(SuperStar[])AUC tot   ratio=((Total   AUC   of   parent   after   IV   administrationof   Prodrug)/(Total   AUC   of   parent   after   IV   administrationof   parent   (historic   data)))(^( ** ))AUC tot   ratio=((Total   AUC   of   parent   after   PO   administrationof   Prodrug)/(Total   AUC   of   parent   after   PO   administrationof   parent   (historic   data)))