U.S. patent number 3,791,767 [Application Number 05/234,935] was granted by the patent office on 1974-02-12 for dialysis pumping system.
Invention is credited to Karl Shill.
United States Patent |
3,791,767 |
Shill |
February 12, 1974 |
DIALYSIS PUMPING SYSTEM
Abstract
This invention relates to a dialysis pump and pumping system
primarily designed for the pumping of blood for purification in an
"artificial kidney machine" using the recently announced system of
the use of a single needle temporarily inserted into a vein or
artery of a patient through which blood is withdrawn from the vein
for purification and returned to the patient through the same
needle. Such a dialysis system requires a device, commonly called
an "occluder," by means of which blood from the filter is prevented
from entering the needle during the suction stroke of the pump of
the machine and is open to flow during the pumping stroke which, in
the preferred form, exerts a greater pressure than that supplied by
the body during the suction stroke of the pump.
Inventors: |
Shill; Karl (Fremont, CA) |
Family
ID: |
22883394 |
Appl.
No.: |
05/234,935 |
Filed: |
March 15, 1972 |
Current U.S.
Class: |
417/389;
128/DIG.3; 604/153; 604/6.05; 251/9; 417/394 |
Current CPC
Class: |
A61M
1/302 (20140204); A61M 1/30 (20130101); A61M
60/40 (20210101); F04B 53/1035 (20130101); F04B
43/10 (20130101); A61M 1/307 (20140204); F04B
43/08 (20130101); A61M 60/562 (20210101); A61M
60/113 (20210101); A61M 60/50 (20210101); A61M
60/268 (20210101); A61M 60/892 (20210101); A61M
60/894 (20210101); Y10S 128/03 (20130101) |
Current International
Class: |
A61M
1/10 (20060101); A61M 1/30 (20060101); F04B
43/08 (20060101); F04B 53/10 (20060101); F04B
43/10 (20060101); F04B 43/00 (20060101); F04b
009/10 () |
Field of
Search: |
;128/DIG.3 ;210/321
;417/383,389,394 ;251/9 |
References Cited
[Referenced By]
U.S. Patent Documents
Foreign Patent Documents
Primary Examiner: Freeh; William L.
Assistant Examiner: Sher; Richard
Claims
I claim:
1. A dialysis pumping system for use in connection with a single
needle dialysis technique in a machine in which blood is taken from
a patient and returned to the patient after treatment through a
single needle, said pumping system comprising:
a. a power section including
1. a chamber adapted to receive a liquid,
2.
2. a flexible bellows for communicating with said chamber,
3. a solenoid for operating said bellows, and
4. an outlet from said chamber;
b. a pumping section comprising
1. a cylinder, the intermediate portion of which has a larger
diameter than its ends,
2. a cylindrical flexible diaphragm within said cylinder, adapted
to receive a flexible tube carrying blood, said tube being provided
with one-way check valves, and
3. means for sealing the ends of said cylindrical diaphragm to the
ends of said cylinder and thereby providing a space between the
cylinder and the cylindrical diaphragm, and
4. passageways into the space lying between said cylinder and said
flexible diaphragm, said passageways communicating with the outlet
from the power section chamber;
c. an occluder comprising
1. a solenoid,
2. a rotary member rocked by said solenoid,
3. a slot in said rotary member adapted to receive a flexible tube
leading from a dialysis device,
4. a fixed post adjacent one end of said slot in said rotary
member; and
d. a power section for sequentially supplying discrete pulses to
said power
section solenoid and to said occluder solenoid. 2. The pumping
system of claim 1 wherein the solenoid in the power section and the
solenoid in the occluder are operated simultaneously.
3. The pumping system of claim 1 wherein the solenoid in the power
section and the solenoid in the occluder are operated
alternately.
4. The pumping system of claim 1 wherein the one-way valve in the
flexible tube carrying blood comprises:
a. a short stiff cylinder adapted to fit inside of said tube, said
cylinder having an annular indentation adapted to receive a
flexible ring,
b. a flexible ring embracing said blood tube and seated tightly in
the indentation in said cylinder,
c. a conical valve member formed of soft material enclosing a metal
plate of a diameter greater than the inside diameter of the
indentation in said cylinder and a metal stem depending from said
plate, and
d. means affixed to said stem adapted to prevent said stem from
passing through said indentation in said cylinder.
