U.S. patent number 3,640,437 [Application Number 04/888,370] was granted by the patent office on 1972-02-08 for package for ampoules containing lyophilized products.
This patent grant is currently assigned to Societe Anonyme dite: Institut Merieux. Invention is credited to Michel Galy.
United States Patent |
3,640,437 |
Galy |
February 8, 1972 |
PACKAGE FOR AMPOULES CONTAINING LYOPHILIZED PRODUCTS
Abstract
A package for ampuls containing lyophilized products comprising
a box adaptable to contain a plurality of the ampuls and formed of
at least two assemblable elements, two of which each have an
internal orifice for engaging an end of the ampul over a certain
length thereof so as to allow breaking of the ampul by grasping one
element in each hand.
Inventors: |
Galy; Michel (Lyon,
FR) |
Assignee: |
Societe Anonyme dite: Institut
Merieux (Lyon, FR)
|
Family
ID: |
8659171 |
Appl.
No.: |
04/888,370 |
Filed: |
December 29, 1969 |
Current U.S.
Class: |
225/96.5;
206/446; 206/538; 225/103 |
Current CPC
Class: |
B65D
85/42 (20130101); A61J 1/065 (20130101); C03B
33/06 (20130101); B65B 3/006 (20130101); Y10T
225/371 (20150401); Y10T 225/325 (20150401) |
Current International
Class: |
A61J
1/06 (20060101); B65B 3/00 (20060101); B65D
85/42 (20060101); C03B 33/06 (20060101); C03B
33/00 (20060101); B26f 003/00 () |
Field of
Search: |
;225/93,103,96.5 ;81/3R
;206/65A,63.2A ;128/272 |
References Cited
[Referenced By]
U.S. Patent Documents
Primary Examiner: Yost; Frank T.
Claims
What is claimed is:
1. Package for an ampul intended particularly for plug-formed
lyophilized products, characterized in that it is constituted by a
cylindrical glass receptacle closed at its ends, the said
receptacle presenting, toward its middle part, a weakened zone
constituted by a groove made on the periphery of the ampul, said
package having the form of a box containing a plurality of ampuls
and formed of at least two assemblable elements, two of the said
elements each presenting an orifice inside of which it is possible
to engage an end of the ampul over a certain part of its length to
allow the breaking of an ampul by grasping one element in each
hand.
2. Package as in claim 1, characterized in that the two elements
which each present an orifice form, by their joining on the body of
the box, the cover of the said box, each of the two said orifices
being disposed inside the cover that is thus formed.
3. Package as in claim 1, characterized in that the two elements
are made of a relatively flexible material such as plastic or
wood.
4. Package as in claim 1 characterized in that the orifice of each
of the elements extends over only a part of the length of these
pieces.
5. Package as in claim 1 characterized in that the orifice of each
of these elements presents at least three ribs on which the ampul
bears while it is opened.
Description
The present invention relates to a new ampul intended primarily to
contain lyophilized products, which has the advantage of being
readily broken, and from which the plug of lyophilized product can
be extracted without difficulty.
The present invention likewise relates to an apparatus for the
manufacture of these new ampuls.
It happens in certain instances that the lyophilization is effected
starting from a relatively large volume of suspension in a liquid,
which means that this suspension is placed in an open ampul with a
relatively large diameter.
Since moreover it is not possible with known devices to proceed to
the breaking of a large diameter ampul part, it has been necessary
in this case to use ampuls which have a neck at the level of which
the break is made, either by a sawed line, or by prestressing of
the glass at the time of manufacture of the ampul.
Such ampuls presently in use do not give entire satisfaction
because the lyophilized product in the form of a plug of the same
diameter as the ampul cannot be extracted through the ampul neck,
which makes it necessary to dissolve it inside the ampul.
There is some inconvenience for the user as the result of this, and
the objective of the present invention is the development of ampuls
for lyophilized products that do not present the above-mentioned
drawback.
The present invention relates to a new industrial product which is
an ampul intended especially to contain lyophilized products,
characterized in that it comprises a cylindrical glass receptacle
closed at its ends, the said receptacle presenting, preferably in
its midportion, a weakened zone constituted for example by a groove
at its periphery, the said zone being preferably covered by a
pasted sheet.
The said ampul before filling is a cylindrical receptacle closed at
one end and open at the other, in which receptacle there is placed
the quantity of solution or suspension that is to be lyophilized.
