U.S. patent number 3,590,889 [Application Number 04/816,352] was granted by the patent office on 1971-07-06 for injector filling apparatus.
This patent grant is currently assigned to Hamilton Company. Invention is credited to Tom H. Vannus.
United States Patent |
3,590,889 |
Vannus |
July 6, 1971 |
INJECTOR FILLING APPARATUS
Abstract
Apparatus for filling at least the needles of injector devices
or syringes by pressure. A vial having a fluid sample therein has
means for putting the sample under substantial pressure for forcing
same into an injection device.
Inventors: |
Vannus; Tom H. (Pomona,
CA) |
Assignee: |
Hamilton Company (Whittier,
CA)
|
Family
ID: |
25220363 |
Appl.
No.: |
04/816,352 |
Filed: |
April 15, 1969 |
Current U.S.
Class: |
141/18; 422/643;
73/864.01; 141/329; 73/864.02; 141/357 |
Current CPC
Class: |
A61M
5/1782 (20130101); G01N 1/14 (20130101); A61J
1/201 (20150501); A61J 1/2096 (20130101) |
Current International
Class: |
A61M
5/178 (20060101); G01N 1/14 (20060101); A61J
1/00 (20060101); B01z 003/00 () |
Field of
Search: |
;23/253,259,292
;73/422GC,425,425.2,425.4,425.4P ;141/18,21,25--27,114,329,330,357
;222/82,326,386 |
References Cited
[Referenced By]
U.S. Patent Documents
Primary Examiner: Geiger; Laverne D.
Assistant Examiner: Earls; Edward J.
Claims
I claim:
1. Injector filling apparatus comprising:
A. a nondeformable container for a fluid sample, said container
being closed at one end and open at the other end;
B. a self-sealing septum positioned for sealing the open end of the
container and adaptable to have injector needle means insertable
therethrough;
C. and piston means in said container having a bore therethrough
adaptable to receive the injector needle means therein and whereby
downward movement thereof places a fluid sample in the container
under hydraulic pressure and charges the injector needle means with
at least a portion of the sample.
2. Injector filling apparatus, comprising:
A. a container for a fluid sample, said container being closed at
one end and open at the other;
B. pierceable seal covering the open end of the container;
C. pressurizing means for putting a fluid sample in the container
under pressure for charging an injector with at least a portion of
the sample, said pressurizing means comprising a container plunger
having a bore extending longitudinally therethrough;
D. a cap for retaining the seal sealingly on the open end of the
container, said cap having an outer end wall with an axial bore
therethrough flaring upwardly, the bore through the container
plunger being axially arranged so that the bore in the cap is in
axial alignment with the bore in said container plunger.
3. The invention defined by claim 2, including a housing having a
recess therein for reception of the container, said recess being
open at one end, said recess having a tapped portion at the open
end, said cap having an externally threaded body threadably
disposed in said tapped portion of the recess, there being an
enlarged head at the outer end of said body.
4. Injector filling apparatus comprising:
A. an injector needle means;
B. a cylindrical container for a fluid sample, said container being
closed at one end and open at the other end;
C. a pierceable seal for covering the open end of the
container;
D. pressurizing means for putting a fluid sample in the container
under pressure for charging said injector needle means with at
least a portion of the sample, said pressurizing means comprising a
cylindrical container plunger operably movable longitudinally in
said container, said plunger having a bore extending longitudinally
therethrough for reception of a filling end of the injector needle
means insertable through the seal and received into the bore
through the plunger and engageable with a part of said container
plunger whereby said plunger may be moved longitudinally toward the
closed end of said container to create injector filling pressure on
sample fluid in the container below the plunger.
5. Injector filling apparatus comprising:
A. a cylindrical container for a fluid sample, said container being
closed at one end and open at the other end;
B. a pierceable seal for covering the open end of the
container;
C. a container plunger positioned within said container for putting
a fluid sample in the container under pressure for charging an
injector with at least a portion of the sample, said plunger having
an axial bore with its upper end flaring inwardly to receive the
injector therein, said plunger further having an external annular
groove therein;
D. a housing having a recess therein for the container, said recess
having an open end with an enlarged tapped portion at said open
end;
E. a cap having an externally threaded body threadedly received in
said tapped portion of the housing recess, said body having a bore
extending from the inner end, the seal for the open end of the
container being disposed in the bore in said body, and an enlarged
head at the outer end of said body, said head having an outer end
wall with an outwardly flaring opening therethrough aligned with
the axial bore through the container plunger.