Description
BACKGROUND OF THE INVENTION
One of the surgical miracles of the last generation has been the
invention and development of the "artificial kidney machine",
referred to in medical circles as a "dialysis machine", by Dr.
Willem Kolff, now associated with the University of Utah. The
dialysis machine was first invented about 25 years ago and much
time and effort has been spent in trying to improve its operation,
to make it more efficient and to make it truly portable and less
expensive. One of the defects of prior machines has been the fact
that they were very large, very expensive and required treatment
under clinical or surgical conditions. Thus, most patients were
financially unable to get treatment because such machines could be
supplied only by large hospitals or well endowed clinics, and
treatment had to be secured every second or third day by spending
about 6 hours in the clinic. The research team directed by Dr.
Kolff at the University of Utah has very recently announced a truly
inexpensive dialysis machine which would be within the price range
of most American families and, which is more important, could be
utilized in the home. In the past, for dialysis treatment, a
patient had to undergo a surgical procedure by means of which an
artificial "plug-in" connection, or canula, was placed in an artery
and in a vein of a patient, blood being withdrawn from the artery
for treatment in the machine and then returned to the vein. Since
there are relatively few spots in the body where an artery is close
to the skin, the number of places where such a canula could be
placed in an artery was very limited. The life of such a canula is
quite short, as the natural bodily processes make it unusable, and
a new costly and painful surgical procedure was required. With the
new invention of a single surgical needle technique the canula
problems are eliminated. In this new procedure, a single needle is
inserted into a vein (many of which are close to the skin and,
therfore, readily accessible for withdrawing blood samples, taking
blood for transfusion or storage in a blood bank, etc.), and after
being purified, the blood is injected back into the patient through
the same needle. Such a system requires that a very small amount of
blood be withdrawn through any suction stroke in order to avoid
collapsing the vein, usually within the range of 1.5 to 2.5 cc. per
stroke at a rate of between 60 to 120 cycles per minute, depending
upon the age and size of the patient. During the suction stroke of
the dialysis machine, the blood is taken from the body of the
patient through the single needle and one leg of a Y connection;
and then, during the pumping stroke, passed through the filter and
back into the patient's body through the other leg of the Y
connection into the same needle. Such a system requires the use of
at least one valve device, or occluder, and which is operative to
shut off the flow of purified blood to the patient during the
suction stroke of the pump. Furthermore, this "occluder," as it is
commonly called, must operate in timed sequence to the operation of
a pump. Obviously, the occluder must be open for the passage of
blood during the time that the pump is pushing blood through the
filter and back into the body of the patient, but should completely
close the purified blood delivery line during that portion of a
cycle in which the pump is withdrawing blood from the body of a
patient.
One of the features of the present invention is that the volume of
blood pumped in each stroke is variable through a wide range and
adjustments can be made easily and accurately while the pump is in
operation. Another advantage is that the force applied to the blood
in the conduit is also variable over a considerable range, and
again adjustments can be made while the pump is in operation. More
important is the fact that the pump and occluder of the present
invention are isolated from the tubes carrying blood from the
dialysis filter and returning it to the body, so that neither the
pump nor the occluder need to be sterilized between uses. It will
be understood that in such a procedure as dialysis, the needle, the
blood tubes, and the filter, will have to be sterilized or replaced
between each use, and this is commonly done, but it is unnecessary
to sterilize either the pump or the occluder of the present
invention, as the sterilized tubes are placed within the pump and
occluder but do not communicate with them.
OBJECTS
It is a primary object of the present invention to provide a small,
light weight pumping system for a dialysis machine.
It is a further object of the present invention to provide an
artificial kidney pump with an infinitely variable volumetric
adjustment.
It is another object of the present invention to provide a pumping
system for a dialysis machine utilizing a single needle for the
withdrawal of blood from, and its return to, the patient.
It is still a further object of the present invention to provide a
quiet and positive occluder which controls the flow of the
patient's blood from, and the delivery of the purified blood back
to the patient, through a single hypodermic needle.
