U.S. patent number RE39,043 [Application Number 10/720,079] was granted by the patent office on 2006-03-28 for collagen production promoter composition.
This patent grant is currently assigned to Shiseido Company, Ltd.. Invention is credited to Nao Kojima, Yasukazu Nakayama.
United States Patent |
RE39,043 |
Nakayama , et al. |
March 28, 2006 |
Collagen production promoter composition
Abstract
A collagen production promoter composition according to the
present invention containing an extract from a shoot of a tree
belonging to the Fagaceae Fagus, particularly a young shoot, as an
active component, which exhibits a superior effect of prevention of
aging by promoting the production of collagen, which is one of the
components of the extracellular matrix, and the activation of the
excellular matrix and normalization of the skin tissue based on the
promotion of production of collagen.
Inventors: |
Nakayama; Yasukazu (Kanagawa,
JP), Kojima; Nao (Tokyo, JP) |
Assignee: |
Shiseido Company, Ltd. (Tokyo,
JP)
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Family
ID: |
26356519 |
Appl.
No.: |
10/720,079 |
Filed: |
November 25, 2003 |
Related U.S. Patent Documents
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Application
Number |
Filing Date |
Patent Number |
Issue Date |
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09155012 |
Sep 16, 1998 |
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Reissue of: |
09472438 |
Dec 27, 1999 |
06531165 |
Mar 11, 2003 |
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Foreign Application Priority Data
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Jan 17, 1997 [JP] |
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9-19673 |
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Current U.S.
Class: |
424/769; 424/779;
514/844; 424/725 |
Current CPC
Class: |
A61K
36/889 (20130101); A61K 36/49 (20130101); A61K
8/9789 (20170801); A61Q 17/04 (20130101); A61Q
1/12 (20130101); A61K 8/0212 (20130101); A61Q
19/08 (20130101); A61Q 1/02 (20130101); A61K
36/49 (20130101); A61K 2300/00 (20130101); A61K
36/889 (20130101); A61K 2300/00 (20130101); Y10S
514/844 (20130101) |
Current International
Class: |
A61K
36/00 (20060101) |
Field of
Search: |
;424/769,725,779
;514/844 |
References Cited
[Referenced By]
U.S. Patent Documents
Foreign Patent Documents
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686 999 |
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Aug 1996 |
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CH |
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2 753 374 |
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Mar 1998 |
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FR |
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2 7563 374 |
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Mar 1998 |
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FR |
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61-263908 |
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Nov 1986 |
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JP |
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7-53348 |
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Feb 1995 |
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JP |
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7-285846 |
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Oct 1995 |
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JP |
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10-59836 |
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Mar 1998 |
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JP |
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WO 97/31620 |
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Sep 1997 |
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WO |
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Other References
Fevier "Fagus Silvatica Extract"; Nature Extracts; 119 (3): 142-147
(Feb. 1993) XP-000343313. cited by examiner .
Pourrat et al.; "A Beech bud Extract"; Cosmetic & Toiletries;
110(8): 59-63 (Aug. 1995) XP-000879477. cited by examiner .
Database WPI; Week 9934; XP-002130741; JP 11-158054; Abstract.
cited by examiner .
Koichi; "Preparation for External Use for Skin"; Patent Abstracts
of Japan; vol. 1998;, No. 01; Jan. 30, 1998; JP 09-227397; Sep. 2,
1997; Abstract. cited by examiner .
Matsumoto, K., Fragr. J. 24(8): 81-84 (1996) JICST-EPlus Abstract.
cited by examiner .
Lawless, J, .The Illustrated Encylopedia of Essential Oils, The
Complete Guide to the Use of Oils in Aromatherapy and Herbalism,
Element Books Ltd., MA, p. 48, 1996. cited by examiner .
Hobbs, C., in "Handbook For Herbal Healing, A Concise Guide to
Herbal Products," Bontanica Press, Capitola, CA, pp. 16 and 23,
1995. cited by examiner .
Frawley et al., "The Yoga of Herbs, An Ayurvedic Guide to Herbal
Medicine," Lotus Press, WI, pp. 78-79, 1992. cited by
examiner.
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Primary Examiner: Tate; Christopher R.
Attorney, Agent or Firm: Foley & Lardner LLP
Parent Case Text
This application .Iadd.is a Reissue application of U.S. Ser. No.
09/472,438, filed Dec. 27, 1999, now U.S. Pat. No. 6,531,165,
granted Mar 11, 2003, which .Iaddend.is a divisional of application
Ser No. 09/155,012, filed Sep. 16, 1998.Iadd., now
abandoned.Iaddend..
Claims
What is claimed is:
1. A method for promoting collagen production in a fibroblast of a
subject comprising topically administering to said subject a
collagen production promoter composition in an amount effective to
promote collagen production in a fibroblast, wherein said
composition comprises, as active components, (i) 0.0001 to 30.0% by
weight, based upon the total weight of the composition, of an
extract obtained by extracting a shoot of Fagus crenata with at
least one solvent, wherein the advent is selected from the group
consisting of water, ethanol, methanol, propanol, butanol,
1,3-butylene glycol and any mixtures thereof, and (ii) .[.vitamin
C.]. .Iadd.a compound selected from the group consisting of
L-ascorbic acid, L-ascorbate dipalmitate esters, L-ascorbate
Monopalmitate esters, sodium L-ascorbate-2-sulfate, L-ascorbate
phosphate esters, L-ascorbate stearate esters,
L-ascorbate-2-glycoside or dipotassium
DL-.alpha.-tocopherol-L-ascorbate phosphate diester or mixtures
thereof .Iaddend.in an amount effective for synergistic promotion
of collagen production.
2. A method as claimed in claim .[.in.]. 1.Iadd., .Iaddend.wherein
the extract from a shoot of a Fagus crenata is contained in a range
of 0.0001 to 10.0% by weight based upon the total weight of the
composition. .Iadd.3. A method as claimed in claim 1, wherein the
compound is L-ascorbate-2-glycoside..Iaddend.
Description
TECHNICAL FIELD
The present invention relates to a collagen production promoter
composition for promoting the production of collagen, which is one
of the components of the extracellular matrix.
BACKGROUND ART
The shoots of plants are the stage before budding. In preparation
for the budding, large amounts of active ingredients such as plant
hormones am stored in the shoots. Medical treatments using these
highly active ingredients have been known in Europe since the 1960s
as "Gemmo-therapy".