Description
BACKGROUND OF THE INVENTION
1. Field of the Invention
This invention relates generally to the art of chromatography and
relates more particularly to apparatus or means for filling
injectors or syringes used for injecting samples in chromatographs
and the like.
2. Description of the Prior Art
Heretofore syringes used in chromatography and the like have been
filled by vacuum created by retracting the plungers of such
syringes.
When filling a syringe by retracting the plunger to create a
vacuum, only the pressure difference between atmospheric pressure
and the lower pressure within the syringe created by retracting the
plunger is available to force such fluid into the syringe. Such
differential of pressure is not always sufficient to charge the
syringe. For example, should it be desired to charge a syringe with
a viscous sample it is practically impossible to draw such viscous
sample into the syringe by the vacuum method. However, by applying
large pressures to the liquid relative to the syringe space,
viscous samples may be forced readily into the syringe.
Another problem often occurs when samples are run and there is not
enough time to collect and run them all in one day. With the
present invention when samples cannot be run one day, they may be
kept under seal without evaporation and run at a later time.
BRIEF SUMMARY OF THE INVENTION
The present invention comprises a vial for a fluid sample to be
tested. The upper end of the vial is closed by a septum, diaphragm
or seal which when a needle is pushed through it will seal itself
when the needle is withdrawn.
When an injection device or syringe is to be charged, the needle
thereof is inserted into the vial, through the septum, into the
fluid sample, and pressure applied to the sample for forced
charging of the injector or syringe with the sample.
OBJECTS AND ADVANTAGES OF THE INVENTION
It is therefore an object of the invention to provide means or
apparatus for charging by relatively high-pressure injectors or
syringes with fluid samples to be tested.
It is another object of the invention to provide apparatus of this
character having containers, such as vials, for the samples to be
tested wherein such samples may be kept without impairment or
evaporation.
Still another object of the invention is to provide means which
will prevent fractionation of samples during storage where such
samples have parts or elements of different volatility.
A further object of the invention is to provide apparatus of this
character wherein the exterior surface of the needle is wiped off
when the syringe has been charged and the needle is withdrawn from
the vial or container.
A still further object of the invention is to provide apparatus of
this character wherein the vial is provided with a plunger for
providing the filling pressure and with certain types of needles
said needles are flushed, the flushing fluid being isolated above
the plunger.
The characteristics and advantages of the invention are further
sufficiently referred to in connection with the following detailed
description of the accompanying drawings which represent certain
embodiments. After considering these examples, skilled persons will
understand that many variations may be made without departing from
the principles disclosed and I contemplate the employment of any
structures, arrangements or modes of operation that are properly
within the scope of the appended claims.
Referring to the drawings, which are for illustrative purposes
only:
FIG. 1 is a longitudinal sectional view of apparatus embodying the
present invention;
FIG. 2 is a reduced longitudinal sectional view of the same,
showing a syringe needle, partly in section, inserted into the
plunger of the apparatus and before pressure is applied to the
plunger by means of the needle;
FIG. 3 is a view similar to FIG. 2 but showing the plunger after it
has been forced downwardly in the vial, flushing fluid being
isolated above the plunger; and
FIG. 4 is an enlarged longitudinal section of the injector or
injection device shown in FIGS. 2 and 3.
Referring more particularly to FIG. 1, there is shown a housing,
indicated generally at 10, having a recess therein, comprising a
bore 12 with an enlarged tapped, upper end portion 14. A sample
container which is termed herein a vial is indicated at 16 and is
of any suitable material, such as glass for example. The vial is
cylindrical and is removably disposed in the bore 12, the lower end
of the vial is closed by a bottom wall 18, the upper end of said
vial being open. While only one vial is shown herein it is to be
understood that the housing may have provision for a plurality of
vials or separate housings may be used for the vials.
Within the vial is a cylindrical plunger or piston, indicated
generally at 20, of any suitable material, such as stainless steel
for example, that is unaffected by the sample. The plunger is of
somewhat smaller outside diameter than the inside diameter of the
vial and said plunger has an external annular groove 22 therein for
reception of an O-ring 24 of suitable material such as neoprene or
Teflon for example, the O-ring providing a sliding seal between the
plunger and the cylindrical wall of the vial.
There is a longitudinally extending axial bore 26 through the
plunger 20 which includes a flaring upper end portion 28. Otherwise
stated, the upper end portion 28 tapers downwardly and inwardly
from the upper end of the plunger.