It is still a further object of the present invention to provide a
surgical pump and an occluder which, in themselves, do not have to
be sterilized, since only the tubes through which the blood passes
and the filter needs to be sterile since the tube, or tubes, may be
readily inserted through the two mentioned devices.
These and other objects of the present invention will be apparent
from the specification which follows, taken in conjunction with the
accompanying drawings in which:
FIG. 1 is a diagrammatic view of the pumping system of the present
invention.
FIG. 2 is a circuit diagram which controls the sequential operation
of the pump and occluder of the present invention.
FIG. 3 is a cross-sectional view of the power section of the pump
of the present invention.
FIG. 4 is a cross-sectional view of the pumping section of the pump
of the present invention.
FIG. 5 is a cross-sectional view in enlarged detail of the one-way
valve in the blood tube used in the pump shown in FIG. 4.
FIG. 6 is a view of one side of the occluder of the present
invention.
FIG. 7 is a view of the other side of the occluder shown in FIG. 6;
and
FIG. 8 is a plan view of the occluder of the present invention.
SPECIFICATION
The pumping system of the present invention comprises four major
sections: (A) a power unit 30; (B) a pump section 50, which may be
constructed integrally with the power unit 30, or which may be
separated therefrom as shown in FIGS. 2 and 3; (C) an occluder 110;
and (D) a power control unit 140. For ease in understanding, these
four sections will be discussed separately, but for purposes of
construction, the power unit 30, the pump section 50 and the power
control unit 140 can be built as an integral unit, and presumably
would be; however, the occluder 110 normally is preferably placed
as close to the patient as possible, and therefore can be somewhat
removed from the other three.
A. Power Unit
Construction of the pump section 30 is shown in detail in FIG. 3.
Basically, it comprises a solenoid 31 contained within a casing 32
which may be made of plastic, or any other suitable material. The
plunger 33 of the solenoid is spring-biased to an extended position
by means of a relatively strong spring 40 and bears against a
collapsible bellows 34. The interior of the bellows 34 communicates
with a pressure chamber 35 which, by means of a tube 36, is in
fluid communication with the pumping section 50. This connecting
tube 36 may be valved as at 37 as shown. The chamber 35 also
communicates with a filling tube 38 which must be closed as by
means of valve 39. Power is supplied to the solenoid 31 in timed
pulses through power line 41 leading from the power supply assembly
140 shown in FIG. 2. When electrical power is supplied to the
solenoid 31, the plunger 33 is retracted, pulling the bellows 34
(to the left in FIG. 3) to its extended position, thereby sucking
the fluid from the chamber 35, tube 36 and the intermediate chamber
75 in the pumping section 50. Then, when the circuit to the
solenoid 31 is de-energized, the force of spring 40 forces the
plunger 33 and the bellows 34 to the right, thereby expelling fluid
from the bellows 34 into chamber 35 and thence by tube 36 into the
interior chamber 75 of the pumping unit 50.
B. Pump Unit
The pump unit 50 is almost identical with that shown in my
copending application, Ser. No. 191,207, now U.S. Pat. No.
3,724,973 but differs therefrom sufficiently that a complete
description is deemed to be in order. Normally, it would be about
half the size of a pump designed for heart surgery, as was the case
in that application. It comprises a casing 51 that has a relatively
tight fit with the bore 52 of a casing support block 53 which, in
turn, is rigidly secured to a mounting plate 54 by any suitable
means, such as machine bolts 55. The casing 51 can be locked in
position by a set screw 56 threaded into the block 53 and
registering with an annular groove 57 formed in the outer wall of
the casing 51. The annular groove 57 in the casing permits rotation
of the pump casing 180 if desired, but not longitudinal movement in
its support.
The casing 51 is also provided with an annular groove 60 which
registers with a supply port 61 to which the liquid supply tube 36
is affixed, when the pump is in the proper position. A plurality of
radial orifices 62 lead from the annular groove 60 into the
interior portion of the cylindrical casing 51. Preferably, a pair
of O-rings 63 and 64 are contained within annular grooves 65 and 66
formed in the outer wall of the casing 51, one on each side of the
supply port 61. This construction provides a water-tight seal
between the casing 51 and its retaining block 53 on either side of
the supply port so that no liquid will be lost during
operation.