On the other hand, subject, aging proceeds in all organs of the
body. However, looking at aging of the skin, which can be visually
discerned, especially the face, which people easily focus their
attention on, changes is appearance such as wrinkles and crow's
feet, stains and age spots, sagging, loss of tautness and gloss
trouble many of the middle aged and elderly in the world,
particularly women. Up until now, the need for an anti-aging
cosmetic has been pointed to, but since there was much about the
mechanism, definition, etc. of aging that had act been dear, in
conventional cosmetics, the method had been adopted of trying to
maintain moisture by adding biochemical product or synthetic
polymer product such as a mucopolysaccharide, collagen. However, it
became clearer that with this alone, it was not possible to
sufficiently prevent aging of the skin.
However, in recent years, there have been studies advanced on
aging. As the causes for aging of the skin, viewed macroscopically,
actual years has been an important factor. Further, drying,
oxidation, the effects of sunlight (UV rays), etc. have been
mentioned as direct factors relating to skin aging. Further, it has
become clear that, at the skin of the face, there is a remarkable
decline in the collagen fiber, which is the most important
component of the matrix of dermis. Further, it is suggested that
the occurrence of wrinkles and crow's feet and the lass of tautness
are closely related to the decline in the collagen fiber.
In this way, when it comes to aging of the skin, various skin aging
factors cause a decline in the proliferation of fibroblasts,
important cells in the dermis, and the capability to biosynthesize
collagen and the like, typical components of the extracellular
matrix in the skin, and consequently cause a slowdown in the speed
of turnover of the collages etc. As a result, the elasticity of the
skin is lost, wrinkles and sagging increase, and aging of the skin
progresses.
Under the above-mentioned circumstances, there has been a demand
for a collagen production promoter which promotes the biosynthesis
of collagen, which is one of the important components in the
dermis, so as to prevent aging of the skin and which is free from
problems in safety.
DISCLOSURE OF INVENTION
Accordingly, the object of the present invention is to provide a
collagen production promoter composition having an action promoting
biosynthesis of collagen, which is one of the important components
of the extracellular matrix of the skin, by acting on the
fibroblasts in the skin.
In accordance with the present invention, there is provided a
collagen production promoter composition comprising an extract from
a shoot of a tree belonging to Fagaceae Fagus, as an active
component, in a base component.
BRIEF DESCRIPTION OF THE DRAWINGS
The present invention will now be further explained with reference
to the drawing.
FIG. 1 is a view showing the relationship between an extract of a
shoot of a tree belonging to the Fagus crenata obtained in Test
Example 1 and the amount of production of PIP.
BEST MODE FOR CARRYING OUT THE INVENTION
The present invention now will now be explained in further
detail.
The extract from a shoot of a tree belonging to the Fagaceae Fagus
which an be used in the present invention is obtained from a shoot
of the Fagus crenata Blume, Fagus japonika Maxim, Fagus
grandifolia, Fagus sylvatica L., Fagus sylvatica L var. pendula,
Fagus sybatica L. var. purpurea, Fagus orientalus Lipsky, etc.
alone or in mixtures of two or more types. For the extraction,
solvents usually used at the time of production of a cosmetic
material such as water, ethanol, methanol, propanol, butanol,
1,3-butylene glycol are used alone or in any mixtures thereof. The
shoot of a tree belonging to the Fagus used in the present
invention is observed to be effective if it is the shoot part, but
the use of a young shoot is preferable because of higher
effectiveness.
Note that there have not been any reports regarding the action of
promotion of the production of collagen of an extract from a shoot
of a tree belonging to, the Fagaceas Fagus up to now.
As an extract from a shoot of the tree belonging to the Fagus of
the present invention, for example, GATULINE (registered trademark)
RC and GATULINE (registered trademark) R manufactured and marketed
by Gattfosse S. A. of France may be mentioned
For the collagen production promoter composition according to the
present invention, one or more types of extracts from shoots,
preferably young shoots, of these trees belonging to the Fagus can
be optionally selected.
The amount blended is preferably 0.0001 to 30.0% by weight, more
preferably 0.001 to 10.0% by weight, based upon the total amount of
the collagen production promoter composition.
The collagen production promoter composition of the present
invention promotes the production of collagen, which is one of the
components of the extracellular matrix, and achieves the desired
object purpose for exhibiting the superior effect of preventing
aging by activating the extra-cellular matrix and restoring the
skin tissue to normal based on the promotion of the production of
collagen.
Other medicinal ingredients may be formulated into the collagen
production promoter composition of the present invention so long as
they do not detract from the desired effect.
For example, to input a moisturizing effect etc., moisturizes such
as polyethylene glycol, propylene glycol, glycerin, 1,3-butylene
glycol, hexylene glycol, xylitol, sorbitol, maltitol, chondroitin
sulfuric acid, hyaluronic acid, mucoitin sulfuric acid, carouic
acid; atelocollagenous protein, cholesteryl-12-hydroxystearate,
sodium lactate, gallates, dl-pyrrolidone carboxylates, short chain
soluble collagenous protein, diglycerin (EO) PO adducts, Hestnut
rose (Rosa roxburghii) extract, Yarrow (Achilles millefolium)
extract, Sweet clover (Melilotus officinalis) extract, tranexamic
acid may be formulated into the collagen production promoter
composition of the present invention.
Giving a whitening effect is useful for the purpose of relieving
the harmful effects of UV rays, which is one of the major factors
behind skin aging, on the skin. In this case, whiteners such as;
placenta extract, glutathione, saxifrage extract, albutin may be
formulated into the collagen production promoter composition of the
present invention.
Giving an antiphlogistic effect is useful for the purpose of
relieving the harmful effects of UV rays on the skin in the same
way as above. 1n this case, antiphlogistic agents such as a
glycyrrhizic acid derivative, glycyrrhetic acid derivative,
salicylic acid derivative, hinokitiol, zinc oxide, allantoin may be
formulated into the collagen production promoter composition of the
present invention.
Similarly, for the purpose of relieving the harmful effects of UV
rays on the skin etc., activating agents such as royal jelly,
photosensitive agents, cholesterol derivatives, fetal calf serum
extract; blood circulation promoters such as nonylate valenyl
amide, nicotinate benzyl esters, nicotinate .beta.-butoxyethyl
esters, capsaicine, zingerone, cantharis tincture, ichthammol,
caffeine, tannic acid, .alpha.-borneol, tocopherol nicotinate,
inositol hexanicotinste, cyclandelate, cinnarizine, trazoline,
acetylcholine, verapaml, cepharanthine .gamma.-orzanol;
antiseborrheics such as sulfur, thianthol, etc. may be formulated
into the collagen production promoter composition of the present
invention.
