2 | 2001-12-04 |
Carbamate-derivatized nucleosides and oligonucleosides Grant 6,322,987 - Cook , et al. November 27, 2 | 2001-11-27 |
Methods of using mammalian RNase H and compositions thereof App 20010044145 - Monia, Brett P. ;   et al. | 2001-11-22 |
4-desmethyl nucleoside analogs and oligomers thereof Grant 6,320,040 - Cook , et al. November 20, 2 | 2001-11-20 |
Phosphorothioate oligonucleotides having modified internucleoside linkages App 20010027251 - Cook, Phillip Dan ;   et al. | 2001-10-04 |
Alkylation of alcohols, amines, thiols and their derivatives by cyclic sulfate intermediates Grant 6,277,982 - Fraser , et al. August 21, 2 | 2001-08-21 |
Thiol-derivatized nucleosides and oligonucleosides Grant 6,265,558 - Cook , et al. July 24, 2 | 2001-07-24 |
Oligonucleotides having chiral phosphorus linkages App 20010008936 - Cook, Phillip Dan | 2001-07-19 |
Compound for detecting and modulating RNA activity and gene expression Grant 6,262,241 - Cook , et al. July 17, 2 | 2001-07-17 |
Phosphorothioate oligonucleotides having modified internucleoside linkages Grant 6,242,589 - Cook , et al. June 5, 2 | 2001-06-05 |
Oligonucleotides having chiral phosphorus linkages Grant 6,239,265 - Cook May 29, 2 | 2001-05-29 |
Substituted purines and oligonucleotide cross-linking Grant 6,232,463 - Cook , et al. May 15, 2 | 2001-05-15 |
Process for the synthesis of 2'-O-substituted pyrimidines and oligomeric compounds therefrom Grant 6,222,025 - Cook , et al. April 24, 2 | 2001-04-24 |
Oligonucleoside linkages containing adjacent nitrogen atoms Grant 6,214,551 - Sanghvi , et al. April 10, 2 | 2001-04-10 |
PNA combinatorial libraries and improved methods of synthesis Grant 6,204,326 - Cook , et al. March 20, 2 | 2001-03-20 |
Aminooxy-modified oligonucleotides and methods for making same Grant 6,172,209 - Manoharan , et al. January 9, 2 | 2001-01-09 |
Oligomeric compounds having pyrimidine nucleotide (S) with 2'and 5 substitutions Grant 6,166,197 - Cook , et al. December 26, 2 | 2000-12-26 |
Carbamate-derivatized nucleosides and oligonucleosides Grant 6,166,188 - Cook , et al. December 26, 2 | 2000-12-26 |
N-2 substituted purines Grant 6,166,199 - Cook , et al. December 26, 2 | 2000-12-26 |
Antibacterial quinazoline compounds Grant 6,156,758 - Kung , et al. December 5, 2 | 2000-12-05 |
Derivatized oligonucleotides having improved uptake and other properties Grant 6,153,737 - Manoharan , et al. November 28, 2 | 2000-11-28 |
Antimicrobial determination of N-(aminoalkyl) and/or N-(Amidoalkyl) dinitrogen heterocyclic compositions Grant 6,150,129 - Cook , et al. November 21, 2 | 2000-11-21 |
2'-O-acetamido modified monomers and oligomers Grant 6,147,200 - Manoharan , et al. November 14, 2 | 2000-11-14 |
Gapped 2' modified oligonucleotides Grant 6,146,829 - Cook , et al. November 14, 2 | 2000-11-14 |
Process for the preparation of 2'-O-alkyl purine phosphoramidites Grant 6,133,438 - Cook , et al. October 17, 2 | 2000-10-17 |
2'-O-aminooxy-modified oligonucleotides Grant 6,127,533 - Cook , et al. October 3, 2 | 2000-10-03 |
Oligomeric compounds having nitrogen-containing linkages Grant 6,121,433 - Cook , et al. September 19, 2 | 2000-09-19 |
Thiol-derivatized oligonucleotides Grant 6,114,513 - Cook , et al. September 5, 2 | 2000-09-05 |
Carbamate-derivatized nucleosides and oligonucleosides Grant 6,111,085 - Cook , et al. August 29, 2 | 2000-08-29 |
Nitrogenous macrocyclic compounds Grant 6,107,482 - Cook , et al. August 22, 2 | 2000-08-22 |
Heteroatomic oligonucleoside linkages Grant 6,087,482 - Teng , et al. July 11, 2 | 2000-07-11 |
Pyrimidine nucleoside compounds and oligonucleoside compounds containing same Grant 6,060,592 - Acevedo , et al. May 9, 2 | 2000-05-09 |
2'-O-Dimethylaminoethyloxyethyl-modified oligonucleotides Grant 6,043,352 - Manoharan , et al. March 28, 2 | 2000-03-28 |
Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling Grant 6,025,482 - Cook , et al. February 15, 2 | 2000-02-15 |
2'-modified oligonucleotides Grant 6,005,087 - Cook , et al. December 21, 1 | 1999-12-21 |
Cyclobutyl oligonucleotide surrogates Grant 6,001,841 - Cook , et al. December 14, 1 | 1999-12-14 |
4'-desmethyl nucleoside analogs, and oligomers thereof Grant 5,998,603 - Cook , et al. December 7, 1 | 1999-12-07 |
Backbone modified oligonucleotide analogs and preparation thereof through radical coupling Grant 5,969,118 - Sanghvi , et al. October 19, 1 | 1999-10-19 |
Antisense inhibition of ras gene with chimeric and alternating oligonucleotides Grant 5,965,722 - Ecker , et al. October 12, 1 | 1999-10-12 |
Backbone modified oligonucleotide analogues Grant 5,965,721 - Cook , et al. October 12, 1 | 1999-10-12 |
Gapped 2' modified oligonucleotides Grant 5,955,589 - Cook , et al. September 21, 1 | 1999-09-21 |
2'-O-modified nucleosides and phosphoramidites Grant 5,914,396 - Cook , et al. June 22, 1 | 1999-06-22 |
Phosphate linked oligomers Grant 5,886,177 - Cook , et al. March 23, 1 | 1999-03-23 |
2'-O-modified oligonucleotides Grant 5,872,232 - Cook , et al. February 16, 1 | 1999-02-16 |
Peptide nucleic acid combinatorial libraries Grant 5,864,010 - Cook , et al. January 26, 1 | 1999-01-26 |
Process for the synthesis of 2'-O-substituted pyrimidines Grant 5,861,493 - Cook , et al. January 19, 1 | 1999-01-19 |
2'-modified oligonucleotides Grant 5,859,221 - Cook , et al. January 12, 1 | 1999-01-12 |
Gapped 2'-modified oligonucleotides Grant 5,856,455 - Cook January 5, 1 | 1999-01-05 |
Thiol-derivatized oligonucleosides Grant 5,852,182 - Cook , et al. December 22, 1 | 1998-12-22 |
Oligonucleotides having chiral phosphorus linkages Grant 5,852,188 - Cook December 22, 1 | 1998-12-22 |
PNA combinatorial libraries and improved methods of synthesis Grant 5,831,014 - Cook , et al. November 3, 1 | 1998-11-03 |
Substituted purines and oligonucleotide cross-linking Grant 5,811,534 - Cook , et al. September 22, 1 | 1998-09-22 |
Modified oligonucleotides Grant 5,808,023 - Sanghvi , et al. September 15, 1 | 1998-09-15 |
N-2 substituted purines in oligonucleotides Grant 5,808,027 - Cook , et al. September 15, 1 | 1998-09-15 |
Oligonucleoside linkages containing adjacent nitrogen atoms Grant 5,792,844 - Sanghvi , et al. August 11, 1 | 1998-08-11 |
Complex chemical libraries Grant 5,780,241 - Cook July 14, 1 | 1998-07-14 |
Heteroatomic oligonucleoside linkages Grant 5,777,092 - Cook , et al. July 7, 1 | 1998-07-07 |
Process for the synthesis of 2'-O-substituted pyrimidines Grant 5,760,202 - Cook , et al. June 2, 1 | 1998-06-02 |
Covalently cross-linked oligonucleotides Grant 5,719,271 - Cook , et al. February 17, 1 | 1998-02-17 |
Phosphoramidate and phosphorothiomidate oligomeric compounds Grant 5,717,083 - Cook , et al. February 10, 1 | 1998-02-10 |
PNA-DNA-PNA chimeric macromolecules Grant 5,700,922 - Cook December 23, 1 | 1997-12-23 |
Methods of making conjugated 4' desmethyl nucleoside analog compounds Grant 5,688,941 - Cook , et al. November 18, 1 | 1997-11-18 |
Substituted purines and oligonucleotide cross-linking Grant 5,681,941 - Cook , et al. October 28, 1 | 1997-10-28 |
Heteroatomic oligonucleoside linkages Grant 5,677,437 - Teng , et al. October 14, 1 | 1997-10-14 |
Sugar modified oligonucleotides that detect and modulate gene expression Grant 5,670,633 - Cook , et al. September 23, 1 | 1997-09-23 |
Oligonucleotides for modulating Ha-ras or Ki-ras having phosphorothioate linkages of high chiral purity Grant 5,661,134 - Cook , et al. August 26, 1 | 1997-08-26 |
Oligonucleotides for modulating RAF kinase having phosphorothioate linkages of high chiral purity Grant 5,654,284 - Cook , et al. August 5, 1 | 1997-08-05 |