I prefer to seal the interior of the casing 51 by a flexible
tubular membrane 70. Preferably, this membrane will be a silastic
tube which will be passed lengthwise through the casing 51 as shown
in FIG. 4. The two ends of the cylindrical membrane 70 are
preferably sealed as by means of folding over a conical collar 71,
placing a truncated conical thimble 72 thereover, and rigidly
sealing the assembly by means of a cap 73 which is threaded onto
suitable threads formed on the ends of the casing 51. A gasket
member 74 compressed between the conical collar 71 at the end of
the casing seals the tubular membrane 70 against leakage.
Preferably, as shown in FIG. 4, the interior of the casing 51 is
enlarged except at its very ends, thereby providing an elongated
cylindrical chamber 75 throughout most of the length of the casing
and lying between the wall of the casing 51 and the tubular
membrane 70. Thus, throughout most of its length within the casing
51, the silastic tube 70 will not lie against the wall of the
casing but will be embraced by the liquid which communicates with
the pumping section 30. This liquid will completely encompass the
tube 70 throughout most of its length within the casing at all
times. This construction permits the rapid and equalized
transmission of pressure to the entire length of the pump chamber
on the pump stroke; and also the rapid and equalized vacuum thereto
on the suction stroke. It also provides an additional safeguard
against the intermingling of liquid from the pump itself to the
blood being pumped. The blood to be pumped passes through a short
section of silastic tubing 80 of a length slightly greater than the
length of the casing 51. Preferably, this tube 80 is provided at
each end with a pair of conical nipples 81 and 82 over which the
blood supply tube 22 and the pump delivery tube 28 can be forced.
It is obvious, of course, that the blood supply tube 22, the pump
section 80 and delivery tube 28 can be fabricated as a single tube
and then the nipples 81 and 82 would be unnecessary. The tube 80 is
provided with a pair of one-way valves 83 which can be of any
suitable construction, but preferably is of the style shown in
detail in FIG. 5. Preferably, the tube 80, its nipples 81 and 82
and the pair of one-way valves 83 will be pre-sterilized and
contained within a sterilized casing 84 which can be suitably
sealed at the time of sterilization. When the device is to be used,
the casing 84 serves to pull the assembly through the pump chamber
51 contained within the membrane 70 in the casing 51. The ends of
the casing 84 can then be snipped so that the suction tube 22 can
be forced over the nipple 81 and the discharge tube 28 forced over
the nipple 82, and the pump is ready for operation.
I have found that the one-way valve of the type shown in FIG. 5 is
better for use in a dialysis machine. Each valve comprises a stiff
cylindrical collar 90 having an annular indentation 92
(semi-circular in shape in cross-section) formed adjacent the upper
edge thereof. The collar is inserted (and may be cemented) within
the tube 80 at the locations to lie within the tube 80 immediately
adjacent the conical collars 71. Obviously, both valves are pointed
in the same direction so that the valve at the inlet end will
permit the entry of blood into the pumping chamber but not
backwardly therefrom, while the valve in the outlet end permits the
blood to be expelled from the chamber but not to return thereto. As
mentioned, the collar 90 is formed with an annular groove 92,
adapted to receive an O-ring 91 which is inserted over the blood
tube 80 and lies within the semi-circular groove 92 formed in the
stiff collar 90. This locks each one-way valve in the proper
position. The semi-circular groove 92 also forms an excellent valve
seat for the valve member 93 which preferably is formed of a soft
silastic material. The silastic material is molded around a frame
comprising a plate 94 of greater diameter than the valve seat 92
and a valve stem member 95 rigidly secured thereto. Both parts of
the frame preferably are formed of metal to add weight to the valve
member 93 so that gravity will readily seat it on its cooperating
valve seat 92 as soon as pressure to lift the valve member 93 off
the seat ceases. The metal frame also prevents an exceedingly
strong backward force from forcing the valve member 93 through the
seat 92, which readily can be done to a silastic valve member which
does not have such metal reenforcemnt. Preferably, the silastic
material forming the valve member 83 is of the soft type so that it
will seat tightly against the indentation in the collar, regardless
of any deformation in the collar 90. The valve member 93 is also
locked against excessive upward movement by any suitable means,
such as a locking member 96, which preferably can be a C-clamp
whose interior diameter is smaller than the valve stem so that it
can be forced over the soft silastic material which forms the valve
stem. Thus, the valve member 93 is held in position between the
limits imposed by collar 90.