Further, for the purpose of easing the adverse effect of UV rays on
the skin, a UV protective agent may be formulated into the collagen
production promoter composition of the present invention.
That is, as the P long wavelength UV ray (UVA) absorbers,
anthranilate base UV absorbers such as methyl anthranilate,
homomentyl-N-acetylanthranilate; benzophenone base UV absorbers
such as 2,4-dihydroxybenzophenone,
2,2-dihydroxy-4-methoxybenzophenone,
2,2'-dihydroxy-4,4'-dimethoxybenzophenone,
2,2',4,4'-tetrabydroxybenzophenone 2-hydroxy-4-methoxybenzophenone,
2-hydroxy-4-methoxy-4'-methylbenzenephenone,
2-hydroxy-4-methoxybenzephenone-5-sulfonic acid,
4-phenylbenzophenone,
2-ethylhexyl-4'-phenyl-benzophenone-2-carboxylate,
2-hydroxy-4-n-octoxybenzophenone, 4-hydroxy-3-carboxybenzophenone;
benzotriazole base UV absorbers such as
2,2'-hydroxy-5-methylphenylbenzotriazole,
2-(2'-hydroxy-5'-t-octylphenyl) benzotriazole,
2-(2'-hydroxy-5'-methylphenyl) benzotriazole; dianisoylmethane,
4-methoxy-4'-t-butyldibenzoylmethane etc. may be mentioned.
Among these UVA absorbers, 4-methoxy-4'-tert-butyldibenzoylmethane,
2-hydroxy-4-methoxybenzophenone, and
2-hydroxy-4-methoxybenzophenone derivatives, for example,
2-hydroxy-4-methoxy-benzophenone-5-sulfonates are those superior in
safety said effectiveness.
Further, as P medium wavelength UV ray (UVB) absorbers, benzoate
base UV absorbers such as paraaminobenzoic acid (hereinafter
referred to as "PABA"), PABA monoglycerin ester,
N,N-dipropoxy-PABA-ethyl ester, N,N-diethoxy-PABA ethyl ester,
N,N-dimethyl-PABA-ethyl ester, N,N-dimethyl-PABA-butyl ester,
N,N-dimethyl-PABA-amyl ester, salicylate base UV absorbers such as
dipropylene glycol salicylate, ethylene glycol salicylate, myristyl
salicylate, methyl salicylate, amyl salicylate, menthyl salicylate,
homomenthyl salicylatc, octyl salicylate, phenyl salicylate, benzyl
salicylate, p-isopropanolphenyl salicylate; cinnamate base UV
absorbers such as octyl cinnamate, ethyl-4-isopropyl cinnamate,
methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate,
methyl-2,4-diisopropyl cinnamate, -propyl-p-methoxy cinnamate,
isopropyl-p-methoxy cinnamate, isoamyl-p-methoxy cinnamate,
octyl-p-methoxy cinnamate (2-ethylhexyl-p-methoxy cinnamate),
2-ethoxyethyl-p-methoxy cinnamate, cyclohexyl-p-methoxy cinnamate,
ethyl-.alpha.-cyano-.beta.-phenyl cinnamate,
2-ethylhexyl-.alpha.-cyano-.beta.-phenyl cinnamate,
glycerylmono-2-ethythexanoyl-diparamethoxy cinnamate (or
mono-2-ethylyhexanoic glyceryl diparamethoxy cinnamate), octyl
methoxycinnamate, 3,4,5-trimethoxycianamate-3-methyl-4-[methylbis
(trimethylsiloxy)silyl]butyl, p-dimethoxycinnamate monoethyl
esters; camphor derivatives such as
3-(4'-methylbenzylidene)-d,1-camphor, 3-benzylidene-d,1-camphor,
5-(3,3-dimethyl-2-norbornylidene)-3-penten-2-one; urocanic acid,
urocanate ethyl, esters, 2-phenyl-5-methylbenzoxazolo,
dibenzalazine, etc. may be mentioned.
Further, as the UV scattering agents, titanium oxide (TiO.sub.2)
talc (MgSiO.sub.2), carmine (FeO.sub.2), bentonite; kaolin, zinc
oxide (ZnO), etc. may be mentioned.
Further, for various purposes, plant extracts such as phellodendron
bark extract, Japanese coptis extract, lithospermum root extract,
peony root extract, swertia herb extract, birch extract, sage
extract, loquat leaf extract, ginseng extract, aloe extract, mallow
extract, iris extract, grape extract, coix extract, sponge gourd
extract, lily extract, saffran extract, cnidium rhizome extract,
ginger extract, hypericum extract, restharrow extract, rosemary
extract, garlic extract, cayenne extract, citrus unshiu peel
extract, Japanese angelica root extract may be formulated into the
collagen production promoter composition of the present
invention.
Further, to further give the inherent effects of various vitamins
to the collagen production promoter composition of the present
invention, vitamin A's such as vitamin A oil, retinol, retinol
acetate; vitamin B.sub.2's such as riboflavin, riboflavin butyrate,
flavinadenine nucleotide; vitamin B.sub.6's such as pyridoxine
hydrochlorates, pyridoxine dioctanoates; vitamin C's such as
L-ascorbic acid, L-ascorbate dipalmilate esters, L -ascorbate
monopalmitate esters, sodium L-ascorbate-2-sulfate, L-ascorbate
phosphate esters, L-ascorbate stearate esters,
L-aseorbate-2-glycoside, dipotassium
DL-.alpha.-tocopherol-L-ascorbate phosphate diester; pantothenic
acids such as calcium pantothenate, D-pantothenyl alcohol,
pantothenyl ethyl ether, acetyl pantothenyl ethyl ether; vitamin
D's such as ergocalciferol, cholecalciferol; nicotinic acids such
as nicotinic acid, nicotinic acid amide, benzyl nicotinate; vitamin
E's such as .alpha.-tocopherol, tocopherol acetate,
DL-.alpha.-tocopherol nicotinate, DL-.alpha.-tocopherol succinate;
vitamin P, biotin, and other vitamins maybe formulated into the
collagen production promoter composition of the present
invention.
Among these vitamins, when vitamin C's such as L-ascorbic acid,
L-ascorbate dipalmilate esters, L-ascorbate monopalmitate esters,
sodium L-ascorbate-2-sulfate, L-ascorbate phosphate esters,
L-ascorbate stearate esters, L-ascorbate-2-glycoside, dipotassium
DL-.alpha.-tocopherol-L-ascorbate phosphate diester ate
incorporated into the collagen production promoter composition of
the present invention, a synergistic effect of promotion of the
production of collagen is observed.
