U.S. patent number 3,917,063 [Application Number 05/367,437] was granted by the patent office on 1975-11-04 for packages enabling the extemporaneous preparation of suspensions or sterile solutions.
This patent grant is currently assigned to Societe d'Emballage et de Conditionnement. Invention is credited to Jean Chibret, Charles Manni.
United States Patent |
3,917,063 |
Chibret , et al. |
November 4, 1975 |
Packages enabling the extemporaneous preparation of suspensions or
sterile solutions
Abstract
A package for the extemporaneous preparation of suspensions or
sterile solutions, comprises two flasks at least one of which is of
a flexible material and which are adapted respectively to contain
one a liquid and the other a solid product to be dissolved in or
put into suspension in the liquid at the time of use. Each flask
has associated therewith stopper means and the package includes
means for temporarily putting the flask interiors into
communication with one another through at least one part of said
stopper means. Said at least one of the flasks is manually
deformable to effect the passage of the liquid from its flask into
the flask containing the solid product, and the return into said at
least one of said flasks of the resultant solution or
suspension.
Inventors: |
Chibret; Jean (Fontvieilie,
MC), Manni; Charles (Fontvieilie, MC) |
Assignee: |
Societe d'Emballage et de
Conditionnement (Fontvieille, MC)
|
Family
ID: |
9100094 |
Appl.
No.: |
05/367,437 |
Filed: |
June 6, 1973 |
Foreign Application Priority Data
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|
|
|
|
Jun 13, 1972 [FR] |
|
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72.21179 |
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Current U.S.
Class: |
206/221; 222/83;
141/329; 215/DIG.8; 366/129 |
Current CPC
Class: |
B65D
55/02 (20130101); B65D 81/3211 (20130101); A61J
1/2089 (20130101); A61J 1/201 (20150501); A61J
1/1406 (20130101); Y10S 215/08 (20130101) |
Current International
Class: |
A61J
1/00 (20060101); B65D 81/32 (20060101); B65D
55/02 (20060101); B65D 025/08 () |
Field of
Search: |
;206/219,222,221
;215/6,DIG.8 ;259/48,60 ;222/80,81,83 ;141/329,330,348,349 |
References Cited
[Referenced By]
U.S. Patent Documents
Foreign Patent Documents
Primary Examiner: Price; William I.
Assistant Examiner: Bernstein; Bruce H.
Attorney, Agent or Firm: McDougall, Hersh & Scott
Claims
We claim:
1. A package comprising two flasks of which at least one is of a
flexible material and which are adapted to contain one a liquid and
the other a solid product which is a selected member of the group
consisting of substances dissolvable in and substances suspendible
in said liquid at the time of use, stopper means on each flask and
means for temporarily putting the interiors of the two flasks into
communication with one another through at least one part of said
stopper means, said at least one of the flasks being manually
deformable to effect the passage of the liquid from its flask into
that of the solid product and the return of the solution or of the
suspension to the flask for the liquid, said flasks are kept
together in alignment and in readiness for the putting of their
contents into communication with each other by spacing means which
can be torn away.
2. A package as set forth in claim 1, in which the stopper means on
one of the flasks makes up at least partially a device for
perforating the stopper means on the other flask.
3. A package as set forth in claim 2, in which said one of the
flasks carries a dropper having a projecting end adapted for
perforations of the stopper means of the other of the flasks.
4. A package as set forth in claim 3, in which the stopper means of
said other of the flasks comprises a plug of elastomeric material
held in the neck of the flask and having an axial bore stopped by
means which can be overcome by said dropper projecting end.
5. A package as set forth in claim 4, in which said means which can
be overcome is an ejectable ball.
6. A package as set forth in claim 4, in which said means which can
be overcome is a perforable membrane.
7. A package as set forth in claim 4, in which said means which can
be overcome consists of an ejectable ball and a perforable
membrane.
8. A package as set forth in claim 7, in which the plug has
thereabove a washer which is impervious to the liquid and is formed
by a polyethylene disk coated on one of its faces with a film of
aluminium.