C. Occluder
The occluder 110 is shown particularly in FIGS. 6, 7 and 8. It
comprises a mounting plate 111 provided with a suitable aperture
112 so that the occluder can be hung close to the patient, or in
any other suitable position. A solenoid 113 is secured to the
mounting plate by any suitable means, not shown, and is supplied
with electric power by a power lead 114. The solenoid armature 115
is pinned to a link 116 which, in turn, is pinned to a gear 117
that is rotatably mounted on a pin 118 secured in the mounting
plate 111. A tension spring 119 pulls the gear 117 (clockwise in
FIG. 6) to pull the link 116 in armature 115 to the extended
position shown in this figure. The gear 117 meshes with a smaller
gear 120 that is pinned on, or otherwise rigidly secured to, a
shaft 121 journalled in the mounting plate 111. The gear 120 is
preferably smaller than the gear 117 in order to rock this gear
through a larger arc than would be secured from the direct movement
of the armature 115 itself. On the other end of the shaft 121, as
shown in FIGS. 7 and 8, is an occluder collar 125 which is rigidly
pinned on, or otherwise secured to, the shaft 121. The outer end of
the collar 125 is provided with a slot 126 adapted to receive and
retain the blood delivery tube 23. It is preferred that the collar
125 be so mounted on its shaft that the slot 126 lies in a vertical
position when the occluder is to permit flow of blood from the
dialysis filter 26 to the patient, as is shown in FIGS. 7 and 8.
This permits the flow of blood with a minimum of friction or other
restrictive forces. Also, the memory of the tube itself tends to
straighten it when the occluder is at rest.
When the solenoid 113 is operated and the collar 125 rocked thereby
(counter-clockwise in FIG. 7), the tube 23 is rocked against a post
127 which is mounted on the backside of the plate 111 immediately
adjacent the collar 125. This rocking of the tube 23 against the
post 127 pinches the tube against post 127, as shown in dotted
lines 23a in FIG. 7, and thereby closes the tube to the passage of
blood therethrough. As soon as the pulse which operates the
solenoid ends, however, the spring 119 and the elastic memory of
the tube itself immediately returns the tube and occluder to the
vertical position shown in these figures.
The occluder can also be operated as a "fail safe" device to shut
off vital flow of blood in emergencies, as when the patient is
asleep, by using the power stroke of the solenoid to open occluding
action and have the spring force of spring 119 strong enough to
occlude the tube 23. Thus, the occluder mechanism may replace the
spring set blood clamp now used.
D. Power Supply
The power supply 140 can be mounted on any suitable member, such as
a plate 141 shown in dotted lines in FIG. 2 and supplied from any
suitable electrical supply, such as leads L-1 and L-2. The power
supply for such devices are well-known and the present invention
utilizes components that can readily be secured on the market.
Hence, it is not deemed necessary to explain them in detail. It
should be sufficient to note that the power supply 140 contains a
converter, or transformer, 142 to convert normal A.C. current to a
direct current of reduced voltage of, say, 12 volts. It also
contains a pulsation, or timing circuit 143 and a power amplifier
144. The pulsation timing circuit is adapted to supply a power
pulse to the lead 41 which operates the pump actuator 30 and lead
114 which actuates the occluder 110, and then break the circuits
thereto. In the embodiment shown, the two pulses are simultaneous.
However, it is important to note that in another form of the
present invention, the timing circuit operates to supply power to
the pump actuator 30 and the occluder 110 alternately, so that
while power is being supplied to the solenoid 31 of the pump
actuator 30, none is being supplied to the solenoid 113 of the
occluder 110, and vice versa. Thus, the two solenoids 113 and 31
operate alternately, which causes a minimum requirement of power as
only one of the solenoids can be operative at one time.