Note that the other medicinal ingredients which may be. formulated
into the collagen production promoter composition of the present
invention are not limited to the above-mentioned medicinal
ingredients. Further, the corresponding medicinal effects of the
other medicinal ingredients mentioned above are not limited to The
above. For example, vitamin C's may be used as whitening components
and may also be used as anti-oxidation adjuvants. Further, the
medicinal components mentioned above may be formulated into the
collagen production promoter composition of the present invention
alone or two or more of the above medicinal components may be
optionally formulated in suitable combinations according to the
purpose.
The present invention can be applied to a wide range of cosmetics,
quasidrugs, etc. used for the external skin. It may take a broad
range of forms such as aqueous solutions, dissolvable systems,
emulsions, powders, oils, gels, ointments, aerosols, water-oil
two-phase systems, water-oil-powder three-phase: systems, etc. That
is, in the case of basic cosmetics, it may be applied in the above
various forms for facial cleansers, toilet water, emulsions,
creams, gels, essences (beauty lotions), packs, masks, and other
types of cosmetics. Further, if a makeup cosmetic, it may be used
for a wide range of types of cosmetics such as foundations while in
the case of a toiletry product it may be used for body soap, facial
soap, etc. Further, in the case of a quasidrug, it can be used for
a wide range of applications such as various ointments. Further,
the types of the collagen production promoter composition of the
present invention are not limited to these forms and types.
Further, the collagen production promoter composition of the
present invention acts on the area around the hair roots and the
scalp and is affective in protecting the scalp, and therefore, can
be used also as, for example, a shampoo, rinse, treatment,
conditioner, or other hair product.
In the Collagen production promoter composition of the present
invention, it tat possible to formulate in a broad range of the
usual (mown base components depending upon the above desired form
and type to an extent where this formulation does not impair the
desired effect of the present invention.
That is, as a liquid oil, avocado oil, tsubaki oil, primrose oil,
turtle oil, macademia nut oil, corn oil; mink oil, olive oil,
rapeseed oil, egg oil, sesame oil, persic oil, wheat germ oil,
sasanqua oil, castor oil linseed oil, safflower oil, cottonseed
oil, perilla oil, soybean oil, peanut oil, teaseed oil, kaya oil
rice bran oil, China wood oil, Japanese wood oil, jojoba oil, germ
oil, triglycerin, glycerin trioctanate, glycerin triisopalmitate,
etc., as the solid oils and fats, cacao butter, coconut oil, horse
fat, hydrogenated coconut oil, palm oil beef tallow, sheep fat,
hydrogenated tallow, palm kernal oil hog fat, beef bone fat, Japan
wax out oil, hydrogenated oil, beef hoof fat, Japan was,
hydrogenated castor oil, etc., as the waxes, beeswax, candrlilla
wax, cotton wax, carnauba wax, bayberry wax, insect wax,
spermaceti, montan wax, rice bran wax, lanolin, kapok wax, lanolin
acetate, liquid lanolin, sugarcane wax, isopropyl lanolin fatty
acid, hexyl laurate, hydrogenated lanolin, jojoba wax, hard
lanolin, shellac wax, POE lanolin alcohol ether, POE lanolin
alcohol acetate, POE cholesterol other, polyethylene glycol lanolin
fatty acid, POE hydrated lanolin alcohol ether, etc., and as the
hydrocarbon oils, liquid paraffin, ozokerite, squalane, pristane,
paraffin, ceresine, squalene, vaseline, microcrystaltine wax, and
other oils may be mentioned.
As a higher fatty acrid, for example, lauric acid, myristic acid,
palmitic acid, stearic acid, bebenic acid, oleic acid,
12-hydroxystearic acid, undecylic acid, toluic acid, isostearic
acid, linolic acid, linoleic acid, eicosapentaenoic acid (EPA),
docosahexaenoic acid (DHA), etc. may be mentioned.
As a higher alcohol for example, linear alcohols such as lauryl
alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol myristyl
alcohol, oleyl alcohol, cetostearyl alcohol; and branched alcohols
such as monostearyl glycerin ether (batyl alcohol),
2-decyltetradecinol, lanolin alcohol, cholesterol phytosterol
hexyldodecanol, isostearyl alcohol, octyldecanol etc. may be
mentioned.
As synthetic ester oils, isopropyl myristate, cetyl octanate,
octyldadecyl myristate, isopropyl palmitate, butyl stearate, hexyl
laurate, myristyl myristate, decyl oleate, hexyldecyl
dimethyloctanate, cetyl lactate, myristyl lactate, lanolin acetate,
isocetyl stearate, isocetyl isostearate, cholesteryl
12-hydroxystearate, ethylene glycol di-2-ethylhexylate,
dipentaerythritol, fatty acid ester, N-alkylglycol monoisostearate,
neopentylglycol dicaproate, diisostearyl malate, glycerin
di-2-heptyl undecanoate, trimethylopropane tri-2-ethylhexylate,
trimethylopropane triisostearate, pentanerythritol
tetra-2-ethylhoxylate, glycerin tri-2-ethylhexylate,
trimethylopropane triisostearate, cetyl-2-ethylhexanoate,
2-ethylhexyl palmitate, glycerin trimyristate, glyceride
tri-2-heptylundecanoate, castor oil fatty acid methyl ester, oil
oleate, cetostearyl alcohol, acetoglyceride, 2-heptylundecyl
palmitale, diisobutyl adipate, N-lauroyl-L-glutamate-2-octyl
dodecyl ester, di-2-heplylundecyl adipate, ethyl laurate,
di-2-ethylhexyl sebatate, 2-hexyldecyl myristate, 2-hexyldecyl
palmitate, 2-hexyldecyl adipate, diisopropyl sebatate, 2-ethylhexyl
succinate, ethyl acetate, butyl acetate, amyl acetate, triethyl
citrate, etc. may be mentioned.
As silicones, linear polysiloxanes such as dimethyl polysiloxane,
methylphenyl polysiloxane, methylhydrogen polysiloxane, cyclic
polysiloxanes such as decamethyl polysiloxane, dodecamethyl
polysiloxane, tetramethyltetrahydrogen polysiloxane, silicone
resins forming 3 dimensional net structures, silicone rubber, etc.
may be mentioned.