9. A package as set forth in claim 4, in which said plug has
thereabove a cover which includes a hemispherical central part
located in alignment with said axial bore and which can be cut off
at the time of use, said cover being retained on the plug by an
encasing ring on the rim of the neck of the flask.
10. The package of claim 3 further including removable means for
preventing the projecting end of said dropper from perforating the
stopper of the other flask.
11. A package as set forth in claim 1, wherein one flask is adapted
to be displaced relative to the other for putting the interiors of
the two flasks into communication with one another, such
displacement being under the guidance of an internally-threaded
tubular casing carried by one of the flasks and into which is
screwed a threaded neck of the other flask.
12. A package as set forth in claim 1 in which the flask containing
the liquid carries a removable cover adapted to be detached from
said spacing means and to replace the stopper means on the first
flask once opened.
Description
This invention relates to packages enabling the extemporaneous
preparation of suspensions or sterile solutions.
It is already known, especially for enabling the preparation at the
instant of use, of ophthalmic drops, to confine the lyophilic
material and the liquid to be mixed, separately, the first in a
flask and the second in an ampoule, the preparation consisting of
opening the flask, decanting therein the contents of the ampoule,
and mixing the whole, after having recorked the flask with a
dropper subsequently serving for delivery of the drops.
It is manifest that such a procedure does not permit proper regard
to be had for desirable aseptic conditions. Moreover, the operator
is compelled to carry out a large number of operations of which
each may involve a mistake or a difficulty.
The same holds true in the preparation of certain antibiotics for
which it is first necessary to inject a liquid into a flask by
means of a syringe, then to agitate the flask and to withdraw
therefrom the solution or suspension by means of the syringe before
injecting the patient, generally after having changed the
needle.
The primary object of the invention is to simplify these
preparations while paying proper regard to the usual conditions of
asepsis.
The present invention is a package comprising two flasks of which
at least one is of a flexible material and which are adapted to
contain one a liquid and the other a solid product to be dissolved
in or put into suspension in said liquid at the time of use,
stopper means on each flask and means for temporarily putting the
interiors of the two flasks into communication with one another
through at least one part of said stopper means, and in which the
passage of the liquid from its flask to that of the solid product
and the return of the solution or of the suspension to the flask
for the liquid may be effected by manual deformation of at least
one of the flasks.
This package enables there to be obtained a preparation the
sterility of which is perfectly maintained both in use and in
keeping in stock.
In a preferred form of the invention, the stopper means on one of
the flasks makes up at least partially a device for perforating the
stopper means on the other flask.
The invention will be better understood on reading the following
description in conjunction with the accompanying drawings which
illustrate, by way of example, embodiments of the invention, and in
which:
FIG. 1 is a sectional elevation of a package according to a first
embodiment of the invention, in the condition before the two flasks
have been put into communication with one another;
FIG. 2 is an "exploded" sectional elevation of the package shown in
FIG. 1;
FIG. 3 is a sectional elevation of a package according to a second
embodiment of the invention in the condition before the two flasks
have been put into communication with one another;
FIG. 4 is a sectional elevation of a package according to a third
embodiment of the invention in the condition after the two flasks
have been put into communication with one another;
FIG. 5 is an "exploded" sectional elevation of the package shown in
FIG. 4, the stopper means and the cover being in the condition
before the two flasks have been put into communication with one
another; and
FIG. 6 is a sectional elevation of a modified plug for the package
shown in FIGS. 4 and 5.
The package of FIGS. 1 and 2 is made up mainly by two flasks 1 and
2, the flask 1 containing a liquid and the flask 2 containing a
solid product. The flask 1 at least is of a flexible material.
The flask 2 is stopped by a plug 3 of elastomeric material provided
with a blind hole 4 located below a membrane 5. A ball 6 is held
captive resiliently in the plug 3.
Above the plug is a washer 7 which is impervious to the liquid in
the flask 1 and is formed by a polyethylene disk coated on one of
its faces with a film of aluminium.