The heperin (anti-coagulant) pump 24 can be operated independently
of the pump actuator 30 connecting its power supply line 145 to a
suitable source of power. Since only 1.5 milliliters of heparin are
needed per hour, this pump 24 will normally be operated
independently.
It should be noted that the speed (number of cycles per minute),
the length of the pulse, and the relative length of the pulses with
respect to the periods of rest can be adjusted by the usual
conventional means, such as adjusting member 146. Normally, the
pump (and the occluder) will be operated at speeds ranging from 60
to 120 cycles per minute. The test embodiment of the present
invention has been operated at speeds of from 50 to 150 cycles per
minute by adjusting the timer 143.
OPERATION
(Using the single needle technique developed at the University of
Utah Biomedical Laboratory)
The operation of the present device will be readily understood by
reference to FIG. 1. The usual surgical hypodermic needle 30 can be
inserted into any suitable vein of the patient. A Y member 21 is
affixed to the needle 20 and a suction tube 22 and a delivery tube
23 are connected to the Y member 21. The suction tube 22 leads to
the inlet nipple 81 of the pump 50, while an outlet tube 28 is
connected to the outlet nipple 82 of the pump. The duct 28 leads to
a plurality of ducts, such as 28a and 28b of the conventional
dialysis filter. After being filtered, blood is collected in branch
delivery tubes 23a and 23b and then passes into a bubble trap 27
and thence into the delivery tube 23. Since the filter 26 and the
bubble trap 27 are of known construction, it is believed
unnecessary to refer further to them. It can also be noted that it
is conventional practice to inject a very minute amount (usually in
the order of 1.5 milliliters per hour) of heparin into the suction
tube 23 as by means of a heparin pump 24 which leads to a suitable
T connection 25 in the suction tube 22. This pump can be operated
by an independent power supply through lead 145. The delivery tube
23 is passed through the slot 126 of the occluder collar 125. When
the power supply assembly is connected to a suitable source of
power, such as conventional house current of 110 volts, it provides
pulses to the pump actuator 30 and the occluder 110. When power is
supplied to the solenoid 31 of the pump actuator 30, the plunger 33
of the solenoid is pulled (to the left in FIG. 3), thereby sucking
liquid from chamber 35, tube 36 and the inner chamber 75 lying
between the wall of the casing 51 and the inner membrane 70, which
action applies suction to the tube 22 and hence draws blood through
the needle 20 and Y 21. On the alternate operation, when power is
shut off from the solenoid 31, the spring 40 of the pump actuator
forces the diaphragm armature and its associated bellows 34 (to the
right in FIG. 3), and hence forces liquid back through chamber 35,
tube 36 and into chamber 75 of the pump. This, in turn, forces
blood from the inner tube 80 up through the outlet one-way valve 83
and thence into discharge tube 28 leading to the dialysis filter
26. Simultaneously with the sequential operation of the solenoid 31
of the pump actuator 30, the solenoid 113 of the occluder 110 is
supplied with sequential pulses of power in step with those
supplied to solenoid 31 of the pump actuator. When supplied with
power, the occluder solenoid 113 rocks the collar 125 to pinch the
tube 23 against post 127, and thereby terminate the flow of blood
from the filter 26 into the patient. With the termination of power
to solenoid 113, spring 119 rocks gears 117 and 120 to the position
shown in FIG. 6, thereby rocking collar 125 to straighten delivery
tube 23 and permit blood to flow to needle 20. Thus, the pump
actuator 30 and the occluder 110 are operated in a timed sequence
to simultaneously operate the pump 50 in its suction stroke and
close occluder 110 to the flow of blood, and then operate the pump
in its pumping stroke and open the occluder to the flow of
blood.
The timing of the pump cycles can be varied according to
modification of the pulsation timing circuit by well-known means,
and that the amount of blood supplied at any stroke can be
accurately controlled by adjustment of the valve 37 in the pump
actuator duct 36. These changes can be made while the pump is in
operation or preset as desired.
It is believed that these and other advantages of the pump system
of the present invention will be obvious to those skilled in the
art. Accordingly, it is intended that all modifications which lie
within the scope of the underlying inventive concepts are to be
included within the scope of the claims and the invention is not to
be limited to the particular forms herein shown and described.
* * * * *