As anionic surfactants, for example, fatty acid soaps such as soap
ingredients, sodium laurate, sodium palmitale; higher alkyl sulfate
eater salts such as sodium laurosulfate, potassium laurosulfate;
alkyl ether sulfate ester salts such as POE laurosulfate triethanol
amine, sodium POE laurosulfate; N-acylsarcosine acids such as
sodium lauroyl sarcosinate; higher fatty acid amide sulfonates such
as sodium N-myristoyl-N-methyl taurine, sodium N-eocoyl-N-methyl
taurid, sodium laurylmethyl taurid; phosphate ester salts such as
sodium POE oleyl ether phosphate, POE stearyl ether phosphate;
sulfosuccinates such as sodium di-2-ethylhexylsolfosuccinate,
sodium monolauroylmonoethanol amide polyoxyethylene sulfosuccinate,
sodium laurylpolypropylene glycol sulfosuccinate;
alkylbenzensulfonates such as linear sodium dedecylbenzensulfonate,
linear dodecylbenzensulfonate triethanol amine, linear dodecyl
benzensulfate; N-acyl glutamates such as monosodium N-lauroyl
glutamate, disodium N-stearoyl glutamate, monosodium N-myristoyl-L
-glutamate; higher fatty acid ester sulfate ester salts such as
sodium hydrogenated glyceryl cocoate sulfate; sulfated oils such as
Turkey red oil; POE alkyl ether carboxylic acid, POE alkylaryl
ether carboxylate, .alpha.-olefinsulates, higher fatty acid ester
sulfonates, secondary alcohol sulfate ester salts, higher fatty
acid alkylolamide sulfate ester salts, sodium lauroyl
monoethanolamide succinate, N-palmitoyl asparaginate ditriethanol
amine, sodium caseine, etc, may be mentioned.
As cationic surfactants, for example, alkyl trimethyl ammonium
salts such as stearyl trimethyl ammonium chloride, lauryl trimethyl
ammonium chloride; alkyl pyridinium salts such as distearyldimethyl
ammonium chloride, dialkyldimethyl ammonium chloride salts,
poly(N,N'-dimethyl-3,5-methylenepipcridinium)chloride,
cetylpyridinium chloride; alkyl quaternary ammonium salts, alkyl
dimethylbenzyl ammonium salts, alkyl isoquinolinium salts, dialkyl
morphoium salts, POE alkyl amines, alkyl amine salts, polyamine
fatty acid derivatives, amyl alcohol fatty acid derivatives,
bcnzalkonium chloride, benzethonium chloride, etc. may be
mentioned.
As amphoteric surfactants, for example, imidazoline base amphoteric
surfactants such as sodium 2-undecyl
-N,N,N-(hydroxyethylcarboxymethyl)-2-imidazoline,
2-cocoyl-2-imidazoliniumhydroxide-1-carboxyethyloxy-2-sodium salt;
betaine base surfactants such as
2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine,
lauryldimethyl-aminoacetate betaine, alkyl betaine, amide betaine,
sulfo betaine; etc. may be mentioned.
As lyophilic nonionic surfactants, for example, sorbitan fatty acid
esters such as sorbitan monooleate, sorbitan mono isostearate,
sorbitan monolaurate, sorbitan monopalmitate, sorbitan
monostearate, sorbitan sesquioleate, sorbitan trioleate, diglyceryl
sorbitan penta-2-ethylhexylate, diglyccryl sorbitan
tetra-2-ethylhexylate; glyceryl polyglyceryl fatty acids such as
glyceryl monocottonseed fatty acid, glyceryl monoerucate, glyceryl
sesquioleate, glyceryl monostearate, glyceryl
.alpha.,.alpha.-oleate pyroglutamate, glyceryl monostearate malate;
propylene glycol fatty acid esters such as propylene glycol
monostearate; hydrogenated castor oil derivatives, glyceryl alkyl
ethers, polyoxyethylene methylpolysiloxane copolymers, etc. may be
mentioned.
As hydrophilic nonionic surfactants, for example, POE sorbitan
fatty acid esters such as POE sorbitan monooleate, POE-sorbitan
monostearate,POE-sorbitan monooleate, POE-sorbitan tetraoleate; POE
sorbite fatty acid esters such as POE-sorbite monolaurate,
POE-sorbite monooleate, POE-sorbite pentaoleate, POE-sorbite
monostearate; POE glyceryl fatty acid eaters such as POE-glyceryl
monostearate, POE-glyceryl monoisostearate, POE-glyceryl
triisostearate; POE fatty acid eaters such as POE monooleate, POE
distearate, POE monodioleate, distearate ethylene glycol; POE alkyl
ethers catch as POE lauryl ethers, POE oleyl ethers, POE stearyl
ethers, POE behenyl ethers, POE2-octyldodecyl ethers, POE
cholestanol ethers; POE alkyl phenyl ethers such as POE octyl
phenyl ethers, POE nonyl phenyl ethers, POE dinonyl phenyl ethers;
pluaronics such as Plironic; POE-POP alkyl ethers such as POE.POP
cetyl ethers, POE. POP-2-decyltetradecyl ethers, POE.POP monobutyl
ethers, POE-POP hydrated lanolin, POP-POP glycerin ethers;
tetra-POE-tetra-POP ethylene diamine condensation products such as
Tetronic; POE castor oil hydrogenated castor oil derivatives such
as POE castor oil, POE hydrogenated castor oil, POE hydrogenated
castor oil monoisostearate, POE hydrogenated castor oil
triisostearate, POE hydrogenated castor oil monopyroglutamate
monoisostearate diester, POE hydrogenated castor oil maleate; POE
beeswax lanolin derivatives such as POE sorbitol beeswax;
alkanolamides such as coconut oil fatty acid diethanolamide, lauric
acid monoethanolamide, fatty acid isopropanolamide; POI: propylene
glycol fatty acid esters, POE alkylamines, POE fatty acid amides,
sucrose fatty acid esters, POE nonylphenyl formaldehyde
condensation products, alkylethoxdilimethylamineoxide,
trioley1phosphoric acid etc. may be mentioned.
As preservatives, methylparaben, ethylparabene, butylparaben, etc.
may be mentioned.
As metal ion chelates, sodium edetate salts, EDTA, etc. may be
mentioned.
As natural water-soluble polymers, plant base polymers such as gum
arabic, tragacanth gum, galacian, guar gum, carob gum, karaya gum,
carragbeein, pectin, agar, quince seed (Marumero) algae colloid
(seaweed extract), starch (rice, corn, potato, wheat), glycyrrhinic
acid; microorganism base polymers such as xanthane gum, dextran,
succinoglutan, pullulan; animal base polymers such as collagen,
caseine, albumin, gelatin; etc. may be mentioned.