Receptacles thus filled are suitably subjected to lyophilization in
a customary manner, to form within them a plug of the lyophilized
product constituted by a rather compact mass with a diameter
slightly less than the internal diameter of the receptacle and a
length that is a function of the quantity of the product. The open
end of the receptacle is then closed in a customary manner.
At this stage there is a cylindrical glass tube closed at both
ends, containing the plug of lyophilized product.
According to a preferred method of the invention, there is
developed, preferably near the middle of the receptacle, a weakened
zone obtained by hollowing a groove on the periphery of the tubular
body of the receptacle. This can be done by any means, especially
by use of a new apparatus that is to be described below.
In this condition, it is possible to store the receptacle
containing the lyophilized product, and the peripheral groove has
no deleterious effect on the preservation of the product.
To extract the plug of lyophilized product, it is sufficient to
take an end of the receptacle in each hand, placing the thumbs near
the groove and exerting force that tends to bend the receptacle to
cause a clean break of the latter at the level of the groove, the
plug of lyophilized product then slipping very readily from the
part of the receptacle where it is located.
In an improved modification of the invention, the tubular body of
the receptacle is surrounded at the level of the groove by a pasted
sheet that tears at the same time as the ampul and which is
intended, because of its adhesive part, to hold any small glass
splinters that might be produced when the glass is broken.
In a preferred embodiment of the invention the adhesive sheet
comprises a self-sticking label that effects the function mentioned
above while allowing ready identification of the product that is
contained in the ampul.
The present invention likewise relates to a new industrial product
that comprises a package that facilitates the opening of the
above-described ampuls, the said package being essentially
characterized in that it is constituted of two discrete pieces of
size sufficient to be grasped separately between the fingers of one
hand, and which each present an orifice inside of which it is
possible to engage an end of the ampul of the invention.
By virtue of this package, the separate parts of which are placed
on the ends of the ampul of the invention, the opening of the said
ampul is greatly facilitated because the parts in question allow an
amplification of the force exerted by the user.
In accordance with the invention, it is preferable to make the two
parts of the package in question of a relatively flexible material
such for example as plastic or wood, because the elasticity of the
device promotes a good break in the ampul of the invention.
In a preferred embodiment of the device described above, the two
parts or elements of the package constitute the cover of a box that
contains the ampuls of the invention. The user thus has at his
disposal a simple and practical means for storing and opening the
ampuls.
The present invention relates finally to a new industrial product
which comprises an apparatus for making a groove on the peripheral
part of a tubular body, particularly on the periphery of a
cylindrical glass ampul, characterized essentially in that it
comprises in combination means that allow the turning of the
tubular body on its own axis at a low rate of speed without moving
in the direction of its axis, and means whereby the periphery of a
rotating driven abrasive disk is brought into contact with the
tubular body, which remains in the same plane.
In a preferred embodiment of the invention, the abrasive disk is
mounted on an oscillating member on which there is likewise mounted
a lever with a roller, near the part of the abrasive disk that is
to work on the tubular body, the said lever being recalled by
elastic means that separate its roller from the axis of the said
abrasive device and cooperating with a stop that limits its
movement toward the axis of the abrasive disk when the oscillating
member is moved in the direction of the tubular body.
Other features and characteristics of the invention will appear in
the following description, with reference to embodiments shown in
the attached drawing in which:
FIG. 1 is a view of the ampuls of the invention stored according to
a special embodiment, in perspective;
FIG. 2 is a view in perspective showing how the ampul can be opened
by use of the two parts of the cover of the box shown in FIG.
1;
FIG. 3 is a view in section along III--III of the central part of
the ampul of FIG. 2;
FIG. 4 is a view in section of a half of the cover of the box along
line IV--IV of FIG. 1;
FIG. 5 is a view in perspective of an embodiment of the apparatus
which effects production of the peripheral groove on the
ampuls;
FIG. 6 is a view in section along VI--VI of FIG. 5, showing the
mounting of the diamond-coated bronze abrasive disk;
FIGS. 7, 8 and 9 show schematically the operation of the feed
device for the ampuls;
FIGS. 10, 11 and 12 show schematically the different stages of
production of the peripheral groove on an ampul, and
FIG. 13 is a view in section of the drive rollers along XIII--XIII
of FIG. 10.