The bottom 18 of the vial 16 rests on the bottom 30 of the bore 12
and the upper end of said vial is closed by a septum, indicated
generally at 32 which is disposed in the upper end of a bore 34 of
a cap, indicated generally at 36. Cap 36 has an externally threaded
body 38 screwed into the threaded portion 14 of the recess in the
housing 10. At the upper end of the body 38 of the cap 36 there is
an enlarged head 40 having an outer end wall 42 with an axial
opening 44 therethrough which tapers inwardly and downwardly from
the top surface of said outer end wall 42.
Septum 32 may be of any suitable character and material. As shown,
said septum has three layers 32a, 32b and 32c of rubber and a layer
33 of "Teflon," the latter being at the bottom and exposed to the
interior of the vial. An example of this septum is the septum
disclosed in the McGuckin application for a SEALING ELEMENT, filed
Apr. 25, 1966, Ser. No. 544,950, now U.S. Pat. No. 3,463,339 issued
Aug. 26, 1969. "Teflon" is the trademark of the Du Pont Company for
their fluorocarbon resins. The advantage of having the "Teflon"
facing the contents of the vial is that the "Teflon" is chemically
inert and thus the septum presents a chemically inert surface to
the contents of the vial and thereby keeps said contents free from
contamination.
The above described arrangement, shown in FIGS. 1 to 3, is used to
charge an injector or injection device, indicated generally at
48.
The injector 48 is shown enlarged in FIG. 4, and comprises a
tubular barrel 50 that is cylindrical and is of suitable material
such as stainless steel for example. A tip, indicated generally at
52, is attached to the forward end of the barrel, said tip having a
forward end portion 54 which tapers toward the front end and a rear
end portion 56 that is cylindrical and is disposed in a forward end
portion of the barrel and is secured therein by a suitable
well-known adhesive such as, for example, an epoxy cement. The
portion 56 is of reduced diameter relative to the rear end of the
tapered portion 54 thereby providing a shoulder 58 against which
the forward end of the barrel abuts. A passage 60 extends
longitudinally throughout the length of the tip.
Slidable within the barrel is a plunger head 62 carried at the
forward end of a plunger rod 64 which is longitudinally slidable
within the barrel. The plunger head 62 may be of any suitable
material such as neoprene, "Teflon" or other plastic. The plunger
rod is of stainless steel or other suitable material and is
provided with a suitable head, not shown, to facilitate actuation
thereof.
Adjacent the inner end of the rear part 56 of the tip the barrel
has a side opening or port 66 that is adapted to be closed by the
plunger head 62 when at its forward limit of movement whereat it is
in abutment with the rear end 68 of said rear part 56. When the
plunger head 62 is retracted the port 66 is open.
When it is desired to charge the injector 48 with a fluid sample 63
which is disposed in the vial below the plunger 20 the tip 52 of
the injector is forced through the septum 32, it being understood
that the injector plunger 62 is in a retracted position so that the
side port 66 is uncovered and open. The tip is inserted further
through the septum and into the flared portion 28 of the bore 26 in
the vial plunger or piston 20, the tip entering into said bore 26 a
sufficient distance to sealingly engage the bore, as for example at
the junction of the lower portion of said bore 26 and the flared
portion 28 thereof. The parts of the apparatus are then positioned
as shown in FIG. 2.
Further forcing the injector downwardly moves the vial plunger 20
downwardly. The sample below the vial plunger 20 is thereby forced
upwardly into the passage 60 of the injector tip 52, into the
barrel and out through the port 66 into the space in the vial above
the vial plunger 20.
Thus the injector is flushed to remove therefrom any sample fluid
that may have been retained in the injector from a previous sample.
In this way the needle becomes essentially free from former samples
and cross-contamination of different samples is eliminated.
When the injector has been flushed and filled with only the fresh
sample to be tested the injector plunger 62 is moved into
engagement with the inner end 68 of the tip portion 56 thereby
closing the port 66. The needle or tip 52 is then removed from the
vial and as it is removed, sample fluid that may be present on the
exterior thereof is wiped therefrom by the septum.
It is to be understood that a septum may be used that does not have
the "Teflon" layer 32d but when some chemicals are to be tested and
placed in a vial it is necessary to use a septum with such a layer
or a comparable layer.
Should it be desired to keep samples for a period of time, say
overnight or the like, the septum prevents the sample or the more
volatile fractions thereof from evaporating.
* * * * *