As synthesized water-soluble polymers, starch base polymers such as
carboxymethyl starch, methythydroxypropyl starch; cellulose base
polymers such as methyl cellulose nitro cellulose, ethyl cellulose,
methythydroxypropyl cellulose, hydroxyethyl cellulose, sodium
cellulose sulfate, hydroxypropyl cellulose, sodium carboxymethyl
cellulose (CMC), crystalline cellulose, cellulose powder; alginate
base polymers such as sodium alginate, alginate propylene glycol
esters; etc. may be mentioned.
As synthesized water-soluble polymers, vinyl base polymers such as
a polyvinyl alcohol, polyvinylmcthyl ether, polyvinylpyrrolidone
carboxyvinyl polymer (Carbopol), alkyl modified carboxyvinyl
polymer, polyoxyethylene base polymers such as polyethylene glycol
2000, 4000, 6000; acryl base polymers such as polyoxyethylene
polyoxypropylene copolymer brae polymer, sodium polyacrylate,
polyethylene acrylate, polyacryl amide, polyethylene imine,
cationic polymer, etc. may be mentioned.
As inorganic water-soluble polymers, bentonite, AfMg silicate (bee
gum), laponite, hectonite, inorganic silicic acid, etc. may be
mentioned.
As the thickeners, carragheenin, karaya gum, tragacanth gum, carob
gum, quince seed (Marumero), caseine, dextrin, gelatin, sodium
pectinate, sodium alginate, methylcellulose, ethylcellulose, CMC,
hydroxyethylcellulose, hydroxypropylcellulose, PVA, PVM, PVP,
sodium polyacrylate, carboxyvinyl polymer, loqust bean gum, guar
gum, tamarind gum, dialkyldimethyl ammonium sulfate cellulose,
xanthane gum, aluminum magnesium silicate, bentonite, hectonite,
etc. may be mentioned.
As powder components, inorganic powders such as talc, kaolin, mica,
sericite, dolomite, phlogopite, synthetic mica, lepidolite,
biotite, lithis mica, vermiculite, magnesium carbonate, calcium
carbonate, aluminum silicate, barium silicate, calcium silicate,
magnesium silicate, strontium silicate, metal salts of tungstenic
acid, magnesium, silica, zeolite, barium sulfate, sintered calcium
sulfate (sintered gypsum), calcium phosphate, fluorapatite,
hydroxyapatite, ceramic powder, metal soap (zinc myristate, calcium
palmitate, ammonium stearate), boronitride; organic powders such as
polyamide resin powder (nylon powder), polyethylene powder, methyl
polymethacrylate powder, polystyrene powder, styrene and acrylic
acid copolymer resin powder, benzoguanamia resin powder,
polytetrafluoroethylene powder, cellulose powder, inorganic white
pigments such as titanium dioxide, zinc oxide; inorganic red
pigments such as iron oxide (bengara), iron titanate; inorganic
brown pigments such as y-iron oxide; inorganic yellow pigments such
as yellow iron oxide, yellow earth; inorganic blade pigments such
as black iron oxide, carbon black, lower titanium oxide; inorganic
violet pigments such as mango violet, cobalt violet; inorganic
green pigments such as chromium oxide, chromium hydroxide, cobalt
titanate; inorganic blue pigments such as prussian blue,
ultramarine; pearl pigments such as titanium oxide coated mica,
titanium oxide coated bismuth oxichloride, titanium oxide coated
talc, colored titanium oxide coated mica, bismuth oxichloride, fish
scales; metal powder pigments such as aluminum powder, copper
powder; lakes such as Libol rubine B (Rest No. 201), Lithol rubine
BCA (Red. No. 202), Lake red CBA (Red No. 204), Lithol red (Red No.
205), Deep maroon (Red No. 220), Helidone pink CN (Red No. 226),
Permatone Red (Red No. 228), Permanent red FSR (Red No. 405),
Permanent orange (Orange No. 203), Benzidine Orange (Orange No.
204), Benzidine Yellow G (Yellow No. 205), Hanza Yellow (Yellow No.
401), Blue No. 404; zirconium, barium, or aluminum lakes and other
lakes such as Erythrosine (Red No. 3), Phloxine B (Red No. 104),
Acid red (Red No. 106), Fast acid magenta (Red No. 227), Eosine YS
(Red No. 230). Violamine R (Red No. 401), Oil red XO (Red No. 505),
Orange II (Orange No. 205), Tartrazine (Yellow No. 4), Sunset
yellow FCF (Yellow No. 5), Uranine (Yellow No. 202), Quinoline
yellow (Yellow No. 203), Fast green FCF (Green No. 3), Brilliant
blue FCF (Blue No. 1); natural colors such as chlorophyl,
.beta.-carotin, coloring agents such as perfumes, water, alcohol,
titanium yellow, carmine, Safflower Red; etc. may also be suitably
formulated into the collagen production promotes composition of the
present invention, if necessary.
EXAMPLES
The present invention will now be explained in further detail with
reference to Examples, which by no means limits the present
invention. Note that before these Examples, the methods of testing
the effects and the results thereof will be explained.
(1) Test Example 1
(Evaluation of Action on Type I Collagen Producing Ability of Human
Skin Fibroblast)
Human skin fibroblasts (hereinafter referred to as "cells") were
used to evaluate the action of an extract of a shoot of a tree of
the Fagacase Fagus on the type I collagen biosynthesizing ability
of cells. That is, 20,000 cells/well were inoculated in a 96-well
plate (Corning: 25860) for cell culture. This was cultured in a
RITC80-7 medium containing 10% fetal bovine serum (hereinafter
referred to as "FBS") for 48 hours, then the medium was replaced
with a RITC80-7 medium containing 0.5% FBS (hereinafter referred to
as the "medium"). At this time, GATULINE (registered trademark) R
(made by Gattfosse S. A.) was added to the medium. The
concentrations of the GATULINE (registered trademark) R were made
0.015 and 0.1%. The medium was replaced with a medium containing
GATULINE (registered trademark) R, then the cells were cultured for
48 hours. After die: end of the culture, the cells of the culture
supernatant were sampled for measurement of the amount of cells for
measuring the type I collagen biosynthesis ability.
The type I collagen biosynthesis ability of the cells was evaluated
by measuring the amount of Procollagen type IC-peptide (PIP)
secreted into the culture supernatent. Specifically, this was
measured using a "Procollagen type IC-peptide (PIP) measurement kit
(made by Takara Shuzo KK: MK001).
The amount of cells was estimated by the amount of DNA of the
cells. The amount of DNA was measured using a Hoechst 33258 reagent
according to the method of Cesar Labarca et al. (Analytical
Biochemistry, 102, 344-352 (1980)).