In FIG. 1, there is shown in perspective a plurality of ampuls of
the invention (designated as a whole by reference numeral 1) stored
in a box 2 whose cover comprises two parts 3 and 4 which can be
fixed onto the body of box 2 by sliding along grooves 5 or by
perpendicular engagement with the said grooves by virtue of the
elasticity of body 2 and parts 3 and 4 of the cover which are made
of a semihard plastic material.
As shown in the drawing, parts 3 and 4 which are identical present
an orifice 6 at one of their ends, which orifice extends in the
present case over about half their length and which, in the
embodiment illustrated, presents three ribs 7 which delimit a space
that corresponds substantially to the dimensions of ampul 1.
In the illustrated embodiment, body 2 of the box presents in its
lower part partitions 8 which allow separation of the different
ampuls stored in the box. In the present case, the box is intended
to contain six ampuls, but it is obvious that the number can be
arbitrary.
As shown in the drawing, ampul 1 is constituted by a cylindrical
tubular body whose two ends 9 are closed in a known rounded form.
Ampul 1 contains a plug 10 of lyophilized product that can be of
any kind, e.g., live enzymes.
The drawing shows groove 11 on the periphery of ampul 1 near the
center thereof. Said groove 11 is constituted by a light cut made
to a certain depth of the ampul wall, to constitute a weakened
zone.
The drawing likewise shows how a self-adhering label 12 is placed
above groove 11 all around the ampul.
This label is preferably provided with a self-sticking substance.
When the ampul is broken along groove 11 it allows retention of any
glass splinters that might break off.
To open the ampul, parts 3 and 4 of the cover of box 2 that are
held in each hand are placed on the two ends of the ampul, and
using parts 3 and 4 a couple (represented in the FIG. 2 by arrows)
is exerted on the ampul, which results in a clean break at the
level of groove 11.
It is then only necessary to tilt the part of the ampul that
contains the plug of lyophilized product to cause it to fall out of
the ampul.
Of course, the ampul can be opened without use of the box cover,
simply by taking the ends of the ampul in either hand.
In the embodiment shown, pieces 3 and 4 present ribs 7 which
delimit orifices 6. These ribs offer the advantage of holding an
ampul with a certain elasticity, but it is clear that they are not
indispensable to the invention.
In FIGS. 6 to 13, an apparatus for making groove 11 on ampul 1 is
shown.
It is seen in FIG. 5 that the apparatus comprises two fixed racks
20 whose V notches are intended to receive the ampuls, which are
held in position because their ends are guided by fixed plates 21
on both sides of racks 20.
Between the two fixed racks 20 there is a movable rack 22 which
effects a step by step drive of the ampuls, moving them from one
notch to another.
Movable rack 22 is driven in a circular movement by an arrangement
whereby it is articulated at one end, at 23, to a pin 24 which
turns about a fixed pin 25. At the other end, the movable rack is
articulated at 26 to a plate 27 which is driven in rotation by a
motor 28, via a reducing gear 29.
Two rollers 30 and 31 are mounted on either side of the fixed racks
at the level of a single notch, and they are driven in rotation in
the same direction by a motor 32, by a system of belts and pulleys
that is schematically shown in FIG. 5.
At the upper part, an oscillating member 33 is pivoted at 34 on the
frame of the apparatus. The oscillating member supports an abrasive
disk 35 made of diamond coated bronze, mounted between two plates
36 as shown in FIG. 6. Abrasive disk 35 is driven in rotation by a
motor 37 by means of a system of belts and pulleys that is
schematically illustrated.
A swinging lever 38, pivoted also on 34, bears at one of its ends a
free wheel 39 so placed as to be directly above ampul 1 which is on
rollers 30 and 31.
A recall spring 40 (one of whose ends is rigidly connected to lever
38 while its other end is fixed on oscillating member 33)
constantly urges wheel 39 in the direction of ampul 1, until end 41
of lever 38 is applied against an adjustable stop screw 42. Another
adjustable stop screw 43 allows limitation of the movement of lever
38 in the other direction, with reference to the oscillating
member. Moreover, a recall spring 44 acts on oscillating member 33
to apply abrasive disk 35 against the tube.
A motor 45 which drives a disk 46 by means of a reducing gear 47
causes the oscillation of member 33 by means of a link 48 that is
joined by an elongated slot 49 to a stud 50 that is fixed to the
end of member 33.
The movement of link 48 and the size of its slot 49 are such that
at each turn of plate 46 the link acts during a certain interval to
lift the abrasive disk away from ampul 1, whereas during the rest
of the cycle link 48 has no effect on the action of the oscillating
member because of slot 49.