The washer 7 itself has thereabove an internally-threaded tubular
casing 8, held in place on the plug 3 with the said washer by a
collar 9 flanged around and taking support on the rim of the neck
of the bottle 2.
The flask 1 is stopped by a dropper 10 the position of which in the
neck of the bottle 1 is limited by a shoulder 11. The flask 1 is
screwed by a thread 12 around its neck into the internally-threaded
tubular casing 8.
In its position prior to use, the end of the dropper 10, which is
open, rests on the impervious washer 7 and the relative position of
the flask 1 - dropper 10 assembly with respect to the flask 2 and
to the parts which are united therewith is ensured by a tearable or
rupturable spacing ring 13 accommodated in a peripheral space
between a peripheral external flange 20 around the neck of the
flask 1, and the adjacent end of the tubular casing 8. As shown in
FIGS. 1 and 2, the spacing ring 13 supports a removable cover 14
which can subsequently be used for covering and protecting the
lesser diameter end of the dropper 10.
The package of FIGS. 1 and 2 is used as follows:
the spacer ring 13 is torn and removed,
the flask 1 is screwed into the tubular casing 8, this occasioning
successively puncturings of the washer 7 and of the membrane 5 by
the end of the dropper 10 and the dropping into the flask 2 of the
ball 6 expelled from its seat,
deformation of the flask 1 brings about the passage of its contents
into the flask 2,
by agitation of the package, the solution or the desired suspension
is obtained. The ball 6 then plays the part of an agitator in the
flask 2 and speeds up the obtaining of the preparation,
the package is then inverted and the preparation sucked into the
flask 1, which is thereafter separated (with its dropper 10) from
the flask 2.
After the first use of the preparation, the dropper 10 is covered
by the cover 14 detached from the spacer ring 13.
For the description of the embodiments of the invention shown
firstly in FIGS. 3 and 4, and secondly in FIG. 5, parts similar to
those already described with reference to FIGS. 1 and 2 are
designated by the same references but provided with the indices a
and b, respectively.
The package of FIG. 3 includes two flasks 1a and 2a whereof the
former holds a perforating dropper 10a and the latter a plug 3a
with a ball 6a, an impervious washer 7a and an encasing ring 9a.
The initial positioning of the flasks 1a and 2a is ensured by a
spacing ring 15 which it is necessary to tear in order to enable
successively the perforation of the washer 7a and that of the
membrane 5a as well as the dropping of the ball 6a into the
receptacle 2a and the steps of transferring the products, such as
have been described with reference to FIGS. 1 and 2.
The package of FIGS. 4 and 5 is made up mainly of two flasks 1b and
2b whereof the former carries a dropper 10b closed at its end by a
bulging 16 which can be cut off. The flask 2b is stopped by a plug
3b with a perferable membrane 5b and a cover 17 kept on the flask
2b by an encasing ring 9b. The cover 17 includes a hemispherical
central part 18 which can be cut off just as can the bulged part 16
of the dropper.
In this package the flasks 1b and 2b are initially separated. At
the time of use, the bulged part 16 of the dropper 10b and the
hemispherical central part 18 of the cover 17 are cut off along the
respective dot-dash lines x and y indicated in FIG. 5. The
extremity of the dropper 10b is then introduced into the remaining
part of the cover 17, which ensures guidance of the dropper, and
the latter pierces the perforable membrane 5b of the plug 3b. The
package then being in the condition shown in FIG. 4, it is possible
to proceed with the transfer of the liquid and then the preparation
by deformation of the flexible flask or flasks.
In a modification of the package of FIGS. 4 and 5, there may be
used, instead of the plug 3b, the plug 3bb shown in FIG. 6 and
which includes a ball 6bb but no perforable membrane.
It will be manifest that the invention is not restricted to the
embodiments shown and described, but is capable of numerous
modifications within the purview of the expert in accordance with
any particular applications under consideration, without thereby
departing from the scope of the invention defined in the
claims.
* * * * *