The results are shown in FIG. 1. The amount of PIP increased
according to the concentration of the extract from the shoot of the
Fagus crenate. At 0.1%, a significant increase was observed. As
explained above, the extract of the shoot of the Fagus crenate was
observed to have the effect of promoting the type I collagen
biosynthesis ability without affecting the proliferation of cells
al extremely low concentrations of 0.01 to 0.1%.
(2) Test Example: 2
(Monitor Test)
The following test of use was performed on creams obtained in
Example 1 and Comparative Example 1 of the formulations shown in
Table 1. The amounts formulated an shown in % by weight. The
results are shown in Table 2.
TABLE-US-00001 TABLE 1 Comp. Ex. Ex. 1 1 (1) Cetostearyl alcohol
3.5 3.5 (2) Squalane 40.0 40.0 (3) Beeswax 3.0 3.0 (4) Hydrogenated
lanolin 4.0 4.0 (5) Ethylparaben 0.3 0.3 (6) Polyoxyethylene (20)
2.0 2.0 sorbitan monopalmitate ester (7) Monoglyceride stearate 2.0
2.0 (8) GATULINE (registered 0.5 -- trademark) RC (9) Sodium
N-stearoyl 0.5 0.5 glutaminate (10) Perfume 0.03 0.03 (11)
1,3-butylene glycol 5.0 5.0 (12) Polyethylene glycol 1500 5.0 5.0
(13) Purified water Balance Balance
Process of Production
The ingredients (1) to (10) shown in the above Table 1 were
dissolved under heating (oil phase). On the other hand (11) and
(12) were dissolved in purified water (13) and held at 70.degree.
C. (aqueous phase). The oil phase was added to the aqueous phase
while stirring, Next, the emulsion was processed by a homomixer to
reduce the emulsion granules it size, then stirred, then rapidly
cooled with stirring, to obtain the desired cream.
Test Method
Eighty healthy adult women of ages 35 to 68 extracted a random were
used as teat subjects. They were asked to us the cosmetics on the
skin of their faces daily for one month then aloe effect of
improvements in the tautness and sagging of the skin and the effect
of improvement of wrinkles and crow's feet were investigated.
Effect of Improvement of Tautness of Skin
The state of the skin was observed visually and evaluates based on
the following evaluation criteria.
(Evaluation Criteria) A: Extremely improved B: Improved C: No
change D: Became somewhat noticable E. Became noticable
Effect of Improvement of Wrinkles and Crow's Feet
The sate of the skin was observed visually and evaluated based on
the following evaluation criteria.
(Evaluation Criteria) A: Completely disappeared B: Somewhat reduced
C: No change D: Slightly increased E: Increased
TABLE-US-00002 TABLE 2 Effect on tautness Effect on large and
sagging wrinkles and crow's (persons) feet (persons) A B C D E A B
C D E Ex. 1 50 19 11 0 0 36 34 10 0 0 Comp. Ex. 1 2 12 63 2 1 1 9
67 3 0
As clear from thee results shown in Table 2, in the case of use of
the cosmetic obtained in Example. 1, a remarkable improvement was
observed in the tautness and sagging of the skin and there was an
extremely high effect with reaped to the wrinkles and crow's feet
compared with the case of use of the cosmetic obtained in
Comparative Example 1
Example 2
Cream
TABLE-US-00003 Formulation wt % Stearic acid 2.0 Stearyl alcohol
7.0 Hydrogenated lanolin 2.0 Squalane 5.0 2-octyldodecyl alcohol
6.0 Polyoxyethylene (25 mol) 3.0 cetyl alcohol ether Glyceryl
monostearate ester 2.0 Propylene glycol 5.0 Ethanol extract
containing shoot 5.0 of Fagus crenata Tranexamic acid 0.2
Ethylparaben 0.3 Perfume q.s. Ion exchange water Bal.
Process of Production
The propylene glycol was added to the ion exchange water, then the
mixture was heated and held at 70.degree. C. (aqueous phases). The
other ingredients were mixed and heated to melt, then the resultant
mixture was held at 70.degree. C. (oil phase). The oil phase was
added to the aqueous phase and preliminarily emulsified and then
emulsified uniformly by a homomixer, them the resultant mixture was
rapidly cooled to 30'C. while stirring well.
Example 3
Cream
TABLE-US-00004 Formulation wt % Solid paraffin 5.0 Beeswax 10.0
Vaseline 15.0 Liquid paraffin 41.0 Glyceryl monostearate ester 2.0
Polyoxyethylene (20 mol) 2.0 sorbitan monolaurate ester Soap powder
0.1 Acetone extract of young shoot 0.05 of Fagus crenata Sodium
bisulfite 0.03 Ethylparaben 0.3 Perfume q.s. Ion exchange water
Bal.
Process of Production
The soap powder was aged to the ion exchange water and heated and
held at 70.degree. C. (aqueous phase). The other ingredients were
mixed and heated to melt, then held at 70.degree. C. (oil phase).
The oil phase was gradually added to the aqueous phase while
stirring for the reaction. Alter the end of the reaction, the
resultant mixture was uniformly emulsified by a homomixer. After
the emulsification, the resultant mixture was cooled to 30.degree.
C. while stirring.
TABLE-US-00005 Formulation wt % Stearic acid 2.5 Cetyl alcohol 1.5
Vaseline 5.0 Liquid paraffin 10.0 Polyoxyethylene (10 mol) 2.0
monooleate ester Polyethylene glycol 1500 3.0 Triethanolamine 1.0
Carboxyvinyl polymer (brandname: Carbopol 0.05 941, B. F. Goodrich
Chemical Co.) GATULINE (registered trademark) R 0.01 Sodium
bisulfite 0.01 Ethylparaben 0.3 Perfume q.s. Ion exchange water
Bal.
Process of Production
The carboxyvinyl polymer was dissolved in a small amount of ion
exchange water (phase A). Polyethylene glycol 1500 and
triethanolamine were added to the remaining ion exchange water,
heated to melt, and held at 70'C. (aqueous phase). The rest of the
ingredients were mixed and heated to melt, then held at 70.degree.
C. (oil phase). The oil phase was added to the aqueous phase and
preliminarily emulsified, then the phase A was added and the
mixture homogeneously emulsified by a homomixer. After the
emulsification, the resultant mixture was cooled to 30.degree. C.
while stirring well.