The speed of motor 32 is set in such a manner that rollers 30 and
31, each provided on its periphery with a rubberized ring 51, are
driven with a relatively low peripheral speed, which may be, e.g.,
25 meters per minute. During the operation of the apparatus, motor
32 continuously drives rollers 30 and 31.
Motors 28 and 47 function intermittently to effect the lifting of
abrasive disk 35 above ampul 1 and to synchronize the advance of
all tubes that are placed on the racks.
During operation, the motor 39 also permanently drives the abrasive
disk at a relatively high peripheral speed, e.g., a rate of 900
meters per minute.
In FIGS. 7 to 9 there is schematically shown the functioning of the
step by step advancing device for the ampuls.
In these figures there are again schematically shown a fixed rack
20 and a movable rack 22 which is driven in a movement of rotation
about shaft 25.
The successive notches of fixed rack 20 are designated A, B, C, D,
and the corresponding notches of rack 22 are designated A', B', C',
D'.
In FIG. 1, notches A, B, C, D of fixed rack 20 are opposite
corresponding notches A', B', C', D' of movable rack 22, while the
three ampuls I, II, III are placed respectively in notches B, B',
C, C', and D, D' of the racks.
When movable rack 22 is driven in a movement of rotation, it begins
to lift, moving toward the left, and after a quarter turn of plate
27, rack 22 has assumed the position shown in FIG. 8 in which
ampuls I, II and III are lifted and moved by a distance equal to
half the space that separates two notches.
It is to be noted that by turning plate 27 another quarter turn,
movable rack 22 moves to the level of fixed rack 20, with
correspondence of the notches, except that it is now notches B',
C', D' of the movable rack that correspond to notches A, B, C of
the fixed rack, each of the ampuls I, II, III having progressed by
one notch toward the left.
When plate 27 effects still another half turn, movable rack 22
moves downward, so that it has no effect on the ampuls.
Thus it is seen that the device effects a step-by-step advance of
the ampuls by causing them to pass from one notch to the next.
Now it will be explained how the groove of the invention is
made.
In FIGS. 10, 11, 12 there are shown abrasive disk 35, rollers 30
and 31 which support ampul 1, driving it in rotation, the end of
lever 38 with wheel 39, and adjustable stop 43.
To explain the operation of the apparatus, it is assumed that a new
ampul 1 has just been carried onto rollers 30 and 31 as explained
above, while link 48 acts on stud 50 to lift the abrasive disk
35.
From this moment, operation of the device is as follows.
The rotation of plate 46 gradually releases oscillating member 33
which, because of spring 44, swings about shaft 34 in the direction
of ampul 1.
Since spring 40 tends permanently to urge wheel 39 toward ampul 1,
it is the said wheel 39 that first comes into contact with the
ampul 1, being driven in rotation thereby.
However, since spring 44 has sufficient force, abrasive disk 35
continues to descend toward ampul 1, while wheel 39 remains applied
thereto and lever 38 pivots with reference to oscillating member
33. This stage corresponds to the stage shown in FIG. 10, the
abrasive disk not yet being in contact with the ampul.
Then the abrasive disk which continues to descend comes into
contact with ampul 1 and beings to hollow out groove 11, as shown
in FIG. 11.
This work continues until the stop 43 which is rigidly connected to
oscillating member 33 is applied against lever 38. In this position
which corresponds to that shown in FIG. 12, wheel 39 which bears on
ampul 1 prevents abrasive disk 35 from deepening groove 11. The
position of abrasive disk 35 thus remains as indicated in FIG. 12
until plate 46 causes a movement of the link which is sufficient
once more to lift the abrasive disk, which ends the cycle.
It is clear that it is possible readily to adjust the depth of
groove 11 by acting on movable stop 43.
It is understood that different embodiments of the invention which
have been described above are in no way limiting and that they can
be modified in any way that is desirable without exceeding the
scope of the invention.
Especially it is clear that the groove made on the periphery of the
middle part of the ampul can be made in a manner other than that
which has been described. Similarly, the zone of weakening, at the
level of which the breaking of the ampul is effected, can be made
by a means other than a groove without exceeding the scope of the
invention.
Finally, it is clear that although the invention has been described
with special reference to ampuls that are to receive lyophilized
plug-formed products, the invention applies also to ampuls that
contain any kind of products, solid, pulverous or liquid.
* * * * *