Example 5
Emulsion
TABLE-US-00006 Formulation wt % Microcrystalline wax 1.0 Beeswax
2.0 Lanolin 20.0 Liquid paraffin 10.0 Squalane 5.0 Sorbitan
sesquioleate ester 4.0 Polyoxyethylene (20 mol) sorbitan 1.0
monooleate ester Propylene glycol 7.0 Butanol extract of shoot of
10.0 Fagus crenata Tranexamic acid 1.0 Sodium bisulfite 0.01
Ethylparaben 0.3 Perfume q.s. Ion exchange water Bal.
Process of Production
The propylene glycol was added to the ion exchange water and then
heated and held at 70" C. (aqueous phase). The rest of the
ingredients were mixed and heated to melt then held at 70.degree.
C. (oil phase). The oil phase was gradually added to the aqueous
phase while stirring and the two then homogeneously emulsified by a
homomixer. After emulsification, the emulsion was cooled to
30.degree. C. While stirring well.
Example 6
Jelly
TABLE-US-00007 Formulation wt % 95% ethyl alcohol 10.0 Dipropylene
glycol 15.0 Polyoxyethylene (50 mol) 2.0 oleyl alcohol ether
Carboxyvinyl polymer (brandname: Carbopol 0.05 940, B. F. Goodrich
Chemical Co.) Caustic soda 0.15 L-arginine 0.1 Methanol aqueous
solution extract of 0.001 young shoot of Fagus crenata Sodium
bisulfite 0.01 Ethylparaben 0.3 Perfume q.s. Ion exchange water
Bal.
Process of Production
The Carbopol 940 was homogeneously dissolved in the ion exchange
water. Go the other hand, the methanol aqueous solution extract of
the young shoot of Fagus crenata and polyoxyethylene (50 more oleyl
alcohol ether were dissolved in 95% ethanol and added to the
aqueous phase. Next, the rest of the ingredients were added, then
the resultant mixture was neutralized and thickened by the caustic
soda and L-arginine.
Example 7
Jelly
TABLE-US-00008 Formulation wt % (Phase A) Ethyl alcohol (95%) 10.0
Polyoxyethylene (20 mol) octyldodecanol 1.0 Pantothenyl ethyl ether
0.1 1,3-butylene glycol extract of young 1.5 shoot of Fagus crenata
Ethylparaben 0.15 (Phase B) Potassium hydroxide 0.1 (Phase C)
Glycerin 5.0 Dipropylene glycol 10.0 Sodium bisulfite 0.03
Carboxyvinyl polymer (brandname: Carbopol 0.2 940, B. F. Goodrich
Chemical Co.) Purified water Bal.
Process of Production
Phase A and Phase C were each homogeneously dissolved, the Phase A
was added to Phase C to solubilize it. Next, Phase B was added,
then the resultant mixture filled into containers.
Example 8
Pack
TABLE-US-00009 Formulation wt % (Phase A) Dipropylene glycol 5.0
Polyoxyethylene (60 mol) 5.0 hydrogenated castor oil (Phase B)
Acetone extract of shoot of 0.01 Fagus crenata Olive oil 5.0
Tocopherol acetate 0.2 Ethylparaben 0.2 Perfume 0.2 (Phase C)
Sodium bisulfite 0.03 Polyvinyl alcohol (saponification value 13.0
90, polymerization degree 2,000) Ethanol 7.0 Purified water
Bal.
Process of Production
Phase A, Phase B, and Phase C were each homogeneously dissolved,
then Phase B were added to Phase A to solubilize it. Next, this was
added to Phase C, then the resultant mixture filled in
containers.
Example 9
Sunburn Prevention Cosmetic
TABLE-US-00010 Formulation wt % Stearic acid 1.5 Cetyl alcohol 3.0
Beeswax 2.0 Polyoxyethylene (10 mol) monooleate 1.0 ester Glyceryl
monostearate ester 1.0 Dimethyl polysiloxane 10.0 Decamethyl
cyclopentasiloxane 20.0 2-hydroxy-4-metoxybensophenon 3.0
Octyl-p-methoxycinnamate 2.0 GATULINE (registered trademark) R 0.1
Perfume q.s. Ion exchange water Bal.
Example 10
Cosmetic Foundation
A W/O emulsion type cosmetic foundation of the following
composition was prepared:
TABLE-US-00011 Formulation wt % Organic modified monimorillonite
0.5 Cetyl isooctanate 2.0 Octamethyl cyclotetrasiloxane 2.0
Decamethyl cyclopentasiloxane 5.0 Dimethyl polysiloxane (6 cg) 5.0
Liquid paraffin 3.0 Dioctadecyldimethyl ammonium chloride 0.2
Polyoxyalkylene modified 5.0 organopolysiloxane
4-t-butyl-4'-methoxydibenzoylmethane 0.3 Glyceryl mono-2
ethylhexanoyldipara- 1.0 methoxycinnamate Microgranular titanium
oxide 5.0 Oleyl alcohol 0.5 Stearic acid 0.5 Sorbitan diisostearate
4.0 Antioxidant q.s. Perfume q.s. Talc 1.5 Nylon powder 1.0 Ion
exchange water Bal. Sodium citrate 0.5 1,3-butylene glycol 5.0
GATULINE (registered trademark) RC 0.01
Example 11
Powdery Foundation
TABLE-US-00012 Formulation wt % Microgranular titanium oxide 7.0
Talc 40.0 Mica Bal. Nylon powder 10.0 Red iron oxide 1.0 Yellow
iron oxide 2.0 Black iron oxide 0.2 Dimethyl polysiloxane 1.0
2-ethylhexyl palmitate 9.0 Sorbitan sesquioleate 1.0 N,N-dimethyl
PABA octyl ester 0.3 Ethyl acetate ester extract of shoot 5.0 of
Fagus crenata Preservative q.s. Antioxidant q.s. Perfume q.s.
Example 12
Oily Foundation
TABLE-US-00013 Formulation wt % Microgranular titanium oxide 10.0
Mica 22.4 Kaolin 10.0 Nylon powder 5.0 Red iron oxide 0.5 Yellow
iron oxide 2.0 Black iron oxide 0.1 Liquid paraffin Bal.
Dimethylpolysiloxane 10.0 Sorbitan sesquioleate 2.0
Octylmethoxycinnamate 5.0 Extract of shoot belonging 0.005 to Fagus
crenata Perfume q.s. Microcrystalline wax 6.0 Carnauba wax 3.0
INDUSTRIAL APPLICABILITY
As explained above, the collagen production promoter composition of
the present invention exhibits a superior effect of prevention of
aging by promoting the production of collagen, which is one of the
components of the extracellular matrix, and the activation of the
excellular matrix and normalization of the skin tissue based on the
promotion production of collagen.
* * * * *